Primary Choroidal Non-Hodgkin Lymphoma

An indolent, low-grade B-cell non-Hodgkin lymphoma that arises from the choroid. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Lymphoid follicles with germinal centers may be present. In the past these tumors were termed 'reactive lymphoid hyperplasia'. Now they are considered low-grade B-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

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The reemergence of T-cell/histiocyte-rich large B-cell lymphoma after a period of remission.


Stage I Adult Burkitt Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Secondary Central Nervous System Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


Intestinal T-Cell Lymphoma, Not Otherwise Specified

A T-cell lymphoma arising in the intestines, or sometimes other sites in the gastrointestinal tract, that does not conform to either classic enteropathy-associated T-cell lymphoma or monomorphic epitheliotropic intestinal T-cell lymphoma. (WHO 2017)


Ann Arbor Stage II Mature T- and NK-Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


Refractory Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

Diffuse large B-cell lymphoma associated with chronic inflammation that is resistant to treatment.


Marginal zone lymphoma refractory

Marginal zone lymphoma which does not respond to treatment.


Cerebral Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises in the cerebral hemispheres as a primary lesion.


Ann Arbor Stage II Contiguous Adult Non-Hodgkin Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


T-cell lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


primary cutaneous gamma-delta t-cell lymphoma

A primary cutaneous T-cell non-Hodgkin lymphoma that is characterised by the clonal cutaneous proliferation of activated mature gamma-delta T cells with a cytotoxic phenotype.


primary effusion lymphoma

Primary effusion lymphoma (PEL) is a large B-cell lymphoma located in the body cavities, characterized by pleural, peritoneal, and pericardial fluid lymphomatous effusions and that is always associated with human herpes virus-8 (HHV-8).


Adult Anaplastic Large Cell Lymphoma

An anaplastic large cell lymphoma occurring in adults.


Refractory Primary Effusion Lymphoma

Primary effusion lymphoma that is resistant to treatment.


Helicobacter Pylori-Related Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma that is caused by Helicobacter Pylori.


Refractory Grade 3 Follicular Lymphoma

Grade 3 follicular lymphoma that is resistant to treatment.


Early Unfavorable Non-Hodgkin Lymphoma

A clinical stage I or II non-Hodgkin lymphoma with at least one of the following risk factors: large mediastinal mass, extranodal spread, elevated erythrocyte sedimentation rate, involvement of at least three lymph node areas, and B symptoms.


Thyroid Non-Hodgkin's Lymphoma

A non-Hodgkin lymphoma primarily involving the thyroid gland.  The vast majority of cases are either diffuse large B-cell lymphomas or extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue. Hashimoto (chronic lymphocytic) thyroiditis is almost always present.


Grade 2 Cutaneous Follicular Lymphoma

A cutaneous lymphoma which contains 6-15 centroblasts per 40X high-power microscopic field.


Ann Arbor Stage III Grade 1 Follicular Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Fibrin-Associated Diffuse Large B-Cell Lymphoma

An unusual form of diffuse large B-cell lymphoma. It is not mass-forming and does not directly produce symptoms, but it is discovered incidentally on histological examination of surgical pathology specimens, excised for various pathologies other than lymphoma. The specimens typically contain fibrinous materials. Single and small aggregates of large lymphoma cells are found in only small foci within the fibrinous or amorphous material. EBV is positive, with type III latency. The clinical outcome is highly favorable, even with surgical excision alone. (WHO 2017)


Mycosis fungoides recurrent

The reemergence of mycosis fungoides after a period of remission.


Transformed B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

Histologic transformation of a B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma to an aggressive diffuse large B-cell lymphoma.


Anaplastic Large Cell Lymphoma, Sarcomatoid Subtype

A are variant of anaplastic large cell lymphoma. It is characterized by presence of large spindle shaped cells resembling a soft tissue sarcoma.


Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IIB includes: T3, N0-2, M0, B0,1. T3: One or more tumors (equal or greater than 1 cm in diameter). N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Childhood B Lymphoblastic Lymphoma

A B-lymphoblastic lymphoma that occurs during childhood.


Stage III Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage III includes: (T4, N0-2, M0, B0,1); IIIA (T4, N0-2, M0, B0); IIIB (T4, N0-2, M0, B1). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Primary mediastinal large B-cell lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Non-hodgkin lymphoma of colon

An extranodal non-Hodgkin lymphoma that arises from the colon.  The majority are B-cell non-Hodgkin lymphomas.


Ann Arbor Stage II Contiguous Adult Burkitt Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Angioimmunoblastic T-cell lymphoma recurrent

The reemergence of angioimmunoblastic T-cell lymphoma after a period of remission


Recurrent Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

The reemergence of primary vitreoretinal diffuse large B-cell lymphoma after a period of remission.


non-Hodgkin's lymphoma of small intestine

A B-cell or T-cell non-Hodgkin lymphoma that arises from the small intestine.  Representative examples of B-cell non-Hodgkin lymphoma include diffuse large B-cell lymphoma, MALT lymphoma, alpha heavy chain disease/immunoproliferative small intestinal disease, Burkitt lymphoma, follicular lymphoma, and mantle cell lymphoma.  The T-cell non-Hodgkin lymphomas are the enteropathy-associated T-cell lymphoma and the monomorphic CD56 positive intestinal T-cell lymphoma.


Childhood Grade III Lymphomatoid Granulomatosis

Grade III lymphomatoid granulomatosis that occurs during childhood.


Stage II Childhood Burkitt Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Primary Cutaneous Plasmablastic Lymphoma

Plasmablastic lymphoma that arises from the skin.


Primary Bone Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that arises from the bone, without lymph node or other extranodal involvement.


Refractory Mature B-Cell Non-Hodgkin Lymphoma

Mature B-cell non-Hodgkin lymphoma that does not respond to treatment.


Angiocentric lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Centroblastic Lymphoma by Ann Arbor Stage

An anatomic stage for centroblastic lymphoma based on the Ann Arbor classification criteria.


B Lymphoblastic Lymphoma

An uncommon type of lymphoma.  It constitutes approximately 10% of cases of lymphoblastic lymphoma.  Approximately 75% of cases reported in a literature review involved patients who were less than 18 years of age.  The most commonly affected sites are the skin, bone, soft tissue, and lymph nodes.  It has a high remission rate with a median survival of approximately 60 months.  (WHO, 2001)


Central Nervous System B-Cell Non-Hodgkin Lymphoma

A B-cell non-Hodgkin lymphoma that arises from the brain, meninges, or spinal cord.


Thymic Mucosa-Associated Lymphoid Tissue Lymphoma

A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that affects the thymus.  It is characterized by the presence of centrocyte-like or monocytoid lymphocytes that surround reactive lymphoid follicles.  There is infiltration of the thymic epithelium by lymphocytes and formation of lymphoepithelial lesions.  It is associated with the presence of autoimmune disease, most frequently Sjogren syndrome. Patients are usually asymptomatic and the tumor is detected incidentally as a mediastinal mass on chest x-ray.  A minority of patients present with dyspnea, hemoptysis, and chest pain.  The prognosis is excellent.


Conjunctival Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the conjunctiva.


Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

The reemergence of diffuse large B-cell lymphoma germinal center B-cell type after a period of remission.


Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Involving the Digestive System

An extranodal low-grade B-cell non-Hodgkin lymphoma arising in mucosal or glandular tissues of the digestive system. It recapitulates the cytoarchitectural features of mucosa-associated lymphoid tissue (MALT). It is composed of small lymphoid cells, often including marginal zone cells. (WHO 2019)


Precursor B-lymphoblastic lymphoma recurrent

The reemergence of B-lymphoblastic lymphoma after a period of remission.


Digestive System Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that arises from the digestive system.


Nodal Marginal Zone Lymphoma by Ann Arbor Stage

An anatomic stage for nodal marginal zone lymphoma based on the Ann Arbor classification criteria.


St. Jude Stage II Childhood Non-Hodgkin Lymphoma AJCC v8

Stage II: A single tumor (extranodal) with regional node involvement. Two or more nodal areas on the same side of the diaphragm. Two single (extranodal) tumors with or without regional node involvement on the same side of the diaphragm. A primary gastrointestinal tract tumor, usually in the ileocecal area, with or without involvement of associated mesenteric nodes only. (from AJCC 8th Ed.)


Marginal Zone Lymphoma by Ann Arbor Stage

An anatomic stage for marginal zone lymphoma based on the Ann Arbor classification criteria.


Mycosis fungoides/Sezary syndrome refractory

Mycosis fungoides and Sezary syndrome that is resistant to treatment.


AIDS-Related Burkitt Lymphoma with Plasmacytoid Differentiation

A Burkitt lymphoma with plasmacytoid differentiation occurring in HIV-positive patients.


Diffuse Blastoid B-Cell Lymphoma

A distinct subtype of high-grade follicular center cell lymphoma, representing a diffuse transformation of conventional follicular lymphoma.  Although this type of lymphoma strongly expresses BCL-2, it does not carry the characteristic t(14;18)(q32;q21) chromosomal translocation found in follicular lymphomas.  Instead, extra copies of chromosome 18 are often detected.


Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly is a rare form of diffuse large B-cell lymphoma occurring most commonly in patients over the age of 50 (usually between 70-75 years of age), without overt immunodeficiency, and presenting with nodal and extranodal involvement (in sites such as the stomach, lung, skin and pancreas) and B symptoms (fever, night sweats, weight loss). The tumor is characterized by an aggressive course and a short survival rate.


Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

The reemergence of primary cutaneous T-cell non-Hodgkin lymphoma after a period of remission.


mu-heavy chain disease

Mu-heavy chain disease (mu-HCD) is a type of HCD characterized by the production of incomplete monoclonal mu-heavy chains without associated light chains. The clinical presentation resembles that of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).


Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

Diffuse large B-cell lymphoma germinal center B-cell type that is resistant to treatment.


Intestinal T-cell lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Burkitt-like lymphoma with 11q aberration

A molecularly distinct B-cell lymphoma reminiscent of Burkitt lymphoma. It is characterized by the absence of MYC translocation and the presence of chromosome 11q aberrations.


Adult Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma occurring in adults.


Lymphohistiocytic Variant Anaplastic Large Cell Lymphoma

A histologic variant of anaplastic large cell lymphoma characterized by the presence of a large number of histiocytes admixed with the anaplastic lymphoma cells.


Thyroid Immunoblastic Lymphoma

A diffuse large B-cell lymphoma variant, primarily involving the thyroid gland.  It is composed predominantly of immunoblasts.


Recurrent Transformed T-cell Non-Hodgkin Lymphoma

The reemergence of T-cell non-Hodgkin lymphoma transformed after a period of remission.


Lymphoma, Large-Cell, Follicular

A follicular lymphoma which contains more than 15 centroblasts per 40X high-power microscopic field.


Adult T-cell lymphoma/leukemia refractory

Adult T-cell leukemia/lymphoma that is resistant to treatment.


Refractory High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements

High grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements that is resistant to treatment.


B-cell small lymphocytic lymphoma recurrent

The reemergence of small lymphocytic lymphoma after a period of remission.


Extracavitary Primary Effusion Lymphoma

A rare HHV8-positive B-cell lymphoma indistinguishable from primary effusion lymphoma presenting as solid tumor mass. (WHO 2017)


Stage II Indolent Adult Non-Hodgkin Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Stage IV Adult Immunoblastic Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Aggressive Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma with an aggressive clinical course.  Representative examples include Burkitt lymphoma, mantle cell lymphoma, and angioimmunoblastic T-cell lymphoma.


Parotid Gland Mucosa-Associated Lymphoid Tissue Lymphoma

A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue arising from the parotid gland. It is the most common type of non-Hodgkin lymphoma in the parotid gland and is often associated with Sjogren syndrome. The prognosis is favorable.


primary cutaneous marginal zone B-cell lymphoma

Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (malt) type as a result of an immunologically mediated disorder.


ST2 Diffuse Large B-Cell Lymphoma

A genetic subtype of diffuse large B-cell lymphoma characterized by SGK1 and TET2 gene mutations.


non-Hodgkin's lymphoma of salivary gland

A non-Hodgkin lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland. Mucosa-associated lymphoid tissue lymphoma is the most common primary salivary gland non-Hodgkin lymphoma.


Recurrent EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

The reemergence of EBV-positive diffuse large B-cell lymphoma, not otherwise specified after a period of remission.


Ann Arbor Stage II Grade 1 Non-Contiguous Follicular Lymphoma


Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IIA includes: T1-2, N1-2, M0, B0-1.  T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Non-Hodgkin's lymphoma refractory

A non-Hodgkin lymphoma which does not respond to treatment.


follicular lymphoma of lacrimal gland

A follicular lymphoma that arises from the lacrimal gland.


Stage IA Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IA includes: T1, N0, M0, B0-1.  T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Sinonasal Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the sinonasal tract.


AIDS-Related Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease

Diffuse large B-cell lymphoma arising in HHV8-positive multicentric Castleman disease occurring in HIV-positive patients.


follicular lymphoma of salivary gland

A follicular lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland.


Ann Arbor Stage II Adult Non-Contiguous Immunoblastic Lymphoma


Angiocentric lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Immunoblastic Lymphoma Post-Transplant Lymphoproliferative Disorder

An immunoblastic lymphoma that arises in a patient with a history of organ transplantation.


Lugano Classification Stage III Adult Non-Hodgkin Lymphoma AJCC v8

Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Recurrent Indolent T-Cell Non-Hodgkin Lymphoma

The reemergence of indolent T-cell non-Hodgkin lymphoma after a period of remission.


Stage III Anaplastic Large Cell Lymphoma

Ann Arbor Classification. Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Stage II Adult Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


Nodal marginal zone B-cell lymphoma refractory

Nodal marginal zone B-cell lymphoma resistant to treatment.


Primary EBV-Positive Nodal T-Cell or NK-Cell Lymphoma

An EBV-positive peripheral T-cell lymphoma that arises from the lymph nodes. It is characterized by a monomorphic pattern of infiltration and abscence of the angiodestruction and necrosis seen in extranodal NK/T-cell lymphomas. These lymphomas are more common in elderly patient, or in the setting of immune deficiency. For the time being, they are considered a variant of peripheral T-cell lymphoma, not otherwise specified. (WHO 2017)


Malignant lymphoma centroblastic, diffuse

A B-cell non-Hodgkin lymphoma composed of large noncleaved cells. This is a subtype of diffuse large B-cell non-Hodgkin lymphoma.


Recurrent Indolent B-Cell Non-Hodgkin Lymphoma

The reemergence of indolent B-cell non-Hodgkin lymphoma after a period of remission.


B-cell small lymphocytic lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

The reemergence of mature T-cell and NK-cell non-Hodgkin lymphoma after a period of remission.


Refractory Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma that resulted from the transformation of marginal zone lymphoma and is resistant to treatment.


Angioimmunoblastic T-cell lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Early Favorable Non-Hodgkin Lymphoma

A clinical stage I or II non-Hodgkin lymphoma without any of the following risk factors: large mediastinal mass, extranodal spread, elevated erythrocyte sedimentation rate, involvement of at least three lymph node areas, and B symptoms.


Mycosis fungoides stage II

Stage II includes: IIA (T1-2, N1-2, M0, B0-1); IIB (T3, N0-2, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Refractory Grade 2 Follicular Lymphoma

Grade 2 follicular lymphoma that is resistant to treatment.


Leukemic Phase of Non-Hodgkin's Lymphoma

A usually terminal event in the clinical course of lymphomas.  The term indicates the presence of atypical, clonal (malignant) lymphocytes (lymphoma cells) in the peripheral blood.


Refractory Aggressive Non-Hodgkin Lymphoma

An aggressive non-Hodgkin lymphoma that is resistant to treatment.


Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes

Molecular subtyping of diffuse large B-cell lymphomas (DLBCL) based on structural genomic abnormalities and gene expression data obtained from biopsy samples. The molecular analysis revealed four subtypes of DLBCL (MCD, BN2, N1, and EZB) which have distinct genotypic, epigenetic, and clinical characteristics. (NEJM 2018; 378: 1396-407)


Lugano Classification Limited Stage Adult Non-Hodgkin Lymphoma AJCC v8

Limited stage adult non-Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Adult T-cell lymphoma/leukemia stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Splenic Small Lymphocytic Lymphoma

Small lymphocytic lymphoma occurring in the spleen.


diffuse large B-cell lymphoma of the central nervous system

A diffuse large B-cell lymphoma arising from the central nervous system.


Follicular T-cell lymphoma

A lymph node-based peripheral T-cell lymphoma of T-follicular helper (TFH) cells, with a predominantly follicular growth pattern. It lacks characteristic features of angioimmunoblastic T-cell lymphoma such as proliferation of high endothelial venules or extrafollicular follicular dendritic cells. (WHO 2017)


Pharyngeal Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the pharynx.


Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other

A rare type of primary cutaneous diffuse large B-cell lymphoma that does not belong in the group of primary cutaneous diffuse large B-cell lymphomas, leg type, or the group of primary cutaneous follicle center lymphomas.  It includes subtypes/entities of diffuse large B-cell lymphoma (e.g. intravascular large B-cell lymphoma, plasmablastic lymphoma, T-cell/histiocyte rich lymphoma) that can involve the skin as the primary anatomic site.  Such cases, unlike their nodal counterparts, usually have an excellent prognosis.


Splenic Lymphoplasmacytic Lymphoma

A lymphoplasmacytic lymphoma  occurring in the spleen.


Refractory Breast Implant-Associated Anaplastic Large Cell Lymphoma

Breast implant-associated anaplastic large cell lymphoma that is resistant to treatment.


ALK-positive large B-cell lymphoma

Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma is a very rare variant of diffuse large B-cell lymphoma (DLBCL) mainly affecting middle-aged immunocompetent men and characterized by a consistent primary involvement of lymph nodes (mainly in the cervical and mediastinum lymph nodes) and with infrequent extra nodal involvement of the bone marrow and other extra-nodal sites (head and neck region, liver, spleen, and gastrointestinal tract). It has an aggressive disease course, and is associated with a poor prognosis.


non-Hodgkin's lymphoma of liver

A rare non-Hodgkin lymphoma that arises from the liver and the bulk of the tumor is located in the liver.  The most frequent types of non-Hodgkin lymphoma that arise from the liver are diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma.


Mantle cell lymphoma refractory

Mantle cell lymphoma resistant to treatment.


AIDS-Related Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that develops in a patient with AIDS.


Primary Mediastinal (Thymic) Large B-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for mediastinal (thymic) large B-cell lymphoma based on the Ann Arbor classification criteria.


Stage II Diffuse Large B-Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Adult Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma occurring in adults.


Lugano Classification Stage IE Adult Non-Hodgkin Lymphoma AJCC v8

Stage IE: Single extralymphatic site in the absence of nodal involvement. (from AJCC 8th Ed.)


peripheral T-cell lymphoma, not otherwise specified

Aggressive nodal or extranodal mature (peripheral) T-cell lymphomas that do not belong to the better defined entities of the remainder of mature T-cell lymphomas. This category includes the following variants: lymphoepithelioid cell variant (Lennert's lymphoma), follicular variant, and T-zone variant.


Recurrent Grade 1 Follicular Lymphoma

The reemergence of grade 1 follicular lymphoma after a period of remission.


Stage I Childhood Lymphoblastic Lymphoma

Stage I: A single tumor or nodal area is involved, excluding the abdomen and mediastinum (from PDQ).


Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IB includes: T2, N0, M0, B0-1. T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Anaplastic Large Cell Lymphoma, Signet Ring-Like Subtype

An anaplastic large cell lymphoma, characterized by lymphoid cells with signet ring nuclei.


Extranodal marginal zone B-cell lymphoma (MALT type) stage III

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage III disease.


Recurrent Central Nervous System Non-Hodgkin Lymphoma

The reemergence of central nervous system non-Hodgkin lymphoma after a period of remission.


ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) is a type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the expression of a protein called anaplastic lymphoma kinase (ALK).


Mycosis fungoides/Sezary syndrome recurrent

The reemergence of mycosis fungoides/Sezary syndrome after a period of remission.


Recurrent Adult Lymphoblastic Lymphoma

The reemergence of adult lymphoblastic lymphoma after a period of remission.


Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

Histologic transformation of an indolent B-cell non-Hodgkin lymphoma to an aggressive diffuse large B-cell lymphoma.


Adult Primary Cutaneous Anaplastic Large Cell Lymphoma

Primary cutaneous anaplastic large cell lymphoma that occurs in adults.


Aggressive T-Cell Non-Hodgkin Lymphoma

A T-cell non-Hodgkin lymphoma with an aggressive clinical course. This category includes T lymphoblastic lymphoma, anaplastic large cell lymphoma, ALK-negative, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, intestinal T-cell lymphoma, nasal type extranodal NK/T-cell lymphoma, peripheral T-cell lymphoma, not otherwise specified, and subtypes of primary cutaneous T-cell non-Hodgkin lymphoma.


Recurrent Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

The reemergence of primary systemic anaplastic large cell lymphoma, ALK-positive after a period of remission.


Recurrent Mature B-Cell Non-Hodgkin Lymphoma

The reemergence of mature B-cell non-Hodgkin lymphoma after a period of remission.


Lacrimal System Mucosa-Associated Lymphoid Tissue Lymphoma

A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal gland or the lacrimal drainage system.


Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Primary cutaneous diffuse large B-cell lymphoma, leg type that is resistant to treatment.


Grade 3 Cutaneous Follicular Lymphoma

A cutaneous lymphoma which contains more than 15 centroblasts per 40X high-power microscopic field.


Gastric Burkitt Lymphoma

An extranodal Burkitt lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


Ann Arbor Stage IV Grade 3 Follicular Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Recurrent Non-Hodgkin Lymphoma

The reemergence of non-Hodgkin lymphoma after a period of remission.


Small Lymphocytic Lymphoma by Ann Arbor Stage

An anatomic stage for small lymphocytic lymphoma based on the Ann Arbor classification criteria.


High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

A rare B-cell non-Hodgkin lymphoma that is characterized by the abnormal rearrangement of MYC gene, BCL2 gene, and/or BCL6 gene. Patients with this type of lymphoma usually respond poorly to standard treatments and have a poor prognosis.


Diffuse large B-cell lymphoma associated with chronic inflammation

A diffuse large B-cell lymphoma arising in body cavities or narrow spaces of long standing chronic inflammation.  The classic example is the pyothorax-associated lymphoma that arises in the pleural cavity of patients with a history of long standing pyothorax.


Primary mediastinal large B-cell lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


gastric diffuse large B-cell lymphoma

An extranodal diffuse large B-cell lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


Non-Hodgkin Lymphoma During Pregnancy

Non-Hodgkin lymphoma that occurs during pregnancy.


Recurrent Primary Effusion Lymphoma

The reemergence of primary effusion lymphoma after a period of remission.


Enteropathy-Associated T-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for enteropathy-associated T-cell lymphoma based on the Ann Arbor classification criteria.


Childhood Non-Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for childhood non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Tonsillar Mantle Cell Lymphoma

A rare mantle cell lymphoma that affects the tonsil and the bulk of the tumor is in this anatomic area.


Recurrent Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

The reemergence of monomorphic epitheliotropic intestinal T-cell lymphoma after a period of remission.


Small Intestinal Atypical Burkitt/Burkitt-Like Lymphoma

A morphologic variant of Burkitt lymphoma that arises from the small intestine.  It is characterized by marked nuclear pleomorphism, abundant apoptotic debris, and the presence of tangible body macrophages.


Refractory Grade 3a Follicular Lymphoma

Grade 3a follicular lymphoma that is resistant to treatment.


Transformed Non-Hodgkin Lymphoma

Histologic transformation of a usually indolent non-Hodgkin lymphoma to an aggressive non-Hodgkin lymphoma.


Prostate Follicular Lymphoma

A rare follicular lymphoma that arises from the prostate gland.


Burkitt's lymphoma of kidney

A rare Burkitt lymphoma arising from the kidney.


Large B-cell lymphoma arising in HHV8 associated multicentric Castleman disease

An aggressive diffuse large B-cell lymphoma occurring in patients with HHV8-positive multicentric Castleman disease. It is characterized by the presence of human herpesvirus 8-infected large B-lymphocytes that resemble plasmablasts. It is usually seen in patients with HIV infection.


Adult T-cell lymphoma/leukemia recurrent

The reemergence of adult T-cell leukemia/lymphoma after a period of remission


Small Lymphocytic Lymphoma with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

Small lymphocytic lymphoma characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.


Unfavorable Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma with unfavorable prognosis.


Nodal marginal zone B-cell lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Nodal marginal zone B-cell lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Recurrent Transformed B-Cell Non-Hodgkin Lymphoma

The reemergence of B-cell non-Hodgkin lymphoma transformed after a period of remission.


Primary Iris Non-Hodgkin Lymphoma

An extremely rare low-grade B-cell non-Hodgkin lymphoma that arises from the iris. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Most cases represent extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


follicular lymphoma of lung

An exceedingly rare follicular lymphoma that arises in and is confined to the lung at the time of diagnosis.


breast diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma that arises from the breast. It is the most common type of primary breast lymphoma.


Lymphoplasmacytic Lymphoma by Ann Arbor Stage

An anatomic stage for lymphoplasmacytic lymphoma based on the Ann Arbor classification criteria.


Refractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Primary diffuse large B-cell lymphoma of the central nervous system that does not respond to treatment.


Lacrimal Drainage System Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the lacrimal sac. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


indolent B-cell non-Hodgkin lymphoma

A B-cell non-Hodgkin lymphoma with an indolent clinical course. Representative examples include grade 1 and grade 2 follicular lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma.


Mycosis Fungoides by AJCC v7 Stage

A term that refers to the staging of mycosis fungoides, following the rules of the TNM AJCC v7 classification system.


Cardiac Fibrin-Associated Diffuse Large B-Cell Lymphoma

A rare fibrin-associated diffuse large B-cell lymphoma that affects the heart.


Recurrent Grade 3 Follicular Lymphoma

The reemergence of grade 3 follicular lymphoma after a period of remission.


Central Nervous System Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

A primary central nervous system non-Hodgkin lymphoma derived from mature or post-thymic T-cells or NK-cells.


Transformed Waldenstrom Macroglobulinemia to Diffuse Large B-Cell Lymphoma

Histologic transformation of Waldenstrom macroglobulinemia to an aggressive diffuse large B-cell lymphoma.


diffuse large B-cell lymphoma germinal center B-cell type

A diffuse large B-cell lymphoma that is characterized by the expression of CD10, BCL-6, A-myb, and LMO2 genes, BCL-2 translocation, and c-REL amplification.


Ann Arbor Stage I Mature T- and NK-Cell Lymphoma


Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue by Ann Arbor Stage

An anatomic stage for extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue based on the Ann Arbor classification criteria.


AIDS-Related Primary Effusion Lymphoma

Primary effusion lymphoma occurring in HIV-positive patients.


Conjunctival Follicular Lymphoma

A follicular lymphoma that arises from the conjunctiva.


Lymphoepithelioid lymphoma

A variant of peripheral T-cell lymphoma, not otherwise specified.  It is characterized by the presence of neoplastic small lymphocytes infiltrating the lymph nodes in a diffuse and less frequently interfollicular pattern.  There is an associated proliferation of epithelioid histiocytes forming confluent clusters.


Stage IV Childhood Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Lugano Classification Stage IIE Adult Non-Hodgkin Lymphoma AJCC v8

Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Sezary syndrome recurrent

The reemergence of Sezary syndrome after a period of remission.


Centroblastic lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


St. Jude Stage I Childhood Non-Hodgkin Lymphoma AJCC v8

Stage I: A single tumor (extranodal) or single anatomic area (nodal), with the exclusion of the mediastinum or abdomen. (from AJCC 8th Ed.)


Advanced Anaplastic Large Cell Lymphoma

Anaplastic large cell lymphoma that has spread extensively to distant anatomic sites.


Refractory Indolent B-Cell Non-Hodgkin Lymphoma

Indolent B-cell non-Hodgkin lymphoma that is resistant to treatment.


AIDS-Related Diffuse Large B-cell Lymphoma

A diffuse large B-cell lymphoma occurring in HIV-positive patients.


Primary mediastinal large B-cell lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Central Nervous System T-Cell Non-Hodgkin Lymphoma

A T-cell lymphoblastic lymphoma or a mature T-cell and NK-cell neoplasm that affects the brain, meninges, or spinal cord.


anaplastic large cell lymphoma of lung

A rare anaplastic large cell lymphoma that arises in the lung parenchyma.


Colorectal Mantle Cell Lymphoma

A mantle cell lymphoma that arises from the colon or rectum.  It often presents as a polypoid lesion.


Small Intestinal B-Cell Non-Hodgkin Lymphoma

A B-cell non-Hodgkin lymphoma that arises from the small intestine.  Representative examples include diffuse large B-cell lymphoma, mucosa-associated lymphoid tissue lymphoma, alpha heavy chain disease/immunoproliferative small intestinal disease, Burkitt lymphoma, follicular lymphoma, and mantle cell lymphoma.


Refractory Subcutaneous Panniculitis-Like T-Cell Lymphoma

Subcutaneous panniculitis-like T-cell lymphoma that is resistant to treatment.


Recurrent Aggressive Adult Non-Hodgkin Lymphoma

The reemergence of an aggressive adult non-Hodgkin lymphoma after a period of remission.


follicular lymphoma of thyroid gland

A rare follicular lymphoma primarily involving the thyroid gland.


B-cell small lymphocytic lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


primary cutaneous follicle center lymphoma

A primary lymphoma of the skin composed of various numbers of small and large irregular neoplastic follicle center cells. Its morphologic pattern can be nodular, diffuse, or nodular and diffuse. It presents with solitary or grouped plaques and tumors, and it usually involves the scalp, forehead, or trunk. It rarely involves the legs. This type of cutaneous lymphoma tends to remain localized to the skin.


Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma

A mucosa-associated lymphoid tissue lymphoma affecting the conjunctiva.


Indolent Adult Non-Hodgkin Lymphoma

An indolent non-Hodgkin lymphoma occurring in adults.  Representative examples include small lymphocytic lymphoma, lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia, marginal zone B-cell lymphoma, and grade 1 and 2 follicular lymphoma.


Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

Small lymphocytic lymphoma characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


splenic diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma occurring in the spleen.


Noncutaneous Anaplastic Large Cell Lymphoma by Ann Arbor Stage

An anatomic stage for noncutaneous anaplastic large cell lymphoma based on the Ann Arbor classification criteria.


Refractory Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

Primary systemic anaplastic large cell lymphoma, ALK-positive that is resistant to treatment.


Stage IIIA Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IIIA includes: T4, N0-2, M0, B0. T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). (AJCC 8th ed.)


Adult Non-Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for adult non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Adult B Lymphoblastic Lymphoma

B-lymphoblastic lymphoma that occurs in adults.


Nasal Type NK/T-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for nasal type NK/T-cell lymphoma based on the Ann Arbor classification criteria.


Primary Cutaneous T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

T-Cell/histiocyte-rich large B-cell lymphoma that arises from the skin.


Intestinal T-cell lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Stage I Childhood Burkitt Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Mediastinal T Lymphoblastic Lymphoma

A precursor T-lymphoblastic lymphoma that arises from the mediastinum.  It usually presents with an anterior mediastinal mass and respiratory distress.  It may present acutely with superior vena cava syndrome.  It usually affects adolescent and young adult males.  It is treated with aggressive chemotherapy and radiation.  The prognosis is better in the pediatric patients.


Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

A T-cell non-Hodgkin lymphoma that arises from the skin and does not respond to treatment.


Indolent Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma with an indolent clinical course.


St. Jude Stage III Childhood Non-Hodgkin Lymphoma AJCC v8

Stage III: Two single tumors (extranodal) on opposite sides of the diaphragm. Two or more nodal areas above and below the diaphragm. All the primary intrathoracic tumors (mediastinal, pleural, and thymic). All extensive primary intra-abdominal disease. All paraspinal or epidural tumors, regardless of other tumor site(s). (from AJCC 8th Ed.)


Ann Arbor Stage II Aggressive Adult Non-Hodgkin Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Double-Expressor Lymphoma

A diffuse large B-cell lymphoma characterized by double expression of MYC and BCL2 proteins without MYC and BCL2 gene aberrations. These lymphomas may have a worse prognosis than other diffuse large B-cell lymphomas, not otherwise specified, but they are not as aggressive as the high-grade B-cell lymphomas, with rearrangements of MYC and BCL2 and/or BCL6 genes.


Peripheral T-cell lymphoma unspecified refractory

Peripheral T-cell lymphoma, not otherwise specified that is resistant to treatment.


Recurrent Adult Non-Hodgkin Lymphoma

The reemergence of non-Hodgkin lymphoma in adults after a period of remission.


B-cell non-Hodgkin lymphoma

The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003


Adult T Lymphoblastic Lymphoma

T-lymphoblastic lymphoma occurring in adults.


primary cutaneous anaplastic large cell lymphoma

Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is a rare T-cell non-Hodgkin lymphoma that affects the skin and generally shows no extracutaneous involvement at presentation. It belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders along with lymphomatoid papulosis with which it shares overlapping clinical and histopathologic features.


African Burkitt's lymphoma

A clinical variant of Burkitt lymphoma that occurs in equatorial Africa.  The Epstein-Barr virus has been detected in all patients.  It is the most common malignancy of childhood in this area.


The reemergence of Waldenstrom macroglobulinemia after a period of remission.


T-cell/histiocyte rich large B cell lymphoma (THRLBCL) is a rare variant of diffuse large B-cell lymphoma (DLBCL), mainly affecting middle-aged men and often not being discovered until an advanced disease stage, with involvement of the spleen, liver and bone marrow occurring at a greater frequency than in DLBCL. It is often difficult to diagnose due to its similarity with other lymphoid diseases such as classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma and has an aggressive clinical course.


Ann Arbor Stage IIX (Bulky) Non-Hodgkin Lymphoma

Ann Arbor Stage II non-Hodgkin lymphoma with a mass of nodes with one diameter more than 10cm or a mediastinal mass larger than one third of the transthoracic width. (Cotswolds modification)


large-cell immunoblastic lymphoma

Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.


Refractory Aggressive T-Cell Non-Hodgkin Lymphoma

An aggressive T-cell non-Hodgkin lymphoma that is resistant to treatment.


Adult T-cell lymphoma/leukemia stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Recurrent Childhood Lymphoblastic Lymphoma

The reemergence of lymphoblastic lymphoma in childhood after a period of remission.


Grade 1 Diffuse Follicular Lymphoma

A follicular lymphoma with diffuse pattern characterized by the presence of 5 or less centroblasts per 40 high-power fields.


Burkitt-Like Lymphoma Post-Transplant Lymphoproliferative Disorder

A Burkitt-like lymphoma that arises in a patient with a history of organ transplantation.


Refractory Nodal Peripheral T-Cell Lymphoma with TFH Phenotype

Nodal peripheral T-cell lymphoma with TFH phenotype that is resistant to treatment.


high-grade B-cell lymphoma double-hit/triple-hit

A B-cell lymphoma that is characterized by the abnormal rearrangement of two genes, MYC gene and either BCL2 or BCL6 genes.


Stage I Adult Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type

The reemergence of diffuse large B-cell lymphoma activated B-cell type after a period of remission.


Splenic T Lymphoblastic Lymphoma

T-lymphoblastic lymphoma that affects the spleen.


Angioimmunoblastic T-cell lymphoma stage III


Small Intestinal Follicular Lymphoma

A follicular lymphoma that arises from the small intestine.  It most often affects the duodenum.


Breast T-Cell Non-Hodgkin Lymphoma

A T-cell non-Hodgkin lymphoma that arises from the breast as a primary tumor.  Primary T-cell non-Hodgkin lymphomas of the breast are rare.


Stage IB Mycosis Fungoides AJCC v7

Stage IB includes: T2, N0, M0, B0-1. T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Acute Adult T-Cell Leukemia/Lymphoma

The most common variant of adult T-cell leukemia/lymphoma.  It is characterized by systemic disease with a leukemic phase, generalized lymphadenopathy, and skin lesions.  Hypercalcemia is commonly seen.


Ann Arbor Stage II Adult Contiguous Immunoblastic Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Diffuse large B-cell lymphoma activated B-cell type that is resistant to treatment.


Angiocentric lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Lacrimal Drainage System Mucosa-Associated Lymphoid Tissue Lymphoma

A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal sac.


Non-Hodgkin Breast Lymphoma

A non-Hodgkin lymphoma that arises from the breast.  There is no history of extramammary breast non-Hodgkin lymphoma and ipsilateral axillary lymph node involvement does not exclude the diagnosis of primary breast non-Hodgkin lymphoma.  Most patients present with a painless breast lump.  The vast majority of cases are B-cell non-Hodgkin lymphomas.  Diffuse large B-cell lymphoma, follicular lymphoma, and extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue are the most common types of primary non-Hodgkin lymphoma of the breast.


Common Variant Anaplastic Large Cell Lymphoma

An anaplastic large cell lymphoma, characterized by CD30 positive lymphoid cells.


Mycosis fungoides/Sezary syndrome stage II

Stage II includes: IIA (T1-2, N1-2, M0, B0-1); IIB (T3, N0-2, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Diffusion Restriction

A radiologic finding seen as high-signal intensity on diffusion weighted imaging with corresponding reduced apparent diffusion coefficient (ADC) values. ADC is a measurement of the diffusion of water molecules in a given tissue.


Parotid Gland Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the parotid gland.  Representative examples include mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


Diffuse Large B-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for diffuse large B-cell lymphoma based on the Ann Arbor classification criteria.


Waldenstrom macroglobulinemia with serum IgM monoclonal protein equal or more than 3 g/dL and/or at least 10% bone marrow lymphoplasmacytic infiltration but no evidence of constitutional symptoms, symptomatic anemia, or hyperviscosity. (Blood 2008, 112:2709)


lymphoblastic lymphoma

A lymphoma composed of immature small to medium-sized precursor lymphoid cells (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma.


Recurrent High Grade B-Cell Lymphoma

The reemergence of high grade B-cell lymphoma after a period of remission.


BN2 diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma that is categorized as BN2 with high probability by the LymphGen algorithm. This is based on a combination of genetic features and BN2 DLBCLs often, but do not always, have a translocation involving the BCL6 locus and/or some combination of mutations affecting NOTCH2, TNFAIP3, BCL10 and UBE2A. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting CD70, which can be coding or non-coding.


Follicular Lymphoma by Ann Arbor Stage

An anatomic stage for follicular lymphoma based on the Ann Arbor classification criteria.


Stage III Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Extranodal marginal zone B-cell lymphoma (MALT type) stage II

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage II disease.


Extranodal marginal zone B-cell lymphoma (MALT type) refractory

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that is resistant to treatment.


EBV-Related Burkitt Lymphoma

Burkitt lymphoma that is caused by Epstein-Barr virus infection.


Refractory Transformed Non-Hodgkin Lymphoma

An indolent non-Hodgkin lymphoma which has undergone histologic transformation to an aggressive non-Hodgkin lymphoma and has become resistant to treatment.


Follicular lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Burkitt Lymphoma Post-Transplant Lymphoproliferative Disorder

A Burkitt lymphoma that arises in a patient with a history of organ transplantation.


Angioimmunoblastic T-cell lymphoma stage II


folliculotropic mycosis fungoides

Folliculotropic mycosis fungoides is a rare variant of mycosis fungoides (MF), a form of cutaneous T-cell lymphoma, and is characterized by the presence of folliculotropic infiltrates in patch-plaque lesions usually involving the head and neck area.


Refractory Plasmablastic Lymphoma

Plasmablastic lymphoma that is resistant to treatment.


Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

The reemergence of transformed follicular lymphoma to diffuse large B-cell lymphoma after a period of remission.


Nasopharyngeal Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the nasopharynx.


Ann Arbor Stage II Contiguous Adult Aggressive Non-Hodgkin Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


AIDS-Related Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

A diffuse large B-cell lymphoma that arises from the central nervous system in AIDS patients.


ALK-negative anaplastic large cell lymphoma (ALK- ALCL) is a type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the lack of expression of a protein called anaplastic lymphoma kinase (ALK).


Mature T- and NK-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for mature T- and NK-cell non-Hodgkin lymphomas based on the Ann Arbor classification criteria.


Mantle Cell Lymphoma by Ann Arbor Stage

An anatomic stage for mantle cell lymphoma based on the Ann Arbor classification criteria.


Angioimmunoblastic T-cell lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Primary Uveal Non-Hodgkin Lymphoma

An indolent, low-grade B-cell non-Hodgkin lymphoma that arises from the choroid, iris, or ciliary body. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Lymphoid follicles with germinal centers may be present. In the past these tumors were termed 'reactive lymphoid hyperplasia'. Now they are considered low-grade B-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


Stage III Indolent Adult Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Centroblastic lymphoma recurrent

The reemergence of centroblastic lymphoma after a period of remission.


Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IB includes: T2, N0, M0, B0,1. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Ann Arbor Stage IV Mature T- and NK-Cell Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Mycosis fungoides refractory

Mycosis fungoides resistant to treatment.


Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IIB includes: T3, N0-2, M0, B0-1.  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

A T-cell peripheral lymphoma affecting multiple anatomic sites. It is composed of usually large, pleomorphic, CD30 positive T-lymphocytes with abundant cytoplasm. It is characterized by the presence of a translocation involving the ALK gene and expression of ALK fusion protein.


Nodal Peripheral T-Cell Lymphoma of T Follicular Helper Cell Origin

A subset of node-based peripheral T-cell lymphomas with phenotypic features of T follicular helper (TFH) cells. This category includes angioimmunoblastic T-cell lymphomas, follicular T-cell lymphomas, and nodal peripheral T-cell lymphomas with T follicular helper phenotype.


Recurrent Nodal Peripheral T-Cell Lymphoma with TFH Phenotype

The reemergence of nodal peripheral T-cell lymphoma with TFH phenotype after a period of remission.


splenic mantle cell lymphoma

A mantle cell lymphoma occurring in the spleen.


Recurrent Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

The reemergence of diffuse large B-cell lymphoma that resulted from the transformation of marginal zone lymphoma, after a period of remission.


Recurrent Burkitt Lymphoma

The reemergence of Burkitt lymphoma after a period of remission.


Prostate Diffuse Large B-Cell Lymphoma

A rare diffuse large B-cell lymphoma that arises from the prostate gland.


Monomorphic epitheliotropic intestinal T-cell lymphoma

A mature T-cell and NK-cell non-Hodgkin lymphoma of intraepithelial T-lymphocytes. It usually arises from the small intestine. A minority of cases arise from the large intestine or the stomach. It is characterized by the presence of a monomorphic cellular infiltrate of small to medium-sized T-lymphocytes that are cytotoxic and express CD56. It is not associated with celiac disease.


large B-cell diffuse lymphoma of salivary gland

A diffuse large B-cell lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland.


Ann Arbor Stage II Grade 1 Follicular Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Childhood Anaplastic Large Cell Lymphoma

An anaplastic large cell lymphoma that occurs during childhood.


Anaplastic Lymphoma Post-Transplant Lymphoproliferative Disorder

An anaplastic lymphoma that arises in a patient with a history of organ transplantation.


Stage IV Indolent Adult Non-Hodgkin Lymphoma


enteropathy-associated T-cell lymphoma

An uncommon mature T-cell lymphoma of intraepithelial lymphocytes. It usually arises from the small intestine, most commonly the jejunum or ileum. Other less frequent primary anatomic sites include the duodenum, stomach, colon, or outside the gastrointestinal tract. It is seen with increased frequency in regions with a high prevalence of celiac disease.


Ann Arbor Stage III Grade 3 Follicular Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


T-cell lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


Refractory Primary Cutaneous Anaplastic Large Cell Lymphoma

Primary cutaneous anaplastic large cell lymphoma that is resistant to treatment.


Ann Arbor Stage II Grade 2 Contiguous Follicular Lymphoma


Sezary syndrome refractory

Sezary syndrome that is resistant to treatment.


follicular lymphoma of spleen

A follicular lymphoma occurring in the spleen.


Refractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

Transformed follicular lymphoma to diffuse large B-cell lymphoma that is resistant to treatment.


central nervous system anaplastic large cell lymphoma

An anaplastic large cell lymphoma that affects the brain, meninges, or spinal cord.


Ann Arbor Stage II Grade 1 Contiguous Follicular Lymphoma


Lacrimal Gland Mucosa-Associated Lymphoid Tissue Lymphoma

A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal gland.


Hodgkin-Like Adult T-Cell Leukemia/Lymphoma

'Hodgkin-like T-cell leukemia/lymphoma occurring in adults.


Angioimmunoblastic T-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for angioimmunoblastic T-cell lymphoma based on the Ann Arbor classification criteria.


Triple hit lymphoma

A rare B-cell non-Hodgkin lymphoma that is characterized by the abnormal rearrangement of MYC gene, BCL2 gene, and BCL6 gene. Patients with this type of lymphoma usually respond poorly to standard treatments and have a poor prognosis.


Waldenstrom macroglobulinemia that does not respond to treatment.


Ann Arbor Stage III Aggressive Adult Non-Hodgkin Lymphoma


Blastoid Variant Mantle Cell Lymphoma

An aggressive mantle cell lymphoma characterized by the presence of neoplastic B-lymphocytes resembling lymphoblasts.


thyroid gland diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma primarily involving the thyroid gland.


Ann Arbor Stage I Grade 2 Follicular Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Precursor B-lymphoblastic lymphoma stage III


localized pagetoid reticulosis

A variant of mycosis fungoides, characterized by an exclusively intraepidermal atypical (cerebriform) lymphocytic infiltrate. Patients present with a localized psoriasiform or hyperkeratotic patch or plaque, usually in the extremities. Extracutaneous dissemination of the disease has never been reported.


Refractory Systemic Anaplastic Large Cell Lymphoma

Systemic anaplastic large cell lymphoma that does not respond to treatment.


Primary Vitreoretinal Non-Hodgkin Lymphoma

An uncommon and potentially fatal intraocular non-Hodgkin lymphoma that involves the uvea, retina, vitreous body, and optic nerve. It is a subset of primary central nervous system non-Hodgkin lymphoma. The majority of cases are diffuse large B-cell lymphomas.


grade 3B follicular lymphoma

A grade 3 follicular lymphoma composed of solid sheets of centroblasts.


Recurrent Hepatosplenic T-Cell Lymphoma

The reemergence of hepatosplenic T-cell lymphoma after a period of remission.


Grade III Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis characterized by the presence of aggregates of neoplastic large B-lymphocytes, usually admixed with pleomorphic and Hodgkin-like cells, in a background of chronic inflammation.  Necrotic changes are present and are usually extensive.  Grade III lymphomatoid granulomatosis should be approached clinically as a subtype of diffuse large B-cell lymphoma.


Primary cutaneous acral CD8 positive T-cell lymphoma

A cutaneous T-cell lymphoma presenting as an acral (peripheral) lesion. It was originally described as originating in the ear and is usually localized to a single site. It is composed of CD8-positive neoplastic T-lymphocytes. It has an indolent clinical course.


Adult Systemic Anaplastic Large Cell Lymphoma

An anaplastic large cell lymphoma affecting multiple anatomic sites and occurring in adults.


Predominantly Diffuse Follicular Lymphoma with 1p36 Deletion

A predominantly diffuse, low-grade follicular lymphoma. It often presents as a large localized inguinal mass, lacks BCL2 rearrangement, and is associated with 1p36 deletion.


Colon Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that arises from the colon.  It is the most frequent type of lymphoma found in the colon.


Mycosis fungoides stage I

Stage I includes: IA (T1, N0, M0, B0-1); IB (T2, N0, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Stage III Childhood Anaplastic Large Cell Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Nodal marginal zone B-cell lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Childhood Immunoblastic Lymphoma

An immunoblastic lymphoma (a variant of diffuse large B-cell lymphoma) occurring in children.


Prostate Mantle Cell Lymphoma

A rare mantle cell lymphoma that arises from the prostate gland.


The reemergence of lymphoplasmacytic lymphoma after a period of remission.


Refractory Transformed T-cell Non-Hodgkin Lymphoma

An indolent T-cell non-Hodgkin lymphoma which has undergone histologic transformation to an aggressive T-cell non-Hodgkin lymphoma and has become resistant to treatment.


Non-Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for non-Hodgkin lymphomas based on the Ann Arbor classification criteria.


Stage IVB Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IVB includes: T1-4, N0-3, M1, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified).  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.  (AJCC 7th ed.)


Lymphoplasmacytoid lymphoma/immunocytoma stage III


Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

Mature T-cell and NK-cell non-Hodgkin Lymphoma that is resistant to treatment.


AIDS-Related Non-Hodgkin Lymphoma of the Cervix

A non-Hodgkin lymphoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


Liver Mucosa-Associated Lymphoid Tissue Lymphoma

A rare mucosa-associated lymphoid tissue lymphoma that arises from the liver.  It is characterized by the presence of centrocyte-like cells surrounding germinal centers.  Lymphoepithelial lesions involving the bile duct epithelium may also be present.


Mature B-Cell Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that originates from mature B lymphocytes. Representative examples include diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, and small lymphocytic lymphoma.


small cell variant anaplastic large cell lymphoma

A histologic variant of anaplastic large cell lymphoma characterized by the presence of a predominant population of small to medium size malignant cells with irregular nuclei.


Ann Arbor Stage II Non-Contiguous Mantle Cell Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Ann Arbor Stage I Aggressive Adult Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Anaplastic large cell lymphoma T- and null-cell types refractory

Anaplastic large cell lymphoma resistant to treatment.


Mediastinal Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma arising from the mediastinum.


Chlamydia Psittaci-Associated Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma

Mucosa-associated lymphoid tissue lymphoma that arises from the ocular adnexa and caused by stimulation of lymphoid tissue due to Chlamydia psittaci bacterial infection.


Colorectal Burkitt Lymphoma

A rare Burkitt lymphoma that arises from the colon or rectum.


Recurrent Systemic Anaplastic Large Cell Lymphoma

The reemergence of systemic anaplastic large cell lymphoma after a period of remission.


Primary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtype

A rare, mature T-Cell lymphoma arising from the skin.


Colon Mantle Cell Lymphoma

A mantle cell lymphoma that arises from the colon.  It often presents as a polypoid lesion.


Smoldering Adult T-Cell Leukemia/Lymphoma

An adult T-cell leukemia/lymphoma characterized by less than 5% neoplastic lymphocytes in the peripheral blood, absence of lymphadenopathy and hypercalcemia, and occasional skin or pulmonary lesions.


follicular malignant lymphoma of breast

A follicular lymphoma that arises from the breast as a primary tumor.


Charcot-Marie-Tooth disease X-linked recessive 3

X-linked Charcot-Marie-Tooth disease type 3 is a rare, genetic, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the childhood- to adolescent-onset of progressive, distal muscle weakness and atrophy (beginning in the lower extremities and then affecting the upper extremities), as well as distal, pansensory loss in the upper and lower extremities, pes cavus, and absent or reduced distal tendon reflexes. Pain and paresthesia are frequently the initial sensory symptoms. Spastic paraparesis (manifested by clasp-knife sign, hyperactive deep-tendon reflexes, and Babinski sign) has also been reported.


Charcot-Marie-Tooth disease type X

A subtype of Charcot-Marie-Tooth disease with genetic defects on the X chromosome.


Charcot-Marie-Tooth disease X-linked recessive 4

X-linked Charcot-Marie-Tooth disease type 4 is a rare, genetic, axonal, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the neonatal- to early childhood-onset of severe, slowly progressive, distal muscle weakness and atrophy (in particular of the peroneal group), as well as sensory impairment (with the lower extremities being more affected than the upper extremities), pes cavus, areflexia and hammertoes. Sensorineural hearing loss and cognitive impairment may also be associated. Females are asymptomatic and do not display the phenotype.


Charcot-Marie-Tooth disease X-linked recessive 5

X-linked Charcot-Marie-Tooth disease type 5 is a rare, genetic, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the infancy- to childhood-onset of: 1) progressive distal muscle weakness and atrophy (first appearing and more prominent in the lower extremities than the upper) which usually manifests with foot drop and gait disturbance, 2) bilateral, profound, prelingual sensorineural hearing loss and 3) progressive optic neuropathy. Females are asymptomatic and do not display the phenotype.


Charcot-Marie-Tooth disease X-linked dominant 1

Charcot-Marie-Tooth neuropathy that is inherited in an X-linked manner, and is associated with mutation(s) in the GJB1 gene, encoding gap junction beta-1 protein. The condition is characterized by moderate to severe motor and sensory neuropathy in males, and mild to no symptoms in females.


Charcot-Marie-Tooth disease X-linked recessive 2

X-linked Charcot-Marie-Tooth disease type 2 is a rare, genetic, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the infantile- to childhood-onset of progressive, distal muscle weakness and atrophy (more prominent in the lower extremities than in the upper extremities), pes cavus, and absent tendon reflexes. Sensory impairment and intellectual disability has been reported in some individuals.


Charcot-Marie-Tooth disease X-linked dominant 6

X-linked Charcot-Marie-Tooth disease type 6 is a rare, genetic, principally axonal, peripheral sensorimotor neuropathy characterized by an X-linked dominant inheritance pattern and the childhood-onset of slowly progressive, moderate to severe, distal muscle weakness and atrophy of the lower extremities, as well as distal, panmodal sensory abnormalities, bilateral foot deformities (pes cavus, clawed toes), absent ankle reflexes and gait abnormalities (steppage gait). Females are usually asymptomatic or only present mild manifestations (mild postural hand tremor, mild wasting of hand intrinsic muscles).


statin (semi-synthetic)

A statin that is derived from a naturally occurring statin by partial chemical synthesis.


hippocampal sclerosis of aging

Age-related neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus


Benign cyst of ovary

A non-malignant ovarian cyst.


corpus luteum cyst

A ovarian cyst (disease) that involves the corpus luteum.


Large Solitary Luteinized Follicle Cyst of Ovary

A large, unilateral, solitary ovarian cyst lined by luteinized cells, occurring during pregnancy or puerperium. (WHO 2020)


Complex ovarian cyst

A cystic lesion that arises from the ovary. It is characterized by the presence of cystic spaces that contain fluid and a solid tissue component.


Unilocular Ovarian Cyst

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

An ovarian cyst that has a single compartment.


Follicular cyst of ovary

A benign ovarian cyst that develops from a persistent, unruptured Graafian follicle, which grows larger than three centimeters.


Autonomous Ovarian Follicular Cyst

A cyst arising from an ovarian follicle that produces hormones independent of gonadotropin stimulation.


Functional cyst of ovary

A benign ovarian cyst that develops and regresses during the menstrual cycle as part of normal ovarian function.


saturated organic heteromonocyclic parent


carbonic anhydrase 2 isoform 1 (rat)

A vertebrate-type carbonic anhydrase 2 isoform 1 that is encoded in the genome of rat.


Grade 3 Vision Decreased, CTCAE

Marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200)


FIGO Stage IIIB Ovarian Cancer

Ovarian cancer with macroscopic, extrapelvic, peritoneal metastasis equal or less than 2 cm +/- positive retroperitoneal lymph nodes. Includes extension to capsule of liver/spleen. (FIGO, 2014)


Grade 3 Stomach Intra-Operative Injury, CTCAE


Recurrent T Acute Lymphoblastic Leukemia

The reemergence of T-acute lymphoblastic leukemia after a period of remission.


Recurrent Childhood T Acute Lymphoblastic Leukemia

The reemergence of T-acute lymphoblastic leukemia in childhood after a period of remission.


Grade 2 Paronychia, CTCAE

Local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); nail fold edema or erythema with pain; associated with discharge or nail plate separation; limiting instrumental ADL


Grade 1 Stoma GI Stricture or Stenosis, CTCAE


gamma-aminobutyric acid receptor subunit alpha-1 isoform 1 (mouse)

A gamma-aminobutyric acid receptor subunit alpha-1 isoform 1 that is encoded in the genome of mouse.


gamma-aminobutyric acid receptor subunit alpha-1 isoform 1 (rat)

A gamma-aminobutyric acid receptor subunit alpha-1 isoform 1 that is encoded in the genome of rat.


A frizzled-like G-protein coupled receptor that is a translation product of the human FZD8 gene or a 1:1 ortholog thereof.


frizzled-8, signal peptide removed ubiquitinated form (human)

A frizzled-8 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q9H461, 28-694, MOD:01148.


frizzled-8, signal peptide removed form (human)

A frizzled-8 (human) that has had the signal peptide removed. UniProtKB:Q9H461, 28-694.


microtubule-associated protein tau isoform Tau-F phosphorylated 1 (human)

A microtubule-associated protein tau isoform Tau-F phosphorylated 1 in human. UniProtKB:P10636-8, Thr-181, MOD:00047.


Rothmund-Thomson syndrome type 1

Rothmund-Thomson syndrome type 1 is a subform of Rothmund-Thomson syndrome (RTS) presenting with a characteristic facial rash (poikiloderma) and frequently associated with short stature, sparse scalp hair, sparse or absent eyelashes and/or eyebrows, and rapidly progressive bilateral juvenile cataracts. In contrast to RTS2, patients with RTS1 do not appear to have an increased risk of developing cancer.


Rothmund-Thomson syndrome

Rothmund-Thomson syndrome (RTS) is a genodermatosis presenting with a characteristic facial rash (poikiloderma) associated with short stature due to pre- and postnatal growth delay, sparse scalp hair, sparse or absent eyelashes and/or eyebrows, juvenile cataracts, skeletal abnormalities, radial ray defects, premature aging and a predisposition to certain cancers.


Rothmund-Thomson syndrome type 2

Rothmund-Thomson syndrome type 2 is a subform of Rothmund-Thomson syndrome (RTS) presenting with a characteristic facial rash (poikiloderma) and frequently associated with short stature, sparse scalp hair, sparse or absent eyelashes and/or eyebrows, congenital bone defects and an increased risk of osteosarcoma in childhood and squamous cell carcinoma later in life.


FLVCR1-related retinopathy with or without ataxia

A disorder characterized by retinopathy with ataxia in most patients, caused by biallelic variants in the FLVCR1 gene.


posterior column ataxia-retinitis pigmentosa syndrome

Posterior column ataxia - retinitis pigmentosa is characterized by the association of progressive sensory ataxia and retinitis pigmentosa.


Mononegavirales infectious disease

Infections with viruses of the order mononegavirales. The concept includes filoviridae infections; paramyxoviridae infections; and rhabdoviridae infections.


mumps infectious disease

A contagious viral infection caused by the mumps virus. Symptoms include swollen and tender parotid glands, fever, muscle aches and fatigue. Due to vaccination programs, mumps has become a rare disease.


parainfluenza virus type 2 infectious disease

A disease caused by infection with parainfluenza virus type 2.


fetal parainfluenza virus type 3 syndrome

A syndrome caused by HPIV-3.


parainfluenza virus type 3 infectious disease

Parainfluenza virus type 3 is one of a group of common viruses known as human parainfluenza viruses (HPIV) that cause a variety of respiratory illnesses. Symptoms usually develop between 2 and 7 days from the time of exposure and typically resolve in 7-10 days. Symptoms may include fever, runny nose, and cough. HPIV-3 can also cause bronchiolitis, bronchitis, and pneumonia. Infants and young children are particularly susceptible to HPIV-3 infections, though older adults and those with a weakened immune system are also at risk for complications. HPIVs are usually spread from an infected person to others through coughing, sneezing, and/or touching. There is currently no vaccine to protect against parainfluenza virus infections. Most HPIV infections resolve on their own and do not require special treatment, though medical intervention may be necessary for severe breathing problems. Most adults have antibodies against parainfluenza but can get repeat infections.


henipavirus infectious disease

Infections with viruses of the genus henipavirus, family paramyxoviridae.


Rhabdoviridae infectious disease

Virus diseases caused by rhabdoviridae. Important infections include rabies; ephemeral fever; and vesicular stomatitis.


borna disease

An encephalomyelitis of horses, sheep and cattle caused by borna disease virus.


Marburg hemorrhagic fever

Marburg hemorrhagic fever (MHF), caused by Marburg virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure.


morbillivirus infectious disease

Infections with viruses of the genus morbillivirus, family paramyxoviridae. Infections mainly cause acute disease in their hosts, although in some cases infection is persistent and leads to degenerative conditions.


respirovirus infectious disease

Infections with viruses of the genus respirovirus, family paramyxoviridae. Host cell infection occurs by adsorption, via hemagglutinin, to the cell surface.


Paramyxoviridae infectious disease

Infections with viruses of the family paramyxoviridae. This includes morbillivirus infections; respirovirus infections; pneumovirus infections; henipavirus infections; avulavirus infections; and rubulavirus infections.


Filoviridae infectious disease

Infections with viruses of the family filoviridae. The infections in humans consist of a variety of clinically similar viral hemorrhagic fevers but the natural reservoir host is unknown.


parainfluenza virus type 4 infectious disease

A disease caused by infection with parainfluenza virus type 4.


Nipah virus disease

Nipah virus disease, caused by the Nipah virus, is a recently discovered zoonotic disease characterized by fever, constitutional symptoms and encephalitis, sometimes accompanied by respiratory illness.


parainfluenza virus type 1 infectious disease

A disease caused by infection with parainfluenza virus type 1.


parainfluenza infectious disease

A disease caused by infection with parainfluenza virus. There are four serotypes which cause respiratory illnesses in children and adults.


Avulavirus infectious disease

Infections with viruses of the genus avulavirus, family paramyxoviridae. This includes newcastle disease and other infections of domestic fowl.


adult central nervous system choriocarcinoma

A choriocarcinoma of the central nervous system that occurs in an adult.


Ciliary Body Adenoma

A benign neoplasm of the pigmented ciliary epithelium (pigmented epithelial adenoma) and/ or the non-pigmented ciliary epithelium (non-pigmented epithelial adenoma). (WHO 2018)


vascular endothelial growth factor receptor 1 N-glycosylated 4 (human)

A vascular endothelial growth factor receptor 1 (human) that has been N-glycosylated at the residue equivalent to Asn-625 of the amino acid sequence represented by UniProtKB:P17948-1, in which the glycan composition is represented by GlyTouCan:G57776ZU. Example: UniProtKB:P17948-1, Asn-625, MOD:00160~GNO:G57776ZU.


Smouldering systemic mastocytosis

Smouldering systemic mastocytosis is a type of systemic mastocytosis (SM). This clonal hematologic disease, with a slow progression, results in an accumulation of neoplastic mast cells in the visceral organs over time and patients present with splenomegaly, hypercellular marrow and, in some cases, urticaria pigmentosa-like skin lesions.


L-histidine derivative

A proteinogenic amino acid derivative resulting from the formal reaction of L-histidine at the amino group, carboxy group, or the imidazolyl moiety, or from the replacement of any hydrogen of L-histidine by a heteroatom.


progressive myoclonic epilepsy type 9

Any progressive myoclonic epilepsy in which the cause of the disease is a mutation in the LMNB2 gene.


Inflammatory Malignant Fibrous Histiocytoma NCI Grade 2


dipsogenic diabetes insipidus

Diabetes insipidus caused by excessive intake of water due to psychological factors or damage to the thirst-regulating mechanism.