Branch Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

An intraductal papillary-mucinous neoplasm of the pancreas that arises in one of the branches of the main pancreatic duct.  It usually has an indolent behavior.


Mixed Type Pancreatic Intraductal Papillary-Mucinous Neoplasm

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

An intraductal papillary-mucinous neoplasm of the pancreas that arises primarily from the main pancreatic duct and extends to the branch ducts.


Pancreatic Intraductal Papillary Mucinous Neoplasm, Oncocytic-Type

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells with abundant eosinophilic granular cytoplasm.


Main Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

An intraductal papillary-mucinous neoplasm of the pancreas that arises from the main pancreatic duct.


Pancreatic Intraductal Papillary Mucinous Neoplasm, Intestinal-Type

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form tall papillae, similar to those that are present in colonic villous adenomas.


biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA.


toluene oxidation via 4-hydroxytoluene

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol).


toluene metabolic process

The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications.


toluene oxidation to catechol

The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2).


toluene oxidation

The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene.


anaerobic toluene metabolic process

The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen.


toluene oxidation via 2-hydroxytoluene

The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol).


toluene oxidation via 3-hydroxytoluene

The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol).


toluene oxidation via toluene-cis-1,2-dihydrodiol

The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol.


toluene catabolic process

The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.


anaerobic toluene catabolic process

The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen.


Advanced Rhabdoid Tumor

Rhabdoid tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Rhabdoid Tumor

A rhabdoid tumor that has spread from the original site of growth to another anatomic site.


negative regulation of amacrine cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation.


regulation of amacrine cell differentiation

Any process that modulates the frequency, rate or extent of amacrine cell differentiation.


positive regulation of amacrine cell differentiation

Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation.


Inferior Anastomotic Vein of the Labbe

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A superficial blood vessel within the brain that drains the temporal lobe.


sialadenoma papilliferum of salivary gland

An uncommon exophytic papillary proliferation that involves mucosal surface epithelium and salivary duct epithelium. It is exceptional among salivary gland neoplasms because it manifests as an exophytic papillary excrescence of the mucosa, rather than as a submucosal or intraglandular mass. It most often affects the hard or soft palate.  It is generally asymptomatic.


Aurachin C

A C-type aurachin that is quinolin-4-one which is substituted by a hydroxy group at positions 1, a methyl group at position 2, and a triprenyl group at position 3.


Elevated Sedimentation Rate

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

A higher than average sedimentation rate in a sample.


Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP+ = 2,4-dichlorobenzoyl-CoA + NADPH.


Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite.


alphaIIb-beta3 integrin-ICAM-4 complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4.


lateral sprouting involved in mammary gland duct morphogenesis

The process in which a branch forms along the side of a mammary duct.


deep circumflex iliac artery

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The deep circumflex iliac artery (or deep iliac circumflex artery) is an artery in the pelvis that travels along the iliac crest of the pelvic bone.


negative regulation of androgen secretion

Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion.


negative regulation of defecation

Any process that stops, prevents or reduces the frequency, rate or extent of defecation.


negative regulation of defecation rhythm

Any process that stops, prevents or reduces the frequency, rate or extent of defecation rhythm.


negative regulation of thyroid-stimulating hormone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion.


negative regulation of ecdysteroid secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid.


negative regulation of substance P secretion

Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion.


negative regulation of corticosterone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion.


negative regulation of histamine secretion by mast cell

Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell.


negative regulation of androstenedione secretion

Any process that stops, prevents or reduces the frequency, rate or extent of androstenedione secretion.


negative regulation of renal sodium excretion by angiotensin

The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time.


negative regulation of testosterone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion.


negative regulation of glutamate secretion, neurotransmission

Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission.


negative regulation of dehydroepiandrosterone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of dehydroepiandrosterone secretion.


negative regulation of estradiol secretion

Any process that stops, prevents or reduces the frequency, rate or extent of estradiol secretion.


negative regulation of bile acid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.


negative regulation of saliva secretion

Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion.


negative regulation of progesterone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion.


negative regulation of activin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell.


negative regulation of growth hormone secretion

Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.


negative regulation of glycine secretion, neurotransmission

Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission.


negative regulation of substance P secretion, neurotransmission

Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion, neurotransmission.


negative regulation of estrogen secretion

Any process that stops, prevents or reduces the frequency, rate or extent of estrogen secretion.


negative regulation of somatostatin secretion

Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


negative regulation of aldosterone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion.


negative regulation of aspartate secretion

Any process that stops, prevents or reduces the frequency, rate or extent of aspartate secretion.


negative regulation of corticotropin-releasing hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell.


negative regulation of calcitonin secretion

Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion.


negative regulation of parathyroid hormone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion.


negative regulation of mineralocorticoid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion.


negative regulation of inhibin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell.


negative regulation of corticotropin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell.


negative regulation of estrone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of estrone secretion.


negative regulation of cortisol secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell.


negative regulation of arachidonic acid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion.


negative regulation of juvenile hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone.


Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H+.


Catalysis of the reaction: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H+ + phosphate.


negative regulation of midbrain dopaminergic neuron differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of midbrain dopaminergic neuron differentiation.


Low Grade Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is low grade.


unsaturated chondroitin disaccharide hydrolase activity

Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate.


Tentorial Tear Related to Birth

Disruption of the tentorium cerebelli incurred during delivery.


catagen

The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced.


anagen

The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair.


exogen

The shedding phase of the hair cycle.


telogen

The resting phase of hair cycle.


1-undecene metabolic process

The chemical reactions and pathways involving 1-undecene.


sphingoid catabolic process

The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.


3-keto-sphinganine metabolic process

The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine.


sphingosine catabolic process

The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.


phytosphingosine metabolic process

The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids.


phytosphingosine biosynthetic process

The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol.


shikimate metabolic process

The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids.


shikimate catabolic process

The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid.


heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide

The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan.


response to meiotic cell cycle checkpoint signaling

A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint.


response to meiotic spindle assembly checkpoint signaling

A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling.


response to meiotic DNA replication checkpoint signaling

A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling.


anaerobic phenylalanine oxidation

The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde.


liver primordium

A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum.


Tubo-ovarian abscess

An abscess involving the distal fallopian tube and ovary. It is caused by pelvic inflammatory disease or other infections.


deep cervical artery

The deep cervical artery (Profunda cervicalis) is an artery of the neck.


Stage II Childhood Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


collagen type X trimer

A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets).


Carsickness

A sensation of discomfort associated with ground travel; symptoms may include nausea, vomiting, dizziness or sweating.


The chemical reactions and pathways resulting in the formation of hercynylselenocysteine.


superior parathyroid gland

Either of two paired parathyroid glands closest to the head.


Refractory Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that does not respond to treatment.


Refractory Head and Neck Squamous Cell Carcinoma

A head and neck squamous cell carcinoma that does not respond to treatment.


Refractory Sinonasal Squamous Cell Carcinoma

Nasal cavity and paranasal sinus squamous cell carcinoma that does not respond to treatment.


Refractory Oral Cavity Squamous Cell Carcinoma

Oral cavity squamous cell carcinoma that does not respond to treatment.


Refractory Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that does not respond to treatment.


Hodgkin's lymphoma of small intestine

A Hodgkin lymphoma that arises from the small intestine.


transcription factor TFIIIE complex

A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins.


Resectable Pancreatic Acinar Cell Carcinoma

Pancreatic acinar cell carcinoma that is amenable to surgical resection.


Pancreas carcinoma resectable

Carcinoma of the pancreas amenable to surgical removal.


Borderline Resectable Pancreatic Adenocarcinoma

A pancreatic adenocarcinoma term that refers to a continuum between resectable and locally advanced unresectable disease.


Pancreatic adenocarcinoma resectable

Pancreatic adenocarcinoma that is amenable to surgical resection.


Resectable Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma amenable to surgical resection.


Resectable Pancreatic Adenosquamous Carcinoma

Pancreatic adenosquamous carcinoma that is amenable to surgical resection.


4-alpha-methyl-delta7-sterol oxidation

A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O.


negative regulation of protein-glutamine gamma-glutamyltransferase activity

Any process that stops, prevents or reduces the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity.


lachrymatory factor synthase activity

Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide.


negative regulation of gamma-delta T cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation.


negative regulation of CD8-positive, alpha-beta T cell proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.


negative regulation of T cell homeostatic proliferation

Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.


negative regulation of NK T cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation.


Stage I Lip and Oral Cavity Cancer AJCC v8

Stage I includes: T1, N0, M0.  T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less depth of invasion (DOI).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


positive regulation of centriole-centriole cohesion

Any process that activates or increases the frequency, rate or extent of centriole-centriole cohesion.


negative regulation of centriole-centriole cohesion

Any process that stops, prevents or reduces the frequency, rate or extent of centriole-centriole cohesion.


negative regulation of age-related resistance

Any process that stops, prevents or reduces the extent of age-related resistance.


cutaneous vein

One of a number of veins in the subcutaneous tissue that empty into deep veins.


Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine.


propanediol catabolic process

The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH.


propanediol metabolic process

The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items.


anaerobic glycerol catabolic process to propane-1,3-diol

The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water.


negative regulation of epithelial cell-cell adhesion involved in epithelium migration

Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration.


regulation of epithelial cell-cell adhesion involved in epithelium migration

Any process that modulates the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration.


positive regulation of epithelial cell-cell adhesion involved in epithelium migration

Any process that activates or increases the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration.


Hemolytic anemia due to disseminated intravascular coagulation


Anemia due to membrane defect

A group of inherited hemolytic anemias caused by erythrocyte membrane defects. This includes hereditary pyropoikilocytosis, hereditary spherocytosis and hereditary elliptocytosis.


Immune Hemolytic Anemia

An acquired anemia resulting from immune-mediated destruction of the red blood cells. Causes include autoimmune disorders, blood transfusions, and drugs.


Anemia, Hemolytic, Acquired

Hemolytic anemia, the cause of which is not present at birth.


Infantile pyknocytosis

A rare, neonatal syndrome characterized by early jaundice that becomes rapidly associated with severe hemolytic anemia. The peripheral blood smear is remarkable for small irregular, contracted red blood cells with hyper-dense spikes (pyknocytes), that progressively increase in number and then spontaneously disappear.


Angiocentric immunoproliferative lesion grade 2

Lymphomatoid granulomatosis characterized by the presence of occasional large lymphoid cells or immunoblasts in a polymorphous background. Necrosis is more commonly seen as compared to grade I lymphomatoid granulomatosis. By in situ hybridization, EBV-positive cells are readily seen.


Central Nervous System Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis that affects the brain, spinal cord, and leptomeninges.


Cutaneous Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis that affects the skin.


Childhood Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis that occurs during childhood.


telomere single strand break repair

Single strand break repair that takes place in a telomere.


nucleosomal methylation activator complex

A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription.


High Grade Anal Canal Intraepithelial Neoplasia

Intraepithelial neoplasia involving the anal canal.  The epithelial cells exhibit moderate dysplasia (grade II intraepithelial neoplasia) or severe dysplasia (grade III intraepithelial neoplasia or carcinoma in situ).


negative regulation of meiotic chromosome separation

Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation.


HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 6

A lipid transport disorder characterized by extremely elevated levels of high density lipoprotein cholesterol (HDL C; HDLC). It is caused by heterozygous mutations in the SCARB1 gene that result in decreased transport of HCL C into the liver by scavenger receptor class B member 1.


posterior cibarial plate morphogenesis

The process in which the anatomical structures of the posterior cibarial plate are generated and organized.


carbonate ester

Any carbonate that is carbonic acid in which the hydrogens have been replaced by organyl groups.


sarcinapterin biosynthetic process

The chemical reactions and pathways resulting in the formation of sarcinapterin.


sarcinapterin metabolic process

The chemical reactions and pathways involving sarcinapterin.


NADPH-cytochrome-c2 reductase activity

Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2.


(s)-Salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has S configuration.


(r)-Salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has R configuration.


alkanesulfonate monooxygenase activity

Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN.


Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O.


4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin].


2-hydroxyisoflavanone synthase activity

Catalysis of the reactions: liquiritigenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase] and (2S)-naringenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase].


licodione synthase activity

Catalysis of the reaction: H+ + liquiritigenin + NADPH + O2 = H2O + licodione + NADP+.


aflatoxin B synthase activity

Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O2 <=> aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2).


alkanal monooxygenase (FMN-linked) activity

Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light.


uvaol dehydrogenase activity

Catalysis of the reaction: uvaol + NADPH + O2 + H+ <=> ursolic aldehyde + NADP + 2 H2O.


7-deoxyloganin 7-hydroxylase activity

Catalysis of the reaction: 7-deoxyloganin + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganin + oxidized [NADPH-hemoprotein reductase].


Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O.


sterol 12-alpha-hydroxylase activity

Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.


nitrilotriacetate monooxygenase activity (FMN-dependent)

Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN.


3-chloro THPH synthase activity

Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O.


2,5-diketocamphane 1,2-monooxygenase

Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O.


pipecolic acid N-hydroxylase

Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O.


Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H+ + NADPH + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP+.


3,5 dichloro-THPH synthase activity

Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O.


very long-chain fatty acid omega-hydroxylase activity

Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. A very long chain fatty acid is a fatty acid with an aliphatic tail of 22 or more carbons.


Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+.


Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O2 = 3,4-dihydroxyphenylacetate + FAD + H+ + H2O.


germacrene A hydroxylase activity

Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase].


Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase].


long-chain fatty acid omega-hydroxylase activity

Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


medium-chain fatty acid omega-hydroxylase activity

Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.


fatty acid omega-hydroxylase activity

Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


7-deoxyloganate 7-hydroxylase activity

Catalysis of the reaction:  7-deoxyloganate + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O +  loganate + oxidized [NADPH-hemoprotein reductase].


isoflavone 2'-hydroxylase activity

Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase].


Golgi cell precursor proliferation

The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


Refractory Neuroblastoma

A neuroblastoma that does not respond to treatment.


Reactive Hyperplasia of the Retinal Pigment Epithelium

A reactive, non-neoplastic hyperplasia of the retinal pigment epithelium.


AGA codon-amino acid adaptor activity

A triplet codon-amino acid adaptor activity that recognizes an AGA codon.


negative regulation of cell proliferation involved in heart valve morphogenesis

Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.


regulation of cell proliferation involved in heart valve morphogenesis

Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.


positive regulation of cell proliferation involved in heart valve morphogenesis

Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.


regulation of mRNA cap binding

Any process that modulates the frequency, rate or extent of mRNA cap binding.


negative regulation of transferrin receptor binding

Any process that stops, prevents or reduces the frequency, rate or extent of transferrin receptor binding.


negative regulation of selenocysteine insertion sequence binding

Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding.


negative regulation of apolipoprotein binding

Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding.


regulation of small GTPase binding

Any process that modulates the frequency, rate or extent of small GTPase binding.


regulation of actin binding

Any process that modulates the frequency, rate or extent of actin binding.


regulation of heparan sulfate proteoglycan binding

Any process that modulates the frequency, rate or extent of heparan sulfate proteoglycan binding.


negative regulation of lipid binding

Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding.


regulation of C-C chemokine binding

Any process that modulates the frequency, rate or extent of C-C chemokine binding.


regulation of polysome binding

Any process that modulates the frequency, rate or extent of polysome binding.


regulation of core promoter binding

Any process that modulates the frequency, rate or extent of core promoter binding.


negative regulation of C-C chemokine binding

Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine binding.


negative regulation of actin binding

Any process that stops, prevents or reduces the frequency, rate or extent of actin binding.


regulation of selenocysteine insertion sequence binding

Any process that modulates the frequency, rate or extent of selenocysteine insertion sequence binding.


negative regulation of chemokine activity

Any process that stops, prevents or reduces the frequency, rate or extent of chemokine activity.


negative regulation of double-stranded telomeric DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of double-stranded telomeric DNA binding.


negative regulation of microtubule binding

Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding.


negative regulation of growth hormone activity

Any process that stops, prevents or reduces the frequency, rate or extent of growth hormone activity.


negative regulation of mRNA cap binding

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cap binding.


negative regulation of core promoter binding

Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding.


regulation of microtubule minus-end binding

Any process that modulates the frequency, rate or extent of microtubule minus-end binding.


negative regulation of collagen binding

Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding.


negative regulation of G-quadruplex DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA binding.


regulation of G-quadruplex DNA binding

Any process that modulates the frequency, rate or extent of G-quadruplex DNA binding.


regulation of single-stranded telomeric DNA binding

Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA.


regulation of chemokine activity

Any process that modulates the frequency, rate or extent of chemokine activity.


negative regulation of RNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding.


regulation of actin filament binding

Any process that modulates the frequency, rate or extent of actin filament binding.


regulation of apolipoprotein binding

Any process that modulates the frequency, rate or extent of apolipoprotein binding.


regulation of triplex DNA binding

Any process that modulates the frequency, rate or extent of triplex DNA binding.


negative regulation of telomeric DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding.


negative regulation of mRNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA binding.


regulation of DNA replication origin binding

Any process that modulates the frequency, rate or extent of DNA replication origin binding.


negative regulation of euchromatin binding

Any process that stops, prevents or reduces the frequency, rate or extent of euchromatin binding.


negative regulation of actin filament binding

Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding.


regulation of substance P receptor binding

Any process that modulates the frequency, rate or extent of substance P receptor binding.


negative regulation of DNA replication origin binding

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding.


regulation of heparan sulfate binding

Any process that modulates the frequency, rate or extent of heparan sulfate binding.


regulation of growth hormone activity

Any process that modulates the frequency, rate or extent of growth hormone activity.


negative regulation of small GTPase binding

Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase binding.


regulation of double-stranded telomeric DNA binding

Any process that modulates the frequency, rate or extent of double-stranded telomeric DNA binding.


negative regulation of heparan sulfate binding

Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate binding.


negative regulation of polysome binding

Any process that stops, prevents or reduces the frequency, rate or extent of polysome binding.


regulation of euchromatin binding

Any process that modulates the frequency, rate or extent of euchromatin binding.


regulation of lipid binding

Any process that modulates the frequency, rate or extent of lipid binding.


regulation of mRNA 3'-UTR binding

Any process that modulates the frequency, rate or extent of mRNA 3'-UTR binding.


regulation of guanyl-nucleotide exchange factor activity

Any process that modulates the frequency, rate or extent of guanyl-nucleotide exchange factor activity.


negative regulation of mRNA 3'-UTR binding

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-UTR binding.


modulation by host of RNA binding by virus

A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA.


regulation of recombination hotspot binding

Any process that modulates the frequency, rate or extent of recombination hotspot binding.


negative regulation of ferrous iron binding

Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron binding.


negative regulation of heparan sulfate proteoglycan binding

Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate proteoglycan binding.


regulation of RNA polymerase I regulatory region sequence-specific DNA binding

Any process that modulates the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding.


negative regulation of microtubule plus-end binding

Any process that stops, prevents or reduces the frequency, rate or extent of microtubule plus-end binding.


regulation of low-density lipoprotein particle receptor binding

Any process that modulates the frequency, rate or extent of low-density lipoprotein particle receptor binding.


regulation of RNA binding

Any process that modulates the frequency, rate or extent of RNA binding.


negative regulation of triplex DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of triplex DNA binding.


negative regulation of GTP binding

Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding.


negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding.


dishabituation

The temporary recovery of response to a stimulus when a novel stimulus is added.


geranylfarnesyl diphosphate synthase activity

Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate.


D-allose biosynthetic process

The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose.


3,8-divinyl protochlorophyllide a 8-vinyl reductase activity

Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+.


Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H+ + UDP-N-acetyl-D-galactosamine 4,6-disulfate.


Iris Implantation Cyst

A cyst that arises from the iris and is lined by squamous epithelium.


CD8-positive, alpha-beta cytotoxic T cell extravasation

The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue.


CD8-positive, alpha-beta T cell extravasation

The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue.


T-helper 1 cell extravasation

The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.


T-helper 17 cell extravasation

The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue.


site of DNA damage

A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


cellular response to streptomycin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome.


ABC-type quaternary ammonium compound transporting activity

Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in).


ABC-type glycine betaine transporter activity

Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out).


glycine betaine:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in).


quaternary ammonium group:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in).


(R)-carnitine transmembrane transporter activity

Enables the transfer of (R)-carnitine from one side of a membrane to the other.


acyl carnitine transmembrane transporter activity

Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane.


glycine betaine:sodium:chloride symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in).


ATPase-coupled hydroxyectoine transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out).


N-methylnicotinate transmembrane transporter activity

Enables the transfer of N-methylnicotinate from one side of a membrane to the other.


4-(trimethylammonio)butanoate transmembrane transporter activity

Enables the transfer of 4-(trimethylammonio)butanoate from one side of a membrane to the other.


oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen.


carbonyl sulfide nitrogenase activity

Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide.


glucosylceramide biosynthetic process

The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.


deep auricular artery

The deep auricular artery often arises in common with the anterior tympanic artery. It ascends in the substance of the parotid gland, behind the temporomandibular articulation, pierces the cartilaginous or bony wall of the external acoustic meatus, and supplies its cuticular lining and the outer surface of the tympanic membrane. It gives a branch to the temporomandibular joint.


negative regulation of chaperone-mediated protein folding

Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding.


Excessive Bleeding

Abnormally heavy or prolonged loss of blood.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in).


low-affinity sulfate:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.


high-affinity sulfate:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


high-affinity sulfate transmembrane transporter activity

Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations.


cobinamide phosphate guanylyltransferase activity

Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate.


peptidoglycan peptide transmembrane transporter activity

Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains.


choloyl-CoA hydrolase activity

Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA.


postsynaptic modulation of chemical synaptic transmission

Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.


adult somatic muscle development

The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure.


larval somatic muscle development

The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.


gentisate 1,2-dioxygenase activity

Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H+.


Adult Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm, occurring in adults.  It is characterized by a proliferation of neoplastic spindle cells.


Penile Leiomyosarcoma

A leiomyosarcoma that occurs in the penis.


Unresectable Leiomyosarcoma

A leiomyosarcoma which is not amenable to surgical resection.


Dedifferentiated Leiomyosarcoma

A pleomorphic leiomyosarcoma that lacks immunohistochemical staining for myogenic markers in the pleomorphic areas.


Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Pancreatic Leiomyosarcoma

A rare leiomyosarcoma that arises from the pancreas.


Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8

Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage I Uterine Corpus Leiomyosarcoma AJCC v8

Stage I includes: T1, N0, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IV Uterine Corpus Leiomyosarcoma AJCC v8

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus leiomyosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Primary leiomyosarcoma

Leiomyosarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


EBV-Related Leiomyosarcoma

Leiomyosarcoma that is caused by Epstein-Barr virus infection.


Inferior Vena Cava Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm, arising from the inferior vena cava.  It is characterized by a proliferation of neoplastic spindle cells.


Metastatic leiomyosarcoma

A leiomyosarcoma that has spread to other anatomic sites.


leiomyosarcoma of appendix

A rare leiomyosarcoma that arises from the appendiceal wall.


Unresectable Soft Tissue Leiomyosarcoma

A soft tissue leiomyosarcoma that is not amenable to surgical resection.


Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8

Stage IVA includes: T4, Any N, M0. T4: Uterine corpus leiomyosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Conjunctival Leiomyosarcoma

A leiomyosarcoma that arises from the conjunctiva.


Seminal Vesicle Leiomyosarcoma

A rare leiomyosarcoma that affects the seminal vesicle.


Stage IB Uterine Corpus Leiomyosarcoma AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Uterine corpus leiomyosarcoma with tumor limited to the uterus, measuring more than 5 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Pleomorphic leiomyosarcoma

A leiomyosarcoma characterized by the presence of poorly differentiated areas with pleomorphic appearance, in addition to areas with typical morphologic features.


Leiomyosarcoma NCI Grade 2

A leiomyosarcoma with less than 15% necrosis.


Refractory Leiomyosarcoma

Leiomyosarcoma that does not respond to treatment.


Leiomyosarcoma of Vessels

An aggressive malignant smooth muscle neoplasm, arising from the walls of the vascular system.  It is characterized by a proliferation of neoplastic spindle cells.


leiomyosarcoma of bladder

A leiomyosarcoma that arises from the bladder. It is the most common type of bladder sarcoma in adults.


Broad Ligament Leiomyosarcoma

A rare leiomyosarcoma that arises from the broad ligament.


Unresectable Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that is not amenable to surgical resection.


Advanced Soft Tissue Leiomyosarcoma

A soft tissue leiomyosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8

Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Uterine Corpus Leiomyosarcoma by AJCC v8 Stage

A term that refers to the staging of uterine corpus leiomyosarcoma according to the American Joint Committee on Cancer, 8th edition.


Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8

Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. T2: Uterine corpus leiomyosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Childhood Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm, occurring in children.  It is characterized by a proliferation of neoplastic spindle cells.


Leiomyosarcoma recurrent

The reemergence of leiomyosarcoma after a period of remission


Locally Recurrent Uterine Corpus Leiomyosarcoma

The reemergence of uterine corpus leiomyosarcoma after a period of remission, at or adjacent to the site of the original tumor.


Stage III Uterine Corpus Leiomyosarcoma AJCC v8

Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. T2: Uterine corpus leiomyosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Thyroid Gland Leiomyosarcoma

A leiomyosarcoma that arises from the thyroid gland.


Metastatic Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that has spread from its original site of growth to another anatomic site.


Locally Advanced Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that has spread to nearby tissues or lymph nodes.


Colorectal Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm that arises from the colon or rectum.  It is characterized by a proliferation of neoplastic spindle cells.


Metastatic Soft Tissue Leiomyosarcoma

A soft tissue leiomyosarcoma that has spread from the original site of growth to another anatomic site.


Sinonasal Leiomyosarcoma

A leiomyosarcoma that arises from the nasal cavity and paranasal sinuses.


Well Differentiated Leiomyosarcoma

Grade I malignant smooth muscle neoplasm.  It is characterized by a proliferation of neoplastic spindle cells.


Stage IA Uterine Corpus Leiomyosarcoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Uterine corpus leiomyosarcoma with tumor limited to the uterus, measuring 5 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Digestive System Leiomyosarcoma

A leiomyosarcoma arising from an anatomic site in the digestive system.


Resectable Leiomyosarcoma

Leiomyosarcoma that is amenable to surgical resection.


Advanced Leiomyosarcoma

A leiomyosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Soft Tissue Leiomyosarcoma

Soft tissue leiomyosarcoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Leiomyosarcoma

A leiomyosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Leiomyosarcoma of Deep Soft Tissue

A rare leiomyosarcoma that arises from the deep soft tissue in the retroperitoneum or abdominal cavity.


phagolysosome assembly involved in apoptotic cell clearance

The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance.


inositol 5-diphosphate pentakisphosphate 5-kinase activity

Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate.


pectoral appendage

Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues.


archipterygial fin

A type of pectoral fin in which the endoskeletal elements have a main axis that runs through the center of the fin. This creates a bilaterally symmetrical fin. (Modified from Kardong 2012).


pectoral fin

Paired fin that is located in the thoracic region of the body.


6-hydroxynicotinate reductase activity

Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin.


Refractory Malignant Soft Tissue Neoplasm

Malignant soft tissue neoplasm that is resistant to treatment.


thiocyanate hydrolase activity

Catalysis of the reaction: H2O + 2 H+ + thiocyanate = carbonyl sulfide + NH4.


Digestive System Solitary Fibrous Tumor

A solitary fibrous tumor arising from an anatomic site in the digestive system, including the esophagus, gallbladder, liver, pancreas, small bowel mesentery, and the serosal surfaces of the stomach and colon.


Skin tumor of smooth muscle origin

A smooth muscle neoplasm occurring in the skin.


Pilar Leiomyoma

A cutaneous leiomyoma arising from the arrector pili muscle.


skeletal muscle tissue of pectoralis major

A portion of skeletal muscle tissue that is part of a pectoralis major [Automatically generated definition].


Proximal Circumflex Artery

The section of the left circumflex coronary artery that arises from the left main coronary artery and extends to the first marginal branch.


Refractory Paraganglioma

A paraganglioma that does not respond to treatment.


Refractory Adrenal Gland Pheochromocytoma

A pheochromocytoma that does not respond to treatment.


Stage IB Uterine Corpus Cancer AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Uterine corpus carcinoma or carcinosarcoma with tumor invading one half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


cyclic-GMP-AMP hydrolase activity

Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP.


interlobular bile duct

The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad.


A member of the class of benzofurans consisting of a 1-benzofuran skeleton and its substituted derivatives thereof.


broad specificity neutral L-amino acid:basic L-amino acid antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out).


Catalysis of the reaction: S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out).


monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential

Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out).


Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out).


amino acid:monoatomic cation antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc.


aspartate:glutamate, proton antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-aspartate(in) + L-glutamate(out) = H+(in) + L-aspartate(out) + L-glutamate(in).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out).


Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out).


Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out).


ATP:inorganic phosphate antiporter activity

Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + inorganic phosphate(in) = ATP(in) + inorganic phosphate(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out).


Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out).


bicarbonate:monoatomic anion antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in).


Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out).


calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + H+(in) = glycine(in) + H+(out).


gamma-aminobutyric acid:proton antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out).


Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out).


Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out).


metal cation:monoatomic cation antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out).


ADP:inorganic phosphate antiporter activity

Enables the transfer of ADP from one side of a membrane to the other according to the reaction: ADP(out) + inorganic phosphate(in) = ADP(in) + inorganic phosphate(out).


monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential

Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.


Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out).


Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out).


urate:monoatomic anion antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out).


glutamate:gamma-aminobutyric acid antiporter activity

Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out).


3-sulfino-L-alanine: proton, glutamate antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-sulfino-L-alanine (cysteinesulfinate) (out) + H+(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H+(out) + L-glutamate(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out).


Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in).


polyspecific organic cation:proton antiporter activity

Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics.


Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out).


calcium:monoatomic cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration

Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration.


orotate:monoatomic anion antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: orotate(out) + anion (in) = orotate (in) + anion (out).


Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out).


calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration

Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances.


Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out).


hydroxybenzoic acid

Any benzoic acid carrying one or more phenolic hydroxy groups on the benzene ring.


monohydroxybenzoic acid

Any hydroxybenzoic acid having a single phenolic hydroxy substituent on the benzene ring.


caudal ganglionic eminence cell proliferation

The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population.


chaperone mediated protein folding independent of cofactor

The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release.


C-X-C chemokine receptor CXCR4 signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.


CXCL12-activated CXCR4 signaling pathway

The series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


blood-inner ear barrier

The function of the group of barriers and transport systems which regulate the transport of various substances from blood to inner ear tissue and maintain the microhomeostasis and functional integrity of the inner ear; the endothelial cells of the inner ear blood capillaries, linked to each other by tight junctions, represent the main component of the blood-inner ear barrier.


somal translocation

The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate.


Beta-Catenin-Activated Inflammatory Hepatocellular Adenoma

Hepatocellular adenoma with features of both beta-catenin-activated hepatocellular adenoma and inflammatory hepatocellular adenoma.


gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body

Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the cytoplasmic side of the mitotic spindle pole body.


gamma-tubulin complex localization to nuclear side of mitotic spindle pole body

Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the nuclear side of the mitotic spindle pole body.


gamma-tubulin complex localization to mitotic spindle pole body

Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body.


adventurous gliding motility

A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime.


right subclavian artery

The subclavian artery that supplies the right pectoral appendage.


skin appendage follicle

An organ subunit in the skin that gives rise to cutaneous appendage.


vibrissa follicle

One of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species.


coat hair follicle

A hair follicle that is part of a coat of hair.


rhombomere 5 formation

The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA.


detection of mechanical stimulus involved in magnetoreception

The series of events involved in magnetoception in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field.


isoleucine catabolic process

The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.


middle lamella

Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells.


Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+.


host cell mitochondrial outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope.


host outer membrane

The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell.


host cell nuclear outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes.


host cell outer membrane

A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell.


host organelle outer membrane

The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope, occurring in a host cell.


Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-.


Refractory Rhabdoid Tumor of the Kidney

A rhabdoid tumor of the kidney that does not respond to treatment.


Recurrent Rhabdoid Tumor of the Kidney

The reemergence of a rhabdoid tumor of the kidney after a period of remission.


BtuCD complex

Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer.


upper leg blood vessel

A blood vessel that is part of a hindlimb stylopod [Automatically generated definition].


nucleus pulposus

The jelly-like substance in the middle of the spinal disc which is a remnant of the notochord.


Gastrointestinal stromal tumor, benign

A gastrointestinal stromal tumor that is characterized by a maximum diameter equal or less than 5 cm (gastric localization), or equal or less than 2 cm (intestinal localization) and no more than 5 mitotic figures per 50 high power fields.


Benign Gastric Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor arising from the stomach.  It is characterized by a maximum diameter equal or less than 5 cm and no more than 5 mitotic figures per 50 high power fields.


euchromatin-nuclear membrane anchor activity

Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization.


chromatin-nuclear membrane anchor activity

Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis.


heterochromatin-nuclear membrane anchor activity

Binding to heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization.


Stage IA Hepatocellular Carcinoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Solitary tumor equal to or less than 2 cm.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage I Hepatocellular Carcinoma AJCC v8

Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0). T1a: Solitary tumor equal to or less than 2 cm.  T1b: Solitary tumor larger than 2 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IB Hepatocellular Carcinoma AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Solitary tumor larger than 2 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


mesovarium

The mesentery that suspends the ovary from the dorsal wall of the coelom[VHOG].


glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity

Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin.


D-galactonate catabolic process

The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.


galactonate metabolic process

The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose.


L-idonate metabolic process

The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose.


D-gluconate catabolic process

The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose.


ketogluconate metabolic process

The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group.


galactonate catabolic process

The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid.


keto-D-gluconate catabolic process

The chemical reactions and pathways resulting in the breakdown of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose.


keto-D-gluconate metabolic process

The chemical reactions and pathways involving keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose.


L-galactonate metabolic process

The chemical reactions and pathways involving L-galactonate, the anion of L-galactonic acid.


ketogluconate catabolic process

The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group.


L-idonate catabolic process

The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose.


L-galactonate catabolic process

The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid.


aldonic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group.


D-galactonate metabolic process

The chemical reactions and pathways involving D-galactonate, the anion of D-galactonic acid.


methylgallate metabolic process

The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid.


methylgallate catabolic process

The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid.


auxin catabolic process

The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth.


indoleacetic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants.


The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase.


Left Posterior Descending Artery

The second posterolateral branch originating from the posterior atrioventricular left circumflex artery in left dominant and mixed circulations.


tRNA wobble base lysidine biosynthesis

The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine.


tRNA wobble cytosine modification

The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.


tRNA wobble base cytosine methylation

The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position.


plasma membrane proton-transporting ATP synthase, catalytic core

The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species.


(R)-limonene 1,2-monooxygenase NADH activity

Catalysis of the reaction: (4R)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4R)-limonene-1,2-epoxide.


(R)-limonene 1,2-monooxygenase activity

Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide.


(R)-limonene 1,2-monooxygenase NADPH activity

Catalysis of the reaction: (4R)-limonene + NADPH + H+ + O2 = NADP+ + H2O + (4R)-limonene-1,2-epoxide.


response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen.


positive regulation of astrocyte chemotaxis

Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis.


inorganic potassium salt

A potassium salt that lacks C-H bonds


potassium salt

Any alkali metal salt having potassium(1+) as the cation.


ventricular septum intermedium development

The progression of the ventricular septum intermedium over time, from its formation to the mature structure.


leucine N-acetyltransferase activity

Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H+.


Breast Myoid Hamartoma

A breast hamartoma characterized by the predominance of a smooth muscle component.


pectic arabinogalactan I metabolic process

The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1,4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I.


rhamnogalacturonan I side chain metabolic process

The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I.


pectic arabinan metabolic process

The chemical reactions and pathways involving pectic arabinan, a polymer with an alpha-(1->5)-linked L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I.


pectic galactan metabolic process

The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I.


citrate (pro-3S)-lyase activity

Catalysis of the reaction: citrate = acetate + oxaloacetate.


pyruvate synthase activity

Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.


Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate.


1-phosphofructokinase activity

Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate.


negative regulation of cellooligosaccharide metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide metabolic process.


regulation of cellooligosaccharide metabolic process

Any process that modulates the frequency, rate or extent of cellooligosaccharide metabolic process.


positive regulation of cellooligosaccharide catabolic process

Any process that activates or increases the frequency, rate or extent of cellooligosaccharide catabolic process.


positive regulation of cellooligosaccharide metabolic process

Any process that activates or increases the frequency, rate or extent of cellooligosaccharide metabolic process.


negative regulation of cellooligosaccharide catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide catabolic process.


regulation of cellooligosaccharide catabolic process

Any process that modulates the frequency, rate or extent of cellooligosaccharide catabolic process.


right eye

An eye that is part of a right side of organism [Automatically generated definition].


oxidative DNA demethylase activity

Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2.


superficial middle cerebral vein

A vein that runs along the fissure of Sylvius to the cavernous sinus on the lateral surface of the brain and connects to the superior sagittal and transverse sinuses.


cell quiescence

A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed.


Colorectal Microvesicular Hyperplastic Polyp

A serrated hyperplastic polyp that arises from the colon and rectum.  It is characterized by the presence of microvacuolated columnar cells that are admixed with small numbers of goblet cells.  There is no evidence of epithelial atypia or dysplasia.


Refractory Visual Pathway Glioma

Visual pathway glioma that is resistant to treatment.


Stage II Gastric Neuroendocrine Tumor AJCC v8

Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).


DNA/DNA annealing activity

An activity that faciliates the formation of a complementary double-stranded DNA molecule.


DNA-(abasic site) binding

Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base.


sequence-specific DNA binding, bending

The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


cytosine/cytosine mispair binding

Binding to a double-stranded DNA region containing a C/C mispair.


O6-alkylguanine-DNA binding

Binding to an O6-alkylguanine adduct in DNA.


RNA polymerase III type 2 promoter sequence-specific DNA binding

Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.


RNA polymerase III type 1 promoter sequence-specific DNA binding

Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.


single-strand break-containing DNA binding

Binding to damaged DNA containing single-strand breaks (SSBs).


adenine/adenine mispair binding

Binding to a double-stranded DNA region containing an A/A mispair.


carbohydrate response element binding

Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes.


single adenine insertion binding

Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine.


topological DNA co-entrapment activity

A DNA binding activity in which a protein complex interacts with more than one DNA duplex to encircle the DNA molecules with a loose fitting ring.


DNA hairpin binding

Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences.


open form four-way junction DNA binding

Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over.


thymine/thymine mispair binding

Binding to a double-stranded DNA region containing a T/T mispair.


replication fork barrier binding

Binding to replication fork barriers, sites that inhibit the progress of replication forks.


chromatin insulator sequence binding

Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription.


C-rich single-stranded DNA binding

Binding to C-rich, single-stranded DNA.


double-stranded/single-stranded junction telomeric DNA binding

Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang.


RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending

Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


DNA-DNA tethering activity

Bridging together two regions of a DNA molecule.


rDNA spacer replication fork barrier binding, bending

The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


guanine/guanine mispair binding

Binding to a double-stranded DNA region containing a G/G mispair.


mitochondrial promoter sequence-specific DNA binding

Binding to a DNA region that controls the transcription of the mitochondrial DNA.


C-rich strand telomeric DNA binding

Binding to C-rich, single-stranded, telomere-associated DNA.


chromatin loop anchoring activity

Bridging together two DNA loop anchors together, maintaining a chromatin loop.


GC-box binding

Binding to a GC-box, a DNA motif with the consensus sequence GGGCGG that is located upstream of the start point of eukaryotic transcription units. The GC-box may occur in multiple copies or in either orientation relative to the transcription start site.


rDNA spacer replication fork barrier binding

Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription.


N-box binding

Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses.


RNA polymerase III hybrid type promoter sequence-specific DNA binding

Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.


promoter-terminator loop anchoring activity

Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop.


non-sequence-specific DNA binding, bending

The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


adenine/guanine mispair binding

Binding to a double-stranded DNA region containing an A/G mispair.


D-loop DNA binding

Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind.


piRNA cluster binding

Binding to piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs).


crossed form four-way junction DNA binding

Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands.


hemi-methylated DNA-binding

Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.


adenine/cytosine mispair binding

Binding to a double-stranded DNA region containing an A/C mispair.


G-rich single-stranded DNA binding

Binding to G-rich, single-stranded DNA.


P-element binding

Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis.


RNA polymerase III type 3 promoter sequence-specific DNA binding

Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.


plastid promoter transcription regulatory region sequence-specific DNA binding

Binding to a DNA region that controls transcription by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.


cytosine/thymine mispair binding

Binding to a double-stranded DNA region containing a C/T mispair.


RNA polymerase III cis-regulatory region sequence-specific DNA binding

Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes.


piRNA dual-strand cluster binding

Binding to dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription.


RNA polymerase I cis-regulatory region sequence-specific DNA binding

Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element).


juvenile hormone response element binding

Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone.


telomeric G-quadruplex DNA binding

Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres.


tDNA binding

Binding to DNA sequences encoding transfer RNA.


piRNA uni-strand cluster binding

Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa.


sequence-specific DNA binding

Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.


left-handed Z-DNA binding

Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags.