Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Delusional disorder, jealous type

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A subtype of delusional disorder characterized by the central delusional theme that the individual's spouse or lover is unfaithful.


Gastroesophageal Junction Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Grade 3 Esophageal Pain, CTCAE

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Severe pain; limiting self care ADL


Grade 1 Local Complication of Device and Prosthesis, CTCAE


Childhood Astrocytoma

An astrocytoma that occurs during childhood.


Advanced Large Cell Neuroendocrine Carcinoma

Large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Typhlitis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 1 Papulopustular Rash, CTCAE

Papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness


Grade 1 Anorectal Infection, CTCAE

Localized, local intervention indicated


Stage 0 Low Grade Appendix Mucinous Neoplasm (LAMN) AJCC v8

Stage 0 includes: Tis(LAMN), N0, M0. Tis(LAMN): Low-grade appendiceal mucinous neoplasm confined by the muscularis propria. Acellular mucin or mucinous epithelium may invade into the muscularis propria. T1 and T2 are not applicable to LAMN. Acellular mucin or mucinous epithelium that extends into the subserosa or serosa should be classified as T3 or T4a, respectively. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Hodgkin's disease nodular sclerosis recurrent

The reemergence of nodular sclerosis classic Hodgkin lymphoma after a period of remission.


Grade 4 Esophageal Obstruction, CTCAE

Life-threatening consequences; urgent intervention indicated


Metastatic Bladder Urachal Urothelial Carcinoma

Bladder urachal urothelial carcinoma that has spread to another anatomic site.


Stage IIIC Prostate Cancer AJCC v8

Stage IIIC includes: Any T, N0, M0, PSA: Any, Grade Group 5. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 5: Gleason Score 9 or 10, Gleason Pattern 4+5, or 5+4, or 5+5. (AJCC 8th ed.)


Grade 3 Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


Cramping Pain

A sense of discomfort or distress that is spasmodic or clenching.


Night Blindness, CTCAE

A disorder characterized by an inability to see clearly in dim light.


Grade 5 Other Renal or Genitourinary, CTCAE


Hepatitis C Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis C virus exposure and injury of the liver parenchyma.


Grade 3 Mucositis Oral, CTCAE

Severe pain; interfering with oral intake


Recurrent Childhood Large Cell Lymphoma

The reemergence of childhood large cell lymphoma after a period of remission.


Grade 2 Cyanosis, CTCAE

Present


Grade 3 Liver Dysfunction or Failure by Clinical Classification, CTCAE


Stage III Uterine Corpus Cancer

Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1-T3, N1/N2, M0); IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). T3b: Tumor involves vagina (direct extension or metastasis) or parametrial tissue. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Grade 2 Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Anal Fistula, CTCAE

Invasive intervention indicated


Infantile Myofibroma

A benign, localized, nodular and well-circumscribed neoplasm seen as a congenital neoplasm or in the first year of life. It is characterized by a biphasic growth pattern and is composed of small, undifferentiated mesenchymal cells associated with branching thin-walled vessels and more mature neoplastic spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma.


Radiologic Finding

Imaging results obtained through a radiology procedure.


Grade 1 Injury To Superior Vena Cava, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Vulvar Large Cell Neuroendocrine Carcinoma

A high grade neuroendocrine carcinoma that arises from the vulva. It is characterized by the presence of malignant large cells.


Grade 3 Neonatal Sinus Bradycardia, AE

An adverse event in a newborn characterized by persistent sinus bradycardia; resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention).


Grade 3 Pharyngeal Fistula, CTCAE

Invasive intervention indicated


Grade 2 Non-Myocardial Visceral Arterial Ischemia, CTCAE


Grade 2 Heart Intra-Operative Injury, CTCAE


Grade 4 Vascular Disorders - Other, Specify, CTCAE


Obstructed labor

A physical barrier to the natural delivery of a baby.


Grade 3 Bronchopulmonary Hemorrhage NOS, CTCAE


BAP1-Inactivated Melanocytoma

A cutaneous melanocytoma with inactivation of BAP1, highly atypical large epithelioid cells, and marked pleomorphism.


Recurrent Malignant Female Reproductive System Neoplasm

The reemergence of a malignant female reproductive system neoplasm after a period of remission.


Grade 2 Hypophosphatemia, CTCAE

Oral replacement therapy indicated


Bilateral Carcinoma

A carcinoma that affects both sides of an organ in a simultaneous or non-simultaneous manner.


Stage IVA Bone Cancer AJCC v8

Stage IVA includes: Any T, N0, M1a, Any G. N0: No regional lymph node metastasis. M1a: Metastasis in the lung. (AJCC 8th ed.)


Grade 4 Urinary Tract Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Neonatal Coagulation Disorder, AE

A coagulation disorder adverse event in a newborn characterized by life threatening consequences (e.g. severe pulmonary embolism, limb ischemia, hemorrhagic shock, disseminated intravascular coagulation (DIC)); requiring urgent major care changes.


Grade 4 Cataract, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Fibrinogen Decreased, CTCAE

A finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen.


Lower Extremity Artery Intra-Operative Injury, CTCAE


Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Squamous cell carcinoma, small cell, nonkeratinizing

A squamous cell carcinoma composed of small atypical cells, without morphologic evidence of keratin production.


Adipose Tissue Atrophy

Shrinking of adipose tissue.


Grade 5 Depressed Level of Consciousness, CTCAE

Death


Grade 5 Myocardial Infarction, CTCAE

Death


Grade 2 Gastrointestinal Pain, CTCAE

Moderate pain; limiting instrumental ADL


Unresectable Biliary Tract Carcinoma

Biliary tract carcinoma that is not amenable to surgical resection.


Prostate Cystadenoma

A rare cystadenoma affecting the prostate gland. It is characterized by the presence of multilocular prostatic cysts.


Metastatic glioma

Glioma that has spread from its original site of growth to another anatomic site.


Poor Prognosis Metastatic Gestational Trophoblastic Tumor

Metastatic gestational trophoblastic tumor in which risk factors are present.


Hodgkin Lymphoma During Pregnancy

Hodgkin lymphoma that occurs during pregnancy.


Vaginal Adenocarcinoma of Skene Gland Origin

A rare vaginal adenocarcinoma arising from the Skene gland. It is characterized by morphological and immunohistochemical features similar to prostate adenocarcinoma.


Thoracic meningomyelocele

A congenital abnormality in the thoracic region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Adenocarcinoma of the prostate stage IV

Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


Central Nervous System Hamartoma

A hamartoma that occurs in the central nervous system.


Grade 3 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Dialysis Catheter Obstruction

Blockage of a dialysis catheter by a thrombus or other substance.


Advanced Malignant Solid Neoplasm

A malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Dermatitis caused by substance taken internally

Dermatitis caused by an allergic reaction to an unspecified ingested substance.


Advanced Fibrosarcoma

Fibrosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Bladder Stricture or Stenosis, CTCAE


Necrotic tumor

A neoplasm characterized by focal or diffuse tumor cell necrosis.


Cutaneous Erdheim-Chester Disease

Erdheim-Chester disease that affects the skin.


Grade 5 Jejunal Hemorrhage, CTCAE

Death


Grade 3 Pharyngeal Mucositis, CTCAE

Severe pain; unable to adequately aliment or hydrate orally; limiting self care ADL


Grade 4 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IIIC Fallopian Tube Cancer AJCC v7

Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0).  T3c: Peritoneal metastasis outside the pelvis and more than 2 cm in diameter.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Congenital Varicella Zoster Infection

An infection, characterized by the rash of chickenpox or shingles, that is caused by the varicella-zoster virus transmitted directly from the mother to the fetus or neonate during late pregnancy or childbirth.


Grade 3 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Plasmacytic Hyperplasia Post-Transplant Lymphoproliferative Disorder

An early post-transplant lymphoproliferative lesion characterized by plasmacytic proliferation and architectural preservation of the involved tissues.  It often regresses either spontaneously or after reduction in immunosuppression.  The immunoglobulin genes are not rearranged.  In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion.


Grade 2 Pulmonary Hypertension, CTCAE

Moderate dyspnea, cough; requiring evaluation by cardiac catheterization and medical intervention


Hodgkin's disease nodular sclerosis stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 1 Oral Dysesthesia, CTCAE

Mild discomfort; not interfering with oral intake


Grade 4 Reproductive System and Breast Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Retroperitoneal abscess

An abscess that is located in the abdominal cavity posterior to the peritoneum.


Infusion Related Reaction, CTCAE

A disorder characterized by adverse reaction to the infusion of pharmacological or biological substances.


Grade 3 Gingiva Intra-Operative Injury, CTCAE


Grade 3 Otitis Media, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Cheilitis, CTCAE

Severe symptoms; limiting self care ADL; intervention indicated


Grade 1 Uterine Fistula, CTCAE

Asymptomatic


Dental and Teeth and Peridontal Pain, CTCAE


Confusion, Post-Ictal

A period of confusion following a seizure in which the patient does not respond appropriately despite appearing awake.


Hemorrhoidal Hemorrhage, CTCAE

A disorder characterized by bleeding from the hemorrhoids.


Grade 4 Lingual Nerve Intra-Operative Injury, CTCAE


Unresectable Transitional Cell Carcinoma

A transitional cell carcinoma which is not amenable to surgical resection.


Grade 2 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Irregular Menstruation, CTCAE

A disorder characterized by a change in cycle or duration of menses from baseline.


Grade 1 Gynecomastia, CTCAE

Asymptomatic


Congenital Intrahepatic Biliary Atresia

A congenital disorder characterized by blockage or absence of the intrahepatic bile ducts.


Grade 3 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Cytomegalovirus Infection

A cytomegalovirus infection that has recurred after a period of remission.


Grade 2 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Lymphedema-Related Fibrosis, CTCAE


Grade 4 Intestinal Stoma Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Pulmonary Fibrosis, CTCAE

Severe hypoxia; evidence of right-sided heart failure; radiographic pulmonary fibrosis >50-75%


Grade 4 Supraventricular Arrhythmia NOS, CTCAE


Grade 2 Sinus Pain, CTCAE

Moderate pain; limiting instrumental ADL


Unresectable Angiosarcoma

An angiosarcoma that is not amenable to surgical resection.


Reactive Epithelial Hyperplasia of the Ciliary Body

An increase in cell number and volume of the ciliary epithelium, usually in response to injury. (WHO 2018)


Grade 5 Cecum or Appendix Hemorrhage, CTCAE


Lacrimal Drainage System Adenocarcinoma

An adenocarcinoma that arises from the lacrimal sac or nasolacrimal duct.


Grade 5 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Refractory Epithelioid Malignant Peripheral Nerve Sheath Tumor

An epithelioid malignant peripheral nerve sheath tumor that does not respond to treatment.


Grade 3 Rash Maculo-Papular, CTCAE

Macules/papules covering >30% BSA with moderate or severe symptoms; limiting self care ADL


Lacrimal Drainage System Inverted Papilloma

A benign neoplasm of the lacrimal drainage system characterized by an inverted/endophytic or mixed growth pattern. It is the most common epithelial neoplasm of the lacrimal drainage system. (WHO 2018)


Grade 4 Laryngitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Hyperglycemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance.


No Cardiac Valve Regurgitation

No evidence of any retrograde blood flow through the valve(s) in the heart. (ACC)


A hepatocellular adenoma caused by activating mutations of beta-catenin.  It is characterized by the presence of nuclear atypia and absence of inflammation or steatosis.  There is an increased risk of malignant transformation.


Grade 3 Periventricular Leukomalacia, AE

An adverse event in a newborn characterized by periventricular echodensities, evolving in to extensive cystic periventricular lesions; or densities extending in to the deep white matter.


Grade 3 Treatment Related Secondary Malignancy, CTCAE

Non life-threatening secondary malignancy


Ancylostomiasis due to Ancylostoma duodenale

Ancylostomiasis that is caused by infection by Ancylostoma Duodenale.


Grade 3 Nystagmus, CTCAE

Severe symptoms; limiting self care ADL


Grade 3 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Childhood Hodgkin Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Grade 3 Mitral Valve Disease, CTCAE

Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention


Esophageal Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures).


Grade 2 Aortic Valve Disease, CTCAE

Asymptomatic; moderate regurgitation or stenosis by imaging


Grade 5 Sinus Disorder, CTCAE

Death


Grade 4 Depressed Level of Consciousness, CTCAE

Life-threatening consequences; coma; urgent intervention indicated


Grade 1 Non-Malignant Pericardial Effusion, CTCAE


Grade 5 Colonic Hemorrhage, CTCAE

Death


Virilization, CTCAE

A disorder characterized by inappropriate masculinization occurring in a female or prepubertal male.


Grade 5 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Psychosis Including Hallucinations and Delusions, CTCAE


Grade 4 Fever, CTCAE

>40.0 degrees C (>104.0 degrees F) for >24 hrs


Grade 3 Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Grade 1 Edema of the Head and Neck, CTCAE


Acute Myeloid Leukemia with RAM Immunophenotype

A high risk pediatric acute myeloid leukemia with an extremely poor prognosis. The blasts show bright CD56 expression, dim-to-negative expression of CD45 and CD38, and lack of HLA-DR expression. This immunophenotype was named after one of the pediatric patient's initials (RAM), from Children's Oncology Group (COG) clinical trial AAML0531.


Grade 4 Cranial Nerve IV Neuropathy, CTCAE


Vaginal Endometrioid Adenocarcinoma

A rare adenocarcinoma that arises from the vagina with histologic features resembling the endometrioid adenocarcinoma of the endometrium.


Late Disseminated Lyme Disease

A late stage of Lyme disease that may present in untreated patients months to years after a tick bite manifested with intermittent bouts of arthralgia, arthritis and neurologic complaints.


Grade 4 Cardiac Ischemia or Infarction, CTCAE


Grade 4 Pulmonary Fibrosis, CTCAE

Life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing


Grade 5 Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


Cervical Squamous Cell Carcinoma, Not Otherwise Specified

Cervical squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


Chest Pain in Left Third Intercostal Space

The location of the chest pain is within the third intercostal space on the left side.


Stage IIB Prostate Cancer AJCC v7

Stage IIB includes: (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T2c: Tumor involves both lobes.  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Somnolence, CTCAE

A disorder characterized by characterized by excessive sleepiness and drowsiness.


Dialysis Catheter Infection

A local or systemic infection associated with the use of a dialysis catheter.


Grade 2 Cognitive Disturbance, CTCAE

Moderate cognitive disability; interfering with work/school/life performance but capable of independent living; specialized resources on part time basis indicated


Recurrent Pancreatic Ductal Adenocarcinoma

The reemergence of pancreatic ductal adenocarcinoma after a period of remission.


Vaginal Non-Neoplastic Disorder

A non-neoplastic disorder that affects the vagina. Representative examples include vaginal infection and vaginal fibroepithelial polyp.


Grade 4 Rectum Intra-Operative Injury, CTCAE


Grade 2 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Gastric Necrosis, CTCAE

Death


Grade 2 Chills, CTCAE

Moderate tremor of the entire body; narcotics indicated


Superficial spreading adenocarcinoma

An adenocarcinoma which has spread within the mucosa without further invasion of the underlying tissues.


Stage IV Pancreatic Neuroendocrine Tumor AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Biliary Intraepithelial Neoplasia

A neoplastic, non-invasive lesion that affects the biliary epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Colonic Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the colon.


Grade 2 Fat Atrophy, CTCAE

Covering 10-30% BSA and associated with erythema or tenderness; limiting instrumental ADL


Cyst of tonsil

A cystic structure in the tonsillar tissue.


Grade 1 Atrial Fibrillation, CTCAE

Asymptomatic, intervention not indicated


Verrucous carcinoma of the oral cavity stage II


Recurrent Anaplastic Ganglioglioma

The reemergence of anaplastic ganglioglioma after a period of remission.


Adrenoleukodystrophy, Neonatal

A rare metabolic disorder that affects neonates. It is characterized by damage of the white matter in the brain and degeneration of the adrenal glands. It manifests with hyperactivity, paralysis, muscular weakness, crossed eyes, hearing loss, seizures, and coma.


Grade 2 Vulva Intra-Operative Injury, CTCAE


Grade 5 Tracheal Stenosis, CTCAE

Death


Grade 4 Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


Inguinal Mass

An abnormal growth in the groin.


Pancreatic Intraductal Tubulopapillary Neoplasm

An epithelial neoplasm that arises from the exocrine pancreas characterized by the formation of tubular structures, high grade dysplasia, and ductal differentiation. Grossly, it is characterized by the presence of intraductal nodular masses. Morphologically, there are nodules of tubular glands and occasional papillary structures growing in dilated ducts.  There is no significant mucin production. Signs and symptoms include epigastric pain, weight loss, vomiting, steatorrhea, and diabetes mellitus.


Grade 2 Bronchus Intra-Operative Injury, CTCAE


Cancer that is not dependent upon the presence of estrogen for metastasis or growth. 2005


Maternal Obesity

Obesity in a female who has a child.


Hirsutism, CTCAE

A disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen).


Grade 2 Throat and Pharynx and Larynx Pain, CTCAE


Atrophy of vagina

A condition characterized by the absence of squamous maturation in the vaginal epithelium. It is associated with decreased estrogen production.


Stage IIIA Cervical Cancer AJCC v8

Stage IIIA includes: T3a, Any N, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. M0: No distant metastasis. (AJCC 8th Ed.)


Genital Edema, CTCAE

A disorder characterized by swelling due to an excessive accumulation of fluid in the genitals.


Jugular Vein Intra-Operative Injury, CTCAE


Grade 2 Hypertrichosis, CTCAE

Increase in length, thickness or density of hair at least on the usual exposed areas of the body [face (not limited to beard/moustache area) plus/minus arms] that requires frequent shaving or use of destructive means of hair removal to camouflage; associated with psychosocial impact


Stage IB2 Cervical Cancer FIGO 2009

Cervical carcinoma measuring more than 5 mm in depth and more than 4 cm in maximum diameter. (FIGO 2009)


Grade 3 Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


Anal Mucositis

An inflammatory process affecting the mucous membrane of the anus.


Grade 5 Upper Airway Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Prolonged grief disorder

A psychiatric disorder characterized by the personal experience of intense and prolonged yearning for, or preoccupation with the circumstances surrounding, a loss that leads to significant impairment in social or occupational functioning. Associated symptoms may include: identity disruption, disbelief, avoidance of reminders, difficulty moving on, emotional pain or numbness, feeling that life is meaningless, and loneliness.


Delayed Orgasm, CTCAE

A disorder characterized by sexual dysfunction characterized by a delay in climax.


Grade 4 Glaucoma, CTCAE

Visual field deficit within the central 10 degrees of the visual field in the affected eye


Stage I Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

Stage I includes: T1, N0, M0. T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Recurrent Anaplastic Oligodendroglioma

The reemergence of anaplastic oligodendroglioma after a period of remission.


Musculoskeletal Chest Pain due to Sternal Injury

A condition in which there is musculoskeletal chest pain secondary to trauma to the sternum. (ACC/AHA)


Stage IV Skin Melanoma

A melanoma that arises from the skin and has metastasized to another anatomic site.


Recurrent Moderate-Severe Chronic Graft Versus Host Disease

The reemergence of moderate-severe chronic graft versus host disease after a period of remission.


Decreased Peak Drug Blood Concentration

Decreased maximum (peak) concentration of a drug observed after its administration.


Locally Advanced Bone Sarcoma

Bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Factor X Inactivation

Presence of inactivating antibodies to factor X in the blood.


Grade 3 Disseminated Intravascular Coagulation, CTCAE

Laboratory findings and bleeding


Grade 3 Small Intestinal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 1 Radiation Excluding Chemoradiation, CTCAE


Grade 1 Alkaline Phosphatase Increased, CTCAE

>ULN-2.5 x ULN if baseline was normal; 2.0-2.5 x baseline if baseline was abnormal


Megaureter

Enlargement of the diameter of the ureter, which can be partial or complete.


Euphoria, CTCAE 5.0

A disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli.


Refractory Malignant Peripheral Nerve Sheath Tumor

Malignant peripheral nerve sheath tumor that is resistant to treatment.


Precordial Catch Syndrome

A condition in which there is musculoskeletal chest pain characterized by brief, sharp discomfort associated with inspiration. (ACC/AHA)


Seminoma, anaplastic

A seminoma of the testis characterized by increased cellular pleomorphism, high mitotic activity, and a non-prominent stromal lymphocytic infiltrate.


Grade 2 Telangiectasia, CTCAE

Telangiectasias covering >=10% BSA; associated with psychosocial impact


Cranial Nerve XI Intra-Operative Injury, CTCAE


Grade 3 Adrenal Insufficiency, CTCAE

Severe symptoms; hospitalization indicated


Grade 2 Serum Glutamic Pyruvic Transaminase, CTCAE


NK-lymphoblastic leukemia/lymphoma

A precursor lymphoid neoplasm that expresses CD56 and immature T-cell markers, lacks B-lymphoid and myeloid markers, and has immunoglobulin and T-cell receptor genes in the germline configuration.


Grade 4 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cervical Cancer by AJCC v6 Stage

A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 6th edition.


Borderline Ovarian Serous Surface Papillary Tumor

A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of papillary proliferations that contain atypical serous epithelial cells in the outer surface of the ovary.  There is no evidence of stromal invasion.


Grade 2 Fallopian Tube Perforation, CTCAE

Invasive intervention not indicated


Male Non-Neoplastic Reproductive System Disorder

A non-neoplastic disorder that affects the male reproductive system. Representative examples include prostatitis, balanitis, and phimosis.


Localized Muscle Invasive Bladder Urothelial Carcinoma

A bladder urothelial carcinoma that has focally invaded into the bladder muscularis propria.


Intestinal Stoma Leak, CTCAE

A finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body).


Antepartum Obstetric Thromboembolism

Presence of a blood clot in the maternal vascular system which originated from a distant site during the antepartum period.


Grade 4 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


Squamous intraepithelial neoplasia grade 2


A hepatocellular carcinoma that arises in a patient with a history of organ transplantation.


Grade 3 Penile Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Vascular Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 4 Myelitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Good Prognosis Metastatic Gestational Trophoblastic Tumor

Metastatic gestational trophoblastic tumor in which risk factors are absent.


Urothelial carcinoma urethra recurrent

The reemergence of transitional cell carcinoma in the urethra after a period of remission.


Satellite Nodule

Additional, separate neoplastic nodules surrounding a central neoplastic lesion.


Stage 0 Testicular Cancer AJCC v8

Stage 0 includes: pTis, N0, M0, S0. pTis: Testicular cancer with a finding of germ cell neoplasia in situ. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


Large Intestinal Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine.


Grade 4 Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Cranial Nerve VII Neuropathy, CTCAE


Grade 5 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cervical meningomyelocele

A congenital abnormality in the cervical region of the spine in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Refractory Monomorphic Post-Transplant Lymphoproliferative Disorder

A monomorphic post-transplant lymphoproliferative disorder that does not respond to treatment.


Grade 1 Urine Discoloration, CTCAE

Present


Pancreatic Endocrine Glucose Intolerance, CTCAE


Grade 3 Hypocalcemia, CTCAE

Corrected serum calcium of <7.0-6.0 mg/dL; <1.75-1.5 mmol/L; Ionized calcium <0.9-0.8 mmol/L; hospitalization indicated


Serum Immunoglobulin Free Light Chain Ratio Abnormal

A laboratory test result indicating an abnormal kappa to lambda ratio of immunoglobulin free light chains in the serum.


Grade 4 Thrombotic Microangiopathy, CTCAE


Grade 5 Cranial Nerve I Neuropathy, CTCAE


Stage IIA Pancreatic Cancer AJCC v6 and v7

Stage IIA includes: T3, N0, M0.  T3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 5 Adrenal Insufficiency, CTCAE

Death


Grade 2 Peripheral Nerve Infection, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Grade 3 Neonatal Bradyarrhythmia, AE

A bradyarrhythmia adverse event in a newborn resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention).


Grade 3 Neonatal Hypotension, AE

An adverse event in a newborn characterized by persistent hypotension affecting perfusion; requiring major care change (e.g. vaso-active drugs or hydrocortisone).


Intoxication

Disturbances in psychophysiological functions and responses as a result of administration or ingestion of a psychoactive substance.


Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage III includes: IIIA: (T0-2, N1, M0); IIIB: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Burn, CTCAE

Medical intervention; minimal debridement indicated


Grade 1 Perineal Pain, CTCAE

Mild pain


Non-Neoplastic Hepatobiliary Disorder

A non-neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples include hepatitis, cirrhosis, cholangitis, and cholecystitis.


Locally Advanced Digestive System Neuroendocrine Tumor G2

Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to nearby tissues or lymph nodes.


Hypophosphatemia, CTCAE

A disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood.


Induced cataract

A cataract that has been produced artificially or by induction, e.g. as a result of device use, medication, trauma, tears, falls, accidental injury, etc.


Stage IA Vulvar Cancer AJCC v7

Stage IA includes: T1a, N0, M0. T1a: Tumor confined to the vulva and perineum, 2 cm or less in greatest dimension, and with stromal invasion no greater than 1 mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 5 CNS Necrosis and Cystic Progression, CTCAE


Recurrent Digestive System Neuroendocrine Tumor G1

The reemergence of digestive system neuroendocrine tumor G1 after a period of remission.


Atrioventricular Block First Degree, CTCAE

A disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds.


Grade 2 Pleuritic Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 5 Bone Marrow Hypocellular, CTCAE

Death


Grade 3 Fetal Growth Retardation, CTCAE

<5% percentile of weight for gestational age


Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8

Stage IIB includes: T2, N0, M0. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Esophageal Neuroendocrine Tumor G1

A rare, well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The majority of cases have a polypoid appearance, are small lesions, and found incidentally.


Grade 3 Intraoperative Breast Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 4 Bronchopulmonary Hemorrhage NOS, CTCAE


Grade 4 Urethral Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Mediastinum Intra-Operative Injury, CTCAE


Transcription Factor-Associated Monogenic Diabetes

Monogenic diabetes caused by inactivating mutation(s) in transcription factors regulating expression of pancreatic beta cell genes.


Grade 3 Flashing Lights and Floaters in Vision, CTCAE


Vaginal intraepithelial neoplasia grade 2

Vaginal intraepithelial neoplasia characterized by the presence of nuclear intraepithelial neoplastic changes in the lower two-thirds of the epithelium and parakeratosis.


Respirable Crystalline Silica Exposure

Environmental, occupational or consumer-based exposure to respirable particles derived from industrial processing or breakdown of silica-containing materials such as sand, concrete, stone, mortar, bricks,  glass, pottery and ceramics.


Anemia due to Increased Destruction

Anemia that results from an increased rate of erythrocyte destruction.


Grade 4 Fetal Growth Retardation, CTCAE

<1% percentile of weight for gestational age


Grade 4 Adrenal Gland Intra-Operative Injury, CTCAE


Grade 2 Serum Amylase Increased, CTCAE

>1.5-2.0 x ULN; >2.0-5.0 x ULN and asymptomatic


Grade 3 Neonatal Sinus Tachycardia, AE

An adverse event in a newborn characterized by persistent sinus tachycardia; resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention).


Skin squamous cell carcinoma recurrent

The reemergence of squamous cell carcinoma of the skin after a period of remission.


Grade 2 Rectal Varices Hemorrhage, CTCAE


Recurrent Childhood Pilomyxoid Astrocytoma

The reemergence of pilomyxoid astrocytoma in childhood after a period of remission.


Grade 3 Esophageal Necrosis, CTCAE

Inability to aliment adequately by GI tract; invasive intervention indicated


Grade 1 Hyperparathyroidism, CTCAE

Mild symptoms; intervention not indicated


Grade 4 Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Testicular Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Stage IVA Cervical Cancer FIGO 2009

Cervical carcinoma with rectal or bladder involvement. (FIGO 2009)


Grade 5 Methemoglobinemia, CTCAE

Death


Human Papillomavirus-Related Malignant Neoplasm

A malignant neoplasm associated with the presence of human papillomavirus infection.


Grade 2 Amenorrhea, CTCAE

Present


Metaplastic carcinoma

A general term used to describe carcinomas arising from epithelial cells that have been transformed into another cells type (metaplastic epithelial cells). A representative example is the adenocarcinoma arising in Barrett esophagus. This term is also used to describe carcinomas in which the malignant epithelial cells show differentiation towards another cell type. A representative example of the latter is the metaplastic breast carcinoma in which the malignant glandular cells show squamous, spindle cell, or chondroid/osseous differentiation.


Foveolar-Type Adenoma

A rare neoplastic polyp that arises from the stomach.  It is characterized by the presence of foveolar-type epithelium.  It may be seen in patients with familial adenomatous polyposis.


Grade 4 Portal Hypertension, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Avascular joint necrosis

Death of bone tissue in a joint due to temporary or permanent interruption of blood flow.


Endogenous Infection

An infection caused by an infectious agent that is present on or in the host prior to the start of the infection.


Grade 3 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Unresectable Malignant Mesothelioma

Malignant mesothelioma that is not amenable to surgical resection.


Grade 5 Intraoperative Hemorrhage, CTCAE

Death


Small Cell Adenocarcinoma

An adenocarcinoma composed of small malignant cells.


Grade 3 Productive Cough, CTCAE

Persistent or copious production of sputum; limiting self care ADL


Classic Type Trichilemmoma

A benign epithelial tumor arising from the outer root sheath of hair follicles.


Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


Pulmonary Edema, CTCAE

A disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure.


Grade 1 Gait Disturbance, CTCAE

Mild change in gait (e.g., wide-based, limping or hobbling)


Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


Non-Congenital Amegakaryocytosis

An acquired non-neoplastic disorder characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Imperforate Vagina

A congenital birth defect characterized by the absence of a normal vaginal opening.


Grade 1 Brachial Plexus Intra-Operative Injury, CTCAE


Grade 3 Cranial Nerve X Neuropathy, CTCAE


Hoarseness, CTCAE

A disorder characterized by harsh and raspy voice arising from or spreading to the larynx.


Stage IIIC Uterine Corpus Cancer AJCC v7

Stage IIIC includes: IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  Endocervical glandular involvement only should be considered as Stage I and not as Stage II. T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Puncture wound

Disruption of tissue caused by a pointed object.


Grade 4 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Central Nervous System Erdheim-Chester Disease

Rare involvement of the central nervous system by Erdheim-Chester disease.


Grade 1 Glossopharyngeal Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Recurrent Laryngeal Nerve Injuries

Damage to the recurrent laryngeal nerve.


Pancreatic Duct Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the pancreatic duct.


Hepatobiliary Disorders - Other, Specify, CTCAE


Stage IVA Vulvar Cancer AJCC v7

Stage IVA includes: (T1/T2, N3, M0); (T3, Any N, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.  N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage I Appendix Carcinoma AJCC v8

Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Kidney Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Skin Hypopigmentation, CTCAE

Hypopigmentation or depigmentation covering >10% BSA; associated psychosocial impact


Grade 1 Glomerular Filtration Rate, CTCAE


Malignant Vipoma

An aggressive neuroendocrine tumor located in the pancreas or small intestine. It is composed of cells containing vasoactive intestinal peptide.  It is associated with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria. It displays vascular invasion and metastasizes to other anatomic sites.


Squamoid Eccrine Ductal Carcinoma

A variant of ductal eccrine carcinoma with squamoid metaplasia.


Diffuse Pediatric-Type High Grade Glioma RTK1

An aggressive, WHO grade 4 diffuse glioma usually affecting children, adolescents, or young adults. It is characterized by receptor tyrosine kinase type 1 (RTK1) alterations.


Grade 2 Laryngeal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 3 Aspiration, CTCAE

Dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally


Grade 5 Postoperative Hemorrhage, CTCAE

Death


Stenosis of Gastrointestinal Stoma, CTCAE

A finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body).


Grade 3 Genital Edema, CTCAE

Lymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL


Grade 5 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

Death


Refractory Primary Myelofibrosis

Primary myelofibrosis that is resistant to treatment.


Cecum Ulcer, CTCAE

Cecum Ulcer that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


Congenital absence of uterus

A congenital abnormality characterized by the complete absence of the uterus.


Vaso-Occlusive Crisis in Sickle Cell-Hemoglobin C Disease

Sickle cell-hemoglobin C disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.


Refractory Digestive System Carcinoma

A carcinoma hat arises from any part of the digestive system and is resistant to treatment.


Grade 4 Diarrhea, CTCAE

Life-threatening consequences; urgent intervention indicated


Myeloid Neoplasms with Germline RUNX1 Mutation

An autosomal dominant syndrome characterized by abnormalities in platelet number and function and enhanced risk of developing myelodysplastic syndrome/acute myeloid leukemia at a young age. Patients have germline monoallelic mutations in RUNX1 gene. The clinical presentation is variable, even within the same family. Most affected individuals have a mild to moderate bleeding tendency. Platelet counts are normal or mildly reduced, with normal platelet morphology and variable degrees of platelet dysfunction. Distinct families with germline RUNX1 mutations exhibit varying risks of development of myeloid neoplasms with 11-100% (median: 44%) of family members affected. (WHO 2017)


Pancreatobiliary-type carcinoma

An invasive adenocarcinoma that arises from the ampulla of Vater. It is characterized by the presence of malignant cells that resemble the malignant cells of the pancreatic ductal or extrahepatic bile duct carcinomas.


Parietal cell carcinoma

An adenocarcinoma of the stomach arising from the parietal cells. It is characterized by the presence of malignant cells with eosinophilic, finely granular cytoplasm.


Grade 5 Hypokalemia, CTCAE

Death


Ischemic Change

Cellular damage due to diminished oxygen supply to the tissues. The changes may be mild and associated with chronic inflammation, or severe and associated with ulceration, necrosis, and hemorrhage.


Grade 5 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Duodenal Obstruction, CTCAE

Symptomatic; altered GI function


Excessive Bruising

Bruising that is disproportionately high to the amount of trauma received or reported.


Grade 5 Leukocytosis, CTCAE

Death


Grade 3 Device Related Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IV includes: IVA: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Refractory Childhood Central Nervous System Neoplasm

A central nervous system neoplasm in childhood that is resistant to treatment.


Bile Duct Mucinous Cystic Neoplasm, High Grade

A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of severe atypia.


Grade 1 Dizziness, CTCAE

Mild unsteadiness or sensation of movement


Grade 3 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


hepatoid adenocarcinoma of gallbladder

A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate that resembles hepatocellular carcinoma.


Salivary Duct Inflammation, CTCAE

A disorder characterized by inflammation of the salivary duct.


Elevated bilirubin levels in the blood of a newborn infant. It is a normal response due to the limited ability to excrete bilirubin until the maturation of the neonatal liver is complete.


Grade 2 Other Metabolic and Laboratory, CTCAE


Grade 2 Ligament Intra-Operative Injury, CTCAE


Abnormal Blood Protein

One or more of the blood protein levels being higher or lower than normal (e.g. Albumin, C-reactive Protein).


Grade 4 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Clinical Stage II Esophageal Adenocarcinoma AJCC v8

Stage II includes: IIA: T1, N1, M0; IIB: T2, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Ventilation or Perfusion Signs and Symptoms


Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Gastrointestinal Stoma Leak, CTCAE


Grade 2 Small Intestine Ulcer, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Grade 3 Lower Gastrointestinal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 3 Pneumonitis and Pulmonary Infiltrates, CTCAE


Neuroendocrine Carcinoma of Unknown Primary

A neuroendocrine carcinoma that has metastasized from an  unknown primary site.


Preinvasive Neoplasm of the Ampullary Region

A premalignant neoplastic and dysplastic lesion that arises from the ampulla of Vater.  It is characterized by the absence of invasion.  This category includes intestinal-type adenomas, noninvasive papillary neoplasms of pancreatobiliary type, and flat intraepithelial neoplasia.


Anal Canal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IA Esophageal Cancer AJCC v7

Stage IA includes: For squamous cell carcinoma: T1, N0, M0, G1, GX, Tumor location: Any. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  For adenocarcinoma: T1, N0, M0, G1-2, X. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated. GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Metastatic Digestive System Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from any part of the digestive system and has metastasized to another anatomic site.


Grade 2 Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Penile Pain, CTCAE

Severe pain; limiting self care ADL


undifferentiated carcinoma of appendix

A high grade carcinoma arising from the appendix, characterized by the absence of glandular or squamous differentiation.


Grade 5 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Aortic Valve Disease, CTCAE

Death


Grade 1 Cranial Nerve XI Neuropathy, CTCAE


Childhood Esophageal Carcinoma

A rare carcinoma of the esophagus that occurs during childhood.


Distal Urethral Carcinoma

A carcinoma that arises from the distal part of the urethra.


Grade 2 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

Death


Grade 3 Small Bowel NOS Intra-Operative Injury, CTCAE


Grade 1 Fever, CTCAE

38.0-39.0 degrees C (100.4-102.2 degrees F)


Grade 1 Pharyngeal Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Tuberculosis of adrenal glands

Tuberculosis of the adrenal gland.


Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 5 Ileus, CTCAE

Death


Grade 4 Right Ventricular Dysfunction, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., ventricular assist device); heart transplant indicated


Grade 4 Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Testicular Sex Cord-Gonadal Stromal Tumor, Mixed Forms

A sex cord-stromal tumor of the testis which may contain any combination of cell types, for example Sertoli cells, Leydig cells, and granulosa cells. Symptoms include testicular swelling and gynecomastia.


Lugano Classification Stage II Bulky Adult Lymphoma AJCC v8

Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Grade 2 CD4 Lymphocytes Decreased, CTCAE

<500-200/mm3; <0.5-0.2 x 10e9/L


Grade 5 Lower Extremity Artery Injury, CTCAE


Grade 5 Ileal Stenosis, CTCAE

Death


Grade 5 Enterovesical Fistula, CTCAE

Death


Digestive System Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant large cells.


Grade 3 Flu Like Symptoms, CTCAE

Severe symptoms; limiting self care ADL


Clinical Stage IV Cutaneous Melanoma AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Evidence of distant metastasis. (AJCC 8th ed.)


Grade 2 Muscle Weakness Left-Sided, CTCAE

Symptomatic; evident on physical exam; limiting instrumental ADL


Gastrointestinal Carcinoid Tumor

A well differentiated neuroendocrine neoplasm of low grade arising from the digestive system. It is composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with small vesicular nuclei. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The tumor can occur anywhere in the digestive system; approximately 90% arise in the appendix.


Grade 4 Chylous Ascites, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Refractory Esophageal Adenocarcinoma

Esophageal adenocarcinoma that is resistant to treatment.


Small Bowel Stricture or Stenosis NOS, CTCAE


Stage II Adult Diffuse Mixed Cell Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Neonatal Pneumothorax, AE

An adverse event in a newborn characterized by a collection of air or other gas between the visceral and parietal pleura.


Grade 3 Upper Airway Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Chemical Gastritis

Gastritis caused by injury to the gastric mucosa by chemicals. The injury occurs due to reflux of bile and pancreatic enzymes.


Upper Extremity Soft Tissue Necrosis, CTCAE


Grade 1 Ileus, CTCAE

Asymptomatic and radiologic observations only


Atrophic arthritis

An antiquated term indicating arthritis and bone loss.


Grade 5 Neonatal Sinus Tachycardia, AE

A sinus tachycardia adverse event in a newborn which results in death.


Grade 5 Small Bowel Obstruction NOS, CTCAE


Grade 2 Middle Ear Intra-Operative Injury, CTCAE


Grade 2 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 4 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Nasopharynx Intra-Operative Injury, CTCAE


Diffuse malignant lymphoma - centroblastic-centrocytic


Stage IIB Gastric Cancer AJCC v7

Stage IIB includes: (T4a, N0, M0); (T3, N1, M0); (T2, N2, M0); (T1, N3, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Supratentorial Ependymoma, YAP1-MAMLD1 Fusion-Positive

A supratentorial ependymoma characterized by a gene fusion involving YAP1 and MAMLD1 genes.


Grade 2 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Intraoperative Ocular Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 4 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Grade 4 Pancreas Intra-Operative Injury, CTCAE


Grade 1 Arachnoiditis, CTCAE

Mild symptoms


Grade 4 Small Intestinal Obstruction, CTCAE


Grade 5 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Anal Mucositis, CTCAE

Severe symptoms; limiting self care ADL


small cell carcinoma of appendix

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the wall of the appendix. It is characterized by the presence of malignant small cells.


Adverse Event Associated with the Musculoskeletal System and Soft Tissue


Acute and chronic inflammation

The coexistence of a chronic inflammatory process with a superimposed polymorphonuclear neutrophilic infiltration.


Grade 2 Neuroendocrine Gonadotropin Secretion Abnormality, CTCAE


Childhood Pre-B Acute Lymphoblastic Leukemia

Pre-B acute lymphoblastic leukemia that occurs during childhood.


Grade 4 Epistaxis, CTCAE

Life-threatening consequences; urgent intervention indicated


In situ follicular neoplasia

A follicular neoplasia confined to the germinal centers of the lymph nodes, without evidence of disseminated disease. It is characterized by the replacement of a germinal center by neoplastic centrocytes with uniformly intense positivity for BCL2. The surrounding mantle cuff and lymphoid architecture are intact. It has a low rate of progression to follicular lymphoma, but is often associated with prior or synchronous overt lymphoma.


Benign Familial Infantile Seizures

A genetically heterogenous afebrile seizure disorder of infancy, typically occurring between the third and eight month of life, that is characterized by brief partial seizures occurring in clusters over a day or several days. Psychomotor and neurologic development before and after seizures are normal.


Grade 4 Local Complication of Device and Prosthesis, CTCAE


Refractory Anal Canal Squamous Cell Carcinoma

Anal canal squamous cell carcinoma that is resistant to treatment.


Chronic candidiasis

Candidiasis that is persistent or long-standing in nature.


Grade 1 Retroperitoneum Hemorrhage, CTCAE


Clear cell adenocarcinoma of lung

A well differentiated morphologic variant of lung adenocarcinoma characterized by the predominance of clear cells.


Grade 1 Flushing, CTCAE

Asymptomatic; clinical or diagnostic observations only


Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Benign Germinative Follicular Epithelium Neoplasm

A benign neoplasm involving the germinative follicular epithelium.


Grade 3 Wrist Fracture, CTCAE

Limiting self care ADL; elective operative intervention indicated requiring hospitalization


Benign neoplasm of extrahepatic bile ducts

A non-metastasizing neoplasm that arises from the extrahepatic bile ducts.


Localized Gastroesophageal Junction Adenocarcinoma

An adenocarcinoma that arises from the gastroesophageal junction and has not spread to other anatomic sites.


Cervical Non-Neoplastic Disorder

A non-neoplastic disorder that affects the cervix. Representative examples include endometriosis and cervicitis.


Malignant Lymphoma, Non-Cleaved Cell Type


Stage II Vulvar Cancer AJCC v7

Stage II includes: T2, N0, M0.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Carcinoma Arising in Bladder Diverticulum

A carcinoma arising in a bladder diverticulum. Approximately one-third to half of the cases represent non-invasive, low-grade or high-grade urothelial carcinomas. Approximately half of the invasive carcinomas are urothelial. The rest include adenocarcinomas, squamous cell carcinomas, and small cell carcinomas.


Grade 2 Nail Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 3 Blood Bilirubin Increased, CTCAE

>3.0-10.0 x ULN if baseline was normal; >3.0-10.0 x baseline if baseline was abnormal


Grade 5 Gallbladder Infection, CTCAE

Death


Grade 5 Typhlitis, CTCAE

Death


Stage IV Low Grade Adult Non-Hodgkin's Lymphoma


Unresectable Osteosarcoma

An osteosarcoma which is not amenable to surgical resection.


Device Complication

Any problem arising from the use of a medical device.


Infusion Site Extravasation, CTCAE

A disorder characterized by leakage of the infusion into the surrounding tissue. Signs and symptoms may include induration, erythema, swelling, burning sensation and marked discomfort at the infusion site.


Grade 3 Purpura, CTCAE

Combined area of lesions covering >30% BSA; spontaneous bleeding


Decreased Concomitant Drug AUC

Decreased area under the plot of plasma concentration of a concomitant drug against time after its administration.


Giant cell and spindle cell carcinoma

A malignant epithelial neoplasm composed of giant, pleomorphic cells and spindle cells.


Neonatal Edema, AE

An adverse event in a newborn characterized by accumulation of an excessive amount of fluid in cells or intercellular tissues.


Grade 1 Oculomotor Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Hookworm Infections

An infection that is caused by hookworms.


Gallbladder Benign Non-Epithelial Neoplasm

A non-metastasizing neoplasm arising from the gallbladder wall.  The neoplastic process does not involve the epithelial layer. Representative examples include leiomyoma, lipoma, and neurofibroma.


Borderline Fallopian Tube Endometrioid Tumor

A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by the presence of glandular or cystic spaces which contain atypical glandular epithelial cells resembling endometrial cells.  There is no evidence of stromal invasion.


Grade 1 Anal Sphincter Intra-Operative Injury, CTCAE


Non-T Non-B CALLA Positive Adult Acute Lymphoblastic Leukemia

A non-T, non-B, acute lymphoblastic leukemia in which the lymphoblasts are positive for the common acute lymphoblastic leukemia antigen (CALLA) occurring in adults.


Pathologic Stage IIA Merkel Cell Carcinoma AJCC v8

Stage IIA includes: T2-3, N0, M0. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Grade 5 Colonic Ulcer, CTCAE

Death


Grade 4 Peritoneal Necrosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Non-Neoplastic Corneal Disorder

A non-neoplastic disorder that affects the cornea.


Hodgkin's disease mixed cellularity stage I site unspecified

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Grade 2 Folliculitis, CTCAE

Covering 10-30% of the body surface area; topical intervention initiated


Vulvar Warty Carcinoma

A squamous cell carcinoma that arises from the vulva and is characterized by the presence of a warty surface and cellular changes that are caused by human papillomavirus infection.


Appendix Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

A well differentiated neuroendocrine tumor arising from the wall of the appendix.  It is characterized by the presence of neoplastic cells forming round solid nests and occasionally glandular structures.  The majority of the cases are asymptomatic, and they are found incidentally in appendectomy specimens.  The majority of the tumors are located in the distal end of the appendix and they are enterochromaffin-cell carcinoid tumors producing serotonin.  Most cases show morphologic evidence of appendiceal wall and lymphatic vessel invasion by tumor cells.  Despite the morphologic evidence of invasion, appendiceal carcinoid tumors only infrequently produce lymph node or distant metastases.


Solid Neoplasm

A benign or malignant neoplasm arising from tissues that do not include fluid areas.  Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma).  Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors.


Grade 3 Large Intestinal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Laboratory Test Result

The outcome of a laboratory test.


Grade 3 Other Dermatology or Skin, CTCAE


Intimal dissection

A dissection of an artery that occurs though a tear in the inner lining of the blood vessel.


Grade 3 Laryngospasm, CTCAE

Recurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage)


Advanced Pancreatobiliary Carcinoma

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment.


Tissue Kallikrein Deficiency

A disorder characterized by the partial or complete absence of tissue-type kallikrein activity in the tissues and glandular secretions where it is normally present.


Grade 4 Uterine Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Stenosis of Gastrointestinal Stoma, CTCAE

Symptomatic; IV fluids indicated <24 hrs; manual dilation at bedside


Gallbladder Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the contents of the gallbladder.


Grade 5 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


Needle injury

A penetrating stab wound from a needle (or other sharp object) that may result in exposure to blood or other body fluids.


Urethra Obstruction, CTCAE

Blockage of the normal flow of urine in the urethra occurring following a procedure or pharmaceutical intervention.


Cutaneous Melanoma by AJCC v6 Stage

A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v6 classification system.


Alpha trait thalassemia

A condition in which a person has reduced protein production from two of the four alpha-globin alleles.


Fatigue, CTCAE 5.0

A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities.


Grade 2 Lower Extremity Artery Intra-Operative Injury, CTCAE


Glandular Cell Intraepithelial Neoplasia


Lymphedema, CTCAE

A disorder characterized by excessive fluid collection in tissues that causes swelling.


Virus-Related Lymphoma

Lymphoma that is caused by a virus infection.


Grade 2 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Intraoperative Respiratory Injury, CTCAE

Death


Grade 1 Watering Eyes, CTCAE

Intervention not indicated


Grade 5 Psychosis, CTCAE

Death


Throat and Pharynx and Larynx Pain, CTCAE


Atypical hyperplasia of breast

A general term that refers to atypical hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and columnar cell hyperplasia with atypia.


Grade 5 Rash Acneiform, CTCAE

Death


Grade 3 Spleen Intra-Operative Injury, CTCAE


Endocrine mucin-producing sweat gland carcinoma

A rare, low-grade sweat gland carcinoma with neuroendocrine differentiation. It usually arises on the eyelids and periorbital skin. It affects mostly older individuals. Women are affected more frequently than men. Morphologically, it is characterized by well-demarcated nodules with cystic, papillary, or cribriform architectural patterns. The neoplastic cells are small to intermediate polygonal to round cells. Small amounts of intracellular or extracellular mucin are present. In some cases, this carcinoma is a precursor of mucinous carcinoma.


Refractory Non-Cutaneous Melanoma

Non-cutaneous melanoma that is resistant to treatment.


benign fibrous histiocytoma of bone

A rare, benign neoplasm, usually arising from the non-metaphyseal regions of long bones or pelvis.  It is characterized by the presence of fibroblastic spindle cells arranged in a whorled storiform pattern, osteoclast-like giant cells, foam cells, inflammatory cells, hemosiderin deposition and stromal hemorrhage.


Grade 4 Small Intestine Infection, CTCAE


Musculoskeletal Chest Pain due to Intercostal Myofascial Injury

A condition in which there is musculoskeletal chest pain secondary to trauma to the connective tissues between the ribs. (ACC/AHA)


Adrenal Gland Intra-Operative Injury, CTCAE


Grade 4 Throat and Pharynx and Larynx Pain, CTCAE


Female sexual arousal disorder

A disorder characterized by a recurrent or persistent inability to attain or maintain until completion of sexual activity an adequate physical response of sexual excitement, consisting of vasocongestion in the pelvis, vaginal lubrication and expansion, and swelling of the external genitalia.


Grade 5 Biliary Tree Stricture or Stenosis, CTCAE


Grade 3 Ventricular Arrhythmia NOS, CTCAE


Spinal Injury Related to Birth

An injury to the spine sustained during the birthing process.


Grade 2 Central Nervous System Hemorrhage, CTCAE


Metastatic Meningioma

A meningioma that has spread from its original site of growth to another anatomic site.


Stage IVB Vaginal Cancer AJCC v6 and v7

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Spinal Cord Infarct During Birth

Ischemic necrosis of the spinal cord due to spinal artery occlusion during the birthing process.


Grade 3 Thrush, CTCAE

IV antifungal intervention indicated


Recurrent Childhood Gemistocytic Astrocytoma

The reemergence of gemistocytic astrocytoma in childhood after a period of remission.


Grade 3 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Endocrine Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Residual schizophrenia

A subtype of schizophrenia in which the individual has suffered an episode of schizophrenia but there are no longer any delusions, hallucinations, disorganized speech or behavior. Residual symptoms are seen in the form of negative symptoms (such as flat affect or avolition) or attenuated positive symptoms (such as odd beliefs).


Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Decreased Time To Concomitant Drug Peak Blood Concentration

Decreased time following concomitant drug administration at which the peak drug blood concentration occurs.


Panniculitis, Peritoneal

A disorder characterized by chronic inflammation and fibrosis of the adipose tissues in the peritoneal cavity.


Stage III Ampulla of Vater Cancer AJCC v7

Stage III includes: T4, Any N, M0. T4: Tumor invades peripancreatic soft tissues or other adjacent organs or structures other than the pancreas.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 3 Platelet Count Decreased, CTCAE

<50,000-25,000/mm3; <50.0-25.0 x 10e9/L


Oral Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips.


Chemical conjunctivitis

Inflammation of the conjunctiva in a newborn due to chemical irritation which was acquired postnatally from iatrogenic causes.


Pancreatic Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the pancreas. The Ki-67 index is higher than 20%.


Polygenic Obesity

Obesity associated with variations in multiple genes.


Grade 3 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Biliary Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Port Site Infection

An infection at an anatomic location used for vascular access.


Sunstroke

A reaction to prolonged exposure to high temperatures that can result in a failure of the body's temperature control system. It is often characterized by body temperature over 105 degrees, dehydration, headache, dizziness, nausea, vomiting, and muscle weakness.


Grade 2 Psychosis Including Hallucinations and Delusions, CTCAE


Acute Radiation Skin Toxicity

Erythema, desquamation, and other cutaneous injury resulting from, and occurring within days or weeks of, radiation exposure.


Stage III Appendix Neuroendocrine Tumor AJCC v7

Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor directly invades other adjacent organs or structures, e.g., abdominal wall and skeletal muscle.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Delusions, CTCAE

A disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense.


Nail Discoloration, CTCAE

A disorder characterized by a change in the color of the nail plate.


Chronic Myelomonocytic Leukemia-2

A chronic myelomonocytic leukemia characterized by the presence of 10-19 percent blasts in the bone marrow and 5-19 percent blasts in the peripheral blood or by the presence of Auer rods regardless of the blasts count.


Grade 3 Spermatic Cord Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 1 Partial Thromboplastin Time, CTCAE


Grade 4 Conjunctiva Intra-Operative Injury, CTCAE


Grade 5 Death NOS, CTCAE

Death


Grade 5 Pancreatic Anastomotic Leak, CTCAE

Death


Grade 4 Neonatal Diarrhea, AE

A diarrhea adverse event in a newborn characterized by life-threatening consequences (e.g. severe dehydration).


Birth Complication

The development of a problematic medical situation that occurs concurrently with the birth of a neonate.


Ann Arbor Stage II AIDS-Related Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 3 Thrombosis or Thrombus or Embolism, CTCAE


Grade 3 Bladder Intra-Operative Injury, CTCAE


Unresectable Neuroendocrine Neoplasm

A neuroendocrine neoplasm that is not amenable to surgical resection.


Grade 4 CD4 Lymphocytes Decreased, CTCAE

<50/mm3; <0.05 x 10e9/L


Dissociative Hysteria

A disorder characterized by sudden, unexpected travel away from one's home or place of work accompanied by an inability to recall one's past; the individual is confused about his or her personal identity and may assume a new identity.


Stage IIA Bone Cancer AJCC v8

Stage IIA includes: T1, N0, M0, G2 or G3. T1: Tumor measuring 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Proximal Gastric Adenocarcinoma

A gastric adenocarcinoma that arises from the proximal part of the stomach.


Grade 4 Abdomen NOS Intra-Operative Injury, CTCAE


Grade 4 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Bone Marrow Hypocellular, CTCAE

Moderately hypocellular or >25-<50% reduction from normal cellularity for age


Fallopian Tube Cancer by AJCC v6 Stage

A term that refers to the staging of fallopian tube carcinoma according to the American Joint Committee on Cancer, 6th edition.


Fistula of gallbladder

An abnormal communication between the gallbladder and another organ or cavity.


Aorticopulmonary Septal Defect

A congenital heart malformation characterised by incomplete separation of the truncus arteriosus and the aorticopulmonary trunk, resulting in communication between the aorta and pulmonary trunk.


Grade 3 Rectal Obstruction, CTCAE

Hospitalization indicated; invasive intervention indicated; limiting self care ADL


Grade 3 Bronchial Fistula, CTCAE

Invasive intervention indicated


Grade 2 Bronchospasm and Wheezing, CTCAE


Grade 2 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


FIGO Grade 3 Endometrial Mucinous Adenocarcinoma

A primary mucinous adenocarcinoma of the endometrium that contains more than 50% non-squamous solid areas.


Grade 1 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Grade 3 Chylous Ascites, CTCAE

Severe symptoms; elective operative intervention indicated


Grade 3 Partial Thromboplastin Time, CTCAE


Eruption cyst of jaw

A variant of dentigerous cyst found in the soft tissues overlying an erupting tooth. (WHO 2017)


Grade 2 Gastric Perforation, CTCAE

Invasive intervention not indicated


High Grade Gastric Intraepithelial Neoplasia

A gastric intraepithelial lesion characterized by the presence of neoplastic cells that are cuboidal with a high nucleus to cytoplasmic ratio, prominent nucleoli, significant architectural changes, and increased number of mitotic figures.


Intrahepatic Bile Duct Cancer by AJCC v8 Stage

A term that refers to the staging of intrahepatic bile duct cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to intrahepatic cholangiocarcinomas, combined hepatocellular-cholangiocarcinomas (mixed hepatocholangiocarcinomas), and primary neuroendocrine tumors of the liver. Primary sarcomas of the liver, pure hepatocellular carcinomas, hilar cholangiocarcinomas, and gallbladder carcinomas are not staged using this staging system. (from AJCC 8th Ed.)


Grade 5 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Retinopathy, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Localized Edema, CTCAE

A disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site.


Grade 3 Ovarian Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 5 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acral Edema

Accumulation of an excessive amount of watery fluid in cells or intercellular tissues of the hands and feet.


Early Inflammatory Arthritis

Early stages of inflammatory arthritis, when the underlying diagnosis is uncertain, usually little or no joint damage has occurred. Treatment may alter the disease course (e.g., potentially avert progression to full RA or other diagnosis).


Adult Acute Myeloid Leukemia with Minimal Differentiation

An acute myeloid leukemia with minimal differentiation occurring in adults.


Bladder granuloma

A granuloma that develops in the urinary bladder.


Adverse Event Attributed to Research

An indication that an adverse event is causally related to processes a subject was exposed to during a research study.


Non-Neoplastic Respiratory System Disorder

A non-neoplastic disorder that affects the respiratory system.  Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, tracheitis, and tracheal agenesis.


Grade 1 Lipohypertrophy, CTCAE

Asymptomatic and covering <10% BSA


Slipped Capital Femoral Epiphysis, CTCAE


Prostate Ductal Adenocarcinoma, Cribriform Pattern

A prostate ductal adenocarcinoma characterized by the presence of neoplastic large back-to-back glands with slit-like lumens.


Increased Drug Half Life

Increased period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.


Grade 3 Oral Intra-Operative Injury, CTCAE


Grade 5 Diarrhea, CTCAE

Death


Adult Pineocytoma

A pineocytoma occurring in adults.


Recurrent Neoplastic Post-Transplant Lymphoproliferative Disorder

The reemergence of neoplastic post-transplant lymphoproliferative disorder after a period of remission.


Grade 5 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Incised wound

A wound or cleft resulted from tissue separation into parts or laid open or penetrated with a sharp edge or instrument.


Grade 4 Gallbladder Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Hemorrhoids, CTCAE 5.0

A disorder characterized by the presence of dilated veins in the rectum and surrounding area.


Unresectable Fallopian Tube High Grade Serous Adenocarcinoma

Fallopian tube high-grade serous adenocarcinoma that is not amenable to surgical resection.


Laryngeal Edema, CTCAE

A disorder characterized by swelling due to an excessive accumulation of fluid in the larynx.


Grade 2 Slipped Capital Femoral Epiphysis, CTCAE


An epithelioid hemangioendothelioma that is not amenable to surgical resection.


Fallopian Tube Cancer by AJCC v8 Stage

A term that refers to the staging of fallopian tube cancer according to the American Joint Committee on Cancer, 8th edition.


Grade 5 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


Squamous cell carcinoma in situ with questionable stromal invasion

A malignant epithelial neoplasm involving all the layers of the squamous epithelium, but it is not certain if it is confined to the squamous epithelium or it has invaded the basement membrane and the underlying stroma.


Grade 1 Intraoperative Hepatobiliary Injury, CTCAE

Primary repair of injured organ/structure indicated


Grade 5 Hallucinations, CTCAE

Death


Adenocarcinoma with spindle cell metaplasia

An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to spindle-shaped cells.


Grade 3 Phrenic Nerve Dysfunction, CTCAE


Grade 3 Colitis, CTCAE

Severe abdominal pain; peritoneal signs


Bronchus Obstruction and Stenosis, CTCAE


Grade 5 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Periodontal Disease, CTCAE

Moderate gingival recession or gingivitis; multiple sites of bleeding on probing; moderate bone loss


Unresectable Cervical Carcinoma

Cervical carcinoma that is not amenable to surgical resection.


Grade 4 Endophthalmitis, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Grade 2 Somnolence and Depressed Level of Consciousness, CTCAE


Small Bowel Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Stage II Uterine Corpus Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Adverse Event Associated with Cardiac Arrhythmia


Cancer-related Cognitive Dysfunction

The effects of cancer and its treatments on cognitive processes.


Grade 5 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Gastrointestinal Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 4 Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


Prostate cancer stage D

Metastatic disease.


Polyp of esophagus

A benign intraluminal polypoid neoplasm of the esophagus.  It includes the squamous papilloma and the giant fibrovascular polyp.


Grade 4 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


caprolactams

A lactam in which the amide bond is contained within a seven-membered ring, which includes the amide nitrogen and the carbonyl carbon.


An  alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum.


Isoxazole

A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of  isoxazoles.


nutrient

A nutrient is a food component that an organism uses to survive and grow.


Oxazole

A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.


Dihydroconiferyl alcohol

A member of class of phenols that is 2-methoxyphenol substituted by a 3-hydroxypropyl group at position 4.


benzimidazole

A mancude organic heterobicyclic parent that is a heterocyclic organic compound comprising fused benzene and imidazole rings.


Benzoxazole

A benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5.


long-chain primary fatty alcohol

A long-chain fatty alcohol in which the hydroxy group is attached to a methylene (CH2) group.


(R)-cyclopentolate

The (R)-enantiomer of cyclopentolate.


(S)-cyclopentolate

The (S)-enantiomer of cyclopentolate.


Eckol

A phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity.


tetramine

Any polyamine that contains four amino groups.


nucleobase analogue

A molecule that can substitute for a normal nucleobase in nucleic acids.


alpha-L-fructofuranose

A L-fructofuranose with an alpha-configuration at the anomeric position.


beta-L-fructofuranose

A L-fructofuranose with a beta-configuration at the anomeric position.


L-fructofuranose

The L-enantiomer of fructofuranose.


beta-L-fructopyranose

A L-fructopyranose with a beta-configuration at the anomeric position.


L-fructopyranose

The L-enantiomer of fructopyranose.


L-cysteine thioether

Any L-cysteine derivative obtained by conversion of the thiol group into a sulfide.


Lactobiose

A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.


D-Glucose

A glucopyranose having D-configuration.


D-glucose

A glucose with D-configuration.


quinone

Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).


Menaquinone 10

Any member of the class of menaquinones that is 2-methyl-1,4-naphthoquinone with an unsaturated isoprenoid chain at the 3-position.


Vitamin K

Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.


A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.


hydroxyanthraquinones

An anthraquinone substituted with one or more hydroxy groups.


prenylquinone

A quinone substituted by a polyprenyl-derived side-chain. Prenylquinones occur in all living cells. Due to their amphiphilic character, they are mainly located in biological membranes where they function as electron and proton carriers in the photosynthetic and respiratory electron transport chains. Some prenylquinones also perform more specialised roles sucy as antioxidants and enzyme cofactors. Prenylquinones are classified according to ring structure: the main classes are menaquinones, phylloquinones, ubiquinones and plastoquinones.


Any member of the class of benzoquinones that is 1,4-benzoquinone or its C-substituted derivatives.


acenoquinone

Quinones containing an acene fused ring system.


Any benzoquinone derived from 2,3-dimethoxy-5-methylbenzoquinone; one of a group of naturally occurring homologues. The redox-active quinoid moiety usually carries a polyprenoid side chain at position 6, the number of isoprenoid units in which is species-specific. Ubiquinones are involved in the control of mitochondrial electron transport, and are also potent anti-oxidants.


menaquinones

Any prenylnaphthoquinone having a prenyl or polyprenyl group at position 3 and a methyl group at position 2 on the naphthoquinone ring.


An aminoglycoside antibiotic that is (1S,3S)-3,5,12-trihydroxy-3-(1-hydroxyethyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene having a 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl residue attached at position 1 via a glycosidic linkage.


prenylnaphthoquinone

Any napthoquinone that is substituted at position 2 by a prenyl or polyprenyl group. The term also includes compounds that are functionalised on the prenyl or polyprenyl chain (e.g. by a hydroxy group).


p-quinones

A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring.


A polycyclic aromatic ketone metabolite of naphthalene.


A naphthoquinone in which the oxo groups of the quinone moiety are at positions 1 and 4 of the parent naphthalene ring.


benzoquinones

Any quinone resulting from the formal oxidation of catechol, hydroquinone, or their C-substituted derivatives.


hydroxyquinone

Any quinone in which one or more of the carbons making up the quinone moiety is substituted by a hydroxy group.


N-acetylglucosamine

An N-acylglucosamine where the N-acyl group is specified as acetyl.


enol ether

Ethers ROR' where R has a double bond adjacent to the oxygen of the ether linkage.


(R)-Bifonazole

A 1-[biphenyl-4-yl(phenyl)methyl]imidazole that is the R-enantiomer of bifonazole.


A pyridinium ion obtained by protonation of the ring nitrogen of pyridoxal.


DL-Alanine

An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.


iodothyronine

An  iodoamino acid in which the amino acid specified is  thyronine.


organoiodine compound

An organoiodine compound is a compound containing at least one carbon-iodine bond.


iodoamino acid

An amino acid containing at least one iodo substituent.


benzyl alcohols

Compounds containing a phenylmethanol skeleton.


A 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol in which the carbon bearing the hydroxy group has S configuration while the remaining stereocentre has R configuration.


A 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol in which the carbon bearing the hydroxy group has R configuration while the remaining stereocentre has S configuration.


Ritodrina

A secondary amino compound that is 4-(2-amino-1-hydroxypropyl)phenol in which one of the hydrogens attached to the nitrogen is replaced by a 2-(4-hydroxyphenyl)ethyl group.


Ent-butopamine

A 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol in which both stereocentres have S configuration.


Dioxinodehydroeckol

A phlorotannin that is [1,4]benzodioxino[2,3-a]oxanthrene substituted by hydroxy groups at positions 1, 3, 6, 9 and 11. Isolated from the brown alga Ecklonia stolonifera, it exhibits radical scavenging activity.


hemiaminal

Any organic amino compound that has an amino group and a hydroxy group attached to the same carbon atom. Hemiaminals are intermediates in the formation of imines by addition of an amine to an aldehyde or ketone; those derived from primary amines are particularly unstable.


A member of the class of quinolones that is 1,2,3,4-tetrahydroquinoline in which the hydrogens at positions 2 and 4 have been replaced by oxo groups.


Any hydroxyflavanone with a hydroxy substituent at position 3' of the phenyl ring.


hydroxyflavanone

A member of the class of flavanones that consists of flavanone with one or more hydroxy substituents.


Any  oxo steroid carrying the oxo group at position 17.


(R)-Ketamine

The R- (less active) enantiomer of ketamine.


cyclopentanones

Any alicyclic ketone that consists of a cyclopentane skeleton substituted by at least one oxo group.


cyclohexenones

Any six-membered alicyclic ketone having one double bond in the ring.


Any oxo steroid where an oxo substituent is located at position 3.


Any methoxyflavanone having a methoxy substituent located at position 4'.


cyclohexanones

Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.


flavanones

Members of the class of flavans with a 3,4-dihydro-2-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives.


Any 3-oxo steroid that contains a double bond between positions 1 and 2.


alicyclic ketone

A cyclic ketone in which the carbocyclic ring structure which may be saturated or unsaturated, but may not be a benzenoid or other aromatic system.


methoxyflavanone

A member of the class of flavanones that consists of flavanone with one or more methoxy substituents.


A 3-oxo steroid that has alpha configuration at position 5.


Any 3-oxo steroid that has beta- configuration at position 5.


A 3-oxo-Delta(1) steroid containing an additional double bond between positions 4 and 5.


A 3-oxo steroid conjugated to a C=C double bond at the alpha,beta position.


monomethoxyflavanone

Any methoxyflavanone that is flavanone substituted by a methoxy group.


dihydroxyflavanone

Any  hydroxyflavanone carrying two hydroxy substituents.


A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.


A dicarboximide that is 3,4,5,6-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a p-bromophenyl group.


enamide

An alpha,beta-unsaturated carboxylic acid amide of general formula R(1)R(2)C=CR(3)-C(=O)NR(4)R(5) in which the amide C=O function is conjugated to a C=C double bond at the alpha,beta position.


cinnamamides

An enamide which is cinnamamide or a derivative of cinnamamide obtained by replacement of one or more of its hydrogens.


acrylamides

An enamide which is acrylamide or a derivative of acrylamide obtained by replacement of one or more of its hydrogens.


(-)-Nomifensine

The S enantiomer of nomifensine.


methylbenzene

Any alkylbenzene that is benzene substituted with one or more methyl groups.