Clinical Stage IV Merkel Cell Carcinoma AJCC v8

Stage IV includes: T0-4, Any N, M1. T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. M1: Distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Clinical Stage IIA Merkel Cell Carcinoma AJCC v8

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Stage IIA includes: T2-3, N0, M0. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Clinical Stage IIB Merkel Cell Carcinoma AJCC v8

Stage IIB includes: T4, N0, M0. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Clinical Stage II Merkel Cell Carcinoma AJCC v8

Stage II includes: IIA: (T2-3, N0, M0); IIB: (T4, N0, M0). T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Clinical Stage III Merkel Cell Carcinoma AJCC v8

Stage III includes: T0-4, N1-3, M0. T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1: Metastasis in regional lymph node(s). N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Clinical Stage I Merkel Cell Carcinoma AJCC v8

Stage I includes: T1, N0, M0. T1: Maximum clinical tumor diameter equal to or less than 2 cm. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Small Intestinal Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small intestine. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Small Intestinal Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small intestine.  It is characterized by the presence of malignant large cells.


Recurrent Rectal Cancer

The reemergence of rectal carcinoma after a period of remission.


Rectal adenocarcinoma recurrent

The reemergence of rectal adenocarcinoma after a period of remission.


Radiating Chest Pain in Abdomen

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The location of the radiating chest pain is in the abdomen.


polyatomic cation

A cation consisting of more than one atom.


phosphocholines

Any compound having phosphocholine as part of its structure.


phosphatidylcholine

A glycerophosphocholine that is glycero-3-phosphocholine bearing two acyl substituents at positions 1 and 2.


The conjugate base of a 1,2-diacyl-sn-glycero-3-phosphocholine compound formed by deprotonation of the phosphate OH group.


An ammonium ion that is the conjugate acid of pyridoxamine arising from selective protonation of the primary amino group; major species at pH 7.3.


(S)-Bethanechol

The (S)-enantiomer of bethanechol.


A 1,2-diacyl-sn-glycero-3-phosphocholine where the acyl group at position 1 is unspecified while the acyl group at position 2 is palmitoyl.


glycerophosphocholine

The glycerol phosphate ester of a phosphocholine. A nutrient with many different roles in human health.


A phosphatidylcholine 36:3 in which the acyl groups specified at positions 1 and 2 are octadecanoyl and (6Z,9Z,12Z)-octadecatrienoyl respectively.


ammonium ion derivative

A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).


phosphatidylcholine 32:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 0 double bonds.


A primary ammonium ion that is the conjugate acid of thiamine(1+) resulting from the protonation of the primary amino group.


(R)-Bethanechol

The (R)-enantiomer of bethanechol.


acylcholine

A choline ester formed from choline and a carboxylic acid.


cholines

A quaternary ammonium ion based on the choline ion and its substituted derivatives thereof.


quaternary ammonium ion

A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.


Lumbar Spine Joint Range of Motion Decreased

Decreased flexibility of a lumbar spine joint.


Stage IIIB Cervical Cancer FIGO 2018

Cervical carcinoma with extension to the pelvic wall and/or hydronephrosis or nonfunctioning kidney (unless known to be due to another cause). (FIGO 2018)


Grade 5 Pharynx Stricture or Stenosis, CTCAE


Grade 4 Pharynx Stricture or Stenosis, CTCAE


Grade 1 Pharynx Stricture or Stenosis, CTCAE


Grade 3 Pharynx Stricture or Stenosis, CTCAE


Grade 2 Pharynx Stricture or Stenosis, CTCAE


Leaflet Disruption Due To Calcification

The disturbance of a cusp of a heart valve secondary to the accumulation of calcium on the valve tissue. This most often results in stenosis of the valve.


Leaflet Disruption

The disturbance of a cusp of a heart valve, often resutling in dysfunction of the valve.


Leaflet Disruption Due To Infection

The disturbance of a cusp of a heart valve secondary to infection affecting the valve tissue, which can result in valvular dysfunction.


Leaflet Disruption Due To Unknown Cause

The disturbance of a cusp of a heart valve without an identifiable cause.


Leaflet Disruption Due To Host Tissue Overgrowth

The disturbance of a cusp of a heart valve secondary to an increase in tissue mass at the valve site, which can lead to valve dysfunction. This often happens as a result of fibrosis of tissue surrounding the suture line of a prosthetic valve.


Leaflet Disruption Due To Suture Abrasion

The disturbance of a cusp of a heart valve secondary to irritation by surgical sutures, which can result in valvular dysfunction.


Vulvar Fibroadenoma

A benign epithelial-stromal neoplasm that arises from the vulva and resembles the breast fibroadenoma.


Fibroadenoma of Anogenital Mammary-Type Glands

A benign epithelial-stromal neoplasm that arises from the perineum and resembles the breast fibroadenoma.


Anal Fibroadenoma

A benign epithelial-stromal neoplasm that arises from the anus and resembles the breast fibroadenoma.


Esophageal Squamous Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities involve either the lower or both the lower and the upper half of the esophageal squamous epithelium.


High Grade Esophageal Squamous Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal squamous epithelium.


Low Grade Esophageal Squamous Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal squamous epithelium.


Extramedullary Disease in Plasma Cell Myeloma Involving the Liver

Infiltration of the hepatic sinusoids by malignant (clonal) plasma cells in patients with history of plasma cell myeloma.


Grade 4 Cecal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Urostomy Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Grade 3 Lipohypertrophy, CTCAE

Covering >30% BSA and associated tenderness and narcotics or NSAIDs indicated; lipohypertrophy; limiting self care ADL


Percentage Body Weight Gain

The amount of weight gained over a period of time in relation to the total weight.


A secondary amino compound that is ammonia in which nitrogen is substituted by a 1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl group and a 2-(2-ethoxyphenoxy)ethyl group.


Stage IIIA Gastric Gastrointestinal Stromal Tumor

Stage IIIA includes: T3, N0, M0, Mitotic rate: High. T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Sulfate

A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.


Long-Term Effects Secondary to Cancer Therapy in Adults

Side effects of cancer treatment received during adulthood occurring a long time after the treatment was completed.


Hemangioendothelioma, benign

A benign vascular proliferation characterized by the presence of prominent endothelial cells and the formation of vascular channels.


Grade 3 Mania, CTCAE

Severe manic symptoms (e.g., hypomania; major sexual or financial indiscretions); hospitalization not indicated; new onset


Mania, CTCAE

A disorder characterized by excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood.


Grade 4 Mania, CTCAE

Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Grade 2 Mania, CTCAE

Moderate manic symptoms (e.g., relationship and work difficulties; poor hygiene)


Grade 1 Mania, CTCAE

Mild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep)


Grade 5 Mania, CTCAE

Death


Stage IIIA Rectal Neuroendocrine Tumor AJCC v8

Stage IIIA includes: T4, N0, M0. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colorectal Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a colorectal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to colorectal "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the colon and rectum are not staged using this staging system. (from AJCC 8th Ed.)


Stage I Colorectal Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIB Colon Neuroendocrine Tumor AJCC v8

Stage IIB includes: T3, N0, M0. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIB Rectal Neuroendocrine Tumor AJCC v8


Stage IIIB Colon Neuroendocrine Tumor AJCC v8

Stage IIIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIB Rectal Neuroendocrine Tumor AJCC v8


Rectal Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a rectal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to rectal "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the rectum are not staged using this staging system. (from AJCC 8th Ed.)


Stage IIB Colorectal Neuroendocrine Tumor AJCC v8


Stage IIA Colorectal Neuroendocrine Tumor AJCC v8

Stage IIA includes: T2, N0, M0. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIA Rectal Neuroendocrine Tumor AJCC v8


Colon Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a colon neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to colon "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the colon are not staged using this staging system. (from AJCC 8th Ed.)


Stage IIIB Colorectal Neuroendocrine Tumor AJCC v8


Stage I Colon Neuroendocrine Tumor AJCC v8


Stage IIIA Colon Neuroendocrine Tumor AJCC v8


Stage IIA Colon Neuroendocrine Tumor AJCC v8


Stage IIIA Colorectal Neuroendocrine Tumor AJCC v8


Grade 1 Cardiac Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Cardiac Disorders - Other, Specify, CTCAE


Grade 2 Cardiac Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 5 Cardiac Disorders - Other, Specify, CTCAE

Death


Grade 3 Cardiac Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 4 Cardiac Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Phosphaturic mesenchymal tumor, malignant

A phosphaturic mesenchymal tumor characterized by the presence of nuclear atypia, high mitotic activity, increased cellularity, marked pleomorphism, and necrosis. It usually develops in lesions that have recurred locally and metastasizes to other sites.


Metastatic malignant neoplasm to trachea

A malignant neoplasm that has spread to the trachea from another anatomic site.


Grade 1 Ejaculation Disorder, CTCAE

Diminished ejaculation


Ejaculation Disorder, CTCAE

A disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation.


Grade 2 Ejaculation Disorder, CTCAE

Anejaculation or retrograde ejaculation


Grade 4 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Bilateral Synchronous Sporadic Renal Cell Carcinoma

Non-hereditary renal cell carcinoma arising from a kidney and detected in the other kidney within six months of the first primary. The majority are clear cell renal cell carcinomas.


Kidney Germ Cell Tumor

A rare benign or malignant germ cell tumor that arises from the kidney.


Grade 3 Sinus Pain, CTCAE

Severe pain; limiting self care ADL


paraben

A 4-hydroxybenzoate ester in which the esterifying alcohol is an alkanol (in diagram, R = alkyl). Commonly used as preservatives in cosmetic and pharmaceutical products.


Arteriovenous graft thrombosis

Partial or complete occlusion of the lumen of an arteriovenous graft by a thrombus.


Grade 5 Epistaxis, CTCAE

Death


Grade 3 Trismus, CTCAE

Decreased ROM with inability to adequately aliment or hydrate orally


Refractory Childhood Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia that occurs in childhood and does not respond to treatment.


Childhood Acute Basophilic Leukemia

An acute basophilic leukemia occurring in children.


Sinonasal Solitary Fibrous Tumor

A solitary fibrous tumor that arises from the nasal cavity and paranasal sinuses.


Supernumerary Hemivertebra

More than the usual or expected number of hemivertebra.


Malignant neoplasm of hypopharynx recurrent

The reemergence of a hypopharyngeal malignant neoplasm after a period of remission.


Benign neoplasm of pyriform sinus

A non-metastasizing neoplasm that arises from the pyriform sinus.


Neoplasm of pyriform sinus

A benign or malignant neoplasm that affects the pyriform sinus.


COVID-19-Associated Anosmia

Anosmia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Grade 3 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Tentorial tear due to birth trauma

Pertaining to tears involving the tentorium of the cerebellum.


Grade 4 Stoma Pulmonary Hemorrhage, CTCAE


Resectable Carcinoma

Carcinoma that is amenable to surgical resection.


Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that is amenable to surgical resection.


Carcinoma duodenum resectable

Carcinoma of the duodenum amendable to surgical removal.


Resectable Periampullary Adenocarcinoma

Periampullary adenocarcinoma that is amenable to surgical removal.


Resectable Digestive System Carcinoma

Digestive system carcinoma that is amenable to surgical resection.


Resectable Skin Squamous Cell Carcinoma

Skin squamous cell carcinoma that is amenable to surgical resection.


Localized Resectable Adult Liver Carcinoma

A localized hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and it is amenable to surgical resection.


Resectable Head and Neck Squamous Cell Carcinoma

Squamous cell carcinoma of the head and neck which is amendable to surgical removal.


Resectable Skin Carcinoma

Skin carcinoma that is amenable to surgical resection.


Small intestine carcinoma resectable

Carcinoma of the small intestine amendable to resection.


Resectable Colon Carcinoma

Colon carcinoma that is amenable to surgical resection.


Localized Resectable Adult Hepatocellular Carcinoma

A localized hepatocellular carcinoma that occurs during adulthood and it is amenable to surgical resection.


Carcinoma liver resectable

A hepatocellular carcinoma that is amenable to surgical resection.


Borderline Resectable Carcinoma

A carcinoma term that refers to a continuum between resectable and locally advanced unresectable disease.


Resectable Colorectal Carcinoma

Colorectal carcinoma that is amenable to surgical resection.


Resectable Liver and Intrahepatic Bile Duct Carcinoma

Liver and intrahepatic bile duct carcinoma that is amenable to surgical resection.


Resectable Bladder Urothelial Carcinoma

Bladder urothelial carcinoma that is amenable to surgical resection.


Gastric Xanthoma

A xanthoma located in the stomach.


Grade 1 Scalp Pain, CTCAE

Mild pain


Childhood Cerebellar Anaplastic Astrocytoma

A cerebellar anaplastic astrocytoma that occurs during childhood.


Recurrent Childhood Cerebellar Astrocytoma

Regrowth of benign and malignant childhood cerebellar astrocytomas that have previously been subjected to surgical resection and less frequently other forms of therapy such as radiation or chemotherapy.  Recurrence of benign tumors (e.g., (pilocytic astrocytoma) may respond to a second surgical procedure.


Grade 2 Oral Cavity Pulmonary Fistula, CTCAE


Stage II Lip Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Lower Gingival Verrucous Carcinoma

A verrucous carcinoma of the oral cavity that arises from the lower gingiva.


Verrucous carcinoma of the oral cavity recurrent

Reemergence of verrucous carcinoma of the oral cavity after a period of remission.


Buccal Mucosa Verrucous Carcinoma

A verrucous carcinoma of the oral cavity that arises from the buccal mucosa.


Oral Cavity Carcinoma Cuniculatum

A variant of well-differentiated squamous cell carcinoma arising from the oral cavity. It is characterized by the presence of minimal cytological atypia, multiple keratin-filled crypts, and intraepithelial neutrophils.


Upper Gingival Verrucous Carcinoma

A verrucous carcinoma of the oral cavity that arises from the upper gingiva.


Positive Laboratory Test Result

A laboratory test result that indicates that a specific disease, condition, or attribute being assessed is present.


Human Immunodeficiency Virus 1 Positive

Indicates that human immunodeficiency virus 1 has been detected in a sample.


Progesterone Receptor Positive by Immunohistochemistry

An immunohistochemical staining finding indicating that cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 1-9 Percent

An immunohistochemical staining finding indicating that between 1 and 9 percent of the cells in a tissue sample are expressing progesterone receptor.


Disseminated Tumor Cells Positive

An indication that single tumor cells or small clusters of tumor cells have been detected in a tissue sample.


Progesterone Receptor Positive by Immunohistochemistry 81-90 Percent

An immunohistochemical staining finding indicating that 81-90 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Status 3+

An immunohistochemical result of 3 for progesterone receptor expression that is considered positive for expression.


Hormone Receptor Positive

A finding indicating that the neoplastic cells in a tissue sample test positive for estrogen and/or progesterone receptors.


Progesterone Receptor Positive by Immunohistochemistry 51-60 Percent

An immunohistochemical staining finding indicating that 51-60 percent of the cells in a tissue sample are expressing progesterone receptor.


Expression Positive

An indication that the expression of a gene, transcript or protein has been detected in a sample.


Progesterone Receptor Positive by Immunohistochemistry Less than 1 Percent

An immunohistochemical staining finding indicating that less than 1 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 91-100 Percent

An immunohistochemical staining finding indicating that 91-100 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 21-30 Percent

An immunohistochemical staining finding indicating that 21-30 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 71-80 Percent

An immunohistochemical staining finding indicating that 71-80 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 41-50 Percent

An immunohistochemical staining finding indicating that 41-50 percent of the cells in a tissue sample are expressing progesterone receptor.


Rearrangement Detected

An indication that a cytogenetic rearrangement was detected in a sample.


Progesterone Receptor Positive by Immunohistochemistry 31-40 Percent

An immunohistochemical staining finding indicating that 31-40 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 61-70 Percent

An immunohistochemical staining finding indicating that 61-70 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 1-10 Percent

An immunohistochemical staining finding indicating that 1-10 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 11-20 Percent

An immunohistochemical staining finding indicating that 11-20 percent of the cells in a tissue sample are expressing progesterone receptor.


Refractory Hairy Cell Leukemia Variant

Hairy cell leukemia variant that is resistant to treatment.


HHV-8-Associated Multicentric Castleman Disease

A systemic form of angiofollicular hyperplasia associated with HHV8 infection.


Sellar Chondroid Chordoma

A chondroid chordoma that arises from the sellar region.


Conventional Chordoma

A malignant bone tumor arising from the remnants of the fetal notochord. It is characterized by the presence of large epithelioid cells with clear to light eosinophilic cytoplasm. Some of the cells are large with bubbly, vacuolated cytoplasm (physaliphorous cells). The cells form cords and nests that are embedded within an extracellular myxoid matrix.


Grade 1 Abducens Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


An adenocarcinoma that arises from the sinonasal tract. It is characterized by the absence of features that resemble intestinal adenocarcinoma.


Recurrent Malignant Mastocytosis

The reemergence of malignant mastocytosis after a period of remission.


Psychogenic Musculoskeletal Chest Pain with Dysfunctional Breathing

A condition in which there is musculoskeletal chest pain associated with inappropriate hyperpnea or tachypnea. (ACC/AHA)


Psychogenic Musculoskeletal Chest Pain

A condition in which there is the sensation of musculoskeletal chest pain due to a conversion disorder. (ACC/AHA)


Sellar Gangliocytoma

A tumor that arises in the sellar region and is characterized by the presence of mature ganglion cells and neuronal differentiation. It is often associated with the presence of pituitary neuroendocrine tumors/adenomas.


Double-Negative Prostate Carcinoma

A metastatic, castration-resistant prostate carcinoma that is composed of fibroblast growth factor-driven malignant cells.


Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents

Castration-resistant prostate carcinoma which is refractory to second-generation androgen receptor axis-targeted agents, namely abiraterone and enzalutamide.


Intermediate Atypical Prostate Carcinoma

An aggressive, castration-resistant, histologically distinct, metastatic carcinoma arising from the prostate gland. It is characterized by the presence of a pure population of cytologically bland malignant epithelial cells with moderate to abundant cytoplasm and rare mitotic figures. The prognosis is poor.


Aggressive Variant Prostate Carcinoma

A lethal form of advanced castration-resistant prostate carcinoma that emerges in the later stages of castration-resistant treatment. It is an adaptive response to androgen receptor pathway inhibition. The morphologic features vary, ranging from poorly differentiated carcinomas to mixed adenocarcinoma-small cell carcinomas to pure small cell carcinomas expressing neuroendocrine markers. Clinically, it manifests with rapidly progressive disease, visceral or lytic bone metastases and bulky tumor masses. Molecular studies have shown the loss of tumor suppressor genes TP53 and RB1.


Grade 4 Pericardial Effusion, CTCAE

Life-threatening consequences; urgent intervention indicated


Advanced Unfavorable Hodgkin Lymphoma

An advanced Hodgkin lymphoma with unfavorable prognosis.


allylamine antifungal drug

An organonitrogen compound that contains an amino group that is attached to a carbon which is itself attached to an olefinic carbon and which has been used as an antifungal drug.


Situs inversus thoracis

A congenital condition in which there is complete right-to-left reversal of the position of the thoracic organs.


Urethritis Glandularis

A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by metaplastic glandular cells.


magnesium oxide nanocrystal

A nanocrystal composed of magnesium oxide.


Dialysis Catheter Tunnel Infection

Local infection involving the subcutaneously tunneled portion of a dialysis catheter.


Grade 4 Stevens-Johnson Syndrome, CTCAE

Skin sloughing covering 10-30% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment)


Grade 4 Gastrointestinal Stoma Hemorrhage, CTCAE


Lugano Classification Stage IV Adult Hodgkin Lymphoma AJCC v8

Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the CSF, bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


Lugano Classification Stage IV Adult Lymphoma AJCC v8


Grade 2 Musculoskeletal Deformity, CTCAE

Deformity, hypoplasia, or asymmetry able to be remediated by prosthesis (e.g., shoe insert) or covered by clothing


Pelvic Infection, CTCAE

A disorder characterized by an infectious process involving the pelvic cavity.


Grade 3 Pelvic Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Pelvic Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 5 Pelvic Infection, CTCAE

Death


Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Grade 3 Middle Ear Intra-Operative Injury, CTCAE


Grade 3 Superficial Soft Tissue Fibrosis, CTCAE

Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL


Astrocytoma, Not Otherwise Specified

A central nervous system tumor with morphological features of astrocytoma in which there is insufficient information on the IDH genes status.


Grade 1 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Ciliary Body Benign Teratoid Medulloepithelioma

A rare, unilateral, benign embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium and contains heterologous elements, particularly cartilage, skeletal muscle, and brain tissue.


Recurrent Extragonadal Seminoma

The reemergence of extragonadal seminoma after a period of remission.


Recurrent Malignant Extragonadal Germ Cell Tumor

The reemergence of malignant extragonadal germ cell tumor after a period of remission.


Recurrent Malignant Extragonadal Nongerminomatous Germ Cell Tumor

The reemergence of a malignant extragonadal nongerminomatous germ cell tumor after a period of remission.


Stage IA Cervical Cancer FIGO 2018

Invasive cervical carcinoma that can be diagnosed only by microscopy, with maximum depth of invasion less than 5 mm. (FIGO 2018)


Stage IA2 Cervical Cancer FIGO 2018

Cervical carcinoma with measured stromal invasion equal or more than 3 mm and less than 5 mm in depth. (FIGO 2018)


Stage IA1 Cervical Cancer FIGO 2018

Cervical carcinoma with measured stromal invasion less than 3 mm in depth. (FIGO 2018)


Quinoxaline

A naphthyridine in which the nitrogens are at positions 1 and 4.


Grade 3 Vagina Stricture or Stenosis, CTCAE


Stage I Pancreatic Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor limited to the pancreas and measuring less than 2 cm. N0: No regional lymph node involvement. M0: No distant metastasis. (AJCC 8th ed.)


Infiltrating Intramuscular Lipoma

An infiltrating lipoma that affects skeletal muscle.  It has a higher rate of local recurrence.


Refractory Endometrial Dedifferentiated Carcinoma

Endometrial dedifferentiated carcinoma that is resistant to treatment.


Campylobacter jejuni infection

An infection that is caused by Campylobacter jejuni.


Small Intestinal Infection

An infectious process affecting the small intestine.


Duodenal Infection

An infectious process affecting the duodenum.


Stage IVB Rectal Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis.  (AJCC 8th ed.)


Cervical Mucinous Adenocarcinoma, Not Otherwise Specified

A cervical mucinous adenocarcinoma in which more than 50% of malignant cells contain intracytoplasmic mucin. There is no evidence of gastric, intestinal, or signet ring cell differentiation.


glycerolipid

Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.


triradylglycerol

A glycerol compound having one of three possible substituent groups - either acyl, alkyl, or alk-1-enyl - at each of the three possible positions sn-1, sn-2 or sn-3. has functional parent glycerol (CHEBI:17754), children: triglyceride (CHEBI:17855). Parent: is_a glycerolipid (CHEBI:35741)


glyceride

Any ester resulting from the condensation of one or more of the hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl substituents at positions 1 and 2 are specified as gamma-linolenoyl and oleoyl respectively.


glycerophospholipid

Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.


Triglyceride

Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


Grade 3 Joint Infection, CTCAE

Arthroscopic intervention indicated (e.g., drainage) or arthrotomy (e.g., open surgical drainage)


Grade II Prostatic Intraepithelial Neoplasia

High grade prostatic intraepithelial neoplasia characterized by the presence of moderate architectural and cytologic abnormalities.


Testicular Tumor of the Thecoma/Fibroma Group

A group of rare, slow-growing stromal tumors that arise from the testis.  This category includes thecoma and fibroma.


Testicular Signet Ring Stromal Tumor

An extremely rare tumor that arises from the testis. It is characterized by the proliferation of epithelioid cells with signet ring appearance separated by fibrous tissue into trabeculae and nests. The histologic features are bland and there is no mucin production. Mutations of CTNNB1 gene have been identified in the reported cases. It is considered a special type of sex cord-stromal tumor. All reported cases had a benign clinical course without metastases.


recurrent childhood acute myeloid leukemia

The reemergence of acute myeloid leukemia in childhood after a period of remission.


Grade 4 Uterine Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Childhood Unfavorable Prognosis Hodgkin Lymphoma

A Hodgkin lymphoma with unfavorable prognosis that occurs during childhood.


Acquired Factor III Deficiency

An acquired coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Factor III deficiency

A coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Factor III Inactivation

Presence of inactivating antibodies to tissue factor (factor III) in the blood.


Hereditary Factor III Deficiency

An autosomal recessive, inherited coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Grade 4 Nodal or Junctional Rhythm, CTCAE


Acardius

A severe form of twin-twin transfusion syndrome that occurs in monochorionic pregnancies. The normal twin (pump twin) supplies the blood flow to its sibling that lacks heart or brain or both (acardiac/acephalic twin). Untreated, it may lead to the demise of the pump twin in some cases.


Suture Abrasion

Wearing away of the surface of a suture as a result of bending and frictional forces.


skin abrasion

Superficial damage to the skin caused by rubbing or scraping.


Grade 5 Necrotizing Enterocolitis, AE

A necrotizing enterocolitis adverse event in a newborn which results in death.


Grade 3 Jugular Vein Intra-Operative Injury, CTCAE


Benign neoplasm of supraglottis

A non-metastasizing neoplasm that arises from the supraglottis.


Childhood Acute Myeloid Leukemia without Maturation

An acute myeloid leukemia without maturation occurring in children.


Grade 3 Tracheal Fistula, CTCAE

Invasive intervention indicated


Pulmonary and Upper Respiratory Fistula, CTCAE


Grade 3 Laryngeal Fistula, CTCAE

Invasive intervention indicated


Grade 1 Oral Cavity Pulmonary Fistula, CTCAE


Grade 2 Laryngeal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 3 Oral Cavity Pulmonary Fistula, CTCAE


Laryngeal Fistula, CTCAE

A disorder characterized by an abnormal communication between the larynx and another organ or anatomic site.


Grade 4 Pharynx Pulmonary Fistula, CTCAE


Grade 4 Oral Cavity Pulmonary Fistula, CTCAE


Tracheal Fistula, CTCAE

A disorder characterized by an abnormal communication between the trachea and another organ or anatomic site.


Grade 5 Laryngeal Fistula, CTCAE

Death


Grade 5 Oral Cavity Pulmonary Fistula, CTCAE


Grade 5 Pharynx Pulmonary Fistula, CTCAE


Grade 3 Pharynx Pulmonary Fistula, CTCAE


Grade 1 Laryngeal Fistula, CTCAE

Asymptomatic


Grade 1 Tracheal Fistula, CTCAE

Asymptomatic


Grade 2 Pharynx Pulmonary Fistula, CTCAE


Grade 1 Pharynx Pulmonary Fistula, CTCAE


Parasite-Related Carcinoma

A term that refers to a group of carcinomas that are caused by parasites.


Schistosoma Hematobium-Related Bladder Squamous Cell Carcinoma

A squamous cell carcinoma of the bladder that is caused by Schistosoma hematobium.


Schistosoma Hematobium-Related Bladder Verrucous Carcinoma

A verrucous squamous cell carcinoma of the bladder that is caused by Schistosoma hematobium.


BCLC Stage 0 Adult Hepatocellular Carcinoma

Very early hepatocellular carcinoma. Patients are optimal candidates for resection. (HPB (Oxford) 2005; 7(1):35-41)


Metastatic malignant neoplasm to choroid

A malignant neoplasm that has spread to the choroid from another anatomic site.


Gallbladder Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the gallbladder.


Maxillofacial Chondroblastoma

A benign chondroid-producing neoplasm arising in a maxillofacial bone.


Osteochondromyxoma

A rare benign chondroid and osteoid matrix-producing neoplasm of bone characterized by extensive myxoid changes.  It may be a locally destructive neoplasm and has been reported in patients with Carney complex.


Laryngeal Chondroma

A benign neoplasm arising from hyaline cartilage of the larynx. It is characterized by the presence of chondrocytes, a lobulated growth pattern, and calcification.


Maxillofacial Chondroma

A benign neoplasm of hyaline cartilage that arises within the medullary cavity of a maxillofacial bone. It is characterized by the presence of chondrocytes, a lobulated growth pattern, and calcification.


Maxillofacial Chondromyxoid Fibroma

An uncommon benign cartilaginous neoplasm arising in a maxillofacial bone. It is characterized by the presence of spindle-shaped or stellate chondrocytes, a lobulated growth pattern, myxoid stroma formation, and sometimes multinucleated giant cells.


Chondromatosis

A multifocal benign neoplasm arising from bone or soft tissue.  It is characterized by the presence of chondrocytes and is composed of hyaline cartilage.


Bizarre parosteal osteochondromatous proliferation

A benign lesion that usually affects the proximal small bones of the hands or feet.  Grossly it consists of a cartilage cap and a bony stalk.  Microscopically it is characterized by the presence of spindle cells, cartilage, and bone, usually in a disorganized pattern compared to subungual exostosis.  Enlarged (bizarre) chondrocytes are present in the cartilage.  Swelling with or without pain is present.  Recurrences following resection have been reported in approximately half of cases.


Solitary Osteochondroma

An osteochondroma affecting a single anatomical site.


hemisuccinate

A succinate ester in which only one of the carboxy groups of succinic acid has been esterified.


Tactile Disorder

Conditions characterized by an alteration in the ability to perceive touch.


Uterine Obstruction

Blockage of the uterine outlet. Causes include uterine tumors and adhesions.


Refractory Lymphoma

A lymphoma that does not respond to treatment.


Hodgkin's disease lymphocyte depletion type refractory

Lymphocyte-depleted classic Hodgkin lymphoma that is resistant to treatment.


Refractory B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma

B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma that is resistant to treatment.


Refractory Central Nervous System Lymphoma

Central nervous system lymphoma that is resistant to treatment.


Refractory Primary Cutaneous Lymphoma

Primary cutaneous lymphoma that does not respond to treatment.


Refractory EBV-Related Lymphoma

EBV-related lymphoma that is resistant to treatment.


Hodgkin's disease mixed cellularity refractory

Mixed cellularity classic Hodgkin lymphoma that is resistant to treatment.


Classical Hodgkin lymphoma refractory

Classic Hodgkin lymphoma that is resistant to treatment.


Refractory Primary Bone Lymphoma

Primary lymphoma of bone that is resistant to treatment.


Refractory Hodgkin Lymphoma

Hodgkin lymphoma resistant to treatment


Hodgkin's disease nodular sclerosis refractory

Nodular sclerosis classic Hodgkin lymphoma that is resistant to treatment.


Refractory Nodular Lymphocyte Predominant Hodgkin Lymphoma

Nodular lymphocyte predominant Hodgkin lymphoma that is resistant to treatment.


Refractory Lymphocyte-Rich Classic Hodgkin Lymphoma

Lymphocyte-rich classic Hodgkin lymphoma that does not respond to treatment.


Laryngeal Neuroendocrine Tumor G1

A well-differentiated, low grade neuroendocrine neoplasm that arises from the larynx.


Head and Neck Neuroendocrine Tumor

A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the head and neck.


Head and Neck Neuroendocrine Tumor G2

A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the head and neck.


Laryngeal Neuroendocrine Tumor

A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the larynx.


Head and Neck Neuroendocrine Tumor G1

A well-differentiated, low grade neuroendocrine neoplasm that arises from the head and neck.


Laryngeal Neuroendocrine Tumor G2

A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the larynx.


Post abortion hemorrhage

Excessive bleeding occurring after spontaneous miscarriage or therapeutic abortion.


Grade 4 Intestinal Stoma Obstruction, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Vitamin D4

It is present in mushrooms.


1alpha,25-dihydroxy-22-oxavitamin D3 3-hemiglutarate/1alpha,25-dihydroxy-22-oxacholecalciferol 3-hemiglutarate


previtamin D3

A hydroxy seco-steroid which is an intermediate in the production of vitamin D3 in human skin.


23(S),25-dihydroxy-24-oxovitamin D3

A hydroxycalciol that is 25-hydroxyvitamin D3 carrying an additional hydroxy group at position 23 (with 23S-configuration) and an oxo group at position 24. An intermediate in the degradation pathway of 25-OH-vitamin D3.


(20S,24S)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 and 24 (both with S-configuration).


(5Z)-1alpha,25-dihydroxy-3-deoxy-3-thiavitamin D3 3-oxide/(5Z)-1alpha,25-dihydroxy-3-deoxy-3-thiacholecalciferol 3-oxide


calcidiol 3-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 3 has been replaced by a beta-D-glucuronyl residue.


1,24(S)-Dihydroxyvitamin D2

Metabolite of vitamin D2. It  present in the circulation of humans, cows, and rats given pharmacologic doses of vitamin D2


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity.


(20S)-hydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying an additional hydroxy group at position 20 with S-configuration.


A hydroxycalciol that is calciol with an additional hydroxy group at position C-1 and an acetoxy group at C-18.


(20S,23)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 23.


1alpha-hydroxy-25,26,27-trinorvitamin D3 24-carboxylic acid


(23S,25R)-25-hydroxyvitamin D3 26,23-lactol/(23S,25R)-25-hydroxycholecalciferol 26,23-lactol


Vitamin D5

A vitamin D in which the side-chain at position 17 consists of a (5R)-5-ethyl-6-methylheptan-2-yl group.


1alpha,25-Dihydroxyvitamin D3 25-trimethylsilyl ether


1alpha,2beta,25-trihydroxy vitamin D3

A hydroxy seco-steroid that is calciol carrying three additional hydroxy substituents at positions 1alpha, 2beta and 25.


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity


D3 vitamins

A vitamin D that is calciol or its hydroxylated metabolites calcidiol and calcitriol. Calciol (also known as vitamin D3) acts as a hormone precursor, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.


A hydroxycalciol that is calcitriol with an acetoxy group at C-18.


25-Hydroxyvitamin D2

A hydroxycalciol that is vitamin D2 in which the hydrogen at position 25 has been replaced by a hydroxy group.


5,6-trans-Vitamin D3

A member of the class of D3 vitamins that is calciol in which the double bond at position 5 adopts a trans-configuration. During exposure to sunlight, previtamin D3 and vitamin D3 in the skin become photoisomerized to 5,6-trans-vitamin D3.


(20S,24R)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration) and 24 (with R-configuration).


20(S),25-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 25.


Ercalcitriol

A hydroxycalciol that is vitamin D2 bearing additional hydroxy substituents at positions 1alpha and 25.


A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 25 has been replaced by a beta-D-glucuronyl residue.


Grade 2 Jejunal Obstruction, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Grade 2 Head Soft Tissue Necrosis, CTCAE

Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Splenic Plasmacytoma

A plasmacytoma that arises in the spleen.


Splenic B-Cell Lymphoma/Leukemia, Unclassifiable

A small B-cell clonal lymphoproliferative disorder of the spleen that does not fall into any of the other categories of mature B-cell neoplasms.


Extramedullary Disease in Plasma Cell Myeloma Involving the Spleen

Infiltration of the spleen by malignant (clonal) plasma cells in patients with history of plasma cell myeloma


Malignant Splenic Soft Tissue Neoplasm

A malignant soft tissue neoplasm that arises from the spleen.


Recurrent Hairy Cell Leukemia Variant

The reemergence of hairy cell leukemia variant after a period of remission.


Splenic Manifestation of Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Infiltration and expansion of the red pulp and sinusoids of the spleen by chronic myelogenous leukemia, BCR-ABL1 positive.


Splenic Manifestation of B-Cell Prolymphocytic Leukemia

Infiltration and expansion of the white and red pulp of the spleen by B-cell prolymphocytic leukemia.


Splenic Manifestation of T-Cell Prolymphocytic Leukemia

Infiltration and expansion of the white and red pulp of the spleen by T-cell prolymphocytic leukemia.


Malignant lymphoma of spleen

A non-Hodgkin lymphoma or rarely Hodgkin lymphoma that arises from the spleen.


Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia

Infiltration and expansion of the red pulp cords and sinusoids of the spleen by T-cell large granular lymphocyte leukemia. The white pulp of the spleen is not involved and is often hyperplastic.


thiazolidinediones

A thiadiazolidine in which the 1,3-thiazolidine ring is substituted by two oxo groups.


Paratesticular Paraganglioma

An extremely rare paraganglioma that arises from the paratesticular structures.


Myeloid Neoplasms with Germline Predisposition Associated with Other Organ Dysfunction

Familial myeloid neoplasms associated with germline mutations and a preexisting disorder or organ dysfunction other than a platelet disorder.


Myeloid Neoplasms with Germline Predisposition Associated with Inherited Bone Marrow Failure Syndromes

Familial myelodysplastic syndromes/ acute myeloid leukemias associated with inherited bone marrow failure syndromes.


Myeloid Neoplasms with Germline Predisposition Associated with Telomerase Biology Disorders

Familial myelodysplastic syndromes/ acute myeloid leukemias associated with telomerase biology disorders.


Myeloid Neoplasms with Germline GATA2 Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline GATA2 mutation.


Myeloid Neoplasms with Germline SAMD9 Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9 mutation.


Myeloid Neoplasms with Germline SAMD9L Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9L mutation.


Serous Tubal Intraepithelial Lesion

A non-invasive, precursor epithelial proliferation that arises from the fallopian tube, lacks severe atypia, and demonstrates serous differentiation.


Fracture of Ulna Related to Birth

A broken ulna sustained during the birthing process.


Closed Monteggia's fracture

Proximal radial head dislocation in association with a proximal ulnar fracture that does not involve a break in the adjacent skin.


Fracture of Clavicle Related to Birth

An injury sustained during the birthing process in which the continuity is broken in the clavicle.


Fracture of Femur Related to Birth

A broken femur sustained during the birthing process.


Closed fracture of rib

A traumatic break in one of the bones in the rib cage that does not involve a break in the adjacent skin.


Fracture of metacarpal bone

A traumatic break in one or more of the metacarpal bones.


Closed fracture of shaft of metacarpal bone

A traumatic break in the diaphysis of the metacarpal bone that does not involve a break in the adjacent skin.


Closed fracture of multiple ribs

A traumatic break in two or more places in one rib, or a traumatic break in more than one rib, that does not involve a break in the adjacent skin.


Closed fracture of pelvis

A traumatic break in one or more of the bones comprising the bony structure of the pelvis that does not involve a break in the adjacent skin.


Open fracture of rib

A traumatic break in one of the bones in the rib cage  that involves a break in the adjacent skin.


Closed fracture of metacarpal bone

A traumatic break in one or more of the metacarpal bones that does not involve a break in the adjacent skin.


Fracture of mandible, closed

A traumatic break in the mandible  that does not involve a break in the adjacent skin.


Closed fracture of malar AND/OR maxillary bones

A traumatic break in the malar and maxillary bones  that does not involve a break in the adjacent skin.


Fracture Related to Birth

A broken bone sustained during the birthing process.


Closed fracture of neck of metacarpal bone

A traumatic break in the area of the metacarpal bone located between the diaphysis and the distal metaphysis that does not involve a break in the adjacent skin.


Fracture of bone involving growth plate

A traumatic break in a long bone that involves the epiphyseal plate.


Lumbar vertebral fracture L2

A traumatic break in the second lumbar spinal vertebra.


Fracture of Humerus Related to Birth

A broken humerus sustained during the birthing process.


Fracture of phalanx of finger

A traumatic break in one or more of the bones in one of the digits of the hand.


Open fracture of neck of metacarpal bone

A traumatic break in the area of the metacarpal bone located between the diaphysis and the distal metaphysis that involves a break in the adjacent skin.


Closed Colles' fracture

An extra-articular traumatic break in the distal radius with dorsal displacement of the distal fragment that does not involve a break in the adjacent skin.


Fracture of Spine Related to Birth

A broken vertebra sustained during the birthing process.


Fracture of Radius Related to Birth

A broken radius sustained during the birthing process.


Colles' Fracture

An extra-articular traumatic break in the distal radius with dorsal displacement of the distal fragment.


Open fracture of pelvis

A traumatic break in one or more of the bones comprising the bony structure of the pelvis that involves a break in the adjacent skin..


Fracture of Skull Related to Birth

An injury sustained during the birthing process in which the continuity is broken in the skull.


Limb fracture

A traumatic break in one or more bones in a limb.


Open fracture of metacarpal bone

A traumatic break in one or more of the metacarpal bones that involves a break in the adjacent skin.


Fracture of Nose Related to Birth

A broken nasal bone sustained during the birthing process.


Grade 2 Vaginal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Parotid Gland Lymphangioma

A lymphangioma arising from the parotid gland.


dichlorobenzene

Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.


Isoconazole

A member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1.


(S)-fenticonazole

A 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole that is the (S)-enantiomer of fenticonazole.


A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of econazole.


(S)-butoconazole

The (S)-enantiomer of butoconazole.


(S)-Tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of tioconazole.


A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of econazole.


clonidine (amino form)

A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.


Fenticonazole, (R)-

A 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole that is the (R)-enantiomer of fenticonazole.


(S)-Miconazole

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has S) configuration.


(S)-Enilconazole

A 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that is the (S)-enantiomer of enilconazole


(R)-Enilconazole

A 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that is the (R)-enantiomer of enilconazole.


Arasertaconazole

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the active R-enantiomer of sertaconazole and is used (as its nitrate salt) for treatment of vulvovaginal candidiasis. The racemate itself is also used as a broad-spectrum antifungal drug.


(R)-butaconazole

The (R)-enantiomer of butaconazole.


(R)-Miconazole

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has R configuration.


A salicylanilide derivative with chloride substituents at C-3 and C-5 of the salicylate moiety and at C-3 and C-4 of the anilide moiety.


(R)-Tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of tioconazole.


(S)-Sertaconazole

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of sertaconazole.


A pyrazolylpiperidine that consists of 4-(pyrazol-1-yl)piperidine carrying a 2-amino-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-5-yl group at the 4-position of the pyrazole ring.


Stage IV Adrenal Cortex Carcinoma AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


A sympathetic paraganglioma arising from the retroperitoneum, outside the adrenal gland.


Retroperitoneal Ganglioneuroma

A ganglioneuroma arising from the retroperitoneum.


Adrenal Cortical Carcinoma by AJCC v7 Stage

A term that refers to the staging of adrenal cortical carcinoma, following the rules of the TNM AJCC v7 classification system.


Adrenal Cortical Oncocytic Carcinoma

A carcinoma that arises from the adrenal cortex and is composed of oncocytic cells that constitute more than 90% of malignant cells.


Stage III Adrenal Cortex Carcinoma AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0); (T4, Any N, M0). T1: Tumor measuring 5 cm or less in greatest dimension, with no extra-adrenal invasion. T2: Tumor measuring more than 5 cm in greatest dimension, with no extra-adrenal invasion. T3: Tumor of any size with local invasion but not invading adjacent organs. T4: Tumor of any size that invades adjacent organs (kidney, diaphragm, pancreas, spleen, or liver) or large blood vessels (renal vein or vena cava). N1: Metastasis in regional lymph node(s). M0: No distant metastasis. (from AJCC 8th Ed.)


Adrenal Cortical Carcinoma by AJCC v8 Stage

A term that refers to the staging of adrenal cortical carcinoma, following the rules of the TNM AJCC v8 classification system. Adrenal medullary pheochromocytoma is staged according to the classification for adrenal neuroendocrine tumors. There is no AJCC staging system for neuroblastic tumors of the adrenal gland. (from AJCC 8th Ed.)


Adrenal Cortical Oncocytic Adenoma

A usually non-functioning variant of adrenal cortex adenoma, composed of large cells with abundant granular eosinophilic cytoplasm.


Glomerulosa Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of neoplastic cells with cytologic features of glomerulosa cells.


Stage III Adrenal Cortex Carcinoma AJCC v7

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0).  T1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion.  T2: Tumor greater than 5 cm, no extra-adrenal invasion.  T3: Tumor of any size with local invasion, but not invading adjacent organs.  N1: Metastasis in regional lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adrenal Gland Ganglioneuroma

A ganglioneuroma arising from the adrenal gland.


Adrenal Gland Lipoma

A rare lipoma that arises from the adrenal gland.


Recurrent Adrenal Gland Pheochromocytoma

The reemergence of pheochromocytoma following surgical removal.


Clear Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of neoplastic clear cells containing intracytoplasmic lipid droplets.


Stage IV Adrenal Cortex Carcinoma AJCC v7

Stage IV includes: (T3, N1, M0); (T4, N0, M0); (T4, N1, M0); (Any T, Any N, M1).  T3: Tumor of any size with local invasion, but not invading adjacent organs.  T4: Tumor of any size with invasion of adjacent organs.  N1: Metastasis in regional lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. M1: Distant metastasis.  (AJCC 7th ed.)


Retroperitoneal Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor that arises from the retroperitoneum. This is an extragastrointestinal tumor, meaning that it does not arise directly from the gastrointestinal tract.


Leiomyoma of the adrenal gland

A rare leiomyoma that arises from the adrenal gland.


Benign neoplasm of retroperitoneum

A non-metastasizing neoplasm that arises from the retroperitoneum.


Benign neoplasm of adrenal cortex

A non-metastasizing neoplasm arising from the adrenal cortex.


Stage I Adrenal Cortex Carcinoma AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Familial Adrenal Gland Pheochromocytoma

A familial adrenal gland pheochromocytoma caused by mutations in SDHB, SDHC, and SDHD genes.


Adrenal Cortical Adenomatoid Tumor

A benign adrenal cortical neoplasm deriving from mesothelial cells.


Locally Advanced Adrenal Gland Pheochromocytoma

Adrenal gland pheochromocytoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adrenal Cortical Myxoid Carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the presence of abundant extracellular connective tissue mucin.


Locally Advanced Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adrenal Gland Lymphangioma

A rare lymphangioma that arises from the adrenal gland.


Stage II Adrenal Cortex Carcinoma AJCC v7

Stage II includes: T2, N0, M0.  T2: Tumor greater than 5 cm, no extra-adrenal invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adrenal Gland Lymphoma

A rare lymphoma that arises from the adrenal gland.


Adrenal Cortical Low Grade Carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the presence of twenty or less mitoses per ten square millimeters.


Metastatic Adrenal Gland Composite Pheochromocytoma

An adrenal gland composite pheochromocytoma that metastasizes to other anatomic sites.


Metastatic Adrenal Cortical Carcinoma

A carcinoma that arises from the adrenal cortex and has metastasized to another anatomic site.


Adrenal Gland Hemangioma

A rare hemangioma that arises from the adrenal gland.


Superior and Inferior Paraaortic Paraganglioma

An extra-adrenal sympathetic paraganglioma arising from paraganglia located along the aorta, including suprarenal, infrarenal, and renal hilar sites.  In functional tumors, the hypersecretion of catecholamines results in hypertension.


Metastatic Carcinoma in the Adrenal Cortex

A carcinoma that has spread to the adrenal cortex from an adjacent or distal anatomic site.


Androgen-Producing Adrenal Cortical Adenoma

A rare adenoma of the adrenal cortex that produces androgens.  Female patients usually have symptoms related to virilism.


Unresectable Adrenal Gland Pheochromocytoma

Adrenal gland pheochromocytoma that is not amenable to surgical resection.


Compact Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of neoplastic compact cells with eosinophilic cytoplasm.


Adrenal Cortical Sex Cord-Stromal Tumor

An extremely rare sex cord-stromal tumor that arises from the adrenal cortex. The reported cases were solitary and unilateral.


Adrenal Gland Composite Pheochromocytoma

A neoplasm that arises from the adrenal medulla and combines morphologic characteristics of pheochromocytoma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor.


Adrenal Gland Ganglioneuroblastoma, Intermixed

An intermixed ganglioneuroblastoma arising from the adrenal gland.


Adrenal Cortical High Grade Carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the presence of more than twenty mitoses per ten square millimeters.


Stage I Adrenal Cortex Carcinoma AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor measuring 5 cm or less in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Advanced Adrenal Gland Pheochromocytoma

An adrenal gland pheochromocytoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adrenal Cortical Melanoma

A rare melanoma that arises within the adrenal cortex.


Adrenal Gland Schwannoma

A rare schwannoma that arises from the adrenal medulla.


Mixed Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of a mixed neoplastic cellular population, including varying numbers of neoplastic clear and compact cells.


Stage II Adrenal Cortex Carcinoma AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor measuring more than 5 cm in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Adrenal Gland Ganglioneuroblastoma, Nodular

A nodular ganglioneuroblastoma arising from the adrenal gland.


Unresectable Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that is not amenable to surgical resection.


Recurrent Malignant Retroperitoneal Neoplasm

The reemergence of a malignant retroperitoneal neoplasm after a period of remission.


Non-Metastatic Adrenal Gland Composite Pheochromocytoma

A composite pheochromocytoma that is confined to the adrenal gland.


Regional Adrenal Gland Pheochromocytoma

A pheochromocytoma that has not spread to other regions.


Heavily Pigmented Adrenal Cortical Adenoma

A usually functioning adenoma of the adrenal cortex. Grossly, it has a dark brown appearance and is characterized by the presence of neoplastic cells containing abundant intracytoplasmic lipofuscin. It may be associated with Cushing syndrome.


Recurrent Adrenal Cortical Carcinoma

The reemergence of adrenal cortical carcinoma after a period of remission.


Anaplastic adrenocortical carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the partial or complete loss of adrenal cortical differentiation.


Refractory Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that is resistant to treatment.


estrogen-producing adrenal cortical adenoma

A rare adenoma of the adrenal cortex that produces estrogens.  Male patients may develop gynecomastia and impotence.


Grade 1 Conjunctivitis, CTCAE

Asymptomatic or mild symptoms; intervention not indicated


Grade 5 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Forceps Injury

Birth injury sustained during a forceps-assisted delivery.


Grade 5 Pericardial Tamponade, CTCAE

Death


Grade 1 Upper Extremity Vein Injury, CTCAE


Grade 4 Upper Extremity Vein Injury, CTCAE


Grade 2 Upper Extremity Vein Injury, CTCAE


Grade 5 Upper Extremity Vein Injury, CTCAE


Familial Adenomatous Polyposis Associated Medulloblastoma

A medulloblastoma developing in patients with familiar adenomatous polyposis syndrome.  It is observed in patients with Turcot syndrome, type 2.


Sellar Neuroblastoma

A rare neuroblastoma arising from the sella turcica.


Refractory Ganglioneuroblastoma

Ganglioneuroblastoma that does not respond to treatment.


Embryonal Tumor with Multilayered Rosettes, DICER1-Mutated

An embryonal tumor with multilayered rosettes characterized by the presence of DICER1 mutation. Approximately half of embryonal tumors with multilayered rosettes that lack a C19MC alteration carry DICER1 mutations.


Hepatoblastoma with Pure Fetal Epithelial Differentiation

A hepatoblastoma composed of small cells resembling the fetal hepatocytes, forming thin trabeculae.


Refractory Dedifferentiated Chordoma

A dedifferentiated chordoma that does not respond to treatment.


Familial Neuroblastoma

Genetic inheritance of neuroblastoma caused by mutations in the ALK or PHOX2B genes.  Familial neuroblastomas have a higher incidence of multiple primary tumors and are diagnosed at an earlier age.


Refractory Rhabdoid Tumor

Rhabdoid tumor that does not respond to treatment.


Childhood Central Nervous System Ganglioneuroblastoma

A cerebral ganglioneuroblastoma that occurs during childhood.


Advanced Chordoma

A chordoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Central Nervous System Embryonal Tumor, Not Otherwise Specified with Leptomeningeal Spread

A central nervous system embryonal tumor, not otherwise specified which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.


Visual Pathway Medulloepithelioma

A very rare, benign or malignant embryonal neoplasm affecting the visual pathway during childhood. It arises from primitive medullary epithelium.


PRETEXT Stage 1 Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves only 1 quadrant; 3 adjoining liver quadrants are free of tumor. (from PDQ 2004)


Neuroblastoma of the Adrenal Gland and Sympathetic Nervous System

A common pediatric extracranial tumor arising from neural crest cells.  It involves the adrenal medulla and the sympathetic nervous system.


Prostate Wilms Tumor

A rare Wilms tumor affecting the prostate gland.


Adult Supratentorial Embryonal Tumor, Not Otherwise Specified

A supratentorial embryonal tumor, not otherwise specified that occurs in adults.


Childhood Atypical Teratoid/Rhabdoid Tumor

An atypical teratoid/rhabdoid tumor occurring in children.


medulloblastoma SHH activated and TP53 mutant

Medulloblastoma associated with activation of the sonic hedgehog (SHH) pathway and the presence of TP53 mutations.


An intermixed ganglioneuroblastoma that occurs during childhood.


Anaplastic Medulloblastoma

A medulloblastoma characterized by marked nuclear pleomorphism, and high mitotic activity.


Paratesticular Wilms Tumor

A rare Wilms tumor that arises from the paratesticular structures.


Localized Resectable Neuroblastoma

Neuroblastoma that is confined to a specific site and is amenable to surgical removal.


Refractory Peripheral Primitive Neuroectodermal Tumor

Peripheral primitive neuroectodermal tumor that does not respond to treatment.


Recurrent Rhabdoid Tumor

The reemergence of rhabdoid tumor after a period of remission.


Thyroblastoma

A high-grade, rapidly growing malignant embryonal neoplasm that arises from the thyroid gland. It is characterized by the presence of primitive follicular-like structures surrounded by primitive small cells and primitive spindle cell mesenchymal stroma. It is associated with DICER1 gene mutations. The prognosis is poor.


Extra-osseous Ewing's sarcoma recurrent

Reemergence of extraskeletal Ewing sarcoma after a period of remission.


Peripheral neuroepithelioma of bone metastatic

A small round cell tumor of the bone with neural differentiation that has spread from its original site of growth to another anatomic site.


Unresectable Ewing Sarcoma

A Ewing sarcoma which is not amenable to surgical resection.


Central Nervous System Embryonal Neoplasm

A malignant neoplasm of embryonal origin, arising from the central nervous system.  It usually affects children.  Representative examples include ependymoblastoma, medulloblastoma, and atypical teratoid/rhabdoid tumor.


Postsurgical Stage I Hepatoblastoma

No metastases, tumor completely resected. (from PDQ 2004)


Locally Advanced Ewing Sarcoma

Ewing sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Sellar Dedifferentiated Chordoma

A dedifferentiated chordoma that arises from the sellar region.


Recurrent Childhood Central Nervous System Embryonal Neoplasm

The reemergence of childhood central nervous system embryonal neoplasm after a period of remission.


Resectable Neuroblastoma

Neuroblastoma that is amenable to surgical resection.


Paratesticular Melanotic Neuroectodermal Tumor

A rare neoplasm that arises from the paratesticular structures and is characterized by the presence of a mixture of melanin-containing epithelial cells and smaller neuroblast-like cells. It usually occurs in infants and has a benign clinical course.


High Risk Neuroblastoma

Neuroblastoma usually presenting with metastatic disease and MYCN gene amplifications.


Hepatoblastoma with Combined Fetal and Embryonal Epithelial Differentiation

A hepatoblastoma composed of cells resembling fetal epithelial cells and small round cells resembling blastema cells.


embryonal tumor with multilayered rosettes

A central nervous system embryonal tumor characterized by the presence of multilayered rosette formation and typically the presence of amplification of the C19MC region on chromosome 19 (19q13.42) or rarely a DICER1 mutation.


Peripheral neuroepithelioma of bone recurrent

The reemergence of peripheral primitive neuroectodermal tumor of the bone after a period of remission.


Refractory Atypical Teratoid/Rhabdoid Tumor

An atypical teratoid/rhabdoid tumor that does not respond to treatment.


Cribriform Neuroepithelial Tumor

A very rare, nonrhabdoid, intraventricular tumor with relatively favorable prognosis.  It is characterized by the presence of neuroepithelial cells forming cribriform patterns, trabeculae, epithelial membrane antigen immunopositivity on epithelial surfaces, and loss of nuclear INI 1 expression.


Sellar Chordoma

A chordoma that arises from the sellar region.


The reemergence of medulloblastoma, WNT-activated after a period of remission.


Stage 3 Neuroblastoma

Unresectable unilateral tumor infiltrating across the midline, with or without regional lymph node involvement; or localized unilateral tumor with contralateral regional lymph node involvement; or midline tumor with bilateral extension by infiltration (unresectable) or by lymph node involvement. The midline is defined as the vertebral column. Tumors originating on one side and crossing the midline must infiltrate to or beyond the opposite side of the vertebral column. (cancer.gov)


Stage 4S neuroblastoma

Localized primary tumor, as defined for stage 1, 2A, or 2B, with dissemination limited to skin, liver, and/or bone marrow (limited to infants younger than 1 year). Marrow involvement should be minimal (i.e., <10% of total nucleated cells identified as malignant by bone biopsy or by bone marrow aspirate). More extensive bone marrow involvement would be considered stage 4 disease. The results of the MIBG scan, if performed, should be negative for disease in the bone marrow. (cancer.gov)


Medulloblastoma with Leptomeningeal Spread

A medulloblastoma which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.


Unresectable Rhabdoid Tumor

A rhabdoid tumor that is not amenable to surgical resection.


Stage IV Kidney Wilms Tumor

Wilms tumor that has spread to other more distant organs, such as the lungs, liver, bones, and brain, or to lymph nodes outside the abdomen (National Wilms Tumor Study Group Staging System)


Poorly Differentiated Neuroblastoma

A neuroblastoma in which the differentiating neuroblasts constitute less than five-percent of the tumor cells.


Skin Ewing Sarcoma

A rare Ewing sarcoma that arises from the skin.


Unresectable Chordoma

A chordoma which is not amenable to surgical resection.


Hepatoblastoma recurrent

The reemergence of hepatoblastoma after a period of remission.


Recurrent Atypical Teratoid/Rhabdoid Tumor

The reemergence of an atypical teratoid/rhabdoid tumor after a period of remission.


Hepatoblastoma non-resectable

Hepatoblastoma not amenable to surgical removal.


Regional Neuroblastoma

A neuroblastoma confined to a specific anatomic region without evidence of dissemination.


Ciliary Body Teratoid Medulloepithelioma

A rare, unilateral, benign or malignant embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium and contains heterologous elements, particularly cartilage, skeletal muscle, and brain tissue.


Undifferentiated Neuroblastoma

A neuroblastoma characterized by the absence of differentiating neuroblasts.


Stage 2 Neuroblastoma

Stage 2 includes stage 2A and stage 2B.  Stage 2A: Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph nodes negative for tumor microscopically. Stage 2B: Localized tumor with or without complete gross excision, with ipsilateral nonadherent lymph nodes positive for tumor. Enlarged contralateral lymph nodes must be negative microscopically. (cancer.gov)


Locally Advanced Chordoma

A chordoma that has spread from its original site of growth to nearby tissues.


Postsurgical Stage III Hepatoblastoma

No distant metastases, tumor unresectable or resected with gross residual tumor, or positive lymph nodes. (from PDQ 2004)


Extrarenal Rhabdoid Tumor of the Prostate

A rare extrarenal rhabdoid tumor affecting the prostate gland.


Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

A malignant small round cell tumor with or without neural differentiation that is resistant to treatment.


Neuroblastoma recurrent

The reemergence of neuroblastoma after a period of remission.


Unresectable Neuroblastoma

Neuroblastoma which is not amenable to surgical resection.


Stage 2A Neuroblastoma

Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph nodes negative for tumor microscopically. (cancer.gov)


Sinonasal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the nasal cavity and paranasal sinuses.


Medulloblastoma, Molecularly Defined

A term that refers to the classification of medulloblastomas according to their molecular characteristics.


Metastatic Neuroblastoma

A neuroblastoma that has metastasized from its original site of growth to another anatomic site.


Recurrent Childhood Medulloblastoma

The reemergence of childhood medulloblastoma after a period of remission.


Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified

A supratentorial embryonal tumor, not otherwise specified that occurs in childhood.


Extra-osseous Ewing's sarcoma non-metastatic

Ewing sarcoma that arises from the soft tissue and is confined to a specific site without evidence of spread to other anatomic sites.


Medulloblastoma, Not Otherwise Specified

A medulloblastoma which has not been further characterized.


Benign medulloepithelioma of ciliary body

A rare, unilateral, benign embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium.


Extrarenal Rhabdoid Tumor of the Liver

A rare, aggressive primary malignant tumor of the liver that occurs in childhood.  It is characterized by the presence of a diffuse infiltrate of undifferentiated cells with rhabdoid features.


Recurrent tumors of the Ewing's family

The reemergence of a malignant small round cell tumor with or without neural differentiation after a period of remission.


Malignant medulloepithelioma of ciliary body

A rare, unilateral, malignant embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium.


Recurrent Primitive Neuroectodermal Tumor

The reemergence of a primitive neuroectodermal tumor of the central or the peripheral nervous system after a period of remission.


Anaplastic Kidney Wilms Tumor

Wilms tumor of the kidney characterized by the presence of nuclear anaplasia.  Anaplasia is defined by the presence of all of the following: multipolar polyploid mitotic figures, marked nuclear enlargement, and hyperchromasia.  When anaplasia is diffuse, it is associated with an unfavorable clinical outcome.


Disseminated neuroblastoma

Any primary tumor with dissemination to distant lymph nodes, bone, bone marrow, liver, skin, and/or other organs, except as defined for stage 4S. (cancer.gov)


Stage II Kidney Wilms Tumor

Wilms tumor that is found in the kidney and in the fat, soft tissue, or blood vessels near the kidney. It may have spread to the renal sinus. The renal sinus is the part of the kidney where blood and fluid enter and exit the organ. The tumor can be completely removed with surgery. (National Wilms Tumor Study Group Staging System)


Postsurgical Stage IV Hepatoblastoma

Distant metastases, regardless of the extent of liver involvement. (from PDQ 2004)


Localized Askin Tumor

A small round cell tumor confined to a specific area of the thoracic cavity without evidence of spread to other anatomic sites.


Recurrent Kidney Wilms Tumor

The reemergence of Wilms tumor of the kidney after a period of remission.


Small Cell Undifferentiated Hepatoblastoma

A hepatoblastoma composed exclusively of noncohesive sheets of small undifferentiated cells.


Poorly Differentiated Chordoma

A rare, aggressive type of chordoma characterized by loss of SMARCB1 expression. It affects children and occasionally young adults. Females are affected twice as frequently as males. It usually arises in the axial skeleton. It is composed of sheets or nests of malignant epithelioid cells with abundant eosinophilic cytoplasm. The prognosis is poor.


Stage III Kidney Wilms Tumor

Wilms tumor that is found in areas near the kidney and cannot be completely removed with surgery. The tumor may have spread to nearby organs and blood vessels or throughout the abdomen and to nearby lymph nodes. Lymph nodes are tiny, bean-shaped organs that help fight infection. Stage III cancer has not spread outside the abdomen. (National Wilms Tumor Study Group Staging System)


Central Nervous System Embryonal Tumor with Rhabdoid Features

A central nervous system embryonal neoplasm characterized by the presence of histological features consistent with atypical teratoid/rhabdoid tumor and absence of mutations of the INI1 gene or SMARCA4 (BRG1) gene.


Central Nervous System Embryonal Tumor, Not Elsewhere Classified

A central nervous system embryonal tumor lacking molecular abnormalities that would classify it as one of the molecularly defined central nervous system embryonal neoplasms.


Kadish Stage B Olfactory Neuroblastoma

An olfactory neuroblastoma that involves the nasal cavity and paranasal sinuses.


Refractory Wilms Tumor

Wilms tumor that is resistant to treatment.


Localized Unresectable Neuroblastoma

Neuroblastoma that is confined to a specific site and is not amenable to surgical removal.


Childhood Ganglioneuroblastoma, Nodular

A nodular ganglioneuroblastoma that occurs during childhood.


Fourth Ventricle Medulloblastoma

A medulloblastoma occurring in the fourth ventricle.


Kidney Ewing Sarcoma

A rare Ewing sarcoma arising from the kidney.


Kadish Stage A Olfactory Neuroblastoma

An olfactory neuroblastoma that is confined to the nasal cavity


Benign Notochordal Cell Tumor

An intraosseous benign tumor of notochord origin that arises in the bones of the base of the skull, vertebral bodies, sacrum or coccyx.  It contains vacuolated tumor cells without atypia, but lacks myxoid matrix, necrosis, and lobular architecture, which are features that characterize its malignant counterpart, chordoma.  Most lesions are incidental findings.


Central Nervous System Neuroblastoma, FOXR2-Activated

A rare central nervous system embryonal neoplasm with neuroblastic and/or neuronal differentiation. It is characterized by the presence of structural rearrangements of FOXR2 gene that result in the activation of the transcription factor FOXR2.


Hepatoblastoma resectable

Hepatoblastoma amenable to surgical removal.


Refractory Primitive Neuroectodermal Tumor

Primitive neuroectodermal tumor that does not respond to treatment.


Metastatic Medulloblastoma

Medulloblastoma that has spread from its original site of growth to another anatomic site.


medulloblastoma non-WNT/non-SHH group 3

Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog (SHH) pathway. MYC amplifications may be present. TP53 mutations are absent. Patients in this group are usually young children. The overall survival is the worst among all the molecular groups.


Stage 1 Neuroblastoma

Localized tumor with complete gross excision, with or without microscopic residual disease; representative ipsilateral lymph nodes negative for tumor microscopically. (cancer.gov)


Refractory Hepatoblastoma

Hepatoblastoma that does not respond to treatment.


Vulvar Ewing Sarcoma

Ewing sarcoma arising from the vulva.


Central Nervous System Ewing Sarcoma

Ewing sarcoma that arises in the central nervous system.


Region 17p13 Allelic Loss Associated Medulloblastoma

A medulloblastoma characterized by the loss of one of the p13 regions of chromosome 17.  Loss of genetic material of chromosome arm 17p is the most common molecular genetic abnormality found in medulloblastomas.


Recurrent Bone Ewing Sarcoma

The reemergence of Ewing sarcoma of the bone after a period of remission.


Extra-osseous Ewing's sarcoma metastatic

An Ewing sarcoma of the soft tissues which has spread from its original site of growth to another anatomic site.


PRETEXT Stage 4 Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves all 4 quadrants; there is no quadrant free of tumor. (from PDQ 2004)


Sinonasal Olfactory Neuroblastoma

An olfactory neuroblastoma that arises from the sinonasal tract.


Childhood Pineoblastoma

A pineoblastoma that occurs during childhood.


Metastatic Chordoma

A chordoma that has spread from its original site of growth to other anatomic sites.


PRETEXT Stage 2 Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 2 adjoining quadrants; 2 adjoining quadrants are free of tumor. (from PDQ 2004)


Stage I Kidney Wilms Tumor

Wilms tumor that is found in one kidney and can be completely removed with surgery. (National Wilms Tumor Study Group Staging System)


Dedifferentiated chordoma

A high-grade malignant bone tumor arising from the remnants of the notochord. It is characterized by a lobulated growth pattern, myxoid stroma formation, the presence of physaliphorous cells, and a sarcomatous component.


Recurrent Ganglioneuroblastoma

The reemergence of ganglioneuroblastoma after a period of remission.


The reemergence of SHH-activated medulloblastoma after a period of remission.


Childhood Central Nervous System Embryonal Neoplasm

A central nervous system embryonal tumor that occurs during childhood.


Peripheral Primitive Neuroectodermal Tumor of the Kidney

A small round cell tumor with neural differentiation arising from the kidney.


Recurrent Olfactory Neuroblastoma

The reemergence of olfactory neuroblastoma after a period of remission.


Childhood Ganglioneuroblastoma

A ganglioneuroblastoma that occurs during childhood.


Large cell Ewing sarcoma of bone

Ewing sarcoma characterized by the presence of large malignant cells with prominent nucleoli and irregular contours.


Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified

The reemergence of supratentorial embryonal tumor, not otherwise specified in childhood after a period of remission.


PNET of bone localised

A small round cell tumor with neural differentiation that is confined to a specific area of the bone and has not spread to other anatomic sites.


Embryonal Tumor with Multilayered Rosettes without C19MC Alteration

An embryonal tumor with multilayered rosettes characterized by the absence of C19MC amplification. Approximately half of embryonal tumors with multilayered rosettes that lack a C19MC alteration carry DICER1 mutations.


Kadish Stage C Olfactory Neuroblastoma

An olfactory neuroblastoma that extends beyond the nasal cavity and paranasal sinuses.


Nevoid Basal Cell Carcinoma Syndrome Associated Medulloblastoma

A medulloblastoma developing in patients with multiple basal cell carcinomas.  It is observed in patients with nevoid basal cell carcinoma syndrome and it is associated with PTCH gene inactivation.


Medulloblastoma, WNT-activated that is resistant to treatment.


Refractory Medulloblastoma

Medulloblastoma that does not respond to treatment.


Stage 2B Neuroblastoma

Localized tumor with or without complete gross excision, with ipsilateral nonadherent lymph nodes positive for tumor. Enlarged contralateral lymph nodes must be negative microscopically. (cancer.gov)


Childhood Central Nervous System Neuroblastoma

A neuroblastoma that arises from the cerebral hemispheres and occurs during childhood.


SHH-activated medulloblastoma that does not respond to treatment.


Metastatic Bone Ewing Sarcoma

An Ewing sarcoma of the bone which has spread from its original site of growth to another anatomic site.


Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

A small round cell tumor with or without neural differentiation that has spread from its original site of growth to another anatomic site.


medulloblastoma non-WNT/non-SHH group 4

Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog (SHH) pathway. MYC amplifications are absent. TP53 mutations are absent. Chromosome 17 abnormalities may be present.


Metastatic Ewing's Sarcoma

Ewing sarcoma that has spread from its original site of growth to another anatomic site.


Refractory Ewing Sarcoma

Ewing sarcoma that does not respond to treatment.


Recurrent Peripheral Primitive Neuroectodermal Tumor

The reemergence of a small round cell tumor with neural differentiation after a period of remission.


ELP1-Associated Medulloblastoma

An SHH-activated, TP53-wildtype medulloblastoma caused by germline ELP1 gene variations and develops during childhood.


PRETEXT Stage 3 Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 3 adjoining quadrants or 2 nonadjoining quadrants; 1 quadrant or 2 nonadjoining quadrants are free of tumor. (from PDQ 2004)


Teratoid Hepatoblastoma

A hepatoblastoma characterized by the presence of mixed epithelial and mesenchymal components and additional tissues such as striated muscle, bone, epithelial tissues, and melanin pigment.


Mesoblastic nephroma, mixed

A congenital mesoblastic nephroma characterized by the presence of classic and cellular areas.


Refractory Chordoma

A chordoma that does not respond to treatment.


Central Nervous System Ganglioneuroblastoma

A supratentorial primitive neuroectodermal tumor characterized by the presence of poorly differentiated or undifferentiated neuroepithelial cells and ganglion cells.


Childhood Neuroblastoma

A neuroblastoma that occurs during childhood.


Ewing's sarcoma recurrent

Ewing sarcoma which has recurred after treatment and/or remission. While initial complete responses are not uncommon, there is a fair chance of relapse as late as one to two decades after initial therapy.


Calculus of gallbladder with cholecystitis

An acute or chronic inflammation of the gallbladder associated with the presence of gallstones.


Chronic acalculous cholecystitis

Chronic cholecystitis not associated with the presence of gallstones.


Grade 4 Cervix Infection with Unknown Absolute Neutrophil Count, CTCAE


Intracranial Mesenchymal Tumor, FET-CREB Fusion-Positive

A provisional entity that refers to a group of neoplasms with a broad morphological spectrum, characterized by fusion of a FET family gene (usually EWSR1 and rarely FUS) with a member of the CREB family of transcription factors (CREB1, ATF1, or CREM). It includes entities previously termed intracranial angiomatoid fibrous histiocytoma or intracranial myxoid mesenchymal tumor. It is usually located in the supratentorial brain and mostly affects children and young adults. There is a spectrum of clinical behaviors ranging from slowly growing tumors to rapid recurrences, and rarely metastases.


capsaicinoid

A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.


Grade 3 Pain, CTCAE

Severe pain; limiting self care ADL


Diffuse Low Grade Glioma, FGFR1-Mutant

Diffuse low-grade glioma characterized by FGFR1 gene mutations, an internal tandem duplication within the FGFR1 gene or the presence of an FGFR1 fusion gene.


Grade 1 Ventricular Arrhythmia NOS, CTCAE


Grade 4 Premature Delivery, CTCAE

Delivery of a liveborn infant at 24 weeks of gestation or less


Stage IV Rectosigmoid Cancer AJCC v7

Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Astler-Coller B1 Rectal Carcinoma

Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.)


Postprocedural respiratory disorders

A respiratory disorder occurring as a consequence of a procedure.


Grade 2 Salivary Duct Intra-Operative Injury, CTCAE


Salivary Duct Intra-Operative Injury, CTCAE


Grade 4 Salivary Duct Intra-Operative Injury, CTCAE


Grade 3 Salivary Duct Intra-Operative Injury, CTCAE


Grade 1 Salivary Duct Intra-Operative Injury, CTCAE


Vulvar Neoplasm of Skin Appendage Origin

A benign or malignant vulvar neoplasm with differentiating characteristics towards sweat or sebaceous glands or hair follicles.  Representative examples include trichoepithelioma, syringoma, and eccrine adenocarcinoma.


Malignant Vulvar Sweat Gland Neoplasm

A malignant neoplasm that arises from sweat glands in the vulva. Representative examples include eccrine adenocarcinoma, apocrine adenocarcinoma, and Paget disease.


Vulvar Hidradenoma Papilliferum

A benign glandular neoplasm that arises from the vulva. It presents as a mass or cystic lesion in or adjacent to the interlabial sulcus. It is characterized by the presence of complex branching papillae with fibrovascular stalks, lined by uniform columnar epithelial secretory cells and myoepithelial cells.


Vulvar Adenocarcinoma of Sweat Gland Origin

A rare adenocarcinoma arising from vulvar skin sweat glands.


Cirrhosis of the Liver Secondary to Hepatitis C

Cirrhosis of the liver that develops as a sequelae of a hepatitis c infection.


Stage IIA2 Cervical Cancer FIGO 2018

Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, equal or more than 4 cm in greatest dimension. (FIGO 2018)


Grade 3 Lymphatic Infection with Unknown Absolute Neutrophil Count, CTCAE


Triazine

Compounds based on a triazine skeleton.


Any compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure.


Any compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure.


Any member of the class of 1,3,5-triazines that consists of a 1,3,5-triazine skeleton substituted by two amino groups.


Quinazoline

A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.


Grade 4 Urinary Tract Obstruction, CTCAE

Life-threatening consequences; urgent intervention indicated


Anaplastic Hemispheric Astrocytoma

An anaplastic astrocytoma that arises from the cerebral hemispheres.


Frontal Lobe Anaplastic Astrocytoma

An anaplastic astrocytoma occurring in the frontal lobe.


Infant-Type Hemispheric Glioma, MET-Altered

A high-grade cellular astrocytoma that arises in the cerebral hemisphere and occurs in early childhood. It is characterized by receptor tyrosine kinase fusions in the MET gene.


Childhood Cerebral Anaplastic Astrocytoma

A cerebral anaplastic astrocytoma that occurs during childhood.


Parietal Lobe Anaplastic Astrocytoma

An anaplastic astrocytoma occurring in the parietal lobe.


Infant-Type Hemispheric Glioma, ALK-Altered

A high-grade cellular astrocytoma that arises in the cerebral hemisphere and occurs in early childhood. It is characterized by receptor tyrosine kinase fusions in the ALK gene.


Temporal Lobe Anaplastic Astrocytoma

An anaplastic astrocytoma occurring in the temporal lobe.


Cerebral Hodgkin Lymphoma

A Hodgkin lymphoma that arises from the cerebral hemispheres as a primary lesion.


Cerebral Lymphoma in Immunocompetent Host

A cerebral lymphoma that arises in an immunocompetent host.


Infant-Type Hemispheric Glioma, NTRK-Altered

A high-grade cellular astrocytoma that arises in the cerebral hemisphere and occurs in early childhood. It is characterized by receptor tyrosine kinase fusions in the NTRK family.


Grade 4 Eye Infection, CTCAE

Life-threatening consequences; urgent intervention indicated; enucleation


Grade 3 Salivary Gland or Saliva Changes, CTCAE


Epithelioid Hemangioendothelioma with WWTR1-CAMTA1 Gene Fusion

Epithelioid hemangioendothelioma characterized by a t(1;3)(p36;q23-q25) translocation, resulting in a WWTR1-CAMTA1 gene fusion. This translocation and associated gene fusion occur in more than 90% of epithelioid hemangioendotheliomas.


Grade 3 Hyperglycemia, CTCAE

Insulin therapy initiated; hospitalization indicated


Liver Pain, CTCAE

An adverse event characterized by pain originating in the liver.


Laryngeal Inflammatory Myofibroblastic Tumor

An inflammatory myofibroblastic tumor that arises from the larynx.


Grade 2 Cushingoid, CTCAE

Moderate symptoms; medical intervention indicated


Grade 2 Tendon Reflex Decreased, CTCAE

Ankle reflex absent; other reflexes reduced


Grade 4 Lower Extremity Vein Intra-Operative Injury, CTCAE


Orbital emphysema

The presence of air or gas in the subcutaneous tissue of the orbit of the eye.


Grade 4 Urostomy Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 1 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Corrected Prolonged QT Interval by ECG Finding

An electrocardiographic finding in which the QTc interval corrected for heart rate is prolonged. Thresholds for different age, gender, and patient populations exist. (CDISC)