Stage IVA Uterine Corpus Cancer AJCC v8

Stage IVA includes: T4, Any N, M0. T4: Uterine corpus carcinoma or carcinosarcoma with tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


Slow Growing Mass

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Arbovirus hemorrhagic fever

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A group of viral illnesses that are vectored by arthropods, and that are characterized by increased susceptibility to bleeding diatheses.


Grade 3 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ovulatory Pain

Painful sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.


Grade 3 Ankle Fracture, CTCAE

Limiting self care ADL; elective operative intervention indicated requiring hospitalization


Grade 2 Generalized Edema, CTCAE

Interfering with instrumental ADLs; oral therapy initiated


Grade 5 Uterine Infection, CTCAE

Death


Urinary Tract Infection, CTCAE

A disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra.


Grade 4 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Locally Advanced Cutaneous Melanoma

Cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Dysphagia, CTCAE

Death


Malignant Intracranial Neoplasm

A malignant neoplasm involving the intracranial space.


Cutaneous Acute Graft versus Host Disease

Skin manifestations of acute graft versus host disease, which typically presents as an erythematous maculopapular rash involving the face, ears, palms, and soles that may spread to the trunk and evolve to erythroderma.


Chronic Active EBV Infection of T-and NK-Cell Type, Systemic Form

An on-going Epstein-Barr virus (EBV) infection characterized by repeated infectious mononucleosis-like symptoms, a very high titer of anti-EBV antibodies, and high levels of Epstein-Barr virus nucleic acids. Patients with CAEBV often develop progressive cellular and humoral immunodeficiency with pancytopenia and hypogammaglobulinemia.


Clinical Stage IA Cutaneous Melanoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Urinary Tract NOS Intra-Operative Injury, CTCAE


Breast Neurofibroma

A neurofibroma that arises from the breast.


Grade 2 Vasculitis, CTCAE

Moderate symptoms, medical intervention indicated


Gastric Fistula, CTCAE

A disorder characterized by an abnormal communication between the stomach and another organ or anatomic site.


Diarrhea, CTCAE

A disorder characterized by an increase in frequency and/or loose or watery bowel movements.


Advanced Cutaneous Melanoma of the Extremity

Cutaneous melanoma of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Superior Vena Cava Intra-Operative Injury, CTCAE


Grade 4 Hydrocephalus, CTCAE

Life-threatening consequences; urgent intervention indicated


Radiation-induced fibrous mediastinitis

Fibrous mediastinitis arising due to radiation therapy.


Grade 1 Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


Grade 3 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Delirium, CTCAE

Moderate and acute confusional state; limiting instrumental ADL


Recurrent Extrapulmonary Small Cell Neuroendocrine Carcinoma

The reemergence of extrapulmonary small cell neuroendocrine carcinoma after a period of remission.


Sessile Serrated Adenoma/Polyp

Polyps that arises from the large intestine and the appendix. They are characterized by the presence of serrated glands and the absence of generalized dysplasia.


Intrapartum Uterine Rupture

An acute symptomatic tearing of the uterine wall after the onset of labor.


Childhood Acute Myeloid Leukemia with Minimal Differentiation

An acute myeloid leukemia with minimal differentiation occurring in children.


Perforation of organ

A rupture in an organ(s) due to traumatic or pathologic processes.


Stage III Adult Diffuse Small Cleaved Cell Lymphoma

Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Childhood Central Nervous System Neoplasm

A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in children.  Representative examples include posterior fossa astrocytoma, optic pathway glioma, medulloblastoma, ependymoma, and craniopharyngioma.


Grade 3 Psychosis, CTCAE

Severe psychotic symptoms (e.g., paranoid, extreme disorganization); hospitalization not indicated; new onset


Grade 3 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Regimen-Limiting Toxicity

A side effect of a drug or other treatment that is serious enough to necessitate a dose modification.


Grade 4 Cranial Nerve XII Neuropathy, CTCAE


Grade 1 Blood and Lymphatic System Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 3 Malaise, CTCAE

Uneasiness or lack of well being limiting self-care ADL


Musculoskeletal toxicity

A toxicity that impairs or damages the musculoskeletal system.


Grade 3 Irritability, CTCAE

Severe abnormal or excessive response; limiting self care ADL; inconsolable; medical or psychiatric intervention indicated


Grade 3 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Injury of diaphragm with open wound into cavity

Trauma to  the diaphragm associated with a break in the tissue that extends into the thoracic cavity.


Stage IIB Osteosarcoma AJCC v7

Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 4 Postoperative Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Head Mass

An abnormal growth located on the head.


Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Lip Or Perioral Area Intra-Operative Injury, CTCAE


Defective T-Cell Receptor Signaling

An indication that T-cell receptor (TCR)-dependent signaling pathways in a immunologic sample are compromised. TCR signaling defects lead to impaired development of T-lymphocytes and are usually caused by deletion or loss of function mutations affecting one or more proteins involved in TCR-dependent signaling pathways, including the subunits of the TCR complex.


Pancreatic Cancer by AJCC v8 Stage

A term that refers to the staging of exocrine pancreatic cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to pancreatic ductal adenocarcinoma, acinar cell carcinoma, intraductal papillary mucinous neoplasm with associated invasive carcinoma, intraductal tubulopapillary neoplasm with associated invasive carcinoma, colloid carcinoma, mucinous cystic neoplasm with associated invasive carcinoma, solid pseudopapillary neoplasm, large cell neuroendocrine carcinoma, small cell neuroendocrine carcinoma, and pancreatoblastoma. Well-differentiated neuroendocrine tumors are not staged using this staging system. (from AJCC 8th Ed.)


Primary Bone Osteosarcoma

A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It usually involves the long bones and predominantly affects adolescents and young adults. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs.


Grade 2 Brachial Plexus Intra-Operative Injury, CTCAE


Grade 3 Neonatal Fever, AE

An adverse event in a newborn characterized by fever, major change in baseline age-appropriate behavior and without resolution to symptomatic treatment.


Grade 4 Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


Chlamydia psittaci infection

A bacterial infection caused by Chlamydophila psittaci. Humans are infected by handling sick birds. The Chlamydiae cause respiratory infection manifests with fever, malaise, cough, dyspnea, sore throat, photophobia and headaches.


Decreased Time To Peak Drug Blood Concentration

Decreased time following drug administration at which the peak drug blood concentration occurs.


Grade 2 Hematosalpinx, CTCAE

Moderate bleeding; medical intervention indicated


Grade 2 Renal and Urinary Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Clinical Test Result

The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition.


Grade 4 Bronchus Obstruction and Stenosis, CTCAE


Stage IVB Cervical Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


Grade 4 Other Sexual Reproductive Function, CTCAE


Neonatal Constipation, AE

An adverse event in a newborn characterized by irregular and infrequent or difficult evacuation of the bowels.


Grade 2 Small Bowel Perforation NOS, CTCAE


Recurrent Adult Diffuse Small Cleaved Cell Lymphoma

The reemergence of adult diffuse small cleaved cell lymphoma after a period of remission.


Phantom Pain Associated with Missing Limb, CTCAE


Adverse Event Attributed to Other Cause

An indication that an adverse event is causally related to an entity that is a not a disease- or research-related process nor a commercial product or investigational new drug (IND).


Advanced Neuroendocrine Tumor

A neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Round Cell Sarcoma with EWSR1-NFATC2 Gene Fusion

A group of rare round and spindle cell sarcomas characterized by the presence of EWSR1-NFATC2 gene fusion.


Grade 3 Larynx Intra-Operative Injury, CTCAE


Grade 2 Adrenal Insufficiency, CTCAE

Moderate symptoms; medical intervention indicated


Refractory Gastric Carcinoma

Gastric carcinoma that does not respond to treatment.


Grade 2 Depressed Level of Consciousness, CTCAE

Sedation; slow response to stimuli; limiting instrumental ADL


Grade 4 Aortic Injury, CTCAE

Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


IOL dislocation

Displacement of the intraocular lens from the visual axis.


Grade 5 Gallbladder Fistula, CTCAE

Death


Stage IIA1 Cervical Cancer FIGO 2018

Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, less than 4 cm in greatest dimension. (FIGO 2018)


Refractory Giant Cell Glioblastoma

Giant cell glioblastoma that is resistant to treatment.


Grade 1 Hyperkalemia, CTCAE

>ULN-5.5 mmol/L


Genitourinary System Carcinoma

A carcinoma arising from the genitourinary system. Representative examples include kidney carcinoma, bladder carcinoma, prostate carcinoma, endometrial carcinoma, cervical carcinoma, and ovarian carcinoma.


Toothache, CTCAE

A disorder characterized by a sensation of marked discomfort in the tooth.


Grade 5 Ovarian Rupture, CTCAE

Death


Grade 5 Upper Gastrointestinal Hemorrhage, CTCAE

Death


Reproductive System and Breast Disorders - Other, Specify, CTCAE


Grade 1 Injection Site Reaction or Extravasation Changes, CTCAE


Anti-D Hemolytic Disease of the Newborn

A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of antibodies from a mother to the child via the placenta against the D antigen, the most common Rhesus factor.


Non-Neoplastic Thoracic Disorder

A non-neoplastic disorder that affects the thorax and/or the organs of the thoracic cavity.  Representative examples include pleural infection, mediastinitis, pneumonia, and chronic obstructive pulmonary disease.


Splenic Rupture Related to Birth

Disruption of the spleen incurred during delivery.


Regional Urothelial Carcinoma of the Renal Pelvis and Ureter

A transitional cell carcinoma of the renal pelvis or ureter that has not spread to other regions.


Sarcoma of the Extremity

A sarcoma that arises from the soft tissues or bones of the upper or lower extremity.


Grade 2 Visceral Arterial Ischemia, CTCAE

Brief (<24 hrs) episode of ischemia managed medically and without permanent deficit


Fetal Hypoxia

Hypoxia in utero, caused by conditions such as inadequate placental function (often abruptio placentae), preeclamptic toxicity, prolapse of the umbilical cord, or complications from anesthetic administration.


Eye Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 3 Olfactory Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Recurrent Urinary System Carcinoma

Reemergence of a urinary system carcinoma after a period of remission.


Severe Mosquito Bite Allergy

An EBV-positive NK-cell lymphoproliferative disorder characterized by high fever and intense local skin symptoms, including erythema, bullae, ulcers, skin necrosis, and deep scarring following mosquito bites. Patients have NK-cell lymphocytosis in the peripheral blood and an increased risk of developing hemophagocytic syndrome and progressing into overt NK/T-cell lymphoma or aggressive NK-cell leukemia in the longstanding clinical course. (WHO 2017)


Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Uterine Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the uterus.


Grade 2 Ileal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Classical Hodgkin lymphoma type posttransplant lymphoproliferative disorder

An Epstein-Barr positive lymphoproliferation fulfilling the criteria for classic Hodgkin lymphoma and arising as a result of post-transplant immunosuppression therapy.  It is most often seen in renal transplant patients.


Stage I Gallbladder Cancer AJCC v7

Stage I includes: T1, N0, M0. T1: Tumor invades lamina propria or muscular layer.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Metastatic Digestive System Carcinoma

A carcinoma that arises from the gastrointestinal system and has metastasized to other anatomic sites.


Unresectable Meningioma

A meningioma that is not amenable to surgical resection.


Stage IV Adult Diffuse Large Cell Lymphoma

Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Personality Change, CTCAE

A disorder characterized by a conspicuous change in a person's behavior and thinking.


Spinal Cord Hamartoma

A hamartoma that occurs in the spinal cord.


Grade 4 Other Renal or Genitourinary, CTCAE


Grade 3 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Lymphoma, AIDS-Related

An aggressive lymphoma that develops in HIV-positive patients.  There is a significant increase in the incidence of lymphomas associated with the AIDS epidemic.  These lymphomas are usually extranodal, most often express a B-cell phenotype and morphologically are classified as Burkitt, diffuse large B-cell, and Hodgkin lymphomas.  The prognosis is closely related to the severity of immunodeficiency.


Stage IV Appendix Neuroendocrine Tumor AJCC v7

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Grade 1 Other Blood and Bone Marrow, CTCAE


Rectal Ulcer, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the rectum.


Cervical Neuroendocrine Tumor

A well-differentiated neuroendocrine neoplasm that arises from the cervix. It may be classified as G1 (low grade) or G2 (intermediate grade) neuroendocrine tumor.


Gastric Antrum Carcinoma In Situ AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Primary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtype

A rare, mature T-Cell lymphoma arising from the skin.


Grade 3 Non-Malignant Pericardial Effusion, CTCAE


Locally Advanced Urothelial Carcinoma

A urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


High Grade Urothelial Carcinoma

Urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


Grade 3 Edema Limbs, CTCAE

>30% inter-limb discrepancy in volume; gross deviation from normal anatomic contour; limiting self care ADL


Grade 2 Stomach Intra-Operative Injury, CTCAE


Grade 2 Small Bowel NOS Intra-Operative Injury, CTCAE


Recurrent Astrocytoma, IDH-Mutant

The reemergence of IDH-mutant astrocytoma after a period of remission.


Vaginal Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures).


Congenital Vena Cava Abnormality

An abnormality of the superior or inferior vena cava that is present at birth. Representative examples include persistent left superior vena cava, absence of infrarenal inferior vena cava, or absence of the entire inferior vena cava.


Grade 3 Vestibular Disorder, CTCAE

Severe symptoms; limiting self care ADL


Grade 4 Cranial Nerve III Intra-Operative Injury, CTCAE


Grade 2 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Serum CEA Level Elevated

The amount of carcinoembryonic antigen present in a serum sample is elevated.


Grade 5 Pulmonary Valve Disease, CTCAE

Death


Post-Treatment Lyme Disease Syndrome

A constellation of symptoms lasting months to years reported by some Lyme disease patients who had undergone previous antibiotic therapy.


Childhood Langerhans Cell Histiocytosis with Risk Organ Involvement

Langerhans cell histiocytosis that occurs during childhood and involves the bone marrow, spleen, liver, or lung.


Grade 1 Rectal Fistula, CTCAE

Asymptomatic


Grade 1 Body Odor, CTCAE

Mild odor; physician intervention not indicated; self care interventions


Prostate Non-Neoplastic Disorder

A non-neoplastic disorder that affects the prostate gland.  Representative examples include acute and chronic prostatitis.


Grade 5 Cranial Nerve VII Neuropathy, CTCAE


Grade 5 Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Adverse Event Associated with the Endocrine System


Grade 4 Nervous System Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Intraoperative Reproductive Tract Injury, CTCAE

Death


Grade 2 Lung Intra-Operative Injury, CTCAE


Stage IB Pancreatic Cancer AJCC v8

Stage IB includes: T2, N0, M0. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metanephric stromal tumor

A rare benign renal neoplasm composed of moderately cellular spindle cells. It occurs mostly in infancy and childhood.


Grade 5 Rectum Stricture or Stenosis, CTCAE


Extraocular Muscle Paresis, CTCAE

A disorder characterized by incomplete paralysis of an extraocular muscle.


Grade 1 Gastrointestinal Fistula, CTCAE

Asymptomatic


Device Related Infection, CTCAE

A disorder characterized by an infectious process involving the use of a medical device.


Ipsilateral Nodule

A metastatic tumor nodule located in the same side of the organ in which the primary tumor occurred.


Grade 5 Nephrotic Syndrome, CTCAE

Death


Lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 3 Hydrocephalus, CTCAE

Severe symptoms or neurological deficit; intervention indicated


Grade 2 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Joint Infection, CTCAE

A disorder characterized by an infectious process involving a joint.


Blood Cardiac Troponin I Increased

A laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen.


Grade 3 Trachea Intra-Operative Injury, CTCAE


Grade 2 Bronchus Obstruction and Stenosis, CTCAE


Miscellaneous Neoplasm

A benign or malignant neoplasm which is not further characterized.


Prolapse of Intestinal Stoma, CTCAE

A finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface.


Grade 2 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


Esophageal Adenocarcinoma by AJCC v8 Pathologic Stage

A term that refers to the pathologic staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Urinary Frequency, CTCAE

A disorder characterized by urination at short intervals.


Grade 3 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

Severe symptoms; limiting self care ADL; hospitalization


Scrotal hernia

The protrusion of abdominal cavity contents into the scrotal sac.


Integumentary System Signs and Symptoms

Patient complaints (symptoms), physical and/or laboratory findings related to the skin or integument.


Stage I Cervical Cancer AJCC v6 and v7

Stage I includes: I (T1, N0, M0); IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0); IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1: Cervical carcinoma confined to uterus (extension to corpus should be disregarded). T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread.  T1a2: Measured stromal invasion more than 3.0mm and not more than 5.0 mm with a horizontal spread 7.0mm or less. T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 1 Cranial Nerve XI Intra-Operative Injury, CTCAE


COVID-19-Associated Encephalitis

Encephalitis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Recurrent Malignant Nongerminomatous Germ Cell Tumor

The reemergence of a malignant nongerminomatous germ cell tumor after a period of remission.


Grade 3 Rectal Pain, CTCAE

Severe pain; limiting self care ADL


Refractory Malignant Male Reproductive System Neoplasm

Malignant male reproductive system neoplasm that is resistant to treatment.


Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Extraocular Muscle Paresis, CTCAE

Bilateral paresis requiring head turning to see beyond central 60 degrees or double vision in central gaze


Grade 1 Vasculitis, CTCAE

Asymptomatic, intervention not indicated


Enterocolitis, CTCAE

A disorder characterized by inflammation of the small and large intestines.


Grade 2 Neonatal Pulmonary Hemorrhage, AE

An adverse event in a newborn characterized by hemorrhagic secretion in an endotracheal (ET) tube; without relevant increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation; requiring minor changes in care (e.g. increase in positive end-expiration pressure (PEEP)).


Ampulla of Vater Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The mitotic count is 2-20 per 10 HPF.


Advanced Lymphoma

Lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 5 Non-Infectious Wound Complication, CTCAE


Stage IIC Appendix Carcinoma AJCC v7

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades other organs or structures.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 4 Otitis Media, CTCAE

Life-threatening consequences; urgent intervention indicated


Chest Pain Along Left Anterior Axillary Line

The location of the chest pain is along the anterior axillary line on the left side.


Cervical Cancer by AJCC v9 Stage

A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 9th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to sarcomas, lymphomas, and melanomas. Sarcomas are staged according to the corpus uteri classification for sarcomas. Lymphomas are staged according to Hodgkin and non-Hodgkin lymphoma classification. Melanomas are not staged. (from AJCC 9th Ed.)


Grade 2 Hiccups, CTCAE

Moderate symptoms; medical intervention indicated; limiting instrumental ADL


Blood and Lymphatic System Disorders, CTCAE


Recurring Adverse Event

An adverse event that occurs and resolves during a cycle or course of medical intervention and then reoccurs in a later cycle or course.


Digestive System Neuroendocrine Tumor by AJCC v7 Stage

A term that refers to the staging of a digestive system neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


Grade 1 Eyelid Function Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Methemoglobinemia, CTCAE

A disorder characterized by laboratory test results that indicate increased methemoglobin in the blood.


Grade 2 Nervous System Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 2 Spinal Cord Intra-Operative Injury, CTCAE


Stage IIA1 Cervical Cancer AJCC v8

Stage IIA1 includes: T2a1, Any N, M0. T2a1: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Refractory Neuroendocrine Carcinoma

Neuroendocrine carcinoma that does not respond to treatment.


Cutaneous Melanoma by AJCC v8 Stage

A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system. This staging system does not apply to melanoma of the conjunctiva, melanoma of the uvea, mucosal melanoma arising in the head and neck, and mucosal melanoma of the urethra, vagina, rectum, and anus. (from AJCC 8th Ed.)


Pelvis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Grade 2 Small Intestinal Perforation, CTCAE

Invasive intervention not indicated


Dermal nerve sheath myxoma

A usually painless, slow growing benign tumor that most often arises from the extremities. It is characterized by the presence of abundant myxoid matrix and small epithelioid neoplastic Schwann cells.


Congenital Amegakaryocytosis

A rare disorder of infancy characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Grade 2 Thyroid Intra-Operative Injury, CTCAE


Grade 2 Stoma GI Stricture or Stenosis, CTCAE


Grade 1 Duodenal Fistula, CTCAE

Asymptomatic


Grade 1 Cranial Nerve VIII Neuropathy, CTCAE


Ventricular Fibrillation, CTCAE 5.0

A disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles.


Grade 5 Psychosis Including Hallucinations and Delusions, CTCAE


Cannabis dependence, episodic

Physical and psychological dependence on the drug cannabis, which is associated with a pattern of episodic use.


Closed dislocation of hip

A closed dislocation of the hip.


Grade 5 Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Joint Intra-Operative Injury, CTCAE


Upper Extremity Vein Intra-Operative Injury, CTCAE


Metastatic Pancreatic Neuroendocrine Neoplasm

A pancreatic neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


Grade 4 Hypocalcemia, CTCAE

Corrected serum calcium of <6.0 mg/dL; <1.5 mmol/L; Ionized calcium <0.8 mmol/L; life-threatening consequences


Grade 3 Cranial Nerve V Neuropathy, CTCAE


Grade 3 Dyspnea, CTCAE

Shortness of breath at rest; limiting self care ADL


Peripheral Ischemia, CTCAE

A disorder characterized by impaired circulation to an extremity.


Grade 3 Chronic Kidney Disease, CTCAE

eGFR or CrCl 29-15 ml/min/1.73 m2


Non-Neoplastic Hematologic and Lymphocytic Disorder

A disorder that arises from the bone marrow or lymphoid system and is characterized by the absence of a clonal cellular component. It rarely progresses to a malignant neoplasm.


Grade 3 Hypoparathyroidism, CTCAE

Severe symptoms; medical intervention or hospitalization indicated


Grade 5 Treatment Related Secondary Malignancy, CTCAE

Death


Stage II Urethral Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Supraventricular Arrhythmia NOS, CTCAE


Mesonephric Hyperplasia

A hyperplasia of the mesonephric cells.


Stage IB Ampulla of Vater Cancer AJCC v7

Stage IB includes: T2, N0, M0. T2: Tumor invades the duodenal wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Corrosive injury

Destruction of tissue by a chemical substance.


Grade 4 Neonatal Bradyarrhythmia, AE

A bradyarrhythmia adverse event in a newborn characterized by life-threatening consequences (e.g. shock); requiring urgent major care changes.


Grade 4 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Contact lens overwear syndrome (disorder)

Ocular pain which may be very intense, accompanied by corneal epithelium damage, conjunctival injection, lacrimation, blepharospasm, photophobia and hazy vision following corneal edema caused by overwear of contact lenses, principally the PMMA type.


neuroendocrine carcinoma of anal canal

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Grade 3 Restrictive Cardiomyopathy, CTCAE

Symptomatic heart failure or other cardiac symptoms, responsive to intervention; new onset of symptoms


Grade 2 Bullous Dermatitis, CTCAE

Blisters covering 10-30% BSA; painful blisters; limiting instrumental ADL


Lugano Classification Limited Stage Adult Hodgkin Lymphoma AJCC v8

Limited stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Burning Chest Pain

The sensation of chest pain described as an intense discomfort, similar to that experience as a result of a thermal burn, distinct from sharp, stabbing or aching, often related to nerves; sometimes used to describe gastric or esophageal pain.


Unresectable Adenoid Cystic Carcinoma

Adenoid cystic carcinoma that is not amenable to surgical resection.


Intraoperative Head and Neck Injury

Damage to head and neck during a surgical procedure.


AIDS-Related Diffuse Small Cleaved Cell Lymphoma

A non-Hodgkin lymphoma occurring in HIV-positive patients.  It is composed of small cleaved lymphocytes.


Grade 3 Hypertriglyceridemia, CTCAE

>500 mg/dL-1000 mg/dL; >5.7 mmol/L-11.4 mmol/L


Bile Duct Mucinous Cystic Neoplasm, Low Grade

A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of mild atypia.


Childhood Gliosarcoma

A gliosarcoma that occurs during childhood.


Grade 1 Radiculitis, CTCAE

Mild symptoms


Grade 5 Hepatic Hemorrhage, CTCAE

Death


Undifferentiated Carcinoma of Unknown Primary

An undifferentiated carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified.


Grade 4 Wheezing, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


P450 Oxidoreductase Deficiency

Decreased or absent activity of P450 oxidoreductase due to mutation(s) in the POR gene.


Parapsoriasis lichenoides

A rare condition that stimulated chronic radiodermatitis.  It is considered a variant of mycosis fungoides.


acute undifferentiated leukemia in relapse

The reemergence of acute undifferentiated leukemia after a period of remission.


Sweat Gland Tubular Carcinoma

An aggressive adenocarcinoma that arises from the sweat glands. It usually presents as a firm, erythematous nodular lesion in the axilla. Morphologically, it is characterized by the presence of tubular structures and apocrine differentiation.


Grade 3 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage III Vulvar Cancer AJCC v8

Stage III includes: T1-T2, N1-N2c, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. N2a: Three or more lymph node metastases each less than 5 mm. It includes micrometastasis, N2mi. N2b: Two or more lymph node metastases equal to 5 mm. N2c: Lymph node(s) metastasis with extranodal extension. M0: No distant metastasis. (AJCC 8th Ed.)


Reaction to Medicinal Component of Device

Any local or systemic adverse reaction to the medicinal component of a combination product.


Parathyroid chief-cell hyperplasia

A hyperplasia of the chief cells of the parathyroid gland.


Grade 5 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Lower Thigh Pain

A painful sensation in the distal thigh area.


Grade 3 Esophageal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 2 Vaginal Discharge, CTCAE

Moderate to heavy vaginal discharge; use of perineal pad or tampon indicated


Balloon cell nevus

An uncommon variant of melanocytic nevus. It presents as a small pigmented skin lesion. It is characterized by the presence of large melanocytes with clear, foamy or finely vacuolated cytoplasm. It may recur if it is not completely excised.


Endocrine Therapy Toxicity

Indicates that a toxicity adverse effect has been experienced during endocrine drug treatment.


Microcyst

A tiny cyst that is usually identified by microscopic examination in a tissue specimen.


Sacral Myelocele

Herniation of spinal cord tissue and meninges through a defect in the sacral region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Grade 2 Neonatal Sinus Bradycardia, AE

An adverse event in a newborn characterized by persistent sinus bradycardia; no change in age-appropriate behavior; requiring minor care changes (e.g. concomitant medication adapted, intermittent increase of fraction of inspired oxygen (FiO2)).


Gallbladder Perforation, CTCAE 5.0

A disorder characterized by a rupture in the gallbladder wall.


Grade 4 Pancreatic Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Hepatic Infection, CTCAE

Death


Grade 3 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Anorectal Infection, CTCAE

Death


Metastatic Neoplasm to the Bladder

The spread of a malignant neoplasm to the urinary bladder wall from an adjacent or distant anatomic site.


Grade 5 Tracheal Hemorrhage, CTCAE

Death


Grade 3 Hypomagnesemia, CTCAE

<0.9-0.7 mg/dL; <0.4-0.3 mmol/L


Long-Term Effects Secondary to Cancer Therapy in Children


Lugano Classification Stage III Adult Lymphoma AJCC v8

Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Prolapse of Urostomy, CTCAE

A finding of displacement of the urostomy.


Enterochromaffin-Like Cell Neuroendocrine Tumor G1

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) arising from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like type granules in the neoplastic cells.


Colonic Fistula, CTCAE

A disorder characterized by an abnormal communication between the large intestine and another organ or anatomic site.


Grade 4 Small Bowel Perforation NOS, CTCAE


Stage IVB Gallbladder Carcinoma

Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1).  N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis. (from AJCC 7th Ed.)


Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


Folliculitis, CTCAE

A disorder characterized by inflammation or infection of the hair follicles.


Chronic Total Occlusion Vessel

A longstanding, complete blockage of a vessel. (ACC)


Grade 2 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Hematoma of rectus sheath

A collection of blood in the rectus sheath due to disruption of the superior or inferior epigastric arteries, which may present following direct trauma to the rectus abdominis muscle or anticoagulation therapy.


Malignant Germinative Follicular Epithelium Neoplasm

A malignant neoplasm that arises from germinative follicular epithelial cells.


Ampulla of Vater Cancer by AJCC v7 Stage

A term that refers to the staging of ampulla of Vater cancer according to the American Joint Committee on Cancer, 7th edition.


Recurrent Childhood Central Nervous System Neoplasm

The reemergence of central nervous system neoplasm in childhood after a period of remission.


Grade 4 Conduction Disorder, CTCAE

Life-threatening consequences


Grade 2 Upper Extremity Artery Intra-Operative Injury, CTCAE


Grade 1 Cranial Nerve VII Neuropathy, CTCAE


Hypothyroidism, CTCAE

A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland.


Grade 3 Stroke, CTCAE

Severe neurologic deficit; limiting self care ADL; hospitalization


Grade 2 Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE


COVID-19-Associated Stroke

Cerebrovascular accident caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Stage 0 Uterine Corpus Cancer

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas.  FIGO no longer includes Stage 0 (Tis). (AJCC 7th ed.)


Grade 4 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pulmonary Edema, CTCAE

Severe dyspnea or dyspnea at rest; oxygen indicated; limiting self care ADL


Metastatic Digestive System Neuroendocrine Tumor G2

Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to another anatomic site.


Grade 4 Laryngeal Obstruction, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Hirsutism, CTCAE

In women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair


Grade 3 Dental and Teeth and Peridontal Pain, CTCAE


Stage IVB Cervical Cancer FIGO 2018

The cervical carcinoma has spread to distant organs. (FIGO 2018)


Grade 1 Brain Intra-Operative Injury, CTCAE


Cervical Papillary Squamous Cell Carcinoma

A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures covered with epithelial cells which show features of cervical intraepithelial neoplasia. The malignant cellular component below the papillary structures is a squamous cell carcinoma.


Intraoperative Hemorrhage

Uncontrolled bleeding during a surgical procedure.


Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during childhood.


Grade 4 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Refractory Primary Amyloidosis

Primary amyloidosis that does not respond to treatment.


Conjunctiva Intra-Operative Injury, CTCAE


Grade 5 Other Dermatology or Skin, CTCAE


Plasma Kallikrein Deficiency

A coagulation disorder characterized by the partial or complete absence of plasma-type kallikrein activity in the blood.


Grade 2 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Nipple Deformity, CTCAE

A disorder characterized by a malformation of the nipple.


Lactation Disorder, CTCAE

A disorder characterized by disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males.


Grade 5 Ventricular Fibrillation, CTCAE

Death


Grade 2 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Childhood Refractory Malignant Solid Neoplasm

A childhood malignant solid neoplasm that does not respond to treatment.


Factor VII Inactivation

Presence of inactivating antibodies to factor VII in the blood.


Intraoperative Urinary System Injury

Damage to any part of the urinary system during a surgical procedure.


Blast Injuries

The result of physical trauma sustained in an explosion.


Grade 3 Conjunctivitis, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Grade 2 Urethral Infection, CTCAE

Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Discoid Rash

A disc-shaped patch(es) of skin inflammation that is red, raised, and scaly; it typically develops on the face, scalp, and neck, and often leaves scars and dyspigmentation as a result of postinflammatory hyperpigmentation.


Grade 4 Perforation Bile Duct, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Facial Muscle Weakness, CTCAE

Moderate symptoms; limiting instrumental ADL


Adult Hodgkin Lymphoma

Hodgkin lymphoma occurring in adults.


Signet Ring Cell/Histiocytoid Carcinoma

A rare aggressive adnexal carcinoma preferentially affecting the eyelid and histopathologically resembling a metastatic lobular carcinoma of the breast and/or some adenocarcinomas arising in the gastrointestinal tract. (WHO 2018)


benign mature teratoma of pancreas

A mature teratoma that arises from the pancreas.


Recurrent Low Grade Adult Non-Hodgkin's Lymphoma


Early Prosthetic Valve Endocarditis

Prosthetic valve endocarditis that occurs days to weeks after surgery.


Advanced Pancreatic Carcinoma

Pancreatic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Meningohydroencephalocele

A congenital neural tube closure defect resulting in protrusion of the brain, the meninges, and the ventricular system through an opening in the skull, usually involving the squamous part of the occipital bone..


Skin squamous cell carcinoma metastatic

Squamous cell carcinoma of the skin which has spread to other anatomic sites.


Confusion, CTCAE 5.0

A disorder characterized by a lack of clear and orderly thought and behavior.


Grade 2 Cough, CTCAE

Moderate symptoms, medical intervention indicated; limiting instrumental ADL


Grade 4 Cerebral Artery Intra-Operative Injury, CTCAE


Refractory Cervical Adenocarcinoma

Cervical adenocarcinoma that is resistant to treatment.


Grade 1 Cerebrospinal Fluid Leakage, CTCAE

Post-craniotomy: asymptomatic; Post-lumbar puncture: transient headache; postural care indicated


Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Chest Pain Along Midclavicular Line

The location of the chest pain is along an imaginary vertical line on the chest originating from the midpoint of a clavicle.


Grade 2 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Poorly Differentiated Prostate Adenocarcinoma

An invasive prostate adenocarcinoma characterized by the presence of poorly differentiated malignant cells.


Grade 3 Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Bronchus Obstruction and Stenosis, CTCAE


Sickle cell-thalassemia disease

Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene.


Unfavorable Hodgkin Lymphoma

A Hodgkin lymphoma with unfavorable prognosis.


Primary Parathyroid Gland Hyperplasia

Parathyroid gland hyperplasia that occurs in the absence of physiological stimuli.


Stage IVB Osteosarcoma AJCC v7

Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 2 Muscle Intra-Operative Injury, CTCAE


Pericardial Adenomatoid Tumor

A very rare benign neoplasm of mesothelial origin that arises from the pericardium.


Infarction of spinal cord

Ischemic necrosis of the spinal cord caused by occlusion of the arteries that supply blood to the spinal cord. Signs and symptoms include intermittent back pain, pain in the legs, paralysis, and incontinence.


Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Prostatic Hemorrhage, CTCAE

Death


Lower Ribs Pain

A sensation of discomfort emanating from the inferiormost (verterbrochondral or vertebral) ribs.


Hereditary Angioedema Types I and II

Autosomal dominant inherited disorders characterized by abnormalities of C1 inhibitor. Patients present with swelling of the skin, subcutaneous tissues, and mucosa sites. In type I hereditary angioedema, the plasma levels of C1 inhibitor are decreased. In type II hereditary angioedema, the C1 inhibitor is dysfunctional and its plasma levels may be normal or elevated.


Grade 2 Portal Hypertension, CTCAE

Decreased portal vein flow


Grade 4 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Uterine Corpus Cancer by AJCC v7 Stage

A term that refers to the staging of uterine corpus cancer (carcinoma or carcinosarcoma) according to the American Joint Committee on Cancer, 7th edition.


Grade 1 Penile Infection, CTCAE

Localized, local intervention indicated


Injury To Carotid Artery, CTCAE

A finding of damage to the carotid artery.


Recurrent Malignant Bone Neoplasm

Reemergence of a malignant bone neoplasm after a period of remission.


Gallbladder Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma

A mucinous cystic neoplasm that arises from the gallbladder and it is associated with an invasive carcinomatous component.


Sporadic Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is not caused by inherited genetic mutations.


Carcinoid tumor of the liver

An extremely rare, well differentiated neuroendocrine neoplasm arising from the liver. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation.


Grade 2 Glucose Intolerance, CTCAE

Symptomatic; dietary modification or oral agent indicated


Voice Alteration

Change in the sound and/or speed of the voice. Causes include laryngeal polyp, laryngitis, laryngeal carcinoma, throat carcinoma, Parkinson's disease, multiple sclerosis, stroke, hypothyroidism, oral surgery, tracheostomy, tracheal injury, and laryngeal injury.


Grade 4 Anal Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Mediastinal Infection, CTCAE

A disorder characterized by an infectious process involving the mediastinum.


Grade 3 Sinusitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 1 Malaise, CTCAE

Uneasiness or lack of well being


TdT Positive Acute Lymphoblastic Leukemia


Anoxia

Absence or reduction of oxygen in body tissue.


Adult Gliosarcoma

A gliosarcoma occurring in adults.


Grade 1 Pancreas Intra-Operative Injury, CTCAE


Stage II Ureter Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Reactogenicity

An expected set of reactions that may occur soon after injection of a vaccine. These expected adverse reactions are a physical manifestation of the inflammatory response to the vaccine.


Mosquito-borne hemorrhagic fever

A group of viral illnesses that are vectored by mosquitoes, and that are characterized by increased susceptibility to bleeding diatheses.


Grade 2 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Intraoperative Breast Injury, CTCAE

Primary repair of injured organ/structure indicated


congenital renal arteriovenous malformation

A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the kidney.


Grade 2 Cerebrospinal Fluid Leakage, CTCAE

Post-craniotomy: moderate symptoms; medical intervention indicated; Post-lumbar puncture: persistent moderate symptoms; blood patch indicated


Grade 5 Neonatal Edema, AE

An edema adverse event in a newborn which results in death.


Craniotubular Hyperostosis

A group of sclerosing bone dysplasias characterized by pronounced sclerosis of the cranial vault and the long bones, resulting in increased cortical bone density. Most cases are caused by mutation(s) in the SOST or LRP5 genes, encoding sclerostin and low-density lipoprotein receptor-related protein 5, respectively. Other genes have been implicated, and some cases have been described, but do not yet have identified genetic mutations.


Hepatic Artery Intra-Operative Injury, CTCAE


Grade 5 Papulopustular Rash, CTCAE

Death


Middle Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


Stage IB Gestational Trophoblastic Tumor AJCC v7

Stage IB includes: T1, M0, Risk factors: high risk.  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


Premature Ventricular Contraction, CTCAE


Grade 1 Vaginal Fistula, CTCAE

Asymptomatic


Major Visceral Artery Intra-Operative Injury, CTCAE


Disseminated carcinoma

Carcinoma that is spread throughout the body.


Insomnia due to organic factors

Insomnia as a result of a physiological cause.


Grade 3 Urinary Frequency or Urgency, CTCAE


Congenital kyphosis

An abnormally increased curvature of the thoracic portion of the spine that is present at the time of birth.


Human Papillomavirus-Related Malignant Neoplasm in AIDS Patient

A malignant neoplasm caused by human papillomavirus in an a patient with a history of AIDS.


Fallopian Tube Intra-Operative Injury, CTCAE


Hypocalcemia, CTCAE

A disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the blood.


Metastatic Malignant Solid Neoplasm

A malignant solid neoplasm that has spread from its original site of growth to another anatomic site.


Grade 3 Scrotal Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 5 Pneumothorax, CTCAE

Death


Tiring Pain

A sensation of discomfort or distress that renders an individual weary and without energy.


Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Reproductive System and Breast Disorders, CTCAE


Complication of labor and delivery, unspecified

The occurrence of a pregnancy complication during childbirth, which includes both labor (the process of childbirth) and delivery (the birth itself).


Fibromyxolipoma

A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue and extensive myxoid change.


Salt-Wasting 21-Hydroxylase Deficiency

A classic form of congenital adrenal hyperplasia characterized by complete absence of 21-hydroxylase activity resulting in deficiency of glucocorticoids and mineralocorticoids accompanied by androgen excess causing virilization in female infants. Mineralocorticoid deficiency results in renal salt-wasting, and if untreated, hyponatremia, hyperkalemia, and shock.


Grade 2 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Appendix Mucinous Cystadenoma

A cystically dilated epithelial neoplasm arising from the appendix.  It is characterized by the presence of a cystic structure that is filled with mucus.


Hodgkin's disease, nodular sclerosis of lymph nodes of multiple sites

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 3 Gastroparesis, CTCAE

Weight loss >=20% from baseline; tube feeding or TPN indicated; elective operative intervention indicated


Metastatic Bladder Small Cell Neuroendocrine Carcinoma

Bladder small cell neuroendocrine carcinoma that has spread to another anatomic site.


Prostate Cancer by Whitmore-Jewett Stage

A term that refers to the staging of prostate carcinoma according to the Whitmore-Jewett staging system.


Grade 3 Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Injury To Inferior Vena Cava, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Chylothorax, CTCAE

A disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity.


Small Bowel Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Clinical Stage II Cutaneous Melanoma AJCC v8

Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 4 Thorax Soft Tissue Necrosis, CTCAE


Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA

Chronic eosinophilic leukemia characterized by the rearrangement of the PDGFRA gene, most often resulting in the formation of FIP1L1-PDGFRA fusion transcripts.


Suicidal Ideation, CTCAE

A disorder characterized by thoughts of taking one's own life.


Grade 5 Social Circumstances - Other, Specify, CTCAE

Death


Angiosarcoma recurrent

The reemergence of angiosarcoma after a period of remission.


Glioblastoma by Gene Expression Profile

Classification of glioblastoma into molecular subtypes as defined by gene expression profiling.


Metastatic Midgut Neuroendocrine Tumor

A midgut neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Grade 1 Chylothorax, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Fluid Discharge

The pouring forth of a fluid.


Grade 3 Uterus Stricture or Stenosis, CTCAE


Stage III Anal Cancer AJCC v8

Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T4, N0, M0); IIIC: (T3, N1, M0); (T4, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. T3: Tumor larger than 5 cm. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


Photophobia, CTCAE 5.0

A disorder characterized by fear and avoidance of light.


Grade 1 Memory Impairment, CTCAE

Mild memory impairment


Grade 5 Spermatic Cord Perforation, CTCAE


Primary acquired melanosis

A spectrum of neoplastic changes that occur in the conjunctiva and range from melanocytic hyperplasia through degrees of atypia to melanoma in situ. The lesions are generally unilateral but often multifocal and appear as flat, irregular brown discolorations of the conjunctiva. They usually affect middle-aged and elderly Caucasians. (WHO 2018)


Mediastinal Hemorrhage

Bleeding originating from the mediastinum.


Upper Airway Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Grade 5 Hypoxia, CTCAE

Death


Grade 2 Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Gallbladder Goblet Cell Carcinoid

An invasive mixed adenoneuroendocrine carcinoma of the gallbladder characterized by the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.


Post-Study Adverse Event

An adverse event that occurred after the patient had completed a clinical study (including any protocol-required post-treatment follow-up).


High Grade Prostatic Intraepithelial Neoplasia, Small Cell Neuroendocrine Variant

High grade prostatic intraepithelial neoplasia characterized by the presence of small neuroendocrine cells in the affected glands.


Grade 3 Uterine Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Locally Advanced Ampulla of Vater Carcinoma

Carcinoma that arises from the ampulla of Vater and has spread to nearby tissues or lymph nodes.


Grade 4 Infantile Apnea, AE

An apneic adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; (semi-)urgent intubation required.


Intraoperative Respiratory Injury

Damage to the respiratory system during a surgical procedure.


Pleural Infection, CTCAE

A disorder characterized by an infectious process involving the pleura.


Grade 2 CNS Necrosis and Cystic Progression, CTCAE


Grade 5 Ileal Perforation, CTCAE

Death


Grade 3 Breast Pain, CTCAE

Severe pain; limiting self care ADL


Monomorphic Post-Transplant Lymphoproliferative Disorder

A clonal lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed lymphocytes or plasma cells.  It includes two variants: monomorphic B-cell and monomorphic T/NK cell post-transplant lymphoproliferative disorders.


Grade 4 Respiratory Failure, CTCAE

Life-threatening consequences; urgent intervention, intubation, or ventilatory support indicated


Grade 4 Oral Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Laryngopharyngeal Dysesthesia, CTCAE

Mild symptoms; no anxiety; intervention not indicated


Grade 4 Lower Extremity Soft Tissue Necrosis, CTCAE


Grade 1 Spasticity, CTCAE

Mild or slight increase in muscle tone


Zoonotic Spillover

Transmission of an infectious disease from a reservoir vertebrate population with a high pathogen prevalence coming into contact with a naive human population.


Grade 5 Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Lower Extremity Vein Intra-Operative Injury, CTCAE


Pathologic Stage IV Retinoblastoma AJCC v8

Stage IV includes: Any pT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


EBV-Associated Smooth Muscle Tumor

A rare smooth muscle neoplasm of uncertain biological potential. It is associated with Epstein-Barr virus infection and seen in patients with immunodeficiency, including primary immunodeficiency, HIV/AIDS infection, and post-transplant immunosuppression.


Grade 5 Soft Tissue Infection, CTCAE

Death


Thoracic Duct Intra-Operative Injury, CTCAE


Grade 3 Bronchial Stricture, CTCAE

Shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement)


Locally Advanced Carcinoma

A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Chest Pain Along Left Middle Sternal Border

The location of the chest pain is along the left middle border of the sternum.


Grade 1 Pharynx Intra-Operative Injury, CTCAE


Grade 5 Oral Cavity Fistula, CTCAE

Death


Myocardial degeneration

Degeneration of myocardial tissue.


Grade 2 Cervical Spine Range of Motion, CTCAE


Astler-Coller C2 Colon Carcinoma

Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


Postneoadjuvant Therapy Stage IVB Esophageal Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Gastrinoma, malignant

A gastrin-producing neuroendocrine tumor.  It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome.  It displays vascular invasion and metastasizes to other anatomic sites.


Congenital Defects of Phagocyte Number, Function, or Both

A group of diseases or disorders caused by genetic defects within the immune system and comprising: Congenital neutropenia; Defects of motility; Defects of respiratory burst; and other nonlymphoid defects.


Neonatal Convulsion, AE

An adverse event in a newborn characterized by sudden, involuntary, rapid rhythmic or stereotyped skeletal muscular contraction.


Grade 1 Ovarian Rupture, CTCAE

Asymptomatic clinical or diagnostic observations only; intervention not indicated


Megakaryocytic Neoplasm

A neoplasm affecting cells of the megakaryocytic lineage.


Grade 4 Neonatal Convulsion, AE

An adverse event in a newborn characterized by suspected seizures with life-threatening consequences (e.g. need for ventilation); suspected status epilepticus (greater than 30 minutes of convulsions within any 60 minute period) despite multiple anti-seizure drugs.


Grade 1 Esophageal Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Pyramidal Tract Syndrome, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 1 Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Grade 2 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Blood Lactate Dehydrogenase Increased, CTCAE

>ULN


Grade 3 Gastric Necrosis, CTCAE

Inability to aliment adequately by GI tract; invasive intervention indicated


Grade 2 Tongue Intra-Operative Injury, CTCAE


Acidosis, CTCAE

A disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues.


Chronic Cutaneous Graft Versus Host Disease

Chronic graft versus host disease (GvHD) occurring in the skin.


Injury of bronchus

Trauma to the lung bronchi.


Malignant melanoma in junctional nevus

A melanoma arising from a melanocytic nevus which involves the dermal-epidermal junction of the skin.


Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


Grade 5 Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Serum Hypertriglyceridemia, CTCAE


Recurrent Cancer of Gallbladder

The reemergence of gallbladder carcinoma after a period of remission.


Grade 5 Mediastinal Infection, CTCAE

Death


Grade 1 Outer Ear Pinna Intra-Operative Injury, CTCAE


INR Increased, CTCAE

A finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood.


Orbivirus infection

An infection that is caused by Orbivirus.


Phlebitis, CTCAE

A disorder characterized by inflammation of the wall of a vein.


Grade 1 Pancreatic Endocrine Glucose Intolerance, CTCAE


Unclassified Hepatocellular Adenoma

A hepatocellular adenoma without distinguished morphologic characteristics or known molecular abnormalities.


Grade 4 Eye Disorders - Other, Specify, CTCAE

Sight-threatening consequences; urgent intervention indicated; best corrected visual acuity of 20/200 or worse in the affected eye


Grade 1 Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


Grade 2 Cranial Nerve II Intra-Operative Injury, CTCAE


Grade 5 Jejunal Fistula, CTCAE

Death


Gastric Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the stomach.


Grade 4 Gastric Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Congenital arteriovenous malformation of gastrointestinal tract

A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the gastrointestinal tract.


Serum Amylase Increased, CTCAE

A finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen.


Grade 2 Fetal Growth Retardation, CTCAE

<10% percentile of weight for gestational age


Grade 2 Upper Gastrointestinal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 2 Phantom Pain, CTCAE

Moderate pain; limiting instrumental ADL


Increased Fibroblast Growth Factor Pathway Activation

A finding indicating increases in fibroblast growth factor (FGF) activity, activation of FGF-dependent pathways and proliferation of cells in a cellular sample.


Adverse event following immunization

Any unfavorable or unintended symptom, sign, or disease including an abnormal laboratory finding) temporally associated with the previous administration of vaccine(s) that may or may not be considered related to the vaccine administration. Such events can be intervention related, dose related, route related, patient related, or caused by an interaction with other product(s) or procedure(s).


Grade 3 Non-Malignant Pleural Effusion, CTCAE


Grade 1 Hoarseness, CTCAE

Mild or intermittent voice change; fully understandable; self-resolves


Tracheostomy Site Bleeding, CTCAE

A disorder characterized by bleeding from the tracheostomy site.


Contact dermatitis due to acid

Contact dermatitis caused by exposure to acids.


Congenital His bundle tachycardia

A congenital disorder characterized by an electrocardiographic finding of tachycardia that affects neonates and infants. It results from an increased automaticity in the atrioventricular node and His bundle.


Extracranial Solid Neoplasm

A solid neoplasm involving any anatomic site other than the brain.


Grade 4 Heart Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Tumor Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


High Metal Ion Levels

High blood or serum levels of ions which are attributed to one or more medical devices used, such as but not limited to Co, Cr, Ti, Ni, Mo.


Pancreatic Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures).


Adenocarcinoma endometrial recurrent

The reemergence of endometrioid adenocarcinoma after a period of remission.


Grade 2 Intraoperative Head and Neck Injury, CTCAE

Partial resection of injured organ/structure indicated


A myelodysplastic/myeloproliferative neoplasm arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders.


Adult Favorable Prognosis Hodgkin Lymphoma

A Hodgkin lymphoma with favorable prognosis that occurs during adulthood.


Grade 5 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Unresectable Mucosal Melanoma

Mucosal melanoma that is not amenable to surgical resection.


Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Shingles, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated; limiting self-care ADL


Grade 2 Fever Without Neutropenia, CTCAE


Metastatic malignant neoplasm to soft tissues

A malignant neoplasm that has spread to the soft tissues from another anatomic site.


Grade 1 Colonic Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Cranial Nerve III Neuropathy, CTCAE


Grade 1 Gastrointestinal Leak NOS, CTCAE


Grade 5 Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Uterine Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


A2/3 Hydronephrosis

Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of greater than or equal to 7mm at less than 28 weeks, 2) greater than or equal to10 mm at greater than or equal to 28 weeks, or 3) any one of the following findings: a)dilation of peripheral calyces, b) abnormal parenchymal thickness or appearance, c) visibly dilated ureter, d) an abnormal bladder, or e) the presence of oligohydramnios suspected to be related to the urinary tract. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Laryngospasm, CTCAE

A disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords.


Grade 4 Fallopian Tube Hemorrhage, CTCAE


Grade 4 Otitis Externa, CTCAE

Life-threatening consequences; urgent intervention indicated


Carcinoma Unspecified Site

Carcinoma in which the site of involvement is not specified.


Locally Advanced Gallbladder Carcinoma

Gallbladder carcinoma that has spread to nearby tissues or lymph nodes.


Grade 4 Flashing Lights and Floaters in Vision, CTCAE


Grade 2 Phlebitis Infective, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage I Adult Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Grade 3 Brain Intra-Operative Injury, CTCAE


Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage II Esophageal Cancer AJCC v7

Stage II includes: For squamous cell carcinoma: IIA (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X); IIB (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIA (T2, N0, M0, G3); IIB (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Grade 2 Ventricular Arrhythmia, CTCAE

Non-urgent medical intervention indicated


Posterior Subcapsular Cataract Grade 2

A stage of posterior subcapsular cataract characterized by 30% of the posterior capsule obscured by opacity. (Modified LOCS II)


Hypophysitis, CTCAE

A disorder characterized by inflammation and cellular infiltration of the pituitary gland.


Grade 5 Hemorrhoidal Hemorrhage, CTCAE

Death


Grade 3 Investigations - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Splenic Infection, CTCAE

A disorder characterized by an infectious process involving the spleen.


ASS1 Gene Deficiency

A genetic finding indicating that low expression of the ASS1 gene has been detected in a sample.


Blood and Lymphatic System Disorders - Other, Specify, CTCAE


Grade 3 Intraoperative Hemorrhage, CTCAE

Postoperative invasive intervention indicated; hospitalization


Cannabis dependence, continuous

Physical and psychological dependence on the drug cannabis, which is associated with a pattern of continuous use.


Creatinine Increased, CTCAE

A finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen.


Grade 2 Pulmonary Fibrosis, CTCAE

Evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25-50% associated with hypoxia


Other Sexual Reproductive Function, CTCAE


Locally Advanced Gastric Adenocarcinoma

A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 4 Spine Kyphosis or Lordosis, CTCAE


Grade 2 Peritoneal Cavity Intra-Operative Injury, CTCAE


Anal Canal Neuroendocrine Tumor G1

A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Grade 5 Intraoperative Urinary Injury, CTCAE

Death


Bile Duct Biliary Intraepithelial Neoplasia

A neoplastic, non-invasive lesion that affects the intrahepatic or extrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Grade 3 Gastrointestinal Pain, CTCAE

Severe pain; limiting self care ADL


Locally Advanced Sarcoma

Sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 4 Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Hypohidrosis, CTCAE

Death


Locally Advanced Unresectable Bone Sarcoma

A bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Borderline Fallopian Tube Neoplasm

A rare epithelial tumor arising from the fallopian tube without definitive morphologic characteristics of malignancy.  This category includes borderline mucinous and serous neoplasms and borderline endometrioid tumor.


Grade 2 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Recurrent Endometrial Serous Adenocarcinoma

The reemergence of endometrial serous adenocarcinoma after a period of remission.


Platinum-Refractory Fallopian Tube Carcinoma

Fallopian tube carcinoma that progresses during platinum therapy or within one month of completing the last platinum therapy.


Haptoglobin Decreased, CTCAE

A finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen.


Mild Adverse Event

An experience that is usually transient, and requires no special treatment or intervention. The event does not generally interfere with usual daily activities. Includes transient laboratory test alterations.


Stage IV Skin Cancer

Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T Any, N3, M0); (T4, N Any, M0); (T Any, N Any, M1).  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T4: Tumor with invasion of skeleton or perineural invasion of skull base.  N0: No regional lymph node metastasis.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M1: Distant metastases.  (AJCC 7th Ed.)


Shared Paranoid Disorder

A disorder in which a delusion develops in an individual in the context of close relationship with another person who already has that established delusion, most likely as the consequence of schizophrenia or delusional disorder.


Sebaceoma

A benign sebaceous neoplasm arising in the deep dermis.


Breast Papillary Neoplasm

A benign or malignant papillary neoplasm that arises from the breast.  It is characterized by the presence of epithelial proliferations that are supported by fibrovascular cores.  Representative examples are intraductal papilloma and papillary carcinoma.


Grade 2 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Grade 2 Artery NOS Intra-Operative Injury, CTCAE


Castleman Disease, Hyaline-Vascular Type

The commonest type of Castleman disease. It is seen most commonly in the mediastinum. Histologically this is characterized by hyalinized germinal centers surrounded by small lymphocytes in a concentric fashion, giving an onion skin appearance.


Infiltrating Bladder Urothelial Carcinoma with Giant Cells

An infiltrating urothelial carcinoma of the bladder with giant cells.


Grade 1 Hypothyroidism, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Spinal Cord Compression, CTCAE

Severe symptoms; limiting self care ADL


Grade 1 Urinary Tract Obstruction, CTCAE


Childhood Classic Hodgkin Lymphoma

A classic Hodgkin lymphoma that occurs during childhood.


Grade 2 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Pelvic hemorrhage

Bleeding within the pelvic cavity.


Unresectable Digestive System Neuroendocrine Neoplasm

A digestive system neuroendocrine neoplasm that is not amenable to surgical resection.


Grade 3 Leukoencephalopathy, CTCAE

Severe symptoms; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly


Enteroglucagonoma

An endocrine neoplasm producing glucagon.


Grade 2 Injury To Superior Vena Cava, CTCAE

Symptomatic; repair or revision not indicated


Grade 2 Ileal Ulcer, CTCAE

Symptomatic; altered GI function


Grade 3 Myelitis, CTCAE

Severe weakness or sensory loss; limiting self care ADL


Grade 1 Restlessness, CTCAE

Mild symptoms; intervention not indicated


Grade 1 Laryngeal Inflammation, CTCAE

Mild sore throat; raspy voice


Recurrent Nevus

A nevus that recurs after incomplete surgical removal, biopsy, or trauma. (WHO 2018)


Venomous Animal Contact

Contact with a venomous animal.


Locally Advanced Squamous Cell Carcinoma

A squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Fallopian Tube Perforation, CTCAE

Invasive intervention indicated


Grade 4 Alkalosis, CTCAE

Life-threatening consequences


Grade 4 Neck NOS Intra-Operative Injury, CTCAE


Major Congenital Anomaly

A major congenital anomaly is a structural or functional defect with the following three characteristics: 1) Of prenatal origin; 2) Present at the time of live birth or fetal demise, or in utero; 3) Affecting (or has the propensity to affect) the health, survival, or physical or cognitive functioning of the individual.


Carcinoma of unknown primary

A carcinoma which has metastasized from an unknown primary anatomic site.


Grade 2 Anal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Acute Kidney Injury, CTCAE

A disorder characterized by the acute loss of renal function (within 2 weeks) and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction).


Hematopoietic and Lymphoid Neoplasm (Antiquated)


Grade 3 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Blood Bicarbonate Decreased, CTCAE

A finding based on laboratory test results that indicate a decrease in levels of bicarbonate in a venous blood specimen.


Grade 1 Colonic Fistula, CTCAE

Asymptomatic


Adverse Event with No Consequence or Impact

No apparent harm occurred in relation to the adverse event.


Clinical Chorioamnionitis

Inflammation of the fetal sac membranes, characterized by otherwise unexplained fever (at or above 38 degree C (100.4F)) with one or more of the following: uterine tenderness and/or irritability, leukocytosis, fetal tachycardia, maternal tachycardia, or malodorous vaginal discharge.


Ventral hernia without mention of obstruction or gangrene

The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, without mention of obstruction or necrosis of the herniated contents.


Lumbar meningomyelocele

A congenital abnormality in the lumbar region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Grade 4 Pharyngeal Hemorrhage, CTCAE

Life-threatening consequences; intubation or urgent intervention indicated


Grade 5 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Grade 3 Dysarthria, CTCAE

Severe impairment of articulation or slurred speech


Grade 4 Brachial Plexus Intra-Operative Injury, CTCAE


Adverse Event by CTCAE v4 Severity Grade


Autoimmune Atrophic Chronic Gastritis

Chronic atrophic gastritis that is caused by autoimmune destruction of parietal cells in the stomach resulting in hypochlorhydria and decreased production of intrinsic factor.


Stage I Low-CSD Melanoma AJCC v7

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 3 Papilledema, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200)


Grade 5 Intraoperative Head and Neck Injury, CTCAE

Death


Grade 4 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Central Nervous System Hemorrhage, CTCAE


Grade 4 Intraoperative Gastrointestinal Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Urinary Tract NOS Intra-Operative Injury, CTCAE


Grade 2 Hepatobiliary Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 4 Nails Intra-Operative Injury, CTCAE


Malignant Bladder Paraganglioma

An extra-adrenal sympathetic paraganglioma of the bladder that metastasizes to other anatomic sites.


Grade 2 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Gallbladder Infection, CTCAE

A disorder characterized by an infectious process involving the gallbladder.


Grade 4 Persistent Pulmonary Hypertension of the Newborn, AE

A persistent pulmonary hypertension adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; extracorporeal membrane oxygenation (ECMO) required; oxygenation index greater than 40.


Grade 4 Artery NOS Intra-Operative Injury, CTCAE


Infant Leukemia

An acute lymphoblastic or acute myeloid leukemia that occurs in infancy.


Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Complication due to Medical/Surgical Care

An untoward event that can be attributed to care received during a medical/surgical event.


Ancylostomiasis due to Ancylostoma ceylonicum (disorder)

Infection by Ancylostoma ceylanicum.


Distal Esophagus Adenocarcinoma

An adenocarcinoma arising from the lower third of the esophagus. The vast majority of esophageal adenocarcinomas involve the lower third of the esophagus.


Grade 3 Rectal Necrosis, CTCAE

Tube feeding or TPN indicated; invasive intervention indicated


Grade 2 Peripheral Sensory Neuropathy, CTCAE

Moderate symptoms; limiting instrumental ADL


Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Neonatal Intraventricular Hemorrhage, AE

An adverse event in a newborn characterized by hemorrhage occupying less than 50% of ventricular volume without ventricular dilatation greater than 4mm above the 97th percentile.


Elevated EBV DNA

A finding indicating elevated concentrations of Epstein-Barr virus DNA in a sample.


Cervical intraepithelial neoplasia grade 1

Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Diffuse KATP-Associated Hyperinsulinism

KATP-associated hyperinsulinism affecting all pancreatic beta cells.


Recurrent Acute Erythroid Leukemia

The reemergence of acute erythroid leukemia after a period of remission.


Anxiety disorder due to a general medical condition

An anxiety disorder in which the symptoms of anxiety have been determined to be the direct physiological consequence of a general medical condition.


Aspiration, CTCAE

A disorder characterized by inhalation of solids or liquids into the lungs.


Grade 2 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Stage IVB Cervical Cancer FIGO 2009

Cervical carcinoma involving distal organs outside the pelvis. (FIGO 2009)


Basal cell carcinoma - keratotic

A variant of basal cell carcinoma with the architectural features of a nodular basal cell carcinoma.  It is characterized by the formation of keratin (horn cysts) in the center of the tumor islands.  Dystrophic calcification is frequently present.


Grade 5 Pyramidal Tract Dysfunction, CTCAE


Grade 4 Bronchopleural Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Complication

Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure.


Anaplastic Diencephalic Astrocytoma

An anaplastic astrocytoma that occurs in the diencephalon.


Grade 4 Respiratory Tract Hemorrhage NOS, CTCAE


A reactive proliferation of the conjunctival squamous epithelium not associated with glandular elements.


Philadelphia Chromosome Negative BCR-ABL1 Negative Chronic Myelogenous Leukemia


Grade 2 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Lymphoproliferative Disease Associated with Primary Immune Disorder

A lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder. The primary immune disorders most frequently associated with lymphoproliferative disorders are ataxia-telangiectasia, Wiskott-Aldrich syndrome, common variable immunodeficiency, severe combined immunodeficiency, X-linked lymphoproliferative disease, Nijmegen breakage syndrome, hyper-IgM syndrome, and autoimmune lymphoproliferative syndrome. (WHO 2017)


Grade 4 Leukocytosis, CTCAE

Clinical manifestations of leucostasis; urgent intervention indicated


Grade 2 Bladder Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Radiating Chest Pain Along Right Lower Sternal Border

The location of the radiating chest pain is along the right lower sternal border.


Recurrent Histiocytic and Dendritic Cell Neoplasm

The reemergence of a histiocytic and dendritic cell neoplasm after a period of remission.


Grade 1 Pancreatic Fistula, CTCAE

Asymptomatic


Stage III Childhood Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Vascular anomaly of eyelid

Any non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels of the eyelid.


Stage III Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0). T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. T3: Tumor of any size with invasion into surrounding tissues (e.g., liver, pancreas, spleen, kidneys). N1: Regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Stage IIIA Esophageal Adenocarcinoma AJCC v7

Stage IIIA includes: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Oligospermia, CTCAE

A disorder characterized by a decrease in the number of spermatozoa in the semen.


Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Grade 3 Appendix Intra-Operative Injury, CTCAE


verrucous carcinoma of vagina

A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, acanthotic epithelium with minimal or absent atypia, and pushing borders.


Elevated LDH

An indication that the concentration of lactate dehydrogenase found in a sample is higher than previous noted or above the normal range.


Grade 1 Injection Site Reaction, CTCAE

Tenderness with or without associated symptoms (e.g., warmth, erythema, itching)


Grade 4 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Injection Site Reaction, CTCAE

Death


Grade 5 Laryngeal Stenosis, CTCAE

Death


Grade 4 Blood Bilirubin Increased, CTCAE

>10.0 x ULN if baseline was normal; >10.0 x baseline if baseline was abnormal


Grade 1 Lower Extremity Intra-Operative Injury, CTCAE


Testicular Seminoma with Syncytiotrophoblastic Cells

A testicular seminoma characterized by the presence of syncytiotrophoblastic giant cells.


Peritoneal Implant

Deposits of borderline, malignant, and rarely benign tumors, usually from the ovary, on the peritoneal surface.


Grade 1 Anorgasmia, CTCAE

Inability to achieve orgasm not adversely affecting relationship


Infections and Infestations - Other, Specify, CTCAE


Sinusitis, CTCAE

A disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses.


Grade 2 Recurrent Laryngeal Nerve Palsy, CTCAE

Moderate symptoms


Grade 4 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Cranial Nerve VI Intra-Operative Injury, CTCAE


Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

An acute myeloid leukemia with recurrent genetic abnormalities occurring in adults.


High Grade Liver Dysplastic Nodule

A hepatic dysplastic nodule characterized by the presence of high grade atypical cellular changes.


Sporadic Gastric Adenocarcinoma

A primary adenocarcinoma of the stomach in a patient with no family history of gastric cancer or inherited high risk mutations.


Subacute Placental Infarction

A focus of necrotic placental parenchyma with moderate hyalinization and fibrosis with partial absence of the necrotic chorionic villi, which is frequently 3-5 days of duration.


K ATP Permanent Neonatal Diabetes

K ATP channel-associated neonatal diabetes mellitus that does not resolve spontaneously.


Grade 5 Superior Vena Cava Syndrome, CTCAE

Death


Resectable Sarcoma

Sarcoma that is amenable to surgical resection.


Periorbital Edema, CTCAE

A disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face.


Grade 3 Renal and Urinary Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Accident

An unforeseen and unplanned event or circumstance frequently causing loss or injury.


Clinical Stage I Cutaneous Melanoma AJCC v8

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 2 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Laryngeal Nerve Dysfunction, CTCAE


Grade 3 Hemolytic Uremic Syndrome, CTCAE

Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae)


Grade 2 Cranial Nerve VIII Intra-Operative Injury, CTCAE


Endometrial cystic hyperplasia

Benign endometrial hyperplasia characterized by the presence of cystically dilated glands.


Pulmonary Fibrosis Radiographic Changes, CTCAE


Grade 2 Pancreas Exocrine Enzyme Deficiency, CTCAE


Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Otitis Externa, CTCAE

Localized, local intervention indicated


Imaging Finding

The result of an evaluation technique using a visual display of structural or functional patterns of organs or tissues that is performed to determine the presence, absence, or degree of a condition.


Meniscal Cyst

A cyst located at the periphery of the meniscus.


Grade 1 Hypotension, CTCAE

Asymptomatic, intervention not indicated


Grade 3 Neuralgia and Peripheral Nerve Pain, CTCAE


Malignant Lymphoma, Histiocytic, Diffuse


Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE