Proliferative dermal lesion in congenital nevus

A benign proliferation of epithelioid or spindled melanocytes usually in the upper or mid dermis in a background of congenital melanocytic nevus. The congenital melanocytic nevus is usually of the deep type, involving the dermis and extending into the subcutaneous tissue. It presents as a dark plaque or nodule above a giant congenital melanocytic nevus.


Central Nervous System Solitary Fibrous Tumor, Grade 1

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

A solitary fibrous tumor that arises from the central nervous system. It corresponds most often to the collagenous and low cellularity spindle cell tumor which was diagnosed as central nervous system solitary fibrous tumor in the past.


Grade 2 Eyelid Dysfunction, CTCAE

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon


Stomach Mass

An abnormal growth located in the stomach.


Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Refractory Fungal Infection

A fungal infection that is resistant to treatment.


Renal Benign Mesenchymoma

A benign mesenchymoma arising from the kidney.


Mild Bronchopulmonary Dysplasia

A chronic lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates exposed to supplemental oxygen for at least 28 days. For infants born before 32 weeks gestation with mild BPD, there is no supplemental oxygen requirement at 36 weeks postmenstrual age or earlier discharge. For infants born after 32 weeks with mild BPD, there is no supplemental oxygen requirement at 56 days post-natal age or at earlier discharge.


H influenze type B Pneumonia

Pneumonia that is attributed to the bacteria H influenze type B.


Collapsed Lung

Atelectasis of an entire lung.


Somatoform autonomic dysfunction - respiratory tract

A respiratory malfunction for which mental factors play a causative role.


Acute pneumonia

Acute inflammation of the lung parenchyma caused by viruses, bacteria, fungi, radiation treatment, or exposure to chemicals.  Signs and symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness.


Non-Neoplastic Lung Disorder

A lung disorder not caused by a neoplasm. Representative examples include chronic obstructive pulmonary disease, atelectasis, lung infections, pulmonary fibrosis, and pneumoconiosis.


Follicular Bronchitis/Bronchiolitis

A non-neoplastic disorder characterized by the formation of reactive lymphoid follicles adjacent to distal bronchi and bronchioles.  It presents with mild shortness of breath and is associated with immunodeficiency syndromes and collagen vascular disorders.


COVID-19-Associated Pneumonia

Pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is characterized by the presence of ground glass opacities on CT scan images.


Congenital anomaly of lung

A malformation in the lung that is present at birth. Representative examples include pulmonary hypoplasia, pulmonary agenesis, congenital lobar emphysema, and alveolar capillary dysplasia.


Pulmonary alveolitis

Inflammation of the alveoli of the lung.


Respiratory Failure Related to Neuromuscular Disorder

Impaired gas exchange by the respiratory system resulting in hypoxemia and decreased oxygenation of the tissues that may be associated with increased arterial levels of carbon dioxide; the respiratory failure is due to a neuromuscular disorder.


Paracicatricial Emphysema

The development of dilated terminal airspaces in the lung adjacent to parenchymal scarring.


Chronic obstructive asthma (with obstructive pulmonary disease)

Chronic airway obstruction caused by asthma.


Steroid-Refractory Pneumonitis

Pneumonitis that does not respond to corticosteroid therapy.


Tuberculous bronchiectasis

Bronchiectasis that develops in patients with a history of pulmonary tuberculosis.  It is usually associated with healed scars but occasionally may be seen in patients with active pulmonary tuberculosis.


Severe acute respiratory infection

A respiratory infectious disorder that leads to an acute illness that requires medical attention.


Severe Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia that results in severe respiratory complications. The infants with severe symptoms are usually premature, have low birth weight, and the oxygen and ventilation support requirements are increased.


Pneumonia due to methicillin resistant Staphylococcus aureus

Pneumonia that is caused by Staphylococcus aureus that is resistant to methicillin treatment.


Asbestos-Related Lung Disorder

A disorder affecting the lungs due to asbestos exposure. Examples include asbestosis and lung carcinoma.


Toxoplasma Pneumonia

Pneumonia caused by the parasite Toxoplasma gondii.  It usually presents as an opportunistic infection in immunocompromised patients, especially patients with AIDS.  It is rare in immunocompetent individuals.  Signs and symptoms include cough, fever, and dyspnea.


Pulmonary trunk hypoplasia

Underdeveloped pulmonary arteries.


Respiratory Failure Related to Central Nervous System Disorder

Impaired gas exchange by the respiratory system resulting in hypoxemia and decreased oxygenation of the tissues that may be associated with increased arterial levels of carbon dioxide; the respiratory failure is due to a central nervous system disorder.


Sickle Cell Chronic Lung Disease

A pulmonary complication of sickle cell disease characterized by radiographic interstitial abnormalities and impaired pulmonary function. In severe cases, pulmonary hypertension is present.


Hyaline Membrane Syndrome

A serious disorder affecting newborns, particularly premature infants. It is caused by deficiency of surfactant, resulting in the formation of a membrane in the alveoli lining. This membrane contains fibrin and cellular debris and interferes with respiration. Infants with this disorder develop breathing problems immediately or in a few hours after delivery. It may lead to respiratory failure.


Fibrotic Hypersensitivity Pneumonitis

Interstitial lung fibrosis resulting from chronic hypersensitivity pneumonitis.


AIDS-Related Pneumocystis Pneumonia

A serious AIDS-related opportunistic infection of the lungs, caused by Pneumocystis jirovecii.  It is one of the most common AIDS-related illnesses and is a major cause of morbidity in patients with AIDS.  Signs and symptoms include cough, fever, dyspnea, and pain or tightness in the chest.


Pulmonary Precancerous Condition

A premalignant pathologic process that affects the lungs.  This category includes bronchial intraepithelial neoplasia and atypical adenomatous hyperplasia.


Grade 4 Venous Injury, CTCAE

Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


Mesothelial hyperplasia

A hyperplasia of the mesothelial cells.


Atypical Mesothelial Hyperplasia

An atypical hyperplasia of the mesothelial cells.


Infectious Salpingitis

An acute or chronic infectious process affecting the fallopian tube. Chlamydia trachomatis, Neisseria gonorrhea, Mycoplasma, Staphylococcus, and Streptococcus are the most common causative agents.


mitomycin

A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.


onium betaine

Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


Acetylcarnitine

An O-acylcarnitine having acetyl as the acyl substituent.


saturated fatty acyl-L-carnitine

An O-acylcarnitine in which the R is a saturated fatty acyl chain.


Thiamine pyrophosphate

An ammonium betaine that is the conjugate base of thiamine(1+) diphosphate arising from the deprotonation of one of the hydroxy groups of the terminal phosphate group.


O-acylcarnitine

Any carboxylic ester obtained by the O-acylation of carnitine.


Thiaminium carboxylate betaine

An ammonium betaine that is the conjugate base of thiamine(1+) carboxylic acid arising from the deprotonation of the carboxy group.


amino-acid betaine

Any amino acid-derived zwitterion - such as glycine betaine (N,N,N-trimethylammonioacetate) - in which the ammonium nitrogen carries methyl substituents and bears no hydrogen atoms.


fatty acyl-L-carnitine

Any O-acylcarnitine in which the carnitine component has L-configuration and the acyl group is a fatty acid.


Carnitine

An amino-acid betaine that is butanoate substituted with a hydroxy group at position C-3 and a trimethylammonium group at C-4.


Thiamine triphosphorate

An ammonium betaine that is the conjugate base of thiamine(1+) triphosphate arising from the deptoronation of one of the hydroxy groups of the terminal phosphate group.


Thiamine phosphoric acid ester

An ammonium betaine that is the conjugate base of thiamine(1+) monophosphate arising from the deprotonation of one of the phosphate hydroxy groups.


O-acyl-L-carnitine

An O-acylcarnitine in which the carnitine component has L-configuration.


sulfonium betaine

Neutral molecules having charge-separated forms with an sulfonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


ammonium betaine

Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


Grade 4 Intra-Abdominal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Rectal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Rectal Hemorrhage, CTCAE

A disorder characterized by bleeding from the rectal wall and discharged from the anus.


Grade 1 Rectal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 5 Rectal Hemorrhage, CTCAE

Death


Grade 2 Rectal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Childhood Mature Teratoma

A mature teratoma occurring in children.


Childhood Immature Teratoma

An immature teratoma occurring in children.


Childhood Choriocarcinoma

A choriocarcinoma occurring in children.


Refractory Childhood Malignant Germ Cell Tumor

A malignant germ cell tumor that occurs during childhood and is resistant to treatment.


Childhood Malignant Testicular Germ Cell Tumor

A malignant germ cell tumor in children arising from the testis.  It includes the embryonal carcinoma, yolk sac tumor, choriocarcinoma, and mixed germ cell tumors.


Recurrent Childhood Malignant Germ Cell Tumor

The reemergence of a malignant germ cell tumor in children after a period of remission.


Childhood Germinomatous Germ Cell Tumor

A germinomatous germ cell tumor occurring in children.


Childhood Mixed Germ Cell Tumor

A mixed germ cell tumor occurring in children.


Childhood Extracranial Germ Cell Tumor

A childhood benign or malignant germ cell tumor arising from an anatomic site other than the brain.


Childhood Teratoma

A mature or immature teratoma occurring in children.


Childhood Seminoma

A seminoma occurring in children.


Childhood Embryonal Carcinoma

An embryonal carcinoma occurring in children.


Childhood Extragonadal Malignant Germ Cell Tumor

A malignant germ cell tumor in children arising from an anatomic site other than the testis or ovary.


Childhood Central Nervous System Teratoma

A mature or immature teratoma affecting the central nervous system and occurring in children.


Benign Childhood Germ Cell Tumor

A non-metastasizing germ cell tumor that occurs during childhood.


Childhood Nongerminomatous Germ Cell Tumor

A nongerminomatous germ cell tumor occurring in children.


Childhood Testicular Non-Seminomatous Germ Cell Tumor

A non-seminomatous germ cell tumor that arises in the testis and occurs in children.


Childhood Testicular Yolk Sac Tumor

A yolk sac tumor that arises from the testis during childhood.


Peripheral Nervous System Infectious Disorder

An infectious process affecting the peripheral nerves.


Grade 5 Renal Calculi, CTCAE

Death


B-Cell Malignant Neoplasm

A clonal lymphoproliferative disorder composed of neoplastic B-cells. It includes B-cell non-Hodgkin lymphomas, B-cell leukemias, and plasma cell myeloma.


Chronic lymphocytic leukemia stage 1

Risk: Intermediate; Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


DS Stage IA Plasma Cell Myeloma

Durie/Salmon stage I plasma cell myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


B Acute Lymphoblastic Leukemia with t(4;11)(q21;23)

A B-cell acute lymphoblastic leukemia associated with t(4;11)(q21;23). This translocation leads to the generation of the fusion gene MLL-AF4.


Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

A B-cell acute leukemia occurring in childhood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


Hypodiploid B Acute Lymphoblastic Leukemia

A B-cell acute leukemia characterized by the presence of lymphoblasts which contain less than 46 chromosomes. It occurs in both children and adults. It has an unfavorable clinical outcome.


Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Chronic lymphocytic leukemia/small lymphocytic lymphoma that does not respond to treatment.


Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

The reemergence of chronic lymphocytic leukemia/small lymphocytic lymphoma after a period of remission.


Refractory B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

B-acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 that is resistant to treatment.


Leptomeningeal myelomatosis

A central nervous system plasma cell myeloma involving the leptomeninges.


Refractory B Acute Lymphoblastic Leukemia

B-acute lymphoblastic leukemia that does not respond to treatment.


DS Stage IIIB Plasma Cell Myeloma

Durie/Salmon stage III plasma cell myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder

A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed B-lymphocytes or plasma cells. The clonal cellular infiltrates fulfill the criteria for a diffuse large B-cell lymphoma, Burkitt lymphoma, or a plasma cell neoplasm.


Extramedullary Disease in Plasma Cell Myeloma Involving the Central Nervous System

Plasma cell myeloma involving the central nervous system. It manifests with single or multiple intraparenchymal lesions and/or leptomeningeal involvement. Patients present with diffuse cerebral dysfunction and nerve paralysis. The prognosis is poor.


Stage A Chronic Lymphocytic Leukemia

Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

Chronic lymphocytic leukemia characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


Refractory B-Cell Prolymphocytic Leukemia

B-cell prolymphocytic leukemia that is resistant to treatment.


Chronic Lymphocytic Leukemia- Binet Staging System

A term that refers to the staging of chronic lymphocytic leukemia according to Binet staging system. This system is in wide use outside the United States.


Chronic lymphocytic leukemia stage 4

Risk: High; Findings: Lymphocytosis and platelets less than 100,000/microliter; Survival (months): 30. (from AJCC 8th Ed.)


Cutaneous B Lymphoblastic Leukemia/Lymphoma

B-lymphoblastic leukemia/lymphoma that arises from the skin.


Stage B Chronic Lymphocytic Leukemia

Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


Plasma Cell Myeloma Post-Transplant Lymphoproliferative Disorder

A lymphoproliferative disorder that develops following an organ transplantation and exhibits plasma cell myeloma features.


Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorder

A plasmacytoma-like hematologic malignancy that arises in a patient with a history of organ transplantation.


Chronic lymphocytic leukemia stage 2

Risk: Intermediate; Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


Adult B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

A B-cell acute leukemia that occurs during adulthood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


RISS Stage I Plasma Cell Myeloma

Serum beta-2-microglobulin less than 3.5 mg/L and serum albumin 3.5 g/dL or more and no high-risk cytogenetics and normal LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


DS Stage IIB Plasma Cell Myeloma

Durie/Salmon stage II plasma cell myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation

A chronic lymphocytic leukemia characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology.


Extramedullary Disease in Plasma Cell Myeloma

Infiltration of organs and soft tissues by malignant (clonal) plasma cells in patients with history of plasma cell myeloma. Skin, liver, lymph nodes, pleura, and central nervous system are the most frequently affected sites.


Sinonasal Plasmacytoma

A plasmacytoma that arises in the sinonasal tract.


DS Stage IIA Plasma Cell Myeloma

Durie/Salmon stage II plasma cell myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


Progressive Hairy Cell Leukemia Initial Treatment

A hairy cell leukemia requiring initial treatment because of the presence of signs of progression.  Signs of progression include cytopenia (especially if symptomatic), increasing splenomegaly, and infectious complications.  Therapy is not necessary if the patients are asymptomatic and the blood counts are maintained in an acceptable range.


Refractory Transformed Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia which has undergone histologic transformation to an aggressive diffuse large B-cell lymphoma (Richter's transformation) and has become resistant to treatment.


Primary cutaneous plasmacytoma

A plasmacytoma that arises in the skin.


Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

Chronic lymphocytic leukemia characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.


Testicular Plasmacytoma

A rare plasmacytoma that arises in the testis. At presentation the involvement is usually unilateral.


DS Stage II Plasma Cell Myeloma

Plasma cell myeloma that fits in neither stage I nor stage III.  Estimated myeloma cell mass: 0.6 to 1.2 trillion (1012)/m2 (intermediate burden).  The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL.  Impaired renal function worsens prognosis regardless of stage.  Note that the newer International Staging System defines stage II quite differently: Beta-2-microglobulin less than 3.5 and albumin less than 3.5 or beta-2-microglobulin 3.5 to less than 5.5 (median survival of 44 months).  (PDQ)


Chronic lymphocytic leukemia refractory

Chronic lymphocytic leukemia that is resistant to treatment.


Recurrent B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

The reemergence of B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 after a period of remission.


Extramedullary Disease in Plasma Cell Myeloma Involving the Uterine Corpus

Infiltration of the uterine corpus by malignant (clonal) plasma cells in patients with history of plasma cell myeloma.


Chronic Lymphocytic Leukemia- Modified Rai Staging System

A term that refers to the staging of chronic lymphocytic leukemia according to modified Rai staging system. This system is mainly used in North America.


Chronic lymphocytic leukemia stage 3

Risk: High; Findings: Lymphocytosis and hemoglobin less than 11 g/dL; Survival (months): 30. (from AJCC 8th Ed.)


RISS Stage II Plasma Cell Myeloma

Not stage I or III. (from AJCC 8th Ed.)


Plasma Cell Myeloma by ISS Stage

A header term that refers to the staging of plasma cell myeloma according to the International Staging System.


Recurrent Burkitt Leukemia

The reemergence of Burkitt leukemia after a period of remission.


Plasma Cell Post-Transplant Lymphoproliferative Disorder

A plasma cell neoplasm that arises in a patient with a history of organ transplantation.


Plasma Cell Myeloma by RISS Stage

A staging system for plasma cell myeloma based on the Revised International Staging System (RISS) criteria. This staging system does not apply to smoldering multiple myeloma (no AJCC staging system), monoclonal gammopathy of undetermined significance (no AJCC staging system), and Waldenstrom macroglobulinemia (no AJCC staging system). (from AJCC 8th Ed.)


Adult Burkitt Leukemia

The leukemic counterpart of Burkitt lymphoma occurring in adults.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


ISS Stage II Plasma Cell Myeloma

Plasma cell myeloma with blood levels of beta-2-microglobulin between 3.5 and 5.5 mg/L.


Plasmacytoma anaplastic

A plasmacytoma characterized by the presence of malignant plasma cells with anaplastic features.


Refractory Burkitt Leukemia

Burkitt leukemia resistant to treatment.


Advanced B-Cell Malignant Neoplasm

A B-cell malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Transformed Chronic Lymphocytic Leukemia

The reemergence of chronic lymphocytic leukemia transformed to aggressive diffuse large B-cell lymphoma (Richter's transformation) after a period of remission.


B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

B acute lymphoblastic leukemia with translocations involving tyrosine kinases, or translocations involving either the cytokine receptor-like factor 2 (CRLF2) or rearrangements leading to truncation and activation of the erythropoietin receptor (EPOR). It is associated with an adverse prognosis.


Extramedullary Disease in Plasma Cell Myeloma Involving the Skin

Infiltration of the skin by malignant (clonal) plasma cells in patients with history of plasma cell myeloma.


Stage C Chronic Lymphocytic Leukemia

Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


Cutaneous Chronic Lymphocytic Leukemia

A chronic lymphocytic leukemia that affects the skin.


DS Stage III Plasma Cell Myeloma

Plasma cell myeloma with one or more of the following: 1. Hemoglobin less than 8.5 g/dL. 2. Serum calcium greater than 12.0 mg/dL. 3. More than three lytic bone lesions. 4. High M protein production as shown by: a. IgG greater than 7.0 g/dL. b. IgA greater than 5.0 g/dL. c. Urinary kappa or lamda greater than 12.0 g/24 hours. Estimated myeloma cell mass: greater than 1.2 trillion (1012)/m2 (high burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL. b. Creatinine greater than or equal to 2.0 mg/dL. Serum beta-2-microglobulin has been shown to be a reliable marker for prognosis. Since the great majority of symptomatic myeloma patients are classified as stage III by the Durie/Salmon criteria, this staging system has not proven to be very useful for identifying the patients with intermediate and poor prognosis. Note that the newer International Staging System defines stage III quite differently: Beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months). (PDQ)


DS Stage I Plasma Cell Myeloma

Plasma cell myeloma with all of the following: 1. Hemoglobin greater than 10 g/Dl, 2. Normal serum calcium, 3. Normal bone structure, 4. Low monoclonal (or myeloma) protein (M protein) production as shown by: a. IgG less than 5.0 g/dL, b. IgA less than 3.0 g/dL, c. Urinary kappa or lamda less than 4 g/24 hours. Estimated myeloma cell mass: less than 0.6 trillion (1012)/m2 (low burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note that the newer International Staging System defines stage I quite differently: Beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months). (PDQ)


B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

A precursor B acute lymphoblastic leukemia (B-ALL) which does not have the cytogenetic abnormality t(9;22)(q34;q11.2). Most cases of ALL do not have this translocation.


DS Stage IIIA Plasma Cell Myeloma

Durie/Salmon stage III plasma cell myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


Recurrent B Acute Lymphoblastic Leukemia

The reemergence of B acute lymphoblastic leukemia after a period of remission.


RISS Stage III Plasma Cell Myeloma

Serum beta-2-microglobulin 5.5 mg/L or more and high-risk cytogenetics and/or high LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


Hyperdiploid B Acute Lymphoblastic Leukemia

A B-cell acute leukemia characterized by the presence of lymphoblasts which contain more than 50 and usually less than 66 chromosomes. It is commonly seen in children and rarely in adults. It has a favorable clinical outcome.


B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

The term refers to precursor lymphoid neoplasms which are composed of B-lymphoblasts and characterized by the absence of recurrent genetic abnormalities.


ISS Stage III Plasma Cell Myeloma

Plasma cell myeloma with beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months).  Note that the older Durie/Salmon staging system defines stage III quite differently. (PDQ)


DS Stage IB Plasma Cell Myeloma

Durie/Salmon stage I plasma cell myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


Liver Plasmacytoma

A plasmacytoma that arises in the liver.


Recurrent B-Cell Prolymphocytic Leukemia

The reemergence of a B-cell prolymphocytic leukemia after a period of remission.


Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma

Histologic transformation of an indolent chronic lymphocytic leukemia to an aggressive diffuse large B-cell lymphoma.


Extramedullary Disease in Plasma Cell Myeloma Involving the Kidney

Infiltration of the kidney by malignant (clonal) plasma cells in patients with history of plasma cell myeloma.


Chronic lymphocytic leukemia stage 0

Risk: Low; Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


ISS Stage I Plasma Cell Myeloma

Plasma cell myeloma with beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months).  Note that the older Durie/Salmon staging system defines stage I quite differently. (PDQ)


B-lymphoblastic leukemia lymphoma BCR-ABL1-like

B lymphoblastic leukemia/lymphoma with translocations involving tyrosine kinases, or translocations involving either the cytokine receptor-like factor 2 (CRLF2) or rearrangements leading to truncation and activation of the erythropoietin receptor (EPOR). It is associated with an adverse prognosis.


Plasma Cell Myeloma by DS Stage

A header term that refers to the staging of plasma cell myeloma according to the Durie/Salmon staging system.


Childhood Burkitt Leukemia

The leukemic counterpart of Burkitt lymphoma occurring in children.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


Penile Undifferentiated Pleomorphic Sarcoma

A rare undifferentiated pleomorphic sarcoma that occurs in the penis.


Grade 1 Scrotum Intra-Operative Injury, CTCAE


Non-Neoplastic Vision Disorder

A non-neoplastic disorder that causes a disturbance in normal vision. Representative examples include amblyopia, astigmatism, myopia, and cataracts.


Color Blindness, Inherited

Genetic based difficulty in distinguishing colors.


Advanced Extracranial Malignant Solid Neoplasm

A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


Ciliary Body Adenocarcinoma

An adenocarcinoma arising from the pigmented or non-pigmented ciliary epithelium.


Stage IIB Uveal Melanoma AJCC v7

Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIA Uveal Melanoma AJCC v7

Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0). T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Metastatic Choroid Melanoma

Choroid melanoma that has spread from its primary site to another anatomic site.


Metastatic Malignant Neoplasm in the Uvea

A malignant neoplasm that has spread to the uvea from another anatomic site.


Uveal Melanocytoma

A subtype of ciliary body, iris, and choroidal nevi. It is intensely pigmented and composed of large, plump, polyhedral cells.


Choroid Spindle Cell Type A Melanoma

A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Uveal Melanoma by Gene Expression Profile


Uveal Spindle Cell Type A Melanoma

A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage III Uveal Melanoma AJCC v7

Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC (T4d-e, N0, M0).  T2c: Ciliary body and choroid: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T2d: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T3b: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement. T3c: Ciliary body and choroid: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T4a: Iris: Tumor with extrascleral extension less than or equal to 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 without ciliary body involvement and extraocular extension.  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Uveal Class 2 Melanoma

Gene expression profiling that classifies uveal melanomas into a high-grade group.


Uveal Class 1a Melanoma

Uveal melanoma with low metastatic risk as defined by gene expression profiling.


Ciliary Body Nevus

A benign nevus that arises from the ciliary body. Only a small percentage of cases progress to ciliary body melanoma.


Stage IIIC Uveal Melanoma AJCC v7

Stage IIIC includes: T4d-e, N0, M0.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Uveal Melanoma Metastatic in the Liver

A melanoma that originates from melanocytes of the uveal tract and has spread to the liver.


Refractory Uveal Melanoma

Uveal melanoma that is resistant to treatment.


Choroidal and Ciliary Body Melanoma by AJCC v8 Stage

A term that refers to the staging of choroidal and ciliary body melanoma, following the rules of the TNM AJCC v8 classification system.


Stage IIB Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Choroid Spindle Cell Type B Melanoma

A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Stage IIIB Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0). T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Uveal Class 1b Melanoma

Uveal melanoma with intermediate metastatic risk as defined by gene expression profiling.


Ciliary Body Spindle Cell Type B Melanoma

A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Stage II Uveal Melanoma AJCC v7

Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Choroidal and Ciliary Body Melanoma AJCC v8

Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC: (T4d-e, N0, M0). T2c: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T2d: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T3b: Tumor size category 3 with ciliary body involvement. T3c: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4a: Tumor size category 4 without ciliary body involvement and extraocular extension. T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Stage I Uveal Melanoma AJCC v7

Stage I includes: T1a, N0, M0.  T1a: Iris: Tumor limited to the iris not more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIA Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Stage I Choroidal and Ciliary Body Melanoma AJCC v8

Stage I includes: T1a, N0, M0. T1a: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 8th ed.)


Stage IV Choroidal and Ciliary Body Melanoma AJCC v8

Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c). N1: Regional lymph node metastasis or discrete tumor deposits in the orbit. M0: No distant metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less. M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm. M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.1 cm or more.  (AJCC 8th ed.)


Ciliary Body Spindle Cell Type A Melanoma

A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage IIIB Uveal Melanoma AJCC v7

Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0).  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Iris Mixed Cell Melanoma

A melanoma arising from the iris. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells.


Stage IV Uveal Melanoma AJCC v7

Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c).  N1: Regional lymph node metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less.  M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm.  M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.0 cm or more.  (AJCC 7th ed.)


Benign neoplasm of uveal tract

A non-metastasizing neoplasm that arises from the uvea.


Stage IIIC Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIIC includes: T4d-e, N0, M0. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Metastatic Malignant Neoplasm in the Iris

A malignant neoplasm that has spread to the iris from another anatomic site.


Stage II Choroidal and Ciliary Body Melanoma AJCC v8

Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Uveal Melanoma by AJCC v7 Stage

A term that refers to the staging of uveal melanoma, following the rules of the TNM AJCC v7 classification system.


Uveal Spindle Cell Type B Melanoma

A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Uveal Class 1 Melanoma

Gene expression profiling that classifies uveal melanomas into a low-grade group.


Uveal Nevus

A benign nevus derived from melanocytes of the uveal tract. Only a small percentage of cases progress to uveal melanoma.


Advanced Uveal Melanoma

Uveal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Iris Epithelioid Cell Melanoma

An iris melanoma characterized by the presence of malignant large epithelioid melanocytes.


Metastatic malignant neoplasm to ciliary body

A malignant neoplasm that has spread to the ciliary body from another anatomic site.


Conjunctival keratoacanthomas

A rapidly growing neoplasm that arises from the conjunctiva. It is characterized by a proliferation of squamous cells, acanthosis, keratinization, dysplasia, increased mitotic activity, and a central crater filled with keratinocytes. It is considered a variant of well-differentiated squamous cell carcinoma with distinct clinical behavior.


Conjunctival Spindle Cell Carcinoma

A variant of conjunctival squamous cell carcinoma characterized by the presence of malignant spindle cells and/or pleomorphic cells.


Stage II Fallopian Tube Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Fallopian Tube Cancer AJCC v8

Stage IIA includes: T2a, N0, M0. T2a: Fallopian tube cancer with extension and/or implants on the uterus and/or fallopian tube(s) and/or ovaries. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIB Fallopian Tube Cancer AJCC v8

Stage IIB includes: T2b, N0, M0. T2b: Fallopian tube cancer with tumor extension to and/or implants on other pelvic tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 5 Sepsis, CTCAE

Death


Sepsis, CTCAE

A disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause a rapidly progressing systemic reaction that may lead to shock.


Grade 4 Sepsis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Sepsis, CTCAE

Blood culture positive with signs or symptoms; treatment indicated


Grade 1 Hepatobiliary Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Laryngeal Paraganglioma

An extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to the larynx.  Patients may present with hoarseness and dysphagia.


Finding by Site or System

A term that refers to the classification of a clinical or laboratory finding according to the anatomic site or system that is involved.


Muscle Weakness Right-Sided

A reduction in the strength of the muscles in the right side of the body.


Congenital urinary tract obstruction

An impediment to the flow of urine along the urinary tract, which is present at birth.


Shakes

Unsteadiness or trembling movements of the whole body or a body part.


Right Bundle Branch Block by ECG Finding

An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the right ventricle, manifested by a widened initial portion of the QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration greater than or equal to 120 ms.  An RsR' complex is typically present in leads V1 and V2. (CDISC)


AV Block Second Degree Mobitz Type II by ECG Finding


Jejunum obstruction

Blockage of the normal flow of the small intestinal contents in the jejunum.


Mild Cardiac Valve Stenosis

The cardiac valve orifice is abnormally narrow, to a mild degree. (ACC)


Fallopian tube obstruction

Blockage of the normal flow of the contents in the fallopian tube.


Carpal Spasm

A spasmodic contraction of the muscles of the hands, especially the wrists, such as during alkalosis or tetany. (ACC/AHA)


Pancreatic Duct Stenosis

Narrowing of the lumen of the pancreatic duct.


New daily persistent headache

A bilateral, unremitting headache of mild to moderate intensity that occurs daily and may be associated with photophobia, phonophobia, or mild nausea.


Pregnancy Finding

Symptoms, signs, diagnostic examinations or a test results in a pregnant mother.


Nausea and Vomiting During the First 24 Hours After Chemotherapy

Nausea and vomiting occurring during the first 24 hours following chemotherapy.


Aldosterone Synthase Deficiency Type 2

Aldosterone synthase deficiency characterized by decreased conversion of 18-hydroxycorticosterone to aldosterone.


AV Block Third Degree by ECG Finding

An electrocardiographic finding of complete failure of atrial electrical impulse conduction to the ventricles. This is manifested on the ECG by disassociation of atrial and ventricular rhythms. The atrial rate must be faster than the ventricular rate. (CDISC)


Lumbar Puncture Headache

Headache in erect position, after lumbar puncture; due to lowering of intracranial pressure by leakage of cerebrospinal fluid through the needle tract.


Hypotonic-hyporesponsive episode

Acute onset of unresponsiveness or diminished level of consciousness, associated with loss of muscle tone and pallor or cyanosis, that occurs within 48 hours after childhood immunizations. It is primarily associated with pertussis-containing vaccines administered to children under two years of age.


Subclavian vein stenosis

Narrowing of the lumen of the subclavian vein.


Obstruction of trachea

Blockage of the lumen of the trachea. Causes include secretions, foreign bodies, and tumors.


Damage of Vaginal Mucosa

Injury to vaginal mucosa.


Caries into Dentin

Tooth decay that extends through the enamel into the dentin layer.


Intrapartum Shock

Severe loss of blood pressure leading to inadequate tissue perfusion after the onset of labor but prior to the delivery of the fetus.


Neurogenic shock (disorder)

Shock resulting from neurogenic vasodilation, which can be produced by cerebral trauma or hemorrhage, spinal cord injury, deep general or spinal anesthesia, or toxic central nervous system depression.


Brachial plexus palsy due to birth trauma

Birth injury to the brachial plexus. It results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm, usually in the first week of life. In the majority of cases there is spontaneous recovery.


Pedal Spasm

A spasmodic contraction of the muscles of the feet, especially the ankles, such as during alkalosis or tetany. (ACC/AHA)


Syncope due to Acquired Heart Lesion

A condition in which syncope occurs due to a disease process of the heart with which the patient was not born. (ACC/AHA)


Superficial injury of cornea

Trauma to the corneal epithelium.


Palsy

Muscle weakness or paralysis of neurologic origin.


Shock, Traumatic

Any shock produced by trauma.


Psychogenic tremor

An involuntary, compulsive, repetitive stereotyped movement.


Normal Virilization

The normal development of male secondary sexual characteristics (such as hirsutism, deepening of the voice) in pubertal boys due to testosterone effects.


Insulin Coma

A hypoglycemia-induced comatose state resulting from a large dose of exogenous insulin.


Large Pleural Effusion

A pleural effusion that is typically characterized as more than one liter.


Paroxysmal Supraventricular Tachycardia by ECG Finding

An electrocardiographic finding of episodic supraventricular tachycardia with abrupt onset and termination.


Pregnancy Outcome

Findings observed at the end of a pregnancy.


Maximum ST Segment Depression by ECG Finding

An electrocardiographic finding of the maximum depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Dichorionic Diamniotic Twin Pregnancy

A pregnancy involving two fetuses that each have separate chorions and amniotic sacs.


Jejunal Stenosis

Narrowing of the lumen of jejunum.


Hypotension due to Cardiac Dysfunction

A condition in which there is hypotension because of inadequate pumping function of the heart. (ACC/AHA)


Right Ventricular Hypertrophy by ECG Finding

An electrocardiographic finding suggestive of a hypertrophied right ventricle, characterized by large R wave amplitudes in the right precordial leads and secondary findings of right atrial enlargement, right axis deviation, and typical pattern of ST depression and T wave inversion in the right precordial leads. (CDISC)


Intestinal Stoma Obstruction

A blockage of the intestinal stoma.


Lightheadedness

A feeling of faintness; a reeling sensation. Lightheadedness is medically distinct from dizziness, unsteadiness, and vertigo.


Cyst of thyroid

Abnormal fluid filled sac within the thyroid gland.


Secondary pulmonary hypertension

Pulmonary hypertension that is caused by an underlying condition.


Reproductive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the reproductive system.


Vaginal Perforation

A rupture in the vaginal wall due to traumatic or pathologic processes.


Intraoperative Arterial Injury

Damage to an artery during a surgical procedure.


Pregnancy Status

The pregnancy status of an individual.


High Grade Atrioventricular Block by ECG Finding

An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by two or more consecutive non-conducted P waves. (CDISC)


Ureter Compression

Narrowing of the luminal diameter of one or both ureters due to extrinsic pressure.


COVID-19-Associated Acute Liver Injury

Acute liver injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Foreign body in esophagus

Extraneous material located within the esophagus.


Postpartum Mental or Behavioral Disorder

A maternal mental or behavioral disorder that occurs in the period following the birth of a child and extending up to six weeks after delivery.


Hyperreninemic hypoaldosteronism

Hypoaldosteronism characterized by impaired secretion of aldosterone, despite increased renin activity. This condition may be caused by chronic or critical illness, aldosterone synthase deficiency or other genetic conditions.


Immunodeficiency due to Functional Defects

An indication that an immunodeficiency disorder is caused by the presence of immune cells that are dysfunctional.


Moderate Hepatic Insufficiency

Findings indicating moderate impairment of liver function.


Chronic Maternal Hypertension with Superimposed Preeclampsia

Chronic hypertension in association with preeclampsia.


Reproductive System Hemorrhage

Bleeding originating in the organs and tissue that aid in reproduction.


Monochorionic Monoamniotic Twin Pregnancy

A pregnancy involving two fetuses that share both the chorion and amniotic sac. These twins are invariably identical.


Cardiovascular injury

Trauma to the heart and/or blood vessels.


Urostomy Obstruction

Blockage of the urostomy.


Esophageal injury

Trauma to the esophagus.


Extreme Preterm Birth

Birth when a fetus is less than 28 weeks gestational age.


Female Virilization

The development of male secondary sexual characteristics (such as hirsutism, deepening of the voice, or clitoral enlargement) in girls or adult females.


Vaginal obstruction

Congenital or acquired blockage of the vagina.


Anterior segment ischemia

Compromise of blood supply to the anterior segment of the eye.


Esophageal Anastomotic Leakage

Leakage due to breakdown of an esophageal anastomosis.


Burn of esophagus

Thermal or caustic injury to the esophagus.


Spinal Meningeal Cyst

A cerebrospinal fluid-filled pouch or sac-like protrusion of the arachnoid, dura mater, or nerve root sheath which may contain neural tissue.


Oversedated

A level of sedation that is greater than the intended level.


Eye and Ear Finding

Symptoms, physical examination results, and/or laboratory test results related to the organs of special sense.


Intrapartum Stillbirth

Fetal death greater than or equal to 20 weeks of gestation during labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond.


Visual Halo

Hazy ring around bright lights seen by some patients with refractive error or optical defects, e.g. cataracts, or corneal swelling.


Injury of conjunctiva

Trauma to the conjunctiva of the eye.


Elective Abortion Finding

An abortion performed due to individual choice, in the absence of a harmful medical condition caused by pregnancy.


Leg Injuries

Trauma to the lower extremity, which is confined to the area between the hip and ankle joints.


Injury of colon

Trauma to the colon.


Fetal Heart Finding

An observation of the fetal heart that may or may not be abnormal.


Urethral cyst

A cystic lesion located in the urethra.


Pulmonary vein obstruction

Blockage of the lumen of the pulmonary vein.


Ureteric Perforation

A rupture in the wall of the ureter due to traumatic or pathologic processes.


Minimum ST Segment Depression by ECG Finding

An electrocardiographic finding of the minimum depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Urinary System Finding

Symptoms, physical examination results, and/or laboratory test results related to the urinary system.


Undesired Nerve Stimulation

Unintended reaction in nervous system caused by electrical stimulation.


Carotenosis Cutis

Orange or yellow discoloration of the skin caused by excessive deposits of carotene.


Anticipatory Vomiting

A situation in which an individual vomits prior to a medical treatment, commonly chemotherapy, as part of a conditioned/learned response after having previously experienced nausea and/or vomiting as a direct result of that same (or a similar) treatment.


Pulmonary Artery Wedge Pressure

The pressure measured by wedging a pulmonary catheter with an inflated balloon into a small pulmonary arterial branch.


COVID-19-Associated Acute Gastrointestinal Tract Injury

Acute gastrointestinal tract injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Visceral Artery Ischemia

Decreased blood supply to the small or large intestine due to narrowing or blockage of a visceral (mesenteric) artery. The ischemia results to the damage of the intestinal tissues. It may be chronic, caused by atherosclerosis or acute, secondary to the formation of a thrombus or embolus in the mesenteric arterial lumen. In chronic ischemia, patients present with abdominal pain manifested in a short time after a meal and weight loss. In acute ischemia, patients present with sudden and acute abdominal pain, nausea and vomiting, and blood in the stool.


Obstruction of colon

Blockage of the normal flow of the intestinal contents in the colon.


Caries Restricted to Enamel

Tooth decay that is restricted to the enamel layer.


Adrenal Cyst

A cyst located in the adrenal gland.


Duodenal hemorrhage

Bleeding originating from the duodenum.


Congenital Neurogenic Bladder

Neurogenic bladder, the cause of which is present at birth.


AV Block Second Degree by ECG Finding

An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles. This is manifest on the ECG by regular P waves which intermittently are not followed by QRS complexes. (CDISC)


Borderline hypertension

Blood pressure in the zone between the highest normal level and the level that is considered hypertensive.


Jacksonian Seizure

A partial motor seizure that begins in a single area of the body and progresses to include other areas on the same side of the body.


Oculocardiac Reflex

Slowing or cessation of the heart rate secondary to traction on the extraocular muscle.


Intervertebral Disc Compression or Protrusion

Degenerative, pathological or traumatic changes in the cartilaginous tissue of the spine leading to unwanted compression or protrusion of the disc.


Ventricular Arrhythmia by ECG Finding

An electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles.


Ear Finding

Symptoms, physical examination results, and/or laboratory test results related to the ear.


Alterations in Smell or Taste

A change to taste and/or olfactory perception resulting from disease processes or treatment.


Non-Febrile Seizure

A seizure that is not associated with fever.


Jugular vein injury

Damage to the jugular vein from traumatic or pathologic processes.


Psychosexual dysfunction with inhibited sexual excitement

Recurrent and persistent suppression of sexual excitement during sexual activity.


Impaired Balance

A deficit in equilibrium, which may manifest as unsteady ambulation or inability to maintain an upright position.


Decreased Physical Activity

A reduction in the normal physical activity for an individual.


Gastrointestinal Stoma Stenosis

Narrowing of the lumen of a gastrointestinal stoma.


Cecal Hemorrhage

Bleeding originating in the cecum.


Mean ST Segment Depression by ECG Finding

An electrocardiographic finding of the average depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Arrhythmogenic Syncope

A condition in which syncope occurs due to an arrhythmia. (ACC/AHA)


Melanocortin Pathway Defect

An abnormality in the biochemical pathway involving the melanocortins, a group of peptide hormones associated with anorexogenic signaling in the brain and hypothalamus.


Delayed Orgasm

Sexual dysfunction characterized by a delay in climax.


Intraoperative Ear Injury

Damage to the ear during a surgical procedure.


Endocrine System Signs and Symptoms

Patient complaints, physical findings, laboratory findings referable to the endocrinologic system.


Therapeutic Abortion Finding

An abortion performed on the individual due to a harmful medical condition caused by pregnancy.


Drug-induced hypotension

A condition in which there is hypotension because of the effects of a medication or other substance. (ACC/AHA)


Micropsia

An alteration in visual perception that causes objects to appear smaller than their actual size.


Hormone Imbalance

An abnormal finding indicating that the level of a particular hormone is not within the expected normal values.


Syncope due to Congenital Heart Lesion

A condition in which syncope occurs due to a disease process of the heart with which the patient was born. (ACC/AHA)


Headache due to external compression of head

Headache resulting from pressure applied to the cutaneous nerves of the head.


Acoustic Trauma

Injury to the hearing mechanisms within the inner ear, caused by excessively loud noise.


Cyst of pharynx

A cervical cyst that occurs as a result of the persistence of one or more of the pharyngeal grooves.


Perforation of great vessels

Damage to the venae cavae, pulmonary artery, pulmonary veins or aorta resulting from a full thickness disruption in the integrity of the vessel wall.


Congenital isolated adrenocorticotropic hormone deficiency

Adrenocorticotropic hormone (ACTH) deficiency due to mutation(s) in the TBX19 gene.


Malignant Bowel Obstruction

Obstruction of the bowel by an advanced malignant tumor. It is a complication especially in patients with an advanced abdominal malignant tumor.


Ileal hemorrhage

Bleeding originating from the ileal wall.


Intraoperative Cardiac Injury

Damage to the heart during a surgical procedure.


Embolus

A mass of clotted blood or other formed elements, such as bubbles of air, calcium fragments, etc. brought by the blood from another vessel and forced into a smaller one, thus obstructing the circulation.


Incomplete Bundle Branch Block by ECG Finding

An electrocardiographic finding of partially blocked cardiac electrical impulse conduction along the fibers of one or both bundle branches.


Visual Disturbance

An interference to normal eyesight.


Umbilical Cord Finding

Clinical and laboratory findings about the umbilical cord.


First Trimester Antepartum Hemorrhage

Excessive blood loss within the first trimester but prior to onset of labor.


Injury of liver with open wound into abdominal cavity

Trauma to the liver associated with a break in the tissue that extends into the abdominal cavity.


Aneurysm, Bacterial

An aneurysm caused by an infection.


Endometrioma

A cystic form of endometriosis affecting the ovary.  It may or may not be associated with endometriosis in other areas in the pelvis.


Lamellar laceration of the globe

Traumatic injury to the globe, resulting in a partial thickness wound of the eyewall (cornea and/or sclera). (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Cerebrospinal Fluid Otorrhea

Discharge of cerebrospinal fluid through the ear structures.


In-Hospital Cardiac Arrest

Cardiac arrest which occurs in the hospital setting.


Knee Injuries

Trauma to the knee.


Elbow Injuries

Trauma to the elbow joint.


Intracranial Colloid Cyst

Colloid cysts i.e. cysts filled with gelatinous material, in the central nervous system often are found in the third ventricle. Due to their location, chronic or intermittent hydrocephalus can result. Case reports of sudden death due to acute obstructive hydrocephalus are in the literature. Colloid cysts are benign lesions that should be considered for neurosurgical resection.


Acquired Neurogenic Bladder

Neurogenic bladder, the cause of which is not present at birth.


Migraine-triggered seizure

A seizure triggered by a migraine.


Musculoskeletal Finding

Symptoms, physical examination results, and/or laboratory rest results related to the muscles and bones.


Monochorionic Diamniotic Twin Pregnancy

A pregnancy involving two fetuses that share the same chorion but have separate amniotic sacs.


Kidney perforation

A rupture in the kidney due to traumatic or pathologic processes.


Decreased Uncorrected Visual Acuity

Diminished clarity of vision without optical correction (glasses and/or contacts).


Cardiac Arrest/Arrhythmia Etiology Unknown

An episode of cardiac arrest or arrhythmia where the etiology was unknown. (ACC)


Acquired Urinary Tract Obstruction

A urinary tract obstruction, the cause of which is not present at birth.


Adrenal Androgen Excess

Excessive secretion of the androgen hormones dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione, from the adrenal gland. Clinical manifestations may include virilization.


Complicated Parapneumonic Pleural Effusion

An accumulation of fluid in the pleural space adjacent to an infectious pulmonary process, such as a pneumonia or a lung abscess, and that requires therapeutic drainage.


Mitral perforation

A rupture in the mitral valve tissue due to traumatic or pathologic processes.


Male Reproductive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the male reproductive system.


Injury of esophagus without open wound into thoracic cavity

Trauma to the esophagus without indication of associated damage to the skin and other internal and external tissues.


Hemorrhage of prostate

Bleeding originating from the prostate gland.


Fallopian tube perforation

A rupture of the fallopian tube wall due to tubal pregnancy, or other traumatic or pathologic processes.


Postpartum Complication

Any adverse event that arises in the six week period immediately following the delivery of a fetus.


Fetal virilism

Inappropriate secondary sex characteristics in the neonate usually due to in utero androgen exposure.


Pathologic Laughter

A condition defined by relatively uncontrollable episodes of laughing.


Injury of larynx

Trauma to the larynx.


Injury of anus

Trauma to the anus.


Early Pregnancy Loss

Pregnancy loss before 10th week of gestation with documentation of a confirmed pregnancy.


Endocrine System Finding

Symptoms, physical examination results, and/or laboratory test results related to the endocrine system.


Laceration of the Globe

Full-thickness wound of the eyewall (cornea and/or sclera) caused by a sharp object.


Foreign body in stomach

Extraneous material located within the stomach.


Arteriovenous fistula aneurysm

A bulge in a weakened vessel wall segment of an arteriovenous fistula.


Insulin Shock

A hypoglycemic reaction to overdosage of insulin, a skipped meal, or strenuous exercise in an insulin-dependent diabetic.


Coma Greater than 24 Hours

An indication that coma has lasted more than 24 hours.


Proximal Left Anterior Descending Coronary Artery Stenosis

A narrowing of the proximal portion of the left main coronary artery, usually considered significant if the stenosis is 70% or greater.


Fine corneal edema

Corneal edema of inflammatory origin associated with contact lens wear and morphologically characterized by presence of epithelial microcysts. Microcysts are small (typically 10-50 microns in diameter), clear, irregularly shaped high refractive inclusions that form in the basal layers of the epithelium and move towards the anterior surface of the cornea, surrounding epithelial haze. The cause of microcytic edema is related to the physical presence of contact lenses and possibly a mechanical effect of lens wear.


Penetrating open globe injury

Full thickness wound of the eyewall (cornea and/or sclera) caused by the entry of a sharp object into the eye. (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Macropsia

An alteration in visual perception that causes objects to appear larger than their actual size.


Erythema of the Oropharyngeal Mucosa

Erythema of the mucus membranes lining the part of the pharynx located between the soft palate and the upper portion of the epiglottis.


Tracheostomy Site Bleeding

Bleeding from the tracheostomy site.


left main coronary artery stenosis

Percent luminal narrowing of the left main coronary artery, at the point of maximal stenosis of the left main coronary artery.


Eye muscle weakness

A reduction in the strength of the eye muscles.


Urinary Tract Stenosis

An intrinsic narrowing of a lumen of the urinary tract.


Sensory Change

An alteration in the perceptual senses an individual.


Ileal Obstruction

Blockage of the normal flow of the small intestinal contents in the ileum.


Ventricular Tachycardia/Ventricular Fibrillation Arrest

A cardiac arrest attributed to ventricular tachycardia or ventricular fibrillation.


AV Block Second Degree Mobitz Type I by ECG Finding

An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a progressively lengthening PR interval prior to the block of an atrial impulse. (CDISC)


Familial Male Precocious Puberty

Early development of isosexual secondary characteristics in boys, due to autosomal dominant mutations in the LHCGR gene.


Pigmentary Change in Skin

Abnormal skin pigmentation.


Injury to Superior Vena Cava

Damage to the superior vena cava from traumatic or pathologic processes.


Antepartum Uterine Rupture

An acute symptomatic tearing of the uterine wall prior to the onset of labor.


Dissecting Abdominal Aortic Aneurysm

A dissecting aneurysm in the portion of the descending aortic wall that is within the abdomen.


Chronic peritoneal effusion (disorder)

Persistent or recurring accumulation of fluid in the peritoneal cavity.


Vaginal Discharge

Normal or abnormal secretions from the vagina. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Causes of abnormal vaginal discharge include infectious agents (e.g., Neisseria gonorrhea, Chlamydia trachomatis, Trichomonas, and Candida albicans), the presence of foreign bodies, and cervical or vaginal cancer.


Watering Eyes

Tearing eyes; a condition caused either by tear overproduction or impaired drainage of the tear duct. Causes of tear overproduction include eye irritation (e.g., eye infection, foreign body in the eye), headache, pain reaction, allergies, sinusitis, and injury to the eye.


Erb-Duchenne Paralysis

Weakness or paralysis of muscles in the arm due to damage in the upper brachial plexus.


Spontaneous Intestinal Perforation

A focal intestinal perforation without a definite cause, commonly located in the terminal ileum, lacking the transmural inflammation and/or pneumatosis typically seen in necrotizing enterocolitis.


Cardioinhibitory Syncope

A condition in which neurally-mediated syncope occurs in which the blood pressure falls and heart rate falls. (ACC/AHA)


Nail Changes

Alteration of the normal characteristics of the fingernails or toenails. Examples include thickening, thinning, deformity, and separation from the nail bed.


Zenker Diverticulum

A diverticulum of the posterior pharyngeal wall opening, which is located just posterior the cricoid cartilage, between the inferior pharyngeal constrictor and the cricopharyngeus muscles.


Visual Change

An alteration in the visual system of an individual.


Foot Or Leg Hypoesthesia

Consisting of abnormally decreased sensitivity, particularly to touch in the foot or leg.


Hormone Resistance

A finding indicating decreased tissue sensitivity to a hormone.


Finger Injuries

Trauma to one of the digits on the hand.


Gastrointestinal Adhesion

A fibrous connection of tissue that joins together normally separate gastrointestinal regions.


Urostomy perforation

A perforation in the anatomic parts which are used in the construction of a urostomy.


Heart Block by ECG Finding

An electrocardiographic finding of blocked cardiac electrical impulses along the fibers normally responsible for impulse conduction.


Unilateral Numbness

A loss of the sensation of feeling on one side of the body.


Perforating open globe injury

Open globe injury with both entrance and exit wounds in the eyewall (cornea and/or sclera) caused by the same object.


Cushing Triad

A group of signs that often occurs in response to increased intracranial pressure: hypertension, bradycardia, and irregular breathing.


Flasher

The perception of sudden or brief bursts (flashes) of light.


Refractory Esophageal Anastomotic Stricture

Esophageal anastomotic stricture that remains narrowed despite repeated therapeutic dilations.


Acquired Adrenocorticotropic Hormone Deficiency

Adrenocorticotropic hormone (ACTH) deficiency, the cause of which is not present at birth.


Hemorrhage of digestive system

Bleeding originating from any part of the digestive system.


Recurrent Esophageal Anastomotic Stricture

Recurrence of an esophageal anastomotic stricture following therapeutic dilation.


Syncope due to Migraine

A condition in which syncope occurs associated with the occurrence of cerebral vasospasm. (ACC/AHA)


Caries, Region Unknown

Tooth decay of an unspecified location.


Vasoconstriction

Vasoconstriction involves narrowing of a blood vessel lumen due to smooth muscle contraction in the vessel wall and leads to decreased blood flow.


Connective and Soft Tissue Injury

Damage inflicted on the soft tissues and their supporting structures as the direct or indirect result of an external force, with or without disruption of structural continuity.


Motor Manifestations

The presence of an alteration in the ability to move one's body or any body parts in accordance with one's intent.


Stricture of ureter

Narrowing of the lumen of the ureter.


Ureterovesical Obstruction

Blockage of the opening between the ureter and the bladder resulting in the reduction or prevention of the urine flow from the ureter to the bladder.


Supraventricular Arrhythmia by ECG Finding

An electrocardiographic finding of an arrhythmia originating in the atrium, AV node or AV junction.


Electrocardiographic Finding

Graphic representation and categorization of the electrical vectors produced by the depolarization and repolarization of myocardial tissue.


Unspecified antepartum hypertension

High blood pressure in the period of time preceding labor and delivery.


Primary Cough Headache

Headache triggered by coughing or straining in the absence of an intracranial disorder.


COVID-19-Associated Acute Kidney Injury

Acute kidney injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Bronchial Stricture

Narrowing of a bronchial tube.


Digestive System Signs and Symptoms

Signs and symptoms associated with disturbances within the digestive system, which includes the stomach, intestines and all associated organs that aid in digestion.


Intestinal Stoma Site Hemorrhage

A finding of blood leakage from the intestinal stoma.


Vaginal Cyst

A cyst located in the vagina.


Conjunctival Ecchymosis

Bleeding between the conjunctiva and episclera in the absence of discharge or inflammation.


Jejunal hemorrhage

Bleeding originating from the jejunal wall.


Recurrent Large Pleural Effusion

The reemergence of a large pleural effusion after a period of remission.


Uncomplicated hypertension

A condition of high blood pressure without resulting clinical disorders.


Vascular stenosis

Narrowing of the lumen of an artery or vein.


Delayed Nausea and Vomiting

Nausea and vomiting occurring more than 24 hours following chemotherapy.


Cervical Spine Joint Range of Motion Decreased

Decreased flexibility of a cervical spine joint.


Phosphene Visualization

An objective visual sensation that appears with the eyes closed and in the absence of visual light.


Testicular Cyst

A cystic lesion located in the testes.


Valvular stenosis

Narrowing of the opening of one or more of the four valves of the heart.


Inferior vena cava stenosis

Abnormal narrowing of the lumen of the inferior vena cava.


Coronary artery perforation

A dissection that extends through the full thickness of the coronary arterial wall. (ACC)


Page kidney

Hypertension resulting from activation of the renin-angiotensin system in response to prolonged compression of the renal parenchyma and blood vessels.


Decreased Visual Acuity with Current Correction

Diminished clarity of vision with current correction (glasses and/or contacts).


Congenital obstruction of ureteropelvic junction

Complete or partial blockage of the ureter at the point where it enters the kidney that is present at birth.


Late Fetal Death

Death of a fetus at 16 weeks, 0 days to 19 weeks, 6 days of gestation.


Phantogeusia

A lingering, usually unpleasant, taste without the associated stimulus.


Vas deferens stenosis

Narrowing of the lumen of the vas deferens.


Breastfeeding Jaundice

Yellow coloring of skin, mucous membranes and eyes in an otherwise healthy breast-fed newborn due to insufficient intake of maternally-expressed milk. It commonly appears four to seven days after birth.


Neck sprain

Stretching or tearing of ligaments in the neck.


Radiation-induced stricture of esophagus


Laceration of liver

A cut or tear in the liver.


Incomplete Left Bundle Branch Block by ECG Finding

An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the left ventricle, manifest as a widened initial portion of the QRS complex in leads V5, V6, I and aVL and with QRS duration less than 120 ms. (CDISC)


Left Main Coronary Artery Stenosis, Percentage

The percentage of narrowing of the left main coronary artery.


Extraocular Muscle Paresis

A slight or incomplete paralysis of an extraocular muscle.


Laryngeal Hemorrhage

Bleeding originating from the larynx.


Loss of Vision

A condition in which the ability to see is impaired.


Open globe injury

A full thickness wound of the eyewall (sclera and cornea). (Birmingham Eye Trauma Terminology System (BETTS))


Primary Exertional Headache

Headache triggered by exercise.


Pregnancy Related Skin Change

Alterations in the skin's appearance during pregnancy due to hormonal level changes.


Numbness

A loss of the sensation of feeling in an area of the body.


Active Caries

Tooth decay that is increasing in size or scope.


Hemorrhage of spermatic cord

Bleeding originating from the spermatic cord.


Chemical burns of eye

Injury to the eye secondary to a chemical substance.


Diastolic hypertension

Hypertension characterized diastolic blood pressure greater than 90 mmHg on two occasions.


Sternocleidomastoid Injury Related to Birth

Disruption of the sternocleidomastoid muscle incurred during delivery.


Aldosterone Synthase Deficiency Type 1

Aldosterone synthase deficiency characterized by decreased conversion of corticosterone to 18-hydroxycorticosterone.


Vas deferens obstruction

Blockage of the normal flow of the sperm in the vas deferens.


Bowel Burn

A thermal, chemical or radiation injury to the bowels.


injury of rectum with open wound into cavity

Trauma to the rectum associated with a break in the tissue that extends into the rectum.


Ligament injury

An injury to any of the fibrous bands of tissue that comprise an articulation (joint).


Brachial Plexus Palsy

An injury that results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm. In the majority of cases there is spontaneous recovery.


Bone injury

Trauma to bone.


Endoleak

Persistent blood flow/pressure in the aneurysm sac following an endovascular aneurysm repair (EVAR) procedure.


Blacking Out

A temporary loss of consciousness or a temporary state of altered consciousness that results in memory loss.


Bradycardia Arrest

Cardiac arrest that was a result of bradycardia.


Connective and Soft Tissue Finding

Symptoms, physical examination results, and/or laboratory test results related to the connective and soft tissue.


Fetal Hypoxemia

Abnormally low arterial blood oxygen concentration in a fetus.


Muscular Tic

An involuntary, compulsive, repetitive stereotyped movement, usually of the face or shoulders.


Unspecified renovascular hypertension

High blood pressure caused by renal artery stenosis.


Nervous System Finding

Symptoms, physical examination results, and/or laboratory test results related to the nervous system.


Early Fetal Death

Death of a fetus at 10 weeks, 0 days to 15 weeks, 6 days of gestation.


Neurogenic Orthostatic Hypotension

Orthostatic hypotension due to autonomic dysfunction. Primary neurogenic orthostatic hypotension (nOH) may be associated with disorders such as Parkinson disease (PD) and multiple system atrophy (MSA) whereas secondary nOH may be seen in peripheral neuropathies.


Delayed Postpartum Hemorrhage

Excessive blood loss between 24 hours after delivery through four weeks that requires intervention.


Tingling

A sensation as of repetitive pin pricks, caused by cold or by striking a nerve, or as a result of various diseases of the central or peripheral nervous system.


Abnormal Sensation of Face and Limbs

Sensations of the face and limbs that are not considered normal.


Small Intestinal Anastomotic Leakage

Leakage due to breakdown of a small intestinal anastomosis.


Chronic Maternal Hypertension

Hypertension that predates pregnancy.


Junctional premature complex (disorder)

An electrocardiographic finding of an ectopic impulse originating in the AV junction presenting as a QRS complex of supraventricular origin which is not preceded by a P wave. (CDISC)


Immunodeficiency due to Quantitative Defects

An indication that an immunodeficiency disorder is caused by a partial or complete loss of one or more of the hematopoietic cell lineages that are involved in host defense.


Injury of duodenum with open wound into abdominal cavity

Trauma to the duodenum associated with a break in the tissue that extends into the abdominal cavity.


Drug-induced Syncope

A condition in which syncope occurs due to the ingestion or administration of a chemical substance. (ACC/AHA)


Fetal Presentation

The first part of the fetus that is visible at the cervical opening during delivery.


Hand Injuries

Trauma to the hand.


Bursa injury

Trauma to a bursa.


Abnormal Gait and Coordination

Gait and coordination movements that are not considered normal.


Postoperative Hypertension

A transient increase in blood pressure following a surgical procedure.


Fecal Occult Blood

Blood in the feces that is not visibly apparent.


Endobronchial Obstruction

Partial or complete blockage of the bronchial lumen by a pathological process that occurs within the bronchus.


Mottling

Irregularly shaped, patchy discolorations in the skin.


Third Trimester Antepartum Hemorrhage

Excessive blood loss within the third trimester but prior to onset of labor.


Iris pigment epithelial cyst

A cystic lesion arising from the iris pigment epithelium at the posterior iris surface. (WHO 2018)


Abortion complete

Expulsion of all the products of conception following spontaneous, medical or operative pregnancy termination.


Induced Abortion Finding

Abortion brought on intentionally.


Corneal burn

Chemical or radiant injury to the cornea.


Arteriovenous graft aneurysm

A bulge in a weakened wall segment of an arteriovenous graft.


Spermatic cord obstruction

Blockage of the normal flow of the contents of the spermatic cord.


Systolic Hypertension

Abnormally high systolic blood pressure.


Hematosalpinx

The presence of blood in a fallopian tube.


Associated Pulmonary Arterial Hypertension

Pulmonary hypertension that results from another disorder (e.g., connective tissue disorder).


ST Segment Abnormality by ECG Finding

An electrocardiographic finding of ST segment elevation or depression.


Ovarian Hyperandrogenism

Increased production of androgens by the ovaries.


Exit Block by ECG Finding

An electrocardiographic finding in which impaired conduction or automaticity within the sinus node results in the failure of impulse transmission from the sinoatrial node. This is manifested as dropped P waves during sinus rhythm. (CDISC)


Intraoperative Venous Injury

Damage to a vein during a surgical procedure.


Severe Cardiac Valve Stenosis

The cardiac valve orifice is abnormally narrow, to a severe degree. (ACC)


Hemorrhage of testis

Bleeding originating from the testis.


Resuscitated Cardiac Arrest Event

Cardiac arrest that is reversed, usually by CPR and/or defibrillation or cardioversion, or cardiac pacing.


Disturbance of Skin Sensation

Disruption of the normal functioning of the sensory nerves in the skin.


Early Stillbirth

Delivery of a dead fetus greater than 22 weeks but less than 28 weeks gestational age, and/or whose birth weight is greater than 500 grams but less than 1,000 grams.


Antibiotic-associated diarrhea

Diarrhea that is associated with current or recent antibiotic use.


Intraoperative Ocular Injury

Damage to the eye during a surgical procedure.


Neonatal melena

Abnormally dark tarry feces containing blood, usually due to gastrointestinal bleeding or swallowed maternal blood in neonates.


Congenital jejunal stenosis

Narrowing of the lumen of the jejunum that is present at birth.


Opioid-Induced Constipation

Constipation that results from, or follows, treatment with an opioid or opioid-containing medication.


Paroxysmal atrioventricular block

An electrocardiographic finding of the sudden onset of transient AV block, which is often associated with preexisting conduction disorders. (CDISC)


Arm Or Hand Hypoesthesia

Consisting of abnormally decreased sensitivity, particularly to touch in the arm or hand.


Congenital ileal stenosis

Narrowing of the lumen of the ileum that is present at birth.


Surgical Shock

Hypoperfusion of body tissues occurring during or after a surgical procedure, and resulting in cellular injury and vital organ dysfunction.


Central Nervous System Signs and Symptoms

Signs and symptoms associated with disturbances within the central nervous system, which includes the brain, spinal cord and meninges.


Cardiac perforation

The presence of an acquired hole in the heart. Cardiac perforation may or may not be symptomatic and may or may not be self sealing. (ACC)


Female Reproductive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the female reproductive system.


Sprain

A stretching or tearing of a ligament.


Intraoperative Digestive System Injury

Damage to any part of the digestive system during a surgical procedure.


Proprioceptive Hallucination

Perception of the orientation of the body in space, manifesting as a sensation of floating, flying, in the absence of a corresponding stimulus.


Syncope with Exertion

A condition in which syncope occurs either during or after physical activity. (ACC/AHA)


Vasodepressor Syncope

A condition in which neurally-mediated syncope occurs in which the blood pressure falls and the heart rate increases. (ACC/AHA)


Cardiac Arrest Prior to Percutaneous Coronary Intervention

Cardiac arrest which occurs before a percutaneous coronary intervention can take place. (ACC)


Stenosis of bladder neck

Narrowing or stricture of the bladder neck.


Neonatal Vaginal Discharge

Secretions which may be thin or tenacious, mucoid or glairy, grayish or milky, occasionally blood tinged, that originate in the vagina and are a consequence of the residual influence of maternal estrogen.


Vasovagal Reaction

Sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the activity of the vagus nerve. It may be triggered by emotions of fear or pain or gastrointestinal upset and may be relieved by lying down while keeping the legs elevated.


Illegal Abortion

Unlawfully induced expulsion of all products of conception.


Postcoital bleeding

Non-menstrual bleeding that occurs during or after sexual intercourse.


Hemorrhage of vas deferens

Bleeding originating from the vas deferens.


Immediate Postpartum Hemorrhage

Cumulative blood loss of greater than or equal to 1000 ML or blood loss accompanied by signs or symptoms of hypovolemia within 24 hours following the birth process (includes intrapartum loss). (reVITALize)


Infectious Hidradenitis

Hidradenitis that is caused by an infectious agent, usually a bacterium.


Gastric Stenosis

Narrowing of the lumen of the stomach.


Skin Type

A distinctive characteristic of the skin marked by the amount of sebum secreted by sebaceous glands.


Binocular Diplopia

Perception of two images secondary to misalignment of the eyes.


Gum injury

Trauma to the gingiva


Atrioventricular Reentrant Tachycardia by ECG Finding

An electrocardiographic finding of a regular supraventricular tachycardia which utilizes an atrioventricular bypass tract as its retrograde limb (orthodromic tachycardia) or as its antegrade limb (antidromic tachycardia). QRS complexes during sinus rhythm may show preexcitation. During orthodromic tachycardia the preexcitation is not present and a retrograde P wave may appear after the QRS complex. During antidromic tachycardia the QRS complex is preexcited. (CDISC)


Esophageal anastomotic stricture

Luminal narrowing at the site of surgical resection and reconstruction of the esophagus.


Labial Fusion

Usually found in girls between 6 months and 6 years of age, this condition occurs wherein the labia grow together instead of as 2 separate folds, thereby blocking the opening of the vagina. It is caused by conditions such as repeated diaper rash, urine and stool infections, and sexual abuse. The condition often spontaneously corrects or responds to the application of estrogen cream.


Fecal Urgency

A continual or recurrent inclination to evacuate the bowels.


Eye foreign bodies

External material inside the eyeball.


Rathke Cleft Cysts

Rathke's pouch cysts are rarely symptomatic in the first two decades of life though they may produce symptoms in the third and fourth decades of life.  When the cysts do present in the first decades of life, the symptoms are generally associated with diabetes insipidus or other conditions related to hypopituitarism.


COVID-19-Associated Acute Digestive System Injury

Acute digestive system injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Hypertension secondary to endocrine disorder

A condition of high blood pressure occurring in association with diseases of the endocrine glands.


In Utero Bowel Perforation

Bowel perforation in utero that may result in meconium peritonitis.


Benign congenital hypotonia

Mild hypotonia that usually appears early in infancy and has a favorable outcome. It is not a manifestation of another disorder that may cause hypotonia (e.g., cerebral palsy or muscular dystrophy).


Malignant biliary obstruction

Blockage in the biliary tract caused by a malignant neoplasm.


Aortic Injury

Damage to the aorta from traumatic or pathologic processes.


Secondary caries

A carious lesion adjacent to an existing restoration.


Reflex

An automatic instinctive unlearned reaction to a stimulus.


Focal Motor Weakness

Impairments of brain function, the nerve or spinal cord that affect a specific region of the body.


Psychogenic syncope

A condition in which syncope occurs due to a conversion disorder. (ACC/AHA)


Conjunctival cyst

Abnormal fluid filled sac within the conjunctiva.


Urostomy Site Bleeding

Hemorrhage from the urostomy site.


Perforation of jejunum

A rupture in the jejunal wall due to traumatic or pathologic processes.


Prostatic perforation

An opening in the prostate gland due to traumatic or pathologic processes.


Spontaneous Preterm Birth

Preterm birth from 20 weeks to 36 weeks, 6 days of gestation associated with one of the following: classic preterm labor or preterm premature rupture of membranes.


Peritumoral Brain Edema

An intracranial edema that develops around a tumor in the meninges or brain.


Heat Sensation

An internal feeling of being warmer without a concomitant change in the ambient environment. (ACC/AHA)


Varicose veins of lower extremity

An abnormally dilated superficial vein in the legs.


Injury of cardiac valve

An event causes abnormal valve function; this is usually a tear in leaflet or chordae tendinae and manifests as a new regurgitant. (ACC)


Muscle Weakness Trunk

A reduction in the strength of the trunk muscles.


Fallopian tube stenosis

Narrowing of the lumen of the fallopian tube.


Blood Pressure Finding

A test result that reports the diastolic and systolic pressure of the blood.


Syncope with High Risk Cardiac Characteristics

A sudden loss of consciousness with loss of postural tone not related to anesthesia with high risk characteristics. High risk characteristics include non-ischemic dilated cardiomyopathy, or ischemic heart disease with significant ventricular dysfunction, hypertrophic cardiomyopathy, Brugada Syndrome, or Long QT Syndrome. (ACC)


COVID-19-Associated Acute Intestinal Injury

Acute intestinal injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Berry Aneurysm

A small cerebral artery aneurysm, characterized by a saccular appearance, that typically forms at the junction of vessels in the circle of Willis.


Cisplatin-Induced Tinnitus

Tinnitus that is caused by exposure to cisplatin.


Uterine Cervical Stenosis

Congenital or acquired narrowing of the lumen of the uterine cervix.


Rectal Anastomotic Leakage

Leakage due to breakdown of a rectal anastomosis.


Grade 3 Seizure, ASTCT ICANS

Any clinical seizure focal or generalized that resolves rapidly or nonconvulsive seizures on EEG that resolve with intervention, as defined by the American Society for Transplantation and Cellular Therapy (ASTCT) and the Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) Consensus Grading for Adults.


Congenital obstruction of ureteral orifice

Complete or partial blockage of the ureter at the point where it enters the bladder that is present at birth.


Pancreatic Anastomotic Leakage

Leakage due to breakdown of a pancreatic anastomosis.


Digestive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the digestive system.


Muscle Weakness Left-Sided

A reduction in the strength of the muscles in the left side of the body.


Ventricular Tachycardia by ECG Finding

An electrocardiographic finding of three or more consecutive complexes of ventricular organ with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC)


Varicose veins of lower extremities with inflammation

Inflammation of enlarged and tortuous veins in the hip, thigh, leg and/or foot.


Blood Clot

An aggregation of blood factors, primarily platelets and fibrin with entrapment of cellular elements, frequently causing vascular obstruction at the point of its formation.


Spermatic Cord Perforation

An opening in the wall of the spermatic cord.


Hemorrhage in bile duct

Bleeding originating from the bile duct.


Closed injury of eyeball

Traumatic injury to one or more intraocular structures without full thickness wound of the eyewall (sclera and cornea). (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Hemorrhage of pancreas

Bleeding originating from the pancreas.


Cardiac Arrest Requiring Cardiopulmonary Resuscitation

Cardiac arrest that is treated by CPR and/or defibrillation, regardless of outcome.


Integumentary System Finding

Symptoms, physical examination results, and/or laboratory test results related to the integumentary system.


Diplopia, Unilateral

Perception of more than one image when viewing with one eye.


Pharyngeal Stenosis

Narrowing of the pharyngeal airway.


Neutrophilic Eccrine Hidradenitis

Painful red or pink edematous nodules most commonly found on the palmar and/or plantar regions.


Injury of nose

Trauma to the nose.


Traumatic chylothorax

Accumulation of lymph fluid in the pleural cavity as a result of thoracic trauma.


Jaundice, Hemolytic

Jaundice occurring as a result of red blood cell rupture.


Indicated Preterm Birth

Preterm birth from 20 weeks to 36 weeks, and 6 days of gestation that is necessitated by the medical condition of the mother or fetus.


Arteriovenous graft stenosis

Narrowing of the lumen of an arteriovenous graft.


Acquired supradiaphragmatic diverticulum of esophagus


Testicular perforation

A rupture through the testicular tissue.


Arrhythmia by ECG Finding

An arrhythmia that is detected on an electrocardiograph.


Late Pregnancy Loss

The loss of a pregnancy between 13 and 22 weeks.


Carious Dentin

Tooth decay that has invaded the dentin, creating dentin that is partially demineralized and containing mineral crystals in the tubules.


Myocardial Contusions

A bruise to the heart.


Spermatic cord stenosis

Narrowing or stricture of the spermatic cord.


Faceplant

A syncopal event in which there is no attempt to protect oneself from the effects of the fall.


Acral Erythema

Reddening of the palmar and plantar regions of the body with occasional involvement of the distal extremities.


Large Intestinal Anastomotic Leakage

Leakage due to breakdown of a large intestinal anastomosis.