SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (sprot)

An NAD-dependent protein deacetylase sirtuin-3, mitochondrial that is encoded in the genome of human.


SARM1_HUMAN NAD(+) hydrolase SARM1 (sprot)

An NAD(+) hydrolase SARM1 that is encoded in the genome of human.


S29A1_RAT Equilibrative nucleoside transporter 1 (sprot)

An equilibrative nucleoside transporter 1 that is encoded in the genome of rat.


KCNA4_RAT Potassium voltage-gated channel subfamily A member 4 (sprot)

A voltage-gated potassium channel alpha subunit KCNA4 that is encoded in the genome of rat.


Niclosamide

An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). Although suggested as a potential treatment for COVID-19 based on its broad antiviral activity, including in vitro activity against coronaviruses, there are no data to support the use of niclosamide in the treatment of COVID-19.

A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.


ACHA7_MOUSE Neuronal acetylcholine receptor subunit alpha-7 (sprot)

A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of mouse.


ACHA9_RAT Neuronal acetylcholine receptor subunit alpha-9 (sprot)

A neuronal acetylcholine receptor subunit alpha-9 that is encoded in the genome of rat.


CRTY_PANAN Lycopene beta-cyclase (sprot)


ACH4_DROME Acetylcholine receptor subunit beta-like 2 (sprot)

A protein that is a translation product of the nAChRbeta2 gene in fruit fly.


ACHA4_CHICK Neuronal acetylcholine receptor subunit alpha-4 (sprot)

A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of chicken.


ACHA4_MOUSE Neuronal acetylcholine receptor subunit alpha-4 (sprot)

A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of mouse.


ACHB3_RAT Neuronal acetylcholine receptor subunit beta-3 (sprot)

A neuronal acetylcholine receptor subunit beta-3 that is encoded in the genome of rat.


ACHA5_RAT Neuronal acetylcholine receptor subunit alpha-5 (sprot)

A protein that is a translation product of the Chrna5 gene in rat.


ACHA_RAT Acetylcholine receptor subunit alpha (sprot)

An acetylcholine receptor subunit alpha that is encoded in the genome of rat.


ACHB_RAT Acetylcholine receptor subunit beta (sprot)

An acetylcholine receptor subunit beta that is encoded in the genome of rat.


ACHA6_RAT Neuronal acetylcholine receptor subunit alpha-6 (sprot)

A neuronal acetylcholine receptor subunit alpha-6 that is encoded in the genome of rat.


ACH10_RAT Neuronal acetylcholine receptor subunit alpha-10 (sprot)

A neuronal acetylcholine receptor subunit alpha-10 that is encoded in the genome of rat.


KCND3_RAT Potassium voltage-gated channel subfamily D member 3 (sprot)

A voltage-gated potassium channel KCND3 that is encoded in the genome of rat.


GLRA3_HUMAN Glycine receptor subunit alpha-3 (sprot)

A glycine receptor subunit alpha-3 that is encoded in the genome of human.


CAC1C_CAVPO Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)


KCNA1_MOUSE Potassium voltage-gated channel subfamily A member 1 (sprot)

A voltage-gated potassium channel subunit KCNA1 that is encoded in the genome of mouse.


KCNA2_RAT Potassium voltage-gated channel subfamily A member 2 (sprot)

A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of rat.


Niflumic acid

An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.


CLCKA_HUMAN Chloride channel protein ClC-Ka (sprot)

A chloride channel protein ClC-Ka that is encoded in the genome of human.


CLCKB_HUMAN Chloride channel protein ClC-Kb (sprot)

A chloride channel protein ClC-Kb that is encoded in the genome of human.


SOX18_MOUSE Transcription factor SOX-18 (sprot)

A transcription factor SOX-18 that is encoded in the genome of mouse.


NTRK2_HUMAN BDNF/NT-3 growth factors receptor (sprot)

A BDNF/NT-3 growth factors receptor that is encoded in the genome of human.


NTRK3_HUMAN NT-3 growth factor receptor (sprot)

An NT-3 growth factor receptor that is encoded in the genome of human.


TAOK1_HUMAN Serine/threonine-protein kinase TAO1 (sprot)

A serine/threonine-protein kinase TAO1 that is encoded in the genome of human.


ILK_HUMAN Integrin-linked protein kinase (sprot)

An integrin-linked protein kinase that is encoded in the genome of human.


S6A19_RAT Sodium-dependent neutral amino acid transporter B(0)AT1 (sprot)

A sodium-dependent neutral amino acid transporter B(0)AT1 that is encoded in the genome of rat.


L8I2E6_9CETA Dipeptidyl peptidase 3 (trembl)


CAC1D_MOUSE Voltage-dependent L-type calcium channel subunit alpha-1D (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1D that is encoded in the genome of mouse.


PNO_CRYPV Pyruvate dehydrogenase [NADP(+)] (sprot)


Q24982_GIAIN Pyruvate:ferredoxin oxidoreductase (trembl)


Q0P8E1_CAMJE Pyruvate-flavodoxin oxidoreductase (trembl)


HPPD_HUMAN 4-hydroxyphenylpyruvate dioxygenase (sprot)

A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of human.


HPPD_PIG 4-hydroxyphenylpyruvate dioxygenase (sprot)

A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of pig.


HPPD_RAT 4-hydroxyphenylpyruvate dioxygenase (sprot)

A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of rat.


PTAFR_CAVPO Platelet-activating factor receptor (sprot)

A mammalian-type platelet-activating factor receptor that is encoded in the genome of guinea pig.


VM1B1_BOTAS Snake venom metalloproteinase BaP1 (sprot)


Nitroxoline

A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.


CATB_HUMAN Cathepsin B (sprot)

A cathepsin B that is encoded in the genome of human.


CGL_HUMAN Cystathionine gamma-lyase (sprot)

A cystathionine gamma-lyase that is encoded in the genome of human.


Nomifensine

An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)

An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.


HBB_HUMAN Hemoglobin subunit beta (sprot)

A hemoglobin subunit beta that is encoded in the genome of human.


ADA1B_MESAU Alpha-1B adrenergic receptor (sprot)

A protein that is a translation product of the ADRA1B gene in Mesocricetus auratus.


ADA2C_MOUSE Alpha-2C adrenergic receptor (sprot)

An alpha-2C adrenergic receptor that is encoded in the genome of mouse.


ADA2A_MOUSE Alpha-2A adrenergic receptor (sprot)

An alpha-2A adrenergic receptor that is encoded in the genome of mouse.


KCJ10_HUMAN ATP-sensitive inward rectifier potassium channel 10 (sprot)

An ATP-sensitive inward rectifier potassium channel 10 that is encoded in the genome of human.


Novobiocin

An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)

A coumarin-derived antibiotic obtained from Streptomyces niveus.


Q7X1P7_STREE DNA topoisomerase (ATP-hydrolyzing) (Fragment) (trembl)


C3SLN2_ECOLX DNA gyrase subunit B (trembl)


GYRA_STAEQ DNA gyrase subunit A (sprot)

A DNA gyrase subunit A that is encoded in the genome of Staphylococcus epidermidis RP62A.


GYRB_STAEQ DNA gyrase subunit B (sprot)

A DNA gyrase subunit B that is encoded in the genome of Staphylococcus epidermidis RP62A.


GYRB_STAAU DNA gyrase subunit B (sprot)

A protein that is a translation product of the gyrB gene in Staphylococcus aureus.


C3SLN3_ECOLX DNA gyrase subunit B (trembl)


PARE_STAAU DNA topoisomerase 4 subunit B (sprot)

A protein that is a translation product of the parE gene in Staphylococcus aureus.


SSR5_MOUSE Somatostatin receptor type 5 (sprot)

A somatostatin receptor type 5 that is encoded in the genome of mouse.


POL_HTL1A Gag-Pro-Pol polyprotein (sprot)


ATP4B_PIG Potassium-transporting ATPase subunit beta (sprot)

A potassium-transporting ATPase subunit beta that is encoded in the genome of pig.


ATP4A_PIG Potassium-transporting ATPase alpha chain 1 (sprot)

A potassium-transporting ATPase alpha chain 1 that is encoded in the genome of pig.


ATP4B_RABIT Potassium-transporting ATPase subunit beta (sprot)


ATP4A_RABIT Potassium-transporting ATPase alpha chain 1 (sprot)


DGLA_HUMAN Diacylglycerol lipase-alpha (sprot)

A diacylglycerol lipase-alpha that is encoded in the genome of human.


DGLB_HUMAN Diacylglycerol lipase-beta (sprot)

A diacylglycerol lipase-beta that is encoded in the genome of human.


ABHGA_HUMAN Phosphatidylserine lipase ABHD16A (sprot)

A phosphatidylserine lipase ABHD16A that is encoded in the genome of human.


ABD12_HUMAN Lysophosphatidylserine lipase ABHD12 (sprot)

A lysophosphatidylserine lipase ABHD12 that is encoded in the genome of human.


PAFA_HUMAN Platelet-activating factor acetylhydrolase (sprot)

A platelet-activating factor acetylhydrolase that is encoded in the genome of human.


LIPP_PIG Pancreatic triacylglycerol lipase (sprot)


ABHD6_HUMAN Monoacylglycerol lipase ABHD6 (sprot)

A monoacylglycerol lipase ABHD6 that is encoded in the genome of human.


DGLA_MOUSE Diacylglycerol lipase-alpha (sprot)

A diacylglycerol lipase-alpha that is encoded in the genome of mouse.


LIPC_HUMAN Hepatic triacylglycerol lipase (sprot)

A hepatic triacylglycerol lipase that is encoded in the genome of human.


LIPG_HUMAN Endothelial lipase (sprot)

An endothelial lipase that is encoded in the genome of human.


LIPP_HUMAN Pancreatic triacylglycerol lipase (sprot)

A pancreatic triacylglycerol lipase that is encoded in the genome of human.


LIPF_HUMAN Gastric triacylglycerol lipase (sprot)

A gastric triacylglycerol lipase that is encoded in the genome of human.


Phenindione

An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)


NRAM_I34A1 Neuraminidase (sprot)

A neuraminidase subtype N1 (Influenza A virus) that is encoded in the genome of the H1N1 strain A/Puerto Rico/8/1934.


NRAM_INBLE Neuraminidase (sprot)

A neuraminidase (Influenza B virus) that is encoded in the genome of strain B/Lee/1940.


Q2LFS1_9INFA Neuraminidase (Fragment) (trembl)


NRAM_I33A0 Neuraminidase (sprot)

A neuraminidase subtype N1 (Influenza A virus) that is encoded in the genome of the H1N1 strain A/Wilson-Smith/1933.


NRAM_I77AB Neuraminidase (sprot)

A neuraminidase subtype N1 (Influenza A virus) that is encoded in the genome of the H1N1 strain A/USSR/90/1977.


NRAM_I63A3 Neuraminidase (sprot)

A neuraminidase subtype N8 (Influenza A virus) that is encoded in the genome of the H3N8 strain strain A/Duck/Ukraine/1/1963.


NRAM_I71A1 Neuraminidase (sprot)

A neuraminidase subtype N2 (Influenza A virus) that is encoded in the genome of the H3N2 strain A/Memphis/1/1971.


UMPS_HUMAN Uridine 5'-monophosphate synthase (sprot)

A uridine 5'-monophosphate synthase that is encoded in the genome of human.


Ouabain

A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.

A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.


Oxametacin

A hydroxamic acid obtained by formal condensation of the carboxy group of indometacin with the amino group of hydroxylamine.


HYES_MOUSE Bifunctional epoxide hydrolase 2 (sprot)

An epoxide hydrolase 2 that is encoded in the genome of mouse.


HYES_RAT Bifunctional epoxide hydrolase 2 (sprot)

An epoxide hydrolase 2 that is encoded in the genome of rat.


Oxatomide

orally active H1-histamine receptor antagonist used to treat chronic urticaria and allergic rhinitis

A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug.


ADA2A_PIG Alpha-2A adrenergic receptor (sprot)


ADA2B_MOUSE Alpha-2B adrenergic receptor (sprot)

An alpha-2B adrenergic receptor that is encoded in the genome of mouse.


Oxyphenbutazone

A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)

A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.


PTGIS_HUMAN Prostacyclin synthase (sprot)

A prostacyclin synthase that is encoded in the genome of human.


Oxyphenonium

A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect.


NEU1_HUMAN Oxytocin-neurophysin 1 (sprot)

An oxytocin-neurophysin 1 that is encoded in the genome of human.


THAS_RAT Thromboxane-A synthase (sprot)

A thromboxane-A synthase that is encoded in the genome of rat.


Palmitoylethanolamide

a cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection; structure

An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid.


GPR55_HUMAN G-protein coupled receptor 55 (sprot)

A G-protein coupled receptor 55 that is encoded in the genome of human.


HPRT_TRYBB Hypoxanthine-guanine phosphoribosyltransferase (sprot)


Q81VW8_BACAN Dihydropteroate synthase (trembl)


HPPK_MYCTO 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (sprot)


PDE10_RAT cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (sprot)

A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A that is encoded in the genome of rat.


PDE1A_BOVIN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (sprot)


PDE1B_BOVIN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (sprot)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B that is encoded in the genome of cow.


PDE1B_RAT Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (sprot)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B that is encoded in the genome of rat.


PDE1C_RAT Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (sprot)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C that is encoded in the genome of rat.


ARBK1_BOVIN Beta-adrenergic receptor kinase 1 (sprot)


Pefloxacin

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.

A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.


TYSY_ECOLI Thymidylate synthase (sprot)

A thymidylate synthase that is encoded in the genome of Escherichia coli K-12.


TYSY_RAT Thymidylate synthase (sprot)

A thymidylate synthase that is encoded in the genome of rat.


E2QDN0_ECOLX Thymidylate synthase (trembl)


PUR2_MOUSE Trifunctional purine biosynthetic protein adenosine-3 (sprot)

A trifunctional purine biosynthetic protein adenosine-3 that is encoded in the genome of mouse.


PUR2_HUMAN Trifunctional purine biosynthetic protein adenosine-3 (sprot)

A trifunctional purine biosynthetic protein adenosine-3 that is encoded in the genome of human.


A1AG1_HUMAN Alpha-1-acid glycoprotein 1 (sprot)

An alpha-1-acid glycoprotein 1 that is encoded in the genome of human.


Penfluridol

One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.


Pentagastrin

A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.


S100B_HUMAN Protein S100-B (sprot)

A protein S100-B that is encoded in the genome of human.


AOC1_HUMAN Amiloride-sensitive amine oxidase [copper-containing] (sprot)

An amiloride-sensitive amine oxidase [copper-containing] that is encoded in the genome of human.


SAT1_HUMAN Diamine acetyltransferase 1 (sprot)

A diamine acetyltransferase 1 that is encoded in the genome of human.


TP4A3_HUMAN Protein tyrosine phosphatase type IVA 3 (sprot)

A protein tyrosine phosphatase type IVA 3 that is encoded in the genome of human.


S100B_RAT Protein S100-B (sprot)

A protein S100-B that is encoded in the genome of rat.


TP4A2_HUMAN Protein tyrosine phosphatase type IVA 2 (sprot)

A protein tyrosine phosphatase type IVA 2 that is encoded in the genome of human.


TP4A1_HUMAN Protein tyrosine phosphatase type IVA 1 (sprot)

A protein tyrosine phosphatase type IVA 1 that is encoded in the genome of human.


Pentolinium

A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.

A dication whose structure comprises a pentane backbone linking two 1-methylpyrrolidinium groups; a nicotinic antagonist used as a ganglionic blocking agent in hypertension.


ADA_BOVIN Adenosine deaminase (sprot)

An adenosine deaminase that is encoded in the genome of cow.


Q86GS5_PLAFA Adenosine deaminase (trembl)


Perhexiline

2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.


CPT2_HUMAN Carnitine O-palmitoyltransferase 2, mitochondrial (sprot)

A carnitine O-palmitoyltransferase 2, mitochondrial that is encoded in the genome of human.


CPT1A_RAT Carnitine O-palmitoyltransferase 1, liver isoform (sprot)

A carnitine O-palmitoyltransferase 1, liver isoform that is encoded in the genome of rat.


Periciazine

A member of the class of  phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.


Phenazocine

An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)


AOC3_HUMAN Membrane primary amine oxidase (sprot)

A membrane primary amine oxidase that is encoded in the genome of human.


Phenformin

A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)

A member of the class of biguanides that is  biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of  lactic acidosis.


PPBI_BOVIN Intestinal-type alkaline phosphatase (sprot)


GP139_HUMAN Probable G-protein coupled receptor 139 (sprot)

A probable G-protein coupled receptor 139 that is encoded in the genome of human.


XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (sprot)

A baculoviral IAP repeat-containing protein 4 that is encoded in the genome of human.


ACES_CHICK Acetylcholinesterase (sprot)

An acetylcholinesterase that is encoded in the genome of chicken.


A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.

A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.


Picrotin

the less toxic component of picrotoxin lacking GABA activity

An organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity.


ACM1_DROME Muscarinic acetylcholine receptor DM1 (sprot)

A muscarinic acetylcholine receptor M3 that is encoded in the genome of fruit fly.


IL2_HUMAN Interleukin-2 (sprot)

An interleukin-2 that is encoded in the genome of human.


PP2BC_HUMAN Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (sprot)

A serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform that is encoded in the genome of human.


FKB1A_RAT Peptidyl-prolyl cis-trans isomerase FKBP1A (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP1A that is encoded in the genome of rat.


UBP1_HUMAN Ubiquitin carboxyl-terminal hydrolase 1 (sprot)

A ubiquitin carboxyl-terminal hydrolase 1 that is encoded in the genome of human.


CAC1H_RAT Voltage-dependent T-type calcium channel subunit alpha-1H (sprot)

A voltage-dependent T-type calcium channel subunit alpha-1H that is encoded in the genome of rat.


PPARG_MOUSE Peroxisome proliferator-activated receptor gamma (sprot)

A peroxisome proliferator-activated receptor gamma that is encoded in the genome of mouse.


PPARG_RAT Peroxisome proliferator-activated receptor gamma (sprot)

A peroxisome proliferator-activated receptor gamma that is encoded in the genome of rat.


CISD1_RAT CDGSH iron-sulfur domain-containing protein 1 (sprot)

A CDGSH iron-sulfur domain-containing protein 1 that is encoded in the genome of rat.


CISD2_HUMAN CDGSH iron-sulfur domain-containing protein 2 (sprot)

A CDGSH iron-sulfur domain-containing protein 2 that is encoded in the genome of human.


GBRB_CAEEL Gamma-aminobutyric acid receptor subunit beta (sprot)

A protein that is a translation product of the gab-1 gene in worm.


TEAD1_HUMAN Transcriptional enhancer factor TEF-1 (sprot)

A transcriptional enhancer factor TEF-1 that is encoded in the genome of human.


TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (sprot)

A transcriptional enhancer factor TEF-4 that is encoded in the genome of human.


TEAD3_HUMAN Transcriptional enhancer factor TEF-5 (sprot)

A transcriptional enhancer factor TEF-5 that is encoded in the genome of human.


Pirmenol

an antiarrhythmic with class Ia activity


Pirprofen

anti-inflammatory agent used in therapy of rheumatoid arthritis; prostaglandin synthetase inhibitor; more potent than indomethacin; structure


Pizotifen

Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.

A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety by a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.


GHSR_RAT Growth hormone secretagogue receptor type 1 (sprot)

A growth hormone secretagogue receptor that is encoded in the genome of rat.


GHSR_HUMAN Growth hormone secretagogue receptor type 1 (sprot)

A growth hormone secretagogue receptor that is encoded in the genome of human.


RAMP2_HUMAN Receptor activity-modifying protein 2 (sprot)

A receptor activity-modifying protein 2 that is encoded in the genome of human.


CALCR_HUMAN Calcitonin receptor (sprot)

A calcitonin receptor that is encoded in the genome of human.


RAMP1_HUMAN Receptor activity-modifying protein 1 (sprot)

A receptor activity-modifying protein 1 that is encoded in the genome of human.


RAMP3_HUMAN Receptor activity-modifying protein 3 (sprot)

A receptor activity-modifying protein 3 that is encoded in the genome of human.


R1AB_MERS1 Replicase polyprotein 1ab (sprot)


GST26_SCHJA Glutathione S-transferase class-mu 26 kDa isozyme (sprot)


Q95US7_SCHMA High voltage-activated calcium channel beta subunit CavB1 (trembl)


Q962H3_SCHMA High voltage-activated calcium channel beta subunit CavB2 (trembl)


IL6_HUMAN Interleukin-6 (sprot)

An interleukin-6 that is encoded in the genome of human.


GPBAR_HUMAN G-protein coupled bile acid receptor 1 (sprot)

A G-protein coupled bile acid receptor 1 that is encoded in the genome of human.


GLNA_HUMAN Glutamine synthetase (sprot)

A glutamine synthetase that is encoded in the genome of human.


ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (sprot)

An ADAM 17 endopeptidase that is encoded in the genome of human.


Pregnenolone succinate

A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.


Prenalterol

A partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute CARDIAC FAILURE, postmyocardial infarction low-output syndrome, SHOCK, and reducing ORTHOSTATIC HYPOTENSION in the SHY-RAGER SYNDROME.


Prenylamine

A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)


Pridinol

antispasmodic & muscle relaxant; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7539

A piperidine substituted at position 1 by a 3-hydroxy-3,3-diphenylpropyl group.


AHR_HUMAN Aryl hydrocarbon receptor (sprot)

An aryl hydrocarbon receptor that is encoded in the genome of human.


TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 (sprot)

A transient receptor potential cation channel TRPV2 that is encoded in the genome of rat.


ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 (sprot)

A phospholipid-transporting ATPase ABCA1 that is encoded in the genome of human.


(R,S)-Procaterol

A long-acting beta-2-adrenergic receptor agonist.


SOAT1_HUMAN Sterol O-acyltransferase 1 (sprot)

A sterol O-acyltransferase 1 that is encoded in the genome of human.


Proscillaridin

A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).


Proglumide

A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.

A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.


Q0IJY2_PLAMA Bifunctional dihydrofolate reductase-thymidylate synthase (trembl)


DRTS_PLAVI Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


Promegestone

A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.

A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.


IOD1_HUMAN Type I iodothyronine deiodinase (sprot)

A type I iodothyronine deiodinase that is encoded in the genome of human.


Propyphenazone

A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.


Protirelin

A tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence.


Q9ERT1_MOUSE Thyrotropin-releasing hormone receptor (Fragment) (trembl)


CMAS1_MYCTO Cyclopropane mycolic acid synthase 1 (sprot)


Q50575_MYCTX Bifunctional pyrazinamidase/nicotinamidase (trembl)


P95029_MYCTU Probable fatty acid synthase Fas (Fatty acid synthetase) (trembl)


DYR_CANAX Dihydrofolate reductase (sprot)


DRTS_TRYCR Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


DRTS_TRYBB Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


S22A1_MOUSE Solute carrier family 22 member 1 (sprot)

A solute carrier family 22 member 1 that is encoded in the genome of mouse.


S47A1_MOUSE Multidrug and toxin extrusion protein 1 (sprot)

A multidrug and toxin extrusion protein 1 that is encoded in the genome of mouse.


HEXA_HUMAN Beta-hexosaminidase subunit alpha (sprot)

A beta-hexosaminidase subunit alpha that is encoded in the genome of human.


HEXB_HUMAN Beta-hexosaminidase subunit beta (sprot)

A beta-hexosaminidase subunit beta that is encoded in the genome of human.


S47A2_MOUSE Multidrug and toxin extrusion protein 2 (sprot)

A multidrug resistance protein MdtK that is encoded in the genome of mouse.


Q8I1R6_PLAF7 Bifunctional dihydrofolate reductase-thymidylate synthase (trembl)


Pyrvinium

A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a  anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.


F1KRD8_ASCSU Fumarate reductase (trembl)


SYNJ1_HUMAN Synaptojanin-1 (sprot)

A synaptojanin-1 that is encoded in the genome of human.


RPOA_ECOLI DNA-directed RNA polymerase subunit alpha (sprot)

A DNA-directed RNA polymerase subunit alpha that is encoded in the genome of Escherichia coli K-12.


RPOZ_ECOLI DNA-directed RNA polymerase subunit omega (sprot)

A DNA-directed RNA polymerase subunit omega that is encoded in the genome of Escherichia coli K-12.


RPOC_ECOLI DNA-directed RNA polymerase subunit beta' (sprot)

A DNA-directed RNA polymerase subunit beta' that is encoded in the genome of Escherichia coli K-12.


RPOB_ECOLI DNA-directed RNA polymerase subunit beta (sprot)

A DNA-directed RNA polymerase subunit beta that is encoded in the genome of Escherichia coli K-12.


PA21B_PIG Phospholipase A2, major isoenzyme (sprot)

A phospholipase A2 that is encoded in the genome of pig.


PA21B_RAT Phospholipase A2 (sprot)

A phospholipase A2 that is encoded in the genome of rat.


PLD1_HUMAN Phospholipase D1 (sprot)

A phospholipase D1 that is encoded in the genome of human.


PLD2_HUMAN Phospholipase D2 (sprot)

A phospholipase D2 that is encoded in the genome of human.


CCR1_HUMAN C-C chemokine receptor type 1 (sprot)

A C-C chemokine receptor type 1 that is encoded in the genome of human.


Q76353_9HIV1 Integrase (Fragment) (trembl)


PD2R2_RAT Prostaglandin D2 receptor 2 (sprot)

A prostaglandin D2 receptor DP2 that is encoded in the genome of rat.


Q5YLN7_CANLF Voltage-gated sodium channel Nav1.5 cardiac isoform (Fragment) (trembl)


Remoxipride

An antipsychotic agent that is specific for dopamine D2 receptors. It has been shown to be effective in the treatment of schizophrenia.


VMAT2_BOVIN Synaptic vesicular amine transporter (sprot)

A synaptic vesicular amine transporter that is encoded in the genome of cow.


RET4_HUMAN Retinol-binding protein 4 (sprot)

A retinol-binding protein 4 that is encoded in the genome of human.


LACB_BOVIN Beta-lactoglobulin (sprot)

A glycodelin that is encoded in the genome of cow.


ENPP1_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (sprot)

An ectonucleotide pyrophosphatase/phosphodiesterase family member 1 that is encoded in the genome of human.


5NTC_HUMAN Cytosolic purine 5'-nucleotidase (sprot)

A cytosolic purine 5'-nucleotidase that is encoded in the genome of human.


Q8JXU8_9HEPC RNA-directed RNA polymerase (Fragment) (trembl)


AA1R_MOUSE Adenosine receptor A1 (sprot)

An adenosine receptor A1 that is encoded in the genome of mouse.


RPOB_MYCTU DNA-directed RNA polymerase subunit beta (sprot)


KCNN3_HUMAN Small conductance calcium-activated potassium channel protein 3 (sprot)

A small conductance calcium-activated potassium channel protein 3 that is encoded in the genome of human.


KCNN1_HUMAN Small conductance calcium-activated potassium channel protein 1 (sprot)

A small conductance calcium-activated potassium channel protein 1 that is encoded in the genome of human.


M2_I60A0 Matrix protein 2 (sprot)

An influenzavirus matrix protein 2 that is encoded in the genome of the H2N2 strain A/Ann Arbor/6/1960.


Q197X6_TOXGO Farnesyl diphosphate synthase (trembl)


Q8WS26_TRYCR Farnesyl diphosphate synthase (trembl)


BT3A1_HUMAN Butyrophilin subfamily 3 member A1 (sprot)

A butyrophilin subfamily 3 member A1 that is encoded in the genome of human.


Levisoprenaline

An optically active phenylethanolamine compound having an isopropyl substituent attached to the nitrogen atom.


ACHE_RAT Acetylcholine receptor subunit epsilon (sprot)

An acetylcholine receptor subunit epsilon that is encoded in the genome of rat.


CHLE_CANLF Cholinesterase (Fragment) (sprot)


5HT1D_PIG 5-hydroxytryptamine receptor 1D (Fragment) (sprot)


ROLITETRACYCLINE

A derivative of tetracycline in which the amide function is substituted with a pyrrolidinomethyl group.


DCAM_RAT S-adenosylmethionine decarboxylase proenzyme (sprot)

A SAM decarboxylase proenzyme that is encoded in the genome of rat.


PNMT_HUMAN Phenylethanolamine N-methyltransferase (sprot)

A phenylethanolamine N-methyltransferase that is encoded in the genome of human.


PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase (sprot)

A protein-L-isoaspartate(D-aspartate) O-methyltransferase that is encoded in the genome of human.


SABP2_TOBAC Salicylic acid-binding protein 2 (sprot)


AOFB_BOVIN Amine oxidase [flavin-containing] B (sprot)

An amine oxidase [flavin-containing] B that is encoded in the genome of cow.


Seratrodast

has thromboxane A2 & prostaglandin H2 receptor antagonistic action


PDE9A_HUMAN High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (sprot)

A high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A that is encoded in the genome of human.


PDE5A_RAT cGMP-specific 3',5'-cyclic phosphodiesterase (sprot)

A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of rat.


PDE6C_BOVIN Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (sprot)

A cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' that is encoded in the genome of cow.


PDE6A_BOVIN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (sprot)

A rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha that is encoded in the genome of cow.


PDE5A_CANLF cGMP-specific 3',5'-cyclic phosphodiesterase (sprot)


PDE4D_RAT cAMP-specific 3',5'-cyclic phosphodiesterase 4D (sprot)

A cAMP-specific 3',5'-cyclic phosphodiesterase 4D that is encoded in the genome of rat.


PDE4C_RAT cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Fragment) (sprot)


PDE4B_RAT cAMP-specific 3',5'-cyclic phosphodiesterase 4B (sprot)

A protein that is a translation product of the Pde4b gene in rat.


PDE4A_RAT cAMP-specific 3',5'-cyclic phosphodiesterase 4A (sprot)

A cAMP-specific 3',5'-cyclic phosphodiesterase 4A that is encoded in the genome of rat.


CNRG_BOVIN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)

A protein that is a translation product of the PDE6G gene in cow.


CNCG_BOVIN Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)

A retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma that is encoded in the genome of cow.


PDE6D_BOVIN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (sprot)

A retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta that is encoded in the genome of cow.


PDE6B_BOVIN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (sprot)

A rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta that is encoded in the genome of cow.


PDE2A_BOVIN cGMP-dependent 3',5'-cyclic phosphodiesterase (sprot)


Silibinin

A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.

A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.


GLUT4_MOUSE Solute carrier family 2, facilitated glucose transporter member 4 (sprot)

A solute carrier family 2, facilitated glucose transporter member 4 that is encoded in the genome of mouse.


HMDH_SCHPO 3-hydroxy-3-methylglutaryl-coenzyme A reductase (sprot)

A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is encoded in the genome of Schizosaccharomyces pombe 972h-.


FKBP3_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP3 (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP3 that is encoded in the genome of human.


FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP5 that is encoded in the genome of human.


PDCD4_HUMAN Programmed cell death protein 4 (sprot)

A programmed cell death protein 4 that is encoded in the genome of human.


IF4E_HUMAN Eukaryotic translation initiation factor 4E (sprot)

A eukaryotic translation initiation factor 4E that is encoded in the genome of human.


FKB1A_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP1A (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP1A that is encoded in the genome of mouse.


MTOR_MOUSE Serine/threonine-protein kinase mTOR (sprot)

A serine/threonine-protein kinase mTOR that is encoded in the genome of mouse.


Sisomicin

Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).


DPP4_RAT Dipeptidyl peptidase 4 (sprot)

A dipeptidyl peptidase 4 that is encoded in the genome of rat.


DPP4_MOUSE Dipeptidyl peptidase 4 (sprot)

A dipeptidyl peptidase 4 that is encoded in the genome of mouse.


SEPR_HUMAN Prolyl endopeptidase FAP (sprot)

A prolyl endopeptidase FAP that is encoded in the genome of human.


DPP8_HUMAN Dipeptidyl peptidase 8 (sprot)

A dipeptidyl peptidase 8 that is encoded in the genome of human.


DPP9_HUMAN Dipeptidyl peptidase 9 (sprot)

A dipeptidyl peptidase 9 that is encoded in the genome of human.


DPP2_HUMAN Dipeptidyl peptidase 2 (sprot)

A dipeptidyl peptidase 2 that is encoded in the genome of human.


O31048_PORGN Dipeptidyl peptidase IV (trembl)


Beta-Sitosterol

used as tranquillizer; sedative; or anticonvulsant; structure

A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.


PRTN3_HUMAN Myeloblastin (sprot)

A myeloblastin that is encoded in the genome of human.


ELNE_MOUSE Neutrophil elastase (sprot)

A neutrophil elastase that is encoded in the genome of mouse.


CDK5_HUMAN Cyclin-dependent kinase 5 (sprot)

A cyclin-dependent kinase 5 that is encoded in the genome of human.


CDK15_HUMAN Cyclin-dependent kinase 15 (sprot)

A cyclin-dependent kinase 15 that is encoded in the genome of human.


CDK6_HUMAN Cyclin-dependent kinase 6 (sprot)

A cyclin-dependent kinase 6 that is encoded in the genome of human.


KS6A6_HUMAN Ribosomal protein S6 kinase alpha-6 (sprot)

A ribosomal protein S6 kinase alpha-6 that is encoded in the genome of human.


CDK17_HUMAN Cyclin-dependent kinase 17 (sprot)

A cyclin-dependent kinase 17 that is encoded in the genome of human.


CDK14_HUMAN Cyclin-dependent kinase 14 (sprot)

A cyclin-dependent kinase 14 that is encoded in the genome of human.


STK33_HUMAN Serine/threonine-protein kinase 33 (sprot)

A serine/threonine-protein kinase 33 that is encoded in the genome of human.


CDK8_HUMAN Cyclin-dependent kinase 8 (sprot)

A cyclin-dependent kinase 8 that is encoded in the genome of human.


MUSK_HUMAN Muscle, skeletal receptor tyrosine-protein kinase (sprot)

A muscle, skeletal receptor tyrosine-protein kinase that is encoded in the genome of human.


MYO3B_HUMAN Myosin-IIIb (sprot)

A myosin-IIIB that is encoded in the genome of human.


CDK3_HUMAN Cyclin-dependent kinase 3 (sprot)

A cyclin-dependent kinase 3 that is encoded in the genome of human.


MK15_HUMAN Mitogen-activated protein kinase 15 (sprot)

A mitogen-activated protein kinase 15 that is encoded in the genome of human.


RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (sprot)

A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human.


KC1A_HUMAN Casein kinase I isoform alpha (sprot)

A casein kinase I isoform alpha that is encoded in the genome of human.


CDKL2_HUMAN Cyclin-dependent kinase-like 2 (sprot)

A cyclin-dependent kinase-like 2 that is encoded in the genome of human.


CDKL3_HUMAN Cyclin-dependent kinase-like 3 (sprot)

A cyclin-dependent kinase-like 3 that is encoded in the genome of human.


HIPK2_HUMAN Homeodomain-interacting protein kinase 2 (sprot)

A homeodomain-interacting protein kinase 2 that is encoded in the genome of human.


HIPK3_HUMAN Homeodomain-interacting protein kinase 3 (sprot)

A homeodomain-interacting protein kinase 3 that is encoded in the genome of human.


HIPK1_HUMAN Homeodomain-interacting protein kinase 1 (sprot)

A homeodomain-interacting protein kinase 1 that is encoded in the genome of human.


MYLK3_HUMAN Myosin light chain kinase 3 (sprot)

A myosin light chain kinase 3 that is encoded in the genome of human.


VGFR2_MOUSE Vascular endothelial growth factor receptor 2 (sprot)

A vascular endothelial growth factor receptor 2 that is encoded in the genome of mouse.


VGFR2_DANRE Vascular endothelial growth factor receptor 2 (sprot)

A vascular endothelial growth factor receptor 2 that is encoded in the genome of zebrafish.


ARAF_HUMAN Serine/threonine-protein kinase A-Raf (sprot)

A serine/threonine-protein kinase A-Raf that is encoded in the genome of human.


PNPH_PLAFA Purine nucleoside phosphorylase (sprot)


VGFR3_MOUSE Vascular endothelial growth factor receptor 3 (sprot)

A vascular endothelial growth factor receptor 3 that is encoded in the genome of mouse.


PGFRB_MOUSE Platelet-derived growth factor receptor beta (sprot)

A beta-type platelet-derived growth factor receptor that is encoded in the genome of mouse.


DNK_DROME Deoxynucleoside kinase (sprot)

A thymidine kinase 2, mitochondrial that is encoded in the genome of fruit fly.


KITM_HUMAN Thymidine kinase 2, mitochondrial (sprot)

A thymidine kinase 2, mitochondrial that is encoded in the genome of human.


DRD3_MOUSE D(3) dopamine receptor (sprot)

A D(3) dopamine receptor that is encoded in the genome of mouse.


DRD4_MOUSE D(4) dopamine receptor (sprot)

A D(4) dopamine receptor that is encoded in the genome of mouse.


DRD5_MOUSE D(1B) dopamine receptor (sprot)

A D(1B) dopamine receptor that is encoded in the genome of mouse.


CASB_RAT Beta-casein (sprot)

A beta-casein that is encoded in the genome of rat.


RS12_MYCTO Small ribosomal subunit protein uS12 (sprot)


Strychnine

An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.

A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.


GLRA1_RAT Glycine receptor subunit alpha-1 (sprot)

A glycine receptor subunit alpha-1 that is encoded in the genome of rat.


EGLN1_HUMAN Egl nine homolog 1 (sprot)

An egl nine homolog 1 that is encoded in the genome of human.


SUCR1_HUMAN Succinate receptor 1 (sprot)

A succinate receptor 1 that is encoded in the genome of human.


LACTB_HUMAN Serine beta-lactamase-like protein LACTB, mitochondrial (sprot)

A serine beta-lactamase-like protein LACTB, mitochondrial that is encoded in the genome of human.


DAPK2_HUMAN Death-associated protein kinase 2 (sprot)

A death-associated protein kinase 2 that is encoded in the genome of human.


Q25704_PLAFA 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase (trembl)


PYRD_PLAF7 Dihydroorotate dehydrogenase (quinone), mitochondrial (sprot)


SC5A7_HUMAN High affinity choline transporter 1 (sprot)

A high affinity choline transporter 1 that is encoded in the genome of human.


Sulfadimethoxine

A sulfanilamide that is used as an anti-infective agent.

A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.


Q8IAU3_PLAF7 Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase (trembl)


Sulfaethidole

minor descriptor (66-86); on-line & INDEX MEDICUS search SULFATHIAZOLES (66-86); RN given refers to parent cpd


Sulfaguanidine

A sulfanilamide antimicrobial agent that is used to treat enteric infections.

A sulfonamide incorporating a guanidine moiety used to block the synthesis of folic acid; mostly used in veterinary medicine


AGO2_HUMAN Protein argonaute-2 (sprot)

A protein argonaute-2 that is encoded in the genome of human.


Sulfameter

Long acting sulfonamide used in leprosy, urinary, and respiratory tract infections.

A sulfonamide consisting of pyrimidine having a methoxy substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 2-position.


FOLC_ECOLI Dihydrofolate synthase/folylpolyglutamate synthase (sprot)

A dihydrofolate synthase/folylpolyglutamate synthase that is encoded in the genome of Escherichia coli K-12.


Sulfalene

Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.


Sulfaphenazole

A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.


DHP1_MYCFO Dihydropteroate synthase type-1 (sprot)


THIL_HUMAN Acetyl-CoA acetyltransferase, mitochondrial (sprot)

An acetyl-CoA acetyltransferase, mitochondrial that is encoded in the genome of human.


Sulfisomidine

A sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.


LASR_PSEAE Transcriptional activator protein LasR (sprot)

A protein that is a translation product of the lasR gene in Pseudomonas aeruginosa PAO1.


HPGDS_HUMAN Hematopoietic prostaglandin D synthase (sprot)

A glutathione-requiring prostaglandin D synthase that is encoded in the genome of human.


Suloctidil

A peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)


DRD2_CANLF D(2) dopamine receptor (sprot)

A D(2) dopamine receptor that is encoded in the genome of dog.


5HT1B_GORGO 5-hydroxytryptamine receptor 1B (sprot)


Q8MI13_BOVIN 5-hydroxytryptamine 1D receptor (Fragment) (trembl)


PDXK_HUMAN Pyridoxal kinase (sprot)

A pyridoxal kinase that is encoded in the genome of human.


KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (sprot)

A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of human.


KCC1A_HUMAN Calcium/calmodulin-dependent protein kinase type 1 (sprot)

A calcium/calmodulin-dependent protein kinase type 1 that is encoded in the genome of human.


JAK1_HUMAN Tyrosine-protein kinase JAK1 (sprot)

A tyrosine-protein kinase JAK1 that is encoded in the genome of human.


KPCA_HUMAN Protein kinase C alpha type (sprot)

A protein kinase C alpha type that is encoded in the genome of human.


KCC2G_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit gamma (sprot)

A calcium/calmodulin-dependent protein kinase type II subunit gamma that is encoded in the genome of human.


MARK2_HUMAN Serine/threonine-protein kinase MARK2 (sprot)

A serine/threonine-protein kinase MARK2 that is encoded in the genome of human.


KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 (sprot)

A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human.


AAPK1_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-1 (sprot)

A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of human.


KCC2B_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit beta (sprot)

A calcium/calmodulin-dependent protein kinase type II subunit beta that is encoded in the genome of human.


KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (sprot)

A calcium/calmodulin-dependent protein kinase type II subunit alpha that is encoded in the genome of human.


FER_HUMAN Tyrosine-protein kinase Fer (sprot)

A tyrosine-protein kinase Fer that is encoded in the genome of human.


STK16_HUMAN Serine/threonine-protein kinase 16 (sprot)

A serine/threonine-protein kinase 16 that is encoded in the genome of human.


PIM2_HUMAN Serine/threonine-protein kinase pim-2 (sprot)

A serine/threonine-protein kinase Pim-2 that is encoded in the genome of human.


CLK2_HUMAN Dual specificity protein kinase CLK2 (sprot)

A dual specificity protein kinase CLK2 that is encoded in the genome of human.


ST38L_HUMAN Serine/threonine-protein kinase 38-like (sprot)

A serine/threonine-protein kinase 38-like that is encoded in the genome of human.


KCC1D_HUMAN Calcium/calmodulin-dependent protein kinase type 1D (sprot)

A calcium/calmodulin-dependent protein kinase type 1D that is encoded in the genome of human.


CDK16_HUMAN Cyclin-dependent kinase 16 (sprot)

A cyclin-dependent kinase 16 that is encoded in the genome of human.


KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 (sprot)

A calcium/calmodulin-dependent protein kinase kinase 2 that is encoded in the genome of human.


MARK3_HUMAN MAP/microtubule affinity-regulating kinase 3 (sprot)

A MAP/microtubule affinity-regulating kinase 3 that is encoded in the genome of human.


KKCC1_HUMAN Calcium/calmodulin-dependent protein kinase kinase 1 (sprot)

A calcium/calmodulin-dependent protein kinase kinase 1 that is encoded in the genome of human.


KCC1G_HUMAN Calcium/calmodulin-dependent protein kinase type 1G (sprot)

A calcium/calmodulin-dependent protein kinase type 1G that is encoded in the genome of human.


TSSK1_HUMAN Testis-specific serine/threonine-protein kinase 1 (sprot)

A testis-specific serine/threonine-protein kinase 1 that is encoded in the genome of human.


STK3_MOUSE Serine/threonine-protein kinase 3 (sprot)

A serine/threonine-protein kinase 3 that is encoded in the genome of mouse.


KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (sprot)

A ribosomal protein S6 kinase beta-1 that is encoded in the genome of human.


AKT2_HUMAN RAC-beta serine/threonine-protein kinase (sprot)

A RAC-beta serine/threonine-protein kinase that is encoded in the genome of human.


STK3_HUMAN Serine/threonine-protein kinase 3 (sprot)

A serine/threonine-protein kinase 3 that is encoded in the genome of human.


CHK1_HUMAN Serine/threonine-protein kinase Chk1 (sprot)

A serine/threonine-protein kinase Chk1 that is encoded in the genome of human.


PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (sprot)

A serine/threonine-protein kinase PAK 3 that is encoded in the genome of human.


CDK18_HUMAN Cyclin-dependent kinase 18 (sprot)

A cyclin-dependent kinase 18 that is encoded in the genome of human.


PI51A_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (sprot)

A phosphatidylinositol 4-phosphate 5-kinase type-1 alpha that is encoded in the genome of human.


PI42B_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (sprot)

A phosphatidylinositol 5-phosphate 4-kinase type-2 beta that is encoded in the genome of human.


MYLK4_HUMAN Myosin light chain kinase family member 4 (sprot)

A myosin light chain kinase family member 4 that is encoded in the genome of human.


FAK2_HUMAN Protein-tyrosine kinase 2-beta (sprot)

A focal adhesion kinase 2 that is encoded in the genome of human.


RIOK1_HUMAN Serine/threonine-protein kinase RIO1 (sprot)

A serine/threonine-protein kinase RIO1 that is encoded in the genome of human.


KC1AL_HUMAN Casein kinase I isoform alpha-like (sprot)

A casein kinase I isoform alpha-like that is encoded in the genome of human.


KC1G2_HUMAN Casein kinase I isoform gamma-2 (sprot)

A casein kinase I isoform gamma-2 that is encoded in the genome of human.


KC1G3_HUMAN Casein kinase I isoform gamma-3 (sprot)

A casein kinase I isoform gamma-3 that is encoded in the genome of human.


TLK1_HUMAN Serine/threonine-protein kinase tousled-like 1 (sprot)

A serine/threonine-protein kinase tousled-like 1 that is encoded in the genome of human.


TLK2_HUMAN Serine/threonine-protein kinase tousled-like 2 (sprot)

A serine/threonine-protein kinase tousled-like 2 that is encoded in the genome of human.


CSK21_HUMAN Casein kinase II subunit alpha (sprot)

A casein kinase II subunit alpha that is encoded in the genome of human.


DYR1B_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1B (sprot)

A dual specificity tyrosine-phosphorylation-regulated kinase 1B that is encoded in the genome of human.


STK11_HUMAN Serine/threonine-protein kinase STK11 (sprot)

A serine/threonine-protein kinase STK11 that is encoded in the genome of human.


MP2K3_HUMAN Dual specificity mitogen-activated protein kinase kinase 3 (sprot)

A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of human.


NEK7_HUMAN Serine/threonine-protein kinase Nek7 (sprot)

A serine/threonine-protein kinase Nek7 that is encoded in the genome of human.


INSRR_HUMAN Insulin receptor-related protein (sprot)

An insulin receptor-related protein that is encoded in the genome of human.


RIOK3_HUMAN Serine/threonine-protein kinase RIO3 (sprot)

A serine/threonine-protein kinase RIO3 that is encoded in the genome of human.


SRPK1_HUMAN SRSF protein kinase 1 (sprot)

An SRSF protein kinase 1 that is encoded in the genome of human.


SRPK2_HUMAN SRSF protein kinase 2 (sprot)

An SRSF protein kinase 2 that is encoded in the genome of human.


AAPK2_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-2 (sprot)

A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that is encoded in the genome of human.


ANKK1_HUMAN Ankyrin repeat and protein kinase domain-containing protein 1 (sprot)

An ankyrin repeat and protein kinase domain-containing protein 1 that is encoded in the genome of human.


LATS2_HUMAN Serine/threonine-protein kinase LATS2 (sprot)

A serine/threonine-protein kinase LATS2 that is encoded in the genome of human.


PAK6_HUMAN Serine/threonine-protein kinase PAK 6 (sprot)

A serine/threonine-protein kinase PAK 6 that is encoded in the genome of human.


PAK5_HUMAN Serine/threonine-protein kinase PAK 5 (sprot)

A serine/threonine-protein kinase PAK 5 that is encoded in the genome of human.


NUAK1_HUMAN NUAK family SNF1-like kinase 1 (sprot)

A NUAK family SNF1-like kinase 1 that is encoded in the genome of human.


BMPR2_HUMAN Bone morphogenetic protein receptor type-2 (sprot)

A BMP receptor type-2 that is encoded in the genome of human.


BRSK1_HUMAN Serine/threonine-protein kinase BRSK1 (sprot)

A serine/threonine-protein kinase BRSK1 that is encoded in the genome of human.


MARK1_HUMAN Serine/threonine-protein kinase MARK1 (sprot)

A serine/threonine-protein kinase MARK1 that is encoded in the genome of human.


MARK4_HUMAN MAP/microtubule affinity-regulating kinase 4 (sprot)

A MAP/microtubule affinity-regulating kinase 4 that is encoded in the genome of human.


MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 (sprot)

A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of human.


KCC4_HUMAN Calcium/calmodulin-dependent protein kinase type IV (sprot)

A calcium/calmodulin-dependent protein kinase type IV that is encoded in the genome of human.


MYLK_CHICK Myosin light chain kinase, smooth muscle (sprot)

A myosin light chain kinase, smooth muscle that is encoded in the genome of chicken.


M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 (sprot)

A mitogen-activated protein kinase kinase kinase 9 that is encoded in the genome of human.


M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 (sprot)

A mitogen-activated protein kinase kinase kinase 11 that is encoded in the genome of human.


STK24_HUMAN Serine/threonine-protein kinase 24 (sprot)

A serine/threonine-protein kinase 24 that is encoded in the genome of human.


KC1G1_HUMAN Casein kinase I isoform gamma-1 (sprot)

A casein kinase I isoform gamma-1 that is encoded in the genome of human.


DAPK1_HUMAN Death-associated protein kinase 1 (sprot)

A death-associated protein kinase 1 that is encoded in the genome of human.


DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 (sprot)

A serine/threonine-protein kinase DCLK1 that is encoded in the genome of human.


DCLK2_HUMAN Serine/threonine-protein kinase DCLK2 (sprot)

A serine/threonine-protein kinase DCLK2 that is encoded in the genome of human.


MYO3A_HUMAN Myosin-IIIa (sprot)

A myosin-IIIa that is encoded in the genome of human.


BRSK2_HUMAN Serine/threonine-protein kinase BRSK2 (sprot)

A serine/threonine-protein kinase BRSK2 that is encoded in the genome of human.


MK07_HUMAN Mitogen-activated protein kinase 7 (sprot)

A mitogen-activated protein kinase 7 that is encoded in the genome of human.


FES_HUMAN Tyrosine-protein kinase Fes/Fps (sprot)

A tyrosine-protein kinase Fes/Fps that is encoded in the genome of human.


FGFR4_HUMAN Fibroblast growth factor receptor 4 (sprot)

A fibroblast growth factor receptor 4 that is encoded in the genome of human.


KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 (sprot)

A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human.


PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (sprot)

A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform that is encoded in the genome of human.


CDK4_HUMAN Cyclin-dependent kinase 4 (sprot)

A cell division protein kinase 4 that is encoded in the genome of human.


DLK1_HUMAN Protein delta homolog 1 (sprot)

A protein delta homolog 1 that is encoded in the genome of human.


DYR1A_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1A (sprot)

A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of human.


ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (sprot)

A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human.


GRK1_HUMAN Rhodopsin kinase GRK1 (sprot)

A rhodopsin kinase GRK1 that is encoded in the genome of human.


GRK7_HUMAN Rhodopsin kinase GRK7 (sprot)

A rhodopsin kinase GRK7 that is encoded in the genome of human.


HUNK_HUMAN Hormonally up-regulated neu tumor-associated kinase (sprot)

A hormonally up-regulated neu tumor-associated kinase that is encoded in the genome of human.


CILK1_HUMAN Serine/threonine-protein kinase ICK (sprot)

A serine/threonine-protein kinase ICK that is encoded in the genome of human.


IKKA_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit alpha (sprot)

An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human.


MAST1_HUMAN Microtubule-associated serine/threonine-protein kinase 1 (sprot)

A microtubule-associated serine/threonine-protein kinase 1 that is encoded in the genome of human.


STK38_HUMAN Serine/threonine-protein kinase 38 (sprot)

A serine/threonine-protein kinase 38 that is encoded in the genome of human.


NIM1_HUMAN Serine/threonine-protein kinase NIM1 (sprot)

A serine/threonine-protein kinase NIM1 that is encoded in the genome of human.


OXSR1_HUMAN Serine/threonine-protein kinase OSR1 (sprot)

A serine/threonine-protein kinase OSR1 that is encoded in the genome of human.


PRP4_HUMAN U4/U6 small nuclear ribonucleoprotein Prp4 (sprot)

A U4/U6 small nuclear ribonucleoprotein Prp4 that is encoded in the genome of human.


RIOK2_HUMAN Serine/threonine-protein kinase RIO2 (sprot)

A serine/threonine-protein kinase RIO2 that is encoded in the genome of human.


STK39_HUMAN STE20/SPS1-related proline-alanine-rich protein kinase (sprot)

A STE20/SPS1-related proline-alanine-rich protein kinase that is encoded in the genome of human.


ULK1_HUMAN Serine/threonine-protein kinase ULK1 (sprot)

A serine/threonine-protein kinase ULK1 that is encoded in the genome of human.


ULK2_HUMAN Serine/threonine-protein kinase ULK2 (sprot)

A serine/threonine-protein kinase ULK2 that is encoded in the genome of human.


M3K15_HUMAN Mitogen-activated protein kinase kinase kinase 15 (sprot)

A mitogen-activated protein kinase kinase kinase 15 that is encoded in the genome of human.


PLK2_HUMAN Serine/threonine-protein kinase PLK2 (sprot)

A serine/threonine-protein kinase PLK2 that is encoded in the genome of human.


SBK3_HUMAN Uncharacterized serine/threonine-protein kinase SBK3 (sprot)

An uncharacterized serine/threonine-protein kinase SBK3 that is encoded in the genome of human.


TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (sprot)

A poly [ADP-ribose] polymerase tankyrase-2 that is encoded in the genome of human.


MATK_HUMAN Megakaryocyte-associated tyrosine-protein kinase (sprot)

A megakaryocyte-associated tyrosine-protein kinase that is encoded in the genome of human.


PRP4B_HUMAN Serine/threonine-protein kinase PRP4 homolog (sprot)

A serine/threonine-protein kinase PRP4 that is encoded in the genome of human.


M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 (sprot)

A mitogen-activated protein kinase kinase kinase 12 that is encoded in the genome of human.


SGK3_HUMAN Serine/threonine-protein kinase Sgk3 (sprot)

A serine/threonine-protein kinase Sgk3 that is encoded in the genome of human.


SNRK_HUMAN SNF-related serine/threonine-protein kinase (sprot)

An SNF-related serine/threonine-protein kinase that is encoded in the genome of human.


DUSTY_HUMAN Dual serine/threonine and tyrosine protein kinase (sprot)

A dual serine/threonine and tyrosine protein kinase that is encoded in the genome of human.


PKNB_MYCTU Serine/threonine-protein kinase PknB (sprot)

A protein that is a translation product of the pknB gene in Mycobacterium tuberculosis H37Rv.


BRD9_HUMAN Bromodomain-containing protein 9 (sprot)

A bromodomain-containing protein 9 that is encoded in the genome of human.


ERCC2_HUMAN General transcription and DNA repair factor IIH helicase subunit XPD (sprot)

A general transcription and DNA repair factor IIH helicase subunit XPD that is encoded in the genome of human.


GRK6_HUMAN G protein-coupled receptor kinase 6 (sprot)

A G protein-coupled receptor kinase 6 that is encoded in the genome of human.


AAKG1_HUMAN 5'-AMP-activated protein kinase subunit gamma-1 (sprot)

A 5'-AMP-activated protein kinase subunit gamma-1 that is encoded in the genome of human.


YJ005_HUMAN Uncharacterized protein FLJ45252 (sprot)

An AAK1 gene translation product (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZSR9-1.


AAKG2_HUMAN 5'-AMP-activated protein kinase subunit gamma-2 (sprot)

A 5'-AMP-activated protein kinase subunit gamma-2 that is encoded in the genome of human.


GRK5_HUMAN G protein-coupled receptor kinase 5 (sprot)

A G protein-coupled receptor kinase 5 that is encoded in the genome of human.


SCTR_HUMAN Secretin receptor (sprot)

A secretin receptor that is encoded in the genome of human.


HNMT_RAT Histamine N-methyltransferase (sprot)

A histamine N-methyltransferase that is encoded in the genome of rat.


SF3B3_HUMAN Splicing factor 3B subunit 3 (sprot)

A splicing factor 3B subunit 3 that is encoded in the genome of human.


FKB10_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP10 (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP10 that is encoded in the genome of human.


CATL1_HUMAN Procathepsin L (sprot)

A procathepsin L that is encoded in the genome of human.


ERG1_RAT Squalene monooxygenase (sprot)

A squalene monooxygenase that is encoded in the genome of rat.


EBPL_HUMAN Emopamil-binding protein-like (sprot)

An emopamil-binding protein-like that is encoded in the genome of human.


DHCR7_HUMAN 7-dehydrocholesterol reductase (sprot)

A 7-dehydrocholesterol reductase that is encoded in the genome of human.


HMOX1_RAT Heme oxygenase 1 (sprot)

A heme oxygenase 1 that is encoded in the genome of rat.


CP2J2_HUMAN Cytochrome P450 2J2 (sprot)

A cytochrome P450 2J2 that is encoded in the genome of human.


CNGA1_BOVIN cGMP-gated cation channel alpha-1 (sprot)

A cGMP-gated cation channel alpha-1 that is encoded in the genome of cow.


A phenylalanine-4-hydroxylase that is encoded in the genome of human.


CRBN_HUMAN Protein cereblon (sprot)

A protein cereblon that is encoded in the genome of human.


TMIG3_HUMAN Transmembrane domain-containing protein TMIGD3 (sprot)

A transmembrane domain-containing protein TMIGD3 that is encoded in the genome of human.


SDHA_CAEEL Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sprot)

A protein that is a translation product of the sdha-1 gene in worm.


MAP1_ECOLI Methionine aminopeptidase (sprot)

A methionine aminopeptidase that is encoded in the genome of Escherichia coli K-12.


Thiamphenicol

A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent.


HPPK_ECOLI 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (sprot)

A 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase that is encoded in the genome of Escherichia coli K-12.


KCNC4_RAT Potassium voltage-gated channel subfamily C member 4 (sprot)

A voltage-gated potassium channel KCNC4 that is encoded in the genome of rat.


Thioproperazine

A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10.


MDHM_HUMAN Malate dehydrogenase, mitochondrial (sprot)

A malate dehydrogenase, mitochondrial that is encoded in the genome of human.


S6A12_MOUSE Sodium- and chloride-dependent betaine transporter (sprot)

A sodium- and chloride-dependent betaine transporter that is encoded in the genome of mouse.


VPP3_HUMAN V-type proton ATPase 116 kDa subunit a 3 (sprot)

A V-type proton ATPase 116 kDa subunit a 3 that is encoded in the genome of human.


MMP14_HUMAN Matrix metalloproteinase-14 (sprot)

A matrix metalloproteinase-14 that is encoded in the genome of human.


O69638_MYCTO Hydrolase, alpha/beta hydrolase fold family (trembl)


POLG_DEN26 Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Thailand/16681/84.


Tolfenamic acid

An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.


Tolonium

A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.

An organic cation that is phenothiazin-5-ium substituted by methyl, amino and dimethylamino groups at positions 2, 3 and 7 respectively. The chloride salt is used as a  histological dye.


P70634_RAT SMR1-alpha3 (Fragment) (trembl)


P70635_RAT BetaB2-crystallin (Fragment) (trembl)


ALDR_PIG Aldo-keto reductase family 1 member B1 (sprot)

A protein that is a translation product of the AKR1B1 gene in pig.


AK1CL_MOUSE Aldo-keto reductase family 1 member C21 (sprot)

An aldo-keto reductase family 1 member C21 that is encoded in the genome of mouse.


CAH2_RAT Carbonic anhydrase 2 (sprot)

A vertebrate-type carbonic anhydrase 2 that is encoded in the genome of rat.


TOP1_MOUSE DNA topoisomerase 1 (sprot)

A type 1B DNA topoisomerase 1 that is encoded in the genome of mouse.


KDM1B_HUMAN Lysine-specific histone demethylase 2 (sprot)

A lysine-specific histone demethylase 2 that is encoded in the genome of human.


RORB_HUMAN Nuclear receptor ROR-beta (sprot)

A nuclear receptor ROR-beta that is encoded in the genome of human.


RABP1_MOUSE Cellular retinoic acid-binding protein 1 (sprot)

A cellular retinoic acid-binding protein 1 that is encoded in the genome of mouse.


RABP2_MOUSE Cellular retinoic acid-binding protein 2 (sprot)

A cellular retinoic acid-binding protein 2 that is encoded in the genome of mouse.


RARA_MOUSE Retinoic acid receptor alpha (sprot)

A retinoic acid receptor alpha that is encoded in the genome of mouse.


RARB_MOUSE Retinoic acid receptor beta (sprot)

A retinoic acid receptor beta that is encoded in the genome of mouse.


RARG_MOUSE Retinoic acid receptor gamma (sprot)

A retinoic acid receptor gamma that is encoded in the genome of mouse.


NR2C2_HUMAN Nuclear receptor subfamily 2 group C member 2 (sprot)

A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human.


PIN1_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (sprot)

A peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 that is encoded in the genome of human.


Tretoquinol

An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.


Triclofos

derivative 7 metabolic precursor of trichloroethanol; RN given refers to parent cpd; structure


PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit (sprot)

A DNA-dependent protein kinase catalytic subunit that is encoded in the genome of human.


LYSC1_RAT Lysozyme C-1 (sprot)

A lysozyme C-2 that is encoded in the genome of rat.


Trifluperidol

A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)


KTHY_MYCTU Thymidylate kinase (sprot)

A protein that is a translation product of the tmk gene in Mycobacterium tuberculosis H37Rv.


3BHS2_HUMAN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (sprot)

A 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 that is encoded in the genome of human.


DRTS_PLABA Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


DYR_YEAST Dihydrofolate reductase (sprot)

A dihydrofolate reductase that is encoded in the genome of yeast.


O30463_MYCAV Dihydrofolate reductase (trembl)


DYR_NEIGO Dihydrofolate reductase (sprot)


DYR_LACLA Dihydrofolate reductase (sprot)


Q27552_CRYPV Bifunctional dihydrofolate reductase-thymidylate synthase (trembl)


DYR1_ECOLX Dihydrofolate reductase type 1 (sprot)

A protein that is a translation product of any of the plasmid-encoded copies of the dhfrI gene in Escherichia coli.


DYR_STRPN Dihydrofolate reductase (sprot)


Q9UUP5_PNEJI Dihydrofolate reductase (trembl)


Triparanol

Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts.


GYS2_HUMAN Glycogen [starch] synthase, liver (sprot)

A glycogen [starch] synthase, liver that is encoded in the genome of human.


LOX15_MOUSE Polyunsaturated fatty acid lipoxygenase ALOX15 (sprot)

A polyunsaturated fatty acid lipoxygenase ALOX15 that is encoded in the genome of mouse.


FOXM1_HUMAN Forkhead box protein M1 (sprot)

A forkhead box protein M1 that is encoded in the genome of human.


5HT3A_CAVPO 5-hydroxytryptamine receptor 3A (sprot)


KCNN2_HUMAN Small conductance calcium-activated potassium channel protein 2 (sprot)

A small conductance calcium-activated potassium channel protein 2 that is encoded in the genome of human.


ZACN_HUMAN Zinc-activated ligand-gated ion channel (sprot)

A zinc-activated ligand-gated ion channel that is encoded in the genome of human.


Tyrosine

A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.

An optically active form of tyrosine having L-configuration.


Ubenimex

growth inhibitor; RN given refers to ((L-Leu)-(S-(R*,S*)))-isomer; structure


AMPN_HUMAN Aminopeptidase N (sprot)

An aminopeptidase N that is encoded in the genome of human.


AMPL_HUMAN Cytosol aminopeptidase (sprot)

A cytosol aminopeptidase that is encoded in the genome of human.


AMPN_PIG Aminopeptidase N (sprot)

An aminopeptidase N that is encoded in the genome of pig.


AMPB_MOUSE Aminopeptidase B (sprot)

An aminopeptidase B that is encoded in the genome of mouse.


LCAP_RAT Leucyl-cystinyl aminopeptidase (sprot)

A leucyl-cystinyl aminopeptidase that is encoded in the genome of rat.


AMPB_RAT Aminopeptidase B (sprot)

An aminopeptidase B that is encoded in the genome of rat.


AMPL_BOVIN Cytosol aminopeptidase (sprot)


AMPN_MOUSE Aminopeptidase N (sprot)

An aminopeptidase N that is encoded in the genome of mouse.


AMPX_VIBPR Bacterial leucyl aminopeptidase (sprot)


AMPN_RAT Aminopeptidase N (sprot)

An aminopeptidase N that is encoded in the genome of rat.


PSA_HUMAN Puromycin-sensitive aminopeptidase (sprot)

A puromycin-sensitive aminopeptidase that is encoded in the genome of human.


ERAP1_HUMAN Endoplasmic reticulum aminopeptidase 1 (sprot)

An endoplasmic reticulum aminopeptidase 1 that is encoded in the genome of human.


PA21B_HUMAN Phospholipase A2 (sprot)

A phospholipase A2 that is encoded in the genome of human.


ENPP2_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (sprot)

An ectonucleotide pyrophosphatase/phosphodiesterase family member 2 that is encoded in the genome of human.


SSDH_HUMAN Succinate-semialdehyde dehydrogenase, mitochondrial (sprot)

A succinate-semialdehyde dehydrogenase, mitochondrial that is encoded in the genome of human.


UD15_HUMAN UDP-glucuronosyltransferase 1A5 (sprot)

A UDP-glucuronosyltransferase 1A5 that is encoded in the genome of human.


ALD1_RAT Aldo-keto reductase family 1 member B7 (sprot)

An aldo-keto reductase family 1 member B7 that is encoded in the genome of rat.


VANX_ENTFC D-alanyl-D-alanine dipeptidase (sprot)

A protein that is a translation product of any of the plasmid-encoded copies of the vanX gene in Enterococcus faecium.


MURG_ECOLI UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (sprot)

A UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase that is encoded in the genome of Escherichia coli K-12.


V2R_PIG Vasopressin V2 receptor (sprot)

A vasopressin V2 receptor that is encoded in the genome of pig.


V2R_BOVIN Vasopressin V2 receptor (sprot)

A vasopressin V2 receptor that is encoded in the genome of cow.


KCNC2_RAT Potassium voltage-gated channel subfamily C member 2 (sprot)

A voltage-gated potassium channel KCNC2 that is encoded in the genome of rat.


TPC1_HUMAN Two pore channel protein 1 (sprot)

A two pore channel protein 1 that is encoded in the genome of human.


TPC2_HUMAN Two pore channel protein 2 (sprot)

A two pore channel protein 2 that is encoded in the genome of human.


DGUOK_HUMAN Deoxyguanosine kinase, mitochondrial (sprot)

A deoxyguanosine kinase, mitochondrial that is encoded in the genome of human.


An adenosylhomocysteinase that is encoded in the genome of mouse.


GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial (sprot)

A 4-aminobutyrate aminotransferase, mitochondrial that is encoded in the genome of human.


GABT_RAT 4-aminobutyrate aminotransferase, mitochondrial (sprot)

A 4-aminobutyrate aminotransferase, mitochondrial that is encoded in the genome of rat.


GABT_MOUSE 4-aminobutyrate aminotransferase, mitochondrial (sprot)

A 4-aminobutyrate aminotransferase, mitochondrial that is encoded in the genome of mouse.


HCAR2_MOUSE Hydroxycarboxylic acid receptor 2 (sprot)

A hydroxycarboxylic acid receptor 2 that is encoded in the genome of mouse.


RDH12_HUMAN Retinol dehydrogenase 12 (sprot)

A retinol dehydrogenase 12 that is encoded in the genome of human.


RDH13_HUMAN Retinol dehydrogenase 13 (sprot)

A retinol dehydrogenase 13 that is encoded in the genome of human.


RET3_HUMAN Retinol-binding protein 3 (sprot)

A retinol-binding protein 3 that is encoded in the genome of human.


RET5_HUMAN Retinol-binding protein 5 (sprot)

A retinol-binding protein 5 that is encoded in the genome of human.


RET7_HUMAN Retinoid-binding protein 7 (sprot)

A retinoid-binding protein 7 that is encoded in the genome of human.


RET2_HUMAN Retinol-binding protein 2 (sprot)

A retinol-binding protein 2 that is encoded in the genome of human.


AL1A2_HUMAN Retinal dehydrogenase 2 (sprot)

A retinal dehydrogenase 2 that is encoded in the genome of human.


AL1A1_HUMAN Aldehyde dehydrogenase 1A1 (sprot)

An aldehyde dehydrogenase 1A1 that is encoded in the genome of human.


RLBP1_HUMAN Retinaldehyde-binding protein 1 (sprot)

A retinaldehyde-binding protein 1 that is encoded in the genome of human.


RET1_HUMAN Retinol-binding protein 1 (sprot)

A retinol-binding protein 1 that is encoded in the genome of human.


S19A2_HUMAN Thiamine transporter 1 (sprot)

A thiamine transporter 1 that is encoded in the genome of human.


TKT_HUMAN Transketolase (sprot)

A transketolase that is encoded in the genome of human.


TPK1_HUMAN Thiamin pyrophosphokinase 1 (sprot)

A thiamin pyrophosphokinase 1 that is encoded in the genome of human.


A thiamine-triphosphatase that is encoded in the genome of human.


TKTL1_HUMAN Transketolase-like protein 1 (sprot)

A transketolase-like protein 1 that is encoded in the genome of human.


THIT_LACLM Thiamine transporter ThiT (sprot)


BLVRB_HUMAN Flavin reductase (NADPH) (sprot)

A flavin reductase that is encoded in the genome of human.


RIFK_HUMAN Riboflavin kinase (sprot)

A riboflavin kinase that is encoded in the genome of human.


HCAR2_RAT Hydroxycarboxylic acid receptor 2 (sprot)

A hydroxycarboxylic acid receptor 2 that is encoded in the genome of rat.


PNPO_HUMAN Pyridoxine-5'-phosphate oxidase (sprot)

A pyridoxine-5'-phosphate oxidase that is encoded in the genome of human.


PLPP_HUMAN Chronophin (sprot)

A pyridoxal phosphate phosphatase that is encoded in the genome of human.


CBS_HUMAN Cystathionine beta-synthase (sprot)

A cystathionine beta-synthase that is encoded in the genome of human.


SERC_HUMAN Phosphoserine aminotransferase (sprot)

A phosphoserine aminotransferase that is encoded in the genome of human.


CP27A_HUMAN Sterol 26-hydroxylase, mitochondrial (sprot)

A cytochrome P450 27, mitochondrial that is encoded in the genome of human.


A0A2P2HJL8_ASPFA Sterol 14-alpha-demethylase (trembl)


G4WW85_ASPNG 14-alpha sterol demethylase (trembl)


Q9P8R0_ASPFM 14-alpha sterol demethylase (trembl)


VKORL_HUMAN Vitamin K epoxide reductase complex subunit 1-like protein 1 (sprot)

A vitamin K epoxide reductase complex subunit 1-like protein 1 that is encoded in the genome of human.


Xamoterol

A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.


FA7_HUMAN Coagulation factor VII (sprot)

A coagulation factor VII that is encoded in the genome of human.


FA11_HUMAN Coagulation factor XI (sprot)

A coagulation factor XI that is encoded in the genome of human.


NEUR3_HUMAN Sialidase-3 (sprot)

A sialidase-3 that is encoded in the genome of human.


NEUR2_HUMAN Sialidase-2 (sprot)

A sialidase-2 that is encoded in the genome of human.


NEUR4_HUMAN Sialidase-4 (sprot)

A sialidase-4 that is encoded in the genome of human.


KTHY_HUMAN Thymidylate kinase (sprot)

A thymidylate kinase that is encoded in the genome of human.


KITH_UREPA Thymidine kinase (sprot)

A thymidine kinase that is encoded in the genome of Ureaplasma parvum serovar 3 str. ATCC 700970.


Zimeldine

One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385)


ISPA_ECOLI Farnesyl diphosphate synthase (sprot)

A farnesyl diphosphate synthase that is encoded in the genome of Escherichia coli K-12.


GGPPS_YEAST Geranylgeranyl pyrophosphate synthase BTS1 (sprot)

A geranylgeranyl pyrophosphate synthase that is encoded in the genome of yeast.


AOF_DANRE Amine oxidase [flavin-containing] (sprot)

An amine oxidase [flavin-containing] B that is encoded in the genome of zebrafish.


AOFB_MOUSE Amine oxidase [flavin-containing] B (sprot)

An amine oxidase [flavin-containing] B that is encoded in the genome of mouse.


Kainic acid

(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.


LSHR_RAT Lutropin-choriogonadotropic hormone receptor (sprot)

A lutropin-choriogonadotropic hormone receptor that is encoded in the genome of rat.


Lypressin

The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.


P2RY6_HUMAN P2Y purinoceptor 6 (sprot)

A P2Y purinoceptor 6 that is encoded in the genome of human.


PFKA_TRYBB ATP-dependent 6-phosphofructokinase (sprot)


KPCL_HUMAN Protein kinase C eta type (sprot)

A protein kinase C eta type that is encoded in the genome of human.


KPCI_HUMAN Protein kinase C iota type (sprot)

A protein kinase C iota type that is encoded in the genome of human.


KPCZ_HUMAN Protein kinase C zeta type (sprot)

A protein kinase C zeta type that is encoded in the genome of human.


KPCG_HUMAN Protein kinase C gamma type (sprot)

A protein kinase C gamma type that is encoded in the genome of human.


KPCB_HUMAN Protein kinase C beta type (sprot)

A protein kinase C beta type that is encoded in the genome of human.


ENTP2_RAT Ectonucleoside triphosphate diphosphohydrolase 2 (sprot)

An ectonucleoside triphosphate diphosphohydrolase 2 that is encoded in the genome of rat.


P2RX3_RAT P2X purinoceptor 3 (sprot)

A P2X purinoceptor 3 that is encoded in the genome of rat.


P2RX1_RAT P2X purinoceptor 1 (sprot)

A P2X purinoceptor 1 that is encoded in the genome of rat.


STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta (sprot)

A signal transducer and activator of transcription 1 that is encoded in the genome of human.


STA5A_HUMAN Signal transducer and activator of transcription 5A (sprot)

A signal transducer and activator of transcription 5a that is encoded in the genome of human.


STA5B_HUMAN Signal transducer and activator of transcription 5B (sprot)

A signal transducer and activator of transcription 5b that is encoded in the genome of human.


Q4WLT4_ASPFU 1,3-beta-glucan synthase (trembl)


O13383_CANAX 1,3-beta-D-glucan synthase catalytic subunit (Fragment) (trembl)


GLR_HUMAN Glucagon receptor (sprot)

A glucagon receptor that is encoded in the genome of human.


GLR_RAT Glucagon receptor (sprot)

A glucagon receptor that is encoded in the genome of rat.


F8V479_MACFA Glucagon-like peptide 1 receptor (trembl)


GLP1R_MOUSE Glucagon-like peptide 1 receptor (sprot)

A glucagon-like peptide 1 receptor that is encoded in the genome of mouse.


Somatostatine

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.


SSR1_MOUSE Somatostatin receptor type 1 (sprot)

A somatostatin receptor type 1 that is encoded in the genome of mouse.


SSR4_MOUSE Somatostatin receptor type 4 (sprot)

A somatostatin receptor type 4 that is encoded in the genome of mouse.


SSR1_RAT Somatostatin receptor type 1 (sprot)

A somatostatin receptor type 1 that is encoded in the genome of rat.


SSR4_RAT Somatostatin receptor type 4 (sprot)

A somatostatin receptor type 4 that is encoded in the genome of rat.


O96529_MELIC Carboxylic ester hydrolase (trembl)


KISSR_HUMAN KiSS-1 receptor (sprot)

A KiSS-1 receptor that is encoded in the genome of human.


Bergapten

A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.

A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.


CP1A1_HUMAN Cytochrome P450 1A1 (sprot)

A cytochrome P450 1A1 that is encoded in the genome of human.


Bithionol

Halogenated anti-infective agent that is used against trematode and cestode infestations.

An aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, but withdrawn after being shown to be a potent photosensitizer with the potential to cause serious skin disorders.


Linoleic Acid

A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)

An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.


A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.

A pyrimidine 2'-deoxyribonucleoside compound having 5-bromouracil as the nucleobase.


Bufexamac

A benzeneacetamide with anti-inflammatory, analgesic, and antipyretic action. It is administered topically, orally, or rectally.

A hydroxamic acid derived from phenylacetamide in which the benzene moiety is substituted at C-4 by a butoxy group. It has anti-inflammatory, analgesic, and antipyretic properties.


SYYC_HUMAN Tyrosine--tRNA ligase, cytoplasmic (sprot)

A tyrosine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


NU1M_BOVIN NADH-ubiquinone oxidoreductase chain 1 (sprot)


TRPV1_MOUSE Transient receptor potential cation channel subfamily V member 1 (sprot)

A transient receptor potential cation channel TRPV1 that is encoded in the genome of mouse.


Carbaryl

A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.

A carbamate ester obtained by the formal condensation of  1-naphthol with methylcarbamic acid.


Q7YWJ9_MUSDO Carboxylic ester hydrolase (trembl)


K4JQ36_LAOST Carboxylic ester hydrolase (trembl)


Carbon Tetrachloride

A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)

A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.


CPSM_HUMAN Carbamoyl-phosphate synthase [ammonia], mitochondrial (sprot)

A carbamoyl-phosphate synthase [ammonia], mitochondrial that is encoded in the genome of human.


Cetrimonium

Cetyltrimethylammonium compound whose salts and derivatives are used primarily as topical antiseptics.

A quaternary ammonium ion in which the substituents on nitrogen are one hexadecyl and three methyl groups.


DYN1_HUMAN Dynamin-1 (sprot)

A dynamin-1 that is encoded in the genome of human.


CASP2_HUMAN Caspase-2 (sprot)

A caspase-2 that is encoded in the genome of human.


Cynarine

active principle of the artichoke; functions primarily as a cholagogue and choleretic and also as antilipemic agent

An alkyl caffeate ester obtained by the formal condensation of hydroxy groups at positions 1 and 3 of ()-quinic acid with two molecules of trans-caffeic acid.


Deaminooxytocin

octa-peptide lacking free amino group on cystine residue; RN given refers to cpd without isomeric designation


Desomorphine

an informal term for a cheap injectable illicit drug domestically prepared from codeine-containing medication in Russia


Diosmin

A bioflavonoid that strengthens vascular walls.

A disaccharide derivative that consists of  diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.


IKKB_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit beta (sprot)

An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of human.


Dioxadrol

See also records for d- and l-forms which are referred to as dexoxadrol and levoxadrol, respectfully


a nitrone benzene bissulfonate in development for stroke; has neuroprotective activity


TA2R_MOUSE Thromboxane A2 receptor (sprot)

A thromboxane A2 receptor that is encoded in the genome of mouse.


OXER1_HUMAN Oxoeicosanoid receptor 1 (sprot)

An oxoeicosanoid receptor 1 that is encoded in the genome of human.


Enilconazole

A racemate comprising equimolar amounts of (R)- and (S)-enilconazole. A fungicide used to control a wide range of fungi including Tilletia and Helminthosporium spp. on fruit, vegetables and ornamentals. In veterinary medicine, it is used topically for the treatment of fungal skin infections in cattle, dogs, and horses; it is also used by inhalation for the treatment of aspergillosis in ostriches.


Enoxolone

An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.

A pentacyclic triterpenoid that is olean-12-ene substituted by a hydroxy group at position 3, an oxo group at position 11 and a carboxy group at position 30.


DHI1_RAT 11-beta-hydroxysteroid dehydrogenase 1 (sprot)

An 11-beta-hydroxysteroid dehydrogenase 1 that is encoded in the genome of rat.


DHI2_RAT 11-beta-hydroxysteroid dehydrogenase type 2 (sprot)

An 11-beta-hydroxysteroid dehydrogenase type 2 that is encoded in the genome of rat.


LGUL_MOUSE Lactoylglutathione lyase (sprot)

A lactoylglutathione lyase that is encoded in the genome of mouse.


Ethacridine

A topically applied anti-infective agent.


GRIK4_RAT Glutamate receptor ionotropic, kainate 4 (sprot)

A glutamate receptor ionotropic, kainate 4 that is encoded in the genome of rat.


GRIK5_RAT Glutamate receptor ionotropic, kainate 5 (sprot)

A glutamate receptor ionotropic, kainate 5 that is encoded in the genome of rat.


Nordefrin

A norepinephrine derivative used as a vasoconstrictor agent.


EVANS BLUE

An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.


PTP1_YEAST Tyrosine-protein phosphatase 1 (sprot)

A protein that is a translation product of the PTP1 gene in yeast.


Sulindac sulfone

inhibits K-ras-dependent cyclooxygenase-2; sulfated analog of indomethacin;; CP248 is an antineoplastic agent that fosters microtubule depolymerization

A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps.  Lipoxygenase and Cox-2 inhibitor.


Femoxetine

serotonin uptake inhibitor; RN given refers to (3R-trans)-isomer


Fendosal

A benzoindole that is 4,5-dihydro-3H-benzo[e]indole in which the nitrogen is substituted by a 3-carboxy-4-hydroxyphenyl group. A non-narcotic analgesic and non-steroidal anti-inflammatory drug, it has greater analgesic and inflammatory responses than aspirin but with less gastrointestinal toxicity.


Fenticlor

An aryl sulfide having two 5-chloro-2-hydroxyphenyl groups attached to sulfur; an antiinfective drug mostly used in veterinary medicine.


UNG_VACCW Uracil-DNA glycosylase (sprot)


Fosfestrol

Rx of prostatic carcinoma; RN given refers to parent cpd with unspecified isomeric designation; structure


Fumagillin

empirical formula C25-27H34-37O7, a monoester of decatetraenedioic acid (HOOC-(C=CH)4-COOH and fumagillin (C16-17H25-26O3); FR 65814 lacks the fat

A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees.


Gabexate

A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.


KLKB1_HUMAN Plasma kallikrein (sprot)

A plasma kallikrein that is encoded in the genome of human.


2,5-Dihydroxybenzoic acid

A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.


Ibufenac

used in the treatment of rheumatism; also possesses antipyretic properties; minor descriptor (75-84); on-line & Index Medicus search PHENYLACETATES (75-84); RN given refers to parent cpd

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 4-isobutylphenyl group. Although it was shown to be effective in treatment of rheumatoid arthritis, the clinical use of ibufenac was discontinued due to hepatotoxic side-effects.


Isoconazole, (R)-

A racemate comprising equimolar amounts of (R)- and (S)-isoconazole. A broad-spectrum antibacterial drug used (as its nitrate salt) for treatment of dermatomycoses.


HCN1_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (sprot)

A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of human.


HCN2_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (sprot)

A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of human.


HCN3_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (sprot)

A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of human.


Khellin

A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)

A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.


FABP4_HUMAN Fatty acid-binding protein, adipocyte (sprot)

A fatty acid-binding protein, adipocyte that is encoded in the genome of human.


FABPH_HUMAN Fatty acid-binding protein, heart (sprot)

A fatty acid-binding protein, heart that is encoded in the genome of human.


FFAR4_HUMAN Free fatty acid receptor 4 (sprot)

A free fatty acid receptor 4 that is encoded in the genome of human.


Lubeluzole

a benzothiazole compound; used for the treatment of acute ischemic stroke; R-91154 is the inactive isomer


Mestanolone

non-virilizing androgenic steroid; RN given refers to (5alpha,17beta)-isomer; structure


Mesterolone

17 beta-Hydroxy-1 alpha-methyl-5 alpha-androstan-3-one. A synthetic steroid with anabolic and androgenic activities.


LUXS_BACSU S-ribosylhomocysteine lyase (sprot)


Mitoguazone

Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.

A hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine.


AOC1_RAT Amiloride-sensitive amine oxidase [copper-containing] (sprot)

An amiloride-sensitive amine oxidase [copper-containing] that is encoded in the genome of rat.


Nifenalol

adrenergic beta-blocker with good antiarrhythmic properties; also tends to lower blood pressure & provide protection against angina; minor descriptor (75-86); on-line & INDEX MEDICUS search ETHANOLAMINES (75-86); RN given refers to parent cpd without isomeric designation