Ponatinib hydrochloride

The hydrochloride salt of ponatinib. It is a potent pan inhibitor of tyrosine kinases, active in all single resistance ABL kinase mutations including the T315l mutation. It is approved for the treatment of chronic myeloid leukemia.


Stage II Rectosigmoid Cancer AJCC v7

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

Stage II includes: IIA (T3, N0, M0); IIB (T4a, N0, M0); IIC (T4b, N0, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


D-phenylalanine

The D-enantiomer of phenylalanine.


The (R)-enantiomer of bethanechol chloride.


Recurrent Rectal Cancer

The reemergence of rectal carcinoma after a period of remission.


Rectal adenocarcinoma recurrent

The reemergence of rectal adenocarcinoma after a period of remission.


polyatomic cation

A cation consisting of more than one atom.


A lysophosphatidylcholine(0:0/16:1) in which the 2-acyl group is specified as (9Z)-hexadecenoyl.


phosphocholines

Any compound having phosphocholine as part of its structure.


phosphatidylcholine 38:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 2 double bonds.


phosphatidylcholine O-30:1

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 30 carbons and 1 double bond.


phosphatidylcholine (P-36:2)

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the unspecified alk-1-enyl and acyl groups at positions 1 and 2 contain 36 carbon atoms in total with 2 additional double bonds in the acyl moiety.


phosphatidylcholine

A glycerophosphocholine that is glycero-3-phosphocholine bearing two acyl substituents at positions 1 and 2.


phosphatidylcholine 42:8

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 8 double bonds.


The conjugate base of a 1,2-diacyl-sn-glycero-3-phosphocholine compound formed by deprotonation of the phosphate OH group.


lysophosphatidylcholine 14:0

A lysophosphatidylcholine in which the remaining acyl group is specified as tetradecanoyl (myristoyl). If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine.  If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


sphingomyelin 42:2

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 42 with 2 double bonds.


A phosphatidylcholine 38:3 in which the acyl groups at positions 1 and 2 are specified as stearoyl (octadecanoyl) and icosatrienoyl respectively.


sphingomyelin 36:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 36 with 1 double bond.


sphingomyelin 42:0

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 42 with 0 double bonds.


A 1-acyl-sn-glycero-3-phosphocholine in which the 1-acyl group contains 18 carbons and 2 double bonds.


An alkyl,acyl-sn-glycero-3-phosphocholine in which unspecified acyl and alkyl groups are located at positions 1 and 2 respectively.


Benzododecinium

A quaternary ammonium ion obtained by methylation of N-benzyl-N-methyldodecan-1-amine.


A 1,2-diacyl-sn-glycero 3-phosphocholine in which the acyl group at position 1 is unspecified while that at position 2 is specified as arachidonoyl


phosphatidylcholine 38:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 1 double bond.


A 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphocholine in which the 2-acyl substituent is specified as oleoyl.


A 1-acyl-sn-glycero-3-phosphocholine in which the 1-acyl group contains 20 carbons and 4 double bonds.


Any member of the class of lysophosphatidylcholines which has a free hydroxy group at the 1-position of the glycerol moiety.


A 1,2-diacyl-sn-glycero-3-phosphocholine where the acyl group at position 1 is unspecified while the acyl group at position 2 is palmitoleoyl.


lysophosphatidylcholine 20:5

A lysophosphatidylcholine in which the acyl group contains 20 carbons and 5 double bonds. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


A lysophosphatidylcholine 22:6 in which the docosahexaenoyl group is located at position 1.


lysophosphatidylcholine 18:3

An acyl-sn-glycero-3-phosphocholine in which the acyl group contains 18 carbons with 3 double bonds. If R1 is an acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is an acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


lysophosphatidylcholine 16:0

A lysophosphatidylcholine in which the acyl group has a fully saturated C16 chain and is attached to the glycero moiety at either position 1 or 2.


lysophosphatidylcholine 22:4

A lysophosphatidylcholine in which the acyl group (position not specified) contains 22 carbons and 4 double bonds.


A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the alkenyl group has Z geochemistry.


A sphingomyelin in which the total number of carbons in the fatty acyl group is 22 with 1 double bond.


phosphatidylcholine 36:3

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 3 double bonds.


A sphingomyelin d18:1 in which the ceramide N-acyl group contains 22 carbons, 1 hydroxy group and 2 double bonds.


phosphatidylcholine 42:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 4 double bonds.


phosphatidylcholine (P-34:2)

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the unspecified alk-1-enyl and acyl groups at positions 1 and 2 contain 34 carbon atoms in total with 2 additional double bonds in the acyl moiety.


phosphatidylcholine 40:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total with 1 double bond.


A sphingomyelin d18:1 in which the ceramide N-acyl group contains 22 carbons, 1 hydroxy group and 1 double bond.


phosphatidylcholine O-34:2

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 34 carbons and 2 double bonds.


phosphatidylcholine O-38:6

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 38 carbons and 6 double bonds.


The ammonium betaine of a 2-acyl-sn-glycero-3-phosphocholine arising from deprotonation of the phosphate OH; major species at pH 7.3.


phosphatidylcholine 36:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total and 2 double bonds.


A 2-acyl-sn-glycero-3-phosphocholine in which the 2-acyl group contains 16 carbons and is fully saturated.


phosphatidylcholine O-42:0

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 42 carbons and 0 double bonds.


phosphatidylcholine 42:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 5 double bonds.


phosphatidylcholine O-38:5

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 38 carbons and 5 double bonds.


A sphingomyelin having sphinganine as the sphingoid component.


Edelfosine, (S)-

A 1-octadecyl-2-methylglycero-3-phosphocholine that is the (S)-enantiomer of edelfosine.


sphingomyelin 34:0

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 34 with 0 double bonds.


phosphatidylcholine O-36:0

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 36 carbons and 0 double bonds.


phosphatidylcholine O-42:3

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 42 carbons and 3 double bonds.


monoalkylglycerophosphocholine

A glycerophosphocholine that is glycero-3-phosphocholine bearing a single alkyl substituent at an unspecified position (sn-1, sn-2, or sn-3).


phosphatidylcholine 40:10

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the two acyl groups contain a total of 40 carbons and 10 double bonds.


The ammonium betaine formed from 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine by deprotonation of the phosphate OH group.


phosphatidylcholine O-38:0

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 38 carbons and 0 double bonds.


phosphatidylcholine 34:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 34 carbons in total with 1 double bond.


phosphatidylcholine 40:7

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total with 7 double bonds.


An alkyl,acyl-sn-glycero-3-phosphocholine in which unspecified alkyl and acyl groups are located at positions 1 and 2 respectively.


A phosphatidylcholine 36:4 in which the acyl groups at positions 1 and 2 are octadecadienoyl with double bonds at unspecified positions.


phosphatidylcholine 42:9

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 9 double bonds.


A 1-acyl-2-alkyl-sn-glycero-3-phosphocholine in which the 2-alkyl moiety can be any alk-1-enyl group.


phosphatidylcholine 34:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 34 carbons in total with 2 double bonds.


Any member of the class of lysophosphatidylcholines which has a free hydroxy group at the 2-position of the glycerol moiety.


phosphatidylcholine O-30:0

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 30 carbons and 0 double bond.


lysophosphatidylcholine 18:4

A lysophosphatidylcholine in which the acyl group (position not specified) contains 18 carbons and 4 double bonds.


lysophosphatidylcholine 22:1

A lysophosphatidylcholine in which the remaining acyl group contains 22 carbons and 1 double bond. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


A 2-acyl-1-alkyl-sn-glycero-3-phosphocholine where the 2-O-acyl component is specifed as arachidonoyl.


sphingomyelin 36:2

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 36 with 2 double bonds.


lysophosphatidylcholine 15:0

An acyl-sn-glycero-3-phosphocholine in which the acyl group contains fifteen carbons with no double bonds and is attached to the glycero moiety at either position 1 or 2.


lysophosphatidylcholine 18:0

A lysophosphatidylcholine in which the acyl group has a fully saturated C18 chain and is attached to the glycero moiety at either position 1 or 2.


sphingomyelin 30:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 30 with 1 double bond.


phosphatidylcholine 33:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups specified at C-1 and C-2 contain 33 carbons in total with 1 double bond.


A lysophosphatidylcholine with defined stereochemistry where the position of the acyl group is unknown.


The conjugate base of a 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine compound formed by deprotonation of the phosphate OH group.


sphingomyelin 34:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 34 with 1 double bond.


Lysophosphatidylcholine

An acylglycerophosphocholine resulting from partial hydrolysis of a phosphatidylcholine, which removes one of the fatty acyl groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.


lysophosphatidylcholine 20:0

A lysophosphatidylcholine in which the remaining acyl group contains 20 carbons and 0 double bonds. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


phosphatidylcholine P-36:5

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the alk-1-enyl and acyl groups at positions 1 and 2 contain 36 carbon atoms in total with 5 additional double bonds.


phosphatidylcholine O-40:6

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 40 carbons and 6 double bonds.


phosphatidylcholine 42:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 1 double bond.


A glycerophosphocholine that is sn-glycero-3-phosphocholine in which positions 1 and 2 are substituted by unspecified acyl and alkyl groups, and in which the positions of the acyl and alkyl groups are also unspecified.


A monoalkylglycerophosphocholine in which the alkyl group may be attached to the sn-1 or sn-3 position.


A sphingomyelin 41:2 obtained by formal condensation of the carboxy group of any tetracosenoic acid with the amino group of hexadecasphingosine-1-phosphocholine.


lysophosphatidylcholine 22:2

A lysophosphatidylcholine in which the remaining acyl group contains 22 carbons and 2 double bonds. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


sphingomyelin d18:1/16:0

A sphingomyelin d18:1 in which the fatty acyl group contains 16 carbons and is fully saturated.


phosphatidylcholine 28:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 28 carbons in total with 2 double bonds.


A glycerophosphocholine having an unspecified acyl group attached at the 2-position.


phosphatidylcholine 33:0

A phosphatidylcholine in which the two acyl groups contain a total of 33 carbons and no double bonds.


An ammonium ion that is the conjugate acid of pyridoxamine arising from selective protonation of the primary amino group; major species at pH 7.3.


phosphatidylcholine 40:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total with 5 double bonds.


(S)-Bethanechol

The (S)-enantiomer of bethanechol.


lysophosphatidylcholine 22:6

An acyl-sn-glycero-3-phosphocholine in which the acyl group (position not specified) contains 22 carbons with 6 double bonds.


A glycerophosphocholine that is glycero-3-phosphocholine bearing a single alkenyl group located at position 1.


phosphatidylcholine 30:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 30 carbons in total with 2 double bonds.


phosphatidylcholine 42:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 0 double bonds.


A lysophosphatidylcholine in which the acyl group (position not specified) is linoleoyl.


phosphatidylcholine O-44:5

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 44 carbons and 5 double bonds.


A lysophosphatidylcholine 16:1 in which the acyl group is specified as (9Z)-hexadecenoyl and is located at either position 1 or 2.


A 1,2-diacyl-sn-glycero-3-phosphocholine where the acyl group at position 1 is unspecified while the acyl group at position 2 is palmitoyl.


lysophosphatidylcholine (22:5/0:0)

A lysophosphatidylcholine 22:5 in which the acyl group is located at position 1.


phosphatidylcholine 34:3

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 34 carbons in total with 3 double bonds.


sphingomyelin 40:2

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 40 with 2 double bonds.


A glycero-3-phosphocholine compound having an alk-1-enyl substituent at the 1-position and an acyl substituent at the 2-position.


phosphatidylcholine 38:6

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 6 double bonds.


phosphatidylcholine O-34:0

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 34 carbons and 0 double bonds.


A glycerophosphocholine that is sn-glycero-3-phosphocholine bearing a single alkyl substituent at an unspecified position (either R(1) = H, R(2) = alkyl or R(1) = alkyl, R(2) = H).


phosphatidylcholine 38:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 4 double bonds.


phosphatidylcholine 32:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 1 double bond.


An sn-glycero-3-phosphocholine substituted at the 1-oxygen by an alk-1-enyl group.


lysophosphatidylcholine 22:5

A lysophosphatidylcholine in which the acyl group (position not specified) contains 22 carbons with 5 double bonds.


A sphingomyelin d18:1 in which the ceramide N-acyl group contains 16 carbons, 1 hydroxy group and 1 double bond.


phosphatidylcholine (20:3/22:6)

A phosphatidylcholine 42:9  in which the fatty acyl groups at positions 1 and 2 are specified as C20:3 and C22:6 respectively.


sphingomyelin d18:1/18:1

A sphingomyelin d18:1 in which the fatty acyl group contains 16 carbons and 1 double bond


phosphatidylcholine 32:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 2 double bonds.


phosphatidylcholine 34:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 34 carbons in total with 0 double bonds.


phosphatidylcholine 36:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 4 double bonds.


phosphatidylcholine 37:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 37 carbons in total with 5 double bonds.


phosphatidylcholine 29:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at positions 1 and contain a total of 29 carbons and no double bonds.


sphingomyelin 32:1

A sphingomyelin in which the total number of carbons in the sphingoid base (R1) and fatty acyl (R2) groups is 32 with 1 double bond.


phosphatidylcholine 34:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 34 carbons in total with 4 double bonds.


phosphatidylcholine 36:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 1 double bond.


Tiquizium

A member of the class of quinolizines that is trans-5-methyloctahydro-2H-quinolizinium which is substituted by a di(thiophen-2-yl)methylidene group at position 3. Its bromide salt is used as an antispasmodic drug.


lysophosphatidylcholine 16:1

An lysophosphatidylcholine in which the acyl group is hexadecenoyl (position of double bond not specified). If R1 is hexadecenoyl and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is hexadecenoyl then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


lysophosphatidylcholine 20:1

A lysophosphatidylcholine in which the remaining acyl group contains 20 carbons and 1 double bond. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


phosphatidylcholine (18:2/22:6)

A phosphatidylcholine 40:8 in which the fatty acyl groups at positions 1 and 2 are specified as C18:2 and C22:6 respectively.


phosphatidylcholine 36:6

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 6 double bonds.


A phosphatidylcholine 36:1 in which the acyl groups aspecified at positions 1 and 2 are octadecanoyl and octadecenoyl (double bond at unspecified position) respectively.


phosphatidylcholine 38:8

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the two acyl groups contain a total of 38 carbons and 8 double bonds.


phosphatidylcholine 31:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the two acyl groups contain a total of 31 carbons and no double bonds.


A phosphatidylcholine having an alpha-linolenoyl at sn-1 and a fatty acyl chain of unknown composition at sn-2. Major species at pH 7.3.


phosphatidylcholine 38:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 5 double bonds.


lysophosphatidylcholine 20:2

A lysophosphatidylcholine in which the remaining acyl group contains 20 carbons and 2 double bonds. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


lysophosphatidylcholine 17:0

An  lysophosphatidylcholine in which the acyl group contains seventeen carbons and no double bonds. If R1 is an acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphoethanolaminecholine. If R1 is a hydrogen and R2 is an acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


lysophosphatidylcholine (18:1/0:0)

A lysophosphatidylcholine 18:1 in which the acyl group is located at position 1.


A glycerophosphocholine that consists of L-alpha-glycerophosphocholine carrying an unspecified alkyl substituent at position 1.


A phosphatidylcholine 36:2 in which the acyl group both at positions 1 and 2 is octadecenoyl with double bond at unspecified position.


A phosphatidylcholine having a linoleoyl at sn-1 and a fatty acyl chain of unknown composition at sn-2. Major species at pH 7.3.


glycerophosphocholine

The glycerol phosphate ester of a phosphocholine. A nutrient with many different roles in human health.


A phosphatidylcholine 32:1 in which one acyl group has 16 carbons and is fully saturated while the other has 16 carbons and 1 double bond (position not specified).


sphingomyelin 41:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 41 with 1 double bond.


A 2-acyl-sn-glycero-3-phosphocholine in which the 2-acyl group contains 18 carbons and is fully saturated.


phosphatidylcholine 35:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 35 carbons in total with 5 double bonds.


lysophosphatidylcholine 20:4

An acyl-sn-glycero-3-phosphocholine in which the remaining acyl group (position not specified) contains 20 carbons with 4 double bonds.


N-Trimethyllysine

An alpha-amino-acid cation that is the N(6)-trimethyl derivative of L-lysine.


phosphatidylcholine (P-38:4)

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the unspecified alk-1-enyl and acyl groups at positions 1 and 2 contain 38 carbon atoms in total with 4 additional double bonds in the acyl moiety.


Aclidinium

A carboxylic ester obtained by formal condensation between the carboxy group of 2-hydroxy(di-2-thienyl)acetic acid and the hydroxy group of N-(3-phenoxypropyl)-3-quinuclidinol. Used as its bromide salt for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD).


A 1-O-(alk-1-enyl)-sn-glycero-3-phosphocholine in which the alkenyl group has Z geochemistry.


phosphatidylcholine 28:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 28 carbons in total with 0 double bonds.


lysophosphatidylcholine (P-16:0/0:0)

A 1-O-(alk-1-enyl)-sn-glycero-3-phosphocholine in which the alk-1-enyl group contains 16 carbons and no additional double bonds.


phosphatidylcholine 30:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 30 carbons in total with 0 double bonds.


phosphatidylcholine 38:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 0 double bonds.


lysophosphatidylcholine 18:1

A lysophosphatidylcholine in which the remaining acyl group (position not specified) contains 18 carbons with 1 double bond.


phosphatidylcholine 29:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 28 carbons in total with 1 double bond.


sphingomyelin 41:2

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 41 with 2 double bonds.


ammonium ion derivative

A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).


lysophosphatidylcholine 18:2

A lysophosphatidylcholine in which the acyl group (position not specified) contains 18 carbons and 2 double bonds.


phosphatidylcholine 40:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total with 2 double bonds.


phosphatidylcholine O-44:3

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 44 carbons and 3 double bonds.


phosphatidylcholine 30:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 30 carbons in total with 1 double bond.


A sphingomyelin in which the total number of carbons in the fatty acyl group is 26 with 1 double bond.


phosphatidylcholine 36:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total and 0 double bonds.


phosphatidylcholine 32:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 0 double bonds.


phosphatidylcholine 35:3

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 35 carbons in total with 3 double bonds.


A primary ammonium ion that is the conjugate acid of thiamine(1+) resulting from the protonation of the primary amino group.


A 1,2-diacyl-sn-glycero-3-phosphocholine in which the 1-acyl group is specified as palmitoyl.


phosphatidylcholine O-32:2

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 32 carbons and 2 double bonds.


A sphingomyelin in which the total number of carbons in the fatty acyl group is 24 with 1 double bond.


sphingomyelin d18:1

Any sphingomyelin having sphingosine as the sphingoid component.


lysophosphatidylcholine 20:3

A lysophosphatidylcholine in which the acyl group contains 20 carbons with 3 double bonds. If R1 is an acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is an acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


phosphatidylcholine P-40:6

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the alk-1-enyl and acyl groups contain a total of 40 carbon atoms with 6 additional double bonds.


phosphatidylcholine 32:3

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 3 double bonds.


A glycerophosphocholine that is glycero-3-phosphocholine carrying unspecified alk-1-enyl and acyl groups at positions 1 and 2 respectively. Major species at pH 7.3.


A lysophosphatidylcholine 20:1 in which the acyl group is located at position 1.


phosphatidylcholine 42:6

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 6 double bonds.


sphingomyelin 38:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 38 with 1 double bond.


phosphatidylcholine O-40:0

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 40 carbons and 0 double bonds.


sphingomyelin 44:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 44 with 1 double bond.


(R)-Bethanechol

The (R)-enantiomer of bethanechol.


acylcholine

A choline ester formed from choline and a carboxylic acid.


phosphatidylcholine 33:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 33 carbons in total with 2 double bonds.


phosphatidylcholine 36:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 5 double bonds.


lysophosphatidylcholine 24:0

A lysophosphatidylcholine in which the remaining acyl group (position not specified) contains 24 carbons and 0 double bonds.


A 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine in which the 2-acyl group has 20 carbons and 3 double bonds.


A glycerophosphocholine that is glycero-3-phosphocholine carrying one alkyl and one acyl group in unspecified positions. Major species at pH 7.3.


sphingomyelin 42:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 42 with 1 double bond.


An N-acylsphinganine-1-phosphocholine obtained by formal condensation of the carboxy group of any octadecenoic acid with the amino group of sphinganine-1-phosphocholine.


lysophosphatidylcholine 24:1

A lysophosphatidylcholine in which the remaining acyl group (position not specified) contains 24 carbons and 1 double bond.


lysophosphatidylcholine 20:3/0:0

A 1-O-acyl-sn-glycero-3-phosphocholine in which the acyl group at C-1 contains 20 carbons and 3 double bonds.


phosphatidylcholine (18:0/22:5)

A 1,2-diacyl-sn-glycero-3-phosphocholine in which one acyl group has 18 carbons and is fully saturated while the other has 22 carbons and 5 double bonds.


sphingomyelin 44:2

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 44 with 2 double bonds.


sphingomyelin 40:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 40 with 1 double bond.


phosphatidylcholine 40:8

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total with 8 double bonds.


An alkylacylglycero-3-phosphocholine in which the alkyl and acyl groups are located at positions 1 and 2 respectively. Major species at pH 7.3.


phosphatidylcholine 38:3

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons with 3 double bonds.


A 1-(alk-1-enyl)-2-oleoyl-sn-glycero-3-phosphocholine in which the alk-1-enyl group has Z geochemistry.


phosphatidylcholine O-38:4

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 38 carbons and 4 double bonds.


A sphingomyelin d18:1 in which the ceramide N-acyl group contains 24 carbons, 1 hydroxy group and 1 double bond.


A 1-acyl-2-alkyl-sn-glycero-3-phosphocholine in which the acyl and alkyl groups at positions 1 and 2 are specified respectively as arachidonoyl and palmityl.


A 1-octadecyl-2-methylglycero-3-phosphocholine that is the (R)-enantiomer of edelfosine.


phosphatidylcholine (22:4/20:4)

A phosphatidylcholine 42:8 in which the fatty acyl groups at positions 1 and 2 are specified as C22:4 and C20:4 respectively. The positions of the double bonds are unspecified.


phosphatidylcholine 40:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total and 4 double bonds.


cholines

A quaternary ammonium ion based on the choline ion and its substituted derivatives thereof.


The ammonium betaine of a 1-O-acyl-sn-glycero-3-phosphocholine arising from deprotonation of the phosphate OH; major species at pH 7.3.


lysophosphatidylcholine 14:1

A lysophosphatidylcholine in which the remaining acyl group contains 14 carbons and 1 double bond. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


phosphatidylcholine O-34:1

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 34 carbons and 1 double bond.


lysophosphatidylcholine (22:4/0:0)

A lysophosphatidylcholine 22:4 in which the docosatetraenoyl group is located at position 1.


A sphingomyelin  d18:1 in which the ceramide N-acyl group contains 14 carbons, 1 hydroxy group and 1 double bond.


phosphatidylcholine O-30:2

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 30 carbons and 2 double bonds.


phosphatidylcholine 37:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 37 carbons in total with 4 double bonds.


sphingomyelin

Any of a class of phospholipids in which the amino group of a sphingoid base is in amide linkage with one of several fatty acids, while the terminal hydroxy group of the sphingoid base is esterified to phosphorylcholine.


phosphatidylcholine 40:6

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the two acyl groups contain forty carbons in total with six double bonds.


quaternary ammonium ion

A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.


Stage IIIB Cervical Cancer FIGO 2018

Cervical carcinoma with extension to the pelvic wall and/or hydronephrosis or nonfunctioning kidney (unless known to be due to another cause). (FIGO 2018)


Extramedullary Disease in Plasma Cell Myeloma Involving the Liver

Infiltration of the hepatic sinusoids by malignant (clonal) plasma cells in patients with history of plasma cell myeloma.


A secondary amino compound that is ammonia in which nitrogen is substituted by a 1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl group and a 2-(2-ethoxyphenoxy)ethyl group.


alpha-D-galactoside

Any D-galactoside having alpha-configuration at its anomeric centre.


icosatetraenoic acid

A 20-carbon, polyunsaturated fatty acid having four double bonds at unspecified positions.


Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.


Magnesium chloride (MgCl2) hydrate (1:6)

A hydrate that is the hexahydrate form of magnesium dichloride.


paraben

A 4-hydroxybenzoate ester in which the esterifying alcohol is an alkanol (in diagram, R = alkyl). Commonly used as preservatives in cosmetic and pharmaceutical products.


A 3beta-hydroxy steroid that is cathasterone which is lacking the oxo substituent at position 6.


Resectable Colon Carcinoma

Colon carcinoma that is amenable to surgical resection.


Localized Resectable Adult Hepatocellular Carcinoma

A localized hepatocellular carcinoma that occurs during adulthood and it is amenable to surgical resection.


Carcinoma liver resectable

A hepatocellular carcinoma that is amenable to surgical resection.


Resectable Colorectal Carcinoma

Colorectal carcinoma that is amenable to surgical resection.


A 4-hydroxy-D-proline in which the hydroxy group at position 4 has S-configuration.


An androstanoid that is testosterone substituted at C2  by a hydroxy group with undefined stereochemistry.


An androstanoid that is testosterone carrying an additional hydroxy substituent at the 2beta-position.


Tubocapsanolide F

A  withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 17 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Tubocapsicum anomalum, it exhibits cytotoxic activity.


allylamine antifungal drug

An organonitrogen compound that contains an amino group that is attached to a carbon which is itself attached to an olefinic carbon and which has been used as an antifungal drug.


Terbinafine hydrochloride

A hydrochloride obtained by reaction of terbinafine with one molar equivalent of hydrogen chloride.


A hydrochloride salt resulting from the formal reaction of equimolar amounts of thiocyclam and hydrogen chloride. A nicotinic acetylcholine receptor agonist used as a broad-spectrum insecticide. Not approved for use within the European Union.


A 17-oxo steroid that is 5alpha-androstan-17-one substituted by a beta-hydroxy group at positions 3 and an alpha-hydroxy group at position 7.


Stage IA Cervical Cancer FIGO 2018

Invasive cervical carcinoma that can be diagnosed only by microscopy, with maximum depth of invasion less than 5 mm. (FIGO 2018)


Stage IA2 Cervical Cancer FIGO 2018

Cervical carcinoma with measured stromal invasion equal or more than 3 mm and less than 5 mm in depth. (FIGO 2018)


Stage IA1 Cervical Cancer FIGO 2018

Cervical carcinoma with measured stromal invasion less than 3 mm in depth. (FIGO 2018)


Quinoxaline

A naphthyridine in which the nitrogens are at positions 1 and 4.


A quinoxaline derivative  that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kgamma, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis.


An androstanoid that is 5alpha-dihydrotestosterone carrying an additional hydroxy susbstituent at position 19.


Rilpivirine hydrochloride

A hydrochloride obtained by reaction of rilpivirine with one equivalent of hydrochloric acid. Used for treatment of HIV.


Refractory Endometrial Dedifferentiated Carcinoma

Endometrial dedifferentiated carcinoma that is resistant to treatment.


Calciumchloridehexahydrate

A hydrate that is the hexahydrate form of calcium chloride.


Calcium dihydrate dichloride

A hydrate that is the dihydrate form of calcium chloride.


Stage IVB Rectal Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis.  (AJCC 8th ed.)


hexose phosphate

A phospho sugar that is formally obtained from a hexose.


fructose 6-phosphate

A ketohexose monophosphate consisting of fructose having a phosphate group located at the 6-position.


D-aldohexose 6-phosphate

Any D-aldose having a six-carbon chain with a phosphate group at C-6.


D-fructose 6-phosphate

A ketohexose monophosphate that is D-fructose having a phosphate substituent at position 6. It is an important intermediate in the carbohydrate metabolism.


D-Galactopyranose 1-phosphate

A D-galactose phosphate that consists of  D-galactopyranose having a single phospho substituent located at the 1-position. It is an intermediate obtained during the the galactose metabolism.


D-hexose phosphate

Any mono-phosphorylated D-hexose having a chain of six carbon atoms in the molecule.


tagatose 6-phosphate

A  ketohexose monophosphate that is tagatose attached to a phosphate group at position 6.


D-fructose 1,6-bisphosphate

A ketohexose bisphosphate that is D-fructose substituted by phosphate groups at positions 1 and 6. It is an intermediate in the glycolysis metabolic pathway.


A D-tagatofuranose 6-phosphate with a beta-configuration at the anomeric position.


A D-glucopyranose 6-phosphate where alpha-D-glucose is the sugar component.


alpha-D-hexose 1-phosphates

Any hexose-1-phosphate which has D configuration at position 5 and alpha-configuration at the anomeric centre.


D-mannose 6-phosphate

A mannose phosphate in which the phosphate group is attached to position 6.


D-Mannose 1-phosphate

A mannose phosphate that is D-mannose carrying a phosphate group at position 1.


D-fructofuranose 1-phosphate

The furanose form of D-fructose 1-phosphate.


D-Glucose 6-phosphate

A D-glucose monophosphate in which the phosphate group is attached to position 6.


D-fructofuranose 2,6-bisphosphate

A ketohexose bisphosphate that is D-fructofuranose carrying phosphate groups at positions 2 and 6.


alpha-D-tagatofuranose 6-phosphate

A D-tagatofuranose 6-phosphate with an alpha-configuration at the anomeric position.


D-fructose 1-phosphate

The D-enantiomer of fructose 1-phosphate.


Mannose 6-phosphate

The pyranose form of D-mannose 6-phosphate.


fructose 1-phosphate

A ketohexose monophosphate consisting of fructose having a phosphate group located at the 1-position


D-tagatose 1,6-bisphosphate

A ketohexose bisphosphate that is D-tagatose carrying phosphate groups at positions 1 and 6.


D-hexopyranose 6-phosphate

Any D-hexose 6-phosphate in which the hexose is in the pyranose form.


Glucose 1-phosphate

A D-glucose monophosphate in which the phosphate group is located at position 1.


D-fructofuranose 1,6-bisphosphate

The furanose form of D-fructose 1,6-bisphosphate.


Cervical Mucinous Adenocarcinoma, Not Otherwise Specified

A cervical mucinous adenocarcinoma in which more than 50% of malignant cells contain intracytoplasmic mucin. There is no evidence of gastric, intestinal, or signet ring cell differentiation.


glycerolipid

Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.


phosphatidylethanolamine

A class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxy group of ethanolamine.


A monoglyceride in which the acyl substituent is located at position 1.


A 3-sn-glycerophosphoserine compound having acyl substituents at the 1- and 2-hydroxy positions.


A 3-sn-phosphatidyl-L-serine in which the 1- and 2-acyl groups are octadecanoyl and octadecadienoyl respectively.


monoacylglycerol 16:0

A monoglyceride in which the acyl group contains a total of 16 carbon atoms and 0 double bond.


phosphatidylethanolamine 36:0

A phosphatidylethanolamine in which the two acyl groups contain a total of 36 carbons and no double bonds.


phosphatidylinositol phosphate

Any member of the phosphoinositide family of compounds, of which seven occur naturally.


A phosphatidylethanolamine in which the phosphatidyl acyl group at C-1 and C-2 is stearoyl.


monoradylglycerol

Any lipid that is glycerol bearing a single acyl, alkyl or alk-1-enyl substituent at an unspecified position.


An optically active form of phosphatidylethanolamine having R-configuration.


lysophosphatidylethanolamine 20:3

An acyl-sn-glycero-3-phosphoethanolamine in which the acyl group contains twenty carbons with three double bonds and is attached to the glycero moiety at either position 1 or 2.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl group at position 1 is unspecified while that at position 2 is specified as myristoyl (tetradecanoyl).


phosphatidylserine 40:5

A 3-sn-phosphatidyl-L-serine in which the two acyl groups contain a total of 40 carbon atoms and 5 double bonds.


A diacylglycerolipid where the fatty acyl at sn-1 has a saturated bond between carbons 1 and 2, the glycerolipid part is unkown, R3 can be an H or a phospholipid.


A triglyceride where at least one of R1, R2 or R3 is a linoleoyl group. Formula is C23H36O6R2


monoacylglycerol 22:5

A monoglyceride in which the acyl groups contain a total of 22 carbons and 5 double bonds.


A 3-sn-phosphatidyl-L-serine in which the 1- and 2-acyl groups are octadecenoyl groups.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl group at position 1 is unspecified while that at position 2 is specified as palmitoyl (hexadecanoyl).


triacylglycerol 64:16

A triglyceride in which the three acyl groups contain a total of 64 carbons and 16 double bonds.


1-lysophosphatidic acid

Any member of the class of lysophosphatidic acids which has a free hydroxy group at the 1-position of the glycerol moiety.


An ether lipid consisting of glycerol substituted at position 2 by an acetyl group and at position 1 by an unspecified alkyl group.


A lysophosphatidylethanolamine 22:4 in which the acyl group is located at position 1.


triacylglycerol 46:1

A triglyceride in which the three acyl groups contain a total of 46 carbons and 1 double bond.


phosphatidylethanolamine 37:2

A phosphatidylethanolamine in which the two acyl groups contain a total of 37 carbons and 2 double bonds.


phosphatidylethanolamine 44:8

A phosphatidylethanolamine in which the two acyl groups contain a total of 44 carbons and 8 double bond.


monoacylglycerol phosphate

Derivatives of phosphoglycerols which have only one of the alcohol groups of the glycerol backbone ester-linked with a fatty acid.


An acyl-sn-glycero-3-phosphate in which a single acyl substituent is located at position 2.


1-acylglycerol 18:2

A 1-monoglyceride in which the acyl group contains 18 carbons and 2 double bonds.


2-acylglycerol 20:5

A 2-monoglyceride in which the acyl group contains 20 carbons and 5 double bonds.


CDP-diacylglycerol

A CDP-glycerol having unspecified acyl groups (most commonly fatty acyl groups) at the 1- and 2-positions.


triradylglycerol

A glycerol compound having one of three possible substituent groups - either acyl, alkyl, or alk-1-enyl - at each of the three possible positions sn-1, sn-2 or sn-3. has functional parent glycerol (CHEBI:17754), children: triglyceride (CHEBI:17855). Parent: is_a glycerolipid (CHEBI:35741)


triacylglycerol 52:7

A triglyceride in which the three acyl groups contain a total of 52 carbons and 7 double bonds.


phosphatidylserine 36:1

A 3-sn-phosphatidyl-L-serine in which the two acyl groups contain a total of 36 carbon atoms and 1 double bond.


lysophosphatidylethanolamine 20:1

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 20 carbons and 1 double bond.


phosphatidylethanolamine (18:1/22:6)

A phosphatidylethanolamine 40:7 in which the acyl group at C-1 contains 18 carbons and 1 double bond while that at C-2 contains 22 carbons and 6 double bonds.


1-acylglycerol 22:5

A 1-monoglyceride in which the acyl group contains 22 carbons and 5 double bonds.


monoacylglycerol 18:2

A monoglyceride in which the acyl groups contain a total of 18 carbons and two double bonds.


monoacylglycerol 20:4

A monoglyceride in which the acyl group contains a total of 20 carbon atoms and 4 double bonds.


glyceride

Any ester resulting from the condensation of one or more of the hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


A 3-sn-phosphatidyl-L-serine in which the 1- and 2-acyl groups are octadecanoyl and octadecenoyl respectively.


phosphatidylserine 36:4

A 3-sn-phosphatidyl-L-serine in which the two acyl groups contain a total of 36 carbon atoms and 4 double bonds.


alkyldiacylglyceride

A triradylglycerol with a single alkyl substituent and two acyl substituents at unspecified positions.


triacylglycerol 50:0

A triglyceride in which the three acyl groups contain a total of 50 carbons and 0 double bonds.


glycerophosphoinositol phosphate

Any glycerophosphoinositol bearing one or more additional phospho substituents on the inositol ring.


glycerophosphoinositol

Any glycerophospholipid having the polar alcohol inositol esterified to the phosphate group at the sn-3 position of the glycerol backbone.


A plasmalogen of unkown fatty acid composition and where the glycerolipid is not defined, R3 can be H or a phospholipid.


A 1-monoglyceride that has palmitoyl as the acyl group. A natural product found in Neolitsea daibuensis.


lysophosphatidylethanolamine 22:6

An acyl-sn-glycero-3-phosphoethanolamine in which the acyl group contains twenty-two carbons with six double bonds and is attached to the glycero moiety at either position 1 or 2.


2-acylglycerol 18:0

A 2-monoglyceride in which the acyl group contains 18 carbons and is fully saturated.


monoacylglycerol 20:5

A monoglyceride in which the acyl group contains a total of 20 carbon atoms and 5 double bonds at unspecified positions.


phosphatidylethanolamine 40:6

A phosphatidylethanolamine in which the two acyl groups contain a total of 40 carbons and 6 double bonds.


phosphatidylglycerol 32:1

A phosphatidylglycerol in which the two acyl groups contain a total of 32 carbon atoms and 1 double bond.


phosphatidylinositol 36:4

A 1-phosphatidyl-1D-myo-inositol in which the two acyl groups contain a total of 36 carbon atoms and 4 double bonds.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl group at position 1 is unspecified while that at position 2 is specified as stearoyl (octadecanoyl).


2-acylglycerol 20:4

A 2-monoglyceride in which the acyl group contains 20 carbons and 4 double bonds.


phosphatidylinositol (16:0/18:2)

A phosphatidylinositol 34:2 in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 18 carbons and 2 double bonds


A 1-phosphatidyl-D-myo-inositol in which the acyl group at position 1 is specified as palmitoyl (hexadecanoyl) while that at position 2 is unspecified.


A glycerophosphoinositol acylated at O(1) of the glycerol moiety.


monoacylglycerol 18:1

A monoglyceride in which the acyl group contains a total of 18 carbon atoms and 1 double bond.


lysophosphatidylethanolamine 18:1

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 18 carbons and 1 double bond.


A phosphatidylinositol in which the inositol moiety is the 1D-myo isomer and the phosphatidyl group is located at its position 1.


triacylglycerol 60:14

A triglyceride in which the three acyl groups contain a total of 60 carbons and 14 double bonds.


lysophosphatidylethanolamine 22:5

A lysophosphatidylethanolamine in which the acyl group contains 22 carbons and 2 double bonds (position not specified).


A phosphatidylglycerol in which the phosphatidyl moiety has R-configuration and the glycerol moiety has S-configuration.


phosphatidylglycerol

A glycerophosphoglycerol that is glycerol in which the hydrogen of one of the primary hydroxy groups has been replaced by a phosphatidyl group.


phosphatidylethanolamine 40:5

A phosphatidylethanolamine in which the two acyl groups contain a total of 40 carbons and 5 double bonds.


phosphatidylethanolamine 40:7

A phosphatidylethanolamine in which the two acyl groups contain a total of 40 carbons and 7 double bonds.


phosphatidyl-L-serine

A class of aminophospholipids in which a phosphatidyl group is esterified to the hydroxy group of serine.


phosphatidylethanolamine 37:0

A phosphatidylethanolamine in which the two acyl groups contain a total of 37 carbons and no double bonds.


lysophosphatidylethanolamine 20:2

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 20 carbons and 2 double bonds.


A phosphatidylinositol 3-phosphate in which the inositol moiety is the D-myo-isomer.


A 1-phosphatidyl-1D-myo-inositol in which the 1- and 2-acyl groups are hexadecanoyl and icosatetraenoyl respectively.


phosphatidylethanolamine 35:2

A 1,2-diacyl-sn-glycero-3-phosphoethanolamine in which the two acyl groups contain a total of 35 carbons and 2 double bonds.


monoacylglycerol 16:1

A monoglyceride in which the acyl group contains a total of 16 carbon atoms and 1 double bond.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl group at position 1 is unspecified while that at position 2 is specified as linoleoyl


monooleoylglycerol

A monoglyceride in which the acyl group is oleoyl with the position of acylation unspecified.


Glyceryl monooleate

A 1-monoglyceride where the acyl group is oleoyl.


A 1-monoglyceride in which the glycerol moiety has sn stereochemistry.


triacylglycerol 50:6

A triglyceride in which the three acyl groups contain a total of 50 carbons and 6 double bonds.


1-acylglycerol 20:4

A 1-monoglyceride in which the acyl group contains 20 carbons and 4 double bonds.


Dioleoylphosphatidic acid

A phosphatidic acid in which the phosphatidyl acyl groups are both oleoyl.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl substituents at positions 1 and 2 are specified as gamma-linolenoyl and oleoyl respectively.


glycerophosphoglycerophosphoglycerol

A glycerophospholipid composed of two molecules of glycerol phosphate covalently linked to a molecule of glycerol, and in which each of the glycerol phosphate moieties may be esterified to one or two fatty acids.


2-acylglycerol 18:1

A 2-monoglyceride in which the acyl group contains 18 carbons and 1 double bond.


triacylglycerol O-51:2

An alkyldiacylglyceride that has a 51 carbons and 2 double bonds in the alkyl and acyl chains (positions not specified).


A 1-phosphatidyl-D-myo-inositol in which the acyl group at position 1 is specified as stearoyl (octadecanoyl) while that at position 2 is unspecified.


1-acylglycerol 18:0

A 1-monoglyceride in which the acyl group contains 18 carbons and is fully saturated.


lysophosphatidylethanolamine 20:0

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 20 carbons and is fully saturated.


A 1-monoglyceride with tetradecanoyl (myristoyl) as the acyl group.


A glycerol ether having an alkyl substituent at the oxygen at the 1-position and an acyl substituent at the oxygen at the 2-position.


phosphatidylinositol

Any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.


monoacylglycerol 14:0

A monoglyceride in which the acyl contains a total of 14 carbon atoms and 0 double bonds.


monoacylglycerol 18:0

A monoglyceride in which the acyl group contains a total of 18 carbon atoms and 0 double bonds.


triacylglycerol 54:6

A triglyceride in which the three acyl groups contain a total of 54 carbons and 6 double bonds.


A phosphatidic acid (36:2) in which both acyl groups are specified as octadec-9-enoyl.


A lysophosphatidylethanolamine obtained by selective hydrolysis of the 1-acyl substituent of any 1,2-diacyl-sn-glycero-3-phosphoethanolamine.


phosphatidylinositol 34:2

A 1-phosphatidyl-1D-myo-inositol in which the two acyl groups contain a total of 34 carbon atoms and 2 double bonds.


triacylglycerol 60:12

A triglyceride in which the three acyl groups contain a total of 60 carbons and 12 double bonds.


lysophosphatidylethanolamine 22:4

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 22 carbons and 4 double bonds.


lysophosphatidic acid

A member of the class of lysophosphatidic acids obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid. A 'closed' class.


phosphatidylglycerol phosphate

A phosphatidylglycerol in which one of the hydroxy groups of the glycerol moiety has been converted to the corresponding dihydrogen phosphate.


phosphatidylserine 38:3

A 3-sn-phosphatidyl-L-serine in which the two acyl groups contain a total of 38 carbon atoms and 3 double bonds.


A plasmalogen that has no fatty acyl chain at sn-2 and where the glycerolipid is not defined, R3 can be H or a phospholipid.


A 1-acylglycerophosphoinositol in which sn-glycerol, acylated at O(1), is linked through a phospho group at O(3) to O(1) of D-myo-inositol.


triacylglycerol 46:0

A triglyceride in which the three acyl groups contain a total of 46 carbons and 0 double bonds.


phosphoinositide

Any phosphatidylinositol that is phosphorylated at one or more of the hydroxy groups of inositol.


1,3-Dihydroxypropan-2-yl formate

A glyceride in which any one of the R groups (position not specified) is an acyl group while the remaining two R groups can be either H or alkyl groups.


A 1-monoglyceride that has octadecadienoyl (linoleoyl) as the acyl group.


Glyceryl arachidonate

A 1-monoglyceride where the acyl group is arachidonoyl.


triacylglycerol 45:0

A triglyceride in which the three acyl groups contain a total of 45 carbons and 0 double bonds.


A triglyceride in which the acyl groups at positions 1 and 2 are specified as oleoyl while that at position 3 is specified as palmitoyl.


phosphatidylinositol 38:4

A 1-phosphatidyl-1D-myo-inositol in which the two acyl groups contain a total of 38 carbon atoms and 4 double bonds.


1,2-diacyl-sn-glycerol 3-phosphate

An sn-glycerol 3-phosphate compound having unspecified O-acyl groups at the 1- and 2-positions.


triacylglycerol 54:8

A triglyceride in which the three acyl groups contain a total of 54 carbons and 8 double bonds.


lysophosphatidylethanolamine

A glycerophosphoethanolamine resulting from partial hydrolysis of a phosphatidylethanolamine, which removes one of the fatty acid groups. The structure is depicted in the image where R(1) = acyl, R(2) = H or where R(1) = H, R(2) = acyl.


A lysophosphatidylethanolamine 18:1 in which the acyl group is located at position 1.


glycerophospholipid

Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.


lysophosphatidic acids

Any monoacylglycerol phosphate obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid or derivatives therein.


Triglyceride

Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


triacyl-sn-glycerol

Any optically active triglyceride that has R-configuration.


2-acylglycerol 16:1

A 2-monoglyceride in which the acyl group contains 16 carbons and 1 double bond.


2-acylglycerol 18:2

A 2-monoglyceride in which the acyl group contains 18 carbons and 2 double bonds.


lysophosphatidylethanolamine 20:4

An acyl-sn-glycero-3-phosphoethanolamine in which the acyl group contains twenty carbons and four double bonds. If R1 is an acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphoethanolamine. If R1 is a hydrogen and R2 is an acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphoethanolamine.


A monoglyceride in which the acyl substituent is located at position 2.


A chiral alkylglycerol having the alkyl group at the 1-position.


Diphosphatidylglycerol

A phosphatidylglycerol composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol.


triacylglycerol 62:15

A triglyceride in which the three acyl groups contain a total of 62 carbons and 15 double bonds.


An alkylglycerol having the alkyl group located at either the sn-1 or sn-3 position.


2-acylglycerol 16:0

A 2-monoglyceride in which the acyl group contains 16 carbons and is fully saturated.


1-acylglycerol 16:0

A 1-monoglyceride in which the acyl group contains 16 carbons and is fully saturated.


phosphatidic acid 36:2

A phosphatidic acid in which the two acyl groups contain a total of 36 carbons and 2 double bonds.


2-lysophosphatidic acid

Any member of the class of lysophosphatidic acids which has a free hydroxy group at the 2-position of the glycerol moiety.


A glycerophosphoethanolamine having an unspecified O-acyl substituent at the 1-position of the glycerol fragment.


phosphatidylethanolamine 42:5

A phosphatidylethanolamine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 5 double bonds.


1-acylglycerol 18:1

A 1-monoglyceride in which the acyl group contains 18 carbons and 1 double bond.


A 1-acyl-sn-glycerol 3-phosphate having palmitoyl as the acyl group.


A 1-O-acylglycerophosphoethanolamine having (R)-configuration.


A 3-sn-phosphatidyl-L-serine in which the 1- and 2-acyl groups are octadecanoyl and icosatrienoyl respectively.


diradylglycerol

Any lipid that is glycerol bearing two substituent groups - either acyl, alkyl, or alk-1-enyl - at any two of the three possible positions.


phosphatidylserine 36:2

A 3-sn-phosphatidyl-L-serine in which the two acyl groups contain a total of 36 carbon atoms and 2 double bonds.


monoacyl-sn-glycerol 3-phosphate

An sn-glycero-3-phosphate compound having a single unspecified acyl group at either position 1 or position 2.


phosphatidylserine (18:0/22:5)

A phosphatidylserine 40:5 in which the acyl group at C-1 contains 18 carbons and no double bonds while that at C-2 contains 22 carbons and 5 double bonds.


phosphatidic acid

A derivative of glycerol in which one hydroxy group, commonly but not necessarily primary, is esterified with phosphoric acid and the other two are esterified with fatty acids.


A 1-alkyl-2-acylglycerol having acetyl as the acyl substituent.


lysophosphatidylethanolamine 20:5

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 20 carbons and 5 double bonds.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl group at position 1 is unspecified while that at position 2 is specified as oleoyl


phosphatidylinositol 3-phosphate

A phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.


A 1-monoglyceride that has alpha-linolenoyl as the acyl group.


That one of the three tautomers of pyrrole which has the double bonds at positions 1 and 4.


(S)-idazoxan

An idazoxan that has S configuration.


Abiraterone

A 3beta-sterol that is androsta-5,16-dien-3beta-ol substituted at position 17 by a 3-pyridyl group. Administered as the O-acetate, it is used for treatment of metastatic castrate-resistant prostate cancer.


BCLC Stage 0 Adult Hepatocellular Carcinoma

Very early hepatocellular carcinoma. Patients are optimal candidates for resection. (HPB (Oxford) 2005; 7(1):35-41)


Trichloroiron;hexahydrate

A hydrate that is the hexahydrate form of iron trichloride.


Prednisolone hemisuccinate

A hemisuccinate resulting from the formal condensation of the 21-hydroxy group prednisolone with one of the carboxy groups of succinic acid. It is used to treat mild to moderate non-infectious eye allergies and inflammation, including damage caused by chemical and thermal burns.


Bethanechol chloride

The chloride salt of bethanechol. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.


The (S)-enantiomer of bethanechol chloride.


Vitamin D4

It is present in mushrooms.


1alpha,25-dihydroxy-22-oxavitamin D3 3-hemiglutarate/1alpha,25-dihydroxy-22-oxacholecalciferol 3-hemiglutarate


previtamin D3

A hydroxy seco-steroid which is an intermediate in the production of vitamin D3 in human skin.


23(S),25-dihydroxy-24-oxovitamin D3

A hydroxycalciol that is 25-hydroxyvitamin D3 carrying an additional hydroxy group at position 23 (with 23S-configuration) and an oxo group at position 24. An intermediate in the degradation pathway of 25-OH-vitamin D3.


(20S,24S)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 and 24 (both with S-configuration).


(5Z)-1alpha,25-dihydroxy-3-deoxy-3-thiavitamin D3 3-oxide/(5Z)-1alpha,25-dihydroxy-3-deoxy-3-thiacholecalciferol 3-oxide


calcidiol 3-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 3 has been replaced by a beta-D-glucuronyl residue.


1,24(S)-Dihydroxyvitamin D2

Metabolite of vitamin D2. It  present in the circulation of humans, cows, and rats given pharmacologic doses of vitamin D2


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity.


(20S)-hydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying an additional hydroxy group at position 20 with S-configuration.


A hydroxycalciol that is calciol with an additional hydroxy group at position C-1 and an acetoxy group at C-18.


(20S,23)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 23.


1alpha-hydroxy-25,26,27-trinorvitamin D3 24-carboxylic acid


(23S,25R)-25-hydroxyvitamin D3 26,23-lactol/(23S,25R)-25-hydroxycholecalciferol 26,23-lactol


Vitamin D5

A vitamin D in which the side-chain at position 17 consists of a (5R)-5-ethyl-6-methylheptan-2-yl group.


1alpha,25-Dihydroxyvitamin D3 25-trimethylsilyl ether


1alpha,2beta,25-trihydroxy vitamin D3

A hydroxy seco-steroid that is calciol carrying three additional hydroxy substituents at positions 1alpha, 2beta and 25.


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity


D3 vitamins

A vitamin D that is calciol or its hydroxylated metabolites calcidiol and calcitriol. Calciol (also known as vitamin D3) acts as a hormone precursor, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.


A hydroxycalciol that is calcitriol with an acetoxy group at C-18.


25-Hydroxyvitamin D2

A hydroxycalciol that is vitamin D2 in which the hydrogen at position 25 has been replaced by a hydroxy group.


5,6-trans-Vitamin D3

A member of the class of D3 vitamins that is calciol in which the double bond at position 5 adopts a trans-configuration. During exposure to sunlight, previtamin D3 and vitamin D3 in the skin become photoisomerized to 5,6-trans-vitamin D3.


Tacalcitol

A hydroxy seco-steroid that is calciol which carries hydroxy groups at positions 1S and 24R. It is a vitamin D3 analog which is used for the treatment of psoriasis vulgaris in adults, especially on the scalp.


(20S,24R)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration) and 24 (with R-configuration).


20(S),25-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 25.


Doxercalciferol

A hydroxy seco-steroid and synthetic vitamin D2 analogue that undergoes metabolic activation in vivo to form 1alpha,25-dihydroxyvitamin D2 (1alpha,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. It is used to treat secondary hyperparathyroidism, a condition in which the body produces excess parathyroid hormone (PTH; a natural substance needed to control the amount of calcium in the blood) in certain people with chronic kidney disease.


A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 25 has been replaced by a beta-D-glucuronyl residue.


Extramedullary Disease in Plasma Cell Myeloma Involving the Spleen

Infiltration of the spleen by malignant (clonal) plasma cells in patients with history of plasma cell myeloma


Latrunculin a

A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.


Thiacloprid-amide

A monochloropyridine that is 2-chloropyridine substituted by a [2-(carbamoylimino)-1,3-thiazolidin-3-yl]methyl group at position 5. It is a metabolite of the insecticide thiacloprid.


A member of the class of thiazolidinones that is 3-[(dimethylamino)methyl]-1,3-thiazolidine-2,4-dione bearing an additional (4-methoxyphenyl)methylidene substituent at position 5.


3-[4-Oxo-5-(phenylmethylene)-2-sulfanylidene-3-thiazolidinyl]propanoic acid butyl ester


A thiazolidinone that is 1,2-thiazolidin-3-one bearing an amino substituent at position 4.


A member of the class of thiazolidinone that is rhodanine in which the two methylene hydrogens have been replaced by a 2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl]methylidene group. A TRPA1 ligand that can be reversibly photoactivated.


Pyochelin

A member of the class of thiazolidines that is (4R)-3-methyl-1,3-thiazolidine-4-carboxylic acid which is substituted at position 2 by a (4R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazol-4-yl group. A siderophore that is produced by Pseudomonas aeruginosa (via condensation of salicylic acid and two molecules of cysteine) as a mixture of two easily interconvertible diastereoisomers, pyochelin I (major) and pyochelin II (minor). The enantiomeric compounds, enant-pyochelin, are produced by Pseudomonas fluorescens.


A thiazolidinone that is 2-thioxo-4-thiazolidinone which is substituted at position 3 by a (m--trifluoromethyl)phenyl group and at position 5 by a p-carboxybenzylidene group. It is an inhibitor of cystic fibrosis transmembrane conductance regulator, a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene.


A member of the class of oxindoles that is 5-chloro-oxindole in which the methylene hydrogens at position 3 have been replaced by an N-(2-carboxyethyl)rhodanin-5-ylidene group.


Yersiniabactin

A member of the class of thiazolidines that is (4S)-4-methyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid which is substituted at position 2 by a (1S)-1-hydroxy-1-{(4R)-2-[(4R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazol-4-yl]-1,3-thiazolidin-4-yl}-2-methylpropan-2-yl group. A siderophore found in the gram-negative bacterium species, Yersinia enterocolitica and Yersinia pestis.


Flutianil

A member of the class of thiazolidines that is N-(o-methoxyphenyl)thiazolidine which is substituted at position 2 by a methylene group, the hydrogens of which are replaced by cyano and [2-fluoro-5-(trifluoromethyl)phenyl]sulfanediyl groups; the double bond conjugated to the cyano group has Z configuration. A fungicide intended for use on horticultural crops including strawberries and grapevines.


A member of the class of thiazolidinones that is 2-sulfanylidene-1,3-thiazolidin-4-one in which the hydrogens at positions 3 and 5 are replaced by carboxymethyl and 3-(1-phenylethoxy)-4-(2-phenylethoxy)benzylidene groups, respectively. It is an inhibitor of protein mannosyl transferase 1 (PMT1) and blocks protein O-mannosylation.


PI3K inhibitor GS1059615

A thiazolidinone that is the 5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene} derivative of 1,3-thiazolidine-2,4-dione. A PI3K inhibitor


A thiazolidenedione carrying oxo substituents at positions 2 and 4.


Pyochelin II

A pyochelin that has S-stereochemistry at the thioaminal centre; the diastereoisomer with R-stereochemistry at this centre is pyochelin I. Pseudomonas aeruginosa produces a mixture of pyochelin I (major) and pyochelin I (minor) via condensation of salicylic acid and two molecules of cysteine. The enantiomeric compounds, enant-pyochelin I and II, are produced by Pseudomonas fluorescens.


Ciglitazone

An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.


1,3-Thiazolidine substituted with methyl groups at C-2, -5 and -5 and with a carboxy group at C-4, representing the thiazolidine ring of a generalised penicillin structure.


Hydroxypioglitazone

A member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone.


A trimethyl-substituted thiazolidine carboxylic acid derived by cleavage of and loss of C=O from the azetidine ring of penicillanic acid.


A  thiazolidinecarboxamide that is 1,3-thiazolidine-2-carboxamide substituted by a methyl group at position 2.


A pyochelin that has R-stereochemistry at the thioaminal centre; the diastereoisomer with S-stereochemistry at this centre is pyochelin II. Pseudomonas aeruginosa produces a mixture of pyochelin I (major) and pyochelin II (minor) via condensation of salicylic acid and two molecules of cysteine. The enantiomeric compounds, enant-pyochelin I and II, are produced by Pseudomonas fluorescens.


latrunculin B

A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.


Lugdunin

A thiazolidine-containing homodetic cyclic peptide that is isolated from human nasal bacteria. Exhibits bactericidal activity against many major pathogens including methicillin-resistant Staphylococcus aureus (MRSA).


THIACLOPRID

The (Z)-stereoisomer of thiacloprid.


thiazolidinediones

A thiadiazolidine in which the 1,3-thiazolidine ring is substituted by two oxo groups.


Benzylpenicilloic acid

A penicilloic acid where the side-chain N-acyl group is specified as phenylacetyl.


Benzylpenicilloyl cysteine

A compound obtained from nucleophilic cleavage of the beta-lactam ring of benzylpenicillin by the amino group of L-cysteine.


A thiazolidinone that is 2-sulfanylidene-1,3-thiazolidin-4-one substituted by 3-{[3-(morpholin-4-yl)propyl]amino}-3-oxopropyl and 4-ethylbenzylidene groups at positions 3 and 5, respectively. It is a ferroptosis inducer.


rhodanine 3-acetic acid derivative

Any thiazolidinone that is derived from rhodanine 3-acetic acid.


A member of the class of thiazolidinones that is 2-sulfanylidene-1,3-thiazolidin-4-one which is substituted at position 5 by a (4-ethylphenyl)methylidene group. It is a cell permeable inhibitor of c-Myc-Max dimerization and exhibits antitumour effects in vivo. It downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27 resulting in the inhibition of proliferation, induction of apoptosis and cell cycle arrest in G0/G1 phase.


Thiacloprid

A  nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen.


penicilloic acid

A thiazolidinedicarboxylic acid obtained via hydrolysis of the beta-lactam ring of a penicillin.


A member of the class of thiazolidinones that is 1,1-dioxo-2,3-diphenyl-1,3-thiazolidin-4-one bearing an additional (4-methoxyphenyl)methylidene substituent at position 5.


Epalrestat

A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.


Pentamethonium bromide

The bromide salt of pentamethonium. It is a ganglion blocker and exhibits antihypertensive activity.


dichlorobenzene

Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.


A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of econazole.


Fenpiclonil

A member of the class of pyrroles carrying cyano and 2,3-dichlorophenyl substituents at positions 3 and 4 respectively. A fungicide used mainly to control seed-borne pathogens in cereal crops.


(S)-Tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of tioconazole.


A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of econazole.


Tienilic acid

An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links with hepatitis.


clonidine (amino form)

A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.


(S)-Miconazole

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has S) configuration.


A member of the class of indolones that is 1,3-dihydro-2H-indol-2-one which is substituted by a (2,6-dichlorobenzyl)sulfonyl group at position 5 and by a (1H-pyrrol-2-yl)methylidene group at position 2, the pyrrole ring of which is substituted by methyl groups at positions 3 and 5, and by a [2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl group at position 4 (the Z,R isomer).


Arasertaconazole

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the active R-enantiomer of sertaconazole and is used (as its nitrate salt) for treatment of vulvovaginal candidiasis. The racemate itself is also used as a broad-spectrum antifungal drug.


(R)-Miconazole

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has R configuration.


(R)-Tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of tioconazole.


(S)-Sertaconazole

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of sertaconazole.


A steroid glucosiduronic acid that is 2-hydroxyestrone having a single beta-D-glucuronic acid residue attached at position 3.


Stage IV Rectosigmoid Cancer AJCC v7

Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Any 3beta-hydroxy steroid which is substituted at the 4alpha and 4beta positions by hydroxymethyl and methyl groups, respectively.


A 4alpha-hydroxymethyl steroid that is 5-alpha-cholest-7-en-3beta-ol in which the alpha-hydrogen at position 4 has been replaced by a hydroxymethyl group.


Any 3beta-hydroxy steroid which is substituted at the 4alpha and 4beta positions by methyl and hydroxymethyl groups, respectively.


A 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid that is 14-demethyllanosterol in which the methyl group at the 4beta position has been oxidised to the corresponding hydroxymethyl group.


Stage IIA2 Cervical Cancer FIGO 2018

Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, equal or more than 4 cm in greatest dimension. (FIGO 2018)


Triazine

Compounds based on a triazine skeleton.


Any compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure.


Any compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure.


Thifensulfuron-methyl

A methyl ester resulting from the formal condensation of the carboxy group of thifensulfuron with methanol. It is used  as a post-emergence herbicide for the control of grass and broad-leaved weeds.


Quinazoline

A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.


Thifensulfuron

An N-sulfonylurea in which the sulfur atom is attached to a 2-carboxythiophen-3-yl group and in which the non-sulfonated nitrogen is substituted by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. The corresponding methyl ester, known as thifensulfuron-methyl, is used as a post-emergence herbicide for the control of grass and broad-leaved weeds.


3-hydroxy fatty acyl-CoA

A hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any 3-hydroxy fatty acid.


methylbutanoyl-CoA

Any member of the class of  butanoyl-CoAs having methylbutanoyl as the acyl substituent.


glutaconyl-CoA

A  2-enoyl-CoA that is the glutaconyl derivative of CoA.


octadecenoyl-CoA

Any unsaturated fatty acyl-CoA in which the S-acyl moiety contains 18 carbons and 1 double bond.


guanyl ribonucleotide

A purine ribonucleotide where the purine is guanine.


Generic name for any derivative of coenzyme A in which the thiol group is in thioester linkage with an acyl group containing a C=C double bond beta to the thioester linkage.


octadecatrienoyl-CoA

An unsaturated fatty acyl-CoA in which the S-acyl moiety contains 18 carbons and 3 double bonds at unknown positions.


fatty acyl-CoA

An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any fatty acid.


short-chain fatty acyl-CoA

A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any short-chain fatty acid.


purine ribonucleotide

Any ribonucleotide that has a purine nucleobase.


An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any alpha,beta-unsaturated fatty acid.


branched-chain fatty acyl-CoA

A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any branched-chain fatty acid.


3-Hydroxybutyryl-coenzyme A

A hydroxybutanoyl-CoA having 3-hydroxybutanoyl as the S-acyl component.


acyl-CoA

A thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid.


malonyl-CoAs

Any short-chain fatty acyl-CoA in which the the fatty acid specified is malonic acid or its derivatives.


An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any 3-hydroxy carboxylic acid.


omega-carboxyacyl-CoA

An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of any alpha,omega-dicarboxylic acid.


3-oxo-fatty acyl-CoA

An oxo fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any 3-oxo-fatty acid..


adenyl ribonucleotide

A purine riboncleotide where adenine is the purine.


benzoyl-CoAs

Any  aroyl-CoA in which the  aroyl group is specified as benzoyl or its substituted derivative.


medium-chain fatty acyl-CoA

A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any medium-chain fatty acid.


hydroxyacyl-CoA

An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any hydroxycarboxylic acid.


A 3-enoyl-CoA in which the beta C=C double bond has trans stereochemistry.


ribonucleoside 3'-monophosphate

A ribonucleoside monophosphate in which the phosphate group is at the ribosyl 3-position.


hydroxy fatty acyl-CoA

A fatty-acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any hydroxy fatty acid.


steroidal acyl-CoA

An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any steroidal carboxylic acid.


3-substituted propionyl-CoA

An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any 3-substituted propionic acid (R =/= H).


(R)-lipoyl-AMP

A lipoyl-AMP in which the lipoyl moiety has (R)-configuration.


octadecadienoyl-CoA

An unsaturated fatty acyl-CoA in which the S-acyl moiety contains 18 carbons and 2 double bonds at unknown positions.


methyl-branched fatty acyl-CoA

A branched-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any methyl-branched fatty acid.


An unsaturated fatty acyl-CoA in which the S-acyl group contains a double bond between positions 2 and 3.


long-chain fatty acyl-CoA

A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any long-chain (C13 to C22) fatty acid.


butanoyl-CoAs

Any short-chain fatty acyl-CoA in which the acyl group specified is butanoyl or its substituted derivative.


A short-chain, methyl-branched fatty acyl-CoA having 2-methylbutanoyl as the S-acyl group.


11,12-saturated fatty acyl-CoA

Any fatty acyl-CoA in which the 11-12 bond of the fatty acyl group is saturated.


An alpha,omega dicarboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of 3-hydroxy-3-methylglutaric acid.


aroyl-CoA

A acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any aromatic carboxylic acid.


monounsaturated fatty acyl-CoA

Any unsaturated fatty acyl-CoA in which the fatty acyl chain contains one carbon-carbon double bond.


unsaturated fatty acyl-CoA

A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any unsaturated fatty acid.


glutaryl-CoAs

Any  omega-carboxyacyl-CoA in which the acyl group specified is glutaryl or its substituted derivative.


multi-methyl-branched fatty acyl-CoA

A branched-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any multi-methyl-branched fatty acid.


oxo-fatty acyl-CoA

A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any oxo-fatty acid.


Pristanoyl-CoA in which C-2 of the pristanoyl group has R-configuration.


very long-chain fatty acyl-CoA

A fatty acyl-CoA in which the fatty acyl group has a chain length greater than C22.


A cholestanoyl-CoA formed by thioester linkage between 3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid and coenzyme A.


cholestanoyl-CoA

A steroidal acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any cholestan-26-oic acid.


hydroxybutanoyl-CoA

Any member of the class of  butanoyl-CoAs having hydroxybutanoyl as the acyl substituent.


Pristanoyl-CoA in which C-2 of the pristanoyl group has S-configuration.


A methyl-branched fatty acyl-CoA in which the unspecified acyl group carries a methyl substituent at position 2.


Stage III Rectal Cancer AJCC v7

Stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Advanced Colorectal Carcinoma

Colorectal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Hereditary Colon Carcinoma

Colon carcinoma that has developed in relatives of patients with a history of colon carcinoma.


Stage II Colorectal Cancer AJCC v8

Stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colon Serrated Adenocarcinoma

A rare, invasive colon adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture.


Adenoma of the Colon with Intramucosal Adenocarcinoma

An intramucosal malignant glandular epithelial infiltrate in a colonic adenoma.  There is no evidence of submucosal invasion.


Colorectal Adenocarcinoma Metastatic in the Liver

An adenocarcinoma that originates from the colorectal area and has spread to the liver.


Unresectable Colon Adenocarcinoma

A colon adenocarcinoma that is not amenable to surgical resection.


Stage IIC Colon Cancer AJCC v7

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Colon Cancer by AJCC v8 Stage

A term that refers to the staging of colon cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to adenocarcinomas, high-grade neuroendocrine carcinomas, and squamous cell carcinomas of the colon. (from AJCC 8th Ed.)


Stage IVB Colon Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis.  (AJCC 8th ed.)


Stage I Colorectal Cancer AJCC v6 and v7

Stage I includes: (T1, N0, M0); (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Metastatic Colon Carcinoma

A carcinoma that arises from the colon and has metastasized to another anatomic site.


Childhood Rectal Carcinoma

A rare carcinoma of the rectum that occurs during childhood.


Stage IIIA Colorectal Cancer AJCC v7

Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2a: Metastasis in 4-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIB Colorectal Cancer AJCC v8

Stage IIB includes: T4a, N0, M0. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Colorectal Adenocarcinoma

A colorectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with 50-95% glandular formation.


Stage IVB Colorectal Cancer AJCC v7

Stage IVB includes: Any T, Any N, M1b.  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Rectosigmoid cancer recurrent

The reemergence of rectosigmoid carcinoma after a period of remission.


Stage IIIC Rectal Cancer AJCC v7

Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes. N2: Metastasis in four or more regional lymph nodes. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Rectosigmoid Cancer AJCC v6

Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


Rectosigmoid Cancer by AJCC v7 Stage

A term that refers to the staging of rectosigmoid carcinoma according to the American Joint Committee on Cancer, 7th edition.


Metastatic Malignant Colorectal Neoplasm

A malignant neoplasm that arises in the colon or rectum that has spread from its original site of growth to other anatomic sites.


Metastatic Rectal Carcinoma

A carcinoma that arises from the rectum and has metastasized to another anatomic site.


Stage IVC Colon Cancer AJCC v8

Stage IVC includes: Any T, Any N, M1c. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Rectal Cancer by AJCC v6 Stage

A term that refers to the staging of rectal carcinoma according to the American Joint Committee on Cancer, 6th edition.


Stage IIIA Rectal Cancer AJCC v8

Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Rectal Carcinoma Metastatic in the Liver

A carcinoma that originates from the rectum and has spread to the liver.


Refractory Colon Carcinoma

Colon carcinoma that is resistant to treatment.


Stage IVB Colorectal Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis.  (AJCC 8th ed.)


Colorectal Cancer by AJCC v6 Stage

A term that refers to the staging of colorectal carcinoma according to the American Joint Committee on Cancer, 6th edition.


Unresectable Colon Carcinoma

Colon carcinoma that is not amenable to surgical resection.


Childhood Colorectal Carcinoma

A rare colorectal carcinoma that occurs during childhood.


Grade 1 Colorectal Adenocarcinoma

A colorectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with more than 95% glandular formation.


Stage II Colon Cancer AJCC v7

Stage II includes: IIA (T3, N0, M0); IIB (T4a, N0, M0); IIC (T4b, N0, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IVA Rectal Cancer AJCC v8

Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis to one site or organ without peritoneal metastasis. (AJCC 8th ed.)


Microsatellite Stable Colorectal Carcinoma

Colorectal carcinoma characterized by the absence of microsatellite instability.


Refractory Colorectal Carcinoma

Colorectal carcinoma that does not respond to treatment.


Colon Intramucosal Adenocarcinoma

An adenocarcinoma that arises from the colonic glandular epithelium and invades the lamina propria or muscularis mucosa but not the submucosa.


Colorectal Cribriform Comedo-Type Adenocarcinoma

A rare, invasive colorectal adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.


Refractory Colon Adenocarcinoma

Colon adenocarcinoma that is resistant to treatment.


Stage IIC Colon Cancer AJCC v8

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Colorectal Cancer AJCC v7

Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Stage II Rectal Cancer AJCC v8

Stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Unresectable Rectal Adenocarcinoma

A rectal adenocarcinoma that is not amenable to surgical resection.


Colorectal Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon or rectum. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Rectosigmoid Mucinous Adenocarcinoma

An invasive adenocarcinoma of the rectosigmoid area characterized by the presence of pools of extracellular mucin.  Malignant glandular epithelial cells are present in the mucin collections.  Mucin constitutes more than 50% of the lesion.


Stage 0 Rectosigmoid Cancer AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial or invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Stage IVC Rectal Cancer AJCC v8

Stage IVC includes: Any T, Any N, M1c. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Rectal Cancer by AJCC v7 Stage

A term that refers to the staging of rectal carcinoma according to the American Joint Committee on Cancer, 7th edition.


Stage IVA Colorectal Cancer AJCC v7

Stage IVA includes: Any T, Any N, M1a.  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  (AJCC 7th ed.)


Stage IVB Colon Cancer AJCC v7

Stage IVB includes: Any T, Any N, M1b. M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Grade 2 Colon Adenocarcinoma

A colon adenocarcinoma characterized by the presence of a malignant cellular infiltrate with 50-95% glandular formation.


Stage III Colorectal Cancer AJCC v6

Stage Group III is subdivided into IIIA (T1-2, N1, M0), IIIB (T3-4, N1, M0) or IIIC (any T, N2 M0).  T1: Tumor invades the submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into the subserosa or into non-peritonealized pericolic or perirectal tissues.  T4: Tumor directly invades other organs or structures, and/or perforates visceral peritoneum.  N1: Metastasis in 1 to 3 regional lymph nodes N2: Metastasis in 4 or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 6th ed.)