epidermodysplasia verruciformis

A rare inherited genodermatosis characterized by chronic infection with human papillomavirus (HPV) leading to polymorphous cutaneous lesions and high risk of developing non melanoma skin cancer.


Brain Contusion

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Metastasis from malignant neoplasm of colon and/or rectum


systemic mycosis

A mycosis that involves the lungs, abdominal viscera, bones and or central nervous system.


Impaired self-care

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Detachment of retinal pigment epithelium


Small intestinal bleeding

Bleeding from the small intestine.


Bilateral Deafness

Partial or total inability to hear sounds in both ears.


chronic urticaria

An urticaria that is characterized by the presence of urticaria for a period exceeding 6 weeks, assuming symptoms for most days of the week.


acquired Fanconi syndrome

Fanconi Syndrome caused by exposure to noxious agents.


Comminuted Fracture type

A type of fracture in which the break is in three or more pieces and fragments are present at the fracture site.


Hypoplasia of the thymus

Underdevelopment of the thymus.


chronic eosinophilic pneumonia

Chronic inflammatory disorder of the lungs characterized by the presence of eosinophils in the interalveolar septa and alveolar spaces and peripheral blood eosinophilia. Chest x-rays reveal peripheral infiltrates. Approximately half of the patients have history of asthma or atopic disease. Signs and symptoms include fever, dyspnea, cough, and weight loss. Following treatment with corticosteroids, the eosinophilic infiltrates in the lungs disappear, resulting in dramatic clinical improvement.


Organ Failure

The failure of an essential system in the body.


Leukemic infiltration of skin

Cutaneous involvement by an acute or chronic leukemia.


Delusional disorder, persecutory type

A subtype of delusional disorder characterized by the central delusional theme that the individual is being malevolently treated (for example, maligned, harassed, conspired against, poisoned or drugged) by another person or group.


Difficulty walking

Reduced ability to walk (ambulate).


Fracture with displacement

A type of fracture in which the ends of the fractured bone are no longer aligned.


non-alcoholic steatohepatitis

Fatty replacement and damage to the hepatocytes not related to alcohol use. It may lead to cirrhosis and liver failure.


chronic progressive multiple sclerosis

A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)


Clonic seizure

A clonic seizure is a type of motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive.


trichosporonosis

Fungal infections caused by trichosporon that may become systemic especially in an immunocompromised host. Clinical manifestations range from superficial cutaneous infections to systemic lesions in multiple organs.


Traumatic hemorrhage

Vascular rupture, and the resulting loss of blood, due to physical injury.


Disorder of tonsil (palatine tonsil)

A non-neoplastic or neoplastic disorder that affects the tonsils.


Bronchopleural Fistula

An abnormal communication between a bronchus and the pleural cavity.


Allodynia

Pain due to a stimulus that does not normally provoke pain.


Human immunodeficiency virus transmission


Protein/Creatinine ratio in urine above normal


Urine albumin/creatinine ratio increased


tuberculous peritonitis

A form of peritonitis seen in patients with tuberculosis, characterized by lesion either as a miliary form or as a pelvic mass on the peritoneal surfaces. Most patients have ascites, abdominal swelling, abdominal pain, and other systemic symptoms such as fever; weight loss; and anemia.


type IV hypersensitivity disease

A disease that has its basis in the disruption of type IV hypersensitivity.


Thermal burn

A burn injury caused by heat or fire.


neurodegenerative disease

A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function.


Iris transillumination defect

Transmission of light through the iris as visualized upon slit lamp examination or infrared iris transillumination videography. The light passes through defects in the pigmentation of the iris.


Wound Complication

A medical condition that develops at the site of an existing wound. Examples include swelling, draining, bleeding, formation of hematoma, infection, and necrosis.


benign fibrous histiocytoma

A benign neoplasm composed of fibroblastic spindle cells in a whorled storiform pattern. It is characterized by the presence of foam cells, inflammatory cells, hemosiderin deposition and stromal hemorrhage.


acquired hemophilia

Acquired hemophilia is a bleeding disorder that interferes with the body's blood clotting process. Signs and symptoms include prolonged bleeding, frequent nosebleeds, bruising throughout the body, solid swellings of congealed blood (hematomas), hematuria, and gastrointestinal or urologic bleeding. Acquired hemophilia occurs when the body's immune system attacks and disables a certain protein that helps the blood clot. About half of the cases are associated with other conditions, such as pregnancy, autoimmune disease, cancer, skin diseases, or allergic reactions to medications.


Thymalfasin

A thymus hormone polypeptide found in thymosin fraction 5 (a crude thymus gland extract) but now produced by synthesis. It is used alone or with interferon as an immunomodulator for the treatment of CHRONIC HEPATITIS B and HEPATITIS C. Thymalfasin is also used for the treatment of chemotherapy-induced immunosuppression, and to enhance the efficacy of influenza and hepatitis B vaccines in immunocompromised patients.


Anterior chamber cells

Tiny deposits corresponding to cells floating in the anterior chamber of the eye. This appearance is typically associated with intraocular inflammation leading to breakdown of the blood-aqueous barrier and resulting in an increase in the number of cells and in the aqueous humor. Grading (SUN Working Group) is performed by estimating the number of cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.


trisomy 18

Trisomy 18 is a chromosomal abnormality associated with the presence of an extra chromosome 18 and characterized by growth delay, dolichocephaly, a characteristic facies, limb anomalies and visceral malformations.


Increased RBC distribution width

Red blood cell distribution width (RDW) is a simple parameter of the standard full blood count and a measure of heterogeneity in the size of circulating erythrocytes. It is provided by automated hematology analyzers and it reflects the range of the red cell size. It is calculated by dividing the standard deviation of erythrocyte volume by the mean corpuscular volume (MCV) and multiplied by 100 to convert to a percentage.


microsporidiosis

A fungal infection caused by Microsporidia. It occurs in immunocompromised patients, causing diarrhea and wasting.


Progesterone Receptor Positive

An indication that progesterone receptor (PRG; PR) expression has been detected in a sample.


Nodule

A small lump, swelling or collection of tissue.


small intestine carcinoma

A carcinoma that arises from epithelial cells of the small intestine


Labile affect

Emotional instability characterized by rapid and dramatic mood swings. (ACC/AHA)


Helicobacter pylori infectious disease

Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.


Increased viscosity of bronchial secretion


Skin Burning Sensation

A sensation of dermal stinging or heat, not necessarily accompanied by redness or physical signs of skin irritation.


Anticonvulsant drug level above therapeutic


Atresia of the external auditory canal

Absence or failure to form of the external auditory canal.


Metaplasia

Transformation of a mature, normal cell or groups of mature cells to other forms of mature cells.  The capacity for malignant transformation of metaplastic cells is a subject of controversy.


Intervertebral space narrowing

Decreased height of the intervertebral disk.


Increased mean platelet volume

Average platelet volume above the upper limit of the normal reference interval.


Decreased mean platelet volume

Average platelet volume below the lower limit of the normal reference interval.


Neutropenia in presence of anti-neutropil antibodies

A type of neutropenia that is observed in the presence of granulocyte-specific antibodies.


Free thyroxine concentration decreased below normal


Free thyroxine concentration increased above normal


hypertensive nephropathy

Kidney damage that results from chronically elevated blood pressure; complications include glomerular damage resulting in proteinuria and hematuria.


BK virus infection

An infection caused by the BK virus. It usually causes an asymptomatic infection, except in immunocompromised individuals where it may cause nephropathy or hemorrhagic cystitis.


Retinal neovascularization

In wound repair, neovascularization (NV) involves the sprouting of new vessels from pre-existent vessels to repair or replace damaged vessels. In the retina, NV is a response to ischemia. The NV adheres to the inner surface of the retina and outer surface of the vitreous. NV are deficient in tight junctions and hence leak plasma into surrounding tissue including the vitreous. Plasma causes the vitreous gel to degenerate, contract, and eventually collapse which pulls on the retina. Since retinal NV is adherent to both retina and vitreous, as the vitreous contracts the NV may be sheared resulting in vitreous hemorrhage or the NV may remain intact and pull the retina with the vitreous resulting in retinal elevation referred to as traction retinal detachment.


Hemorrhage urinary tract

Bleeding originating from any part of the urinary system.


Postmenopausal bleeding

Uterine bleeding that occurs after at least one year of amenorrhea in a woman who is not receiving hormone therapy.


Intramuscular hematoma

Blood clot formed within muscle tissue following leakage of blood into the tissue.


Bilateral tonic-clonic seizure with focal onset

A bilateral tonic-clonic seizure with focal onset is a focal-onset seizure which progresses into a bilateral tonic-clonic phase.


adenomyosis

The growth of endometrial tissue inside the muscular wall of the uterine corpus. Clinical manifestations include pain, dysmenorrhea, and menorrhagia.


Anticonvulsant drug level below therapeutic


synovial bursa disorder

A disease or disorder that involves the synovial bursa.


Pulmonary mass

A mass in the lung seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics).


Bone Tuberculosis

Tuberculosis of the bone.


oppositional defiant disorder

A behavior disorder characterized by a persistent pattern of defiant, disobedient, and hostile behavior towards authority figures, manifested by a frequent loss of temper, arguing, becoming angry or vindictive, or other negativistic behaviors.


Preexisting Condition

A health condition or medical problem that was diagnosed or treated before a specific date.


coronary restenosis

Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.


cutaneous lupus erythematosus

An autoimmune disorder that manifests as different lupus-specific skin disorders; it can occur with systemic lupus erythematosus, or as a singular disease.


geotrichosis

Infection due to the fungus Geotrichum.


Gastric infection

An acute or chronic infectious process affecting the stomach.


de Quervain disease

Stenosing tenosynovitis of the abductor pollicis longus and extensor pollicis brevis tendons in the first dorsal wrist compartment. The presenting symptoms are usually pain and tenderness at the radial styloid. The cause is almost always related to overuse injury or is associated with rheumatoid arthritis.


Below Normal Body Height

Body height below the normal range.


stomach disorder

A disease involving the stomach.


Infective exacerbation of chronic obstructive airways disease


microscopic colitis

Inflammation of the colon that is only apparent by microscopic examination.


Palatal edema

Swelling related to fluid accumulation within the palate.


Pneumatosis intestinalis

The presence of gas within the wall of the large or small intestine.


Tenesmus

A repeated, painful urge to defecate without excreting stool.


Gastrointestinal tract mucosal discoloration


Blast Cells Present

A laboratory test result indicating the presence of blast cells in a blood sample.


Hepatic Mass

A space-occupying pathologic process that affects the liver parenchyma.


Abnormal urinary odor

A deviation from the normal odor of the urine.


ciliary body disorder

A disease involving the ciliary body.


chronic liver failure

Liver failure that develops slowly and gradually for some time, possibly for years, often as the result of cirrhosis, or malnutrition.


Abnormal ventricular axis

Any deviation from the normal direction of the ventricular axis. The left ventricle makes up most of the heart muscle under normal circumstances and therefore generates the most electrical force visible on the EKG. The normal ventricular axis is directed downward and slightly towards the left. The ventricular axis can be determined by analyzing the QRS complex, which represents ventricular depolarization.


chronic inflammatory demyelinating polyradiculoneuropathy

A rare neurological disorder in which there is inflammation of nerve roots and peripheral nerves and destruction of the fatty protective covering (myelin sheath) over the nerves. This affects how fast the nerve signals are transmitted and leads to loss of nerve fibers. This causes weakness, paralysis and/or impairment in motor function, especially of the arms and legs (limbs). Sensory disturbance may also be present. The motor and sensory impairments usually affect both sides of the body (symmetrical), and the degree of severity and the course of disease may vary from case to case. Some affected individuals may follow a slow steady pattern of symptoms while others may have symptoms that stabilize and then relapse.


vascular dementia

A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.


Bloody Discharge

The leaking of serosanguinous fluids from an orifice or wound.


cerebral toxoplasmosis

Infections of the brain caused by the protozoan toxoplasma gondii that primarily arise in individuals with immunologic deficiency syndromes (see also aids-related opportunistic infections). The infection may involve the brain diffusely or form discrete abscesses. Clinical manifestations include seizures, altered mentation, headache, focal neurologic deficits, and intracranial hypertension. (From Joynt, Clinical Neurology, 1998, Ch27, pp41-3)


Hypertelorism

Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes).


Increased Bone Density

A finding indicating an increased density of minerals in the bones. Causes include osteopetrosis and Paget disease.


Prostate specific antigen outside reference range


Cancer-Associated Pain

Pain associated with cancer or its diagnosis or treatment.


metabolic disease

A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.


Neutrophilic dermatosis

A type of dermatosis characterized by dense infiltration of neutrophils in the skin without evidence of infection or vasculitis. It may be secondary to an underlying systemic illness.


Electromechanical dissociation

An electrocardiographic finding of the presence of cardiac electrical rhythm without a proper response of the myocardial tissue and mechanical cardiac output.


Clostridium colitis

An acute inflammatory disorder of the colon secondary to infection with any species of the bacterial genus Clostridium. Symptoms include acute diarrhea, abdominal pain, and myalgia.


Dysplasia

A usually neoplastic transformation of the cell, associated with altered architectural tissue patterns. The cellular changes include nuclear and cytoplasmic abnormalities. Molecular genetic abnormalities are also often found and, in some instances, may lead to cancer.


Electrocardiogram signs of myocardial ischemia


Parakeratosis

Abnormal formation of the keratinocytes of the epidermis characterized by persistence of nuclei, incomplete formation of keratin, and moistness and swelling of the keratinocytes.


agraphia

An acquired writing disorder causing a loss in the ability to communicate through writing, either due to some motor dysfunction or the inability to spell.


hypogonadism

A disorder characterized by decreased function of the gonads. Clinical manifestations in both males and females include poor libido, infertility, and osteoporosis. Additional signs in males include erectile dysfunction, muscle atrophy, gynecomastia and increased abdominal fat. In females, additional signs include shrinking of the breasts and loss of, or failure to develop menstruation.


Limitation of neck motion

Limited mobility of the neck, usually accompanied by pain.


serositis

Inflammation of a serous membrane.


Hypoperfusion

No component of the tumor exhibits perfusion equal to or greater than cerebellar gray matter, excluding encased or grossly visible intrinsic vasculature.


Right Ventricular Dysfunction

Impairment of the right ventricular function associated with low ejection fraction and decreased motility of the right ventricular wall.


Cranial Suture Separation

A finding of increased space between the intersections of a newborn's cranial bones.


Poor Sucking Reflex

Uncoordinated or ineffective drawing of saliva or breast milk by a newborn infant.


Clinodactyly

An angulation of a digit at an interphalangeal joint in the plane of the palm (finger) or sole (toe).


Chronic lymphocytic leukemia transformation


Esophageal Infection

An infectious process affecting the esophagus.


mycobacterium avium complex disease

An infection that is caused by Mycobacterium avium.


Reactivation of hepatitis B viral hepatitis


Infectious Enterocolitis

An infectious process affecting the small and large intestines. Symptoms include diarrhea, cramping abdominal pain, and fever.


Viremia

The presence of virus in the blood.


Pseudoseizure

Sudden, involuntary seizure-like attacks that, unlike epileptic seizures, are not related to electrographic ictal discharges.


Neuropathic spinal arthropathy

A progressive disorder of vertebral joint degeneration that occurs in the setting of any condition characterized by decreased afferent innervation, involving loss of deep pain and proprioceptive sensation in the vertebral column. Patients most commonly present with symptoms of lower back pain, sitting imbalance, progressive spinal deformity (usually kyphosis), and an audible clicking sound on changing postures.


Thalamic hemorrhage

Bleeding in the thalamus.


Hemobilia

Bleeding into the biliary tree.


Venous occlusion

Blockage of venous return (flow of blood from the periphery back towards the right atrium) in a vein.


Brow ptosis

Drooping of the upper eyebrow below the superior orbital rim.


Intestinal Mass

An abnormal growth in the small or large intestine.


Gastrointestinal toxicity

Toxicity that impairs or damages the gastrointestinal system.


Brugada syndrome

A genetically heterogeneous condition characterized by complete or incomplete right bundle branch block accompanied by ST elevation in leads V1-V3. There is a high incidence of ventricular arrhythmia that may result in sudden death.


Recurrent Acute Myeloid Leukemia

The reemergence of acute myeloid leukemia after a period of remission.


Reactive hypoglycemia

Hypoglycermia following a meal (or more generally, after intake of glucose).


Ventricular Dysfunction

Impairment of the ventricle to either fill or eject adequately.


blue toe syndrome

A condition that is caused by recurring atheroembolism in the lower extremities. It is characterized by cyanotic discoloration of the toes, usually the first, fourth, and fifth toes. Discoloration may extend to the lateral aspect of the foot. Despite the gangrene-like appearance, blue toes may respond to conservative therapy without amputation.


Intestinal bleeding

Bleeding from the intestines.


Early satiety

The condition of being unable to eat a full meal because of a feeling of fullness (satiety), or or feeling very full after eating only a small amount of food.


acute hepatitis B virus infection

A new infection by the hepatitis B virus, which can be transmitted by direct contact of infected blood with mucous membranes or open areas of the skin. Signs and symptoms may include loss of appetite, joint and muscle pain, low-grade fever and stomach pain. Two to six percent of adults progress to a chronic infection, while 90% of infants become chronically ill. A vaccine is available for those at risk.


CNS metastases

A malignant neoplasm that has spread to the central nervous system from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas).


Small intestine carcinoma stage IV

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


familial caudal dysgenesis

Familial caudal dysgenesis is a rare, genetic, developmental defect during embryogenesis disorder characterized by varying degrees of caudal dysgenesis, ranging from a single umbilical artery or imperforate anus to full sirenomelia, in several members of the same family. Phenotype includes lumbosacral agenesis, anal atresia or ectopia, genitourinary abnormalities, components of VATER or VACTERL association, and facial dysmorphism (flat facies, abnormal ears, bilateral epicanthic folds, depressed nasal bridge, micrognathia). Additional features reported include cardiovascular (e.g. endocardial cushion defect, hypoplasia of pulmonary artery) and skeletal (kyphosis, hemipelvis) anomalies.


Lung hyperinflation

Abnormal permanent enlargement of the lung air spaces distal to terminal bronchiole not resulted from wall destruction, e.g. due to loss of opposite lung.


Blood Alkaline Phosphatase Increased

A laboratory test result which indicates an increased level of alkaline phosphatase in a biological specimen.


Ureaplasma urethritis

Infections with bacteria of the genus ureaplasma.


Tissue Adhesion

A fibrous band of tissue that connects normally separate body regions.


Decreased urine output

A decreased rate of urine production.


Antinuclear antibody positivity

The presence of autoantibodies in the serum that react against nuclei or nuclear components.


Antipsychotic drug level above therapeutic


Antipsychotic drug level below therapeutic


Right ventricular systolic pressure increased


Anticoagulation drug level above therapeutic


Anticoagulation drug level below therapeutic


Diskitis

Inflammation of an intervertebral disc or disk space.


hyperlipoproteinemia type V

A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma chylomicrons and triglycerides contained in very-low-density lipoproteins. Type V hyperlipoproteinemia is often associated with diabetes mellitus and is not caused by reduced lipoprotein lipase activity as in hyperlipoproteinemia type I.


Hemorrhagic ovarian cyst

An abdominal mass formed by bleeding into a follicular ovarian cyst or corpus luteum cyst.


choroidal neovascularization

An eye disorder described by the growth of new blood vessels that originate from the choroid through a break in the Bruch membrane into the sub–retinal pigment epithelium (sub-RPE) or subretinal space. Choroidal neovascularization (CNV) is a major cause of visual loss.


Neurological Signs and Symptoms

A term that refers to the clinical manifestations resulting from pathologic processes that affect the central and peripheral nervous system.


Graft failure

Failure of transplanted tissue to become functional or operational, often as a result of destruction by the host's immune system.


monoclonal gammopathy

A condition characterized by the abnormal presence of monoclonal immunoglobulins in the blood or urine.


Adverse event

Any unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure. Such events can be related to the intervention, dose, route of administration, patient, or caused by an interaction with another drug(s) or procedure(s).


Diffuse alveolar damage

Diffuse alveolar damage (DAD) describes a comon histologic injury pattern of the lung. The early stages are characterized by epithelial cell necrosis and sloughing, fibrous exsudate, edema, and hyaline membranes made of surfactant and proteins, filling the alveoli. This results in impaired gas exchange. In later stages, type II cells and myofibroblasts proliferate within the interstitium and airspaces. The corresponding clinical entity is acute respiratory distress syndrome (ARDS). DAD may result from pulmonary drug toxicity, occurs in immunosuppressed, severe viral infections, acute interstial pneumonitis and crack cocaine inhalation.


adenoviridae infectious disease

An infectious process caused by adenovirus. The virus may cause respiratory illness, conjunctivitis, gastroenteritis, and cystitis.


amnionitis

Inflammation of the amnion.


disorder of appendix

A disease or disorder that involves the vermiform appendix.


arterial disorder

An impairment of the structure or function of the blood vessels which carry blood away from the heart.


Arterial stenosis

Narrowing or constriction of the inner surface (lumen) of an artery.


Abnormal sputum

Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin.


benign neoplasm

A neoplasm which is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign neoplasms remain confined to the original site of growth and do not metastasize to other anatomic sites.


urinary bladder disorder

A disease involving the urinary bladder.


male breast carcinoma

A malignant neoplasm involving the male breast.


breast disorder

A disease involving the breast.


Clostridium infectious disease

Infections with bacteria of the genus clostridium.


colonic neoplasm

A benign or malignant neoplasm that affects the colon. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colonic adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms.


communication disorder

A disorder characterized by an individual's inability to comprehend or share ideas or feelings because of an impairment in language, speech, or hearing.


Obstetric Labor Complications

Any unintended event during the labor process that makes delivery more difficult.


congenital anomaly of cardiovascular system

A disease that has its basis in the disruption of cardiovascular system development.


Abnormality of the mouth

An abnormality of the mouth.


cranial nerve neuropathy

A neoplastic or non-neoplastic disorder that affects one of the cranial nerves.


diaphragm disorder

A disease involving the diaphragm.


Abnormal eosinophil count

Any deviation from the normal number of eosinophils per volume in the blood circulation.


Eye Injuries

Damage to the eye.


eyelid disorder

A disease involving the eyelid.


Congenital anomaly of eyelid

The abnormal formation of the eyelid that is present at the time of birth.


Fistula of the female genital organs

An abnormal communication between a female reproductive system organ and another organ or cavity.


Deviation of finger

Deviated fingers is a term that should be used if one or more fingers of the hand are deviated from their normal position, either to the radial or ulnar side. A deviation of a finger can be caused by an abnormal form of one or more of the phalanges of the affected finger, or by a deviation or displacement of one or more phalanges.


Fetal Diseases

A non-neoplastic or neoplastic disorder which occurs in the fetus.


Abnormal foot morphology

An abnormality of the skeleton of foot.


Fracture of pelvis

A traumatic break in one or more of the bones that compose the bony structure of the pelvis.


Injury of gastrointestinal tract

Trauma to the gastrointestinal tract or accessory organs of digestions.


haemophilus infectious disease

Infections with bacteria of the genus haemophilus.


Abnormality of the hand

An abnormality affecting one or both hands.


impulse control disorder

A category of behaviors that can be loosely defined as the failure to resist an impulsive act or behavior that may be harmful to self or others.


Inflammation

A finding of a localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation.


ligament disorder

A disease or disorder that involves the ligament.


Limb injury

Trauma to an arm or leg.


lymphoproliferative syndrome

A disorder characterized by proliferation of lymphocytes at various stages of differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis).


nutritional disorder

Any condition related to a disturbance between proper intake and utilization of nourishment.


iris disorder

A disease involving the iris.


ischemic disease

Lack of blood supply to an area of the body, resulting in impairment of tissue oxygenation.


laryngeal disorder

A non-neoplastic or neoplastic disorder that affects the larynx. Representative examples include laryngitis, vocal cord polyp, squamous papilloma, and carcinoma.


legionellosis

Any disease caused by Legionella bacteria.


mantle cell lymphoma

Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''.


psychiatric disorder

A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia.


metastatic neoplasm

A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site. Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology.


Motor Deficit

Loss of movement function.


nail infection

An infectious process affecting the nail.


Abnormality of the neck

An abnormality of the neck.


Abnormal neutrophil count

A deviation from the normal range of neutrophil cell counts in the circulation.


toxic or nutritional optic neuropathy

A disease with basis in optic nerve damage secondary to a toxic substance and/or nutritional deficiency.


human papilloma virus infection

An infectious process caused by a human papillomavirus. This infection can cause abnormal tissue growth.


Focal-onset seizure

A focal-onset seizure is a type of seizure originating within networks limited to one hemisphere. They may be discretely localized or more widely distributed, and may originate in subcortical structures.


pericardium disorder

A disease involving the pericardium.


Peritoneal Diseases

A non-neoplastic or neoplastic disorder that affects the peritoneum.  Representative examples of non-neoplastic disorders include peritonitis and panniculitis.  Representative examples of neoplastic disorders include adenomatoid tumor, primary peritoneal carcinoma, metastatic carcinoma to the peritoneum, and malignant mesothelioma.


pleural neoplasm

A benign or malignant neoplasm that involves the serous membrane that lines the lungs and thoracic cavity. Most pleural neoplasms are metastatic. Diffuse malignant mesothelioma is the most common primary malignant neoplasm of the pleura.


poisoning

A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.


Injury of integument

Damage to the skin.


Fractured skull

A partial or complete breakage of the skull.


Disorder of soft tissue

A non-neoplastic or neoplastic disorder that affects the soft tissue.


vertebral column disorder

A disease involving the vertebral column.


spondylitis

The inflammation of a vertebra.


sudden sensorineural hearing loss

Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning.


synovium disorder

A disease or disorder that involves the layer of synovial tissue.


Thoracic Injuries

Trauma to the chest.


gastrointestinal tuberculosis

Tuberculosis that involves any region of the gastrointestinal tract, mostly in the distal ileum and the cecum. In most cases, mycobacterium tuberculosis is the pathogen. Clinical features include abdominal pain; fever; and palpable mass in the ileocecal area.


Upper Extremity Fracture

A traumatic break in one or more of the bones in the arm,  forearm, or hand.


vaginal disorder

A non-neoplastic or neoplastic disorder that affects the vagina. Representative examples include vaginal infection, vaginal polyp, and vaginal squamous cell carcinoma.


leukocyte disorder

A disease involving leukocytes.


anal carcinoma

A carcinoma that arises from epithelial cells of the anus


Poor appetite

A reduced desire to eat.


Cerebral cyst

A fluid filled sac within the cerebrum. It is can be congenital, trauma related or secondary to another medical condition for example an infarction.


colorectal carcinoma

A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas.


Proteus infectious disease

Infections with bacteria of the genus proteus.


Pseudomonas infection

Infections with bacteria of the genus pseudomonas.


Pulmonary vascular disorder

A category of non-neoplastic disorders that affect the blood vessels in the lungs.  Representative examples include pulmonary embolism, pulmonary hypertension, and arteriovenous malformations.


Renal function tests outside reference range


Injury of kidney

Trauma to the kidney.


kidney neoplasm

A benign or malignant neoplasm affecting the kidney. Representative examples of benign renal neoplasms include fibroma, lipoma, oncocytoma, and juxtaglomerular cell tumor. Representative examples of malignant renal neoplasms include renal cell carcinoma, renal pelvis carcinoma, Wilms tumor, rhabdoid tumor, sarcoma, and lymphoma.


Neonatal respiratory system disorder

A respiratory system disorder that occurs during the neonatal period. A representative example is the respiratory distress syndrome.


Rhinovirus infection

An infectious process caused by rhinovirus. The virus usually causes upper respiratory infections, but can infect the lower tract as well.


lumbar disc degenerative disorder

Any degenerative disorder affecting one or more vertebral discs of the lumbar spine.


inner ear disorder

A non-neoplastic or neoplastic disorder affecting the inner ear. Causes are inner ear infections, head injuries, and neoplasms (e.g., acoustic schwannoma). Symptoms include dizziness, imbalance, nausea, and vision problems.


polyp

A usually exophytic mass attached to the underlying tissue by a broad base or a thin stalk. Polyps can be neoplastic or non-neoplastic. Neoplastic polyps usually represent proliferations of the epithelium, and are commonly seen in the gastrointestinal tract. Polyps of the gastrointestinal tract are often called adenomas, are associated with dysplasia, and may eventually transform into carcinomas. Non-neoplastic polyps may be inflammatory, degenerative, or the result of malformations.


mitral valve disorder

A disease involving the mitral valve.


ovarian neoplasm

A benign, borderline, or malignant neoplasm involving the ovary.


benign neoplasm of pituitary gland

A benign neoplasm that involves the pituitary gland.


Disorder of vocal cord

A disorder affecting the vocal cords. Representative examples include vocal cord nodules, polyps, leukoplakia, dysplasia, and paralysis.


aortic valve disorder

A disease involving the aortic valve.


Abnormal Echocardiogram

A history of having had an abnormal echocardiogram.


inborn error of immunity

A disorder in which the immune system is unable to mount an adequate immune response.


Fractured lower leg

Bone fracture anywhere in the tibia, fibula, or ankle.


Abnormality on pulmonary function testing

Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography.


Deformity

An anatomic abnormality that is either present at birth or appears later in life.


Acanthamoeba infectious disease

A infectious disease involving the Acanthamoeba.


adjustment disorder

A category of psychiatric disorders which are characterized by emotional or behavioral symptoms that develop within 3 months of a stressor and do not persist for more than an additional 6 months after the stressor is no longer present.


Adverse drug response

An unpleasant or harmful reaction resulting from treatment with a drug.


Bone lesion

A localized pathological or traumatic structural change, damage, deformity, or discontinuity of bone.


Antidepressant drug level above therapeutic


autonomic neuropathy

An inherited or acquired peripheral neuropathy affecting the autonomic nervous system. It results in disruption of the involuntary body functions. Inherited causes include Fabry disease and porphyrias. Acquired causes include diabetes, uremia, hepatic disorders, vitamin deficiencies, toxins, and drug toxicities.


bone marrow disorder

Any disease of the bone marrow.


Cardioactive drug level above therapeutic


carotid artery disorder

A disease involving the carotid artery segment.


chondromalacia

Pathological processes involving the chondral tissue (cartilage).


uterine cervix carcinoma in situ

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) - 2003


Amrubicin

Amrubicin is a third-generation anthracycline and potent topoisomerase II inhibitor, for used in the treatment of small-cell lung cancer (SCLC) in Japan.

A synthetic anthracycline antibiotic with molecular formula C25H25NO9. A specific inhibitor of topoisomerase II, it is used (particularly as the hydrochloride salt) in the treatment of cancer, especially lung cancer, where it is a prodrug for the active metabolite, ambrucinol.


epidural abscess

Circumscribed collections of suppurative material occurring in the spinal or intracranial epidural space. The majority of epidural abscesses occur in the spinal canal and are associated with osteomyelitis of a vertebral body; analgesia, epidural; and other conditions. Clinical manifestations include local and radicular pain, weakness, sensory loss, urinary incontinence, and fecal incontinence. Cranial epidural abscesses are usually associated with osteomyelitis of a cranial bone, sinusitis, or otitis media. (From Adams et al., Principles of Neurology, 6th ed, p710 and pp1240-1; J Neurol Neurosurg Psychiatry 1998 Aug;65(2):209-12)


Extranodal marginal zone B-cell lymphoma (MALT type)


Fat Necrosis

Destruction of adipose tissue caused by the activity of lipase on damaged fat cells.


Recurrent tumor

The reemergence of a neoplasm after a period of remission.


Abnormality of the nose

An abnormality of the nose.


Obstruction

Blockage of the normal flow of the contents of an anatomical passageway.


obstructive lung disease

Any disorder marked by obstruction of conducting airways of the lung. airway obstruction may be acute, chronic, intermittent, or persistent.


pancreatic neoplasm

A benign or malignant neoplasm involving the pancreas.


Parainfluenza Virus Infections

A viral infection caused by a parainfluenza virus, typically resulting in infections of the lower respiratory tract.


Parasomnia

An undesirable physical event or experience that occurs during entry into sleep, during sleep, or during arousal from sleep.


Pulmonary Function Test Decreased

A decrease in any of the parameters used to measure the mechanical function of the lungs and upper airway.


Pulmonary toxicity

Toxicity that impairs or damages the lung(s). This condition is often caused by the administration of a pharmaceutical agent that causes damage to the lungs.


Food intolerance

A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction.


Malignant neoplasm of stomach stage IV

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 7th ed.)


glomerulosclerosis

A hardening of the kidney glomerulus caused by scarring of the blood vessels.


Liver Lesion

A localized pathological or traumatic structural change, damage, deformity, or discontinuity of the liver.


hepatobiliary disorder

A non-neoplastic or neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples of non-neoplastic disorders include hepatitis, cirrhosis, cholangitis, and cholecystitis. Representative examples of neoplastic disorders include hepatocellular adenoma, hepatocellular carcinoma, and cholangiocarcinoma.


lung neoplasm

A benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma.


Abnormal lymphocyte morphology

An abnormality of lymphocytes.


skin pigmentation disorder

A pigmentation disease that involves the zone of skin.


Renal Mass

An abnormal growth in the kidney.


viral respiratory tract infection

A respiratory tract infection caused by a virus. Viruses represent the most common causes of upper and lower respiratory tract infections and include rhinoviruses, influenza viruses, parainfluenza viruses, and respiratory syncytial virus.


Vascular Access Complication

Complications related to damage at the vascular access site. Examples include bleeding, formation of hematoma, aneurysm, pseudoaneurysm, or arteriovenous fistula, development of infection, and catheter thrombosis.


capillary disorder

A disease involving a capillary.


nasal disorder

A disease involving the nose.


paranasal sinus disorder

A disease involving the paranasal sinus.


Abnormal Urine Test Result

A laboratory test result indicating a finding outside the parameters of normal urine measurements.


Soft Tissue Infection

A bacterial infectious process affecting the soft tissues. A severe form caused by anaerobic or aerobic bacteria is associated with soft tissues necrosis and affects the subcutaneous adipose tissue, muscles, fascia, and the skin.


Small intestinal stenosis

The narrowing or partial blockage of a portion of the small intestine.


Lipohypertrophy

Hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin.


Leukemia recurrent

The reemergence of leukemia after a period of remission.


Non-Cardiac Chest Pain

Pain in the chest unrelated to a heart disorder.


Tooth Fractures

Broken tooth affecting any portion of tooth: root fracture, crown-root, broken tooth (crown fracture), chipped tooth. A crown fracture can involve the pulp. Tooth fracture sequelae range in severity from cosmetic defects to tooth death. Involvement of the pulp is a more important indicator of severity of tooth fracture than is the amount of the tooth affected.


Scleroderma renal crisis

The onset of acute renal failure, normally coupled with marked hypertension in a patient with scleroderma.


Enterovesical Fistula

An abnormal communication between the urinary bladder and the intestine.


hypophysitis

Inflammation of the pituitary gland.


hyperamylasemia

Abnormally high level of amylase in the blood.


melanoma, cutaneous malignant, susceptibility to, 2

Clinically atypical nevi (usually exceeding 5 mm in diameter and having variable pigmentation and ill defined borders) with an increased risk for development of non-familial cutaneous malignant melanoma. Biopsies show melanocytic dysplasia. Nevi are clinically and histologically identical to the precursor lesions for melanoma in the B-K mole syndrome. (Stedman, 25th ed)


facial spasm

Sudden, repetitive, nonrhythmic motor movements (spasms), involving the eyes and muscles of the face.


effusion

A collection of fluid in a body cavity, which may be the result of a non-neoplastic disorder (e.g. heart failure) or a tumor (e.g. carcinoma of the lung).


Non-Infectious Cystitis

An inflammation of the bladder which is not caused by an infection of the urinary tract. Representative examples include interstitial cystitis and radiation-induced cystitis.


postural orthostatic tachycardia syndrome

A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart.


Hypophagia

Reduced ingestion of food.


Macular scar

Scar tissue in the macula.


Fungal endophthalmitis

Inflammation of the lining of the ocular cavities, which results from a fungal infection.


Crouzon syndrome-acanthosis nigricans syndrome

Crouzon syndrome with acanthosis nigricans (CAN) is a very rare, clinically heterogeneous form of faciocraniostenosis with Crouzon-like features and premature synostosis of cranial sutures (Crouzon disease), associated with acanthosis nigricans (AN).


Metamorphopsia

A visual anomaly in which images appear distorted. A grid of straight lines appears wavy and parts of the grid may appear blank.


International normalized ratio fluctuation


Polypoidal choroidal vasculopathy

The presence of aneurysmal polypoidal lesions in the choroidal vasculature. The aneurysmal dilatations, also known as polyps, may be found at subfoveal, juxtafoveal, extrafoveal, peripapillary or even peripheral regions. These polypoidal dilatations may be visible as reddish-orange subretinal nodules during ophthalmoscopic examination. The polypoidal lesions are best detected on indocyanine green angiography (ICGA) and might be associated with a branching vascular network (BVN) of neovascularization.


Gene mutation identification test positive


spondylolisthesis

A condition in which there is forward displacement of a vertebral bone over the on below it.


Hyperglycemic hyperosmolar nonketotic syndrome


metastatic squamous cell carcinoma

A squamous cell carcinoma which has spread from its original site of growth to another anatomic site.


Perforation of bladder

A rupture in the bladder wall due to traumatic or pathologic processes.


Atlantoaxial instability

Abnormally increased movement at the junction between the first cervical (atlas) and the second cervical (axis) vertebrae as a result of either a bony or ligamentous anomaly.


Upper motor neuron dysfunction

A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs.


Cerebral artery stenosis

Narrowing or constriction of the inner surface (lumen) of a cerebral artery.


Rh Incompatibility

A complication during pregnancy; it occurs when the mother is Rh-negative and the infant is Rh-positive. This complication generally does not affect first-born Rh-positive babies. Rh-positive newborn babies from subsequent pregnancies develop complications of Rh incompatibility which include hemolysis, jaundice, enlarged liver and spleen, petechiae, hypotonia, neurologic damage, and heart problems.


ichthyosis prematurity syndrome

Ichthyosis prematurity syndrome is a rare, syndromic congenital ichthyosis characterized by premature birth (at gestational weeks 30-32, in general) in addition to thick, caseous and desquamating epidermis, neonatal respiratory asphyxia, and persistent eosinophilia. After the perinatal period, a spontaneous improvement in the health of affected patients is observed and skin features (vernix caseosa-like scale) evolve into a mild presentation of flat follicular hyperkeratosis with atopy.


familial atrioventricular septal defect

A spectrum of septal defects involving the atrial septum; ventricular septum; and the atrioventricular valves (tricuspid valve; bicuspid valve). These defects are due to incomplete growth and fusion of the endocardial cushions which are important in the formation of two atrioventricular canals, site of future atrioventricular valves.


autism

Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior.


Lower respiratory tract infection bacterial


Sudden unexpected death in epilepsy

Sudden unexpected death in epilepsy (SUDEP) is a sudden, unexpected, witnessed or unwitnessed, non-traumatic and non-drowning death, occurring in benign circumstances, in an individual with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus, in which postmortem examination has not revealed a cause of death.


Sleep disorder due to a general medical condition


Enteroviral encephalitis

Inflamation of the brain related to infection by an enterovirus.


Non-high-density lipoprotein cholesterol increased


Lichenoid actinic keratosis

A benign intraepidermal squamoproliferative neoplasm characterized by irregular acanthosis, hyperkeratosis, parakeratosis, and prominent chronic inflammation.


heart septal defect

A congenital disorder characterized by the presence of an abnormal communication between the atria or the ventricles of the heart due to defects in the cardiac septum.


volvulus of midgut

A congenital abnormality in which the intestine is abnormally rotated (twisted). It may result in intestinal obstruction.


multiple system atrophy

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure (cardiovascular and/or urinary), parkinsonism, cerebellar impairment and corticospinal signs with a median survival of 6-9 years.


neurodevelopmental disorder

A behavioral and cognitive disorder with onset during the developmental period that involves impaired or aberrant development of intellectual, motor, or social functions.


Multiple lentigines

Presence of an unusually high number of lentigines (singular: lentigo), which are flat, tan to brown oval spots.


Gastrointestinal inflammation

Inflammation of the alimentary part of the gastrointestinal system.


Labeled drug-drug interaction medication error


Labeled drug-disease interaction medication error


extrapulmonary tuberculosis

A tuberculosis that occurs at body sites other than the lung.


Stoma Site Infection

An infectious process affecting a surgically created opening in the surface of the body.


Positive EBV Test

A laboratory test result indicating the presence of the Epstein-Barr virus in a biological sample.


Breakthrough pain

A episode of severe pain that breaks through (i.e., temporarily exacerbates) a period of persistent pain.


Erosion of oral mucosa

Loss of the superficial layer of the oral mucosa usually resulting in a shallow or crusted lesion.


Placental infarction

Interruption of the blood supply to a portion of the placenta, resulting in ischemic necrosis.


Clodronic Acid

A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.


Feculent vomiting

Vomiting of material that is of fecal origin.


Dactylitis

Inflammation of the fingers or toes. This may be accompanied by pain and discoloration.


Device related infection

An infectious disorder caused by the use of a medical device.


Infusion Site Extravasation

Leakage of a pharmacologic or a biological substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation, and pain at the infusion site.


Abnormal breath sound

An anomalous (adventitious) sound produced by the breathing process.


Tachyphrenia

The sensation that thoughts are moving too quickly.


Head titubation

A head tremor of moderate speed (3 to 4 Hz) in the anterior-posterior direction.


plasmablastic lymphoma

An aggressive diffuse large B-cell lymphoma frequently arising in the setting of HIV infection and characterized by the presence of large neoplastic cells resembling B-immunoblasts which have the immunophenotypic profile of plasma cells. Sites of involvement include the oral cavity, sinonasal cavity, skin, soft tissues, gastrointestinal tract, and bone.


immune reconstitution inflammatory syndrome

An inflammatory condition that arises after initiating antiretroviral therapy (ART) therapy in HIV-infected patients that results from restored immunity to specific infectious or non-infectious antigens.


latent tuberculosis infection

Mycobacterium tuberculosis infection that does not induce infectious expression of the disease in the affected person, although it can cause continuous immune response generated towards TB antigens; person having LTBI are asymptomatic and acting as a reservoir of active tuberculosis tuberculosis cases and Mycobacterium tuberculosis and run a 5-10% risk of reactivating tuberculosis throughout their lives.


Lower respiratory tract infection fungal


Mycotic pericarditis

Pericarditis that is caused by an infection with a fungal agent.


Dental Fistula

Localized collection of pus in the tissues that enclose the root of a tooth and is associated with the presence of a sinus tract.


Spontaneous hematomas

Spontaneous development of hematomas (hematoma) or bruises without significant trauma.


Urinary Tract Fistula

An abnormal communication between any part of the urinary system and another organ or cavity.


Bone marrow hypocellularity

A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat.


Oral Cavity Fistula

An abnormal communication between the oral cavity and the adjacent tissues.


Bronchial hemorrhage

Bronchial hemorrhage is a focal bleeding located in the bronchial system. It can be diagnosed by tracheobronchoscopy.


Ovarian Hemorrhage

Bleeding originating from the ovary.


Mucosal Infection

An acute or chronic infectious process affecting a mucosal surface.


Musculoskeletal Deformity

Congenital or acquired deformity of the musculoskeletal system.


Vaginal fistula

The presence of a fistula of the vagina.


Esophageal Fistula

An abnormal communication between the esophagus and another organ or anatomic site.


Digestive System Anastomotic Leakage

Leakage due to breakdown of a gastrointestinal anastomosis.


Cardiovascular insufficiency

Circulatory insufficiency due to a decrease in the force of the cardiac contractions and/or the tone of the vascular walls.


Left ventricle outflow tract obstruction


Truncal obesity

Obesity located preferentially in the trunk of the body as opposed to the extremities.


Fine motor delay

Delayed acquisition of age appropriate motor milestones that produce small and precise movements.


Stress urinary incontinence

Involuntary urine leakage synchronous with exertion, or actions such as sneezing, or coughing.


central nervous system leukemia

Leukemia infiltrating the central nervous system structures.


acute graft versus host disease

A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, usually affecting the skin, liver, and GI tract. The onset is usually within one hundred days of transplantation or immunologic manipulation.


Cytopenia

A laboratory test result indicating an abnormally low quantity of circulating blood cells.


Acute graft versus host disease in liver


Acute graft versus host disease in intestine


Tako-tsubo cardiomyopathy

Takotsubo cardiomyopathy (TC) is a recently described acute cardiac syndrome that mimics acute myocardial infarction and is characterized by ischemic chest symptoms, an elevated ST segment on electrocardiogram, and elevated levels of cardiac disease markers.


keratosis pilaris

A form of dry skin characterised by hair follicles plugged by scale.


Hypersexuality

Pathological persistent sexual disinhibiting behavior, directed at oneself or to others.


Toxic anterior segment syndrome

An acute postoperative inflammatory reaction in which a noninfectious substance enters the anterior segment of the eye and induces toxic damage to the intraocular tissues.


Tendon pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to a tendon.


latent autoimmune diabetes in adults

A type 1 diabetes mellitus that is characterized by a less intensive autoimmune process, highly variable β-cell destruction, different degrees of insulin resistance and heterogeneous titre and pattern of islet autoantibody, sharing features with both type 1 and type 2 diabetes mellitus.


human herpesvirus 8 infection

An infectious process caused by the human herpesvirus 8. This infection is associated with Kaposi sarcoma.


hematopoietic and lymphoid system neoplasm

Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). --2003


Recurrent Medulloblastoma

The reemergence of medulloblastoma after a period of remission.


Recurrent ovarian cancer

The reemergence of ovarian carcinoma after a period of remission.


acute interstitial pneumonia

Acute interstitial pneumonia (AIP), also referred to as Hamman-Rich syndrome, is a rapidly progressive and histologically distinct form of idiopathic interstitial pneumonia.


Human herpesvirus 6 infection reactivation


alveolar periostitis

A condition sometimes occurring after tooth extraction, particularly after traumatic extraction, resulting in a dry appearance of the exposed bone in the socket, due to disintegration or loss of the blood clot. It is basically a focal osteomyelitis without suppuration and is accompanied by severe pain (alveolalgia) and foul odor. (Dorland, 28th ed)


Injury of liver

Damage to liver structure or function due to trauma or toxicity.


Fistula Discharge

The leakage of a substance from a fistula.


Regurgitation

Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward flowing of blood into the heart, or between the chambers of the heart when a valve is incompetent.


Right atrial enlargement

Increase in size of the right atrium.


Sleep-related eating disorder

Eating during sleep.


osteoradionecrosis

Necrosis of bone following radiation injury.


disorder of pharynx

A non-neoplastic or neoplastic disorder that affects the pharynx. Representative examples include pharyngitis and carcinoma.


Radiation necrosis

Tissue necrosis due to radiation exposure.


cloacal exstrophy

A major birth defect representing the severe end of the spectrum of the exstrophy-epispadias complex (EEC) characterized by omphalocele, exstrophy, imperforate anus and spinal defects (also referred to as the OEIS complex), often associated with other malformations.


nephrogenic systemic fibrosis

Nephrogenic systemic fibrosis (NSF) is a rare systemic fibrosing condition observed in renally impaired patients and characterized by a hardening and thickening of the skin with fibrotic plaques or papules, pruritus, joint pain and stiffness, muscle weakness, limitation of range of motion, and yellowed eyes. It is generally associated with administration of gadolinium-based magnetic resonance imaging contrast agents (GBCA) in patients with kidney disease.


Rotavirus infection

Infection with any of the rotaviruses. Specific infections include human infantile diarrhea, neonatal calf diarrhea, and epidemic diarrhea of infant mice.


Organizing pneumonia

Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias, but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal and sometimes bronchocentric. Other manifestations of organizing pneumonia include groundglass opacity, tree-in-bud pattern, and nodular opacities.


chromosomal disorder

Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)


Adverse reactions

Any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out.


Impaired vibratory sensation

A decrease in the ability to perceive vibration. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to bony prominences such as the malleoli at the ankles or the metacarpal-phalangeal joints. There is a slow decay of vibration from the tuning fork. The degree of vibratory sense loss can be crudely estimated by counting the number of seconds that the examiner can perceive the vibration longer than the patient.


mouth disorder

A disease involving the mouth.


Heart valve regurgitation

Dysfunction of one of the cardiac valves characterized by incomplete valve closure.


Toxic polyneuropathy

Polyneuropathy that is caused by exposure to toxins.


Skin plaque

A plaque is a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter.


Hyperlipasaemia

A laboratory test result which indicates increased levels of lipase in a biologic specimen.


focal segmental glomerulosclerosis

A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.


Upper airway obstruction

Increased resistance to the passage of air in the upper airway.


Oromandibular dystonia

A kind of focal dystonia characterized by forceful contractions of the face, jaw, and/or tongue causing difficulty in opening and closing the mouth and often affecting chewing and speech.


myelodysplastic syndrome with multilineage dysplasia

Refractory cytopenias with multilineage dysplasia (RCMD) is a frequent subtype of myelodysplastic syndrome (MDS) characterized by 1 or more cytopenias in the peripheral blood and dysplasia in 2 or more myeloid lineages.


Eastern Cooperative Oncology Group performance status worsened


Malar rash

An erythematous (red), flat facial rash that affects the skin in the malar area (over the cheekbones) and extends over the bridge of the nose.


intellectual disability

A broad category of disorders characterized by an impairment to the intelligence an individual possesses. These impairments can result from trauma, birth, or disease and are not restricted to any particular age group.


cerebral amyloid angiopathy

Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.


burning mouth syndrome

A condition characterized by a burning or tingling sensation on the lips, tongue, or entire mouth.


cardio-renal syndrome

A disorder of the heart and kidneys in which dysfunction of one of the organs induces dysfunction of the other organ.


Transaminitis

Abnormally high levels of alanine transaminase (ALT) and/or aspartate transaminase (AST) in the blood.


Epstein-Barr virus-associated malignant lymphoproliferative disorder

A lymphoproliferative disorder associated with Epstein-Barr virus. This category includes, but is not limited to, Burkitt lymphoma, classic Hodgkin lymphoma, and lymphomas arising in immunocompromised individuals.


Creatinine clearance-glomerular filtration outside reference range


Decreased fetal movement

An abnormal reduction in quantity or strength of fetal movements.


myelodysplastic syndrome associated with isolated del(5q)

A myelodysplastic syndrome characterized by a deletion between bands q31 and 33 on chromosome 5. The number of blasts in the bone marrow and blood is <5%. The bone marrow is usually hypercellular or normocellular with increased number of often hypolobated megakaryocytes. The peripheral blood shows macrocytic anemia. This syndrome occurs predominantly but not exclusively in middle age to older women. The prognosis is good and transformation to acute leukemia is rare. (WHO, 2001)


C-reactive protein outside reference range


Respiratory syncytial virus test positive


Pulmonary hypertensive crisis

Pulmonary hypertensive crisis involves sudden and potentially lethal increases in PAP and PVR that cause acute rise in right atrial and right ventricular end-diastolic pressure accompanied by low cardiac output.


Facial asymmetry

An abnormal difference between the left and right sides of the face.


Pulmonary cyst

A round circumscribed space within a lung that is surrounded by an epithelial or fibrous wall of variable thickness. A cyst usually has a thin and regular wall (less than 2 mm) and contains air, although some may contain fluid.


Overlap syndrome

An autoimmune, connective tissue disorder in which the patient exhibits features from two or more diseases. These typically include systemic sclerosis, dermatomyositis, polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and Sjogren syndrome; in pediatrics the respective pediatric entities are encountered.


Anti-cyclic citrullinated peptide antibody positive


Terminal insomnia

A type of insomnia characterized by waking up (too) early in the morning.


autoimmune pancreatitis

Autoimmune pancreatitis (AIP) is a rare pancreatic disease characterized by chronic non-alcoholic pancreatitis that presents with abdominal pain, steatorrhea, obstructive jaundice and responds well to steroid therapy and is seen in two subforms: type 1 AIP which affects elderly males, involves other organs and has increased immunoglobin G4 (IgG4) levels and type 2 AIP which affects both sexes equally but presents at a younger age and has no other organ involvement or increased IgG4 levels.


tubulointerstitial nephritis and uveitis syndrome

An autoimmune disorder comprising tubulointerstitial nephritis and uveitis.


Delayed gross motor development

A type of motor delay characterized by a delay in acquiring the ability to control the large muscles of the body for walking, running, sitting, and crawling.


acute kidney failure

Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria.


Iotalamic acid

A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.


Bambuterol

selective inhibitor of butyrylcholinesterase & acetylcholinesterase

A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.


swine influenza

An acute viral respiratory infection caused by a strain of influenza virus which is endemic in swine (pigs). Rarely reported in humans prior to 2009, the disease is caused by a mutated strain of swine influenza A (H1N1) virus. It is highly contagious and spreads mainly through coughing and sneezing. Signs and symptoms include fever, chills, coughing, sore throat headache, muscle ache, and generalized weakness. Antiviral medications are most effective in the first two days of the illness.


Subretinal fluid

Edema/fluid accumulating between the retinal pigment epithelium and Bruch's membrane.


Lung Injury

Damage to the lung from traumatic or pathologic processes.


idiopathic camptocormia

Idiopathic camptocormia is a postural disease characterized by an anterior flexion of the torso (during walking or standing) that resolves in the supine position and that is caused by weakness of the lumbar paraspinal muscles (spinal extensors), due to massive fatty infiltrations of posterior spinal muscles, without an identifiable etiology.


Reticulin Fibrosis of the Bone Marrow

Increased reticular fiber deposition within bone marrow.


Spinal Injuries

Damage to the spine that results in impaired function.


Renal hemangioma

A rare hemangioma arising from the kidney.


Foreign Bodies

Extraneous material within the body.


Executive dysfunction

Cognitive, emotional, and behavioral difficulties that often occur in conjunction with frontal lobe disorders, including traumatic injury and dementia. It is also a feature of attention deficit disorder and other non-trauma-induced conditions.


Infective exacerbation of bronchiectasis


Motor delay

A type of Developmental delay characterized by a delay in acquiring motor skills.


refractory malignant neoplasm

A malignant neoplasm that does not respond to treatment.


Mycobacterium tuberculosis complex test positive


Chemical peritonitis

A non-infectious inflammation of the peritoneum.


Increased urine urobilinogen

An elevated concentration of urobilinogen in the urine.


Hypoxic-Ischemic Encephalopathy

Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures.


hypertension, pregnancy-induced

A hypertensive disorder that develops during pregnancy.


Distributive shock

A hyperdynamic process resulting from excessive vasodilatation. Impaired blood flow causes inadequate tissue perfusion, which can lead to end-organ damage


Infective pulmonary exacerbation of cystic fibrosis


Heparin-induced thrombocytopenia test positive


Intentional medical device removal by patient


Hypocitraturia

A lower than normal concentration of citrate(3-) in the urine.


Stage I Ovarian Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0. T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Ovarian epithelial cancer stage II

Stage II includes: T2, N0, M0.  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Ovarian cancer stage III

Stage III includes: T3, N0, M0.  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


colon dysplasia

A morphologic finding indicating the presence of dysplastic glandular epithelial cells in the colonic mucosa. There is no evidence of invasion.


Aminopterin/Methotrexate embryofetopathy is a syndrome of developmental anomalies characterized by growth deficiency, facial dysmorphism and skull, limb and neural defects secondary to maternal exposure to aminopterin or methotrexate (MTX) during pregnancy.


Lower Urinary Tract Symptoms

Symptoms that result from pathologic processes affecting the urinary bladder and/or urethra. They include urinary frequency and urgency, dysuria, nocturia, incomplete voiding, and poor stream during urination.


Acute repetitive seizure

A fourfold or greater increase of usual seizure frequency within a 3-day period, where the patient demonstrates full recovery between seizure events within the cluster. The seizure cluster should be recognisable by the primary clinician, carer or patient.


Expanded disability status scale score increased


Resting tremor

A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse.


Dydrogesterone

A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit OVULATION.


hemophagocytic syndrome

Hemophagocytic syndrome (HPS) is a rare immune disease and a potentially life-threatening disorder characterized by cytokine storm and overwhelming inflammation causing fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia, and hemophagocytosis in bone marrow, liver, spleen or lymph nodes. It can be either primary due to a genetic defect (primary hemophagocytic lymphohistiocytosis), or secondary to malignancies, to infections, most commonly with viruses such as Epstein-Barr virus or cytomegalovirus, human immunodeficiency virus, or to autoimmune disorders such as systemic lupus erythematosus or adult-onset Still disease (secondary hemophagocytic lymphohistiocytosis).


N-terminal prohormone brain natriuretic peptide abnormal


N-terminal prohormone brain natriuretic peptide increased


Environmental Exposure

Exposure to potentially harmful chemical, physical, or biological agents via the environment.


stiff-person syndrome

Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.


Chronic graft versus host disease in intestine


Chronic graft versus host disease in skin


Chronic graft versus host disease in liver


Cutaneous wound

A cutaneous wound is a defined as a disruption of normal anatomic structure and function of the skin that occured owing to an injury of the skin. Wound healing is a dynamic, interactive processinvolving soluble mediators, blood cells, extracellularmatrix, and parenchymal cells. Wound healing has three phases: inflammation, tissue formation, and tissue remodeling, that overlap in time.


Drug-Induced Liver Disease

Damage to the liver tissue due to drug overdose.


Choletec

A radioconjugate composed of the iminodiacetic acid derivative mebrofenin bound to an isotope of the synthetic element technetium (Tc). Upon administration and rapid clearance from the circulation, technetium Tc 99m mebrofenin is secreted into the hepatobiliary system, emitting gamma rays that are detectable with planar scintigraphy or single photon emission computer tomography (SPECT). Mebrofenin has no pharmacological effect at the recommended dosage for diagnostic imagining.


Virus-associated trichodysplasia spinulosa is a rare infectious skin disease characterized by the development of follicular papules with keratin spicules in various parts of the body, predominantly in the face (e.g. nose, eyebrows, auricles), that is due to polyomavirus infection in immunocompromized patients.


steroid-responsive encephalopathy associated with autoimmune thyroiditis


Substance induced psychotic disorder

A psychotic disorder characterized by prominent hallucinations or delusions that have been determined to be etiologically linked to substance use, intoxication or withdrawal.


Inadequate aseptic technique in use of product


Pancreatic steatosis

Fat infiltration in the pancreas.


Immune reconstitution inflammatory syndrome associated tuberculosis


Central Nervous System Fungal Infections


Post-injection delirium sedation syndrome


brachydactyly

A disease characterized by the presence of brachydactyly, including syndromic and non-syndromic forms.


preterm premature rupture of the membranes

A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation.


burkholderia infectious disease

Infections with bacteria of the genus Burkholderia.


Primary malignant neoplasm of unknown site


Recurrent Liver Carcinoma

The reemergence of liver carcinoma after a period of remission.


breast intraductal proliferative lesion

A group of non-invasive epithelial proliferations that occur in the ductal system of the breast. The vast majority of cases arise in the terminal ductal lobular units. This category includes atypical ductal hyperplasia, usual ductal hyperplasia, flat epithelial atypia, and ductal carcinoma in situ. There is an increased risk for subsequent development of invasive breast carcinoma.


invasive lobular breast carcinoma

An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma. The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures.


Plasma cell myeloma recurrent

The reemergence of plasma cell myeloma after a period of remission.


congenital isolated adrenocorticotropic hormone deficiency

A hypopituitarrium that is characterized by a decreased or absent production of adrenocorticotropic hormone by the pituitary gland.


Postural tremor

A type of tremors that is triggered by holding a limb in a fixed position.


reversible cerebral vasoconstriction syndrome

Reversible cerebral vasoconstriction syndrome (RCVS) is an infrequent cerebrovascular disorder characterized by severe headaches with or without focal neurological deficits or seizures, and a reversible segmental and multifocal vasoconstriction of cerebral arteries.


clear cell renal carcinoma

A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network. The tumor may metastasize to unusual sites and late metastasis is common.


ovarian teratoma

A non-seminomatous germ cell tumor arising from the ovary. It is characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). According to the level of differentiation of the tissues which comprise the tumor, ovarian teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal type-tissues. Mature ovarian teratomas without a fetal-type component have an excellent outcome. The prognosis of immature ovarian teratomas is related to the grade and stage of the tumor.


Decorticate Posture

A posture characterized by body rigidity, flexion of the arms over the chest, clenched fists,  and extension of the legs. It may indicate cerebral damage.


appendix cancer

A malignant neoplasm involving the vermiform appendix


anaplastic large cell lymphoma

Anaplastic large cell lymphoma (ALCL) is a rare and aggressive peripheral T-cell non-Hodgkin lymphoma, belonging to the group of CD30-positive lymphoproliferative disorders, which affects lymph nodes and extranodal sites. It is comprised of two sub-types, based on the expression of a protein called anaplastic lymphoma kinase (ALK): ALK positive and ALK negative ALCL.


drug hypersensitivity syndrome

A potentially life-threatening hypersensitivity reaction to a pharmacologic substance that is characterized by rash, lymphadenopathy, fever, hematologic abnormalities and involvement of one or more internal organs.


Pregnancy exposure

Exposure of pregnant women to toxins from any source, such as environmental toxins or chemicals, that may potentially cause problems such as miscarriage, preterm delivery, low birth weight, and, in some cases, developmental delays in infants.


Therapeutic drug monitoring analysis not performed


Injury of musculoskeletal system

Damage to the muscles, bones and their supportive structural attachments.


pneumocystosis

Human pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localised to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.


Infection by Pneumocystis jirovecii (disorder)


developmental dysplasia of the hip

A spectrum of hip abnormalities commonly presenting in infancy involving the relationship between the femoral head and the acetabulum and that includes subluxation or dislocation at rest or upon provocation.


Hypothalamic pituitary adrenal axis suppression


Parenteral nutrition associated liver disease


Right ventricular dilatation

Enlargement of the chamber of the right ventricle.


Ectopic pregnancy with contraceptive device


Fetal heart rate deceleration abnormality


Reduced forced vital capacity

An abnormal reduction in the amount of air a person can expel following maximal inspiration.


Portal fibrosis

Fibroblast proliferation and fiber expansion from the portal areas to the lobule.


language disorder

A category of disorders characterized by an impairment in the development of an individual's language capabilities, which is in contrast to his/her non-verbal intellect.


Device embolization

Movement of a medical device to an unintended location within the body with resulting obstruction of an organ or vessel.


Change in Therapeutic Response

Change in response to treatment or cure of a disorder or disease.


Toxic Erythema of Chemotherapy

Painful red or purple patches, edematous plaques or blisters on the hands, feet, extremities or intertriginous regions; the onset can occur days to months after receiving chemotherapy.


Graft versus host disease in gastrointestinal tract


Internal hemorrhage

The presence of hemorrhage within the body.


mast cell activation syndrome

A clinically defined disease states with a largely unknown morphological background. Acute mast cell activation (MCA) is commonly seen in allergic reactions and often leads to the clinical signs and symptoms of anaphylaxis. Severe or even life‐threatening MCA may occur when the burden of mast cells is high and/or these cells are in an hyperactivated state. Mastocytosis may be associated with mast cell activation syndrome (MCAS).


intestinal tuberculosis

A tuberculosis that involves the intestine.


Demodex folliculitis

A demodicidosis that involves the hair follicle.


Disability assessment scale score increased


Drug monitoring procedure incorrectly performed


orbital plasma cell granuloma

A nonspecific tumor-like inflammatory lesion in the orbit of the eye. It is usually composed of mature lymphocytes; plasma cells; macrophages; leukocytes with varying degrees of fibrosis. Orbital pseudotumors are often associated with inflammation of the extraocular muscles (orbital myositis) or inflammation of the lacrimal glands (dacryoadenitis).


Unmasking of previously unidentified disease


Poor fine motor coordination

An abnormality of the ability (skills) to perform a precise movement of small muscles with the intent to perform a specific act. Fine motor skills are required to mediate movements of the wrists, hands, fingers, feet, and toes.


Documented hypersensitivity to administered product


Stenosis

Narrowing or stricture of a vessel, duct or canal.


Enbucrilate

A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.

A macromolecule composed of repeating butyl 2-cyanopropanoate units.


Wrong technique in product usage process


Unintentional use for unapproved indication


Prescription drug used without a prescription


Delayed Graft Function

The need for dialysis within a week of kidney transplant.


BCGosis

Distant, or disseminated infection with Bacillus Calmette-Guerin (BCG) following vaccination associated with failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis.


Perforation

A hole or opening made through a membrane or other tissue or material.


Osteonecrosis of external auditory canal


Hyperinsulinemic hypoglycemia

An increased concentration of insulin combined with a decreased concentration of glucose in the blood.


Intrusive thoughts

An unwelcome and persistent idea, image or thought that is upsetting to an individual.


infantile apnea

Infantile apnea is a cessation of respiratory air flow that may affect newborns or older children because of neurological impairment of the respiratory rhythm or obstruction of air flow through the air passages. The symptoms include cyanosis, pallor or bradycardia and snoring in case of obstructive apnea.


Vitreous haze

Vitreous haze is the obscuration of fundus details by vitreous cells and protein exudation.


Cornea verticillata

Golden brown or gray deposits with a clockwise, whorl-like distribution in the inferior interpalpebal portion of the cornea.


Immune-mediated adverse reaction

An adverse event resulting from an immune system reaction to a drug or device. It can affect any organ or system.


ureterolithiasis

The presence of a calculus in the ureter of the kidney; this is most often composed of mineral salts and proteins.


neurosarcoidosis

A sarcoidosis that involves the nervous system.


paraneoplastic limbic encephalitis

A rare disorder characterized by degenerative changes in the limbic area of the brain. Causes include infections and autoimmune conditions; it may also manifest as a paraneoplastic syndrome, most often caused by small cell lung carcinoma. Signs and symptoms include behavioral changes, hallucinations and dementia.


pathological gambling

A disorder characterized by a preoccupation with gambling and the excitement that gambling with increasing risk provides. Pathological gamblers are unable to cut back on their gambling, despite the fact that it may lead them to lie, steal, or lose a significant relationship, job, or educational opportunity.


Neurasthenia

An episode of acute, severe anxiety or depression associated with an inability to function as normal.


Behavioral and psychological symptoms of dementia


Transformation to acute myeloid leukemia


cholesterol embolism

Blocking of a blood vessel by cholesterol-rich atheromatous deposits, generally occurring in the flow from a large artery to small arterial branches. It is also called arterial-arterial embolization or atheroembolism which may be spontaneous or iatrogenic. Patients with spontaneous atheroembolism often have painful, cyanotic digits of acute onset.


Drug effective for unapproved indication


EBV positive mucocutaneous ulcer

A rare Epstein-Barr virus-positive B-cell lymphoproliferative disorder which presents as an ulcerative mucocutaneous lesion. It is associated with immune suppression, including age-related and drug-induced immunosuppression.


Loss of personal independence in daily activities


Pancreatitis due to pancreatic duct obstruction


Cutaneous lymphoma

A lymphoma involving the skin.


Neoplasm, Residual

Evidence for remaining tumor following primary treatment that is only apparent using highly sensitive techniques.


Sickness

A state of ill health, bodily malfunction, or discomfort.


malakoplakia

Malakoplakia is a chronic multisystem granulomatous inflammatory disease characterized by the presence of single or multiple soft plaques on various organs of the body.


Gastrointestinal vascular malformation hemorrhagic


Increased reactive oxygen species production

An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage.


B-cell aplasia

A condition characterized by extremely low B-cell counts. It occurs when anti-CD19 CAR T-cells attack and kill CD19-expressing B-lymphocytes.


Product administered at inappropriate site


phaeohyphomycosis

An opportunistic fungal infection caused by any of a variety of normally saprophytic fungi with hyaline hyphal elements. For example, Fusarium spp. infect neutropenic patients to cause pneumonia, fungemia, and disseminated infection with cutaneous lesions.


Incorrect route of product administration


Inappropriate schedule of product administration


Intercepted product administration error


Product administered to patient of inappropriate age


Incorrect product administration duration


central nervous system vasculitis

Vasculitis affecting the blood vessels of the brain and/or spinal cord.


Plasma cell myeloma refractory

Plasma cell myeloma that is resistant to treatment.


Vogt-Koyanagi-Harada disease

A bilateral, chronic, diffuse granulomatous panuveitis typically characterized by serous retinal detachment and frequently associated with neurological (meningitis), auditory, and dermatological alterations.


Neonatal seizure

A seizure occurring within the neonatal period (28 days beyond the full term date).


Philadelphia positive chronic myeloid leukemia


Taste Disorders

Conditions characterized by an alteration in the ability to perceive taste.


Autoimmune inflammation of skeletal muscle


Post 5-alpha-reductase inhibitor syndrome


Undetermined manner of death, suicide suspected


New onset diabetes after transplantation


Cerebral venous sinus thrombosis

An intracranial thrombosis of the venous sinuses. These typically present with headache, seizures or venous stroke secondary to raised cerebral venous pressure. Cerebral venous sinus thromboses usually affect larger areas of brain parenchyma than those affected by cerebral vein thromboses.


Bronchiolitis Obliterans Syndrome

Bronchiolitis obliterans following lung or allogeneic hematopoietic cell transplantation.


cell-associated neurotoxicity

Neurotoxicity associated with immune effector cell therapy. It may be characterized by aphasia, altered level of consciousness, motor weakness, seizures, and cerebral edema.


Subcapsular renal hematoma

A collection of blood between the renal capsule and the renal parenchyma.


Chronic graft versus host disease in eye


Failure of child resistant product closure


Congestive hepatopathy

Chronic passive congestion of the liver secondary to right heart failure. Elevation of central venous pressure leads to restriction of the hepatic circulation. Prolonged hepatic venous pressure may lead to liver fibrosis and cirrhosis.


Biliary tract obstruction

Obstruction affecting the biliary tree.


Disseminated varicella zoster virus infection


post-acute COVID-19 syndrome

A constellation of signs and symptoms that can persist for weeks or months after acute infection with SARS-CoV-2, or appear weeks after infection.  This condition may be characterized by fatigue, shortness of breath, difficulty focusing or concentrating ("brain fog"), sleep disorders, fevers, gastrointestinal symptoms, anxiety, and depression.


KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2 (sprot)

A voltage-gated potassium channel KCNH2 that is encoded in the genome of human.


SCN1A_HUMAN Sodium channel protein type 1 subunit alpha (sprot)

A sodium channel protein type 1 subunit alpha that is encoded in the genome of human.


SCN4A_HUMAN Sodium channel protein type 4 subunit alpha (sprot)

A sodium channel protein type 4 subunit alpha that is encoded in the genome of human.


PE2R1_HUMAN Prostaglandin E2 receptor EP1 subtype (sprot)

A prostaglandin E2 receptor EP1 subtype that is encoded in the genome of human.


CP2D6_HUMAN Cytochrome P450 2D6 (sprot)

A cytochrome P450 2D6 that is encoded in the genome of human.


5HT3A_HUMAN 5-hydroxytryptamine receptor 3A (sprot)

A 5-hydroxytryptamine receptor 3A that is encoded in the genome of human.


KCND3_HUMAN Potassium voltage-gated channel subfamily D member 3 (sprot)

A voltage-gated potassium channel KCND3 that is encoded in the genome of human.


KCNA5_HUMAN Potassium voltage-gated channel subfamily A member 5 (sprot)

A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human.


(S)-Nicardipine

S-enantiomer of nicardipine is a calcium entry blocker (slow channel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle without changing serum calcium concentrations

The S-enantiomer of nicardipine.


CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1D that is encoded in the genome of human.


CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human.


KCNN4_HUMAN Intermediate conductance calcium-activated potassium channel protein 4 (sprot)

An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of human.


CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1F that is encoded in the genome of human.


CAC1C_RAT Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of rat.


CAC1S_RAT Voltage-dependent L-type calcium channel subunit alpha-1S (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1S that is encoded in the genome of rat.


Levdobutamine

Levdobutamine, an investigational drug, is a  beta-adrenoceptor agonist selective for the beta1-subtype. It is the cardiotonic agent.

The (S)-enantiomer of dobutamine.


ADRB1_HUMAN Beta-1 adrenergic receptor (sprot)

A beta-1 adrenergic receptor that is encoded in the genome of human.


DYR_MOUSE Dihydrofolate reductase (sprot)

A dihydrofolate reductase that is encoded in the genome of mouse.


DYR_ECOLI Dihydrofolate reductase (sprot)

A dihydrofolate reductase folA that is encoded in the genome of Escherichia coli K-12.


DYR_LACCA Dihydrofolate reductase (sprot)


B0BL08_ECOLX dihydrofolate reductase (trembl)


FOLC_MOUSE Folylpolyglutamate synthase, mitochondrial (sprot)

A folylpolyglutamate synthase, mitochondrial that is encoded in the genome of mouse.


DYR_HUMAN Dihydrofolate reductase (sprot)

A dihydrofolate reductase that is encoded in the genome of human.


ALDR_HUMAN Aldo-keto reductase family 1 member B1 (sprot)

An aldo-keto reductase family 1 member B1 that is encoded in the genome of human.


HDAC2_HUMAN Histone deacetylase 2 (sprot)

A histone deacetylase 2 that is encoded in the genome of human.


HDAC1_HUMAN Histone deacetylase 1 (sprot)

A histone deacetylase 1 that is encoded in the genome of human.


HDAC8_HUMAN Histone deacetylase 8 (sprot)

A histone deacetylase 8 that is encoded in the genome of human.


DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (sprot)

A DNA (cytosine-5)-methyltransferase 1 that is encoded in the genome of human.


DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (sprot)

A DNA (cytosine-5)-methyltransferase 3A that is encoded in the genome of human.


TYSY_HUMAN Thymidylate synthase (sprot)

A thymidylate synthase that is encoded in the genome of human.


MRP5_HUMAN ATP-binding cassette sub-family C member 5 (sprot)

An ATP-binding cassette sub-family C member 5 that is encoded in the genome of human.