Incidental Gallbladder Carcinoma

Gallbladder carcinoma that is discovered incidental to gallbladder surgery for another indication.


Grade 5 Leukoencephalopathy, CTCAE

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Death


Penile Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the penis.


Grade 3 Cecum or Appendix Hemorrhage, CTCAE


Sciatic Nerve Intra-Operative Injury, CTCAE


Grade 1 Tumor Pain, CTCAE

Mild pain


Advanced Esophageal Carcinoma

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Esophageal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Gastritis, CTCAE

Symptomatic; altered GI function; medical intervention indicated


Stage II Prostate Cancer AJCC v8

Stage II includes: IIA: (cT1a-c, cT2a, N0, M0, PSA equal or more than 10 and less than 20, Grade Group 1); (cT2b-c, N0, M0, PSA less than 20, Grade Group 1); IIB: T1-2, N0, M0, PSA less than 20, Grade Group 2; IIC: (T1-2, N0, M0, PSA less than 20, Grade Group 3); (T1-2, N0, M0, PSA less than 20, Grade Group 4). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. cT2b: Prostate cancer in which the tumor involves more than one-half of one side but not both sides. cT2c: Prostate cancer in which the tumor involves both sides. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


Grade 3 Urinary Tract Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 3 Periorbital Edema, CTCAE

Edema associated with visual disturbance; increased intraocular pressure, glaucoma or retinal hemorrhage; optic neuritis; diuretics indicated; operative intervention indicated


Colitis, CTCAE

A disorder characterized by inflammation of the colon.


Childhood Liver and Intrahepatic Bile Duct Neoplasm

A benign or malignant neoplasm of the liver parenchyma and intrahepatic bile ducts that occurs during childhood.


Grade 2 Dry Mouth, CTCAE

Moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min


Grade 4 Retina Intra-Operative Injury, CTCAE


Physical Examination Finding

The result of an evaluation of the body and its functions using visual inspection, palpation, percussion, or auscultation that is performed to determine the presence, absence, or degree of a condition.


Radiating Pain

A sensation of discomfort or distress that spreads from one anatomic location to another.


Grade 3 Personality Change, CTCAE

Severe personality change; hospitalization not indicated


Grade 1 Vertigo, CTCAE

Mild symptoms


Metastatic Bladder Large Cell Neuroendocrine Carcinoma

Bladder large cell neuroendocrine carcinoma that has spread to another anatomical site.


Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other

A rare type of primary cutaneous diffuse large B-cell lymphoma that does not belong in the group of primary cutaneous diffuse large B-cell lymphomas, leg type, or the group of primary cutaneous follicle center lymphomas.  It includes subtypes/entities of diffuse large B-cell lymphoma (e.g. intravascular large B-cell lymphoma, plasmablastic lymphoma, T-cell/histiocyte rich lymphoma) that can involve the skin as the primary anatomic site.  Such cases, unlike their nodal counterparts, usually have an excellent prognosis.


Grade 1 Insomnia, CTCAE

Mild difficulty falling asleep, staying asleep or waking up early


Grade 5 Ileum Stricture or Stenosis, CTCAE


Grade 2 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Surgical and Medical Procedures - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Fatigue, CTCAE

Fatigue relieved by rest


Metastatic ocular melanoma

Ocular melanoma that has spread from its original site of growth to another anatomic site.


Grade 1 Bronchial Stricture, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Hiccups, CTCAE

A disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm.


Grade 5 Vein Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Ventricular Tachycardia, CTCAE

Symptomatic, urgent intervention indicated


Grade 4 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Bruising in the Absence of Grade 3 or Grade 4 Thrombocytopenia, CTCAE


Grade 5 Intra-Abdominal Hemorrhage, CTCAE

Death


Grade 3 Pelvis Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Flashing Lights and Floaters in Vision, CTCAE


Cortical Cataract Grade 4

A stage of cortical cataract characterized by greater than 90% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Grade 2 Olfactory Nerve Disorder, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 2 Jejunal Perforation, CTCAE

Invasive intervention not indicated


Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8

Stage IIA includes: T1, N1, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Urethra Stricture or Stenosis, CTCAE


Low Grade Biliary Intraepithelial Neoplasia

Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial dysplasia.


Grade 3 Pharyngitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 4 Salivary Gland Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gallbladder Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Encephalopathy, CTCAE 5.0

A disorder characterized by a pathologic process involving the brain.


H-type congenital tracheoesophageal fistula

Congenital tracheoesophageal fistula without esophageal atresia.


Testicular Typical Seminoma

A testicular seminoma characterized by the presence of uniform round germ cells with glycogen-rich cytoplasm and large nuclei, and a lymphocytic infiltrate.


Grade 4 Laryngeal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., tracheotomy or intubation)


Grade 3 Cecal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 Salivary Gland Intra-Operative Injury, CTCAE


Non-Neoplastic Connective and Soft Tissue Disorder

A non-neoplastic disorder that affects the connective and soft tissue.


Grade 3 Extraocular Muscle Paresis, CTCAE

Bilateral paresis or unilateral paresis causing double vision in peripheral gaze, but not in central gaze


Peritoneal Pain

Painful sensation in the peritoneum.


Dental Caries, CTCAE

A disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous.


Neonatal Hypertension, AE

An adverse event in a newborn characterized by abnormally high blood pressure.


Grade 4 Hematuria, CTCAE

Life-threatening consequences; urgent invasive intervention indicated


Grade 2 Vestibular Disorder, CTCAE

Symptomatic; limiting instrumental ADL


Neoplasm by Morphology

A classification system grouping neoplasms according to their cellular characteristics.


Hypercalcemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood.


Grade 5 Laryngeal Hemorrhage, CTCAE

Death


Grade 2 Gastrointestinal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 4 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Small Bowel Perforation NOS, CTCAE


Edema Cerebral, CTCAE

A disorder characterized by swelling due to an excessive accumulation of fluid in the brain.


Grade 2 Scleral Necrosis and Melt, CTCAE


Grade 2 Dyspareunia, CTCAE

Moderate discomfort or pain associated with vaginal penetration; discomfort or pain partially relieved with use of vaginal lubricants or estrogen


Bladder Melanoma

A rare melanoma that arises from the bladder mucosa.


Grade 5 Central Nervous System Hemorrhage, CTCAE


Testosterone Deficiency, CTCAE

A disorder characterized by low testosterone.


Extranodal Lymphoma

A non-Hodgkin or Hodgkin lymphoma that arises from an anatomic site other than a lymph node.


Renal Radiation Injury

Radiation injury of the kidney.


Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Visceral Arterial Ischemia, CTCAE

A disorder characterized by a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery.


Non-Neoplastic Bladder Disorder

A non-neoplastic disorder that affects the urinary bladder. Representative examples include cystitis, cystolithiasis, and urinary bladder rupture.


Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Ampulla of Vater Intestinal-Type Adenocarcinoma

An invasive adenocarcinoma arising from the ampulla of Vater.  Morphologically, it is characterized by the presence of intestinal-type malignant epithelial cells.


Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Diffuse hyperplasia

Hyperplasia characterized by the presence of a diffuse cellular infiltrate.


Grade 2 Voice Changes and Dysarthria, CTCAE


Chronic Cancer Pain

Chronic pain that results from cancer and/or its treatment. The mechanism for chronic cancer pain may be  inflammatory, neuropathic, ischemic, and/or mechanical in nature.


Stage IIIB Appendix Carcinoma AJCC v8

Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Floaters, CTCAE

Limiting self care ADL


Grade 4 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Squamous cell carcinoma, microinvasive

A squamous cell carcinoma with minimal stromal invasion.


Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage III includes: (T2, N1, M0); (T3, N0-1, M0); (T4a, N0-1, M0). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IIIA includes: T0-2, N1, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Duodenal Perforation, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Vagina Intra-Operative Injury, CTCAE


Lower Extremity Intra-Operative Injury, CTCAE


Grade 3 Dry Eye, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Grade 5 Small Intestinal Obstruction, CTCAE

Death


Grade 5 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cervical Cancer by FIGO Stage 2018

A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2018.


Scalp Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the skin covering the top and the back of the head.


Grade 5 Small Bowel Perforation NOS, CTCAE


Grade 5 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


AIDS-Related Malignant Anal Neoplasm

A malignant neoplasm arising from the anus and occurring in HIV-positive patients.  Representative examples include squamous cell carcinoma and non-Hodgkin lymphoma.  Homosexual HIV-positive men have an increased risk of developing such malignancies in comparison to the general male population.


Testicular Hemorrhage, CTCAE

A disorder characterized by bleeding from the testis.


Hyperthyroidism, CTCAE

A disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose.


Grade 5 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Hypertension, CTCAE

Adult: Systolic BP 120-139 mm Hg or diastolic BP 80-89 mm Hg; Pediatric: Systolic/diastolic BP >90th percentile but< 95th percentile; Adolescent: BP >= 120/80 even if < 95th percentile


Grade 2 Photophobia, CTCAE

Limiting instrumental ADL


Refractory Malignant Endocrine Neoplasm

Malignant endocrine neoplasm that is resistant to treatment.


Nutritional Rickets

Rickets due to dietary deficiency of calcium, phosphate, or vitamin D.


Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Adenocarcinoma with metaplasia

An adenocarcinoma characterized by the presence of metaplasia.


Testis cancer recurrent

Malignant testicular germ cell tumor reemerging after a period of remission.


Grade 2 Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


Low Grade Cervical Squamous Intraepithelial Neoplasia

A precancerous neoplastic process that affects the cervical squamous epithelium without evidence of invasion. It is usually associated with human papillomavirus infection. It is characterized by the presence of mild atypia in the superficial epithelial layer that may be associated with koilocytosis. Maturation is present in the upper two thirds of the epithelium. Mitotic figures are not numerous and are present in the basal third of the epithelium.


Grade 2 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Gastric Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Lip Infection, CTCAE

Localized, local intervention indicated


Abdomen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Grade 2 Portal Vein Intra-Operative Injury, CTCAE


Pseudoangiomatous stromal hyperplasia

A benign proliferation of the stromal cells in the breast.  It is classified as simple, when associated with the presence of slit-like spaces without erythrocytes and as fascicular/proliferative, when spindle cell proliferation without atypia is present.  It is often seen in breast tissue specimens as small foci associated with benign epithelial lesions.  Pseudoangiomatous stromal hyperplasia presenting as a well-circumscribed palpable mass is rare.


Unresectable Malignant Solid Neoplasm

A malignant solid neoplasm that is not amenable to surgical resection.


Grade 5 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Crushing Pain

A sense of discomfort or distress that is squeezing or excessively compressing.


Grade 1 Ophthalmoplegia and Diplopia, CTCAE


Bladder Neuroendocrine Tumor

A well-differentiated neuroendocrine neoplasm arising from the bladder. It is characterized by the presence of uniform cells with stippled chromatin and inconspicuous nucleoli. Mitotic activity is low and tumor necrosis is absent.


Stage I Prostate Cancer AJCC v8

Stage I includes: (cT1a-c, cT2a, N0, M0, PSA less than 10, Grade Group 1); (pT2, N0, M0, PSA less than 10, Grade Group 1). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. pT2: Prostate cancer which is organ confined. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. (AJCC 8th ed.)


Injection Site Reaction, CTCAE

A disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection.


Grade 3 Jejunal Perforation, CTCAE

Invasive intervention indicated


Grade 2 Colon or Cecum or Appendix Fistula, CTCAE


Grade 3 Esophagus Stricture or Stenosis, CTCAE


Grade 2 Tracheostomy Site Bleeding, CTCAE

Moderate bleeding; medical intervention indicated


Unresectable Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction adenocarcinoma that is not amenable to surgical resection.


Recurrent Anaplastic Ependymoma

The reemergence of anaplastic ependymoma after a period of remission.


Grade 1 Neutrophils and Granulocytes, CTCAE


Grade 2 Hypoparathyroidism, CTCAE

Moderate symptoms; medical intervention indicated


Grade 5 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


The presence of bacteria in the blood caused by an infected hemodialysis catheter.


Grade 3 Pancreatitis, CTCAE

Severe pain; vomiting; medical intervention indicated (e.g., analgesia, nutritional support)


Monoclonal Polymorphic Post-Transplant Lymphoproliferative Disorder


Grade 2 Neonatal Constipation, AE

An adverse event in a newborn characterized by reduced number of stools or hard stools; apparent discomfort; minor care changes indicated.


Grade 3 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Cranial Nerve III Neuropathy, CTCAE


Grade 3 Tracheal Stenosis, CTCAE

Stridor or respiratory distress limiting self care ADL; invasive intervention indicated (e.g., stent, laser)


Grade 1 Peripheral Motor Neuropathy, CTCAE

Asymptomatic; clinical or diagnostic observations only


Metastatic Carcinoma in the Pancreas

A carcinoma that has spread to the pancreas from another anatomic site.


Grade 3 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Grade 2 Edema of the Head and Neck, CTCAE


Refractory Low Grade Astrocytoma

Low grade astrocytoma that is resistant to treatment.


Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Pelvic Pain, CTCAE

Mild pain


Grade 4 Bladder Intra-Operative Injury, CTCAE


Grade 1 Vas Deferens Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Salivary Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IV Renal Pelvis and Ureter Cancer AJCC v8

Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat. N0: No regional lymph node metastasis. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm in greatest dimension; or multiple lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


TNFRSF8 Low

Indicates that low expression of TNFRSF8 has been detected in a sample.


Ampulla of Vater Neuroendocrine Tumor

A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region.


Posterior Fossa Ependymoma, Not Otherwise Specified

A circumscribed ependymoma that arises in the posterior fossa in which molecular analysis for DNA methylation profiling was unsuccessful or not reported.


Locally Advanced Prostate Adenocarcinoma

A prostatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Metastases to abdominal cavity

The spread of a malignant neoplasm from a primary site to an unspecified organ in the abdominal cavity.


Vulval Infection, CTCAE

A disorder characterized by an infectious process involving the vulva.


Grade 1 Pharyngeal Anastomotic Leak, CTCAE


Grade 3 Vasovagal Reaction, CTCAE

Present


Conjunctival Oncocytoma

A benign epithelial neoplasm that arises from the conjunctiva. It is characterized by the presence of oncocytic cells with abundant eosinophilic and granular cytoplasm.


Grade 2 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Blood Corticotrophin Decreased, CTCAE

Symptomatic; medical intervention indicated


Grade 4 Sacral Plexus Intra-Operative Injury, CTCAE


Maternal Hemorrhage

Uncontrolled bleeding from a pregnant or a woman who has recently given birth.


Rash Maculo-Papular, CTCAE

A disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritis.


Grade 2 Oral Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 5 Salivary Gland Infection, CTCAE

Death


Advanced Malignant Skin Neoplasm

A malignant neoplasm of the skin that has spread extensively to other anatomic sites or is no longer responding to treatment.


Pancreatic Alpha Cell Adenoma

A benign endocrine neoplasm arising from the alpha cells of the pancreas.  It produces glucagon.


Grade 5 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Lugano Classification Advanced Stage Hodgkin Lymphoma AJCC v8

Advanced stage Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Stage IIA Ampulla of Vater Cancer AJCC v8

Stage IIA includes: T3a, N0, M0. T3a: Tumor directly invading the pancreas (up to 0.5 cm). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Uterine Perforation, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Depressed Level of Consciousness, CTCAE

Difficult to arouse


Stage IVB Vulvar Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


Grade 4 Central Nervous System Necrosis, CTCAE


Stage III Lentigo Maligna Melanoma AJCC v7

Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Reproductive Endocrine Neoplasm

A benign or malignant endocrine neoplasm that arises from the testis or the ovary.


Grade 5 Eye Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Anemia due to Decreased Production

Anemia that results from a decreased rate of erythropoiesis.


Melanoma Metastatic in the Central Nervous System

A melanoma that has spread to the central nervous system from its original site of growth, through the hematogenous route.


Grade 3 Lymphocyte Count Decreased, CTCAE

<500-200/mm3; <0.5-0.2 x 10e9/L


Domestic injury

Trauma occurring within the confines of the home environment.


Grade 3 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


GGT Increased, CTCAE

A finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water.


Grade 3 Intracranial Hemorrhage, CTCAE

Ventriculostomy, ICP monitoring, intraventricular thrombolysis, or invasive intervention indicated; hospitalization


Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Extragonadal primary germ cell tumor mixed stage I


Grade 2 Skin Intra-Operative Injury, CTCAE


Neck Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 5 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Aortic Injury, CTCAE

Death


Increased Concomitant Drug AUC

Increased area under the plot of plasma concentration of a concomitant drug against time after its administration.


Grade 4 Laryngopharyngeal Dysesthesia, CTCAE

Life-threatening consequences


Grade 1 Esophagus Intra-Operative Injury, CTCAE


Grade 5 Neonatal Culture Positive Sepsis, AE

A culture positive sepsis adverse event in a newborn which results in death.


Grade 5 Pharyngeal Stenosis, CTCAE

Death


Grade 4 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Neonatal Coagulation Disorder, AE

An adverse event in a newborn characterized by biochemical or clinical coagulation abnormalities; requiring intervention.


Grade 5 Injury To Carotid Artery, CTCAE

Death


Grade 3 Lip Pain, CTCAE

Severe pain; limiting self care ADL


Neonatal Sinus Tachycardia, AE

An adverse event in a newborn characterized by an abnormally high heart rate for age.


Stage IB Vulvar Cancer AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Lesion measuring more than 2 cm, or any size with stromal invasion of more than 1.0 mm, confined to the vulva and/or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


Grade 1 Other Sexual Reproductive Function, CTCAE


Grade 2 Prostatic Obstruction, CTCAE

Symptomatic; elective intervention indicated


Grade 3 Colon or Cecum or Appendix Necrosis, CTCAE


Stage IIA Pancreatic Cancer AJCC v8

Stage IIA includes: T3, N0, M0. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Lower Extremity Artery Intra-Operative Injury, CTCAE


Grade 1 Extraocular Muscle Paresis, CTCAE

Asymptomatic; clinical or diagnostic observations only


Clonal Hematopoiesis of Indeterminate Potential

A term that refers to the presence of somatic mutations in bone marrow or peripheral blood cells in individuals who may be cytopenic but do not have morphologic evidence of hematologic neoplasia. Its prevalence rises with age and is found in approximately 10% of individuals aged 70 to 80. It is associated with an increased risk of hematologic neoplasia. Mutations in the DNMT3A, TET2, or ASXL1 genes are usually identified. Approximately 10%-40% of individuals with age-related clonal hematopoiesis will progress to meet the diagnostic criteria for clonal hematopoiesis of indeterminate potential.


Grade 4 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Vagina Intra-Operative Injury, CTCAE


Blood Cardiac Troponin Increased

A laboratory test result which indicates increased levels of cardiac troponin in a biological specimen.


Pleural fistula

An abnormal communication between the pleural cavity and another anatomic site.


Grade 3 Lung Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 5 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Spermatic Cord Hemorrhage, CTCAE

A disorder characterized by bleeding from the spermatic cord.


Refractory Fibrosarcoma

Fibrosarcoma that is resistant to treatment.


Substance-Induced Anxiety Disorder

An anxiety disorder in which the symptoms of anxiety have been determined to be etiologically related to the direct physiological effects of a substance (i.e., a drug of abuse, a medication, or toxin exposure).


Grade 1 Hypoglycemia, CTCAE

<LLN-55 mg/dL; <LLN-3.0 mmol/L


Hodgkin's disease lymphocyte predominance type recurrent

An antiquated term that refers to the reemergence of either nodular lymphocyte predominant Hodgkin lymphoma or lymphocyte-rich classical Hodgkin lymphoma after a period of remission.


Clinical Stage I Esophageal Adenocarcinoma AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Rectal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 2 Sneezing, CTCAE

Moderate symptoms; medical intervention indicated


Stage IIIC Fallopian Tube Cancer AJCC v8

Stage IIIC includes: T3c, N0/N1, M0. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Grade 3 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Vascular hemorrhagic disorders

A hemorrhagic disorder that is caused by pathologic changes in the vasculature.


Grade 1 Seizure, CTCAE

Brief partial seizure and no loss of consciousness


Grade 4 Nasal Cavity Intra-Operative Injury, CTCAE


Grade 5 Myocarditis, CTCAE

Death


Pregnancy Mood Swing

The fluctuations in the mental and emotional state of an individual during pregnancy.


Adverse Event Associated with Death

An adverse event resulting in death.


Peripheral Vascular Insufficiency

A condition in which there is inadequate blood flow through the peripheral blood vessels due to intrinsic disease of the vasculature.


Rash and Dermatitis Associated with Radiation Excluding Chemoradiation, CTCAE


Grade 4 Upper Airway NOS Intra-Operative Injury, CTCAE


Child Intoxication With Breast Implant Material Ingredients

Children affected by toxins may be due to silicone breast implants and their effects on unborn children and from breastfeeding.


Grade 2 Edema Trunk, CTCAE

Readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental ADL


Grade 5 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Grade 5 Mucositis Oral, CTCAE

Death


Grade 1 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Amnestic disorders due to a general medical condition

A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the direct physiological consequence of a general medical condition. The memory impairment is not the result of a delirium or dementia.


Advanced Gastric Small Cell Neuroendocrine Carcinoma

A gastric small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Endocrine Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Intraoperative Cardiac Injury, CTCAE

Primary repair of injured organ/structure indicated


Eczema, CTCAE

A disorder characterized by skin which becomes itchy, red, inflamed, crusty, thick, scaly, and/or forms blisters.


Subdural Hemorrhage Related to Birth

Bleeding within the subdural space occurring during labor and/or delivery.


Grade 4 Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pancreatic Mucinous-Cystic Neoplasm, Low Grade

A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of mild dysplasia and absence of mitotic figures.


Hereditary coagulation factor deficiency

An inherited blood coagulation disorder characterized by deficiency of one of the coagulation factors, resulting in bleeding.


Grade 1 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 5 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Fibrinogen Decreased, CTCAE

<0.25 x LLN; if abnormal, 75% decrease from baseline; absolute value <50 mg/dL


Grade 3 Hemorrhage and Bleeding, CTCAE Associated with Surgery, CTCAE


Myelofibrosis due to another disorder

Myelofibrosis that develops in patients with a history of hematologic malignancies or toxic injury to the bone marrow.


Grade 4 Spasticity, CTCAE

Life-threatening consequences; unable to move active or passive range of motion


Astler-Coller A Colon Carcinoma

Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Prostate Ductal Adenocarcinoma, Papillary Pattern

A prostate ductal adenocarcinoma characterized by the presence of a papillary growth pattern.


Grade 1 Aortic Valve Disease, CTCAE

Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging


Grade 2 Dizziness, CTCAE

Moderate unsteadiness or sensation of movement; limiting instrumental ADL


Pathologic Stage 0 Esophageal Adenocarcinoma AJCC v8

Stage 0 includes: Tis, N0, M0, GN/A. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. GN/A: Grade non-applicable. (AJCC 8th ed.)


Grade 5 Hypermagnesemia, CTCAE

Death


Grade 2 Infusion Site Extravasation, CTCAE

Erythema with associated symptoms (e.g., edema, pain, induration, phlebitis)


Early Favorable Hodgkin Lymphoma

An early Hodgkin lymphoma with favorable prognosis.


Grade 5 Neonatal Pneumothorax, AE

A pneumothorax adverse event in a newborn which results in death.


Grade 2 Salivary Gland Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Spinal Fracture, CTCAE

A finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken.


Facial Muscle Weakness, CTCAE

A disorder characterized by a reduction in the strength of the facial muscles.


Jejunal Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the jejunum.


Grade 5 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Non-Neoplastic Chronic Respiratory System Disorder

A non-neoplastic longstanding disorder of the respiratory system.


Stage IV Prostate Cancer AJCC v8

Stage IV includes: IVA: Any T, N1, M0, PSA: Any, Grade Group: Any; IVB: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. N1: Prostate cancer with metastases in regional node(s). M0: Prostate cancer without evidence of distant metastasis. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Monoclonal Paraproteinemia Present in Lower than Myeloma Levels

An indication that the detected amount of monocolonal paraproteinemia in a sample is lower than the range of levels that are associated with myeloma.


Human immunodeficiency virus leukoencephalopathy


Childhood Kidney Disorder

A kidney disorder that appears during childhood.


Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic carcinoid tumor

A carcinoid tumor that has extended beyond its original site of growth to other anatomic sites.


Grade 2 Hyperglycemia, CTCAE

Change in daily management from baseline for a diabetic; oral antiglycemic agent initiated; workup for diabetes


Grade 5 Anal Hemorrhage, CTCAE

Death


Grade 1 Thrombotic Microangiopathy, CTCAE


Grade 4 Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Phrenic Nerve Dysfunction, CTCAE


Emotional problems

A perceived issue with a person's emotional wellbeing.


Grade 4 Rectal Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Concentration Impairment, CTCAE

Moderate impairment in attention or decreased level of concentration; limiting instrumental ADL


Grade 2 Bile Duct Stenosis, CTCAE

Symptomatic; altered GI function; IV fluids indicated <24 hrs


Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Clear cell tumor

A purely morphologic term that describes a neoplasm in which all or the majority of the neoplastic cells have a clear cytoplasm, when examined under light microscopy, using the conventional staining method (H-E). This term does not provide any information about the nature of the neoplasm (benign or malignant), cell of origin (e.g. epithelial versus mesenchymal versus hematopoietic), or prognosis. Further examination using special stains and/or immunohistochemistry is required to appropriately classify this tumor.


High-CSD Melanoma

A finding indicating a high degree of cumulative sun damage in the skin as evidenced by severe solar keratosis. (WHO 2018)


Recurrent Malignant Endocrine Neoplasm

Reemergence of a malignant endocrine neoplasm after a period of remission.


Anemia due to disorders of nucleotide metabolism

A group of hemolytic anemias that result from either the deficiency or overproduction of several enzymes involved in metabolizing nucleotides.


Hyperlipidemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of lipids in blood.


Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Rectal Fissure, CTCAE

Invasive intervention indicated


Metastatic Neuroendocrine Tumor

A neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma by AJCC v8 Stage

A term that refers to the staging of adrenal gland pheochromocytoma and sympathetic paraganglioma, following the rules of the TNM AJCC v8 classification system. Parasympathetic paragangliomas are not staged because they are largely benign. This staging system does not apply to neuroendocrine tumors of the pancreas (are staged according to the classification for neuroendocrine tumors of the pancreas) and carotid body tumors (not staged). (from AJCC 8th Ed.)


Abnormal Phenolsulfonphthalein Test Result

A laboratory test result indicating other than normal parameters after a phenolsulfonphthaliein test.


Recurrent Retinoblastoma

The reemergence of retinoblastoma after a period of remission.


Radiation injury of bone marrow

Radiation injury of the hematopoietic system.


Grade 4 Cranial Nerve X Neuropathy, CTCAE


Invasive Malignant Neoplasm

Cancer that has spread beyond the layer of tissue in which it developed and is growing into surrounding, healthy tissues.


Grade 4 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Chronic Myelomonocytic Leukemia with Eosinophilia

A chronic myelomonocytic leukemia characterized by a peripheral blood eosinophil count of equal or greater than 1.5x10E9/L, and absence of PDGFRA or PDGFRB gene abnormalities.


Advanced Platinum-Resistant Malignant Germ Cell Tumor

A platinum-resistant malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Esophageal Obstruction, CTCAE

Hospitalization indicated; invasive intervention indicated; limiting self care ADL


Grade 4 Ovarian Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IIIB Fallopian Tube Cancer AJCC v8

Stage IIIB includes: T3b, N0/N1, M0. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Grade 1 Ileum Intra-Operative Injury, CTCAE


Ampulla of Vater Invasive Papillary Adenocarcinoma

An invasive adenocarcinoma that arises from an exophytic papillary neoplasm of the ampulla of Vater.


Grade 5 External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IVC Appendix Carcinoma AJCC v7

Stage IVC includes: Any T, Any N, M1b, Any G.  M1b: Nonperitoneal metastasis.  (AJCC 7th ed.)


Grade 4 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Grade 4 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Myelitis, CTCAE

Moderate weakness or sensory loss; limiting instrumental ADL


Grade 3 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Repeat Expansion Disease

A class of genetic diseases that occur when microsatellite repeats expand beyond a threshold length.


Anal Adenocarcinoma within Anorectal Fistula

An anal adenocarcinoma arising from the lining of an anorectal fistulous tract.  The overlying anal mucosa does not show evidence of neoplastic changes.  Some cases are associated with Crohn disease.


Hemorrhage and Bleeding Associated with Surgery, CTCAE


Stage IA Cutaneous Melanoma AJCC v7

Stage IA includes: T1a, N0, M0.  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and with mitosis less than 1/mm2.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 3 Phantom Pain, CTCAE

Severe pain; limiting self care ADL


Grade 3 Abdominal Distension, CTCAE

Severe discomfort; limiting self care ADL


Stage IA Fallopian Tube Cancer AJCC v6 and v7

Stage IA includes: T1a, N0, M0. T1a: Tumor limited to one tube, without penetrating the serosal surface; no ascites.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Benign Infratentorial Neoplasms

A benign neoplasm that occurs in the infratentorial region.


Grade 4 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute Lymphoblastic Leukemia by Gene Expression Profile

Gene expression-based patient cluster groups in acute lymphoblastic leukemia.


Grade 1 Vagina Stricture or Stenosis, CTCAE


Grade 5 Peripheral Ischemia, CTCAE

Death


Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Alkalosis, CTCAE

Death


Composite paraganglioma

A neoplasm that combines morphologic characteristics of paraganglioma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor.


Grade 2 Glomerular Filtration Rate, CTCAE


Recurrent pyogenic cholangitis

A recurrent form of cholangitis that is characterized by intrabiliary pigment stone formation, biliary tree stricture and obstruction, and recurrent bouts of cholangitis. There is an association with biliary parasitosis, but evidence supporting these infections in the pathogenesis of recurrent pyogenic cholangitis is inconclusive. The most common causes of death are sepsis, liver failure, or complications from cirrhosis. Patients are also at increased risk of cholangiocarcinoma.


Grade 3 Pharyngeal Stenosis, CTCAE

Limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)


Grade 3 Lower Extremity Vein Intra-Operative Injury, CTCAE


Stage II Ampulla of Vater Cancer AJCC v8

Stage II includes: IIA: T3a, N0, M0; IIB: T3b, N0, M0. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Sex Chromosome Differences of Sex Development

A condition affecting gonadal and/or internal and/or external reproductive/genital development in which there is an atypical number of sex chromosomes (i.e. fewer or greater than the typical 2 X chromosomes or 1 X and 1 Y chromosome).


Germinative Follicular Epithelium Neoplasm

A neoplasm involving the germinative follicular epithelium.


Infectious disease of genitourinary system

An acute or chronic infectious process affecting any part of the genitourinary system.


Grade 1 Urinary Electrolyte Wasting, CTCAE


Grade 4 Pancreatic Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Mixed Failure to Thrive

Failure to thrive due to both organic and non-organic causes.


Dysgeusia, CTCAE

A disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell.


Grade 1 Urinary Tract NOS Intra-Operative Injury, CTCAE


PSA Level Finding

A finding that indicates the amount of prostate specific antigen in a sample.


Wound Complication, CTCAE

A finding of development of a new problem at the site of an existing wound.


Grade 5 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Fever Without Neutropenia, CTCAE


Grade 1 Dry Skin, CTCAE

Covering <10% BSA and no associated erythema or pruritus


Stage IV Lentigo Maligna Melanoma AJCC v6 and v7

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


Grade 1 Other Growth and Development, CTCAE


Pediatric Infectious Disorder

An infectious disorder that occurs during infancy, childhood, or adolescence.


Hypothalamic Cancer

A primary or metastatic malignant neoplasm that affects the hypothalamus.


Hypergranular promyelocytic leukemia

Acute Promyelocytic leukemia characterized by the presence of hypergranular promyelocytes and characteristic cells that contain bundles of Auer rods.


Grade 2 Oropharyngeal Pain, CTCAE

Moderate pain; altered oral intake; non-narcotics initiated; topical analgesics initiated


Grade 4 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Cholesterol High, CTCAE

>500 mg/dL; >12.92 mmol/L


Grade 1 Pulmonary Valve Disease, CTCAE

Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging


Primary cutaneous CD30 antigen positive T-cell lymphoproliferative disorder

This entity represents a spectrum of lymphoproliferative disorders characterized by CD30 (Ki-1)-positive cutaneous T-cell infiltrates.  The two ends of the spectrum include lymphomatoid papulosis (benign end) and primary cutaneous anaplastic large cell lymphoma (malignant end).  Borderline lesions are also included in this spectrum.  (WHO, 2001)


Non-Hodgkin's Lymphoma, Lymphoblastic (WF)


Grade 3 Intraoperative Hepatobiliary Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 5 Cystitis Noninfective, CTCAE

Death


Solder Fume Exposure

Environmental, occupational, or consumer-based exposure to vaporized materials during the soldering process.


Grade 4 Prolapse of Gastrointestinal Stoma, CTCAE


Stage IVB Gallbladder Cancer AJCC v8

Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1). N2: Metastases to four or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Grade 2 Esophagus Intra-Operative Injury, CTCAE


Localized Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

An undifferentiated high grade pleomorphic sarcoma of bone that occurs in childhood and has not spread to other anatomic sites.


Grade 3 Hematuria, CTCAE

Gross hematuria; transfusion, IV medications, or hospitalization indicated; elective invasive intervention indicated; limiting self care ADL


Grade 1 Fall, CTCAE

Minor with no resultant injuries; intervention not indicated


Locally Advanced Pancreatic Neuroendocrine Carcinoma

A pancreatic neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Nodal or Junctional Rhythm, CTCAE


Grade 3 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


Yolk Sac Tumor with Somatic-Type Malignancy

A yolk sac tumor that is characterized by morphologic transformation to somatic-type malignancy. The somatic-type malignant component most often is sarcomatous or carcinomatous.


Grade 4 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intraepithelial Melanocytic Hyperplasia

A hyperplasia of the intraepithelial melanocytes.


Grade 1 Stomach Stricture or Stenosis, CTCAE


FIGO Stage IVC Gestational Trophoblastic Tumor


Childhood Gastric Carcinoma

A rare carcinoma of the stomach that occurs during childhood.


Phlebitis Including Superficial Thrombosis, CTCAE


Grade 2 Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Superior Vena Cava Syndrome, CTCAE

Severe symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting)


Stage IV Gallbladder Cancer AJCC v6

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.)


Grade 3 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Native valve endocarditis

Endocarditis affecting a native valve of the heart.


Benign germ cell neoplasm

A germ cell tumor without metastatic potential.


Pleural Infection

An infectious process affecting the pleura.


Stage II Uterine Corpus Cancer

Stage II includes: T2, N0, M0.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  Endocervical glandular involvement only should be considered as Stage I and not as Stage II.  N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Esophageal Hodgkin Lymphoma

A very rare Hodgkin lymphoma that arises from the esophagus.


Refractory Vaginal Carcinoma

Vaginal carcinoma that does not respond to treatment.


Grade 4 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Grade 2 Hypoxia, CTCAE

Decreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen


Verumontanum Mucosal Gland Hyperplasia

A benign microacinar proliferation occurring exclusively in the verumontanum and adjacent posterior urethra where the ejaculatory ducts and utricle empty into the urethra. Crystalloids and intraluminal mucin are usually absent, but; intraluminal corpora amylacea are often present. The lining epithelium typically consists of bland cuboidal to columnar luminal cells with underlying basal cells.


Unresectable Fallopian Tube Endometrioid Adenocarcinoma

Fallopian tube endometrioid adenocarcinoma that is not amenable to surgical resection.


Grade 2 Genitourinary Stoma Prolapse, CTCAE


Salivary Gland Infection, CTCAE

A disorder characterized by an infectious process involving the salivary gland.


Grade 3 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pelvis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Vascular Access Graft Failure

Failure to achieve vascular access due to damage of the graft that was created for this purpose.


Grade 1 Muscle Weakness Right-Sided, CTCAE

Symptomatic; perceived by patient but not evident on physical exam


Anal Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the anal region.


Grade 1 Upper Extremity Artery Injury, CTCAE


Retinal Vascular Disorder, CTCAE

A disorder characterized by pathological retinal blood vessels that adversely affects vision.


Recurrent Adult Diffuse Large Cell Lymphoma

The reemergence of adult diffuse large cell lymphoma after a period of remission.


Grade 1 Transient Ischemic Attacks, CTCAE

Mild neurologic deficit with or without imaging confirmation


Benign Anal Granular Cell Tumor

A non-metastasizing neoplasm arising from the anus.  It is characterized by the presence of large polygonal cells with abundant granular cytoplasm.


Grade 4 Vision Decreased, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Acquired Facial Nerve Palsy

A condition characterized by reduced or absent movement of the ipsilateral face as a consequence of an injury to the seventh cranial nerve that has occurred after birth.


Grade 5 Pulmonary Edema, CTCAE

Death


Unresectable Fibrosarcoma

A fibrosarcoma that is not amenable to surgical resection.


Central line complication

A problem with a central venous access catheter or site of insertion.


Grade 4 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Urinary Tract Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the urinary tract.


Beta Thalassemia Plus Structural Variants

A heterozygous state in which a person has a mutation in a beta globin allele causing beta thalassemia, together with other structural variants in the other allele.


Esthesioneurocytoma

A rare benign neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity. Microscopically, it is characterized by the absence of malignant characteristics and the absence of rosettes formation.


Small Intestinal Mucositis, CTCAE

A disorder characterized by ulceration or inflammation of the mucous membrane of the small intestine.


Recurrent Primary Amyloidosis

The reemergence of primary amyloidosis after a period of remission.


Transitional cell carcinoma metastatic

A carcinoma that arises from transitional cells and has spread from its original site of growth to another anatomic site.


Grade 3 Radiation Recall Reaction (Dermatologic), CTCAE

Moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion


Grade 2 Esophageal Varices Hemorrhage, CTCAE

Self-limited; intervention not indicated


Asystole, CTCAE 5.0

A disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart.


Grade 3 Apnea, CTCAE

Present; medical intervention indicated


Neonatal Gastrointestinal Bleeding, AE

An adverse event in a newborn characterized by hemorrhage originating at any site located within the gastrointestinal tract.


Grade 2 Neuroendocrine ADH Secretion Abnormality, CTCAE


Grade 2 Blood Antidiuretic Hormone Abnormal, CTCAE

Symptomatic; medical intervention indicated


Non-Neoplastic Peritoneal Disorder

A non-neoplastic disorder that affects the peritoneum. Representative examples include peritonitis and panniculitis.


Inherited neuropathies

A hereditary disorder that affects the sensory and/or motor nerves or the autonomic nerves.


Grade 2 Thoracic Duct Intra-Operative Injury, CTCAE


Skin Reaction Secondary to Radiation Therapy


Intracranial Laceration Related to Birth

Tearing of the cerebral or cerebellar parenchyma or vessels of a newborn infant due to forces occurring during labor and delivery.


Grade 1 Hypernatremia, CTCAE

>ULN-150 mmol/L


Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8

Stage IIIA includes: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Grade 1 Pituitary Intra-Operative Injury, CTCAE


Grade 3 Pancreatic Enzymes Decreased, CTCAE

Sequelae of absorption deficiency


Grade 3 Esophagitis, CTCAE

Severely altered eating/swallowing; tube feeding, TPN, or hospitalization indicated


Fracture, CTCAE

A finding of traumatic injury to the bone in which the continuity of the bone is broken.


Grade 1 Intraoperative Musculoskeletal Injury, CTCAE

Primary repair of injured organ/structure indicated


Tumor Mass of the Extremity

A mass-forming benign or malignant neoplasm that affects a limb of the body.


Esophageal Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The Ki-67 index is higher than 20%.


Grade 2 Tendon Intra-Operative Injury, CTCAE


Grade 1 Female Genital Tract Fistula, CTCAE


Grade 1 Pleural Hemorrhage, CTCAE

Asymptomatic; mild hemorrhage confirmed by thoracentesis


Advanced Malignant Germ Cell Tumor

A malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Endometrial Carcinoma

Endometrial carcinoma that is not amenable to surgical resection.


intraductal papillary-mucinous neoplasm of pancreas with moderate dysplasia

A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that exhibit nuclear stratification, loss of polarity, and crowding.  There is moderate nuclear hyperchromasia.


Aplastic anemia due to infection

Aplastic anemia caused by an infection.


Grade 3 Keratitis, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); corneal ulcer; limiting self care ADL


Otitis Media, CTCAE

A disorder characterized by an infectious process involving the middle ear.


Grade 5 Neonatal Fever, AE

A febrile adverse event in a newborn which results in death.


Grade 2 Rectal Obstruction, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Esophageal High Grade Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal mucosa.  It includes lesions termed moderate dysplasia, and carcinoma in situ (severe dysplasia).  (WHO, 2000)


Grade 4 Vasculitis, CTCAE

Life-threatening consequences; evidence of peripheral or visceral ischemia; urgent intervention indicated


Advanced Primary Malignant Brain Neoplasm

A malignant neoplasm that arises from the brain and has spread extensively or is no longer responding to treatment.


Stage IIIB Fallopian Tube Cancer AJCC v7

Stage IIIB includes: T3b, N0, M0.  T3b: Macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Ileal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 CNS Cerebrovascular Ischemia, CTCAE


Pathologic Stage I Esophageal Adenocarcinoma AJCC v8

Stage I includes: IA: (T1a, N0, M0, G1); (T1a, N0, M0, GX); IB: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX); IC: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Neoplasm by Special Category

A neoplasm defined by its unique characteristic as they apply to clinical presentation and course, morphologic patterns, frequency, and/or age distribution.


Grade 3 Laryngeal Edema, CTCAE

Stridor; respiratory distress; hospitalization indicated


Grade 5 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Upper Gastrointestinal Hemorrhage, CTCAE

A disorder characterized by bleeding from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach).


Grade 3 Superior Vena Cava Vein Injury, CTCAE


Vomiting, CTCAE

A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth.


Grade 2 International Normalized Ratio of Prothrombin Time, CTCAE


Grade 4 Colonic Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Hypoalbuminemia, CTCAE

<3-2 g/dL; <30-20 g/L


Localized Gastric Carcinoma

A carcinoma that arises from the stomach and has not spread to other anatomic sites.


Uterine Ligament Wolffian Tumor

An epithelial neoplasm of Wolffian (mesonephric) origin arising from a uterine ligament. Most tumors behave in a benign fashion.


Grade 5 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Retrobulbar Hemorrhage

Bleeding in the orbital cavity that results in compression of orbital structures, resulting in ischemia of the optic nerve, and possible loss of vision.


Grade 1 Aspiration, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Transient Hyperinsulinism

Hyperinsulinism that resolves spontaneously. This is the most common cause of neonatal hypoglycemia.


Recurrent Malignant Solid Neoplasm

A malignant solid neoplasm that has recurred after a period of remission.


Chronic Decubitus

A longstanding lesion caused by death of tissue due to external pressure.


Sinusoidal hemangioma

A rare hemangioma occurring mainly in middle-aged adults. The most common location is in the trunk. The lesions are small, asymptomatic, and bluish. They are composed of irregular, dilated, congested thin-walled vascular channels with scant smooth muscle in a sinusoidal or sieve-like pattern. (WHO 2018)


Stage IB Cervical Cancer AJCC v9

Stage IB includes: T1b, N0, M0. T1b: Tumor with measured deepest invasion more than 5 mm (greater than FIGO stage IA); lesion limited to the cervix uteri with size measured by maximum tumor diameter. Note: The involvement of vascular/lymphatic spaces should not change the staging. The lateral extent of the lesion is no longer considered. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Febrile Neutropenia without Clinically or Microbiologically Documented Infection with Absolute Neutrophil Count Less Than 1 X 10e9 per Liter and Temperature Greater Than or Equal to 38 Point 5 Degrees Celsius, CTCAE


Grade 3 Atrial Fibrillation, CTCAE

Symptomatic, urgent intervention indicated; device (e.g., pacemaker); ablation; new onset


Grade 1 Cervical Spine Range of Motion, CTCAE


General Disorders and Administration Site Conditions - Other, Specify, CTCAE


Stage IVB Cervical Cancer AJCC v6 and v7

Stage IVB includes: Any T, Any N, MI. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Stage IIIC Gastric Cancer AJCC v7

Stage IIIC includes: (T4b, N2, M0); (T4b, N3, M0); (T4a, N3, M0).  T4a: Tumor invades serosa (visceral peritoneum).  T4b: Tumor invades adjacent structures. N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Killing Pain

A sensation of extreme discomfort and anguish that is perceived as severe enough to cause one's death.


Grade 2 Stoma Pulmonary Hemorrhage, CTCAE


Grade 2 Other Musculoskeletal and Soft Tissue, CTCAE


Metastatic Pancreatic Ductal Adenocarcinoma

An adenocarcinoma that arises from the exocrine pancreatic ducts and has metastasized to other anatomic sites.


Grade 1 Bullous Dermatitis, CTCAE

Asymptomatic; blisters covering <10% BSA


Grade 2 Glossopharyngeal Nerve Disorder, CTCAE

Moderate symptoms; limiting instrumental ADL


CTCAE v4 Grade 2

An adverse event for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated; or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances).


Hematologic Malignancy-Associated Skin Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the skin in a patient with a history of hematologic malignancy, usually non-Hodgkin lymphoma or chronic lymphocytic leukemia.


Metastatic Carcinoma to the Uterine Cervix

A carcinoma that has spread to the cervix from another anatomic site.


Conjunctival foreign body

External material in or on the conjunctiva.


Gum Infection, CTCAE

A disorder characterized by an infectious process involving the gums.


A high grade poorly differentiated carcinoma arising from the digestive system.  It is composed of small or large neoplastic cells that express immunohistochemical evidence of neuroendocrine differentiation.  There is marked nuclear atypia, necrosis, and more than 20 mitoses per 10 HPF.


Low Glutathione Level

An indication that a lower than average level of glutathione was detected in a sample.


Grade 2 Intraoperative Endocrine Injury, CTCAE

Partial resection of injured organ/structure indicated


Nevus of Female Genitalia

A nevus that arises from the female genital organs. This category includes congenital nevus, acquired nevus, dysplastic nevus, blue nevus, and atypical melanocytic nevus of the genital type.


Increased Porphyrin

Increase in the amount of porphyrin.


Metabolic or Respiratory Acidosis, CTCAE


Grade 5 Hypertriglyceridemia, CTCAE

Death


Intraepithelial neoplasia of the penis or vulva. It usually presents as a solitary white or pink macule or plaque that may be slightly elevated. A background of long-standing lichen sclerosus is often present.


Grade 3 Upper Extremity Artery Intra-Operative Injury, CTCAE


Ectromelia

A congenital defect characterized by the absence or hypoplasia of one or more extremities.


Grade 3 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 5 Pancreas Infection, CTCAE

Death


Grade 5 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute Bacterial Prostatitis

An acute infection of the prostate gland caused by bacteria, most often Escherichia coli, Proteus mirabilis, Klebsiella, and Pseudomonas aeruginosa. Signs and symptoms include fever, lower back pain, urinary frequency, and painful urination.  The urinalysis reveals the presence of white cells.  Risk factors include intraprostatic ductal reflux, phimosis, urinary tract infections, and unprotected anal intercourse.


Postoperative Hemorrhage, CTCAE

A disorder characterized by bleeding occurring after a surgical procedure.


Grade 3 Neck Edema, CTCAE

Generalized neck edema (e.g., difficulty in turning neck); limiting self care ADL


Grade 5 Bile Duct Stenosis, CTCAE

Death


Stage IIIC1 Uterine Corpus Cancer AJCC v8

Stage IIIC1 includes: T1-T3, N1/N1mi/N1a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


Breast Nipple and Areolar Deformity, CTCAE


Refractory Malignant Neoplasm of Multiple Primary Sites

Malignant neoplasm of multiple primary sites that is resistant to treatment.


Grade 2 Vagina Stricture or Stenosis, CTCAE


Urethral Melanoma

A rare melanoma that arises from the urethral mucosa.


Grade 3 Vein Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Anus Intra-Operative Injury, CTCAE


Thoracotomy Scar

Replacement of destroyed tissue by fibrous tissue due to a surgical procedure where an incision was made into the chest wall to the left or to the right of the midline.


Pharyngeal Stenosis, CTCAE

A disorder characterized by a narrowing of the pharyngeal airway.


Grade 3 Pulmonary Fibrosis Radiographic Changes, CTCAE


Grade 5 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


P2 Hydronephrosis

Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is greater than or equal to 15 mm, 2) the calyces may be dilated centrally and peripherally, 3) or a dilated ureter is visible, 4) the parenchymal thickness and appearance is normal, and 5) the bladder is normal. Cases in which there is peripheral calyceal dilation but the APRPD is less than 15 mm are classified as UTD P2. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Resectable Malignant Female Reproductive System Neoplasm

A malignant female reproductive system neoplasm that is amenable to surgical resection.


Skin Atrophy, CTCAE 5.0

A disorder characterized by the degeneration and thinning of the epidermis and dermis.


Stage I Gastric Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Cervical Mesonephric Remnants and Hyperplasia

The presence of embryonic remnants of mesonephric ducts in the cervix and their benign hyperplastic proliferations.


Grade 3 Uveitis, CTCAE

Anterior uveitis with 3+ or greater cells; intermediate posterior or pan-uveitis


Glucagonoma, malignant

A glucagon-producing neuroendocrine tumor arising from the alpha cells of the pancreas.  It may be associated with necrolytic erythema migrans, diarrhea, diabetes, glossitis, weight loss, malabsorption, and anemia.  It displays vascular invasion and metastasizes to other anatomic sites.


Benign Osteoclastic Giant Cell-Rich Tumor of Bone

A giant cell tumor that arises from the bone and is characterized by the absence of local aggression and lack of metastatic potential.


Neonatal rickets

Rickets that usually affects premature infants. Factors that contribute to the development of neonatal rickets include calcium, phosphorus, or calciferol deficiency. It manifests with spontaneous fractures, respiratory distress, and growth developmental delays.


Unresectable Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma that is not amenable to surgical resection.


Grade 2 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


Recurrent Plasma Cell Neoplasm

The reemergence of a plasma cell neoplasm after a period of remission.


Prostate Paraganglioma

A paraganglioma that affects the prostate gland.


Anxiety, CTCAE 5.0

A disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.


Adenoma of the Retinal Pigment Epithelium

A benign neoplasm that arises from the retinal pigment epithelium. It consists of cords and tubules of variably pigmented proliferating retinal pigment epithelium cells, separated by fibrous stroma. Malignant transformation is rare. (WHO 2018)


Neonatal Herpes Simplex Infection

Infection in the first month of life caused by the Herpes simplex virus.


Grade 2 Esophageal Infection, CTCAE

Local intervention indicated (e.g., oral antibiotic, antifungal, antiviral)


Grade 3 Other Allergy and Immunology, CTCAE


Grade 2 Movements Involuntary, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 4 Pelvis NOS Intra-Operative Injury, CTCAE


Low Grade Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Grade 1 Nail Ridging, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Neuroendocrine carcinoma of the bladder

A malignant, high grade neuroendocrine neoplasm that arises from the bladder. This category includes small cell and large cell neuroendocrine carcinoma.


Grade 3 Urostomy Obstruction, CTCAE

Altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); elective operative intervention indicated


Grade 1 Urinary Retention, CTCAE

Urinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual


Grade 1 Upper Extremity Vein Intra-Operative Injury, CTCAE


Drug Resistant Epilepsy

Epilepsy that is refractory to treatment.


Grade 1 Bronchopulmonary Dysplasia, AE

An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND breathing room air at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; breathing room air by 56 days postnatal age in infants born greater than 32 weeks' gestation; breathing room air at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


Stage IIIC Esophageal Adenocarcinoma AJCC v7

Stage IIIC includes: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent WHO Grade 3 Glioma

The reemergence of a WHO grade III glioma after a period of remission.


Advanced Adenoid Cystic Carcinoma

Adenoid cystic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 5 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Lacrimal Drainage System Lymphoepithelial Carcinoma

A rare nonkeratinizing squamous cell carcinoma that arises from the lacrimal sac or nasolacrimal duct. It is characterized by the presence of large cells with vesicular nuclei and prominent nucleoli, a syncytial growth pattern, and a lymphoplasmacytic infiltrate.


Thrombosis of abdominal aorta

Formation of blood clot in the lumen of the abdominal aorta. It may lead to severe abdominal pain and ischemic necrosis of the intestine.


Grade 2 Breast Infection, CTCAE

Local infection with moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage IIIA Cervical Cancer FIGO 2018

Cervical carcinoma that involves the lower third of the vagina, with no extension to the pelvic wall. (FIGO 2018)


Facial Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the facial nerve (seventh cranial nerve).


Grade 5 Bronchopulmonary Dysplasia, AE

A bronchopulmonary dysplasia adverse event in a newborn which results in death.


Acquired factor IX deficiency disease

An acquired coagulation disorder characterized by the partial or complete absence of factor IX activity in the blood.


Grade 3 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Life Threatening Adverse Event

An adverse event that has life-threatening consequences; for which urgent intervention is indicated; that puts the patient at risk of death at the time of the event if immediate intervention is not undertaken.


Burn, CTCAE

A finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment.


Refractory Fallopian Tube Adenocarcinoma

Fallopian tube adenocarcinoma that is resistant to treatment.


Grade 3 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Pancreatic Duct Intra-Operative Injury, CTCAE


Grade 4 Carbon Monoxide Diffusion Capacity, CTCAE


Recurrent Childhood Fibrillary Astrocytoma

The reemergence of fibrillary astrocytoma in childhood after a period of remission.


Recurrent Pineal Parenchymal Cell Neoplasm

The reemergence of pineal parenchymal cell neoplasm after a period of remission.


Vagus Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the vagus nerve (tenth cranial nerve).


Grade 3 Social Circumstances - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Gallbladder Pain, CTCAE

Mild pain


Ureteric fistula

An abnormal communication between the ureter and another organ or anatomic site.


Grade 1 Anus Intra-Operative Injury, CTCAE


Grade 4 Stridor, CTCAE

Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Grade 2 Hepatitis B Reactivation, CTCAE

Moderate symptoms; medical intervention indicated


Grade 1 Shingles, CTCAE

Localized, local intervention indicated


Cardiac Enzyme Elevation

An increase from the normal levels of cardiac enzymes measurement.


Grade 2 Meninges Intra-Operative Injury, CTCAE


Broad Ligament Serous Cystadenofibroma

A rare serous cystadenofibroma arising from the broad ligament.


Grade 2 Colonic Obstruction, CTCAE

Symptomatic; altered GI function


Grade 2 Amnesia, CTCAE

Moderate; short term memory loss; limiting instrumental ADL


FNCLCC Sarcoma Grade 3

A sarcoma with a total score of 6 or higher according to the FNCLCC guidelines.


Grade 3 Arterial Injury, CTCAE

Severe symptoms; limiting self care ADL; repair or revision indicated


Grade 3 Esophageal Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated; limiting self care ADL


Male Reproductive System Precancerous Condition

A premalignant pathologic process arising from an organ of the male reproductive system.  It is characterized by cellular atypia and/or dysplasia but does not show morphologic evidence of stromal invasion at the time of diagnosis.  Representative examples include prostatic intraepithelial neoplasia, giant condyloma acuminatum of the penis, and penile intraepithelial neoplasia.


Grade 1 Dermatitis Radiation, CTCAE

Faint erythema or dry desquamation


Grade 1 Jejunal Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Metastatic Bone Sarcoma

Bone sarcoma that has spread from the original site of growth to another anatomic site.


Hepatic Failure, CTCAE

A disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, alkaline phosphatase, aminotransferase, and/or prolongation of prothrombin time (INR.) Drug-induced liever injury (DILI) as defined by Hy's Law.


BAP1-Inactivated Skin Melanocytic Neoplasm

A group of cutaneous melanocytic neoplasms that includes the combined BAP1-inactivated nevus and the BAP1-inactivated melanocytoma.


Hyperplasia of Brunner glands of duodenum

A rare hyperplastic lesion of Brunner's gland in the duodenum. Although it is usually asymptomatic and discovered incidentally during upper gastrointestinal endoscopy, it may cause hemorrhage.


Grade 1 Testis Intra-Operative Injury, CTCAE


Grade 2 Pleural Effusion, CTCAE

Symptomatic; intervention indicated (e.g., diuretics or therapeutic thoracentesis)


Stage IVA Oral Cavity Verrucous Carcinoma


B-Cell Proliferation of Uncertain Malignant Potential

A B-cell lymphoproliferative disorder with uncertain malignant potential. The representative example of this category is lymphomatoid granulomatosis.


Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Vulvar Carcinoma

Vulvar carcinoma that does not respond to treatment.


Grade 3 Cataract, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Premature Delivery, CTCAE

A disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation.


Grade 3 Sleep Apnea, CTCAE

Oxygen desaturation; associated with pulmonary hypertension; medical intervention indicated; limiting self care ADL


Grade 1 Bronchopulmonary Hemorrhage NOS, CTCAE


Grade 5 Lymph Leakage, CTCAE

Death


Grade 2 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 3 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Appendicitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Foreign-Body Reaction

An inflammatory lesion comprised of epithelioid histiocytes and chronic inflammation that is caused by the presence of extraneous material.


Non-Neoplastic Musculoskeletal Disorder

A non-neoplastic disorder that affects muscles and bones.


Grade 3 Pharynx Obstruction and Stenosis, CTCAE


Grade 2 Blood Bilirubin Increased, CTCAE

>1.5-3.0 x ULN if baseline was normal; >1.5-3.0 x baseline if baseline was abnormal


lymphomatoid papulosis, type C

A variant of lymphomatoid papulosis characterized clinically by regressing skin papules, and morphologically by features resembling anaplastic large cell lymphoma.


Ovarian or testicular dysfunction associated with high levels of gonadotropins, that is present at birth.


Recurrent Ampulla of Vater Adenocarcinoma

The reemergence of ampulla of Vater adenocarcinoma after a period of remission.


Maternal Weight Gain in Pregnancy

The last recorded maternal weight prior to birth minus the last recorded weight immediately prior to pregnancy. (reVITALize)


Congenital Cystic Hygroma

A congenital lymphatic malformation usually arising from the neck and characterized by cystic dilation of the lymphatic vessels.


Adenocarcinoma endometrial metastatic

An adenocarcinoma which originated in the endometrium and has spread to another anatomic site.


Refractory Acute Myeloid Leukemia Not Otherwise Specified

Acute myeloid leukemia not otherwise specified that does not respond to treatment.


Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder

The reemergence of monomorphic post-transplant lymphoproliferative disorder after a period of remission.


Grade 5 Splenic Infection, CTCAE

Death


An exceedingly rare adenocarcinoma that arises from the endometrium and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Grade 1 Flatulence, CTCAE

Mild symptoms; intervention not indicated


Stage IB Gastric Carcinoma

Stage IB includes: (T2, N0, M0); (T1, N1, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Appendicitis Perforated, CTCAE

A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.


Grade 3 Prolapse of Intestinal Stoma, CTCAE

Severe symptoms; elective operative intervention indicated; limiting self care ADL


Female urinary-genital tract fistula

An abnormal connection between the urinary system and the genitals in a female.


Grade 3 Lymph Node Pain, CTCAE

Severe pain; limiting self care ADL


Primary Malignant Pelvic Neoplasm

A malignant neoplasm that arises from the organs and structures of the pelvis.


Grade 2 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Severe Cardiac Valve Regurgitation

Evidence of severe retrograde blood flow through the valve(s) of the heart. (ACC)


FIGO Grade 1 Endometrial Mucinous Adenocarcinoma

A primary mucinous adenocarcinoma of the endometrium that contains equal to or less than 5% non-squamous solid areas.


Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Gallbladder Intra-Operative Injury, CTCAE


Mixed Cellularity Classic Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for mixed cellularity classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Grade 4 Gallbladder Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Breast Atrophy, CTCAE

Minimal asymmetry; minimal atrophy


Grade 3 Bladder Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Stage III Urethral Cancer AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0). T1: For male penile urethra and female urethra: Tumor invades subepithelial connective tissue. For prostatic urethra: Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. T3: For male penile urethra and female urethra: Tumor invades any of the following: corpus cavernosum, anterior vagina. For prostatic urethra: Tumor invades the periprostatic fat. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IIIA Appendix Carcinoma AJCC v8

Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


clear cell adenocarcinoma of gallbladder

A rare morphologic variant of gallbladder adenocarcinoma composed of malignant glandular epithelium with a predominance of glycogen rich clear cells.  The cells display hyperchromic nuclei and well-defined cytoplasmic borders.


Nervous System Disorders - Other, Specify, CTCAE


Chronic inflammation

An inflammatory process characterized by the presence of lymphocytes and plasma cells and the absence of polymorphonuclear neutrophils.


Fetal Neurodevelopmental Disorder

A fetal affliction that has a neurological basis and manifests as a developmental disability.


Grade 3 Colonic Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Recurrent Anaplastic Astrocytoma

The reemergence of anaplastic astrocytoma after a period of remission.


Grade 4 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


Grade 5 Neonatal Respiratory Insufficiency, AE

A respiratory insufficiency adverse event in a newborn which results in death.


Miserable Pain

A sensation of discomfort or distress that renders an individual unable to find any happiness.


Grade 3 Bullous Dermatitis, CTCAE

Blisters covering >30% BSA; limiting self care ADL


Stage I Vulvar Cancer

Stage I includes: T1, N0, M0. T1: Invasive vulvar cancer confined to the vulva or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 5 Vagus Nerve Disorder, CTCAE

Death


T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta

An uncommon variant of T-cell large granular lymphocyte leukemia expressing the gamma-delta T-cell receptor. Approximately 60% of these cases are CD8-positive and the remainder are CD4/CD8-negative.


Unresectable Low Grade Glioma

Low grade glioma that is not amenable to surgical removal.


trauma to the abdomen

Trauma to the abdomen.


Gastrointestinal Perforation, CTCAE

An adverse event marked by rupture in the wall of a structure of the gastrointestinal system.


Stage III Bone Cancer AJCC v8

Stage III includes: T3, N0, M0, G2 or G3. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Grade 2 Colon Intra-Operative Injury, CTCAE


Radiating Chest Pain Along Right Middle Sternal Border

The location of the radiating chest pain is along the right middle sternal border.


Pancreatic Enzymes Decreased

A laboratory test result which indicates decreased levels of pancreatic enzymes in a biologic specimen.


Grade 1 Upper Extremity Intra-Operative Injury, CTCAE


Stage I Bone Cancer AJCC v7

Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 1 Leukoencephalopathy Radiographic Findings, CTCAE


Metastatic malignant neoplasm to retina

A malignant neoplasm that has spread to the retina from another anatomic site.


Stage IVB Uterine Corpus Cancer AJCC v7

Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone.  It excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa). This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Stage IB3 Cervical Cancer FIGO 2018

Invasive cervical carcinoma equal or more than 4 cm in greatest dimension. (FIGO 2018)


Cutaneous Mature B-Cell Neoplasm

A B-cell neoplasm that arises from the skin.


Grade 3 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Prostate Melanoma

An exceptionally rare melanoma arising from the prostate gland.


Grade 3 Retinal Vascular Disorder, CTCAE

Retinal vascular disorder with neovascularization


Deep Lipoma

A benign well-circumscribed tumor, composed of mature adipocytes, that arises within deep soft tissues.


Craniofacial Fibrous Dysplasia

Fibrous dysplasia affecting the craniofacial bones.


Grade 5 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Muscular and Skeletal Hypoplasia, CTCAE


Grade 2 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cardiac granuloma

A granuloma located in the myocardium.


Grade 3 Pancreatic Duct Intra-Operative Injury, CTCAE


Grade 2 Proctitis, CTCAE

Symptomatic (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental ADL


Persistent Pulmonary Hypertension of the Newborn, AE

An adverse event in a newborn characterized by elevated pulmonary vascular pressure in a neonate.


Grade 5 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Elevated DKK1

A finding indicating elevated concentrations of DKK1 in a sample.


Grade 5 Cecal Infection, CTCAE

Death


Neonatal Spell

Cardiorespiratory events that are characterized by variable combinations of cessation of breathing, decrease in blood oxygen saturation, and decreased heart rate.


Stage IIA Esophagus Carcinoma

Stage IIA includes: For squamous cell carcinoma: (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X).  For adenocarcinoma: (T2, N0, M0, G3).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Grade 4 Ovary Intra-Operative Injury, CTCAE


Mucositis and Stomatitis by Functional and Symptomatic Classification, CTCAE


Leukopenia neonatal

Leukopenia that occurs in the neonatal period.


Acute lymphoblastic leukemia recurrent

The reemergence of acute lymphoblastic leukemia after a period of remission.


Pancreatic intraepithelial neoplasia

A pre-cancerous, non-invasive pancreatic epithelial neoplasm that arises from and is confined to the pancreatic ducts.  It is a papillary or flat neoplasm that usually measures less than 5 mm in diameter.


Esophageal Cancer by AJCC v8 Stage

A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 8th edition.


Stage IIIB Merkel Cell Carcinoma AJCC v7

Stage IIIB includes: Any T, N1b/N2, M0.  N1b: Macrometastasis in regional lymph nodes.  N2: In transit metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Recurrent Myeloproliferative Neoplasm

The reemergence of a myeloproliferative neoplasm after a period of remission.


Burn of axilla

A traumatic injury to the axilla resulting from exposure to caustic chemicals, extreme heat, extreme cold, or excessive radiation.


Grade 3 Hematosalpinx, CTCAE

Transfusion indicated; invasive intervention indicated


Bladder Infection, CTCAE

A disorder characterized by an infectious process involving the bladder.


Adverse Event Attributed to Disease

An indication that an adverse event is causally related to the natural history of disease.


Grade 2 Mucositis Oral, CTCAE

Moderate pain or ulcer that does not interfere with oral intake; modified diet indicated


Grade 5 Arteritis Infective, CTCAE

Death


Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Pancreatic Endocrine Glucose Intolerance, CTCAE