Glucagonoma, malignant

A glucagon-producing neuroendocrine tumor arising from the alpha cells of the pancreas.  It may be associated with necrolytic erythema migrans, diarrhea, diabetes, glossitis, weight loss, malabsorption, and anemia.  It displays vascular invasion and metastasizes to other anatomic sites.


Benign Osteoclastic Giant Cell-Rich Tumor of Bone

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

A giant cell tumor that arises from the bone and is characterized by the absence of local aggression and lack of metastatic potential.


Neonatal rickets

Rickets that usually affects premature infants. Factors that contribute to the development of neonatal rickets include calcium, phosphorus, or calciferol deficiency. It manifests with spontaneous fractures, respiratory distress, and growth developmental delays.


Unresectable Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma that is not amenable to surgical resection.


Grade 2 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon


Grade 1 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


Recurrent Plasma Cell Neoplasm

The reemergence of a plasma cell neoplasm after a period of remission.


Prostate Paraganglioma

A paraganglioma that affects the prostate gland.


Anxiety, CTCAE 5.0

A disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.


Adenoma of the Retinal Pigment Epithelium

A benign neoplasm that arises from the retinal pigment epithelium. It consists of cords and tubules of variably pigmented proliferating retinal pigment epithelium cells, separated by fibrous stroma. Malignant transformation is rare. (WHO 2018)


Neonatal Herpes Simplex Infection

Infection in the first month of life caused by the Herpes simplex virus.


Grade 2 Esophageal Infection, CTCAE

Local intervention indicated (e.g., oral antibiotic, antifungal, antiviral)


Grade 3 Other Allergy and Immunology, CTCAE


Grade 2 Movements Involuntary, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 4 Pelvis NOS Intra-Operative Injury, CTCAE


Low Grade Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Grade 1 Nail Ridging, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Neuroendocrine carcinoma of the bladder

A malignant, high grade neuroendocrine neoplasm that arises from the bladder. This category includes small cell and large cell neuroendocrine carcinoma.


Grade 3 Urostomy Obstruction, CTCAE

Altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); elective operative intervention indicated


Grade 1 Urinary Retention, CTCAE

Urinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual


Grade 1 Upper Extremity Vein Intra-Operative Injury, CTCAE


Drug Resistant Epilepsy

Epilepsy that is refractory to treatment.


Grade 1 Bronchopulmonary Dysplasia, AE

An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND breathing room air at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; breathing room air by 56 days postnatal age in infants born greater than 32 weeks' gestation; breathing room air at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


Stage IIIC Esophageal Adenocarcinoma AJCC v7

Stage IIIC includes: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent WHO Grade 3 Glioma

The reemergence of a WHO grade III glioma after a period of remission.


Ann Arbor Stage II Subdiaphragmatic Nodular Lymphocyte Predominant Hodgkin Lymphoma


Advanced Adenoid Cystic Carcinoma

Adenoid cystic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 5 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Lacrimal Drainage System Lymphoepithelial Carcinoma

A rare nonkeratinizing squamous cell carcinoma that arises from the lacrimal sac or nasolacrimal duct. It is characterized by the presence of large cells with vesicular nuclei and prominent nucleoli, a syncytial growth pattern, and a lymphoplasmacytic infiltrate.


Grade 3 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


Thrombosis of abdominal aorta

Formation of blood clot in the lumen of the abdominal aorta. It may lead to severe abdominal pain and ischemic necrosis of the intestine.


Grade 2 Breast Infection, CTCAE

Local infection with moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage IIIA Cervical Cancer FIGO 2018

Cervical carcinoma that involves the lower third of the vagina, with no extension to the pelvic wall. (FIGO 2018)


Facial Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the facial nerve (seventh cranial nerve).


Grade 5 Bronchopulmonary Dysplasia, AE

A bronchopulmonary dysplasia adverse event in a newborn which results in death.


Acquired factor IX deficiency disease

An acquired coagulation disorder characterized by the partial or complete absence of factor IX activity in the blood.


Grade 3 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Life Threatening Adverse Event

An adverse event that has life-threatening consequences; for which urgent intervention is indicated; that puts the patient at risk of death at the time of the event if immediate intervention is not undertaken.


Refractory Fallopian Tube Adenocarcinoma

Fallopian tube adenocarcinoma that is resistant to treatment.


Burn, CTCAE

A finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment.


Grade 3 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Pancreatic Duct Intra-Operative Injury, CTCAE


Grade 4 Carbon Monoxide Diffusion Capacity, CTCAE


Recurrent Childhood Fibrillary Astrocytoma

The reemergence of fibrillary astrocytoma in childhood after a period of remission.


Recurrent Pineal Parenchymal Cell Neoplasm

The reemergence of pineal parenchymal cell neoplasm after a period of remission.


Vagus Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the vagus nerve (tenth cranial nerve).


Grade 3 Social Circumstances - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Gallbladder Pain, CTCAE

Mild pain


Ureteric fistula

An abnormal communication between the ureter and another organ or anatomic site.


Grade 1 Anus Intra-Operative Injury, CTCAE


Grade 4 Stridor, CTCAE

Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Grade 2 Hepatitis B Reactivation, CTCAE

Moderate symptoms; medical intervention indicated


Grade 1 Shingles, CTCAE

Localized, local intervention indicated


Cardiac Enzyme Elevation

An increase from the normal levels of cardiac enzymes measurement.


Grade 2 Meninges Intra-Operative Injury, CTCAE


Broad Ligament Serous Cystadenofibroma

A rare serous cystadenofibroma arising from the broad ligament.


Grade 2 Colonic Obstruction, CTCAE

Symptomatic; altered GI function


Grade 2 Amnesia, CTCAE

Moderate; short term memory loss; limiting instrumental ADL


FNCLCC Sarcoma Grade 3

A sarcoma with a total score of 6 or higher according to the FNCLCC guidelines.


Grade 3 Arterial Injury, CTCAE

Severe symptoms; limiting self care ADL; repair or revision indicated


Grade 3 Esophageal Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated; limiting self care ADL


Male Reproductive System Precancerous Condition

A premalignant pathologic process arising from an organ of the male reproductive system.  It is characterized by cellular atypia and/or dysplasia but does not show morphologic evidence of stromal invasion at the time of diagnosis.  Representative examples include prostatic intraepithelial neoplasia, giant condyloma acuminatum of the penis, and penile intraepithelial neoplasia.


Grade 1 Dermatitis Radiation, CTCAE

Faint erythema or dry desquamation


Grade 1 Jejunal Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Metastatic Bone Sarcoma

Bone sarcoma that has spread from the original site of growth to another anatomic site.


Hepatic Failure, CTCAE

A disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, alkaline phosphatase, aminotransferase, and/or prolongation of prothrombin time (INR.) Drug-induced liever injury (DILI) as defined by Hy's Law.


BAP1-Inactivated Skin Melanocytic Neoplasm

A group of cutaneous melanocytic neoplasms that includes the combined BAP1-inactivated nevus and the BAP1-inactivated melanocytoma.


Hyperplasia of Brunner glands of duodenum

A rare hyperplastic lesion of Brunner's gland in the duodenum. Although it is usually asymptomatic and discovered incidentally during upper gastrointestinal endoscopy, it may cause hemorrhage.


Grade 1 Testis Intra-Operative Injury, CTCAE


Grade 2 Pleural Effusion, CTCAE

Symptomatic; intervention indicated (e.g., diuretics or therapeutic thoracentesis)


Stage IVA Oral Cavity Verrucous Carcinoma


B-Cell Proliferation of Uncertain Malignant Potential

A B-cell lymphoproliferative disorder with uncertain malignant potential. The representative example of this category is lymphomatoid granulomatosis.


Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Vulvar Carcinoma

Vulvar carcinoma that does not respond to treatment.


Grade 3 Cataract, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Premature Delivery, CTCAE

A disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation.


Grade 3 Sleep Apnea, CTCAE

Oxygen desaturation; associated with pulmonary hypertension; medical intervention indicated; limiting self care ADL


Grade 1 Bronchopulmonary Hemorrhage NOS, CTCAE


Grade 5 Lymph Leakage, CTCAE

Death


Grade 2 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 3 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Appendicitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Foreign-Body Reaction

An inflammatory lesion comprised of epithelioid histiocytes and chronic inflammation that is caused by the presence of extraneous material.


Non-Neoplastic Musculoskeletal Disorder

A non-neoplastic disorder that affects muscles and bones.


Grade 3 Pharynx Obstruction and Stenosis, CTCAE


Grade 2 Blood Bilirubin Increased, CTCAE

>1.5-3.0 x ULN if baseline was normal; >1.5-3.0 x baseline if baseline was abnormal


lymphomatoid papulosis, type C

A variant of lymphomatoid papulosis characterized clinically by regressing skin papules, and morphologically by features resembling anaplastic large cell lymphoma.


Ovarian or testicular dysfunction associated with high levels of gonadotropins, that is present at birth.


Recurrent Ampulla of Vater Adenocarcinoma

The reemergence of ampulla of Vater adenocarcinoma after a period of remission.


Maternal Weight Gain in Pregnancy

The last recorded maternal weight prior to birth minus the last recorded weight immediately prior to pregnancy. (reVITALize)


Congenital Cystic Hygroma

A congenital lymphatic malformation usually arising from the neck and characterized by cystic dilation of the lymphatic vessels.


Adenocarcinoma endometrial metastatic

An adenocarcinoma which originated in the endometrium and has spread to another anatomic site.


Refractory Acute Myeloid Leukemia Not Otherwise Specified

Acute myeloid leukemia not otherwise specified that does not respond to treatment.


Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder

The reemergence of monomorphic post-transplant lymphoproliferative disorder after a period of remission.


Grade 5 Splenic Infection, CTCAE

Death


An exceedingly rare adenocarcinoma that arises from the endometrium and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Grade 1 Flatulence, CTCAE

Mild symptoms; intervention not indicated


Female urinary-genital tract fistula

An abnormal connection between the urinary system and the genitals in a female.


Stage IB Gastric Carcinoma

Stage IB includes: (T2, N0, M0); (T1, N1, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Appendicitis Perforated, CTCAE

A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.


Grade 3 Prolapse of Intestinal Stoma, CTCAE

Severe symptoms; elective operative intervention indicated; limiting self care ADL


Grade 3 Lymph Node Pain, CTCAE

Severe pain; limiting self care ADL


Primary Malignant Pelvic Neoplasm

A malignant neoplasm that arises from the organs and structures of the pelvis.


Grade 2 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Severe Cardiac Valve Regurgitation

Evidence of severe retrograde blood flow through the valve(s) of the heart. (ACC)


FIGO Grade 1 Endometrial Mucinous Adenocarcinoma

A primary mucinous adenocarcinoma of the endometrium that contains equal to or less than 5% non-squamous solid areas.


Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Gallbladder Intra-Operative Injury, CTCAE


Grade 5 Middle Ear Inflammation, CTCAE

Death


Grade 1 Breast Atrophy, CTCAE

Minimal asymmetry; minimal atrophy


Mixed Cellularity Classic Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for mixed cellularity classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Grade 4 Gallbladder Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Bladder Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Stage III Urethral Cancer AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0). T1: For male penile urethra and female urethra: Tumor invades subepithelial connective tissue. For prostatic urethra: Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. T3: For male penile urethra and female urethra: Tumor invades any of the following: corpus cavernosum, anterior vagina. For prostatic urethra: Tumor invades the periprostatic fat. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IIIA Appendix Carcinoma AJCC v8

Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


clear cell adenocarcinoma of gallbladder

A rare morphologic variant of gallbladder adenocarcinoma composed of malignant glandular epithelium with a predominance of glycogen rich clear cells.  The cells display hyperchromic nuclei and well-defined cytoplasmic borders.


Nervous System Disorders - Other, Specify, CTCAE


Chronic inflammation

An inflammatory process characterized by the presence of lymphocytes and plasma cells and the absence of polymorphonuclear neutrophils.


Fetal Neurodevelopmental Disorder

A fetal affliction that has a neurological basis and manifests as a developmental disability.


Grade 3 Colonic Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Recurrent Anaplastic Astrocytoma

The reemergence of anaplastic astrocytoma after a period of remission.


Stage IIIB Hepatocellular Carcinoma AJCC v8

Stage IIIB includes: T4, N0, M0. T4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


Grade 5 Neonatal Respiratory Insufficiency, AE

A respiratory insufficiency adverse event in a newborn which results in death.


Miserable Pain

A sensation of discomfort or distress that renders an individual unable to find any happiness.


Grade 3 Bullous Dermatitis, CTCAE

Blisters covering >30% BSA; limiting self care ADL


Stage I Vulvar Cancer

Stage I includes: T1, N0, M0. T1: Invasive vulvar cancer confined to the vulva or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 5 Vagus Nerve Disorder, CTCAE

Death


T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta

An uncommon variant of T-cell large granular lymphocyte leukemia expressing the gamma-delta T-cell receptor. Approximately 60% of these cases are CD8-positive and the remainder are CD4/CD8-negative.


Unresectable Low Grade Glioma

Low grade glioma that is not amenable to surgical removal.


trauma to the abdomen

Trauma to the abdomen.


Stage I Bone Cancer AJCC v7

Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Gastrointestinal Perforation, CTCAE

An adverse event marked by rupture in the wall of a structure of the gastrointestinal system.


Stage III Bone Cancer AJCC v8

Stage III includes: T3, N0, M0, G2 or G3. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Grade 2 Colon Intra-Operative Injury, CTCAE


Radiating Chest Pain Along Right Middle Sternal Border

The location of the radiating chest pain is along the right middle sternal border.


Pancreatic Enzymes Decreased

A laboratory test result which indicates decreased levels of pancreatic enzymes in a biologic specimen.


Grade 1 Upper Extremity Intra-Operative Injury, CTCAE


Grade 1 Leukoencephalopathy Radiographic Findings, CTCAE


Grade 3 Muscular and Skeletal Hypoplasia, CTCAE


Metastatic malignant neoplasm to retina

A malignant neoplasm that has spread to the retina from another anatomic site.


Elevated DKK1

A finding indicating elevated concentrations of DKK1 in a sample.


Stage IVB Uterine Corpus Cancer AJCC v7

Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone.  It excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa). This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Stage IB3 Cervical Cancer FIGO 2018

Invasive cervical carcinoma equal or more than 4 cm in greatest dimension. (FIGO 2018)


Cutaneous Mature B-Cell Neoplasm

A B-cell neoplasm that arises from the skin.


Grade 3 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Prostate Melanoma

An exceptionally rare melanoma arising from the prostate gland.


Grade 3 Retinal Vascular Disorder, CTCAE

Retinal vascular disorder with neovascularization


Deep Lipoma

A benign well-circumscribed tumor, composed of mature adipocytes, that arises within deep soft tissues.


Craniofacial Fibrous Dysplasia

Fibrous dysplasia affecting the craniofacial bones.


Grade 5 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cardiac granuloma

A granuloma located in the myocardium.


Grade 3 Pancreatic Duct Intra-Operative Injury, CTCAE


Grade 2 Proctitis, CTCAE

Symptomatic (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental ADL


Persistent Pulmonary Hypertension of the Newborn, AE

An adverse event in a newborn characterized by elevated pulmonary vascular pressure in a neonate.


Grade 5 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Cecal Infection, CTCAE

Death


Neonatal Spell

Cardiorespiratory events that are characterized by variable combinations of cessation of breathing, decrease in blood oxygen saturation, and decreased heart rate.


Stage IIA Esophagus Carcinoma

Stage IIA includes: For squamous cell carcinoma: (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X).  For adenocarcinoma: (T2, N0, M0, G3).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Grade 4 Ovary Intra-Operative Injury, CTCAE


Mucositis and Stomatitis by Functional and Symptomatic Classification, CTCAE


Leukopenia neonatal

Leukopenia that occurs in the neonatal period.


Acute lymphoblastic leukemia recurrent

The reemergence of acute lymphoblastic leukemia after a period of remission.


Pancreatic intraepithelial neoplasia

A pre-cancerous, non-invasive pancreatic epithelial neoplasm that arises from and is confined to the pancreatic ducts.  It is a papillary or flat neoplasm that usually measures less than 5 mm in diameter.


Esophageal Cancer by AJCC v8 Stage

A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 8th edition.


Stage IIIB Merkel Cell Carcinoma AJCC v7

Stage IIIB includes: Any T, N1b/N2, M0.  N1b: Macrometastasis in regional lymph nodes.  N2: In transit metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Recurrent Myeloproliferative Neoplasm

The reemergence of a myeloproliferative neoplasm after a period of remission.


Burn of axilla

A traumatic injury to the axilla resulting from exposure to caustic chemicals, extreme heat, extreme cold, or excessive radiation.


Grade 3 Hematosalpinx, CTCAE

Transfusion indicated; invasive intervention indicated


Bladder Infection, CTCAE

A disorder characterized by an infectious process involving the bladder.


Adverse Event Attributed to Disease

An indication that an adverse event is causally related to the natural history of disease.


Grade 2 Mucositis Oral, CTCAE

Moderate pain or ulcer that does not interfere with oral intake; modified diet indicated


Grade 5 Arteritis Infective, CTCAE

Death


Acute Rejection

Rejection of a transplanted organ that usually occurs after the first week of the transplantation.  The risk of acute rejection is highest in the first three months following transplantation.  Morphologically, there is an inflammatory infiltrate composed of lymphocytes and neutrophils and vascular damage in the rejected tissue.


Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Pancreatic Endocrine Glucose Intolerance, CTCAE


Sexual Aversion Disorder

A disorder characterized by recurrent or persistent extreme aversion to, and avoidance of, all genital contact with a sexual partner. The aversion to sexual contact is not attributable to another psychiatric disorder.


Gallbladder Tubular Carcinoid

A neuroendocrine tumor that arises from the gallbladder.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


Grade 2 Breast Volume and Hypoplasia, CTCAE


Grade 3 Intraoperative Gastrointestinal Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 2 Small Intestinal Mucositis, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Benign Thymoma

A thymoma that is completely surrounded by a capsule, without evidence of capsular invasion, infiltration of the surrounding tissues, and metastases.


Cutaneous Melanoma by AJCC v8 Clinical Stage

A term that refers to the clinical staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


Grade 4 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Proctitis, CTCAE

Severe symptoms; fecal urgency or stool incontinence; limiting self care ADL


Grade 3 Vaginal Perforation, CTCAE

Invasive intervention indicated


Grade 2 Lymph Leakage, CTCAE

Symptomatic; medical intervention indicated


Grade 4 Nephrotic Syndrome, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage IA Cervical Cancer FIGO 2009

Cervical carcinoma measuring equal or less than 5 mm in depth and equal or less than 7 mm in width. (FIGO 2009)


Primary Valvular Disorder

Heart disease that is primarily due to a valvular defect or abnormality. Valve disease that is felt to be significant but does not fulfill the definition for primary valvular heat disease is considered contributory valvular heart disease.


Grade 3 Genitourinary Stoma Obstruction, CTCAE


Merkel Cell Carcinoma by AJCC v7 Stage

A term that refers to the staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v7 classification system.


Complication of transplanted organ, NOS

A disease or disorder that is associated with a transplanted organ.


Grade 2 Hallucinations, CTCAE

Moderate hallucinations


Grade 2 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Serum Hypertriglyceridemia, CTCAE


Grade 5 Nervous System Disorders - Other, Specify, CTCAE

Death


Opportunistic Infection Associated with Grade 2 or Greater Lymphopenia, CTCAE


Grade 2 Pain of Skin, CTCAE

Moderate pain; limiting instrumental ADL


Pelvic Undifferentiated High Grade Pleomorphic Sarcoma

Undifferentiated high grade pleomorphic sarcoma  involving the bones of the pelvis.


Chronic Orthostatic Intolerance

A condition in which there is orthostatic intolerance lasting for at least three months with associated functional impairment. (ACC/AHA)


Grade 3 Scrotal Pain, CTCAE

Severe pain; limiting self care ADL


Recurrent Malignant Urinary System Neoplasm

Reemergence of a malignant urinary system neoplasm after a period of remission.


Grade 4 Hyperphosphatemia, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., dialysis)


Grade 5 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Grade 1 Thyroid Stimulating Hormone Increased, CTCAE

TSH increased and no intervention initiated


Iron deficiency without anemia

Subnormal concentrations of iron resulting from low iron intake, inefficient iron absorption in the gastrointestinal tract, or increased iron loss; occurring in the absence of anemia.


Stage I Esophageal Adenocarcinoma AJCC v7

Stage I includes: IA (T1, N0, M0, G1-2, X); IB (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Grade 3 Alcohol Intolerance, CTCAE

Severe symptoms; limiting self care ADL


Grade 3 Acidosis, CTCAE

pH <7.3


Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8

Stage IIIB includes: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Advanced gastric carcinoma

Gastric carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Refractory Dedifferentiated Liposarcoma

Dedifferentiated liposarcoma that does not respond to treatment.


Flushing, CTCAE 5.0

A disorder characterized by episodic reddening of the skin, especially face, neck, or chest.


Cellulitis of pharynx

Cellulitis of the pharynx.


Grade 2 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


High grade cervical glandular intraepithelial neoplasia

Cervical glandular intraepithelial neoplasia characterized by the presence of severe dysplastic changes.


Grade 3 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Severe Adverse Event

An adverse event experience that requires intensive therapeutic intervention and interrupts usual daily activities.


Extrahepatic bile duct cancer stage III

Stage III includes: T4, Any N, M0.  T4: Tumor invades any of the following main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: Distant metastasis. (AJCC 6th ed.)


Aplastic bone marrow

Depletion of stem cells in the bone marrow that results in the lack of production of hematopoietic cells.


Grade 2 Pleura Intra-Operative Injury, CTCAE


Cerebellar Paraganglioma

An extra-adrenal paraganglioma arising from the cerebellum.


Grade 4 Oral Intra-Operative Injury, CTCAE


Lymphoma by Lukes-Collins Classification (Antiquated)


High Grade Prostatic Intraepithelial Neoplasia

Prostatic intraepithelial neoplasia characterized by the presence of morphologically malignant cells lining the acini and ducts.  The malignant cells are enlarged, contain prominent nucleoli, and have increased nuclear/cytoplasmic ratio.  The malignant cells may grow within the ducts and acini in four architectural patterns: flat, tufting, micropapillary, and cribriform.  The presence of high grade prostatic intraepithelial neoplasia in needle biopsy is a risk factor for the subsequent detection of carcinoma on repeat biopsy.


Grade 5 Intraoperative Renal Injury, CTCAE

Death


Grade 5 Pyramidal Tract Syndrome, CTCAE

Death


Grade 2 Feminization Acquired, CTCAE

Moderate symptoms; medical intervention indicated


Stage IV Ureter Cancer AJCC v7

Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  N1: Distant metastasis.  (AJCC 7th ed.)


Grade 2 Urinary Incontinence, CTCAE

Spontaneous; pads indicated; limiting instrumental ADL


Grade 5 Duodenal Hemorrhage, CTCAE

Death


Liver and Intrahepatic Bile Duct Malignant Non-Epithelial Neoplasm

A malignant non-epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts.  Representative examples include lymphoma, angiosarcoma, and undifferentiated (embryonal) sarcoma.


Grade 4 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Mixed Phenotype Acute Leukemia, B/T/Myeloid, Not Otherwise Specified

A very rare mixed phenotype acute leukemia, not otherwise specified in which the blasts show evidence of trilineage (B-cell, T-cell, and myeloid lineage) assignment. (WHO 2017)


Grade 3 Ileal Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


High Grade Bladder Urothelial Carcinoma

Bladder urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


Grade 3 Hypoxia, CTCAE

Decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg)


EBV-Related Post-Transplant Lymphoproliferative Disorder


Stage I Lentigo Maligna Melanoma AJCC v7

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 3 Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


Lacrimal Drainage System Mucoepidermoid Carcinoma

A carcinoma that arises from the lacrimal sac. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Paratesticular tumor

A benign or malignant neoplasm that affects the paratesticular structures.


Grade 4 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 1 Pulmonary Hypertension, CTCAE

Minimal dyspnea; findings on physical exam or other evaluation


Pathologic Stage III Merkel Cell Carcinoma AJCC v8

Stage III includes: IIIA: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0); IIIB: (T1-4, N1b-3, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


First-degree perineal laceration during delivery

Injury to perineal skin only. (reVITALize)


Aerodigestive Invasive Malignancy

A finding indicating the presence of an invasive malignant neoplasm involving the respiratory tract and the upper digestive tract.


Hypothalamic Gangliocytoma

A tumor characterized by the presence of mature ganglion cells and neuronal differentiation, arising in the hypothalamus. It is often associated with the presence of pituitary gland adenomas. Symptoms include acromegaly and precocious puberty.


Solicited Adverse Event

An adverse event that is reported by a healthcare professional, consumer, or patient through an organized data collection system.


Grade 5 Gastrointestinal Stoma Necrosis, CTCAE

Death


AIDS-Related Cervical Carcinoma

A carcinoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


CNS Necrosis and Cystic Progression, CTCAE


Emaciation

An extreme loss of muscle and subcutaneous fat that is caused by malnutrition, and which results in a severely thin (emaciated) appearance.


Grade 4 Vaginal Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


P1 Hydronephrosis

Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is 10 to less than 15 mm, 2) central calyceal dilation may be present, but peripheral calyceal dilation is considered to increase risk, 3) renal parenchyma should have normal thickness and appearance, 4) the ureter is not seen, and 5) the bladder is normal. If there is central calyceal dilation but the APRPD is less than 10 mm, it is still considered UTD P1. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Anosmia, CTCAE

A disorder characterized by a change in the sense of smell.


Cheiromegaly

Abnormal enlargement of one or both hands, along with hyperhydrosis.


Grade 4 Prostate Stricture or Stenosis, CTCAE


Upper Aerodigestive Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 1 Conjunctiva Intra-Operative Injury, CTCAE


Hereditary Transthyretin Amyloid Cardiomyopathy

Transthyretin amyloid cardiomyopathy caused by mutation(s) in the TTR gene, encoding transthyretin.


Grade 4 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Bronchopulmonary Dysplasia, AE

An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND need for greater than 30% oxygen AND positive pressure at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; need for greater than 30% oxygen AND positive pressure by 56 days postnatal age in infants born greater than 32 weeks' gestation; need for greater than 30% oxygen AND positive pressure at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


Grade 1 Gastroesophageal Reflux Disease, CTCAE

Mild symptoms; intervention not indicated


Grade 1 Eye Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated; no change in vision


Stage IA Pancreatic Cancer AJCC v8

Stage IA includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Urostomy Site Bleeding, CTCAE

A disorder characterized by bleeding from the urostomy site.


Grade 2 Cranial Nerve X Neuropathy, CTCAE


Ascending Testicle

A condition in which a previously descended testicle permanently moves out of the scrotum.


Hepatic Hemorrhage, CTCAE

A disorder characterized by bleeding from the liver.


Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Necrotizing Enterocolitis, AE

An adverse event in a newborn characterized by confirmed necrotizing enterocolitis; major care change indicated (e.g. NPO, antibiotics, non-urgent surgery).


Stage IIIA Uterine Corpus Cancer AJCC v7

Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Substance Intoxication Delirium

A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance intoxication.


Lip Infection, CTCAE

A disorder characterized by an infectious process involving the lips.


Grade 5 Oral Hemorrhage, CTCAE

Death


Grade 3 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cutaneous Hematopoietic and Lymphoid Cell Neoplasm

A myeloid or lymphoid cell neoplasm involving the skin.


Pericarditis, CTCAE

A disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart).


Grade 4 Hypokalemia, CTCAE

<2.5 mmol/L; life-threatening consequences


Grade 4 Lipase Increased, CTCAE

>5.0 x ULN and with signs or symptoms


Grade 3 Fallopian Tube Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 2 Intraoperative Reproductive Tract Injury, CTCAE

Partial resection of injured organ/structure indicated


Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during adulthood.


Stage IV Vulvar Cancer AJCC v8

Stage IV includes: T1-T3, N3, M0-M1. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


Grade 4 Papulopustular Rash, CTCAE

Life-threatening consequences


Adverse Event Associated with Growth and Development


Shingles, CTCAE

A disorder characterized by the reactivation of herpes zoster virus.


Adverse Event Associated with the Nervous System


Locally Advanced Lymphoma

Lymphoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 4 Visceral Arterial Ischemia, CTCAE

Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


High Grade Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is high grade.


BCLC Stage C Hepatocellular Carcinoma

Advanced hepatocellular carcinoma.  Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41)


Prostatic Hemorrhage, CTCAE

A disorder characterized by bleeding from the prostate gland.


Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Conditioned Insomnia

Insomnia that results from a developed tendency to not sleep well under particular conditions.


Broad Ligament Serous Cystadenoma

A rare serous cystadenoma arising from the broad ligament.


Grade 3 Aortic Valve Disease, CTCAE

Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention


Grade 3 Jejunal Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated


Adenocarcinoma in situ in villous adenoma

A non-invasive adenocarcinoma arising from a villous adenoma.


Childhood Gemistocytic Astrocytoma

A gemistocytic astrocytoma that occurs during childhood.


Grade 1 Trachea Intra-Operative Injury, CTCAE


Vaginal Mesonephric Adenocarcinoma

Vaginal adenocarcinoma that derives from Wolffian duct remnants and shows mesonephric differentiation.


FIGO Stage IIB Gestational Trophoblastic Tumor


Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Adult Acquired Toxoplasmosis

Toxoplasmosis acquired in adulthood.


High Grade Sarcoma

A sarcoma with the morphologic features of a high grade tumor and lack of differentiation.


Grade 4 Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Conduction Disorder, CTCAE

A disorder characterized by pathological irregularities in the cardiac conduction system.


Grade 2 Pharyngeal Mucositis, CTCAE

Moderate pain, analgesics indicated; altered oral intake; limiting instrumental ADL


Grade 4 Extrapyramidal Disorder, CTCAE

Life-threatening consequences; urgent intervention indicated


Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Uterus Stricture or Stenosis, CTCAE


Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Infusion Related Toxicity

Toxicity related to an infusion.


Locally Recurrent Malignant Neoplasm

The reemergence of a malignant neoplasm after a period of remission at the site of the original tumor or adjacent to it.


Pediatric Obesity

A condition in which a child's body mass index (BMI) falls at or above the 95th percentile based on the normative values for the age and sex of the reference population.


Grade 5 Abdominal Infection, CTCAE

Death


Cerebellar Glioblastoma

A glioblastoma that occurs in the cerebellum.


Grade 4 Sinus Disorder, CTCAE

Necrosis of soft tissue or bone; urgent operative intervention indicated


Acute Lymphoblastic Leukemia by ROSE Cluster

Unique gene expression-based patient cluster groups in high-risk B-precursor acute lymphoblastic leukemia determined by Recognition of Outliers by Sampling Ends (ROSE).


Bilateral Proliferative Retinopathy

Proliferative retinopathy occurring in both eyes.


Grade 2 Duodenum Stricture or Stenosis, CTCAE


Stage IVB Bone Cancer AJCC v7

Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 2 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Ureter Stricture or Stenosis, CTCAE


Cervix Intraepithelial Neoplasia Grade 3 AJCC v7

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Umbilical hernia without mention of obstruction or gangrene

The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the umbilicus, without mention of obstruction or necrosis of the herniated contents.


Grade 2 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pathologic Stage IIID Cutaneous Melanoma AJCC v8

Stage IIID includes: T4b, N3a/b/c, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Locally Advanced Cervical Adenocarcinoma

A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Non-small cell carcinoma

A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma.


Tumors Derived from Langerhans Cells

This category includes two main sub-groups, according to the degree of cytological atypia and clinical aggressiveness: Langerhans cell histiocytosis and Langerhans cell sarcoma. (WHO 2017)


Racial Melanosis

A benign conjunctival finding noted especially among darker pigmented individuals. While it is typically found perilimbally and bilaterally, it can also cover the conjunctivae extensively and may present asymmetrically. The flat, non-cystic pigmentation may increase in size with age. It is rare to have this finding evolve into conjunctival melanoma.


Grade 5 Tracheal Obstruction, CTCAE

Death


Broad Ligament Wolffian Tumor

An epithelial neoplasm of Wolffian (mesonephric) origin arising from the broad ligament. Most tumors behave in a benign fashion.


Grade 1 Tendon Reflex Decreased, CTCAE

Ankle reflex reduced


Grade 3 Central Nervous System Hemorrhage, CTCAE


Grade 4 Genitourinary Stoma Obstruction, CTCAE


Grade 3 Intraoperative Neurological Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 1 Duodenum Stricture or Stenosis, CTCAE


Recurrent Acute Promyelocytic Leukemia with PML-RARA

The reemergence of acute promyelocytic leukemia with PML-RARA after a period of remission.


Chest Pain - Cardiac, CTCAE

A disorder characterized by substernal discomfort due to insufficient myocardial oxygenation e.g., angina pectoris.


Grade 3 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Atelectasis, CTCAE

Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Grade 2 Agitation, CTCAE

Moderate mood alteration


Midgut Neuroendocrine Tumor

A well differentiated, low, intermediate, or high grade neoplasm that arises from the jejunum, ileum, proximal colon, or appendix.


Grade 1 Muscular and Skeletal Hypoplasia, CTCAE


Grade 3 Retroperitoneum Hemorrhage, CTCAE


Idiopathic Dysplasia of Uncertain Significance

Prominent hematopoietic cell dysplasia with mild or absent cytopenia. It may progress to an overt myelodysplastic syndrome or other myeloid neoplasms such as acute myeloid leukemia, myeloproliferative neoplasm, or mast cell disorder.


Schizophrenia and other psychotic disorders

A category of psychiatric disorders characterized by the presence of psychotic symptoms such as delusions or hallucinations or negative symptoms such as affective flattening.


Atrioventricular Block Complete, CTCAE

A disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles.


Abnormal Finding

A decision that an observation or result is outside the parameters considered normal.


Tubal Hyperplasia

Benign proliferation of the fallopian tube epithelium.


Grade 3 Concentration Impairment, CTCAE

Severe impairment in attention or decreased level of concentration; limiting self care ADL


Trichilemmal carcinoma

A rare malignant tumor arising from the outer hair sheath and infundibulum on the face. It is considered the malignant counterpart of tricholemmoma. Complete surgical excision is required.


Grade 3 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Stage IIIB Vulvar Cancer AJCC v7

Stage IIIB includes: (T1/T2, N2a/N2b, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less.  N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Carbon Monoxide Diffusing Capacity Decreased, CTCAE

Asymptomatic decrease of >8 units drop; >5 units drop along with the presence of pulmonary symptoms (e.g., >Grade 2 hypoxia or >Grade 2 dyspnea); intervention indicated


Low Grade Gastric Intraepithelial Neoplasia

A gastric intraepithelial lesion characterized by the presence of neoplastic cells with mild cytologic atypia, mild architectural changes, and low number of mitotic figures.


Laryngeal Hemorrhage, CTCAE

A disorder characterized by bleeding from the larynx.


Anaplastic Large Cell Lymphoma, Lymphomatoid Papulosis-Like Histology

An anaplastic large cell lymphoma characterized by the presence of histopathologic features reminiscent of lymphomatoid papulosis. These features include the presence of Hodgkin-like cells in a background of acute and chronic inflammation.


Grade 3 Ascites, CTCAE

Severe symptoms; invasive intervention indicated


Sinus Tachycardia, CTCAE 5.0

A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node.


Hodgkin's disease, lymphocytic depletion of lymph nodes of multiple sites

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Adenocarcinoma of the prostate stage III

Stage III includes: T3a-b, N0, M0, Any PSA, Any Gleason.  cT3a: Tumor with extracapsular extension (unilateral or bilateral).  pT3a: Tumor with extraprostatic extension or microscopic invasion of bladder neck.  T3b: Tumor invades seminal vesicle(s).  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Neonatal Intraventricular Hemorrhage, AE

An adverse event in a newborn characterized by bleeding into the lateral cerebral ventricles.


Grade 3 Peritoneal Cavity Intra-Operative Injury, CTCAE


Grade 1 Pleuritic Pain, CTCAE

Mild pain


Erosion lesion

An eating away or breakdown of any type of external or internal human tissue including but not limited to skin, teeth, mucosa, or somatic, which involves only the outer tissue layer. When tissue surrounds an implanted device, the tissue breakdown may result in migration and loss of the implant material and may result in further complications such as infection or abscess.


Grade 1 Myelitis, CTCAE

Asymptomatic; mild signs (e.g., Babinski's reflex or Lhermitte's sign)


Unresectable Ampulla of Vater Carcinoma

Carcinoma that arises from the ampulla of Vater and is not amenable to surgical resection.


Grade 3 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Biliary Tract Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Carcinoma Metastatic to the Skin

A carcinoma that has spread to the skin from its original site of gowth.


Grade 5 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Testicular Non-Neoplastic Disorder

A non-neoplastic disorder that affects the testis.  Representative examples include infection, torsion, and infarction.


Grade 3 Injury To Inferior Vena Cava, CTCAE

Severe symptoms; limiting self care ADL; repair or revision indicated


Hepatocellular Carcinoma by AJCC v8 Stage

A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to hepatocellular carcinomas and fibrolamellar carcinomas (fibrolamellar variant of hepatocellular carcinoma). Intrahepatic cholangiocarcinomas, combined hepatocellular-cholangiocarcinomas, and sarcomas of the liver are not staged using this staging system. (from AJCC 8th Ed.)


Endocrine Disorders - Other, Specify, CTCAE


Mucosal Infection, CTCAE

A disorder characterized by an infectious process involving a mucosal surface.


Grade 3 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Hematoma, CTCAE

Transfusion; invasive intervention indicated


Advanced Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Metastatic Melanoma

Metastatic melanoma that is resistant to treatment.


Stage IV Bone Sarcoma AJCC v7

Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 5 Fallopian Tube Obstruction, CTCAE


Pancreatic Hepatoid Adenocarcinoma

A rare adenocarcinoma that arises from the pancreas.  It is characterized by marked hepatocellular differentiation.


Stage I Ampulla of Vater Cancer AJCC v8

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2, N0, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Other Dermatology or Skin, CTCAE


Mammary duct ectasia

Dilatation of the lumen of the mammary ducts without evidence of epithelial atypia.


Kidney Pain, CTCAE

Kidney pain that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


Grade 4 Urethral Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Non-Muscle Invasive Bladder Urothelial Carcinoma

An infiltrating urothelial carcinoma of the bladder that has not invaded into the bladder muscularis propria.


Cranial Nerve VIII Intra-Operative Injury, CTCAE


Grade 1 Prolapse of Intestinal Stoma, CTCAE

Asymptomatic; reducible


Grade 5 Surgical and Medical Procedures - Other, Specify, CTCAE

Death


Grade 1 Gallbladder Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Non-Invasive Cribriform Carcinoma

A carcinoma characterized by the presence of a cribriform architectural pattern. There is no evidence of surrounding stromal invasion by the malignant cells.


Stage IVB Oral Cavity Verrucous Carcinoma


Chronic Myelomonocytic Leukemia with Eosinophilia Associated with t(5;12)(q31;p12)

Chronic myelomonocytic leukemia characterized by the presence of eosinophilia, PDGFRB gene rearrangement, and t(5;12)(q31;p12).


Grade 1 Platelet Count Decreased, CTCAE

<LLN-75,000/mm3; <LLN-75.0 x 10e9/L


Grade 3 Aspartate Aminotransferase Increased, CTCAE

>5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


Stage IVA Gallbladder Cancer AJCC v8

Stage IVA includes: T4, N0-1, M0. T4: Tumor invading the main portal vein or hepatic artery or invading two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 4 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Urinary Tract Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Mitochondrial Uncoupling Protein 2 Hyperinsulinism

Hyperinsulinism due to mutation(s) in the gene UCP2, encoding mitochondrial uncoupling protein 2, which plays a role in attenuating insulin secretion.


Supratentorial Ependymoma

A circumscribed ependymoma that arises from the supratentorial region of the brain. The diagnosis of supratentorial ependymoma should be made either when genetic analysis did not reveal a fusion gene involving ZFTA or YAP1 genes (not elsewhere classified -NEC) or when the genetic analysis was unsuccessful or not reported (not otherwise specified-NOS).


Pediatric Disorder

A non-neoplastic or neoplastic disorder which occurs during infancy, childhood, or adolescence.


Grade 4 Atrioventricular Block Complete, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Renal Colic, CTCAE

Hospitalization indicated; limiting self care ADL


Grade 5 Pleural Effusion, CTCAE

Death


Grade 4 Spinal Fracture, CTCAE

Life-threatening consequences; symptoms associated with neurovascular compromise


Grade 1 Major Visceral Artery Intra-Operative Injury, CTCAE


Grade 4 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Uterine Fistula, CTCAE

A disorder characterized by an abnormal communication between the uterus and another organ or anatomic site.


Grade 1 Breast Volume and Hypoplasia, CTCAE


Grade 3 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Libido Increased, CTCAE

A disorder characterized by an increase in sexual desire.


Columnar Cell Change of the Breast with Atypia

A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by one or two layers of columnar epithelial cells.  Cytologic atypia is present.


Grade 3 Cranial Nerve IV Intra-Operative Injury, CTCAE


Grade 1 Teeth Intra-Operative Injury, CTCAE


Grade 5 Hypophysitis, CTCAE

Death


Grade 2 Glaucoma, CTCAE

EIOP which can be reduced to 21 mmHg or under with topical medications and no visual field deficit


Grade 2 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Ear and Labyrinth Disorders - Other, Specify, CTCAE


Body Odor, CTCAE

A disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body.


leukoencephalopathy with vanishing white matter

A new leukoencephalopathy, the CACH syndrome (Childhood Ataxia with Central nervous system Hypomyelination) or VWM (Vanishing White Matter) was identified on clinical and MRI criteria. Classically, this disease is characterized by (1) an onset between 2 and 5 years of age, with a cerebello-spastic syndrome exacerbated by episodes of fever or head trauma leading to death after 5 to 10 years of disease evolution, (2) a diffuse involvement of the white matter on cerebral MRI with a CSF-like signal intensity (cavitation), (3) a recessive autosomal mode of inheritance, (4) neuropathologic findings consistent with a cavitating orthochromatic leukodystrophy with increased number of oligodendrocytes with sometimes ``foamy'' aspect.


Asymptomatic Inflammatory Prostatitis

Inflammation of the prostate gland that is not associated with any symptoms. It is characterized by the presence of inflammatory cells in the prostatic fluid.


Extramural Nodule

A small aggregate of cells found in adipose tissues, particularly those attached to the colon where the architectural details of the lymph node cannot be identified with certainty under the microscope.  It may represent a lymph node completely replaced by metastatic cancer.


Complete unbalanced atrioventricular canal defect

Atrioventricular septal defect in which there is usually a single dominant ventricle and a hypoplastic ventricle.


Refractory Cytomegalovirus Infection

A cytomegalovirus infection that is resistant to treatment.


Grade 5 Malabsorption, CTCAE

Death


Liver Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the liver. The Ki-67 index is higher than 20%.


Serum Glutamic Pyruvic Transaminase, CTCAE


AIDS-Related Diffuse Large Cell Lymphoma

A diffuse large cell lymphoma developing in an HIV positive patient.


Grade 2 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Fat Atrophy, CTCAE

Covering >30% BSA; associated with erythema or tenderness; limiting self-care ADL


Full supernumerary rib

Presence of rib formation in the lumbar region.


Grade 2 Oral Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 5 Conduction Disorder, CTCAE

Death


Deletion of Chromosome 22 Associated Meningioma

A meningioma that is associated with deletion of chromosome 22.  This abnormality is the most consistent cytogenetic finding that is detected in meningiomas.


Mouth cyst

A cystic lesion located in the oral cavity.


Stage II Vaginal Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor invades paravaginal tissues but not to pelvic wall.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IB Merkel Cell Carcinoma AJCC v7

Stage IB includes: T1, cN0, M0.  T1: Primary tumor equal or less than 2 cm in size.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Erectile Dysfunction, CTCAE

A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity.


Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IV Ampulla of Vater Cancer AJCC v7

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis.  (from AJCC 7th Ed.)


FEV1, CTCAE

An adverse event marked by a change in FEV1 lung function.


Grade 1 Spermatic Cord Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Bone Schwannoma

A very rare schwannoma of the bone. It is often located in the mandible and is well circumscribed.


Grade 1 Lens Intra-Operative Injury, CTCAE


Esophageal dysplasia

A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma.  Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade.  In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications.  (WHO, 2000)


Melanocytic matricoma

A rare benign pilar tumor with numerous intratumoral pigmented dendritic melanocytes. It typically affects elderly men. The most common location is the head and neck, followed by the trunk and the limbs. It manifests as a small, pigmented, purple or brownish-black papule or nodule. (WHO 2018)


Grade 3 Proptosis and Enophthalmos, CTCAE


Uterine Infection, CTCAE

A disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues.


Precursor T-lymphoblastic lymphoma/leukemia stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in a with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Radiating Chest Pain Along Left Lower Sternal Border

The location of the radiating chest pain is along the left lower sternal border.


Grade 4 Intraoperative Cardiac Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Larynx Obstruction and Stenosis, CTCAE


Childhood Malignant Solid Neoplasm

A malignant solid neoplasm that occurs during childhood.


Suicide Attempt, CTCAE

A disorder characterized by self-inflicted harm in an attempt to end one's own life.


Grade 4 Renal Calculi, CTCAE

Life-threatening consequences; urgent invasive intervention indicated


Infant Acute Undifferentiated Leukemia

An acute undifferentiated leukemia that occurs in infancy.


Grade 1 Prolapse of Gastrointestinal Stoma, CTCAE


Grade 5 Tracheitis, CTCAE

Death


Acute gastritis

Acute inflammation of the stomach.


Periodontal Disease, CTCAE

A disorder in the gingival tissue around the teeth.


Stage IIIA Ampulla of Vater Cancer AJCC v8

Stage IIIA includes: (T1a, N1, M0); (T1b, N1, M0); (T2, N1, M0); (T3a, N1, M0); (T3b, N1, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N1: Metastasis to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Argentaffinoma

A carcinoid tumor that shows atypical characteristics and has borderline malignant potential.


Zonular dehiscence

Rupture of the fibrous strands connecting the ciliary body and the crystalline lens of the eye.


Closed dislocation

A dislocation not complicated by an external wound


Grade 1 Tremor, CTCAE

Mild symptoms


Sickle Beta 0 Thalassemia

A form of sickle cell thalassemia characterized by the absence of hemoglobin A. Patients usually have severe anemia identical to that seen in sickle cell disease.


Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


Substance-induced sleep disorder

A sleep disorder (insomnia, hypersomnia, or parasomnia) for which there is strong evidence that the disorder is etiologically linked to the direct physiological effects of a substance (i.e., a drug of abuse, a medication, or toxin exposure).


Unresectable Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma that is not amenable to surgical resection.


Grade 5 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Infant Acute Lymphoblastic Leukemia without MLL Gene Rearrangement

An acute lymphoblastic leukemia without rearrangement of the MLL (KMT2A) gene that occurs in infancy.


Grade 4 Pneumonitis and Pulmonary Infiltrates, CTCAE


Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malposition of uterus

Orientation of the uterus in an unusual anatomic location or position.


Facial Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the face.


Grade 3 Bronchopulmonary Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Refractory acute myeloid leukemia

Acute myeloid leukemia that does not respond to treatment.


Grade 1 Ureter Stricture or Stenosis, CTCAE


Grade 2 Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage III Fallopian Tube Cancer AJCC v8

Stage III includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0; IIIB: T3b, N0/N1, M0; IIIC: T3c, N0/N1, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Type II Total Anomalous Pulmonary Venous Return

Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the coronary sinus.


Grade 5 Other Sexual Reproductive Function, CTCAE


Grade 5 Gallbladder Necrosis, CTCAE

Death


Hepatocyte Nuclear Factor 4-Alpha Hyperinsulinism

Hyperinsulinism due to mutation(s) in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4-alpha. This condition may progress to diabetes later in life.


Grade 1 Paresthesia, CTCAE

Mild symptoms


Lateral developmental cyst of jaw

A developmental odontogenic cyst lined by non-keratinized epithelium, occurring on the lateral aspect or between the roots of erupted teeth. (WHO 2017)


Grade 4 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cystine urolithiasis

Urolithiasis in which the composition of the stones is predominantly cystine.


Renal Pelvis and Ureter Cancer by AJCC v8 Stage

A term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to renal pelvis and ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. It does not apply to renal cell carcinomas (are staged according to the classification for kidney), renal medullary carcinomas (are staged according to the classification for kidney), collecting duct carcinomas (are staged according to the classification for kidney),  lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and mesenchymal tumors (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs). (from AJCC 8th Ed.)


Grade 4 Hepatitis Viral, CTCAE

Life-threatening consequences; severe decompensated liver function (e.g., coagulopathy, encephalopathy, coma)


Megacystis - Megaureter

A condition characterized by a large capacity, thin-walled bladder and megaureter(s).


Grade 1 Larynx Obstruction and Stenosis, CTCAE


Grade 3 Vaginal Stenosis and Length, CTCAE


Grade 3 Papulopustular Rash, CTCAE

Papules and/or pustules covering >30% BSA with moderate or severe symptoms; limiting self-care ADL; IV antibiotics indicated


Condyloma Acuminatum with Dysplasia

Condyloma acuminatum that is associated with the presence of dysplastic epithelial changes.


Adenoma, Trabecular

A benign epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern.


Recurrent Adult Brain Neoplasm

The reemergence of brain neoplasm in adulthood after a period of remission.


Stage 0is Urethral Cancer AJCC v8

Stage 0is includes: Tis, N0, M0. Tis: For male penile urethra and female urethra: Carcinoma in situ. For prostatic urethra: Carcinoma in situ involving the prostatic urethra or periurethral or prostatic ducts without stromal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Stage I Ureter Cancer AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Gingival Pain, CTCAE

Severe pain; inability to aliment orally


Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Retinopathy of Prematurity, AE

An adverse event in a newborn characterized by bilateral retinal detachment and blindness.


Adenocarcinoma in villous adenoma

A non-invasive or invasive adenocarcinoma arising from a villous adenoma.


Advanced Anal Canal Squamous Cell Carcinoma

Anal canal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IB Osteosarcoma AJCC v7

Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


FIGO Stage IIIA Gestational Trophoblastic Tumor


Grade 4 Neonatal Respiratory Distress Syndrome, AE

A respiratory distress adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; requiring urgent care change (e.g. urgent intubation).


Grade 4 Hip Fracture, CTCAE

Life-threatening consequences; symptoms associated with neurovascular compromise


Grade 4 Hypothyroidism, CTCAE

Life-threatening consequences; urgent intervention indicated


Recurrent Small Cell Neuroendocrine Carcinoma

The reemergence of small cell neuroendocrine carcinoma after a period of remission.


Grade 2 Non-Cardiac Chest Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 2 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acquired Cataract

Cataract that results from the aging process, an injury, or as a manifestation of a systemic disorder.


Oropharyngeal Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the oropharynx.


Stage IIIC1 Cervical Cancer FIGO 2018

Cervical carcinoma with pelvic lymph node metastasis only. (FIGO 2018)


Grade 1 Gamma-Glutamyl Transpeptidase, CTCAE


Stage IIA Gastric Cancer AJCC v7

Stage IIA includes: (T3, N0, M0); (T2, N1, M0); (T1, N2, M0). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 3 Injection Site Reaction or Extravasation Changes, CTCAE


Grade 2 Flashing Lights, CTCAE

Limiting instrumental ADL


Death Neonatal, CTCAE

Newborn death occurring during the first 28 days after birth.


Grade 1 Vaginal Dryness, CTCAE

Mild vaginal dryness not interfering with sexual function


Locally Advanced Adenoid Cystic Carcinoma

Adenoid cystic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Ampulla of Vater Hepatoid Adenocarcinoma

A very rare adenocarcinoma that arises from the ampulla of Vater.  It is usually of the intestinal type and is characterized by the presence of malignant polygonal cells with abundant eosinophilic cytoplasm resembling hepatocytes.


Grade 3 Rectal Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Pharyngeal Mucositis, CTCAE

A disorder characterized by ulceration or inflammation involving the mucous membrane of the pharynx.


Stage IA Bone Sarcoma AJCC v7

Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 3 Weight Loss, CTCAE

>=20% from baseline; tube feeding or TPN indicated


Locally Advanced Fallopian Tube Carcinoma

Fallopian tube carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Small Intestinal Perforation, CTCAE 5.0

A disorder characterized by a rupture in the small intestine wall.


Bladder Endometrioid Adenocarcinoma

A rare bladder adenocarcinoma with the histologic characteristics of endometrioid adenocarcinoma of the endometrium.


Lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Metastatic Neuroendocrine Neoplasm

A neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Appendix Tubular Carcinoid

A neuroendocrine tumor that arises from the appendix.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


Grade 2 Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Merkel Cell Carcinoma by AJCC v8 Pathologic Stage

A term that refers to the pathologic staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


Grade 3 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Small Intestinal Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Uterine Anastomotic Leak, CTCAE

Death


Grade 5 Carbon Monoxide Diffusion Capacity, CTCAE


Smoldering Systemic Mastocytosis

Slowly progressive systemic mastocytosis with uncertain prognosis. It is characterized by organomegaly and absence of aggressive disease.


Grade 4 Platelet Count Decreased, CTCAE

<25,000/mm3; <25.0 x 10e9/L


Fibrinogen Decreased

A laboratory test result which indicates decreased levels of fibrinogen in a biological specimen.


Larynx Edema, CTCAE

Laryngeal edema resulting from a known treatment.


Obesity, CTCAE

A disorder characterized by having a high amount of body fat.


Fibrolipoma

A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue.


Stage IIA Testicular Cancer AJCC v8

Stage IIA includes: (Any pT/TX, N1, M0, S0); (Any pT/TX, N1, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Adult Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for adult Hodgkin lymphoma based on the Ann Arbor classification criteria.


Grade 2 Localized Edema, CTCAE

Moderate localized edema and intervention indicated; limiting instrumental ADL


Body Fluid Leakage

The loss of any normal body fluid into the surrounding tissue or body cavity.


Stage IVA Cervical Cancer AJCC v9

Stage IVA includes: T4, Any N, M0. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 1 Peripheral Sensory Neuropathy, CTCAE

Asymptomatic


Prostate Adenocarcinoma with Neuroendocrine Differentiation

An invasive prostate adenocarcinoma characterized by the presence of malignant cells that exhibit neuroendocrine differentiation.


Psychological Dependence

A behavioral pattern characterized by a craving for the mood-altering effects of a drug and an overwhelming preoccupation with obtaining and using the drug.


Grade 3 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Pleura Intra-Operative Injury, CTCAE


Grade 1 Lethargy, CTCAE

Mild symptoms; reduced alertness and awareness


Grade 1 Haptoglobin Decreased, CTCAE

<LLN


Congenital postural scoliosis

Abnormal sideways curvature of the spine that is present at birth.


Grade 4 Seizure, CTCAE

Life-threatening consequences; prolonged repetitive seizures


Grade 5 Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cellular Blue Nevus

A blue nevus characterized by a multinodular cellular infiltrate with a dumb-bell architecture occupying the reticular dermis. The cellular infiltrate often extends into the subcutaneous tissue. The cellular infiltrate is composed of spindle-shaped melanocytes with pale cytoplasm alternating with bundles of pigmented spindle-shaped melanocytes. In occasional cases an increased mitotic activity, focal necrosis, and nuclear pleomorphism may be seen. Such cases with atypical features may have an uncertain malignant potential.


Bronchopulmonary Hemorrhage, CTCAE

A disorder characterized by bleeding from the bronchial wall and/or lung parenchyma.


Grade 3 Pain of Skin, CTCAE

Severe pain; limiting self care ADL


Eye Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the eye.


Grade 3 Other Growth and Development, CTCAE


Grade 1 Scrotal Infection, CTCAE

Localized, local intervention indicated


Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intestinal Stoma Prolapse

An intestinal stoma complication characterized by protrusion of the intestine above the abdominal surface.


Elevated CA19-9

A laboratory test result indicating the presence of an increased level of the tumor-associated antigen (TAA) CA19-9 in a biological sample.


Grade 3 Neonatal Culture Positive Sepsis, AE

An adverse event in a newborn characterized by a positive blood culture positive with severe signs; supportive treatment escalated or initiated.


Grade 3 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Carcinoma in the Peritoneum

A carcinoma that has spread to the peritoneum from an adjacent or distal anatomic site.


Laryngitis, CTCAE

A disorder characterized by an inflammatory process involving the larynx.


Grade 3 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Clinical Stage IV Retinoblastoma AJCC v8

Stage IV includes: Any cT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Stage I Renal Pelvis and Ureter Cancer AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent Endometrial Transitional Cell Carcinoma

The reemergence of endometrial transitional cell carcinoma after a period of remission.


Refractory Low Grade Glioma

Low grade glioma that is resistant to treatment.


Oxyntic Gland Adenoma

A benign epithelial neoplasm composed of columnar cells with differentiation to chief cells, parietal cells, or both, with a high rate of progression to adenocarcinoma (submucosal invasion). (WHO 2019)


Adult Non-T Non-B Acute Lymphoblastic Leukemia

Non-T non-B acute lymphoblastic leukemia that occurs during adulthood.


Stage IIB Digestive System Neuroendocrine Tumor AJCC v7

Stage IIB includes: T3, N0, M0.  T3: Stomach: tumor penetrates subserosa; jejunum/ileum: tumor invades through the muscularis propria into subserosal tissue without penetration of overlying serosa or invades into non-peritonealized tissues; ampulla/duodenum: tumor invades pancreas or retroperitoneum or into non-peritonealized tissues; colon or rectum: tumor invades through the muscularis propria into the subserosa, or into non-peritonealized pericolic or perirectal tissues. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Non-Obstructed Non-Refluxing Megaureter

A megaureter in which there is no obstruction at the ureterovesical junction and no vesicoureteral reflux.


Hodgkin's disease nodular sclerosis stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Grade 2 Joint Infection, CTCAE

Localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral); needle aspiration indicated (single or multiple)


Grade 2 White Blood Cell Decreased, CTCAE

<3000-2000/mm3; <3.0-2.0 x 10e9/L


Endometrial Endometrioid Adenocarcinoma with an Undifferentiated Carcinomatous Component

A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with undifferentiated malignant cells.


Stage III Gastric Neuroendocrine Tumor AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IB2 Cervical Cancer

Stage IB2 includes: T1b2, N0, M0.  T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 3 Suicidal Ideation, CTCAE

Specific plan to commit suicide without serious intent to die which may not require hospitalization


Lugano Classification Stage I Childhood Hodgkin Lymphoma AJCC v8

Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Creatinine Increased, CTCAE

>1.5-3.0 x baseline; >1.5-3.0 x ULN


High Grade Esophageal Glandular Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal glandular epithelium.


Grade 1 Urticaria, CTCAE

Urticarial lesions covering <10% BSA; topical intervention indicated


Grade 4 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Neonatal Culture Negative Sepsis, AE

An adverse event in a newborn characterized by suspected sepsis with severe signs (e.g. fever, grunting); supportive treatment escalated or initiated.


Grade 4 Lower Gastrointestinal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Mediastinum Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 1 Ear Pain, CTCAE

Mild pain


Passive-Aggressive Personality Disorder

A disorder characterized by a pattern of indirect expression of hostility, including negativistic attitudes and passive resistance to demands for adequate performance in social and occupational situations.


Grade 5 Hepatitis B Reactivation, CTCAE

Death


Grade 4 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pneumonitis, CTCAE

Severe symptoms; limiting self care ADL; oxygen indicated


Grade 1 Cecal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 1 Investigations - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 3 Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


Adverse Event Attributed to Commercial Product

An indication that an adverse event is causally related to the use of a commercially available product.


Refractory Sarcoma

A sarcoma that does not respond to treatment.


Esophageal mucositis

An inflammatory process affecting the mucous membrane of the esophagus.


Transferase Deficiency Galactosemia

A disorder characterized by the body's inability to metabolize galactose. This type of galactosemia is caused by germline mutations in the GALT gene which leads to the inhibition in the activity of the enzyme galactose-1-phosphate uridyl transferase.


Hip Fracture, CTCAE

A finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken.


Radiating Chest Pain in Back

The location of the radiating chest pain is in the back.


BCOR ITD Sarcoma

A group of rare primitive round cell sarcomas characterized by the presence of BCOR internal tandem duplication. This genetic alteration has been described in infantile undifferentiated round cell sarcomas and primitive myxoid mesenchymal tumors of infancy.


Adult Liver Carcinoma

A hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood.


Refractory Langerhans Cell Histiocytosis

Langerhans cell histiocytosis that does not respond to treatment.


Mast Cell Leukemia Associated with Another Hematological Neoplasm

Mast cell leukemia associated with another clonal non-mast cell hematologic neoplasm (e.g., myelodysplastic syndrome, chronic myeloproliferative disorder, acute myeloid leukemia, and lymphoma).


Liver Neuroendocrine Neoplasm

An extremely rare neoplasm with neuroendocrine differentiation that arises from the liver. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Grade 1 Bladder Stricture or Stenosis, CTCAE


Grade 5 Cranial Nerve X Neuropathy, CTCAE


Extrahepatic bile duct cancer stage I

Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0).  T1: Tumor confined to the bile duct histologically.  T2: Tumor invades beyond the wall of the bile duct.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Grade 2 Dental Caries, CTCAE

Dental caries involving the root


Stage IIB Prostate Cancer AJCC v8

Stage IIB includes: T1-2, N0, M0, PSA less than 20, Grade Group 2. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. (AJCC 8th ed.)


Ocular Graft Versus Host Disease

Graft versus host disease occurring in the eye.


Stage IB Uterine Corpus Cancer AJCC v7

Stage IB includes: T1b, N0, M0.  T1b: Tumor invades one-half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Pancreatobiliary Carcinoma

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater.


Refractory Acute Bilineal Leukemia

Acute bilineal leukemia that is resistant to treatment.


Grade 3 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Endometrial Carcinoma

Endometrial carcinoma that is resistant to treatment


Grade 2 Azoospermia, CTCAE

Absence of sperm in ejaculate