Blasts 60 Percent or More of Peripheral Blood White Cells

A semi-quantitative microscopic finding indicating that 60 percent or more of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.


Blasts More than 60 Percent of Peripheral Blood White Cells

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

A semi-quantitative microscopic finding indicating that more than 60 percent of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.


Blasts More than 20 Percent of Peripheral Blood White Cells

A semi-quantitative microscopic finding indicating that more than 20 percent of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.


Blasts 20-30 Percent of Peripheral Blood White Cells

A semi-quantitative microscopic finding indicating that between 20 and 30 percent of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.


Lymphoblasts 20 Percent or More of Peripheral Blood White Cells

A semi-quantitative microscopic finding indicating that 20 percent or more of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells of lymphoid origin.


Blasts More than 10 Percent of Peripheral Blood White Cells

A semi-quantitative microscopic finding indicating that more than 10 percent of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.


Myeloblasts 10 Percent or More of Peripheral Blood White Cells

A semi-quantitative microscopic finding indicating that at least 10 percent of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells of myeloid origin.


sodium- and chloride-dependent GABA transporter 1 isoform 1 (rat)

A sodium- and chloride-dependent GABA transporter 1 isoform 1 that is encoded in the genome of rat.


Segmental peripheral demyelination

A loss of myelin from the internode regions along myelinated nerve fibers from segments of the peripheral nervous system.


Patchy demyelination of subcortical white matter

Patchy loss of myelin from nerve fibers in the central nervous system.


Symmetrical progressive peripheral demyelination

A symmetric and progressive loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.


Diffuse demyelination of the cerebral white matter

A diffuse loss of myelin from nerve fibers in the central nervous system.


A segmental pattern of demyelination and regeneration (remyelination) affecting peripheral nerves.


Symmetric peripheral demyelination

A symmetric loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.


Asymmetric peripheral demyelination

Loss of myelin from peripheral nerves in a pattern that differs between right and left.


Spinal cord posterior columns myelin loss


Cerebral hypomyelination

Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the white matter of the central nervous system.


CNS demyelination

A loss of myelin from nerve fibers in the central nervous system.


Diffuse peripheral demyelination

A diffuse loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.


Severe demyelination of the white matter

A severe loss of myelin from nerve fibers in the central nervous system.


Peripheral demyelination

A loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.


Sensory axonal neuropathy

An axonal neuropathy of peripheral sensory nerves.


vitamin K-dependent protein C N-glycosylated 25 (human)

A vitamin K-dependent protein C (human) that has been N-glycosylated at the residue equivalent to Asn-355 of the amino acid sequence represented by UniProtKB:P04070-1, in which the glycan structure is represented by GlyTouCan:G42440OJ. Example: UniProtKB:P04070-1, Asn-355, MOD:00160~GNO:G42440OJ.


Stage II Urethral Cancer AJCC v7

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

Stage II includes: T2, N0, M0.  T2: Tumor invades any of the following: corpus spongiosum, prostate, periurethral muscle.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Urethral Cancer by AJCC v7 Stage

A term that refers to the staging of urethral cancer according to the American Joint Committee on Cancer, 7th edition.


Stage I Urethral Cancer AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage 0 Urethral Cancer AJCC v7

Stage 0 includes: 0a (Ta, N0, M0); 0is (Tis, N0, M0); (Tis pu, N0, M0); (Tis pd, N0, M0).  Ta: Noninvasive papillary, polypoid, or verrucous carcinoma.  Tis: Carcinoma in situ.  Tis pu: Carcinoma in situ, involvement of the prostatic urethra.  Tis pd: Carcinoma in situ, involvement of the prostatic ducts.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


carcinoma in situ of urethra

A in situ carcinoma that involves the urethra.


Stage IV Urethral Cancer AJCC v7

Stage IV includes: (T4, N0, M0); (T4, N1, M0); (Any T, N2, M0), (Any T, Any N, M1).  T4: Tumor invades other adjacent organs.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node more than 2 cm in greatest dimension, or in multiple lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Stage 0a Urethral Cancer AJCC v7

Stage 0a includes: Ta, N0, M0.  Ta: Noninvasive papillary, polypoid, or verrucous carcinoma.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage III Urethral Cancer AJCC v7

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0), (T3, N1, M0).  T1: Tumor invades subepithelial connective tissue.  T2: Tumor invades any of the following: corpus spongiosum, prostate, periurethral muscle.  T3: Tumor invades any of the following: corpus cavernosum, beyond prostatic capsule, anterior vagina, bladder neck.  N1: Metastasis in a single lymph node 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Gallbladder Undifferentiated Carcinoma, Spindle and Giant Cell Type

An undifferentiated carcinoma that arises from the gallbladder.  It is characterized by the presence of spindle and giant malignant cells, including osteoclast-like giant cells.


Vulva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Vulva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Vulva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Vulva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Vulva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Duodenal Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


A rare primary bone dysplasia disorder characterized by congenital hypotrichosis associated with rhizomelic short stature (more pronounced in upper limbs than lower limbs), limited hip abduction and mild genu varum. Flared and irregular metaphyses, delayed and irregular epiphiseal ossification and pear-shaped vertebral bodies are characteristic radiologic findings.


Optic ataxia

Difficulty reaching visually guided goals in peripheral vision, with the deficit, leaves voluntary eye movements largely unaffected.


Chronic active Epstein-Barr virus infection

Chronic active Epstein-Barr virus (EBV) infection is an uncommon outcome of EBV infection and may present as a waxing and waning or fulminant syndrome. Unlike acute infectious mononucleosis, wherein EBV establishes lifelong infection and survives by maintaining a delicate balance with the host as a latent infection, in chronic active EBV infection the host-virus balance is disturbed.


FGFR2B Overexpression

An indication that overexpression of FGFR2B has been detected in a sample.


Aplastic nasopharyngeal adenoids

Absence of the nasopharyngeal adenoids as a developmental defect.


chondrodysplasia punctata, brachytelephalangic, autosomal


autosomal dominant chondrodysplasia punctata

Autosomal dominant form of chondrodysplasia punctata.


chondrodysplasia punctata, tibial-metacarpal type


Broad phalanges of the hand

Increased width of the phalanges of the hand.


Broad distal phalanx of the thumb

Increased width of the distal phalanx of thumb.


Broad 1st metacarpal

Increased width of the 1st metacarpal. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.


Spatulate thumbs

Spoon-shaped, broad thumbs.


Broad hallux phalanx

An increase in width in one or more phalanges of the big toe.


Broad middle phalanx of the 4th finger

Increased width of the middle phalanx of the 4th finger.


Broad metatarsal

Increased side-to-side width of a metatarsal bone.


Broad phalanges of the 3rd finger

Increased width of the phalanges of the 3rd finger.


Broad proximal phalanx of the 3rd finger

Increased width of the proximal phalanx of the 3rd finger.


Broad middle phalanx of the 2nd finger

Increased width of the middle phalanx of the second finger.


Broad radial metaphysis

Increase in width (breadth) of the radial metaphysis.


Broad clavicles

Increased width (cross-sectional diameter) of the clavicles.


Broad distal phalanx of finger

Abnormally wide (broad) distal phalanx of finger.


Broad first metatarsal

Increased side-to-side width of the first metatarsal bone.


Broad distal phalanx of the hallux

An increase in width of the distal phalanx of the big toe.


Broad phalanx

Increased side-to-side width of one or more phalanges of the fingers or toes.


Bulbous tips of toes

An abnormality of the morphology of the toes, such that the tips of the toes are prominent and bulbous.


Broad phalanges of the 4th finger

Increased width of the phalanges of the 4th finger.


Broad phalanx of the toes

Increased width of phalanx of one or more toes.


Broad proximal phalanges of the hand

Increased width of the proximal phalanges of the finger.


Broad ulna

Increased width of the ulna.


Broad proximal phalanx of the hallux

Increased width of proximal phalanx of big toe.


Broad middle phalanx of finger

Increased width of the middle phalanx of finger.


Broad proximal phalanx of the thumb

Increased width of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.


Broad distal phalanx of the 5th finger

Increased width of the distal phalanx of the 5th finger.


Broad metacarpals

Abnormally broad metacarpal bones.


Broad proximal phalanx of the 4th finger

Increased width of the proximal phalanx of the 4th finger.


Broad distal phalanx of the 4th finger

Increased width of the distal phalanx of the 4th finger.


Broad proximal phalanx of the 5th finger

Increased width of the proximal phalanx of the 5th finger.


Expanded phalanges with widened medullary cavities


Broad proximal phalanx of toe

An increase in width of one ore more proximal toe phalanges.


Increased fibular diameter

Increased width of the cross sectional diameter of the fibula.


Broad phalanges of the 5th finger

Increased width of the phalanges of the 5th finger.


Broad middle phalanx of the 5th finger

Increased width of the middle phalanx of the 5th finger.


Broad radius

Increased width of the radius.


Broad middle phalanx of the 3rd finger

Increased width of the middle phalanx of the 3rd finger.


Broad proximal phalanx of the 2nd finger

Increased width of the proximal phalanx of the 2nd finger.


Broad distal phalanx of the toes

Increased width of the distal phalanx of toe of one or more toes.


Broad distal phalanx of the 2nd finger

Increased width of the distal phalanx of the 2nd finger.


Broad distal phalanx of the 3rd finger

Increased width of the distal phalanx of the 3rd finger.


Broad distal phalanges of all fingers

Abnormally wide (broad) distal phalanx of finger of all fingers.


Broad thumb

Increased thumb width without increased dorso-ventral dimension.


Abnormal sixth cranial nerve morphology

Any structural abnormality of the abducens nerve.


hemoglobin D disease

Hemoglobin D disease(HbD) is a hemoglobinopathy characterized by production of abnormal variant hemoglobin known as hemoglobin D, with no or mild clinical manifestations (splenomegaly, very mild anemia).


solute carrier family 2, facilitated glucose transporter member 2 isoform h2 (human)

A solute carrier family 2, facilitated glucose transporter member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11168-2.


functioning pituitary gland neoplasm

A hormone producing pituitary gland tumor, associated with a hormonal syndrome.


TSH producing pituitary tumor

An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces thyrotropin.


TSH-secreting pituitary adenoma

A rare adenoma of the anterior lobe of the pituitary gland that produces thyrotropin. It is usually associated with goiter and hyperthyroidism.


functioning pituitary gland adenoma

A hormone producing pituitary gland adenoma, associated with a hormonal syndrome.


Nelson syndrome

A syndrome that develops following bilateral adrenalectomy for Cushing syndrome. The signs and symptoms result from the presence of an adenocorticotropin-secreting pituitary gland adenoma, and include enlargement of the sella turcica and pressure on the adjacent structures, and skin hyperpigmentation.


malignant thyroid stimulating hormone producing neoplasm of pituitary gland

A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces thyrotropin.


functioning gonadotropic adenoma

Functioning gonadotropic adenoma is a very rare pituitary tumor, macroscopically characterized by a soft, well vascularized, variable sized adenoma, with occasional areas of hemorrage or necrosis, that secretes biologically active gonadotropins. In addition to common neurological signs due to mass effect (headache and/or visual field deterioration), additional clinical manifestations include menstrual irregularities (secondary amenorrhea, oligomenorhea or severe menorrhagia), galactorrhea, infertility or ovarian hyperstimulation syndrome (in premenopausal women), testicular enlargement and, occasionally, hypogonadism (in men) and isosexual precocious puberty (in children).


Stage II Acral Lentiginous Melanoma AJCC v6 and v7

Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0).  T2b: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, with ulceration.  T3a: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, without ulceration.  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  T4b: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Ed.)


Grade 2 Neck Pain, CTCAE

Moderate pain; limiting instrumental ADL


cyclin-dependent kinase 8 isoform 1 (human)

A cyclin-dependent kinase 8 isoform 1 that is encoded in the genome of human.


serine/threonine-protein kinase tousled-like 1 isoform 1 (human)

A serine/threonine-protein kinase tousled-like 1 isoform 1 that is encoded in the genome of human.


progressive relapsing multiple sclerosis

A multiple sclerosis that is characterized by steadily worsening symptoms and attacks during periods of remission with disease progression from the onset.


Cutaneous stenosis of the external auditory canal


Metastatic Malignant Neoplasm to the Thyroid

A malignant neoplasm either directly extending to the thyroid gland from adjacent structures (e.g. pharynx, larynx, esophagus, cervical lymph nodes), or spreading to the thyroid gland from distant anatomic sites, most frequently kidney, lung, uterus, breast, and skin.  The majority of cases are carcinomas, lymphomas, and melanomas.


Metastatic malignant neoplasm to neck

A malignant neoplasm that has spread to the neck region from a malignancy in a local or distant anatomic site.


Metastatic malignant neoplasm to parathyroid gland

A malignant neoplasm either directly extending to the parathyroid glands from adjacent anatomic structures, or spreading to the parathyroid glands from distant anatomic sites, most frequently breast, lung, kidney, soft tissues, and skin.


Neck Carcinoma of Unknown Primary

A carcinoma that has metastasized to the neck region from an unknown primary anatomic site.


Metastatic malignant neoplasm to nasopharynx

A malignant neoplasm that has spread to the nasopharynx from another anatomic site.


Metastatic malignant neoplasm to oropharynx

A malignant neoplasm that has spread to the oropharynx from another anatomic site.


Metastatic malignant neoplasm to hypopharynx

A malignant neoplasm that has spread to the hypopharynx from another anatomic site.


Metastatic malignant neoplasm to larynx

A malignant neoplasm that has spread to the larynx from another anatomic site.


Neck Squamous Cell Carcinoma of Unknown Primary

A squamous cell carcinoma that has metastasized to the neck region from an unknown primary anatomic site.


Metastatic malignant neoplasm to pharynx

A malignant neoplasm that has spread to the pharynx from another anatomic site.


Recurrent Neck Squamous Cell Carcinoma of Unknown Primary

The reemergence of metastatic squamous cell carcinoma of unknown primary in the neck region after a period of remission.


Hypoplastic iris stroma

Underdevelopment of the stroma of iris.


icosanoid

Any member of the group of signalling molecules arising from oxidation of the three C20 essential fatty acids (EFAs) icosapentaenoic acid (EPA), arachidonic acid (AA) and dihomo-gamma-linolenic acid (DGLA).


Prostaglandin

Naturally occurring compounds derived from the parent C20 acid, prostanoic acid.


prostanoid

The family of natural prostaglandins and prostaglandin-like compounds including prostacyclins and thromboxanes.


Brown-Vialetto-van Laere syndrome 1

Any Brown-Vialetto-van Laere syndrome in which the cause of the disease is a mutation in the SLC52A3 gene.


Pelvic girdle amyotrophy

Atrophy of the muscles of the pelvic girdle (also known as hip girdle), i.e., the gluteal muscles, the lateral rotators, the adductors, the psoas major and the iliacus muscle.


Amyotrophy of the musculature of the pelvis

Muscular atrophy affecting the muscles of the pelvis.


intravascular fasciitis

A rare self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the vessels. It is characterized by the presence of plump spindle-shaped fibroblasts, multinucleated osteoclast-like giant cells, chronic inflammatory infiltrate, red blood cell extravasation, and high mitotic activity.


Stage IV Major Salivary Gland Carcinoma with Metastasis

Stage IV carcinoma of the major salivary glands with regional lymph nodes and/or distant metastases.


Cervical Micropapillary Adenocarcinoma

A rare, invasive adenocarcinoma that arises from the cervix and is characterized by a micropapillary architecture.


A steroid glucosiduronic acid that is calcitriol in which the hydroxy hydrogen at position 25 has been replaced by a beta-D-glucuronyl residue.


Late Stillbirth

Delivery of a dead fetus greater than 28 weeks gestational age and/or greater than 1,000 grams birth weight.


Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1, Any G. M1: Distant metastasis. (AJCC 8th ed.)


Gastroesophageal Junction Adenocarcinoma by AJCC v8 Pathologic Stage

A term that refers to the pathologic staging of gastroesophageal junction adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IIIB includes: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Pathologic Stage IA Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IA includes: (T1a, N0, M0, G1); (T1a, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. (AJCC 8th ed.)


Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IIIA includes: (T1, N2, M0, Any G); (T2, N1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Pathologic Stage 0 Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage 0 includes: Tis, N0, M0, GN/A. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. GN/A: Grade non-applicable. (AJCC 8th ed.)


Pathologic Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IIA includes: (T2, N0, M0, G3); (T2, N0, M0, GX). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Pathologic Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage I includes: IA: (T1a, N0, M0, G1); (T1a, N0, M0, GX); IB: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX); IC: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Pathologic Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage II includes: IIA: (T2, N0, M0, G3); (T2, N0, M0, GX); IIB: (T1, N1, M0, Any G); (T3, N0, M0, Any G). T2: Tumor invades the muscularis propria. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage III includes: IIIA: (T1, N2, M0, Any G); (T2, N1, M0, Any G); IIIB: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Pathologic Stage IC Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IC includes: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IVA includes: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Pathologic Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IIB includes: (T1, N1, M0, Any G); (T3, N0, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IV includes: IVA: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G); IVB: (Any T, Any N, M1, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Pathologic Stage IB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IB includes: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. (AJCC 8th ed.)


Refractory High Grade Burkitt-Like Lymphoma

High grade B-cell lymphoma Burkitt-like lymphoma resistant to treatment.


Recurrent High Grade Burkitt-Like Lymphoma

The reemergence of high grade B-cell lymphoma Burkitt-like lymphoma after a period of remission.


Stage II High Grade Adult Non-Hodgkin's Lymphoma


Stage II High Grade Burkitt-Like Lymphoma

Stage II NHL means involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


High Grade B-Cell Non-Hodgkin's Lymphoma


Stage I High Grade Burkitt-Like Lymphoma

Stage I NHL means involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Recurrent High Grade Adult Non-Hodgkin's Lymphoma


Stage IV High Grade Adult Non-Hodgkin's Lymphoma


Stage IV High Grade Burkitt-Like Lymphoma

Stage IV NHL means disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)


Stage III High Grade Adult Non-Hodgkin's Lymphoma


Stage I High Grade Adult Non-Hodgkin's Lymphoma


Stage III High Grade Burkitt-Like Lymphoma

Stage III NHL means involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


High Grade Burkitt-Like Lymphoma

A high grade B-cell lymphoma showing greater pleomorphism in nuclear size and shape than the classical Burkitt lymphoma.


Patchy sclerosis of the proximal phalanx of the 3rd toe


Stage IVB Esophageal Squamous Cell Carcinoma


sodium/nucleoside cotransporter 1 isoform h2 (human)

A sodium/nucleoside cotransporter 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00337-2.


lymphangioleiomyomatosis

A multifocal neoplasm with perivascular epithelioid cell differentiation affecting almost exclusively females of child-bearing age. It is characterized by the presence of smooth muscle and epithelioid cells and by the proliferation of lymphatic vessels. Sites of involvement include the lungs, mediastinum, and the retroperitoneum. It usually presents with chylous pleural effusion or ascites.


chronic sphenoidal sinusitis

Inflammation of the sphenoid sinus that typically lasts beyond eight weeks. It is caused by infections, allergies, and the presence of sinus polyps or a deviated septum. Signs and symptoms include headache, nasal discharge, swelling in the face, dizziness, and breathing difficulties.


A phytocannabinoid that is Delta(9)-tetrahydrocannabinol in which the C-11 methyl has been fully oxidised to a carboxy group. Further enzymatic oxidation product of 11-hydroxy-Delta(9)-tetrahydrocannabinol.


short transient receptor potential channel 6 isoform h1 (human)

A short transient receptor potential channel 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y210-1.


short transient receptor potential channel 6

A transient receptor potential cation channel TRPC3/6/7 that is a translation product of the human TRPC6 gene or a 1:1 ortholog thereof.


short transient receptor potential channel 6 isoform h3 (human)

A short transient receptor potential channel 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y210-3.


short transient receptor potential channel 6 N-glycosylated 2 (human)

A short transient receptor potential channel 6 (human) that has been N-glycosylated at the residue equivalent to Asn-473 of the amino acid sequence represented by UniProtKB:Q9Y210-1, in which the glycan composition is represented by GlyTouCan:G12580WI. Example: UniProtKB:Q9Y210-1, Asn-473, MOD:00160~GNO:G12580WI.


short transient receptor potential channel 6 N-glycosylated 1 (human)

A short transient receptor potential channel 6 (human) that has been N-glycosylated at the residue equivalent to Asn-473 of the amino acid sequence represented by UniProtKB:Q9Y210-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:Q9Y210-1, Asn-473, MOD:00160~GNO:G08293MJ.


short transient receptor potential channel 6 isoform h2 (human)

A short transient receptor potential channel 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y210-2.


Benign Nasolacrimal Duct Neoplasm

A non-metastasizing neoplasm that arises from the lacrimal duct.


Hodgkin lymphoma, nodular sclerosis, cellular phase

A nodular sclerosis Hodgkin lymphoma characterized by the presence of lacunar cells, nodular growth, and the absence of fibrosis.


troponin C, slow skeletal and cardiac muscles isoform 1 (human)

A troponin C, slow skeletal and cardiac muscles isoform 1 that is encoded in the genome of human.


Unresectable Cervical Adenosquamous Carcinoma

Cervical adenosquamous carcinoma that is not amenable to surgical resection.


Scapular winging

Abnormal protrusion of the scapula away from the surface of the back.


splicing factor 3B subunit 3 isoform h3 (human)

A splicing factor 3B subunit 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15393-3.


Vesicovaginal fistula

The presence of a fistula connecting the urinary bladder to the vagina.


Rectoperineal fistula

The presence of a fistula between the perineum and the rectum.


Urethrovaginal fistula

The presence of a fistula between the vagina and the urethra.


H-type rectovestibular fistula

Rectovestibular fistula with a normal anus is known as H-type fistula or double termination of the alimentary tract.


Perineal fistula

The presence of a fistula between the bowel and the perineum.


Anoperineal fistula

The presence of a fistula (abnormal tunnel) between the anal canal and the perineum.


Urachus fistula

Persistence of the urachal canal with drainage of urine from the bladder through the persistent allantois canal to the umbilicus.


Rectourethral fistula

An abnormal connection (fistula) between the rectum and the urethra.


Rectovaginal fistula

The presence of a fistula between the vagina and the rectum.


Rectoureteral fistula

An abnormal connection (fistula) between the rectum and the ureter.


Rectovestibular fistula

A congenital malformation characterized by an abnormal connection (fistula) between the rectum and the vulval vestibule, at the lower aspect of the vaginal opening.


Rectal fistula

The presence of a fistula affecting the rectum.


Bladder fistula

The presence of a fistula connecting the urinary bladder to another organ or the skin. The fistula can involve the bowel, the vagina, or rarely, the skin.


Colovesical fistula

An aberrant, pathological communication between the colon and the bladder.


Urethral fistula

The presence of an abnormal connection between the urethra and another organ or the skin.


Rectovesical fistula

An aberrant, pathological communication between the rectum and the bladder.


Grade 5 Pulmonary Hypertension, CTCAE

Death


Recurrent Unspecified Lung Carcinoma

Lung carcinoma that has re-emerged after a period of remission.


Large cell lung cancer recurrent

The reemergence of large cell lung carcinoma after a period of remission.


Recurrent Lung Non-Small Cell Squamous Carcinoma

The reemergence of lung squamous non-small cell carcinoma after a period of remission.


Recurrent Bronchogenic Carcinoma

The reemergence of bronchogenic carcinoma after a period of remission.


Non-small cell lung cancer recurrent

The re-emergence of non-small cell lung carcinoma after a period of remission.


Recurrent Lung Non-Squamous Non-Small Cell Carcinoma

The reemergence of non-squamous non-small cell lung carcinoma after a period of remission.


Adenosquamous cell lung cancer recurrent

The reemergence of adenosquamous lung carcinoma after a period of remission.


Lung adenocarcinoma recurrent

The re-emergence of lung adenocarcinoma after a period of remission.


Small cell lung cancer recurrent

The reemergence of small cell carcinoma of the lung after a period of remission.


Lung squamous cell carcinoma recurrent

The re-emergence of squamous cell lung carcinoma after a period of remission.


Recurrent Extensive Stage Lung Small Cell Carcinoma

Extensive stage small cell lung carcinoma that has reemerged after a period of remission.


pituitary gland basophilic carcinoma

A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with basic dyes.


Stage IA Vaginal Cancer AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Tumor confined to the vagina, measuring 2.0 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage I Vaginal Cancer AJCC v8

Stage I includes: IA: T1a, N0, M0; IB: T1b, N0, M0. T1a: Tumor confined to the vagina, measuring 2.0 cm or less. T1b: Tumor confined to the vagina, measuring more than 2.0 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IB Vaginal Cancer AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Tumor confined to the vagina, measuring more than 2.0 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Neutrophil Count 1000

Indicates a neutrophil count of at least 1000 per cubic millimeter.


Non-Neoplastic Chronic Lower Respiratory System Disorder

A non-neoplastic longstanding disorder of the lower respiratory system.


vulvar proximal-type epithelioid sarcoma

An epithelioid sarcoma of the proximal type involving the vulva.


Abnormality of the thenar eminence

An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb.


Small thenar eminence

Underdevelopment of the thenar eminence with reduced palmar soft tissue mass surrounding the base of the thumb.


Decreased renal tubular phosphate excretion


DNA polymerase beta unacetylated 1 (human)

A DNA polymerase beta (human) that lacks acetylation on the residue equivalent to Lys-72 of the amino acid sequence represented by UniProtKB:P06746. UniProtKB:P06746, Lys-72, PR:000026291.


delta-type opioid receptor isoform 1 (rat)

A delta-type opioid receptor isoform 1 that is encoded in the genome of rat.


Refractory Testicular Lymphoma

Testicular lymphoma that is resistant to treatment.


testicular lymphoma

A lymphoma that arises from the testis and is not associated with lymphoma in another anatomic site.


Recurrent Testicular Lymphoma

The reemergence of testicular lymphoma after a period of remission.


Testicular Follicular Lymphoma

A distinctive variant of follicular lymphoma arising from the testis. It has been reported with higher frequency in children, but is also seen rarely in adults. It differs biologically from nodal follicular lymphoma because it lacks evidence of the BCL2 translocation. It is usually of high cytological grade, usually grade 3A, but has a good prognosis, even without additional therapy beyond surgical excision. (WHO 2017)


Testicular Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that arises from the testis. It predominantly affects older men. Patients usually present with a unilateral hard painless mass. Bilateral masses have been described in a minority of patients.


Testicular Nasal Type Extranodal NK/T-Cell Lymphoma

A nasal type extranodal NK/T-cell lymphoma affecting the testis. Patients usually present with unilateral testicular enlargement. Bilateral involvement is rare. The prognosis is poor.


acid ceramidase isoform h2 (human)

An acid ceramidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13510-2.


Malignant Pancreatic Somatostatinoma

A neuroendocrine tumor that arises from the delta cells of the pancreas. It is characterized by inappropriate secretion of somatostatin and associated with diabetes mellitus, hypochlorhydria, gallbladder disease, diarrhea, steatorrhea, anemia, and weight loss. It displays vascular invasion and metastasizes to other anatomic sites.


Pancreatic Somatostatin-Producing Neuroendocrine Tumor

A usually malignant, somatostatin producing neuroendocrine tumor, arising from the delta cells of the pancreas.  It may or may not be associated with inappropriate secretion of somatostatin and an associated clinical syndrome.


pancreatic somatostatinoma

A neuroendocrine tumor arising from the delta cells of the pancreas. It is characterized by inappropriate secretion of somatostatin and associated with diabetes mellitus, hypochlorhydria, gallbladder disease, diarrhea, steatorrhea, anemia, and weight loss.


major salivary gland carcinoma

A carcinoma that arises from the parotid gland, submandibular gland, or sublingual gland.


major salivary gland carcinoma ex pleomorphic adenoma

A carcinoma that arises from a pleomorphic adenoma in the major salivary glands. It usually originates in the parotid gland. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive.


Recurrent Submandibular Gland Carcinoma

The reemergence of submandibular gland carcinoma after a period of remission.


Recurrent Parotid Gland Adenoid Cystic Carcinoma

The reemergence of parotid gland adenoid cystic carcinoma after a period of remission.


adenocarcinoma of parotid gland

An adenocarcinoma that arises from the parotid gland.  Representative examples include acinic cell carcinoma, basal cell adenocarcinoma, cystadenocarcinoma, and oncocytic carcinoma.


Stage IV Major Salivary Gland Carcinoma without Metastasis

Stage IV carcinoma of the major salivary glands without regional lymph nodes or distant metastases.


submandibular gland cancer

A malignant neoplasm involving the submandibular gland.


Submandibular Gland Squamous Cell Carcinoma

An invasive squamous cell carcinoma that arises from the submandibular gland.  It usually affects elderly patients and presents as a rapidly enlarging tumor mass, often associated with pain.


Stage IVC Major Salivary Gland Cancer AJCC v8

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Recurrent Submandibular Gland Undifferentiated Carcinoma

The reemergence of submandibular gland undifferentiated carcinoma after a period of remission.


mucoepidermoid carcinoma of submandibular gland

A mucoepidermoid carcinoma that involves the submandibular gland.


parotid gland squamous cell carcinoma

An invasive squamous cell carcinoma that arises from the parotid gland. It usually affects elderly patients and presents as a rapidly enlarging tumor mass, often associated with pain.


Recurrent Submandibular Gland Acinic Cell Carcinoma

The reemergence of submandibular gland acinic cell carcinoma after a period of remission.


Stage III Major Salivary Gland Cancer AJCC v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor measuring more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension.  Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.  T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension. T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage IV Major Salivary Gland Cancer AJCC v8

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T0, N2, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); (Any T, N3, M0); IVC (Any T, Any N, M1). T4a: Moderately advanced disease.  Tumor invades skin, mandible, ear canal, and/or facial nerve. T0: No evidence of primary tumor. T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension. T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension. T3: Tumor measuring more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension. T4b: Very advanced disease.  Tumor invades skull base and/or pterygoid plates and/or encases carotid artery. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(+); or more than 3 cm but not more than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-), or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-). N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or multiple ipsilateral, contralateral, or bilateral nodes any with ENE(+). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Major Salivary Gland Adenocarcinoma

An adenocarcinoma that arises from the parotid gland, submandibular gland, or sublingual gland.


Submandibular Gland Acinic Cell Carcinoma

An adenocarcinoma with serous acinar cell differentiation that arises from the submandibular gland.


Submandibular Gland Undifferentiated Carcinoma

A carcinoma that arises from the submandibular gland and is characterized by the presence of undifferentiated, anaplastic malignant epithelial cells.


adenocarcinoma of sublingual gland

An adenocarcinoma that arises from the sublingual gland.


Major Salivary Gland Cancer by AJCC v8 Stage

A term that refers to the staging of major salivary gland cancer according to the American Joint Committee on Cancer, 8th edition.


Stage I Major Salivary Gland Cancer AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension. Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IVA Major Salivary Gland Cancer AJCC v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Moderately advanced disease.  Tumor invades skin, mandible, ear canal, and/or facial nerve. T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension.  Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.  T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension.  T3: Tumor measuring more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Recurrent Submandibular Gland Mucoepidermoid Carcinoma

The reemergence of submandibular gland mucoepidermoid carcinoma after a period of remission.


Recurrent Parotid Gland Carcinoma ex Pleomorphic Adenoma

The reemergence of parotid gland carcinoma ex pleomorphic adenoma after a period of remission.


Stage II Major Salivary Gland Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Parotid Gland Carcinoma

The reemergence of parotid gland carcinoma after a period of remission.


Stage IVB Major Salivary Gland Cancer AJCC v8

Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0). T4b: Very advanced disease.  Tumor invades skull base and/or pterygoid plates and/or encases carotid artery. N0: No regional lymph node metastasis. N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or multiple ipsilateral, contralateral, or bilateral nodes any with ENE(+). M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Parotid Gland Squamous Cell Carcinoma

The reemergence of parotid gland squamous cell carcinoma after a period of remission.


carcinoma of parotid gland

A carcinoma that involves the parotid gland.


Recurrent Submandibular Gland Squamous Cell Carcinoma

The reemergence of submandibular gland squamous cell carcinoma after a period of remission.


Stage IVA Major Salivary Gland Cancer AJCC v8

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T0, N2, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Moderately advanced disease.  Tumor invades skin, mandible, ear canal, and/or facial nerve. T0: No evidence of primary tumor. T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension. T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension. T3: Tumor measuring more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(+); or more than 3 cm but not more than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-), or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


sublingual gland carcinoma

A carcinoma that arises from the sublingual gland. Representative examples include cystadenocarcinoma and mucoepidermoid carcinoma.


Stage 0 Major Salivary Gland Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Major Salivary Gland Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the parotid or submandibular gland.


Recurrent Parotid Gland Mucoepidermoid Carcinoma

The reemergence of parotid gland mucoepidermoid carcinoma after a period of remission.


major salivary gland mucoepidermoid carcinoma

A carcinoma that arises from the major salivary glands. It usually arises from the parotid gland. It is the most common primary carcinoma of the salivary glands and usually presents as a firm and painless mass. It is characterized by the presence of epidermoid cells, mucus producing cells, and cells of intermediate type. The majority of cases have a favorable outcome.


Recurrent Parotid Gland Acinic Cell Carcinoma

The reemergence of parotid gland acinic cell carcinoma after a period of remission.


major salivary gland adenoid cystic carcinoma

An aggressive carcinoma that arises from the major salivary glands. It is characterized by the presence of malignant epithelial and myoepithelial cells forming cribriform, tubular, and solid patterns. It usually presents as a slow growing mass. Patients develop pain because of the tendency of these carcinomas to invade perineural tissues.


Major Salivary Gland Cancer by AJCC v7 Stage

A term that refers to the staging of major salivary gland cancer according to the American Joint Committee on Cancer, 7th edition.


Submandibular Gland Carcinoma ex Pleomorphic Adenoma

A carcinoma that arises from a pleomorphic adenoma in the submandibular gland.  Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months.  Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis.  In cases where there is invasion of the surrounding tissues, the clinical course is aggressive.


Major Salivary Gland Acinic Cell Carcinoma

An adenocarcinoma with serous acinar cell differentiation that arises from the major salivary glands.  The vast majority of cases occur in the parotid gland.  Patients usually present with a slow growing mass in the parotid area.


parotid gland acinic cell carcinoma

An adenocarcinoma with serous acinar cell differentiation that arises from the parotid gland. Patients usually present with a slow growing mass in the parotid area.


submandibular gland adenocarcinoma

An adenocarcinoma that arises from the submandibular gland. Representative examples include polymorphic low-grade adenocarcinoma and acinic cell carcinoma.


mucoepidermoid carcinoma of parotid gland

A mucoepidermoid carcinoma that involves the parotid gland.


parotid gland carcinoma ex pleomorphic adenoma

A carcinoma that arises from a pleomorphic adenoma in the parotid gland. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive.


Stage IV Major Salivary Gland Cancer AJCC v7

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); (Any T, N3, M0); IVC (Any T, Any N, M1). T4a: Moderately advanced disease.  Tumor invades skin, mandible, ear canal, and/or facial nerve. T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension.  Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.  T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension.  T3: Tumor measuring more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension.  T4b: Very advanced disease.  Tumor invades skull base and/or pterygoid plates and/or encases carotid artery. N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


Recurrent Submandibular Gland Carcinoma ex Pleomorphic Adenoma

The reemergence of submandibular gland carcinoma ex pleomorphic adenoma after a period of remission.


Stage I Major Salivary Gland Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension. Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Parotid Gland Undifferentiated Carcinoma

A carcinoma that arises from the parotid gland and is characterized by the presence of undifferentiated, anaplastic malignant epithelial cells.


parotid gland adenoid cystic carcinoma

An aggressive carcinoma that arises from the parotid gland. It is characterized by the presence of malignant epithelial and myoepithelial cells forming cribriform, tubular, and solid patterns. It usually presents as a slow growing mass. Patients develop pain because of the tendency of these carcinomas to invade perineural tissues.


Recurrent Submandibular Gland Adenoid Cystic Carcinoma

The reemergence of submandibular gland adenoid cystic carcinoma after a period of remission.


Stage III Major Salivary Gland Cancer AJCC v8

Stage III includes: (T3, N0, M0); (T0, N1, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor measuring more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension.  T0: No evidence of primary tumor. T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension. T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


Stage IVC Major Salivary Gland Cancer AJCC v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Stage II Major Salivary Gland Cancer AJCC v7

Stage II includes: T2, N0, M0. T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension. Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Recurrent Parotid Gland Undifferentiated Carcinoma

The reemergence of parotid gland undifferentiated carcinoma after a period of remission.


submandibular gland adenoid cystic carcinoma

An aggressive carcinoma that arises from the submandibular gland. It is characterized by the presence of malignant epithelial and myoepithelial cells forming cribriform, tubular, and solid patterns. It usually presents as a slow growing mass. Patients develop pain because of the tendency of these carcinomas to invade perineural tissues.


Stage IVB Major Salivary Gland Cancer AJCC v7

Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Very advanced disease.  Tumor invades skull base and/or pterygoid plates and/or encases carotid artery. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


autosomal recessive osteopetrosis 4

Any autosomal recessive malignant osteopetrosis in which the cause of the disease is a mutation in the CLCN7 gene.


AIDS-Related Plasmablastic Lymphoma of the Oral Mucosa

A plasmablastic oral mucosa lymphoma in a patient with acquired immunodeficiency syndrome.


AIDS-Related Plasmablastic Lymphoma of Mucosa Site

A plasmablastic mucosal site lymphoma in a patient with acquired immunodeficiency syndrome.


Plasmablastic Lymphoma of the Oral Mucosa

A plasmablastic lymphoma arising in the oral cavity, usually associated with HIV infection.


localized junctional epidermolysis bullosa, non-Herlitz type

Junctional epidermolysis bullosa, localized non-Herlitz-type is a form of non-Herlitz junctional epidermolysis bullosa (JEB-nH) characterized by localized blistering, and dystrophic or absent nails.


junctional epidermolysis bullosa, non-Herlitz type

Junctional epidermolysis bullosa, non-Herlitz (JEB-nH) is a subtype of junctional epidermolysis bullosa (JEB) characterized by the presence of skin and mucosal blistering, nail dystrophy or nail absence and enamel hypoplasia.


generalized junctional epidermolysis bullosa non-Herlitz type

Generalized non-Herlitz-type junctional epidermolysis bullosa is a form of non-Herlitz-type junctional epidermolysis bullosa (JEB-nH) characterized by generalized skin blistering, atrophic scarring, nail dystrophy or nail absence, and enamel hypoplasia, with extracutaneous involvement.


Leukonychia

White discoloration of the nails.


Bifid epiglottis

A midline anterior-posterior cleft of the epiglottis that involves at least two-thirds of the epiglottic leaf. It is a useful feature for clinical diagnosis because it appears to be very rare in syndromes other than Pallister-Hall-Syndrome and is also rare as an isolated malformation.


Abnormal epiglottis morphology

An abnormality of the epiglottis.


Hypoplasia of the epiglottis

Hypoplasia of the epiglottis.


Aplasia/Hypoplasia of the Epiglottis

This term applies if the Epiglottis is absent or hypoplastic.


Aplasia of the epiglottis

Absence of the epiglottis.


carbonic anhydrase 1 isoform 1 (human)

A vertebrate-type carbonic anhydrase 1 isoform 1 that is encoded in the genome of human.


carbonic anhydrase 1, initiator methionine removed form (human)

A carbonic anhydrase 1 (human) that has had the initiator methionine removed. UniProtKB:P00915, 2-261.


ephrin type-B receptor 4 isoform h2 (human)

An ephrin type-B receptor 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54760-2.


acute intestinal ischemia

Ischemia of the intestine that is rapid in onset.


chronic gonococcal salpingitis

Chronic form of gonococcal salpingitis.


Hypergastrinemia

An elevated amount of gastrin in the blood.


Abnormal circulating gastrin concentration

An abnormal concentration of gastrin in the blood.


Breast Cellular Fibroadenoma

A fibroadenoma characterized by the presence of a pericanalicular growth pattern, increased stromal cellularity, and less than 2 mitoses per 10 high-power fields.


A disorder seen following cancer chemotherapy. It typically manifests a few years after initiation of epipodophyllotoxin chemotherapy. Mutagenic potential of these non-intercalating DNA topoisomerase II inhibitors is believed to be increased with concurrent use of asparaginase or granulocyte colony-stimulating factor. Balanced translocations involving chromosomal bands 11q23 and 21q22 are commonly associated with this disorder. Clinical signs may include fatigue, dyspnea, bruising and frequent infections. Clinical course usually progresses to acute myeloid leukemia though most epipodophyllotoxin-related leukemias do not have an antecedent myelodysplastic phase. Prognosis is dismal with survivability usually less than one year.


liver inflammatory myofibroblastic tumor

A multinodular intermediate fibroblastic neoplasm arising from the liver. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.


sex hormone-binding globulin isoform, signal peptide removed glycosylated 3 (human)

A sex hormone-binding globulin isoform with conserved glycosylation sites (human) that has had the signal peptide removed and has been post-translationally modified to include O-glycosylation and N-glycosylation on residues equivalent to Thr-36 and Asn-396, respectively, of the amino acid sequence represented by UniProtKB:P04278-1. Example: UniProtKB:P04278-1, 30-402, Thr-36, MOD:00164|Asn-396, MOD:00831.


sex hormone-binding globulin isoform, signal peptide removed glycosylated 13 (human)

A sex hormone-binding globulin isoform, signal peptide removed glycosylated 3 (human) whose N-linked glycan structure is UniCarbKB:7846. Example: UniProtKB:P04278-1, 30-402, Thr-36, MOD:00164|Asn-396, UniCarbKB:7846.


sex hormone-binding globulin isoform, signal peptide removed glycosylated 15 (human)

A sex hormone-binding globulin isoform, signal peptide removed glycosylated 3 (human) whose N-linked glycan structure is UniCarbKB:7764. Example: UniProtKB:P04278-1, 30-402, Thr-36, MOD:00164|Asn-396, UniCarbKB:7764.


sex hormone-binding globulin isoform, signal peptide removed glycosylated 12 (human)

A sex hormone-binding globulin isoform, signal peptide removed glycosylated 3 (human) whose N-linked glycan structure is UniCarbKB:7763. Example: UniProtKB:P04278-1, 30-402, Thr-36, MOD:00164|Asn-396, UniCarbKB:7763.


sex hormone-binding globulin isoform, signal peptide removed glycosylated 10 (human)

A sex hormone-binding globulin isoform, signal peptide removed glycosylated 3 (human) whose N-linked glycan structure is UniCarbKB:7863. Example: UniProtKB:P04278-1, 30-402, Thr-36, MOD:00164|Asn-396, UniCarbKB:7863.


sex hormone-binding globulin isoform, signal peptide removed glycosylated 14 (human)

A sex hormone-binding globulin isoform, signal peptide removed glycosylated 3 (human) whose N-linked glycan structure is UniCarbKB:7674. Example: UniProtKB:P04278-1, 30-402, Thr-36, MOD:00164|Asn-396, UniCarbKB:7674.


sex hormone-binding globulin isoform, signal peptide removed glycosylated 11 (human)

A sex hormone-binding globulin isoform, signal peptide removed glycosylated 3 (human) whose N-linked glycan structure is UniCarbKB:7834. Example: UniProtKB:P04278-1, 30-402, Thr-36, MOD:00164|Asn-396, UniCarbKB:7834.


phosphoenolpyruvate carboxykinase deficiency, cytosolic

PEPCK1 deficiency is a rare inborn error of metabolism disorder, characterized by the deficiency of the enzyme PEPCK1, one of the enzymes needed for gluconeogenesis, the process by which organisms produce sugars (namely glucose) from non-carbohydrate precursors (such as amino acids). The symptoms described in the few cases reported in the medical literature suggest that there may be variation in the severity of the symptoms ranging from severe early-onset cases, to milder late-onset presentations. In severe cases symptoms may include persistent and very low levels of blood's sugar in newborns (neonatal hypoglycemia), failure to thrive, build-up of lactic acid in the blood (lactic acidosis), liver enlargement (hepatomegaly) and liver failure leading to neurological degeneration. Milder cases present during childhood with fewer and less serious liver problems. Infections and fasting may trigger the symptoms. PEPCK1 deficiency inheritance is autosomal recessive. It is caused by mutations in the PEPCK1 gene. Some researchers believe that the severity of the disease depend upon the mutations resulting in less or more PEPCK1 activity (the more active the enzyme is, the less severe the disease is, and vice versa). Treatment depend on the symptoms and may include giving extra carbohydrates during heavy exercise and illness or other times of fasting (formal sick day regimen) by the dietitian.PEPCK1 is the cytosolic form of the phosphoenolpyruvate carboxykinase (PEPCK) enzyme, the other being the mitochondrial (PEPCK2).


Eventration

A localized protrusion of a structure into an adjacent structure or cavity.


diaphragmatic eventration

A congenital or acquired abnormality characterized by elevation of the hemidiaphragm.


Epidermal Growth Factor Receptor Inhibitor-Induced Acneiform Lesion

Acneiform dermatitis caused by epidermal growth factor receptor inhibitory therapy in a dose-dependent manner.


EBV-Related Carcinoma

Carcinoma that develops in individuals infected with Epstein-Barr virus (EBV), and in which there is a well-documented association between the neoplastic process and EBV.


Epstein-Barr virus-associated gastric carcinoma

Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) is a rare form of gastric carcinoma (seen in approximately 10% of cases) with a male predominance, characterized by a latent EBV infection in gastric carcinoma cells, diffuse-type histology, a proximal location (in the body and cardia of the stomach) and a relatively favorable prognosis.


leukocyte adhesion deficiency 3

Leukocyte adhesion deficiency type III (LAD-III) is a form of LAD characterized by both severe bacterial infections and a severe bleeding disorder.


Low Grade Pancreatic Intraepithelial Neoplasia

Pancreatic intraepithelial neoplasia characterized by the presence of low grade epithelial dysplasia.


Pancreatic Intraepithelial Neoplasia-1A

A pancreatic intraepithelial neoplasia characterized by the presence of tall columnar cells that form flat architectural patterns.  Mild cytological atypia is present.


Moderate pancreatic duct dysplasia

A pancreatic mucinous intraepithelial neoplasia characterized by the presence of papillary and less often flat architectural patterns.  Moderate cytological atypia is present with some loss of nuclear polarity, nuclear crowding or hyperchromatism.


Pancreatic Intraepithelial Neoplasia-1B

A pancreatic intraepithelial neoplasia characterized by the presence of tall columnar cells that form papillary, micropapillary, or basally pseudostratified architectural patterns.  Mild cytological atypia is present.


Pancreatic Intraepithelial Neoplasia-1

A pancreatic intraepithelial neoplasia characterized by the presence of tall columnar cells that form flat or papillary, micropapillary, and basally pseudostratified architectural patterns.  Mild cytological atypia is present.


Early balding

Loss of scalp hair at an earlier than normal age.


Grade 3 Major Visceral Artery Intra-Operative Injury, CTCAE


Grade 3 Neonatal Administration Site Complication, AE

An administration site complication adverse event in a newborn characterized by ulceration or necrosis; severe tissue damage; operative intervention indicated.


Neonatal Administration Site Complication, AE

An adverse event in a newborn characterized by local irritation or a complication at the administration site of a drug.


Grade 2 Neonatal Administration Site Complication, AE

An administration site complication adverse event in a newborn characterized by erythema with associated symptoms (e.g., edema, pain, induration, phlebitis).


Grade 5 Neonatal Administration Site Complication, AE

An administration site complication adverse event in a newborn which results in death.


Grade 4 Neonatal Administration Site Complication, AE

An administration site complication adverse event in a newborn characterized by life-threatening consequences; urgent intervention indicated.


Grade 1 Neonatal Administration Site Complication, AE

An administration site complication adverse event in a newborn characterized by painless edema.


taste receptor type 2 member 5

A taste receptor type 2 that is a translation product of the human TAS2R5 gene or a 1:1 ortholog thereof.


Patient-Specific Neoantigen-Positive Malignant Solid Neoplasm

A malignant solid neoplasm that expresses unique tumor-specific neoantigens in a single patient.


Grade 2 Myocardial Infarction, CTCAE

Asymptomatic and cardiac enzymes minimally abnormal and no evidence of ischemic ECG changes


serine/threonine-protein kinase 26 isoform h2 (human)

A serine/threonine-protein kinase 26 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9P289-2.


Retinal fold

A wrinkle of retinal tissue projecting outward from the surface of the retina and visible as a line on fundoscopy.


Retinal detachments and defects, unspecified

An imperfection if the retina of the eye in association with detachment of the retina from its blood supply.


rhegmatogenous retinal detachment

Retinal detachment secondary to retinal tear or break.


Tractional retinal detachment

A type of retinal detachment arising due to a combination of contracting retinal membranes, abnormal vitreoretinal adhesions, and vitreous changes. It is usually seen in the context of diseases that induce a fibrovascular response, e.g. diabetes.


chromosome 4Q32.1-q32.2 triplication syndrome


partial duplication of the long arm of chromosome 4

Chromosome 4q duplication is a chromosome abnormality characterized by an extra copy (duplication) of genetic material on the long arm (q) of chromosome 4. The severity and specific symptoms depend on the size and location of the duplication, and which genes are involved. Features that have been described in some people with chromosome 4q duplication include developmental delay, intellectual disability, behavioral problems, birth defects, and distinctive facial features. Most cases are inherited from an unaffected parent with a chromosomal rearrangement called a balanced translocation. Some cases are not inherited and occur sporadically. Treatment is based on the signs and symptoms present in each person.


distal trisomy 4q

Distal trisomy 4q is a rare chromosomal anomaly syndrome, resulting from the partial duplication of the long arm of chromosome 4, with highly variable phenotype typically characterized by psychomotor delay, intellectual disability, craniofacial dysmorphism (microcephaly, low-set, prominent ears, downslanting palpebral fissures, hypertelorism, epicanthic folds, broad, prominent nasal bridge, high arched and cleft palate, micro-/retrognathia), seizures, as well as tooth and digital anomalies (clinodactyly, polydactyly). Cardiac malformations, renal anomalies, cryptorchidism, hypotonia and hearing impairment have also been reported.


Chronic gouty nephropathy

Chronic kidney disease resulting from deposition of urate crystals or microtophi in the medullary interstitium.


Non-Neoplastic Kidney Disorder

A non-neoplastic disorder that affects the renal parenchyma and/or renal pelvis. Representative examples include glomerulonephritis and pyelonephritis.


Minimal mesangial lupus nephritis

A subclass of lupus nephritis with normal glomeruli by light microscopy, but mesangial immune deposits by immunofluorescence.


Nephrotic Syndrome - ADCK4 Associated

Nephrotic syndrome attributed to mutation(s) in the ADCK4 gene.


multicystic dysplastic kidney

Multicystic dysplastic kidney (MCDK) is a congenital anomaly of the kidney and urinary tract (CAKUT) in which one or both kidneys (unilateral or bilateral MCDK respectively) are large, distended by multiple cysts, and non-functional.


Nephrotic Syndrome - MYO1E Associated

Nephrotic syndrome attributed to mutation(s) in the MYO1E gene.


karyomegalic interstitial nephritis

Any interstitial nephritis in which the cause of the disease is a mutation in the FAN1 gene.


Obesity Related Glomerulopathy

Diffuse glomerular (greater than 50% of glomeruli) hypertrophy (greater than 250 micron diameter) that occurs in the context of obesity.


tubulointerstitial kidney disease, autosomal dominant, 2

An inherited disorder that causes a gradual loss of kidney function, caused by a mutation in the MUC1 gene that leads to production of an abnormal mucin 1 protein, which deposits in the kidney and leads to slow loss of kidney function.


Proximal tubulopathy

Dysfunction of the proximal tubule, which is the portion of the duct system of the nephron of the kidney which leads from Bowman's capsule to the loop of Henle.


Membranous Nephropathy - THSD7A Induced

Membranous nephropathy due to thrombospondin type-1 domain-containing protein 7A (THSD7A) antibodies.


Pauci-Immune Glomerulonephritis - Renal Limited

Glomerulonephritis in which anti-neutrophil cytoplasm antibody (ANCA) is almost always present and vasculitis is limited to the kidney.


Acute Cortical Necrosis

Acute kidney injury caused by ischemic necrosis of the renal cortex.


steroid-resistant nephrotic syndrome

Nephrotic syndrome, occurring in the pediatric population, in which proteinuria does not normalize with administration of steroids; this condition is unresponsive to a minimum of four weeks administration of oral corticosteroids.


end stage renal failure

Long-standing and persistent renal disease with glomerular filtration rate (GFR) less than 15 ml/min.


Nephropathy due to Ciclosporin

Kidney damage resulting from ciclosporin.


Chronic kidney disease due to hypertension

Longstanding kidney disease as a complication of hypertension.


Stage 1 chronic kidney disease

A type of chronic kidney disease with normal or increased glomerular filtration rate (GFR at least 90 mL/min/1.73 m2).


Nephrotic Syndrome - Simian Virus 40 Associated

Nephrotic syndrome associated with a simian virus 40 infection.


Cryoglobulinemic Glomerulonephritis Secondary to Systemic Disease

Cryoglobulinemia glomerulonephritis associated with chronic disease, often inflammatory conditions.


Pierson syndrome

Pierson syndrome is characterized by the association of congenital nephrotic syndrome and ocular anomalies with microcoria.


Nephrotic Syndrome - Human Immunodeficiency Virus Associated

Nephrotic syndrome associated with human immunodeficiency virus infection.


pyonephrosis

Pus within the collecting system of the kidney.


Uric acid nephropathy acute

Kidney damage resulting from uric acid precipitation within the renal tubules.


contrast-induced nephropathy

Kidney damage resulting from exposure to contrast agents.


Diffuse lupus nephritis

A subclass of lupus nephritis with active or inactive diffuse, segmental or global endocapillary or extracapillary glomerulonephritis involving at least 50% of all glomeruli, typically with diffuse subendothelial immune deposits, with or without mesangial alterations.


Tubulointerstitial nephritis resulting from a drug exposure.


Renal Pelvis Fibroepithelial Polyp

A benign, mesodermal tumor located in the renal pelvis.


Nephrotic syndrome with lesion of proliferative glomerulonephritis

A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by an inflammatory reaction of the glomerular capillaries due to the proliferation of mesangial cells and expansion of the mesangial matrix. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure.


Reflux nephropathy (disorder)

Chronic kidney damage due to vesicoureteral reflux.


Nephropathy due to Tacrolimus

Kidney damage resulting from tacrolimus.


Congenital Nephrotic Syndrome - Rubivirus Associated

Nephrotic syndrome associated with rubella, most commonly presenting in the first three months of life.


Nephrotic Syndrome - Infection Associated

Nephrotic syndrome associated with an infectious process.


Nephrotic Syndrome - SMARCAL1 Associated

Nephrotic syndrome attributed to mutation(s) in the SMARCAL1 gene.


glomerulopathy with fibronectin deposits 2

Any fibronectin glomerulopathy in which the cause of the disease is a mutation in the FN1 gene.


Nephrotic Syndrome - CFH Associated

Nephrotic syndrome attributed to mutation(s) in the CFH gene.


Acute renal papillary necrosis with renal failure

Sudden and sustained deterioration of the kidney function with decreased glomerular filtration rate, and concommittant necrosis of the renal papillae; representative causes include sickle cell disease, heave analgesic use, diabetes mellitus, and pyelonephritis.


Nephrotic Syndrome - ITGA3 Associated

Nephrotic syndrome attributed to mutation(s) in the ITGA3 gene.


Pauci-Immune Glomerulonephritis associated with Microscopic Polyangiitis

Glomerulonephritis in the context of systemic, small vessel vasculitis in which anti neutrophil cytoplasm antibody (ANCA) is almost always present.


Nephropathy due to Aminoglycosides

Kidney damage resulting from aminoglycosides.


Mesangial proliferative glomerulonephritis (MPGN) is a condition that affects the kidneys. Many experts consider it a variant of minimal change disease, but some experts believe it is a separate condition. It may present with nephrotic syndrome, which is a group of symptoms that include protein in the urine (proteinuria), low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling. It can also present with blood in the urine (hematuria). MPGN is characterized by an increased number of mesangial cells in the glomeruli in the kidneys and damage to the glomeruli. Glomeruli are the structures that help filter wastes and fluids. MPGN may occur in several renal diseases such as IgA nephropathy (commonly), IgM nephropathy, lupus nephritis, and C1q nephropathy.However, in some cases, the underlying cause of MPGN remains unclear. Treatment may depend on the cause (if known) and may include steroids, mycophenolate mofetil, and/or cyclophosphamide, and other therapies to treat specific symptoms. Most people with MPGN have a good prognosis, but some may develop chronic kidney disease, which can progress to end stage renal failure.


Chronic glomerulonephritis with lesion of membranous glomerulonephritis

A slowly progressive inflammation of the glomeruli characterized by immune complex deposits on the epithelial side of the glomerular basement membrane.


Idiopathic membranous glomerulonephritis (IMG) is a primary glomerular disease characterized by proteinuria, usually in the nephrotic range, with preserved renal function.


Membranous Nephropathy - Autoimmune Disorder Associated

Membranous nephropathy associated with an autoimmune disorder.


Nephrotic Syndrome - CRB2 Associated

Nephrotic syndrome attributed to mutation(s) in the CRB2 gene.


obstructive nephropathy

Renal damage and impaired renal function secondary to urinary tract obstruction.


Familial immunoglobulin A nephropathy

IgA nephropathy secondary to a genetic mutation that is transmitted from parents to offspring.


Acquired calyceal diverticulum

An out-pouching of the calyx into the renal parenchyma.


Nephrotic Syndrome - PDSS2 Associated

Nephrotic syndrome attributed to mutation(s) in the PDSS2 gene.


Nephrotic Syndrome with Lesion of Focal Glomerulosclerosis

A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by scarring of some of the glomerular capillaries. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure.


diffuse glomerulonephritis

Inflammation of the glomeruli, in which all glomeruli are affected, resulting in renal failure.


Nephrotic Syndrome - COQ2 Associated

Nephrotic syndrome attributed to mutation(s) in the COQ2 gene.


Systemic Lupus Erythematosus Nephritis Class V

Systemic lupus erythematosus nephritis, with global or segmental subepithelial immune deposits or their morphologic sequelae by light microscopy and by immunofluorescence or electron microscopy, with or without mesangial alterations. (Weening, Jan J. et al. (2004). The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited. Journal of the American Society of Nephrology 15(2), 241-50.)


Hantavirus nephropathy

Tubulointerstitial hemorrhage resulting from hantavirus infection.


Henoch-Schonlein purpura nephritis

Glomerulonephritis in the context of Henoch-Schönlein purpura.


Chronic Kidney Disease due to Diabetes Mellitus

Longstanding kidney disease as a complication of diabetes.


Steroid-dependent nephrotic syndrome

A type of nephrotic syndrome in which two consecutive relapses (albumin urine dipstick at least 3+ or proteinuria greater than 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) occur during corticosteroid therapy, or within 14 days of ceasing therapy.


Leptospirosis Nephropathy

Interstitial nephritis due to Leptospira, which may be associated with non-oliguric acute kidney injury.


idiopathic nephrotic syndrome

Nephrotic syndrome for which no cause has been identified.


Cryoglobulinemic glomerulonephritis

Glomerulonephritis in the context of cryoglobulinemia.


Chemotherapeutic Drug - Induced Nephropathy

Kidney damage resulting from exposure to chemotherapeutic drugs.


IgM - Associated Nephropathy

A condition characterized by deposition of IgM antibody in the glomerulus.


NSAID-Induced Nephropathy

Kidney damage resulting from exposure to non-steroidal anti-inflammatory drugs (NSAIDs).


Idiopathic Membranous Glomerulopathy

Chronic degenerative changes in the kidney characterized by thickened and inflamed glomeruli and proteinurea, the cause of which is unknown.


Microcystic renal disease

A congenital renal disorder characterized by the presence of small cysts in the renal cortex and/or renal medulla.


Focal lupus nephritis

A subclass of lupus nephritis with active or inactive focal, segmental or global endocapillary or extracapillary glomerulonephritis involving less than 50% of all glomeruli, typically with focal subendothelial immune deposits, with or without mesangial alterations


Idiopathic Renal Papillary Necrosis

Necrosis of the renal papillae, for which no underlying cause has been identified.


Diffuse glomerulosclerosis

A renal disorder characterized by glomerular damage due to ischemia. It leads to progressive deterioration of renal function.


Nephrotic Syndrome with Lesion of Persistent Glomerulonephritis

A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by a chronic inflammatory reaction in the glomerular capillaries. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure.


Systemic Lupus Erythematosus Nephritis Class IV G

Systemic lupus erythematosus nephritis, characterized by active or inactive diffuse, global endo- or extracapillary glomerulonephritis that involves 50% or more of all glomeruli. (Weening, Jan J. et al. (2004). The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited. Journal of the American Society of Nephrology 15(2), 241-50.)


Nephrotic Syndrome - ARHGAP24 Associated

Nephrotic syndrome attributed to mutation(s) in the ARHGAP24 gene.


chronic renal failure syndrome

Impairment of the renal function due to chronic kidney damage.


familial nephrotic syndrome

An instance of nephrotic syndrome that is caused by an inherited modification of the individual's genome.


Stage 4 chronic kidney disease

A type of chronic kidney disease with severely reduced glomerular filtration rate (GFR 15-29 mL/min/1.73 m2).


Advanced sclerotic lupus nephritis

A subclass of lupus nephritis with at least 90% of glomeruli globally sclerosed without residual activity.


Calcineurin Inhibitor - Induced Nephropathy

Kidney damage resulting from exposure to calcineurin inhibitors.


Congenital Nephrotic Syndrome - Cytomegalovirus Associated

Nephrotic syndrome associated with a cytomegalovirus infection, most commonly presenting in the first three months of life.


Light Chain Proximal Tubulopathy without Crystals

A morphologic variant of light chain proximal tubulopathy with no evidence of crystal formation. It is characterized by acute tubular injury with no evidence lysosomal immunoglobulin crystals.


familial juvenile hyperuricemic nephropathy type 1

A rare kidney disorder characterized by hyperuricemia, progressive nephropathy, and gout occurring at an early age.


Nephrotic Syndrome - CD2AP Associated

Nephrotic syndrome attributed to mutation(s) in the CD2AP gene.


polycystic kidney disease 2

Autosomal dominant polycystic kidney disease caused by a mutation in PKD2.


Nephrotic Syndrome - Toxoplasmosis Associated

Nephrotic syndrome associated with a toxoplasmosis infection.


Nephrotic Syndrome - ARHGDIA Associated

Nephrotic syndrome attributed to mutation(s) in the ARHGDIA gene.


Acute glomerulonephritis

An acute inflammation of the glomeruli, generally secondary to infection or injury.


Nephrotic Syndrome - Syphilis Associated

Nephrotic syndrome associated with a syphilis infection.


Nephrotic Syndrome - NPHS2 Associated

Nephrotic syndrome attributed to mutation(s) in the NPHS2 gene.


C3 Glomerulopathy with Monoclonal Gammopathy

A subset of C3 glomerulopathy in which there is an associated finding of monoclonal gammopathy.


Nephrotic Syndrome - CUBN Associated

Nephrotic syndrome attributed to mutation(s) in the CUBN gene.


crescentic glomerulonephritis

A histopathologic term for a pattern of diseases characterized by extensive crescent formation in the glomeruli; patients present clinically with rapid deterioration of renal function, and possible progression to end-stage renal failure within weeks or months.


Malignant Hypertensive Nephropathy

Hypertensive nephropathy secondary to malignant hypertension.


Systemic Lupus Erythematosus Nephritis Class IV S

Systemic lupus erythematosus nephritis characterized by active or inactive diffuse, segmental endo- or extracapillary glomerulonephritis that involves 50% or more of all glomeruli. (Weening, Jan J. et al. (2004). The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited. Journal of the American Society of Nephrology 15(2), 241-50.)


Lithium - Induced Nephropathy

Kidney damage resulting from lithium which may include distal or collecting tubular cysts, proteinuria, interstitial nephritis and nephrogenic diabetes insipidus.


Secondary Collapsing Glomerulopathy

Collapsing glomerulopathy for which an underlying cause has been identified.


Postpartum acute renal failure

Renal failure that occurs postpartum due to any partum problem (hemorrhage, sepsis, preeclampsia).


Nephrotic Syndrome - INF2 Associated

Nephrotic syndrome attributed to mutation(s) in the INF2 gene.


Congenital Nephrotic Syndrome - Toxoplasma Associated

Nephrotic syndrome associated with toxoplasmosis, most commonly presenting in the first three months of life.


xanthogranulomatous pyelonephritis

Chronic, destructive infection of the kidney characterized by lipid-laden macrophages in the setting of obstruction secondary to infected renal stones, most commonly caused by Proteus or Escherichia coli.


Nephrotic Syndrome - ANLN Associated

Nephrotic syndrome attributed to mutation(s) in the ANLN gene.


Acute cellular allograft nephropathy

A sudden onset of T-cell mediated immune response occurring after transplantation, directed against donor kidney alloantigens.


HIV-associated nephropathy

Renal disease in human immunodeficiency virus (HIV)-infected patients. It is characterized by nephrotic syndrome, azotemia, normal to large kidneys on ultrasound images, and focal segmental glomerulosclerosis on renal biopsy findings.


Nephrotic Syndrome - EMP2 Associated

Nephrotic syndrome attributed to mutation(s) in the EMP2 gene.


Membranous Nephropathy - Malignancy Associated

Membranous nephropathy in the context of malignancy.


kidney hypertrophy

Global enlargement of the renal parenchyma in one or both kidneys.


Nephrotic Syndrome with Lesion of Membranous Glomerulonephritis

A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by an inflammatory reaction in the glomerular capillaries due to the deposition of immune complexes and subsequent thickening of the glomerular basement membrane. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure.


acute urate nephropathy

Urolithiasis in which the composition of the stones is predominantly urate.


Congenital Nephrotic Syndrome - Focal Segmental Glomerulosclerosis

Nephrotic syndrome within the first three months of life, characterized by scarring of the glomerulus, in which only part of the glomerulus is involved, and less than 50% of the glomeruli are affected.


Ischemic nephropathy

Nephropathy due to hypoperfusion of the kidney.


Nephrotic Syndrome - Frequently Relapsing

Nephrotic syndrome in which there is relapse occurring two or more times in the first six months, or four or more times in a year.


Nephrotic Syndrome - Infrequently Relapsing

Nephrotic syndrome in which there is a relapse occurring less than twice in the first six months, or less than four times in a year.


Balkan nephropathy

A chronic tubulointerstitial nephropathy that affects people in certain rural areas along the Danube river in the Balkans. It leads to end-stage renal disease.


Nephrotic Syndrome - Hepatitis B Virus Associated

Nephrotic syndrome associated with hepatitis B.


nephrotic syndrome of childhood - steroid sensitive

Nephrotic syndrome, occurring in the pediatric population, characterized by the normalization of proteinuria with the administration of corticosteroids.


Arterionephrosclerosis

Scarring and atrophy of the renal cortex that occurs in hypertensive patients and in old age.


renal artery disease

A disease involving the renal artery.


Dent disease

Dent disease is a rare genetic renal tubular disease characterized by manifestations of proximal tubule dysfunction.


Nephropathy due to Cisplatin

Kidney damage resulting from cisplatin.


Membranous nephropathy associated with infectious disease.


cystinosis

Cystinosis is a metabolic disease characterized by an accumulation of cystine inside the lysosomes, causing damage in different organs and tissues, particularly in the kidneys and eyes. Three clinical forms have been described: nephropathic infantile, nephropathic juvenile and ocular.


Acute humoral allograft nephropathy

A sudden onset of B-cell mediated immune response occurring after transplantation, directed against donor kidney alloantigens.


Nephropathy Associated with Rhabdomyolysis

Nephropathy associated with rhabdomyolysis.


IgA Nephropathy, Infection-associated

IgA nephropathy co-occurring with infectious disease.


acute kidney tubular necrosis

Acute renal failure caused by the cell death of the renal tubules. Causes include nephrotoxins, cytotoxic drugs, and antibiotics.


Nephrotic Syndrome - LAMB2 Associated

Nephrotic syndrome attributed to mutation(s) in the LAMB2 gene.


Primary Focal Segmental Glomerulosclerosis

Focal scarring of the glomerulus, which may result in isolated proteinuria or nephrotic syndrome, which affects only part of the glomerulus and only some of the glomeruli. The condition is considered primary in cases for which no underlying cause has been identified.


autosomal recessive polycystic kidney disease

An inherited disorder characterized by the development of cysts affecting the collecting ducts. It is frequently associated with hepatic involvement.


Nephropathy due to Analgesic Drugs

Kidney damage resulting from analgesic drugs.


Complex renal cyst

A renal cyst characterized by epithelium lined space (squamous/columnar) with septations.


glomerular disorder

A disease involving the renal glomerulus.


C3 glomerulonephritis

Glomerulonephritis characterized by C3 accumulation with little or absent deposition of immunoglobulin, in the absence of ultrastructural electron-dense transformation seen in dense deposit disease.


polycystic kidney disease 1

Any autosomal dominant polycystic kidney disease in which the cause of the disease is a mutation in the PKD1 gene.


Nephrotic Syndrome - Cytomegalovirus Associated

Nephrotic syndrome associated with a cytomegalovirus infection.


Tip Lesion Glomerulopathy

Segmental glomerulopathy of localized intracapillary foam cells with adjacent, often vacuolated glomerular epithelial cells confluent to the origin of the proximal tubule.


Bone Marrow Transplantation Nephropathy

Kidney dysfunction resulting from complications of bone marrow transplantation.


Schistosomiasis Nephropathy

Kidney disease associated with Schistosoma infection. Injury to the kidney may be a result of immunologically mediated glomerular or interstitial injury and/or a result of reflux nephropathy.


acute diffuse glomerulonephritis

An acute inflammation of the glomeruli, in which all glomeruli are affected, resulting in acute renal failure.


Secondary focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis due to another medical condition.


Bisphosphonate - Induced Nephropathy

Kidney damage resulting from exposure to bisphosphonates.


Stage 2 chronic kidney disease

A type of chronic kidney disease with mildly reduced glomerular filtration rate (GFR 60-89 mL/min/1.73 m2).


nephronophthisis

Progressive tubulointerstitial injury, inherited in an autosomal recessive pattern, caused by mutations in genes involved in ciliary function, which may result in an end stage renal failure.


Nephrotic Syndrome - DGKE Associated

Nephrotic syndrome attributed to mutation(s) in the DGKE gene.


Nephrotic Syndrome - TRPC6 Associated

Nephrotic syndrome attributed to mutation(s) in the TRPC6 gene.


nephronophthisis 1

Progressive tubulointerstitial nephritis inherited in an autosomal recessive manner. It is caused by mutations in the NPHP1 gene. Patients present with anemia, polyuria, and polydipsia during childhood. The progressive bilateral kidney damage results in renal failure.


Calcineurin Nephrotoxicity

Kidney injury caused by calcineurin inhibitor immunosuppressive therapy which may lead to diminished kidney function.


Primary Collapsing Glomerulopathy

Collapsing glomerulopathy for which no underlying cause has been identified.


immunotactoid glomerulopathy

Immunotactoid glomerulopathy (ITG) is a very rare condition characterized by glomerular accumulation of microtubules in the mesangium and the glomerular basement membrane, that mainly presents with proteinuria, micro-hematuria, nephrotic syndrome, renal insufficiency and hematologic malignancy. ITG and non-amyloid fibrillary glomerulopathy (non-amyloid FGP) are often grouped together as pathogenetically related diseases.


Nephrotic Syndrome - LMX1B Associated

Nephrotic syndrome attributed to mutation(s) in the LMX1B gene.


Drug-induced Nephropathy

Kidney damage resulting from exposure to drugs.


Congenital Nephrotic Syndrome - Treponema Pallidum Associated

Nephrotic syndrome associated with syphilis, most commonly presenting in the first three months of life.


Radiation Nephropathy

Tissue damage to the glomerulus and renal tubules resulting from irradiation, which is characterized by vascular endothelial damage, mesangial damage, platelet aggregation in the capillary loops, thickening of the glomerular arteriolar intimal layer, and atrophic tubules.


Focal Segmental Glomerulosclerosis Collapsing Variant

A variant of FSGS characterized by glomerular tuft collapse, which may result in scarring. (D'Agati VD, et al. "Pathologic Classification of Focal Segmental Glomerulosclerosis: A Working Proposal." Am J Kidney Dis 43.2 (2004): 368-82.)


Inflammation of the glomeruli secondary to presence of autoantibodies directed at specific antigenic targets within the glomerular basement membrane, causing hematuria, proteinuria, and impaired renal function.


Focal Segmental Glomerulosclerosis Cellular Variant

A variant of FSGS characterized by hypercellularity of the glomerulus; this excludes the tip and collapsing FSGS. (D'Agati VD, et al. "Pathologic Classification of Focal Segmental Glomerulosclerosis: A Working Proposal." Am J Kidney Dis 43.2 (2004): 368-82.)


Membranous Nephropathy - Drug Associated

Membranous nephropathy associated with exposure to a drug.