Pathologic Stage I Retinoblastoma AJCC v8

Stage I includes: pT1, pT2, pT3, pN0, cM0, Any H. pT1: Intraocular tumor(s) without any local invasion, focal choroidal invasion, or pre-or intralaminar involvement of the optic nerve head. pT2: Intraocular tumor(s) with local invasion. pT3: Intraocular tumor(s) with significant local invasion. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Grade 2 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

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Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Lacrimal Drainage System Non-Keratinizing Squamous Cell Carcinoma

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A squamous cell carcinoma of the lacrimal drainage system characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.


Grade 2 Vaginitis Not Due to Infection, CTCAE


Breast Atrophy, CTCAE

A disorder characterized by underdevelopment of the breast.


Refractory Urinary System Carcinoma

Urinary system carcinoma that does not respond to treatment.


Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Recurrent Malignant Male Reproductive System Neoplasm

Reemergence of a malignant male reproductive system neoplasm after a period of remission.


Enterovesical Fistula, CTCAE

A disorder characterized by an abnormal communication between the urinary bladder and the intestine.


Grade 3 Induration or Fibrosis of the Skin and Subcutaneous Tissue, CTCAE


Lipohypertrophy, CTCAE

A disorder characterized by hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin.


Infiltrating Bladder Urothelial Carcinoma with Squamous Differentiation

An invasive transitional cell carcinoma of the bladder that exhibits squamous differentiation.


Grade 2 Superficial Thrombophlebitis, CTCAE

Present


Grade 2 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Thyroid colloid nodule

A non-cancerous thyroid gland nodule that contains colloid material.


Grade 3 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Agitation, CTCAE 5.0

A disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension.


Clinical Stage I Retinoblastoma AJCC v8

Stage I includes: cT1, cT2, cT3, cN0, cM0, Any H. cT1: Intraretinal tumor(s) with subretinal fluid 5 mm or less from the base of any tumor. cT2: Intraocular tumor(s) with retinal detachment, vitreous seeding, or subretinal seeding. cT3: Advanced intraocular tumor(s). cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Papillary serous cystadenoma

A serous benign or low malignant potential cystic epithelial neoplasm characterized by the presence of glandular epithelial cells forming papillary structures.


Steroid Resistant Acute Graft Versus Host Disease

Acute graft versus host disease that is resistant to treatment with steroids.


Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Fallopian Tube Metaplastic Papillary Tumor

A rare metaplastic lesion that arises from the fallopian tube. It is characterized by the presence of an intraluminal papillary proliferation composed of atypical epithelial cells with abundant eosinophilic cytoplasm. In the vast majority of cases, it is an incidental finding during microscopic examination of a fallopian tube in the postpartum period.


Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Malignant Solid Neoplasm

A malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include carcinomas and sarcomas. Hematopoietic and lymphoid tissue malignancies are not considered solid neoplasms.


Recurrent Fallopian Tube Carcinoma

The reemergence of fallopian tube carcinoma after a period of remission.


Grade 1 Ascites, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 CNS Necrosis and Cystic Progression, CTCAE


Premalignant Neoplasm

A neoplasm that is composed of dysplastic cells and there is no morphologic evidence of infiltration of the surrounding tissues.


Non-Neoplastic Disorder by Special Category


ROSE Cluster 1

Gene expression cluster 1 as determined by Recognition of Outliers by Sampling Ends (ROSE) in high-risk B-precursor acute lymphoblastic leukemia.


Recurrent Nervous System Neoplasm

The reemergence of a nervous system neoplasm after a period of remission.


Astler-Coller C1 Colon Carcinoma

Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


Refractory T-Cell Large Granular Lymphocyte Leukemia

T-cell large granular lymphocyte leukemia that is resistant to treatment.


Hereditary Malignant Neoplasm

Malignant neoplasms occurring in families at a rate greater than that expected by chance and caused by germline mutations in a specific gene.


Occlusion of inferior vena cava

Blockage of the lumen of the inferior vena cava.


Lugano Classification Advanced Stage Adult Lymphoma AJCC v8

Advanced stage adult lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Radiation Recall Reaction (Dermatologic), CTCAE

Life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated


Monogenic Hyperinsulinism

A genetically heterogenous group of hyperinsulinemic conditions caused by mutation(s) in one of the many genes involved in the regulation of insulin secretion.


Genitourinary Stricture and Stenosis Including Anastomotic Stricture and Stenosis, CTCAE


Cervix carcinoma recurrent

The reemergence of cervical carcinoma after a period of remission.


Grade 4 Neck Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Infections and Infestations - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 2 Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ectopic ureter

A congenital anomaly in which the ureteral orifice drains into an abnormal location.


Grade 1 Jejunum Intra-Operative Injury, CTCAE


Grade 5 Phrenic Nerve Dysfunction, CTCAE


Endometrial Endometrioid Adenocarcinoma with Clear Cell Change

A morphologic variant of endometrioid adenocarcinoma characterized by the presence of large multinucleated clear cells.


Extended Oligoarticular Juvenile Idiopathic Arthritis

Oligoarticular juvenile idiopathic arthritis that eventually involves more than four separate joints.


Grade 3 Arterial Thromboembolism, CTCAE

Urgent intervention indicated


Staphylococcal arthritis and polyarthritis


Recurrent Diffuse Midline Glioma, H3 K27M-Mutant

The reemergence of diffuse midline glioma, H3 K27M mutant, after a period of remission.


Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Grade 2 Prolonged Intubation After Pulmonary Resection, CTCAE


Neoplasm of lacrimal drainage system

A benign or malignant neoplasm that affects the lacrimal drainage system.


Grade 5 Stoma GI Stricture or Stenosis, CTCAE


Grade 5 Cervix Infection with Unknown Absolute Neutrophil Count, CTCAE


Ovarian Infection

An infectious process affecting the ovary.


Stage II Contiguous Adult Diffuse Mixed Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 3 Colonic Obstruction, CTCAE

Hospitalization indicated; invasive intervention indicated


Occupational Malignant Neoplasm

Malignant neoplasm secondary to occupational exposure to carcinogens.


Stage IVB Hepatocellular Carcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Grade 1 Arterial Injury, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Neonatal Diarrhea, AE

An adverse event in a newborn characterized by watery bowel movements.


Grade 2 Ileum Intra-Operative Injury, CTCAE


Grade 2 Neonatal Gastrointestinal Bleeding, AE

A gastrointestinal bleeding adverse event in a newborn characterized by moderate bleeding; minor change in care or monitoring required.


Grade 5 Sinusoidal Obstruction Syndrome, CTCAE

Death


Neuroendocrine cervical carcinoma

A malignant, high grade neuroendocrine neoplasm that arises from the cervix. This category includes small cell and large cell neuroendocrine carcinoma.


Grade 1 Eye Pain, CTCAE

Mild pain


Verrucous carcinoma of the oral cavity stage IV


Supratentorial Meningioma

A meningioma that affects the supratentorial brain.


Childhood Myxopapillary Ependymoma

A myxopapillary ependymoma that occurs during childhood.


Grade 5 Rectal Varices Hemorrhage, CTCAE


Biliary Tree Stricture or Stenosis, CTCAE


Grade 3 Testes Stricture or Stenosis, CTCAE


Grade 5 Gastrointestinal Stoma Leak, CTCAE


Grade 2 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Glassy cell carcinoma

A malignant epithelial neoplasm composed of atypical cells with glassy cytoplasm.


Early Hepatocellular Carcinoma

A low grade, well differentiated small hepatocellular carcinoma. It lacks obvious stromal invasion and significant atypia.


Grade 4 Ileum Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IIC Fallopian Tube Cancer AJCC v6 and v7

Stage IIC includes: T2c, N0, M0.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Pruritus, CTCAE

A disorder characterized by an intense itching sensation.


Grade 4 Vagus Nerve Disorder, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Glossopharyngeal Nerve Disorder, CTCAE


Low grade appendiceal mucinous neoplasm

A well differentiated mucinous neoplasm that arises from the appendix.  It is characterized by slow growth and it is associated with the development of pseudomyxoma peritonei.


Grade 5 Biliary Tract Infection, CTCAE

Death


Distress

A state of physiological or psychological stress that cannot be compensated for by normal adaptive measures.


Genitourinary System Neoplasm

A benign or malignant neoplasm that affects the genitourinary system.


Gastrointestinal Stoma Hemorrhage, CTCAE


Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Patient Allergic to Contrast Media

Patient identified to be at risk for an allergic reaction to contrast media.


Grade 2 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Urethral Cancer by AJCC v8 Stage

A term that refers to the staging of urethral cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to urothelial (transitional cell), squamous, and glandular carcinomas of the urethra and to urothelial (transitional cell) carcinomas of the prostate and prostatic urethra. It does not apply to squamous cell carcinomas of the penile foreskin (are staged according to the classification for penis), primary urothelial carcinomas of the bladder with transmural involvement of the prostate (are staged according to the classification for urinary bladder), prostatic adenocarcinomas (are staged according to the classification for prostate), mucosal melanomas of the urethra (no AJCC staging system), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs).  (from AJCC 8th Ed.)


Diffuse Non-Pontine Midline Glioma

A diffuse glioma that arises from the midline structures of the central nervous system, other than the pons.


Grade 1 Movements Involuntary, CTCAE

Mild symptoms


Grade 2 Alopecia, CTCAE

Hair loss of >=50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact


Grade 3 Portal Vein Thrombosis, CTCAE

Medical intervention indicated


Ejection Fraction Decreased, CTCAE

The percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction.


Skin and Subcutaneous Tissue Disorders, CTCAE


Perihepatic abscess

An abscess that is located in the anatomical space surrounding the liver, but which is outside of the liver capsule itself.


Panniculitis Ossificans

A condition characterized by subcutaneous fat necrosis with heterotopic calcification. It often occurs as a result of injury to the area.


Recurrent Fallopian Tube Clear Cell Adenocarcinoma

The reemergence of fallopian tube clear cell adenocarcinoma after a period of remission.


Astler-Coller B3 Rectal Carcinoma

Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.)


Vaginal Mucinous Adenocarcinoma, Intestinal-Type

A vaginal mucinous adenocarcinoma that resembles the large intestinal adenocarcinoma.


Fallopian Tube Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures).


Grade 4 Hepatic Necrosis, CTCAE

Life-threatening consequences; urgent invasive intervention indicated


Meningeal Leukemia

Infiltration of the meninges by an acute or chronic leukemia.


Locally Advanced Malignant Mesothelioma

Malignant mesothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acquired hydrocephalus

Hydrocephalus that results from head trauma, brain tumors, intracranial hemorrhage, or meningitis.


Recurrent Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

The reemergence of undifferentiated high grade pleomorphic sarcoma of bone in childhood after a period of remission.


Grade 4 Thromboembolic Event, CTCAE

Life-threatening consequences with hemodynamic or neurologic instability


Grade 2 Activated Partial Thromboplastin Time Prolonged, CTCAE

>1.5-2.5 x ULN


Aspartate Aminotransferase Increased, CTCAE

A finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen.


Grade 4 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Epstein-Barr Virus Infection Reactivation, CTCAE

Death


Grade 2 Nail Loss, CTCAE

Symptomatic separation of the nail bed from the nail plate or nail loss; limiting instrumental ADL


Refractory Adult Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia that occurs in adulthood and does not respond to treatment.


Grade 4 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage II Extragonadal Non-Seminomatous Germ Cell Tumor


Myxoid Pleomorphic Liposarcoma

An exceptionally rare, aggressive adipocytic neoplasm, typically occurring in children and adolescents. Myxoid pleomorphic liposarcoma shows mixed histological features of conventional myxoid liposarcoma and pleomorphic liposarcoma and lacks the gene fusions and amplifications of myxoid liposarcoma, atypical lipomatous tumor, and dedifferentiated liposarcoma. (WHO 2020)


Grade 2 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Seroma, CTCAE

Symptomatic, elective invasive intervention indicated


Pediatric Non-Congenital Ventricular Tachycardia

A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin that was not present at birth in an individual under age 21. The QRS complexes are wide and have an abnormal morphology.


Grade 1 Edema Trunk, CTCAE

Swelling or obscuration of anatomic architecture on close inspection


Grade 3 Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Esophageal carcinoma recurrent

An esophageal carcinoma which has reappeared after a period of remission or after presumed treatment.


Stage II Fallopian Tube Cancer

Stage II includes: (T2, N0, M0); IIA: (T2a, N0, M0); IIB (T2b, N0, M0); IIC (T2c, N0, M0).  T2: Tumor involves one or both fallopian tubes with pelvic extension.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  T2b: Extension to other pelvic structures.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Hyperviscosity

An increase in the viscosity of blood resulting from an increase in the proportion of cellular elements of the blood, a change in the mechanical properties of the cellular elements of the blood, and/or an alteration in plasma viscosity.


Stage IB Cervical Cancer AJCC v6 and v7

Stage IB includes: IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Neonatal Hypertension, AE

A hypertensive adverse event in a newborn which results in death.


Perceptual Distortion

An incorrect understanding or interpretation of sensory input.


Aplastic Anemia due to Hepatitis

Bone marrow failure defined as pancytopenia, secondary to hepatitis.


Grade 4 Suicide Attempt, CTCAE

Suicide attempt with intent to die which requires hospitalization


Metastatic High Grade Sarcoma

High grade sarcoma that has spread from its original site of growth to another anatomic site.


benign granular cell tumor of gallbladder

A non-metastasizing neoplasm arising from the gallbladder.  It is characterized by the presence of large polygonal cells with abundant granular cytoplasm.


Grade 2 Tracheal Mucositis, CTCAE

Moderate symptoms; medical intervention indicated; limiting instrumental ADL


Reticulosarcoma of spleen

An antiquated term that refers to a non-Hodgkin lymphoma composed of diffuse infiltrates of large, often anaplastic lymphocytes affecting the spleen.


Grade 2 Chylothorax, CTCAE

Symptomatic; medical intervention indicated (e.g., fat-restricted diet); thoracentesis or tube drainage indicated


Cervical Neuroendocrine Tumor G2

A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the cervix.


Grade 3 Parotid Gland Intra-Operative Injury, CTCAE


Grade 4 Investigations - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Ancylostomiasis due to Ancylostoma braziliense (disorder)

Infection by Ancylostoma braziliense.


Grade 3 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Otitis External Ear Non Infectious, CTCAE


Grade 2 Lymphocyte Count Decreased, CTCAE

<800-500/mm3; <0.8-0.5 x 10e9/L


Breast Schwannoma

A schwannoma that arises from the breast.


Pharyngitis, CTCAE

A disorder characterized by inflammation of the throat.


Grade 4 Intraoperative Renal Injury, CTCAE


Grade 3 Esophageal Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Grade 2 Hemorrhoidal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Metastatic Cervical Adenocarcinoma

A cervical adenocarcinoma that has spread to another anatomic site.


Refractory Cutaneous Melanoma

Melanoma of the skin that is resistant to treatment.


Grade 2 Vomiting, CTCAE

Outpatient IV hydration; medical intervention indicated


Decreased Concomitant Drug Half Life

Decreased period of time required for the concentration or amount of a concomitant drug in the body to be reduced to exactly one-half of a given concentration or amount.


Gastrointestinal disorder congenital

An abnormality of the digestive system that is present at birth or detected in the neonatal period.


Grade 2 Edema Face, CTCAE

Moderate localized facial edema; limiting instrumental ADL


Structural Heart Abnormality

An anatomic deformity of the heart, ventricles or great vessels


Retinal arteriovenous malformation

A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the retina.


Grade 1 Tinnitus, CTCAE

Mild symptoms; intervention not indicated


Foreign body granuloma of muscle

An inflammatory lesion in the muscle comprised of epithelioid histiocytes and chronic inflammation that is caused by the presence of extraneous material .


Refractory Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma that is resistant to treatment.


Recurrent EBV-Related Lymphoma

The reemergence of EBV-related lymphoma after a period of remission.


Grade 4 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Paratesticular Adenomatoid Tumor

An adenomatoid tumor arising from the paratesticular structures. It is the most common tumor of the paratesticular region. The tail of the epididymis is the most common site of involvement.


Perforation Bile Duct, CTCAE

A disorder characterized by a rupture in the wall of the extrahepatic or intrahepatic bile duct.


Grade 3 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Belching, CTCAE

To expel gas noisily from the mouth.


Pancreatic adenocarcinoma metastatic

An adenocarcinoma that arises from the exocrine pancreatic tissue and has metastasized to other anatomic sites.


A lymphoproliferative disorder that develops in an individual with HIV infection.


Diabetic foetopathy

A constellation of features seen in the hyperinsulinemic fetus of a diabetic mother that include macrosomia, postnatal hypoglycemia and polycythemia.


Glioneuronal Tumor with Neuropil-Like Islands

A rare, WHO grade II or III infiltrating astrocytoma characterized by the presence of sharply demarcated foci, composed of a neuropil-like matrix.


Stage IIIC Esophageal Cancer AJCC v7

Stage IIIC includes: For squamous cell carcinoma: (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 5 Respiratory Failure, CTCAE

Death


Grade 4 Cranial Nerve VII Neuropathy, CTCAE


Grade 3 Hyperphosphatemia, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated


Grade 5 Jejunal Obstruction, CTCAE

Death


Extrahepatic Bile Duct Neuroendocrine Tumor

A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts.


Grade 3 Febrile Neutropenia, CTCAE

ANC <1000/mm3 with a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour


Grade 4 Pregnancy Loss, CTCAE

Fetal loss at any gestational age


Grade 5 Gastrointestinal Disorders - Other, Specify, CTCAE

Death


Grade 2 Constipation, CTCAE

Persistent symptoms with regular use of laxatives or enemas; limiting instrumental ADL


Grade 2 Other Constitutional Symptoms, CTCAE


Malignant Outer Hair Sheath and Infundibulum Neoplasm

A malignant neoplasm that arises from the outer hair sheath and infundibulum.


Radiation Recall Reaction (Dermatologic), CTCAE

A finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent.


Type III Total Anomalous Pulmonary Venous Return

Total anomalous pulmonary venous return in which the common pulmonary vein connects to the portal venous system through the diaphragm.


Stage IIA Bone Sarcoma AJCC v7

Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 3 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Penis Intra-Operative Injury, CTCAE


Grade 2 Pharynx Intra-Operative Injury, CTCAE


Grade 3 Uterine Perforation, CTCAE

Invasive intervention indicated


Grade 3 Hemorrhoids, CTCAE

Severe symptoms; invasive intervention indicated


Prostate Infection, CTCAE

A disorder characterized by an infectious process involving the prostate gland.


Grade 3 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Conjunctivitis, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


Upper Extremity Artery Intra-Operative Injury, CTCAE


Grade 4 Scrotum Intra-Operative Injury, CTCAE


Peripheral Nerve Injuries

Sensory or motor loss of peripheral nerve function due to a traumatic event. (ACC)


Myopathy Secondary to Glycogen Storage Disorder

A myopathy that was caused by a primary disorder of glycogen storage.


Lacrimal Gland Oncocytic Adenocarcinoma

An adenocarcinoma that arises from the lacrimal gland. It is characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm.


Grade 4 Dental-Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Adverse Event Associated with Hemorrhage and Bleeding


Ann Arbor Stage II Supradiaphragmatic Nodular Lymphocyte Predominant Hodgkin Lymphoma


Hodgkin's disease of intrapelvic lymph nodes

Stage I Hodgkin lymphoma involving the subdiaphragmatic region.


Vulvar Yolk Sac Tumor

A rare yolk sac tumor that arises from the vulva.


Grade 4 Vulval Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Intraoperative Arterial Injury, CTCAE

A finding of damage to an artery during a surgical procedure.


Grade 1 Gingiva Intra-Operative Injury, CTCAE


Grade 2 Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic malignant neoplasm to testis

A malignant neoplasm that has spread to the testis from another anatomic site.


Radiation retinopathy

Injury of the retina following exposure to radiation.  The retinal injury results from occlusive microangiopathy caused by endothelial cell loss.


Stage 0 Vulvar Cancer

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma). N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Grade 2 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Jejunal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Chest Pain in Right Fourth Intercostal Space

The location of the chest pain is within the fourth intercostal space on the right side.


Grade 5 Laryngeal Obstruction, CTCAE

Death


Fibroblastic reticular cell neoplasm

A very rare dendritic cell tumor affecting the lymph nodes, spleen, and soft tissues. Morphologically it is similar to the interdigitating dendritic cell sarcoma or follicular dendritic cell sarcoma. The tumor cells are positive for cytokeratin and CD68. Clinical outcome is variable.


Bacterial Toxemia

The condition resulting from the spread of bacterial products (toxins) by the bloodstream.


Nail Ridging, CTCAE

A disorder characterized by vertical or horizontal ridges on the nails.


Slipped extraocular muscle

Weakness of extraocular muscle function as a result of inadequate securing of the muscle to the sclera during strabismus surgery.


Excessive weight gain in pregnancy

In a woman with a normal weight pre-pregnancy body mass index (BMI), i.e. 18.5-24.9, the weight gained during pregnancy exceeds a total weight gain of 35 lbs. In a woman with an underweight pre-pregnancy body mass index (BMI), i.e. less than 18.5, the weight gained during pregnancy exceeds a total weight gain of 40 lbs. In a woman with an overweight pre-pregnancy body mass index (BMI), i.e. 25.0-29.9, the weight gained during pregnancy exceeds a total weight gain of 25 lbs. In a woman with an obese pre-pregnancy body mass index (BMI), i.e. greater than 30, the weight gained during pregnancy exceeds a total weight gain of 20 lbs. These standards are supported for the whole population irrespective of height, race or ethnicity.


Grade 3 Reproductive System and Breast Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 3 Hip Fracture, CTCAE

Severe pain; hospitalization or intervention indicated for pain control (e.g., traction); operative intervention indicated


Stage IIIA1 Fallopian Tube Cancer AJCC v8

Stage IIIA1 includes: T1/2, N1, M0. T1: T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Grade 4 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Adult Acute Myelomonocytic Leukemia

An acute myelomonocytic leukemia occurring in adults.


Grade 2 Other Allergy and Immunology, CTCAE


Grade 2 Anemia, CTCAE

Hgb <10.0-8.0 g/dL; <6.2-4.9 mmol/L; <100-80g/L


Viremia

A laboratory test result indicating the presence of a virus in the blood.


Grade 5 Left Ventricular Diastolic Dysfunction, CTCAE


Locally Recurrent Merkel Cell Carcinoma

The reemergence of Merkel cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Uterine Hemorrhage, CTCAE

A disorder characterized by bleeding from the uterus.


Clinical Stage IIA Cutaneous Melanoma AJCC v8

Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Neonatal Fever, AE

A febrile adverse event in a newborn characterized by life-threatening consequences.


Grade 1 Tracheal Obstruction, CTCAE

Partial asymptomatic obstruction on examination (e.g., visual, radiologic or endoscopic)


Grade 3 Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Toothache, CTCAE

Moderate pain; limiting instrumental ADL


Grade 5 Vaginal Anastomotic Leak, CTCAE

Death


Grade 2 Urinary Electrolyte Wasting, CTCAE


Grade 3 Esophageal Varices Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 3 Urethral Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Deletion of Chromosome 3p Associated Meningioma

A meningioma that is associated with deletion of chromosomal arm 3p.


Grade 4 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Bone Intra-Operative Injury, CTCAE


Metastatic Peritoneal Malignant Mesothelioma

Peritoneal malignant mesothelioma that has spread from its original site of growth to another anatomic site.


Prostate Acinar Adenocarcinoma, Pseudohyperplastic Variant

A variant of acinar prostate adenocarcinoma characterized by the presence of neoplastic large glands that resemble the benign, non-neoplastic prostate glands.


Grade 4 Neonatal Pulmonary Hemorrhage, AE

A pulmonary hemorrhage adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise.


Grade 5 Peripheral Motor Neuropathy, CTCAE

Death


Sperm granuloma

A lump of extravasated sperm in the paratesticular region in men who have undergone vasectomy.


Grade 2 Other Hepatobiliary and Pancreas, CTCAE


Other Finding

An additional finding not previously noted.


Malignant neoplasm occurring in immunodeficient patients.


Wound Dehiscence, CTCAE

A finding of separation of the approximated margins of a surgical wound.


Hydroxyproline Urine Increased

A laboratory test result indicating abnormally high concentration of hydroxyproline in the urine.


Renal granular cell carcinoma

A renal cell carcinoma with eosinophilic cytoplasm and high nuclear grade.  Granular cells can be seen in any subtype of renal cell carcinoma, including conventional clear cell carcinoma.  This term does not represent a specific subtype of renal cell carcinoma and should no longer be used.


Malignant Peripheral Nerve Sheath Tumor of the Skin

A malignant peripheral nerve sheath tumor that arises from the skin.


Coronary Venous Dissection

A tear within the wall of a coronary vein. (ACC)


Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin


Stage IVA Vulvar Cancer AJCC v8

Stage IVA includes: (T1-T2, N3, M0); (T3, Any N, M0). T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Grade 3 Injury To Superior Vena Cava, CTCAE

Severe symptoms; limiting self care ADL; repair or revision indicated


Grade 2 Reduction in Growth Velocity, CTCAE


Grade 5 Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Neuralgia and Peripheral Nerve Pain, CTCAE


Chest Wall Chondromesenchymal Hamartoma

A rare benign lesion that arises from the rib cage and affects infants.  It results in the formation of a mass which is composed of spindle cells, cartilage, and hemorrhagic cysts.  Surgical resection is usually curative.


Acute myeloid leukemia with recurrent genetic abnormality

A group of acute myeloid leukemias characterized by recurrent genetic abnormalities, mainly balanced translocations.  (WHO, 2001)


Immunoglobulin deposition disease

A plasma cell neoplasm characterized by the deposition of immunoglobulin in tissues, resulting in impaired organ function. It includes the following entities: primary amyloidosis, heavy chain deposition disease, and light chain deposition disease.


Cerebral Artery Intra-Operative Injury, CTCAE


Disorder of eye due to diabetes mellitus

A group of disorders affecting the eye in patients with diabetes mellitus. It includes cataract, glaucoma, retinopathy, and blindness.


Testicular Cancer by AJCC v8 Stage

A term that refers to the staging of testicular cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to postpubertal germ cell tumors of the testis and malignant sex cord-stromal tumors of the testis. It does not apply to spermatocytic tumors (no AJCC staging system), nonmalignant sex cord-/gonadal -stromal tumors (no AJCC staging system), prepubertal germ cell tumors (no AJCC staging system), hematolymphoid tumors (hematologic malignancies staging system), and paratesticular neoplasms (no AJCC staging system).  (from AJCC 8th Ed.)


Grade 3 Lung Intra-Operative Injury, CTCAE


Grade 2 Mediastinum Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Pituitary Intra-Operative Injury, CTCAE


Grade 5 Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Hepatic Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Refractory Appendix Adenocarcinoma

Appendix adenocarcinoma that is resistant to treatment.


Uveitis, CTCAE

A disorder characterized by inflammation to the uvea of the eye.


Grade 1 Epstein-Barr Virus Infection Reactivation, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Decreased NCF2 Expression

An indication that the expression of NCF2 is lower than the normal range of values.


Grade 2 Upper Airway NOS Intra-Operative Injury, CTCAE


Grade 2 Bronchopulmonary Hemorrhage, CTCAE

Moderate symptoms; invasive intervention not indicated


Recurrent Fibrolamellar Carcinoma

The reemergence of fibrolamellar carcinoma after a period of remission.


Platelet Count Decreased, CTCAE

A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.


Grade 2 Eye NOS Intra-Operative Injury, CTCAE


Solar Radiation-Related Cutaneous Melanoma

Cutaneous melanoma that arises following exposure to solar radiation.


Stage II Vulva Cancer AJCC v6

Stage II includes: T2, N0, M0.  T2: Tumor confined to the vulva or vulva and perineum, more than 2cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.)


Dermal Change Lymphedema or Phlebolymphedema, CTCAE


Grade 2 Pharyngolaryngeal Pain, CTCAE

Moderate pain; limiting instrumental ADL


Silicon granuloma

A granuloma that forms in response to silicone exposure.


Genitourinary Leak Including Anastomotic Leak, CTCAE


Stage IVA Cervical Cancer AJCC v8

Stage IVA includes: T4, Any N, M0. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


Grade 3 Muscle Weakness Right-Sided, CTCAE

Limiting self care ADL


Grade 1 Neonatal Sinus Tachycardia, AE

An adverse event in a newborn characterized by brief, self-limiting, episodes of sinus tachycardia; no care changes.


Grade 1 Hyperthyroidism, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 4 Urethra Intra-Operative Injury, CTCAE


Grade 3 Bronchospasm, CTCAE

Limiting self care ADL; supplemental oxygen indicated


Grade 1 White Blood Cell Decreased, CTCAE

<LLN-3000/mm3; <LLN-3.0 x 10e9/L


Grade 2 Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Prolonged depressive adjustment reaction

Temporary but prolonged and maladaptive depressive signs and symptoms associated with a life event.


Grade 3 Anorectal Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Recurrent Paraganglioma

The reemergence of paraganglioma after a period of remission.


Microabscess

A very small, tiny abscess.


Grade 3 Photosensitivity, CTCAE

Erythema covering >30% BSA and erythema with blistering; photosensitivity; oral corticosteroid therapy indicated; pain control indicated (e.g., narcotics or NSAIDs)


Grade 1 Parotid Gland Intra-Operative Injury, CTCAE


Stridor, CTCAE

A disorder characterized by a high pitched breathing sound due to laryngeal or upper airway obstruction.


Grade 5 Salivary Duct Inflammation, CTCAE

Death


Moderately Differentiated Prostate Adenocarcinoma

An invasive prostate adenocarcinoma characterized by the presence of malignant cells exhibiting moderate differentiation.


Pleural Hemorrhage, CTCAE

A disorder characterized by bleeding from the pleural cavity.


Wound Infection, CTCAE

A disorder characterized by an infectious process involving the wound.


Very Severe Aplastic Anemia

Aplastic anemia that is characterized by bone marrow (BM) cellularity less than 25% (or less than 50% if BM is comprised of less than 30% hematopoietic cells), and two or more of the following: absolute neutrophil count of less than 200 per microliter; platelet count of less than 20,000 per microliter; or an absolute reticulocyte count of less than 20,000 per microliter.


Ventricular Arrhythmia, CTCAE 5.0

A disorder characterized by a dysrhythmia that originates in the ventricles.


Colon or Cecum or Appendix Fistula, CTCAE


Lingual Nerve Intra-Operative Injury, CTCAE


Cerebrovascular Insufficiency

A condition resulting in inadequate blood flow through the blood vessels supplying the brain, due to intrinsic disease of the vasculature.


Angiotensin converting enzyme inhibitor foetopathy

Fetal embryopathy associated with maternal angiotensis converting enzyme (ACE) inhibitor use during pregnancy that may include fetal acute renal failure, growth restriction, oligohydramnios, calvaria abnormalities, preterm birth, and pulmonary hypoplasia with respiratory distress.


Decreased Concomitant Drug Peak Blood Concentration

Decreased maximum (peak) concentration of a concomitant drug observed after its administration.


Appendix Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the appendix. The Ki-67 index is higher than 20%.


Grade 4 Scrotal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Metastatic Non-Cutaneous Melanoma

A non-cutaneous melanoma that has spread from its original site of growth to another anatomic site.


Childhood Large Cell Lymphoma

A large cell lymphoma occurring in childhood.


Refractory Esophageal Carcinoma

Esophageal carcinoma that is resistant to treatment.


Grade 3 Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Bladder Spasm, CTCAE

Intervention not indicated


Grade 5 Edema of the Head and Neck, CTCAE


Ovulation Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.


Conjunctival Carcinoma

A carcinoma that arises from the conjunctiva.


Esophageal Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Grade 5 Neonatal Hypotension, AE

A hypotensive adverse event in a newborn which results in death.


Placental aromatase deficiency

An autosomal recessive condition that results in aromatase deficiency in the placenta, causing temporary virilization of the pregnant woman and virilization of her 46,XX fetus.


Grade 4 Metabolic or Respiratory Acidosis, CTCAE


Grade 4 Renal and Urinary Disorders - Other, Specify, CTCAE


Grade 4 Peripheral Motor Neuropathy, CTCAE


Refractory Malignant Germ Cell Tumor

Malignant germ cell tumor resistant to treatment.


Grade 2 Pancreas Intra-Operative Injury, CTCAE


Refractory Neuroendocrine Neoplasm

A neuroendocrine neoplasm that does not respond to treatment.


Grade 3 Blurred Vision, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Purpura, CTCAE

A disorder characterized by hemorrhagic areas of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color.


Non-Neoplastic Breast Disorder

A non-neoplastic disorder that affects the breast. Representative examples include fibrocystic disease, gynecomastia, mastitis, and adenosis.


Sarcoma NCI Grade 2

A sarcoma with less than 15% necrosis.


High Grade Intraepithelial Neoplasia

A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as grade II (moderate dysplasia) or grade III (severe dysplasia).


Grade 4 Pharyngeal Necrosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Transient myocardial ischemia of newborn

A condition characterized by a temporary imbalance between the oxygen supply and demand of the heart muscle in the newborn.


Grade 2 Abdomen NOS Intra-Operative Injury, CTCAE


Pregnancy Loss, CTCAE

Death in utero.


Grade 2 Gastrointestinal Leak NOS, CTCAE


Grade 4 Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Laryngeal Mucositis, CTCAE

Death


Grade 3 Pharyngeal Necrosis, CTCAE

Inability to aliment adequately by GI tract; invasive intervention indicated; tube feeding or TPN indicated


Grade 2 Bronchospasm, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Grade 2 Chylous Ascites, CTCAE

Symptomatic; medical intervention indicated (e.g., fat-restricted diet); paracentesis or tube drainage indicated


Optic Nerve Disorder, CTCAE

A disorder characterized by involvement of the optic nerve (second cranial nerve).


Grade 2 Vas Deferens Stricture or Stenosis, CTCAE


Grade 1 Nail Infection, CTCAE

Localized, local intervention indicated


Refractory Adenovirus Infection

An adenovirus infection that does not respond to treatment.


Grade 2 Ureteric Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Unresectable Renal Pelvis and Ureter Urothelial Carcinoma

Renal pelvis and ureter urothelial carcinoma that is not amenable to surgical resection.


Grade 2 Diarrhea, CTCAE

Increase of 4-6 stools per day over baseline; moderate increase in ostomy output compared to baseline; limiting instrumental ADL


Grade 5 Neonatal Epileptic Seizure, AE

An adverse event in a newborn characterized by death related to electroencephalogram (EEG)-proven seizures.


Grade 4 Spermatic Cord Obstruction, CTCAE


Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Renal Colic, CTCAE

Mild pain not interfering with activity; nonprescription medication indicated


Adverse Drug Reaction to Systemic Antibiotic

A detrimental or unintended response associated with the use of a systemic antibiotic.


Grade 2 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Small Bowel Obstruction NOS, CTCAE


Grade 4 Cecum or Appendix Hemorrhage, CTCAE


Meningismus, CTCAE

A disorder characterized by neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges.


Refractory Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia that does not respond to treatment.


Grade 3 Atrioventricular Block Complete, CTCAE

Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker); new onset


Human Papillomavirus-Independent Cervical Adenocarcinoma In Situ

Cervical adenocarcinoma in situ not associated with human papillomavirus infection.


Bacteremia, CTCAE

A disorder characterized by the presence of bacteria in the blood stream.


Musculoskeletal Chest Pain due to Myositis

A condition in which there is musculoskeletal chest pain secondary to inflammation of the muscle tissue. (ACC/AHA)


Grade 2 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Myeloid Neoplasms with Germline ANKRD26 Mutation

An autosomal dominant disorder characterized by moderate thrombocytopenia and increased risk of developing myelodysplastic syndrome/acute myeloid leukemia. This disorder is characterized by germline mutations in ANKRD26, located on chromosome band 10p12.1. (WHO 2017)


Grade 5 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Ventricular Arrhythmia, CTCAE

Life-threatening consequences; hemodynamic compromise


Early Unfavorable Hodgkin Lymphoma

An early Hodgkin lymphoma with unfavorable prognosis.


Grade 3 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Stage IIB Appendix Carcinoma AJCC v7

Stage IIB includes: T4a, N0, M0. T4a: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Colon or Cecum or Appendix Necrosis, CTCAE


Childhood TdT Positive Acute Lymphoblastic Leukemia

TdT positive acute lymphoblastic leukemia that occurs during childhood.


Tendon Reflex Decreased, CTCAE

A disorder characterized by less than normal deep tendon reflexes.


Endometrioid adenocarcinoma, ciliated cell variant

An endometrioid adenocarcinoma arising from the endometrium, in which ciliated cells line the majority of the malignant glands.


Grade 2 Spermatic Cord Obstruction, CTCAE

Symptomatic; elective intervention indicated


Adult Acute Myeloblastic Leukemia

An acute myeloid leukemia occurring in adults.


Infection and inflammatory reaction due to internal orthopedic fixation device

An infectious process involving an implanted medical device and the surrounding tissues.


Nonorganic Insomnia

Insomnia as a result of an extrinsic cause.


Pulmonary Fistula, CTCAE

A disorder characterized by an abnormal communication between the lung and another organ or anatomic site.


Grade 3 Hepatic Failure, CTCAE

Asterixis; mild encephalopathy; drug-induced liver injury (DILI); limiting self care ADL


Non-Fatal Cardiopulmonary Arrest Cause Unknown, CTCAE


Grade 1 Hyperkeratosis, CTCAE

Present


Grade 5 Adult Respiratory Distress Syndrome, CTCAE

Death


Grade 1 Gastrointestinal Stoma Hemorrhage, CTCAE


Penis Infection with Unknown Absolute Neutrophil Count, CTCAE


Epstein-Barr Virus-Related Lymphoproliferative Disease with Primary Immunodeficiency

An EBV-related lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder.


Low Grade Anal Canal Intraepithelial Neoplasia

Intraepithelial neoplasia involving the anal canal.  The epithelial cells exhibit mild dysplasia (grade I intraepithelial neoplasia).


Urinary Tract Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of contents of the urinary tract.


Grade 4 Methemoglobinemia, CTCAE

Life-threatening consequences


Grade 1 Voice Changes and Dysarthria, CTCAE


Grade 1 Libido Increased, CTCAE

Present


Gallbladder Mucinous Cystic Neoplasm with Intermediate Grade Intraepithelial Neoplasia

A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of moderate atypia.


Osteosarcoma recurrent

The reemergence of osteosarcoma after a period of remission.


Grade 2 Blood Prolactin Abnormal, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 3 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Grade 1 Renal Calculi, CTCAE

Asymptomatic or mild symptoms; occasional use of nonprescription analgesics indicated


Chest wall cyst

A cystic lesion in the chest wall.


Borderline Resectable Mass

A tumor mass finding that refers to a continuum between resectable and locally advanced unresectable disease.


Stage II Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

Stage II includes: T2, N0, M0. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Antenatal Hydronephrosis

Hydronephrosis that occurs in a fetus.


Grade 4 Photosensitivity, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Infantile Apnea, AE

An adverse event in a newborn characterized by self-limiting apnea.


Stage IV Adult Diffuse Small Cleaved Cell Lymphoma

Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Malignant Proliferating Pilar Tumor

A rare malignant neoplasm that arises from the outer root sheath of the hair follicle. It usually occurs in the scalp, face and trunk. Histopathology shows cords of malignant squamous cells infiltrating into the dermis.


Grade 3 Conduction Disorder, CTCAE

Symptomatic, urgent intervention indicated


Grade 3 Scrotum Intra-Operative Injury, CTCAE


Grade 4 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IB Bone Cancer AJCC v7

Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 2 Anorgasmia, CTCAE

Inability to achieve orgasm adversely affecting relationship


Grade 3 Gallbladder Fistula, CTCAE

Invasive intervention indicated


Grade 3 Intraoperative Arterial Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 2 Laryngeal Mucositis, CTCAE

Moderate pain, analgesics indicated; altered oral intake; limiting instrumental ADL


Grade 4 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Infections and Infestations - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Hodgkin's Disease, Nodular Sclerosis, Lymphocyte Depletion


Grade 1 Kidney Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Grade 4 Night Blindness, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Platinum-Resistant Malignant Germ Cell Tumor

A malignant germ cell tumor that is resistant to platinum therapy.


Adult Unfavorable Prognosis Hodgkin Lymphoma

A Hodgkin lymphoma with unfavorable prognosis that occurs during adulthood.


Grade 3 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Ureter Intra-Operative Injury, CTCAE


Grade 1 Small Intestinal Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 5 Pulmonary Fistula, CTCAE

Death


Grade 3 Cervix Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic malignant neoplasm to conjunctiva

A malignant neoplasm that has spread to the conjunctiva from another anatomic site.


Anaplastic (Malignant) Intracranial Meningioma

An anaplastic meningioma that arises within the cranial cavity.


Grade 1 INR Increased, CTCAE

>1.2-1.5; >1-1.5 x baseline if on anticoagulation; monitoring only indicated


Hereditary factor XII deficiency disease

A rare autosomal recessive inherited bleeding disorder caused by deficiency of coagulation factor XII. It may be asymptomatic or manifest with bleeding.


Metastatic Vaginal Carcinoma

A carcinoma that arises from the vagina and has metastasized to another anatomic site.


Grade 1 Fallopian Tube Intra-Operative Injury, CTCAE


Stage IIIA Intrahepatic Bile Duct Cancer AJCC v8

Stage IIIA includes: T3, N0, M0. T3: Tumor perforating the visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


CTCAE v4 Grade 3

An adverse event that is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, e.g., getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet).


Grade 5 Gum Infection, CTCAE

Death


Grade 2 Anal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Osteoclastic Giant Cell-Rich Tumor of Bone

A benign, intermediate, or malignant bone tumor characterized by the presence of osteoclast-like giant cells. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.


Grade 2 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Endometrioid adenocarcinoma metastatic

An endometrioid adenocarcinoma that has spread from its original site of growth to another anatomic site.


Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Pulmonary Hypertension, CTCAE

Severe symptoms, associated with hypoxia, right heart failure; oxygen indicated


Grade 2 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


Recurrent Malignant Neoplasm of Multiple Primary Sites

Reemergence of a malignant neoplasm of multiple primary sites after a period of remission.


Grade 4 Anal Ulcer, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Thalassemic Osteopathy

Bone disorders that present in thalassemia patients.


Grade 5 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Breast Fibrocystic Change, Proliferative Type without Atypia

Breast fibrocystic change characterized by the presence of epithelial cell hyperplasia.  There is no evidence of epithelial atypia.


Grade 2 Personality and Behavioral Change, CTCAE


Grade 1 Retinal Tear, CTCAE

No retinal detachment and treatment not indicated


Paronychia, CTCAE

A disorder characterized by an infectious process involving the soft tissues around the nail.


Cervical Neuroendocrine Tumor G1

A well-differentiated, low grade neuroendocrine neoplasm that arises from the cervix.


Grade 4 Duodenal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Cyanosis, CTCAE

A disorder characterized by a bluish discoloration of the skin and/or mucous membranes.


Low ADAMTS13 Activity

A finding indicating that a significantly lower than expected activity for the proteinase a disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13) is detected in a sample. This finding is associated with thrombotic thrombocytopenic purpura.


Granular Cell Astrocytoma

An astrocytoma characterized by the presence of large numbers of neoplastic cells with granular, PAS-positive cytoplasm. It is associated with an aggressive clinical course, even when the histologic features suggest a lower-grade astrocytoma.


High Grade Conjunctival Squamous Intraepithelial Neoplasia

A precancerous neoplastic intraepithelial process with high-grade dysplastic features involving the conjunctival epithelium.


Grade 3 Gum Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage II includes: IIA: T1, N1, M0; IIB: T2, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Pancreatic Duct Stenosis, CTCAE

Death


Intraoperative Reproductive System Injury

Damage to the reproductive organs during a surgical procedure.


Grade 5 Fallopian Tube Hemorrhage, CTCAE


Grade 2 Hip Fracture, CTCAE

Hairline fracture; mild pain; limiting instrumental ADL; non-operative intervention indicated


Grade 5 Portal Vein Thrombosis, CTCAE

Death


Nuclear Cataract Grade 2

A stage of nuclear sclerotic cataract marked by moderate yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Grade 3 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IB Intrahepatic Bile Duct Cancer AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Solitary tumor larger than 5 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Floaters, CTCAE

Symptomatic but not limiting ADL


Retinoblastoma, undifferentiated

A retinoblastoma composed of small, undifferentiated cells. It is often associated with necrotic changes.


Pain, CTCAE

A disorder characterized by the sensation of marked discomfort, distress or agony.


Grade 3 Tinnitus, CTCAE

Severe symptoms; limiting self care ADL


Malignant tumor, small cell type

A malignant neoplasm characterized by the presence of small atypical cells.


Stage IIC Prostate Cancer AJCC v8

Stage IIC includes: (T1-2, N0, M0, PSA less than 20, Grade Group 3); (T1-2, N0, M0, PSA less than 20, Grade Group 4). T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


Grade 4 Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Neonatal Pulmonary Hemorrhage, AE

An adverse event in a newborn characterized by hemorrhagic secretion in an endotracheal (ET) tube; with relevant increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation; requiring major change in ventilatory support or transfusion.


Delusional disorder, somatic type

A subtype of delusional disorder characterized by the central delusional theme that the individual has some physical defect or medical condition.


Grade 2 Duodenal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Urinary Fistula, CTCAE

A disorder characterized by an abnormal communication between any part of the urinary system and another organ or anatomic site.


Bladder Paraganglioma

An extra-adrenal sympathetic paraganglioma arising from the urinary bladder.  Clinical signs include hypertension and hematuria.


Adverse Event Associated with Ocular and Visual Systems


Grade 2 Night Blindness, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL


Broad Ligament Serous Adenocarcinoma

A rare serous adenocarcinoma that arises from the broad ligament.


Grade 5 Menorrhagia, CTCAE

Death


Grade 2 Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Esophageal adenocarcinoma recurrent

An esophageal adenocarcinoma which has reappeared after a period of remission or after presumed treatment.


Cervical Cancer by AJCC v7 Stage

A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 7th edition.


Malignant Non-Hodgkin Lymphoma, Cleaved Cell


Vaginal Keratinizing Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the vagina and is characterized by the presence of keratin pearls. Intercellular bridges and cytoplasmic keratinization are usually present.


Cutaneous neurofibroma

A neurofibroma that grows along small branches of nerves in the dermis in patients with neurofibromatosis. It presents as a solid cutaneous tumor.


Grade 2 Gastric Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Stage IIA1 Cervical Cancer AJCC v9

Stage IIA1 includes: T2a1, N0, M0. T2a1: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 4 Neutrophil Count Decreased, CTCAE

<500/mm3; <0.5 x 10e9/L


Conjunctival Spitz Nevus

A rare nevus that arises from the conjunctiva. It is characterized by the presence of large spindle-shaped or epithelioid melanocytes.


Prostate Undifferentiated Carcinoma

An invasive prostate carcinoma characterized by the presence of undifferentiated malignant cells.


Grade 3 Fibrinogen Decreased, CTCAE

<0.5-0.25 x LLN; if abnormal, 50-<75% decrease from baseline


Tinnitus, CTCAE 5.0

A disorder characterized by noise in the ears, such as ringing, buzzing, roaring or clicking.


Actinomycotic granuloma

A granuloma that develops in response to Actinomycotic fungal infection.


Grade 2 Intraoperative Hepatobiliary Injury, CTCAE

Partial resection of injured organ/structure indicated


Grade 5 Device Related Infection, CTCAE

Death


Refractory Liposarcoma

Liposarcoma that does not respond to treatment.


Grade 5 Hepatitis Viral, CTCAE

Death


Stage IV Cervical Cancer AJCC v6 and v7

Stage IV includes: IVA: (T4, Any N, M0); IVB (Any T, Any N, MI). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M1: Distant metastasis. (AJCC 6th and 7th eds.)


Grade 1 Nails Intra-Operative Injury, CTCAE


Fall, CTCAE

A finding of sudden movement downward, usually resulting in injury.


Grade 4 Stoma GI Stricture or Stenosis, CTCAE


Grade 5 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Aspartate Aminotransferase Increased, CTCAE

>3.0-5.0 x ULN if baseline was normal; >3.0-5.0 x baseline if baseline was abnormal


Grade 2 Seizure, CTCAE

Brief generalized seizure


Grade 4 Kidney Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Pancreatic Necrosis, CTCAE

Death


Grade 3 Hepatobiliary Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Anaplastic Astroblastoma, MN1-Altered

An astroblastoma, MN1-altered, characterized by the presence of high mitotic activity, cytologic atypia, and architectural distortion.


Grade 1 Neonatal Sinus Bradycardia, AE

An adverse event in a newborn characterized by brief, self-limiting, episodes of sinus bradycardia; no care changes.


Refractory Appendix Carcinoma

Appendix carcinoma that is resistant to treatment.


Grade 3 Upper Respiratory Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Alopecia, CTCAE

A disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location.


Grade 1 Left Ventricular Diastolic Dysfunction, CTCAE


Critical illness myopathy

Acute muscle weakness and paralysis that develops in critically ill patients who have been treated with multiple drugs during their intensive care unit stay. It is associated with delayed weaning from mechanical ventilation and prolonged rehabilitation.


Grade 5 Bladder Infection, CTCAE

Death


Lugano Classification Limited Stage Adult Lymphoma AJCC v8

Limited stage adult lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Perforation due to Lead

Penetration of a lead through a systemic vein, coronary vein, or the myocardium. (ACC)


Stage IIIC Appendix Carcinoma AJCC v8

Stage IIIC includes: Any T, N2, M0. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Cranial Nerve II Neuropathy, CTCAE


Grade 3 Tumor Pain, CTCAE

Severe pain; limiting self care ADL


Trigeminal neuralgia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Grade 1 Sacral Plexus Intra-Operative Injury, CTCAE


Grade 3 Genitourinary Stoma Stricture or Stenosis, CTCAE


Grade 5 Genitourinary Stoma Prolapse, CTCAE


Portal Hypertension, CTCAE

A disorder characterized by an increase in blood pressure in the portal venous system.


Grade 2 Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Laryngeal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 2 Hyperlipidemia, CTCAE

Requiring pharmaceutical intervention


Metastatic Merkel Cell Carcinoma

A Merkel cell carcinoma that has spread from the original site of growth to another anatomic site.


Endometrial Neuroendocrine Carcinoma

A small cell or large cell neuroendocrine carcinoma arising from the endometrium.


Ampullary Flat Intraepithelial Neoplasia, High Grade

A non-polypoid, preinvasive neoplasm that arises from the ampulla of Vater.  It is characterized by the presence of high grade dysplasia.


Chronic Ocular Graft Versus Host Disease

Chronic graft versus host disease occurring in the eye.


Injury Asphyxation

Acute compression of the thoracic cavity, causing  increased intrathoracic pressure and the backflow of blood from the right atrium and superior vena cava into the brachiocephalic and jugular veins, with resulting stagnation of blood flow and subsequent localized blood-oxygen desaturation in the head and neck.


Non-Resectable Malignant Liver Neoplasm

A malignant neoplasm that affects the liver and it is not amenable to surgical resection.


Grade 3 Hypertension, CTCAE

Adult: Systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg; medical intervention indicated; more than one drug or more intensive therapy than previously used indicated; Pediatric and adolescent: Systolic and/or diastolic > 5 mmHg above the 99th percentile


Grade 1 Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Residual Tumor

Tumor cells that remain in the body following cancer treatment.


Grade 4 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Esophageal Basal Cell Hyperplasia

A reactive (non-neoplastic) hyperplastic process affecting the esophageal squamous epithelium that is caused by inflammation.  Morphologically it involves more than 15% of the thickness of the esophageal squamous epithelium.  Its association with an increase risk of developing squamous cell carcinoma remains controversial.


Grade 1 Chylous Ascites, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Enterocolitis Infectious, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated; profuse watery diarrhea with signs of hypovolemia; bloody diarrhea; fever; severe abdominal pain; hospitalization indicated


Grade 1 Blood Corticotrophin Decreased, CTCAE


Grade 3 Anal Stenosis, CTCAE

Symptomatic and severely altered GI function; non-emergent operative intervention indicated; TPN or hospitalization indicated


Grade 2 Scrotal Pain, CTCAE

Moderate pain; limiting instrumental ADL


Pathologic Stage IIIA Cutaneous Melanoma AJCC v8

Stage IIIA includes: T1a/b-T2a, N1a or N2a, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IV includes: IVA: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Diffuse Midline Glioma

A diffuse glioma that arises from the midline structures of the central nervous system. The majority of these tumors are found in the brainstem.


Unresectable Gastroesophageal Junction Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from the gastroesophageal junction and is not amenable to surgical resection.


Adult Acute Myeloid Leukemia without Maturation

An acute myeloid leukemia without maturation occurring in adults.


Gravid Uterus Adjusted Maternal Body Weight Gain

The amount of maternal body weight gained over a period of time where the weight at the end of the interval is adjusted for the gravid uterus weight. This is derived by subtracting the maternal body weight adjusted for the gravid uterus from the total maternal body weight.


Grade 2 Shingles, CTCAE

Local infection with moderate symptoms; oral intervention indicated; limiting age-appropriate instrumental ADL


Grade 2 Atrial Fibrillation, CTCAE

Non-urgent medical intervention indicated


Advanced Angiosarcoma

An angiosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Basal Cell Carcinoma

Basal cell carcinoma that is not amenable to surgical resection.


anaplastic carcinoma of urethra

An undifferentiated carcinoma arising from the urethra.


Grade 4 Testicular Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Conjunctival Blue Nevus

A benign melanocytic neoplasm that arises from the conjunctiva. It is characterized by the presence of dendritic and spindle-shaped melanocytes in the subepithelial connective tissue. It presents as a dark brown or black, slightly elevated conjunctival lesion.


Intraoperative Endocrine Injury

Damage to an endocrine gland during a surgical procedure.


Bilateral anophthalmos of eyes

A rare congenital abnormality characterized by the complete absence of ocular tissue in both orbits.


Salivary Gland Fistula, CTCAE

A disorder characterized by an abnormal communication between a salivary gland and another organ or anatomic site.


acute megakaryoblastic leukemia in relapse

The reemergence of acute megakaryoblastic leukemia after a period of remission.


Grade 4 Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage III Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein. T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis.  For intrahepatic cholangiocarcinoma: Stage III includes: T3, N0, M0. T3: Tumor perforating the visceral peritoneum or involving the local extra hepatic structures by direct invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 7th Ed.)


Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Esophageal Pain, CTCAE

Mild pain


Grade 4 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Esophagitis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Localized Lymphoma

A lymphoma that is confined to a specific site without evidence of spread to other anatomic sites.


malignant enteroglucagonoma

A glucagon-producing malignant endocrine neoplasm. It displays vascular invasion and metastasizes to other anatomic sites.


Grade 4 Superior Vena Cava Syndrome, CTCAE

Life-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery)


Grade 3 Hoarseness, CTCAE

Severe voice changes including predominantly whispered speech


Stage III Renal Pelvis and Ureter Cancer AJCC v7

Stage III includes: T3, N0, M0. T3: For renal pelvis only: tumor invades beyond muscularis into peripelvic fat or the renal parenchyma.  For ureter only: tumor invades beyond muscularis into periureteric fat.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Anal cancer recurrent

The reemergence of anal carcinoma after a period of remission.


Cytomegalovirus Infection Reactivation, CTCAE

A disorder characterized by the reactivation of cytomegalovirus (CMV).


Grade 4 Middle Ear Intra-Operative Injury, CTCAE


Grade 2 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Pneumonitis, CTCAE

Death


Grade 3 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage III Hepatocellular Carcinoma AJCC v8

Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0). T3: Multiple tumors, at least one of which is larger than 5 cm. T4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Thoracic Meningocele

A congenital abnormality in the thoracic region of the spine in which the meninges protrude through a defect in the spinal column.


Grade 3 Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Oral Pain, CTCAE

Mild pain


Refractory Endometrial Clear Cell Adenocarcinoma

Endometrial clear cell adenocarcinoma that is resistant to treatment.


Grade 3 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Growth Hormone Abnormal, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Reflux

An abnormal backward flow of a body fluid.


Ileal Hemorrhage, CTCAE

A disorder characterized by bleeding from the ileal wall.


Grade 2 Cecal Infection, CTCAE

Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Metastatic Urethral Carcinoma

Urethral carcinoma that has spread to another anatomical site.


Mediastinum Intra-Operative Injury, CTCAE


FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


Mucositis Oral, CTCAE

A disorder characterized by ulceration or inflammation of the oral mucosal.


Cataract, CTCAE 5.0

A disorder characterized by partial or complete opacity of the crystalline lens of one or both eyes. This results in a decrease in visual acuity and eventual blindness if untreated.


Beta-2-Microglobulin Greater than 3 g/mL

A laboratory test result indicating that beta-2-microglobulin is present in a sample at concentrations exceeding 3 g/mL.


Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia

Acute myeloid leukemias arising as a result of the mutagenic effect of therapeutic agents targeting DNA-topoisomerase II. The vast majority of patients present without a preceding myelodysplastic phase. The acute myeloid leukemias are usually of the monoblastic or myelomonocytic type. Clonal cytogenetic abnormalities are frequently present and usually involve chromosome 11q23 (MLL gene).


Grade 5 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Neonatal Fever, AE

An adverse event in a newborn characterized by elevation of body temperature above normal due to the production of more heat than the body is able to dissipate.


Insomnia, CTCAE 5.0

A disorder characterized by difficulty in falling asleep and/or remaining asleep.


Grade 5 Neonatal Bradyarrhythmia, AE

A bradyarrhythmia adverse event in a newborn which results in death.


Grade 4 Cranial Nerve IV Intra-Operative Injury, CTCAE


Refractory Mucosal Melanoma

Mucosal melanoma that is resistant to treatment.


Glucokinase-Associated Hyperinsulinism

Hyperinsulinism due to activating mutation(s) in the gene GCK, encoding glucokinase.


Grade 4 Neonatal Pneumothorax, AE

A pneumothorax adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise (e.g. tension pneumothorax); urgent major care change required.


Childhood Grade I Meningioma

A grade I meningioma that occurs during childhood.


Grade 4 Rectal Ulcer, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 1 Accessory Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Pelvic Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the pelvis.


Adverse Event Associated with Sexual and Reproductive Function


Serum Bicarbonate Decreased

A laboratory test result which indicates decreased levels of bicarbonate in the serum.


Grade 1 Blood Gonadotrophin Abnormal, CTCAE


Serum Glutamic Oxaloacetic Transaminase, CTCAE


Grade 4 Cervicitis Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Associated with the Teeth, CTCAE


Grade 3 Duodenal Perforation, CTCAE

Invasive intervention indicated


Grade 3 Serum Amylase Increased, CTCAE

>2.0-5.0 x ULN with signs or symptoms; >5.0 x ULN and asymptomatic


Grade 2 Bloating, CTCAE

Symptomatic, decreased oral intake; change in bowel function


Grade 3 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Larynx Intra-Operative Injury, CTCAE


Stage IIIA Prostate Cancer AJCC v8

Stage IIIA includes: T1-2, N0, M0, PSA 20 or more, Grade Group 1-4; T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


Grade 2 Nystagmus, CTCAE

Moderate symptoms; limiting instrumental ADL


FNCLCC Sarcoma Grade 1

A sarcoma with a total score of 2 or 3 according to the FNCLCC guidelines.


Refluxing Megaureter

A megaureter that demonstrates retrograde urine flow without ureteral obstruction.


Grade 5 Photosensitivity, CTCAE

Death


Grade 3 Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Prolapse of Intestinal Stoma, CTCAE

Recurrent after manual reduction; local irritation or stool leakage; difficulty to fit appliance; limiting instrumental ADL


Grade 2 Periorbital Infection, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Grade 4 Small Bowel Obstruction NOS, CTCAE


Grade 3 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Prolonged QTc Interval, CTCAE

An adverse event characterized by an abnormally long interval between the start of the Q wave and the end of the T wave in the heart's electrical cycle, corrected for heart rate.


Grade 3 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


Grade 1 Neonatal Pneumothorax, AE

An adverse event in a newborn characterized by radiological evidence of pneumothorax; no clinical signs; no care change required.


Grade 5 Joint Infection, CTCAE

Death


transvestism

A disorder characterized by recurrent sexual urges, fantasies, or behaviors in a heterosexual male involving cross-dressing.


Grade 4 Death Neonatal, CTCAE

Neonatal loss of life


Grade 3 Adult Respiratory Distress Syndrome, CTCAE

Present with radiologic findings; intubation not indicated


adenocarcinoma of gallbladder with squamous metaplasia

An infiltrating adenocarcinoma of the gallbladder characterized by the presence of metaplastic changes of the malignant glandular cells to squamous cells.


Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for Hodgkin lymphomas based on the Ann Arbor classification criteria.


Complicated malaria

Acute malaria with signs of organ dysfunction, severe anemia (hemoglobin less than 5 g/dL or hematocrit less than 15%) and/or hyperparasitemia (greater than 5% of red blood cells infected).


Papillary transitional cell carcinoma, non-invasive

A transitional cell carcinoma characterized by a papillary growth pattern and lack of stromal invasion.


Borderline Resectable Malignant Neoplasm

A term that applies to a malignant neoplasm and refers to a continuum between resectable and locally advanced unresectable disease.


Grade 3 Encephalomyelitis Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


High Grade Prostatic Intraepithelial Neoplasia, Inverted Variant

High grade prostatic intraepithelial neoplasia characterized by the presence of secretory cells with their nuclei polarized towards the lumen of the glands.


Grade 3 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gallbladder Intra-Operative Injury, CTCAE


Non-Neoplastic Conjunctival Disorder

A non-neoplastic disorder that affects the conjunctiva.


Unresectable Bladder Carcinoma

Bladder carcinoma that is not amenable to surgical resection.


Stage IV Prostate Cancer AJCC v7

Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


Grade 3 Psychiatric Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; limiting self care ADL


Stage I Adult Diffuse Small Cleaved Cell Lymphoma

Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Ileal Fistula, CTCAE

A disorder characterized by an abnormal communication between the ileum and another organ or anatomic site.


Sinus Disorder, CTCAE

A disorder characterized by involvement of the paranasal sinuses.


Diffuse Low Grade Glioma, BRAF p.V600E-Mutant

Diffuse low-grade glioma characterized by the presence of BRAF gene mutations encoding a p.V600E substitution mutation.


Grade 5 Colon or Cecum or Appendix Fistula, CTCAE


Pathologic Stage IIIB Cutaneous Melanoma AJCC v8

Stage IIIB includes: (T0, N1b, N1c, M0); (T1a/b-T2a, N1b/c or N2b, M0); (T2b/T3a, N1a-N2b, M0). T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration.  T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 3 Lung Thoracic Nerve Intra-Operative Injury, CTCAE


Recurrent Brain Neoplasm

The reemergence of a brain neoplasm after a period of remission.


A myelodysplastic/myeloproliferative neoplasm that is resistant to treatment.


Grade 2 Productive Cough, CTCAE

Moderate sputum production; limiting instrumental ADL


Postoperative Spindle Cell Nodule of the Vagina

A rare, benign, non-neoplastic reactive lesion that develops in the vagina at the site of a prior operative procedure. It is composed of spindle cells, small blood vessels, and chronic inflammation.


Chemical Exposure

Contact with a chemical substance through touch, inhalation, or ingestion.


Radiation-Induced Cancer

A malignant neoplasm arising in a site exposed to radiation therapy.


Carbon Monoxide Diffusion Capacity, CTCAE


Grade 1 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Vulvar Blue Nevus

A benign nevus that arises from the vulva and is characterized by the presence of heavily pigmented dendritic melanocytes exclusively in the dermis.


Grade 2 Pelvis Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Weight Change

An increase or decrease in the weight of an individual.


Non-Malignant Neoplasm

A category that includes benign neoplasms and neoplasms with uncertain malignant potential. The latter are characterized by clinicopathological features that are not benign, including some degree of mild or mild/moderate atypia/dysplasia, but lack overt malignant morphologic characteristics and there is no evidence of metastasis at the time of diagnosis.


Edema Face, CTCAE

A disorder characterized by swelling due to excessive fluid accumulation in facial tissues.


Grade 2 Rash Acneiform, CTCAE

Papules and/or pustules covering 10-30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL; papules and/or pustules covering > 30% BSA with or without mild symptoms


Gonadal Thrombosis

Formation of a blood clot (thrombus) in the lumen of the vein that carries blood away from the testis or ovary.


Grade 2 Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Endocrine Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 4 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Gastric carcinoma stage IV without metastases

T4,N2,MO (from PDQ)


Grade 4 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Anorexia, CTCAE

A disorder characterized by a loss of appetite.


Ovarian Mass

An abnormal growth in the ovary.


Therapy-Related Toxicity

The finding of bodily harm due to the poisonous effects associated with the action or administration of therapeutic agents.


Grade 5 External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Soft Tissue Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Myelitis, CTCAE

A disorder characterized by inflammation involving the spinal cord. Symptoms include weakness, paresthesia, sensory loss, marked discomfort and incontinence.


Stage IIIB Testicular Cancer AJCC v8

Stage IIIB includes: (Any pT/TX, N1-3, M0, S2); (Any pT/TX, Any N, M1a, S2). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. S2: LDH 1.5-10 x N or hCG (mlU/mL) 5,000-50,000 or AFP (ng/mL) 1,000-10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Grade 2 Esophageal Obstruction, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL