Lymphomatous Adult T-Cell Leukemia/Lymphoma

An adult T-cell leukemia/lymphoma characterized by generalized lymphadenopathy without peripheral blood involvement.  Most patients have advanced disease, however hypercalcemia is not frequently present.


Pleomorphic Variant Mantle Cell Lymphoma

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

An aggressive mantle cell lymphoma characterized by the presence of pleomorphic neoplastic B-lymphocytes.


Burkitt's lymphoma of spleen

Burkitt lymphoma that involves the spleen.


Major Salivary Gland Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the parotid gland, submandibular gland, or sublingual gland.  Representative examples include mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


Ann Arbor Stage II Grade 3 Non-Contiguous Follicular Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Lymphoplasmacytoid lymphoma/immunocytoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Recurrent NK-Cell Lymphoma, Unclassifiable

The reemergence of NK-cell lymphoma, unclassifiable after a period of remission.


Diffuse large B-cell lymphoma, unclassifiable, NOS

A biologic subset of diffuse large B-cell lymphomas (DLBCL) that do not overexpress the genes whose overexpression characterizes the germinal center B-cell-like and activated B-cell-like DLBCL.  Morphologically, these lymphomas are either immunoblastic or centroblastic.  Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome, similar to those with an activated B-cell-like gene expression profile.


Recurrent Follicular T-Cell Lymphoma

The reemergence of follicular T-cell lymphoma after a period of remission.


Stage IVA2 Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IVA2 includes: T1-4, N3, M0, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


mycosis fungoides variant

A header term that includes the rare following variants of mycosis fungoides: folliculotropic mycosis fungoides, granulomatous slack skin disease, and pagetoid reticulosis.


Primary Bone Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement.  The femur, spine, and pelvic bones are the most frequently affected areas.  The majority of cases are diffuse large B-cell lymphomas.  Most patients present with pain in the affected area.  Systemic symptoms are rare.


Recurrent Primary Vitreoretinal Non-Hodgkin Lymphoma

The reemergence of primary vitreoretinal non-Hodgkin lymphoma after a period of remission.


Stage I Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage I includes: IA (T1, N0, M0, B0,1); IB (T2, N0, M0, B0,1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Methotrexate-Associated Peripheral T-Cell Lymphoma

A peripheral T-cell lymphoma that develops in patients who are immunosuppressed with methotrexate.


intravascular large B-cell lymphoma

Intravascular large B-cell lymphoma (IVLBCL) is a very rare form of diffuse large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of small blood vessels (especially the capillaries) that most often presents with a wide range of clinical manifestations (as potentially any tissue can be involved), with patients from Western countries more frequently manifesting with neurological and cutaneous symptoms while patients from Asian countries more frequently displaying hepatosplenomegaly and thrombocytopenia. IVLBCL is characterized by an absence of lymphadenopathy, an aggressive clinical course and a poor prognosis.


Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Diffuse large B-cell lymphoma, not otherwise specified that is resistant to treatment.


Refractory Lymphoblastic Lymphoma

Lymphoblastic lymphoma that is resistant to treatment.


Ann Arbor Stage II Grade 2 Non-Contiguous Follicular Lymphoma


Refractory Grade 3b Follicular Lymphoma

Grade 3b follicular lymphoma that is resistant to treatment.


Stage IV Adult Lymphoblastic Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Small Intestinal Monomorphic Epitheliotropic T-Cell Lymphoma

A monomorphic epitheliotropic intestinal T-cell lymphoma arising from the small intestine. It is characterized by the presence of a monomorphic cellular infiltrate of small to medium-sized T-lymphocytes that are cytotoxic and express CD56. It is not associated with celiac disease.


Methotrexate-Related Burkitt Lymphoma

A Burkitt lymphoma that develops in patients who are immunosuppressed with methotrexate.


Ann Arbor Stage II Grade 3 Contiguous Follicular Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Stage II Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage II includes: IIA (T1,2, N1,2, M0, B0,1); IIB (T3, N0-2, M0, B0,1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Recurrent Extranodal Diffuse Large B-cell Lymphoma

The reemergence of extranodal diffuse large B-cell lymphoma after a period of remission.


Nodal marginal zone B-cell lymphoma stage IV


Cutaneous Burkitt Lymphoma

Burkitt lymphoma that affects the skin.


large B-cell diffuse lymphoma of heart

A diffuse large B-cell lymphoma that arises from the heart.


large B-cell diffuse lymphoma of accessory sinus

A non-Hodgkin lymphoma that arises from the paranasal sinus and is characterized by the presence of a diffuse malignant infiltrate composed of large B-lymphocytes.


Ann Arbor Stage III Grade 2 Follicular Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IIA includes:  T1-2, N1,2, M0, B0,1. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Digestive System Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site.


Ann Arbor Stage II Contiguous Adult Lymphoblastic Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Non-Hodgkin's lymphoma transformed recurrent

The reemergence of non-Hodgkin lymphoma transformed after a period of remission.


Recurrent Anaplastic Large Cell Lymphoma

The reemergence of anaplastic large cell lymphoma after a period of remission.


Marginal zone lymphoma stage II

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (PDQ)


Esophageal Diffuse Large B-Cell Lymphoma

An extranodal diffuse large B-cell lymphoma that arises from the esophagus with the bulk of the mass located in the esophagus.


Angioimmunoblastic T-cell lymphoma refractory

Angioimmunoblastic T-cell lymphoma resistant to treatment.


Refractory Indolent Adult Non-Hodgkin Lymphoma

Indolent adult non-Hodgkin lymphoma that is resistant to treatment.


Childhood Lymphoblastic Lymphoma

A lymphoblastic lymphoma occurring in children.


A follicular lymphoma that develops in patients who are immunosuppressed with methotrexate.


Recurrent High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements

The reemergence of high grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements after a period of remission.


Stage IVB Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IVB includes: T1-4, N0-3, M1, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


Advanced Unfavorable Non-Hodgkin Lymphoma

A clinical stage II or IV non-Hodgkin lymphoma with at least four of the following risk factors: albumin level less than 4.0 g/dl, hemoglobin level of less than 10.5 g/dl, male sex, forty-five years of age or older, stage IV disease, white cell count of at least 15,000 per cubic millimeter, absolute lymphocytic count of less than 600 per cubic millimeter or a lymphocytic count of less than 8% of the total white cell count.


Recurrent High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements

The reemergence of high grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements after a period of remission.


Cutaneous Adult T-Cell Leukemia/Lymphoma

Adult T-cell leukemia/lymphoma affecting the skin.


Recurrent Plasmablastic Lymphoma

The reemergence of plasmablastic lymphoma after a period of remission.


primary mediastinal large B-cell lymphoma

A large B-cell non-Hodgkin lymphoma arising in the mediastinum. Morphologically it is characterized by a massive diffuse lymphocytic proliferation associated with compartmentalizing fibrosis. Response to intensive chemotherapy, with or without radiotherapy, is usually good. (WHO, 2001)


Stage I Childhood Anaplastic Large Cell Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Endometrial Mucosa-Associated Lymphoid Tissue Lymphoma

A rare extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue affecting the endometrium.


NK-Cell Lymphoma, Unclassifiable

A very rare NK-cell lymphoma with pathologic and clinical features posing difficulty in its exact diagnosis and classification.


Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Positive

An anaplastic large cell lymphoma, ALK-positive, arising from the central nervous system.


large B-cell diffuse lymphoma of nasal cavity

A non-Hodgkin lymphoma that arises from the nasal cavity and is characterized by the presence of a diffuse malignant infiltrate composed of large B-lymphocytes.


St. Jude Stage IV Childhood Non-Hodgkin Lymphoma AJCC v8

Stage IV: Any tumor, with initial CNS and/or bone marrow involvement. (from AJCC 8th Ed.)


St. Jude Childhood Non-Hodgkin Lymphoma by AJCC v8 Stage

A staging system for childhood non-Hodgkin Lymphomas based on the St. Jude Children's Research Hospital staging system. The Ann Arbor staging system has been found to be inappropriate for staging of the non-Hodgkin lymphomas of childhood. The St. Jude staging system has been widely accepted for more than three decades and remains the recommended staging system for childhood non-Hodgkin lymphomas. (from AJCC 8th Ed.)


Marginal zone lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Recurrent Adult Grade III Lymphomatoid Granulomatosis

The reemergence of grade III lymphomatoid granulomatosis in adulthood after a period of remission.


mediastinal gray zone lymphoma

A mediastinal lymphoma with molecular, morphologic, immunophenotypic, and clinical features of both mediastinal (thymic) large B-cell lymphoma and classical Hodgkin lymphoma. The identification of this group of lymphomas, along with recent gene expression profiling results (PDL2 gene expression in both mediastinal (thymic) large B-cell lymphoma tissues and Hodgkin lymphoma cell lines), further supports the hypothesis that mediastinal (thymic) large B-cell lymphomas and classical Hodgkin lymphomas are related entities.


Recurrent Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

The reemergence of diffuse large B-cell lymphoma that resulted from the transformation of indolent B-cell non-Hodgkin lymphoma, after a period of remission.


Ann Arbor Stage III Nodular Lymphocyte Predominant Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Refractory Extranodal Diffuse Large B-cell Lymphoma

Extranodal diffuse large B-cell lymphoma that is resistant to treatment.


Ann Arbor Stage II Childhood Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Refractory Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma that resulted from the transformation of indolent B-cell non-Hodgkin lymphoma and is resistant to treatment.


Refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

Monomorphic epitheliotropic intestinal T-cell lymphoma that is resistant to treatment.


Adult Grade III Lymphomatoid Granulomatosis

Grade III lymphomatoid granulomatosis that occurs in adulthood.


Intestinal T-cell lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Non-Hodgkin Lymphoma with Variable Clinical Course

A non-Hodgkin lymphoma with variable clinical course.


Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma

The reemergence of an aggressive B-cell non-Hodgkin lymphoma after a period of remission.


Peritoneal Primary Effusion Lymphoma

Primary effusion lymphoma that affects the peritoneal cavity. The majority of patients are HIV-positive men.


T-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for T-cell non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Sezary syndrome

Sezary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sezary cells).


Non-Hodgkin's lymphoma of prostate

A rare non-Hodgkin lymphoma that arises from the prostate gland.


Lymphoma, Small Cleaved-Cell, Follicular

A follicular lymphoma which contains up to 5 centroblasts per 40X high-power microscopic field.


Noncutaneous Childhood Anaplastic Large Cell Lymphoma by Ann Arbor Stage

An anatomic stage for noncutaneous childhood anaplastic large cell lymphoma based on the Ann Arbor classification criteria.


Advanced Favorable Non-Hodgkin Lymphoma

A clinical stage II or IV non-Hodgkin lymphoma with up to three of the following risk factors: albumin level less than 4.0 g/dl, hemoglobin level of less than 10.5 g/dl, male sex, forty-five years of age or older, stage IV disease, white cell count of at least 15,000 per cubic millimeter, absolute lymphocytic count of less than 600 per cubic millimeter or a lymphocytic count of less than 8% of the total white cell count.


Large B-cell lymphoma with IRF4 rearrangement

A large B-cell lymphoma typically affecting the Waldeyer ring and/or cervical lymph nodes. It occurs most commonly in children and young adults and is low stage. It is characterized by a follicular, follicular and diffuse, or pure diffuse growth pattern resembling follicular lymphoma grade 3B or a diffuse large B-cell lymphoma. Most cases have IG/IRF4 rearrangements. BCL2 rearrangements are not present. Some cases that belong in this category lack an IRF4 rearrangement but have strong IRF4/MUM1 expression. This lymphoma is more aggressive than pediatric-type follicular lymphomas.


Angiocentric lymphoma recurrent

The reemergence of nasal type extranodal NK/T-cell lymphoma after a period of remission.


Stage IV Anaplastic Large Cell Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Refractory Immunoblastic Lymphoma

Immunoblastic lymphoma that is resistant to treatment.


Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

Histologic transformation of a follicular lymphoma to an aggressive diffuse large B-cell lymphoma.


Classical Burkitt Lymphoma

A Burkitt lymphoma characterized by the presence of a uniform malignant lymphocytic infiltrate that is composed of medium-sized cells with round nuclei and multiple basophilic nucleoli, abundant mitotic figures, and a starry-sky pattern due to the presence of multiple tangible body macrophages.


Precursor B-lymphoblastic lymphoma stage I


Splenic marginal zone lymphoma refractory

Splenic marginal zone lymphoma that is resistant to treatment.


N1 diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma that is categorized as N1 with high probability by the LymphGen algorithm. This is based on a combination of genetic features. Although N1 DLBCLs always have an activating mutation affecting NOTCH1, LymphGen can assign cases with this mutation to other classes, depending on the presence of other genetic features.


Immunoblastic lymphoma associated with AIDS

A morphologic variant of diffuse large B-cell lymphoma occurring in HIV-positive patients.


Secondary Choroidal Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that has spread to the choroid following the initial presentation in another nodal or extranodal site.


Stage III Burkitt Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Refractory Follicular Lymphoma

Follicular lymphoma grade I, II, III that is resistant to treatment.


Recurrent Follicular Lymphoma

The reemergence of follicular lymphoma after a period of remission.


lymphoplasmacytic lymphoma

A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma cells involving the bone marrow, lymph nodes, and the spleen. The majority of patients have a serum IgM paraprotein.


T-cell lymphoma recurrent

The reemergence of T-cell non-Hodgkin lymphoma after a period of remission.


Lugano Classification Adult Non-Hodgkin Lymphoma by AJCC v8 Stage

A staging system for adult non-Hodgkin lymphomas based on the Lugano classification criteria. This staging system does not apply to ocular adnexal lymphomas (are staged according to the classification for ocular adnexal lymphoma), pediatric non-Hodgkin lymphomas (are staged according to the St. Jude Children's Research Hospital staging system), primary cutaneous lymphomas (are staged according to the classification for primary cutaneous lymphoma), and multiple myelomas (are staged according to the classification for plasma cell myeloma). (from AJCC 8th Ed.)


Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


Lacrimal Drainage System Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that arises from the lacrimal sac.


aggressive B-cell non-Hodgkin lymphoma

A B-cell non-Hodgkin lymphoma with an aggressive clinical course. This category includes B lymphoblastic lymphoma, subtypes of diffuse large B-cell lymphoma, Burkitt lymphoma, grade 3 follicular lymphoma, and mantle cell lymphoma.


Recurrent Intravascular Large B-Cell Lymphoma

The reemergence of intravascular large B-cell lymphoma after a period of remission.


Mycosis fungoides/Sezary syndrome stage IV

Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative.  M0: No visceral organ involvement.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified).  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.  (AJCC 7th ed.)


Parotid Gland Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that manifests initially in the parotid gland.


Lugano Classification Stage I Adult Non-Hodgkin Lymphoma AJCC v8

Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Gastric T-Cell Non-Hodgkin Lymphoma

A rare, extranodal T-cell non-Hodgkin lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


Advanced Marginal Zone Lymphoma

Marginal zone lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


childhood nasal type extranodal NK/T-cell lymphoma

A nasal type extranodal NK/T-cell lymphoma occurring in childhood.


Advanced Transformed Non-Hodgkin Lymphoma

Transformed non-Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Primary Cutaneous Intravascular Large B-Cell Lymphoma

Intravascular large B-cell lymphoma that arises from the skin.


B-cell lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Recurrent Peripheral T-Cell Lymphoma, Not Otherwise Specified

The reemergence of peripheral T-cell lymphoma, not otherwise specified after a period of remission.


Nodal marginal zone B-cell lymphoma recurrent

The reemergence of nodal marginal zone lymphoma after a period of remission.


Campylobacter Jejuni-Associated Small Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma

A mucosa-associated lymphoid tissue lymphoma that arises from the small intestine and it is associated with Campylobacter jejuni infection.


Centroblastic lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Esophageal Mucosa-Associated Lymphoid Tissue Lymphoma

An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the esophagus with the bulk of the mass located in the esophagus.


Recurrent Grade 3a Follicular Lymphoma

The reemergence of grade 3a follicular lymphoma after a period of remission.


Sporadic Burkitt's lymphoma

A clinical variant of Burkitt lymphoma that occurs throughout the world.  It affects both children and adults and is more frequently seen in males.


Extranodal marginal zone B-cell lymphoma (MALT type) stage I

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage I disease.


Adult T-cell lymphoma/leukemia stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Pituitary Gland Diffuse Large B-Cell Lymphoma

A rare diffuse large B-cell lymphoma that arises from the pituitary gland.


Recurrent Childhood Anaplastic Large Cell Lymphoma

The reemergence of anaplastic large cell lymphoma in childhood after a period of remission.


Precursor B-lymphoblastic lymphoma refractory

B-lymphoblastic lymphoma that does not respond to treatment.


Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma

An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the ocular adnexa. It is the most common type of primary ocular adnexal lymphoma.


Anaplastic large B-cell lymphoma

A diffuse large B-cell lymphoma variant characterized by the presence of large round, oval, or polygonal cells with bizarre pleomorphic nuclei resembling Hodgkin or Reed-Sternberg cells. It is unrelated to anaplastic large cell lymphoma which is a T-cell non-Hodgkin lymphoma.


Stage III Childhood Lymphoblastic Lymphoma

Stage III: Tumors or involved lymph node areas occur on both sides of the diaphragm. Stage III also includes any primary intrathoracic (mediastinal, pleural, or thymic) disease, extensive primary intra-abdominal disease, or any paraspinal or epidural tumors (from PDQ).


Ann Arbor Stage IV Nodular Lymphocyte Predominant Hodgkin Lymphoma


Dural Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

A rare, primary marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the meningeal dura.  The majority of cases have been described in middle aged women.  Radiologically, the lymphomatous dural infiltration mimics meningioma.


Recurrent Indolent Non-Hodgkin Lymphoma

The reemergence of indolent non-Hodgkin lymphoma after a period of remission.


Adult Immunoblastic Lymphoma

A morphologic variant of diffuse large B-cell lymphoma occurring in adults.  It is characterized by the presence of large lymphoid cells with abundant cytoplasm and prominent nucleoli.


Stage II Adult Lymphoblastic Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Transformed Small Lymphocytic Lymphoma to Diffuse Large B-Cell Lymphoma

Histologic transformation of a small lymphocytic lymphoma to an aggressive diffuse large B-cell lymphoma.


B Lymphoblastic Lymphoma by Ann Arbor Stage

An anatomic stage for B-lymphoblastic lymphoma based on the Ann Arbor classification criteria.


Refractory Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

Primary vitreoretinal diffuse large B-cell lymphoma that does not respond to treatment.


intraocular lymphoma

A lymphoma that arises within the eye. Signs and symptoms include decreased vision, uveitis, and vitreous floaters.


Stage IIIB Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IIIB includes: T4, N0-2, M0, B1. T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Recurrent Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

The reemergence of primary diffuse large B-cell lymphoma of the central nervous system after a period of remission.


Ann Arbor Stage II Non-Contiguous Aggressive Adult Non-Hodgkin Lymphoma


Childhood Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that occurs during childhood.


Parotid Gland Mantle Cell Lymphoma

A mantle cell lymphoma that manifests initially in the parotid gland.


subcutaneous panniculitis-like T-cell lymphoma

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic cutaneous lymphoma that has been recognized as a distinct subset of peripheral T-cell lymphomas originating and presenting primarily in the subcutaneous fat tissue.


Recurrent Childhood Non-Hodgkin Lymphoma

The reemergence of non-Hodgkin lymphoma in childhood after a period of remission.


Refractory Central Nervous System Non-Hodgkin Lymphoma

A central nervous system non-Hodgkin lymphoma which does not respond to treatment.


Stage II Burkitt Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Stage II Childhood Anaplastic Large Cell Lymphoma


Refractory Hepatosplenic T-Cell Lymphoma

Hepatosplenic T-cell lymphoma that is resistant to treatment.


HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

A large B-cell lymphoma characterized by the presence of a diffuse proliferation of large, atypical HHV8-positive neoplastic lymphocytes. It usually arises in association with HHV8-positive multicentric Castleman disease.


Childhood Burkitt Lymphoma

A Burkitt lymphoma occurring in children.


Ann Arbor Stage IV Aggressive Adult Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Burkitt Lymphoma by Ann Arbor Stage

An anatomic stage for Burkitt lymphoma based on the Ann Arbor classification criteria.


Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

The reemergence of primary cutaneous diffuse large B-cell lymphoma, leg type after a period of remission.


Breast implant-associated anaplastic large cell lymphoma

A rare anaplastic large cell lymphoma that can develop following breast implants. It has been reported in patients with saline-and silicone-filled implants. It usually presents as an accumulation of seroma fluid between the implant and the surrounding fibrous capsule. The median interval from the time of the implant to the development of lymphoma is approximately 10 years.


Colorectal Non-Hodgkin Lymphoma

An extranodal non-Hodgkin lymphoma that arises from the colon or rectum.  The majority are B-cell non-Hodgkin lymphomas.


Esophageal Non-Hodgkin Lymphoma

An extranodal non-Hodgkin lymphoma that arises from the esophagus with the bulk of the mass located in the esophagus.  Dysphagia may be the presenting symptom.  The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue.


Childhood Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that occurs during childhood.


Extranodal marginal zone B-cell lymphoma (MALT type) recurrent

The reemergence of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue after a period of remission.


Intestinal Follicular Lymphoma

A follicular lymphoma arising from the intestine.  The majority of cases occur in the small intestine, particularly the duodenum.  Usually the patients have localized disease and a favorable clinical outcome.


Burkitt Lymphoma with Plasmacytoid Differentiation

Burkitt lymphoma characterized by the presence of malignant cells with eccentric basophilic cytoplasm. The nucleoli of these cells are often single and central. This morphologic variant of Burkitt lymphoma is more often seen in patients with immunodeficiency.


Angiocentric lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


non-Hodgkin's lymphoma of lacrimal gland

A non-Hodgkin lymphoma that arises from the lacrimal gland. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma.


Burkitt's lymphoma of breast

A Burkitt lymphoma that arises from the breast.  It usually affects pregnant or lactating women and presents with bilateral breast involvement and breast swelling.


B-cell small lymphocytic lymphoma refractory

B-cell small lymphocytic lymphoma that is resistant to treatment.


Ann Arbor Stage III Mature T- and NK-Cell Lymphoma


AIDS-Related Anal Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma arising from the anus and occurring in HIV-positive patients.  Homosexual HIV-positive men have an increased risk of developing anal non-Hodgkin lymphoma in comparison to the general male population.  The majority of the cases are large cell lymphomas of B-cell phenotype.


Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

T-cell/histiocyte-rich large B-cell lymphoma that is resistant to treatment.


Prostate Small Lymphocytic Lymphoma

A rare small lymphocytic lymphoma that arises from the prostate gland.


Recurrent Childhood Burkitt Lymphoma

The reemergence of Burkitt lymphoma in childhood after a period of remission.


Nasal Cavity Extranodal NK/T-Cell Lymphoma

An extranodal NK/T-cell lymphoma that arises from the nasal cavity.


Pyothorax-Associated Lymphoma

An aggressive diffuse large B-cell lymphoma arising in the pleural cavity of patients with a history of long standing pyothorax.  Patients present with chest and back pain, fever, productive cough, dyspnea, and hemoptysis.


Ann Arbor Stage I Grade 1 Follicular Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Recurrent Aggressive Non-Hodgkin Lymphoma

An aggressive non-Hodgkin lymphoma that has recurred after a period of remission.


non-Hodgkin's lymphoma of nasal cavity

A primary non-Hodgkin lymphoma that affects the nasal cavity and the bulk of the tumor is in this anatomic area.  The majority of the cases are nasal type extranodal NK/T-cell lymphomas and diffuse large B-cell lymphomas.


Adult T-cell lymphoma/leukemia stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Primary Choroidal Non-Hodgkin Lymphoma

An indolent, low-grade B-cell non-Hodgkin lymphoma that arises from the choroid. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Lymphoid follicles with germinal centers may be present. In the past these tumors were termed 'reactive lymphoid hyperplasia'. Now they are considered low-grade B-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

The reemergence of T-cell/histiocyte-rich large B-cell lymphoma after a period of remission.


Secondary Central Nervous System Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


Intestinal T-Cell Lymphoma, Not Otherwise Specified

A T-cell lymphoma arising in the intestines, or sometimes other sites in the gastrointestinal tract, that does not conform to either classic enteropathy-associated T-cell lymphoma or monomorphic epitheliotropic intestinal T-cell lymphoma. (WHO 2017)


Ann Arbor Stage II Mature T- and NK-Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


Refractory Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

Diffuse large B-cell lymphoma associated with chronic inflammation that is resistant to treatment.


Cerebral Lymphoma in Immunocompetent Host

A cerebral lymphoma that arises in an immunocompetent host.


diffuse large B-cell lymphoma activated B-cell type

A diffuse large B-cell lymphoma that is characterized by the expression of CD44, PKCbeta1, Cyclin D2, BCL-2, and IRF4/MUM1 genes.


Marginal zone lymphoma refractory

Marginal zone lymphoma which does not respond to treatment.


Cerebral Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises in the cerebral hemispheres as a primary lesion.


Ann Arbor Stage II Contiguous Adult Non-Hodgkin Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


primary cutaneous gamma-delta t-cell lymphoma

A primary cutaneous T-cell non-Hodgkin lymphoma that is characterized by the clonal cutaneous proliferation of activated mature gamma-delta T cells with a cytotoxic phenotype.


primary effusion lymphoma

Primary effusion lymphoma (PEL) is a large B-cell lymphoma located in the body cavities, characterized by pleural, peritoneal, and pericardial fluid lymphomatous effusions and that is always associated with human herpes virus-8 (HHV-8).


Adult Anaplastic Large Cell Lymphoma

An anaplastic large cell lymphoma occurring in adults.


Refractory Primary Effusion Lymphoma

Primary effusion lymphoma that is resistant to treatment.


Helicobacter Pylori-Related Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma that is caused by Helicobacter Pylori.


Refractory Grade 3 Follicular Lymphoma

Grade 3 follicular lymphoma that is resistant to treatment.


Early Unfavorable Non-Hodgkin Lymphoma

A clinical stage I or II non-Hodgkin lymphoma with at least one of the following risk factors: large mediastinal mass, extranodal spread, elevated erythrocyte sedimentation rate, involvement of at least three lymph node areas, and B symptoms.


Thyroid Non-Hodgkin's Lymphoma

A non-Hodgkin lymphoma primarily involving the thyroid gland.  The vast majority of cases are either diffuse large B-cell lymphomas or extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue. Hashimoto (chronic lymphocytic) thyroiditis is almost always present.


Grade 2 Cutaneous Follicular Lymphoma

A cutaneous lymphoma which contains 6-15 centroblasts per 40X high-power microscopic field.


Ann Arbor Stage III Grade 1 Follicular Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Fibrin-Associated Diffuse Large B-Cell Lymphoma

An unusual form of diffuse large B-cell lymphoma. It is not mass-forming and does not directly produce symptoms, but it is discovered incidentally on histological examination of surgical pathology specimens, excised for various pathologies other than lymphoma. The specimens typically contain fibrinous materials. Single and small aggregates of large lymphoma cells are found in only small foci within the fibrinous or amorphous material. EBV is positive, with type III latency. The clinical outcome is highly favorable, even with surgical excision alone. (WHO 2017)


Mycosis fungoides recurrent

The reemergence of mycosis fungoides after a period of remission.


Transformed B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

Histologic transformation of a B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma to an aggressive diffuse large B-cell lymphoma.


Anaplastic Large Cell Lymphoma, Sarcomatoid Subtype

A are variant of anaplastic large cell lymphoma. It is characterized by presence of large spindle shaped cells resembling a soft tissue sarcoma.


Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IIB includes: T3, N0-2, M0, B0,1. T3: One or more tumors (equal or greater than 1 cm in diameter). N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Childhood B Lymphoblastic Lymphoma

A B-lymphoblastic lymphoma that occurs during childhood.


Stage III Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage III includes: (T4, N0-2, M0, B0,1); IIIA (T4, N0-2, M0, B0); IIIB (T4, N0-2, M0, B1). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Primary mediastinal large B-cell lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Non-hodgkin lymphoma of colon

An extranodal non-Hodgkin lymphoma that arises from the colon.  The majority are B-cell non-Hodgkin lymphomas.


Ann Arbor Stage II Contiguous Adult Burkitt Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Angioimmunoblastic T-cell lymphoma recurrent

The reemergence of angioimmunoblastic T-cell lymphoma after a period of remission


Recurrent Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

The reemergence of primary vitreoretinal diffuse large B-cell lymphoma after a period of remission.


non-Hodgkin's lymphoma of small intestine

A B-cell or T-cell non-Hodgkin lymphoma that arises from the small intestine.  Representative examples of B-cell non-Hodgkin lymphoma include diffuse large B-cell lymphoma, MALT lymphoma, alpha heavy chain disease/immunoproliferative small intestinal disease, Burkitt lymphoma, follicular lymphoma, and mantle cell lymphoma.  The T-cell non-Hodgkin lymphomas are the enteropathy-associated T-cell lymphoma and the monomorphic CD56 positive intestinal T-cell lymphoma.


Childhood Grade III Lymphomatoid Granulomatosis

Grade III lymphomatoid granulomatosis that occurs during childhood.


Stage II Childhood Burkitt Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Primary Cutaneous Plasmablastic Lymphoma

Plasmablastic lymphoma that arises from the skin.


Primary Bone Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that arises from the bone, without lymph node or other extranodal involvement.


Refractory Mature B-Cell Non-Hodgkin Lymphoma

Mature B-cell non-Hodgkin lymphoma that does not respond to treatment.


Angiocentric lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Centroblastic Lymphoma by Ann Arbor Stage

An anatomic stage for centroblastic lymphoma based on the Ann Arbor classification criteria.


B Lymphoblastic Lymphoma

An uncommon type of lymphoma.  It constitutes approximately 10% of cases of lymphoblastic lymphoma.  Approximately 75% of cases reported in a literature review involved patients who were less than 18 years of age.  The most commonly affected sites are the skin, bone, soft tissue, and lymph nodes.  It has a high remission rate with a median survival of approximately 60 months.  (WHO, 2001)


Central Nervous System B-Cell Non-Hodgkin Lymphoma

A B-cell non-Hodgkin lymphoma that arises from the brain, meninges, or spinal cord.


Thymic Mucosa-Associated Lymphoid Tissue Lymphoma

A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that affects the thymus.  It is characterized by the presence of centrocyte-like or monocytoid lymphocytes that surround reactive lymphoid follicles.  There is infiltration of the thymic epithelium by lymphocytes and formation of lymphoepithelial lesions.  It is associated with the presence of autoimmune disease, most frequently Sjogren syndrome. Patients are usually asymptomatic and the tumor is detected incidentally as a mediastinal mass on chest x-ray.  A minority of patients present with dyspnea, hemoptysis, and chest pain.  The prognosis is excellent.


Conjunctival Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the conjunctiva.


Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

The reemergence of diffuse large B-cell lymphoma germinal center B-cell type after a period of remission.


Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Involving the Digestive System

An extranodal low-grade B-cell non-Hodgkin lymphoma arising in mucosal or glandular tissues of the digestive system. It recapitulates the cytoarchitectural features of mucosa-associated lymphoid tissue (MALT). It is composed of small lymphoid cells, often including marginal zone cells. (WHO 2019)


Precursor B-lymphoblastic lymphoma recurrent

The reemergence of B-lymphoblastic lymphoma after a period of remission.


Digestive System Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that arises from the digestive system.


Nodal Marginal Zone Lymphoma by Ann Arbor Stage

An anatomic stage for nodal marginal zone lymphoma based on the Ann Arbor classification criteria.


St. Jude Stage II Childhood Non-Hodgkin Lymphoma AJCC v8

Stage II: A single tumor (extranodal) with regional node involvement. Two or more nodal areas on the same side of the diaphragm. Two single (extranodal) tumors with or without regional node involvement on the same side of the diaphragm. A primary gastrointestinal tract tumor, usually in the ileocecal area, with or without involvement of associated mesenteric nodes only. (from AJCC 8th Ed.)


Marginal Zone Lymphoma by Ann Arbor Stage

An anatomic stage for marginal zone lymphoma based on the Ann Arbor classification criteria.


Mycosis fungoides/Sezary syndrome refractory

Mycosis fungoides and Sezary syndrome that is resistant to treatment.


AIDS-Related Burkitt Lymphoma with Plasmacytoid Differentiation

A Burkitt lymphoma with plasmacytoid differentiation occurring in HIV-positive patients.


Diffuse Blastoid B-Cell Lymphoma

A distinct subtype of high-grade follicular center cell lymphoma, representing a diffuse transformation of conventional follicular lymphoma.  Although this type of lymphoma strongly expresses BCL-2, it does not carry the characteristic t(14;18)(q32;q21) chromosomal translocation found in follicular lymphomas.  Instead, extra copies of chromosome 18 are often detected.


Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

The reemergence of primary cutaneous T-cell non-Hodgkin lymphoma after a period of remission.


Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

Diffuse large B-cell lymphoma germinal center B-cell type that is resistant to treatment.


Intestinal T-cell lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Burkitt-like lymphoma with 11q aberration

A molecularly distinct B-cell lymphoma reminiscent of Burkitt lymphoma. It is characterized by the absence of MYC translocation and the presence of chromosome 11q aberrations.


Adult Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma occurring in adults.


Lymphohistiocytic Variant Anaplastic Large Cell Lymphoma

A histologic variant of anaplastic large cell lymphoma characterized by the presence of a large number of histiocytes admixed with the anaplastic lymphoma cells.


Thyroid Immunoblastic Lymphoma

A diffuse large B-cell lymphoma variant, primarily involving the thyroid gland.  It is composed predominantly of immunoblasts.


Recurrent Transformed T-cell Non-Hodgkin Lymphoma

The reemergence of T-cell non-Hodgkin lymphoma transformed after a period of remission.


Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly is a rare form of diffuse large B-cell lymphoma occurring most commonly in patients over the age of 50 (usually between 70-75 years of age), without overt immunodeficiency, and presenting with nodal and extranodal involvement (in sites such as the stomach, lung, skin and pancreas) and B symptoms (fever, night sweats, weight loss). The tumor is characterized by an aggressive course and a short survival rate.


Lymphoma, Large-Cell, Follicular

A follicular lymphoma which contains more than 15 centroblasts per 40X high-power microscopic field.


Adult T-cell lymphoma/leukemia refractory

Adult T-cell leukemia/lymphoma that is resistant to treatment.


Refractory High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements

High grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements that is resistant to treatment.


B-cell small lymphocytic lymphoma recurrent

The reemergence of small lymphocytic lymphoma after a period of remission.


Extracavitary Primary Effusion Lymphoma

A rare HHV8-positive B-cell lymphoma indistinguishable from primary effusion lymphoma presenting as solid tumor mass. (WHO 2017)


Stage II Indolent Adult Non-Hodgkin Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Stage IV Adult Immunoblastic Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Aggressive Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma with an aggressive clinical course.  Representative examples include Burkitt lymphoma, mantle cell lymphoma, and angioimmunoblastic T-cell lymphoma.


Parotid Gland Mucosa-Associated Lymphoid Tissue Lymphoma

A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue arising from the parotid gland. It is the most common type of non-Hodgkin lymphoma in the parotid gland and is often associated with Sjogren syndrome. The prognosis is favorable.


follicular lymphoma of salivary gland

A follicular lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland.


ST2 Diffuse Large B-Cell Lymphoma

A genetic subtype of diffuse large B-cell lymphoma characterized by SGK1 and TET2 gene mutations.


non-Hodgkin's lymphoma of salivary gland

A non-Hodgkin lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland. Mucosa-associated lymphoid tissue lymphoma is the most common primary salivary gland non-Hodgkin lymphoma.


Recurrent EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

The reemergence of EBV-positive diffuse large B-cell lymphoma, not otherwise specified after a period of remission.


Ann Arbor Stage II Grade 1 Non-Contiguous Follicular Lymphoma


Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IIA includes: T1-2, N1-2, M0, B0-1.  T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Non-Hodgkin's lymphoma refractory

A non-Hodgkin lymphoma which does not respond to treatment.


follicular lymphoma of lacrimal gland

A follicular lymphoma that arises from the lacrimal gland.


Stage IA Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IA includes: T1, N0, M0, B0-1.  T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Sinonasal Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the sinonasal tract.


Ann Arbor Stage II Adult Non-Contiguous Immunoblastic Lymphoma


Angiocentric lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Immunoblastic Lymphoma Post-Transplant Lymphoproliferative Disorder

An immunoblastic lymphoma that arises in a patient with a history of organ transplantation.


Lugano Classification Stage III Adult Non-Hodgkin Lymphoma AJCC v8

Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Recurrent Indolent T-Cell Non-Hodgkin Lymphoma

The reemergence of indolent T-cell non-Hodgkin lymphoma after a period of remission.


Stage III Anaplastic Large Cell Lymphoma

Ann Arbor Classification. Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Stage II Adult Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


Nodal marginal zone B-cell lymphoma refractory

Nodal marginal zone B-cell lymphoma resistant to treatment.


Primary EBV-Positive Nodal T-Cell or NK-Cell Lymphoma

An EBV-positive peripheral T-cell lymphoma that arises from the lymph nodes. It is characterized by a monomorphic pattern of infiltration and abscence of the angiodestruction and necrosis seen in extranodal NK/T-cell lymphomas. These lymphomas are more common in elderly patient, or in the setting of immune deficiency. For the time being, they are considered a variant of peripheral T-cell lymphoma, not otherwise specified. (WHO 2017)


Malignant lymphoma centroblastic, diffuse

A B-cell non-Hodgkin lymphoma composed of large noncleaved cells. This is a subtype of diffuse large B-cell non-Hodgkin lymphoma.


Recurrent Indolent B-Cell Non-Hodgkin Lymphoma

The reemergence of indolent B-cell non-Hodgkin lymphoma after a period of remission.


B-cell small lymphocytic lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

The reemergence of mature T-cell and NK-cell non-Hodgkin lymphoma after a period of remission.


Refractory Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma that resulted from the transformation of marginal zone lymphoma and is resistant to treatment.


Angioimmunoblastic T-cell lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Early Favorable Non-Hodgkin Lymphoma

A clinical stage I or II non-Hodgkin lymphoma without any of the following risk factors: large mediastinal mass, extranodal spread, elevated erythrocyte sedimentation rate, involvement of at least three lymph node areas, and B symptoms.


Mycosis fungoides stage II

Stage II includes: IIA (T1-2, N1-2, M0, B0-1); IIB (T3, N0-2, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Ann Arbor Stage I Subdiaphragmatic Nodular Lymphocyte Predominant Hodgkin Lymphoma


Refractory Grade 2 Follicular Lymphoma

Grade 2 follicular lymphoma that is resistant to treatment.


Leukemic Phase of Non-Hodgkin's Lymphoma

A usually terminal event in the clinical course of lymphomas.  The term indicates the presence of atypical, clonal (malignant) lymphocytes (lymphoma cells) in the peripheral blood.


Refractory Aggressive Non-Hodgkin Lymphoma

An aggressive non-Hodgkin lymphoma that is resistant to treatment.


Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes

Molecular subtyping of diffuse large B-cell lymphomas (DLBCL) based on structural genomic abnormalities and gene expression data obtained from biopsy samples. The molecular analysis revealed four subtypes of DLBCL (MCD, BN2, N1, and EZB) which have distinct genotypic, epigenetic, and clinical characteristics. (NEJM 2018; 378: 1396-407)


Lugano Classification Limited Stage Adult Non-Hodgkin Lymphoma AJCC v8

Limited stage adult non-Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Adult T-cell lymphoma/leukemia stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Splenic Small Lymphocytic Lymphoma

Small lymphocytic lymphoma occurring in the spleen.


diffuse large B-cell lymphoma of the central nervous system

A diffuse large B-cell lymphoma arising from the central nervous system.


Follicular T-cell lymphoma

A lymph node-based peripheral T-cell lymphoma of T-follicular helper (TFH) cells, with a predominantly follicular growth pattern. It lacks characteristic features of angioimmunoblastic T-cell lymphoma such as proliferation of high endothelial venules or extrafollicular follicular dendritic cells. (WHO 2017)


Pharyngeal Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the pharynx.


Splenic Lymphoplasmacytic Lymphoma

A lymphoplasmacytic lymphoma  occurring in the spleen.


Refractory Breast Implant-Associated Anaplastic Large Cell Lymphoma

Breast implant-associated anaplastic large cell lymphoma that is resistant to treatment.


non-Hodgkin's lymphoma of liver

A rare non-Hodgkin lymphoma that arises from the liver and the bulk of the tumor is located in the liver.  The most frequent types of non-Hodgkin lymphoma that arise from the liver are diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma.


Mantle cell lymphoma refractory

Mantle cell lymphoma resistant to treatment.


AIDS-Related Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that develops in a patient with AIDS.


Primary Mediastinal (Thymic) Large B-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for mediastinal (thymic) large B-cell lymphoma based on the Ann Arbor classification criteria.


Stage II Diffuse Large B-Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Adult Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma occurring in adults.


ALK-positive large B-cell lymphoma

Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma is a very rare variant of diffuse large B-cell lymphoma (DLBCL) mainly affecting middle-aged immunocompetent men and characterized by a consistent primary involvement of lymph nodes (mainly in the cervical and mediastinum lymph nodes) and with infrequent extra nodal involvement of the bone marrow and other extra-nodal sites (head and neck region, liver, spleen, and gastrointestinal tract). It has an aggressive disease course, and is associated with a poor prognosis.


Lugano Classification Stage IE Adult Non-Hodgkin Lymphoma AJCC v8

Stage IE: Single extralymphatic site in the absence of nodal involvement. (from AJCC 8th Ed.)


peripheral T-cell lymphoma, not otherwise specified

Aggressive nodal or extranodal mature (peripheral) T-cell lymphomas that do not belong to the better defined entities of the remainder of mature T-cell lymphomas. This category includes the following variants: lymphoepithelioid cell variant (Lennert's lymphoma), follicular variant, and T-zone variant.


Recurrent Grade 1 Follicular Lymphoma

The reemergence of grade 1 follicular lymphoma after a period of remission.


Stage I Childhood Lymphoblastic Lymphoma

Stage I: A single tumor or nodal area is involved, excluding the abdomen and mediastinum (from PDQ).


Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IB includes: T2, N0, M0, B0-1. T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Anaplastic Large Cell Lymphoma, Signet Ring-Like Subtype

An anaplastic large cell lymphoma, characterized by lymphoid cells with signet ring nuclei.


Extranodal marginal zone B-cell lymphoma (MALT type) stage III

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage III disease.


Recurrent Central Nervous System Non-Hodgkin Lymphoma

The reemergence of central nervous system non-Hodgkin lymphoma after a period of remission.


ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) is a type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the expression of a protein called anaplastic lymphoma kinase (ALK).


Mycosis fungoides/Sezary syndrome recurrent

The reemergence of mycosis fungoides/Sezary syndrome after a period of remission.


Recurrent Adult Lymphoblastic Lymphoma

The reemergence of adult lymphoblastic lymphoma after a period of remission.


Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

Histologic transformation of an indolent B-cell non-Hodgkin lymphoma to an aggressive diffuse large B-cell lymphoma.


Adult Primary Cutaneous Anaplastic Large Cell Lymphoma

Primary cutaneous anaplastic large cell lymphoma that occurs in adults.


Aggressive T-Cell Non-Hodgkin Lymphoma

A T-cell non-Hodgkin lymphoma with an aggressive clinical course. This category includes T lymphoblastic lymphoma, anaplastic large cell lymphoma, ALK-negative, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, intestinal T-cell lymphoma, nasal type extranodal NK/T-cell lymphoma, peripheral T-cell lymphoma, not otherwise specified, and subtypes of primary cutaneous T-cell non-Hodgkin lymphoma.


Recurrent Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

The reemergence of primary systemic anaplastic large cell lymphoma, ALK-positive after a period of remission.


Recurrent Mature B-Cell Non-Hodgkin Lymphoma

The reemergence of mature B-cell non-Hodgkin lymphoma after a period of remission.


Lacrimal System Mucosa-Associated Lymphoid Tissue Lymphoma

A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal gland or the lacrimal drainage system.


Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Primary cutaneous diffuse large B-cell lymphoma, leg type that is resistant to treatment.


Grade 3 Cutaneous Follicular Lymphoma

A cutaneous lymphoma which contains more than 15 centroblasts per 40X high-power microscopic field.


Gastric Burkitt Lymphoma

An extranodal Burkitt lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


Recurrent Non-Hodgkin Lymphoma

The reemergence of non-Hodgkin lymphoma after a period of remission.


Small Lymphocytic Lymphoma by Ann Arbor Stage

An anatomic stage for small lymphocytic lymphoma based on the Ann Arbor classification criteria.


High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

A rare B-cell non-Hodgkin lymphoma that is characterized by the abnormal rearrangement of MYC gene, BCL2 gene, and/or BCL6 gene. Patients with this type of lymphoma usually respond poorly to standard treatments and have a poor prognosis.


Diffuse large B-cell lymphoma associated with chronic inflammation

A diffuse large B-cell lymphoma arising in body cavities or narrow spaces of long standing chronic inflammation.  The classic example is the pyothorax-associated lymphoma that arises in the pleural cavity of patients with a history of long standing pyothorax.


Primary mediastinal large B-cell lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


gastric diffuse large B-cell lymphoma

An extranodal diffuse large B-cell lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


Non-Hodgkin Lymphoma During Pregnancy

Non-Hodgkin lymphoma that occurs during pregnancy.


Recurrent Primary Effusion Lymphoma

The reemergence of primary effusion lymphoma after a period of remission.


Enteropathy-Associated T-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for enteropathy-associated T-cell lymphoma based on the Ann Arbor classification criteria.


Childhood Non-Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for childhood non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Tonsillar Mantle Cell Lymphoma

A rare mantle cell lymphoma that affects the tonsil and the bulk of the tumor is in this anatomic area.


Ann Arbor Stage IV Grade 3 Follicular Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Recurrent Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

The reemergence of monomorphic epitheliotropic intestinal T-cell lymphoma after a period of remission.


Small Intestinal Atypical Burkitt/Burkitt-Like Lymphoma

A morphologic variant of Burkitt lymphoma that arises from the small intestine.  It is characterized by marked nuclear pleomorphism, abundant apoptotic debris, and the presence of tangible body macrophages.


Transformed Non-Hodgkin Lymphoma

Histologic transformation of a usually indolent non-Hodgkin lymphoma to an aggressive non-Hodgkin lymphoma.


Prostate Follicular Lymphoma

A rare follicular lymphoma that arises from the prostate gland.


Burkitt's lymphoma of kidney

A rare Burkitt lymphoma arising from the kidney.


Adult T-cell lymphoma/leukemia recurrent

The reemergence of adult T-cell leukemia/lymphoma after a period of remission


Small Lymphocytic Lymphoma with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

Small lymphocytic lymphoma characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.


Unfavorable Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma with unfavorable prognosis.


Nodal marginal zone B-cell lymphoma stage III


Nodal marginal zone B-cell lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Recurrent Transformed B-Cell Non-Hodgkin Lymphoma

The reemergence of B-cell non-Hodgkin lymphoma transformed after a period of remission.


Refractory Grade 3a Follicular Lymphoma

Grade 3a follicular lymphoma that is resistant to treatment.


Refractory Nodular Lymphocyte Predominant Hodgkin Lymphoma

Nodular lymphocyte predominant Hodgkin lymphoma that is resistant to treatment.


Primary Iris Non-Hodgkin Lymphoma

An extremely rare low-grade B-cell non-Hodgkin lymphoma that arises from the iris. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Most cases represent extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


follicular lymphoma of lung

An exceedingly rare follicular lymphoma that arises in and is confined to the lung at the time of diagnosis.


breast diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma that arises from the breast. It is the most common type of primary breast lymphoma.


Lymphoplasmacytic Lymphoma by Ann Arbor Stage

An anatomic stage for lymphoplasmacytic lymphoma based on the Ann Arbor classification criteria.


Refractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Primary diffuse large B-cell lymphoma of the central nervous system that does not respond to treatment.


Lacrimal Drainage System Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the lacrimal sac. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


indolent B-cell non-Hodgkin lymphoma

A B-cell non-Hodgkin lymphoma with an indolent clinical course. Representative examples include grade 1 and grade 2 follicular lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma.


Mycosis Fungoides by AJCC v7 Stage

A term that refers to the staging of mycosis fungoides, following the rules of the TNM AJCC v7 classification system.


Cardiac Fibrin-Associated Diffuse Large B-Cell Lymphoma

A rare fibrin-associated diffuse large B-cell lymphoma that affects the heart.


Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma

A nodular lymphocyte predominant Hodgkin lymphoma occurring in children.


Recurrent Grade 3 Follicular Lymphoma

The reemergence of grade 3 follicular lymphoma after a period of remission.


Central Nervous System Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

A primary central nervous system non-Hodgkin lymphoma derived from mature or post-thymic T-cells or NK-cells.


Transformed Waldenstrom Macroglobulinemia to Diffuse Large B-Cell Lymphoma

Histologic transformation of Waldenstrom macroglobulinemia to an aggressive diffuse large B-cell lymphoma.


diffuse large B-cell lymphoma germinal center B-cell type

A diffuse large B-cell lymphoma that is characterized by the expression of CD10, BCL-6, A-myb, and LMO2 genes, BCL-2 translocation, and c-REL amplification.


Ann Arbor Stage I Mature T- and NK-Cell Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue by Ann Arbor Stage

An anatomic stage for extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue based on the Ann Arbor classification criteria.


AIDS-Related Primary Effusion Lymphoma

Primary effusion lymphoma occurring in HIV-positive patients.


Conjunctival Follicular Lymphoma

A follicular lymphoma that arises from the conjunctiva.


Lymphoepithelioid lymphoma

A variant of peripheral T-cell lymphoma, not otherwise specified.  It is characterized by the presence of neoplastic small lymphocytes infiltrating the lymph nodes in a diffuse and less frequently interfollicular pattern.  There is an associated proliferation of epithelioid histiocytes forming confluent clusters.


Stage IV Childhood Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Lugano Classification Stage IIE Adult Non-Hodgkin Lymphoma AJCC v8

Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Sezary syndrome recurrent

The reemergence of Sezary syndrome after a period of remission.


St. Jude Stage I Childhood Non-Hodgkin Lymphoma AJCC v8

Stage I: A single tumor (extranodal) or single anatomic area (nodal), with the exclusion of the mediastinum or abdomen. (from AJCC 8th Ed.)


Advanced Anaplastic Large Cell Lymphoma

Anaplastic large cell lymphoma that has spread extensively to distant anatomic sites.


Refractory Indolent B-Cell Non-Hodgkin Lymphoma

Indolent B-cell non-Hodgkin lymphoma that is resistant to treatment.


AIDS-Related Diffuse Large B-cell Lymphoma

A diffuse large B-cell lymphoma occurring in HIV-positive patients.


Primary mediastinal large B-cell lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Central Nervous System T-Cell Non-Hodgkin Lymphoma

A T-cell lymphoblastic lymphoma or a mature T-cell and NK-cell neoplasm that affects the brain, meninges, or spinal cord.


anaplastic large cell lymphoma of lung

A rare anaplastic large cell lymphoma that arises in the lung parenchyma.


Colorectal Mantle Cell Lymphoma

A mantle cell lymphoma that arises from the colon or rectum.  It often presents as a polypoid lesion.


Refractory Subcutaneous Panniculitis-Like T-Cell Lymphoma

Subcutaneous panniculitis-like T-cell lymphoma that is resistant to treatment.


Recurrent Aggressive Adult Non-Hodgkin Lymphoma

The reemergence of an aggressive adult non-Hodgkin lymphoma after a period of remission.


follicular lymphoma of thyroid gland

A rare follicular lymphoma primarily involving the thyroid gland.


Ann Arbor Stage II Supradiaphragmatic Nodular Lymphocyte Predominant Hodgkin Lymphoma


B-cell small lymphocytic lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


primary cutaneous follicle center lymphoma

A primary lymphoma of the skin composed of various numbers of small and large irregular neoplastic follicle center cells. Its morphologic pattern can be nodular, diffuse, or nodular and diffuse. It presents with solitary or grouped plaques and tumors, and it usually involves the scalp, forehead, or trunk. It rarely involves the legs. This type of cutaneous lymphoma tends to remain localized to the skin.


Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma

A mucosa-associated lymphoid tissue lymphoma affecting the conjunctiva.


Indolent Adult Non-Hodgkin Lymphoma

An indolent non-Hodgkin lymphoma occurring in adults.  Representative examples include small lymphocytic lymphoma, lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia, marginal zone B-cell lymphoma, and grade 1 and 2 follicular lymphoma.


Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

Small lymphocytic lymphoma characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


splenic diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma occurring in the spleen.


Noncutaneous Anaplastic Large Cell Lymphoma by Ann Arbor Stage

An anatomic stage for noncutaneous anaplastic large cell lymphoma based on the Ann Arbor classification criteria.


Refractory Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

Primary systemic anaplastic large cell lymphoma, ALK-positive that is resistant to treatment.


Stage IIIA Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IIIA includes: T4, N0-2, M0, B0. T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). (AJCC 8th ed.)


Adult Non-Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for adult non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Adult B Lymphoblastic Lymphoma

B-lymphoblastic lymphoma that occurs in adults.


Nasal Type NK/T-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for nasal type NK/T-cell lymphoma based on the Ann Arbor classification criteria.


Primary Cutaneous T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

T-Cell/histiocyte-rich large B-cell lymphoma that arises from the skin.


Intestinal T-cell lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Stage I Childhood Burkitt Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Recurrent Nodular Lymphocyte Predominant Hodgkin Lymphoma

The reemergence of nodular lymphocyte predominant Hodgkin lymphoma after a period of remission.


Small Intestinal B-Cell Non-Hodgkin Lymphoma

A B-cell non-Hodgkin lymphoma that arises from the small intestine.  Representative examples include diffuse large B-cell lymphoma, mucosa-associated lymphoid tissue lymphoma, alpha heavy chain disease/immunoproliferative small intestinal disease, Burkitt lymphoma, follicular lymphoma, and mantle cell lymphoma.


Mediastinal T Lymphoblastic Lymphoma

A precursor T-lymphoblastic lymphoma that arises from the mediastinum.  It usually presents with an anterior mediastinal mass and respiratory distress.  It may present acutely with superior vena cava syndrome.  It usually affects adolescent and young adult males.  It is treated with aggressive chemotherapy and radiation.  The prognosis is better in the pediatric patients.


Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

A T-cell non-Hodgkin lymphoma that arises from the skin and does not respond to treatment.


Indolent Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma with an indolent clinical course.


St. Jude Stage III Childhood Non-Hodgkin Lymphoma AJCC v8

Stage III: Two single tumors (extranodal) on opposite sides of the diaphragm. Two or more nodal areas above and below the diaphragm. All the primary intrathoracic tumors (mediastinal, pleural, and thymic). All extensive primary intra-abdominal disease. All paraspinal or epidural tumors, regardless of other tumor site(s). (from AJCC 8th Ed.)


Ann Arbor Stage II Aggressive Adult Non-Hodgkin Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Double-Expressor Lymphoma

A diffuse large B-cell lymphoma characterized by double expression of MYC and BCL2 proteins without MYC and BCL2 gene aberrations. These lymphomas may have a worse prognosis than other diffuse large B-cell lymphomas, not otherwise specified, but they are not as aggressive as the high-grade B-cell lymphomas, with rearrangements of MYC and BCL2 and/or BCL6 genes.


Peripheral T-cell lymphoma unspecified refractory

Peripheral T-cell lymphoma, not otherwise specified that is resistant to treatment.


Recurrent Adult Non-Hodgkin Lymphoma

The reemergence of non-Hodgkin lymphoma in adults after a period of remission.


B-cell non-Hodgkin lymphoma

The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003


Adult T Lymphoblastic Lymphoma

T-lymphoblastic lymphoma occurring in adults.


primary cutaneous anaplastic large cell lymphoma

Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is a rare T-cell non-Hodgkin lymphoma that affects the skin and generally shows no extracutaneous involvement at presentation. It belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders along with lymphomatoid papulosis with which it shares overlapping clinical and histopathologic features.


African Burkitt's lymphoma

A clinical variant of Burkitt lymphoma that occurs in equatorial Africa.  The Epstein-Barr virus has been detected in all patients.  It is the most common malignancy of childhood in this area.


The reemergence of Waldenstrom macroglobulinemia after a period of remission.


T-cell/histiocyte rich large B cell lymphoma (THRLBCL) is a rare variant of diffuse large B-cell lymphoma (DLBCL), mainly affecting middle-aged men and often not being discovered until an advanced disease stage, with involvement of the spleen, liver and bone marrow occurring at a greater frequency than in DLBCL. It is often difficult to diagnose due to its similarity with other lymphoid diseases such as classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma and has an aggressive clinical course.


Ann Arbor Stage I Nodular Lymphocyte Predominant Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Ann Arbor Stage IIX (Bulky) Non-Hodgkin Lymphoma

Ann Arbor Stage II non-Hodgkin lymphoma with a mass of nodes with one diameter more than 10cm or a mediastinal mass larger than one third of the transthoracic width. (Cotswolds modification)


large-cell immunoblastic lymphoma

Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.


Refractory Aggressive T-Cell Non-Hodgkin Lymphoma

An aggressive T-cell non-Hodgkin lymphoma that is resistant to treatment.


Adult T-cell lymphoma/leukemia stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Recurrent Childhood Lymphoblastic Lymphoma

The reemergence of lymphoblastic lymphoma in childhood after a period of remission.


Burkitt-Like Lymphoma Post-Transplant Lymphoproliferative Disorder

A Burkitt-like lymphoma that arises in a patient with a history of organ transplantation.


Refractory Nodal Peripheral T-Cell Lymphoma with TFH Phenotype

Nodal peripheral T-cell lymphoma with TFH phenotype that is resistant to treatment.


high-grade B-cell lymphoma double-hit/triple-hit

A B-cell lymphoma that is characterized by the abnormal rearrangement of two genes, MYC gene and either BCL2 or BCL6 genes.


Stage I Adult Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Splenic T Lymphoblastic Lymphoma

T-lymphoblastic lymphoma that affects the spleen.


Angioimmunoblastic T-cell lymphoma stage III


Small Intestinal Follicular Lymphoma

A follicular lymphoma that arises from the small intestine.  It most often affects the duodenum.


Nodular Lymphocyte Predominant Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for nodular lymphocyte predominant Hodgkin lymphoma based on the Ann Arbor classification criteria.


Breast T-Cell Non-Hodgkin Lymphoma

A T-cell non-Hodgkin lymphoma that arises from the breast as a primary tumor.  Primary T-cell non-Hodgkin lymphomas of the breast are rare.