Grade 3 Cranial Nerve VIII Intra-Operative Injury, CTCAE


Monoblastic Sarcoma

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A less common form of myeloid sarcoma composed of monoblasts.  Monoblastic sarcoma may precede or occur simultaneously with acute monoblastic leukemia. (WHO 2001)


Grade 5 Prolapse of Urostomy, CTCAE

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Death


Paraganglioma-Like Dermal Melanocytic Tumor

A benign primary melanocytic tumor of the skin that presents as a dermal nodule. Morphologically, it is characterized by the presence of paraganglioma-like features that include a nested growth pattern of the tumor cells. The nests are composed of epithelioid cells and are separated by delicate fibrous strands. Cytoplasmic melanin is not present; however immunohistochemical studies have confirmed the melanocytic lineage of the tumor cells.


Recurrent Low Grade Astrocytoma

The reemergence of a low grade astrocytoma after a period of remission.


Stage IV Anal Cancer AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Grade 4 Infusion Related Reaction, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Peripheral Arterial Ischemia, CTCAE


Grade 2 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Pancreatitis, CTCAE 5.0

A disorder characterized by inflammation of the pancreas with no documented pancreas infection.


Grade 4 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Delirium due to a general medical condition

A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of a general medical condition.


Soft Tissue Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Cervical Squamous Cell Carcinoma In Situ

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Granular Cell Glioblastoma

A glioblastoma characterized by the presence of large numbers of neoplastic cells with granular, PAS-positive cytoplasm. It is associated with an aggressive clinical course.


Grade 4 Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE


Umbilical granuloma

Excessive granulation tissue at the base of the umbilicus after separation.


Grade 4 Vaginal Inflammation, CTCAE

Life-threatening consequences; widespread areas of mucosal ulceration; urgent intervention indicated


Grade 3 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Erythema Multiforme, CTCAE

Target lesions covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated


Grade 2 Carotid Artery Intra-Operative Injury, CTCAE


Grade 2 Hyperhidrosis, CTCAE

Involving >1 site; patient seeks medical intervention; associated with psychosocial impact


Grade 3 Salivary Gland Intra-Operative Injury, CTCAE


Grade 1 Vaginitis Not Due to Infection, CTCAE


Grade 1 Lymphocele, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Blurred Vision, CTCAE

Intervention not indicated


Grade 2 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Delirium, CTCAE

Death


Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Bladder Stricture or Stenosis, CTCAE


Small Lymphocytic Lymphoma Variant

A term referring to cases of small lymphocytic lymphomas with an increased number of paraimmunoblasts or with signet-ring-like lymphocytes.


Grade 2 Lactation Disorder, CTCAE

Changes in lactation, significantly affecting breast production or expression of breast milk


Grade 1 Hyponatremia, CTCAE

<LLN-130 mmol/L


Grade 4 Intraoperative Reproductive Tract Injury, CTCAE


Grade 3 Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


Grade 3 Eosinophilia, CTCAE

Steroids initiated


Grade 5 Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Hodgkin's disease lymphocyte predominance type refractory

An antiquated term that refers either to nodular lymphocyte predominant Hodgkin lymphoma or to lymphocyte-rich classical Hodgkin lymphoma that is resistant to treatment.


Grade 2 Voice Alteration, CTCAE

Moderate or persistent change from normal voice; still understandable


Local Complication of Device and Prosthesis, CTCAE


Acinar Cystic Transformation of the Pancreas

A non-neoplastic cystic lesion of the pancreas lined by benign-appearing acinar and ductal epithelium. (WHO 2019)


Cocaine dependence, episodic

Physical and psychological dependence on the drug cocaine, which is associated with a pattern of episodic use.


Nerve palsy

Paralysis that is caused by damage to a nerve.


Flatulence, CTCAE

A disorder characterized by a discharge of excessive gas from the lower GI tract.


Stage IIIC Cutaneous Melanoma AJCC v7

Stage IIIC includes: (T1-4b, N1b, M0); (T1-4b, N2b, M0); (T1-4b, N2c, M0); (Any T, N3, M0).  T1-4b: Ulcerated cutaneous melanoma of any thickness.  N1b: Cutaneous melanoma with macrometastasis in one regional lymph node.  N2b: Cutaneous melanoma with macrometastases in 2-3 regional lymph nodes.  N2c: Cutaneous melanoma with intralymphatic metastases (in transit or satellite metastases) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Disseminated Malignant Neoplasm

Cancer that is spread throughout the body, a metastatic phenomenon.


Non-Neoplastic Esophageal Disorder

A non-neoplastic disorder that affects the esophagus. Representative examples include infections, ulcers, and gastroesophageal reflux disease.


Grade 1 Metabolic or Respiratory Alkalosis, CTCAE


Endophthalmitis, CTCAE

A disorder characterized by an infectious process involving the internal structures of the eye.


Grade 2 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage I Fallopian Tube Cancer

Stage I includes: (T1, N0, M0); IA (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to the fallopian tube(s).  T1a: Tumor limited to one tube, without penetrating the serosal surface; no ascites.  T1b: Tumor limited to both tubes, without penetrating the serosal surface; no ascites.  T1c: Tumor limited to one or both tubes with extension onto or through the tubal serosa, or with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Infiltrating Ureter Urothelial Carcinoma with Squamous Differentiation

An infiltrating urothelial carcinoma of the ureter that exhibits squamous differentiation.


Stage II Appendix Neuroendocrine Tumor AJCC v8

Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor measuring more than 2 cm but less than or equal to 4 cm. T3: Tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Belching, CTCAE

Intervention initiated (including over the counter medications)


Large cell calcifying Sertoli cell tumor

A testicular Sertoli cell tumor characterized by the presence of large polygonal cells with eosinophilic cytoplasm in a myxoid and hyalinized stroma. Calcifications may be present in the stroma. Malignant behavior is uncommon.


Grade 5 Edema of the Trunk and Genital Area, CTCAE


Grade 3 Pharyngeal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Congenital Bleeding Disorder

A bleeding disorder that is diagnosed during childhood, with the presenting symptom of excessive bleeding.


Grade 1 Urinary Conduit Intra-Operative Injury, CTCAE


Bladder Anastomotic Leak, CTCAE

A finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures).


Grade 5 Stenosis of Gastrointestinal Stoma, CTCAE

Death


Grade 4 Fallopian Tube Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Other and Unspecified Infectious and Parasitic Diseases and their Sequelae

Unspecified infectious and parasitic diseases and their sequelae other than those otherwise specified.


Grade 2 Eye Infection, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Current Cytomegalovirus Infection

Cytomegalovirus infection is evident at the time of testing.


Grade 2 Lymph Gland Infection, CTCAE

Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage IV Cervical Cancer AJCC v9

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. M1: Distant metastasis including inguinal lymph nodes, lung, liver, bone, or intraperitoneal metastases. Metastases to pelvic or paraaortic lymph nodes, or vagina are excluded. (from AJCC 9th Ed.)


Aortic Injury, CTCAE

A finding of damage to the aorta.


Grade 3 Vaccination Complication, CTCAE

Severe pain; Erythema > 10 cm; Induration/swelling > 10 cm; necrosis; limiting self care ADL


Low Grade Liver Dysplastic Nodule

A hepatic dysplastic nodule characterized by the presence of low grade atypical cellular changes.


Advanced Carcinoma Of Unknown Primary

A carcinoma of unknown primary that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Injury To Inferior Vena Cava, CTCAE

Life-threatening consequences; urgent intervention indicated


Left Ventricular Systolic Dysfunction, CTCAE 5.0

A disorder characterized by failure of the left ventricle to produce adequate output.


Retroperitoneal Hemorrhage, CTCAE 5.0

A disorder characterized by bleeding from the retroperitoneal area.


Recurrent Primary Malignant Central Nervous System Neoplasm

The reemergence of a primary malignant central nervous system neoplasm after a period of remission.


Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Postpartum Uterine Inversion

Protrusion of the uterine fundus through the cervix when the placenta fails to detach from the uterus as it exits.


Grade 5 Sudden Death NOS, CTCAE

Death


Grade 3 Hypoglycemia, CTCAE

<40-30 mg/dL; <2.2-1.7 mmol/L


Grade 5 Cardiac Arrest, CTCAE

Death


Grade 3 Hepatic Artery Intra-Operative Injury, CTCAE


Grade 3 Peritoneal Cavity Hemorrhage, CTCAE


Human Papillomavirus-Independent Cervical Adenocarcinoma

Cervical adenocarcinoma not associated with human papillomavirus infection.


Upper Extremity Intra-Operative Injury, CTCAE


Grade 2 Keratitis, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


Cranial Nerve II Intra-Operative Injury, CTCAE


Grade 3 Infant Irritability, AE

An adverse event in a newborn characterized by severe irritability, major changes in feeding behavior, requiring support other than oral feeding; requiring long term medical treatment (e.g. sedatives).


Grade 4 Esophageal Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Blood Corticotrophin Decreased, CTCAE

A finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen.


Grade 2 Cranial Nerve I Intra-Operative Injury, CTCAE


Advanced Neuroendocrine Carcinoma

A neuroendocrine carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Grade 5 Rectum Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 1 Uterine Pain, CTCAE

Mild pain


Grade 3 Fibrosis-Deep Connective Tissue, CTCAE


Grade 4 Urostomy Obstruction, CTCAE

Life-threatening consequences; organ failure; urgent operative intervention indicated


large cell neuroendocrine carcinoma of bladder

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the bladder.  It is characterized by the presence of malignant large cells.


Grade 1 Prostate Stricture or Stenosis, CTCAE


Stage IIIB Cutaneous Melanoma AJCC v7

Stage IIIB includes: (T1-4b, N1a, M0); (T1-4b, N2a, M0); (T1-4a, N1b, M0); (T1-4a, N2b, M0); (T1-4a, N2c, M0).  T1-4b: Ulcerated cutaneous melanoma of any thickness.  T1-4a: Non-ulcerated cutaneous melanoma of any thickness.  N1a: Cutaneous melanoma with micrometastasis in one regional lymph node.  N2a: Cutaneous melanoma with micrometastases in 2-3 regional lymph nodes.  N1b: Cutaneous melanoma with macrometastasis in one regional lymph node.  N2b: Cutaneous melanoma with macrometastases in 2-3 regional lymph nodes.  N2c: Cutaneous melanoma with intralymphatic metastases (in transit or satellite metastases) without metastatic nodes.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 2 Aorta Artery Intra-Operative Injury, CTCAE


Grade 2 Bone Growth Limb Length Discrepancy, CTCAE


BCLC Stage D Hepatocellular Carcinoma

End-stage hepatocellular carcinoma.  Patients will receive symptomatic treatment. (HPB (Oxford) 2005; 7(1):35-41)


Cervical Squamous Neoplasm

A benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the cervix. Representative examples include condyloma acuminatum, cervical intraepithelial neoplasia, and squamous cell carcinoma.


Grade 5 Phlebitis Infective, CTCAE

Death


High Grade Prostatic Intraepithelial Neoplasia, Signet Ring Variant

High grade prostatic intraepithelial neoplasia characterized by the presence of signet ring cells in the affected glands.


Focal acute inflammation

An inflammatory process characterized by the localized collection of polymorphonuclear neutrophils.


Grade 2 Upper Gastrointestinal Hemorrhage NOS, CTCAE


Grade 3 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Spine Kyphosis or Lordosis, CTCAE


Recurrent Childhood Kidney Neoplasm

The reemergence of renal neoplasm in childhood after a period of remission.


Grade 4 Other Constitutional Symptoms, CTCAE


Grade 3 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Hepatic Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the liver region.


Grade 5 Meningitis, CTCAE

Death


Grade 3 Neonatal Constipation, AE

An adverse event in a newborn characterized by reduced number of stools or hard stools; signs of obstruction; apparent discomfort or affecting feeding; major care changes indicated (e.g. long term medical treatment, enema).


FIGO Stage IB Gestational Trophoblastic Tumor


Recurrent Aggressive NK-Cell Leukemia

The reemergence of aggressive NK-cell leukemia after a period of remission.


Grade 4 Psychiatric Disorders - Other, Specify, CTCAE

Life-threatening consequences; hospitalization or urgent intervention indicated


Grade 4 Lymphatic Infection with Unknown Absolute Neutrophil Count, CTCAE


Benign neoplasm of pineal gland

A non-metastasizing neoplasm that arises from the pineal region.


Grade 1 Restrictive Cardiomyopathy, CTCAE

Imaging findings only


Grade 3 Flushing, CTCAE

Symptomatic, associated with hypotension and/or tachycardia; limiting self care ADL


Supraventricular and Nodal Arrhythmia, CTCAE


Grade 2 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Verrucous carcinoma of the oral cavity stage 0


Grade 4 Neonatal Gastrointestinal Bleeding, AE

A gastrointestinal bleeding adverse event in a newborn characterized by life-threatening consequences (e.g. hemorrhagic shock); urgent major care change required.


Grade 5 Eye Infection, CTCAE

Death


Myeloid Neoplasms with Germline DDX41 Mutation

An autosomal dominant familial myelodysplastic syndrome/acute myeloid leukemia syndrome characterized by inherited mutations in the gene on chromosome 5 encoding the DEAD box RNA helicase DDX41. Patients usually present with leukopenia, hypocellular bone marrow with prominent erythroid dysplasia and a normal karyotype, often leading to erythroleukemia. The prognosis is generally poor. (WHO 2017)


Unresectable Glioma

A glioma that is not amenable to surgical resection.


Grade 1 Lip Or Perioral Area Intra-Operative Injury, CTCAE


Visual Pathway Neoplasm

A neoplasm that affects the visual pathway.


Grade 5 Nose Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Polyclonal Polymorphic Post-Transplant Lymphoproliferative Disorder


Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


Blood Antidiuretic Hormone Abnormal, CTCAE

A finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen.


Recurrent Primary Bone Lymphoma

The reemergence of primary lymphoma of bone after a period of remission.


Metastatic Appendix Carcinoma

Carcinoma of the appendix that has spread from the original site of growth to other anatomic sites.


Grade 3 Abdomen Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Lethargy, CTCAE

A disorder characterized by a decrease in consciousness characterized by mental and physical inertness.


AIDS-Related Anal Carcinoma

A carcinoma arising from the anus and occurring in HIV-positive patients. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Sexually transmitted human papillomavirus is detected in the majority of the cases.


Schwannoma of the Seventh Cranial Nerve

A benign, usually encapsulated slow growing tumor composed of Schwann cells affecting the seventh cranial nerve.


Grade 3 Urethral Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 5 Peristomal Infection with Unknown Absolute Neutrophil Count, CTCAE


Locally Advanced Bladder Carcinoma

A bladder carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Congenital Hand and Foot Deformity

A malformation in the hand or foot that is present at birth. Representative examples include syndactyly, polydactyly, brachydactyly, and thumb hypoplasia.


Grade 3 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Neonatal Edema, AE

An adverse event in a newborn characterized by severe edema; limiting age appropriate behavior; requiring major care changes (e.g. diuretics).


Grade 1 Anemia, CTCAE

Hemoglobin (Hgb) <LLN-10.0 g/dL; <LLN-6.2 mmol/L; <LLN-100 g/L


Chronic esophagitis

A chronic inflammatory process affecting the esophageal wall.


Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Vaginal Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Low Grade Lung Neuroendocrine Neoplasm

A low grade malignant neoplasm with neuroendocrine differentiation that arises from the lung.  This category includes typical carcinoid tumor.


Chest Pain in Left Second Intercostal Space

The location of the chest pain is within the second intercostal space on the left side.


Grade 1 Gastrointestinal Pain, CTCAE

Mild pain


Grade 4 Brain Intra-Operative Injury, CTCAE


Adult Diffuse Small Cleaved Cell Lymphoma

An antiquated term for a diffuse B-or T-cell lymphoma composed of small cleaved lymphocytes, occurring in adults.


Grade 1 Ankle Fracture, CTCAE

Mild; non-operative intervention indicated


Grade 5 Burn, CTCAE

Death


Grade 5 Other Hepatobiliary and Pancreas, CTCAE


Recurrent T-Cell Large Granular Lymphocyte Leukemia

The reemergence of T-cell large granular lymphocyte leukemia after a period of remission.


Mixed acidophil-basophil carcinoma

A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic and basic dyes.


Grade 5 Cranial Nerve VIII Neuropathy, CTCAE


Postneoadjuvant Therapy Stage II Esophageal Adenocarcinoma AJCC v8

Stage II includes: T3, N0, M0. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Oral Dysesthesia, CTCAE

A disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth.


Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted

An oligodendroglioma carrying IDH gene family mutation and combined whole-arm losses of 1p and 19q (1p/19q codeletion).


Grade 3 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Tissue Breakdown

A process caused by injury or disease or aging and characterized by a partial/complete disruption of tissue. The disruption may be temporary or permanent and may be associated with either (1) impairment or (2) loss of function of the affected organ(s) or system(s).


Locally Advanced Squamous Cell Carcinoma of Unknown Primary

A squamous cell carcinoma of unknown primary that has spread from its original site of growth to nearby tissues or lymph nodes.


Hypoxic Ischemic Encephalopathy, AE

An adverse event in a newborn characterized by injury to the central nervous system that occurs when there is insufficient delivery of oxygen to all or part of the brain.


Adverse Event Associated with Surgery and Intra-Operative Injury


Outer Hair Sheath and Infundibulum Neoplasm

A neoplasm involving the outer hair sheath and infundibulum.


Grade 3 Soft Tissue NOS Intra-Operative Injury, CTCAE


Laryngeal Stenosis, CTCAE

A disorder characterized by a narrowing of the laryngeal airway.


Magnocellular nevus

A benign neoplastic melanocytic proliferation within or adjacent to the optic disk. It presents as a pigmented, intraocular tumor.


Grade 3 Local Complication of Device and Prosthesis, CTCAE


Grade 3 Bladder Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Stage IVB Bone Sarcoma AJCC v7

Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Central Nervous System Hemangioblastoma

A hemangioblastoma arising from structures of the central nervous system.


Body Substance Discharge

The leakage of a substance from an orifice or wound.


Juxtaglomerular tumor

A benign, well circumscribed neoplasm arising from the cortex of the kidney. It secrets renin and the patients usually present with severe hypertension and marked hypokalemia. Morphologically, it is characterized by the presence of sheets of polygonal or spindle-shaped neoplastic cells forming a hemangiopericytic pattern.


Grade 2 Spermatic Cord Stricture or Stenosis, CTCAE


Grade 4 Peripheral Sensory Neuropathy, CTCAE

Life-threatening consequences; urgent intervention indicated


Clinical Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IIB includes: T2, N0, M0. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Anal Stenosis, CTCAE

Death


Grade 2 Stroke, CTCAE

Mild to moderate neurologic deficit; limiting instrumental ADL


Grade 3 Hypothyroidism, CTCAE

Severe symptoms; limiting self care ADL; hospitalization indicated


Grade 4 Vas Deferens Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Biliary Fistula, CTCAE

Death


Giant Fibrovascular Esophageal Polyp

A benign, elongated intraluminal polypoid neoplasm of the esophagus.  It is characterized by the presence of adipose tissue lobules separated by dense fibrous tissue bands and dilated blood vessels.  The polyp is covered by normal squamous epithelium.


Grade 3 Neonatal Gastrointestinal Bleeding, AE

A gastrointestinal bleeding adverse event in a newborn characterized by severe bleeding; non-life threatening hemodynamic consequences; major care change required (e.g. invasive intervention, transfusion, long term medical treatment).


Persistent Hyaloid Vessels

A congenital abnormality of the eye caused by failure of regression of the fetal eye vasculature.


Spasticity, CTCAE

A disorder characterized by increased involuntary muscle tone that affects the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances.


Gallbladder Adenocarcinoma, Gastric Foveolar Type

An unusual, well differentiated adenocarcinoma that arises from the gallbladder.  It is characterized by the presence of tall malignant columnar cells with mucin-containing cytoplasm and basally located nuclei.


Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Transport Injury

An injury to an individual during transport between or to/from departments or facilities.


Gastric Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the stomach.  It is characterized by the presence of malignant large cells.


large cell neuroendocrine carcinoma of gallbladder

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder.  It is characterized by the presence of malignant large cells.


Localized Malignant Pancreatic Neoplasm

A malignant neoplasm that arises from the pancreas and has not spread to other anatomic sites.


Non-T Non-B CALLA Negative Childhood Acute Lymphoblastic Leukemia

Non-T non-B, CALLA negative acute lymphoblastic leukemia that occurs during childhood.


Grade 3 Anemia, CTCAE

Hgb <8.0 g/dL; <4.9 mmol/L; <80 g/L; transfusion indicated


Superior Vena Cava Intra-Operative Injury, CTCAE


Grade 5 Uterine Perforation, CTCAE

Death


Grade 1 Breast Pain, CTCAE

Mild pain


Metastatic Appendix Mucinous Adenocarcinoma

Mucinous adenocarcinoma of the appendix that has spread from the original site of growth to other anatomic sites.


Grade 3 Lymphedema, CTCAE

Severe symptoms; limiting self care ADL


Pedestrian Injury By Road Vehicle

An injury to a pedestrian sustained by a vehicle that travels on the road.


Stage IB Ampulla of Vater Cancer AJCC v8

Stage IB includes: (T1b, N0, M0); (T2, N0, M0). T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Paroxysmal Atrial Tachycardia, CTCAE

Life-threatening consequences; incompletely controlled medically; cardioversion indicated


Functional disorder of polymorphonuclear neutrophil

A disorder caused by a dysfunction of polymorphonuclear neutrophils (PMNs).


Grade 1 Small Bowel NOS Intra-Operative Injury, CTCAE


Grade 1 Pancreatic Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Lethargy, CTCAE

Moderate symptoms; limiting instrumental ADL


Closed traumatic dislocation of glenohumeral joint

A closed dislocation of the shoulder


Stage 0 Appendix Carcinoma AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ (intramucosal carcinoma; invasion of the lamina propria or extension into but not through the muscularis mucosae). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Gastrointestinal Stoma Necrosis, CTCAE

Life-threatening consequences; urgent intervention indicated


Refractory Ureter Urothelial Carcinoma

Ureter urothelial carcinoma that is resistant to treatment.


Stage IA Cervical Cancer AJCC v9

Stage IA includes: T1a, N0, M0. T1a: Tumor that can be diagnosed only by microscopy with maximum depth of invasion equal or less than 5 mm. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IB Vulvar Cancer AJCC v7

Stage IB includes: T1b, N0, M0.  T1b: Vulvar cancer with tumor size greater than 2 cm, or any size with stromal invasion more than 1.0 mm, confined to the vulva or perineum.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Kappa Light Chain-Restriction

An increase in the ratio of cells expressing the immunoglobulin light chain (Ig LC) kappa versus those expressing Ig LC lambda in a sample.


Neoplastic Post-Transplant Lymphoproliferative Disorder

A lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy.  It is characterized by the presence of tissue destruction and effacement of the architecture of the involved tissues.  There is clonal rearrangement of the immunoglobulin or the T-cell receptor genes.  It includes the following variants: polymorphic, monomorphic, and classical Hodgkin lymphoma type post-transplant lymphoproliferative disorders.


Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage 0 Vaginal Cancer AJCC v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma). N0: No regional lymph node metastasis.  M0: No distant metastasis.  FIGO no longer includes stage 0. (AJCC 7th ed.)


Round cell sarcoma with EWSR1-non-ETS fusions

A group of rare round and spindle cell sarcomas characterized by the presence of EWSR1 or FUS fusions involving partners unrelated to the ETS gene family. This category includes EWSR1-NFATC2, EWSR1-PATZ1, and FUS-NFATC2 sarcomas.


Grade 1 Meningismus, CTCAE

Mild symptoms


Stage IIA2 Cervical Cancer AJCC v9

Stage IIA2 includes: T2a2, N0, M0. T2a2: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 2 Atrioventricular Block First Degree, CTCAE

Non-urgent intervention indicated


Grade 4 Urinary Retention, CTCAE

Life-threatening consequences; organ failure; urgent operative intervention indicated


Grade 1 Hydrocephalus, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage I Prostate Cancer AJCC v7

Stage I includes: (T1a-c, N0, M0, PSA less than 10, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 10, Gleason equal or less than 6); (T1-2a, N0, M0, PSA X, Gleason X).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less. cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason X: Gleason score cannot be processed.  (AJCC 7th ed.)


Uterine Cervix Cyst

A cyst in the uterine cervix.


Grade 3 Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Mediastinum Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IV Appendix Carcinoma AJCC v8

Stage IV includes: IVA: (Any T, N0, M1a); (Any T, Any N, M1b, G1); IVB: (Any T, Any N, M1b, G2, G3, or GX); IVC: (Any T, Any N, M1c, Any G). N0: No regional lymph node metastasis. M1a: Intraperitoneal acellular mucin, without identifiable tumor cells in the disseminated peritoneal mucinous deposits. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. M1c: Metastasis to sites other than peritoneum. G1: Well differentiated. G2: Moderately differentiated. G3: Poorly differentiated. GX: Grade cannot be assessed. (AJCC 8th ed.)


Grade 1 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 4 Vulva Intra-Operative Injury, CTCAE


Grade 4 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Superior Vena Cava Intra-Operative Injury, CTCAE


Hallucinogen dependence, continuous

Physical and psychological dependence on hallucinogenics, which is associated with a pattern of continuous use.


Grade 2 Sinus Disorder, CTCAE

Symptomatic stenosis or edema/narrowing interfering with airflow; limiting instrumental ADL


Regressing Non-Cutaneous Melanoma

The disappearance of the melanoma cells from the primary non-cutaneous melanoma site.


IgM monoclonal gammopathy of uncertain significance

Monoclonal gammopathy of undetermined significance defined by a serum IgM paraprotein concentration less than 30g/L; bone marrow lymphoplasmacytic infiltration of less than 10%; and no evidence of anemia, constitutional symptoms, hyperviscocity, lymphadenopathy, hepatosplenomegaly, or other end-organ damage that can be attributed to the underlying lymphoproliferative disorder. It is a precursor condition that may progress to lymphoplasmacytic lymphoma/ Waldenstrom macroglobulinemia, other B-cell neoplasms, or primary amyloidosis. Progression to plasma cell myeloma occurs rarely, if at all. (WHO 2017)


Grade 3 Vaginal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Stage IIIB Digestive System Neuroendocrine Tumor AJCC v7

Stage IIIB includes: Any T, N1, M0. N1: Regional lymph node metastasis. M0: No distant metastasis.  (AJCC 7th ed.)


Grade 5 Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Lipase Increased, CTCAE

>ULN-1.5 x ULN


Grade 1 Gastric Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Secondary Central Nervous System Lymphoma

A non-Hodgkin or Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


Grade 5 Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malignant gastrinoma of pancreas

A gastrin-producing neuroendocrine tumor arising from the pancreas.  It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome.  It displays vascular invasion and metastasizes to other anatomic sites.


Benign nipple neoplasm

A non-metastasizing neoplasm that arises in the area of the nipple.


Grade 4 Rectal Varices Hemorrhage, CTCAE


Grade 5 Acute Kidney Injury, CTCAE

Death


Intermediate Chondrogenic Neoplasm

A locally aggressive or rarely metastasizing cartilaginous matrix-producing neoplasm characterized by the presence of neoplastic chondrocytes.


Liver Teratoma

A teratoma that arises from the liver.


Non-Organic Failure to Thrive

Failure to thrive caused by inadequate intake due to environmental influences, stimulus deprivation- poverty, feeding techniques, or psychological reason, and without any apparent growth-inhibiting organic disorder.


Grade 1 Tooth Discoloration, CTCAE

Surface stains


Grade 2 Biliary Tree Stricture or Stenosis, CTCAE


Adverse Event Associated with Allergy and Immunology


Human Papillomavirus-Related Urethral Squamous Cell Carcinoma

A rare urethral squamous cell carcinoma that is related to human papilloma virus (HPV) infection of the urinary tract.


Grade 1 Spinal Cord Intra-Operative Injury, CTCAE


Papillary mucinous cystadenoma, borderline malignancy

A low malignant potential cystic epithelial neoplasm usually arising from the ovary. It is composed of glandular cells with intracytoplasmic mucin. It is characterized by an atypical epithelial proliferation and a papillary growth pattern. There is no evidence of destructive stromal invasion.


Locally Advanced Glioblastoma

Glioblastoma that has spread from its original site of growth to nearby tissues.


Stage IIA Bone Cancer AJCC v7

Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Stage IIA Nasopharyngeal Keratinizing Squamous Cell Carcinoma


Grade 4 Cranial Nerve XII Intra-Operative Injury, CTCAE


Grade 4 Abdomen Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Premature Delivery, CTCAE

Delivery of a liveborn infant at >28 to 34 weeks gestation


familial meningioma

A meningioma that is transmitted from the parents to an offspring.


Grade 1 Vascular Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Stage III Low-CSD Melanoma AJCC v7

Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 5 Other Growth and Development, CTCAE


Adult Respiratory Distress Syndrome, CTCAE

A disorder characterized by progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery.


Grade 5 Thrombotic Thrombocytopenic Purpura, CTCAE

Death


Erythema multiforme minor

Self-limiting form of erythema multiforme.


Unresectable Bladder Urothelial Carcinoma

Bladder urothelial carcinoma that is not amenable to surgical resection.


Grade 3 Biliary Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 4 Budd-Chiari Syndrome, CTCAE

Life-threatening consequences; moderate to severe encephalopathy; coma


Locally Advanced Fibrosarcoma

Fibrosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Small Intestinal Mucositis, CTCAE

Severe pain; interfering with oral intake; tube feeding, TPN or hospitalization indicated; limiting self care ADL


Edema of foot (finding)

The accumulation of fluid in the feet, most prominently on the dorsum.


Epithelial hyperplasia of skin

A hyperplasia of the epidermis.


Guillain-Barre Syndrome, CTCAE

A disorder characterized by the body's immune system attacking the peripheral nervous system causing ascending paralysis.


Morbidly adherent placenta (disorder)

A condition in which the placenta implants abnormally into the uterine myometrium, rather than implanting into the uterine decidua basalis as is normal.


Stage IVB Bone Cancer AJCC v8

Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G). N1: Regional lymph node metastasis. M1b: Metastasis in the bone or other distant sites. (AJCC 8th ed.)


A psychological or behavioral condition that existed previously and is genetic in nature.


Hypoglossal Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the hypoglossal nerve (twelfth cranial nerve).


Respiratory, thoracic and mediastinal disorders

A non-neoplastic or neoplastic disorder that affects the respiratory system or the thoracic organs.


clear cell type neoplasm

A malignant neoplasm characterized by the presence of atypical cells with clear cytoplasm.


Grade 4 External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Dysmenorrhea, CTCAE

A disorder characterized by abnormally painful abdominal cramps during menses.


Grade 5 Uterine Fistula, CTCAE

Death


Stage IIA1 Cervical Cancer AJCC v7

Stage IIA1 includes: T2a1, N0, M0.  Tumor invades beyond uterus but no to pelvic wall or to lower third of vagina. No parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 2 Arterial Injury, CTCAE

Symptomatic; repair or revision not indicated


Grade 3 Uterine Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 3 Neutrophil Count Decreased, CTCAE

<1000-500/mm3; <1.0-0.5 x 10e9/L


Grade 5 Arterial Thromboembolism, CTCAE

Death


Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Increased Uric Acid Level

A laboratory test result indicating abnormally high concentration of uric acid in the blood.


Spindle cell melanoma, type A

A melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli. Representative example is the type A spindle cell uveal melanoma.


Post-traumatic wound infection

Infection of a wound following trauma.


Stage II Esophageal Adenocarcinoma AJCC v7

Stage II includes: IIA (T2, N0, M0, G3); IIB (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis. G3: Poorly differentiated.  (AJCC 7th ed.)


Grade 5 Ileum Infection with Unknown Absolute Neutrophil Count, CTCAE


Esophageal Adenocarcinoma by AJCC v8 Clinical Stage

A term that refers to the clinical staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Anogenital papillomaviral intraepithelial neoplasia


Sinusoidal Obstruction Syndrome, CTCAE

A disorder characterized by severe hepatic injury as a result of the blood vessels of the liver becoming inflamed and/or blocked.


Ovarian Rupture

Tearing or disruption of the ovarian tissue.


Grade 2 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gastric Juvenile Polyp

A non-neoplastic polyp that arises from the stomach and is characterized by the presence of elongated, tortuous, and cystic foveolar zones, edematous changes, and inflammation.  It may be associated with juvenile polyposis in other parts of the gastrointestinal tract.


Bone Langerhans Cell Histiocytosis

Langerhans cell histiocytosis affecting the bone.


Grade 4 Genitourinary Stoma Hemorrhage, CTCAE


Palpitations, CTCAE

A disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart.


Low Grade Conjunctival Squamous Intraepithelial Neoplasia

A precancerous neoplastic intraepithelial process with low-grade dysplastic features involving the conjunctival epithelium.


Rhinitis Infective, CTCAE

A disorder characterized by an infectious process involving the nasal mucosal.


Grade 3 Retina Intra-Operative Injury, CTCAE


Grade 5 Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Bronchial Stricture, CTCAE

Death


Grade 4 Malabsorption, CTCAE

Life-threatening consequences; urgent intervention indicated


Musculoskeletal Chest Pain due to Epidemic Myalgia

A condition in which there is myositis secondary to an infectious etiology. (ACC/AHA)


Recurrent AL Amyloidosis

The reemergence of AL amyloidosis after a period of remission.


Serous cystadenoma, borderline malignancy

A serous cystic glandular epithelial neoplasm of low malignant potential. It is characterized by the presence of atypical or malignant glandular epithelial cells with an absence of stromal invasion.


Grade 3 Vaginal Fistula, CTCAE

Invasive intervention indicated


Unresectable Hepatocellular Carcinoma

A hepatocellular carcinoma that is not amenable to surgical resection.


Ann Arbor Stage II Subdiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


Grade 4 Outer Ear Pinna Intra-Operative Injury, CTCAE


Bruising, CTCAE

A finding of injury of the soft tissues or bone characterized by leakage of blood into surrounding tissues.


Grade 5 Skin Induration, CTCAE

Death


Gastroesophageal Junction Adenocarcinoma by AJCC v8 Stage

A term that refers to the staging of gastroesophageal junction adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Grade 4 Neonatal Hypertension, AE

A hypertensive adverse event in a newborn characterized by life-threatening consequences (e.g. malignant hypertension: shock, cardiac failure or neonatal encephalopathy).


Amyloidoma

Nodular localized form of amyloidosis with predominantly thoracic localization (pulmonary amyloidosis), considered as secondary protein structure disease in which insoluble protein fibrils accumulate extracellularly. The form of primary amyloid in amyloidoma is characterized by abnormal deposition of light chain proteins composed of monoclonal immunoglobulin. Pulmonary amyloidomas are rare and are often found incidentally as solitary or multiple calcified nodules and masses on chest radiographs in asymptomatic elderly patients. Cavitation is rare, the prognosis is good.


Lugano Classification Stage I Adult Hodgkin Lymphoma AJCC v8

Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Grade 4 Intraoperative Head and Neck Injury, CTCAE


Urinary straining

The need to increase intra-abdominal pressure in order to initiate and maintain voiding.


Grade 1 Slipped Capital Femoral Epiphysis, CTCAE


Somatostatinoma, malignant

A neuroendocrine tumor arising from delta cells which produce somatostatin. It displays vascular invasion and metastasizes to other anatomic sites.


Grade 3 Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Neoplasms, Radiation-Induced

A neoplasm that develops as a result of exposure to radiation.


Respiratory Failure, CTCAE

A disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide.


Grade 3 Small Bowel Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


COVID-19-Associated Acute Hemorrhagic Necrotizing Encephalitis

Acute hemorrhagic necrotizing encephalitis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Grade 2 Pulmonary Fibrosis Radiographic Changes, CTCAE


Grade 4 Kidney Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Urostomy Stenosis, CTCAE

Symptomatic (e.g., hydronephrosis, or renal dysfunction); elective operative intervention indicated


Stage IIIA Fallopian Tube Cancer AJCC v8

Stage IIIA includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Micropapillary urothelial carcinoma

A transitional cell carcinoma characterized by a micropapillary growth pattern. Typical example is the micropapillary variant of infiltrating bladder urothelial carcinoma.


Grade 1 Small Bowel Stricture or Stenosis NOS, CTCAE


Serious Adverse Experience

A situation referring to a severe reaction, risk or indication against use of a treatment or device.


Grade 3 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Bone Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Glioneuroma of ciliary body

A congenital choristoma in the ciliary body. It consists of a mass of mature glial and neuronal cells without neoplastic potential in an otherwise healthy child; there is usually an adjacent coloboma of the anterior uvea and retina. (WHO 2018)


Grade 4 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Increased Time To Concomitant Drug Peak Blood Concentration

Increased time following concomitant drug administration at which the peak drug blood concentration occurs.


Grade 2 Vaginal Dryness, CTCAE

Moderate vaginal dryness interfering with sexual function or causing frequent discomfort


Cerebral Adrenoleukodystrophy

A subtype of adrenoleukodystrophy (ALD) occurring in approximately 40 percent of boys with ALD, primarily affecting the cerebrum, resulting in rapidly declining neurocognitive function and in most patients, premature death.


Refractory Ocular Melanoma

Ocular melanoma that is resistant to treatment.


Castration-Naive Prostate Carcinoma

Advanced prostatic carcinoma which was not previously treated with androgen-deprivation therapy.


Grade 4 Cranial Nerve XI Neuropathy, CTCAE


Grade 2 Ophthalmoplegia and Diplopia, CTCAE


Grade 1 Rectal Varices Hemorrhage, CTCAE


Withdrawal (dysfunction)

A social or emotional detachment, pathological retreat from objective reality, interpersonal contact and social involvement, as in some forms of schizophrenia, depression, or schizoid, avoidant, or schizotypal personality disorders.


Grade 5 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

Death


Psychiatric Disorders - Other, Specify, CTCAE


Muscular Dystrophy Secondary to Oxidative Phosphorylation Disorder

A muscular dystrophy that was caused by a primary disorder of oxidative phosphorylation.


Refractory Malignant Skin Neoplasm

Malignant skin neoplasm that is resistant to treatment.


Stage IIA Appendix Carcinoma AJCC v7

Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into subserosa or into mesoappendix.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IV Cutaneous Melanoma AJCC v6 and v7

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


Encephalitis Infection, CTCAE

A disorder characterized by an infectious process involving the brain tissue.


COVID-19-Associated Albuminuria

Albuminuria caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Intraductal papillary neoplasm with low-grade intraepithelial neoplasia

An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of mild epithelial atypia.


Nasal Cavity and Paranasal Sinus Reactions, CTCAE


Stage 0a Urethral Cancer AJCC v8

Stage 0a includes: Ta, N0, M0. Ta: For male penile urethra and female urethra: Non-invasive papillary carcinoma. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Skin Papilloma, CTCAE

Intervention initiated


Grade 3 Prostate Intra-Operative Injury, CTCAE


Grade 3 Jejunal Fistula, CTCAE

Invasive intervention indicated


Defective Gamma Heavy Chain Present

An indication that cells expressing a mutated or defective form of immunoglobulin heavy chain gamma have been detected in a sample.


Grade 2 Local Complication of Device and Prosthesis, CTCAE


Grade 5 Laryngeal Nerve Dysfunction, CTCAE


Stage IIIB Gallbladder Cancer AJCC v7

Stage IIIB includes: T1-3, N1, M0. T1: Tumor invades lamina propria or muscular layer.  T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver. T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. M0: No distant metastasis. (from AJCC 7th Ed.)


Phobia of driving

An overwhelming, irrational, and persistent fear of operating a motor vehicle.


Refractory Bladder Carcinoma

Bladder carcinoma that does not respond to treatment.


Stage IIIC Anal Cancer AJCC v8

Stage IIIC includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor larger than 5 cm. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Meninges Intra-Operative Injury, CTCAE


Grade 4 Cystitis Noninfective, CTCAE

Life-threatening consequences; urgent invasive intervention indicated


Grade 1 Pain of Skin, CTCAE

Mild pain


Appendicitis, CTCAE

A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent.


Grade 1 Gastrointestinal Stoma Intra-Operative Injury, CTCAE


Grade 5 Other Pulmonary and Upper Respiratory, CTCAE


Facial Nerve Palsy Related to Trauma

Partial or complete paralysis of the facial muscles of one side of an individual's face that is caused by trauma.


Chemotherapy-Related Leukemia

A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor.


Grade 5 Urostomy Site Bleeding, CTCAE

Death


Grade 2 Neonatal Rash, AE

An adverse event in a newborn characterized by diffuse rash or target lesions.


Grade 4 Serum Amylase Increased, CTCAE

>5.0 x ULN and with signs or symptoms


Grade 2 Inferior Vena Cava Intra-Operative Injury, CTCAE


Posterior Fossa Ependymoma

A circumscribed ependymoma that arises in the posterior fossa. The diagnosis of posterior fossa ependymoma should be made either when molecular analysis for DNA methylation profiling cannot assign a molecular group (not elsewhere classified -NEC) or when the molecular analysis for DNA methylation profiling was unsuccessful or not reported (not otherwise specified-NOS).


Grade 3 Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


Grade 5 Shingles, CTCAE

Death


Duodenal Perforation, CTCAE

A disorder characterized by a rupture in the duodenal wall.


Grade 2 Ear and Labyrinth Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Recurrent Appendix Adenocarcinoma

The reemergence of appendix adenocarcinoma after a period of remission.


Grade 2 Lumbar Spine Range of Motion, CTCAE


Grade 3 Hyperthyroidism, CTCAE

Severe symptoms; limiting self care ADL; hospitalization indicated


Electrocardiogram QT Corrected Interval Prolonged, CTCAE

A finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval.


Grade 3 Hyperkeratosis, CTCAE

Limiting self-care ADLs


Pericardial Tamponade, CTCAE

A disorder characterized by an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium.


Breast Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the breast region.


Intraoperative Breast Injury, CTCAE

A finding of damage to the breast parenchyma during a surgical procedure.


Poorly Differentiated Malignant Neoplasm

A neoplasm whose histologic characteristics have regressed and are more similar to stem cells.


Grade 5 Pleural Infection, CTCAE

Death


Grade 1 Skin Ulceration, CTCAE

Combined area of ulcers <1 cm; nonblanchable erythema of intact skin with associated warmth or edema


Advanced Digestive System Carcinoma

Digestive system carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Vulvar Squamous Cell Carcinoma, Not Otherwise Specified

Vulvar squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Otitis Middle Ear Non Infectious, CTCAE


Grade 1 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Pharyngeal Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Urinary Frequency or Urgency, CTCAE


Vestibulocochlear nerve palsy

Partial or complete paralysis of the vestibulocochlear nerve.


Grade 5 Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Vulvar Carcinoma

A carcinoma that arises from the vulva and has metastasized to another anatomic site.


Grade 3 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Cranial Nerve V Motor Intra-Operative Injury, CTCAE


Post inflammatory hydrocephalus

An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a consequence of a central nervous system inflammation.


Current HIV Infection

Human immunodeficiency virus infection is evident at the time of testing.


Grade 1 Vaginal Discharge, CTCAE

Mild vaginal discharge (greater than baseline for patient)


Localized Cerebral Neoplasm

A cerebral neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Grade 3 Pancreatic Duct Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Infection of hemodialysis catheter

A local or systemic infection associated with the use of a hemodialysis catheter.


Urothelial carcinoma recurrent

The reemergence of urothelial carcinoma after a period of remission.


Cranial Nerve Infection

An infectious process affecting a cranial nerve.


Grade 5 Glossopharyngeal Nerve Disorder, CTCAE

Death


Stage IB Testicular Cancer AJCC v8

Stage IB includes: (pT2, N0, M0, S0); (pT3, N0, M0, S0); (pT4, N0, M0, S0). pT2: Testicular cancer which is limited to testis (including rete testis invasion) with lymphovascular invasion or invades hilar soft tissue or epididymis or penetrates visceral mesothelial layer covering the external surface of tunica albuginea with or without lymphovascular invasion. pT3: Testicular cancer in which the tumor invades spermatic cord with or without lymphovascular invasion. pT4: Testicular cancer in which the tumor invades scrotum with or without lymphovascular invasion. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


Grade 1 Duodenal Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Tuberculosis of urinary organs

The infection of a urinary organ due to Mycobacterium tuberculosis.


Contact dermatitis due to dichromate

Allergic contact dermatitis caused by exposure to dichromate.


Vaginal Non-Keratinizing Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the vagina and is characterized by the presence of polygonal squamous cells. Intercellular bridges and cytoplasmic keratinization may be present, but keratin pearls are absent.


Grade 5 Gastritis, CTCAE

Death


Recurrent Acute Myeloid Leukemia with Myelodysplasia-Related Changes

The reemergence of acute myeloid leukemia with myelodysplasia-related changes after a period of remission.


Micropapillary carcinoma

A carcinoma characterized by the presence of a predominant micropapillary pattern.


Transfusion Dependent Beta Thalassemia

Beta thalassemia that results in severe anemia and requires regular blood transfusions for patient survival.


Grade 3 Stoma Pulmonary Hemorrhage, CTCAE


Grade 1 Testosterone Deficiency, CTCAE

Asymptomatic; mild symptoms with no intervention indicated


Locally Recurrent Skin Squamous Cell Carcinoma

The reemergence of skin squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Pancreaticobiliary Malunion

An abnormality of the pancreatic and biliary ducts in which their junction occurs above the duodenal wall.


Grade 5 Bladder Anastomotic Leak, CTCAE

Death


Grade 1 Cranial Nerve XII Intra-Operative Injury, CTCAE


Grade 2 Anal Mucositis, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Soft Tissue Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Grade 3 External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Dry Eye, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


Grade 5 Peritoneal Cavity Hemorrhage, CTCAE


Stage IVA Appendix Carcinoma AJCC v7

Stage IVA includes: Any T, N0, M1a, G1.  N0: No regional lymph node metastasis.  M1a: Intraperitoneal metastasis beyond the right lower quadrant, including pseudomyxoma peritonei.  G1: Well differentiated tumor.  (AJCC 7th ed.)


Grade 3 Gallbladder Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 4 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


Kidney Solitary Fibrous Tumor

A rare solitary fibrous tumor arising from the kidney.


Grade 2 Cholesterol High, CTCAE

>300-400 mg/dL; >7.75-10.34 mmol/L


Lugano Classification Adult Lymphoma by AJCC v8 Stage

A staging system for adult Hodgkin and adult non-Hodgkin lymphomas based on the Lugano classification criteria. This staging system does not apply to ocular adnexal lymphomas (are staged according to the classification for ocular adnexal lymphoma), pediatric lymphomas (are staged according to the classification for pediatric lymphoma), primary cutaneous lymphomas (are staged according to the classification for primary cutaneous lymphoma), and multiple myelomas (are staged according to the classification for plasma cell myeloma). (from AJCC 8th Ed.)


Grade 5 Gastric Ulcer, CTCAE

Death


Grade 1 Serum Glutamic Oxaloacetic Transaminase, CTCAE


Hearing Patients without Baseline Audiogram and Not Enrolled in a Monitoring Program, CTCAE


Grade 5 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Adult Central Nervous System Neoplasm

A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in adults.  Representative examples of primary neoplasms include astrocytoma, meningioma, pituitary adenoma, and neurilemoma.  Representative examples of tumor metastases from other organs to the central nervous system include lung and breast carcinoma.


Grade 3 Tendon Intra-Operative Injury, CTCAE


Locally Advanced Unresectable Digestive System Neuroendocrine Neoplasm

A digestive system neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Grade 2 Associated with Dentures or Dental Prosthesis, CTCAE


Grade 2 Abdomen Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Benign Diencephalic Neoplasm

A benign neoplasm of the diencephalon.


Grade 1 Suicidal Ideation, CTCAE

Increased thoughts of death but no wish to kill oneself


Grade 2 Palmar-Plantar Erythrodysesthesia Syndrome, CTCAE

Skin changes (e.g., peeling, blisters, bleeding, fissures, edema, or hyperkeratosis) with pain; limiting instrumental ADL


Grade 1 Cranial Nerve I Neuropathy, CTCAE


Grade 1 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Anal Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Gastric Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 2 Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage III Prostate Cancer AJCC v8

Stage III includes: IIIA: T1-2, N0, M0, PSA 20 or more, Grade Group 1-4; IIIB: T3-4, N0, M0, PSA: Any, Grade Group 1-4; IIIC: Any T, N0, M0, PSA: Any, Grade Group 5. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. T3: Prostate cancer with extraprostatic tumor that is not fixed or does not invade adjacent structures. T4: Prostate cancer in which the tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. Grade Group 5: Gleason Score 9 or 10, Gleason Pattern 4+5, or 5+4, or 5+5. (AJCC 8th ed.)


Stage IIIB Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage IIIB includes: T3b, N0, M0. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


recurrent gastric cancer

The reemergence of gastric carcinoma after a period of remission.


Grade 3 Weight Gain, CTCAE

>=20% from baseline


Grade 4 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Eosinophilia, CTCAE

>ULN and >Baseline


Grade 2 Jejunal Stenosis, CTCAE

Symptomatic; altered GI function


Grade 3 Stoma GI Stricture or Stenosis, CTCAE


Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Tooth Development Disorder, CTCAE

Asymptomatic; hypoplasia of tooth or enamel


Grade 1 Palpitations, CTCAE

Mild symptoms; intervention not indicated


Chronic superficial gastritis

Persistent inflammation of the superficial portion of the gastric mucosa.  It is a condition that predisposes to the development of ulcer and mucosa-associated lymphoid tissue lymphoma.


Grade 2 Prostate Stricture or Stenosis, CTCAE


Cecal Infection, CTCAE

A disorder characterized by an infectious process involving the cecum.


Grade 5 Vagina Stricture or Stenosis, CTCAE


Grade 2 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 3 Trochlear Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Stage II Pancreatic Neuroendocrine Tumor AJCC v8

Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor limited to the pancreas and measuring 2-4 cm. T3: Tumor limited to the pancreas and measuring more than 4 cm; or tumor invading the duodenum or bile duct. N0: No regional lymph node involvement. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Dermal Change Lymphedema or Phlebolymphedema, CTCAE


Bladder Hemangioma

A hemangioma that arises from the bladder. Most tumors occur in adults.


Primary malignant neoplasm of independent multiple sites

A malignant neoplasm arising in multiple primary sites.


Grade 2 Enterovesical Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Abnormal Glucose Level Finding

A finding that either fasting or postprandial blood glucose levels are above or below the normal thresholds.


Grade 5 Neonatal Pulmonary Hemorrhage, AE

A pulmonary hemorrhage adverse event in a newborn which results in death.


Grade 3 Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Vaginal Infection, CTCAE

Death


Lymphoma/Leukemia by Kiel Classification (Antiquated)


Grade 4 Colon Stricture or Stenosis, CTCAE


Grade 3 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Dysuria, CTCAE

A disorder characterized by painful urination.


Grade 2 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Gastric neuroendocrine carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the stomach. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Pericardial Effusion, CTCAE

A disorder characterized by fluid collection within the pericardial sac, usually due to inflammation.


Grade 4 Spermatic Cord Perforation, CTCAE


Grade 5 Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IIIB Gastric Carcinoma

Stage IIIB includes: (T4b, N0, M0); (T4b, N1, M0); (T4a, N2, M0); (T3, N3, M0).  T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  T4b: Tumor invades adjacent structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Congenital Systemic Disorder

An inherited disorder that presents with systemic manifestations.


Grade 2 Pyramidal Tract Dysfunction, CTCAE


Grade 3 Biliary Tree Stricture or Stenosis, CTCAE


Grade 3 Hepatitis Viral, CTCAE

Symptomatic liver dysfunction; fibrosis by biopsy; compensated cirrhosis; hospitalization or prolongation of existing hospitalization indicated


Grade 3 Ileum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Serum Hypertriglyceridemia, CTCAE


Rash and Dermatitis Associated with Radiation, CTCAE


Gastroesophageal Junction Adenocarcinoma by AJCC v8 Postneoadjuvant Therapy Stage

A term that refers to the postneoadjuvant therapy staging of gastroesophageal junction adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Grade 3 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Vulval intraepithelial neoplasia grade 2

An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by loss of maturation, nuclear hyperchromasia, high nuclear:cytoplasmic ratios, cytological and architectural atypia, and mitoses. Two morphological patterns have been described: basaloid (undifferentiated) and warty (condylomatous, bowenoid). It carries a significant but relatively low risk of progression to squamous cell carcinoma if untreated. (WHO 2020)


Intestinal Stoma Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the contents of the intestinal stoma.


Grade 1 Large Intestinal Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Stage I Cutaneous Melanoma AJCC v6

Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0); (T2a, N0, M0).  T1a: Melanoma is less than or equal to 1.0mm in thickness with or without ulceration.  T1b: Melanoma is less than or equal to 1.0mm in thickness and level IV or V with ulceration. T2a: Melanoma 1.01-2.0 mm in thickness, no ulceration.  N0: No regional lymph node metastasis.  M0: No distant metastasis.-2003


Grade 3 Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Infusion Related Reaction, CTCAE

Mild transient reaction; infusion interruption not indicated; intervention not indicated


Grade 3 Upper Extremity Soft Tissue Necrosis Adverse Event, CTCAE


Cortical Cataract Grade 3

A stage of cortical cataract characterized by 50-90% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Grade 3 Supraventricular Arrhythmia NOS, CTCAE


Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Grade 5 Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


Gastric Schwannoma

A rare schwannoma that arises from the stomach.  It follows a benign clinical course.


Grade 1 Other Musculoskeletal and Soft Tissue, CTCAE


Climacteric arthritis

Arthritis that occurs during menopause.


Grade 5 Pericardial Effusion, CTCAE

Death


Grade 5 Lymph Gland Infection, CTCAE

Death


Grade 1 Neonatal Coagulation Disorder, AE

An adverse event in a newborn characterized by minor biochemical coagulation abnormalities without clinical signs; no care changes indicated.


Grade 2 Vaccination Complication, CTCAE

Moderate pain; Erythema 5.1-10 cm; Induration/swelling 5.1-10 cm; lipodystrophy; limiting instrumental ADL


Advanced Skin Squamous Cell Carcinoma

Skin squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adult Diffuse Astrocytoma

A low grade (WHO grade II) astrocytoma occurring during adulthood.  It is characterized by a high degree of cellular differentiation, slow growth, and diffuse infiltration of neighboring brain structures.


Grade 2 Neonatal Culture Negative Sepsis, AE

An adverse event in a newborn characterized by suspected sepsis with mild or ambiguous signs; anti-infectives initiated.


Grade 1 Sinus Disorder, CTCAE

Asymptomatic mucosal crusting; blood-tinged secretions


Grade 2 Sciatic Nerve Intra-Operative Injury, CTCAE


Recurrent Ependymal Tumor

The reemergence of an ependymal tumor after a period of remission.


Grade 2 Trachea Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage III Vulvar Cancer AJCC v6

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0).  T3: Tumor of any size with contiguous spread to the lower urethra and/or vagina or anus. N1: Unilateral regional lymph node metastasis. M0: No distant metastasis.  (AJCC 6th ed.)


Grade 4 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Myelodysplastic Syndrome, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Thoracic Duct Intra-Operative Injury, CTCAE


Grade 3 Gastrointestinal Stoma Necrosis, CTCAE

Severe symptoms; hospitalization indicated; elective operative intervention indicated


Metastatic malignant neoplasm to anus

An epithelial or non-epithelial malignant neoplasm that has spread to the anus from another anatomic site.


Recurrent Hodgkin Lymphoma

The reemergence of Hodgkin lymphoma after a period of remission.


Neoplastic Nodule

A benign or malignant growth composed of proliferating neoplastic cells.


Grade 5 Dermatitis Radiation, CTCAE

Death


Grade 2 Eye Pain, CTCAE

Moderate pain; limiting instrumental ADL


Lower Gastrointestinal Hemorrhage NOS, CTCAE


Low Grade Anal Intraepithelial Neoplasia

Anal canal or perianal skin intraepithelial neoplasia with mild dysplasia.


Botryoid odontogenic cyst

The multicystic variant of lateral periodontal cyst. (WHO 2017)


Malignant Accessory Urethral Gland Neoplasm

A malignant neoplasm involving the accessory urethral glands.


Lip Or Perioral Area Intra-Operative Injury, CTCAE


Grade 2 Intraoperative Neurological Injury, CTCAE

Partial resection of injured organ/structure indicated


Vaginal Pain

A painful sensation in the vagina.


Condyloma anal

A human papillomavirus-related neoplasm arising from the anus. Morphologically, it is characterized by an exophytic papillary proliferation of squamous cells and acanthosis.


Infective Myositis, CTCAE

A disorder characterized by an infectious process involving the skeletal muscles.


Focal Mammary Duct Ectasia

Localized widening of the lumen of the mammary ducts.


Metastatic Infiltrating Bladder Urothelial Carcinoma, Sarcomatoid Variant

Bladder sarcomatoid variant urothelial carcinoma that has spread to another anatomical site.


Psychosis Including Hallucinations and Delusions, CTCAE


Pitting Edema

Swelling due to excessive accumulation of fluid under the skin defined by a persistent indentation when pressure is applied to the swollen area.  Causes include systemic conditions (e.g., heart failure, liver failure, or kidney failure) and local conditions affecting the extremities.


Grade 1 Bronchospasm, CTCAE

Mild symptoms; intervention not indicated


Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative

A category of juvenile idiopathic arthritis defined by the presence of arthritis affecting five or more separate joints during the first six months of disease, with negative serologic testing for rheumatoid factor.


Childhood L1 Acute Lymphoblastic Leukemia

L1 acute lymphoblastic leukemia that occurs during childhood.


Neoplasm of lacrimal duct

A benign or malignant neoplasm that affects the lacrimal duct.


Sickle Beta Plus Thalassemia

A mild form of sickle cell thalassemia characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells. It is characterized by the presence of small red blood cells and mild anemia.


Grade 4 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Delayed Orgasm, CTCAE

Delay in achieving orgasm not adversely affecting relationship


Hypopituitarism, CTCAE

A disorder characterized by a decrease in production of hormones from the pituitary gland.


Refractory Cervical Squamous Cell Carcinoma, Not Otherwise Specified

Cervical squamous cell carcinoma, not otherwise specified, that is resistant to treatment.


Recurrent Anaplastic (Malignant) Meningioma

The reemergence of anaplastic (malignant) meningioma after a period of remission.


Grade 3 Arteritis Infective, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 1 Non-Infectious Wound Complication, CTCAE


Urostomy Stenosis, CTCAE

A finding of narrowing of the opening of a urostomy.


Metabolic or Respiratory Alkalosis, CTCAE


Biclonal gammopathy

A primary disturbance in immunoglobulin synthesis characterized by the presence of two distinct monoclonal immunoglobulins in the serum or urine.


Vaccination Site Lymphadenopathy, CTCAE

A disorder characterized by lymph node enlargement after vaccination


Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Cyst of biliary tract

A cystic dilatation that occurs in any part of the biliary tree.


Malignant Lymphoma, Large Cell Type

An antiquated term that refers to a morphologic variant of non-Hodgkin lymphoma which is composed predominantly or exclusively of large neoplastic lymphocytes.


Decreased NCF4 Expression

An indication that the expression of NCF4 is lower than the normal range of values.


Grade 5 Stridor, CTCAE

Death


large cell neuroendocrine carcinoma of liver

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver. It is characterized by the presence of malignant large cells.


Grade 5 Spermatic Cord Stricture or Stenosis, CTCAE


Stage IIIA Hepatocellular Carcinoma AJCC v8

Stage IIIA includes: T3, N0, M0. T3: Multiple tumors, at least one of which is larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Spermatic Cord Stricture or Stenosis, CTCAE


Grade 4 Stoma Site Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Cranial Nerve V Motor Intra-Operative Injury, CTCAE


Grade 4 Bladder Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Dyspepsia, CTCAE

Severe symptoms; operative intervention indicated


Adverse Event Associated with Metabolic and Laboratory Abnormalities


Grade 2 Hot Flashes, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 4 Acidosis, CTCAE

Life-threatening consequences


Grade 4 Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Fall, CTCAE

Hospitalization indicated; invasive intervention indicated


Bladder Sphincter Dysfunction

Non-coordinated, reflexive contraction of the bladder and sphincter relaxation.


Grade 1 Pain, CTCAE

Mild pain


Injury of lumbar spinal cord

An injury to the lumbar spinal cord.


Grade 1 Dysarthria, CTCAE

Mild slurred speech


Grade 2 Cranial Nerve XII Intra-Operative Injury, CTCAE


Congenital supraventricular tachycardia

A disorder present at birth characterized by an electrocardiographic finding of a tachycardia that originates above the ventricles.


Grade 5 Wound Complication, CTCAE

Death


Recurrent Diffuse Astrocytoma

The reemergence of diffuse astrocytoma after a period of remission.


Refractory Malignant Bone Neoplasm

Malignant bone neoplasm that is resistant to treatment.


Small Hepatocellular Carcinoma

Hepatocellular carcinoma measuring equal to or less than 2 cm in diameter. It includes early hepatocellular carcinoma and small progressed hepatocellular carcinoma.


Grade 3 Personality and Behavioral Change, CTCAE


Grade 1 Rash Hand or Foot Skin Reaction, CTCAE


Grade 2 Intraoperative Arterial Injury, CTCAE

Partial resection of injured organ/structure indicated


Gallbladder Papillary Adenoma

An adenoma that arises from the gallbladder.  It is characterized by the presence of a papillary growth pattern.


Recurrent Aplastic Anemia

The reemergence of aplastic anemia after a period of remission.


Grade 2 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Vaginal Mucinous Adenocarcinoma, Gastric-Type

Vaginal mucinous adenocarcinoma characterized by the presence of gastric differentiation.


Aromatic Dyes-Related Malignant Neoplasm


Childhood Glioblastoma

A glioblastoma that occurs during childhood.


Precursor T-lymphoblastic lymphoma/leukemia stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (Rare in Hodgkin lymphoma).


Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Adult Primary Meningeal Melanocytic Neoplasm

A primary meningeal melanocytic neoplasm that occurs in adults.


Radiating Chest Pain Along Left Anterior Axillary Line

The location of the radiating chest pain is along the left anterior axillary line.


Stage II Prostate Cancer AJCC v6

Stage II includes: (T1a, N0, M0, G2, 3-4); (T1b, N0, M0, Any G); (T1c, N0, M0, Any G); (T1, N0, M0, Any G); (T2, N0, M0, Any G).  T1: Clinically inapparent tumor neither palpable nor visible by imaging.  T1a: Tumor incidental histologic finding in 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g. because of elevated PSA).  T2: Tumor confined with in the prostate.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G2: Moderately differentiated (moderate anaplasia) (Gleason 5-6). G 3-4: Poorly differentiated/undifferentiated (marked anaplasia) (Gleason 7-10).  (AJCC 6th ed.)


Grade 4 Vomiting, CTCAE

Life-threatening consequences


Treatment related leukaemia

A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor or exposure to ionizing radiation.


Grade 3 Neutrophils and Granulocytes, CTCAE


Grade 3 Perineal Pain, CTCAE

Severe pain; limiting self care ADL


Grade 4 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Retina Intra-Operative Injury, CTCAE


Grade 4 Non-Malignant Pericardial Effusion, CTCAE


Grade 1 Cardiac Troponin I Increased, CTCAE

Levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer


Trochlear Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the trochlear nerve (fourth cranial nerve).


Grade 2 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Adult Grade II Meningioma

A grade II meningioma that occurs during adulthood.


Appendix High Grade Intraepithelial Neoplasia

A precancerous intraepithelial neoplastic lesion that affects the appendix.  It is characterized by the presence of moderate or severe dysplasia and complex architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


Metastatic Vulvar Squamous Cell Carcinoma

Vulvar squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


Grade 3 Lymphocele, CTCAE

Severe symptoms; invasive intervention indicated


46,XY Ovotesticular Differences of Sex Development

The presence of ovarian and testicular tissue in the an individual with 46,XY karyotype. The anatomical expression of this condition is variable.


Serum CA 19-9 Elevated

The amount of cancer antigen 19-9 present in a serum sample is elevated.


Grade 2 Anal Sphincter Intra-Operative Injury, CTCAE


Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Verrucous carcinoma of the oral cavity stage III


Grade 3 Otitis Middle Ear Non Infectious, CTCAE


Conjunctival Junctional Nevus

A junctional nevus that arises from the conjunctiva. It occurs almost exclusively in the juxtalimbal bulbar conjunctiva. It is characterized by an intraepithelial proliferation of type A nevus cells and/ or type B nevus cells.


Grade 4 Intraoperative Splenic Injury, CTCAE


Grade III Childhood Astrocytoma

An anaplastic astrocytoma that arises from the central nervous system and occurs during childhood.


Grade 2 Anal Ulcer, CTCAE

Symptomatic; altered GI function


Monomorphic T/NK-Cell Post-Transplant Lymphoproliferative Disorder

A clonal T-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed T-lymphocytes/NK-cells.  The clonal cellular infiltrates fulfill the criteria for any of the T-cell or natural killer cell lymphomas.


Unresectable Fibrolamellar Carcinoma

A fibrolamellar carcinoma that is not amenable to surgical resection.


Grade 3 Renal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 2 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Small Bowel Stricture or Stenosis NOS, CTCAE


Grade 2 Endophthalmitis, CTCAE

Local intervention indicated


Grade 4 Scleral Necrosis and Melt, CTCAE


Grade 2 Salivary Duct Inflammation, CTCAE

Thick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms; limiting instrumental ADL


Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps), CTCAE


Grade 5 Small Intestinal Stenosis, CTCAE

Death


Grade 3 Bone Marrow Hypocellular, CTCAE

Severely hypocellular or >50-<=75% reduction cellularity from normal for age


Grade 4 Slipped Capital Femoral Epiphysis, CTCAE


Grade 4 Gastric Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Refractory Squamous Cell Carcinoma

Squamous cell carcinoma that is resistant to treatment.


Grade 4 Intraoperative Arterial Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Congenital Adrenal Gland Disorder

A genetic disorder that affects the adrenal gland.  It includes adrenal gland hyperplasia and adrenal gland hypoplasia.


Non-Neoplastic Gonadal Disorder

A non-neoplastic disorder that affects the testis or the ovary. Representative examples include gonadal agenesis, dysgenesis, and hypogonadism.


Grade 5 Neonatal Respiratory Distress Syndrome, AE

A respiratory distress adverse event in a newborn which results in death.


Stage IV Renal Pelvis and Ureter Cancer AJCC v7

Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  N1: Distant metastasis.  (AJCC 7th ed.)


Lower Gastrointestinal Hemorrhage, CTCAE

A disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus).


Schizophrenia, Childhood

Schizophrenia occurring in childhood.


Grade 4 Muscle Intra-Operative Injury, CTCAE


Grade 1 Pancreatic Enzymes Decreased, CTCAE

<LLN and asymptomatic


Invasive Prostate Carcinoma

A carcinoma that is not confined to the prostatic epithelium but has spread to the surrounding stroma of the prostate gland.  The vast majority of invasive prostate carcinomas are adenocarcinomas.


Grade 2 Conjunctivitis Infective, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Retroperitoneal disorder

A non-neoplastic or neoplastic disorder that affects the retroperitoneum.


Non-Neoplastic Anal Disorder

A non-neoplastic disorder that affects the anus. Representative examples include hemorrhoids, ulcers, and infections.


Ileus, CTCAE

A disorder characterized by failure of the ileum to transport intestinal contents.


Grade 2 Gastrointestinal Stoma Leak, CTCAE


Grade 1 Chronic Kidney Disease, CTCAE

eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) <LLN-60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5


Grade 2 Carbon Monoxide Diffusing Capacity Decreased, CTCAE

6-8 units below LLN; for follow-up, an asymptomatic decrease of >5-8 units (ml/min/mm Hg) below the baseline value; symptomatic and intervention not indicated


Grade 4 Delusions, CTCAE

Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Grade 2 Uterus Intra-Operative Injury, CTCAE


Grade 5 Vein Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Personality and Behavioral Change, CTCAE


Grade 2 Suicidal Ideation, CTCAE

Suicidal ideation with no specific plan or intent


Benign Accessory Urethral Gland Neoplasm

A benign neoplasm arising from the accessory urethral glands.


Trigeminal Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the trigeminal nerve (fifth cranial nerve).


Grade 4 Upper Extremity Soft Tissue Necrosis Adverse Event, CTCAE


Grade 1 Testes Stricture or Stenosis, CTCAE


Grade 5 Gastric Perforation, CTCAE

Death


Genitourinary Stoma Stricture or Stenosis, CTCAE


Stage 0 Intrahepatic Bile Duct Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ (intraductal tumor). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage II Non-Contiguous Adult Diffuse Mixed Cell Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Childhood Ependymal Tumor

An ependymal tumor that occurs during childhood.


Recurrent Fallopian Tube High Grade Serous Adenocarcinoma

The reemergence of fallopian tube high-grade serous adenocarcinoma after a period of remission.


Grade 1 Nipple Deformity, CTCAE

Asymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex


Stage II Anal Cancer AJCC v8

Stage II includes: IIA: T2, N0, M0; IIB: T3, N0, M0. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Middle Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Pancreatic Cancer AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


Aggressive Prostate Adenocarcinoma

Prostate adenocarcinoma that metastasizes quickly to other anatomic sites. It usually has a Gleason score between 8 and 10, a PSA level higher than 20 ng/ml, and is classified as T3b or T4.


Stage IVC Oral Cavity Verrucous Carcinoma


Grade 3 Neonatal Respiratory Distress Syndrome, AE

An adverse event in a newborn characterized by clinical evidence of increased respiratory distress with relevant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); requiring major care change (e.g. starting invasive support).


Grade 5 Esophageal Obstruction, CTCAE

Death


Kidney Neuroendocrine Neoplasm

An epithelial neoplasm with neuroendocrine differentiation that arises from the kidney.  It includes neuroendocrine tumor, small cell neuroendocrine carcinoma, large cell neuroendocrine carcinoma, and paraganglioma.


Cancer-Associated Anorexia

Loss of appetite associated with cancer or its treatment.


Locally Advanced Merkel Cell Carcinoma

Merkel cell carcinoma that has spread to nearby tissues or lymph nodes.


Grade 1 Renal and Urinary Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Advanced Mucosal Melanoma

Mucosal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Pruritus, CTCAE

Widespread and constant; limiting self care ADL or sleep; systemic corticosteroid or immunosuppressive therapy indicated


Grade 1 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Grade 2 Bladder Spasm, CTCAE

Antispasmodics indicated


Grade 3 Hallucinations, CTCAE

Severe hallucinations; hospitalization not indicated


Grade 4 Ureteric Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Proctitis, CTCAE

Death


Schizophrenia, Disorganized

A subtype of schizophrenia characterized by disorganized speech, disorganized behavior, and a flat or inappropriate affect; associated features include grimacing, mannerisms, and other oddities of behavior. Criteria for the catatonic type of schizophrenia are not met.


Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


Cervical Stratified Mucin-Producing Intraepithelial Lesion

A rare, human papillomavirus-associated premalignant glandular intraepithelial neoplasm that arises from the cervix. It is characterized by the presence of stratiﬁed, immature epithelial cells containing varying quantities of intracytoplasmic mucin. There is no evidence of stromal invasion. It is distinct from conventional cervical squamous or glandular intraepithelial neoplasias.


Metanephric Tumor

A neoplasm arising from the distal convoluted tubule and collecting duct areas of the kidney.


Localized Neoplasm

A neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Complication of transplant

A problem arising from transplantation.


COVID-19-Associated Hematuria

Hematuria caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Benign neuroendocrine tumor

A paraganglioma that is confined to the site of origin.


Continent Epispadias

Epispadias with urinary continence.


Therapy-Related Toxicity - Acceptable to Patient

Indicates that a toxicity adverse effect has been experienced by a patient, but it is not severe enough for the patient to discontinue the treatment.


Ann Arbor Stage I Supradiaphragmatic Hodgkin Lymphoma


stenosis of supravalvular pulmonary artery

Stenosis of the pulmonary artery that occurs above the valve.


Stage I Esophageal Cancer

Stage I includes: T1, N0, M0.  TI: Tumor invades lamina propria or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) -2003


Grade 4 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Periorbital Edema, CTCAE

Indurated or pitting edema; topical intervention indicated


Grade 2 Anorectal Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 3 Lower Extremity Soft Tissue Necrosis, CTCAE


Abscess of adrenal gland

An abscess that is located in the adrenal gland.


Grade 4 Cecum Intra-Operative Injury, CTCAE


Grade 4 Encephalomyelitis Infection, CTCAE


Grade 5 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Enteropathic spondylitis

A form of spondyloarthritis that is found in some patients with inflammatory bowel disease.


Neck Edema

Swelling due to an accumulation of excessive fluid in the neck.


Adult Acute Erythroid Leukemia

An acute erythroid leukemia occurring in adults.


Metastatic malignant neoplasm to epididymis

A malignant neoplasm that has metastasized to the epididymis from another anatomic site.


Cervical Adenocarcinoma, Not Otherwise Specified

A cervical adenocarcinoma that cannot be classified by WHO criteria or International Endocervical Adenocarcinoma Criteria and Classification (IECC).