Any piperazinone that has a piperazine-2,5-dione skeleton.


inorganic peroxide

Compounds of structure ROOR' in which R and R' are inorganic groups.


trans-Stilbene

Any olefinic compound characterised by a 1,2-diphenylethylene backbone.


iminium ion

Cations of structure R2C=N(+)R2.


Stage IVA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

Stage IVA includes: T4, Any N, M0. T4: Uterine corpus endometrial stroma sarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Uterine Corpus High Grade Endometrial Stromal Sarcoma

A rare, high grade sarcoma that arises from the endometrial stroma. It is characterized by round cell morphology. It was previously also known as undifferentiated uterine sarcoma. In 2014, high grade endometrial stromal sarcoma was reclassified and is currently considered a distinct and rare neoplasm. It appears to have a prognosis that falls between low grade endometrial stromal sarcoma and undifferentiated sarcoma.


Cervical Malignant Peripheral Nerve Sheath Tumor

A rare malignant neoplasm with nerve sheath differentiation arising from the cervix.


Stage I Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage I includes: T1, N0, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIIC Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Uterine Corpus Low Grade Endometrial Stromal Sarcoma

A rare, indolent, invasive mesenchymal tumor that arises from the endometrial stroma. It is characterized by the presence of a plexiform vasculature, infrequent mitoses, and insignificant cytologic atypia. Late recurrences may occur.


Stage IIIA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IVB Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Uterine Corpus Endometrial Stromal Sarcoma by AJCC v8 Stage

A term that refers to the staging of uterine corpus endometrial stroma sarcoma according to the American Joint Committee on Cancer, 8th edition.


Cervical Angiosarcoma

A highly aggressive malignant vascular neoplasm that arises from the cervix and shows endothelial cell differentiation.


Stage II Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage II includes: T2, N0, M0. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Endocervical Undifferentiated Sarcoma

A high grade undifferentiated sarcoma that arises from the endocervix.


Stage IV Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus endometrial stroma sarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Malignant Cervical Soft Tissue Neoplasm

A rare malignant mesenchymal neoplasm that arises from the cervix.


AIDS-Related Cervical Kaposi Sarcoma

A Kaposi sarcoma arising from the cervix in patients who are infected with the human immunodeficiency virus.


Stage IA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus, measuring 5 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage III Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Cervical Low Grade Endometrioid Stromal Sarcoma

A very rare sarcoma that arises from the cervix and is characterized by the presence of cells that resemble endometrial stromal cells.


An aldohexose used as a source of energy and metabolic intermediate.


alkane

An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms.


Octadecane

A straight-chain alkane carrying 18 carbon atoms.


long-chain alkane

Any alkane having a chain length of at least 13 carbon atoms.


Duloxetine hydrochloride

A duloxetine hydrochloride in which the duloxetine moiety has S configuration.


The anhydrous form of (S)-ropivacaine hydrochloride.


The (R)-enantiomer of bromazine.


straight-chain fatty acid

Any fatty acid whose skeletal carbon atoms form an unbranched open chain.


hydroxypalmitic acid

A hydroxy fatty acid that is palmitic (hexadecanoic) acid substituted with one hydroxy group.


linolenic acid

A two-membered subclass of octadecatrienoic acid comprising the (9Z,12Z,15Z)- and (6Z,9Z,12Z)-isomers. Linolenic acids are nutrients essential to the formation of prostaglandins and are also used in making paints and synthetic resins.


Vaccenic acid

An octadecenoic acid having a double bond at position 11; and which can occur in cis- or trans- configurations.


octadecadienoic acid

Any straight-chain, C18 polyunsaturated fatty acid having two C=C double bonds.


conjugated linoleic acid

An octadecadienoic acid having a system of two conjugated double bonds at any position.


docosapentaenoic acid

Any straight-chain, C22 fatty acid having five C=C double bonds.


Tetradecenic acid

A tetradecenoic acid having its double bond in the 2-position.


2-Hydroxyhexadecanoic acid

A 2-hydroxy fatty acid comprising a C16 straight chain carrying a hydroxy substituent at position 2.


octadecatrienoic acid

Any trienoic fatty acid having eighteen carbons.


fatty acid 20:3

Any trienoic fatty acid with twenty carbons.


hexadecadienoic acid

Any straight-chain, C16 polyunsaturated fatty acid containing two C=C double bonds (position and geometry not specified).


3-Hydroxyhexadecanoic acid

A long-chain fatty acid that is the 3-hydroxy derivative of palmitic acid.


cis-2-decenoic acid,CDA

A decenoic acid having its double bond in position 2.


butenoic acid

Any C4, straight-chain fatty acid containing one double bond.


The (5Z,7E,9E,14Z,17Z)-isomer of icosapentaenoic acid.


Palmitolinoleic acid

A hexadecenoic acid in which the double bond is located at position 9.


pentenoic acid

Any C5, straight-chain, monounsaturated fatty acid.


tetracosenoic acid

Any C24 monounsaturated fatty acid containing one double bond.


cis-Parinaric acid

The (9Z,11E,13E,15Z)-isomer of parinaric acid.


docosenoic acid

A C22, monounsaturated fatty acid carrying a C=C double bond at any position.


tetradecenoic acid

Any C14 straight-chain monounsaturated fatty acid having one C=C double bond.


hexadecenoic acid

A C16 straight-chain monounsaturated fatty acid having one C=C double bond.


octadecatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of an 18-carbon straight chain.


Eicosa-5,8,11-trienoic acid

An icosatrienoic acid with three bonds at positions 5, 8 and 11.


decenoic acid

Any C10 monounsaturated fatty acid having a double bond in the carbon backbone.


beta-Parinaric acid

The all-trans- isomer of parinaric acid.


But-2-enoic acid

A butenoic acid having the double bond at position C-2.


docosatetraenoic acid

Any straight-chain, C22 fatty acid having four C=C double bonds.


Head and Neck Disorder

A non-neoplastic or neoplastic disorder that affects the anatomic structures of the head and neck region.  This category includes inflammatory disorders, benign neoplasms, precancerous conditions, and malignant neoplasms.


Congenital thyroid disorder

A thyroid gland disorder present at birth. It includes thyroid gland aplasia and thyroid gland hypoplasia, both result in hypothyroidism.


Disorder of neck

A non-neoplastic or neoplastic disorder that affects the anatomic structures of the neck region.  This category includes disorders of the pharynx, larynx, thyroid gland, and parathyroid gland.


Non-Neoplastic Thyroid Gland Disorder

A non-neoplastic disorder that affects the thyroid gland.  Representative examples include hyperthyroidism, hypothyroidism, thyroiditis, and thyroid gland abscess.


Non-Neoplastic Neck Disorder

A non-neoplastic disorder that affects the anatomic structures of the neck region.  This category includes non-neoplastic disorders of the pharynx, larynx, thyroid gland, and parathyroid gland.


Non-Neoplastic Head and Neck Disorder

A non-neoplastic disorder that affects the anatomic structures of the head and neck region.


Tetranabinex

A diverse group of pharmacologically active secondary metabolite characteristic to Cannabis plant as well as produced naturally in the body by humans and animals. Cannabinoids contain oxygen as a part of the heterocyclic ring or in the form of various functional groups. They are subdivided on the basis of their origin.


phytocannabinoid

A class of cannabinoid which are C21 terpenophenolic compounds isolated primarily from Cannabis sativa.


endocannabinoid

A class of cannabinoids present in mammalian biological fluids and tissues that activate cannabinoid receptors.


oxooctadecadienoic acid

An oxo fatty acid that is obtained by oxidation of the allylic hydroxy group of any hydroxyoctadecadienoic acid during its metabolism.


13-Oxooctadeca-9,11-dienoic acid

An oxooctadecadienoic acid that is 9,11-octadecadienoic acid in which the oxo group is located at position 13.


D-Lysine hydrochloride

The hydrochloride salt of D-lysine.


A quinolin-4-one having methyl and hydroxy substituents at the 2- and 3-positions respectively.


Methylsuccinic acid

A dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group.


gamma-lactone

A lactone having a five-membered lactone ring.


butenolide

A gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.


A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one in which all or the hydrogens attached to the benzene ring are replaced by chlorines. A fungicide used for the control of rice blast, it is not approved for use within the European Union.


The 2-chloro derivative of cis-4-carboxymethylenebut-2-en-1,4-olide.


decatromicin A

A carbohydrate-containing antibiotic isolated from Actinomadura sp. MK73-NF4. It specifically inhibits the growth of gram-positive bacteria including multi-drug resistant strains such as Staphylococcus aureus MS9610 and menthicilin-resistant S.aureus (MRSA).


The trans-isomer of 2-chloro-4-carboxymethylenebut-2-en-1,4-olide.


Teniposide

A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.


vitamin C

Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.


Sarmentologenin

A steroid lactone that is card-20(22)-enolide substituted by hydroxy groups at positions 3, 5, 11, 14 and 19.


Any gamma-lactone having the lactone moiety derived from 4-hydroxybutanoic acid.


Triprolidine hydrochloride

A hydrochloride resulting from the formal reaction of equimolar amounts of triprolidine and hydrogen chloride. Its monohydrate is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.


Halogenated cyanine compound that binds nucleic acids.


A C21-steroid that is cortisone in which the 21-hydroxy group has been oxidised to the corresponding aldehyde.


A C21-steroid that is cortisol in which the 21-hydroxy group has been oxidised to the corresponding aldehyde.


Meperidine hydrochloride

The hydrochloride salt of pethidine. An analgesic used for the treatment of postoperative and labour pain.


quercetin O-glucoside

A quercetin O-glycoside that is an O-glucosylated derivative of quercetin.


N-tetracosenoylsphingosine

An acylsphingosine in which the acyl moiety contains 24 carbons and 1 double bond.


diarylmethane

Any compound containing two aryl groups connected by a single C atom.


A diarylmethane in which the two aryl groups are specified as 5-methylfuran-2-yl and pyrrol-3-yl.


Dextromethadone

A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder.


Levomethadone

A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (R)-configuration. It is the active enantiomer of methadone and its hydrochloride salt is used to treat adults who are addicted to drugs such as heroin and morphine.


Symmetrel

A hydrochloride obtained by combining amantadine and hydrochloric acid in equimolar amounts.


bromomethanes

A halomethane that is methane in which one or more hydrogens has been replaced by bromine.


Fluorobenzene

Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group.


Copper(I) chloride

An inorganic chloride of copper in which the metal is in the +1 oxidation state.


CUPRIC CHLORIDE ANHYDROUS

An inorganic chloride of copper in which the metal is in the +2 oxidation state.


Stage IIIB Cervical Cancer AJCC v9

Stage IIIB includes: T3b, N0, M0. T3b: Tumor extending to pelvic wall and/or causing hydronephrosis or nonfunctioning kidney (unless known to be due to another cause). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Refractory Endometrial Mucinous Adenocarcinoma

Endometrial mucinous adenocarcinoma that is resistant to treatment.


Refractory Microsatellite Stable Endometrial Carcinoma

Microsatellite stable endometrial carcinoma that is resistant to treatment.


Refractory Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma that is resistant to treatment.


Metastatic Endometrial Mixed Cell Adenocarcinoma

Endometrial mixed cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


Stage I Cervical Cancer FIGO 2009

The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2009)


Cervical Mucoepidermoid Carcinoma

A rare carcinoma that arises from the cervix. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Pure Cutaneous Mastocytosis

Mastocytosis that manifests with pure cutaneous involvement.


Stage IIB Cervical Cancer FIGO 2018

Cervical carcinoma with parametrial involvement but not up to the pelvic wall. (FIGO 2018)


Stage IIB Cervical Cancer FIGO 2009

Cervical carcinoma with parametrial invasion. (FIGO 2009)


Cervical Invasive Stratified Mucinous Adenocarcinoma

A rare, distinct form of invasive cervical mucinous adenocarcinoma associated with human papillomavirus infection. It is characterized by the presence of stratiﬁed, immature epithelial cells containing varying quantities of intracytoplasmic mucin.


Undifferentiated schizophrenia

A subtype of schizophrenia in which the individual exhibits the characteristic symptoms of schizophrenia but the overall picture is not one of catatonic type, paranoid type, or disorganized type schizophrenia.


Stage I Cervical Cancer AJCC v9

Stage I includes: T1, N0, M0. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Cervical carcinoma stage II AJCC v7

Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0); IIB (T2b, N0, M0); T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


High Grade Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


Human Papillomavirus-Related Cervical Squamous Cell Carcinoma

A cervical squamous cell carcinoma associated with human papillomavirus infection.


Stage III Cervical Cancer FIGO 2018

Cervical carcinoma that involves the lower third of the vagina and/or extends to the pelvic wall and/or causes hydronephrosis or nonfunctioning kidney and/or involves pelvic and/or para-aortic lymph nodes. (FIGO 2018)


Stage IB2 Cervical Cancer FIGO 2018

Invasive cervical carcinoma equal or more than 2 cm and less than 4 cm in greatest dimension. (FIGO 2018)


Stage IVA Cervical Cancer FIGO 2018

The cervical carcinoma has spread to adjacent pelvic organs. (FIGO 2018)


Metastatic Endometrial Clear Cell Adenocarcinoma

Endometrial clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


Human Papillomavirus-Related Cervical Adenocarcinoma In Situ

Cervical adenocarcinoma in situ associated with human papillomavirus infection.


Stage IIIC2 Cervical Cancer FIGO 2018

Cervical carcinoma with para-aortic lymph node metastasis. (FIGO 2018)


Malignant hepatobiliary neoplasms

A malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder.  Representative examples include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Stage III Cervical Cancer AJCC v6 and v7

Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T1, N1, M0), (T2, N1, M0), (T3a, N1, M0), (T3b, Any N, M0). T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non functioning kidney.  N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


undifferentiated carcinoma of cervix

A rare carcinoma that arises from the cervix and is characterized by the lack of specific cellular differentiation.


Stage IV Cervical Cancer AJCC v8

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


Endometrial Mucinous Adenocarcinoma, Intestinal-Type

A rare mucinous adenocarcinoma arising from intestinal metaplasia of the endometrium.


Stage II Cervical Cancer AJCC v8

Stage II includes: T2, Any N, M0. T2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IA Cervical Cancer AJCC v8

Stage IA includes: T1a, Any N, M0. T1a: Tumor diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. M0: No distant metastasis. (AJCC 8th Ed.)


Mitochondrial enzyme deficiency

A constellation of disorders whose common thread is the insufficient quantity of one or more mitochondrial enzymes.


Stage IIIC1 Cervical Cancer AJCC v9

Stage IIIC1 includes: TX, T0, T1-3, N1, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IIA Cervical Cancer AJCC v7

Stage IIA includes: IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0).  T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage IB Cervical Cancer AJCC v8

Stage IB includes: T1b, Any N, M0. T1b: Tumor with clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. It includes all macroscopically visible lesions, even those with superficial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Cervical Cancer by FIGO Stage 2009

A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2009.


Non-Neoplastic Central Nervous System Disorder


Stage IB2 Cervical Cancer AJCC v8

Stage IB2 includes: T1b2, Any N, M0. T1b2: Tumor with clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Cervical Cancer AJCC v6

Tumor without parametrial invasion.


Metastatic Malignant Neoplasm to the Cervix

A malignant neoplasm that has spread to the cervix from another anatomic site.


Stage IB1 Cervical Cancer FIGO 2018

Invasive cervical carcinoma with equal or more than 5 mm depth of stromal invasion, and less than 2 cm in greatest dimension. (FIGO 2018)


Recurrent Endometrial Squamous Cell Carcinoma

The reemergence of endometrial squamous cell carcinoma after a period of remission.


POLE-Ultramutated Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by mutations in the exonuclease domain of the DNA polymerase epsilon (POLE) gene that result in an ultra-mutated tumor phenotype.


Cervical Adenocarcinoma In Situ

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Non-Neoplastic Retroperitoneal Disorder

A non-neoplastic disorder that affects the retroperitoneum.


Cystic fibrosis pulmonary exacerbation

An acute episode of worsening pulmonary symptoms related to cystic fibrosis.


Non-Neoplastic Genitourinary System Disorder

A non-neoplastic disorder that affects the genitourinary system.


Stage IIIA Cervical Cancer FIGO 2009

Cervical carcinoma involving lower one-third of the vagina. (FIGO 2009)


Rare Non-Neoplastic Disorder

A non-neoplastic disorder that is rare.


Stage IA1 Cervical Cancer AJCC v8

Stage IA1 includes: T1a1, Any N, M0. T1a1: Invasive cervical carcinoma with measured stromal invasion of 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. M0: No distant metastasis. (AJCC 8th Ed.)


Human Papillomavirus-Independent Cervical Squamous Cell Carcinoma

A cervical squamous cell carcinoma not associated with human papillomavirus infection.


p53-Mutant Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by the presence of p53 gene mutations.


Non-Neoplastic Endocrine Disorder

A non-neoplastic disorder that affects the endocrine system.  Representative examples include diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency.


Metastatic Microsatellite Stable Endometrial Carcinoma

Microsatellite stable endometrial carcinoma that has spread from its original site of growth to another anatomic site.


Non-Neoplastic Vascular Disorder

A term that includes all non-neoplastic vascular disorders.


Early Rheumatoid Arthritis

Recent diagnosis of rheumatoid arthritis (usually within one to two years of onset) during which treatment may be more effective and possibly improve the disease course.


B-Cell Lymphoproliferative Disorder

A non-neoplastic or neoplastic proliferation of B-lymphocytes.


Stage II Cervical Cancer FIGO 2009

Cervical carcinoma invading beyond the uterus but not extending onto the lower third of the vagina or to the pelvic wall. (FIGO 2009)


Microsatellite Stable Endometrial Carcinoma

Endometrial carcinoma characterized by the absence of microsatellite instability.


Abnormal Laboratory Test Result

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

A laboratory test result that falls outside of the normal, acceptable range.


Enzyme Deficiency

A finding in which there is a subnormal amount of an enzyme. Enzymes are proteins that are necessary in certain catabolic processes.


Stage IV Cervical Cancer FIGO 2009

Cervical carcinoma involving adjacent and distant organs. (FIGO 2009)


Non-Neoplastic Peritoneal and Retroperitoneal Disorder

A non-neoplastic disorder that affects the peritoneum and/or retroperitoneum.


Stage IB Cervical Cancer FIGO 2009

Cervical carcinoma measuring more than 5 mm in depth. (FIGO 2009)


Recurrent Endometrial Mixed Cell Adenocarcinoma

The reemergence of endometrial mixed cell adenocarcinoma after a period of remission.


Refractory Endometrial Adenocarcinoma

Endometrial adenocarcinoma that is resistant to treatment.


Non-Neoplastic Soft Tissue Disorder

A non-neoplastic disorder that affects the soft tissue.


Locally Advanced Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Recurrent Endometrial Mucinous Adenocarcinoma

The reemergence of endometrial mucinous adenocarcinoma after a period of remission.


Stage III Cervical Cancer FIGO 2009

Cervical carcinoma involving lower vagina, pelvic sidewall, and ureters. (FIGO 2009)


Stage IB2 Cervical Cancer AJCC v9

Stage IB2 includes: T1b2, N0, M0. T1b2: Tumor measuring more than 2 cm and equal or less than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IIIA Cervical Cancer AJCC v9

Stage IIIA includes: T3a, N0, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IA1 Cervical Cancer FIGO 2009

Cervical carcinoma measuring equal or less than 3 mm in depth. (FIGO 2009)


Stage IB Cervical Cancer FIGO 2018

Invasive cervical carcinoma with measured deepest invasion equal or more than 5 mm (greater than Stage IA), lesion limited to the cervix uteri. (FIGO 2018)


Polyarticular Still Disease

Juvenile rheumatoid arthritis affecting multiple joints, usually symmetrically. It may be associated with low grade fever, anemia, and weight loss. Patients usually test negative for rheumatoid factor.


Stage IIA2 Cervical Cancer AJCC v7

Stage IIA2 includes: T2a2, N0, M0.  Tumor invades beyond uterus but no to pelvic wall or to lower third of vagina. No parametrial invasion.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Endometrial Large Cell Neuroendocrine Carcinoma

A high grade neuroendocrine carcinoma that arises from the endometrium. It is composed of large polygonal cells arranged in well-demarcated nests, trabeculae or cords with peripheral palisading.


Cervical Squamous Cell Carcinoma In Situ

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Nerve palsy

Paralysis that is caused by damage to a nerve.


Stage IV Cervical Cancer AJCC v9

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. M1: Distant metastasis including inguinal lymph nodes, lung, liver, bone, or intraperitoneal metastases. Metastases to pelvic or paraaortic lymph nodes, or vagina are excluded. (from AJCC 9th Ed.)


Human Papillomavirus-Independent Cervical Adenocarcinoma

Cervical adenocarcinoma not associated with human papillomavirus infection.


Stage IA Cervical Cancer AJCC v9

Stage IA includes: T1a, N0, M0. T1a: Tumor that can be diagnosed only by microscopy with maximum depth of invasion equal or less than 5 mm. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IIA2 Cervical Cancer AJCC v9

Stage IIA2 includes: T2a2, N0, M0. T2a2: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Respiratory, thoracic and mediastinal disorders

A non-neoplastic or neoplastic disorder that affects the respiratory system or the thoracic organs.


Stage IIA1 Cervical Cancer AJCC v7

Stage IIA1 includes: T2a1, N0, M0.  Tumor invades beyond uterus but no to pelvic wall or to lower third of vagina. No parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Cerebral Adrenoleukodystrophy

A subtype of adrenoleukodystrophy (ALD) occurring in approximately 40 percent of boys with ALD, primarily affecting the cerebrum, resulting in rapidly declining neurocognitive function and in most patients, premature death.


Congenital Systemic Disorder

An inherited disorder that presents with systemic manifestations.


Refractory Cervical Squamous Cell Carcinoma, Not Otherwise Specified

Cervical squamous cell carcinoma, not otherwise specified, that is resistant to treatment.


Congenital Adrenal Gland Disorder

A genetic disorder that affects the adrenal gland.  It includes adrenal gland hyperplasia and adrenal gland hypoplasia.


Schizophrenia, Childhood

Schizophrenia occurring in childhood.


Retroperitoneal disorder

A non-neoplastic or neoplastic disorder that affects the retroperitoneum.


Schizophrenia, Disorganized

A subtype of schizophrenia characterized by disorganized speech, disorganized behavior, and a flat or inappropriate affect; associated features include grimacing, mannerisms, and other oddities of behavior. Criteria for the catatonic type of schizophrenia are not met.


Cervical Adenocarcinoma, Not Otherwise Specified

A cervical adenocarcinoma that cannot be classified by WHO criteria or International Endocervical Adenocarcinoma Criteria and Classification (IECC).


Thoracic Diseases

A non-neoplastic or neoplastic disorder that affects the thorax and/or the organs of the thoracic cavity.  Representative examples include pleural infection, mediastinitis, thymoma, mediastinal lymphoma, and pleural mesothelioma.


Infiltrating Cervical Carcinoma

A carcinoma that arises from the cervix and invades into the stromal tissue.


Stage IB3 Cervical Cancer AJCC v9

Stage IB3 includes: T1b3, N0, M0. T1b3: Tumor measuring more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Metastatic Endometrial Serous Adenocarcinoma

An endometrial serous adenocarcinoma that has spread to other anatomic sites.


Male Reproductive System Carcinoma

A malignant neoplasm that arises from the epithelium of any part of the male reproductive system. Representative examples include prostate carcinoma and penile carcinoma.


Stage III Cervical Cancer AJCC v8

Stage III includes: T3, Any N, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIIC2 Cervical Cancer AJCC v9

Stage IIIC2 includes: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 9th Ed.)


Human Papillomavirus-Related Cervical Adenocarcinoma

A cervical adenocarcinoma associated with the presence of human papillomavirus infection.


Stage IB1 Cervical Cancer AJCC v9

Stage IB1 includes: T1b1, N0, M0. T1b1: Tumor measuring more than 5 mm in depth and equal or less than 2 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Abnormal Blood Chemistry and Hematology Test Result

A laboratory test result that indicates the presence of abnormal blood chemistry and/or hematology values.


Rare Diseases

A disease that affects fewer than 200,000 people in the United States.


Stage IIB Cervical Cancer AJCC v9

Stage IIB includes: T2b, N0, M0. T2b: Tumor with parametrial invasion but not up to the pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage II Cervical Cancer AJCC v6

Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIB (T2b, N0, M0). T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion. T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Type I Endometrial Adenocarcinoma

A classification of primary endometrial adenocarcinomas that refers to endometrioid adenocarcinoma and mucinous adenocarcinoma.


Peritoneal and retroperitoneal disorders

A non-neoplastic or neoplastic disorder that affects the peritoneum and/or retroperitoneum.


Stage IIB Cervical Cancer AJCC v8

Stage IIB includes: T2b, Any N, M0. T2b: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina with parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Non-Neoplastic Digestive System Disorder

A non-neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. Representative examples include infections, ulcers, cirrhosis, and diverticulosis.


Stage IIIA Cervical Cancer AJCC v6 and v7

Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Recurrent Malignant Endocervical Neoplasm

The reemergence of a malignant neoplasm of the endocervix after a period of remission.


Recurrent Cervical Squamous Cell Carcinoma

The reemergence of cervical squamous cell carcinoma after a period of remission.


Cervical Yolk Sac Tumor

A yolk sac tumor that arises from the cervix. Patients present with abnormal vaginal bleeding and a polypoid, friable mass, protruding into the vagina.


Mental disorder in childhood

A category of psychiatric disorders which includes disorders most commonly identified in infancy, childhood, or adolescence.


FIGO Grade 2 Endometrial Mucinous Adenocarcinoma

A primary mucinous adenocarcinoma of the endometrium that contains 6-50% non-squamous solid areas.


Endometrial Mucinous Adenocarcinoma, Gastric-Type

A rare mucinous adenocarcinoma arising from gastric metaplasia of the endometrium.


Stage IB1 Cervical Cancer FIGO 2009

Cervical carcinoma measuring more than 5 mm in depth and equal or less than 4 cm in maximum diameter. (FIGO 2009)


Stage IVB Cervical Cancer AJCC v9

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis including inguinal lymph nodes, lung, liver, bone, or intraperitoneal metastases. Metastases to pelvic or paraaortic lymph nodes, or vagina are excluded. (from AJCC 9th Ed.)


Unresectable Cervical Adenocarcinoma

Cervical adenocarcinoma that is not amenable to surgical resection.


Recurrent Endometrial Endometrioid Adenocarcinoma

The reemergence of endometrial endometrioid adenocarcinoma after a period of remission.


Stage IB1 Cervical Cancer

Stage IB1 includes: T1b1, N0, M0.  T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Cervical Cancer by AJCC v8 Stage

A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 8th edition.


Stage IIIC Cervical Cancer AJCC v9

Stage IIIC includes: IIIC1: TX, T0, T1-3, N1, M0; IIIC2: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes.  M0: No distant metastasis. (from AJCC 9th Ed.)


Locally Advanced Cervical Carcinoma

A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IIB Cervical Cancer AJCC v6 and v7

Stage IIB includes: T2b, N0, M0.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IIA2 Cervical Cancer FIGO 2009

Cervical carcinoma limited to the upper two-thirds of the vagina and measuring more than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Brain Disorder

A non-neoplastic disorder that affects the brain. Representative examples include cerebrovascular disorder, hydrocephalus, and encephalitis.


Refractory Endometrial Serous Adenocarcinoma

Endometrial serous adenocarcinoma that is resistant to treatment.


Recurrent Endometrial Dedifferentiated Carcinoma

The reemergence of endometrial dedifferentiated carcinoma after a period of remission.


Recurrent Endometrial Cancer

The reemergence of endometrial carcinoma after a period of remission.


Metastatic Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma that has spread to another anatomic site.


Prostatic Basal Cell Hyperplasia

A type of prostatic hyperplasia.  It is characterized by the presence of nodules of dark basal cells around residual prostatic secretory cells.


Stage IA1 Cervical Cancer AJCC v9

Stage IA1 includes: T1a1, N0, M0. T1a1: Tumor with measured stromal invasion equal or less than 3 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Connective and Soft Tissue Disorder

A non-neoplastic or neoplastic disorder that affects the connective and soft tissue.


Utricle-Associated Mucosal Gland Hyperplasia

A benign microacinar proliferation occurring exclusively in the area of the utricle.


Biliary System Disorder

A non-neoplastic or neoplastic disorder that affects the intrahepatic or extrahepatic bile ducts or the gallbladder. Representative examples of non-neoplastic disorders include cholangitis and cholecystitis. Representative examples of neoplastic disorders include extrahepatic bile duct adenoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Unresectable Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma that is not amenable to surgical resection.


Prostatic Clear Cell Cribriform Hyperplasia

A rare type of prostatic hyperplasia. It is characterized by hyperplastic glandular cells with clear cytoplasm.


Recurrent Endometrial Clear Cell Adenocarcinoma

The reemergence of endometrial clear cell adenocarcinoma after a period of remission.


CTRP Clinical Finding

A finding concept that has been requested by CTRP to be used in the disease field for abstraction and search of clinical trials.


AIDS-Related Malignant Cervical Neoplasm

A malignant neoplasm that arises from the cervix in a patient with acquired immunodeficiency syndrome. This category includes cervical carcinoma, Kaposi sarcoma, and non-Hodgkin lymphoma.


Stage IIA2 Cervical Cancer AJCC v8

Stage IIA2 includes: T2a2, Any N, M0. T2a2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Stage I Cervical Cancer AJCC v8

Stage I includes: T1, Any N, M0. T1: Tumor confined to uterus (extension to corpus should be disregarded). M0: No distant metastasis. (AJCC 8th Ed.)


No Specific Molecular Profile Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by the absence of POLE gene mutations, mismatch repair (MMR) deficiency, and p53 gene mutations.


Metastatic Endometrial Carcinoma

A carcinoma that arises from the endometrium and has metastasized to another anatomic site.


Refractory Endometrial Transitional Cell Carcinoma

Endometrial transitional cell carcinoma that is resistant to treatment.


Stage IIIC Cervical Cancer FIGO 2018

Cervical carcinoma with involvement of pelvic and/or para-aortic lymph nodes, irrespective of tumor size and extent (with r and p notations). (FIGO 2018)


Stage II Cervical Cancer FIGO 2018

The cervical carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall. (FIGO 2018)


Non-Neoplastic Pancreatic Disorder

A non-neoplastic disorder that affects the pancreas. Representative examples include pancreatitis and pancreatic insufficiency.


Refractory Endometrial Squamous Cell Carcinoma


Sign or Symptom

Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom).


Paraphrenia

A form of schizophrenia characterized by delusions (of persecution or grandeur or jealousy); symptoms may include anger and anxiety and aloofness and doubts about gender identity; unlike other types of schizophrenia the patients are usually presentable and (if delusions are not acted on) may function in an apparently normal manner.


21-hydroxylase deficiency - simple virilizing

A classic form of congenital adrenal hyperplasia that is characterized by severe 21-hydroxylase deficiency, resulting in glucocorticoid and mineralocorticoid deficiency, but without clinically significant salt wasting, and with androgen excess, which causes virilization in female infants.


Recurrent Cervical Adenocarcinoma

The reemergence of cervical adenocarcinoma after a period of remission.


Stage IIIB Cervical Cancer FIGO 2009

Cervical carcinoma involving the pelvic sidewall. (FIGO 2009)


Non-Neoplastic Eye Disorder

A non-neoplastic disorder that affects the eye.


Blood and lymphatic system disorders

Any deviation from the normal structure or function of the blood or lymphatic system that is manifested by a characteristic set of symptoms and signs.


Metastatic Cervical Carcinoma

A carcinoma of the cervix that has spread to another anatomic site.


Non-Neoplastic Bone Disorder

A non-neoplastic disorder that affects the bone or articular cartilage.


Non-Neoplastic Endocrine Pancreas Disorder

A non-neoplastic disorder that affects the endocrine pancreas.


Non-Neoplastic Disorder by Special Category


Hereditary Malignant Neoplasm

Malignant neoplasms occurring in families at a rate greater than that expected by chance and caused by germline mutations in a specific gene.


Monogenic Hyperinsulinism

A genetically heterogenous group of hyperinsulinemic conditions caused by mutation(s) in one of the many genes involved in the regulation of insulin secretion.


Cervix carcinoma recurrent

The reemergence of cervical carcinoma after a period of remission.


Endometrial Endometrioid Adenocarcinoma with Clear Cell Change

A morphologic variant of endometrioid adenocarcinoma characterized by the presence of large multinucleated clear cells.


Neuroendocrine cervical carcinoma

A malignant, high grade neuroendocrine neoplasm that arises from the cervix. This category includes small cell and large cell neuroendocrine carcinoma.


Genitourinary System Neoplasm

A benign or malignant neoplasm that affects the genitourinary system.


Stage IB Cervical Cancer AJCC v6 and v7

Stage IB includes: IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Metastatic Cervical Adenocarcinoma

A cervical adenocarcinoma that has spread to another anatomic site.


Gastrointestinal disorder congenital

An abnormality of the digestive system that is present at birth or detected in the neonatal period.


Refractory Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma that is resistant to treatment.


Other Finding

An additional finding not previously noted.


Stage IVA Cervical Cancer AJCC v8

Stage IVA includes: T4, Any N, M0. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


Human Papillomavirus-Independent Cervical Adenocarcinoma In Situ

Cervical adenocarcinoma in situ not associated with human papillomavirus infection.


Endometrioid adenocarcinoma, ciliated cell variant

An endometrioid adenocarcinoma arising from the endometrium, in which ciliated cells line the majority of the malignant glands.


Cervical Cancer by AJCC v7 Stage

A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 7th edition.


Stage IIA1 Cervical Cancer AJCC v9

Stage IIA1 includes: T2a1, N0, M0. T2a1: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IV Cervical Cancer AJCC v6 and v7

Stage IV includes: IVA: (T4, Any N, M0); IVB (Any T, Any N, MI). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M1: Distant metastasis. (AJCC 6th and 7th eds.)


Endometrial Neuroendocrine Carcinoma

A small cell or large cell neuroendocrine carcinoma arising from the endometrium.


Refractory Endometrial Clear Cell Adenocarcinoma

Endometrial clear cell adenocarcinoma that is resistant to treatment.


FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


Stage IA2 Cervical Cancer AJCC v9

Stage IA2 includes: T1a2, N0, M0. T1a2: Tumor with measured stromal invasion of more than 3.0 mm and equal or less than 5.0 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Mental and Behavioral Signs and Symptoms

Clinical evidence of disease resulting from mental and/or behavioral dysfunction.


Stage II Cervical Cancer AJCC v9

Stage II includes: T2, N0, M0. T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IIA Cervical Cancer AJCC v9

Stage IIA includes: T2a, N0, M0. T2a: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IVA Cervical Cancer AJCC v6 and v7

Stage IVA includes: T4, Any N, M0). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (AJCC 6th and 7th eds.)


Immune System and Related Disorders

A group of non-neoplastic and neoplastic disorders resulting from the deregulation and/or deficiency of immune system functions. It includes autoimmune disorders (e.g., lupus erythematosus, dermatomyositis, rheumatoid arthritis), congenital and acquired immunodeficiency syndromes including the acquired immune deficiency syndrome (AIDS), and neoplasms (e.g., lymphomas and malignancies secondary to transplantation).


Cervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma

A carcinoma that arises from the cervix and is characterized by the presence of a cervical adenocarcinoma variant and a neuroendocrine carcinoma component.


Stage IIA Cervical Cancer FIGO 2009

Cervical carcinoma limited to the upper two-thirds of the vagina. (FIGO 2009)


Non-Neoplastic Disorder

Any disorder other than abnormal tissue growth resulting from uncontrolled cell proliferation.


Stage IA2 Cervical Cancer AJCC v8

Stage IA2 includes: T1a2, Any N, M0. T1a2: Invasive cervical carcinoma with measured stromal invasion of more than 3.0 mm and not more than 5.0 mm, with a horizontal spread of 7.0 mm or less. M0: No distant metastasis. (AJCC 8th Ed.)


Metastatic Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma that has spread to other anatomic sites.


Genitourinary Cancer

A primary or metastatic malignant neoplasm that affects the genitourinary system.


Serous Endometrial Intraepithelial Carcinoma

A precursor of endometrial serous adenocarcinoma characterized by the replacement of the normal endometrial cells by malignant glandular cells that resemble the malignant cells of invasive serous adenocarcinoma. The endometrial neoplastic process is non-invasive. It may coexist with invasive endometrial adenocarcinoma or can be associated with metastases outside the uterus, in the absence of invasive endometrial carcinoma.


Recurrent Endocervical Adenocarcinoma, Usual-Type

The reemergence of endocervical adenocarcinoma, usual-type after a period of remission.


Non-Neoplastic Cardiovascular Disorder

A non-neoplastic disorder that affects the heart and/or vessels.  Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema.


Endometrial Dedifferentiated Carcinoma

A carcinoma that arises from the endometrium and is characterized by the presence of an undifferentiated carcinomatous component and a second component of either FIGO grade 1 or 2 endometrioid carcinoma.


Stage IA2 Cervical Cancer FIGO 2009

Cervical carcinoma measuring more than 3 mm and not more than 5 mm in depth. (FIGO 2009)


Sickle Cell-SS Disease

A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles.


Refractory Cervical Carcinoma

Cervical carcinoma that is resistant to treatment.


Human Papillomavirus-Related Cervical Carcinoma

A carcinoma that arises from the cervix and is caused by human papillomavirus infection.


Endometrial Endometrioid Adenocarcinoma with a Poorly Differentiated Carcinomatous Component

A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with poorly differentiated carcinoma cells.


Stage IIIB Cervical Cancer AJCC v6 and v7

Stage IIIB includes: (T3b, Any N, M0); (T1-3, N1, M0).  T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Disorder of soft tissue

A non-neoplastic or neoplastic disorder that affects the soft tissue.


Female Non-Neoplastic Reproductive System Disorder

A non-neoplastic disorder that affects the female reproductive system. Representative examples include endometriosis, pelvic inflammatory disease, and endometritis.


Non-Neoplastic Connective and Soft Tissue Disorder

A non-neoplastic disorder that affects the connective and soft tissue.


Neoplasm by Morphology

A classification system grouping neoplasms according to their cellular characteristics.


Cervical Cancer by FIGO Stage 2018

A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2018.


Repeat Expansion Disease

A class of genetic diseases that occur when microsatellite repeats expand beyond a threshold length.


Verumontanum Mucosal Gland Hyperplasia

A benign microacinar proliferation occurring exclusively in the verumontanum and adjacent posterior urethra where the ejaculatory ducts and utricle empty into the urethra. Crystalloids and intraluminal mucin are usually absent, but; intraluminal corpora amylacea are often present. The lining epithelium typically consists of bland cuboidal to columnar luminal cells with underlying basal cells.


Unresectable Endometrial Carcinoma

Endometrial carcinoma that is not amenable to surgical resection.


Neoplasm by Special Category

A neoplasm defined by its unique characteristic as they apply to clinical presentation and course, morphologic patterns, frequency, and/or age distribution.


Stage IB Cervical Cancer AJCC v9

Stage IB includes: T1b, N0, M0. T1b: Tumor with measured deepest invasion more than 5 mm (greater than FIGO stage IA); lesion limited to the cervix uteri with size measured by maximum tumor diameter. Note: The involvement of vascular/lymphatic spaces should not change the staging. The lateral extent of the lesion is no longer considered. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IVB Cervical Cancer AJCC v6 and v7

Stage IVB includes: Any T, Any N, MI. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Metastatic Carcinoma to the Uterine Cervix

A carcinoma that has spread to the cervix from another anatomic site.


Low Grade Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Stage IIIA Cervical Cancer FIGO 2018

Cervical carcinoma that involves the lower third of the vagina, with no extension to the pelvic wall. (FIGO 2018)


Non-Neoplastic Musculoskeletal Disorder

A non-neoplastic disorder that affects muscles and bones.


Adenocarcinoma endometrial metastatic

An adenocarcinoma which originated in the endometrium and has spread to another anatomic site.


An exceedingly rare adenocarcinoma that arises from the endometrium and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


FIGO Grade 1 Endometrial Mucinous Adenocarcinoma

A primary mucinous adenocarcinoma of the endometrium that contains equal to or less than 5% non-squamous solid areas.


Stage IB3 Cervical Cancer FIGO 2018

Invasive cervical carcinoma equal or more than 4 cm in greatest dimension. (FIGO 2018)


Stage IA Cervical Cancer FIGO 2009

Cervical carcinoma measuring equal or less than 5 mm in depth and equal or less than 7 mm in width. (FIGO 2009)


AIDS-Related Cervical Carcinoma

A carcinoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


Cutaneous Hematopoietic and Lymphoid Cell Neoplasm

A myeloid or lymphoid cell neoplasm involving the skin.


Cervix Intraepithelial Neoplasia Grade 3 AJCC v7

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Locally Advanced Cervical Adenocarcinoma

A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Schizophrenia and other psychotic disorders

A category of psychiatric disorders characterized by the presence of psychotic symptoms such as delusions or hallucinations or negative symptoms such as affective flattening.


Stage IIIC1 Cervical Cancer FIGO 2018

Cervical carcinoma with pelvic lymph node metastasis only. (FIGO 2018)


Stage IVA Cervical Cancer AJCC v9

Stage IVA includes: T4, Any N, M0. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. (from AJCC 9th Ed.)


Recurrent Endometrial Transitional Cell Carcinoma

The reemergence of endometrial transitional cell carcinoma after a period of remission.


Endometrial Endometrioid Adenocarcinoma with an Undifferentiated Carcinomatous Component

A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with undifferentiated malignant cells.


Stage IB2 Cervical Cancer

Stage IB2 includes: T1b2, N0, M0.  T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Pancreatobiliary Carcinoma

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater.


Refractory Endometrial Carcinoma

Endometrial carcinoma that is resistant to treatment


Disorder by Site

A term that refers to the classification of a disorder according to the anatomic site that is involved in the pathologic process.


Stage III Cervical Cancer AJCC v9

Stage III includes: T3, N0, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage I Cervical Cancer FIGO 2018

The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2018)


Deformity

An anatomic abnormality that is either present at birth or appears later in life.


FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


Clinical Test Result

The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition.


Stage IVB Cervical Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


Stage IIA1 Cervical Cancer FIGO 2018

Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, less than 4 cm in greatest dimension. (FIGO 2018)


Genitourinary System Carcinoma

A carcinoma arising from the genitourinary system. Representative examples include kidney carcinoma, bladder carcinoma, prostate carcinoma, endometrial carcinoma, cervical carcinoma, and ovarian carcinoma.


Stage I Cervical Cancer AJCC v6 and v7

Stage I includes: I (T1, N0, M0); IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0); IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1: Cervical carcinoma confined to uterus (extension to corpus should be disregarded). T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread.  T1a2: Measured stromal invasion more than 3.0mm and not more than 5.0 mm with a horizontal spread 7.0mm or less. T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Cervical Cancer by AJCC v9 Stage

A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 9th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to sarcomas, lymphomas, and melanomas. Sarcomas are staged according to the corpus uteri classification for sarcomas. Lymphomas are staged according to Hodgkin and non-Hodgkin lymphoma classification. Melanomas are not staged. (from AJCC 9th Ed.)


Stage IIA1 Cervical Cancer AJCC v8

Stage IIA1 includes: T2a1, Any N, M0. T2a1: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Non-Neoplastic Hematologic and Lymphocytic Disorder

A disorder that arises from the bone marrow or lymphoid system and is characterized by the absence of a clonal cellular component. It rarely progresses to a malignant neoplasm.


Stage IVB Cervical Cancer FIGO 2018

The cervical carcinoma has spread to distant organs. (FIGO 2018)


Cervical Papillary Squamous Cell Carcinoma

A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures covered with epithelial cells which show features of cervical intraepithelial neoplasia. The malignant cellular component below the papillary structures is a squamous cell carcinoma.


Refractory Cervical Adenocarcinoma

Cervical adenocarcinoma that is resistant to treatment.


Salt-Wasting 21-Hydroxylase Deficiency

A classic form of congenital adrenal hyperplasia characterized by complete absence of 21-hydroxylase activity resulting in deficiency of glucocorticoids and mineralocorticoids accompanied by androgen excess causing virilization in female infants. Mineralocorticoid deficiency results in renal salt-wasting, and if untreated, hyponatremia, hyperkalemia, and shock.


Adenocarcinoma endometrial recurrent

The reemergence of endometrioid adenocarcinoma after a period of remission.


Recurrent Endometrial Serous Adenocarcinoma

The reemergence of endometrial serous adenocarcinoma after a period of remission.


Stage IVB Cervical Cancer FIGO 2009

Cervical carcinoma involving distal organs outside the pelvis. (FIGO 2009)


Stage IV Cervical Cancer FIGO 2018

The cervical carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. (A bullous edema, as such, does not permit a case to be allotted to Stage IV). (FIGO 2018)


Seropositive rheumatoid arthritis

Rheumatoid arthritis in which a patient's serum is positive for certain disease-related antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is more specific than RF which can be found in other pathologic conditions. The production of these disease-associated antibodies may precede the development of clinical symptoms by several years. Seropositive patients have a greater likelihood of developing extra-articular complications and a more severe course of disease.


Type II Endometrial Adenocarcinoma

A classification of primary endometrial adenocarcinomas that refers to clear cell adenocarcinoma, serous adenocarcinoma, and serous endometrial intraepithelial carcinoma.


Finding

Clinical, laboratory or molecular evidence, or absence of evidence of disease.


Stage IIA1 Cervical Cancer FIGO 2009

Cervical carcinoma limited to the upper two-thirds of the vagina and is equal or less than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Muscle Disorder

A non-neoplastic disorder that affects the smooth, skeletal, or cardiac muscles.


Stage IIA Cervical Cancer FIGO 2018

Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement. (FIGO 2018)


Stage IB1 Cervical Cancer AJCC v8

Stage IB1 includes: T1b1, Any N, M0. T1b1: Tumor with clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Cervical Cancer AJCC v8

Stage IIA includes: T2a, Any N, M0. T2a: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Refractory Endometrial Mixed Cell Adenocarcinoma

Endometrial mixed cell adenocarcinoma that is resistant to treatment.


Cervical Squamous Cell Carcinoma, Not Otherwise Specified

Cervical squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


Stage IIIA Cervical Cancer AJCC v8

Stage IIIA includes: T3a, Any N, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IB2 Cervical Cancer FIGO 2009

Cervical carcinoma measuring more than 5 mm in depth and more than 4 cm in maximum diameter. (FIGO 2009)


Cervical Cancer by AJCC v6 Stage

A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 6th edition.


Non-Neoplastic Hepatobiliary Disorder

A non-neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples include hepatitis, cirrhosis, cholangitis, and cholecystitis.


Stage IVA Cervical Cancer FIGO 2009

Cervical carcinoma with rectal or bladder involvement. (FIGO 2009)


Laboratory Test Result

The outcome of a laboratory test.


Residual schizophrenia

A subtype of schizophrenia in which the individual has suffered an episode of schizophrenia but there are no longer any delusions, hallucinations, disorganized speech or behavior. Residual symptoms are seen in the form of negative symptoms (such as flat affect or avolition) or attenuated positive symptoms (such as odd beliefs).


FIGO Grade 3 Endometrial Mucinous Adenocarcinoma

A primary mucinous adenocarcinoma of the endometrium that contains more than 50% non-squamous solid areas.


Unresectable Cervical Carcinoma

Cervical carcinoma that is not amenable to surgical resection.


A trans-1,2-dihydronaphthalene-1,2-diol with a (1R,2R)-configuration.


The (1S,2S)-isomer of trans-1,2-dihydronaphthalene-1,2-diol.


Methamphetamine Hydrochloride

A hydrochloride having methamphetamine as the base component.


A 3beta-sterol that consists of 24-methylcholest-6-en-3beta-ol with a peroxy group between positions 5 and 8 and a methylene group between positions 22 and 23. An antineoplastic agent isolated from  Sinularia sp.


SKF 77434 hydrobromide

A hydrobromide salt prepared from N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol and one equivalent of hydrogen bromide. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.


A D-proline derivative that is D-proline monohydroxylated at position 3 (the cis-3-hydroxy-diastereomer).


hydroxyproline

A proline derivative that is proline substituted by at least one hydroxy group.


The (3R)-trans--diastereomer of 3-hydroxy-D-proline.


The D-stereoisomer of 4-hydroxyproline.


The L-stereoisomer of 3-hydroxyproline.


monohydroxyproline

A hydroxy-amino acid in which the amino acid specified is proline. A "closed" class.


DL-Pyroglutamic acid

An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.


oxoproline

A pyrrolidinemonocarboxylic acid consisting of proline bearing a single oxo substituent.


The (3R)-cis-diastereomer of 3-hydroxy-L-proline.


The L-stereoisomer of 4-hydroxyproline.


L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).


(R)-Clenbuterol hydrochloride

The monohydrochoride salt of (R)-clenbuterol.


A dihydroisorhamnetin that has 2R,3R-configuration.


The (25R)-diastereomer of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al.


Colchicine

A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.


(R)-colchicine

A colchicine that has (R)-configuration.


haloindole

A compound based on an indole skeleton, containing one or more halogen atoms


(-)-spongotine A

A member of the class of imidazolines that is 4,5-dihydro-1H-imidazole which is substituted by a 1H-indole-3-carbonyl group at position 2 and a 6-bromo-1H-indol-3-yl group at position 4S. It is a bisindole alkaloid isolated from the marine sponge, Spongosorites sp.


A pyrrole-2,5-dicarboxylic acid having 7-chloroindol-3-yl groups at the 3- and 4-positions.


chloroindole

A compound based on an indole skeleton, containing one or more chlorine atoms


Isoxazole

A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of  isoxazoles.


An enone that is pent-2-ene in which the two methylene hydrogens have been replaced by an oxo group.


Magnesium chloride, monohydrate

A hydrate that is the monohydrate form of magnesium dichloride.


Magnesium Chloride

A magnesium salt comprising of two chlorine atoms bound to a magnesium atom.


Magnesium dichloride dihydrate

A hydrate that is the dihydrate form of magnesium dichloride.


A UDP-sugar in which the sugar component is rhamnose.


uridine 5'-[3-(L-rhamnopyranosyl) dihydrogen diphosphate]

A UDP-rhamnose in which the rhamnose component has L-configuration.


Amorolfine hydrochloride

A hydrochloride resulting from the formal reacton of equimolar amounts of hydrogen chloride and amorolfine. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used for the topical treatment of fungal nail and skin infections.


nutrient

A nutrient is a food component that an organism uses to survive and grow.


D-glyceraldehyde

The D-enantiomer of glyceraldehyde.


The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.


The dihydrate of a tris(1,10-phenanthroline)ruthenium(2+) dichloride salt.


(24S)-24-hydroxycholesterol 3-hexanoate

A sterol ester that is the 3-hexanoyl derivative of (24S)-24-hydroxycholesterol.


hexanoate ester

Any fatty acid ester where the carboxylic acid component is hexanoic (also known as caproic) acid.


Hydrocortisone caproate

The 21-O-hexanoyl derivative of hydrocortisone.


3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al with S-configuration at C-24.


Oxazole

A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.


Dihydroconiferyl alcohol

A member of class of phenols that is 2-methoxyphenol substituted by a 3-hydroxypropyl group at position 4.


H-1152 Dihydrochloride

A hydrochloride salt resulting from the reaction of (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane with 2 mol eq. of hydrogen chloride. An ATP-competitive inhibitor of Rho kinase (ROCK).


indole

Either of two isomeric forms comprising a benzene ring fused to a pyrrole ring.


Benzoxazole

A benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5.


long-chain primary fatty alcohol

A long-chain fatty alcohol in which the hydroxy group is attached to a methylene (CH2) group.


An  oxysterol that is cholesterol substituted  by hydroxy groups at positions 20 and 22 (the 20R,22R-stereoisomer).


(R)-cyclopentolate

The (R)-enantiomer of cyclopentolate.


(S)-cyclopentolate

The (S)-enantiomer of cyclopentolate.


deoxyviolacein

A member of the class of oxindoles resulting from formal oxidative coupling between the 3-position of 1,3-dihydro-2H-indol-2-one and the 3-position of 1,3-dihydro-2H-pyrrol-2-one, which is substituted at the 5 position by a 1H-indol-3-yl group, where the newly-formed double bond has E configuration.


fatty acid 16:2

Any polyunsaturated fatty acid containing 16 carbons and 2 double bonds.


tetramine

Any polyamine that contains four amino groups.


Acrovestone

A polyphenol that is isolated from Acronychia pedunculata and exhibits moderate antioxidant and antityrosinase activities.


nucleobase analogue

A molecule that can substitute for a normal nucleobase in nucleic acids.


methylthymine

A pyrimidone that is thymine bearing a single methyl substituent.


A member of the class of pyrrolecarboxamides that is 1H-pyrrole substituted by [1-(3a,7a-dihydro-1,3-benzodioxol-5-ylmethyl)-1H-imidazol-5-yl]methyl, (4-methylpiperazin-1-yl)carbonyl, and naphthalen-1-yl groups at positions 1, 3 and 4, respectively. It is a potent inhibitor of Ras farnesyltransferase (IC50= 0.9nM against H-Ras and 2.4nM against K-Ras) with potential anticancer activity.


Bambuterol hydrochloride, (S)-

The hydrochloride salt of (S)-bambuterol.


L-cysteine thioether

Any L-cysteine derivative obtained by conversion of the thiol group into a sulfide.


oxoicosatetraenoic acid

Any C20 polyunsaturated fatty acid having four double bonds and at least one oxo group.


2-Propenoic acid, 3-phenyl-

A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia.


A member of the class of  pyrroles that is 2,3-dihydro-1H-pyrrole substituted by a 9-methyl-8,10-dioxodec-2-en-10-yl group at the nitrogen atom. Isolated from Penicillium citrinum and Penicillium brevicompactum, it exhibits antifungal activity.


zinc cation

Any zinc ion that is positively charged.


Thiencarbazone-methyl

An N-sulfonylurea in which the sulfur atom is attached to a 4-(methoxycarbonyl)-2-methylthiophen-3-yl group and in which the non-sulfonated nitrogen is substituted by a 3-methoxy-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl group. It is a herbicide used for the selective control of grasses and broadleaf weeds primarily in corn.


D-Cellobiose

A glycosylglucose consisting of two glucose units linked via a beta(1->4) bond.


Lactobiose

A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.


D-Glucose

A glucopyranose having D-configuration.


D-glucose

A glucose with D-configuration.


2,3-saturated fatty aldehyde

Any fatty aldehyde that is saturated at positions 2 and 3.


Mefloquine hydrochloride

A racemate composed of (+)-(11R,2'S)- and (-)-(11S,2'R)-enantiomers of mefloquine. An antimalarial agent which acts as a blood schizonticide; its mechanism of action is unknown.


Decarboxytiaprofenic acid

A thiophene substituted at C-2 by benzoyl and at C-4 by an ethyl group.


D-Mannose

D-Mannose in its six-membered ring form.


A 3beta-sterol that is 5alpha-ergosta-7,24(28)-diene which is substituted at the  3beta and 4alpha positions by hydroxy and formyl groups, respectively.


A 3-hydroxy steroid that is 24-methylene-19-norcholesta-1,3,5(10)-triene substituted by a hydroxy group at position 3. It is isolated from Hainan soft coral Dendronephthya studeri.


An androstanoid that is androstane substituted by oxo groups at positions 3 and 17.


Cadaverine dihydrochloride

A hydrochloride resulting from the reaction of cadaverine with 2 mol eq. of hydrogen chloride.


PHOSPHORUS P-33

The radioactive isotope of phosphorus with relative atomic mass 32.971725, half-life of 25.34 days and nuclear spin (1)/2.


A steroid glucosiduronic acid that is 4-hydroxyestrone having a single beta-D-glucuronic acid residue attached at position 3.


saturated fatty aldehyde

A fatty aldehyde in which there is no carbon-carbon unsaturation.


CID 657192

The hydrochloride salt of mianserin, a tetracyclic compound with antidepressant effects.


quinone

Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).


Menaquinone 10

Any member of the class of menaquinones that is 2-methyl-1,4-naphthoquinone with an unsaturated isoprenoid chain at the 3-position.


Vitamin K

Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.


polyprenylbenzoquinone

Any member of the class of 1,4-benzoquinones substituted by a polyprenyl-derived side-chain.


Any 1,4-benzoquinone carrying a single hydroxy substituent.


A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.


hydroxyanthraquinones

An anthraquinone substituted with one or more hydroxy groups.


prenylquinone

A quinone substituted by a polyprenyl-derived side-chain. Prenylquinones occur in all living cells. Due to their amphiphilic character, they are mainly located in biological membranes where they function as electron and proton carriers in the photosynthetic and respiratory electron transport chains. Some prenylquinones also perform more specialised roles sucy as antioxidants and enzyme cofactors. Prenylquinones are classified according to ring structure: the main classes are menaquinones, phylloquinones, ubiquinones and plastoquinones.


Any member of the class of benzoquinones that is 1,4-benzoquinone or its C-substituted derivatives.


acenoquinone

Quinones containing an acene fused ring system.


hydroxybenzoquinone

Benzoquinones with at least one hydroxy substituent.


orthoquinones

Any quinone in which the carbons of the two carbonyl groups in the quinone system are joined to each other by a single bond.


Coenzyme Q6

A ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2.


menaquinones

Any prenylnaphthoquinone having a prenyl or polyprenyl group at position 3 and a methyl group at position 2 on the naphthoquinone ring.


prenylnaphthoquinone

Any napthoquinone that is substituted at position 2 by a prenyl or polyprenyl group. The term also includes compounds that are functionalised on the prenyl or polyprenyl chain (e.g. by a hydroxy group).


Any napthoquinone in which the oxo groups of the quinone moiety are at the 1 and 2 positions of the naphthalene ring.


p-quinones

A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring.


Ubiquinone 7

A compound whose structure comprises a 2,3-dimethoxy-5-methylbenzoquinone nucleus, common to ubiquinones; and a side chain of seven isoprenoid units.


A geometric isomer of ubiquinone-10 in which the double bonds at positions 2, 10 and 26 are in the Z conformation.


A polycyclic aromatic ketone metabolite of naphthalene.


Coenzyme Q8

A ubiquinone whose structure comprises a 2,3-dimethoxy-5-methylbenzoquinone nucleus (common to all ubiquinones) and a side chain of eight isoprenoid units.


Ubiquinone 25

A compound composed of the 2,3-dimethoxy-5-methylbenzoquinone nucleus common to ubiquinones; and a side chain of five isoprenoid units.


Any member of the class of orthoquinones that is 1,2-benzoquinone or its C-substituted derivatives.


A naphthoquinone in which the oxo groups of the quinone moiety are at positions 1 and 4 of the parent naphthalene ring.


benzoquinones

Any quinone resulting from the formal oxidation of catechol, hydroquinone, or their C-substituted derivatives.


A derivative of benzoquinone carrying a 5-methyl substituent; and methoxy substituents at positions 2 and 3. The core structure of the ubiquinone group of compounds.


hydroxyquinone

Any quinone in which one or more of the carbons making up the quinone moiety is substituted by a hydroxy group.


N-acetylglucosamine

An N-acylglucosamine where the N-acyl group is specified as acetyl.


(R)-Bifonazole

A 1-[biphenyl-4-yl(phenyl)methyl]imidazole that is the R-enantiomer of bifonazole.


A pyridinium ion obtained by protonation of the ring nitrogen of pyridoxal.


DL-Alanine

An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.


L-4-hydroxy-2-oxoglutaric acid

An optically active form of 4-hydroxy-2-oxoglutaric acid having L-configuration.


CMP-N-acyl-beta-neuraminic acid

A CMP-sugar in which the sugar component consists of any N-acyl-beta-neuraminic acid.


A pyrrole carrying methyl and acetyl substituents at the 1- and 2-positions respectively.


xylonic acid

A pentonic acid resulting from the formal oxidation of the aldehyde group of aldehydo-xylose to the corresponding carboxylic acid.


N-acetyl-L-((13)C4)aspartic acid

A (13)C-modified compound that is N-acetyl-L-aspartic acid in which the carbon atoms at postions 1, 2, 3 and 4 are present as their (13)C isotopes. Used in biological studies for metabolic alterations associated with schizophrenia.


A C3 cyanine dye having 3-ethyl-1,3-benzoxazol-2(3H)-yl units at each end.


1,3-Dimethylimidazolium iodide

An organic iodide salt in which the cationic component is 1,3-dimethylimidazolium.


Ethyltrimethylammonium iodide

A quarternary ammonium salt whose basic unit comprises an ethyltrimethylammonium cation and an iodide anion.


Pralidoxime iodide

An organic iodide salt that has pralidoxime as the cation.


4-Damp methiodide

A quaternary ammonium salt obtained by combining equimolar amounts of 4-diphenylacetoxy-N-methylpiperidine and iodomethane.


Sodium Iodide

A metal iodide salt with a Na(+) counterion.


A C3 cyanine dye having 1-ethyl-3,3-dimethylindoleinine units at each end.


monoiodotyrosine

An  iodotyrosine carrying a single iodo substituent.


iodothyronine

An  iodoamino acid in which the amino acid specified is  thyronine.


iodotyrosine

A tyrosine derivative which has at least one iodo-substituent on the benzyl moiety.


Ammonium iodatum

The iodide salt of ammonia.


A quaternary ammonium salt that is the monoiodide salt of acetyl-beta-methylthiocholine.


Buzepide metiodide

An organic iodide salt of buzepide. It is a component of the antispasmodic drug vesadol.


A C1 cyanine dye having benzothiazolium-2-yl and quinolinium-4-yl substituents.


An organic iodide salt consisting of pyridinium iodide having a methyl substituent at the 1-position and a 4-dimethylaminostyryl substituent at the 4-position.


organoiodine compound

An organoiodine compound is a compound containing at least one carbon-iodine bond.


An unsymmetrical C3 cyanine dye having 1,3-benzoxazol-2-yl and quinolinium-4-yl substituents.


diiodotyrosine

A dihalogenated L-tyrosine which has two iodo-substituents on the benzyl moiety.


1-Butyl-3-methylimidazolium Iodide

An organic iodide salt in which the cationic component is 1-butyl-3-methylimidazolium.


poly(N-methyl-2-vinylpyridinium iodide)

A polymer composed of repeating N-methyl-2-ethylpyridinium iodide units.


iodoamino acid

An amino acid containing at least one iodo substituent.


A C7 cyanine dye having 3-ethyl-1,3-benzoxazol-2(3H)-yl units at each end.


An unsymmetrical C1 cyanine dye having 1,3-benzoxazol-2-yl and quinolinium-4-yl substituents.


An organic iodide salt consisting of pyridinium iodide having a methyl substituent at the 1-position and a 4-diethylaminostyryl substituent at the 4-position.


A C7 cyanine dye having 1-ethyl-3,3-dimethylindoleinine units at each end.


D-glucuronic acid 1-phosphate

A uronic acid phosphate consisting of D-glucuronic acid having a phosphate group attached at the 1-position.


benzyl alcohols

Compounds containing a phenylmethanol skeleton.


The (S,S) diastereoisomer of butane-2,3-diol.


The meso diastereoisomer of butane-2,3-diol.


aflatoxin

Any of a group of related and highly toxic secondary metabolites (mycotoxins) whose main structural feature is a fused coumarin-bis(dihydrofuran) ring system and which are produced by strains of the moulds Aspergillus flavus or A. parasiticus, together with further metabolites of these mycotoxins


Fluocinolone acetonide

A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders.


Stanozolol

An organic heteropentacyclic compound resulting from the formal condensation of the 3-keto-aldehyde moiety of oxymetholone with hydrazine. Like oxymetholone, it is a synthetic anabolic steroid. It has both anabolic and androgenic properties, and has been used to treat hereditary angioedema and various vascular disorders. It has also been widely abused by professional athletes.


hemiaminal

Any organic amino compound that has an amino group and a hydroxy group attached to the same carbon atom. Hemiaminals are intermediates in the formation of imines by addition of an amine to an aldehyde or ketone; those derived from primary amines are particularly unstable.


(S)-Nadphx

A tetrahydronicotinamide adenine dinucleotide obtained by formal stereo- and regioselective hydration across the 2,3-double bond in the nicotinyl ring of NADPH, with the hydroxy group located at position 2, having (S)-configuration.


(R)-Nadphx

A tetrahydronicotinamide adenine dinucleotide obtained by formal stero- and regioselective hydration across the 2,3-double bond in the nicotinyl ring of NADPH, with the hydroxy group located at position 2, having (R)-configuration.


A tetrahydropterin that is 5,6,7,8-tetrahydrobiopterin carrying an additional hydroxy substituent at the 4a-position.


(R)-Nadhx

A tetrahydronicotinamide adenine dinucleotide obtained by formal stereo- and regioselective hydration across the 5,6-double bond in the nicotinyl ring of NADH, with the hydroxy group located at position 6, having (R)-configuration.


(S)-Nadhx

A tetrahydronicotinamide adenine dinucleotide obtained by formal stereo- and regioselective hydration across the 5,6-double bond in the nicotinyl ring of NADH, with the hydroxy group located at position 6, having (S)-configuration.


Diflorasone diacetate

The 17,21-diacetate derivative of diflorasone. It is used topically for its anti-inflammatory and antipruritic properties in the treatment of various skin disorders.


Beclomethasone

A 17alpha-hydroxy steroid that is prednisolone in which the hydrogens at the 9alpha and 16beta positions are substituted by a chlorine and a methyl group, respectively.


Fluorometholone acetate

A steroid ester resulting from the formal condensation of the 17-hydroxy function of fluorometholone with acetic acid. Used in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.


A 11alpha-hydroxy steroid that is pregn-4-ene-3,20-dione substituted by a hydroxy group at position 11.


A 3-oxo Delta(4)-steroid that is (22S)-22-hydroxycampest-4-en-3-one bearing an additional hydroxy substituent at position 23R.


A member of the class of quinolones that is 1,2,3,4-tetrahydroquinoline in which the hydrogens at positions 2 and 4 have been replaced by oxo groups.


A 3-oxo-5beta-steroid formed from corticosterone by reduction across the C4-C5 double bond.


An anabolic steroid that differs from testosterone by having a 1,2-double bond instead of a 4,5-double bond in its A ring. A potent androgen with anabolic properties, it was legally sold as a prohormone in the U.S.A. until 2005, when it was reclassified as a Schedule III drug.


A 16-hydroxy steroid that is prednisolone carrying a hydroxy group at the 16 position.


An androstanoid having a double bond at C-5, an oxo group at C-3 and a hydroxy group with beta-configuration at C-17.


A C21-steroid that is pregnane which contains a double bond between positions 4 and 5 and is substituted by an oxo group at position 3 and a hydroxy group at position 20.


An androstanoid that is androst-4-ene-3,17-dione in which the hydrogen at the 1alpha position has been replaced by a hydroxy group.


Triamcinolone Acetonide

A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.


A glucocorticoid that is prednisone in which a double bond is introduced at position 6. It is a metabolite of prednisone found in human urine.


A 3-oxo-Delta(4)-steroid that is progesterone in which the hydrogen at the 6beta-position is substituted by a hydroxy group.


Clocortolone

16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9. A medium potency corticosteroid, it is used as its 21-O-pivalate or caproate ester for the relief of inflammatory and pruritic (itching) skin disorders.


Alclometasone dipropionate

A prednisolone compound having an alpha-chloro substituent at the 7-position, an alpha-methyl substituent at the 16-position and O-propanoyl groups at the 17- and 21-positions.


3-oxo Delta(7)-steroid

Any 3-oxo steroid which also contains a double bond between positions 7 and 8.


A steroid glucosiduronic acid that is 16alpha-hydroxyestrone in which the hydroxy hydrogen at position 16 has been replaced by a beta-D-glucuronyl residue.


Any flavanone in which the chiral centre at position 2 has S-configuration.


Dihydromyricetin

An optically active form of dihydromyricetin having (2R,3R)-configuration.


Methylprednisolone 21-suleptanic acid ester

A carboxylic ester resulting from the formal condensation of the 21-hydroxy group of 6alpha-methylprednisolone with the carboxy group of 8-[methyl(2-sulfoethyl)amino]-8-oxooctanoic acid.


Mibolerone

An androgen that is nalandrone carrying two methyl substituents at positions 7alpha and 17.


Any hydroxyflavanone with a hydroxy substituent at position 3' of the phenyl ring.


An  androstanoid that is 5alpha-androstane substituted by a methyl group at position 4, a hydroxy group at position 17 and an oxo group at position 3.


7alpha,12alpha,24-trihydroxycholest-4-en-3-one with S-configuration at C-24.


A steroid aldehyde that is cortisol carrying a formyl group at position 18.


hydroxyflavanone

A member of the class of flavanones that consists of flavanone with one or more hydroxy substituents.


A 3-oxo Delta(4)-steroid that is estr-4-ene substituted by an oxo group at position 3, methyl groups at positions 2 and 17 and a beta-hydroxy group at position 17.


Any  oxo steroid carrying the oxo group at position 17.


A 3-oxo-5alpha- steroid that is 4,5alpha-dihydrotestosterone which is substituted by a hydroxymethylidene group at position 2 and by a methyl group at the 17alpha position. A synthetic androgen, it was mainly used for the treatment of anaemias until being replaced by treatments with fewer side effects.


Desoximetasone

Dexamethasone in which the hydroxy group at the 17alpha position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin disorders, including skin allergies and psoriasis.


A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.


A 6alpha-hydroxy steroid that is estrone substituted by an alpha-hydroxy group at position 6.


A steroid acid that is 23,24-bisnor-chol-1,4-dien-22-oic acid bearing additional oxo and hydroxy substituent at positions 3 and 9 respectively.


anthracenone

Any member of the class of anthracenes in which the anthracene moiety is substituted by an oxo group.


Epiandrosterone

A 3beta-hydroxy steroid that is (5alpha)-androstane substituted by a beta-hydroxy group at position 3 and an oxo group at position 17.


(-)-Dihydromyricetin

The (2S,3S)-stereoisomer of dihydromyricetin.


A 18-hydroxy steroid that is cortisol carrying a hydroxy group at position 18. Its urinary excretion is increased in patients with aldosterone-producing adenoma.


A 3beta-hydroxy steroid that is epiandrosterone carrying a hydroxy group at the 7beta position. It is an endogenous androgen metabolite that has been shown to exert neuroprotective effects.


Boldenone

An  3-oxo-Delta(1),Delta(4)-steroid substituted by an oxo group at position 3 and a beta-hydroxy group at position 17. It is an  anabolic androgenic steroid that has been developed for veterinary use.


A brassinosteroid that is 5alpha-campestane bearing an oxo substituent at position 3.


Dienogest

A steroid hormone that is 17beta-hydroxy-3-oxoestra-4,9-diene substituted at position 17 by a cyanomethyl group. Used as an oral contraceptive.


A 3-oxo Delta(4)-steroid that is testosterone which is substituted by a hydroxy group at positions 19.


6alpha-Fluorohydrocortisone 21-acetate

A steroid ester that is pregn-4-en-21-yl acetate substituted by oxo groups at positions 3 and 20, hydroxy groups at positions 11 and 17 and a fluoro group at position 6.


A glucocorticoid that is prednisolone carrying a hydroxy group at the 6alpha position. It is a metabolite of prednisolone found in human urine.


Any oxo steroid where an oxo substituent is located at position 3.


Desonide

Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.


7alpha,12alpha,24-Trihydroxy-5beta-cholestan-3-one with S-configuration at C-24.


A 3-hydroxy steroid that is estrone substituted by a beta-hydroxy group at position 6.


An androstanoid that is testosterone substituted by a alpha-hydroxy group at position 7. A natural product found in Daphnia magna exposed to the biocide tributyltin


Betamethasone valerate

A steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester.


Formestane

A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.


A glucocorticoid that is prednisone in which the oxo group at position 20 is replaced by a hydroxy group. It is a metabolite of prednisone found in human urine.


A 3-oxo-5alpha- steroid that is 5alpha-cholestane substituted by an oxo group at position 3.


Methylprednisolone acetate

An acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid.


Any methoxyflavanone having a methoxy substituent located at position 4'.


A 3-oxo-Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17 and a hydroxy group at position 9.


cyclohexanones

Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.


An androstanoid that is 5alpha-dihydrotestosterone carrying an additional oxo susbstituent at position 19.


A 3-oxo Delta(4)-steroid that is 3-oxochola-4,6-dien-24-oic acid carrying an additional hydroxy group at the 12alpha-position.


A cholestanoid that consists of 3-oxocholest-4-ene bearing a hydroxy substituent at position 26.


A 26-hydroxycholest-4-en-3-one in which the 25-position has R-configuration.