Grade 2 Flushing, CTCAE

Moderate symptoms; limiting instrumental ADL


Malignant Lymphoma, Convoluted

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Cranial Nerve XII Intra-Operative Injury, CTCAE

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Vulvar Merkel Cell Carcinoma

A Merkel cell carcinoma that arises from the vulva. It usually presents as a cutaneous nodular lesion. Most small cell neuroendocrine carcinomas of the vulva are Merkel cell carcinomas.


Leukemia, Eosinophilic, Acute

A poorly defined concept which at best is described as an extremely rare entity, possibly related to various subtypes of acute myeloid leukemia with abnormal eosinophils.  (WHO, 2001)


Stage IA Bone Cancer AJCC v8

Stage IA includes: T1, N0, M0, G1 or GX. T1: Tumor measuring 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


Chondroblastoma, malignant

A rare chondroblastoma that has metastasized to another anatomic site.


Grade 5 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Human Papillomavirus-Related Cervical Adenocarcinoma In Situ

Cervical adenocarcinoma in situ associated with human papillomavirus infection.


Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE


Grade 1 Fallopian Tube Perforation, CTCAE


Condyloma acuminata of vagina

A human papillomavirus-related neoplasm that arises from the vagina. It is characterized by papillomatosis, acanthotic changes, and hyperkeratosis. Koilocytosis is usually present.


Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


Disease due to Papovaviridae

An infection caused by any papovavirus.


Lugano Classification Stage IIE Childhood Hodgkin Lymphoma AJCC v8

Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Grade 3 Neonatal Respiratory Insufficiency, AE

An adverse event in a newborn characterized by clinical evidence of increased respiratory distress with relevant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); requiring major care change (e.g. starting invasive support).


Melanoma Metastatic in the Brain

A melanoma that has spread to the brain from its original site of growth, through the hematogenous route.


Vaginal high grade squamous intraepithelial lesion

Vaginal intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes.


Stage II Low Grade Adult Non-Hodgkin's Lymphoma


Grade 5 Neonatal Constipation, AE

A constipation adverse event in a newborn which results in death.


Grade 2 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Urinary Tract Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 5 Large Intestinal Anastomotic Leak, CTCAE

Death


Grade 5 Acute Vascular Leak Syndrome, CTCAE


Grade 3 Nervous System Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Facial Muscle Weakness, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


AIDS-Related Human Papillomavirus Infection

An opportunistic infection caused by the human papillomavirus in a patient with AIDS.


Stage III Fallopian Tube Cancer AJCC v7

Stage III includes: (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c, N0, M0); (Any T, N1, M0).  T3: Tumor involves one or both fallopian tubes, with peritoneal implants outside the pelvis.  T3a: Microscopic peritoneal metastasis outside the pelvis.  T3b: Macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis outside the pelvis and more than 2 cm in diameter.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 5 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Bronchopulmonary Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


small cell carcinoma of anal canal

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal.  It is characterized by the presence of malignant small cells.


Mixed cell adenocarcinoma

An adenocarcinoma characterized by the presence of a mixed malignant glandular cell population.


Grade 5 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

Death


Chest Pain Along Left Lower Sternal Border

The location of the chest pain is along the left lower border of the sternum.


Grade 3 Typhlitis, CTCAE

Symptomatic (e.g., abdominal pain, fever, change in bowel habits with ileus); peritoneal signs


Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma

Renal pelvis and ureter urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage III Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 3 Stridor, CTCAE

Respiratory distress limiting self care ADL; medical intervention indicated


Grade 3 Thyroid Intra-Operative Injury, CTCAE


Grade 2 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Social Circumstances - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Common Carotid Trunk

Common origin for left subclavian and left carotid arteries.


Central Nervous System Rosai-Dorfman Disease

Rosai-Dorfman disease affecting the central nervous system. It presents with localized or multiple dural masses, parenchymal, and/or intrasellar lesions.


Stage IIIC2 Cervical Cancer FIGO 2018

Cervical carcinoma with para-aortic lymph node metastasis. (FIGO 2018)


Malignant tumor of seminal vesicle

A primary or metastatic malignant neoplasm that affects the seminal vesicle.


Duodenal Fistula, CTCAE

A disorder characterized by an abnormal communication between the duodenum and another organ or anatomic site.


Grade 4 Lower Extremity Artery Injury, CTCAE


Grade 3 Gastrointestinal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Definite Adverse Event Attribution to Product or Procedure

Definite adverse event attribution to study product or procedure is established when there is a clear-cut temporal association between product or procedure administration and adverse event, and no other possible cause is present.


Grade 3 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Gallbladder Cancer by AJCC v8 Stage

A term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to gallbladder carcinomas. Well-differentiated neuroendocrine tumors and sarcomas are not staged using this staging system. (from AJCC 8th Ed.)


Grade 1 Intraoperative Head and Neck Injury, CTCAE

Primary repair of injured organ/structure indicated


Stage I Vaginal Cancer AJCC v6 and v7

Stage I includes: (T1, N0, M0).  T1: Tumor confined to vagina.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 2 External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Stoma Site Infection, CTCAE

Death


Grade 5 Cranial Nerve IV Neuropathy, CTCAE


Grade 2 Prostate Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage 0 Uterine Corpus Cancer AJCC v6

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Bronchus Infection with Unknown Absolute Neutrophil Count, CTCAE


Leptomeningeal Neoplasms

A malignant neoplasm that has spread from its original site to the two innermost layers of tissue that cover the brain and spinal cord.


Grade 3 Tracheal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Secondary Osteosarcoma

An osteosarcoma arising from a pre-existing lesion of the bone, usually Paget disease, or due to radiation therapy.


Grade 4 Cranial Nerve V Motor Intra-Operative Injury, CTCAE


Grade 2 Dermatitis Radiation, CTCAE

Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema


Grade 4 Liver Dysfunction or Failure by Clinical Classification, CTCAE


Grade 1 Rectal Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Grade 5 Gallbladder Perforation, CTCAE

Death


Refractory Primary Malignant Central Nervous System Neoplasm

A primary malignant central nervous system neoplasm that is resistant to treatment.


Grade 5 Small Bowel Stricture or Stenosis NOS, CTCAE


Grade 4 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Laryngeal Edema, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 1 Oral Intra-Operative Injury, CTCAE


Grade 2 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Delirium, CTCAE

Life-threatening consequences, threats of harm to self or others; urgent intervention indicated


Grade 1 Peritoneal Cavity Hemorrhage, CTCAE


Grade 3 Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Meningitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated; focal neurologic deficit


Grade 2 Bladder Stricture or Stenosis, CTCAE


Grade 5 Jejunal Ulcer, CTCAE

Death


Grade 3 Metabolic or Respiratory Acidosis, CTCAE


Hypertensive episode

An episode of elevated blood pressure.


Grade 3 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 4 Prolonged Intubation After Pulmonary Resection, CTCAE


Grade 4 Heart Failure, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support)


Grade 1 Cartilage Intra-Operative Injury, CTCAE


Refractory Chemotherapy-Induced Nausea and Vomiting

Chemotherapy-induced nausea and vomiting that does not respond to treatment.


Grade 3 Nails Intra-Operative Injury, CTCAE


Bladder Perforation, CTCAE 5.0

A disorder characterized by a rupture in the bladder wall.


Congenital Phrenic Nerve Injury

Damage to the phrenic nerve that is present at birth.


Conjunctival Reactive Epithelial Hyperplasia

A non-neoplastic proliferation of the conjunctival epithelium in response to irritating stimuli.


Muscle Invasive Bladder Carcinoma

A carcinoma that arises from the bladder mucosa and invades the muscle of the bladder wall.


Tearing Pain

An intense sensation of discomfort or distress that feels like being torn or ripped apart.


Stage IIA Appendix Carcinoma AJCC v8

Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Increased Creatinine

A laboratory test result demonstrating an increased concentration of creatinine in a biological specimen.


Childhood Non-T Non-B Acute Lymphoblastic Leukemia

Non-T non-B acute lymphoblastic leukemia that occurs during childhood.


Grade 4 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Somnolence, CTCAE

Mild but more than usual drowsiness or sleepiness


Non-organic enuresis

Involuntary urine release that cannot be attributed to an anatomic or physiologic etiology.


Malignant Trophoblastic Teratoma

A malignant germ cell tumor which metastasizes widely and produces high levels of human chorionic gonadotropin.


Disturbance of Temperature Regulation

Any condition characterized by an inability to regulate body temperature.


Grade 2 Hepatic Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Puerperal sepsis

A sustained temperature of 38C (100.4F) or greater beyond the first 24 hours following birth, or a temperature of 39C (102.2F) within the first 24 hours following birth. (adapted from ACOG)


Grade 5 Bone Infection, CTCAE

Death


Non-Destructive Post-Transplant Lymphoproliferative Disorder

A lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by the lack of tissue destruction and the architectural preservation of the involved tissues.  It includes two morphologic variants: plasmacytic hyperplasia and infectious mononucleosis-like lymphoproliferative disorders.


Grade 3 Metabolic or Respiratory Alkalosis, CTCAE


Non-T Non-B CALLA Positive Childhood Acute Lymphoblastic Leukemia

A non-T, non-B, acute lymphoblastic leukemia in which the lymphoblasts are positive for the common acute lymphoblastic leukemia antigen (CALLA) occurring in children.


Fibrosarcoma metastatic

Fibrosarcoma that has spread from its original site of growth to another anatomic site.


Grade 2 Small Intestinal Stenosis, CTCAE

Symptomatic; altered GI function


Grade 3 Uterus Intra-Operative Injury, CTCAE


Dermatitis Radiation, CTCAE

A finding of cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation.


Recurrent Urothelial Carcinoma of the Renal Pelvis and Ureter

Reemergence of transitional cell carcinoma of the renal pelvis and ureter after a period of remission.


Gallbladder Papillary Biliary Intraepithelial Neoplasia

Biliary intraepithelial neoplasia that affects the gallbladder epithelium.  It is characterized by the presence of intraluminal micropapillary projections.


Stage III Cutaneous Melanoma AJCC v6

Stage III includes: (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  N1: Metastasis in one lymph node.  N2: Metastasis in two to three regional lymph nodes or intralymphatic regional metastasis without nodal metastases.  N3: Metastasis in four or more regional nodes, or matted metastatic nodes, or in-transit metastasis or satellite(s) with metastasis in regional node(s).


Neuroendocrine carcinoma of prostate

A small cell or rarely a large cell neuroendocrine carcinoma that arises from the prostate gland.


Grade 4 Cranial Nerve V Neuropathy, CTCAE


Grade 3 Paroxysmal Atrial Tachycardia, CTCAE

Symptomatic, urgent intervention indicated; ablation


Grade 4 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Grade 3 Oral Cavity Fistula, CTCAE

Invasive intervention indicated


Injury To Superior Vena Cava, CTCAE

A finding of damage to the superior vena cava.


Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Breast Function and Lactation, CTCAE


Malignant sex-cord stromal tumor

A gonadal sex cord-stromal tumor with malignant characteristics.  It includes the poorly differentiated ovarian Sertoli-Leydig cell tumor, malignant ovarian granulosa cell tumor, malignant ovarian steroid cell tumor, and malignant ovarian thecoma.


Functional encopresis

An elimination disorder characterized by fecal incontinence, whether involuntary or intentional, which is not due to a medical condition and which occurs in someone who is toilet trained.


Polygonal cell carcinoma

A malignant epithelial neoplasm composed of atypical polygonal cells with a large amount of eosinophilic cytoplasm. A representative example is the fibrolamellar hepatocellular carcinoma.


Gastritis, CTCAE

A disorder characterized by inflammation of the stomach.


Grade 5 Hypertension, CTCAE

Death


Grade 1 Neonatal Gastrointestinal Bleeding, AE

A gastrointestinal bleeding adverse event in a newborn characterized by mild, self-limiting, bleeding; no change in care required.


Myocarditis, CTCAE 5.0

A disorder characterized by inflammation of the muscle tissue of the heart.


Grade 2 Adrenal Gland Intra-Operative Injury, CTCAE


Grade 1 Cough, CTCAE

Mild symptoms; nonprescription intervention indicated


Grade 3 Hepatic Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 Inner Ear Intra-Operative Injury, CTCAE


Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Cartilage Intra-Operative Injury, CTCAE


IgG Monoclonal Gammopathy

An abnormal laboratory test result indicating the presence of IgG monoclonal immunoglobulin in the blood or urine.


Grade 2 Infant Irritability, AE

An adverse event in a newborn characterized by moderate irritability, minor changes in feeding and sleeping behavior, requiring minor additional care (e.g. occasional analgesics).


Grade 3 Testis Intra-Operative Injury, CTCAE


Grade 5 Bronchus Obstruction and Stenosis, CTCAE


Grade 4 Hypoglycemia, CTCAE

<30 mg/dL; <1.7 mmol/L; life-threatening consequences; seizures


Recurrent Pancreatic Acinar Cell Carcinoma

The reemergence of pancreatic acinar cell carcinoma after a period of remission.


Perceptual disturbance

A misperception of sensory stimuli.


Grade 2 Hemorrhoids, CTCAE

Symptomatic; banding or medical intervention indicated


Grade 5 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

Death


Recurrent Malignant Peripheral Nerve Sheath Tumor

The reemergence of malignant peripheral nerve sheath tumor after a period of remission.


Grade 4 Vaginal Perforation, CTCAE

Life-threatening consequences; urgent intervention indicated


Retinal Pigment Epithelium Adenocarcinoma

An adenocarcinoma that arises from the retinal pigment epithelium. The prognosis is good if the tumor has not extended extraocularly.


Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-MLL

An acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-MLL occurring in adults.


Grade 5 Non-Myocardial Visceral Arterial Ischemia, CTCAE


Grade 1 Hemoglobin Increased, CTCAE

Increase in >0-2 g/dL


Lugano Classification Stage II Hodgkin Lymphoma AJCC v8

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Biliary Fistula, CTCAE

A disorder characterized by an abnormal communication between the bile ducts and another organ or anatomic site.


Grade 1 Parathyroid Intra-Operative Injury, CTCAE


Clinical Stage IIB Cutaneous Melanoma AJCC v8

Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0). T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Worst Imaginable Pain

The most severe pain an individual can conceive of experiencing.


Refractory Pancreatic Carcinoma

Pancreatic carcinoma that does not respond to treatment.


Lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Locally Advanced Basal Cell Carcinoma

A basal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Brain Ependymoma

An ependymoma that arises from the brain.


T-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant

A T-cell prolymphocytic leukemia characterized by the presence of neoplastic prolymphocytes with irregular or cerebriform nuclear outline.


Grade 1 Dental Caries, CTCAE

One or more dental caries, not involving the root


Grade 3 Uterine Obstruction, CTCAE

Severe symptoms; invasive intervention indicated


Gliomatosis Cerebri Type II

A classic form of gliomatosis cerebri. It is characterized by diffuse growth of neoplastic glial tissue without any focal mass.


Grade 2 Hoarseness, CTCAE

Moderate or persistent voice changes; may require occasional repetition but understandable on telephone; medical evaluation indicated


Adnexal Secretory Carcinoma

A rare adnexal carcinoma that is histopathologically identical to homologous lesions in the salivary gland and breast. (WHO 2018)


Grade 5 Biliary Anastomotic Leak, CTCAE

Death


Decreased or absent activity of the enzyme 17-alpha-hydroxylase/17,20 lyase due to loss-of-function mutation(s) in the CYP17A1 gene. The clinical manifestations of the deficiency are dependent on whether one or both activities of the enzyme are affected, and may include hypertension due to reduced 17-hydroxylase activity and incomplete genital masculinization in 46,XY infants due to reduced 17,20 lyase activity.


Grade 1 Rectum Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Malignant hepatobiliary neoplasms

A malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder.  Representative examples include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Grade 5 Anemia, CTCAE

Death


Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE


Stage III Bladder Cancer AJCC v8

Stage III includes: IIIA: (T3a, T3b, T4a, N0, M0); (T1-T4a, N1, M0); IIIB: (T1-T4a, N2, N3, M0). T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T3a: Tumor invades perivesical soft tissue, microscopically. T3b: Tumor invades perivesical soft tissue, macroscopically (extravesical mass). T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node). N2: Multiple regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node metastasis). N3: Lymph node metastasis to the common iliac lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Acquired postural kyphosis

Postural kyphosis, the cause of which is not present at birth.


Grade 4 Hypercalcemia, CTCAE

Corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences


Proliferative retinopathy

Retinopathy characterized by the formation of new vessels in the retina. The new vessels are abnormal and fragile. If hemorrhage occurs due to the vascular fragility, there is increased risk of vision loss or blindness.


Grade 5 Duodenal Obstruction, CTCAE

Death


Neonatal aspiration of amniotic fluid

Inhalation of fluid from the amniotic sac into the lungs by the neonate.


Grade 3 Duodenum Stricture or Stenosis, CTCAE


Grade 4 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cardiac Troponin T Increased, CTCAE

A finding based on laboratory test results that indicate increased levels of cardiac troponin T in a biological specimen.


squamous cell papilloma of anal canal

A benign epithelial neoplasm that arises from the anal canal.  It is characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy.


Grade 5 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Rectal Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the rectal wall.


Major Visceral Vein Intra-Operative Injury, CTCAE


Grade 2 Portal Vein Thrombosis, CTCAE

Intervention not indicated


Recurrent Epithelioid Malignant Peripheral Nerve Sheath Tumor

The reemergence of an epithelioid malignant peripheral nerve sheath tumor after a period of remission.


Grade 3 Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Gastrointestinal Stoma Obstruction, CTCAE


Grade 4 Nose Intra-Operative Injury, CTCAE


Grade 1 Laryngeal Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Intraoperative Endocrine Injury, CTCAE

Primary repair of injured organ/structure indicated


Stage II Gestational Trophoblastic Tumor AJCC v7

Stage II includes: (T2, M0, Risk factors: unknown); IIA (T2, M0, Risk factors: low risk); IIB (T2, M0, Risk factors: high risk).  T2: Tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Fallopian Tube Stricture or Stenosis, CTCAE


Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Skin Induration, CTCAE

Generalized; associated with signs or symptoms of impaired breathing or feeding


Grade 3 Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Anemia (mild)

Anemia not associated with symptoms of fatigue, headaches, palpitations, or shortness of breath. In asymptomatic anemia the hematocrit levels usually range from 32 to 35%.


Grade 3 Cranial Nerve II Neuropathy, CTCAE


Grade 1 Rhinorrhea, CTCAE

Present


Esophageal Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the esophageal region.


Grade 2 Jejunal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 3 Pancreatic Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 5 Mitral Valve Disease, CTCAE

Death


Stage I Childhood Large Cell Lymphoma

Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Intraocular Schwannoma

A benign schwannoma occurring in the eye.


Low LDH Level

A lower than average level of lactate dehydrogenase in a sample.


Recurrent Childhood Lymphoma

The reemergence of a childhood Hodgkin or non-Hodgkin lymphoma after a period of remission.


A pilomyxoid astrocytoma occurring in the hypothalamic-chiasmatic region.


Sudden Death NOS, CTCAE

An unexpected death that cannot be attributed to a CTCAE term associated with Grade 5.


Hypoglycemia, CTCAE

A disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood.


Oncotype DX Breast Cancer Recurrence Score Less than or Equal to Eighteen

A genetic finding indicating that the Oncotype DX breast cancer recurrence score for a sample was less than or equal to 18.


Relapsing classical Hodgkin lymphoma

The reemergence of classic Hodgkin lymphoma after a period of remission.


Borderline Fallopian Tube Serous Tumor

A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by an atypical proliferation of serous-type epithelial cells without evidence of stromal invasion.


Refractory Mature T-Cell and NK-Cell Neoplasm

Mature T-cell and NK-cell neoplasm that is resistant to treatment.


Grade 3 Memory Impairment, CTCAE

Severe memory impairment; limiting self care ADL


Rhesus hemolytic disease of newborn

A disorder caused when there is a Rh-factor blood-type incompatibility between the mother and fetus, and the mother's immune system forms antibodies that attack the red blood cells of her unborn child. This disorder can only occur if the mother is Rh-negative and the fetus is Rh-positive.


Grade 1 Proptosis and Enophthalmos, CTCAE


Old myocardial infarction

Documented history of previous myocardial infarction (MI), typically with objective evidence via positive biomarkers of myocardial necrosis.


Acquired macrocephaly

A non-congenital condition in which the head circumference is two standard deviations greater than the mean. Causes include infection, intraventricular hemorrhage, subdural hematoma, and arachnoid cysts.


Infective cervicitis

An infectious process affecting the uterine cervix. Causative agents include Neisseria gonorrhoeae, Chlamydia trachomatis, human papillomavirus, and herpes simplex virus. Physical examination reveals an erythematous, raised lesion in the cervix and mucopurulent discharge.


Grade 3 Other Blood and Bone Marrow, CTCAE


Grade 3 Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Crypt abscess (morphologic abnormality)

Accumulation of polymorphonuclear neutrophils in the mucosal crypts of the colon. It occurs in ulcerative colitis.


Grade 3 Dysmenorrhea, CTCAE

Severe symptoms; limiting self care ADL


Intraductal Hyperplasia

A hyperplasia of the intraductal cells.


Grade 5 Investigations - Other, Specify, CTCAE

Death


Infiltrating Urothelial Carcinoma, Sarcomatoid Variant

An invasive urothelial carcinoma that exhibits spindle cell sarcomatoid features.


Grade 2 Budd-Chiari Syndrome, CTCAE

Medical management indicated


Grade 1 Pulmonary Vein Intra-Operative Injury, CTCAE


Hypersexualism

Excessive sexual behavior.


Grade 5 Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE

Death


Grade 3 Cranial Nerve XII Neuropathy, CTCAE


Grade 1 Anal Mucositis, CTCAE

Asymptomatic or mild symptoms; intervention not indicated


Secondary Prostate Urothelial Carcinoma

A transitional cell carcinoma that has spread to the prostate gland directly from the bladder.


Grade 2 Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Refractory Acute Leukemia

Acute leukemia that does not respond to treatment.


Alcohol Related Neurodevelopmental Disorder

A cognitive and neurological disorder due to fetal intrauterine exposure to maternal alcohol consumption. Typically, this presents without facies or other growth abnormalities.


Herpes Simplex Reactivation, CTCAE

A disorder characterized by the reactivation of Herpes simplex virus


Grade 1 Gastric Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


Grade 3 Voice Alteration, CTCAE

Severe voice changes including predominantly whispered speech; may require frequent repetition or face-to-face contact for understandability; may require assistive technology


An epithelioid hemangioendothelioma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Vision Decreased, CTCAE

Moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


Grade 2 Abdomen Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Ovarian Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Grade 4 Intraoperative Hemorrhage, CTCAE


Liver Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the liver. The mitotic count is 2-20 per 10 HPF.


Trachea Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Spinal Fracture, CTCAE

Mild back pain; nonprescription analgesics indicated


Grade 3 Nose Intra-Operative Injury, CTCAE


Grade 5 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Diffuse malignant lymphoma - large cleaved cell

Antiquated term describing non-Hodgkin lymphomas that are usually diffuse and are composed of large cells with irregular nuclei, invisible nucleoli and a small amount of cytoplasm.  This morphologic category includes both mature B- and mature T-cell lymphomas.


Stage I Bladder Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invades lamina propria (subepithelial connective tissue). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Pseudomonas-Related Vasculitis

A necrotizing vasculitis caused by Pseudomonas aeruginosa.


Grade 2 Chronic Kidney Disease, CTCAE

eGFR or CrCl 59-30 ml/min/1.73 m2


Vaginal adenocarcinoma metastatic

An adenocarcinoma that arises from the vagina and has metastasized to other anatomic sites.


Skin Papilloma, CTCAE

A disorder characterized by the presence of one or more warts.


Grade 3 Upper Airway NOS Intra-Operative Injury, CTCAE


Grade 5 Peripheral Nerve Infection, CTCAE

Death


Physical addiction

The neuroadaptation of the body to the presence of an opioid, and is characterized by the onset of acute symptoms and signs of withdrawal if the opioid is stopped or an opioid antagonist is administered.


Grade 3 Feeding Intolerance, AE

An adverse event in a newborn characterized by severe feeding intolerance; requiring major changes in feeding support indicated (e.g. change to total parenteral nutrition (TPN) or gavage).


Stage III Cervical Cancer AJCC v6 and v7

Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T1, N1, M0), (T2, N1, M0), (T3a, N1, M0), (T3b, Any N, M0). T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non functioning kidney.  N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 3 Enterocolitis, CTCAE

Severe or persistent abdominal pain; fever; ileus; peritoneal signs


Mixed Phenotype Acute Leukemia, Not Otherwise Specified, Rare Subtypes

A very rare group of mixed phenotype acute leukemias, not otherwise specified in which the blasts show clear-cut evidence of both B-cell and T-cell lineage or evidence of trilineage (B-cell, T-cell, and myeloid lineage) assignment. (WHO 2017)


A lymphoproliferative disorder caused by the human herpesvirus HHV8. This category includes HHV8-positive multicentric Castleman disease, HHV8-positive diffuse large B-cell lymphoma, not otherwise specified, and germinotropic lymphoproliferative disorders.


Grade 2 Cranial Nerve VIII Neuropathy, CTCAE


Grade 3 Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Small Intestine Infection, CTCAE

Death


Unresectable Ureter Urothelial Carcinoma

Ureter urothelial carcinoma that is not amenable to surgical resection.


Grade 5 Hypopituitarism, CTCAE

Death


Grade 2 Paroxysmal Atrial Tachycardia, CTCAE

Non-urgent medical intervention indicated


Abnormal Vital Capacity

A pulmonary function test result indicating an abnormal vital capacity as compared to the predicted value.


Grade 1 Hiccups, CTCAE

Mild symptoms; intervention not indicated


Grade 1 Dysesthesia, CTCAE

Mild sensory alteration


Fredrickson Type III lipidaemia

A laboratory test result indicating an inheritable form of dysbetalipoproteinemia, in which there are excess intermediate-density lipoproteins in the blood.


Grade 1 Hypocalcemia, CTCAE

Corrected serum calcium of <LLN-8.0 mg/dL; <LLN-2.0 mmol/L; Ionized calcium <LLN-1.0 mmol/L


Grade 2 Heart Infection with Unknown Absolute Neutrophil Count, CTCAE


Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Biliary Tree Common Bile Duct Intra-Operative Injury, CTCAE


Grade 5 Periorbital Infection, CTCAE

Death


Juvenile Dermatomyositis Sine Myositis

A rare form of juvenile dermatomyositis that manifests with characteristic cutaneous findings for at least six months in the absence of any detectable muscle involvement.


Advanced Cutaneous Melanoma

Cutaneous melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Pancreatic Duct Stenosis, CTCAE

Symptomatic; altered GI function


Stage IVA Prostate Cancer AJCC v8

Stage IVA includes: Any T, N1, M0, PSA: Any, Grade Group: Any. N1: Prostate cancer with metastases in regional node(s). M0: Prostate cancer without evidence of distant metastasis. (AJCC 8th ed.)


Stage 0 Digestive System Neuroendocrine Tumor AJCC v7

Stage 0 includes: Tis, N0, M0.  Tis (applies only to stomach): Carcinoma in situ/dysplasia (tumor size less than 0.5 mm), confined to mucosa. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Non-Metastatic Mass

A benign or malignant solid pathologic process that has not spread from its site of origin to another anatomic site.


Grade 3 Enterovesical Fistula, CTCAE

Invasive intervention indicated


Grade 3 Teeth Intra-Operative Injury, CTCAE


Grade 4 Anal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Blood Antidiuretic Hormone Abnormal, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Metastatic malignant neoplasm to brain

A malignant neoplasm that has spread to the brain from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas).


Fetal Growth Retardation, CTCAE

A disorder characterized by inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight.


Hallucinogen dependence, episodic

Physical and psychological dependence on hallucinogenics, which is associated with a pattern of episodic use.


Stage IIA Ampulla of Vater Cancer AJCC v7

Stage IIA includes: T3, N0, M0.  T3: Tumor invades the pancreas.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 5 Budd-Chiari Syndrome, CTCAE

Death


Grade 1 Radiation Recall Reaction (Dermatologic), CTCAE

Faint erythema or dry desquamation


Grade 3 Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Refractory Myelofibrosis

Myelofibrosis that is resistant to treatment.


Grade 5 Somnolence, CTCAE

Death


Grade 2 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Unresectable Malignant Digestive System Neoplasm

A malignant digestive system neoplasm that is not amenable to surgical resection.


Metastatic Fallopian Tube Carcinoma

A carcinoma that arises from the fallopian tube and has metastasized to another anatomic site.


Appendix Perforation, CTCAE

Appendix Perforation that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


Grade 5 Disease Progression, CTCAE

Death


Grade 2 Mitral Valve Disease, CTCAE

Asymptomatic; moderate regurgitation or stenosis by imaging


Peripheral Motor Nerve NOS Intra-Operative Injury, CTCAE


Monoclonal Gammopathy of Renal Significance

A condition caused by a B-cell or plasma cell clone resulting in the deposition of the secreted monoclonal immunoglobulin, without evidence for overt lymphoma or myeloma. This category includes a wide spectrum of renal pathology and include such lesions as immunoglobulin-associated amyloidosis, the monoclonal immunoglobulin deposition diseases (MIDDs; light chain deposition disease, heavy chain deposition disease, and light and heavy chain deposition disease), proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID), C3 glomerulopathy with monoclonal gammopathy, light chain proximal tubulopathy (Fanconi syndrome), and several others.


Grade 1 Anosmia, CTCAE

Present


No Radiating Chest Pain

An indication that the chest pain dose not radiate.


Cranial Nerve VI Intra-Operative Injury, CTCAE


Grade 5 Salivary Gland Fistula, CTCAE

Death


Grade 5 Infective Myositis, CTCAE

Death


Grade 2 Lower Extremity Soft Tissue Necrosis, CTCAE


Grade 2 Intraoperative Gastrointestinal Injury, CTCAE

Partial resection of injured organ/structure indicated


Outer Ear Pinna Intra-Operative Injury, CTCAE


Grade 1 Cranial Nerve X Intra-Operative Injury, CTCAE


Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Pancreatic Duct Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Anxiety, CTCAE

Severe symptoms; limiting self care ADL; hospitalization indicated


Stage III Esophageal Cancer

Stage III includes: T3, N1, M0 and T4, Any N, M0) T3: Tumor invades adventitia. T4: Tumor invades adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) -2003


Stage IV Digestive System Neuroendocrine Tumor AJCC v7

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis.  (AJCC 7th ed.)


Scrotal Cyst

A cystic lesion located in the scrotum.


International Normalized Ratio of Prothrombin Time Level Finding

A finding that indicates the international normalized ratio of prothrombin time level in a sample.


Stage I Digestive System Neuroendocrine Tumor AJCC v7

Stage I includes: T1, N0, M0.  T1: Stomach: tumor invades lamina propria or submucosa and is 1 cm or less in size; duodenum /jejunum/ileum: tumor invades lamina propria or submucosa and is 1 cm or less in size; ampulla: tumor 1 cm or less; colon or rectum: tumor invades lamina propria or submucosa and is 2 cm or less.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 5 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Spleen Intra-Operative Injury, CTCAE


Colonic Hemorrhage, CTCAE

A disorder characterized by bleeding from the colon.


Grade 5 Esophageal Perforation, CTCAE

Death


Neonatal encephalopathy

Abnormal functioning of the central nervous system in the newborn period that may be due to a variety of etiologies including hypoxia/ischemia, metabolic disturbance, or infection.


Grade 1 Rash Acneiform, CTCAE

Papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness


Grade 4 Forced Expiratory Volume Decreased, CTCAE


Pre-Pre-B Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia of early B-lineage.


Grade 5 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Advanced Pancreatic Neuroendocrine Neoplasm

A pancreatic neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Fallopian Tube Stricture or Stenosis, CTCAE


Grade 2 Injury To Inferior Vena Cava, CTCAE

Symptomatic; repair or revision not indicated


Metastatic Bladder Urothelial Carcinoma

Bladder urothelial carcinoma that has spread to another anatomical site.


Grade 4 Myocardial Infarction, CTCAE

Life-threatening consequences; hemodynamically unstable


Metastatic Malignant Peripheral Nerve Sheath Tumor

The presence of malignant Schwann cell growth (benign variant is known as neurofibroma) at a site removed from the primary site of tumor growth.


undifferentiated carcinoma of cervix

A rare carcinoma that arises from the cervix and is characterized by the lack of specific cellular differentiation.


Simple dislocation, multiple and ill-defined sites

Multiple bone displacements without clear distinction that are not associated with an external wound.


Ovarian Hemorrhage, CTCAE

A disorder characterized by bleeding from the ovary.


Refractory Non-Muscle Invasive Bladder Urothelial Carcinoma

Non-muscle invasive bladder urothelial carcinoma that is resistant to treatment.


Grade 2 Bruising, CTCAE

Generalized


Adult Mixed Cellularity Classical Hodgkin Lymphoma

Mixed cellularity classic Hodgkin lymphoma occurring in adults.


Prostate Neuroendocrine Tumor

An extremely rare slow-growing neuroendocrine tumor affecting the prostate gland.


Acute Myelomonocytic Leukemia without Abnormal Eosinophils

Acute myelomonocytic leukemia without an abnormal eosinophilic component in the bone marrow.


Acquired Factor XII Deficiency

An acquired coagulation disorder characterized by the partial or complete absence of factor XII activity in the blood.


Diffuse Laminar Endocervical Hyperplasia

A benign band-like proliferation of tightly-packed, small to medium sized endocervical glands below the surface of the endocervical canal.


Grade 4 Colon Intra-Operative Injury, CTCAE


Grade 3 Tracheal Obstruction, CTCAE

Stridor or respiratory distress limiting self care ADL; invasive intervention indicated (e.g., stent, laser)


Grade 1 Cranial Nerve V Neuropathy, CTCAE


Mesenteric abscess

An abscess that is located in any part of the tissue composing the mesentery, and that generally arises from an infection in an adjacent area of the intestine.


Accident involving aircraft, NOS

An accident taking place aboard, or involving, any type of aircraft.


Grade 2 Infections and Infestations - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Erythema Multiforme, CTCAE

A disorder characterized by target lesions (a pink-red ring around a pale center).


Refractory Erdheim-Chester Disease

Erdheim-Chester disease that does not respond to treatment.


Stage IV Cervical Cancer AJCC v8

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


Grade 3 Alkalosis, CTCAE

pH >7.5


Stage IV Gastric Cancer with Metastasis

T4,N2,MO (from PDQ)


Stage IIIB Vulvar Cancer AJCC v8

Stage IIIB includes: T1-T2, N2a, N2b, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N2a: Three or more lymph node metastases each less than 5 mm. It includes micrometastasis, N2mi. N2b: Two or more lymph node metastases equal to 5 mm. M0: No distant metastasis. (AJCC 8th Ed.)


Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Neonatal Diarrhea, AE

An adverse event in a newborn characterized by an increase of 4 - 6 stools per day over baseline; moderate increase in ostomy output compared to baseline.


Grade 3 Edema Face, CTCAE

Severe swelling; limiting self care ADL


Grade 1 Stomal Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Benzene-Related Acute Myeloid Leukemia

Acute myeloid leukemia caused by benzene.


Decreased CYBA Expression

An indication that the expression of CYBA is lower than the normal range of values.


Grade 1 Nail Changes, CTCAE

Present


Grade 3 Conjunctivitis Infective, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Face NOS Intra-Operative Injury, CTCAE


Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Penile Infection

An infectious process affecting the penis.


Grade 2 Scrotal Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Oral Multifocal Epithelial Hyperplasia

Benign multifocal squamous epithelial proliferation affecting the oral mucosa. It is associated with human papilloma virus infection.


Syringomyelia and Hydromyelia

Syringomyelia associated with accumulation of cerebrospinal fluid in the spinal cord.


Grade 2 Superior Vena Cava Intra-Operative Injury, CTCAE


Grade 3 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Burn, CTCAE

Life-threatening consequences


Non-Infectious Wound Complication, CTCAE


Grade 4 Laryngeal Stenosis, CTCAE

Life-threatening consequences; urgent intervention indicated


Palsy of vagus nerve

Partial or complete paralysis of the vagus nerve.


Grade 3 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Facial Nerve Palsy Related to Birth

A condition characterized by reduced or absent movement of the ipsilateral face as a consequence of an injury to the seventh cranial nerve sustained during the birthing process.


Grade 5 Pericarditis, CTCAE

Death


Grade 3 Myasthenia Gravis, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Renal Colic, CTCAE

A disorder characterized by paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of crystals/kidney stones.


Grade 2 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


FIGO Stage IIIC Gestational Trophoblastic Tumor


Grade 1 Optic Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only


Squamous cell carcinoma, clear cell type

A squamous cell carcinoma characterized by the presence of malignant cells with clear cytoplasm.


Transitional cell cancer of renal pelvis and ureter metastatic

A transitional cell carcinoma of the renal pelvis and ureter which has spread from its original site of growth to another anatomic site.


Grade 1 Intraoperative Urinary Injury, CTCAE

Primary repair of injured organ/structure indicated


Broad Ligament Ependymoma

A rare neoplasm that arises from the broad ligament and shows ependymal differentiation.


Appendix Serrated Lesions and Polyps

Polyps that arises from the appendix. They are characterized by the presence of serrated glands and the absence of generalized dysplasia.


Grade 5 Upper Gastrointestinal Hemorrhage NOS, CTCAE


Recurrent Neuroendocrine Carcinoma

The reemergence of neuroendocrine carcinoma after a period of remission.


COVID-19-Associated Ataxia

Ataxia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Grade 2 Cranial Nerve I Neuropathy, CTCAE


Thrush, CTCAE

A disorder characterized by a suspected candidal infection involving an oral mucosal surface.


Atypical meningioma

A WHO grade II meningioma characterized by the presence of brain invasion and an increased mitotic activity, or at least three of the following morphologic features: small cells, high cellularity, prominent nucleoli, lack of architectural pattern, and necrosis.


Grade 1 Hyperlipidemia, CTCAE

Requiring diet changes


Stage IVA Osteosarcoma AJCC v7

Stage IVA includes: Any T, N0, M1a, Any G.  N0: No regional lymph node metastasis.  M1a: Distant metastasis to lung. (AJCC 7th ed.)


Grade 4 Bronchus Intra-Operative Injury, CTCAE


Bone island

An osteoma that develops in the medullary cavity of the bone.


Blood Lactate Dehydrogenase Increased, CTCAE

A finding based on laboratory test results that indicate increased levels of lactate dehydrogenase in the blood specimen.


Grade 2 Watering Eyes, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


Grade 3 Pericardial Effusion, CTCAE

Effusion with physiologic consequences


Acute Myeloid Leukemia Arising from Previous Myeloproliferative Neoplasm

An acute myeloid leukemia developing in patients with a prior history of myeloproliferative neoplasm.


Grade 1 Neonatal Respiratory Distress Syndrome, AE

An adverse event in a newborn characterized by radiological evidence without clinical signs; clinical evidence of mildly increased respiratory distress (e.g. increased work of breathing) without significant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); no supportive care required.


Grade 3 Sinus Disorder, CTCAE

Stenosis with significant nasal obstruction; limiting self care ADL


Recurrent Hepatocellular Carcinoma

The reemergence of hepatocellular carcinoma after a period of remission


Grade 1 Adrenal Insufficiency, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Oral Cavity Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Vaginal Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 2 Abdomen Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Sinus perforation

A rupture in the sinus tissue due to traumatic or pathologic processes.


Post-Mastectomy Pain Syndrome

Chronic pain following mastectomy or lumpectomy that usually affects the anterior thorax, axilla, and/or medial upper arm.


Grade 1 Other Pulmonary and Upper Respiratory, CTCAE


Grade 4 Laryngospasm, CTCAE

Persistent or severe episodes associated with syncope; urgent intervention indicated (e.g., fiberoptic laryngoscopy, intubation, botox injection)


Radiation Damage

Injury resulting from exposure to ionizing radiation.


Grade 4 Salivary Gland or Saliva Changes, CTCAE


Myxoid Glioneuronal Tumor of the Septum Pellucidum

A myxoid glioneuronal tumor that arises from the septum pellucidum.


Grade 1 Rectum Stricture or Stenosis, CTCAE


Refractory Bladder Urothelial Carcinoma

Bladder urothelial carcinoma that does not respond to treatment.


Grade 4 Pulmonary Fibrosis Radiographic Changes, CTCAE


Grade 4 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


Grade 2 Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


Idiopathic Cytopenias of Undetermined Significance

Cytopenia in one or more hematopoietic cell lineages that remains unexplained following thorough evaluation. The hematopoietic cell dysplasia is mild and does not fulfill the criteria for myelodysplastic syndrome, but the cytopenia may be severe. There is no evidence of clonal hematopoiesis or the variant allele frequency (VAF) is less that 2 percent. There is no other evidence of hematologic malignancy. It may progress to an overt myelodysplastic syndrome or other myeloid neoplasms such as acute myeloid leukemia, myeloproliferative neoplasm, or mast cell disorder.


Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Bronchospasm, CTCAE

Death


Refractory Anaplastic Pleomorphic Xanthoastrocytoma

Anaplastic pleomorphic xanthoastrocytoma that is resistant to treatment.


Hodgkin's disease mixed cellularity stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 3 Nose Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Soft Tissue Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Benign squamous cell tumor

A non-metastasizing neoplasm composed of squamous cells. The neoplastic cells do not display malignant features.


Grade 3 Hyponatremia, CTCAE

125-129 mmol/L symptomatic; 120-124 mmol/L regardless of symptoms


Grade 5 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Laryngeal Obstruction, CTCAE

Limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)


Grade 3 Dysphasia, CTCAE

Severe receptive or expressive characteristics; impairing ability to read, write or communicate intelligibly


Grade 2 Dysarthria, CTCAE

Moderate impairment of articulation or slurred speech


Recurrent Appendix Mucinous Adenocarcinoma

The reemergence of appendix mucinous adenocarcinoma after a period of remission.


Grade 5 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Endometriosis of thorax

A condition characterized by the presence of functioning endometrial tissue in the lung, pleura, chest wall, and/or diaphragm.


Micronodular adrenal hyperplasia

Adrenal hyperfunction associated with multiple bilateral adrenal nodules, usually less than one centimeter in diameter.


Grade 5 Hypoparathyroidism, CTCAE

Death


Stage I Acral Lentiginous Melanoma AJCC v7

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Resectable Malignant Mesothelioma

Malignant mesothelioma that is amenable to surgical resection.


Grade 5 Hepatic Failure, CTCAE

Death


Intestinal Metaplasia of Bladder Urothelium


Grade 1 Flashing Lights, CTCAE

Symptomatic but not limiting ADL


Fistula of intestine, excluding rectum and anus

An abnormal connection between the intestine and another epithelial-lined structure, but that does not include the rectum or anus.


Grade 1 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Pancreatic Undifferentiated Carcinoma with Rhabdoid Cells

An undifferentiated carcinoma that arises from the pancreas. It is characterized by the presence of rhabdoid cells.


Stage III Appendix Neuroendocrine Tumor AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm but less than or equal to 4 cm. T3: Tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. T4: Tumor perforating the peritoneum or directly invading other adjacent organs or structures (excluding direct mural extension to adjacent subserosa of adjacent bowel), e.g., abdominal wall and skeletal muscle. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Biliary Tree Common Bile Duct Intra-Operative Injury, CTCAE


Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 5q

A rare acute myeloid leukemia that occurs in childhood and is characterized primarily by deletions of 5q.


Grade 3 Abducens Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Locally Advanced Liver Carcinoma

Liver carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 4 Rectal Obstruction, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Locally Advanced Skin Squamous Cell Carcinoma

A squamous cell carcinoma of the skin that has spread from its original site of growth to nearby tissues or lymph nodes.


Adverse Event Associated with the Gastrointestinal System


Grade 1 Lower Extremity Vein Intra-Operative Injury, CTCAE


endometritis following abortion

Endometritis that develops following an abortion.


Grade 4 Herpes Simplex Reactivation, CTCAE

Life-threatening consequences; urgent intervention indicated


Conjunctival Reactive Lymphoid Hyperplasia

A polyclonal proliferation of lymphoid tissue in the conjunctiva that typically occurs in young adults. It usually presents as a unilateral, red or orange, painless swelling and is probably caused by chronic antigen stimulation. (WHO 2018)


Supratentorial Glioblastoma

A glioblastoma that occurs in the supratentorial region.


Ostomy Site Pain

Pain at the site of an ostomy.


Grade 3 Upper Extremity Artery Injury, CTCAE


Metastatic Malignant Germ Cell Tumor

A malignant germ cell tumor that has spread from its original site of growth to another anatomic site.


Benign vascular neoplasm

A benign neoplasm arising from vascular tissue usually of the skin.  It is characterized by the presence of vascular channel formation and endothelial cells.


Refractory Mixed Phenotype Acute Leukemia

Mixed phenotype acute leukemia that does not respond to treatment.


Gastric Perforation, CTCAE

A disorder characterized by a rupture in the stomach wall.


Grade 2 Colon Stricture or Stenosis, CTCAE


Grade 4 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Anaemias due to disorders of glutathione metabolism

Anemia resulting from an abnormality of glutathione deficiency.


Stage IIB Merkel Cell Carcinoma AJCC v7

Stage IIB includes: T2/T3, cN0, M0.  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Grade 1 Testicular Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Inferior Vena Cava Intra-Operative Injury, CTCAE


Pelvic Cancer

A primary or metastatic malignant neoplasm that affects the organs and structures of the pelvis.


Grade 2 Cecum Intra-Operative Injury, CTCAE


Adult TdT Positive Acute Lymphoblastic Leukemia

TdT positive acute lymphoblastic leukemia that occurs during adulthood.


Stage IVA Hepatocellular Carcinoma AJCC v8

Stage IVA includes: Any T, N1, M0. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Gallbladder Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 2 Leukoencephalopathy, CTCAE

Moderate symptoms; focal T2/FLAIR hyperintensities, involving periventricular white matter extending into centrum semiovale or involving 1/3 to 2/3 of susceptible areas of cerebrum +/- moderate increase in SAS and/or moderate ventriculomegaly


Other Associated with the Heart in General, CTCAE


Grade 5 Neonatal Coagulation Disorder, AE

A coagulation disorder adverse event in a newborn which results in death.


Grade 2 Cecum or Appendix Hemorrhage, CTCAE


KATP-Associated Hyperinsulinism

Hyperinsulinism caused by non-functional beta-cell ATP-sensitive potassium channels due to inactivating mutation(s) in either the ABCC8 or KCNJ11 gene.


Grade 3 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Third Ventricle Germinoma

A germinoma that arises from the third ventricle.


Grade 1 Atrioventricular Block First Degree, CTCAE

Asymptomatic, intervention not indicated


Pulmonary Fibrosis, CTCAE

A disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure.


Stage IIA Fallopian Tube Cancer AJCC v6 and v7

Stage IIA includes: T2a, N0, M0.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Grade 2 Phlebitis Including Superficial Thrombosis, CTCAE


Grade 1 Concentration Impairment, CTCAE

Mild inattention or decreased level of concentration


Radiating Chest Pain Along Anterior Axillary Line

The location of the radiating chest pain is along an imaginary vertical line that descends along the lateral aspect of the chest wall originating from the armpit.


Grade 4 Small Intestine Ulcer, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Urinary Tract Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Liposarcoma recurrent

The reemergence of liposarcoma after a period of remission.


Neoplasm of Uncertain Histogenesis

A benign or malignant, primary or metastatic neoplasm with uncertain histogenesis.


Metaplastic Synovial Cyst

A cyst lined by tissue that resembles synovial villi.


Assault

A physical attack.


Grade 2 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Hypopituitarism, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 1 Lower Extremity Artery Injury, CTCAE


Refractory Fallopian Tube High Grade Serous Adenocarcinoma

Fallopian tube high-grade serous adenocarcinoma that is resistant to treatment.


Paratesticular Squamous Cell Carcinoma

An extremely rare squamous cell carcinoma that arises from the paratesticular structures.


Metastatic Carcinoma in the Liver

A carcinoma that has spread to the liver from another primary anatomic site.  Representative examples include metastatic carcinomas from the colon, breast, and lung.


Grade 4 Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Diffuse Glioneuronal Tumor with Oligodendroglioma-Like Features and Nuclear Clusters

A provisional tumor entity described in the supratentorial brain and characterized by a distinct DNA methylation profile and monosomy of chromosome 14. It is composed of small to medium-sized cells showing perinuclear oligodendroglioma-like haloes, scattered multinucleated cells, and nuclear clusters composed of large pleomorphic nuclei. Most cases have been reported in pediatric patients.


Grade 3 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Vaccination Complication, CTCAE

A disorder that occurs after the injection of a substance with antigenic properties, administered to activate the immune system.


Treatment related acute myeloid leukaemia

An acute myeloid leukemia arising as a result of the mutagenic effect of chemotherapy agents and/or ionizing radiation.  (WHO, 2001)


Grade 3 Bladder Stricture or Stenosis, CTCAE


Grade 1 Gastritis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Transitional cell carcinoma in situ

A lesion in which the surface epithelium of the bladder or the renal pelvis and ureter contains transitional cells which display malignant cytologic characteristics.  There is no evidence of stromal invasion.


Grade 5 Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Upper Airway Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Ann Arbor Stage IV AIDS-Related Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Grade 1 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


Ureteric Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures).


Stage III Ampulla of Vater Neuroendocrine Tumor AJCC v8

Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor invading the visceral peritoneum (serosa) or other organs. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Myasthenia Gravis, CTCAE

A disorder characterized by weakness and rapid fatigue of any of the skeletal muscles.


Tracheal Mucositis, CTCAE

A disorder characterized by an inflammation or ulceration involving the mucous membrane of the trachea.


Psychosis, CTCAE

A disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor.


Grade 1 Creatinine Increased, CTCAE

>ULN-1.5 x ULN


Aggressive Systemic Mastocytosis Associated with Germ Cell Tumor

Aggressive systemic mastocytosis associated with a germ cell tumor.


Grade 4 Stenosis of Gastrointestinal Stoma, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Tinnitus, CTCAE

Moderate symptoms; limiting instrumental ADL


Stage IIIC Appendix Carcinoma AJCC v7

Stage IIIC includes: Any T, N2, M0. N2: Metastasis in four or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Gallbladder Cancer AJCC v6

Stage III includes: (T4, Any N, M0).  T4: Tumor invades main portal vein or hepatic artery or invades multiple extrahepatic organs or structures. (AJCC 6th ed.)


Grade 5 Spermatic Cord Anastomotic Leak, CTCAE

Death


Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8

Stage IIB includes: (T1, N1, M0, Any G); (T3, N0, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Bartholin Gland Hyperplasia

Nodular/lobular proliferation of normal Bartholin gland tissue and ducts.


Refractory Digestive System Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from any part of the digestive system and does not respond to treatment.


Grade 3 Blood Corticotrophin Decreased, CTCAE

Hospitalization indicated


Grade 4 Anemia, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Retinopathy, CTCAE

Asymptomatic; clinical or diagnostic observations only


Grade 5 Encephalopathy, CTCAE

Death


Grade 4 Peripheral Motor Nerve NOS Intra-Operative Injury, CTCAE


Refractory Biliary Tract Carcinoma

Biliary tract carcinoma that is resistant to treatment.


Bigeminy, CTCAE

Premature heartbeats alternating regularly with normal beats. It can be associated with hypoxia, ischemia, acute myocardial infarction, and medication overdose.


Primary Raynaud Phenomenon

Raynaud phenomenon without a known underlying autoimmune disorder.


Gallbladder Mucinous Cystic Neoplasm

An epithelial, usually multiloculated neoplasm arising from the gallbladder. It occurs predominantly in females. Signs and symptoms include abdominal mass, abdominal pain, and jaundice. Morphologically, the cystic spaces are lined by columnar epithelium and contain mucinous or serous fluid.


Advanced Melanoma

Melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Gallbladder Obstruction, CTCAE

Symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated


Grade 4 Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE


Grade 1 Vein NOS Intra-Operative Injury, CTCAE


Prostate Adenocarcinoma without Neuroendocrine Differentiation

A prostate adenocarcinoma characterized by the absence of focal or diffuse neuroendocrine differentiation.


Metastatic Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that has spread to other anatomic sites.


Grade 1 Uterine Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Grade 4 Female Genital Tract Fistula, CTCAE


Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Hypoglycemia, CTCAE

Death


Adenocarcinoma, Oxyphilic

An adenocarcinoma characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast carcinoma, and salivary gland oncocytic carcinoma.


Non-Neoplastic Uveal Disorder

A non-neoplastic disorder that affects the uvea.


Hodgkin's disease mixed cellularity recurrent

The reemergence of mixed cellularity classic Hodgkin lymphoma after a period of remission.


Grade 2 Abdomen Soft Tissue Necrosis, CTCAE


Pancreatic Acinar Cell Neoplasm

An epithelial neoplasm that arises from the exocrine pancreas.  It is characterized by the presence of neoplastic cells that resemble acinar cells and produce pancreatic exocrine enzymes.  The vast majority are carcinomas.


Grade 3 Brachial Plexus Intra-Operative Injury, CTCAE


Grade 2 Colonic Ulcer, CTCAE

Symptomatic; altered GI function


Phantom pain

Painful sensation related to a limb or an organ that is removed from or is not physically part of the body.


Metastatic Infiltrating Bladder Urothelial Carcinoma with Giant Cells

Bladder giant cell variant urothelial carcinoma that has spread to another anatomical site.


Uveal prolapse

The protrusion of uveal tissue through an opening in the sclera.


Unresectable Melanoma

Melanoma which is not amenable to surgical resection.


Grade 1 Cranial Nerve IV Neuropathy, CTCAE


Alcohol-Related Carcinoma

A carcinoma that is caused by alcohol abuse.


Retinoblastoma by AJCC v8 Clinical Stage

A term that refers to the clinical staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition.


Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Visceral edema

Accumulation of an excessive amount of watery fluid in the visceral tissues. Symptoms include abdominal pain, nausea, vomiting, and diarrhea.


Intermediate Grade B-Cell Non-Hodgkin's Lymphoma


Liver and Intrahepatic Bile Duct Non-Epithelial Neoplasm

A benign or malignant non-epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts.  Representative examples of benign non-epithelial neoplasms include hemangioma, angiomyolipoma, and solitary fibrous tumor.  Representative examples of malignant non-epithelial neoplasms include lymphoma, angiosarcoma, and undifferentiated (embryonal) sarcoma.


Grade 1 Vaginal Stenosis and Length, CTCAE


undifferentiated carcinoma of anal canal

A usually aggressive malignant epithelial neoplasm that arises from the anal canal.  It is composed of malignant cells which do not display evidence of glandular or squamous differentiation.


Grade 4 Radiculitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Peripheral Ischemia, CTCAE

Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


Hematuria, CTCAE

A disorder characterized by laboratory test results that indicate blood in the urine.


Female Reproductive System Carcinoma

A malignant neoplasm that arises from the epithelium of any part of the female reproductive system. Representative examples include ovarian carcinoma, cervical carcinoma, and endometrial carcinoma.


Grade 2 Kidney Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Bile Duct Mucinous Cystic Neoplasm with Intermediate Grade Intraepithelial Neoplasia

A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of moderate atypia.


Stage IIA Merkel Cell Carcinoma AJCC v7

Stage IIA includes: T2/T3, pN0, M0.  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  pN0: No regional lymph node metastasis by pathologic examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Pathologic Stage IA Cutaneous Melanoma AJCC v8

Stage IA includes: (T1a, N0, M0); (T1b, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 5 Lymphatic Infection with Unknown Absolute Neutrophil Count, CTCAE


Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Electrocardiogram QT Corrected Interval Prolonged, CTCAE

Average QTc 450-480 ms


Grade 4 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Stage IIB Gallbladder Cancer AJCC v8

Stage IIB includes: T2b, N0, M0. T2b: Tumor invading the perimuscular connective tissue on the hepatic side, with no extension into the liver. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Gastrointestinal Disorders - Other, Specify, CTCAE


Hereditary factor VII deficiency disease

A rare autosomal recessive inherited blood coagulation disorder characterized by deficiency of factor VII, resulting in bleeding.


Neonatal infectious disorder

An infectious disorder that occurs during the neonatal period. Representative examples include streptococcal infection, E.coli infection, and bacterial meningitis.


Grade 4 Hypophosphatemia, CTCAE

Life-threatening consequences


Resectable Glioblastoma

A glioblastoma that is amenable to surgical resection.


Grade 3 Sinus Intra-Operative Injury, CTCAE


Grade 2 Ataxia, CTCAE

Moderate symptoms; limiting instrumental ADL


Locally Advanced Non-Cutaneous Melanoma

Non-cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Endometrial Mucinous Adenocarcinoma, Intestinal-Type

A rare mucinous adenocarcinoma arising from intestinal metaplasia of the endometrium.


Blood Cardiac Troponin T Increased

A laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen.


Dog Bite

A wound received from the teeth of a dog.


Grade 4 Colitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Colon Intra-Operative Injury, CTCAE


Stage I Centroblastic Follicular Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Intraoperative Neurological Injury, CTCAE

A finding of damage to the nervous system during a surgical procedure.


Female Reproductive System Precancerous Condition

A precancerous lesion that arises from the female reproductive system. Representative examples include atypical endometrial hyperplasia, endometrial intraepithelial neoplasia, and cervical intraepithelial neoplasia.


Grade 3 Blood and Lymphatic System Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Primary Bone Hodgkin Lymphoma

An exceedingly rare Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement.


Grade 3 Peristomal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Hearing Patients without Baseline Audiogram and Not Enrolled in a Monitoring Program, CTCAE


Lip Pain

Painful sensation in the lip.


Glaucoma, CTCAE

A disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow.


Arthritis NOS aggravated

Exacerbation of an arthritic condition.


Grade 2 Purpura, CTCAE

Combined area of lesions covering 10-30% BSA; bleeding with trauma


Adult Anaplastic Astrocytoma

An astrocytoma occurring in adults that is characterized by the presence of high mitotic activity, cytologic atypia, and architectural distortion.


Locally Advanced Digestive System Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from any part of the digestive system and has spread to nearby tissues or lymph nodes.


Factor XI Inactivation

Presence of inactivating antibodies to factor XI in the blood.


Grade 5 Hypoalbuminemia, CTCAE

Death


Grade 1 Duodenum Intra-Operative Injury, CTCAE


Extrahepatic Bile Duct Carcinoid Tumor

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the extrahepatic bile ducts. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Vaginal Cancer by AJCC v7 Stage

A term that refers to the staging of vaginal cancer according to the American Joint Committee on Cancer, 7th edition.


Pure Erythroid Leukemia

Acute erythroid leukemia characterized by the presence of immature erythroid cells in the bone marrow (at least 80% of the cellular component), without evidence of a significant myeloblastic cell population present.


Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


H influenze type B Meningitis

Meningitis that is attributed to the bacteria H influenze type B.


Grade 1 Ovary Intra-Operative Injury, CTCAE


Urothelial carcinoma ureter recurrent

Reemergence of ureter urothelial carcinoma after a period of remission.


Grade 1 Thyroid Intra-Operative Injury, CTCAE


Grade 2 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Grade 4 Neonatal Intraventricular Hemorrhage, AE

An adverse event in a newborn characterized by intraventricular hemorrhage with parenchymal venous infarction; resulting in life threatening consequences (e.g. refractory seizures, hypotension, respiratory depression); requiring urgent stabilization or surgical decompression.


Grade 2 Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IA Testicular Cancer AJCC v8

Stage IA includes: pT1, N0, M0, S0. pT1: Testicular cancer which is limited to testis (including rete testis invasion) without lymphovascular invasion. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


Grade 1 Liver Intra-Operative Injury, CTCAE


Stage II Cervical Cancer AJCC v8

Stage II includes: T2, Any N, M0. T2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina. M0: No distant metastasis. (AJCC 8th Ed.)


Rhinocephaly

A congenital anatomic defect characterised by the presence of a proboscis-like nose located above the eyes, which are partially or completely fused.


human anaplasmosis

An infection that is caused by Anaplasma phagocytophilum, which is transmitted to humans by infected ticks; it is characterized by fever, headache, chills, and myalgia.


Grade 5 Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Psychosis, Brief Reactive

A disorder characterized by delusions, hallucinations, disorganized speech, and/or grossly disorganized behavior that resolve within a month.


Grade 4 Upper Respiratory Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage IV Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


Condyloma acuminata of vulva

A benign human papillomavirus-related neoplasm that arises from the vulva. It is characterized by the presence of papillary structures with fibrovascular cores covered by stratified squamous epithelium showing koilocytotic changes.


Upper Aerodigestive Invasive Malignancy

A finding indicating the presence of an invasive upper aerodigestive tract malignancy.


Lugano Classification Stage IIE Adult Lymphoma AJCC v8

Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Grade 5 Thrombotic Microangiopathy, CTCAE


Premature Menopause, CTCAE

A disorder characterized by premature ovarian failure. Symptoms may include hot flashes, night sweats, mood swings, and a decrease in sex drive. Laboratory findings include elevated luteinizing hormone (LH) and follicle-stimulating hormone (FSH.)


Childhood Lymphocyte-Rich Classic Hodgkin Lymphoma

Lymphocyte-rich classic Hodgkin lymphoma occurring in childhood.


Grade 3 Bone Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


High Grade Anal Intraepithelial Neoplasia

Anal canal or perianal skin intraepithelial neoplasia with moderate or severe dysplasia.


Stage 0 Merkel Cell Carcinoma AJCC v7

Stage 0 includes: Tis, N0, M0.  Tis: In situ primary tumor.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Mandibular Buccal Bifurcation Cyst

An inflammatory collateral cyst that arises on the lower first or second molars. (WHO 2017)


Grade 3 Corneal Ulcer, CTCAE

Corneal ulcer without perforation in the affected eye


Grade 1 Cataract, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Sleep Apnea, CTCAE

A disorder characterized by cessation of breathing for short periods during sleep.


Grade 5 Cranial Nerve II Neuropathy, CTCAE


Recurrent Biliary Tract Carcinoma

The reemergence of a carcinoma arising from any part of the biliary tract after a period of remission.


Gallbladder Flat Biliary Intraepithelial Neoplasia

Biliary intraepithelial neoplasia that affects the gallbladder epithelium.  It is characterized by the absence of intraluminal micropapillary projections.


Midgut Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the jejunum, ileum, proximal colon, or appendix. The Ki-67 index is higher than 20%.


Grade 2 Fibrosis-Deep Connective Tissue, CTCAE


Grade 2 Laryngeal Obstruction, CTCAE

Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


Chronic Bullous Disease of Childhood

A blistering disorder characterized by linear deposition of IgA at the dermoepidermal junction.


Grade 2 Prolapse of Urostomy, CTCAE

Local care or maintenance; minor revision indicated


Grade 5 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Vaginal Cancer by AJCC v6 Stage

A term that refers to the staging of vaginal cancer according to the American Joint Committee on Cancer, 6th edition.


Therapy-Related Cytogenetically Normal Acute Myeloid Leukemia

Acute myeloid leukemia not associated with cytogenetic abnormalities and arising as a result of the mutagenic effect of chemotherapy and/or ionizing radiation.


Grade 4 Ileal Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Laryngeal Inflammation, CTCAE

A disorder characterized by an inflammation involving the larynx.


Grade 5 Persistent Pulmonary Hypertension of the Newborn, AE

A persistent pulmonary hypertension adverse event in a newborn which results in death.


Childhood Grade II Meningioma

A grade II meningioma that occurs during childhood.


Periosteal Desmoid Tumor

A reactive, benign fibrous lesion that develops in the periosteum of the femur.  It usually affects boys and there is a history of trauma.  It is characterized by the formation of dense collagen tissue and reactive bone.


Stage IIB Testicular Cancer AJCC v8

Stage IIB includes: (Any pT/TX, N2, M0, S0); (Any pT/TX, N2, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Bacterial Zoonoses

A bacterial infection that is transmitted from animals to people.


Grade 3 Neck NOS Intra-Operative Injury, CTCAE


Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Lymph Leakage, CTCAE

A disorder characterized by the loss of lymph fluid into the surrounding tissue or body cavity.


Mucosal Melanoma of the Genitourinary System

A malignant melanocytic neoplasm that arises from a mucosal site of the genitourinary system.


Grade 5 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Biliary Tree Stricture or Stenosis, CTCAE


Bladder Spasm, CTCAE 5.0

A disorder characterized by a sudden and involuntary contraction of the bladder wall.


Grade 1 Dyspareunia, CTCAE

Mild discomfort or pain associated with vaginal penetration; discomfort relieved with use of vaginal lubricants or estrogen


Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome

An acute myeloid leukemia developing in patients with a prior history of myelodysplastic syndrome.


Refractory Malignant Mastocytosis

Malignant mastocytosis that is resistant to treatment.


Recurrent Ependymoma

The reemergence of ependymoma after a period of remission.


Malposition of Ureter

Orientation of a ureter in an unusual anatomic location.


Grade 1 Allergic Rhinitis Including Sneezing Nasal Stuffiness Postnasal Drip, CTCAE


Grade 4 Esophagus Intra-Operative Injury, CTCAE


Glioblastoma with Primitive Neuronal Component

A glioblastoma characterized by the presence of well-demarcated nodules which contain primitive cells exhibiting neuronal differentiation.


Grade 4 Toxic Epidermal Necrolysis, CTCAE

Skin sloughing covering >=30% BSA with associated symptoms (e.g., erythema, purpura, or epidermal detachment)


Congenital Phrenic Nerve Palsy

Damage to the phrenic nerve that results in paralysis of the hemidiaphragm at birth.


Stage III Prostate Cancer AJCC v7

Stage III includes: T3a-b, N0, M0, Any PSA, Any Gleason.  cT3a: Tumor with extracapsular extension (unilateral or bilateral).  pT3a: Tumor with extraprostatic extension or microscopic invasion of bladder neck.  T3b: Tumor invades seminal vesicle(s).  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Small Cell Glioblastoma

A small cell glioblastoma that is resistant to treatment.


FIGO Stage IC Gestational Trophoblastic Tumor


Stage IA Cervical Cancer AJCC v8

Stage IA includes: T1a, Any N, M0. T1a: Tumor diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IVB Bladder Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Non-lymph node distant metastases. (AJCC 8th ed.)


Musculoskeletal Chest Pain due to Slipping Rib Syndrome

A condition in which there is musculoskeletal chest pain associated with one or more ribs subluxing from the joint. (ACC/AHA)


Genetic anomaly of leukocyte

An abnormality of leukocytes, the cause of which is present from birth.


Weight Gain Due to Fluid Retention

A finding of rapid weight gain due to fluid retention.


Necrotizing granulomatous inflammation

A granuloma that contains areas of necrosis.  The majority of cases are of infectious origin.


Grade 3 Gastric Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Delirium, CTCAE

A disorder characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Usually, it is a reversible condition.


Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Partial Thromboplastin Time, CTCAE


Squamous cell papilloma of eyelid

A papilloma that arises from the eyelid. It is composed of squamous cells and is characterized by the presence of an acanthotic epithelium with hyperkeratosis and papillary projections with an inner fibrovascular core. It is the most common benign epithelial tumor of eyelid. It usually affects middle-aged or older adults.


Stomach Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Metabolic or Respiratory Acidosis, CTCAE


Forced Expiratory Volume Decreased, CTCAE

A finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds.


Ureter Cancer by AJCC v8 Stage

A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. (from AJCC 8th Ed.)


Lymphoma by Working Formulation (Antiquated)


Grade 4 Alanine Aminotransferase Increased, CTCAE

>20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal


Childhood Acute Leukemia

An acute leukemia that occurs during childhood.


Gastric Poorly Cohesive Adenocarcinoma

An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.  This category includes signet ring cell adenocarcinomas, adenocarcinomas that are composed of malignant cells resembling lymphocytes and histiocytes, and adenocarcinomas that are composed of malignant cells with deeply eosinophilic cytoplasm.


Grade 1 Photosensitivity, CTCAE

Painless erythema and erythema covering <10% BSA


Stage IIIA Gastric Carcinoma

Stage IIIA includes: (T4a, N1, M0); (T3, N2, M0); (T2, N3, M0).  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Periventricular Leukomalacia, AE

An adverse event in a newborn characterized by a form of cerebral white matter injury usually seen in preterm infants that is characterized by necrotic degeneration or gliosis of white matter adjacent to the cerebral ventricles that may evolve into focal cysts.


Expected Adverse Event

Any adverse event associated with a medical product or procedure, whose nature and severity have been previously observed, identified in nature, severity, or frequency, and documented in the investigator brochure, investigational plan, protocol, current consent form, scientific publication, or in other relevant and reliable document. The old term Side Effect is retired and should not be used.


Grade 3 Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Irritability, CTCAE

A disorder characterized by an abnormal responsiveness to stimuli or physiological arousal; may be in response to pain, fright, a drug, an emotional situation or a medical condition.


Grade 3 Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


Grade 5 Pulmonary Fibrosis, CTCAE

Death


Stage IIIC1 Cervical Cancer AJCC v9

Stage IIIC1 includes: TX, T0, T1-3, N1, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage III Bone Sarcoma AJCC v7

Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 3 Spinal Cord Intra-Operative Injury, CTCAE


Grade 2 Chest Pain - Cardiac, CTCAE

Moderate pain; pain on exertion; limiting instrumental ADL; hemodynamically stable


Mitochondrial enzyme deficiency

A constellation of disorders whose common thread is the insufficient quantity of one or more mitochondrial enzymes.


Grade 2 Ear Pain, CTCAE

Moderate pain; limiting instrumental ADL


Low Grade Lymphoma (neoplasm)

An antiquated term that refers to a non-Hodgkin lymphoma with low grade histologic features.


Grade 2 Infertility and Sterility, CTCAE


Grade 3 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 2 Central Nervous System Necrosis, CTCAE

Moderate symptoms; corticosteroids indicated