prion disease

A transmissible disease that is caused by a protein that is able to induce abnormal folding of normal cellular proteins, leading to characteristic spongiform brain changes, which are associated with neuronal loss without an inflammatory response. Such disorders have typically long incubation periods, but are then generally rapidly progressive and are uniformly fatal.


familial severe combined immunodeficiency

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anomaly of puberty or/and menstrual cycle


endocrine gland neoplasm

A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. Representative examples include pituitary gland adenoma, pituitary gland carcinoma, thyroid gland carcinoma, carcinoid tumor, and neuroendocrine carcinoma.


obesity due to leptin receptor gene deficiency

Deficiency or dysfunction of the leptin receptor associated with loss-of-function mutation(s) in the LEPR gene.


Prader-Willi-like syndrome

Prader-Willi-like syndrome is a rare, genetic, endocrine disease characterized by manifestations of a Prader-Willi syndrome phenotype (including obesity, hyperphagia, hypotonia, psychomotor delay, intellectual disability, small hands/feet, hypogonadism, growth hormone deficiency and characteristic facial features) ocurring in the absence of 15q11-q13 genomic abnormalities.


premenopausal osteoporosis

Osteoporosis occuring in premenopausal women with existing fragility fractures, diseases or treatments known to cause bone loss or fractures.


glycerol kinase deficiency, juvenile form

Juvenile glycerol kinase deficiency (GKD) is an uncommon form of GKD characterized by Reye-like clinical manifestations including episodic vomiting, acidemia, and disorders of consciousness.


iron metabolism disease

Disorders in the processing of iron in the body: its absorption, transport, storage, and utilization.


dopa-responsive dystonia

Dopa-responsive dystonia (DRD) describes a group of neurometabolic disorders characterized by dystonia that typically shows diurnal fluctuations, that responds excellently to levodopa (L-dopa) and that is comprised of autosomal dominant dopa-responsive dystonia (DYT5a), autosomal recessive dopa-responsive dystonia (DYT5b) and dopa responsive dystonia due to sepiapterin reductase (SR) deficiency.


osteogenesis imperfecta

Osteogenesis imperfecta (OI) comprises a heterogeneous group of genetic disorders characterized by increased bone fragility, low bone mass, and susceptibility to bone fractures with variable severity.


developmental disorder of mental health

A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development.


inborn serine deficiency

An inherited metabolic disease that is has its basis in the disruption of L-serine biosynthetic process.


uterine cervix neoplasm

A neoplasm (disease) that involves the uterine cervix.


hereditary skeletal muscle disorder

An instance of muscle tissue disorder that is caused by an inherited genomic modification in an individual.


disorder of thiamine metabolism and transport


hereditary hyperbilirubinemia

An inherited disorder affecting the metabolism of bilirubin. It results in increased levels of bilirubin in the blood. Representative examples of this condition include Gilbert syndrome and Crigler-Najjar syndrome.


immune system cancer

A malignant neoplasm involving the immune system


malignant mixed epithelial and mesenchymal tumor of cervix uteri


renal tubular transport disease

Genetic defects in the selective or non-selective transport functions of the kidney tubules.


familial hypoaldosteronism

Aldosterone synthase deficiency is a rare inherited defect of the final step of aldosterone biosynthesis (conversion of deoxycorticosterone to aldosterone).


otorhinolaryngologic disease

Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.


mitochondrial DNA depletion syndrome

The mitochondrial DNA (mtDNA) depletion syndrome (MDS) is a clinically heterogeneous group of mitochondrial disorders characterized by a reduction of the mtDNA copy number in affected tissues without mutations or rearrangements in the mtDNA. MDS is phenotypically heterogeneous, and can affect a specific organ or a combination of organs, with the main presentations described being either hepatocerebral (i.e. hepatic dysfunction, psychomotor delay), myopathic (i.e. hypotonia, muscle weakness, bulbar weakness), encephalomyopathic (i.e. hypotonia, muscle weakness, psychomotor delay) or neurogastrointestinal (i.e gastrointestinal dysmotility, peripheral neuropathy). Additional phenotypes include fatal infantile lactic acidosis with methylmalonic aciduria, spastic ataxia (early-onset spastic ataxia-neuropathy syndrome), and Alpers syndrome.


glycoprotein metabolism disease

A disease that has its basis in the disruption of glycoprotein metabolic process.


Pelizaeus-Merzbacher disease, classic form

The classic form of Pelizaeus-Merzbacher disease (PMD) is the infantile form of PMD.


disorder of organic acid metabolism

A disease that has its basis in the disruption of organic acid metabolic process.


coenzyme Q10 deficiency, primary, 3

Any coenzyme Q10 deficiency in which the cause of the disease is a mutation in the PDSS2 gene.


metabolic epilepsy

Metabolic epilepsies are conceptualized as having a distinct metabolic abnormality that has been demonstrated to be associated with a substantially increased risk of developing epilepsy in appropriately designed studies. Metabolic disorders have genetic origin; however, the metabolic abnormalities are a separate disorder interposed between the genetic defect and the epilepsy.


infantile glycine encephalopathy

Infantile glycine encephalopathy is a mild to severe form of glycine encephalopathy (GE), characterized by early hypotonia, developmental delay and seizures.


atactic disorder

A central nervous system disease that consists of gait impairment, unclear (“scanning”) speech, visual blurring due to nystagmus, hand incoordination, and tremor with movement.


A 1-phosphatidyl-1D-myo-inositol in which the 1- and 2-acyl groups are octadecanoyl and icosatetraenoyl respectively.


N-acylammonia

A carboxamide obtained by the formal condensation of the carboxy group of any carboxylic acid with ammonia.


A pyrazinecarboxamide in which a 6-oxo-1,6-dihydropyrazine nucleus is substituted on C-5 by a 4-hydroxyphenyl group and on C-2 by a butylcarbamyl group. A synthetic determinant of cefadroxil, it is a promising tool for determining in vitro cross-reactivity to cefadroxil in amoxicillin-allergic patients.


Foradil

An N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide in which both of the stereocentres have S configuration.


An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2.


Stage IIIB Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIIB Colon Cancer AJCC v8

Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage III Colon Cancer AJCC v8

Stage III includes: IIIA: (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIC Colon Cancer AJCC v8

Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIA Colon Cancer AJCC v8

Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


uronic acid

A carbohydrate acid formally derived by oxidation to a carboxy group of the terminal -CH2OH group of any aldose or ketose.


D-galacturonic acid

The D-enantiomer of galacturonic acid. It is the main component of pectin.


D-Galacturonic Acid

The pyranose form of D-galacturonic acid


D-Glucuronic Acid

A D-glucuronic acid in cyclic pyranose form.


D-glucuronic acid

The D-enantiomer of glucuronic acid.


An N-substituted pyrraline formed via Maillard reaction of L-ornithine with glucose.


Fulvestrant

A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.


diester

A diester is a compound containing two ester groups.


doxacurium chloride

The dichloride salt of doxacurium. It is a mixture of the (1R,2S,1'S,2'R), (1R,2S,1'R,2'S) and (1S,2R,1'S,2'R) stereoisomers (a meso isomer and two enantiomers, respectively) of 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxypropane-3,1-diyl)]bis[6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium] dichloride, all of which are in a trans configuration at the 1 and 2 positions of the tetrahydroisoquinolinium rings. A competitive neuromuscular blocker, it is used to provide muscle relaxation in general anaesthesia and to facilitate mechanical ventilation in patients in intensive care.


(r)-Malathion

A diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate that is the R-enantiomer of malathion.


Doxacurii chloridum

The dichloride salt of meso-doxacurium.


(S)-Nisoldipine

A methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate that has S configuration.


(S)-Nicardipine

The S-enantiomer of nicardipine.


(S)-Malathion

A diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate that is the S-enantiomer of malathion.


(+/-)-Doxacurium chloride

The dichloride salt of (1R,2S,1'R,2'S)-doxacurium.


(R)-Nisoldipine

A methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate that has R configuration.


(1S,2R,1'S,2'R)-doxacurium chloride

The dichloride salt of (1S,2R,1'S,2'R)-doxacurium.


(R)-Nicardipine

The R-enantiomer of nicardipine.


Danshensu

A (2R)-2-hydroxy monocarboxylic acid that is (R)-lactic acid substituted at position 3 by a 3,4-dihydroxyphenyl group.


delta-Tocotrienol

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2 and 8 and a farnesyl chain at position 2.


chromanol

Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups.


The (S,R,S)-stereoisomer of alpha-tocopherol.


beta-Tocotrienol

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5 and 8 and a farnesyl chain at position 2. It has been isolated from various cultivars of wheat.


The (R,R,S)-stereoisomer of alpha-tocopherol.


alpha-tocopherol

A tocopherol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a 4,8,12-trimethyltridecyl group at position 2.


(S,S,R)-alpha-Tocopherol

The (S,S,R)-stereoisomer of alpha-tocopherol.


(R,S,R)-alpha-Tocopherol

The (R,S,R)-stereoisomer of alpha-tocopherol.


tocol

A chromanol with a chroman-6-ol skeleton that is substituted at position 2 by a saturated or triply-unsaturated hydrocarbon chain consisting of three isoprenoid units.


Tocopherols

A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.


alpha-Tocotrienol

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a farnesyl chain at position 2. It has been found in palm oil derived from Elaeis guineensis.


(-)-alpha-Tocopherol

The (S,S,S)-stereoisomer of alpha-tocopherol.


(S,R,R)-alpha-Tocopherol

The (S,R,R)-stereoisomer of alpha-tocopherol.


Aquasol E

The (R,S,S)-stereoisomer of alpha-tocopherol.


gamma-Tocotrienol

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2. A vitamin E family member that has potent anti-cancer properties against a wide-range of cancers.


Mismatch Repair-Deficient Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by mismatch repair (MMR) deficiency caused by inactivating methylation or less frequently mutation of an MMR gene (MLH1, PMS2, MSH2, or MSH6).


C-14 demethylated eburicol


Malignant neoplasm of exocervix

A malignant neoplasm that affects the exocervix.


carboxamidine

Compounds having the structure RC(=NR)NR2. The term is used as a suffix in systematic nomenclature to denote the -C(=NH)NH2 group including its carbon atom.


Pyrantel

A carboxamidine that is 1,4,5,6-tetrahydropyrimidine that is substituted at position 1 by a methyl group and at position 2 by an (E)-2-(2-thienyl)vinyl group. It is used, particularly as the embonate [4,4'-methylenebis(3-hydroxy-2-naphthoate)] salt, as an anthelmintic that is effective against intestinal nematodes including threadworms, roundworms and hookworms, and is included in the WHO 'Model List of Essential Medicines'.


onium cation

Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families.


chlorobenzophenone

A member of the class of benzophenones that is any substituted benzophenone in which at least one of the substituents is a chlorine.


Silthiofam

A monocarboxylic acid amide obtained by formal condensation of the carboxy group from 4,5-dimethyl-2-(trimethylsilyl)thiophene-3-carboxlic acid with the amino group of allylamine. A fungicide seed dressing for cereals used mainly to control 'take-all'.


Stigmastanol

A 3-hydroxy steroid that is 5alpha-stigmastane which is substituted at the 3beta position by a hydroxy group.


anilines

Any  aromatic amine that is benzene carrying at least one amino substituent and its substituted derivatives.


(R)-aminoglutethimide

The (3R)-enantiomer of aminoglutethimide.


dimethylaniline

A methylaniline carrying at least two methyl groups.


A member of the class of pyrroles carrying a 2-amino-3-chlorophenyl substituent at position 3.


hydroxykynurenamine

Any kynurenamine carrying a hydroxy substituent.


amino-nitrotoluene

A nitrotoluene carrying at least one amino group.


hydroxykynurenine

A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.


methylaniline

A substituted aniline carrying one or more methyl groups at unspecified positions.


KYNURENINE

A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.


A member of the class of pyrroles carrying chloro and 2-amino-3-chlorophenyl substituents at positions 3 and 4 respectively.


Sapropterin dihydrochloride

The dihydrochloride salt of sapropterin. It is used for the diagnosis and treatment of variant forms of phenylketonuria (hyperphenylalaninaemia) associated with tetrahydrobiopterin deficiency. Natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthetase.


fluorenes

An ortho-fused polycyclic arene in which the skeleton is composed of two benzene rings ortho-fused to cyclopentane.


tetrol

A polyol that contains 4 hydroxy groups.


A hydroxycalciol that is a synthetic fluorinated and deuterated analogue of vitamin D3 which exhibits vitamin D receptor superagonist and anti-cancer activity.


1alpha,23(S),25-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) bearing additional hydroxy substituents at positions 1, 23 and 25 (with 1alpha,23S-configuration). An intermediate in the degradation pathway of 1alpha,25-(OH)2D3.


(20S,23,24)-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration), 23 and 24.


A vitamin D that is 19-norcalcitriol carrying an additional 3-hydroxypropyl substituent at position 2. A synthetic analogue of vitamin D, it exhibits anticancer properties.


Nordihydroguaiaretic acid

A tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups. Masoprocol, the meso-form found in the leaves of the creosote bush (Larrea divaricata), is a potent lipoxygenase inhibitor.


Eldecalcitol

A hydroxycalciol that is calcitriol with a 3-hydroxypropoxy group at position 2.


(20S,23,25)-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration), 23 and 25.


A hydroxycalciol that is calcitriol with a 4-hydroxybutoxy group at position 2.


A 6-lactoyl-5,6,7,8-tetrahydropterin in which the stereocentre at position 6 has R-configuration.


diazine

The parent structure of the diazines.


Pyrazine

A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.


An  oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.


A glycerophosphoethanolamine that is sn-glycero-3-phosphoethanolamine in which positions 1 and 2 are substituted by unspecified acyl and alkyl groups, and in which the positions of the acyl and alkyl groups are also unspecified.


4-(2-phenylethylsulfamoyl)-1H-pyrrole-2-carboxylic acid methyl ester


1-Hexyl-3-methylimidazolium chloride

An organic chloride salt in which the cationic component is 1-hexyl-3-methylimidazolium.


L-Mannitol

The L-enantiomer of mannitol.


asthma-related traits, susceptibility to, 8


Aurachin C

A C-type aurachin that is quinolin-4-one which is substituted by a hydroxy group at positions 1, a methyl group at position 2, and a triprenyl group at position 3.


An (S)-nicotine N(1')-oxide in which the N(1')-methyl group is on the opposite side of the pyrrolidine ring to the pyridine substituent. The major species at pH 7.3.


pyrrolidine N-oxides

Any member of the class of pyrrolidines that are substituted by an organyl group at position 1 and in which the amino group of the pyrrolidine ring has been oxidised to give the corresponding N-oxide.


A nicotine N(1')-oxide resulting from the oxidation of the pyrrolidine nitrogen of (S)-nicotine; major species at pH 7.3.


An (S)-nicotine N(1')-oxide in which the N(1')-methyl group is on the same side of the pyrrolidine ring as the pyridine substituent. The major species at pH 7.3.


Cinanserin hydrochloride

The hydrochloride salt of cinanserin. It is an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus (SARS-Cov) and reduces virus replication in vitro.


(R)-2-hydroxy-3-methylbutanoic acid

The R-enantiomer of 2-hydroxy-3-methylbutyric acid.


diphenylethane

Compounds containing two phenyl groups connected by an ethyl linker.


benzoins

An aromatic ketone containing a benzoin (2-hydroxy-1,2-diphenylethanone) skeleton.


carbonate ester

Any carbonate that is carbonic acid in which the hydrogens have been replaced by organyl groups.


Spiropidion

An azaspiro compound that is 1-methoxypiperidine which is fused at position 4 to the 5-position of a 1,5-dihydro-2H-pyrrol-2-one that is substituted at positions 1, 3 and 4 by methyl, 4-chloro-2,6-dimethylphenyl and (ethoxycarbonyl)oxy groups, respectively. It is a proinsecticide developed by Syngenta and used to protect a wide range of crops from some of the most damaging, difficult to control sucking pests such as aphids, whiteflies, Pysllids, armoured scales, soft scales, spider mites, rust mites, and red mites including California red scale, green peach aphid (Myzus persicae), tobacco whitefly etc.


SPIROTETRAMAT

An azaspiro compound that is methoxycyclohexane which is fused at position 4 to the 5-position of a 1,5-dihydro-2H-pyrrol-2-one that is substituted at positions 3 and 4 by 2,5-dimethylphenyl and (ethoxycarbonyl)oxy groups, respectively (the cis isomer). It is a proinsecticide (via hydrolysis of the ethyl carbonate group to give the corresponding 4-hydroxypyrrol-2-one, "spirotetramat-enol") and is used for the control of a wide range of sucking insects on fruit and potato crops.


A 1-methyl-4-pyridone-5-carboxamide with 2 deuterium atoms replacing 2 hydrogen atoms.


(s)-Salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has S configuration.


(r)-Salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has R configuration.


methylcytidine

Any member of the class of cytidines that is cytidine substituted by at least one methyl group.


D-fructofuranose 6-phosphate

The five-membered ring form of D-fructose 6-phosphate.


Colorectal Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm that arises from the colon or rectum.  It is characterized by a proliferation of neoplastic spindle cells.


An unsymmetrical C3 cyanine dye having benzothiazolium-2-yl and quinolinium-4-yl substituents.


A member of the class of benzofurans consisting of a 1-benzofuran skeleton and its substituted derivatives thereof.


hydroxybenzoic acid

Any benzoic acid carrying one or more phenolic hydroxy groups on the benzene ring.


3-Amino-5-hydroxybenzoic acid

A monohydroxybenzoic acid that is 3-hydroxybenzoic acid carrying an additional amino substitutent at position 4.


3-Amino-4-hydroxybenzoic acid

A monohydroxybenzoic acid that is 4-hydroxybenzoic acid carrying an additional amino substitutent at position 3.


3-Amino-2,4-dihydroxybenzoic acid

An aminobenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 4, and by an amino group at position 3.


4-Methyl-3-hydroxyanthranilic acid

An aminobenzoic acid that is anthranilic acid substituted by a hydroxy group at position 3 and a methyl group at position 4.


monohydroxybenzoic acid

Any hydroxybenzoic acid having a single phenolic hydroxy substituent on the benzene ring.


dihydroxybenzoic acid

Any member of the class of  hydroxybenzoic acids carrying  two phenolic hydroxy groups on the benzene ring and its derivatives.


phosphatidylethanolamine 36:2

A phosphatidylethanolamine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 2 double bonds.


A phosphatidylethanolamine 36:2 in which both acyl groups have 18 carbons and 1 double bond each (position not specified).


A glycerophosphoethanolamine compound having an alk-1-enyl substituent at the 1-position and an acyl substituent at the 2-position.


The hydrochloride salt of (R)-bromazine.


Stage IA Hepatocellular Carcinoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Solitary tumor equal to or less than 2 cm.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage I Hepatocellular Carcinoma AJCC v8

Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0). T1a: Solitary tumor equal to or less than 2 cm.  T1b: Solitary tumor larger than 2 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IB Hepatocellular Carcinoma AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Solitary tumor larger than 2 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Potassium Chloride

A metal chloride salt with a K(+) counterion.


Potassium fluoride

A fluoride salt having K+ as the counterion.


Mepivacaine hydrochloride

The hydrochloride salt of mepivacaine. It is used as a local anaesthetic.


Withalongolide B

A withanolide that is 27-deoxywithaferin A substituted by a hydroxy group at position 19. Isolated from Physalis longifolia, it exhibits antineoplastic activity.


Digoxigenin

A hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis.


A C5 cyanine dye having 1-ethyl-3,3-dimethylindoleinine units at each end.


A phosphatidylcholine having an alpha-linolenoyl at sn-2 and a fatty acyl chain of unknown composition at sn-1. Major species at pH 7.3.


Stage IIIB Cervical Cancer AJCC v8

Stage IIIB includes: T3b, Any N, M0. T3b: extending to pelvic wall and/or causing hydronephrosis or nonfunctioning kidney. M0: No distant metastasis. (AJCC 8th Ed.)


poly(allylamine hydrochloride)

A polymer composed of propan-1-amine hydrochloride units.


Ponatinib hydrochloride

The hydrochloride salt of ponatinib. It is a potent pan inhibitor of tyrosine kinases, active in all single resistance ABL kinase mutations including the T315l mutation. It is approved for the treatment of chronic myeloid leukemia.


Stage II Rectosigmoid Cancer AJCC v7

Stage II includes: IIA (T3, N0, M0); IIB (T4a, N0, M0); IIC (T4b, N0, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


D-phenylalanine

The D-enantiomer of phenylalanine.


The (R)-enantiomer of bethanechol chloride.


Recurrent Rectal Cancer

The reemergence of rectal carcinoma after a period of remission.


Rectal adenocarcinoma recurrent

The reemergence of rectal adenocarcinoma after a period of remission.


polyatomic cation

A cation consisting of more than one atom.


A lysophosphatidylcholine(0:0/16:1) in which the 2-acyl group is specified as (9Z)-hexadecenoyl.


phosphocholines

Any compound having phosphocholine as part of its structure.


phosphatidylcholine 38:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 2 double bonds.


phosphatidylcholine O-30:1

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 30 carbons and 1 double bond.


phosphatidylcholine (P-36:2)

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the unspecified alk-1-enyl and acyl groups at positions 1 and 2 contain 36 carbon atoms in total with 2 additional double bonds in the acyl moiety.


phosphatidylcholine

A glycerophosphocholine that is glycero-3-phosphocholine bearing two acyl substituents at positions 1 and 2.


phosphatidylcholine 42:8

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 8 double bonds.


The conjugate base of a 1,2-diacyl-sn-glycero-3-phosphocholine compound formed by deprotonation of the phosphate OH group.


lysophosphatidylcholine 14:0

A lysophosphatidylcholine in which the remaining acyl group is specified as tetradecanoyl (myristoyl). If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine.  If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


sphingomyelin 42:2

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 42 with 2 double bonds.


A phosphatidylcholine 38:3 in which the acyl groups at positions 1 and 2 are specified as stearoyl (octadecanoyl) and icosatrienoyl respectively.


sphingomyelin 36:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 36 with 1 double bond.


sphingomyelin 42:0

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 42 with 0 double bonds.


A 1-acyl-sn-glycero-3-phosphocholine in which the 1-acyl group contains 18 carbons and 2 double bonds.


An alkyl,acyl-sn-glycero-3-phosphocholine in which unspecified acyl and alkyl groups are located at positions 1 and 2 respectively.


Benzododecinium

A quaternary ammonium ion obtained by methylation of N-benzyl-N-methyldodecan-1-amine.


A 1,2-diacyl-sn-glycero 3-phosphocholine in which the acyl group at position 1 is unspecified while that at position 2 is specified as arachidonoyl


phosphatidylcholine 38:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 1 double bond.


A 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphocholine in which the 2-acyl substituent is specified as oleoyl.


A 1-acyl-sn-glycero-3-phosphocholine in which the 1-acyl group contains 20 carbons and 4 double bonds.


Any member of the class of lysophosphatidylcholines which has a free hydroxy group at the 1-position of the glycerol moiety.


A 1,2-diacyl-sn-glycero-3-phosphocholine where the acyl group at position 1 is unspecified while the acyl group at position 2 is palmitoleoyl.


lysophosphatidylcholine 20:5

A lysophosphatidylcholine in which the acyl group contains 20 carbons and 5 double bonds. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


A lysophosphatidylcholine 22:6 in which the docosahexaenoyl group is located at position 1.


lysophosphatidylcholine 18:3

An acyl-sn-glycero-3-phosphocholine in which the acyl group contains 18 carbons with 3 double bonds. If R1 is an acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is an acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


lysophosphatidylcholine 16:0

A lysophosphatidylcholine in which the acyl group has a fully saturated C16 chain and is attached to the glycero moiety at either position 1 or 2.


lysophosphatidylcholine 22:4

A lysophosphatidylcholine in which the acyl group (position not specified) contains 22 carbons and 4 double bonds.


A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the alkenyl group has Z geochemistry.


A sphingomyelin in which the total number of carbons in the fatty acyl group is 22 with 1 double bond.


phosphatidylcholine 36:3

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 3 double bonds.


A sphingomyelin d18:1 in which the ceramide N-acyl group contains 22 carbons, 1 hydroxy group and 2 double bonds.


phosphatidylcholine 42:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 4 double bonds.


phosphatidylcholine (P-34:2)

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the unspecified alk-1-enyl and acyl groups at positions 1 and 2 contain 34 carbon atoms in total with 2 additional double bonds in the acyl moiety.


phosphatidylcholine 40:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total with 1 double bond.


A sphingomyelin d18:1 in which the ceramide N-acyl group contains 22 carbons, 1 hydroxy group and 1 double bond.


phosphatidylcholine O-34:2

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 34 carbons and 2 double bonds.


phosphatidylcholine O-38:6

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 38 carbons and 6 double bonds.


The ammonium betaine of a 2-acyl-sn-glycero-3-phosphocholine arising from deprotonation of the phosphate OH; major species at pH 7.3.


phosphatidylcholine 36:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total and 2 double bonds.


A 2-acyl-sn-glycero-3-phosphocholine in which the 2-acyl group contains 16 carbons and is fully saturated.


phosphatidylcholine O-42:0

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 42 carbons and 0 double bonds.


phosphatidylcholine 42:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 5 double bonds.


phosphatidylcholine O-38:5

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 38 carbons and 5 double bonds.


A sphingomyelin having sphinganine as the sphingoid component.


Edelfosine, (S)-

A 1-octadecyl-2-methylglycero-3-phosphocholine that is the (S)-enantiomer of edelfosine.


sphingomyelin 34:0

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 34 with 0 double bonds.


phosphatidylcholine O-36:0

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 36 carbons and 0 double bonds.


phosphatidylcholine O-42:3

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 42 carbons and 3 double bonds.


monoalkylglycerophosphocholine

A glycerophosphocholine that is glycero-3-phosphocholine bearing a single alkyl substituent at an unspecified position (sn-1, sn-2, or sn-3).


phosphatidylcholine 40:10

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the two acyl groups contain a total of 40 carbons and 10 double bonds.


The ammonium betaine formed from 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine by deprotonation of the phosphate OH group.


phosphatidylcholine O-38:0

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 38 carbons and 0 double bonds.


phosphatidylcholine 34:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 34 carbons in total with 1 double bond.


phosphatidylcholine 40:7

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total with 7 double bonds.


An alkyl,acyl-sn-glycero-3-phosphocholine in which unspecified alkyl and acyl groups are located at positions 1 and 2 respectively.


A phosphatidylcholine 36:4 in which the acyl groups at positions 1 and 2 are octadecadienoyl with double bonds at unspecified positions.


phosphatidylcholine 42:9

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 9 double bonds.


A 1-acyl-2-alkyl-sn-glycero-3-phosphocholine in which the 2-alkyl moiety can be any alk-1-enyl group.


phosphatidylcholine 34:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 34 carbons in total with 2 double bonds.


Any member of the class of lysophosphatidylcholines which has a free hydroxy group at the 2-position of the glycerol moiety.


phosphatidylcholine O-30:0

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 30 carbons and 0 double bond.


lysophosphatidylcholine 18:4

A lysophosphatidylcholine in which the acyl group (position not specified) contains 18 carbons and 4 double bonds.


lysophosphatidylcholine 22:1

A lysophosphatidylcholine in which the remaining acyl group contains 22 carbons and 1 double bond. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


A 2-acyl-1-alkyl-sn-glycero-3-phosphocholine where the 2-O-acyl component is specifed as arachidonoyl.


sphingomyelin 36:2

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 36 with 2 double bonds.


lysophosphatidylcholine 15:0

An acyl-sn-glycero-3-phosphocholine in which the acyl group contains fifteen carbons with no double bonds and is attached to the glycero moiety at either position 1 or 2.


lysophosphatidylcholine 18:0

A lysophosphatidylcholine in which the acyl group has a fully saturated C18 chain and is attached to the glycero moiety at either position 1 or 2.


sphingomyelin 30:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 30 with 1 double bond.


phosphatidylcholine 33:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups specified at C-1 and C-2 contain 33 carbons in total with 1 double bond.


A lysophosphatidylcholine with defined stereochemistry where the position of the acyl group is unknown.


The conjugate base of a 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine compound formed by deprotonation of the phosphate OH group.


sphingomyelin 34:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 34 with 1 double bond.


Lysophosphatidylcholine

An acylglycerophosphocholine resulting from partial hydrolysis of a phosphatidylcholine, which removes one of the fatty acyl groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.


lysophosphatidylcholine 20:0

A lysophosphatidylcholine in which the remaining acyl group contains 20 carbons and 0 double bonds. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


phosphatidylcholine P-36:5

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the alk-1-enyl and acyl groups at positions 1 and 2 contain 36 carbon atoms in total with 5 additional double bonds.


phosphatidylcholine O-40:6

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 40 carbons and 6 double bonds.


phosphatidylcholine 42:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 1 double bond.


A glycerophosphocholine that is sn-glycero-3-phosphocholine in which positions 1 and 2 are substituted by unspecified acyl and alkyl groups, and in which the positions of the acyl and alkyl groups are also unspecified.


A monoalkylglycerophosphocholine in which the alkyl group may be attached to the sn-1 or sn-3 position.


A sphingomyelin 41:2 obtained by formal condensation of the carboxy group of any tetracosenoic acid with the amino group of hexadecasphingosine-1-phosphocholine.


lysophosphatidylcholine 22:2

A lysophosphatidylcholine in which the remaining acyl group contains 22 carbons and 2 double bonds. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


sphingomyelin d18:1/16:0

A sphingomyelin d18:1 in which the fatty acyl group contains 16 carbons and is fully saturated.


phosphatidylcholine 28:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 28 carbons in total with 2 double bonds.


A glycerophosphocholine having an unspecified acyl group attached at the 2-position.


phosphatidylcholine 33:0

A phosphatidylcholine in which the two acyl groups contain a total of 33 carbons and no double bonds.


An ammonium ion that is the conjugate acid of pyridoxamine arising from selective protonation of the primary amino group; major species at pH 7.3.


phosphatidylcholine 40:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total with 5 double bonds.


(S)-Bethanechol

The (S)-enantiomer of bethanechol.


lysophosphatidylcholine 22:6

An acyl-sn-glycero-3-phosphocholine in which the acyl group (position not specified) contains 22 carbons with 6 double bonds.


A glycerophosphocholine that is glycero-3-phosphocholine bearing a single alkenyl group located at position 1.


phosphatidylcholine 30:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 30 carbons in total with 2 double bonds.


phosphatidylcholine 42:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 0 double bonds.


A lysophosphatidylcholine in which the acyl group (position not specified) is linoleoyl.


phosphatidylcholine O-44:5

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 44 carbons and 5 double bonds.


A lysophosphatidylcholine 16:1 in which the acyl group is specified as (9Z)-hexadecenoyl and is located at either position 1 or 2.


A 1,2-diacyl-sn-glycero-3-phosphocholine where the acyl group at position 1 is unspecified while the acyl group at position 2 is palmitoyl.


lysophosphatidylcholine (22:5/0:0)

A lysophosphatidylcholine 22:5 in which the acyl group is located at position 1.


phosphatidylcholine 34:3

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 34 carbons in total with 3 double bonds.


sphingomyelin 40:2

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 40 with 2 double bonds.


A glycero-3-phosphocholine compound having an alk-1-enyl substituent at the 1-position and an acyl substituent at the 2-position.


phosphatidylcholine 38:6

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 6 double bonds.


phosphatidylcholine O-34:0

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 34 carbons and 0 double bonds.


A glycerophosphocholine that is sn-glycero-3-phosphocholine bearing a single alkyl substituent at an unspecified position (either R(1) = H, R(2) = alkyl or R(1) = alkyl, R(2) = H).


phosphatidylcholine 38:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 4 double bonds.


phosphatidylcholine 32:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 1 double bond.


An sn-glycero-3-phosphocholine substituted at the 1-oxygen by an alk-1-enyl group.


lysophosphatidylcholine 22:5

A lysophosphatidylcholine in which the acyl group (position not specified) contains 22 carbons with 5 double bonds.


A sphingomyelin d18:1 in which the ceramide N-acyl group contains 16 carbons, 1 hydroxy group and 1 double bond.


phosphatidylcholine (20:3/22:6)

A phosphatidylcholine 42:9  in which the fatty acyl groups at positions 1 and 2 are specified as C20:3 and C22:6 respectively.


sphingomyelin d18:1/18:1

A sphingomyelin d18:1 in which the fatty acyl group contains 16 carbons and 1 double bond


phosphatidylcholine 32:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 2 double bonds.


phosphatidylcholine 34:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 34 carbons in total with 0 double bonds.


phosphatidylcholine 36:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 4 double bonds.


phosphatidylcholine 37:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 37 carbons in total with 5 double bonds.


phosphatidylcholine 29:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at positions 1 and contain a total of 29 carbons and no double bonds.


sphingomyelin 32:1

A sphingomyelin in which the total number of carbons in the sphingoid base (R1) and fatty acyl (R2) groups is 32 with 1 double bond.


phosphatidylcholine 34:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 34 carbons in total with 4 double bonds.


phosphatidylcholine 36:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 1 double bond.


Tiquizium

A member of the class of quinolizines that is trans-5-methyloctahydro-2H-quinolizinium which is substituted by a di(thiophen-2-yl)methylidene group at position 3. Its bromide salt is used as an antispasmodic drug.


lysophosphatidylcholine 16:1

An lysophosphatidylcholine in which the acyl group is hexadecenoyl (position of double bond not specified). If R1 is hexadecenoyl and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is hexadecenoyl then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


lysophosphatidylcholine 20:1

A lysophosphatidylcholine in which the remaining acyl group contains 20 carbons and 1 double bond. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


phosphatidylcholine (18:2/22:6)

A phosphatidylcholine 40:8 in which the fatty acyl groups at positions 1 and 2 are specified as C18:2 and C22:6 respectively.


phosphatidylcholine 36:6

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 6 double bonds.


A phosphatidylcholine 36:1 in which the acyl groups aspecified at positions 1 and 2 are octadecanoyl and octadecenoyl (double bond at unspecified position) respectively.


phosphatidylcholine 38:8

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the two acyl groups contain a total of 38 carbons and 8 double bonds.


phosphatidylcholine 31:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the two acyl groups contain a total of 31 carbons and no double bonds.


A phosphatidylcholine having an alpha-linolenoyl at sn-1 and a fatty acyl chain of unknown composition at sn-2. Major species at pH 7.3.


phosphatidylcholine 38:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 5 double bonds.


lysophosphatidylcholine 20:2

A lysophosphatidylcholine in which the remaining acyl group contains 20 carbons and 2 double bonds. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


lysophosphatidylcholine 17:0

An  lysophosphatidylcholine in which the acyl group contains seventeen carbons and no double bonds. If R1 is an acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphoethanolaminecholine. If R1 is a hydrogen and R2 is an acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


lysophosphatidylcholine (18:1/0:0)

A lysophosphatidylcholine 18:1 in which the acyl group is located at position 1.


A glycerophosphocholine that consists of L-alpha-glycerophosphocholine carrying an unspecified alkyl substituent at position 1.


A phosphatidylcholine 36:2 in which the acyl group both at positions 1 and 2 is octadecenoyl with double bond at unspecified position.


A phosphatidylcholine having a linoleoyl at sn-1 and a fatty acyl chain of unknown composition at sn-2. Major species at pH 7.3.


glycerophosphocholine

The glycerol phosphate ester of a phosphocholine. A nutrient with many different roles in human health.


A phosphatidylcholine 32:1 in which one acyl group has 16 carbons and is fully saturated while the other has 16 carbons and 1 double bond (position not specified).


sphingomyelin 41:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 41 with 1 double bond.


A 2-acyl-sn-glycero-3-phosphocholine in which the 2-acyl group contains 18 carbons and is fully saturated.


phosphatidylcholine 35:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 35 carbons in total with 5 double bonds.


lysophosphatidylcholine 20:4

An acyl-sn-glycero-3-phosphocholine in which the remaining acyl group (position not specified) contains 20 carbons with 4 double bonds.


N-Trimethyllysine

An alpha-amino-acid cation that is the N(6)-trimethyl derivative of L-lysine.


phosphatidylcholine (P-38:4)

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the unspecified alk-1-enyl and acyl groups at positions 1 and 2 contain 38 carbon atoms in total with 4 additional double bonds in the acyl moiety.


Aclidinium

A carboxylic ester obtained by formal condensation between the carboxy group of 2-hydroxy(di-2-thienyl)acetic acid and the hydroxy group of N-(3-phenoxypropyl)-3-quinuclidinol. Used as its bromide salt for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD).


A 1-O-(alk-1-enyl)-sn-glycero-3-phosphocholine in which the alkenyl group has Z geochemistry.


phosphatidylcholine 28:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 28 carbons in total with 0 double bonds.


lysophosphatidylcholine (P-16:0/0:0)

A 1-O-(alk-1-enyl)-sn-glycero-3-phosphocholine in which the alk-1-enyl group contains 16 carbons and no additional double bonds.


phosphatidylcholine 30:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 30 carbons in total with 0 double bonds.


phosphatidylcholine 38:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons in total with 0 double bonds.


lysophosphatidylcholine 18:1

A lysophosphatidylcholine in which the remaining acyl group (position not specified) contains 18 carbons with 1 double bond.


phosphatidylcholine 29:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 28 carbons in total with 1 double bond.


sphingomyelin 41:2

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 41 with 2 double bonds.


ammonium ion derivative

A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).


lysophosphatidylcholine 18:2

A lysophosphatidylcholine in which the acyl group (position not specified) contains 18 carbons and 2 double bonds.


phosphatidylcholine 40:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total with 2 double bonds.


phosphatidylcholine O-44:3

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 44 carbons and 3 double bonds.


phosphatidylcholine 30:1

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 30 carbons in total with 1 double bond.


A sphingomyelin in which the total number of carbons in the fatty acyl group is 26 with 1 double bond.


phosphatidylcholine 36:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total and 0 double bonds.


phosphatidylcholine 32:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 0 double bonds.


phosphatidylcholine 35:3

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 35 carbons in total with 3 double bonds.


A primary ammonium ion that is the conjugate acid of thiamine(1+) resulting from the protonation of the primary amino group.


A 1,2-diacyl-sn-glycero-3-phosphocholine in which the 1-acyl group is specified as palmitoyl.


phosphatidylcholine O-32:2

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 32 carbons and 2 double bonds.


A sphingomyelin in which the total number of carbons in the fatty acyl group is 24 with 1 double bond.


sphingomyelin d18:1

Any sphingomyelin having sphingosine as the sphingoid component.


lysophosphatidylcholine 20:3

A lysophosphatidylcholine in which the acyl group contains 20 carbons with 3 double bonds. If R1 is an acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is an acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


phosphatidylcholine P-40:6

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the alk-1-enyl and acyl groups contain a total of 40 carbon atoms with 6 additional double bonds.


phosphatidylcholine 32:3

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 3 double bonds.


A glycerophosphocholine that is glycero-3-phosphocholine carrying unspecified alk-1-enyl and acyl groups at positions 1 and 2 respectively. Major species at pH 7.3.


A lysophosphatidylcholine 20:1 in which the acyl group is located at position 1.


phosphatidylcholine 42:6

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 6 double bonds.


sphingomyelin 38:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 38 with 1 double bond.


phosphatidylcholine O-40:0

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 40 carbons and 0 double bonds.


sphingomyelin 44:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 44 with 1 double bond.


(R)-Bethanechol

The (R)-enantiomer of bethanechol.


acylcholine

A choline ester formed from choline and a carboxylic acid.


phosphatidylcholine 33:2

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 33 carbons in total with 2 double bonds.


phosphatidylcholine 36:5

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total with 5 double bonds.


lysophosphatidylcholine 24:0

A lysophosphatidylcholine in which the remaining acyl group (position not specified) contains 24 carbons and 0 double bonds.


A 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine in which the 2-acyl group has 20 carbons and 3 double bonds.


A glycerophosphocholine that is glycero-3-phosphocholine carrying one alkyl and one acyl group in unspecified positions. Major species at pH 7.3.


sphingomyelin 42:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 42 with 1 double bond.


An N-acylsphinganine-1-phosphocholine obtained by formal condensation of the carboxy group of any octadecenoic acid with the amino group of sphinganine-1-phosphocholine.


lysophosphatidylcholine 24:1

A lysophosphatidylcholine in which the remaining acyl group (position not specified) contains 24 carbons and 1 double bond.


lysophosphatidylcholine 20:3/0:0

A 1-O-acyl-sn-glycero-3-phosphocholine in which the acyl group at C-1 contains 20 carbons and 3 double bonds.


phosphatidylcholine (18:0/22:5)

A 1,2-diacyl-sn-glycero-3-phosphocholine in which one acyl group has 18 carbons and is fully saturated while the other has 22 carbons and 5 double bonds.


sphingomyelin 44:2

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 44 with 2 double bonds.


sphingomyelin 40:1

A sphingomyelin in which the total number of carbons in the sphingoid base and fatty acyl groups is 40 with 1 double bond.


phosphatidylcholine 40:8

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total with 8 double bonds.


An alkylacylglycero-3-phosphocholine in which the alkyl and acyl groups are located at positions 1 and 2 respectively. Major species at pH 7.3.


phosphatidylcholine 38:3

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 38 carbons with 3 double bonds.


A 1-(alk-1-enyl)-2-oleoyl-sn-glycero-3-phosphocholine in which the alk-1-enyl group has Z geochemistry.


phosphatidylcholine O-38:4

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 38 carbons and 4 double bonds.


A sphingomyelin d18:1 in which the ceramide N-acyl group contains 24 carbons, 1 hydroxy group and 1 double bond.


A 1-acyl-2-alkyl-sn-glycero-3-phosphocholine in which the acyl and alkyl groups at positions 1 and 2 are specified respectively as arachidonoyl and palmityl.


A 1-octadecyl-2-methylglycero-3-phosphocholine that is the (R)-enantiomer of edelfosine.


phosphatidylcholine (22:4/20:4)

A phosphatidylcholine 42:8 in which the fatty acyl groups at positions 1 and 2 are specified as C22:4 and C20:4 respectively. The positions of the double bonds are unspecified.


phosphatidylcholine 40:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 40 carbons in total and 4 double bonds.


cholines

A quaternary ammonium ion based on the choline ion and its substituted derivatives thereof.


The ammonium betaine of a 1-O-acyl-sn-glycero-3-phosphocholine arising from deprotonation of the phosphate OH; major species at pH 7.3.


lysophosphatidylcholine 14:1

A lysophosphatidylcholine in which the remaining acyl group contains 14 carbons and 1 double bond. If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine. If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


phosphatidylcholine O-34:1

A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 34 carbons and 1 double bond.


lysophosphatidylcholine (22:4/0:0)

A lysophosphatidylcholine 22:4 in which the docosatetraenoyl group is located at position 1.


A sphingomyelin  d18:1 in which the ceramide N-acyl group contains 14 carbons, 1 hydroxy group and 1 double bond.


phosphatidylcholine O-30:2

An alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 30 carbons and 2 double bonds.


phosphatidylcholine 37:4

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 37 carbons in total with 4 double bonds.


sphingomyelin

Any of a class of phospholipids in which the amino group of a sphingoid base is in amide linkage with one of several fatty acids, while the terminal hydroxy group of the sphingoid base is esterified to phosphorylcholine.


phosphatidylcholine 40:6

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the two acyl groups contain forty carbons in total with six double bonds.


quaternary ammonium ion

A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.


Stage IIIB Cervical Cancer FIGO 2018

Cervical carcinoma with extension to the pelvic wall and/or hydronephrosis or nonfunctioning kidney (unless known to be due to another cause). (FIGO 2018)


Extramedullary Disease in Plasma Cell Myeloma Involving the Liver

Infiltration of the hepatic sinusoids by malignant (clonal) plasma cells in patients with history of plasma cell myeloma.


A secondary amino compound that is ammonia in which nitrogen is substituted by a 1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl group and a 2-(2-ethoxyphenoxy)ethyl group.


alpha-D-galactoside

Any D-galactoside having alpha-configuration at its anomeric centre.


icosatetraenoic acid

A 20-carbon, polyunsaturated fatty acid having four double bonds at unspecified positions.


Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.


Magnesium chloride hexahydrate

A hydrate that is the hexahydrate form of magnesium dichloride.


paraben

A 4-hydroxybenzoate ester in which the esterifying alcohol is an alkanol (in diagram, R = alkyl). Commonly used as preservatives in cosmetic and pharmaceutical products.


A 3beta-hydroxy steroid that is cathasterone which is lacking the oxo substituent at position 6.


Resectable Colon Carcinoma

Colon carcinoma that is amenable to surgical resection.


Localized Resectable Adult Hepatocellular Carcinoma

A localized hepatocellular carcinoma that occurs during adulthood and it is amenable to surgical resection.


Resectable Colorectal Carcinoma

Colorectal carcinoma that is amenable to surgical resection.


Carcinoma liver resectable

A hepatocellular carcinoma that is amenable to surgical resection.


A 4-hydroxy-D-proline in which the hydroxy group at position 4 has S-configuration.


An androstanoid that is testosterone substituted at C2  by a hydroxy group with undefined stereochemistry.


An androstanoid that is testosterone carrying an additional hydroxy substituent at the 2beta-position.


Tubocapsanolide F

A  withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 17 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Tubocapsicum anomalum, it exhibits cytotoxic activity.


allylamine antifungal drug

An organonitrogen compound that contains an amino group that is attached to a carbon which is itself attached to an olefinic carbon and which has been used as an antifungal drug.


Terbinafine hydrochloride

A hydrochloride obtained by reaction of terbinafine with one molar equivalent of hydrogen chloride.


A hydrochloride salt resulting from the formal reaction of equimolar amounts of thiocyclam and hydrogen chloride. A nicotinic acetylcholine receptor agonist used as a broad-spectrum insecticide. Not approved for use within the European Union.


A 17-oxo steroid that is 5alpha-androstan-17-one substituted by a beta-hydroxy group at positions 3 and an alpha-hydroxy group at position 7.


Stage IA Cervical Cancer FIGO 2018

Invasive cervical carcinoma that can be diagnosed only by microscopy, with maximum depth of invasion less than 5 mm. (FIGO 2018)


Stage IA2 Cervical Cancer FIGO 2018

Cervical carcinoma with measured stromal invasion equal or more than 3 mm and less than 5 mm in depth. (FIGO 2018)


Stage IA1 Cervical Cancer FIGO 2018

Cervical carcinoma with measured stromal invasion less than 3 mm in depth. (FIGO 2018)


Quinoxaline

A naphthyridine in which the nitrogens are at positions 1 and 4.


A quinoxaline derivative  that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kgamma, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis.


An androstanoid that is 5alpha-dihydrotestosterone carrying an additional hydroxy susbstituent at position 19.


Rilpivirine hydrochloride

A hydrochloride obtained by reaction of rilpivirine with one equivalent of hydrochloric acid. Used for treatment of HIV.


Refractory Endometrial Dedifferentiated Carcinoma

Endometrial dedifferentiated carcinoma that is resistant to treatment.


Calciumchloridehexahydrate

A hydrate that is the hexahydrate form of calcium chloride.


Calcium dihydrate dichloride

A hydrate that is the dihydrate form of calcium chloride.


Stage IVB Rectal Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis.  (AJCC 8th ed.)


hexose phosphate

A phospho sugar that is formally obtained from a hexose.


fructose 6-phosphate

A ketohexose monophosphate consisting of fructose having a phosphate group located at the 6-position.


D-aldohexose 6-phosphate

Any D-aldose having a six-carbon chain with a phosphate group at C-6.


D-fructose 6-phosphate

A ketohexose monophosphate that is D-fructose having a phosphate substituent at position 6. It is an important intermediate in the carbohydrate metabolism.


D-Galactopyranose 1-phosphate

A D-galactose phosphate that consists of  D-galactopyranose having a single phospho substituent located at the 1-position. It is an intermediate obtained during the the galactose metabolism.


D-hexose phosphate

Any mono-phosphorylated D-hexose having a chain of six carbon atoms in the molecule.


tagatose 6-phosphate

A  ketohexose monophosphate that is tagatose attached to a phosphate group at position 6.


D-fructose 1,6-bisphosphate

A ketohexose bisphosphate that is D-fructose substituted by phosphate groups at positions 1 and 6. It is an intermediate in the glycolysis metabolic pathway.


A D-tagatofuranose 6-phosphate with a beta-configuration at the anomeric position.


A D-glucopyranose 6-phosphate where alpha-D-glucose is the sugar component.


alpha-D-hexose 1-phosphates

Any hexose-1-phosphate which has D configuration at position 5 and alpha-configuration at the anomeric centre.


D-mannose 6-phosphate

A mannose phosphate in which the phosphate group is attached to position 6.


D-Mannose 1-phosphate

A mannose phosphate that is D-mannose carrying a phosphate group at position 1.


D-fructofuranose 1-phosphate

The furanose form of D-fructose 1-phosphate.


D-Glucose 6-phosphate

A D-glucose monophosphate in which the phosphate group is attached to position 6.


D-fructofuranose 2,6-bisphosphate

A ketohexose bisphosphate that is D-fructofuranose carrying phosphate groups at positions 2 and 6.


alpha-D-tagatofuranose 6-phosphate

A D-tagatofuranose 6-phosphate with an alpha-configuration at the anomeric position.


D-fructose 1-phosphate

The D-enantiomer of fructose 1-phosphate.


The pyranose form of D-mannose 6-phosphate.


fructose 1-phosphate

A ketohexose monophosphate consisting of fructose having a phosphate group located at the 1-position


D-tagatose 1,6-bisphosphate

A ketohexose bisphosphate that is D-tagatose carrying phosphate groups at positions 1 and 6.


D-hexopyranose 6-phosphate

Any D-hexose 6-phosphate in which the hexose is in the pyranose form.


Glucose 1-phosphate

A D-glucose monophosphate in which the phosphate group is located at position 1.


D-fructofuranose 1,6-bisphosphate

The furanose form of D-fructose 1,6-bisphosphate.


Cervical Mucinous Adenocarcinoma, Not Otherwise Specified

A cervical mucinous adenocarcinoma in which more than 50% of malignant cells contain intracytoplasmic mucin. There is no evidence of gastric, intestinal, or signet ring cell differentiation.


glycerolipid

Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.


phosphatidylethanolamine

A class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxy group of ethanolamine.


A monoglyceride in which the acyl substituent is located at position 1.


A 3-sn-glycerophosphoserine compound having acyl substituents at the 1- and 2-hydroxy positions.


A 3-sn-phosphatidyl-L-serine in which the 1- and 2-acyl groups are octadecanoyl and octadecadienoyl respectively.


monoacylglycerol 16:0

A monoglyceride in which the acyl group contains a total of 16 carbon atoms and 0 double bond.


phosphatidylethanolamine 36:0

A phosphatidylethanolamine in which the two acyl groups contain a total of 36 carbons and no double bonds.


phosphatidylinositol phosphate

Any member of the phosphoinositide family of compounds, of which seven occur naturally.


A phosphatidylethanolamine in which the phosphatidyl acyl group at C-1 and C-2 is stearoyl.


monoradylglycerol

Any lipid that is glycerol bearing a single acyl, alkyl or alk-1-enyl substituent at an unspecified position.


An optically active form of phosphatidylethanolamine having R-configuration.


lysophosphatidylethanolamine 20:3

An acyl-sn-glycero-3-phosphoethanolamine in which the acyl group contains twenty carbons with three double bonds and is attached to the glycero moiety at either position 1 or 2.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl group at position 1 is unspecified while that at position 2 is specified as myristoyl (tetradecanoyl).


phosphatidylserine 40:5

A 3-sn-phosphatidyl-L-serine in which the two acyl groups contain a total of 40 carbon atoms and 5 double bonds.


A diacylglycerolipid where the fatty acyl at sn-1 has a saturated bond between carbons 1 and 2, the glycerolipid part is unkown, R3 can be an H or a phospholipid.


A triglyceride where at least one of R1, R2 or R3 is a linoleoyl group. Formula is C23H36O6R2


monoacylglycerol 22:5

A monoglyceride in which the acyl groups contain a total of 22 carbons and 5 double bonds.


A 3-sn-phosphatidyl-L-serine in which the 1- and 2-acyl groups are octadecenoyl groups.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl group at position 1 is unspecified while that at position 2 is specified as palmitoyl (hexadecanoyl).


triacylglycerol 64:16

A triglyceride in which the three acyl groups contain a total of 64 carbons and 16 double bonds.


1-lysophosphatidic acid

Any member of the class of lysophosphatidic acids which has a free hydroxy group at the 1-position of the glycerol moiety.


An ether lipid consisting of glycerol substituted at position 2 by an acetyl group and at position 1 by an unspecified alkyl group.


A lysophosphatidylethanolamine 22:4 in which the acyl group is located at position 1.


triacylglycerol 46:1

A triglyceride in which the three acyl groups contain a total of 46 carbons and 1 double bond.


phosphatidylethanolamine 37:2

A phosphatidylethanolamine in which the two acyl groups contain a total of 37 carbons and 2 double bonds.


phosphatidylethanolamine 44:8

A phosphatidylethanolamine in which the two acyl groups contain a total of 44 carbons and 8 double bond.


monoacylglycerol phosphate

Derivatives of phosphoglycerols which have only one of the alcohol groups of the glycerol backbone ester-linked with a fatty acid.


An acyl-sn-glycero-3-phosphate in which a single acyl substituent is located at position 2.


1-acylglycerol 18:2

A 1-monoglyceride in which the acyl group contains 18 carbons and 2 double bonds.


2-acylglycerol 20:5

A 2-monoglyceride in which the acyl group contains 20 carbons and 5 double bonds.


CDP-diacylglycerol

A CDP-glycerol having unspecified acyl groups (most commonly fatty acyl groups) at the 1- and 2-positions.


triradylglycerol

A glycerol compound having one of three possible substituent groups - either acyl, alkyl, or alk-1-enyl - at each of the three possible positions sn-1, sn-2 or sn-3. has functional parent glycerol (CHEBI:17754), children: triglyceride (CHEBI:17855). Parent: is_a glycerolipid (CHEBI:35741)


triacylglycerol 52:7

A triglyceride in which the three acyl groups contain a total of 52 carbons and 7 double bonds.


phosphatidylserine 36:1

A 3-sn-phosphatidyl-L-serine in which the two acyl groups contain a total of 36 carbon atoms and 1 double bond.


lysophosphatidylethanolamine 20:1

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 20 carbons and 1 double bond.


phosphatidylethanolamine (18:1/22:6)

A phosphatidylethanolamine 40:7 in which the acyl group at C-1 contains 18 carbons and 1 double bond while that at C-2 contains 22 carbons and 6 double bonds.


1-acylglycerol 22:5

A 1-monoglyceride in which the acyl group contains 22 carbons and 5 double bonds.


monoacylglycerol 18:2

A monoglyceride in which the acyl groups contain a total of 18 carbons and two double bonds.


monoacylglycerol 20:4

A monoglyceride in which the acyl group contains a total of 20 carbon atoms and 4 double bonds.


glyceride

Any ester resulting from the condensation of one or more of the hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


A 3-sn-phosphatidyl-L-serine in which the 1- and 2-acyl groups are octadecanoyl and octadecenoyl respectively.


phosphatidylserine 36:4

A 3-sn-phosphatidyl-L-serine in which the two acyl groups contain a total of 36 carbon atoms and 4 double bonds.


alkyldiacylglyceride

A triradylglycerol with a single alkyl substituent and two acyl substituents at unspecified positions.


triacylglycerol 50:0

A triglyceride in which the three acyl groups contain a total of 50 carbons and 0 double bonds.


glycerophosphoinositol phosphate

Any glycerophosphoinositol bearing one or more additional phospho substituents on the inositol ring.


glycerophosphoinositol

Any glycerophospholipid having the polar alcohol inositol esterified to the phosphate group at the sn-3 position of the glycerol backbone.


A plasmalogen of unkown fatty acid composition and where the glycerolipid is not defined, R3 can be H or a phospholipid.


A 1-monoglyceride that has palmitoyl as the acyl group. A natural product found in Neolitsea daibuensis.


lysophosphatidylethanolamine 22:6

An acyl-sn-glycero-3-phosphoethanolamine in which the acyl group contains twenty-two carbons with six double bonds and is attached to the glycero moiety at either position 1 or 2.


2-acylglycerol 18:0

A 2-monoglyceride in which the acyl group contains 18 carbons and is fully saturated.


monoacylglycerol 20:5

A monoglyceride in which the acyl group contains a total of 20 carbon atoms and 5 double bonds at unspecified positions.


phosphatidylethanolamine 40:6

A phosphatidylethanolamine in which the two acyl groups contain a total of 40 carbons and 6 double bonds.


phosphatidylglycerol 32:1

A phosphatidylglycerol in which the two acyl groups contain a total of 32 carbon atoms and 1 double bond.


phosphatidylinositol 36:4

A 1-phosphatidyl-1D-myo-inositol in which the two acyl groups contain a total of 36 carbon atoms and 4 double bonds.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl group at position 1 is unspecified while that at position 2 is specified as stearoyl (octadecanoyl).


2-acylglycerol 20:4

A 2-monoglyceride in which the acyl group contains 20 carbons and 4 double bonds.


phosphatidylinositol (16:0/18:2)

A phosphatidylinositol 34:2 in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 18 carbons and 2 double bonds


A 1-phosphatidyl-D-myo-inositol in which the acyl group at position 1 is specified as palmitoyl (hexadecanoyl) while that at position 2 is unspecified.


A glycerophosphoinositol acylated at O(1) of the glycerol moiety.


monoacylglycerol 18:1

A monoglyceride in which the acyl group contains a total of 18 carbon atoms and 1 double bond.


lysophosphatidylethanolamine 18:1

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 18 carbons and 1 double bond.


A phosphatidylinositol in which the inositol moiety is the 1D-myo isomer and the phosphatidyl group is located at its position 1.


triacylglycerol 60:14

A triglyceride in which the three acyl groups contain a total of 60 carbons and 14 double bonds.


lysophosphatidylethanolamine 22:5

A lysophosphatidylethanolamine in which the acyl group contains 22 carbons and 2 double bonds (position not specified).


A phosphatidylglycerol in which the phosphatidyl moiety has R-configuration and the glycerol moiety has S-configuration.


phosphatidylglycerol

A glycerophosphoglycerol that is glycerol in which the hydrogen of one of the primary hydroxy groups has been replaced by a phosphatidyl group.


phosphatidylethanolamine 40:5

A phosphatidylethanolamine in which the two acyl groups contain a total of 40 carbons and 5 double bonds.


phosphatidylethanolamine 40:7

A phosphatidylethanolamine in which the two acyl groups contain a total of 40 carbons and 7 double bonds.


phosphatidyl-L-serine

A class of aminophospholipids in which a phosphatidyl group is esterified to the hydroxy group of serine.


phosphatidylethanolamine 37:0

A phosphatidylethanolamine in which the two acyl groups contain a total of 37 carbons and no double bonds.


lysophosphatidylethanolamine 20:2

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 20 carbons and 2 double bonds.


A phosphatidylinositol 3-phosphate in which the inositol moiety is the D-myo-isomer.


A 1-phosphatidyl-1D-myo-inositol in which the 1- and 2-acyl groups are hexadecanoyl and icosatetraenoyl respectively.


phosphatidylethanolamine 35:2

A 1,2-diacyl-sn-glycero-3-phosphoethanolamine in which the two acyl groups contain a total of 35 carbons and 2 double bonds.


monoacylglycerol 16:1

A monoglyceride in which the acyl group contains a total of 16 carbon atoms and 1 double bond.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl group at position 1 is unspecified while that at position 2 is specified as linoleoyl


monooleoylglycerol

A monoglyceride in which the acyl group is oleoyl with the position of acylation unspecified.


Glyceryl monooleate

A 1-monoglyceride where the acyl group is oleoyl.


A 1-monoglyceride in which the glycerol moiety has sn stereochemistry.


triacylglycerol 50:6

A triglyceride in which the three acyl groups contain a total of 50 carbons and 6 double bonds.


1-acylglycerol 20:4

A 1-monoglyceride in which the acyl group contains 20 carbons and 4 double bonds.


Dioleoylphosphatidic acid

A phosphatidic acid in which the phosphatidyl acyl groups are both oleoyl.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl substituents at positions 1 and 2 are specified as gamma-linolenoyl and oleoyl respectively.


glycerophosphoglycerophosphoglycerol

A glycerophospholipid composed of two molecules of glycerol phosphate covalently linked to a molecule of glycerol, and in which each of the glycerol phosphate moieties may be esterified to one or two fatty acids.


2-acylglycerol 18:1

A 2-monoglyceride in which the acyl group contains 18 carbons and 1 double bond.


triacylglycerol O-51:2

An alkyldiacylglyceride that has a 51 carbons and 2 double bonds in the alkyl and acyl chains (positions not specified).


A 1-phosphatidyl-D-myo-inositol in which the acyl group at position 1 is specified as stearoyl (octadecanoyl) while that at position 2 is unspecified.


1-acylglycerol 18:0

A 1-monoglyceride in which the acyl group contains 18 carbons and is fully saturated.


lysophosphatidylethanolamine 20:0

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 20 carbons and is fully saturated.


A 1-monoglyceride with tetradecanoyl (myristoyl) as the acyl group.


A glycerol ether having an alkyl substituent at the oxygen at the 1-position and an acyl substituent at the oxygen at the 2-position.


phosphatidylinositol

Any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.


monoacylglycerol 14:0

A monoglyceride in which the acyl contains a total of 14 carbon atoms and 0 double bonds.


monoacylglycerol 18:0

A monoglyceride in which the acyl group contains a total of 18 carbon atoms and 0 double bonds.


triacylglycerol 54:6

A triglyceride in which the three acyl groups contain a total of 54 carbons and 6 double bonds.


A phosphatidic acid (36:2) in which both acyl groups are specified as octadec-9-enoyl.


A lysophosphatidylethanolamine obtained by selective hydrolysis of the 1-acyl substituent of any 1,2-diacyl-sn-glycero-3-phosphoethanolamine.


phosphatidylinositol 34:2

A 1-phosphatidyl-1D-myo-inositol in which the two acyl groups contain a total of 34 carbon atoms and 2 double bonds.


triacylglycerol 60:12

A triglyceride in which the three acyl groups contain a total of 60 carbons and 12 double bonds.


lysophosphatidylethanolamine 22:4

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 22 carbons and 4 double bonds.


lysophosphatidic acid

A member of the class of lysophosphatidic acids obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid. A 'closed' class.


phosphatidylglycerol phosphate

A phosphatidylglycerol in which one of the hydroxy groups of the glycerol moiety has been converted to the corresponding dihydrogen phosphate.


phosphatidylserine 38:3

A 3-sn-phosphatidyl-L-serine in which the two acyl groups contain a total of 38 carbon atoms and 3 double bonds.


A plasmalogen that has no fatty acyl chain at sn-2 and where the glycerolipid is not defined, R3 can be H or a phospholipid.


A 1-acylglycerophosphoinositol in which sn-glycerol, acylated at O(1), is linked through a phospho group at O(3) to O(1) of D-myo-inositol.


triacylglycerol 46:0

A triglyceride in which the three acyl groups contain a total of 46 carbons and 0 double bonds.


phosphoinositide

Any phosphatidylinositol that is phosphorylated at one or more of the hydroxy groups of inositol.


1,3-Dihydroxypropan-2-yl formate

A glyceride in which any one of the R groups (position not specified) is an acyl group while the remaining two R groups can be either H or alkyl groups.


A 1-monoglyceride that has octadecadienoyl (linoleoyl) as the acyl group.


Glyceryl arachidonate

A 1-monoglyceride where the acyl group is arachidonoyl.


triacylglycerol 45:0

A triglyceride in which the three acyl groups contain a total of 45 carbons and 0 double bonds.


A triglyceride in which the acyl groups at positions 1 and 2 are specified as oleoyl while that at position 3 is specified as palmitoyl.


phosphatidylinositol 38:4

A 1-phosphatidyl-1D-myo-inositol in which the two acyl groups contain a total of 38 carbon atoms and 4 double bonds.


1,2-diacyl-sn-glycerol 3-phosphate

An sn-glycerol 3-phosphate compound having unspecified O-acyl groups at the 1- and 2-positions.


triacylglycerol 54:8

A triglyceride in which the three acyl groups contain a total of 54 carbons and 8 double bonds.


lysophosphatidylethanolamine

A glycerophosphoethanolamine resulting from partial hydrolysis of a phosphatidylethanolamine, which removes one of the fatty acid groups. The structure is depicted in the image where R(1) = acyl, R(2) = H or where R(1) = H, R(2) = acyl.


A lysophosphatidylethanolamine 18:1 in which the acyl group is located at position 1.


glycerophospholipid

Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.


lysophosphatidic acids

Any monoacylglycerol phosphate obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid or derivatives therein.


Triglyceride

Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


triacyl-sn-glycerol

Any optically active triglyceride that has R-configuration.


2-acylglycerol 16:1

A 2-monoglyceride in which the acyl group contains 16 carbons and 1 double bond.


2-acylglycerol 18:2

A 2-monoglyceride in which the acyl group contains 18 carbons and 2 double bonds.


lysophosphatidylethanolamine 20:4

An acyl-sn-glycero-3-phosphoethanolamine in which the acyl group contains twenty carbons and four double bonds. If R1 is an acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphoethanolamine. If R1 is a hydrogen and R2 is an acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphoethanolamine.


A monoglyceride in which the acyl substituent is located at position 2.


A chiral alkylglycerol having the alkyl group at the 1-position.


cardiolipin

A phosphatidylglycerol composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol.


triacylglycerol 62:15

A triglyceride in which the three acyl groups contain a total of 62 carbons and 15 double bonds.


An alkylglycerol having the alkyl group located at either the sn-1 or sn-3 position.


2-acylglycerol 16:0

A 2-monoglyceride in which the acyl group contains 16 carbons and is fully saturated.


1-acylglycerol 16:0

A 1-monoglyceride in which the acyl group contains 16 carbons and is fully saturated.


phosphatidic acid 36:2

A phosphatidic acid in which the two acyl groups contain a total of 36 carbons and 2 double bonds.


2-lysophosphatidic acid

Any member of the class of lysophosphatidic acids which has a free hydroxy group at the 2-position of the glycerol moiety.


A glycerophosphoethanolamine having an unspecified O-acyl substituent at the 1-position of the glycerol fragment.


phosphatidylethanolamine 42:5

A phosphatidylethanolamine in which the acyl groups at C-1 and C-2 contain 42 carbons in total with 5 double bonds.


1-acylglycerol 18:1

A 1-monoglyceride in which the acyl group contains 18 carbons and 1 double bond.


A 1-acyl-sn-glycerol 3-phosphate having palmitoyl as the acyl group.


A 1-O-acylglycerophosphoethanolamine having (R)-configuration.


A 3-sn-phosphatidyl-L-serine in which the 1- and 2-acyl groups are octadecanoyl and icosatrienoyl respectively.


diradylglycerol

Any lipid that is glycerol bearing two substituent groups - either acyl, alkyl, or alk-1-enyl - at any two of the three possible positions.


phosphatidylserine 36:2

A 3-sn-phosphatidyl-L-serine in which the two acyl groups contain a total of 36 carbon atoms and 2 double bonds.


monoacyl-sn-glycerol 3-phosphate

An sn-glycero-3-phosphate compound having a single unspecified acyl group at either position 1 or position 2.


phosphatidylserine (18:0/22:5)

A phosphatidylserine 40:5 in which the acyl group at C-1 contains 18 carbons and no double bonds while that at C-2 contains 22 carbons and 5 double bonds.


phosphatidic acid

A derivative of glycerol in which one hydroxy group, commonly but not necessarily primary, is esterified with phosphoric acid and the other two are esterified with fatty acids.


A 1-alkyl-2-acylglycerol having acetyl as the acyl substituent.


lysophosphatidylethanolamine 20:5

A lysophosphatidylethanolamine in which the acyl group (position not specified) contains 20 carbons and 5 double bonds.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl group at position 1 is unspecified while that at position 2 is specified as oleoyl


phosphatidylinositol 3-phosphate

A phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.


A 1-monoglyceride that has alpha-linolenoyl as the acyl group.


Hepatitis Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis virus exposure and injury of the liver parenchyma.


Unresectable Fibrolamellar Carcinoma

A fibrolamellar carcinoma that is not amenable to surgical resection.


Recurrent Adult Hepatocellular Carcinoma

A hepatocellular carcinoma that occurs during adulthood and has recurred after a period of remission.


Locally Advanced Hepatocellular Carcinoma

Hepatocellular carcinoma that has spread to nearby tissues or lymph nodes.


Stage IV Childhood Hepatocellular Carcinoma AJCC v7

Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


BCLC Stage 0 Hepatocellular Carcinoma

Very early hepatocellular carcinoma. Patients are optimal candidates for resection. (HPB (Oxford) 2005; 7(1):35-41)


BCLC Stage D Hepatocellular Carcinoma

End-stage hepatocellular carcinoma.  Patients will receive symptomatic treatment. (HPB (Oxford) 2005; 7(1):35-41)


Metastatic Fibrolamellar Carcinoma

A fibrolamellar carcinoma that has spread from the liver to another anatomic site.


Stage III Hepatocellular Carcinoma AJCC v7

Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVA Hepatocellular Carcinoma AJCC v7

Stage IVA includes: Any T, N1, M0.  N1: Regional lymph node metastasis. M0: No distant metastasis.  (AJCC 7th ed.)


Adult Pleomorphic Hepatocellular Carcinoma

A pleomorphic hepatocellular carcinoma that occurs during adulthood.


Stage IV Hepatocellular Carcinoma AJCC v7


BCLC Stage C Adult Hepatocellular Carcinoma

Advanced hepatocellular carcinoma.  Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41)


Stage IV Hepatocellular Carcinoma AJCC v6

Stage IV includes (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.)


Stage II Hepatocellular Carcinoma AJCC v8

Stage II includes: T2, N0, M0. T2: Solitary tumor larger than 2 cm with vascular invasion, or multiple tumors, none larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIA Hepatocellular Carcinoma AJCC v7

Stage IIIA includes: T3a, N0, M0.  T3a: Multiple tumors more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage I Hepatocellular Carcinoma AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Solitary tumor without vascular invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Colon Carcinoma Metastatic in the Liver

A carcinoma that originates from the colonic wall and has spread to the liver.


Stage III Hepatocellular Carcinoma AJCC v8

Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0). T3: Multiple tumors, at least one of which is larger than 5 cm. T4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Moderately Differentiated Hepatocellular Carcinoma

A hepatocellular carcinoma characterized by the presence of malignant cells with abundant eosinophilic cytoplasm forming trabecular and pseudoglandular patterns.  It is usually associated with tumors that are larger than 3 cm in diameter.


Hepatocellular carcinoma, spindle cell variant

A morphologic variant of hepatocellular carcinoma characterized by the presence of malignant spindle cells or atypical giant cells.


Stage I Childhood Hepatocellular Carcinoma AJCC v6 and v7


BCLC Stage B Hepatocellular Carcinoma

Intermediate hepatocellular carcinoma.  Patients may benefit from chemoembolization. (HPB (Oxford) 2005; 7(1):35-41)


Hepatocellular carcinoma characterized by the presence of diffuse neutrophil infiltrates within the tumor.


Metastatic hepatocellular carcinoma

A hepatocellular carcinoma that has spread to another anatomic site.


Recurrent Childhood Hepatocellular Carcinoma

A hepatocellular carcinoma that occurs during childhood and has recurred after a period of remission.


BCLC Stage B Adult Hepatocellular Carcinoma


Hepatocellular Carcinoma by AJCC v8 Stage

A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to hepatocellular carcinomas and fibrolamellar carcinomas (fibrolamellar variant of hepatocellular carcinoma). Intrahepatic cholangiocarcinomas, combined hepatocellular-cholangiocarcinomas, and sarcomas of the liver are not staged using this staging system. (from AJCC 8th Ed.)


A hepatocellular carcinoma that arises in a patient with a history of organ transplantation.


Hepatitis B Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis B virus exposure and injury of the liver parenchyma.


Hepatitis C Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis C virus exposure and injury of the liver parenchyma.


BCLC Stage 0 Adult Hepatocellular Carcinoma

Very early hepatocellular carcinoma. Patients are optimal candidates for resection. (HPB (Oxford) 2005; 7(1):35-41)


Colorectal Adenocarcinoma Metastatic in the Liver

An adenocarcinoma that originates from the colorectal area and has spread to the liver.


Stage IV Hepatocellular Carcinoma AJCC v8

Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Well Differentiated Hepatocellular Carcinoma

A hepatocellular carcinoma characterized by the presence of malignant cells with mild atypia and an increased nuclear/cytoplasmic ratio forming thin trabecular patterns.  It is usually associated with small tumors and an early stage.


Stage IVA Hepatocellular Carcinoma AJCC v8

Stage IVA includes: Any T, N1, M0. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


BCLC Stage A Adult Hepatocellular Carcinoma

Early hepatocellular carcinoma.  Patients are candidates for radical therapies (resection, liver transplantation, or percutaneous treatments). (HPB (Oxford) 2005; 7(1):35-41)


Stage III Childhood Hepatocellular Carcinoma AJCC v7

Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVB Hepatocellular Carcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Hepatocellular Carcinoma by AJCC v7 Stage

A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 7th edition.


Stage IIIB Hepatocellular Carcinoma AJCC v8

Stage IIIB includes: T4, N0, M0. T4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Localized Unresectable Adult Hepatocellular Carcinoma

A localized hepatocellular carcinoma that occurs during adulthood and it is not amenable to surgical resection.


Adult Fibrolamellar Carcinoma

A hepatocellular carcinoma, fibrolamellar variant that occurs during adulthood.


Poorly Differentiated Hepatocellular Carcinoma

A hepatocellular carcinoma characterized by the presence of malignant pleomorphic cells forming solid patterns.


Recurrent Fibrolamellar Carcinoma

The reemergence of fibrolamellar carcinoma after a period of remission.


A hepatocellular carcinoma that develops following alcohol-induced injury of the liver parenchyma.


Stage IVB Hepatocellular Carcinoma AJCC v7

Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


BCLC Stage C Hepatocellular Carcinoma

Advanced hepatocellular carcinoma.  Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41)


Small Hepatocellular Carcinoma

Hepatocellular carcinoma measuring equal to or less than 2 cm in diameter. It includes early hepatocellular carcinoma and small progressed hepatocellular carcinoma.


Pleomorphic Hepatocellular Carcinoma

A morphologic variant of hepatocellular carcinoma, characterized by the presence of malignant cells which show marked variation in their size and shape. Bizarre mononuclear or multinucleated giant cells are often present.