Octopamine

An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.

A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.


Oleandrin

A steroid saponin that consists of oleandrigenin having a 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl residue attached to the oxygen function at position 3.


NOTC1_MOUSE Neurogenic locus notch homolog protein 1 (sprot)

A neurogenic locus notch homolog protein 1 that is encoded in the genome of mouse.


Oleic Acid

An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)

An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.


FABP5_HUMAN Fatty acid-binding protein 5 (sprot)

A fatty acid-binding protein 5 that is encoded in the genome of human.


FABPL_HUMAN Fatty acid-binding protein, liver (sprot)

A fatty acid-binding protein, liver that is encoded in the genome of human.


Oxethazaine

isolated from bioactive leaf extracts of Rollinia mucosa


Adipic Acid

An alpha,omega-dicarboxylic acid that is the 1,4-dicarboxy derivative of butane.


TBA1B_HUMAN Tubulin alpha-1B chain (sprot)

A tubulin alpha-1B chain that is encoded in the genome of human.


TBA4A_HUMAN Tubulin alpha-4A chain (sprot)

A tubulin alpha-4A chain that is encoded in the genome of human.


TBA3E_HUMAN Tubulin alpha-3E chain (sprot)

A tubulin alpha-3E chain that is encoded in the genome of human.


TBA1A_HUMAN Tubulin alpha-1A chain (sprot)

A tubulin alpha-1A chain that is encoded in the genome of human.


TBA1C_HUMAN Tubulin alpha-1C chain (sprot)

A tubulin alpha-1C chain that is encoded in the genome of human.


VE2_HPV16 Regulatory protein E2 (sprot)

A protein that is a translation product of the E2 gene in Human papillomavirus type 16.


Estradiol phosphate

polymeric phosphoric acid ester of estradiol


Practolol

A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.

N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias.


ADRB2_MOUSE Beta-2 adrenergic receptor (sprot)

A beta-2 adrenergic receptor that is encoded in the genome of mouse.


Propamidine

A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.


Propoxycaine

A local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1017)


PROTOPORPHYRIN

A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.


3-Pyridineacetic acid

A monocarboxylic acid that is acetic acid substituted by a (pyridin-3-yl) group. It is a metabolite of nicotine and other tobacco alkaloids.


Pyridoxal phosphate

This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).

The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.


PPAC_HUMAN Low molecular weight phosphotyrosine protein phosphatase (sprot)

A low molecular weight phosphotyrosine protein phosphatase that is encoded in the genome of human.


CDK1_HUMAN Cyclin-dependent kinase 1 (sprot)

A cyclin-dependent kinase 1 that is encoded in the genome of human.


PLK1_HUMAN Serine/threonine-protein kinase PLK1 (sprot)

A serine/threonine-protein kinase PLK1 that is encoded in the genome of human.


PPCE_HUMAN Prolyl endopeptidase (sprot)

A prolyl endopeptidase that is encoded in the genome of human.


PYGL_HUMAN Glycogen phosphorylase, liver form (sprot)

A glycogen phosphorylase, liver form that is encoded in the genome of human.


Q965D5_PLAFA Enoyl-acyl-carrier protein reductase (trembl)


5NTD_RAT 5'-nucleotidase (sprot)

A 5'-nucleotidase that is encoded in the genome of rat.


Q965D6_PLAFA 3-oxoacyl-acyl-carrier protein reductase (trembl)


Q965D7_PLAFA 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (trembl)


P85A_HUMAN Phosphatidylinositol 3-kinase regulatory subunit alpha (sprot)

A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human.


NOX4_HUMAN NADPH oxidase 4 (sprot)

An NADPH oxidase 4 that is encoded in the genome of human.


DDL_HELPH D-alanine--D-alanine ligase (sprot)


NEK6_HUMAN Serine/threonine-protein kinase Nek6 (sprot)

A serine/threonine-protein kinase Nek6 that is encoded in the genome of human.


CCNB1_HUMAN G2/mitotic-specific cyclin-B1 (sprot)

A G2/mitotic-specific cyclin-B1 that is encoded in the genome of human.


CD5R1_HUMAN Cyclin-dependent kinase 5 activator 1 (sprot)

A cyclin-dependent kinase 5 activator 1 that is encoded in the genome of human.


CCNB2_HUMAN G2/mitotic-specific cyclin-B2 (sprot)

A G2/mitotic-specific cyclin-B2 that is encoded in the genome of human.


CCNB3_HUMAN G2/mitotic-specific cyclin-B3 (sprot)

A G2/mitotic-specific cyclin-B3 that is encoded in the genome of human.


CCND1_HUMAN G1/S-specific cyclin-D1 (sprot)

A G1/S-specific cyclin-D1 that is encoded in the genome of human.


GSK3A_HUMAN Glycogen synthase kinase-3 alpha (sprot)

A glycogen synthase kinase-3 alpha that is encoded in the genome of human.


CTRC_HUMAN Chymotrypsin-C (sprot)

A chymotrypsin-C that is encoded in the genome of human.


CDK5_RAT Cyclin-dependent kinase 5 (sprot)

A cyclin-dependent kinase 5 that is encoded in the genome of rat.


HIF1N_HUMAN Hypoxia-inducible factor 1-alpha inhibitor (sprot)

A hypoxia-inducible factor 1-alpha inhibitor that is encoded in the genome of human.


DDLB_ECOLI D-alanine--D-alanine ligase B (sprot)

A D-alanine--D-alanine ligase B that is encoded in the genome of Escherichia coli K-12.


CD38_HUMAN ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (sprot)

An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 that is encoded in the genome of human.


PDE2A_RAT cGMP-dependent 3',5'-cyclic phosphodiesterase (sprot)

A cGMP-dependent 3',5'-cyclic phosphodiesterase that is encoded in the genome of rat.


GSHR_YEAST Glutathione reductase (sprot)

A glutathione reductase, mitochondrial that is encoded in the genome of yeast.


GTR2_HUMAN Solute carrier family 2, facilitated glucose transporter member 2 (sprot)

A solute carrier family 2, facilitated glucose transporter member 2 that is encoded in the genome of human.


ELAV3_HUMAN ELAV-like protein 3 (sprot)

An ELAV-like protein 3 that is encoded in the genome of human.


ELAV1_HUMAN ELAV-like protein 1 (sprot)

An ELAV-like protein 1 that is encoded in the genome of human.


GLUT4_RAT Solute carrier family 2, facilitated glucose transporter member 4 (sprot)

A solute carrier family 2, facilitated glucose transporter member 4 that is encoded in the genome of rat.


IPMK_HUMAN Inositol polyphosphate multikinase (sprot)

An inositol polyphosphate multikinase that is encoded in the genome of human.


IP6K2_HUMAN Inositol hexakisphosphate kinase 2 (sprot)

An inositol hexakisphosphate kinase 2 that is encoded in the genome of human.


Rioprostil

A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against NSAID-induced gastric mucosal damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.


AKT3_HUMAN RAC-gamma serine/threonine-protein kinase (sprot)

A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of human.


KGP2_HUMAN cGMP-dependent protein kinase 2 (sprot)

A cGMP-dependent protein kinase 2 that is encoded in the genome of human.


CDKL5_HUMAN Cyclin-dependent kinase-like 5 (sprot)

A cyclin-dependent kinase-like 5 that is encoded in the genome of human.


PI51C_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (sprot)

A phosphatidylinositol 4-phosphate 5-kinase type-1 gamma that is encoded in the genome of human.


KPCD_RAT Protein kinase C delta type (sprot)

A protein that is a translation product of the Prkcd gene in rat.


KPCE_RAT Protein kinase C epsilon type (sprot)

A protein kinase C epsilon that is encoded in the genome of rat.


KPCZ_RAT Protein kinase C zeta type (sprot)

A protein kinase C zeta type that is encoded in the genome of rat.


KPCL_RAT Protein kinase C eta type (sprot)

A protein kinase C eta type that is encoded in the genome of rat.


KPCA_RAT Protein kinase C alpha type (sprot)

A protein kinase C alpha type that is encoded in the genome of rat.


KPCG_RAT Protein kinase C gamma type (sprot)

A protein kinase C gamma type that is encoded in the genome of rat.


KPCB_RAT Protein kinase C beta type (sprot)

A protein kinase C beta type that is encoded in the genome of rat.


KPCT_RAT Protein kinase C theta type (sprot)

A protein kinase C theta type that is encoded in the genome of rat.


NMUR2_HUMAN Neuromedin-U receptor 2 (sprot)

A neuromedin-U receptor 2 that is encoded in the genome of human.


Sabcomeline

selective for M1 receptors; RN refers to (R,S)-isomer


Saralasin

An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.


RASH_HUMAN GTPase HRas (sprot)

A GTPase HRas that is encoded in the genome of human.


Sulmazole

An imidazopyridine that is 1H-imidazo[4,5-b]pyridine which is substituted at position 2 by a 2-methoxy-4-(methylsulfinyl)phenyl group. An A1 adenosine receptor antagonist, it was formerly used as a cardiotonic agent.


Thiram

A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.

An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.


BODG_HUMAN Gamma-butyrobetaine dioxygenase (sprot)

A gamma-butyrobetaine dioxygenase that is encoded in the genome of human.


Tioxolone

A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.


PEPA5_HUMAN Pepsin A-5 (sprot)

A pepsin A-5 that is encoded in the genome of human.


TTPA_HUMAN Alpha-tocopherol transfer protein (sprot)

An alpha-tocopherol transfer protein that is encoded in the genome of human.


Toliprolol

was MH 1975-92 (see under PROPANOLAMINES 1981-90, was DOBEROL see under PROPANOLAMINES 1975-80); KOE 592 was see TOLIPROLOL 1975-92; use PROPANOLAMINES to search TOLIPROLOL 1975-92; beta adrenergic blockader with some stimulant action; it has been proposed for angina pectoris


Triclocarban

bacteriostat; antiseptic in soaps & other cleansing solns; germicide; structure

A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.


HYEP_HUMAN Epoxide hydrolase 1 (sprot)

An epoxide hydrolase 1 that is encoded in the genome of human.


HYEP_MOUSE Epoxide hydrolase 1 (sprot)

An epoxide hydrolase 1 that is encoded in the genome of mouse.


CBR1_HUMAN Carbonyl reductase [NADPH] 1 (sprot)

A carbonyl reductase [NADPH] 1 that is encoded in the genome of human.


FABI_STAAR Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (sprot)


FABI_BACSU Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (sprot)


Q6UCJ9_TOXGO Enoyl-acyl carrier reductase (trembl)


Q9BJJ9_PLAFA Enoyl-ACP reductase (Fragment) (trembl)


Q9RMI3_STAAU Enoyl-[acyl-carrier-protein] reductase [NADPH] (trembl)


M9TGV3_MYCTX Enoyl-[acyl-carrier-protein] reductase [NADH] (trembl)


Uridine 5'-triphosphate

Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.

A pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase.


SEPR_MOUSE Prolyl endopeptidase FAP (sprot)

A prolyl endopeptidase FAP that is encoded in the genome of mouse.


E1BI31_BOVIN Dipeptidyl peptidase 9 (trembl)


Xanomeline

a cholinergic agonist; used in the treatment of Alzheimer's disease; structure given in first source


Azacyclonol

major descriptor (65-84); on-line search PIPERIDINES (65-84); Index Medicus search AZACYCLONOL (65-84); RN given refers to parent cpd


Ciramadol

benzylamine analgesics; structure given in fourth source


Behenic Acid

A straight-chain, C22, long-chain saturated fatty acid.


NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (sprot)

A nuclear receptor subfamily 4 group A member 1 that is encoded in the genome of human.


Clorotepine

major tranquilizer with action similar to those of the phenothiazines; used in schizophrenic & manic psychoses; minor decriptor (77-86); on-line & INDEX MEDICUS search DIBENZOTHIEPINS (77-86); RN given refers to parent cpd without isomeric designation


GLUCB_HAECO Glutamate-gated chloride channel subunit beta (sprot)


Q25634_ONCVO Glutamate-gated chloride channel (Fragment) (trembl)


AT2A2_RAT Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (sprot)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 that is encoded in the genome of rat.


AT1A1_RAT Sodium/potassium-transporting ATPase subunit alpha-1 (sprot)

A sodium/potassium-transporting ATPase subunit alpha-1 that is encoded in the genome of rat.


AT2A1_RAT Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (sprot)

A protein that is a translation product of the Atp2a1 gene in rat.


Kinetin

A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.

A member of the class of 6-aminopurines that is  adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.


Kojic acid

A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae.


OXDA_PIG D-amino-acid oxidase (sprot)

A D-amino-acid oxidase that is encoded in the genome of pig.


TYRO_MOUSE Tyrosinase (sprot)

A tyrosinase that is encoded in the genome of mouse.


Tirilazad

a lazaroid; potent inhibitor of iron-dependent lipid peroxidation; has shown excellent activity in in vivo models of experimental central nervous system trauma & ischemia; structure given in first source; tradename Freedox


Meldonium

structural analog of gamma-butyrobetaine, also of carnitine; antianginal compound; MET-88 is dihydrate; structure given in first source

An ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, atherosclerosis and diabetes.


Octanoic acid

A straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid.


GPR84_HUMAN G-protein coupled receptor 84 (sprot)

A G-protein coupled receptor 84 that is encoded in the genome of human.


Baicalin

has iron chelating activity; chemical component of Chinese medicinal herb Huang-chin (Scutellaria baicalensis); do not confuse with baicalein

The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis.


P4HA1_HUMAN Prolyl 4-hydroxylase subunit alpha-1 (sprot)

A prolyl 4-hydroxylase subunit alpha-1 that is encoded in the genome of human.


PLOD1_HUMAN Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (sprot)

A procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 that is encoded in the genome of human.


S23A2_HUMAN Solute carrier family 23 member 2 (sprot)

A solute carrier family 23 member 2 that is encoded in the genome of human.


S23A1_HUMAN Solute carrier family 23 member 1 (sprot)

A solute carrier family 23 member 1 that is encoded in the genome of human.


AMYP_RAT Pancreatic alpha-amylase (sprot)

A protein that is a translation product of the Amy2 gene in rat.


Levamlodipine

The (4S)-enantiomer of amlodipine.


GPR18_HUMAN N-arachidonyl glycine receptor (sprot)

An N-arachidonyl glycine receptor that is encoded in the genome of human.


CNR1_MOUSE Cannabinoid receptor 1 (sprot)

A cannabinoid receptor 1 that is encoded in the genome of mouse.


CNR2_RAT Cannabinoid receptor 2 (sprot)

A cannabinoid receptor 2 that is encoded in the genome of rat.


CD11B_HUMAN Cyclin-dependent kinase 11B (sprot)

A cyclin-dependent kinase 11B that is encoded in the genome of human.


CD11A_HUMAN Cyclin-dependent kinase 11A (sprot)

A cyclin-dependent kinase 11A that is encoded in the genome of human.


M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 (sprot)

A mitogen-activated protein kinase kinase kinase 10 that is encoded in the genome of human.


NEK5_HUMAN Serine/threonine-protein kinase Nek5 (sprot)

A serine/threonine-protein kinase Nek5 that is encoded in the genome of human.


ADCK1_HUMAN AarF domain-containing protein kinase 1 (sprot)

An AarF domain-containing protein kinase 1 that is encoded in the genome of human.


HDAC5_HUMAN Histone deacetylase 5 (sprot)

A histone deacetylase 5 that is encoded in the genome of human.


HDAC7_HUMAN Histone deacetylase 7 (sprot)

A histone deacetylase 7 that is encoded in the genome of human.


HDAC4_HUMAN Histone deacetylase 4 (sprot)

A histone deacetylase 4 that is encoded in the genome of human.


HDAC9_HUMAN Histone deacetylase 9 (sprot)

A histone deacetylase 9 that is encoded in the genome of human.


NCOR2_HUMAN Nuclear receptor corepressor 2 (sprot)

A nuclear receptor corepressor 2 that is encoded in the genome of human.


NCOR1_HUMAN Nuclear receptor corepressor 1 (sprot)

A nuclear receptor corepressor 1 that is encoded in the genome of human.


HDAC6_MOUSE Histone deacetylase 6 (sprot)

A histone deacetylase 6 that is encoded in the genome of mouse.


HDA11_HUMAN Histone deacetylase 11 (sprot)

A histone deacetylase 11 that is encoded in the genome of human.


Phosphoserine

The L-enantiomer of O-phosphoserine.


CLCN2_HUMAN Chloride channel protein 2 (sprot)

A chloride channel protein 2 that is encoded in the genome of human.


Q94F81_MAIZE HD2 type histone deacetylase HDA106 (trembl)


HDAC1_MOUSE Histone deacetylase 1 (sprot)

A histone deacetylase 1 that is encoded in the genome of mouse.


Q9ZTP8_MAIZE Histone deacetylase (trembl)


Q9XYC7_PLAFA Histone deacetylase (trembl)


HDAH_ALCSD Histone deacetylase-like amidohydrolase (sprot)


Q7K6A1_PLAF7 Histone deacetylase (trembl)


B1WBY8_RAT histone deacetylase (Fragment) (trembl)


HDAC1_RAT Histone deacetylase 1 (sprot)

A histone deacetylase 1 that is encoded in the genome of rat.


Q5RJZ2_RAT Hdac5 protein (Fragment) (trembl)


HDAC3_RAT Histone deacetylase 3 (sprot)

A histone deacetylase 3 that is encoded in the genome of rat.


HDAC7_RAT Histone deacetylase 7 (Fragment) (sprot)


Q99P97_RAT Histone deacetylase 6 (Fragment) (trembl)


HDAC4_RAT Histone deacetylase 4 (sprot)

A histone deacetylase 4 that is encoded in the genome of rat.


A5H660_SCHMA Histone deacetylase 8 (trembl)


LKHA4_MOUSE Leukotriene A-4 hydrolase (sprot)

A leukotriene A-4 hydrolase that is encoded in the genome of mouse.


Asparagine

A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

An optically active form of asparagine having L-configuration.


GGT1_RAT Glutathione hydrolase 1 proenzyme (sprot)

A protein that is a translation product of the Ggt1 gene in rat.


AAA1_RAT Asc-type amino acid transporter 1 (sprot)

An asc-type amino acid transporter 1 that is encoded in the genome of rat.


Valine

A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.

The L-enantiomer of valine.


Sodium dodecyl sulfate

An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.


Q2VKV7_SARSC Sodium channel protein (Fragment) (trembl)


SGPL1_HUMAN Sphingosine-1-phosphate lyase 1 (sprot)

A sphingosine-1-phosphate lyase 1 that is encoded in the genome of human.


S1PR1_HUMAN Sphingosine 1-phosphate receptor 1 (sprot)

A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human.


S1PR5_HUMAN Sphingosine 1-phosphate receptor 5 (sprot)

A sphingosine 1-phosphate receptor 5 that is encoded in the genome of human.


S1PR4_HUMAN Sphingosine 1-phosphate receptor 4 (sprot)

A sphingosine 1-phosphate receptor 4 that is encoded in the genome of human.


S1PR3_HUMAN Sphingosine 1-phosphate receptor 3 (sprot)

A sphingosine 1-phosphate receptor 3 that is encoded in the genome of human.


TRPM7_MOUSE Transient receptor potential cation channel subfamily M member 7 (sprot)

A transient receptor potential cation channel subfamily M member 7 that is encoded in the genome of mouse.


SGPL1_MOUSE Sphingosine-1-phosphate lyase 1 (sprot)

A sphingosine-1-phosphate lyase 1 that is encoded in the genome of mouse.


CATL2_HUMAN Cathepsin L2 (sprot)

A cathepsin L2 that is encoded in the genome of human.


CATK_HUMAN Cathepsin K (sprot)

A cathepsin K that is encoded in the genome of human.


CATS_HUMAN Cathepsin S (sprot)

A cathepsin S that is encoded in the genome of human.


CATF_HUMAN Cathepsin F (sprot)

A cathepsin F that is encoded in the genome of human.


D2K2A8_9HEPC Non-structural protein 4A (Fragment) (trembl)


A0A0K1CY61_9HEPC Genome polyprotein (Fragment) (trembl)


R1A_SARS Replicase polyprotein 1a (sprot)


CELA1_HUMAN Chymotrypsin-like elastase family member 1 (sprot)

A chymotrypsin-like elastase family member 1 that is encoded in the genome of human.


C1KIQ2_9HEPC Genome polyprotein (Fragment) (trembl)


Q0ZMF1_9HEPC Genome polyprotein (Fragment) (trembl)


Q91RS4_9HEPC Genome polyprotein (Fragment) (trembl)


RON_HUMAN Macrophage-stimulating protein receptor (sprot)

A macrophage-stimulating protein receptor that is encoded in the genome of human.


ST32A_HUMAN Serine/threonine-protein kinase 32A (sprot)

A serine/threonine-protein kinase 32A that is encoded in the genome of human.


RPOZ_CLOD6 DNA-directed RNA polymerase subunit omega (sprot)

A protein that is a translation product of the rpoZ gene in Peptoclostridium difficile 630.


RPOB_CLOD6 DNA-directed RNA polymerase subunit beta (sprot)

A DNA-directed RNA polymerase subunit beta that is encoded in the genome of Peptoclostridium difficile 630.


RPOC_CLOD6 DNA-directed RNA polymerase subunit beta' (sprot)

A DNA-directed RNA polymerase subunit beta' that is encoded in the genome of Peptoclostridium difficile 630.


RPOA_CLOD6 DNA-directed RNA polymerase subunit alpha (sprot)

A DNA-directed RNA polymerase subunit alpha that is encoded in the genome of Peptoclostridium difficile 630.


Retigabine

It is a first-in-class anticonvulsant that works by activating KCNQ2/3 channels. In vitro studies indicate that ezogabine enhances transmembrane potassium currents mediated by the KCNQ (Kv7.2 to 7.5) family of ion channels. By activating KCNQ channels, ezogabine is thought to stabilize the resting membrane potential and reduce brain excitability.

A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An  anticonvulsant used to treat seizures associated with epilepsy in adults.


KCNQ2_MOUSE Potassium voltage-gated channel subfamily KQT member 2 (sprot)

A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of mouse.


FA10_RABIT Coagulation factor X (sprot)

A coagulation factor X that is encoded in the genome of rabbit.


P2Y12_RAT P2Y purinoceptor 12 (sprot)

A P2Y purinoceptor 12 that is encoded in the genome of rat.


RASK_HUMAN GTPase KRas (sprot)

A GTPase KRas that is encoded in the genome of human.


BKRB2_RAT B2 bradykinin receptor (sprot)

A B2 bradykinin receptor that is encoded in the genome of rat.


BKRB2_CAVPO B2 bradykinin receptor (sprot)

A B2 bradykinin receptor that is encoded in the genome of guinea pig.


BKRB1_HUMAN B1 bradykinin receptor (sprot)

A B1 bradykinin receptor that is encoded in the genome of human.


BKRB2_MOUSE B2 bradykinin receptor (sprot)

A B2 bradykinin receptor that is encoded in the genome of mouse.


BKRB1_RAT B1 bradykinin receptor (sprot)

A B1 bradykinin receptor that is encoded in the genome of rat.


ZAP70_HUMAN Tyrosine-protein kinase ZAP-70 (sprot)

A tyrosine-protein kinase ZAP-70 that is encoded in the genome of human.


NEK9_HUMAN Serine/threonine-protein kinase Nek9 (sprot)

A serine/threonine-protein kinase Nek9 that is encoded in the genome of human.


RON_MOUSE Macrophage-stimulating protein receptor (sprot)

A macrophage-stimulating protein receptor that is encoded in the genome of mouse.


TIE2_MOUSE Angiopoietin-1 receptor (sprot)

An angiopoietin-1 receptor that is encoded in the genome of mouse.


CSKP_HUMAN Peripheral plasma membrane protein CASK (sprot)

A peripheral plasma membrane protein CASK that is encoded in the genome of human.


NPM_HUMAN Nucleophosmin (sprot)

A nucleophosmin that is encoded in the genome of human.


SHIP2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (sprot)

A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 that is encoded in the genome of human.


MLKL_HUMAN Mixed lineage kinase domain-like protein (sprot)

A mixed lineage kinase domain-like protein that is encoded in the genome of human.


ALK_MOUSE ALK tyrosine kinase receptor (sprot)

An ALK tyrosine kinase receptor that is encoded in the genome of mouse.


PLK3_HUMAN Serine/threonine-protein kinase PLK3 (sprot)

A serine/threonine-protein kinase PLK3 that is encoded in the genome of human.


NEK3_HUMAN Serine/threonine-protein kinase Nek3 (sprot)

A serine/threonine-protein kinase Nek3 that is encoded in the genome of human.


JAK2_MOUSE Tyrosine-protein kinase JAK2 (sprot)

A tyrosine-protein kinase JAK2 that is encoded in the genome of mouse.


STRAA_HUMAN STE20-related kinase adapter protein alpha (sprot)

A STE20-related kinase adapter protein alpha that is encoded in the genome of human.


MAPK5_HUMAN MAP kinase-activated protein kinase 5 (sprot)

A MAP kinase-activated protein kinase 5 that is encoded in the genome of human.


METH_HUMAN Methionine synthase (sprot)

A methionine synthase that is encoded in the genome of human.


MTRR_HUMAN Methionine synthase reductase (sprot)

A methionine synthase reductase that is encoded in the genome of human.


AMNLS_HUMAN Protein amnionless (sprot)

A protein amnionless that is encoded in the genome of human.


MMAB_HUMAN Corrinoid adenosyltransferase MMAB (sprot)

A corrinoid adenosyltransferase MMAB that is encoded in the genome of human.


MMAA_HUMAN Methylmalonic aciduria type A protein, mitochondrial (sprot)

A methylmalonic aciduria type A, mitochondrial that is encoded in the genome of human.


TCO2_HUMAN Transcobalamin-2 (sprot)

A transcobalamin-2 that is encoded in the genome of human.


TCO1_HUMAN Transcobalamin-1 (sprot)

A transcobalamin-1 that is encoded in the genome of human.


IMPA1_HUMAN Inositol monophosphatase 1 (sprot)

An inositol monophosphatase 1 that is encoded in the genome of human.


FFAR2_HUMAN Free fatty acid receptor 2 (sprot)

A free fatty acid receptor 2 that is encoded in the genome of human.


FFAR3_HUMAN Free fatty acid receptor 3 (sprot)

A free fatty acid receptor 3 that is encoded in the genome of human.


SHH_MOUSE Sonic hedgehog protein (sprot)

A sonic hedgehog protein that is encoded in the genome of mouse.


SHH_HUMAN Sonic hedgehog protein (sprot)

A sonic hedgehog protein that is encoded in the genome of human.


SMO_HUMAN Protein smoothened (sprot)

A smoothened that is encoded in the genome of human.


SMO_MOUSE Protein smoothened (sprot)

A smoothened that is encoded in the genome of mouse.


EPOR_HUMAN Erythropoietin receptor (sprot)

An erythropoietin receptor that is encoded in the genome of human.


Thymol

A phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent.

A phenol that is a natural monoterpene derivative of cymene.


Q4QYD9_RAT Heat sensitive channel TRPV3 (trembl)


Arbutin

A monosaccharide derivative that is  hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.


E0V9R7_PEDHC Cytochrome P-450, putative (trembl)


E0VAD1_PEDHC Cytochrome P-450, putative (trembl)


E0VBK5_PEDHC Cytochrome P450, putative (trembl)


E0VCA5_PEDHC Cytochrome P450, putative (trembl)


E0VCW9_PEDHC Cytochrome P-450, putative (trembl)


E0VDM3_PEDHC Cytochrome P450, putative (trembl)


E0VDR0_PEDHC Cytochrome P450, putative (trembl)


E0VED4_PEDHC Cytochrome P-450, putative (trembl)


E0VGV6_PEDHC Cytochrome P450, putative (trembl)


E0VHL8_PEDHC Cytochrome P450, putative (trembl)


E0VHZ1_PEDHC Cytochrome P450, putative (trembl)


E0VJJ0_PEDHC Cytochrome P450, putative (trembl)


E0VM29_PEDHC Cytochrome P-450, putative (trembl)


E0VMV6_PEDHC Cytochrome P-450, putative (trembl)


E0VMV7_PEDHC Cytochrome P-450, putative (trembl)


E0VMW9_PEDHC Cytochrome P450, putative (trembl)


E0VQ45_PEDHC Cytochrome P-450, putative (trembl)


E0VQ46_PEDHC Cytochrome P-450, putative (trembl)


E0VQ47_PEDHC Cytochrome P-450, putative (trembl)


E0VRD2_PEDHC Cytochrome P-450, putative (trembl)


E0VSD4_PEDHC Cytochrome P450, putative (trembl)


E0VSD5_PEDHC Cytochrome P450, putative (trembl)


E0VUR0_PEDHC Cytochrome P450, putative (trembl)


E0VUR1_PEDHC Cytochrome P-450, putative (trembl)


E0VV39_PEDHC Cytochrome P-450, putative (trembl)


E0VV52_PEDHC Cytochrome P450, putative (trembl)


E0VV70_PEDHC Cytochrome P-450, putative (trembl)


E0VV72_PEDHC Cytochrome P-450, putative (trembl)


E0VXT9_PEDHC Cytochrome P450, putative (trembl)


E0VZW4_PEDHC Cytochrome P-450, putative (trembl)


E0W115_PEDHC Cytochrome P-450, putative (trembl)


E0W2B1_PEDHC Cytochrome P450, putative (trembl)


E0W389_PEDHC Cytochrome P-450, putative (trembl)


E0W4F7_PEDHC NADH-Ubiquinone oxidoreductase 39kDa subunit (trembl)


TRPA1_RAT Transient receptor potential cation channel subfamily A member 1 (sprot)

A transient receptor potential cation channel TRPA1 that is encoded in the genome of rat.


CP3A7_HUMAN Cytochrome P450 3A7 (sprot)

A cytochrome P450 3A7 that is encoded in the genome of human.


CP343_HUMAN Cytochrome P450 3A43 (sprot)

A cytochrome P450 3A43 that is encoded in the genome of human.


SC5A2_HUMAN Sodium/glucose cotransporter 2 (sprot)

A sodium/glucose cotransporter 2 that is encoded in the genome of human.


SC5A1_HUMAN Sodium/glucose cotransporter 1 (sprot)

A sodium/glucose cotransporter 1 that is encoded in the genome of human.


SC5A2_RAT Sodium/glucose cotransporter 2 (sprot)

A sodium/glucose cotransporter 2 that is encoded in the genome of rat.


SC5AB_HUMAN Sodium/myo-inositol cotransporter 2 (sprot)

A sodium/myo-inositol cotransporter 2 that is encoded in the genome of human.


SC5A4_HUMAN Probable glucose sensor protein SLC5A4 (sprot)

A solute carrier family 5 member 4 that is encoded in the genome of human.


DPYL2_HUMAN Dihydropyrimidinase-related protein 2 (sprot)

A dihydropyrimidinase-related protein 2 that is encoded in the genome of human.


Acriflavine

3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-acridinediamine. Fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication.

A mixture comprising 3,6-diamino-10-methylacridinium chloride (usually 60-70%) and 3,6-diaminoacridine monohydrochloride (usually 40-30%).


GPR39_HUMAN G-protein coupled receptor 39 (sprot)

A G-protein coupled receptor 39 that is encoded in the genome of human.


A6QR73_RAT G protein-coupled receptor 39-1b (trembl)


UBE2T_HUMAN Ubiquitin-conjugating enzyme E2 T (sprot)

A ubiquitin-conjugating enzyme E2 T that is encoded in the genome of human.


CLK3_HUMAN Dual specificity protein kinase CLK3 (sprot)

A dual specificity protein kinase CLK3 that is encoded in the genome of human.


PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (sprot)

A serine/threonine-protein kinase PAK 2 that is encoded in the genome of human.


E2AK1_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 1 (sprot)

A eukaryotic translation initiation factor 2-alpha kinase 1 that is encoded in the genome of human.


Cetrimonium Bromide

The organic bromide salt that is the bromide salt of cetyltrimethylammonium; one of the components of the topical antiseptic cetrimide.


Chiniofonum

The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.


CNGA1_HUMAN cGMP-gated cation channel alpha-1 (sprot)

A cGMP-gated cation channel alpha-1 that is encoded in the genome of human.


CNGA2_HUMAN Cyclic nucleotide-gated olfactory channel (sprot)

A cyclic nucleotide-gated olfactory channel that is encoded in the genome of human.


Clofenotane

synthetic insecticide used to combat malaria, typhus, and the other insect-borne human diseases

A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.


TPOR_HUMAN Thrombopoietin receptor (sprot)

A thrombopoietin receptor that is encoded in the genome of human.


CXCR4_HUMAN C-X-C chemokine receptor type 4 (sprot)

A C-X-C chemokine receptor type 4 that is encoded in the genome of human.


SDF1_HUMAN Stromal cell-derived factor 1 (sprot)

A stromal cell-derived factor 1 that is encoded in the genome of human.


CXCR4_RAT C-X-C chemokine receptor type 4 (sprot)

A C-X-C chemokine receptor type 4 that is encoded in the genome of rat.


ACKR3_HUMAN Atypical chemokine receptor 3 (sprot)

An atypical chemokine receptor 3 that is encoded in the genome of human.


Dibutyl Phthalate

A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.

A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of  butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.


Dihydroergocryptine

A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position and an alpha-isobutyl sidechain at 5'alpha position of the molecule.

alpha-Ergocryptine in which a single bond replaces the double bond between positions 9 and 10.


Levonordefrin

A catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry.


Hydrocortisone valerate

used in treatment of atopic dermatitis; RN given refers to 11beta-isomer


PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (sprot)

A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of human.


PTH2R_HUMAN Parathyroid hormone 2 receptor (sprot)

A parathyroid hormone 2 receptor that is encoded in the genome of human.


PTH2R_RAT Parathyroid hormone 2 receptor (sprot)

A parathyroid hormone 2 receptor that is encoded in the genome of rat.


PTH1R_RAT Parathyroid hormone/parathyroid hormone-related peptide receptor (sprot)

A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of rat.


ACTHR_HUMAN Adrenocorticotropic hormone receptor (sprot)

An adrenocorticotropic hormone receptor that is encoded in the genome of human.


Fenbendazole

Antinematodal benzimidazole used in veterinary medicine.

A member of the class of benzimidazoles that is 1H-benzimidazole  which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.


Q6RY99_RAT Gamma-hydroxybutyrate receptor (trembl)


Hydrochloric Acid

A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.

A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.


Iclaprim

An aminopyrimidine that is 5-methylpyrimidine-2,4-diamine in which one of the hydrogens of the methyl group has been replaced by a 2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl group.


KCNQ3_RAT Potassium voltage-gated channel subfamily KQT member 3 (sprot)

A voltage-gated potassium channel subunit KCNQ3 that is encoded in the genome of rat.


Diosmetin

A monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities.


TRYPAN BLUE FREE ACID

A diazo-naphthalene sulfonate that is widely used as a stain.

An aminonaphthalenesulfonic acid that is the free acid form of trypan blue dye.


Stearic Acid

A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and  plastics.


Piceid

A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue.


N-ACETYL-beta-D-GLUCOSAMINE

An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.


KLRBA_RAT Killer cell lectin-like receptor subfamily B member 1A (sprot)

A protein that is a translation product of the Klrb1a gene in rat.


Linolenic Acid

A fatty acid that is found in plants and involved in the formation of prostaglandins.

A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.


Levomenol

drug combination containing chamomile and bisabolol; used to treat dermatitis


GUC2C_RAT Guanylyl cyclase C (sprot)

A guanylyl cyclase C that is encoded in the genome of rat.


GUC2C_HUMAN Guanylyl cyclase C (sprot)

A guanylyl cyclase C that is encoded in the genome of human.


E0VB18_PEDHC Acetylcholine receptor protein alpha 1, 2, 3, 4 invertebrate, putative (trembl)


E0VB20_PEDHC Acetylcholine receptor protein alpha 1, 2, 3, 4 invertebrate, putative (trembl)


E0VDF4_PEDHC Acetylcholine receptor protein alpha 1, 2, 3, 4 invertebrate, putative (trembl)


E0VDF5_PEDHC Acetylcholine receptor protein subunit alpha-L1, putative (trembl)


E0VDF7_PEDHC Acetylcholine receptor protein alpha 1, 2, 3, 4 invertebrate, putative (trembl)


E0VP62_PEDHC DrosGluCl, putative (trembl)


CCKAR_CAVPO Cholecystokinin receptor type A (sprot)

A protein that is a translation product of the CCKAR gene in guinea pig.


KLK3_HUMAN Prostate-specific antigen (sprot)

A prostate-specific antigen that is encoded in the genome of human.


Tetrasodium pyrophosphate

An inorganic sodium salt comprised of a diphosphate(4-) anion and four sodium(1+) cations. More commonly known as tetrasodium pyrophosphate, it finds much use in the food industry as an emulsifier and in dental hygiene as a calcium-chelating salt.


Choline C-11

A choline in which one of the methyl carbons is replaced by an (11)C isotope. An intravenous radioactive diagnostic agent used (in the form of its chloride salt) as a tracer during positron emission tomography scans to help detect sites of recurrent prostate cancer.


A bright bluish pink compound that has been used as a dye, biological stain, and diagnostic aid.

A xanthene dye that is fluorescein bearing bromine substituents at positions 2', 4', 5' and 7' (on the xanthene ring) and iodine substituents at position 2, 3, 4, and 5 (on the phenyl ring). The dipotassium salt is the biological stain 'rose bengal'.


BGAL_HUMAN Beta-galactosidase (sprot)

A eukaryotic-type beta-galactosidase that is encoded in the genome of human.


SECA1_STAA8 Protein translocase subunit SecA 1 (sprot)

A protein translocase subunit SecA that is encoded in the genome of Staphylococcus aureus subsp. aureus NCTC 8325.


SECA2_STAA8 Protein translocase subunit SecA 2 (sprot)

A protein that is a translation product of the secA2 gene in Staphylococcus aureus subsp. aureus NCTC 8325.


PARG_HUMAN Poly(ADP-ribose) glycohydrolase (sprot)

A poly(ADP-ribose) glycohydrolase that is encoded in the genome of human.


Lauric Acid

A straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.


Eugenol

A cinnamate derivative of the shikamate pathway found in CLOVE OIL and other PLANTS.

A phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group. It is a major component of clove essential oil, and exhibits antibacterial, analgesic and antioxidant properties. It has been widely used in dentistry to treat toothache and pulpitis.


TEDISAMIL

A member of the class of diazabicyclononanes that is (1s,5s)-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1'-cyclopentane] in which the hydrogens at positions 3 and 7 are replaced by cyclopropylmethyl groups. It is a potassium channel blocker and an antiarrhythmic agent currently currently in development for the treatment of atrial fibrillation.


OX1R_HUMAN Orexin/Hypocretin receptor type 1 (sprot)

An orexin/hypocretin receptor type 1 that is encoded in the genome of human.


Paraoxon

An organophosphate cholinesterase inhibitor that is used as a pesticide.

An aryl dialkyl phosphate where both the alkyl groups are ethyl and the aryl group is 4-nitrophenyl.


MGLL_MOUSE Monoglyceride lipase (sprot)

A monoglyceride lipase that is encoded in the genome of mouse.


FAAH1_MOUSE Fatty-acid amide hydrolase 1 (sprot)

A fatty-acid amide hydrolase 1 that is encoded in the genome of mouse.


Q7T664_HRV1A Genome polyprotein (Fragment) (trembl)


Remikiren

renin inhibitor under development for the treatment of hypertension

An L-histidine derivative that is L-histidine in which one of the amino hydrogens is replaced by a (2S)-2-[(2-methylpropane-2-sulfonyl)methyl]-3-phenylpropanoyl group and the carboxy group is replaced by a [(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]amino group. It is a renin inhibitor which was under development for the treatment of hypertension (now discontinued).


Esatenolol

The (S)-enantiomer of atenolol.


SEMUSTINE

4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.


JAK3_MOUSE Tyrosine-protein kinase JAK3 (sprot)

A tyrosine-protein kinase JAK3 that is encoded in the genome of mouse.


JAK3_RAT Tyrosine-protein kinase JAK3 (sprot)

A tyrosine-protein kinase JAK3 that is encoded in the genome of rat.


JAK2_RAT Tyrosine-protein kinase JAK2 (sprot)

A tyrosine-protein kinase JAK2 that is encoded in the genome of rat.


DDX1_HUMAN ATP-dependent RNA helicase DDX1 (sprot)

An ATP-dependent RNA helicase DDX1 that is encoded in the genome of human.


GLP2R_HUMAN Glucagon-like peptide 2 receptor (sprot)

A glucagon-like peptide 2 receptor that is encoded in the genome of human.


GLP2R_RAT Glucagon-like peptide 2 receptor (sprot)

A glucagon-like peptide 2 receptor that is encoded in the genome of rat.


Daunorubicinol

The (13S)-diastereomer of 13-dihydrodaunorubicin.


MTP_HUMAN Microsomal triglyceride transfer protein large subunit (sprot)

A microsomal triglyceride transfer protein large subunit that is encoded in the genome of human.


PGH1_RABIT Prostaglandin G/H synthase 1 (sprot)

A prostaglandin G/H synthase 1 that is encoded in the genome of rabbit.


PGH2_RABIT Prostaglandin G/H synthase 2 (sprot)


KCNJ4_HUMAN Inward rectifier potassium channel 4 (sprot)

An inward rectifier potassium channel 4 that is encoded in the genome of human.


ATPL_MYCTU ATP synthase subunit c (sprot)

A protein that is a translation product of the atpE gene in Mycobacterium tuberculosis H37Rv.


ATPB_MYCTU ATP synthase subunit beta (sprot)

An ATP synthase subunit beta, mitochondrial that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


ATPA_MYCTU ATP synthase subunit alpha (sprot)

An ATP synthase subunit alpha, mitochondrial that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


ATPG_MYCTU ATP synthase gamma chain (sprot)

An ATP synthase subunit gamma, mitochondrial that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


ATPE_MYCTU ATP synthase epsilon chain (sprot)

A protein that is a translation product of the atpC gene in Mycobacterium tuberculosis H37Rv.


ATPFD_MYCTU ATP synthase subunit b-delta (sprot)

A protein that is a translation product of the atpFH gene in Mycobacterium tuberculosis H37Rv.


ATPF_MYCTU ATP synthase subunit b (sprot)

An ATP synthase subunit b that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


ATP6_MYCTU ATP synthase subunit a (sprot)

An ATP synthase subunit a that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


Q5TIX5_MYCSM ATP synthase subunit c (trembl)


ATPL_BACP3 ATP synthase subunit c (sprot)


ANO1_HUMAN Anoctamin-1 (sprot)

An anoctamin-1 that is encoded in the genome of human.


KEAP1_HUMAN Kelch-like ECH-associated protein 1 (sprot)

A kelch-like ECH-associated protein 1 that is encoded in the genome of human.


Ethylparaben

An ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol,


Ridaforolimus

an mTOR inhibitor for the treatment of cancer


Sodium propionate

An organic sodium salt comprising equal numbers of sodium and propionate ions.


FFAR3_RAT Free fatty acid receptor 3 (sprot)

A free fatty acid receptor 3 that is encoded in the genome of rat.


NEK1_HUMAN Serine/threonine-protein kinase Nek1 (sprot)

A serine/threonine-protein kinase Nek1 that is encoded in the genome of human.


ERN2_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE2 (sprot)

A serine/threonine-protein kinase/endoribonuclease IRE2 that is encoded in the genome of human.


P89582_9HIV2 Integrase (Fragment) (trembl)


PXL2A_HUMAN Peroxiredoxin-like 2A (sprot)

A peroxiredoxin-like 2A that is encoded in the genome of human.


NR4A3_HUMAN Nuclear receptor subfamily 4 group A member 3 (sprot)

A nuclear receptor subfamily 4 group A member 3 that is encoded in the genome of human.


Q6GYR8_9HEPC Genome polyprotein (trembl)


NRAM_I18A0 Neuraminidase (sprot)

A neuraminidase subtype N1 (Influenza A virus) that is encoded in the genome of the H1N1 strain A/Brevig Mission/1/1918.


LEPR_HUMAN Leptin receptor (sprot)

A leptin receptor that is encoded in the genome of human.


SC5A9_HUMAN Sodium/glucose cotransporter 4 (sprot)

A sodium/glucose cotransporter 4 that is encoded in the genome of human.


SC5AA_HUMAN Sodium/mannose cotransporter SLC5A10 (sprot)

A sodium/glucose cotransporter 5 that is encoded in the genome of human.


MC3R_MOUSE Melanocortin receptor 3 (sprot)

A melanocortin receptor 3 that is encoded in the genome of mouse.


MC5R_MOUSE Melanocortin receptor 5 (sprot)

A melanocortin receptor 5 that is encoded in the genome of mouse.


MC4R_MOUSE Melanocortin receptor 4 (sprot)

A melanocortin receptor 4 that is encoded in the genome of mouse.


MSHR_MOUSE Melanocyte-stimulating hormone receptor (sprot)

A melanocyte-stimulating hormone receptor that is encoded in the genome of mouse.


MSHR_HUMAN Melanocyte-stimulating hormone receptor (sprot)

A melanocyte-stimulating hormone receptor that is encoded in the genome of human.


GHR_HUMAN Growth hormone receptor (sprot)

A growth hormone receptor that is encoded in the genome of human.


Cridanimod

A small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Upon intramuscular administration, cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells. In addition, this agent is able to increase the production and release of interferon (IFN) alpha and beta. PR is often downregulated in endometrial cancer and makes it resistant to progestin-mediated hormone therapy.


STING_MOUSE Stimulator of interferon genes protein (sprot)

A transmembrane protein 173 that is encoded in the genome of mouse.


Corticorelin

A corticotropin-releasing hormone from human/rat composed of Ser, Glu, Glu, Pro, Pro, Ile, Ser, Leu, Asp, Leu, Val, Phe, His, Leu, Leu, Arg, Glu, Val, Leu, Glu, Met, Ala, Arg, Ala, Glu, Gln, Leu, Ala, Gln, Gln, Ala, His, Ser, Asn, Arg, Lys, Leu, Met, Glu, Ile and Ile-NH2 residues joined in sequence.


CRFR2_MOUSE Corticotropin-releasing factor receptor 2 (sprot)

A corticotropin-releasing factor receptor 2 that is encoded in the genome of mouse.


CRFR2_RAT Corticotropin-releasing factor receptor 2 (sprot)

A corticotropin-releasing factor receptor 2 that is encoded in the genome of rat.


CRFR2_HUMAN Corticotropin-releasing factor receptor 2 (sprot)

A corticotropin-releasing factor receptor 2 that is encoded in the genome of human.


CRFR1_HUMAN Corticotropin-releasing factor receptor 1 (sprot)

A corticotropin-releasing factor receptor 1 that is encoded in the genome of human.


4-Amino-3-phenylbutanoic acid

phenyl deriv of GABA; RN given refers to cpd without isomeric designation; structure


ETV6_HUMAN Transcription factor ETV6 (sprot)

A transcription factor ETV6 that is encoded in the genome of human.


HEMA_I34A1 Hemagglutinin (sprot)

A hemagglutinin subtype H1 (Influenza A virus) that is encoded in the genome of the H1N1 strain A/Puerto Rico/8/1934.


PAR1_HUMAN Proteinase-activated receptor 1 (sprot)

A proteinase-activated receptor 1 that is encoded in the genome of human.


F2SHH3_TRIRC Cytochrome P450 51 (trembl)


Q5L478_9HEPC Nonstructural protein 5A (Fragment) (trembl)


SYLC_YEAST Leucine--tRNA ligase, cytoplasmic (sprot)

A leucine--tRNA ligase, cytoplasmic that is encoded in the genome of yeast.


F2SF18_TRIRC leucine--tRNA ligase (trembl)


PK3C3_HUMAN Phosphatidylinositol 3-kinase catalytic subunit type 3 (sprot)

A phosphatidylinositol 3-kinase catalytic subunit type 3 that is encoded in the genome of human.


PK3CB_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (sprot)

A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform that is encoded in the genome of human.


OX2R_MOUSE Orexin receptor type 2 (sprot)

An orexin receptor type 2 that is encoded in the genome of mouse.


OX1R_MOUSE Orexin/Hypocretin receptor type 1 (sprot)

An orexin/hypocretin receptor type 1 that is encoded in the genome of mouse.


OX2R_HUMAN Orexin receptor type 2 (sprot)

An orexin receptor type 2 that is encoded in the genome of human.


LIPP_RAT Pancreatic triacylglycerol lipase (sprot)

A pancreatic triacylglycerol lipase that is encoded in the genome of rat.


SC5A1_MOUSE Sodium/glucose cotransporter 1 (sprot)

A sodium/glucose cotransporter 1 that is encoded in the genome of mouse.


SC5A1_RAT Sodium/glucose cotransporter 1 (sprot)

A sodium/glucose cotransporter 1 that is encoded in the genome of rat.


SC5A2_MOUSE Sodium/glucose cotransporter 2 (sprot)

A sodium/glucose cotransporter 2 that is encoded in the genome of mouse.


TYPH_ECOLI Thymidine phosphorylase (sprot)

A thymidine phosphorylase that is encoded in the genome of Escherichia coli K-12.


TYPH_HUMAN Thymidine phosphorylase (sprot)

A thymidine phosphorylase that is encoded in the genome of human.


KGP1_HUMAN cGMP-dependent protein kinase 1 (sprot)

A cGMP-dependent protein kinase 1 that is encoded in the genome of human.


PARP4_HUMAN Protein mono-ADP-ribosyltransferase PARP4 (sprot)

A protein mono-ADP-ribosyltransferase PARP4 that is encoded in the genome of human.


PAR10_HUMAN Protein mono-ADP-ribosyltransferase PARP10 (sprot)

A protein mono-ADP-ribosyltransferase PARP10 that is encoded in the genome of human.


PAR12_HUMAN Protein mono-ADP-ribosyltransferase PARP12 (sprot)

A protein mono-ADP-ribosyltransferase PARP12 that is encoded in the genome of human.


PAR15_HUMAN Protein mono-ADP-ribosyltransferase PARP15 (sprot)

A protein mono-ADP-ribosyltransferase PARP15 that is encoded in the genome of human.


PARP6_HUMAN Protein mono-ADP-ribosyltransferase PARP6 (sprot)

A protein mono-ADP-ribosyltransferase PARP6 that is encoded in the genome of human.


PAR16_HUMAN Protein mono-ADP-ribosyltransferase PARP16 (sprot)

A protein mono-ADP-ribosyltransferase PARP16 that is encoded in the genome of human.


TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (sprot)

A poly [ADP-ribose] polymerase tankyrase-1 that is encoded in the genome of human.


PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (sprot)

A poly [ADP-ribose] polymerase 2 that is encoded in the genome of human.


PARP3_HUMAN Protein mono-ADP-ribosyltransferase PARP3 (sprot)

A protein mono-ADP-ribosyltransferase PARP3 that is encoded in the genome of human.


CD52_HUMAN CAMPATH-1 antigen (sprot)

A CAMPATH-1 antigen that is encoded in the genome of human.


CD19_HUMAN B-lymphocyte antigen CD19 (sprot)

A CD19 molecule that is encoded in the genome of human.


CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain (sprot)

A CD3 epsilon that is encoded in the genome of human.


CD3G_HUMAN T-cell surface glycoprotein CD3 gamma chain (sprot)

A CD3 gamma that is encoded in the genome of human.


CD3D_HUMAN T-cell surface glycoprotein CD3 delta chain (sprot)

A CD3 delta that is encoded in the genome of human.


PLGF_HUMAN Placenta growth factor (sprot)

A placenta growth factor that is encoded in the genome of human.


VEGFB_HUMAN Vascular endothelial growth factor B (sprot)

A vascular endothelial growth factor B that is encoded in the genome of human.


PDCD1_HUMAN Programmed cell death protein 1 (sprot)

A programmed cell death protein 1 that is encoded in the genome of human.


FSHR_HUMAN Follicle-stimulating hormone receptor (sprot)

A follitropin receptor that is encoded in the genome of human.


TSHR_HUMAN Thyrotropin receptor (sprot)

A thyrotropin receptor that is encoded in the genome of human.


ACTHR_MOUSE Adrenocorticotropic hormone receptor (sprot)

An adrenocorticotropic hormone receptor that is encoded in the genome of mouse.


IL6RA_HUMAN Interleukin-6 receptor subunit alpha (sprot)

An interleukin-6 receptor subunit alpha that is encoded in the genome of human.


IL6RB_HUMAN Interleukin-6 receptor subunit beta (sprot)

An interleukin-6 receptor subunit beta that is encoded in the genome of human.


IL17_HUMAN Interleukin-17A (sprot)

An interleukin-17A that is encoded in the genome of human.


FUS_HRSVA Fusion glycoprotein F0 (sprot)


ACOX3_HUMAN Peroxisomal acyl-coenzyme A oxidase 3 (sprot)

A peroxisomal acyl-coenzyme A oxidase 3 that is encoded in the genome of human.


ACOX1_HUMAN Peroxisomal acyl-coenzyme A oxidase 1 (sprot)

A peroxisomal acyl-coenzyme A oxidase 1 that is encoded in the genome of human.


K7XJL6_9HEPC Genome polyprotein (Fragment) (trembl)


IL2RA_HUMAN Interleukin-2 receptor subunit alpha (sprot)

An interleukin-2 receptor subunit alpha that is encoded in the genome of human.


CCNA2_HUMAN Cyclin-A2 (sprot)

A cyclin-A2 that is encoded in the genome of human.


PI42A_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (sprot)

A phosphatidylinositol 5-phosphate 4-kinase type-2 alpha that is encoded in the genome of human.


M3K6_HUMAN Mitogen-activated protein kinase kinase kinase 6 (sprot)

A mitogen-activated protein kinase kinase kinase 6 that is encoded in the genome of human.


TN13B_HUMAN Tumor necrosis factor ligand superfamily member 13B (sprot)

A tumor necrosis factor ligand superfamily member 13B that is encoded in the genome of human.


CD20_HUMAN B-lymphocyte antigen CD20 (sprot)

A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human.


IL1B_HUMAN Interleukin-1 beta (sprot)

An interleukin-1 beta that is encoded in the genome of human.


IL2RB_HUMAN Interleukin-2 receptor subunit beta (sprot)

An interleukin-2 receptor subunit beta that is encoded in the genome of human.


IL2RG_HUMAN Cytokine receptor common subunit gamma (sprot)

A cytokine receptor common subunit gamma that is encoded in the genome of human.


CTLA4_HUMAN Cytotoxic T-lymphocyte protein 4 (sprot)

A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of human.


PAG_BACAN Protective antigen (sprot)

A protein that is a translation product of the pagA gene in Bacillus anthracis.


TNR8_HUMAN Tumor necrosis factor receptor superfamily member 8 (sprot)

A tumor necrosis factor receptor superfamily member 8 that is encoded in the genome of human.


TNF11_HUMAN Tumor necrosis factor ligand superfamily member 11 (sprot)

A tumor necrosis factor ligand superfamily member 11 that is encoded in the genome of human.


IL12A_HUMAN Interleukin-12 subunit alpha (sprot)

An interleukin-12 subunit alpha that is encoded in the genome of human.


IL12B_HUMAN Interleukin-12 subunit beta (sprot)

An interleukin-12 subunit beta that is encoded in the genome of human.


IL23A_HUMAN Interleukin-23 subunit alpha (sprot)

An interleukin-23 subunit alpha that is encoded in the genome of human.


ITA4_HUMAN Integrin alpha-4 (sprot)

An integrin alpha-4 that is encoded in the genome of human.


ITB1_HUMAN Integrin beta-1 (sprot)

An integrin beta-1 that is encoded in the genome of human.


ITB7_HUMAN Integrin beta-7 (sprot)

An integrin beta-7 that is encoded in the genome of human.


IGHE_HUMAN Immunoglobulin heavy constant epsilon (sprot)

An immunoglobulin heavy constant epsilon that is encoded in the genome of human.


CD33_HUMAN Myeloid cell surface antigen CD33 (sprot)

A CD33 molecule that is encoded in the genome of human.


CSF3R_HUMAN Granulocyte colony-stimulating factor receptor (sprot)

A granulocyte colony-stimulating factor receptor that is encoded in the genome of human.


SDIS_PSEPU Steroid Delta-isomerase (sprot)


PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (sprot)

A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of human.


INSR_RAT Insulin receptor (sprot)

An insulin receptor that is encoded in the genome of rat.


IL1AP_HUMAN Interleukin-1 receptor accessory protein (sprot)

An interleukin-1 receptor accessory protein that is encoded in the genome of human.


CSF2R_HUMAN Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (sprot)

A granulocyte-macrophage colony-stimulating factor receptor subunit alpha that is encoded in the genome of human.


IL3RB_HUMAN Cytokine receptor common subunit beta (sprot)

A cytokine receptor common subunit beta that is encoded in the genome of human.


I11RA_HUMAN Interleukin-11 receptor subunit alpha (sprot)

An interleukin-11 receptor subunit alpha that is encoded in the genome of human.


Tannic Acid

Any of a group of astringent polyphenolic vegetable principles or compounds, chiefly complex glucosides of catechol and pyrogallol.


LTC4S_CAVPO Leukotriene C4 synthase (sprot)


ARP3_HUMAN Actin-related protein 3 (sprot)

An actin-related protein 3 that is encoded in the genome of human.


CATC_HUMAN Dipeptidyl peptidase 1 (sprot)

A dipeptidyl peptidase 1 that is encoded in the genome of human.


SYCC_HUMAN Cysteine--tRNA ligase, cytoplasmic (sprot)

A cysteine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


EGFR_MOUSE Epidermal growth factor receptor (sprot)

An epidermal growth factor receptor that is encoded in the genome of mouse.


SLAF7_HUMAN SLAM family member 7 (sprot)

A SLAM family member 7 that is encoded in the genome of human.


CD2_HUMAN T-cell surface antigen CD2 (sprot)

A CD2 molecule that is encoded in the genome of human.


CD80_HUMAN T-lymphocyte activation antigen CD80 (sprot)

A CD80 molecule that is encoded in the genome of human.


CD86_HUMAN T-lymphocyte activation antigen CD86 (sprot)

A CD86 molecule that is encoded in the genome of human.


IL1A_HUMAN Interleukin-1 alpha (sprot)

An interleukin-1 alpha that is encoded in the genome of human.


IL1RA_HUMAN Interleukin-1 receptor antagonist protein (sprot)

An interleukin-1 receptor antagonist protein that is encoded in the genome of human.


LPH_RAT Lactase/phlorizin hydrolase (sprot)

A lactase/phlorizin hydrolase that is encoded in the genome of rat.


AGALC_ASPNG Alpha-galactosidase C (sprot)


AGAL_HUMAN Alpha-galactosidase A (sprot)

An alpha-galactosidase A that is encoded in the genome of human.


Chromium chloride (CrCl3)

Trivalent chromium is part of glucose tolerance factor, an activator of insulin-mediated reactions. Chromium helps to maintain normal glucose metabolism and peripheral nerve function.

A chromium chloride with the chromium cation in the +3 oxidation state.


INAR1_HUMAN Interferon alpha/beta receptor 1 (sprot)

An interferon-alpha/beta receptor alpha chain that is encoded in the genome of human.


INAR2_HUMAN Interferon alpha/beta receptor 2 (sprot)

An interferon alpha/beta receptor 2 that is encoded in the genome of human.


COMT_MOUSE Catechol O-methyltransferase (sprot)

A catechol O-methyltransferase that is encoded in the genome of mouse.


PD1L1_HUMAN Programmed cell death 1 ligand 1 (sprot)

A programmed cell death 1 ligand 1 that is encoded in the genome of human.


ICAM1_HUMAN Intercellular adhesion molecule 1 (sprot)

An intercellular adhesion molecule 1 that is encoded in the genome of human.


ITB2_HUMAN Integrin beta-2 (sprot)

An integrin beta-2 that is encoded in the genome of human.


I17RA_HUMAN Interleukin-17 receptor A (sprot)

An interleukin-17 receptor A that is encoded in the genome of human.


I17RC_HUMAN Interleukin-17 receptor C (sprot)

An interleukin-17 receptor C that is encoded in the genome of human.


DMD_HUMAN Dystrophin (sprot)

A dystrophin that is encoded in the genome of human.


SEPT9_HUMAN Septin-9 (sprot)

A septin-9 that is encoded in the genome of human.


PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (sprot)

A protein mono-ADP-ribosyltransferase PARP14 that is encoded in the genome of human.


TNR1A_HUMAN Tumor necrosis factor receptor superfamily member 1A (sprot)

A tumor necrosis factor receptor superfamily member 1A that is encoded in the genome of human.


TPH1_HUMAN Tryptophan 5-hydroxylase 1 (sprot)

A tryptophan 5-hydroxylase 1 that is encoded in the genome of human.


O39930_9HEPC RNA-directed RNA polymerase (Fragment) (trembl)


IL4RA_HUMAN Interleukin-4 receptor subunit alpha (sprot)

An interleukin-4 receptor subunit alpha that is encoded in the genome of human.


PNPH_BOVIN Purine nucleoside phosphorylase (sprot)


PRKX_HUMAN cAMP-dependent protein kinase catalytic subunit PRKX (sprot)

A serine/threonine-protein kinase PRKX that is encoded in the genome of human.


TNR16_HUMAN Tumor necrosis factor receptor superfamily member 16 (sprot)

A tumor necrosis factor receptor superfamily member 16 that is encoded in the genome of human.


CD22_HUMAN B-cell receptor CD22 (sprot)

A B-cell receptor CD22 that is encoded in the genome of human.


IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (sprot)

An isocitrate dehydrogenase [NADP] cytoplasmic that is encoded in the genome of human.


IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial (sprot)

An isocitrate dehydrogenase [NADP], mitochondrial that is encoded in the genome of human.


ST32B_HUMAN Serine/threonine-protein kinase 32B (sprot)

A serine/threonine-protein kinase 32B that is encoded in the genome of human.


ADCK5_HUMAN Uncharacterized aarF domain-containing protein kinase 5 (sprot)

An uncharacterized aarF domain-containing protein kinase 5 that is encoded in the genome of human.


RB27A_HUMAN Ras-related protein Rab-27A (sprot)

A Ras-related protein Rab-27A that is encoded in the genome of human.


PEBP1_HUMAN Phosphatidylethanolamine-binding protein 1 (sprot)

A phosphatidylethanolamine-binding protein 1 that is encoded in the genome of human.


TRM1_HCMVM Tripartite terminase subunit 1 (sprot)


TRM2_HCMVM Tripartite terminase subunit 2 (sprot)


TRM3_HCMVM Tripartite terminase subunit 3 (sprot)


IL5RA_HUMAN Interleukin-5 receptor subunit alpha (sprot)

An interleukin-5 receptor subunit alpha that is encoded in the genome of human.


FA9_HUMAN Coagulation factor IX (sprot)

A coagulation factor IX that is encoded in the genome of human.


NTCP2_HUMAN Ileal sodium/bile acid cotransporter (sprot)

An ileal sodium/bile acid cotransporter that is encoded in the genome of human.


CD4_HUMAN T-cell surface glycoprotein CD4 (sprot)

A CD4 molecule that is encoded in the genome of human.


KIT_MOUSE Mast/stem cell growth factor receptor Kit (sprot)

A mast/stem cell growth factor receptor that is encoded in the genome of mouse.


NEK4_HUMAN Serine/threonine-protein kinase Nek4 (sprot)

A serine/threonine-protein kinase Nek4 that is encoded in the genome of human.


MYH10_HUMAN Myosin-10 (sprot)

A myosin-10 that is encoded in the genome of human.


CDKL1_HUMAN Cyclin-dependent kinase-like 1 (sprot)

A cyclin-dependent kinase-like 1 that is encoded in the genome of human.


FGF23_HUMAN Fibroblast growth factor 23 (sprot)

A fibroblast growth factor 23 that is encoded in the genome of human.


CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (sprot)

A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human.


TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 (sprot)

A transient receptor potential cation channel TRPV2 that is encoded in the genome of human.


TRPV4_RAT Transient receptor potential cation channel subfamily V member 4 (sprot)

A transient receptor potential cation channel TRPV4 that is encoded in the genome of rat.


PGRC1_HUMAN Membrane-associated progesterone receptor component 1 (sprot)

A membrane-associated progesterone receptor component 1 that is encoded in the genome of human.


PCY1A_HUMAN Choline-phosphate cytidylyltransferase A (sprot)

A choline-phosphate cytidylyltransferase A that is encoded in the genome of human.


PG057_VAR67 Envelope phospholipase OPG057 (sprot)


GNRHR_MACMU Gonadotropin-releasing hormone receptor (Fragment) (sprot)


U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (sprot)

A U5 small nuclear ribonucleoprotein 200 kDa helicase that is encoded in the genome of human.


CY1_HUMAN Cytochrome c1, heme protein, mitochondrial (sprot)

A cytochrome c1, heme protein, mitochondrial that is encoded in the genome of human.


PUR6_HUMAN Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (sprot)

A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is encoded in the genome of human.


EFTU_HUMAN Elongation factor Tu, mitochondrial (sprot)

An elongation factor Tu, mitochondrial that is encoded in the genome of human.


RAN_HUMAN GTP-binding nuclear protein Ran (sprot)

A GTP-binding nuclear protein Ran that is encoded in the genome of human.


DHC24_HUMAN Delta(24)-sterol reductase (sprot)

A Delta(24)-sterol reductase that is encoded in the genome of human.


RABL3_HUMAN Rab-like protein 3 (sprot)

A Rab-like protein 3 that is encoded in the genome of human.


PRPK_HUMAN EKC/KEOPS complex subunit TP53RK (sprot)

An EKC/KEOPS complex subunit TP53RK that is encoded in the genome of human.


ACSL5_HUMAN Long-chain-fatty-acid--CoA ligase 5 (sprot)

A long-chain-fatty-acid--CoA ligase 5 that is encoded in the genome of human.


VWF_HUMAN von Willebrand factor (sprot)

A von Willebrand factor that is encoded in the genome of human.


ADRB3_CANLF Beta-3 adrenergic receptor (sprot)

A beta-3 adrenergic receptor that is encoded in the genome of dog.


ADRB3_MACMU Beta-3 adrenergic receptor (sprot)


CALCA_HUMAN Calcitonin gene-related peptide 1 (sprot)


IL3RA_HUMAN Interleukin-3 receptor subunit alpha (sprot)

An interleukin-3 receptor class 2 alpha chain that is encoded in the genome of human.


S1PR2_HUMAN Sphingosine 1-phosphate receptor 2 (sprot)

A sphingosine 1-phosphate receptor 2 that is encoded in the genome of human.


PK3CB_RAT Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (sprot)

A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform that is encoded in the genome of rat.


KAPCG_HUMAN cAMP-dependent protein kinase catalytic subunit gamma (sprot)

A cAMP-dependent protein kinase catalytic subunit gamma that is encoded in the genome of human.


XPO1_HUMAN Exportin-1 (sprot)

An exportin-1 that is encoded in the genome of human.


SNP25_HUMAN Synaptosomal-associated protein 25 (sprot)

A synaptosomal-associated protein 25 that is encoded in the genome of human.


CD79B_HUMAN B-cell antigen receptor complex-associated protein beta chain (sprot)

A B-cell antigen receptor complex-associated protein beta chain that is encoded in the genome of human.


APOC3_HUMAN Apolipoprotein C-III (sprot)

An apolipoprotein C-III that is encoded in the genome of human.


LMTK3_HUMAN Serine/threonine-protein kinase LMTK3 (sprot)

A serine/threonine-protein kinase LMTK3 that is encoded in the genome of human.


BRDT_HUMAN Bromodomain testis-specific protein (sprot)

A bromodomain testis-specific protein that is encoded in the genome of human.


SL9A3_RAT Sodium/hydrogen exchanger 3 (sprot)

A sodium/hydrogen exchanger 3 that is encoded in the genome of rat.


SL9A3_HUMAN Sodium/hydrogen exchanger 3 (sprot)

A sodium/hydrogen exchanger 3 that is encoded in the genome of human.


G1C775_ACIBA Penicillin-binding protein 1A (trembl)


A6T4V3_KLEP7 Penicillin-binding protein 1B (trembl)


A0A0W8ASI8_KLEPN Peptidoglycan D,D-transpeptidase MrdA (trembl)


A6T4M7_KLEP7 Peptidoglycan D,D-transpeptidase FtsI (trembl)


FTSI_PSEAE Peptidoglycan D,D-transpeptidase FtsI (sprot)


D0CCM7_ACIB2 Peptidoglycan D,D-transpeptidase FtsI (trembl)


HEM1_HUMAN 5-aminolevulinate synthase, non-specific, mitochondrial (sprot)

A 5-aminolevulinate synthase, non-specific, mitochondrial that is encoded in the genome of human.


P2RX7_HUMAN P2X purinoceptor 7 (sprot)

A P2X purinoceptor 7 that is encoded in the genome of human.


P2RX7_MOUSE P2X purinoceptor 7 (sprot)

A P2X purinoceptor 7 that is encoded in the genome of mouse.


SOST_HUMAN Sclerostin (sprot)

A sclerostin that is encoded in the genome of human.


GDF11_HUMAN Growth/differentiation factor 11 (sprot)

A growth/differentiation factor 11 that is encoded in the genome of human.


GDF8_HUMAN Growth/differentiation factor 8 (sprot)

A growth/differentiation factor 8 that is encoded in the genome of human.


LYAM3_HUMAN P-selectin (sprot)

A P-selectin that is encoded in the genome of human.


NECT4_HUMAN Nectin-4 (sprot)

A nectin-4 that is encoded in the genome of human.


Q84406_PBCV1 Prolyl 4-hydroxylase (trembl)


EGLN2_HUMAN Prolyl hydroxylase EGLN2 (sprot)

A prolyl hydroxylase EGLN2 that is encoded in the genome of human.


EGLN3_HUMAN Prolyl hydroxylase EGLN3 (sprot)

A prolyl hydroxylase EGLN3 that is encoded in the genome of human.


Mefuparib

A member of the class of 1-benzofurans that is 1-benzofuran substituted by 4-[(methylamino)methyl]phenyl, fluoro and aminocarbonyl groups at positions 2, 5, and 7, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 3.2 nM and 1.9 nM, respectively). The compound exhibits anti-cancer properties and has also shown promising antiviral activity against the virus that causes COVID-19.


B5DFE2_RAT Histone-lysine N-methyltransferase EZH2 (trembl)


EZH1_HUMAN Histone-lysine N-methyltransferase EZH1 (sprot)

A histone-lysine N-methyltransferase EZH1 that is encoded in the genome of human.


EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (sprot)

A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of human.


ACLY_HUMAN ATP-citrate synthase (sprot)

An ATP-citrate synthase that is encoded in the genome of human.


C11B2_RAT Cytochrome P450 11B2, mitochondrial (sprot)

A cytochrome P450 11B that is a translation product of the Cyp11b2 gene in rat.


CALCB_HUMAN Calcitonin gene-related peptide 2 (sprot)

A calcitonin gene-related peptide 2 that is encoded in the genome of human.


SMC2_HUMAN Structural maintenance of chromosomes protein 2 (sprot)

A structural maintenance of chromosomes protein 2 that is encoded in the genome of human.


SMC1A_HUMAN Structural maintenance of chromosomes protein 1A (sprot)

A structural maintenance of chromosomes protein 1A that is encoded in the genome of human.


MYH14_HUMAN Myosin-14 (sprot)

A myosin-14 that is encoded in the genome of human.


FCGRN_HUMAN IgG receptor FcRn large subunit p51 (sprot)

An IgG receptor FcRn large subunit p51 that is encoded in the genome of human.


TACD2_HUMAN Tumor-associated calcium signal transducer 2 (sprot)

A tumor-associated calcium signal transducer 2 that is encoded in the genome of human.


FCG3A_HUMAN Low affinity immunoglobulin gamma Fc region receptor III-A (sprot)

A low affinity immunoglobulin gamma Fc region receptor III-A that is encoded in the genome of human.


CDD_HUMAN Cytidine deaminase (sprot)

A cytidine deaminase that is encoded in the genome of human.


CCR8_HUMAN C-C chemokine receptor type 8 (sprot)

A C-C chemokine receptor type 8 that is encoded in the genome of human.


FCGR1_HUMAN High affinity immunoglobulin gamma Fc receptor I (sprot)

A high affinity immunoglobulin gamma Fc receptor I that is encoded in the genome of human.


TNR17_HUMAN Tumor necrosis factor receptor superfamily member 17 (sprot)

A tumor necrosis factor receptor superfamily member 17 that is encoded in the genome of human.


RASN_HUMAN GTPase NRas (sprot)

A GTPase NRas that is encoded in the genome of human.


HAOX1_HUMAN 2-Hydroxyacid oxidase 1 (sprot)

A 2-hydroxyacid oxidase 1 that is encoded in the genome of human.


MC4R_RAT Melanocortin receptor 4 (sprot)

A melanocortin receptor 4 that is encoded in the genome of rat.


IGHG1_HUMAN Immunoglobulin heavy constant gamma 1 (sprot)

An immunoglobulin heavy constant gamma 1 that is encoded in the genome of human.


IGHG2_HUMAN Immunoglobulin heavy constant gamma 2 (sprot)

An immunoglobulin heavy constant gamma 2 that is encoded in the genome of human.


IGHG3_HUMAN Immunoglobulin heavy constant gamma 3 (sprot)

An immunoglobulin heavy constant gamma 3 that is encoded in the genome of human.


IGHG4_HUMAN Immunoglobulin heavy constant gamma 4 (sprot)

An immunoglobulin heavy constant gamma 4 that is encoded in the genome of human.


OGFD1_HUMAN Prolyl 3-hydroxylase OGFOD1 (sprot)

A prolyl 3-hydroxylase OGFOD1 that is encoded in the genome of human.


GCYB1_RAT Guanylate cyclase soluble subunit beta-1 (sprot)

A guanylate cyclase soluble subunit beta-1 that is encoded in the genome of rat.


NEK10_HUMAN Serine/threonine-protein kinase Nek10 (sprot)

A serine/threonine-protein kinase Nek10 that is encoded in the genome of human.


MOCS1_HUMAN Molybdenum cofactor biosynthesis protein 1 (sprot)

A molybdenum cofactor biosynthesis protein 1 that is encoded in the genome of human.


ANGL3_HUMAN Angiopoietin-related protein 3 (sprot)

An angiopoietin-related protein 3 that is encoded in the genome of human.


CO3_HUMAN Complement C3 (sprot)

A complement C3 that is encoded in the genome of human.


FOLH1_HUMAN Glutamate carboxypeptidase 2 (sprot)

A glutamate carboxypeptidase 2 that is encoded in the genome of human.


FGFR4_MOUSE Fibroblast growth factor receptor 4 (sprot)

A fibroblast growth factor receptor 4 that is encoded in the genome of mouse.


Q6FTN8_CANGA 1,3-beta-glucan synthase (trembl)


P87204_ASPFM 1,3-beta-glucan synthase (trembl)


EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (sprot)

An endothelial PAS domain-containing protein 1 that is encoded in the genome of human.


IL17F_HUMAN Interleukin-17F (sprot)

An interleukin-17F that is encoded in the genome of human.


IL13_HUMAN Interleukin-13 (sprot)

An interleukin-13 that is encoded in the genome of human.


ANPRB_HUMAN Atrial natriuretic peptide receptor 2 (sprot)

An atrial natriuretic peptide receptor 2 that is encoded in the genome of human.


TFR1_HUMAN Transferrin receptor protein 1 (sprot)

A transferrin receptor protein 1 that is encoded in the genome of human.


MPRI_HUMAN Cation-independent mannose-6-phosphate receptor (sprot)

A cation-independent mannose-6-phosphate receptor that is encoded in the genome of human.


C5AR1_HUMAN C5a anaphylatoxin chemotactic receptor 1 (sprot)

A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human.


UL97_HCMVA Serine/threonine protein kinase UL97 (sprot)


TSLP_HUMAN Thymic stromal lymphopoietin (sprot)

A thymic stromal lymphopoietin that is encoded in the genome of human.


Toluene

The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent.


NF2L2_HUMAN Nuclear factor erythroid 2-related factor 2 (sprot)

A nuclear factor erythroid 2-related factor 2 that is encoded in the genome of human.


KPYM_HUMAN Pyruvate kinase PKM (sprot)

A pyruvate kinase PKM that is encoded in the genome of human.


KPYR_HUMAN Pyruvate kinase PKLR (sprot)

A pyruvate kinase PKLR that is encoded in the genome of human.


Diprenorphine

A narcotic antagonist similar in action to NALOXONE. It is used to remobilize animals after ETORPHINE neuroleptanalgesia and is considered specific antagonist to etorphine


MYH7_HUMAN Myosin-7 (sprot)

A myosin-7 that is encoded in the genome of human.


PMEL_HUMAN Melanocyte protein PMEL (sprot)

A melanocyte protein Pmel 17 that is encoded in the genome of human.


LAG3_HUMAN Lymphocyte activation gene 3 protein (sprot)

A lymphocyte activation gene 3 protein that is encoded in the genome of human.


ANGP2_HUMAN Angiopoietin-2 (sprot)

An angiopoietin-2 that is encoded in the genome of human.


GIPR_HUMAN Gastric inhibitory polypeptide receptor (sprot)

A gastric inhibitory polypeptide receptor that is encoded in the genome of human.


GP119_HUMAN Glucose-dependent insulinotropic receptor (sprot)

A glucose-dependent insulinotropic receptor that is encoded in the genome of human.


GHR_RAT Growth hormone receptor (sprot)

A growth hormone receptor that is encoded in the genome of rat.


Dichlorvos

An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.


Amitraz

A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.


Ethopabate

An inhibitor of folate metabolism. It is used as coccidiostat in poultry


A narcotic analgesic morphinan used as sedative in veterinary practice


Firocoxib

An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in horses and dogs.


Flunixin

A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a 2-methyl-3-(trifluoromethyl)phenylamino group. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine (usually as the meglumine salt) for treatment of horses, cattle and pigs.


Fluprostenol

Synthetic prostaglandin alpha analog used as an abortifacient

An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea.


Grapiprant

A potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties


Amprolium

A veterinary coccidiostat that interferes with THIAMINE metabolism

An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.


Imidacloprid

Systemic contact insecticide exhibiting low mammalian toxicity. This neonicotinoid insecticide acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system

The E-isomer of imidacloprid.


Azaperone

A butyrophenone used in the treatment of PSYCHOSES

An N-arylpiperazine that is 2-(piperazin-1-yl)pyridine in which the amino hydrogen is replaced by a 3-(4-fluobenzoyl)propyl group. Used mainly as a tranquiliser for pigs and elephants.


Imidocarb

One of ANTIPROTOZOAL AGENTS used especially against BABESIA in livestock


Mibolerone

prevents estrus in animals prevents experimental lymphoid leukosis

An androgen that is nalandrone carrying two methyl substituents at positions 7alpha and 17.


Nitenpyram

A nitromethylene neonicotinoid insecticide

A nitenpyram in which the double bond has E configuration.


Oxfendazole

A member of the class of benzimidazoles that is fenbendazole in which the sulfur has been oxidised to the corresponding sulfoxide.


Phenothiazine

The 10H-tautomer of phenothiazine.


Ractopamine

A diastereoisomeric mixture of approximately equal amounts of all four possible diastereoisomers of 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol. A beta-adrenergic agonist, it is used (generally as the hydrochloride salt) as a feed additive for use in pigs and other livestock to promote protein deposition, resulting in leaner meat. The R,R diastereoisomer, butopamine, is responsible for most of the leanness-enhancing effects. While use of ractopamine has been banned in over 120 countries including throughout the EU, in the US it used in an estimated 80% of all beef, pork and turkey production.


Tepoxalin

A hydroxamic acid obtained by formal condensation of the carboxy group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid with the amino group of N-methylhydroxylamine. It is used in veterinary medicine for the control of pain and inflammation caused by musculoskeletal disorders such as hip dysplasia and arthritis in dogs.


Trenbolone acetate

An anabolic steroid used mainly as an anabolic agent in veterinary practice


Zilpaterol

Is an adrenergic drug currently licensed in Mexico and South Africa as feed additive for cattle close to consignment


Potassium Bromide

A metal bromide salt with a K(+) counterion.


A synthetic prostaglandin F2alpha analog. The compound has luteolytic effects and is used for the synchronization of estrus in cattle


Coumaphos

A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as nematocide


Deracoxib

A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3, and 5 by 4-sulfamoylphenyl, difluoromethyl and 3-fluoro-4-methoxyphenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs.


Deslorelin

Ovuplant is tradename for short-term-release implant containing deslorelin acetate


Grade 3 Intestinal Stoma Site Bleeding, CTCAE

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

Transfusion indicated; invasive intervention indicated


Intestinal Stoma Site Bleeding, CTCAE

A disorder characterized by bleeding from the intestinal stoma.


Grade 1 Intestinal Stoma Site Bleeding, CTCAE

Minimal bleeding identified on clinical exam; intervention not indicated


Grade 5 Intestinal Stoma Site Bleeding, CTCAE

Death


Grade 2 Intestinal Stoma Site Bleeding, CTCAE

Moderate bleeding; medical intervention indicated


Grade 4 Intestinal Stoma Site Bleeding, CTCAE

Life-threatening consequences; urgent intervention indicated


DNA-(apurinic or apyrimidinic site) endonuclease, initiator methionine removed form (human)

A DNA-(apurinic or apyrimidinic site) endonuclease (human) that has had the initiator methionine removed. UniProtKB:P27695, 2-318.


Obstructive Ureterocele

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

A ureterocele with a small, obstructive orifice.


ureterocele

A cystic and dysplastic dilation of the distal ureter within the bladder that may extend into the bladder neck and urethra.


Orthotopic ureterocele

A ureterocele that is located entirely within the bladder, and which may be associated with a single system, with the upper pole ureter of a completely duplicated system, or rarely associated with a lower pole ureter. (Adapted from Glassberg KI, Braren V, Duckett JW, Jacobs EC, King LR, Lebowitz RL et al. Suggested terminology for duplex systems, ectopic ureters and ureteroceles. J Urol 1984; 132(6):1153-1154.)


Sphincteric Ureterocele

A ureterocele in which the orifice is distal to the external urinary sphincter.


Cecoureterocele

A ureterocele in which the orifice is located in the bladder, with the ureterocele pouch extending submucosally into the urethra.


Ectopic ureterocele

A ureterocele in which some portion of the ureterocele is situated permanently at the bladder neck or in the urethra. The orifice may be situated in the bladder, at the bladder neck, or in the urethra. (Adapted from Glassberg KI, Braren V, Duckett JW, Jacobs EC, King LR, Lebowitz RL et al. Suggested terminology for duplex systems, ectopic ureters and ureteroceles. J Urol 1984; 132(6):1153-1154.)


eukaryotic translation initiation factor 4E phosphorylated 1 (human)

A eukaryotic translation initiation factor 4E (human) that has been phosphorylated on the residue at the position equivalent to Ser-53 of the amino acid sequence represented by UniProtKB:P06730-1. Example: UniProtKB:P06730-1, Ser-53, MOD:00046.


taurodontism

Taurodontism is a dental anomaly characterized by an elongated pulp chamber, displaced toward the apical floor of the tooth with no constriction at the level of the cemento-enamel junction, and short roots. It most frequently affects permanent molar teeth. Taurodontism increases the risk of pulp exposure. It can be isolated or associated with certain syndromes such as Down syndrome, amelogenesis imperfecta, and Klinefelter syndrome.


myasthenic syndrome, congenital, 23, presynaptic


serine/threonine-protein kinase VRK2 isoform h4 (human)

A serine/threonine-protein kinase VRK2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86Y07-4.


Postsurgical Stage II Hepatoblastoma

No metastases, tumor grossly resected with microscopic residual disease (i.e., positive margins); or tumor rupture, or tumor spill at the time of surgery. (from PDQ 2004)


potassium voltage-gated channel subfamily H member 5 isoform 3 (human)

A voltage-gated potassium channel KCNH5 isoform 3 that is encoded in the genome of human.


primary ciliary dyskinesia 4

A primary ciliary dyskinesia that is characterized by partial absence of the inner dynein arms with variable occurrence of situs inversus and has material basis in variation in the chromosome region 15q13.1-q15.1.


infantile diarrhea

Diarrhea occurring in infants from newborn to 24-months old.


Ulnar deviation of the 4th finger

Displacement of the 4th finger towards the ulnar side (i.e., towards the 5th finger).


Radial deviation of the 4th finger

Displacement of the 4th finger towards the radial side (i.e., towards the thumb).


Radial deviation of the 2nd finger

Displacement of the 2nd finger towards the radial side.


Ulnar deviation of thumb

Bending or curvature of a thumb towards the ulnar side (towards the ring finger).


Deviation of the 2nd finger

Displacement of the 2nd finger from its normal position.


Distally placed thumb

Insertion of thumb at a more distal location than normal.


Ulnar deviation of the 5th finger

Displacement of the 5th finger towards the ulnar side.


Radial deviation of the 3rd finger

Displacement of the 3rd finger towards the radial side (i.e., towards the thumb).


Ulnar deviation of the 2nd finger

Displacement of the 2nd (index) finger towards the ulnar side.


Hitchhiker thumb

With the hand relaxed and the thumb in the plane of the palm, the axis of the thumb forms an angle of at least 90 degrees with the long axis of the hand.


Ulnar deviation of finger

Bending or curvature of a finger toward the ulnar side (i.e., away from the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly.


Clinodactyly of the 5th finger

Clinodactyly refers to a bending or curvature of the fifth finger in the radial direction (i.e., towards the 4th finger).


Deviation of the 5th finger

Displacement of the 5th finger from its normal position.


Overlapping fingers

A finger resting on the dorsal surface of an adjacent digit when the hand is at rest.


Fifth finger distal phalanx clinodactyly

Bending or curvature of the distal phalanx of little finger in the radial direction (i.e., towards the 4th finger).


Proximal placement of thumb

Proximal mislocalization of the thumb.


Ulnar deviation of the 3rd finger

Displacement of the 3rd finger towards the ulnar side (i.e., towards the ring finger).


Radial deviation of finger

Bending or curvature of a finger toward the radial side (i.e., towards the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly.


Deviation of the thumb

Displacement of the thumb from its normal position.


Deviation of the 4th finger

Displacement of the 4th finger from its normal position.


Deviation of the 3rd finger

Displacement of the 3rd finger from its normal position.


Premature birth following premature rupture of fetal membranes


atrioventricular septal defect 4

Any atrioventricular septal defect in which the cause of the disease is a mutation in the GATA4 gene.


structural congenital heart disease, multiple types - GATA4

Any congenital heart disease in which the cause of the disease is a mutation in the GATA4 gene.


ventricular septal defect 1

Any ventricular septal defect in which the cause of the disease is a mutation in the GATA4 gene.


atrial septal defect 2

Any atrial heart septal defect in which the cause of the disease is a mutation in the GATA4 gene.


T-cell surface glycoprotein CD4 N-glycosylated 23 (human)

A T-cell surface glycoprotein CD4 (human) that has been N-glycosylated at the residue equivalent to Asn-296 of the amino acid sequence represented by UniProtKB:P01730-1, in which the glycan structure is represented by GlyTouCan:G65890UA. Example: UniProtKB:P01730-1, Asn-296, MOD:00160~GNO:G65890UA.


reactive arthritis

Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.


Stage IVC Laryngeal Cancer AJCC v8

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


head and neck carcinoma

A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.


Localized Parathyroid Gland Carcinoma

A parathyroid gland carcinoma that has not spread to other anatomic sites.


Nasopharyngeal Carcinoma by AJCC v7 Stage

A term that refers to the staging of nasopharyngeal carcinoma according to the American Joint Committee on Cancer, 7th edition.


Stage I Hypopharyngeal Carcinoma AJCC v6

Stage I includes: T1, N0, M0.  T1: Tumor limited to one subsite of the hypopharynx and 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.)


Refractory Thyroid Gland Oncocytic Carcinoma

Thyroid gland oncocytic carcinoma that is resistant to treatment.


Stage II Differentiated Thyroid Gland Carcinoma AJCC v7

Stage II includes: Under 45 years: Any T, Any N, M1.  45 years and older: T2, N0, M0.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  N0: No regional lymph node metastasis.  M1: Distant metastasis.  M0: No evidence of distant metastasis.  (from AJCC 7th Ed.)


Oropharyngeal (p16-Negative) Carcinoma by AJCC v8 Stage

A term that refers to the staging of p16-negative oropharyngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


Thyroid Gland Sclerosing Mucoepidermoid Carcinoma with Eosinophilia

A rare type of mucoepidermoid carcinoma of the thyroid gland, usually associated with chronic lymphocytic thyroiditis.  It exhibits a unique morphologic appearance consisting of a squamoid, nested growth pattern, dense fibrosis, and mucinous differentiation.  The histogenesis of this unusual carcinoma has been debated, and it is unclear if it arises from remnants of the ultimobranchial body or from the follicular epithelial cells.


Stage I Thyroid Gland Follicular Carcinoma AJCC v8

Stage I includes: Under 55 years: Any T, Any N, M0. 55 years and older: (T1, N0/NX, M0); (T2, N0/NX, M0).  T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. N0: No evidence of locoregional lymph node metastasis. NX: Regional lymph nodes cannot be assessed. M0: No distant metastasis. (from AJCC 8th Ed.)


Unresectable Laryngeal Squamous Cell Carcinoma

Laryngeal squamous cell carcinoma that is not amenable to surgical resection.


Metastatic Nasopharyngeal Nonkeratinizing Carcinoma

Nasopharyngeal nonkeratinizing carcinoma that has spread from its original site of growth to another anatomic site.


Metastatic Thyroid Gland Anaplastic Carcinoma

Thyroid gland anaplastic carcinoma that has spread from the original site of growth to another anatomic site.


Hypopharyngeal squamous cell carcinoma stage III

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor measuring more than 4 cm in greatest dimension or with fixation of hemilarynx or extension to esophagus.  T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or less in greatest dimension.  T2: Tumor invades more than one subsite of the hypopharynx or an adjacent site, or measures more than 2 cm but not more than 4 cm in greatest diameter without fixation of hemilarynx.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Spindle Cell Variant Thyroid Gland Papillary Carcinoma

Papillary carcinoma of the thyroid gland with focal areas of spindle cell metaplasia.


Locally Advanced Laryngeal Carcinoma

Laryngeal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Carcinoma of pyriform fossa

A carcinoma that arises from the pyriform sinus.  Patients usually present with advanced stage disease and the prognosis is poor.


Refractory Differentiated Thyroid Gland Carcinoma

Differentiated thyroid gland carcinoma that is resistant to treatment.


Stage I Laryngeal Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: (Supraglottis) Tumor limited to one subsite of supraglottis with normal vocal cord mobility. (Glottis) Tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility.  (Subglottis) Tumor limited to the subglottis.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Laryngeal Cancer by AJCC v8 Stage

A term that refers to the staging of laryngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Stage I includes: (T0, N0, M0); (T0, N1, M0); (T1, N0, M0); (T1, N1, M0); (T2, N0, M0); (T2, N1, M0). T0: No primary identified. T1: Tumor 2 cm or smaller in greatest dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Tumor with metastasis in four or fewer lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8

Stage IVB includes: T4b, Any N, M0. T4b: Very advanced disease; tumor of any size with extension towards the spine or into nearby large blood vessels, invading the prevertebral fascia, or encasing the carotid artery or mediastinal vessels. M0: No distant metastasis. (from AJCC 8th Ed.)


Stage IVC Laryngeal Verrucous Carcinoma AJCC v7

Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)