tyrosine-protein phosphatase non-receptor type 1 phosphorylated 1 (human)

A tyrosine-protein phosphatase non-receptor type 1 (human) that has been phosphorylated at Tyr-66. UniProtKB:P18031, Tyr-66, MOD:00048.


ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform h2 (human)

An ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13822-2.


citramalyl-CoA lyase, mitochondrial

A protein that is a translation product of the human CLYBL gene or a 1:1 ortholog thereof.


citramalyl-CoA lyase, mitochondrial isoform h1 (human)

A citramalyl-CoA lyase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N0X4-1.


citramalyl-CoA lyase, mitochondrial isoform h2 (human)

A citramalyl-CoA lyase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N0X4-2.


phospholipid-transporting ATPase ABCA7 isoform h1 (human)

A phospholipid-transporting ATPase ABCA7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IZY2-1.


ornithine decarboxylase antizyme 2 isoform 1 (human)

An ornithine decarboxylase antizyme 2 isoform 1 that is encoded in the genome of human.


ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1 (human)

A ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1 that is encoded in the genome of human.


calcium-dependent secretion activator 2 isoform h1 (human)

A calcium-dependent secretion activator 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86UW7-1.


ectonucleoside triphosphate diphosphohydrolase 3 isoform h2 (human)

An ectonucleoside triphosphate diphosphohydrolase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75355-2.


cadherin-5 N-glycosylated 2 (human)

A cadherin-5 (human) that has been N-glycosylated at the residue equivalent to Asn-442 of the amino acid sequence represented by UniProtKB:P33151-1, in which the glycan composition is represented by GlyTouCan:G80475RE. Example: UniProtKB:P33151-1, Asn-442, MOD:00160~GNO:G80475RE.


cAMP-dependent protein kinase inhibitor gamma isoform 1 (human)

A cAMP-dependent protein kinase inhibitor gamma isoform 1 that is encoded in the genome of human.


Lung Carcinoma Metastatic in the Bone

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

A carcinoma that arises from the lung and has metastasized to the bone.


syndromic disease

A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition.


pseudopseudohypoparathyroidism

A disease characterized by a constellation of clinical features collectively termed Albright hereditary osteodystrophy (AHO) but no evidence of resistance to parathyroid hormone (PTH), which is seen in other forms of pseudohypoparathyroidism (PHP).


autoinflammatory syndrome

A group of disorders of the innate immune system characterized by attacks of seemingly unprovoked inflammation without significant levels of either autoantibodies or autoreactive T cells more characteristic of autoimmune disease.


Felty syndrome

Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.


pseudohypoparathyroidism type 1A

A type of pseudohypoparathyroidism (PHP) characterized by renal resistance to parathyroid hormone (PTH), resulting in hypocalcemia, hyperphosphatemia, and elevated PTH; resistance to other hormones including thydroid stimulating hormone (TSH), gonadotropins and growth-hormone-releasing hormone (GHRH); and a constellation of clinical features known as Albright hereditary osteodystrophy (AHO).


Hereditary paraganglioma-pheochromocytomas (PGL/PCC) are rare neuroendocrine tumors represented by paragangliomas (occurring in any paraganglia from the skull base to the pelvic floor) and pheochromocytomas (adrenal medullary paragangliomas).


neoplastic syndrome

A broad classification for disorders in which the development of neoplasms typically occur in association with a characteristic set of signs or symptoms. These disorders may be inherited or acquired.


Rett syndrome, congenital variant

An autosomal dominant condition caused by mutation(s) in the FOXG1 gene, encoding forkhead box protein G1. It is the most severe form of Rett syndrome, and typically manifests within the first three months of life.


Prader-Willi syndrome

Prader-Willi syndrome is a rare genetic disorder characterized by hypothalamic-pituitary abnormalities with severe hypotonia during the neonatal period and first two years of life and the onset of hyperphagia with a risk of morbid obesity during infancy and adulthood, learning difficulties and behavioral problems or severe psychiatric problems.


Crigler-Najjar syndrome

Crigler-Najjar syndrome (CNS) is a hereditary disorder of bilirubin metabolism characterized by unconjugated hyperbilirubinemia due to a hepatic deficit of bilirubin glucuronosyltransferase (GT) activity. Two types have been described, CNS types 1 and 2. CNS1 is characterized by a complete deficit of the enzyme and is unaffected by phenobarbital induction therapy, whereas the enzymatic deficit is partial and responds to phenobarbital in CNS2.


Guillain-Barre syndrome

A spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients. GBS is clinically heterogeneous and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS) and some other regional variants.


WAGR syndrome

WAGR syndrome (Wilms tumor - aniridia - genitourinary anomalies - intellectual disability mental retardation) is a rare genetic disorder characterized by an unusual complex of congenital developmental abnormalities with intellectual disability, and an increased risk of developing Wilms tumor.


telomere syndrome

Accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased telomere lengths.


mucopolysaccharidosis type 4

Mucopolysaccharidosis type IV (MPS IV) is a lysosomal storage disease belonging to the group of mucopolysaccharidoses, and characterised by spondylo-epiphyso-metaphyseal dysplasia. It exists in two forms, A and B.


Smith-Magenis syndrome

Smith-Magenis syndrome (SMS) is a complex genetic disorder characterized by variable intellectual deficit, sleep disturbance, craniofacial and skeletal anomalies, psychiatric disorders, and speech and motor delay.


Wilms tumor, aniridia, genitourinary anomalies, intellectual disability, and obesity syndrome

A sub-phenotype of WAGR that includes obesity, and is associated with mutation(s) in the BDNF gene.


abdominal obesity-metabolic syndrome

A combination of medical conditions that when present, increase the risk of heart attack, stroke, and diabetes mellitus. It includes the following medical conditions: increased blood pressure, central obesity, dyslipidemia, impaired glucose tolerance, and insulin resistance.


motor developmental delay due to 14q32.2 paternally expressed gene defect

A cause of obesity that results from inheritance of two copies of chromosome 14 from the mother, and no copy of chromosome 14 from the father.


rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome

A very rare disorder that appears after the first year and a half of life in previously healthy children. It is characterized by rapid-onset weight gain, hypothalamic dysfunction, breathing abnormalities, and autonomic system dysregulation. The hypothalamic dysfunction manifestations include inability to maintain normal water balance, high prolactin levels, low thyroid, low cortisol, and early or late puberty. The breathing abnormalities include sleep apnea and alveolar hypoventilation, requiring ventilation support. The autonomic system dysregulation includes eye abnormalities, intestinal abnormalities, temperature dysregulation, and low heart rhythm. This disorder requires early recognition because it may lead to cardiorespiratory arrest. Up to 40% of the patients develop tumors of neural crest origin.


hereditary neoplastic syndrome

The inherited predisposition toward getting a tumor.


Alstrom syndrome

A multisystemic disorder characterized by cone-rod dystrophy, hearing loss, obesity, insulin resistance and hyperinsulinemia, type 2 diabetes mellitus, dilated cardiomyopathy (DCM), and progressive hepatic and renal dysfunction.


Carpenter syndrome

An extremely rare autosomal recessive syndrome characterized by premature closure of cranial sutures leading to cone-shaped head, fusion of the digits, and the presence of more digits than normal. It may be associated with heart defects, single horseshoe-shaped kidney, short stature, undescended testes, and mild mental retardation.


triploidy

Triploidy is a chromosome abnormality that occurs when there is an extra set of chromosomes present in each cell. Most pregnancies affected by triploidy are lost through early miscarriage. However, reports exist of some affected babies living up to five months. Those that survive are often mosaic. The signs and symptoms associated with triploidy vary but may include a variety of birth defects and an unusually small size. This condition does not run in families and is not associated with maternal or paternal age. Treatment is based on the signs and symptoms present in each person.


Wolfram syndrome

Wolfram syndrome (WS) also known as DIDMOAD, is a neurodegenerative disorder characterized by type I diabetes mellitus (DM), diabetes insipidus (DI), sensorineural deafness (D), bilateral optical atrophy (OA) and neurological signs. Other related problems are urinary tract atony, ataxia, peripheral neuropathy, psychiatric disorders and/or seizures. 2 types of WS may be distinguished: type 1 and type 2 (WS1 and WS2).


overgrowth syndrome

A group of syndromes caused by genetic birth defects that may lead to the development of malignancies. It is characterized by a large body size or large body parts at birth, or excessive body growth early in childhood. Representative examples include neurofibromatosis, Beckwith-Wiedemann syndrome, and Sturge-Weber syndrome.


developmental defect during embryogenesis

A disease that has its basis in the disruption of embryonic morphogenesis.


Rare Neoplastic Syndrome

A broad classification for uncommon disorders in which the development of neoplasms occur in association with a characteristic set of signs or symptoms. These disorders commonly have a genetic basis. The types of neoplasms themselves are not necessarily uncommon.


congenital disorder of glycosylation

Congenital disorder of glycosylation (CDG) is a fast growing group of inborn errors of metabolism characterized by defective activity of enzymes that participate in glycosylation (modification of proteins and other macromolecules by adding and processing of oligosaccharide side chains). CDG is comprised of phenotypically diverse disorders affecting multiple systems including the central nervous system, muscle function, immunity, endocrine system, and coagulation. The numerous entities in this group are subdivided, based on the synthetic pathway affected, into disorder of protein N-glycosylation, disorder of protein O-glycosylation, disorder of multiple glycosylation, and disorder of glycosphingolipid and glycosylphosphatidylinositol anchor glycosylation.


rotenones

Members of the class of rotenoid which consists of a 6a,12a-dihydrochromeno[3,4-b]chromen-12(6H)-one skeleton and its substituted products.


glutathione S-transferase mu 2, initiator methionine removed form (human)

A glutathione S-transferase mu 2 (human) that has had the initiator methionine removed. UniProtKB:P28161, 2-218.


cancer-related nucleoside-triphosphatase isoform 1 (human)

A cancer-related nucleoside-triphosphatase isoform 1 that is encoded in the genome of human.


cytochrome b-245 heavy chain

A protein that is a translation product of the human CYBB gene or a 1:1 ortholog thereof.


cytochrome b-245 heavy chain, initiator methionine removed form (human)

A cytochrome b-245 heavy chain (human) that has had the initiator methionine removed. UniProtKB:P04839, 2-570.


cytochrome b-245 heavy chain isoform 1 (human)

A cytochrome b-245 heavy chain isoform 1 that is encoded in the genome of human.


ATP-dependent RNA helicase DDX19A isoform h2 (human)

An ATP-dependent RNA helicase DDX19A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NUU7-2.


exportin-2 isoform 1 (human)

An exportin-2 isoform 1 that is encoded in the genome of human.


voltage-dependent L-type calcium channel subunit alpha-1C isoform h37 (human)

A voltage-dependent L-type calcium channel subunit alpha-1C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13936-37.


dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B N-glycosylated 6 (human)

A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (human) that has been N-glycosylated at the residue equivalent to Asn-627 of the amino acid sequence represented by UniProtKB:Q8TCJ2-1, in which the glycan composition is represented by GlyTouCan:G01650EU. Example: UniProtKB:Q8TCJ2-1, Asn-627, MOD:00160~GNO:G01650EU.


caveolae-associated protein 2

A protein that is a translation product of the human CAVIN2 gene or a 1:1 ortholog thereof.


[F-actin]-monooxygenase MICAL2 isoform h7 (human)

An [F-actin]-monooxygenase MICAL2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O94851-7.


E3 ubiquitin-protein ligase MARCHF8 isoform h1 (human)

An E3 ubiquitin-protein ligase MARCHF8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5T0T0-1.


eukaryotic translation initiation factor 5A-1 isoform 1 (human)

A eukaryotic translation initiation factor 5A-1 isoform 1 that is encoded in the genome of human.


diacylglycerol O-acyltransferase 2-like protein 6

A protein that is a translation product of the human DGAT2L6 gene or a 1:1 ortholog thereof.


serine/threonine-protein kinase 3

A protein that is a translation product of the human STK3 gene or a 1:1 ortholog thereof.


serine/threonine-protein kinase 3 isoform h1 (human)

A serine/threonine-protein kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13188-1.


serine/threonine-protein kinase 3 phosphorylated 2 (human)

A serine/threonine-protein kinase 3 (human) that has been phosphorylated on the residue at the position equivalent to Thr-180 of the amino acid sequence represented by UniProtKB:Q13188. UniProtKB:Q13188, Thr-180, MOD:00047.


serine/threonine-protein kinase 3 isoform h2 (human)

A serine/threonine-protein kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13188-2.


serine/threonine-protein kinase 3 phosphorylated 1 (human)

A serine/threonine-protein kinase 3 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-81 of the amino acid sequence represented by UniProtKB:Q13188-1. Example: UniProtKB:Q13188-1, Tyr-81, MOD:00048.


long-chain-fatty-acid--CoA ligase ACSBG2 isoform h2 (human)

A long-chain-fatty-acid--CoA ligase ACSBG2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5FVE4-2.


lysozyme-like protein 1 isoform h2 (human)

A lysozyme-like protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6UWQ5-2.


parathyroid hormone-related protein isoform h3 (human)

A parathyroid hormone-related protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12272-3.


catenin beta-1 isoform 1 phosphorylated 4 (human)

A catenin beta-1 isoform 1 phosphorylated 4 in human. UniProtKB:P35222-1, Ser-45, MOD:00046.


L-lactate dehydrogenase C chain, initiator methionine removed form (human)

An L-lactate dehydrogenase C chain (human) that has had the initiator methionine removed. UniProtKB:P07864, 2-332.


mitochondrial peptide methionine sulfoxide reductase isoform h2 (human)

A mitochondrial peptide methionine sulfoxide reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UJ68-2.


clathrin heavy chain 1 isoform 1 (human)

A clathrin heavy chain 1 isoform 1 that is encoded in the genome of human.


aminopeptidase B isoform 1 (human)

An aminopeptidase B isoform 1 that is encoded in the genome of human.


tissue-type plasminogen activator N-glycosylated 68 (human)

A tissue-type plasminogen activator (human) that has been N-glycosylated at the residue equivalent to Asn-219 of the amino acid sequence represented by UniProtKB:P00750-1, in which the glycan structure is represented by GlyTouCan:G91905FJ. Example: UniProtKB:P00750-1, Asn-219, MOD:00160~GNO:G91905FJ.


E3 ubiquitin-protein ligase FANCL isoform 1 (human)

An E3 ubiquitin-protein ligase FANCL isoform 1 that is encoded in the genome of human.


phospholipid-transporting ATPase IK isoform h2 (human)

A phospholipid-transporting ATPase IK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60423-1.


phospholipid-transporting ATPase IK isoform h3 (human)

A phospholipid-transporting ATPase IK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60423-3.


phospholipid-transporting ATPase IK isoform h1 (human)

A phospholipid-transporting ATPase IK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60423-2.


Any member of the class of phenols that is phenol in which the hydrogens at positions 2 and 6 are substituted by a methoxy and an all-trans-polyprenyl group, respectively.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

A protein that is a translation product of the human PDE1A gene or a 1:1 ortholog thereof.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h6 (human)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-6.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h3 (human)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-3.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h2 (human)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-2.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, initiator methionine removed form (human)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that has had the initiator methionine removed. UniProtKB:P54750, 2-535.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h7 (human)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-7.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h5 (human)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-5.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h1 (human)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-1.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h8 (human)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-8.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h9 (human)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-9.


dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h4 (human)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-4.


Grade 3 Colon Adenocarcinoma

A colon adenocarcinoma characterized by the presence of a malignant cellular infiltrate with less than 50% glandular formation.


zinc-alpha-2-glycoprotein N-glycosylated 22 (human)

A zinc-alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-128 of the amino acid sequence represented by UniProtKB:P25311-1, in which the glycan composition is represented by GlyTouCan:G03930BU. Example: UniProtKB:P25311-1, Asn-128, MOD:00160~GNO:G03930BU.


A 1,2-diacyl-sn-glycerol in which both acyl groups are specified as hexanoyl.


cell division cycle 7-related protein kinase isoform h1 (human)

A cell division cycle 7-related protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00311-1.


ketohexokinase isoform A (human)

A ketohexokinase isoform A that is encoded in the genome of human.


ketohexokinase isoform C (human)

A ketohexokinase isoform C that is encoded in the genome of human.


(S)-Bopindolol

A 1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate that has S-configuration.


cytochrome b-c1 complex subunit Rieske, mitochondrial

A protein that is a translation product of the human UQCRFS1 gene or a 1:1 ortholog thereof.


cytochrome b-c1 complex subunit Rieske, mitochondrial, transit peptide removed form (human)

A cytochrome b-c1 complex subunit Rieske, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P47985, 79-274.


cytochrome b-c1 complex subunit Rieske, mitochondrial isoform 1 (human)

A cytochrome b-c1 complex subunit Rieske, mitochondrial isoform 1 that is encoded in the genome of human.


cytochrome b-c1 complex Rieske-derived subunit 9 (human)

A cytochrome b-c1 complex Rieske-derived subunit 9 in human. UniProtKB:P47985, 1-78.


heparin cofactor 2 N-glycosylated 8 (human)

A heparin cofactor 2 (human) that has been N-glycosylated at the residue equivalent to Asn-49 of the amino acid sequence represented by UniProtKB:P05546-1, in which the glycan composition is represented by GlyTouCan:G94917XT. Example: UniProtKB:P05546-1, Asn-49, MOD:00160~GNO:G94917XT.


imidazobenzazepine

Any organic heterotricyclic compound that consists of an imidazole ring ortho-fused to a benzazepine.


Plegomazin

The hydrochloride salt of chlorpromazine.


dibenzooxazepine

An organic heterotricyclic compound consisting of two benzene rings fused to a seven-membered ring containing one oxygen and one nitrogen atom.


organic heterotricyclic compound

An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.


(+)-Ethopropazine

The (R)-enantiomer of profenamine.


phenazines

Any  organonitrogen heterocyclic compound based on a phenazine skeleton and derivatives.


(+)-Tetrabenazine

A 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one in which both stereocentres have R configuration.


Fendosal

A benzoindole that is 4,5-dihydro-3H-benzo[e]indole in which the nitrogen is substituted by a 3-carboxy-4-hydroxyphenyl group. A non-narcotic analgesic and non-steroidal anti-inflammatory drug, it has greater analgesic and inflammatory responses than aspirin but with less gastrointestinal toxicity.


(S)-aceprometazine

The (S)-enantiomer of aceprometazine.


benzochromenone

A benzochromene in which the heterotricyclic ring system is substituted by an oxo group.


Phenothiazine

The 10H-tautomer of phenothiazine.


Clopenthixol

A thioxanthene derivative having a chloro substituent at the 2-position and an alkylidene group at the 10-position with undefined double bond stereochemistry.


imidazobenzodiazepine

Any organic heterotricyclic compound that is any benzodiazepine which is ortho-fused with a imidazole.


psoralens

A furanocoumarin with a 7H-furo[3,2-g]chromen-7-one skeleton and its substituted derivatives thereof.


furanocoumarin

Any furochromene that consists of a furan ring fused with a coumarin. The fusion may occur in different ways in give several isomers.


(S)-etodolac

The S-enantiomer of etodolac. It is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory, whereas the enantiomer, (R)-etodolac, is inactive. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain.


nocamycin E

An organic heterotricyclic compound and tetramic acid derivative isolated from a mutant strain of Saccharothrix syringae. Nocamycin E exhibits considerably lower antibacterial activity than the corresponding methyl ester, nocamycin I.


(R)-Carprofen

The (R)-(-)-enantomer of carprofen.


The (S)-(+)-enantiomer of carprofen.


pyranobenzodioxin

Any organic heterotricyclic compound whose core skeleton consists of a benzodioxin ring that is ortho-fused to a pyran ring.


Nocamycin I

An organic heterotricyclic compound and tetramic acid derivative originally isolated from an unidentified oligosporic actinomycete strain (no. E864-861) and found to be active against both Gram-positive and Gram-negative anaerobic bacteria as well as some aerobic bacteria such as Streptococci. The methyl ester of nocamycin E.


Aceprometazine, (R)-

The (R)-enantiomer of aceprometazine.


A dibenzooxepine resulting from the demethylation of the antidepressant doxepin. It is the active metabolite of doxepin.


Flupentixol

A flupenthixol in which the double bond adopts a cis-configuration.


pyridochromene

An organic heterotricyclic compound composed of a pyridine ring fused to a chromene.


(R)-Etodolac

The R-enantiomer of etodolac. It is inactive, in contrast to the enantiomer, (S)-etodolac, which is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain.


A furanocoumarin which bears a hydroxy group at position 8.


A 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one in which both stereocentres have S configuration.


Chlorprothixine

A chlorprothixene in which the double bond adopts an (E)-configuration.


Basic Orange 14

Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.


Chlorprothixene

A chlorprothixene in which the double bond adopts a (Z)-configuration.


benzoquinolizine

Any organic heterotricyclic compound with a skeleton consisting of a quinolizine fused to a benzene ring.


dipyridodiazepine

An organic heterotricyclic compound whose skeleton consists of a diazepine ring which is fused to two pyridine rings.


A furanocoumarin which bears a hydroxy group at position 5.


flavin

A derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position.


pyridobenzodiazepine

Any three-ring heterocyclic compound with a skeleton consisting of a pyridine ring ortho-fused to a benzodiazepine.


(S)-ethopropazine

The (S)-enantiomer of profenamine.


triazolobenzodiazepine

Any organic heterotricyclic compound that is any benzodiazepine which is ortho-fused with a triazole.


An imidazoquinoline that is 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one which is substituted at positions 1, 3, and 8 by by p-(pyrrol-1-yl)phenyl, methyl, and pyridin-3-yl group, respectively. A potent and specific inhibitor of Target Of Rapamycin Complex 2 (TORC2).


thioxanthenes

Thioxanthene and its substitution derivatives.


Nodakenetin

A marmesin with R-configuration.


oxazinoquinoline

Any organic heterotricyclic compound based on a skeleton comprised of an oxazine ring fused onto a quinoline system.


receptor-type tyrosine-protein phosphatase C isoform CD45RA (human)

A receptor-type tyrosine-protein phosphatase C isoform CD45RA that is encoded in the genome of human.


ceramide synthase 6 isoform 1 (human)

A ceramide synthase 6 isoform 1 that is encoded in the genome of human.


fibronectin O-glycosylated 10 (human)

A fibronectin (human) that has been O-glycosylated at the residue equivalent to Thr-278 of the amino acid sequence represented by UniProtKB:P02751-15, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P02751-15, Thr-278, MOD:00005~GNO:G58001LT.


synaptotagmin-7 isoform r7 (rat)

A synaptotagmin-7 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q62747-7.


transient receptor potential cation channel subfamily M member 2 isoform h2 (human)

A transient receptor potential cation channel subfamily M member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O94759-2.


phosphatidylserine lipase ABHD16A isoform 1 (human)

A phosphatidylserine lipase ABHD16A isoform 1 that is encoded in the genome of human.


inborn organic aciduria

An inherited disorder that affects the metabolism of any acidic compound containing carbon in a covalent linkage.


HSD10 disease, neonatal type

HSD10 disease, neonatal type is the most severe form of HSD10 disease, a rare neurometabolic disorder. It is characterized by onset of severe metabolic/lactic acidosis, neurological and psychomotor delay, seizures and severe progressive hypertrophic cardiomyopathy in the neonatal period. Hepatic involvement and coagulopathy are rare. The disease is fatal within the first months of life.


maple syrup urine disease type 1A

A maple syrup urine disease caused by mutations in BCKDHA.


thiamine-responsive maple syrup urine disease

Thiamine-responsive maple syrup urine disease (thiamine-responsive MSUD) is a less severe variant of MSUD that manifests with a phenotype similar to intermediate MSUD but that responds positively to treatment with thiamine.


inherited fatty acid metabolism disorder

A group of genetic disorders that result from the inability to produce or use an enzyme required to oxidize fatty acids, resulting in an inability to generate energy from fatty acid sources.


multiple carboxylase deficiency

Multiple carboxylase deficiency (MCD) is a term used to describe inborn errors of biotin metabolism characterized by reduced activities of biotin-dependent enzymes resulting in a wide spectrum of symptoms, including feeding difficulty, breathing difficulties, lethargy, seizures, skin rash, alopecia, and developmental delay.


methylmalonic aciduria and homocystinuria

An inborn error of vitamin B12 (cobalamin) metabolism characterized by megaloblastic anemia, lethargy, failure to thrive, developmental delay, intellectual deficit and seizures. There are four complementation classes of cobalamin defects (cblC, cblD, cblF and cblJ) that are responsible for methylmalonic acidemia - homocystinuria (methylmalonic acidemia - homocystinuria cblC, cblD cblF and cblJ).


disorder of fatty acid oxidation and ketogenesis


inherited lipoic acid biosynthesis defect

An inherited metabolic disease that is has its basis in the disruption of lipoate biosynthetic process.


vitamin B12-unresponsive methylmalonic acidemia type mut0

Vitamin B12-unresponsive methylmalonic acidemia type mut0 is an inborn error of metabolism characterized by recurrent ketoacidotic comas or transient vomiting, dehydration, hypotonia and intellectual deficit, which does not respond to administration of vitamin B12.


2-hydroxyglutaric aciduria

2-Hydroxyglutaric aciduria is a group of neurometabolic disorders with a wide clinical spectrum ranging from severe neonatal presentations to progressive forms, and asymptomatic cases, characterized biochemically by increased levels of 2-hydroxyglutaric acid in the plasma, cerebrospinal fluid and urine.


cerebral organic aciduria

A inherited organic acidemia that involves the brain.


mitochondrial short-chain Enoyl-Coa hydratase 1 deficiency

An autosomal recessive condition caused by mutation(s) in the ECHS1 gene, encoding enoyl-CoA hydratase, mitochondrial. The condition represents a clinical spectrum in which there are multiple phenotypes.


HSD10 disease, infantile type

HSD10 disease, infantile type is a clinical subtype of HSD10 disease, a rare neurometabolic disorder. It is characterized by normal early development until 6-18 months of life, followed by progressive neurodegeneration manifesting with developmental regression, progressive visual and hearing troubles, seizures, epilepsy, severe cardiomyopathy, lethargy, hypotonia, poor feeding, choreoathetosis, and movement disorders. Elevated blood levels of isoleucine metabolites and their excretion in urine are reported. The disease is usually fatal around 2-4 years of age.


3-methylcrotonyl-CoA carboxylase deficiency (3-MCCD) is an inherited disorder of leucine metabolism characterized by a highly variable clinical picture ranging from metabolic crisis in infancy to asymptomatic adults.


severe Canavan disease

Severe Canavan disease (CD) is a rapidly progressing neurodegenerative disorder characterized by leukodystrophy with macrocephaly, severe developmental delay and hypotonia.


mild Canavan disease

Mild Canavan disease (CD) is a neurodegenerative disorder characterized by mild speech delay or motor development.


maple syrup urine disease type 1B

A maple syrup urine disease caused by mutations in BCKDHB.


intermediate maple syrup urine disease

Intermediate maple syrup urine disease (intermediate MSUD) is a milder form of MSUD characterized by persistently raised branched-chain amino acids (BCAAs) and ketoacids, but fewer or no acute episodes of decompensation.


intermittent maple syrup urine disease

Intermittent maple syrup urine disease (intermittent MSUD) is a mild form of MSUD where patients (when well) are asymptomatic with normal levels of branched-chain amino acids (BCAAs) but with catabolic stress are at risk of acute decompensation with ketoacidosis, which can lead to cerebral edema and coma if untreated.


inborn aminoacylase deficiency

An inherited metabolic disease that is has its basis in the disruption of aminoacylase activity.


classic maple syrup urine disease

Classic maple syrup urine disease (classic MSUD) is the most severe and probably common form of MSUD characterized by a maple syrup odor in the cerumen at birth, poor feeding, lethargy and focal dystonia, followed by progressive encephalopathy and central respiratory failure if untreated.


maple syrup urine disease type 2

A maple syrup urine disease caused by mutations in DBT.


vitamin B12-unresponsive methylmalonic acidemia type mut-

Vitamin B12-unresponsive methylmalonic acidemia type mut- is an inborn error of metabolism characterized by recurrent ketoacidotic comas or transient vomiting, dehydration, hypotonia and intellectual deficit, which does not respond to administration of vitamin B12.


vitamin B12-responsive methylmalonic acidemia

Vitamin B12-responsive methylmalonic acidemia (MA) is an inborn error of vitamin B12 (cobalamin) metabolism characterized by recurrent ketoacidotic comas or transient vomiting, dehydration, hypotonia and intellectual deficit, which responds to vitamin B12. There are three types: cblA, cblB and cblD-variant 2 (cblDv2).


An iminium salt composed of 4-{(4-anilinonaphthalen-1-yl)[4-(diethylamino)phenyl]methylidene}-N,N-diethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio.


hydroxymethylglutaryl-CoA synthase, mitochondrial, transit peptide removed form (human)

A hydroxymethylglutaryl-CoA synthase, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P54868, 38-508.


frizzled-4 isoform 1 (human)

A frizzled-4 isoform 1 that is encoded in the genome of human.


synaptotagmin-like protein 2 isoform h3 (human)

A synaptotagmin-like protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCH5-4.


solute carrier family 22 member 6 isoform h1 (human)

A solute carrier family 22 member 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q4U2R8-1.


acyl-coenzyme A synthetase ACSM1, mitochondrial isoform h2 (human)

An acyl-coenzyme A synthetase ACSM1, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08AH1-2.


galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform 1 (human)

A galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform 1 that is encoded in the genome of human.


gamma-aminooctyl-GTP

A nucleoside triphosphate analogue that is GTP in which one of the OH groups at the gamma-position of the triphosphate is replaced by an 8-aminooctylamino group.


G protein-activated inward rectifier potassium channel

An inwardly rectifying potassium channel protein that has core architecture consisting of an Inward rectifier potassium channel domain (Pfam:PF01007), which may be preceeded by an Inward rectifier potassium channel N-terminal domain (Pfam:PF08466).


inward rectifier potassium channel 13 isoform 1 (human)

An inward rectifier potassium channel 13 isoform 1 that is encoded in the genome of human.


ATP-sensitive inward rectifier potassium channel 11

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ11 gene or a 1:1 ortholog thereof.


ATP-sensitive inward rectifier potassium channel 11 isoform h2 (human)

An ATP-sensitive inward rectifier potassium channel 11 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14654-2.


G protein-activated inward rectifier potassium channel 1 isoform 1 (human)

A G protein-activated inward rectifier potassium channel 1 isoform 1 that is encoded in the genome of human.


inward rectifier potassium channel 16

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ16 gene or a 1:1 ortholog thereof.


ATP-sensitive inward rectifier potassium channel 1

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ1 gene or a 1:1 ortholog thereof.


G protein-activated inward rectifier potassium channel 3 isoform 1 (human)

A G protein-activated inward rectifier potassium channel 3 isoform 1 that is encoded in the genome of human.


inward rectifier potassium channel 13

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ13 gene or a 1:1 ortholog thereof.


ATP-sensitive inward rectifier potassium channel 8

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ8 gene or a 1:1 ortholog thereof.


G protein-activated inward rectifier potassium channel 1

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ3 gene or a 1:1 ortholog thereof.


ATP-sensitive inward rectifier potassium channel 1 isoform h2 (human)

An ATP-sensitive inward rectifier potassium channel 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48048-2.


ATP-sensitive inward rectifier potassium channel 10 isoform 1 (human)

An ATP-sensitive inward rectifier potassium channel 10 isoform 1 that is encoded in the genome of human.


inward rectifier potassium channel 4

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ4 gene or a 1:1 ortholog thereof.


inward rectifier potassium channel 2

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ2 gene or a 1:1 ortholog thereof.


ATP-sensitive inward rectifier potassium channel 11 isoform 1 (human)

An ATP-sensitive inward rectifier potassium channel 11 isoform 1 that is encoded in the genome of human.


ATP-sensitive inward rectifier potassium channel 8 isoform 1 (human)

An ATP-sensitive inward rectifier potassium channel 8 isoform 1 that is encoded in the genome of human.


ATP-sensitive inward rectifier potassium channel 1 isoform 1 (human)

An ATP-sensitive inward rectifier potassium channel 1 isoform 1 that is encoded in the genome of human.


ATP-sensitive inward rectifier potassium channel 1 isoform h3 (human)

An ATP-sensitive inward rectifier potassium channel 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48048-3.


G protein-activated inward rectifier potassium channel 4

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ5 gene or a 1:1 ortholog thereof.


inward rectifier potassium channel 2 isoform 1 (human)

An inward rectifier potassium channel 2 isoform 1 that is encoded in the genome of human.


G protein-activated inward rectifier potassium channel 1 isoform h2 (human)

A G protein-activated inward rectifier potassium channel 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48549-2.


G protein-activated inward rectifier potassium channel 4 isoform 1 (human)

A G protein-activated inward rectifier potassium channel 4 isoform 1 that is encoded in the genome of human.


ATP-sensitive inward rectifier potassium channel 15

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ15 gene or a 1:1 ortholog thereof.


ATP-sensitive inward rectifier potassium channel 10

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ10 gene or a 1:1 ortholog thereof.


ATP-sensitive inward rectifier potassium channel 15 isoform 1 (human)

An ATP-sensitive inward rectifier potassium channel 15 isoform 1 that is encoded in the genome of human.


G protein-activated inward rectifier potassium channel 3

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ9 gene or a 1:1 ortholog thereof.


inward rectifier potassium channel 4 phosphorylated 1 (human)

An inward rectifier potassium channel 4 (human) that has been phosphorylated at Tyr-234. UniProtKB:P48050, Tyr-234, MOD:00048.


G protein-activated inward rectifier potassium channel 2

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ6 gene or a 1:1 ortholog thereof.


ATP-sensitive inward rectifier potassium channel 12

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ12 gene or a 1:1 ortholog thereof.


ATP-sensitive inward rectifier potassium channel 14

A G protein-activated inward rectifier potassium channel that is a translation product of the human KCNJ14 gene or a 1:1 ortholog thereof.


inward rectifier potassium channel 13 isoform h2 (human)

An inward rectifier potassium channel 13 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60928-2.


Hydroxythiamine

A organic chloride salt having oxythiamine as the counterion.


Ral guanine nucleotide dissociation stimulator isoform h2 (human)

A Ral guanine nucleotide dissociation stimulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12967-2.


Ral guanine nucleotide dissociation stimulator

A protein that is a translation product of the human RALGDS gene or a 1:1 ortholog thereof.


Ral guanine nucleotide dissociation stimulator isoform h4 (human)

A Ral guanine nucleotide dissociation stimulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12967-4.


Ral guanine nucleotide dissociation stimulator isoform h6 (human)

A Ral guanine nucleotide dissociation stimulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12967-6.


Ral guanine nucleotide dissociation stimulator isoform h3 (human)

A Ral guanine nucleotide dissociation stimulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12967-3.


Ral guanine nucleotide dissociation stimulator isoform h5 (human)

A Ral guanine nucleotide dissociation stimulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12967-5.


Ral guanine nucleotide dissociation stimulator isoform h1 (human)

A Ral guanine nucleotide dissociation stimulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12967-1.


solute carrier organic anion transporter family member 2A1

A solute carrier organic anion transporter family member that is a translation product of the human SLCO2A1 gene or a 1:1 ortholog thereof.


immunoglobulin heavy constant mu N-glycosylated 41 (human)

An immunoglobulin heavy constant mu (human) that has been N-glycosylated at the residue equivalent to Asn-272 of the amino acid sequence represented by UniProtKB:P01871-1, in which the glycan structure is represented by GlyTouCan:G65219TP. Example: UniProtKB:P01871-1, Asn-272, MOD:00160~GNO:G65219TP.


cartilage oligomeric matrix protein N-glycosylated 2 (human)

A cartilage oligomeric matrix protein (human) that has been N-glycosylated at the residue equivalent to Asn-742 of the amino acid sequence represented by UniProtKB:P49747-1, in which the glycan composition is represented by GlyTouCan:G80920RR. Example: UniProtKB:P49747-1, Asn-742, MOD:00160~GNO:G80920RR.


inherited cutis laxa

An instance of cutis laxa that is inherited.


pancreatic alpha-amylase isoform h1 (human)

A pancreatic alpha-amylase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04746-1.


protein-glutamine gamma-glutamyltransferase E isoform 1 (human)

A protein-glutamine gamma-glutamyltransferase E isoform 1 that is encoded in the genome of human.


5'(3')-deoxyribonucleotidase, cytosolic type isoform h2 (human)

A 5'(3')-deoxyribonucleotidase, cytosolic type (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TCD5-2.


fermitin family homolog 2 isoform h2 (human)

A fermitin family homolog 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96AC1-2.


calpain-10 isoform F (human)

A calpain-10 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HC96-6.


mothers against decapentaplegic homolog 7 isoform h2 (human)

A mothers against decapentaplegic homolog 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15105-2.


3-Amino-5-methyl-4-[[3-(4-morpholinyl)propylamino]-oxomethyl]-2-thiophenecarboxylic acid ethyl ester


equilibrative nucleoside transporter 1 isoform h2 (human)

An equilibrative nucleoside transporter 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99808-2.


DNA-directed RNA polymerase III subunit RPC2

A protein that is a translation product of the human POLR3B gene or a 1:1 ortholog thereof.


DNA-directed RNA polymerase III subunit RPC2 isoform h2 (human)

A DNA-directed RNA polymerase III subunit RPC2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NW08-2.


DNA-directed RNA polymerase III subunit RPC2 isoform 1 (human)

A DNA-directed RNA polymerase III subunit RPC2 isoform 1 that is encoded in the genome of human.


methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA R385S (human)

A methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant (human) that has a Ser residue at the position equivalent to Arg-385 of the amino acid sequence represented by UniProtKB:Q96RQ3. UniProtKB:Q96RQ3, Arg-385, CHEBI:29999.


methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant (human)

A methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (human) that has at least one amino acid residue that differs from the corresponding residue found in another methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (human) when such a difference arises as the result of genetic differences, i.e., different alleles of methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (human). Operationally, this means the sequence representation of the methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (human) has at least one amino acid residue that differs from the equivalent residue found in the sequence represented by UniProtKB:Q96RQ3-1.


methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA A289V (human)

A methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant (human) that has a Val residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:Q96RQ3. UniProtKB:Q96RQ3, Ala-289, CHEBI:30015.


methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA L437P (human)

A methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant (human) that has a Pro residue at the position equivalent to Leu-437 of the amino acid sequence represented by UniProtKB:Q96RQ3. UniProtKB:Q96RQ3, Leu-437, CHEBI:50342.


methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant MCCA D532H (human)

A methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial sequence variant (human) that lacks the region encoded by exon 13 and shifts the reading frame due to the missense mutation D532H altering the splice site at the position equivalent to Asp-532 of the amino acid sequence represented by UniProtKB:Q96RQ3.


ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform h1 (human)

An ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13822-1.


ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform h3 (human)

An ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13822-3.


cadherin-12 isoform 1 (human)

A cadherin-12 isoform 1 that is encoded in the genome of human.


serine/threonine-protein kinase ULK3 isoform 1 (human)

A serine/threonine-protein kinase ULK3 isoform 1 that is encoded in the genome of human.


vitamin B2

Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).


Vilazodone hydrochloride

A hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder.


A 3-oxo Delta(4)-steroid that is testosterone carrying an additional oxo substituent at position 11.


interferon alpha-14

An interferon alpha that is a translation product of the human IFNA14 gene or a 1:1 ortholog thereof.


interferon alpha-14 N-glycosylated 2 (human)

An interferon alpha-14 (human) that has been N-glycosylated at the residue equivalent to Asn-95 of the amino acid sequence represented by UniProtKB:P01570-1, in which the glycan structure is represented by GlyTouCan:G75903TQ. Example: UniProtKB:P01570-1, Asn-95, MOD:00160~GNO:G75903TQ.


interferon alpha-14 N-glycosylated 1 (human)

An interferon alpha-14 (human) that has been N-glycosylated at the residue equivalent to Asn-95 of the amino acid sequence represented by UniProtKB:P01570-1, in which the glycan structure is represented by GlyTouCan:G07392QY. Example: UniProtKB:P01570-1, Asn-95, MOD:00160~GNO:G07392QY.


interferon alpha-14, signal peptide removed form (human)

An interferon alpha-14 (human) that has had the signal peptide removed. UniProtKB:P01570, 24-189.


CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human)

A CD14 molecule isoform 1 cleaved 2 GPI-anchored form in human. UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167.


3-hydroxyacyl-CoA dehydrogenase type-2 isoform h2 (human)

A 3-hydroxyacyl-CoA dehydrogenase type-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99714-2.


3-hydroxyacyl-CoA dehydrogenase type-2 isoform h1 (human)

A 3-hydroxyacyl-CoA dehydrogenase type-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99714-1.


3-hydroxyacyl-CoA dehydrogenase type-2, initiator methionine removed form (human)

A 3-hydroxyacyl-CoA dehydrogenase type-2 (human) that has had the initiator methionine removed. UniProtKB:Q99714, 2-261.


cAMP-responsive element modulator isoform h11 (human)

A cAMP-responsive element modulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03060-13.


NAD kinase isoform h1 (human)

An NAD kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95544-1.


NAD kinase isoform h2 (human)

An NAD kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95544-2.


DNA replication licensing factor MCM4, initiator methionine removed form (human)

A DNA replication licensing factor MCM4 (human) that has had the initiator methionine removed. UniProtKB:P33991, 2-863.


acyl-coenzyme A thioesterase 2, mitochondrial isoform h2 (human)

An acyl-coenzyme A thioesterase 2, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49753-2.


acyl-coenzyme A thioesterase 2, mitochondrial isoform h1 (human)

An acyl-coenzyme A thioesterase 2, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49753-1.


nuclear factor of activated T-cells, cytoplasmic 4 isoform h19 (human)

A nuclear factor of activated T-cells, cytoplasmic 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14934-19.


voltage-gated potassium channel subunit beta-2 phosphorylated 1 (human)

A voltage-gated potassium channel subunit beta-2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-266 of the amino acid sequence represented by UniProtKB:Q13303-1. Example: UniProtKB:Q13303-1, Ser-266, MOD:00046.


sperm-egg fusion protein Juno isoform h2 (human)

A sperm-egg fusion protein Juno (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A6ND01-2.


sperm-egg fusion protein Juno isoform h1 (human)

A sperm-egg fusion protein Juno (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A6ND01-1.


isoprenoid

Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives.


A 3beta-hydroxy-4alpha-formyl-4beta-methylsteroid that is 24-methylene-9beta-9,19-cyclolanostane-3beta,28-diol in which the hydroxy group at position 28 has been oxidised to give the corresponding aldehyde.


Gypenoside IV

A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-xylopyranosyl-(1->6)-beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.


ginsenoside C-K

A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.


A cholestanoid that is 5alpha-cholesta-8,14-dien-3beta-ol bearing two additional methyl substituents at position 4.


Nerylneryl pyrophosphate

A polyprenol diphosphate having geranylgeranyl as the polyprenyl component.


carotene

Hydrocarbon carotenoids.


tetraterpenoid

Any terpenoid derived from a tetraterpene. The term includes compounds in which the C40 skeleton of the parent tetraterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).


beta-CITRONELLOL, (+/-)-

A monoterpenoid that is oct-6-ene substituted by a hydroxy group at position 1 and methyl groups at positions 3 and 7.


Limonene, (+/-)-

A monoterpene that is cyclohex-1-ene substituted by a methyl group at position 1 and a prop-1-en-2-yl group at position 4 respectively.


Protopanaxadiol

A diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-R position.


Retinyl octanoate

An all-trans-retinyl ester obtained by formal condensation of the carboxy group of octanoic acid with the hydroxy group of all-trans-retinol.


A tetracyclic triterpenoid that is dammarenediol-II where the hydrogen of the hydroxy group at position 20 is replaced by a beta-D-glucoside.


A pentacyclic triterpenod that is 9beta,19-cyclolanost-24-ene which is substituted by hydroxy groups at the 3beta and 28 positions.


squalene triterpenoid

A triterpenoid based on a  squalene skeleton and its substituted derivatives thereof.


Ginsenoside Rf

A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.


Geranyl phosphate

A prenol phosphate resulting from the formal condensation of the terminal allylic hydroxy group of a polyprenol with 1 mol eq. of phosphoric acid.


A car-3-ene (3,7,7-trimethylbicyclo[4.1.0]hept-3-ene) that has R configuration at position 1 and S configuration at position 6.


Sesquiterpenes

A C15 terpene.


polyprenol

Any member of the class of  prenols possessing the general formula H-[CH2C(Me)=CHCH2]nOH in which the carbon skeleton is composed of more than one isoprene units.


triterpenoid

Any terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).


A steroid acid that is 4beta,14-dimethyl-5alpha,9beta-9,19-cyclocholest-24-en-3beta-ol in which the 4alpha hydrogen has been replaced by a carboxy group.


Pneumocysterol

A tetracyclic triterpenoid that is (24Z)-24-ethylidenelanost-8-ene substituted by a hydroxy group at the 3beta position.


tetracyclic diterpenoid

A diterpenoid with a tetracyclic skeleton.


polyterpene

A C5n terpene, where n is greater than 8.


Ginsenoside Rh2

A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.


A cholestanoid that is 5alpha-cholesta-8-en-3beta-ol bearing two additional methyl substituents at position 4.


3,4-Didehydroretinoic acid

A retinoid obtained by 3,4-desaturation of beta-ionone ring of all-trans-retinoic acid


A car-3-ene (3,7,7-trimethylbicyclo[4.1.0]hept-3-ene) that has S configuration at position 1 and R configuration at position 6.


Major species at pH 7.3


Ginsenoside RG2

A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.


terpene

A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH2=C(CH3)CH=CH2].


Ginsenoside Rh1

A tetracyclic triterpenoid that is (20S)-protopanaxadiol which is substituted by beta-D-glucoside at the 6alpha position.


sesquiterpenoid

Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).


Ginsenoside Rc

A ginsenoside found in Panax ginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside and alpha-L-arabinofuranosyl-(1->6)-beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.


A perillyl alcohol in which the chiral centre has R configuration.


Perilla alcohol

A perillyl alcohol in which the chiral centre has S configuration.


(+)-Menthol

A p-menthan-3-ol which has (1S,2R,5S)-stereochemistry. In contrast to (-)-menthol, the (+)-enantiomer occurs only rarely in nature.


p-menthadiene

A monoterpene that consists of an unsaturated p-menthane skeleton having two double bonds.


A 3beta-hydroxy-4alpha-formyl-4beta-methylsteroid that is 9beta-9,19-cyclolanost-24-ene-3beta,28-diol in which the hydroxy group at position 28 has been oxidised to the corresponding aldehyde.


tetracyclic triterpenoid

Any triterpenoid consisting of a tetracyclic skeleton.


(+)-alpha-Phellandrene

The (5S)-stereoisomer of alpha-phellandrene (5-isopropyl-2-methylcyclohexa-1,3-diene).


A squalene triterpenoid obtained by formal epoxidation across the 2,3 C=C bond of squalene.


all-trans-polyprenyl diphosphate

A polyprenol diphosphate of unspecified chain-length with all double bonds having (E)-configuration.


Retinyl dodecanoate

An all-trans-retinyl ester obtained by formal condensation of the carboxy group of dodecanoic (lauric) acid with the hydroxy group of all-trans-retinol.


ginsenoside Mc

A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions and in which the hydroxy group at position 20 has been converted to the corresponding alpha-L-arabinofuranosyl-beta-D-glucopyranoside.


A tetracyclic triterpenoid that is lanost-8-ene carrying hydroxy and oxo substituents at positions 3beta and 30 respectively.


A retinoid that consists of 3,7-dimethylnona-2,4,6,8-tetraenoic acid having a 4-methoxy-2,3,6-trimethylphenyl group attached at position 9.


Diosgenin

A  sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.


Eburicol

A tetracyclic triterpenoid that is 24,25-dihydrolanosterol carrying an additional methylene substituent at position 24. A natural product found in Taiwanofungus camphoratus.


A tetracyclic triterpenoid sapogenin (isolated from ginseng and notoginseng) that is that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions and in which a double bond has been introduced at the 24-25 position.


A 3beta-hydroxy-4alpha-formyl-4beta-methylsteroid that is 24-methylenecycloartanol in which the alpha-methyl substituent at position 4 has been substituted by a hydroxy group.


Ginsenoside C

A ginsenoside found in Panax ginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside and alpha-L-arabinopyranosyl-(1->6)-beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.


A tetracyclic triterpenoid that is lanost-8-ene carrying two hydroxy substituents at positions 3beta and 30.


A diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-S position.


monoterpenoid

Any terpenoid derived from a monoterpene. The term includes compounds in which the C10 skeleton of the parent monoterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).


phorbol ester

Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.


Hainanic acid A

A tetracyclic triterpenoid isolated from the fruiting bodies of Ganoderma hainanense.


prenols

Any alcohol possessing the general formula H-[CH2C(Me)=CHCH2]nOH in which the carbon skeleton is composed of one or more isoprene units (biogenetic precursors of the isoprenoids).


xanthophyll

A subclass of carotenoids consisting of the oxygenated carotenes.


monoterpene

A C10 terpene.


ginsenoside C-Y

A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding alpha-L-arabinopyranosyl-(1->6)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.


A pentacyclic triterpenoid that is (9beta)-24-methylene-9,19-cyclolanostane which carries a hydroxy group at position 3beta. It is isolated from several plant species including Euphorbia, Epidendrum, Psychotria and Sideritis.


Vitamin A2

A retinoid derived from 3,4-desaturation of the beta-ionone ring of all-trans-retinol.


all-trans-alpha-Carotene

A cyclic carotene with a beta- and an epsilon-ring at opposite ends respectively.


A 3beta-hydroxy steroid that is (3beta,5alpha)-4,4,14-trimethylandrost-8-en-3-ol which is substituted by a (3E,6S)-2-methoxy-2-methylhept-3-en-6-yl group at position 17.


ganoderol B

A tetracyclic triterpenoid that is lanosta-7,9(11),24-triene which is substituted by hydroxy groups at positions 3 and 27. It has been isolated from several Ganoderma species.


Gypenoside LXXV

A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta,  12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.


A decaprenyl diphosphate having (Z)-stereochemistry in all but one of the double bonds.


ginsenoside F2

A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 position.


A 3beta-hydroxy steroid having an ent-dammarane skeleton with a double bond at C-24 and a Z-double bond at C-17(20).


(S)-4-hydroxyretinoic acid

An all-trans-4-hydroxyretinoic acid in which the 4-hydroxy group has S-configuration.


CID 9890474

A tetracyclic triterpenoid sapogenin (isolated from ginseng) that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 positions and in which a double bond has been introduced at the 24-25 position.


A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).


retinoid

Oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof.


tetraterpene

A C40 terpene.


vitamin A myristate

An all-trans-retinyl ester obtained by formal condensation of the carboxy group of tetradecanoic acid with the hydroxy group of all-trans-retinol.


Mogrol

A tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii.


carotenoid beta-end derivative

Any carotenoid derivative with an beta-end group


Caryophyllene,alpha + beta mixt.

A sesquiterpene with a [7.2.0]-bicyclic structure comprising fused 9- and 4-membered rings, with a trans-ring junction, a trans-double bond between the 4- and 5-positions of the 9-membered ring, a methylidene group at position 9, and methyl groups at positions 3, 11, and 11. The most commonly occurring form is the (1R,9S)-(-)-enantiomer, which is found in many essential oils, particularly clove oil.


terpenoid

Any isoprenoid that is a natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the parent terpene. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group.


Ginsenoside Rg1

A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 position.


A 3beta-sterol that is lanosterol carrying an oxo group at position 26.


ginsenoside Mx

A ginsenoside found in Panax ginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions and in which the hydroxy group at position 20 has been converted to the corresponding beta-D-xylopyranosyl-beta-D-glucopyranoside.


carotenoid

One of a class of tetraterpenoids (C40), formally derived from the acyclic parent, psi,psi-carotene by hydrogenation, dehydrogenation, cyclization, oxidation, or combination of these processes. This class includes carotenes, xanthophylls and certain compounds that arise from rearrangement of the skeleton of psi,psi-carotene or by loss of part of this structure. Retinoids are excluded.


Notoginsenoside R1

A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.


Parkeol

A tetracyclic triterpenoid comprised of a lanostane skeleton which is 3beta-hydroxylated and has double bonds at the 9(11)- and 24-positions.


All-trans-decaprenyl diphosphate

A decaprenyl diphosphate having (E)-stereochemistry exclusively in the double bonds.


Ginsenoside B2

A ginsenoside found in Panax ginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.


alpha-PINENE

A pinene that is bicyclo[3.1.1]hept-2-ene substituted by methyl groups at positions 2, 6 and 6 respectively.


Ginsenoside F1

A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.


triterpene

A C30 terpene.


terpene glycoside

A terpenoid in which one or more hydroxy functions are glycosylated.


retinyl ester

A carboxylic ester obtained by formal condensation of the hydroxy group of retinol with the carboxy group of any carboxylic acid.


3,7,11,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaenyl phosphono hydrogen phosphate

A polyprenol diphosphate compound having six prenyl units with undefined stereochemistry about the double bonds.


Gypenoside XVII

A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranoside and beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.


apo carotenoid

A compound arising from loss of part of the carotene skeleton (excluding retinoids)


A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).


Decaprenyl diphosphate

A decaprenyl diphosphate having (Z)-stereochemistry about all but one of the double bonds.


Cyclolaudenol

A pentacyclic triterpenoid that is (24S)-methyl-9beta,19-cyclolanost-25-ene which carries a hydroxy group at position 3beta. It is isolated from several plant species inclduing Turraeanthus  and Tillandsia.


Retinyl heptanoate

An all-trans-retinyl ester obtained by formal condensation of the carboxy group of heptanoic acid with the hydroxy group of all-trans-retinol.


Carveol

A limonene monoterpenoid that is cyclohex-2-en-1-ol substituted by a methyl group at position 2 and a prop-1-en-2-yl group at position 5.


all-trans-retinyl ester

A retintinyl ester in which all double bonds of the retinyl side-chain have trans-configuration.


diterpenoid

Any terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).


A polyprenol diphosphate compound having eleven prenyl units with undefined stereochemistry about the double bonds.


A 3beta-sterol that is lanosterol carrying a hydroxy group at position 26.


triterpenoid saponin

A terpene glycoside in which the terpene moiety is a triterpenoid.


alpha-PHELLANDRENE, (-)-

The (R)-(-)-stereoisomer of alpha-phellandrene.


phenylalanine--tRNA ligase alpha subunit isoform h2 (human)

A phenylalanine--tRNA ligase alpha subunit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y285-2.


tRNA modification GTPase GTPBP3, mitochondrial isoform h3 (human)

A tRNA modification GTPase GTPBP3, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969Y2-3.


A heme that consists of sirohaem lacking the two carboxy groups at positions 12 and 18.


ferroheme

Any iron(II)--porphyrin coordination complex.


A carboxylic ester that is the methyl ester of cis-heme d hydroxychlorin gamma-spirolactone.


A ferroheme having a methyl group at ring position 8 and an isoprenoid chain at position 2.


protoheme IX

A metalloprotoporphyrin in which the four pyrrole nitrogens of the protoporphyrin moiety are coordinated to iron. It is the most abundant of the heme compounds.


Ferroprotoporphyrin IX

Heme b in which the iron has oxidation state +2.


Ferriheme

Heme b in which the iron has oxidation state +3.


A metallochlorin that is ferroheme b which is trans-dihydroxylated at positions 5 and 6.


cis-Heme D hydroxychlorin gamma-spirolactone

A metallochlorin that is heme d in which the hydroxy group and the carboxy group of the 6-carboxyethyl substituent have undergone intramolecular condensation to afford the corresponding gamma-spirolactone.


ferriheme a(1-)

Ferriheme a protonated to pH 7.3.


ferroheme c

A ferroheme coordination complex bearing 1-sulfanylethyl substituents at the 8- and 13-positions.


A metallochlorin that is the iron(II) complex of 7,8-dihydroporphyrin which is substituted by methyl groups at positions 3, 7, 7, 8, 12, 13, and 17, and by carboxyethyl groups at positions 2 and 18.


A metallochlorin that is ferroheme b which is cis-dihydroxylated at positions 5 and 6.


trans-heme d hydroxychlorin gamma-spirolactone

A metallochlorin that is ferroheme b which is hydroxylated at positions 5 and 6, and in which the resulting 6-hydroxy group undergoes formal condensation with the carboxy group of the 6-carboxyethyl group to afford the corresponding spirolactone in which the oxygen atoms at positions 5 and 6 are trans to each other.


ferriheme b(1-)

Ferriheme b carrying an overall charge of -1, caused by loss of a proton from each of the two carboxy groups.


ferriheme

Any iron(III)--porphyrin coordination complex.


ferriheme a

A ferriheme in which the 1-hydroxy group has S-configuration.


ferriheme a3

A ferriheme consisting of a tetraporphyrin derivative coordinated to a central iron.


A ferroheme having four carboxy groups and oxo groups on two of the pyrrole rings.


cadherin-related family member 1 isoform h2 (human)

A cadherin-related family member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96JP9-2.


cadherin-related family member 1 isoform h1 (human)

A cadherin-related family member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96JP9-1.


2-Amino-5-fluorobenzoic acid

An aminobenzoic acid that is anthranilic acid in which the hydrogen at position 5 on the phenyl ring is replaced by fluorine.


leukotriene A-4 hydrolase isoform h2 (human)

A leukotriene A-4 hydrolase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09960-2.


leukotriene A-4 hydrolase isoform 1 (human)

A leukotriene A-4 hydrolase isoform 1 that is encoded in the genome of human.


leukotriene A-4 hydrolase isoform h3 (human)

A leukotriene A-4 hydrolase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09960-3.


leukotriene A-4 hydrolase, initiator methionine removed form (human)

A leukotriene A-4 hydrolase (human) that has had the initiator methionine removed. UniProtKB:P09960, 2-611.


leukotriene A-4 hydrolase isoform h4 (human)

A leukotriene A-4 hydrolase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09960-4.


aggrecan core protein O-glycosylated 88 (human)

An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2258 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2258, MOD:00005~GNO:G43417UB.


phospholemman isoform 1 (human)

A phospholemman isoform 1 that is encoded in the genome of human.


phospholemman

A protein that is a translation product of the human FXYD1 gene or a 1:1 ortholog thereof.


phospholemman, signal peptide removed form (human)

A phospholemman (human) that has had the signal peptide removed. UniProtKB:O00168, 21-92.


WD repeat domain phosphoinositide-interacting protein 1 isoform 1 (human)

A WD repeat domain phosphoinositide-interacting protein 1 isoform 1 that is encoded in the genome of human.


transcription factor Sp1 isoform 1 cleaved 1 (human)

A transcription factor Sp1 isoform 1 cleaved 1 in human. UniProtKB:P08047-1, 65-785.


Y+L amino acid transporter 1

A protein that is a translation product of the human SLC7A7 gene or a 1:1 ortholog thereof.


14-3-3 protein beta/alpha isoform Long (human)

A 14-3-3 protein beta/alpha isoform 1 that is encoded in the genome of human.


14-3-3 protein beta/alpha isoform Short (human)

A 14-3-3 protein beta/alpha isoform 2 that is encoded in the genome of human.


pulmonary surfactant-associated protein A1

A protein that is a translation product of the human SFTPA1 gene or a 1:1 ortholog thereof.


pulmonary surfactant-associated protein A1 isoform h2 (human)

A pulmonary surfactant-associated protein A1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IWL2-2.


pulmonary surfactant-associated protein A1 isoform h1 (human)

A pulmonary surfactant-associated protein A1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IWL2-1.


pulmonary surfactant-associated protein A1, signal peptide removed form (human)

A pulmonary surfactant-associated protein A1 (human) that has had the signal peptide removed. UniProtKB:Q8IWL2, 21-248.


periodontal disorder

An inflammatory process of the gingival tissues and/or periodontal membrane of the teeth, resulting in an abnormally deep gingival sulcus, possibly producing periodontal pockets and loss of alveolar bone support.


chronic periodontitis

A chronic inflammatory process that affects the tissues that surround and support the teeth.


brevican core protein O-glycosylated 1 (human)

A brevican core protein (human) that has been O-glycosylated at the residue equivalent to Thr-384 of the amino acid sequence represented by UniProtKB:Q96GW7-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q96GW7-1, Thr-384, MOD:00005~GNO:G43417UB.


E3 ubiquitin-protein ligase RNF128 isoform 1 (human)

An E3 ubiquitin-protein ligase RNF128 isoform 1 that is encoded in the genome of human.


Vam6/Vps39-like protein isoform 1 (human)

A Vam6/Vps39-like protein isoform 1 that is encoded in the genome of human.


tissue-type plasminogen activator N-glycosylated 79 (human)

A tissue-type plasminogen activator (human) that has been N-glycosylated at the residue equivalent to Asn-483 of the amino acid sequence represented by UniProtKB:P00750-1, in which the glycan structure is represented by GlyTouCan:G02000AU. Example: UniProtKB:P00750-1, Asn-483, MOD:00160~GNO:G02000AU.


DNA-directed RNA polymerase I subunit RPA49 isoform h2 (human)

A DNA-directed RNA polymerase I subunit RPA49 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9GZS1-2.


DNA-directed RNA polymerase I subunit RPA49 isoform h1 (human)

A DNA-directed RNA polymerase I subunit RPA49 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9GZS1-1.


tyrosine-protein phosphatase non-receptor type 11 phosphorylated 1 (human)

A tyrosine-protein phosphatase non-receptor type 11 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-546 of the amino acid sequence represented by UniProtKB:Q06124. UniProtKB:Q06124, Tyr-546, MOD:00048.


CUB and zona pellucida-like domain-containing protein 1 isoform h3 (human)

A CUB and zona pellucida-like domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86UP6-3.


CUB and zona pellucida-like domain-containing protein 1 isoform h1 (human)

A CUB and zona pellucida-like domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86UP6-1.


CUB and zona pellucida-like domain-containing protein 1 isoform h2 (human)

A CUB and zona pellucida-like domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86UP6-2.


triggering receptor expressed on myeloid cells 2 sequence variant A196T (human)

A triggering receptor expressed on myeloid cells 2 sequence variant (human) that has a Thr residue at the position equivalent to Ala-196 of the amino acid sequence represented by UniProtKB:Q9NZC2-1. Example: UniProtKB:Q9NZC2-1, Ala-196, CHEBI:30013.


cartilage oligomeric matrix protein sequence variant D290N (human)

A cartilage oligomeric matrix protein (human) that has an Asn residue at the position equivalent to Asp-290 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-290, CHEBI:50347.


poly [ADP-ribose] polymerase 2 ADP-ribosylglutamate form (human)

A poly [ADP-ribose] polymerase 2 (human) that includes at least one ADP-ribosylated glutamic acid. UniProtKB:Q9UGN5, MOD:00300.


long-chain-fatty-acid--CoA ligase 6 isoform h7 (human)

A long-chain-fatty-acid--CoA ligase 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UKU0-7.


protein kinase C epsilon type isoform 1 (human)

A protein kinase C epsilon isoform 1 that is encoded in the genome of human.


polyazaalkane

Any azaalkane in which two or more carbons in the chain are replaced by nitrogen.


A spermidine in which four carbon atoms have been replaced by the (13)C isotope.


alkane-alpha,omega-diamine

A primary diamine that is ethane or a higher alkane in which a hydrogen of each of the terminal methyl groups has been replaced by an amino group. H2NCH2(CH2)nCH2NH2, where n = 0, 1, 2, etc.


tyrosine-protein kinase Fer

A protein that is a translation product of the human FER gene or a 1:1 ortholog thereof.


tyrosine-protein kinase Fer isoform 1 (human)

A tyrosine-protein kinase Fer (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16591-1.


tyrosine-protein kinase Fer isoform 3 (human)

A tyrosine-protein kinase Fer isoform 3 that is encoded in the genome of human.


tyrosine-protein kinase Fer isoform h2 (human)

A tyrosine-protein kinase Fer (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16591-2.


diamine acetyltransferase 1 isoform 1 (human)

A diamine acetyltransferase 1 isoform 1 that is encoded in the genome of human.


DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1 (human)

A DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1 that is encoded in the genome of human.


aminoglycoside phosphotransferase domain-containing protein 1

A protein that is a translation product of the human HYKK gene or a 1:1 ortholog thereof.


hydroxylysine kinase isoform h2 (human)

A hydroxylysine kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2RU49-2.


hydroxylysine kinase isoform h1 (human)

A hydroxylysine kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2RU49-1.


hydroxylysine kinase isoform h3 (human)

A hydroxylysine kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2RU49-3.


eIF-2-alpha kinase GCN2 isoform h2 (human)

An eIF-2-alpha kinase GCN2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9P2K8-2.


versican core protein O-glycosylated 128 (human)

A versican core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1734 of the amino acid sequence represented by UniProtKB:P13611-1, in which the glycan composition is represented by GlyTouCan:G88713AC. Example: UniProtKB:P13611-1, Thr-1734, MOD:00005~GNO:G88713AC.


serine/threonine-protein kinase PRKX

A protein that is a translation product of the human PRKX gene or a 1:1 ortholog thereof.


ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1 (human)

A ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1 in human. UniProtKB:P23443-1, Ser-441/Ser-447, MOD:00046|Thr-444, MOD:00047.


guanine nucleotide-binding protein G(t) subunit alpha-3 isoform 1 (human)

A guanine nucleotide-binding protein G(t) subunit alpha-3 isoform 1 that is encoded in the genome of human.


14 kDa phosphohistidine phosphatase isoform h1 (human)

A 14 kDa phosphohistidine phosphatase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRX4-1.


guanylyl cyclase-activating protein 2, initiator methionine removed form (human)

A guanylyl cyclase-activating protein 2 (human) that has had the initiator methionine removed. UniProtKB:Q9UMX6, 2-200.


guanylyl cyclase-activating protein 2

A protein that is a translation product of the human GUCA1B gene or a 1:1 ortholog thereof.