Sexual Aversion Disorder

A disorder characterized by recurrent or persistent extreme aversion to, and avoidance of, all genital contact with a sexual partner. The aversion to sexual contact is not attributable to another psychiatric disorder.


Gallbladder Tubular Carcinoid

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A neuroendocrine tumor that arises from the gallbladder.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


Grade 2 Breast Volume and Hypoplasia, CTCAE

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Grade 3 Intraoperative Gastrointestinal Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 2 Small Intestinal Mucositis, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Benign Thymoma

A thymoma that is completely surrounded by a capsule, without evidence of capsular invasion, infiltration of the surrounding tissues, and metastases.


Cutaneous Melanoma by AJCC v8 Clinical Stage

A term that refers to the clinical staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


Grade 4 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Proctitis, CTCAE

Severe symptoms; fecal urgency or stool incontinence; limiting self care ADL


Grade 3 Vaginal Perforation, CTCAE

Invasive intervention indicated


Grade 2 Lymph Leakage, CTCAE

Symptomatic; medical intervention indicated


Grade 4 Nephrotic Syndrome, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage IA Cervical Cancer FIGO 2009

Cervical carcinoma measuring equal or less than 5 mm in depth and equal or less than 7 mm in width. (FIGO 2009)


Primary Valvular Disorder

Heart disease that is primarily due to a valvular defect or abnormality. Valve disease that is felt to be significant but does not fulfill the definition for primary valvular heat disease is considered contributory valvular heart disease.


Grade 3 Genitourinary Stoma Obstruction, CTCAE


Merkel Cell Carcinoma by AJCC v7 Stage

A term that refers to the staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v7 classification system.


Complication of transplanted organ, NOS

A disease or disorder that is associated with a transplanted organ.


Grade 2 Hallucinations, CTCAE

Moderate hallucinations


Grade 3 Serum Hypertriglyceridemia, CTCAE


Grade 5 Nervous System Disorders - Other, Specify, CTCAE

Death


Opportunistic Infection Associated with Grade 2 or Greater Lymphopenia, CTCAE


Grade 2 Pain of Skin, CTCAE

Moderate pain; limiting instrumental ADL


Pelvic Undifferentiated High Grade Pleomorphic Sarcoma

Undifferentiated high grade pleomorphic sarcoma  involving the bones of the pelvis.


Grade 2 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Chronic Orthostatic Intolerance

A condition in which there is orthostatic intolerance lasting for at least three months with associated functional impairment. (ACC/AHA)


Grade 3 Scrotal Pain, CTCAE

Severe pain; limiting self care ADL


Recurrent Malignant Urinary System Neoplasm

Reemergence of a malignant urinary system neoplasm after a period of remission.


Grade 4 Hyperphosphatemia, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., dialysis)


Grade 5 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Grade 1 Thyroid Stimulating Hormone Increased, CTCAE

TSH increased and no intervention initiated


Iron deficiency without anemia

Subnormal concentrations of iron resulting from low iron intake, inefficient iron absorption in the gastrointestinal tract, or increased iron loss; occurring in the absence of anemia.


Stage I Esophageal Adenocarcinoma AJCC v7

Stage I includes: IA (T1, N0, M0, G1-2, X); IB (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Grade 3 Alcohol Intolerance, CTCAE

Severe symptoms; limiting self care ADL


Grade 3 Acidosis, CTCAE

pH <7.3


Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8

Stage IIIB includes: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Advanced gastric carcinoma

Gastric carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Refractory Dedifferentiated Liposarcoma

Dedifferentiated liposarcoma that does not respond to treatment.


Flushing, CTCAE 5.0

A disorder characterized by episodic reddening of the skin, especially face, neck, or chest.


Cellulitis of pharynx

Cellulitis of the pharynx.


Grade 2 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


High grade cervical glandular intraepithelial neoplasia

Cervical glandular intraepithelial neoplasia characterized by the presence of severe dysplastic changes.


Grade 3 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Severe Adverse Event

An adverse event experience that requires intensive therapeutic intervention and interrupts usual daily activities.


Extrahepatic bile duct cancer stage III

Stage III includes: T4, Any N, M0.  T4: Tumor invades any of the following main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: Distant metastasis. (AJCC 6th ed.)


Aplastic bone marrow

Depletion of stem cells in the bone marrow that results in the lack of production of hematopoietic cells.


Grade 2 Pleura Intra-Operative Injury, CTCAE


Cerebellar Paraganglioma

An extra-adrenal paraganglioma arising from the cerebellum.


Grade 4 Oral Intra-Operative Injury, CTCAE


Lymphoma by Lukes-Collins Classification (Antiquated)


High Grade Prostatic Intraepithelial Neoplasia

Prostatic intraepithelial neoplasia characterized by the presence of morphologically malignant cells lining the acini and ducts.  The malignant cells are enlarged, contain prominent nucleoli, and have increased nuclear/cytoplasmic ratio.  The malignant cells may grow within the ducts and acini in four architectural patterns: flat, tufting, micropapillary, and cribriform.  The presence of high grade prostatic intraepithelial neoplasia in needle biopsy is a risk factor for the subsequent detection of carcinoma on repeat biopsy.


Grade 5 Intraoperative Renal Injury, CTCAE

Death


Grade 5 Pyramidal Tract Syndrome, CTCAE

Death


Grade 2 Feminization Acquired, CTCAE

Moderate symptoms; medical intervention indicated


Stage IV Ureter Cancer AJCC v7

Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  N1: Distant metastasis.  (AJCC 7th ed.)


Grade 2 Urinary Incontinence, CTCAE

Spontaneous; pads indicated; limiting instrumental ADL


Grade 5 Duodenal Hemorrhage, CTCAE

Death


Grade 4 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Mixed Phenotype Acute Leukemia, B/T/Myeloid, Not Otherwise Specified

A very rare mixed phenotype acute leukemia, not otherwise specified in which the blasts show evidence of trilineage (B-cell, T-cell, and myeloid lineage) assignment. (WHO 2017)


Grade 3 Ileal Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


High Grade Bladder Urothelial Carcinoma

Bladder urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


Grade 3 Hypoxia, CTCAE

Decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg)


EBV-Related Post-Transplant Lymphoproliferative Disorder


Stage I Lentigo Maligna Melanoma AJCC v7

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 3 Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


Lacrimal Drainage System Mucoepidermoid Carcinoma

A carcinoma that arises from the lacrimal sac. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Paratesticular tumor

A benign or malignant neoplasm that affects the paratesticular structures.


Grade 4 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 1 Pulmonary Hypertension, CTCAE

Minimal dyspnea; findings on physical exam or other evaluation


Pathologic Stage III Merkel Cell Carcinoma AJCC v8

Stage III includes: IIIA: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0); IIIB: (T1-4, N1b-3, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Hypothalamic Gangliocytoma

A tumor characterized by the presence of mature ganglion cells and neuronal differentiation, arising in the hypothalamus. It is often associated with the presence of pituitary gland adenomas. Symptoms include acromegaly and precocious puberty.


Solicited Adverse Event

An adverse event that is reported by a healthcare professional, consumer, or patient through an organized data collection system.


Grade 5 Gastrointestinal Stoma Necrosis, CTCAE

Death


AIDS-Related Cervical Carcinoma

A carcinoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


CNS Necrosis and Cystic Progression, CTCAE


First-degree perineal laceration during delivery

Injury to perineal skin only. (reVITALize)


Emaciation

An extreme loss of muscle and subcutaneous fat that is caused by malnutrition, and which results in a severely thin (emaciated) appearance.


Grade 4 Vaginal Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


P1 Hydronephrosis

Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is 10 to less than 15 mm, 2) central calyceal dilation may be present, but peripheral calyceal dilation is considered to increase risk, 3) renal parenchyma should have normal thickness and appearance, 4) the ureter is not seen, and 5) the bladder is normal. If there is central calyceal dilation but the APRPD is less than 10 mm, it is still considered UTD P1. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Anosmia, CTCAE

A disorder characterized by a change in the sense of smell.


Grade 4 Prostate Stricture or Stenosis, CTCAE


Upper Aerodigestive Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 1 Conjunctiva Intra-Operative Injury, CTCAE


Hereditary Transthyretin Amyloid Cardiomyopathy

Transthyretin amyloid cardiomyopathy caused by mutation(s) in the TTR gene, encoding transthyretin.


Grade 4 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Aerodigestive Invasive Malignancy

A finding indicating the presence of an invasive malignant neoplasm involving the respiratory tract and the upper digestive tract.


Grade 4 Bronchopulmonary Dysplasia, AE

An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND need for greater than 30% oxygen AND positive pressure at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; need for greater than 30% oxygen AND positive pressure by 56 days postnatal age in infants born greater than 32 weeks' gestation; need for greater than 30% oxygen AND positive pressure at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


Grade 1 Gastroesophageal Reflux Disease, CTCAE

Mild symptoms; intervention not indicated


Stage IA Pancreatic Cancer AJCC v8

Stage IA includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Urostomy Site Bleeding, CTCAE

A disorder characterized by bleeding from the urostomy site.


Grade 2 Cranial Nerve X Neuropathy, CTCAE


Grade 1 Eye Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated; no change in vision


Hepatic Hemorrhage, CTCAE

A disorder characterized by bleeding from the liver.


Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Necrotizing Enterocolitis, AE

An adverse event in a newborn characterized by confirmed necrotizing enterocolitis; major care change indicated (e.g. NPO, antibiotics, non-urgent surgery).


Substance Intoxication Delirium

A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance intoxication.


Lip Infection, CTCAE

A disorder characterized by an infectious process involving the lips.


Grade 5 Oral Hemorrhage, CTCAE

Death


Stage IIIA Uterine Corpus Cancer AJCC v7

Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Grade 3 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pericarditis, CTCAE

A disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart).


Grade 4 Hypokalemia, CTCAE

<2.5 mmol/L; life-threatening consequences


Grade 4 Lipase Increased, CTCAE

>5.0 x ULN and with signs or symptoms


Grade 3 Fallopian Tube Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Cutaneous Hematopoietic and Lymphoid Cell Neoplasm

A myeloid or lymphoid cell neoplasm involving the skin.


Grade 2 Intraoperative Reproductive Tract Injury, CTCAE

Partial resection of injured organ/structure indicated


Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during adulthood.


Stage IV Vulvar Cancer AJCC v8

Stage IV includes: T1-T3, N3, M0-M1. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


Grade 4 Papulopustular Rash, CTCAE

Life-threatening consequences


Adverse Event Associated with Growth and Development


Shingles, CTCAE

A disorder characterized by the reactivation of herpes zoster virus.


Adverse Event Associated with the Nervous System


Locally Advanced Lymphoma

Lymphoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 4 Visceral Arterial Ischemia, CTCAE

Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


High Grade Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is high grade.


Prostatic Hemorrhage, CTCAE

A disorder characterized by bleeding from the prostate gland.


Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Conditioned Insomnia

Insomnia that results from a developed tendency to not sleep well under particular conditions.


Broad Ligament Serous Cystadenoma

A rare serous cystadenoma arising from the broad ligament.


Grade 3 Aortic Valve Disease, CTCAE

Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention


Grade 3 Jejunal Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated


Adenocarcinoma in situ in villous adenoma

A non-invasive adenocarcinoma arising from a villous adenoma.


Childhood Gemistocytic Astrocytoma

A gemistocytic astrocytoma that occurs during childhood.


Grade 1 Trachea Intra-Operative Injury, CTCAE


Vaginal Mesonephric Adenocarcinoma

Vaginal adenocarcinoma that derives from Wolffian duct remnants and shows mesonephric differentiation.


FIGO Stage IIB Gestational Trophoblastic Tumor


Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Adult Acquired Toxoplasmosis

Toxoplasmosis acquired in adulthood.


High Grade Sarcoma

A sarcoma with the morphologic features of a high grade tumor and lack of differentiation.


Grade 4 Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Conduction Disorder, CTCAE

A disorder characterized by pathological irregularities in the cardiac conduction system.


Grade 2 Pharyngeal Mucositis, CTCAE

Moderate pain, analgesics indicated; altered oral intake; limiting instrumental ADL


Grade 4 Extrapyramidal Disorder, CTCAE

Life-threatening consequences; urgent intervention indicated


Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Uterus Stricture or Stenosis, CTCAE


Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Infusion Related Toxicity

Toxicity related to an infusion.


Locally Recurrent Malignant Neoplasm

The reemergence of a malignant neoplasm after a period of remission at the site of the original tumor or adjacent to it.


Pediatric Obesity

A condition in which a child's body mass index (BMI) falls at or above the 95th percentile based on the normative values for the age and sex of the reference population.


Grade 5 Abdominal Infection, CTCAE

Death


Cerebellar Glioblastoma

A glioblastoma that occurs in the cerebellum.


Grade 4 Sinus Disorder, CTCAE

Necrosis of soft tissue or bone; urgent operative intervention indicated


Acute Lymphoblastic Leukemia by ROSE Cluster

Unique gene expression-based patient cluster groups in high-risk B-precursor acute lymphoblastic leukemia determined by Recognition of Outliers by Sampling Ends (ROSE).


Bilateral Proliferative Retinopathy

Proliferative retinopathy occurring in both eyes.


Grade 2 Duodenum Stricture or Stenosis, CTCAE


Stage IVB Bone Cancer AJCC v7

Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 2 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Ureter Stricture or Stenosis, CTCAE


Cervix Intraepithelial Neoplasia Grade 3 AJCC v7

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Umbilical hernia without mention of obstruction or gangrene

The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the umbilicus, without mention of obstruction or necrosis of the herniated contents.


Grade 2 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Locally Advanced Cervical Adenocarcinoma

A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Non-small cell carcinoma

A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma.


Tumors Derived from Langerhans Cells

This category includes two main sub-groups, according to the degree of cytological atypia and clinical aggressiveness: Langerhans cell histiocytosis and Langerhans cell sarcoma. (WHO 2017)


Racial Melanosis

A benign conjunctival finding noted especially among darker pigmented individuals. While it is typically found perilimbally and bilaterally, it can also cover the conjunctivae extensively and may present asymmetrically. The flat, non-cystic pigmentation may increase in size with age. It is rare to have this finding evolve into conjunctival melanoma.


Grade 5 Tracheal Obstruction, CTCAE

Death


Broad Ligament Wolffian Tumor

An epithelial neoplasm of Wolffian (mesonephric) origin arising from the broad ligament. Most tumors behave in a benign fashion.


Grade 1 Tendon Reflex Decreased, CTCAE

Ankle reflex reduced


Grade 3 Central Nervous System Hemorrhage, CTCAE


Grade 4 Genitourinary Stoma Obstruction, CTCAE


Pathologic Stage IIID Cutaneous Melanoma AJCC v8

Stage IIID includes: T4b, N3a/b/c, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 3 Intraoperative Neurological Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 1 Duodenum Stricture or Stenosis, CTCAE


Recurrent Acute Promyelocytic Leukemia with PML-RARA

The reemergence of acute promyelocytic leukemia with PML-RARA after a period of remission.


Chest Pain - Cardiac, CTCAE

A disorder characterized by substernal discomfort due to insufficient myocardial oxygenation e.g., angina pectoris.


Grade 3 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Atelectasis, CTCAE

Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Grade 2 Agitation, CTCAE

Moderate mood alteration


Midgut Neuroendocrine Tumor

A well differentiated, low, intermediate, or high grade neoplasm that arises from the jejunum, ileum, proximal colon, or appendix.


Grade 1 Muscular and Skeletal Hypoplasia, CTCAE


Grade 3 Retroperitoneum Hemorrhage, CTCAE


Idiopathic Dysplasia of Uncertain Significance

Prominent hematopoietic cell dysplasia with mild or absent cytopenia. It may progress to an overt myelodysplastic syndrome or other myeloid neoplasms such as acute myeloid leukemia, myeloproliferative neoplasm, or mast cell disorder.


Schizophrenia and other psychotic disorders

A category of psychiatric disorders characterized by the presence of psychotic symptoms such as delusions or hallucinations or negative symptoms such as affective flattening.


Tubal Hyperplasia

Benign proliferation of the fallopian tube epithelium.


Grade 3 Concentration Impairment, CTCAE

Severe impairment in attention or decreased level of concentration; limiting self care ADL


Atrioventricular Block Complete, CTCAE

A disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles.


Abnormal Finding

A decision that an observation or result is outside the parameters considered normal.


Trichilemmal carcinoma

A rare malignant tumor arising from the outer hair sheath and infundibulum on the face. It is considered the malignant counterpart of tricholemmoma. Complete surgical excision is required.


Grade 3 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Stage IIIB Vulvar Cancer AJCC v7

Stage IIIB includes: (T1/T2, N2a/N2b, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less.  N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Carbon Monoxide Diffusing Capacity Decreased, CTCAE

Asymptomatic decrease of >8 units drop; >5 units drop along with the presence of pulmonary symptoms (e.g., >Grade 2 hypoxia or >Grade 2 dyspnea); intervention indicated


Low Grade Gastric Intraepithelial Neoplasia

A gastric intraepithelial lesion characterized by the presence of neoplastic cells with mild cytologic atypia, mild architectural changes, and low number of mitotic figures.


Laryngeal Hemorrhage, CTCAE

A disorder characterized by bleeding from the larynx.


Anaplastic Large Cell Lymphoma, Lymphomatoid Papulosis-Like Histology

An anaplastic large cell lymphoma characterized by the presence of histopathologic features reminiscent of lymphomatoid papulosis. These features include the presence of Hodgkin-like cells in a background of acute and chronic inflammation.


Grade 3 Ascites, CTCAE

Severe symptoms; invasive intervention indicated


Sinus Tachycardia, CTCAE 5.0

A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node.


Hodgkin's disease, lymphocytic depletion of lymph nodes of multiple sites

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Adenocarcinoma of the prostate stage III

Stage III includes: T3a-b, N0, M0, Any PSA, Any Gleason.  cT3a: Tumor with extracapsular extension (unilateral or bilateral).  pT3a: Tumor with extraprostatic extension or microscopic invasion of bladder neck.  T3b: Tumor invades seminal vesicle(s).  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Neonatal Intraventricular Hemorrhage, AE

An adverse event in a newborn characterized by bleeding into the lateral cerebral ventricles.


Grade 3 Peritoneal Cavity Intra-Operative Injury, CTCAE


Grade 1 Pleuritic Pain, CTCAE

Mild pain


Erosion lesion

An eating away or breakdown of any type of external or internal human tissue including but not limited to skin, teeth, mucosa, or somatic, which involves only the outer tissue layer. When tissue surrounds an implanted device, the tissue breakdown may result in migration and loss of the implant material and may result in further complications such as infection or abscess.


Grade 1 Myelitis, CTCAE

Asymptomatic; mild signs (e.g., Babinski's reflex or Lhermitte's sign)


Unresectable Ampulla of Vater Carcinoma

Carcinoma that arises from the ampulla of Vater and is not amenable to surgical resection.


Grade 3 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Biliary Tract Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 5 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Carcinoma Metastatic to the Skin

A carcinoma that has spread to the skin from its original site of gowth.


Testicular Non-Neoplastic Disorder

A non-neoplastic disorder that affects the testis.  Representative examples include infection, torsion, and infarction.


Grade 3 Injury To Inferior Vena Cava, CTCAE

Severe symptoms; limiting self care ADL; repair or revision indicated


Endocrine Disorders - Other, Specify, CTCAE


Mucosal Infection, CTCAE

A disorder characterized by an infectious process involving a mucosal surface.


Grade 3 Hematoma, CTCAE

Transfusion; invasive intervention indicated


Advanced Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Metastatic Melanoma

Metastatic melanoma that is resistant to treatment.


Stage IV Bone Sarcoma AJCC v7

Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 5 Fallopian Tube Obstruction, CTCAE


Pancreatic Hepatoid Adenocarcinoma

A rare adenocarcinoma that arises from the pancreas.  It is characterized by marked hepatocellular differentiation.


Stage I Ampulla of Vater Cancer AJCC v8

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2, N0, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Other Dermatology or Skin, CTCAE


Mammary duct ectasia

Dilatation of the lumen of the mammary ducts without evidence of epithelial atypia.


Grade 3 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Kidney Pain, CTCAE

Kidney pain that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


Grade 4 Urethral Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Non-Muscle Invasive Bladder Urothelial Carcinoma

An infiltrating urothelial carcinoma of the bladder that has not invaded into the bladder muscularis propria.


Cranial Nerve VIII Intra-Operative Injury, CTCAE


Grade 1 Prolapse of Intestinal Stoma, CTCAE

Asymptomatic; reducible


Grade 5 Surgical and Medical Procedures - Other, Specify, CTCAE

Death


Grade 1 Gallbladder Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Non-Invasive Cribriform Carcinoma

A carcinoma characterized by the presence of a cribriform architectural pattern. There is no evidence of surrounding stromal invasion by the malignant cells.


Chronic Myelomonocytic Leukemia with Eosinophilia Associated with t(5;12)(q31;p12)

Chronic myelomonocytic leukemia characterized by the presence of eosinophilia, PDGFRB gene rearrangement, and t(5;12)(q31;p12).


Grade 1 Platelet Count Decreased, CTCAE

<LLN-75,000/mm3; <LLN-75.0 x 10e9/L


Stage IVB Oral Cavity Verrucous Carcinoma


Stage IVA Gallbladder Cancer AJCC v8

Stage IVA includes: T4, N0-1, M0. T4: Tumor invading the main portal vein or hepatic artery or invading two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 3 Aspartate Aminotransferase Increased, CTCAE

>5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


Grade 4 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Urinary Tract Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Mitochondrial Uncoupling Protein 2 Hyperinsulinism

Hyperinsulinism due to mutation(s) in the gene UCP2, encoding mitochondrial uncoupling protein 2, which plays a role in attenuating insulin secretion.


Supratentorial Ependymoma

A circumscribed ependymoma that arises from the supratentorial region of the brain. The diagnosis of supratentorial ependymoma should be made either when genetic analysis did not reveal a fusion gene involving ZFTA or YAP1 genes (not elsewhere classified -NEC) or when the genetic analysis was unsuccessful or not reported (not otherwise specified-NOS).


Pediatric Disorder

A non-neoplastic or neoplastic disorder which occurs during infancy, childhood, or adolescence.


Grade 4 Atrioventricular Block Complete, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Renal Colic, CTCAE

Hospitalization indicated; limiting self care ADL


Grade 5 Pleural Effusion, CTCAE

Death


Grade 4 Spinal Fracture, CTCAE

Life-threatening consequences; symptoms associated with neurovascular compromise


Grade 1 Major Visceral Artery Intra-Operative Injury, CTCAE


Grade 4 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Uterine Fistula, CTCAE

A disorder characterized by an abnormal communication between the uterus and another organ or anatomic site.


Grade 1 Breast Volume and Hypoplasia, CTCAE


Grade 3 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Libido Increased, CTCAE

A disorder characterized by an increase in sexual desire.


Columnar Cell Change of the Breast with Atypia

A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by one or two layers of columnar epithelial cells.  Cytologic atypia is present.


Grade 3 Cranial Nerve IV Intra-Operative Injury, CTCAE


Grade 1 Teeth Intra-Operative Injury, CTCAE


Grade 5 Hypophysitis, CTCAE

Death


Grade 2 Glaucoma, CTCAE

EIOP which can be reduced to 21 mmHg or under with topical medications and no visual field deficit


Grade 2 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Ear and Labyrinth Disorders - Other, Specify, CTCAE


Body Odor, CTCAE

A disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body.


Asymptomatic Inflammatory Prostatitis

Inflammation of the prostate gland that is not associated with any symptoms. It is characterized by the presence of inflammatory cells in the prostatic fluid.


Extramural Nodule

A small aggregate of cells found in adipose tissues, particularly those attached to the colon where the architectural details of the lymph node cannot be identified with certainty under the microscope.  It may represent a lymph node completely replaced by metastatic cancer.


Complete unbalanced atrioventricular canal defect

Atrioventricular septal defect in which there is usually a single dominant ventricle and a hypoplastic ventricle.


Refractory Cytomegalovirus Infection

A cytomegalovirus infection that is resistant to treatment.


Grade 5 Malabsorption, CTCAE

Death


Liver Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the liver. The Ki-67 index is higher than 20%.


Serum Glutamic Pyruvic Transaminase, CTCAE


AIDS-Related Diffuse Large Cell Lymphoma

A diffuse large cell lymphoma developing in an HIV positive patient.


Grade 2 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Fat Atrophy, CTCAE

Covering >30% BSA; associated with erythema or tenderness; limiting self-care ADL


Grade 2 Oral Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Deletion of Chromosome 22 Associated Meningioma

A meningioma that is associated with deletion of chromosome 22.  This abnormality is the most consistent cytogenetic finding that is detected in meningiomas.


Mouth cyst

A cystic lesion located in the oral cavity.


Grade 5 Conduction Disorder, CTCAE

Death


Stage IB Merkel Cell Carcinoma AJCC v7

Stage IB includes: T1, cN0, M0.  T1: Primary tumor equal or less than 2 cm in size.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Erectile Dysfunction, CTCAE

A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity.


Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IV Ampulla of Vater Cancer AJCC v7

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis.  (from AJCC 7th Ed.)


FEV1, CTCAE

An adverse event marked by a change in FEV1 lung function.


Grade 1 Spermatic Cord Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Bone Schwannoma

A very rare schwannoma of the bone. It is often located in the mandible and is well circumscribed.


Grade 1 Lens Intra-Operative Injury, CTCAE


Esophageal dysplasia

A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma.  Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade.  In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications.  (WHO, 2000)


Melanocytic matricoma

A rare benign pilar tumor with numerous intratumoral pigmented dendritic melanocytes. It typically affects elderly men. The most common location is the head and neck, followed by the trunk and the limbs. It manifests as a small, pigmented, purple or brownish-black papule or nodule. (WHO 2018)


Grade 3 Proptosis and Enophthalmos, CTCAE


Stage II Vaginal Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor invades paravaginal tissues but not to pelvic wall.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Uterine Infection, CTCAE

A disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues.


Precursor T-lymphoblastic lymphoma/leukemia stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in a with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Radiating Chest Pain Along Left Lower Sternal Border

The location of the radiating chest pain is along the left lower sternal border.


Grade 4 Intraoperative Cardiac Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Larynx Obstruction and Stenosis, CTCAE


Childhood Malignant Solid Neoplasm

A malignant solid neoplasm that occurs during childhood.


Suicide Attempt, CTCAE

A disorder characterized by self-inflicted harm in an attempt to end one's own life.


Grade 4 Renal Calculi, CTCAE

Life-threatening consequences; urgent invasive intervention indicated


Infant Acute Undifferentiated Leukemia

An acute undifferentiated leukemia that occurs in infancy.


Grade 1 Prolapse of Gastrointestinal Stoma, CTCAE


Grade 5 Tracheitis, CTCAE

Death


Acute gastritis

Acute inflammation of the stomach.


Periodontal Disease, CTCAE

A disorder in the gingival tissue around the teeth.


Stage IIIA Ampulla of Vater Cancer AJCC v8

Stage IIIA includes: (T1a, N1, M0); (T1b, N1, M0); (T2, N1, M0); (T3a, N1, M0); (T3b, N1, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N1: Metastasis to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Argentaffinoma

A carcinoid tumor that shows atypical characteristics and has borderline malignant potential.


Zonular dehiscence

Rupture of the fibrous strands connecting the ciliary body and the crystalline lens of the eye.


Closed dislocation

A dislocation not complicated by an external wound


Grade 1 Tremor, CTCAE

Mild symptoms


Sickle Beta 0 Thalassemia

A form of sickle cell thalassemia characterized by the absence of hemoglobin A. Patients usually have severe anemia identical to that seen in sickle cell disease.


Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


Substance-induced sleep disorder

A sleep disorder (insomnia, hypersomnia, or parasomnia) for which there is strong evidence that the disorder is etiologically linked to the direct physiological effects of a substance (i.e., a drug of abuse, a medication, or toxin exposure).


Unresectable Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma that is not amenable to surgical resection.


Grade 5 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Infant Acute Lymphoblastic Leukemia without MLL Gene Rearrangement

An acute lymphoblastic leukemia without rearrangement of the MLL (KMT2A) gene that occurs in infancy.


Grade 4 Pneumonitis and Pulmonary Infiltrates, CTCAE


Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malposition of uterus

Orientation of the uterus in an unusual anatomic location or position.


Grade 3 Bronchopulmonary Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Refractory acute myeloid leukemia

Acute myeloid leukemia that does not respond to treatment.


Grade 1 Ureter Stricture or Stenosis, CTCAE


Grade 2 Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


Facial Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the face.


Stage III Fallopian Tube Cancer AJCC v8

Stage III includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0; IIIB: T3b, N0/N1, M0; IIIC: T3c, N0/N1, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Type II Total Anomalous Pulmonary Venous Return

Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the coronary sinus.


Grade 5 Other Sexual Reproductive Function, CTCAE


Grade 5 Gallbladder Necrosis, CTCAE

Death


Hepatocyte Nuclear Factor 4-Alpha Hyperinsulinism

Hyperinsulinism due to mutation(s) in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4-alpha. This condition may progress to diabetes later in life.


Grade 1 Paresthesia, CTCAE

Mild symptoms


Lateral developmental cyst of jaw

A developmental odontogenic cyst lined by non-keratinized epithelium, occurring on the lateral aspect or between the roots of erupted teeth. (WHO 2017)


Grade 4 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cystine urolithiasis

Urolithiasis in which the composition of the stones is predominantly cystine.


Renal Pelvis and Ureter Cancer by AJCC v8 Stage

A term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to renal pelvis and ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. It does not apply to renal cell carcinomas (are staged according to the classification for kidney), renal medullary carcinomas (are staged according to the classification for kidney), collecting duct carcinomas (are staged according to the classification for kidney),  lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and mesenchymal tumors (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs). (from AJCC 8th Ed.)


Megacystis - Megaureter

A condition characterized by a large capacity, thin-walled bladder and megaureter(s).


Grade 1 Larynx Obstruction and Stenosis, CTCAE


Grade 3 Vaginal Stenosis and Length, CTCAE


Grade 3 Papulopustular Rash, CTCAE

Papules and/or pustules covering >30% BSA with moderate or severe symptoms; limiting self-care ADL; IV antibiotics indicated


Condyloma Acuminatum with Dysplasia

Condyloma acuminatum that is associated with the presence of dysplastic epithelial changes.


Adenoma, Trabecular

A benign epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern.


Recurrent Adult Brain Neoplasm

The reemergence of brain neoplasm in adulthood after a period of remission.


Grade 4 Hepatitis Viral, CTCAE

Life-threatening consequences; severe decompensated liver function (e.g., coagulopathy, encephalopathy, coma)


Stage 0is Urethral Cancer AJCC v8

Stage 0is includes: Tis, N0, M0. Tis: For male penile urethra and female urethra: Carcinoma in situ. For prostatic urethra: Carcinoma in situ involving the prostatic urethra or periurethral or prostatic ducts without stromal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Stage I Ureter Cancer AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Gingival Pain, CTCAE

Severe pain; inability to aliment orally


Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Retinopathy of Prematurity, AE

An adverse event in a newborn characterized by bilateral retinal detachment and blindness.


Adenocarcinoma in villous adenoma

A non-invasive or invasive adenocarcinoma arising from a villous adenoma.


Advanced Anal Canal Squamous Cell Carcinoma

Anal canal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IB Osteosarcoma AJCC v7

Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


FIGO Stage IIIA Gestational Trophoblastic Tumor


Grade 4 Neonatal Respiratory Distress Syndrome, AE

A respiratory distress adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; requiring urgent care change (e.g. urgent intubation).


Grade 4 Hip Fracture, CTCAE

Life-threatening consequences; symptoms associated with neurovascular compromise


Grade 4 Hypothyroidism, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Non-Cardiac Chest Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 2 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acquired Cataract

Cataract that results from the aging process, an injury, or as a manifestation of a systemic disorder.


Oropharyngeal Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the oropharynx.


Stage IIIC1 Cervical Cancer FIGO 2018

Cervical carcinoma with pelvic lymph node metastasis only. (FIGO 2018)


Recurrent Small Cell Neuroendocrine Carcinoma

The reemergence of small cell neuroendocrine carcinoma after a period of remission.


Grade 1 Gamma-Glutamyl Transpeptidase, CTCAE


Stage IIA Gastric Cancer AJCC v7

Stage IIA includes: (T3, N0, M0); (T2, N1, M0); (T1, N2, M0). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 3 Injection Site Reaction or Extravasation Changes, CTCAE


Grade 2 Flashing Lights, CTCAE

Limiting instrumental ADL


Death Neonatal, CTCAE

Newborn death occurring during the first 28 days after birth.


Grade 1 Vaginal Dryness, CTCAE

Mild vaginal dryness not interfering with sexual function


Locally Advanced Adenoid Cystic Carcinoma

Adenoid cystic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Ampulla of Vater Hepatoid Adenocarcinoma

A very rare adenocarcinoma that arises from the ampulla of Vater.  It is usually of the intestinal type and is characterized by the presence of malignant polygonal cells with abundant eosinophilic cytoplasm resembling hepatocytes.


Grade 3 Rectal Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Pharyngeal Mucositis, CTCAE

A disorder characterized by ulceration or inflammation involving the mucous membrane of the pharynx.


Stage IA Bone Sarcoma AJCC v7

Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 3 Weight Loss, CTCAE

>=20% from baseline; tube feeding or TPN indicated


Locally Advanced Fallopian Tube Carcinoma

Fallopian tube carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Small Intestinal Perforation, CTCAE 5.0

A disorder characterized by a rupture in the small intestine wall.


Bladder Endometrioid Adenocarcinoma

A rare bladder adenocarcinoma with the histologic characteristics of endometrioid adenocarcinoma of the endometrium.


Lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Metastatic Neuroendocrine Neoplasm

A neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Appendix Tubular Carcinoid

A neuroendocrine tumor that arises from the appendix.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


Grade 2 Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Merkel Cell Carcinoma by AJCC v8 Pathologic Stage

A term that refers to the pathologic staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


Grade 3 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Small Intestinal Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Uterine Anastomotic Leak, CTCAE

Death


Grade 5 Carbon Monoxide Diffusion Capacity, CTCAE


Smoldering Systemic Mastocytosis

Slowly progressive systemic mastocytosis with uncertain prognosis. It is characterized by organomegaly and absence of aggressive disease.


Fibrinogen Decreased

A laboratory test result which indicates decreased levels of fibrinogen in a biological specimen.


Larynx Edema, CTCAE

Laryngeal edema resulting from a known treatment.


Obesity, CTCAE

A disorder characterized by having a high amount of body fat.


Grade 4 Platelet Count Decreased, CTCAE

<25,000/mm3; <25.0 x 10e9/L


Fibrolipoma

A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue.


Stage IIA Testicular Cancer AJCC v8

Stage IIA includes: (Any pT/TX, N1, M0, S0); (Any pT/TX, N1, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Adult Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for adult Hodgkin lymphoma based on the Ann Arbor classification criteria.


Grade 2 Localized Edema, CTCAE

Moderate localized edema and intervention indicated; limiting instrumental ADL


Stage IVA Cervical Cancer AJCC v9

Stage IVA includes: T4, Any N, M0. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 1 Peripheral Sensory Neuropathy, CTCAE

Asymptomatic


Prostate Adenocarcinoma with Neuroendocrine Differentiation

An invasive prostate adenocarcinoma characterized by the presence of malignant cells that exhibit neuroendocrine differentiation.


Psychological Dependence

A behavioral pattern characterized by a craving for the mood-altering effects of a drug and an overwhelming preoccupation with obtaining and using the drug.


Grade 3 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Pleura Intra-Operative Injury, CTCAE


Body Fluid Leakage

The loss of any normal body fluid into the surrounding tissue or body cavity.


Grade 1 Lethargy, CTCAE

Mild symptoms; reduced alertness and awareness


Grade 1 Haptoglobin Decreased, CTCAE

<LLN


Congenital postural scoliosis

Abnormal sideways curvature of the spine that is present at birth.


Grade 4 Seizure, CTCAE

Life-threatening consequences; prolonged repetitive seizures


Grade 5 Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Bronchopulmonary Hemorrhage, CTCAE

A disorder characterized by bleeding from the bronchial wall and/or lung parenchyma.


Grade 3 Pain of Skin, CTCAE

Severe pain; limiting self care ADL


Eye Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the eye.


Grade 3 Other Growth and Development, CTCAE


Grade 1 Scrotal Infection, CTCAE

Localized, local intervention indicated


Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intestinal Stoma Prolapse

An intestinal stoma complication characterized by protrusion of the intestine above the abdominal surface.


Cellular Blue Nevus

A blue nevus characterized by a multinodular cellular infiltrate with a dumb-bell architecture occupying the reticular dermis. The cellular infiltrate often extends into the subcutaneous tissue. The cellular infiltrate is composed of spindle-shaped melanocytes with pale cytoplasm alternating with bundles of pigmented spindle-shaped melanocytes. In occasional cases an increased mitotic activity, focal necrosis, and nuclear pleomorphism may be seen. Such cases with atypical features may have an uncertain malignant potential.


Elevated CA19-9

A laboratory test result indicating the presence of an increased level of the tumor-associated antigen (TAA) CA19-9 in a biological sample.


Grade 3 Neonatal Culture Positive Sepsis, AE

An adverse event in a newborn characterized by a positive blood culture positive with severe signs; supportive treatment escalated or initiated.


Grade 3 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Carcinoma in the Peritoneum

A carcinoma that has spread to the peritoneum from an adjacent or distal anatomic site.


Laryngitis, CTCAE

A disorder characterized by an inflammatory process involving the larynx.


Grade 3 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Clinical Stage IV Retinoblastoma AJCC v8

Stage IV includes: Any cT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Stage I Renal Pelvis and Ureter Cancer AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent Endometrial Transitional Cell Carcinoma

The reemergence of endometrial transitional cell carcinoma after a period of remission.


Refractory Low Grade Glioma

Low grade glioma that is resistant to treatment.


Oxyntic Gland Adenoma

A benign epithelial neoplasm composed of columnar cells with differentiation to chief cells, parietal cells, or both, with a high rate of progression to adenocarcinoma (submucosal invasion). (WHO 2019)


Adult Non-T Non-B Acute Lymphoblastic Leukemia

Non-T non-B acute lymphoblastic leukemia that occurs during adulthood.


Stage IIB Digestive System Neuroendocrine Tumor AJCC v7

Stage IIB includes: T3, N0, M0.  T3: Stomach: tumor penetrates subserosa; jejunum/ileum: tumor invades through the muscularis propria into subserosal tissue without penetration of overlying serosa or invades into non-peritonealized tissues; ampulla/duodenum: tumor invades pancreas or retroperitoneum or into non-peritonealized tissues; colon or rectum: tumor invades through the muscularis propria into the subserosa, or into non-peritonealized pericolic or perirectal tissues. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Non-Obstructed Non-Refluxing Megaureter

A megaureter in which there is no obstruction at the ureterovesical junction and no vesicoureteral reflux.


Hodgkin's disease nodular sclerosis stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Grade 2 Joint Infection, CTCAE

Localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral); needle aspiration indicated (single or multiple)


Grade 2 White Blood Cell Decreased, CTCAE

<3000-2000/mm3; <3.0-2.0 x 10e9/L


Endometrial Endometrioid Adenocarcinoma with an Undifferentiated Carcinomatous Component

A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with undifferentiated malignant cells.


Stage III Gastric Neuroendocrine Tumor AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Suicidal Ideation, CTCAE

Specific plan to commit suicide without serious intent to die which may not require hospitalization


Lugano Classification Stage I Childhood Hodgkin Lymphoma AJCC v8

Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Creatinine Increased, CTCAE

>1.5-3.0 x baseline; >1.5-3.0 x ULN


Stage IB2 Cervical Cancer

Stage IB2 includes: T1b2, N0, M0.  T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


High Grade Esophageal Glandular Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal glandular epithelium.


Grade 1 Urticaria, CTCAE

Urticarial lesions covering <10% BSA; topical intervention indicated


Grade 4 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Neonatal Culture Negative Sepsis, AE

An adverse event in a newborn characterized by suspected sepsis with severe signs (e.g. fever, grunting); supportive treatment escalated or initiated.


Grade 4 Lower Gastrointestinal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Mediastinum Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 1 Ear Pain, CTCAE

Mild pain


Passive-Aggressive Personality Disorder

A disorder characterized by a pattern of indirect expression of hostility, including negativistic attitudes and passive resistance to demands for adequate performance in social and occupational situations.


Grade 5 Hepatitis B Reactivation, CTCAE

Death


Grade 4 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pneumonitis, CTCAE

Severe symptoms; limiting self care ADL; oxygen indicated


Grade 1 Cecal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 1 Investigations - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 3 Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


Adverse Event Attributed to Commercial Product

An indication that an adverse event is causally related to the use of a commercially available product.


Refractory Sarcoma

A sarcoma that does not respond to treatment.


Esophageal mucositis

An inflammatory process affecting the mucous membrane of the esophagus.


Transferase Deficiency Galactosemia

A disorder characterized by the body's inability to metabolize galactose. This type of galactosemia is caused by germline mutations in the GALT gene which leads to the inhibition in the activity of the enzyme galactose-1-phosphate uridyl transferase.


Hip Fracture, CTCAE

A finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken.


Radiating Chest Pain in Back

The location of the radiating chest pain is in the back.


BCOR ITD Sarcoma

A group of rare primitive round cell sarcomas characterized by the presence of BCOR internal tandem duplication. This genetic alteration has been described in infantile undifferentiated round cell sarcomas and primitive myxoid mesenchymal tumors of infancy.


Refractory Langerhans Cell Histiocytosis

Langerhans cell histiocytosis that does not respond to treatment.


Mast Cell Leukemia Associated with Another Hematological Neoplasm

Mast cell leukemia associated with another clonal non-mast cell hematologic neoplasm (e.g., myelodysplastic syndrome, chronic myeloproliferative disorder, acute myeloid leukemia, and lymphoma).


Grade 1 Bladder Stricture or Stenosis, CTCAE


Extrahepatic bile duct cancer stage I

Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0).  T1: Tumor confined to the bile duct histologically.  T2: Tumor invades beyond the wall of the bile duct.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IIB Prostate Cancer AJCC v8

Stage IIB includes: T1-2, N0, M0, PSA less than 20, Grade Group 2. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. (AJCC 8th ed.)


Ocular Graft Versus Host Disease

Graft versus host disease occurring in the eye.


Liver Neuroendocrine Neoplasm

An extremely rare neoplasm with neuroendocrine differentiation that arises from the liver. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Stage IB Uterine Corpus Cancer AJCC v7

Stage IB includes: T1b, N0, M0.  T1b: Tumor invades one-half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Pancreatobiliary Carcinoma

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater.


Refractory Acute Bilineal Leukemia

Acute bilineal leukemia that is resistant to treatment.


Grade 3 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Endometrial Carcinoma

Endometrial carcinoma that is resistant to treatment


Grade 5 Cranial Nerve X Neuropathy, CTCAE


Grade 2 Azoospermia, CTCAE

Absence of sperm in ejaculate


Grade 2 Dental Caries, CTCAE

Dental caries involving the root


Grade 1 Salivary Gland Intra-Operative Injury, CTCAE


Disorder by Site

A term that refers to the classification of a disorder according to the anatomic site that is involved in the pathologic process.


Grade 1 Prostate Intra-Operative Injury, CTCAE


Grade 3 Urinary Retention, CTCAE

Elective invasive intervention indicated; substantial loss of affected kidney function or mass


Jejunal fistula

An abnormal communication between the jejunum and another organ or cavity.


Grade 1 Stoma Pulmonary Hemorrhage, CTCAE


Malignant Lymphoma Follicular, Large Noncleaved Cell Type


Symmetric Chest Appearance

Inspection of the region of the anterior surface of the chest and epigastrium reveals an approximate correspondence of form and constituent configuration on opposite sides of a vertical central dividing line.


Esophageal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Postnasal Drip, CTCAE

A disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing.


Childhood Fibrillary Astrocytoma

A fibrillary astrocytoma that occurs during childhood.


Grade 1 Vagina Intra-Operative Injury, CTCAE


Grade 1 Fecal Incontinence, CTCAE

Occasional use of pads required


Grade 5 Stomach Stricture or Stenosis, CTCAE


Cervical Florid Reactive Lymphoid Hyperplasia

A dense, superficial benign lymphoid cell proliferation in the cervix. It almost always occurs in premenopausal women. It is composed of a mixture of large and small lymphocytes including immunoblasts. Plasma cells and neutrophils are also present. Immunohistochemical studies reveal a mixture of B and T lymphocytes, and polytypic plasma cells.


Metastatic malignant neoplasm to ureter

A malignant neoplasm that has spread to the ureter from another anatomic site.


Lugano Classification Stage IE Hodgkin Lymphoma AJCC v8

Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Resectable Dedifferentiated Liposarcoma

Dedifferentiated liposarcoma that is amenable to surgical resection.


Grade 3 Gastrointestinal Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Dysphagia, CTCAE

Symptomatic, able to eat regular diet


Grade 1 Small Intestinal Mucositis, CTCAE

Asymptomatic or mild symptoms; intervention not indicated


Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Refractory Fallopian Tube Carcinoma

Fallopian tube carcinoma that is resistant to treatment.


Grade 2 Neonatal Epileptic Seizure, AE

An adverse event in a newborn characterized by electroencephalogram (EEG)-proven seizures that are controlled with one anti-seizure drug (no recurrence within three days after treatment).


Venous Thrombosis Related to Vascular Access Complication

The formation of a thrombus in the vein as a direct result of an activity associated with vascular access.


Adult Epithelioid Hemangioendothelioma

An epithelioid hemangioendothelioma that occurs during adulthood.


Radial scar

A benign breast lesion characterized by the presence of fibrosis with stellate appearance in the parenchyma.  The lesions are often multiple and bilateral.  Grossly, the lesions are irregular and firm and resemble carcinoma.  Microscopically, the stellate lesions are composed of dense, hyalinized collagen.  Entrapped in the collagen are tubules.  There is no evidence of cytologic atypia.


Non-Encapsulated Neoplasm

A neoplasm that is non-capsulated.


Tracheal Hemorrhage, CTCAE

A disorder characterized by bleeding from the trachea.


Cranial Nerve Injuries

Injury to, or disease of, the cranial nerve


Grade 3 Insomnia, CTCAE

Severe difficulty in falling asleep, staying asleep or waking up early


Grade 4 Spermatic Cord Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Grade 1 Blood Bilirubin Increased, CTCAE

>ULN-1.5 x ULN if baseline was normal; > 1.0-1.5 x baseline if baseline was abnormal


Human Papillomavirus-Related Vaginal Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the vagina and is caused by human papillomavirus infection.


Adnexal mass

An abnormal growth in the ovary, fallopian tube, or surrounding connective tissue.


Grade 3 Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Periodontal Disease, CTCAE

Spontaneous bleeding; severe bone loss with or without tooth loss; osteonecrosis of maxilla or mandible


Grade 4 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Grade 2 Urticaria, CTCAE

Urticarial lesions covering 10-30% BSA; oral intervention indicated


Non-ischemic Stroke

Any stroke that is not related to an obstructed blood vessel.


Delusional disorder, grandiose type

A subtype of delusional disorder characterized by the central delusional theme that the individual has special worth, power, knowledge, or a special relationship to a famous person or deity.


Grade 4 Ileum Stricture or Stenosis, CTCAE


Recurrent Childhood Anaplastic Astrocytoma

The reemergence of anaplastic astrocytoma in childhood after a period of remission.


Miniature Adult Form of AHC

An autosomal recessive or sporadic form of adrenal hypoplasia congenita frequently associated with central nervous system anomalies including anencephaly and pituitary defects. Histologically the adrenal gland is distinguished by the absence of fetal adrenal cortex and the presence of a small amount of normal, permanent adult adrenal cortex.


Congenital Coronary Artery Abnormality

A congenital condition referring to defects of the course and structure of the coronary arteries.


Arterial Injury, CTCAE

A finding of damage to an artery.


Dyspepsia, CTCAE

A disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting.


Grade 4 Rectum Stricture or Stenosis, CTCAE


Benign Adult Cerebellar Neoplasm

A benign neoplasm of the cerebellum occurring in adults.


Esophagitis, CTCAE

A disorder characterized by inflammation of the esophageal wall.


Arachnoiditis and Meningismus and Radiculitis, CTCAE


Endometrial Endometrioid Adenocarcinoma with Small Nonvillous Papillae


Stage IB Bone Cancer AJCC v8

Stage IB includes: (T2, N0, M0, G1 or GX); (T3, N0, M0, G1 or GX). T2: Tumor measuring more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


Grade 2 Urinary Urgency, CTCAE

Limiting instrumental ADL; medical management indicated


Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic basal cell carcinoma

A carcinoma that arises from the basal cells and has metastasized to another anatomic site.


Stage III Cervical Cancer AJCC v9

Stage III includes: T3, N0, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Uterine Perforation, CTCAE

A disorder characterized by a rupture in the uterine wall.


Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Uterus Stricture or Stenosis, CTCAE


Grade 1 Spermatic Cord Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Agenesis

A congenital abnormality resulting in the absence of an anatomical structure.


Grade 5 Iron Overload, CTCAE

Death


Grade 3 Hypoxic Ischemic Encephalopathy, AE

An adverse event in a newborn characterized by moderate clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event; meeting criteria for therapeutic hypothermia.


Stage I Cervical Cancer FIGO 2018

The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2018)


Grade 2 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Salivary Duct Inflammation, CTCAE

Slightly thickened saliva; slightly altered taste (e.g., metallic)


Grade II Glandular Intraepithelial Neoplasia


Grade 3 Associated with the Teeth, CTCAE


An epithelioid hemangioendothelioma that occurs during childhood.


Grade 1 Dysuria, CTCAE

Present


Locally Advanced Osteosarcoma

Osteosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Neonatal Rash, AE

An adverse event in a newborn characterized by diffuse rash and vesicles or limited number of bullae or superficial ulcerations of mucous membranes limited to one site.


Grade 4 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IV Extrahepatic Bile Duct Cancer

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th ed.)


Grade 2 Erectile Dysfunction, CTCAE

Decrease in erectile function (frequency/rigidity of erections), erectile intervention indicated, (e.g., medication or mechanical devices such as penile pump)


Methotrexate-Associated Lymphoma

A non-Hodgkin or Hodgkin lymphoma that develops in patients who are immunosuppressed with methotrexate.


Transitory tachypnea of newborn

A respiratory disorder characterized by higher than normal respiratory rates among premature and cesarean section delivered neonates whose lungs have not fully matured. The cause is often excess fluid in the lungs, and resolution is aided by supplemental oxygen and sometimes, antibiotics.


Grade 4 Neonatal Rash, AE

An adverse event in a newborn characterized by extensive or generalized bullous lesions or ulceration of mucous membranes involving two or more distinct mucosal sites or Stevens-Johnson syndrome or toxic epidermal necrosis.


Grade 1 Nasal Cavity Intra-Operative Injury, CTCAE


Systemic lupus erythematosus, childhood onset

Systemic lupus erythematosus (SLE) diagnosed in individuals under the age of eighteen. Children frequently have multi-organ involvement and acute disease onset. Symptoms include fever, arthritis, skin lesions, anemia, and fatigue.


Grade 5 Other Constitutional Symptoms, CTCAE


Benign neoplasm of female breast

A non-metastasizing neoplasm that arises from the breast parenchyma in females.


Grade 3 Neuralgia, CTCAE

Severe pain; limiting self care ADL


Eye Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Grade 5 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Intraoperative Musculoskeletal Injury, CTCAE

Partial resection of injured organ/structure indicated


Grade 4 Menorrhagia, CTCAE

Life-threatening consequences; urgent intervention indicated


Posterior Fossa Neoplasm

A neoplasm that arises from the posterior cranial fossa. Examples include meningiomas and medulloblastomas.


Grade 4 Necrotizing Enterocolitis, AE

A necrotizing enterocolitis adverse event in a newborn characterized by bowel perforation (pneumoperitoneum)(modified Bell stage IIIB); shock, disseminated intravascular coagulation (DIC), combined respiratory and metabolic acidosis (modified Bell stage IIIA); urgent major care change indicated.


Urine Discoloration, CTCAE

A disorder characterized by a change in the color of the urine.


Grade 1 Tendon Intra-Operative Injury, CTCAE


Recurrent Atypical Meningioma

The reemergence of atypical meningioma after a period of remission.


Grade 1 Oral Cavity NOS Intra-Operative Injury, CTCAE


Grade 1 Anal Pain, CTCAE

Mild pain


Transient Myocardial Dysfunction of Newborn

A condition in a newborn characterized by a temporary decrease in right ventricular and/or left ventricular output.


Hutch diverticulum

A congenital out pouching of the bladder involving the ureteral hiatus.


Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Pulmonary Hypertension, CTCAE

Life-threatening airway consequences; urgent intervention indicated (e.g., tracheotomy or intubation)


Grade 3 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Radiculitis, CTCAE

Moderate symptoms; medical intervention indicated; limiting instrumental ADL


Spermatic Cord Stricture or Stenosis, CTCAE


Obesity-Associated Insulin Resistance

Insulin resistance associated with obesity, which may be attributed in part to impaired insulin signaling in target tissues, or impaired insulin-stimulated glucose transport due to reduced expression of the glucose transporter protein 4.


Clinical Stage IIC Cutaneous Melanoma AJCC v8

Stage IIC includes: T4b, N0, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Lymphoma, EBV-associated

Lymphoma that is caused by Epstein-Barr virus infection.


Grade 2 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage I Anal Canal Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Increased Time To Peak Drug Blood Concentration

Increased period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.


Cutaneous Malignant Melanoma 2

An autosomal dominant genetic disorder caused by mutations in the CDKN2A gene, encoding cyclin-dependent kinase inhibitor 2A. The condition is characterized by cutaneous malignant melanoma associated with this genetic alteration.


Stage IVA Appendix Carcinoma AJCC v8

Stage IVA includes: (Any T, N0, M1a); (Any T, Any N, M1b, G1). N0: No regional lymph node metastasis. M1a: Intraperitoneal acellular mucin, without identifiable tumor cells in the disseminated peritoneal mucinous deposits. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. G1: Well differentiated. (AJCC 8th ed.)


Grade 4 Vas Deferens Stricture or Stenosis, CTCAE


Lipase Increased, CTCAE

A finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen.


Chest Pain in Lower Sternum

The location of the chest pain is in the lower portion of the sternum.


Follicle Stimulating Hormone Receptor Deficiency

Reduced or absent function of the receptor for follicle stimulating hormone associated with a mutation in the FSHR gene.


Grade 3 Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


Grade 4 Lens Intra-Operative Injury, CTCAE


Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Pharynx Intra-Operative Injury, CTCAE


Vaginal Obstruction, CTCAE 5.0

A disorder characterized by blockage of vaginal canal.


Adult L2 Acute Lymphoblastic Leukemia

L2 acute lymphoblastic leukemia that occurs during adulthood.


Central Nervous System SMARCB1/INI1-Deficient Tumor

A group of SMARCB1/INI1 deficient tumors that arise from the central nervous system. It includes highly aggressive and slow-growing tumors.


Grade 4 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Intraoperative Respiratory Injury, CTCAE

Primary repair of injured organ/structure indicated


Grade 2 Breast Nipple and Areolar Deformity, CTCAE


Grade 4 Thrombotic Thrombocytopenic Purpura, CTCAE

Life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure)


Grade 5 Thrombosis or Thrombus or Embolism, CTCAE


Grade 5 Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Clinical Stage 0 Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Muscle Intra-Operative Injury, CTCAE


Grade 4 Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malignant Lymphoma by Cell Type (Working Formulation)


Old Burn Scar-Related Cutaneous Melanoma

A cutaneous melanoma that arises in an old burn scar tissue.


Stage I Intermediate Grade Adult Non-Hodgkin's Lymphoma


Vertigo, CTCAE

A disorder characterized by a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo).


Grade 3 Gamma-Glutamyl Transpeptidase, CTCAE


Grade 5 Peritoneal Infection, CTCAE

Death


Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Reactive Vascular Proliferation

A non-neoplastic proliferation of vessels in reaction to a process.


Hepatic Vein Intra-Operative Injury, CTCAE


Recurrent Platinum-Resistant Fallopian Tube Carcinoma

The reemergence of platinum-resistant fallopian tube carcinoma after a period of remission.


Grade 3 Hiccups, CTCAE

Severe symptoms; interfering with sleep; limiting self care ADL


Stage IV Vulvar Cancer AJCC v6

Stage IV includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0); IVB (Any T, Any N, M1).  T4: Tumor invades any of the following: upper urethra bladder mucosa, rectal mucosa, or is fixed to the pubic bone.  N2: Bilateral regional lymph node metastasis.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 6th ed.)


Bladder Flat Urothelial Carcinoma

An in situ or invasive urothelial carcinoma that arises from the bladder wall and does not grow toward the hollow part of the bladder.


Grade 2 Tracheal Obstruction, CTCAE

Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


Grade 2 Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intracranial Myeloid Sarcoma

A myeloid sarcoma that affects the meninges or the cerebral hemispheres.


Grade 2 Feeding Intolerance, AE

An adverse event in a newborn characterized by moderate feeding intolerance; resulting in minor discomfort or alteration of drinking behavior; minor care changes indicated (e.g. feeds withheld).


Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Esophagus Stricture or Stenosis, CTCAE


Grade 4 Other Hemorrhage and Bleeding, CTCAE


High Grade Cervical Intraepithelial Neoplasia

Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes.


Grade 2 Akathisia, CTCAE

Moderate restlessness or increased motor activity; limiting instrumental ADL


Grade 2 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IIIA Vulvar Cancer AJCC v8

Stage IIIA includes: T1-T2, N1, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 3 Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Fibrosarcoma non-metastatic

Fibrosarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Anorectal infection

An infectious process affecting the anal area and the rectum.


Grade 5 Cholecystitis, CTCAE

Death


Grade 4 Uterus Intra-Operative Injury, CTCAE


Unspecified idiopathic peripheral neuropathy

Neuropathy, the cause of which is not known.


Spotty/Minimal Hemorrhage

Small (<3mm) foci of hemorrhage within the tumor.


Grade 4 Confusion, CTCAE

Life-threatening consequences; urgent intervention indicated


Eosinophilia, CTCAE

A disorder characterized by laboratory test results that indicate an increased number of eosinophils in the blood.


Oligometastatic Malignant Solid Neoplasm

A malignant solid neoplasm that has metastasized to a limited number of sites— existing in a state intermediate between localized disease and widespread metastatic disease.


Persistent Oligoarticular Juvenile Idiopathic Arthritis

Oligoarticular juvenile idiopathic arthritis that never involves more than four separate joints after six months.


Locally Advanced Prostate Carcinoma

A prostatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Cervical Neuroendocrine Neoplasm

A neuroendocrine neoplasm that arises from the cervix. This category includes neuroendocrine tumor grade 1, neuroendocrine tumor grade 2, and neuroendocrine carcinoma (small cell and large cell neuroendocrine carcinoma).


Induration or Fibrosis of the Skin and Subcutaneous Tissue, CTCAE


Grade 2 Ascites, CTCAE

Symptomatic; medical intervention indicated


Grade 1 Breast Intra-Operative Injury, CTCAE


Grade 4 Upper Extremity Artery Intra-Operative Injury, CTCAE


Pleural Effusion, CTCAE

A disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort.


Stage IA Uterine Corpus Cancer AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Uterine corpus carcinoma or carcinosarcoma with tumor limited to the endometrium or invading less than half the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Rectal Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the intestinal contents in the rectum.


Grade 3 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 5 Myasthenia Gravis, CTCAE

Death


Pediatric Viral Infection

A viral infection that occurs during infancy, childhood or adolescence.


Grade 4 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Vas Deferens Stricture or Stenosis, CTCAE


Immune Checkpoint Inhibitor-related Myocarditis

Myocarditis associated with the therapeutic use of an immune checkpoint inhibitor.


Meningeal Melanocytoma of Intermediate Grade

A circumscribed meningeal melanocytic neoplasm with bland histological features and increased mitotic activity or invasion of the central nervous system.


Pressing Pain

A sensation of discomfort or distress from excess weight or pressure on a specific anatomical location.


Fetus Small for Gestational Age with Abdominal Circumference Less than Tenth Percentile

A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and whose abdominal circumference falls below the tenth percentile.


Grade 2 Otitis Media, CTCAE

Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Dusky Mucosa

A finding indicating the presence of dark discoloration on the mucosal surface. It is associated with tissue necrosis.


Refractory Abdominal Neuroendocrine Neoplasm

An abdominal neuroendocrine neoplasm that does not respond to treatment.


Grade 4 Arteritis Infective, CTCAE

Life-threatening consequences; urgent intervention indicated


Nasal Cavity Intra-Operative Injury, CTCAE


Grade 3 Uterine Pain, CTCAE

Severe pain; limiting self care ADL


Grade 3 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Vaginal Large Cell Neuroendocrine Carcinoma

A rare, aggressive neuroendocrine carcinoma that arises from the vagina and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli.


Childhood Diffuse Large Cell Lymphoma

A diffuse large cell lymphoma occurring in children.


Recurrent Epstein-Barr Virus-Related Lymphoproliferative Disease with Primary Immunodeficiency

The reemergence of Epstein-Barr virus-associated lymphoproliferative disease with primary immunodeficiency after a period of remission.


Retinoblastoma by AJCC v8 Pathologic Stage

A term that refers to the pathologic staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition.


Grade 4 Testes Stricture or Stenosis, CTCAE


Grade 5 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Diffuse Midline Glioma with EZHIP Overexpression

A diffuse midline glioma, H3 K27-altered, characterized by the presence of EZHIP overexpression.


Lymph Node Follicular Hyperplasia

Hyperplasia of the germinal centers resulting in the enlargement of the lymph node.


Latent Infection

A period in which the infection is present in the host without producing overt symptoms.  (from Online Medical Dictionary)


Grade 3 Cardiac Ischemia or Infarction, CTCAE


Grade 4 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Testicular Sclerosing Sertoli Cell Tumor

A rare testicular Sertoli cell tumor characterized by the presence of neoplastic tubules that are surrounded by a dense fibrotic stroma.


Grade 2 Investigations - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 2 Neonatal Sinus Tachycardia, AE

An adverse event in a newborn characterized by persistent sinus tachycardia; no change in age appropriate behavior; requiring minor care changes (e.g. concomitant medication changed).


Grade 2 Pneumonitis, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Grade 1 Epistaxis, CTCAE

Mild symptoms; intervention not indicated


Grade 3 Thromboembolic Event, CTCAE

Urgent medical intervention indicated (e.g., pulmonary embolism or intracardiac thrombus)


Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Elevated Serum CA-125 Tumor Antigen

A finding indicating elevated concentrations of the tumor antigen CA-125 in a blood serum sample.


Grade 1 Social Circumstances - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 2 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE