ubiquitin carboxyl-terminal hydrolase 10, initiator methionine removed form (human)

A ubiquitin carboxyl-terminal hydrolase 10 (human) that has had the initiator methionine removed. UniProtKB:Q14694, 2-798.


protocadherin gamma-A8

A protocadherin gamma that is a translation product of the human PCDHGA8 gene or a 1:1 ortholog thereof.


tyrosine-protein kinase ABL2 isoform h2 (human)

A tyrosine-protein kinase ABL2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42684-2.


TGF-beta receptor type-2 sequence variant T315M (human)

A TGF-beta receptor type-2 (human) that has a Met residue at the position equivalent to Thr-315 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Thr-315, CHEBI:16044.


albumin isoform h1 (human)

An albumin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02768-1.


ubiquitin-conjugating enzyme E2 N isoform 1 (human)

A ubiquitin-conjugating enzyme E2 N isoform 1 that is encoded in the genome of human.


arfaptin-2 isoform 1 (human)

An arfaptin-2 isoform 1 that is encoded in the genome of human.


NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 isoform 1 (human)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 isoform 1 that is encoded in the genome of human.


cytochrome c oxidase subunit 5B, mitochondrial

A protein that is a translation product of the human COX5B gene or a 1:1 ortholog thereof.


dual specificity protein phosphatase 2

A protein that is a translation product of the human DUSP2 gene or a 1:1 ortholog thereof.


ADP-sugar pyrophosphatase

A protein that is a translation product of the human NUDT5 gene or a 1:1 ortholog thereof.


C-X-C chemokine receptor type 4 isoform mCXCR4-B (mouse)

A C-X-C chemokine receptor type 4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70658-1.


ELAV-like protein 4 isoform m7 (mouse)

An ELAV-like protein 4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61701-8.


aspartyl/asparaginyl beta-hydroxylase isoform h7 (human)

An aspartyl/asparaginyl beta-hydroxylase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12797-7.


amiloride-sensitive sodium channel subunit gamma

An epithelial sodium channel protein that is a translation product of the human SCNN1G gene or a 1:1 ortholog thereof.


ATPase family AAA domain-containing protein 2 isoform h1 (human)

An ATPase family AAA domain-containing protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6PL18-1.


protein phosphatase methylesterase 1 isoform h4 (human)

A protein phosphatase methylesterase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y570-4.


palmitoyltransferase ZDHHC6 isoform 1 (human)

A palmitoyltransferase ZDHHC6 isoform 1 that is encoded in the genome of human.


guanine nucleotide exchange factor VAV3 phosphorylated 1 (human)

A guanine nucleotide exchange factor VAV3 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-173 of the amino acid sequence represented by UniProtKB:Q9UKW4. UniProtKB:Q9UKW4, Tyr-173, MOD:00048.


T-cell surface glycoprotein CD1e, membrane-associated isoform h5 (human)

A T-cell surface glycoprotein CD1e, membrane-associated (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15812-5.


elongation factor G, mitochondrial

A protein that is a translation product of the human GFM1 gene or a 1:1 ortholog thereof.


collagen alpha-1(XVIII) chain O-glycosylated 13 (human)

A collagen alpha-1(XVIII) chain (human) that has been O-glycosylated at the residue equivalent to Ser-79 of the amino acid sequence represented by UniProtKB:P39060-3, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P39060-3, Ser-79, MOD:00002~GNO:G43417UB.


prostaglandin-H2 D-isomerase N-glycosylated 22 (human)

A prostaglandin-H2 D-isomerase (human) that has been N-glycosylated at the residue equivalent to Asn-78 of the amino acid sequence represented by UniProtKB:P41222-1, in which the glycan structure is represented by GlyTouCan:G96095QD. Example: UniProtKB:P41222-1, Asn-78, MOD:00160~GNO:G96095QD.


methyl-CpG-binding domain protein 1 isoform m5 (mouse)

A methyl-CpG-binding domain protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2E2-5.


heparan sulfate glucosamine 3-O-sulfotransferase 3A1

A protein that is a translation product of the human HS3ST3A1 gene or a 1:1 ortholog thereof.


versican core protein O-glycosylated 43 (human)

A versican core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2827 of the amino acid sequence represented by UniProtKB:P13611-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P13611-1, Ser-2827, MOD:00002~GNO:G43417UB.


vitamin D3 receptor

A protein that is a translation product of the human VDR gene or a 1:1 ortholog thereof.


endothelin receptor type B

An endothelin receptor that is a translation product of the human EDNRB gene or a 1:1 ortholog thereof. The active form binds endothelin 1 (ET-1), ET-2, and ET-3 with equal affinity.


neuroendocrine convertase 2 isoform h1 (human)

A neuroendocrine convertase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16519-1.


cAMP-dependent protein kinase catalytic subunit beta isoform h9 (human)

A cAMP-dependent protein kinase catalytic subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22694-9.


dual specificity protein phosphatase 13 isoform 5 (human)

A dual specificity protein phosphatase 13 isoform 5 that is encoded in the genome of human.


free fatty acid receptor

A rhodopsin-like G-protein coupled receptor that is a translation product of the human FFAR1 to FFAR4, or GPR42 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds free fatty acid.


hemopexin N-glycosylated 31 (human)

A hemopexin (human) that has been N-glycosylated at the residue equivalent to Asn-64 of the amino acid sequence represented by UniProtKB:P02790-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P02790-1, Asn-64, MOD:00160~GNO:G22140GZ.


Rap guanine nucleotide exchange factor 6 isoform h5 (human)

A Rap guanine nucleotide exchange factor 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TEU7-5.


calcium-transporting ATPase type 2C member 2 isoform h3 (human)

A calcium-transporting ATPase type 2C member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75185-3.


protein arginine N-methyltransferase 6

A protein that is a translation product of the human PRMT6 gene or a 1:1 ortholog thereof.


short transient receptor potential channel 7 isoform 1 (human)

A short transient receptor potential cation channel TRPC7 isoform 1 that is encoded in the genome of human.


protocadherin gamma-A7 isoform h1 (human)

A protocadherin gamma-A7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5G6-1.


phosphorylase b kinase gamma catalytic chain, liver/testis isoform

A protein that is a translation product of the human PHKG2 gene or a 1:1 ortholog thereof.


CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform hB1+32 (human)

A CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q11203-6.


A protein that is a translation product of the human CHD9 gene or a 1:1 ortholog thereof.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

A protein that is a translation product of the human PTEN gene or a 1:1 ortholog thereof.


propionyl-CoA carboxylase beta chain, mitochondrial, transit peptide removed form (human)

A propionyl-CoA carboxylase beta chain, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P05166, 29-539.


alpha-synuclein isoform 1 (human)

An alpha-synuclein isoform 1 that is encoded in the genome of human.


nuclear factor of activated T-cells, cytoplasmic 4 isoform h1 (human)

A nuclear factor of activated T-cells, cytoplasmic 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14934-1.


fibronectin isoform h11 (human)

A fibronectin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02751-11.


ephrin type-B receptor 6 isoform h3 (human)

An ephrin type-B receptor 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15197-3.


A cadherin that is a translation product of the human DSG1 gene or a 1:1 ortholog thereof.


ubiquinone biosynthesis protein COQ7

A protein that is a translation product of the human COQ7 gene or a 1:1 ortholog thereof.


membrane-bound transcription factor site-1 protease

A protein that is a translation product of the human MBTPS1 gene or a 1:1 ortholog thereof.


alpha-fetoprotein N-glycosylated 10 (human)

An alpha-fetoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-251 of the amino acid sequence represented by UniProtKB:P02771-1, in which the glycan structure is represented by GlyTouCan:G30460NZ. Example: UniProtKB:P02771-1, Asn-251, MOD:00160~GNO:G30460NZ.


PI-PLC X domain-containing protein 2 isoform h2 (human)

A PI-PLC X domain-containing protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q0VAA5-2.


protein unc-13 homolog B isoform h2 (human)

A protein unc-13 homolog B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14795-2.


aurora kinase B unphosphorylated form (human)

An aurora kinase B unphosphorylated form in human.


aconitate hydratase, mitochondrial, transit peptide removed form (human)

An aconitate hydratase, mitochondrial (human) that has had the transit peptide removed. UniProtKB:Q99798, 28-780.


glutamate decarboxylase 2

A protein that is a translation product of the human GAD2 gene or a 1:1 ortholog thereof.


dual specificity protein kinase CLK2

A protein that is a translation product of the human CLK2 gene or a 1:1 ortholog thereof.


mineralocorticoid receptor isoform h1 (human)

A mineralocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08235-1.


aggrecan core protein O-glycosylated 16 (human)

An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1929 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-1929, MOD:00002~GNO:G53434XO.


glycerate kinase isoform h7 (human)

A glycerate kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IVS8-7.


A protein that is a translation product of the human METTL3 gene or a 1:1 ortholog thereof.


serum paraoxonase/arylesterase 1

A protein that is a translation product of the human PON1 gene or a 1:1 ortholog thereof.


mitogen-activated protein kinase 12 isoform h2 (human)

A mitogen-activated protein kinase 12 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P53778-2.


ubiquitin-protein ligase E3A isoform II (human)

A ubiquitin-protein ligase E3A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05086-1.


aminopeptidase N O-glycosylated 4 (human)

An aminopeptidase N (human) that has been O-glycosylated at the residue equivalent to Thr-56 of the amino acid sequence represented by UniProtKB:P15144-1, in which the glycan composition is represented by GlyTouCan:G27391WQ. Example: UniProtKB:P15144-1, Thr-56, MOD:00005~GNO:G27391WQ.


formimidoyltransferase-cyclodeaminase isoform C (human)

A formimidoyltransferase-cyclodeaminase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95954-2.


tau-tubulin kinase 2

A protein that is a translation product of the human TTBK2 gene or a 1:1 ortholog thereof.


palmitoyltransferase ZDHHC2

A protein that is a translation product of the human ZDHHC2 gene or a 1:1 ortholog thereof.


cytosolic phospholipase A2 delta isoform h2 (human)

A cytosolic phospholipase A2 delta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86XP0-2.


DNA polymerase beta isoform 1 (human)

A DNA polymerase beta isoform 1 that is encoded in the genome of human.


sterol O-acyltransferase 2 isoform h1 (human)

A sterol O-acyltransferase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75908-1.


RNA-splicing ligase RtcB

A protein that is a translation product of the Escherichia coli K-12 rtcB gene or a 1:1 ortholog thereof.


myosin-IIIb isoform h6 (human)

A myosin-IIIb (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WXR4-6.


prostaglandin E synthase 3 isoform h2 (human)

A prostaglandin E synthase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15185-2.


mannose-1-phosphate guanyltransferase alpha isoform h2 (human)

A mannose-1-phosphate guanyltransferase alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96IJ6-2.


kallikrein-1 N-glycosylated 34 (human)

A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G23484GM. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G23484GM.


transmembrane protein 132A isoform h3 (human)

A transmembrane protein 132A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q24JP5-3.


cyclic nucleotide-gated cation channel alpha-3 sequence variant R283Q (human)

A cyclic nucleotide-gated cation channel alpha-3 (human) that has a Gln residue at the position equivalent to Arg-283 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Arg-283, CHEBI:30011.


DNA-directed RNA polymerases I, II, and III subunit RPABC3

A protein that is a translation product of the human POLR2H gene or a 1:1 ortholog thereof.


kallikrein-1 N-glycosylated 11 (human)

A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G85542KD. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G85542KD.


iodotyrosine deiodinase 1 isoform h7 (human)

An iodotyrosine deiodinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6PHW0-7.


single-strand selective monofunctional uracil DNA glycosylase isoform h1 (human)

A single-strand selective monofunctional uracil DNA glycosylase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q53HV7-1.


probable proline--tRNA ligase, mitochondrial

A protein that is a translation product of the human PARS2 gene or a 1:1 ortholog thereof.


general transcription and DNA repair factor IIH helicase subunit XPD

A protein that is a translation product of the human ERCC2 gene or a 1:1 ortholog thereof.


phospholipid phosphatase-related protein type 3 isoform h1 (human)

A phospholipid phosphatase-related protein type 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6T4P5-1.


pterin-4-alpha-carbinolamine dehydratase, initiator methionine removed form (human)

A pterin-4-alpha-carbinolamine dehydratase, initiator methionine removed form in human. UniProtKB:P61457, 2-104.


2-oxoglutarate dehydrogenase-like, mitochondrial isoform h1 (human)

A 2-oxoglutarate dehydrogenase-like, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ULD0-1.


2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform h1 (human)

A 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6N063-1.


mitogen-activated protein kinase kinase kinase 20 isoform ZAKalpha (human)

A mitogen-activated protein kinase kinase kinase 20 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NYL2-1.


phospholipid phosphatase 4 isoform h3 (human)

A phospholipid phosphatase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5VZY2-3.


protocadherin-17 isoform h2 (human)

A protocadherin-17 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14917-2.


retinoic acid receptor RXR-beta

A protein that is a translation product of the human RXRB gene or a 1:1 ortholog thereof.


vinexin

A protein that is a translation product of the human SORBS3 gene or a 1:1 ortholog thereof.


sodium bicarbonate cotransporter 3 isoform h10 (human)

A sodium bicarbonate cotransporter 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6M7-10.


xanthine dehydrogenase/oxidase

A protein that is a translation product of the human XDH gene or a 1:1 ortholog thereof.


latent-transforming growth factor beta-binding protein 1 O-glycosylated 11 (human)

A latent-transforming growth factor beta-binding protein 1 (human) that has been O-glycosylated at the residue equivalent to Thr-845 of the amino acid sequence represented by UniProtKB:Q14766-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q14766-1, Thr-845, MOD:00005~GNO:G53434XO.


vesicular glutamate transporter 1 isoform h3 (human)

A vesicular glutamate transporter 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9P2U7-3.


chymotrypsin-like elastase family member 1

A trypsin that is a translation product of the human CELA1 gene or a 1:1 ortholog thereof.


alpha-N-acetylgalactosaminidase N-glycosylated 63 (human)

An alpha-N-acetylgalactosaminidase (human) that has been N-glycosylated at the residue equivalent to Asn-201 of the amino acid sequence represented by UniProtKB:P17050-1, in which the glycan structure is represented by GlyTouCan:G86357DX. Example: UniProtKB:P17050-1, Asn-201, MOD:00160~GNO:G86357DX.


A protein that is a translation product of the human PARP9 gene or a 1:1 ortholog thereof.


SUMO-activating enzyme subunit 1 isoform h1 (human)

A SUMO-activating enzyme subunit 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBE0-1.


aggrecan core protein O-glycosylated 9 (human)

An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1856 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1856, MOD:00002~GNO:G43417UB.


hemoglobin subunit theta-1

A hemoglobin subunit that is a translation product of the human HBQ1 gene or a 1:1 ortholog thereof.


bone morphogenetic protein 2 isoform 1, mature form (human)

A bone morphogenetic protein 2 isoform 1, mature form in human. UniProtKB:P12643-1, 283-396.


tissue-type plasminogen activator N-glycosylated 74 (human)

A tissue-type plasminogen activator (human) that has been N-glycosylated at the residue equivalent to Asn-219 of the amino acid sequence represented by UniProtKB:P00750-1, in which the glycan structure is represented by GlyTouCan:G95861KV. Example: UniProtKB:P00750-1, Asn-219, MOD:00160~GNO:G95861KV.


glutamine synthetase

A protein that is a translation product of the human GLUL gene or a 1:1 ortholog thereof.


bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, transit peptide removed form (human)

A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P13995, 36-350.


RNA-binding protein 4

A protein that is a translation product of the human RBM4 gene or a 1:1 ortholog thereof.


sodium/glucose cotransporter 1 isoform h2 (human)

A sodium/glucose cotransporter 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13866-2.


ATP-binding cassette sub-family C member 5

A protein that is a translation product of the human ABCC5 gene or a 1:1 ortholog thereof.


mitochondrial coenzyme A diphosphatase NUDT8 isoform h2 (human)

A mitochondrial coenzyme A diphosphatase NUDT8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WV74-2.


STE20-related kinase adapter protein alpha isoform h2 (human)

A STE20-related kinase adapter protein alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7RTN6-2.


glycine receptor protein

A ligand-gated ion channel protein that is a translation product of the human GLRA1, GLRA2, GLRA3, GLRA4, or GLRB genes, 1:1 orthologs thereof, or a semi-ortholog thereof.


cannabinoid receptor 1 isoform h3 (human)

A cannabinoid receptor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21554-3.


DNA helicase MCM9

A protein that is a translation product of the human MCM9 gene or a 1:1 ortholog thereof.


glial cell line-derived neurotrophic factor isoform h4 (human)

A glial cell line-derived neurotrophic factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P39905-4.


chromodomain-helicase-DNA-binding protein 2 isoform h1 (human)

A chromodomain-helicase-DNA-binding protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14647-1.


tyrosine--tRNA ligase, cytoplasmic isoform 1 (human)

A tyrosine--tRNA ligase, cytoplasmic isoform 1 that is encoded in the genome of human.


CD40 ligand N-glycosylated 4 (human)

A CD40 ligand (human) that has been N-glycosylated at the residue equivalent to Asn-240 of the amino acid sequence represented by UniProtKB:P29965-1, in which the glycan structure is represented by GlyTouCan:G36191CD. Example: UniProtKB:P29965-1, Asn-240, MOD:00160~GNO:G36191CD.


apolipoprotein D N-glycosylated 22 (human)

An apolipoprotein D (human) that has been N-glycosylated at the residue equivalent to Asn-98 of the amino acid sequence represented by UniProtKB:P05090-1, in which the glycan composition is represented by GlyTouCan:G83555HU. Example: UniProtKB:P05090-1, Asn-98, MOD:00160~GNO:G83555HU.


histidine decarboxylase isoform h2 (human)

A histidine decarboxylase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19113-2.


phospholipid scramblase 2 isoform h3 (human)

A phospholipid scramblase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRY7-3.


chondroitin sulfate N-acetylgalactosaminyltransferase 1 O-glycosylated 1 (human)

A chondroitin sulfate N-acetylgalactosaminyltransferase 1 (human) that has been O-glycosylated at the residue equivalent to Ser-101 of the amino acid sequence represented by UniProtKB:Q8TDX6-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q8TDX6-1, Ser-101, MOD:00002~GNO:G43417UB.


phosphatidylinositol 3-kinase regulatory subunit alpha isoform h2 (human)

A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-2.


ATP synthase F(0) complex subunit B1, mitochondrial, transit peptide removed form (human)

An ATP synthase F(0) complex subunit B1, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P24539, 43-256.


calcium/calmodulin-dependent protein kinase type II subunit gamma isoform h9 (human)

A calcium/calmodulin-dependent protein kinase type II subunit gamma (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13555-9.


telomerase reverse transcriptase isoform h4 (human)

A telomerase reverse transcriptase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14746-4.


E3 ubiquitin-protein ligase NEDD4-like isoform h6 (human)

An E3 ubiquitin-protein ligase NEDD4-like (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PU5-6.


3-hydroxyanthranilate 3,4-dioxygenase

A protein that is a translation product of the human HAAO gene or a 1:1 ortholog thereof.


protocadherin-11 X-linked isoform h8 (human)

A protocadherin-11 X-linked (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BZA7-8.


sigma non-opioid intracellular receptor 1 isoform 1 (human)

A sigma non-opioid intracellular receptor 1 isoform 1 that is encoded in the genome of human.


immunoglobulin heavy constant mu N-glycosylated 15 (human)

An immunoglobulin heavy constant mu (human) that has been N-glycosylated at the residue equivalent to Asn-209 of the amino acid sequence represented by UniProtKB:P01871-1, in which the glycan composition is represented by GlyTouCan:G65184UU. Example: UniProtKB:P01871-1, Asn-209, MOD:00160~GNO:G65184UU.


scavenger receptor class B member 1 isoform h3 (human)

A scavenger receptor class B member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WTV0-1.


ectonucleoside triphosphate diphosphohydrolase 2 isoform gamma (human)

An ectonucleoside triphosphate diphosphohydrolase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5L3-3.


DNA-directed DNA/RNA polymerase mu isoform h2 (human)

A DNA-directed DNA/RNA polymerase mu (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NP87-2.


general transcription factor 3C polypeptide 4

A protein that is a translation product of the human GTF3C4 gene or a 1:1 ortholog thereof.


beta-1,3-galactosyltransferase 6

A protein that is a translation product of the human B3GALT6 gene or a 1:1 ortholog thereof.


ceruloplasmin N-glycosylated 58 (human)

A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G06247RL.


fibroblast growth factor 23, signal peptide removed form (human)

A fibroblast growth factor 23, signal peptide removed form in human. UniProtKB:Q9GZV9, 25-251.


fibulin-2 O-glycosylated 4 (human)

A fibulin-2 (human) that has been O-glycosylated at the residue equivalent to Ser-348 of the amino acid sequence represented by UniProtKB:P98095-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P98095-1, Ser-348, MOD:00002~GNO:G43417UB.


monocarboxylate transporter 3

A protein that is a translation product of the human SLC16A8 gene or a 1:1 ortholog thereof.


immunoglobulin heavy constant mu N-glycosylated 101 (human)

An immunoglobulin heavy constant mu (human) that has been N-glycosylated at the residue equivalent to Asn-46 of the amino acid sequence represented by UniProtKB:P01871-1, in which the glycan structure is represented by GlyTouCan:G22674CI. Example: UniProtKB:P01871-1, Asn-46, MOD:00160~GNO:G22674CI.


nuclear factor of activated T-cells, cytoplasmic 3 isoform h6 (human)

A nuclear factor of activated T-cells, cytoplasmic 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12968-6.


mRNA decay activator protein ZFP36 phosphorylated 1 (human)

An mRNA decay activator protein ZFP36 (human) that has been post-translationally modified to include phosphoserine at positions 60 and 186 of the amino acid sequence represented by UniProtKB:P26651. UniProtKB:P26651, Ser-60/Ser-186, MOD:00046.


serum amyloid P-component

A protein that is a translation product of the human APCS gene or a 1:1 ortholog thereof.


myotonin-protein kinase

A protein that is a translation product of the human DMPK gene or a 1:1 ortholog thereof.


tyrosine-protein kinase Fes/Fps

A protein that is a translation product of the human FES gene or a 1:1 ortholog thereof.


serine/threonine-protein kinase RIO1

A protein that is a translation product of the human RIOK1 gene or a 1:1 ortholog thereof.


nociceptin receptor isoform h1 (human)

A nociceptin receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41146-1.


hydroxymethylglutaryl-CoA lyase, mitochondrial isoform h3 (human)

A hydroxymethylglutaryl-CoA lyase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35914-3.


lateral signaling target protein 2 homolog isoform h8 (human)

A lateral signaling target protein 2 homolog (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCC9-8.


hematopoietic cell signal transducer, signal peptide removed form (human)

A hematopoietic cell signal transducer (human) that has had the signal peptide removed. UniProtKB:Q9UBK5, 19-93.


sodium- and chloride-dependent GABA transporter 3

A protein that is a translation product of the human SLC6A11 gene or a 1:1 ortholog thereof.


transient receptor potential cation channel TRPM8

A transient receptor potential channel protein that is a translation product of the human TRPM8 gene or a 1:1 ortholog thereof. TRPM8 is a member of the subfamily M of the transient receptor potential cation channels (TRPs). In common with other TRPs, these proteins have amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity.TRPM8 forms a nonselective cation channel that is activated by cold and by menthol and other substances that produce the sensation of coolness. These channels exhibit voltage-dependance and regulation by phosphatidylinositol-4,5-bisphosphate (PIP2).


E3 ubiquitin-protein ligase MARCHF7

A protein that is a translation product of the human MARCHF7 gene or a 1:1 ortholog thereof.


endothelin-converting enzyme 1 isoform D (human)

An endothelin-converting enzyme 1 isoform 4 that is encoded in the genome of human.


A protein that is a translation product of the human IPO8 gene or a 1:1 ortholog thereof.


dapper homolog 2 isoform h3 (human)

A dapper homolog 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5SW24-3.


cyclin-dependent kinase 4 inhibitor B

A cyclin-dependent kinase inhibitor that is a translation product of the human CDKN2B gene or a 1:1 ortholog thereof.


transcription factor PML isoform 3 (human)

A transcription factor PML isoform 3 that is encoded in the genome of human.


secernin-1 isoform h2 (human)

A secernin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12765-2.


voltage-gated calcium channel protein

A voltage-gated ion channel protein that has voltage-gated calcium channel activity. A voltage-gated calcium channel enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


cytosolic acyl coenzyme A thioester hydrolase

A protein that is a translation product of the human ACOT7 gene or a 1:1 ortholog thereof.


alpha-N-acetylgalactosaminidase N-glycosylated 99 (human)

An alpha-N-acetylgalactosaminidase (human) that has been N-glycosylated at the residue equivalent to Asn-385 of the amino acid sequence represented by UniProtKB:P17050-1, in which the glycan structure is represented by GlyTouCan:G66129DI. Example: UniProtKB:P17050-1, Asn-385, MOD:00160~GNO:G66129DI.


cytosolic 5'-nucleotidase 3A isoform h4 (human)

A cytosolic 5'-nucleotidase 3A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H0P0-3.


branched-chain-amino-acid aminotransferase, cytosolic isoform h3 (human)

A branched-chain-amino-acid aminotransferase, cytosolic (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54687-3.


protein phosphatase PTC7

A protein that is a translation product of the human PPTC7 gene or a 1:1 ortholog thereof.


60 kDa lysophospholipase isoform h3 (human)

A 60 kDa lysophospholipase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86U10-3.


alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform h2 (human)

An alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3V5L5-2.


putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform h2 (human)

A putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NP73-2.


prolyl hydroxylase EGLN2

A protein that is a translation product of the human EGLN2 gene or a 1:1 ortholog thereof.


serum amyloid P-component O-glycosylated 1 (human)

A serum amyloid P-component (human) that has been O-glycosylated at the residue equivalent to Thr-195 of the amino acid sequence represented by UniProtKB:P02743-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02743-1, Thr-195, MOD:00005~GNO:G43417UB.


glycogenin-2 isoform Gamma (human)

A glycogenin-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15488-3.


alpha-2-macroglobulin N-glycosylated 17 (human)

An alpha-2-macroglobulin (human) that has been N-glycosylated at the residue equivalent to Asn-410 of the amino acid sequence represented by UniProtKB:P01023-1, in which the glycan composition is represented by GlyTouCan:G37399XV. Example: UniProtKB:P01023-1, Asn-410, MOD:00160~GNO:G37399XV.


voltage-gated potassium channel subunit KCNQ1 sequence variant T391I (human)

A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Ile residue at the position equivalent to Thr-391 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Thr-391, CHEBI:30009.


5'-3' exonuclease PLD3

A protein that is a translation product of the human PLD3 gene or a 1:1 ortholog thereof.


Rab3 GTPase-activating protein catalytic subunit isoform h1 (human)

A Rab3 GTPase-activating protein catalytic subunit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15042-1.


A protein that is a translation product of the human HK3 gene or a 1:1 ortholog thereof.


2-hydroxyacylsphingosine 1-beta-galactosyltransferase, signal peptide removed form (human)

A 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (human) that has had the signal peptide removed. UniProtKB:Q16880, 21-541.


fibrinogen gamma chain N-glycosylated 2 (human)

A fibrinogen gamma chain (human) that has been N-glycosylated at the residue equivalent to Asn-78 of the amino acid sequence represented by UniProtKB:P02679-1, in which the glycan structure is represented by GlyTouCan:G36191CD. Example: UniProtKB:P02679-1, Asn-78, MOD:00160~GNO:G36191CD.


homeobox protein Meis1 isoform h2 (human)

A homeobox protein Meis1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00470-2.


A protein that is a translation product of the human HMGCLL1 gene or a 1:1 ortholog thereof.


estradiol 17-beta-dehydrogenase 11, signal peptide removed form (human)

An estradiol 17-beta-dehydrogenase 11 (human) that has had the signal peptide removed. UniProtKB:Q8NBQ5, 20-300.


AP-2 complex subunit mu phosphorylated 1 (human)

An AP-2 complex subunit mu (human) that has been phosphorylated on the residue at the position equivalent to Thr-156 of the amino acid sequence represented by UniProtKB:Q96CW1. UniProtKB:Q96CW1, Thr-156, MOD:00047.


dual specificity protein phosphatase 15 isoform h2 (human)

A dual specificity protein phosphatase 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H1R2-2.


heparin cofactor 2 N-glycosylated 4 (human)

A heparin cofactor 2 (human) that has been N-glycosylated at the residue equivalent to Asn-49 of the amino acid sequence represented by UniProtKB:P05546-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P05546-1, Asn-49, MOD:00160~GNO:G06247RL.


beta-alanine-activating enzyme isoform h1 (human)

A beta-alanine-activating enzyme (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q4L235-1.


mu-type opioid receptor isoform h11 (human)

A mu-type opioid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35372-11.


importin subunit alpha-1 isoform 1 (human)

An importin subunit alpha-1 isoform 1 that is encoded in the genome of human.


a disintegrin and metalloproteinase with thrombospondin motifs 2 isoform LpNPI (human)

An a disintegrin and metalloproteinase with thrombospondin motifs 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95450-1.


lysosomal alpha-glucosidase N-glycosylated 1 (human)

A lysosomal alpha-glucosidase (human) that has been N-glycosylated at the residue equivalent to Asn-140 of the amino acid sequence represented by UniProtKB:P10253-1, in which the glycan structure is represented by GlyTouCan:G14343MU. Example: UniProtKB:P10253-1, Asn-140, MOD:00160~GNO:G14343MU.


sodium channel protein type 5 subunit alpha isoform h2 (human)

A sodium channel protein type 5 subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14524-2.


inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform h2 (human)

An inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6PFW1-2.


glyceraldehyde-3-phosphate dehydrogenase isoform 1 (human)

A glyceraldehyde-3-phosphate dehydrogenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04406-1.


NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial, transit peptide removed form (human)

An NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P19404, 33-249.


tRNA-dihydrouridine synthase 2-like

A protein that is a translation product of the human DUS2 gene or a 1:1 ortholog thereof.


A protein that is a translation product of the human PAM gene or a 1:1 ortholog thereof.


NADH-cytochrome b5 reductase 3

A protein that is a translation product of the human CYB5R3 gene or a 1:1 ortholog thereof.


1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 phosphorylated 2 (human)

A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human) that has been post-translationally modified to include phosphotyrosine at positions 753, 759, 1197 and 1217 of the amino acid sequence represented by UniProtKB:P16885. UniProtKB:P16885, Tyr-753/Tyr-759/Tyr-1197/Tyr-1217, MOD:00048.


prolyl hydroxylase EGLN2 isoform hp40 (human)

A prolyl hydroxylase EGLN2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96KS0-2.


Stage IVA Ovarian Cancer AJCC v8

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

Stage IVA includes: Any T, Any N, M1a. M1a: Ovarian cancer with pleural effusion with positive cytology. (from AJCC 8th Ed.)


Stage IV Ovarian Cancer AJCC v8

Stage IV includes: Any T, Any N, M1: M1: Distant metastasis, including pleural effusion with positive cytology; liver or splenic parenchymal metastasis; metastasis to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); and transmural involvement of intestine. (from AJCC 8th Ed.)


Stage IVB Ovarian Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Ovarian cancer with liver or splenic parenchymal metastases; metastases to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); transmural involvement of intestine. (from AJCC 8th Ed.)


N-Acetyl-D-hexosamine

Any N-acetylhexosamine in which the hexosamine has D-configuration. The structure provided is an illustrative example of the pyranose form of an N-acetyl-D-hexosamine.


N-Acetyl-D-Galactosamine

The D-enantiomer of N-acetylgalactosamine.


An N-acetyl-D-glucosamine that has alpha-configuration at the anomeric centre.


N-ACETYL-beta-D-GLUCOSAMINE

An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.


N-Acetyl-D-Mannosamine

An N-acetylmannosamine having D-configuration.


Advanced Rectal Squamous Cell Carcinoma

Rectal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Rectal Squamous Cell Carcinoma

Rectal squamous cell carcinoma that has spread from the original site of growth to other anatomic sites.


Locally Advanced Rectal Squamous Cell Carcinoma

Rectal squamous cell carcinoma that has spread to nearby tissues or lymph nodes.


A 3-oxo Delta(4)-steroid that is 3-oxochol-4-en-24-oic acid carrying an additional 7alpha-hydroxy substituent.


7-Oxoglycochenodeoxycholic acid

A bile acid glycine conjugate that is glycolithocholic acid carrying an additional oxo substituent at postion 7.


bile acid taurine conjugate

A bile acid conjugate resulting from the formal condensation of a bile acid with the amino group of taurine.


3alpha,7alpha,15beta-Trihydroxy-5beta-cholane-24-oic acid methyl ester


A 3-oxo-5beta-steroid that is 7-deoxycholic acid in which the hydroxy group at position 3 has undergone formal oxidation to the corresponding ketone.


allo-bile acid

Any member of the class of bile acids having 5alpha-configuration. Usually found in lower vertebrates.


Tauro-beta-muricholic acid

A bile acid taurine conjugate derived from beta-muricholic acid.


A synthetic cholanoid that is a sulfonic acid analogue of chenodeoxycholic acid.


A bile acid glycine conjugate that is glycodeoxycholic acid carrying an additional oxo substituent at position 7.


bile acid glycine conjugate

Amide of a bile acid with glycine.


5beta-cholanic acids

Members of the class of cholanic acids based on a 5beta-cholane skeleton.


A dihydroxy-5beta-cholanic acid with hydroxy groups located at positions 3beta and 6beta.


An oxo-5beta-cholanic acid that is ursodeoxycholic acid carrying an additional oxo substituent at position 12.


An oxo-5beta-cholanic acid in which two oxo substituents are located at positions 3 and 12 together with a hydroxy substituent at position 7beta.


hydroxy-5beta-cholanic acid

Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position.


bile acid conjugate

Any bile acid conjugated to a functional group that gives additional hydrophilicity or charge to the molecule. Molecules used for conjugation are: glycine, taurine (and other amino acids); sulfuric acid (for which the term ''sulfate'' may be used); glucuronic acid (for which the term ''glucuronate'' may be used); glucose and other uncharged sugars; and coenzyme A.


3-Hydroxy-7,12-diketocholanoic acid

A bile acid that is lithocholic acid carrying two additional oxo substituents at positions 7 and 12.


3alpha,7alpha,15alpha-Trihydroxy-5beta-cholane-24-oic acid methyl ester


dihydroxy-5beta-cholanic acid

A hydroxy-5beta-cholanic acid carrying two hydroxy groups at unspecified positions.


A bile acid that is lithocholic acid carrying an additional oxo substituent at position 7.


A bile acid that is 5alpha-cholan-24-oic acid carrying an oxo group at position 3 and a hydroxy group at position 7beta.


A dihydroxy-5beta-cholanic acid that is deoxycholic acid with a double bond at position 6.


Obeticholic acid

A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.


A C27 bile acid that is 5beta-cholest-24-en-26-oic acid substituted by hydroxy groups at positions 3alpha and 7beta.


bile acid

Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration.


A bile acid taurine conjugate derived from 7-oxodeoxycholic acid.


Ethanesulfonic acid, 2-(((3alpha,5beta,7alpha)-3-hydroxy-24-oxo-7-(sulfooxy)cholan-24-yl)amino)-, disodium salt


1beta-Hydroxydeoxycholic acid

A trihydroxy-5beta-cholanic acid in which the three hydroxy groups are located at positions 1beta, 3alpha, and 12alpha.


bile acids

Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration.


dihydroxycholanic acid

Any member of the class of cholanic acids carrying two hydroxy substituents at unspecified positions.


A bile acid taurine conjugate derived from 7-oxolithocholic acid.


Cervical Warty Carcinoma

A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of a warty surface and koilocytotic atypia.


Stage IIIC Ovarian Cancer

Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0). T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis. N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IIIB Ovarian Germ Cell Tumor AJCC v6 and v7

Stage IIIB includes: T3b, N0, M0. T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IIB Ovarian Cancer AJCC v8

Stage IIB includes: T2b, N0, M0. T2b: Ovarian cancer with tumor extension to and/or implants on other pelvic tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIIA Ovarian Cancer AJCC v6 and v7

Stage IIIA includes: T3a, N0, M0.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor). N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Recurrent Malignant Ovarian Brenner Tumor

The reemergence of malignant ovarian Brenner tumor after a period of remission.


Stage IC Ovarian Germ Cell Tumor AJCC v6 and v7

Stage IC includes: (T1c, N0, M0).  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


FIGO Stage IIIA2 Ovarian Cancer

Ovarian cancer with microscopic, extrapelvic (above the brim) peritoneal involvement +/- positive retroperitoneal lymph nodes. (FIGO, 2014)


Ovarian Neuroendocrine Carcinoma

A small cell carcinoma, pulmonary-type or large cell neuroendocrine carcinoma arising from the ovary.


Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis (excludes peritoneal metastasis). (AJCC 6th and 7th eds.)


Stage IV Ovarian Cancer AJCC v6 and v7

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis (excludes peritoneal metastasis). (AJCC 6th and 7th eds.)


Metastatic Ovarian Clear Cell Adenocarcinoma

Ovarian clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


Stage IIB Ovarian Germ Cell Tumor AJCC v6 and v7

Stage IIB includes: T2b N0, M0. T2b: Extension and/or implants on other pelvic tissues. No malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


FIGO Stage IVA Ovarian Cancer

Ovarian cancer with pleural effusion with positive cytology. (FIGO, 2014)


Recurrent Ovarian Transitional Cell Carcinoma

The reemergence of ovarian transitional cell carcinoma after a period of remission.


Stage IIIC Ovarian Cancer AJCC v8

Stage IIIC includes: T3c, N0/N1, M0. T3c: Ovarian cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Ovarian Mixed Cell Adenocarcinoma

An adenocarcinoma that arises from the ovary and is characterized by the presence of two or more adenocarcinoma components, most often endometrioid and clear cell.


Locally Advanced Ovarian Carcinoma

Ovarian carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Recurrent Ovarian Undifferentiated Carcinoma

The reemergence of ovarian undifferentiated carcinoma after a period of remission.


Metastatic Ovarian Carcinosarcoma

Ovarian carcinosarcoma that has spread from its original site of growth to another anatomic site.


Stage I Ovarian Germ Cell Tumor AJCC v6 and v7

Stage I includes: (T1, N0, M0). T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


malignant sex cord stromal tumor of ovary

Malignant sex cord stromal tumor (SCST) of ovary is a rare ovarian cancer arising from granulosa, theca, sertoli and leydig cells or stromal fibroblasts, occurring at any age and presenting with abdominal or pelvic mass, and characterized (with the exception of fibroma) by the production of sex steroids resulting in manifestations of hormone excess, with a relatively favorable prognosis.


Stage IIIB Ovarian Cancer AJCC v8

Stage IIIB includes: T3b, N0/N1, M0. T3b: Ovarian cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Refractory Ovarian Clear Cell Adenocarcinoma

Ovarian clear cell adenocarcinoma that is resistant to treatment.


Stage IIA Ovarian Cancer AJCC V6 and v7

Stage IIA includes: T2a, N0, M0.  T2a: Extension and/or implants on uterus and/or tube(s). No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


non-gestational ovarian choriocarcinoma

A malignant germ cell tumor that arises from the ovary and is composed of cytotrophoblasts, syncytiotrophoblasts, and extravillous trophoblasts. The prognosis is less favorable than gestational choriocarcinoma.


Stage IB Ovarian Germ Cell Tumor AJCC v6 and v7

Stage IB includes: (T1b, N0, M0). T1b: Tumor limited to both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


FIGO Stage IIIA1(i) Ovarian Cancer

Ovarian cancer with positive retroperitoneal lymph nodes only. Metastasis equal or less than 10 mm. (FIGO, 2014)


malignant non-dysgerminomatous germ cell tumor of ovary

A malignant germ cell tumor other than dysgerminoma that arises from the ovary.


Malignant Ovarian Luteinized Thecoma

A thecoma of the ovary that contains lutein cells and may metastasize to other anatomic sites. It is usually characterized by nuclear atypia and mitotic activity.


ovarian angiosarcoma

A malignant vascular neoplasm arising from the ovary.


Stage II Ovarian Polyembryoma AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor involves one or both ovaries with pelvic extension and/or implants. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IIIA Ovarian Germ Cell Tumor AJCC v6 and v7

Stage IIIA includes: T3a, N0, M0. T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Recurrent Ovarian Carcinosarcoma

The reemergence of ovarian carcinosarcoma after a period of remission.


Ovarian germ cell choriocarcinoma stage II


Recurrent BRCA- Associated Ovarian Carcinoma

The reemergence of BRCA-associated ovarian carcinoma after a period of remission.


Stage IIIB Ovarian Cancer AJCC v6 and v7

Stage IIIB includes: T3b, N0, M0.  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Refractory Extrarenal Rhabdoid Tumor of the Ovary

An extrarenal rhabdoid tumor of the ovary that is resistant to treatment.


Refractory Ovarian Squamous Cell Carcinoma

Ovarian squamous cell carcinoma that is resistant to treatment.


ovarian adenosarcoma

A biphasic neoplasm that arises from the ovary and is characterized by the presence of mullerian-type epithelial tissue in a mesenchymal sarcomatous stroma. The presence of a high grade sarcomatous component is associated with recurrences and metastases.


Stage IV Ovarian Polyembryoma AJCC v6 and v7

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis (excludes peritoneal metastasis). (AJCC 6th and 7th eds.)


Ovarian germ cell choriocarcinoma stage I

Stage I includes: T1, N0, M0. T1: Tumor limited to ovaries (one or both). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor

A Sertoli-Leydig tumor of the ovary characterized by the presence of a sarcomatoid stroma which contains primitive gonadal stromal cells. It may behave in a malignant fashion and metastasize to other anatomic sites.


Malignant Ovarian Thecoma

A thecoma of the ovary which may metastasize to another anatomic site. It is usually characterized by nuclear atypia and mitotic activity. Malignant thecomas are rare.


Ovarian Cancer by AJCC v8 Stage

A term that refers to the staging of ovarian cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to ovarian carcinomas. Nonepithelial primary ovarian cancers may be staged using this classification but should be reported separately. (from AJCC 8th Ed.)


Stage I Ovarian Dysgerminoma AJCC v6 and v7

Stage I includes: (T1, N0, M0). T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Recurrent Ovarian Adenocarcinoma

The reemergence of ovarian adenocarcinoma after a period of remission.


Ovarian Low Grade Endometrioid Stromal Sarcoma

A rare invasive mesenchymal tumor that arises from the ovary.  It is characterized by the absence of marked pleomorphism and nuclear atypia in the neoplastic mesenchymal cells.  It may have a favorable clinical outcome.


Ovarian Mesonephric-Like Adenocarcinoma

An exceedingly rare adenocarcinoma that arises from the ovary and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Recurrent Malignant Ovarian Granulosa Cell Tumor

The reemergence of malignant ovarian granulosa cell tumor after a period of remission.


Refractory Ovarian Transitional Cell Carcinoma

Ovarian transitional cell carcinoma that is resistant to treatment.


Stage I Ovarian Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0. T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Ovarian cancer stage III

Stage III includes: T3, N0, M0.  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IIA Ovarian Germ Cell Tumor AJCC v6 and v7

Stage IIA includes: T2a, N0, M0. T2a: Extension and/or implants on uterus and/or tube(s). No malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


FIGO Stage IC1 Ovarian Cancer

Stage IC ovarian cancer with surgical spill. (FIGO, 2014)


ovarian primitive germ cell tumor

A malignant tumor that arises from the ovary and is characterized by the presence of malignant germ cell components but lacks a teratoma component.


Ovarian Cancer by FIGO Stage

A category of staging terms for ovarian cancer according to the International Federation of Gynecology and Obstetrics (FIGO), 2014. AJCC ovarian cancer stage terms from the 6th and 7th editions that are synonymous to the FIGO ovarian cancer staging classification of 2014 are included as preferred terms.


Metastatic Ovarian Endometrioid Adenocarcinoma

Ovarian endometrioid adenocarcinoma that has spread from its original site of growth to another anatomic site.


Platinum-Refractory Ovarian Carcinoma

Ovarian carcinoma that progresses during platinum therapy or within one month of completing the last platinum therapy.


liposarcoma of the ovary

A malignant adipose tissue neoplasm of the ovary.


FIGO Stage IIIC Ovarian Cancer

Ovarian cancer with macroscopic, extrapelvic, peritoneal metastasis greater than 2 cm +/- positive retroperitoneal lymph nodes. Includes extension to capsule of liver/spleen. (FIGO, 2014)


childhood choriocarcinoma of the ovary

A non-gestational choriocarcinoma that arises from the ovary and occurs in children.


Metastatic Ovarian Small Cell Carcinoma, Hypercalcemic Type

A primary small cell carcinoma of the ovary that is associated with hypercalcemia and has metastasized to other anatomic sites.


Stage III Ovarian Polyembryoma AJCC v6 and v7

Stage III includes: T3, N0, M0. T3: Tumor involves one or both both ovaries with microscopically confirmed peritoneal metastasis outside pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Refractory Ovarian Adenocarcinoma

Ovarian adenocarcinoma that is resistant to treatment.


Stage III Ovarian Dysgerminoma AJCC v6 and v7


Microsatellite Stable Ovarian Carcinoma

Ovarian carcinoma characterized by the absence of microsatellite instability.


Stage IC Ovarian Cancer AJCC v6 and v7

Stage IC includes: T1c, N0, M0. T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Refractory Malignant Ovarian Brenner Tumor

Malignant ovarian Brenner tumor that is resistant to treatment.


Stage IIB Ovarian Cancer AJCC v6 and v7

Stage IIB includes: T2b N0, M0.  T2b: Extension and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IB Ovarian Cancer AJCC v6 and v7

Stage IB includes: T1b, N0, M0. T1b: Tumor limited to both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Platinum-Sensitive Ovarian Carcinoma

Ovarian carcinoma that has a documented response to platinum-based chemotherapy.


Unresectable Ovarian Carcinoma

Ovarian carcinoma that is not amenable to surgical resection.


ovarian Wilms tumor

An embryonal neoplasm arising from the ovary with morphologic features resembling Wilms tumor of the kidney. It occurs during the reproductive age and may present as a rapidly growing adnexal mass.


Recurrent Ovarian Cystadenocarcinoma

The reemergence of ovarian cystadenocarcinoma after a period of remission.


Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor involves one or both ovaries with pelvic extension and/or implants. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IA Ovarian Cancer AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Ovarian cancer with tumor limited to one ovary (capsule intact); no malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Childhood Malignant Ovarian Germ Cell Tumor

A malignant germ cell tumor in children arising from the ovary.  It includes the dysgerminoma, yolk sac tumor, choriocarcinoma, embryonal carcinoma and immature teratoma.


Stage I Ovarian Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Ovarian cancer with tumor limited to ovaries (one or both). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIIA Ovarian Cancer AJCC v8

Stage IIIA includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0. T1: Ovarian cancer with tumor limited to ovaries (one or both). T2: Ovarian cancer with tumor involving one or both ovaries with pelvic extension below pelvic brim. T3a: Ovarian cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Malignant Ovarian Steroid Cell Tumor

A steroid tumor of the ovary which has an aggressive clinical course and metastasizes to other anatomic sites. It is usually of large size and is characterized by nuclear atypia, increased mitotic activity, hemorrhage, and necrosis. Sometimes, patients have abdominal metastases at presentation.


Unresectable Ovarian Endometrioid Adenocarcinoma

Ovarian endometrioid adenocarcinoma that is not amenable to surgical resection.


Recurrent ovarian cancer

The reemergence of ovarian carcinoma after a period of remission.


ovarian neuroendocrine neoplasm

An epithelial neoplasm with neuroendocrine differentiation that arises from the ovary. It includes carcinoid tumor, small cell carcinoma pulmonary type, and large cell neuroendocrine carcinoma.


Refractory Ovarian Mucinous Adenocarcinoma

Ovarian mucinous adenocarcinoma that is resistant to treatment.


Ovarian Signet Ring Cell Carcinoma

An extremely rare adenocarcinoma that arises from the ovary. It is characterized by the presence of signet ring malignant epithelial cells.


Recurrent Ovarian Seromucinous Carcinoma

The reemergence of ovarian seromucinous carcinoma after a period of remission.


Stage IIC Ovarian Carcinoma

Stage IIC includes: T2c, N0, M0.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washing.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Recurrent Platinum-Resistant Ovarian Carcinoma

The reemergence of platinum-resistant ovarian carcinoma after a period of remission.


Recurrent Ovarian Germ Cell Tumor

The reemergence of ovarian germ cell tumor after a period of remission.


Stage IA Ovarian Cancer

Stage IA includes: T1a, N0, M0.  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Ovarian Cancer by AJCC v6 and v7 Stage

A category of staging terms for ovarian cancer according to the American Joint Committee on cancer (AJCC) 6th and 7th editions. International Federation of Gynecology and Obstetrics (FIGO) ovarian cancer staging terms prior to 2014 are included in this category if synonymous with the AJCC terms.


Stage II Ovarian Dysgerminoma AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor involves one or both ovaries with pelvic extension and/or implants. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Refractory Ovarian Undifferentiated Carcinoma

Ovarian undifferentiated carcinoma that is resistant to treatment.


Metastatic Ovarian Undifferentiated Carcinoma

Ovarian undifferentiated carcinoma that has spread from its original site of growth to another anatomic site.


Recurrent Ovarian Endometrioid Adenocarcinoma

The reemergence of ovarian endometrioid adenocarcinoma after a period of remission.


Stage IV Ovarian Germ Cell Tumor AJCC v6 and v7

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis (excludes peritoneal metastasis). (AJCC 6th and 7th eds.)


FIGO Stage IC2 Ovarian Cancer

Stage IC ovarian cancer with capsule rupture before surgery or tumor on ovarian surface. (FIGO, 2014)


ovary leiomyosarcoma

An aggressive malignant smooth muscle neoplasm, arising from the ovary. It is characterized by a proliferation of neoplastic spindle cells.


Metastatic Microsatellite Stable Ovarian Carcinoma

Microsatellite stable ovarian carcinoma that has spread from its original site of growth to another anatomic site.


FIGO Stage IC3 Ovarian Cancer

Stage IC ovarian cancer with malignant cells in the ascites or peritoneal washings. (FIGO, 2014)


Stage IV Ovarian Dysgerminoma AJCC v6 and v7


Stage IC Ovarian Cancer AJCC v8

Stage IC includes: T1c, N0, M0. T1c: Ovarian cancer with tumor limited to one or both ovaries, with any of the following: surgical spill, capsule ruptured before surgery or tumor on ovarian surface, or malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IA Ovarian Germ Cell Tumor AJCC v6 and v7

Stage IA includes: (T1a, N0, M0). T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Metastatic Platinum-Resistant Ovarian Carcinoma

Platinum-resistant ovarian carcinoma that has spread from its original site of growth to another anatomic site.


FIGO Stage IVB Ovarian Cancer

Ovarian cancer with hepatic and/or splenic parenchymal metastasis, metastasis to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside of the abdominal cavity). (FIGO, 2014)


Recurrent Ovarian Clear Cell Adenocarcinoma

The reemergence of ovarian clear cell adenocarcinoma after a period of remission.


Metastatic Ovarian Mucinous Adenocarcinoma

Ovarian mucinous adenocarcinoma that has spread from its original site of growth to another anatomic site.


Stage IB Ovarian Cancer AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Ovarian cancer with tumor limited to one or both ovaries (capsules intact); no tumor on ovarian surface; no malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Refractory Ovarian Carcinoma

Ovarian carcinoma that is resistant to treatment.


Stage I Ovarian Polyembryoma AJCC v6 and v7

Stage I includes: (T1, N0, M0). T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


ovarian melanoma

A melanoma (disease) that involves the ovary.


Refractory Ovarian Endometrioid Adenocarcinoma

Ovarian endometrioid adenocarcinoma that is resistant to treatment.


Ovarian Neuroectodermal-Type Tumor

A rare ovarian malignant tumor with neuroectodermal differentiation. It is characterized either by a small round cell proliferation or by neuronal or glial differentiation.


Ovarian epithelial cancer stage II

Stage II includes: T2, N0, M0.  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


malignant germ cell tumor of ovary

Malignant germ cell tumor of ovary is a rare ovarian cancer arising from germ cells in the ovary, frequently unilateral at diagnosis which characteristically presents during adolescence with pelvic mass, fever, vaginal bleeding and acute abdomen.


Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis (excludes peritoneal metastasis). (AJCC 6th and 7th eds.)


Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor, Variant with Heterologous Elements

An ovarian poorly differentiated Sertoli-Leydig cell tumor. It is characterized by the presence of a heterologous component, usually consisting of cartilage, skeletal muscle, or rhabdomyosarcoma.


Stage IIIA2 Ovarian Cancer AJCC v8

Stage IIIA2 includes: T3a, N0/N1, M0. T3a: Ovarian cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7


undifferentiated sarcoma of ovary

An aggressive high grade sarcoma that arises from the ovary.  It is characterized by the presence of marked pleomorphism and nuclear atypia in the neoplastic mesenchymal cells.  The prognosis is poor.


Stage IIIA1 Ovarian Cancer AJCC v8

Stage IIIA1 includes: T1/2, N1, M0. T1: Ovarian cancer with tumor limited to ovaries (one or both). T2: Ovarian cancer with tumor involving one or both ovaries with pelvic extension below pelvic brim. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIC Ovarian Germ Cell Tumor AJCC v6 and v7

Stage IIC includes: T2c, N0, M0. T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washing. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


ovarian sarcoma

A rare, aggressive malignant mesenchymal neoplasm that arises from the ovary. The prognosis is poor.


FIGO Stage III Ovarian Cancer

Ovarian cancer involving 1 or both ovaries with cytologically or histologically confirmed spread to the peritoneum outside the pelvis and/or metastasis to the retroperitoneal lymph nodes. (FIGO, 2014)


FIGO Stage II Ovarian Cancer

Ovarian cancer involving one or both ovaries with pelvic extension (below the pelvic brim) or primary peritoneal cancer. (FIGO, 2014)


Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7


Advanced Ovarian Carcinosarcoma

Ovarian carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Extrarenal Rhabdoid Tumor of the Ovary

The reemergence of extrarenal rhabdoid tumor of the ovary after a period of remission.


Extrarenal Rhabdoid Tumor of the Ovary

An extrarenal rhabdoid tumor affecting the ovary.


Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7

Stage III includes: T3, N0, M0. T3: Tumor involves one or both both ovaries with microscopically confirmed peritoneal metastasis outside pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


adenocarcinofibroma

A carcinoma arising from the ovary. It is characterized by the presence of malignant epithelial cells in a fibrotic stroma. Histologic variants include clear cell, serous, mucinous, and endometrioid adenocarcinofibroma.


Stage II Ovarian Germ Cell Tumor AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor involves one or both ovaries with pelvic extension and/or implants. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Recurrent Ovarian Mucinous Adenocarcinoma

The reemergence of ovarian mucinous adenocarcinoma after a period of remission.


serous adenocarcinofibroma of ovary

A malignant neoplasm of the ovary with an invasive epithelial component and a fibrotic stroma. The epithelial component is characterized by the presence of malignant epithelial cells of serous type, forming glandular, papillary, and solid patterns.


Stage IV Ovarian Carcinoma

A carcinoma that arises from the ovary and has metastasized to another anatomic site.


Ovarian Non-Neoplastic Disorder

A non-neoplastic disorder that affects the ovary.  Representative examples include endometriosis and polycystic ovarian disease.


BRCA-Associated Ovarian Carcinoma

Ovarian carcinoma caused by deleterious germline mutation in a gene of the BRCA family.


Solid Pseudopapillary Neoplasm of the Ovary

An exceedingly rare solid pseudopapillary tumor that occurs in ectopic pancreatic tissue in the ovary.


Ovarian germ cell choriocarcinoma stage III


Stage IIA Ovarian Cancer AJCC v8

Stage IIA includes: T2a, N0, M0. T2a: Ovarian cancer with tumor extension and/or implants on the uterus and/or fallopian tube(s) and/or ovaries. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Unresectable Ovarian Undifferentiated Carcinoma

Ovarian undifferentiated carcinoma that is not amenable to surgical resection.


FIGO Stage IIIA1 Ovarian Cancer

Ovarian cancer with positive retroperitoneal lymph nodes only. (FIGO, 2014)


Platinum-Resistant Ovarian Carcinoma

Ovarian carcinoma that progresses between one and six months of completing the last platinum therapy.


Stage IIIA Ovarian Carcinoma

Ovarian cancer with positive retroperitoneal lymph nodes and/or microscopic metastasis beyond the pelvis. (FIGO, 2014)


Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7


FIGO Stage IIIA1(ii) Ovarian Cancer

Ovarian cancer with positive retroperitoneal lymph nodes only. Metastasis greater than 10 mm. (FIGO, 2014)


Refractory Ovarian Seromucinous Carcinoma

Ovarian seromucinous carcinoma that is resistant to treatment.


Stage II Ovarian Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Ovarian cancer with tumor involving one or both ovaries with pelvic extension below pelvic brim. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


ovarian malignant mesothelioma

A rare malignant mesothelial neoplasm that usually involves both the ovarian surface and the ovarian stroma. In most cases there is bilateral ovarian involvement.


Stage IIIC Ovarian Germ Cell Tumor AJCC v6 and v7

Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0). T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Unresectable Ovarian Mucinous Adenocarcinoma

Ovarian mucinous adenocarcinoma that is not amenable to surgical resection.


choriocarcinoma of ovary

A choriocarcinoma arising from the ovary. When it appears before puberty is of germ cell origin. In children and young adults signs and symptoms include precocious pseudopuberty and vaginal bleeding. Serum human chorionic gonadotropin is elevated. Germ cell derived ovarian choriocarcinoma should be differentiated from primary or metastatic gestational choriocarcinoma affecting the ovary. The prognosis of germ cell derived choriocarcinoma is less favorable and requires more aggressive chemotherapy treatment regimens compared to gestational choriocarcinoma.


Ovarian Dedifferentiated Carcinoma

An aggressive carcinoma arising from the ovary.  Most patients present with advanced disease.  Microscopically, it is characterized by the presence of an undifferentiated carcinomatous component and a second component of either endometrioid carcinoma or, rarely, serous carcinoma.


Stage III Ovarian Germ Cell Tumor AJCC v6 and v7

Stage III includes: T3, N0, M0. T3: Tumor involves one or both both ovaries with microscopically confirmed peritoneal metastasis outside pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage III Ovarian Cancer AJCC v8

Stage III includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0; IIIB: T3b, N0/N1, M0; IIIC: T3c, N0/N1, M0. T1: Ovarian cancer with tumor limited to ovaries (one or both). T2: Ovarian cancer with tumor involving one or both ovaries with pelvic extension below pelvic brim. T3a: Ovarian cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. T3b: Ovarian cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. T3c: Ovarian cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor involves one or both ovaries with pelvic extension and/or implants. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Unresectable Platinum-Resistant Ovarian Carcinoma

Platinum-resistant ovarian carcinoma that is not amenable to surgical resection.


Ovarian germ cell choriocarcinoma stage IV

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis (excludes peritoneal metastasis). (AJCC 6th and 7th eds.)


hydroxynaphthoquinone

Any naphthoquinone in which the naphthaoquinone moiety is substituted by at least one hydroxy group.


Any member of the class of 1,4-naphthoquinones in which the naphthoquinone moiety is substituted by at least one hydroxy group.


glucocorticoid deficiency 4

Any familial glucocorticoid deficiency in which the cause of the disease is a mutation in the NNT gene.


hypersensitivity reaction disease

An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.


Agigenin

An oxaspiro compound that is (25R)-5alpha-spirostan substituted by hydroxy groups at positions 2, 3 and 6 (the 2alpha,3beta,6beta stereoisomer).


Stage IB Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus, measuring more than 5 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


alpha-mannosidosis

Alpha-mannosidosis is an inherited lysosomal storage disorder characterized by immune deficiency, facial and skeletal abnormalities, hearing impairment, and intellectual deficit.


A lysophosphatidylcholine 18:1 in which the acyl group is specified as oleoyl and is located at either position 1 or 2.


amino sulfonic acid

An organosulfonic acid containing one or more amino groups.


L-Cysteic acid

The L-enantiomer of cysteic acid.


disease

A disease is a disposition to undergo pathological processes that exists in an organism because of one or more disorders in that organism.


congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency

Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency is a unique form of congenital adrenal hyperplasia (CAH) characterized by glucocorticoid deficiency, severe sexual ambiguity in both sexes and skeletal (especially craniofacial) malformations.


classic congenital adrenal hyperplasia

A severe form of congenital adrenal hyperplasia characterized by very low or absent activity of an enzyme in the steroidogenic pathway typically presenting early in life, and requiring life-long cortisol replacement.


inflammatory disease

A disease involving a pathogenic inflammatory response in the anatomical structure.


autosomal recessive non-syndromic intellectual disability

Autosomal recessive form of non-syndromic intellectual disability.


ankylosing spondylitis

An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.


PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome


disorder of gluconeogenesis

An inherited metabolic disease that is has its basis in the disruption of gluconeogenesis.


hereditary hemochromatosis

An inherited metabolic disorder characterized by iron accumulation in the tissues.


metachromatic leukodystrophy, adult form


Homocystinuria without methylmalonic aciduria is an inborn error of vitamin B12 (cobalamin) metabolism characterized by megaloblastic anemia, encephalopathy and, sometimes, developmental delay, and associated with homocystinuria and hyperhomocysteinemia. There are three types of homocystinuria without methylmalonic aciduria; cblE, cblG and cblD-variant 1 (cblDv1).


uterine corpus endometrial stromal sarcoma

A uterine corpus sarcoma originating from the endometrial stroma. It is further subdivided into low grade and high grade endometrial stromal sarcoma.


autoimmune disorder of musculoskeletal system

A hypersensitivity reaction type II disease that involves the musculoskeletal system.


combined oxidative phosphorylation deficiency

A mitochondrial oxidative phosphorylation disorder in which multiple mitochondrial respiratory chain complexes.


Pelizaeus-Merzbacher disease, transitional form

The transitional form of Pelizaeus-Merzbacher disease (PMD) is the intermediate form of PMD.


amino acid metabolism disease

A disease that has its basis in the disruption of cellular amino acid metabolic process.


developmental anomaly of metabolic origin


congenital dyserythropoietic anemia

Congenital dyserythropoietic anemia (CDA) is a heterogenous group of hematological disorders of late erythropoiesis and red cell abnormalities that lead to anemia. Five types of CDA are defined: CDA I, CDA II, CDA III, CDA IV and thrombocytopenia with CDA.


de Barsy syndrome

A rare autosomal recessive genetic disorder characterized by facial dysmorphism (down-slanting palpebral fissures, a broad flat nasal bridge and a small mouth) with a progeroid appearance, large and late-closing fontanel, cutis laxa (CL), joint hyperlaxity, athetoid movements and hyperreflexia, pre- and postnatal growth retardation, intellectual deficit and developmental delay, and corneal clouding and cataract.


non-acquired pituitary hormone deficiency


glycerol kinase deficiency, infantile form

Infantile glycerol kinase deficiency (GKD) is a severe form of GKD characterized clinically by poor feeding, failure to thrive, salt-wasting dehydration, vomiting, Addisonian pigmentation, hypotonia, and disorders of consciousness. Some patients have complex GKD associated with adrenal hypoplasia congenita and/or Duchenne muscular dystrophy (DMD) with manifestations including intellectual deficit, dysmorphic facial features, abnormal external genitalia, strabismus, seizures, and progressive lethargy.


glycerol kinase deficiency, adult form

Adult glycerol kinase deficiency (GKD) is an uncommon form of GKD diagnosed fortuitously and characterized by pseudohypertriglyceridemia in otherwise healthy adults.


isolated oxidative phosphorylation complex disorder


homocarnosinosis

Homocarnosinosis is a metabolic defect characterized by progressive spastic diplegia, intellectual deficit and retinitis pigmentosa. This extremely rare disorder has been reported in only one family, namely a woman and three of her children. The latter showed progressive spastic diplegia, mental retardation and retinitis pigmentosa but their mother was symptom free. It is therefore uncertain whether there is a relationship between the biochemical defect and the clinical symptoms. Inheritance in the reported family seems to be autosomal dominant.


human prion disease

Prion diseases are a group of rare transmissible disorders characterized by progressive debilitating neurological manifestations due to spongiform changes with an invariably fatal course. The disorders all involve accumulation of an abnormal prion protein in the central nervous system with no specific immunological response. Sporadic Creutzfeldt-Jakob disease (CJD) is the most frequent form accounting for about 85% of prion disease cases. The other forms of prion disease are genetic (5-15%) and include inherited CJD, fatal familial insomnia (FFI), and Familial Alzheimer-like prion disease. Acquired forms (< 5%) include iatrogenic CJD and variant CJD (vCDJ).


schizophrenia 10

A schizophrenia that has material basis in an autosomal dominant mutation of SCZD10 on chromosome 15q15.


inherited prion disease

An instance of prion disease that is caused by an inherited modification of the individual's genome.


schizophrenia 1

A schizophrenia that has material basis in an autosomal dominant mutation of SCZD1 on chromosome 5q23-q35.


atypical hemolytic-uremic syndrome with anti-factor H antibodies


autoimmune disorder of the nervous system

A disorder characterized by the degeneration of the nervous system due to autoimmunity. Representative examples include multiple sclerosis, Guillain-Barre syndrome, and myasthenia gravis.


juvenile spondyloarthropathy

A group of chronic, inflammatory childhood diseases characterized by arthritis and enthesitis. This disorder can affect the axial skeleton in late childhood or young adulthood.


vitreous body disorder

Any disease affecting the vitreous body of the eye.


Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2


male reproductive organ cancer

A primary or metastatic malignant neoplasm involving the male reproductive system. Representative examples include prostate carcinoma, penile carcinoma, testicular seminoma, and testicular embryonal carcinoma.


classic congenital lipoid adrenal hyperplasia due to STAR deficency


primary lipodystrophy

Primary lipodystrophies represent a heterogeneous group of very rare diseases characterized by a generalized or localized loss of body fat (lipoatrophy).


familial hypercholesterolemia

An inheritable form of hyperlipidemia, in which there are excess lipids in the blood.


reproductive system neoplasm

A benign or malignant, primary or metastatic neoplasm affecting the male and female reproductive system.


Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency is a hereditary disorder of purine metabolism associated with uric acid overproduction and a continuum spectrum of neurological manifestations depending on the degree of the enzyme deficiency.


6q16 deletion syndrome

Deletion 6q16 syndrome is a Prader-Willi like syndrome characterized by obesity, hyperphagia, hypotonia, small hands and feet, eye/vision anomalies, and global developmental delay.


brain infarction

Tissue necrosis in any area of the brain, including the cerebral hemispheres, the cerebellum, and the brain stem. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by hypoxia and hypoglycemia in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.


disorder of phospholipids, sphingolipids and fatty acids biosynthesis


RAB23-related Carpenter syndrome

Any Carpenter syndrome in which the cause of the disease is a mutation in the RAB23 gene.


familial glucocorticoid deficiency

Familial glucocorticoid deficiency (FGD) is a group of primary adrenal insufficiencies characterized clinically by neonatal hyperpigmentation, hypoglycemia, failure to thrive, and recurrent infections, and biochemically by glucocorticoid deficiency without mineralocorticoid deficiency.


glucocorticoid deficiency 3

A variant of familial glucocorticoid deficiency caused by a defect in the steroidogenic acute regulatory protein; it may mimic lipoid congenital adrenal hyperplasia.


premature aging syndrome

Changes in the organism associated with senescence, occurring at an accelerated rate.


disorder of development or morphogenesis

Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development.