stomach non-glandular epithelium

Am epithelium that lines the stomach which lacks glands. In addition to a glandular epithelium, the stomachs of some vertebrates also has a second region characterized by a nonglandular epithelium, devoid of gastric glands.


rumen epithelium

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The rumen epithelium is the tissue which lines the largest of the four fore stomachs in the ruminant animal -cows and sheep. Rumen epithelial cells are important because they are responsible for the absorption of nutrients from the rumen into the blood.


Peripheral Nervous System Infectious Disorder

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

An infectious process affecting the peripheral nerves.


B-Cell Malignant Neoplasm

A clonal lymphoproliferative disorder composed of neoplastic B-cells. It includes B-cell non-Hodgkin lymphomas, B-cell leukemias, and plasma cell myeloma.


Chronic lymphocytic leukemia stage 1

Risk: Intermediate; Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


DS Stage IA Plasma Cell Myeloma

Durie/Salmon stage I plasma cell myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


B Acute Lymphoblastic Leukemia with t(4;11)(q21;23)

A B-cell acute lymphoblastic leukemia associated with t(4;11)(q21;23). This translocation leads to the generation of the fusion gene MLL-AF4.


Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

A B-cell acute leukemia occurring in childhood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


Hypodiploid B Acute Lymphoblastic Leukemia

A B-cell acute leukemia characterized by the presence of lymphoblasts which contain less than 46 chromosomes. It occurs in both children and adults. It has an unfavorable clinical outcome.


Recurrent Chronic Lymphoid Leukemia

The reemergence of chronic lymphocytic leukemia after a period of remission.


Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Chronic lymphocytic leukemia/small lymphocytic lymphoma that does not respond to treatment.


Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

The reemergence of chronic lymphocytic leukemia/small lymphocytic lymphoma after a period of remission.


Refractory B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

B-acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 that is resistant to treatment.


Leptomeningeal myelomatosis

A central nervous system plasma cell myeloma involving the leptomeninges.


Refractory B Acute Lymphoblastic Leukemia

B-acute lymphoblastic leukemia that does not respond to treatment.


Plasma cell myeloma recurrent

The reemergence of plasma cell myeloma after a period of remission.


DS Stage IIIB Plasma Cell Myeloma

Durie/Salmon stage III plasma cell myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


Recurrent Ph-Like Acute Lymphoblastic Leukemia

The reemergence of  Ph-like acute lymphoblastic leukemia after a period of remission.


Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder

A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed B-lymphocytes or plasma cells. The clonal cellular infiltrates fulfill the criteria for a diffuse large B-cell lymphoma, Burkitt lymphoma, or a plasma cell neoplasm.


Extramedullary Disease in Plasma Cell Myeloma Involving the Central Nervous System

Plasma cell myeloma involving the central nervous system. It manifests with single or multiple intraparenchymal lesions and/or leptomeningeal involvement. Patients present with diffuse cerebral dysfunction and nerve paralysis. The prognosis is poor.


Stage A Chronic Lymphocytic Leukemia

Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

Chronic lymphocytic leukemia characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


Refractory B-Cell Prolymphocytic Leukemia

B-cell prolymphocytic leukemia that is resistant to treatment.


Chronic Lymphocytic Leukemia- Binet Staging System

A term that refers to the staging of chronic lymphocytic leukemia according to Binet staging system. This system is in wide use outside the United States.


Chronic lymphocytic leukemia stage 4

Risk: High; Findings: Lymphocytosis and platelets less than 100,000/microliter; Survival (months): 30. (from AJCC 8th Ed.)


Cutaneous B Lymphoblastic Leukemia/Lymphoma

B-lymphoblastic leukemia/lymphoma that arises from the skin.


Stage B Chronic Lymphocytic Leukemia

Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


Plasma Cell Myeloma Post-Transplant Lymphoproliferative Disorder

A lymphoproliferative disorder that develops following an organ transplantation and exhibits plasma cell myeloma features.


Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorder

A plasmacytoma-like hematologic malignancy that arises in a patient with a history of organ transplantation.


Chronic lymphocytic leukemia stage 2

Risk: Intermediate; Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


Adult B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

A B-cell acute leukemia that occurs during adulthood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


RISS Stage I Plasma Cell Myeloma

Serum beta-2-microglobulin less than 3.5 mg/L and serum albumin 3.5 g/dL or more and no high-risk cytogenetics and normal LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


DS Stage IIB Plasma Cell Myeloma

Durie/Salmon stage II plasma cell myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation

A chronic lymphocytic leukemia characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology.


Extramedullary Disease in Plasma Cell Myeloma

Infiltration of organs and soft tissues by malignant (clonal) plasma cells in patients with history of plasma cell myeloma. Skin, liver, lymph nodes, pleura, and central nervous system are the most frequently affected sites.


Sinonasal Plasmacytoma

A plasmacytoma that arises in the sinonasal tract.


DS Stage IIA Plasma Cell Myeloma

Durie/Salmon stage II plasma cell myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


Progressive Hairy Cell Leukemia Initial Treatment

A hairy cell leukemia requiring initial treatment because of the presence of signs of progression.  Signs of progression include cytopenia (especially if symptomatic), increasing splenomegaly, and infectious complications.  Therapy is not necessary if the patients are asymptomatic and the blood counts are maintained in an acceptable range.


Refractory Transformed Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia which has undergone histologic transformation to an aggressive diffuse large B-cell lymphoma (Richter's transformation) and has become resistant to treatment.


Primary cutaneous plasmacytoma

A plasmacytoma that arises in the skin.


Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

Chronic lymphocytic leukemia characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.


Plasma cell myeloma refractory

Plasma cell myeloma that is resistant to treatment.


Testicular Plasmacytoma

A rare plasmacytoma that arises in the testis. At presentation the involvement is usually unilateral.


DS Stage II Plasma Cell Myeloma

Plasma cell myeloma that fits in neither stage I nor stage III.  Estimated myeloma cell mass: 0.6 to 1.2 trillion (1012)/m2 (intermediate burden).  The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL.  Impaired renal function worsens prognosis regardless of stage.  Note that the newer International Staging System defines stage II quite differently: Beta-2-microglobulin less than 3.5 and albumin less than 3.5 or beta-2-microglobulin 3.5 to less than 5.5 (median survival of 44 months).  (PDQ)


Chronic lymphocytic leukemia refractory

Chronic lymphocytic leukemia that is resistant to treatment.


Recurrent B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

The reemergence of B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 after a period of remission.


Extramedullary Disease in Plasma Cell Myeloma Involving the Uterine Corpus

Infiltration of the uterine corpus by malignant (clonal) plasma cells in patients with history of plasma cell myeloma.


Ph-Like Acute Lymphoblastic Leukemia

A leukemia subtype characterized by a gene-expression profile similar to that of BCR-ABL1-positive acute lymphoblastic leukemia, alterations of lymphoid transcription factor genes, and a poor outcome.


Chronic Lymphocytic Leukemia- Modified Rai Staging System

A term that refers to the staging of chronic lymphocytic leukemia according to modified Rai staging system. This system is mainly used in North America.


Chronic lymphocytic leukemia stage 3

Risk: High; Findings: Lymphocytosis and hemoglobin less than 11 g/dL; Survival (months): 30. (from AJCC 8th Ed.)


RISS Stage II Plasma Cell Myeloma

Not stage I or III. (from AJCC 8th Ed.)


Plasma Cell Myeloma by ISS Stage

A header term that refers to the staging of plasma cell myeloma according to the International Staging System.


Recurrent Burkitt Leukemia

The reemergence of Burkitt leukemia after a period of remission.


Plasma Cell Post-Transplant Lymphoproliferative Disorder

A plasma cell neoplasm that arises in a patient with a history of organ transplantation.


Plasma Cell Myeloma by RISS Stage

A staging system for plasma cell myeloma based on the Revised International Staging System (RISS) criteria. This staging system does not apply to smoldering multiple myeloma (no AJCC staging system), monoclonal gammopathy of undetermined significance (no AJCC staging system), and Waldenstrom macroglobulinemia (no AJCC staging system). (from AJCC 8th Ed.)


Adult Burkitt Leukemia

The leukemic counterpart of Burkitt lymphoma occurring in adults.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


ISS Stage II Plasma Cell Myeloma

Plasma cell myeloma with blood levels of beta-2-microglobulin between 3.5 and 5.5 mg/L.


Plasmacytoma anaplastic

A plasmacytoma characterized by the presence of malignant plasma cells with anaplastic features.


Refractory Burkitt Leukemia

Burkitt leukemia resistant to treatment.


Advanced B-Cell Malignant Neoplasm

A B-cell malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Transformed Chronic Lymphocytic Leukemia

The reemergence of chronic lymphocytic leukemia transformed to aggressive diffuse large B-cell lymphoma (Richter's transformation) after a period of remission.


Extramedullary Disease in Plasma Cell Myeloma Involving the Skin

Infiltration of the skin by malignant (clonal) plasma cells in patients with history of plasma cell myeloma.


Stage C Chronic Lymphocytic Leukemia

Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


Cutaneous Chronic Lymphocytic Leukemia

A chronic lymphocytic leukemia that affects the skin.


DS Stage III Plasma Cell Myeloma

Plasma cell myeloma with one or more of the following: 1. Hemoglobin less than 8.5 g/dL. 2. Serum calcium greater than 12.0 mg/dL. 3. More than three lytic bone lesions. 4. High M protein production as shown by: a. IgG greater than 7.0 g/dL. b. IgA greater than 5.0 g/dL. c. Urinary kappa or lamda greater than 12.0 g/24 hours. Estimated myeloma cell mass: greater than 1.2 trillion (1012)/m2 (high burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL. b. Creatinine greater than or equal to 2.0 mg/dL. Serum beta-2-microglobulin has been shown to be a reliable marker for prognosis. Since the great majority of symptomatic myeloma patients are classified as stage III by the Durie/Salmon criteria, this staging system has not proven to be very useful for identifying the patients with intermediate and poor prognosis. Note that the newer International Staging System defines stage III quite differently: Beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months). (PDQ)


DS Stage I Plasma Cell Myeloma

Plasma cell myeloma with all of the following: 1. Hemoglobin greater than 10 g/Dl, 2. Normal serum calcium, 3. Normal bone structure, 4. Low monoclonal (or myeloma) protein (M protein) production as shown by: a. IgG less than 5.0 g/dL, b. IgA less than 3.0 g/dL, c. Urinary kappa or lamda less than 4 g/24 hours. Estimated myeloma cell mass: less than 0.6 trillion (1012)/m2 (low burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note that the newer International Staging System defines stage I quite differently: Beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months). (PDQ)


B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

A precursor B acute lymphoblastic leukemia (B-ALL) which does not have the cytogenetic abnormality t(9;22)(q34;q11.2). Most cases of ALL do not have this translocation.


DS Stage IIIA Plasma Cell Myeloma

Durie/Salmon stage III plasma cell myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


Recurrent B Acute Lymphoblastic Leukemia

The reemergence of B acute lymphoblastic leukemia after a period of remission.


RISS Stage III Plasma Cell Myeloma

Serum beta-2-microglobulin 5.5 mg/L or more and high-risk cytogenetics and/or high LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


Hyperdiploid B Acute Lymphoblastic Leukemia

A B-cell acute leukemia characterized by the presence of lymphoblasts which contain more than 50 and usually less than 66 chromosomes. It is commonly seen in children and rarely in adults. It has a favorable clinical outcome.


B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

The term refers to precursor lymphoid neoplasms which are composed of B-lymphoblasts and characterized by the absence of recurrent genetic abnormalities.


ISS Stage III Plasma Cell Myeloma

Plasma cell myeloma with beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months).  Note that the older Durie/Salmon staging system defines stage III quite differently. (PDQ)


DS Stage IB Plasma Cell Myeloma

Durie/Salmon stage I plasma cell myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


Recurrent B-Cell Prolymphocytic Leukemia

The reemergence of a B-cell prolymphocytic leukemia after a period of remission.


Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma

Histologic transformation of an indolent chronic lymphocytic leukemia to an aggressive diffuse large B-cell lymphoma.


Extramedullary Disease in Plasma Cell Myeloma Involving the Kidney

Infiltration of the kidney by malignant (clonal) plasma cells in patients with history of plasma cell myeloma.


Chronic lymphocytic leukemia stage 0

Risk: Low; Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


Refractory Ph-Like Acute Lymphoblastic Leukemia

Ph-like acute lymphoblastic leukemia that does not respond to treatment.


ISS Stage I Plasma Cell Myeloma

Plasma cell myeloma with beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months).  Note that the older Durie/Salmon staging system defines stage I quite differently. (PDQ)


B-lymphoblastic leukemia lymphoma BCR-ABL1-like

B lymphoblastic leukemia/lymphoma with translocations involving tyrosine kinases, or translocations involving either the cytokine receptor-like factor 2 (CRLF2) or rearrangements leading to truncation and activation of the erythropoietin receptor (EPOR). It is associated with an adverse prognosis.


Plasma Cell Myeloma by DS Stage

A header term that refers to the staging of plasma cell myeloma according to the Durie/Salmon staging system.


Childhood Burkitt Leukemia

The leukemic counterpart of Burkitt lymphoma occurring in children.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


peri-centrosomal recycling endosome

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A recycling endosome that is organized around the microtubule organizing center, close to the nucleus. This is the main recycling endosome of most cells. It receives input from the Golgi as well as recycled molecules from early endosomes.


Penile Undifferentiated Pleomorphic Sarcoma

A rare undifferentiated pleomorphic sarcoma that occurs in the penis.


Non-Neoplastic Vision Disorder

A non-neoplastic disorder that causes a disturbance in normal vision. Representative examples include amblyopia, astigmatism, myopia, and cataracts.


Color Blindness, Inherited

Genetic based difficulty in distinguishing colors.


Optical Illusion

The visual perception of an image that differs from the reality of the image.


Advanced Extracranial Malignant Solid Neoplasm

A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


Ciliary Body Adenocarcinoma

An adenocarcinoma arising from the pigmented or non-pigmented ciliary epithelium.


Stage IIB Uveal Melanoma AJCC v7

Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIA Uveal Melanoma AJCC v7

Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0). T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Metastatic Choroid Melanoma

Choroid melanoma that has spread from its primary site to another anatomic site.


Metastatic Malignant Neoplasm in the Uvea

A malignant neoplasm that has spread to the uvea from another anatomic site.


Uveal Melanocytoma

A subtype of ciliary body, iris, and choroidal nevi. It is intensely pigmented and composed of large, plump, polyhedral cells.


Choroid Spindle Cell Type A Melanoma

A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Uveal Melanoma by Gene Expression Profile


Uveal Spindle Cell Type A Melanoma

A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage III Uveal Melanoma AJCC v7

Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC (T4d-e, N0, M0).  T2c: Ciliary body and choroid: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T2d: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T3b: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement. T3c: Ciliary body and choroid: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T4a: Iris: Tumor with extrascleral extension less than or equal to 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 without ciliary body involvement and extraocular extension.  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Uveal Class 2 Melanoma

Gene expression profiling that classifies uveal melanomas into a high-grade group.


Uveal Class 1a Melanoma

Uveal melanoma with low metastatic risk as defined by gene expression profiling.


Ciliary Body Nevus

A benign nevus that arises from the ciliary body. Only a small percentage of cases progress to ciliary body melanoma.


Stage IIIC Uveal Melanoma AJCC v7

Stage IIIC includes: T4d-e, N0, M0.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Uveal Melanoma

Uveal melanoma that is resistant to treatment.


Choroidal and Ciliary Body Melanoma by AJCC v8 Stage

A term that refers to the staging of choroidal and ciliary body melanoma, following the rules of the TNM AJCC v8 classification system.


Unresectable Uveal Melanoma

Uveal melanoma that is not amenable to surgical resection.


Stage IIB Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Choroid Spindle Cell Type B Melanoma

A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Stage IIIB Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0). T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Uveal Class 1b Melanoma

Uveal melanoma with intermediate metastatic risk as defined by gene expression profiling.


Ciliary Body Spindle Cell Type B Melanoma

A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Stage II Uveal Melanoma AJCC v7

Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Choroidal and Ciliary Body Melanoma AJCC v8

Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC: (T4d-e, N0, M0). T2c: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T2d: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T3b: Tumor size category 3 with ciliary body involvement. T3c: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4a: Tumor size category 4 without ciliary body involvement and extraocular extension. T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Stage I Uveal Melanoma AJCC v7

Stage I includes: T1a, N0, M0.  T1a: Iris: Tumor limited to the iris not more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIA Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Stage I Choroidal and Ciliary Body Melanoma AJCC v8

Stage I includes: T1a, N0, M0. T1a: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 8th ed.)


Stage IV Choroidal and Ciliary Body Melanoma AJCC v8

Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c). N1: Regional lymph node metastasis or discrete tumor deposits in the orbit. M0: No distant metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less. M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm. M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.1 cm or more.  (AJCC 8th ed.)


Ciliary Body Spindle Cell Type A Melanoma

A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage IIIB Uveal Melanoma AJCC v7

Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0).  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Metastatic Uveal Melanoma

Uveal melanoma that has spread from its primary site to another anatomic site.


Iris Mixed Cell Melanoma

A melanoma arising from the iris. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells.


Stage IV Uveal Melanoma AJCC v7

Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c).  N1: Regional lymph node metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less.  M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm.  M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.0 cm or more.  (AJCC 7th ed.)


Benign neoplasm of uveal tract

A non-metastasizing neoplasm that arises from the uvea.


Stage IIIC Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIIC includes: T4d-e, N0, M0. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Metastatic Malignant Neoplasm in the Iris

A malignant neoplasm that has spread to the iris from another anatomic site.


Stage II Choroidal and Ciliary Body Melanoma AJCC v8

Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Uveal Melanoma by AJCC v7 Stage

A term that refers to the staging of uveal melanoma, following the rules of the TNM AJCC v7 classification system.


Uveal Spindle Cell Type B Melanoma

A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Uveal Class 1 Melanoma

Gene expression profiling that classifies uveal melanomas into a low-grade group.


Uveal Nevus

A benign nevus derived from melanocytes of the uveal tract. Only a small percentage of cases progress to uveal melanoma.


Advanced Uveal Melanoma

Uveal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Iris Epithelioid Cell Melanoma

An iris melanoma characterized by the presence of malignant large epithelioid melanocytes.


Metastatic malignant neoplasm to ciliary body

A malignant neoplasm that has spread to the ciliary body from another anatomic site.


Conjunctival keratoacanthomas

A rapidly growing neoplasm that arises from the conjunctiva. It is characterized by a proliferation of squamous cells, acanthosis, keratinization, dysplasia, increased mitotic activity, and a central crater filled with keratinocytes. It is considered a variant of well-differentiated squamous cell carcinoma with distinct clinical behavior.


Conjunctival Spindle Cell Carcinoma

A variant of conjunctival squamous cell carcinoma characterized by the presence of malignant spindle cells and/or pleomorphic cells.


Stage II Fallopian Tube Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Fallopian Tube Cancer AJCC v8

Stage IIA includes: T2a, N0, M0. T2a: Fallopian tube cancer with extension and/or implants on the uterus and/or fallopian tube(s) and/or ovaries. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIB Fallopian Tube Cancer AJCC v8

Stage IIB includes: T2b, N0, M0. T2b: Fallopian tube cancer with tumor extension to and/or implants on other pelvic tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Laryngeal Paraganglioma

An extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to the larynx.  Patients may present with hoarseness and dysphagia.


Finding by Site or System

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A term that refers to the classification of a clinical or laboratory finding according to the anatomic site or system that is involved.


Muscle Weakness Right-Sided

A reduction in the strength of the muscles in the right side of the body.


Congenital urinary tract obstruction

An impediment to the flow of urine along the urinary tract, which is present at birth.


Atrial Couplet by ECG Finding

An electrocardiographic finding in which two premature atrial complexes occur sequentially. (CDISC)


Right Bundle Branch Block by ECG Finding

An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the right ventricle, manifested by a widened initial portion of the QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration greater than or equal to 120 ms.  An RsR' complex is typically present in leads V1 and V2. (CDISC)


AV Block Second Degree Mobitz Type II by ECG Finding


Jejunum obstruction

Blockage of the normal flow of the small intestinal contents in the jejunum.


Fallopian tube obstruction

Blockage of the normal flow of the contents in the fallopian tube.


Gastrointestinal stenosis

A narrowing or stricture within the digestive system.


Carpal Spasm

A spasmodic contraction of the muscles of the hands, especially the wrists, such as during alkalosis or tetany. (ACC/AHA)


New daily persistent headache

A bilateral, unremitting headache of mild to moderate intensity that occurs daily and may be associated with photophobia, phonophobia, or mild nausea.


Perforation of bladder

A rupture in the bladder wall due to traumatic or pathologic processes.


Pregnancy Finding

Symptoms, signs, diagnostic examinations or a test results in a pregnant mother.


AV Block Third Degree by ECG Finding

An electrocardiographic finding of complete failure of atrial electrical impulse conduction to the ventricles. This is manifested on the ECG by disassociation of atrial and ventricular rhythms. The atrial rate must be faster than the ventricular rate. (CDISC)


Hypotonic-hyporesponsive episode

Acute onset of unresponsiveness or diminished level of consciousness, associated with loss of muscle tone and pallor or cyanosis, that occurs within 48 hours after childhood immunizations. It is primarily associated with pertussis-containing vaccines administered to children under two years of age.


Subclavian vein stenosis

Narrowing of the lumen of the subclavian vein.


Obstruction of trachea

Blockage of the lumen of the trachea. Causes include secretions, foreign bodies, and tumors.


Damage of Vaginal Mucosa

Injury to vaginal mucosa.


Caries into Dentin

Tooth decay that extends through the enamel into the dentin layer.


Intrapartum Shock

Severe loss of blood pressure leading to inadequate tissue perfusion after the onset of labor but prior to the delivery of the fetus.


Neurogenic shock (disorder)

Shock resulting from neurogenic vasodilation, which can be produced by cerebral trauma or hemorrhage, spinal cord injury, deep general or spinal anesthesia, or toxic central nervous system depression.


Brachial plexus palsy due to birth trauma

Birth injury to the brachial plexus. It results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm, usually in the first week of life. In the majority of cases there is spontaneous recovery.


Pedal Spasm

A spasmodic contraction of the muscles of the feet, especially the ankles, such as during alkalosis or tetany. (ACC/AHA)


Syncope due to Acquired Heart Lesion

A condition in which syncope occurs due to a disease process of the heart with which the patient was not born. (ACC/AHA)


Superficial injury of cornea

Trauma to the corneal epithelium.


Palsy

Muscle weakness or paralysis of neurologic origin.


Shock, Traumatic

Any shock produced by trauma.


Psychogenic tremor

An involuntary, compulsive, repetitive stereotyped movement.


R Wave Abnormality by ECG Finding

An electrocardiographic finding of an atypical R wave within the QRS complex; it is due to a disturbance in the depolarization mechanism of the ventricular myocardium.


Normal Virilization

The normal development of male secondary sexual characteristics (such as hirsutism, deepening of the voice) in pubertal boys due to testosterone effects.


Dactylitis

Inflammation of the fingers or toes. This may be accompanied by pain and discoloration.


Insulin Coma

A hypoglycemia-induced comatose state resulting from a large dose of exogenous insulin.


Dissecting aortic aneurysm

A dissecting aneurysm formed between the intimal and medial layers of the aortic wall due to a tear in the tunica intima.


Venous Injury

Damage to a vein from traumatic or pathologic processes.


Large Pleural Effusion

A pleural effusion that is typically characterized as more than one liter.


Pregnancy Outcome

Findings observed at the end of a pregnancy.


Maximum ST Segment Depression by ECG Finding

An electrocardiographic finding of the maximum depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Hypotension due to Cardiac Dysfunction

A condition in which there is hypotension because of inadequate pumping function of the heart. (ACC/AHA)


Cerebral cyst

A fluid filled sac within the cerebrum. It is can be congenital, trauma related or secondary to another medical condition for example an infarction.


Intestinal Stoma Obstruction

A blockage of the intestinal stoma.


Injury of gastrointestinal tract

Trauma to the gastrointestinal tract or accessory organs of digestions.


Cyst of thyroid

Abnormal fluid filled sac within the thyroid gland.


Secondary pulmonary hypertension

Pulmonary hypertension that is caused by an underlying condition.


Reproductive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the reproductive system.


Vaginal Perforation

A rupture in the vaginal wall due to traumatic or pathologic processes.


Intraoperative Arterial Injury

Damage to an artery during a surgical procedure.


Pregnancy Status

The pregnancy status of an individual.


High Grade Atrioventricular Block by ECG Finding

An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by two or more consecutive non-conducted P waves. (CDISC)


Ureter Compression

Narrowing of the luminal diameter of one or both ureters due to extrinsic pressure.


COVID-19-Associated Acute Liver Injury

Acute liver injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Foreign body in esophagus

Extraneous material located within the esophagus.


Postpartum Mental or Behavioral Disorder

A maternal mental or behavioral disorder that occurs in the period following the birth of a child and extending up to six weeks after delivery.


Immunodeficiency due to Functional Defects

An indication that an immunodeficiency disorder is caused by the presence of immune cells that are dysfunctional.


Moderate Hepatic Insufficiency

Findings indicating moderate impairment of liver function.


Chronic Maternal Hypertension with Superimposed Preeclampsia

Chronic hypertension in association with preeclampsia.


Reproductive System Hemorrhage

Bleeding originating in the organs and tissue that aid in reproduction.


Cardiovascular injury

Trauma to the heart and/or blood vessels.


Urostomy Obstruction

Blockage of the urostomy.


Esophageal injury

Trauma to the esophagus.


Extreme Preterm Birth

Birth when a fetus is less than 28 weeks gestational age.


Sinus Bradycardia by ECG Finding

An electrocardiographic finding of abnormally slow heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC)


Female Virilization

The development of male secondary sexual characteristics (such as hirsutism, deepening of the voice, or clitoral enlargement) in girls or adult females.


Vaginal obstruction

Congenital or acquired blockage of the vagina.


Anterior segment ischemia

Compromise of blood supply to the anterior segment of the eye.


Burn of esophagus

Thermal or caustic injury to the esophagus.


Spinal Meningeal Cyst

A cerebrospinal fluid-filled pouch or sac-like protrusion of the arachnoid, dura mater, or nerve root sheath which may contain neural tissue.


Eye and Ear Finding

Symptoms, physical examination results, and/or laboratory test results related to the organs of special sense.


Intrapartum Stillbirth

Fetal death greater than or equal to 20 weeks of gestation during labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond.


Visual Halo

Hazy ring around bright lights seen by some patients with refractive error or optical defects, e.g. cataracts, or corneal swelling.


Injury of conjunctiva

Trauma to the conjunctiva of the eye.


Elective Abortion Finding

An abortion performed due to individual choice, in the absence of a harmful medical condition caused by pregnancy.


Leg Injuries

Trauma to the lower extremity, which is confined to the area between the hip and ankle joints.


Craniotabes

Softening of the skull seen in newborns due to incomplete mineralization.


Injury of colon

Trauma to the colon.


Fetal Heart Finding

An observation of the fetal heart that may or may not be abnormal.


Urethral cyst

A cystic lesion located in the urethra.


Pulmonary vein obstruction

Blockage of the lumen of the pulmonary vein.


Testosterone Excess

Abnormally high level of testosterone.


Ureteric Perforation

A rupture in the wall of the ureter due to traumatic or pathologic processes.


Minimum ST Segment Depression by ECG Finding

An electrocardiographic finding of the minimum depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Urinary System Finding

Symptoms, physical examination results, and/or laboratory test results related to the urinary system.


Undesired Nerve Stimulation

Unintended reaction in nervous system caused by electrical stimulation.


Carotenosis Cutis

Orange or yellow discoloration of the skin caused by excessive deposits of carotene.


Anticipatory Vomiting

A situation in which an individual vomits prior to a medical treatment, commonly chemotherapy, as part of a conditioned/learned response after having previously experienced nausea and/or vomiting as a direct result of that same (or a similar) treatment.


COVID-19-Associated Acute Gastrointestinal Tract Injury

Acute gastrointestinal tract injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Visceral Artery Ischemia

Decreased blood supply to the small or large intestine due to narrowing or blockage of a visceral (mesenteric) artery. The ischemia results to the damage of the intestinal tissues. It may be chronic, caused by atherosclerosis or acute, secondary to the formation of a thrombus or embolus in the mesenteric arterial lumen. In chronic ischemia, patients present with abdominal pain manifested in a short time after a meal and weight loss. In acute ischemia, patients present with sudden and acute abdominal pain, nausea and vomiting, and blood in the stool.


Caries Restricted to Enamel

Tooth decay that is restricted to the enamel layer.


Adrenal Cyst

A cyst located in the adrenal gland.


Duodenal hemorrhage

Bleeding originating from the duodenum.


Congenital Neurogenic Bladder

Neurogenic bladder, the cause of which is present at birth.


AV Block Second Degree by ECG Finding

An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles. This is manifest on the ECG by regular P waves which intermittently are not followed by QRS complexes. (CDISC)


Borderline hypertension

Blood pressure in the zone between the highest normal level and the level that is considered hypertensive.


Jacksonian Seizure

A partial motor seizure that begins in a single area of the body and progresses to include other areas on the same side of the body.


Oculocardiac Reflex

Slowing or cessation of the heart rate secondary to traction on the extraocular muscle.


Intervertebral Disc Compression or Protrusion

Degenerative, pathological or traumatic changes in the cartilaginous tissue of the spine leading to unwanted compression or protrusion of the disc.


Ectopic Atrial Rhythm by ECG Finding

An electrocardiographic finding of a regular atrial rhythm with atrial rate of less than 101 beats per minute which does not originate in the sinus node, and which is characterized by P waves whose morphology differs from the P wave morphology during sinus rhythm. (CDISC)


Ventricular Arrhythmia by ECG Finding

An electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles.


Ear Finding

Symptoms, physical examination results, and/or laboratory test results related to the ear.


Alterations in Smell or Taste

A change to taste and/or olfactory perception resulting from disease processes or treatment.


Non-Febrile Seizure

A seizure that is not associated with fever.


Jugular vein injury

Damage to the jugular vein from traumatic or pathologic processes.


Psychosexual dysfunction with inhibited sexual excitement

Recurrent and persistent suppression of sexual excitement during sexual activity.


Impaired Balance

A deficit in equilibrium, which may manifest as unsteady ambulation or inability to maintain an upright position.


Decreased Physical Activity

A reduction in the normal physical activity for an individual.


Cecal Hemorrhage

Bleeding originating in the cecum.


Mean ST Segment Depression by ECG Finding

An electrocardiographic finding of the average depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Arrhythmogenic Syncope

A condition in which syncope occurs due to an arrhythmia. (ACC/AHA)


Intraoperative Ear Injury

Damage to the ear during a surgical procedure.


Arterial Injury

Damage to an artery from traumatic or pathologic processes.


Endocrine System Signs and Symptoms

Patient complaints, physical findings, laboratory findings referable to the endocrinologic system.


Therapeutic Abortion Finding

An abortion performed on the individual due to a harmful medical condition caused by pregnancy.


Drug-induced hypotension

A condition in which there is hypotension because of the effects of a medication or other substance. (ACC/AHA)


Micropsia

An alteration in visual perception that causes objects to appear smaller than their actual size.


Hormone Imbalance

An abnormal finding indicating that the level of a particular hormone is not within the expected normal values.


Syncope due to Congenital Heart Lesion

A condition in which syncope occurs due to a disease process of the heart with which the patient was born. (ACC/AHA)


Headache due to external compression of head

Headache resulting from pressure applied to the cutaneous nerves of the head.


Acoustic Trauma

Injury to the hearing mechanisms within the inner ear, caused by excessively loud noise.


Cyst of pharynx

A cervical cyst that occurs as a result of the persistence of one or more of the pharyngeal grooves.


Intraoperative Renal Injury

Damage to the kidney during a surgical procedure.


Perforation of great vessels

Damage to the venae cavae, pulmonary artery, pulmonary veins or aorta resulting from a full thickness disruption in the integrity of the vessel wall.


Blocked premature atrial contraction

An electrocardiographic finding of premature atrial complexes which are not conducted to the ventricle, and which are not followed by a QRS complex. (CDISC)


Aneurysm, Ruptured

An aneurysm that has burst, resulting in hemorrhage into adjacent tissues.


Malignant Bowel Obstruction

Obstruction of the bowel by an advanced malignant tumor. It is a complication especially in patients with an advanced abdominal malignant tumor.


Ileal hemorrhage

Bleeding originating from the ileal wall.


Atrial bigeminy

An electrocardiographic finding of a sinus beat followed by a premature atrial complexes for three or more consecutive cycles; a regularly irregular rhythm of normal and abnormal P waves in a 1-1 ratio. (CDISC)


Intraoperative Cardiac Injury

Damage to the heart during a surgical procedure.


Incomplete Bundle Branch Block by ECG Finding

An electrocardiographic finding of partially blocked cardiac electrical impulse conduction along the fibers of one or both bundle branches.


Paronychial Inflammation

Swelling and redness of the nail folds.


Umbilical Cord Finding

Clinical and laboratory findings about the umbilical cord.


First Trimester Antepartum Hemorrhage

Excessive blood loss within the first trimester but prior to onset of labor.


Injury of liver with open wound into abdominal cavity

Trauma to the liver associated with a break in the tissue that extends into the abdominal cavity.


Aneurysm, Bacterial

An aneurysm caused by an infection.


Endometrioma

A cystic form of endometriosis affecting the ovary.  It may or may not be associated with endometriosis in other areas in the pelvis.


Marked Sinus Bradycardia by ECG Finding

An electrocardiographic tracing demonstrating sinus bradycardia, with a heart rate lower than an acceptable, predetermined threshold.  Different thresholds, for rate and/or duration, may apply to different patient populations.


Lamellar laceration of the globe

Traumatic injury to the globe, resulting in a partial thickness wound of the eyewall (cornea and/or sclera). (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Cerebrospinal Fluid Otorrhea

Discharge of cerebrospinal fluid through the ear structures.


In-Hospital Cardiac Arrest

Cardiac arrest which occurs in the hospital setting.


Knee Injuries

Trauma to the knee.


Elbow Injuries

Trauma to the elbow joint.


Atrial trigeminy

An electrocardiographic finding of two sinus beats followed by a premature atrial complex for 3 or more consecutive cycles; a regularly irregular rhythm of normal and abnormal P waves in a 2-1 ratio. (CDISC)


Intracranial Colloid Cyst

Colloid cysts i.e. cysts filled with gelatinous material, in the central nervous system often are found in the third ventricle. Due to their location, chronic or intermittent hydrocephalus can result. Case reports of sudden death due to acute obstructive hydrocephalus are in the literature. Colloid cysts are benign lesions that should be considered for neurosurgical resection.


Atrioventricular Nodal Reentry Tachycardia by ECG Finding

An electrocardiographic finding of a regular supraventricular tachycardia due to reentry within the AV node. It is characterized by P waves which typically occur nearly simultaneously with the QRS complex, resulting in a P wave which is obscured by the QRS, merged with the QRS or which may follow the QRS. (CDISC)


Acquired Neurogenic Bladder

Neurogenic bladder, the cause of which is not present at birth.


Migraine-triggered seizure

A seizure triggered by a migraine.


Musculoskeletal Finding

Symptoms, physical examination results, and/or laboratory rest results related to the muscles and bones.


Kidney perforation

A rupture in the kidney due to traumatic or pathologic processes.


Decreased Uncorrected Visual Acuity

Diminished clarity of vision without optical correction (glasses and/or contacts).


Cardiac Arrest/Arrhythmia Etiology Unknown

An episode of cardiac arrest or arrhythmia where the etiology was unknown. (ACC)


Acquired Urinary Tract Obstruction

A urinary tract obstruction, the cause of which is not present at birth.


Adrenal Androgen Excess

Excessive secretion of the androgen hormones dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione, from the adrenal gland. Clinical manifestations may include virilization.


Complicated Parapneumonic Pleural Effusion

An accumulation of fluid in the pleural space adjacent to an infectious pulmonary process, such as a pneumonia or a lung abscess, and that requires therapeutic drainage.


Mitral perforation

A rupture in the mitral valve tissue due to traumatic or pathologic processes.


Male Reproductive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the male reproductive system.


Injury of esophagus without open wound into thoracic cavity

Trauma to the esophagus without indication of associated damage to the skin and other internal and external tissues.


Hemorrhage of prostate

Bleeding originating from the prostate gland.


Fallopian tube perforation

A rupture of the fallopian tube wall due to tubal pregnancy, or other traumatic or pathologic processes.


Postpartum Complication

Any adverse event that arises in the six week period immediately following the delivery of a fetus.


Fetal virilism

Inappropriate secondary sex characteristics in the neonate usually due to in utero androgen exposure.


Gastric Obstruction

Blockage of the normal flow of the contents in the stomach.


Pathologic Laughter

A condition defined by relatively uncontrollable episodes of laughing.


Injury of larynx

Trauma to the larynx.


Injury of anus

Trauma to the anus.


Early Pregnancy Loss

Pregnancy loss before 10th week of gestation with documentation of a confirmed pregnancy.


Endocrine System Finding

Symptoms, physical examination results, and/or laboratory test results related to the endocrine system.


Laceration of the Globe

Full-thickness wound of the eyewall (cornea and/or sclera) caused by a sharp object.


Baseline Fetal Heart Rate

The number of fetal cardiac beats per minute, considered as the reference value against which measurements in the future can be made.


Foreign body in stomach

Extraneous material located within the stomach.


Arteriovenous fistula aneurysm

A bulge in a weakened vessel wall segment of an arteriovenous fistula.


Coma Greater than 24 Hours

An indication that coma has lasted more than 24 hours.


Proximal Left Anterior Descending Coronary Artery Stenosis

A narrowing of the proximal portion of the left main coronary artery, usually considered significant if the stenosis is 70% or greater.


Fine corneal edema

Corneal edema of inflammatory origin associated with contact lens wear and morphologically characterized by presence of epithelial microcysts. Microcysts are small (typically 10-50 microns in diameter), clear, irregularly shaped high refractive inclusions that form in the basal layers of the epithelium and move towards the anterior surface of the cornea, surrounding epithelial haze. The cause of microcytic edema is related to the physical presence of contact lenses and possibly a mechanical effect of lens wear.


Leukoderma

Localized loss of skin pigmentation, often in patches.


Penetrating open globe injury

Full thickness wound of the eyewall (cornea and/or sclera) caused by the entry of a sharp object into the eye. (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Cartilage injury

Trauma to cartilage.


Macropsia

An alteration in visual perception that causes objects to appear larger than their actual size.


Erythema of the Oropharyngeal Mucosa

Erythema of the mucus membranes lining the part of the pharynx located between the soft palate and the upper portion of the epiglottis.


Tracheostomy Site Bleeding

Bleeding from the tracheostomy site.


left main coronary artery stenosis

Percent luminal narrowing of the left main coronary artery, at the point of maximal stenosis of the left main coronary artery.


Eye muscle weakness

A reduction in the strength of the eye muscles.


Urinary Tract Stenosis

An intrinsic narrowing of a lumen of the urinary tract.


Sensory Change

An alteration in the perceptual senses an individual.


Ileal Obstruction

Blockage of the normal flow of the small intestinal contents in the ileum.


Ventricular Tachycardia/Ventricular Fibrillation Arrest

A cardiac arrest attributed to ventricular tachycardia or ventricular fibrillation.


AV Block Second Degree Mobitz Type I by ECG Finding

An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a progressively lengthening PR interval prior to the block of an atrial impulse. (CDISC)


Spinal Injuries

Damage to the spine that results in impaired function.


Familial Male Precocious Puberty

Early development of isosexual secondary characteristics in boys, due to autosomal dominant mutations in the LHCGR gene.


Pigmentary Change in Skin

Abnormal skin pigmentation.


Injury to Superior Vena Cava

Damage to the superior vena cava from traumatic or pathologic processes.


Antepartum Uterine Rupture

An acute symptomatic tearing of the uterine wall prior to the onset of labor.


Carotid Artery Injuries

Damage to the carotid artery. Causes include blunt injuries (e.g., motor vehicle accidents and sports-related injuries) and penetrating traumas (e.g., gunshot and knife injuries).


Dissecting Abdominal Aortic Aneurysm

A dissecting aneurysm in the portion of the descending aortic wall that is within the abdomen.


Chronic peritoneal effusion (disorder)

Persistent or recurring accumulation of fluid in the peritoneal cavity.


Vaginal Discharge

Normal or abnormal secretions from the vagina. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Causes of abnormal vaginal discharge include infectious agents (e.g., Neisseria gonorrhea, Chlamydia trachomatis, Trichomonas, and Candida albicans), the presence of foreign bodies, and cervical or vaginal cancer.


Erb-Duchenne Paralysis

Weakness or paralysis of muscles in the arm due to damage in the upper brachial plexus.


Spontaneous Intestinal Perforation

A focal intestinal perforation without a definite cause, commonly located in the terminal ileum, lacking the transmural inflammation and/or pneumatosis typically seen in necrotizing enterocolitis.


Injury of kidney

Trauma to the kidney.


Cardioinhibitory Syncope

A condition in which neurally-mediated syncope occurs in which the blood pressure falls and heart rate falls. (ACC/AHA)


Zenker Diverticulum

A diverticulum of the posterior pharyngeal wall opening, which is located just posterior the cricoid cartilage, between the inferior pharyngeal constrictor and the cricopharyngeus muscles.


Visual Change

An alteration in the visual system of an individual.


Foot Or Leg Hypoesthesia

Consisting of abnormally decreased sensitivity, particularly to touch in the foot or leg.


Hormone Resistance

A finding indicating decreased tissue sensitivity to a hormone.


Finger Injuries

Trauma to one of the digits on the hand.


Gastrointestinal Adhesion

A fibrous connection of tissue that joins together normally separate gastrointestinal regions.


Urostomy perforation

A perforation in the anatomic parts which are used in the construction of a urostomy.


Heart Block by ECG Finding

An electrocardiographic finding of blocked cardiac electrical impulses along the fibers normally responsible for impulse conduction.


Unilateral Numbness

A loss of the sensation of feeling on one side of the body.


Perforating open globe injury

Open globe injury with both entrance and exit wounds in the eyewall (cornea and/or sclera) caused by the same object.


Cushing Triad

A group of signs that often occurs in response to increased intracranial pressure: hypertension, bradycardia, and irregular breathing.


Flasher

The perception of sudden or brief bursts (flashes) of light.


Hemorrhage of digestive system

Bleeding originating from any part of the digestive system.


Syncope due to Migraine

A condition in which syncope occurs associated with the occurrence of cerebral vasospasm. (ACC/AHA)


Caries, Region Unknown

Tooth decay of an unspecified location.


Malignant ascites

Accumulation of fluid in the peritoneal cavity resulting from the growth of primary or metastatic malignant neoplasms in the peritoneum.


Vasoconstriction

Vasoconstriction involves narrowing of a blood vessel lumen due to smooth muscle contraction in the vessel wall and leads to decreased blood flow.


Connective and Soft Tissue Injury

Damage inflicted on the soft tissues and their supporting structures as the direct or indirect result of an external force, with or without disruption of structural continuity.


Motor Manifestations

The presence of an alteration in the ability to move one's body or any body parts in accordance with one's intent.


Ureterovesical Obstruction

Blockage of the opening between the ureter and the bladder resulting in the reduction or prevention of the urine flow from the ureter to the bladder.


Supraventricular Arrhythmia by ECG Finding

An electrocardiographic finding of an arrhythmia originating in the atrium, AV node or AV junction.


Electrocardiographic Finding

Graphic representation and categorization of the electrical vectors produced by the depolarization and repolarization of myocardial tissue.


Unspecified antepartum hypertension

High blood pressure in the period of time preceding labor and delivery.


Primary Cough Headache

Headache triggered by coughing or straining in the absence of an intracranial disorder.


Digestive System Signs and Symptoms

Signs and symptoms associated with disturbances within the digestive system, which includes the stomach, intestines and all associated organs that aid in digestion.


Intestinal Stoma Site Hemorrhage

A finding of blood leakage from the intestinal stoma.


Conjunctival Ecchymosis

Bleeding between the conjunctiva and episclera in the absence of discharge or inflammation.


Paroxysmal Atrial Fibrillation by ECG Finding

An electrocardiographic tracing demonstrating intermittent atrial fibrillation in the presence of sinus rhythm, junctional rhythm, or an atrial paced rhythm.


Jejunal hemorrhage

Bleeding originating from the jejunal wall.


Recurrent Large Pleural Effusion

The reemergence of a large pleural effusion after a period of remission.


Uncomplicated hypertension

A condition of high blood pressure without resulting clinical disorders.


Cervical Spine Joint Range of Motion Decreased

Decreased flexibility of a cervical spine joint.


Phosphene Visualization

An objective visual sensation that appears with the eyes closed and in the absence of visual light.


Testicular Cyst

A cystic lesion located in the testes.


Valvular stenosis

Narrowing of the opening of one or more of the four valves of the heart.


Inferior vena cava stenosis

Abnormal narrowing of the lumen of the inferior vena cava.


Coronary artery perforation

A dissection that extends through the full thickness of the coronary arterial wall. (ACC)


Page kidney

Hypertension resulting from activation of the renin-angiotensin system in response to prolonged compression of the renal parenchyma and blood vessels.


Decreased Visual Acuity with Current Correction

Diminished clarity of vision with current correction (glasses and/or contacts).


Congenital obstruction of ureteropelvic junction

Complete or partial blockage of the ureter at the point where it enters the kidney that is present at birth.


Phantogeusia

A lingering, usually unpleasant, taste without the associated stimulus.


Breastfeeding Jaundice

Yellow coloring of skin, mucous membranes and eyes in an otherwise healthy breast-fed newborn due to insufficient intake of maternally-expressed milk. It commonly appears four to seven days after birth.


Carcinomatous ascites

Accumulation of fluid in the peritoneal cavity resulting from the growth of primary or metastatic carcinoma in the peritoneum.


Atrial Flutter by ECG Finding

An electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth like pattern between the QRS complexes. (CDISC)


Neck sprain

Stretching or tearing of ligaments in the neck.


Laceration of liver

A cut or tear in the liver.


Incomplete Left Bundle Branch Block by ECG Finding

An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the left ventricle, manifest as a widened initial portion of the QRS complex in leads V5, V6, I and aVL and with QRS duration less than 120 ms. (CDISC)


Left Main Coronary Artery Stenosis, Percentage

The percentage of narrowing of the left main coronary artery.


Extraocular Muscle Paresis

A slight or incomplete paralysis of an extraocular muscle.


Open globe injury

A full thickness wound of the eyewall (sclera and cornea). (Birmingham Eye Trauma Terminology System (BETTS))


Primary Exertional Headache

Headache triggered by exercise.


Pregnancy Related Skin Change

Alterations in the skin's appearance during pregnancy due to hormonal level changes.


Atrial Premature Complex by ECG Finding

An electrocardiographic finding of an ectopic impulse originating in the atria and not specifically in the sinus node. The P wave morphology of these complexes is often different from a sinus P wave and the RR intervals preceding these complexes is also shorter than those of the regular beats. (CDISC)


Active Caries

Tooth decay that is increasing in size or scope.


Hemorrhagic ascites

Accumulation of hemorrhagic fluid in the peritoneal cavity.


Late Fetal Death

Death of a fetus at 16 weeks, 0 days to 19 weeks, 6 days of gestation.


Hemorrhage of spermatic cord

Bleeding originating from the spermatic cord.


Chemical burns of eye

Injury to the eye secondary to a chemical substance.


Sternocleidomastoid Injury Related to Birth

Disruption of the sternocleidomastoid muscle incurred during delivery.


Vas deferens obstruction

Blockage of the normal flow of the sperm in the vas deferens.


Bowel Burn

A thermal, chemical or radiation injury to the bowels.


injury of rectum with open wound into cavity

Trauma to the rectum associated with a break in the tissue that extends into the rectum.


Brachial Plexus Palsy

An injury that results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm. In the majority of cases there is spontaneous recovery.


Bone injury

Trauma to bone.


Pleural Effusion, Malignant

A collection of fluid in the pleural cavity resulting from malignant disease. Malignant pleural effusions often contain free-floating malignant cells.


Endoleak

Persistent blood flow/pressure in the aneurysm sac following an endovascular aneurysm repair (EVAR) procedure.


Bradycardia Arrest

Cardiac arrest that was a result of bradycardia.


Connective and Soft Tissue Finding

Symptoms, physical examination results, and/or laboratory test results related to the connective and soft tissue.


Fetal Hypoxemia

Abnormally low arterial blood oxygen concentration in a fetus.


Muscular Tic

An involuntary, compulsive, repetitive stereotyped movement, usually of the face or shoulders.


Unspecified renovascular hypertension

High blood pressure caused by renal artery stenosis.


Nervous System Finding

Symptoms, physical examination results, and/or laboratory test results related to the nervous system.


Early Fetal Death

Death of a fetus at 10 weeks, 0 days to 15 weeks, 6 days of gestation.


Neurogenic Orthostatic Hypotension

Orthostatic hypotension due to autonomic dysfunction. Primary neurogenic orthostatic hypotension (nOH) may be associated with disorders such as Parkinson disease (PD) and multiple system atrophy (MSA) whereas secondary nOH may be seen in peripheral neuropathies.


Delayed Postpartum Hemorrhage

Excessive blood loss between 24 hours after delivery through four weeks that requires intervention.


Poor Sucking Reflex

Uncoordinated or ineffective drawing of saliva or breast milk by a newborn infant.


Abnormal Sensation of Face and Limbs

Sensations of the face and limbs that are not considered normal.


Tongue biting

Clamping of the teeth on the tongue, as can accompany a seizure. (ACC/AHA)


Injury of ear

Trauma to the ear.


Chronic Maternal Hypertension

Hypertension that predates pregnancy.


Junctional premature complex (disorder)

An electrocardiographic finding of an ectopic impulse originating in the AV junction presenting as a QRS complex of supraventricular origin which is not preceded by a P wave. (CDISC)


Immunodeficiency due to Quantitative Defects

An indication that an immunodeficiency disorder is caused by a partial or complete loss of one or more of the hematopoietic cell lineages that are involved in host defense.


Injury of duodenum with open wound into abdominal cavity

Trauma to the duodenum associated with a break in the tissue that extends into the abdominal cavity.


Drug-induced Syncope

A condition in which syncope occurs due to the ingestion or administration of a chemical substance. (ACC/AHA)


Hand Injuries

Trauma to the hand.


Bursa injury

Trauma to a bursa.


Abnormal Gait and Coordination

Gait and coordination movements that are not considered normal.


Endobronchial Obstruction

Partial or complete blockage of the bronchial lumen by a pathological process that occurs within the bronchus.


Mottling

Irregularly shaped, patchy discolorations in the skin.


Third Trimester Antepartum Hemorrhage

Excessive blood loss within the third trimester but prior to onset of labor.


Iris pigment epithelial cyst

A cystic lesion arising from the iris pigment epithelium at the posterior iris surface. (WHO 2018)


Abortion complete

Expulsion of all the products of conception following spontaneous, medical or operative pregnancy termination.


Induced Abortion Finding

Abortion brought on intentionally.


Corneal burn

Chemical or radiant injury to the cornea.


Right Ventricular Dysfunction

Impairment of the right ventricular function associated with low ejection fraction and decreased motility of the right ventricular wall.


Arteriovenous graft aneurysm

A bulge in a weakened wall segment of an arteriovenous graft.


Spermatic cord obstruction

Blockage of the normal flow of the contents of the spermatic cord.


Atrial Fibrillation by ECG Finding

An electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregularly irregular ventricular response. (CDISC)


Intra-Atrial Conduction Delay by ECG Finding

An electrocardiographic finding of a delay in impulse propagation through the atria. This is characterized by broad P waves which are often biphasic in V1. (CDISC)


Hematosalpinx

The presence of blood in a fallopian tube.


Associated Pulmonary Arterial Hypertension

Pulmonary hypertension that results from another disorder (e.g., connective tissue disorder).


ST Segment Abnormality by ECG Finding

An electrocardiographic finding of ST segment elevation or depression.


Ovarian Hyperandrogenism

Increased production of androgens by the ovaries.


Exit Block by ECG Finding

An electrocardiographic finding in which impaired conduction or automaticity within the sinus node results in the failure of impulse transmission from the sinoatrial node. This is manifested as dropped P waves during sinus rhythm. (CDISC)


Intraoperative Venous Injury

Damage to a vein during a surgical procedure.


Hemorrhage of testis

Bleeding originating from the testis.


Resuscitated Cardiac Arrest Event

Cardiac arrest that is reversed, usually by CPR and/or defibrillation or cardioversion, or cardiac pacing.


Disturbance of Skin Sensation

Disruption of the normal functioning of the sensory nerves in the skin.


Early Stillbirth

Delivery of a dead fetus greater than 22 weeks but less than 28 weeks gestational age, and/or whose birth weight is greater than 500 grams but less than 1,000 grams.


Injury of gallbladder

Trauma to the gallbladder.


Intraoperative Ocular Injury

Damage to the eye during a surgical procedure.


Heart Sound

Auditory vibrations of varying intensity (loudness), frequency (pitch), quality, and duration noted during auscultation of the thorax as part of the examination of the cardiovascular system. (ACC/AHA)


Neonatal melena

Abnormally dark tarry feces containing blood, usually due to gastrointestinal bleeding or swallowed maternal blood in neonates.


Opioid-Induced Constipation

Constipation that results from, or follows, treatment with an opioid or opioid-containing medication.


Closed injury of kidney

Trauma to the kidney without indication of associated damage to the skin and other internal and external tissues.


Paroxysmal atrioventricular block

An electrocardiographic finding of the sudden onset of transient AV block, which is often associated with preexisting conduction disorders. (CDISC)


Arm Or Hand Hypoesthesia

Consisting of abnormally decreased sensitivity, particularly to touch in the arm or hand.


Delayed Epiphyseal Fusion

Abnormally late fusion of the bone growth plate.


Surgical Shock

Hypoperfusion of body tissues occurring during or after a surgical procedure, and resulting in cellular injury and vital organ dysfunction.


Cardiac perforation

The presence of an acquired hole in the heart. Cardiac perforation may or may not be symptomatic and may or may not be self sealing. (ACC)


Female Reproductive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the female reproductive system.


Central Nervous System Signs and Symptoms

Signs and symptoms associated with disturbances within the central nervous system, which includes the brain, spinal cord and meninges.


Intraoperative Digestive System Injury

Damage to any part of the digestive system during a surgical procedure.


Proprioceptive Hallucination

Perception of the orientation of the body in space, manifesting as a sensation of floating, flying, in the absence of a corresponding stimulus.


Syncope with Exertion

A condition in which syncope occurs either during or after physical activity. (ACC/AHA)


Premature Epiphyseal Fusion

Abnormally early fusion of the bone growth plate.


Vasodepressor Syncope

A condition in which neurally-mediated syncope occurs in which the blood pressure falls and the heart rate increases. (ACC/AHA)


Cardiac Arrest Prior to Percutaneous Coronary Intervention

Cardiac arrest which occurs before a percutaneous coronary intervention can take place. (ACC)


Toxic Erythema of Chemotherapy

Painful red or purple patches, edematous plaques or blisters on the hands, feet, extremities or intertriginous regions; the onset can occur days to months after receiving chemotherapy.


Neonatal Vaginal Discharge

Secretions which may be thin or tenacious, mucoid or glairy, grayish or milky, occasionally blood tinged, that originate in the vagina and are a consequence of the residual influence of maternal estrogen.


Vasovagal Reaction

Sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the activity of the vagus nerve. It may be triggered by emotions of fear or pain or gastrointestinal upset and may be relieved by lying down while keeping the legs elevated.


Illegal Abortion

Unlawfully induced expulsion of all products of conception.


Postcoital bleeding

Non-menstrual bleeding that occurs during or after sexual intercourse.


Hemorrhage of vas deferens

Bleeding originating from the vas deferens.


Injury of musculoskeletal system

Damage to the muscles, bones and their supportive structural attachments.


Immediate Postpartum Hemorrhage

Cumulative blood loss of greater than or equal to 1000 ML or blood loss accompanied by signs or symptoms of hypovolemia within 24 hours following the birth process (includes intrapartum loss). (reVITALize)


Infectious Hidradenitis

Hidradenitis that is caused by an infectious agent, usually a bacterium.


Skin Type

A distinctive characteristic of the skin marked by the amount of sebum secreted by sebaceous glands.


Binocular Diplopia

Perception of two images secondary to misalignment of the eyes.


Gum injury

Trauma to the gingiva


Atrioventricular Reentrant Tachycardia by ECG Finding

An electrocardiographic finding of a regular supraventricular tachycardia which utilizes an atrioventricular bypass tract as its retrograde limb (orthodromic tachycardia) or as its antegrade limb (antidromic tachycardia). QRS complexes during sinus rhythm may show preexcitation. During orthodromic tachycardia the preexcitation is not present and a retrograde P wave may appear after the QRS complex. During antidromic tachycardia the QRS complex is preexcited. (CDISC)


Labial Fusion

Usually found in girls between 6 months and 6 years of age, this condition occurs wherein the labia grow together instead of as 2 separate folds, thereby blocking the opening of the vagina. It is caused by conditions such as repeated diaper rash, urine and stool infections, and sexual abuse. The condition often spontaneously corrects or responds to the application of estrogen cream.


Fecal Urgency

A continual or recurrent inclination to evacuate the bowels.


Rathke Cleft Cysts

Rathke's pouch cysts are rarely symptomatic in the first two decades of life though they may produce symptoms in the third and fourth decades of life.  When the cysts do present in the first decades of life, the symptoms are generally associated with diabetes insipidus or other conditions related to hypopituitarism.


COVID-19-Associated Acute Digestive System Injury

Acute digestive system injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Hypertension secondary to endocrine disorder

A condition of high blood pressure occurring in association with diseases of the endocrine glands.


In Utero Bowel Perforation

Bowel perforation in utero that may result in meconium peritonitis.


Benign congenital hypotonia

Mild hypotonia that usually appears early in infancy and has a favorable outcome. It is not a manifestation of another disorder that may cause hypotonia (e.g., cerebral palsy or muscular dystrophy).


Malignant biliary obstruction

Blockage in the biliary tract caused by a malignant neoplasm.


Aortic Injury

Damage to the aorta from traumatic or pathologic processes.


Secondary caries

A carious lesion adjacent to an existing restoration.


Reflex

An automatic instinctive unlearned reaction to a stimulus.


Focal Motor Weakness

Impairments of brain function, the nerve or spinal cord that affect a specific region of the body.


Psychogenic syncope

A condition in which syncope occurs due to a conversion disorder. (ACC/AHA)


Urostomy Site Bleeding

Hemorrhage from the urostomy site.


Spontaneous Preterm Birth

Preterm birth from 20 weeks to 36 weeks, 6 days of gestation associated with one of the following: classic preterm labor or preterm premature rupture of membranes.


Peritumoral Brain Edema

An intracranial edema that develops around a tumor in the meninges or brain.


Perforation of jejunum

A rupture in the jejunal wall due to traumatic or pathologic processes.


Prostatic perforation

An opening in the prostate gland due to traumatic or pathologic processes.


Heat Sensation

An internal feeling of being warmer without a concomitant change in the ambient environment. (ACC/AHA)


Varicose veins of lower extremity

An abnormally dilated superficial vein in the legs.


Injury of cardiac valve

An event causes abnormal valve function; this is usually a tear in leaflet or chordae tendinae and manifests as a new regurgitant. (ACC)


Muscle Weakness Trunk

A reduction in the strength of the trunk muscles.


Blood Pressure Finding

A test result that reports the diastolic and systolic pressure of the blood.


Syncope with High Risk Cardiac Characteristics

A sudden loss of consciousness with loss of postural tone not related to anesthesia with high risk characteristics. High risk characteristics include non-ischemic dilated cardiomyopathy, or ischemic heart disease with significant ventricular dysfunction, hypertrophic cardiomyopathy, Brugada Syndrome, or Long QT Syndrome. (ACC)


COVID-19-Associated Acute Intestinal Injury

Acute intestinal injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Berry Aneurysm

A small cerebral artery aneurysm, characterized by a saccular appearance, that typically forms at the junction of vessels in the circle of Willis.


Cisplatin-Induced Tinnitus

Tinnitus that is caused by exposure to cisplatin.


Grade 3 Seizure, ASTCT ICANS

Any clinical seizure focal or generalized that resolves rapidly or nonconvulsive seizures on EEG that resolve with intervention, as defined by the American Society for Transplantation and Cellular Therapy (ASTCT) and the Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) Consensus Grading for Adults.


Congenital obstruction of ureteral orifice

Complete or partial blockage of the ureter at the point where it enters the bladder that is present at birth.


Digestive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the digestive system.


Muscle Weakness Left-Sided

A reduction in the strength of the muscles in the left side of the body.


Ventricular Tachycardia by ECG Finding

An electrocardiographic finding of three or more consecutive complexes of ventricular organ with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC)


Varicose veins of lower extremities with inflammation

Inflammation of enlarged and tortuous veins in the hip, thigh, leg and/or foot.


Spermatic Cord Perforation

An opening in the wall of the spermatic cord.


Hemorrhage in bile duct

Bleeding originating from the bile duct.


Closed injury of eyeball

Traumatic injury to one or more intraocular structures without full thickness wound of the eyewall (sclera and cornea). (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Hemorrhage of pancreas

Bleeding originating from the pancreas.


Cardiac Arrest Requiring Cardiopulmonary Resuscitation

Cardiac arrest that is treated by CPR and/or defibrillation, regardless of outcome.


Integumentary System Finding

Symptoms, physical examination results, and/or laboratory test results related to the integumentary system.


Diplopia, Unilateral

Perception of more than one image when viewing with one eye.


Neutrophilic Eccrine Hidradenitis

Painful red or pink edematous nodules most commonly found on the palmar and/or plantar regions.


Injury of nose

Trauma to the nose.


Traumatic chylothorax

Accumulation of lymph fluid in the pleural cavity as a result of thoracic trauma.


Jaundice, Hemolytic

Jaundice occurring as a result of red blood cell rupture.


Indicated Preterm Birth

Preterm birth from 20 weeks to 36 weeks, and 6 days of gestation that is necessitated by the medical condition of the mother or fetus.


Arteriovenous graft stenosis

Narrowing of the lumen of an arteriovenous graft.


Acquired supradiaphragmatic diverticulum of esophagus


Testicular perforation

A rupture through the testicular tissue.


Arrhythmia by ECG Finding

An arrhythmia that is detected on an electrocardiograph.


Late Pregnancy Loss

The loss of a pregnancy between 13 and 22 weeks.


Carious Dentin

Tooth decay that has invaded the dentin, creating dentin that is partially demineralized and containing mineral crystals in the tubules.


Myocardial Contusions

A bruise to the heart.


Faceplant

A syncopal event in which there is no attempt to protect oneself from the effects of the fall.


Injury to kidney with open wound into cavity

Trauma to the kidney associated with a break in the tissue that extends into the retroperitoneum.


Grade 4 Seizure, ASTCT ICANS

Life-threatening prolonged seizure (>5 min); or repetitive clinical or electrical seizures without return to baseline in between seizures, as defined by the American Society for Transplantation and Cellular Therapy (ASTCT) and the Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) Consensus Grading for Adults.


Congenital Testicular Failure

Testicular failure, the cause of which is present at birth.


Miscarriage in second trimester

Pregnancy loss between 14 weeks 0 days and 21 weeks 6 days gestation.


Multifocal Atrial Premature Complex by ECG Finding

An electrocardiographic finding of premature atrial complexes which have 2 or more distinct morphologies, suggesting origin at more than one atrial site. (CDISC)


Diminished mental function after chemotherapy.


Postpartum Shock

Severe loss of blood pressure leading to inadequate tissue perfusion after the delivery of the fetus.


Acquired solitary multilocular renal cyst

A single cyst in the kidney with several compartments.


injury of esophagus with open wound into cavity

Trauma to the esophagus associated with a break in the tissue that extends into the thoracic cavity.


Left Bundle Branch Block by ECG Finding

An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the left ventricle, manifested as a widened initial portion of the QRS complex in leads V5, V6, I and aVL and with QRS duration greater than or equal to 120 ms. (CDISC)


Persistent Fetal Bradycardia

A decrease in the fetal heart beat rate below 110 per minute or below the normal baseline value expected for the particular fetal age for a period of more than 10 minutes.


Contusion of liver

Bruising of the liver.


Rupture of globe

Full thickness wound of the eyewall (cornea and/or sclera) due to blunt trauma. (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Intraocular Pressure

The fluid pressure within the eye.


Persistent Fetal Tachycardia

A fetal heart rate above 160 bpm that is sustained for longer than 10 minutes.


Peripheral Embolus

Acute occlusion of a peripheral blood vessel resulting from intravascular migration of material. Examples of embolic material include thrombus, fat, bone marrow, air, and amniotic fluid. (ACC)


Injury of liver without open wound into abdominal cavity

Trauma to the liver without indication of associated damage to the skin and other internal and external tissues.


Left ventricular aneurysm

A bulge or ballooning in the wall of the left ventricle of the heart.


Nontraumatic rupture of bladder

Rupture in the bladder wall due to a pathologic process, in the absence of trauma.


Cerebral Venous Aneurysm

A balloon type pouch or bulge in the wall of a cerebral vein.


Rectal Obstruction

Blockage of the normal flow of the intestinal contents in the rectum.


Foot Injuries

Trauma to the foot.


Urethral Perforation

A rupture in the wall of the urethra due to traumatic or pathologic processes.


Intraoperative Hepatobiliary Injury

Damage to the hepatic parenchyma and biliary tract during a surgical procedure.


Central nervous system epidermoid tumor

A lesion which is characterized by an irregularly nodular opalescent wall which has caused it to be termed a "pearly tumor". The Intramural contents are soft and waxy with a variable amount of cholesterol.


Laryngopharyngeal Dysesthesia

A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx.


Legally Induced Abortion

Lawfully induced expulsion of all products of conception.


Prostatic Obstruction

Squeezing of the urethra secondary to enlargement of the prostate gland, resulting in voiding symptoms (straining to void, slow urine stream, and incomplete emptying of the bladder).


Frequent Premature Atrial Complexes by ECG Finding

An electrocardiographic tracing demonstrating frequent premature atrial contractions that exceed an acceptable, predetermined threshold. Different thresholds may apply to different patient populations.


Decreased Best Corrected Visual Acuity

Diminished clarity of vision despite optimal optical correction (glasses and/or contacts).


Eye Finding

Symptoms, physical examination results, and/or laboratory test results related to the eye.


Lupus Headache

A severe, persistent headache that occurs in patients with systemic lupus erythematosus, and is nonresponsive to narcotic analgesia.


Unspecified postpartum hypertension

High blood pressure in the period of time immediately after labor and delivery.


idiopathic precocious puberty

Precocious puberty for which no underlying cause can be identified.


Normal Sinus Rhythm

An electrocardiographic finding of an atrial rhythm which originates from the sinoatrial node that is considered normal for the population. There are no extra beats or conduction abnormalities. (CDISC)


Late Preterm Birth

Birth when a fetus is between 34 weeks and 0 days through 36 weeks and 6 days gestational age.


Back Arching

A convex curvature of the spine that occurs when an individual thrusts forward the shoulders and pulls back the abdomen.


Antepartum Stillbirth

Fetal death greater than or equal to 20 weeks of gestation prior to labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond.


Injury of pancreas

Trauma to the pancreas.


Syncope due to Pulmonary Hypertension

A condition in which syncope occurs associated with a sudden and severe increase in pulmonary vascular resistance. (ACC/AHA)


Pharyngeal Dysesthesia

An unusual sensation in the area of pharynx. It may be the initial manifestation of seizures associated with temporal lobe epilepsy.


Vessel perforation

Damage to a blood vessel resulting from a full thickness disruption in the integrity of the vessel wall.


Foreign Body in Digestive Tract

Extraneous material located within the gastrointestinal tract.


Ocular Contusion

A closed globe injury without violation of the eyewall (cornea and/or sclera), resulting in injury to one or more intraocular structures. (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Atrial perforation

A rupture in atrial tissue due to traumatic or pathologic processes.


Cardiovascular System Finding

Symptoms, physical examination results, and/or laboratory test results related to the cardiovascular system.


Second trimester bleeding

Excessive blood loss within the second trimester but prior to onset of labor.


Superior vena cava stenosis

Abnormal narrowing of the lumen of the superior vena cava.


Cold Sensation

An internal feeling of being cooler without a concomitant change in the ambient environment. (ACC/AHA)


Injury to Inferior Vena Cava

Damage to the inferior vena cava from traumatic or pathologic processes.


Immune System Finding

Symptoms, physical examination results, and/or laboratory test results related to the immune system.


Cyst of parathyroid

An epithelium-lined, fluid-filled cyst containing parathyroid hormone that is usually located in an inferior parathyroid gland, but may be found in other locations in the neck or mediastinum.


Malignant pericardial effusion

Presence of fluid in the pericardial space as a complication of malignant disease.


Laceration of esophagus

A torn, ragged, mangled wound, or an accidental cut of esophagus.


Bladder hemorrhage

Bleeding originating from the urinary bladder wall.


Miscarriage in first trimester

Pregnancy loss at less than 14 weeks 0 days gestation.


Hemorrhage from ureter

Bleeding originating from the ureter.


Head and Neck Finding

Symptoms, physical examination results, and/or laboratory test results related to the head and neck.


Dissecting aneurysm of the thoracic aorta

A dissecting aneurysm formed between the intimal and medial layers of the wall of the proximal portion of the descending aorta proceeding from the arch of the aorta.


Fetal Finding

Any intrauterine symptom or result related to the fetus.


Incomplete Right Bundle Branch Block by ECG Finding

An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the right ventricle, manifested by a widened initial portion of the QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration less than 120 ms. (CDISC)


Disturbance in Bowel Function

Abnormal functioning of the small and/or large intestine.


Unifocal Atrial Premature Complex by ECG Finding

An electrocardiographic finding of premature atrial complexes which have a single distinct morphology, suggesting origin at one atrial site.


Acquired chylothorax

Chylothorax that results from malignancies (usually lymphoma), trauma to the thoracic duct, tuberculosis, or sarcoidosis.


Heart Injuries

Trauma to the cardiac muscle or valves.


Respiratory System Finding

Symptoms, physical examination results, and/or laboratory test results related to the respiratory system.


Level of Consciousness

The level of awareness of an organism.


Locally Advanced Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Vulvar Acquired Melanocytic Nevus

A benign nevus that arises from the vulva during childhood and grows with increasing age.


Cocarboxylase

An organic chloride salt of thiamine(1+) diphosphate.


A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion.


right lung

Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA].


left lung

Lung which consists of the left upper lobe and left lower lobe.[FMA].


Mucous polyp of cervix

A polypoid lesion that arises from the cervix and contains mucus.


WHO Grade 1 Glioma

A category of low grade gliomas that includes subependymal giant cell astrocytoma, pilocytic astrocytoma, angiocentric glioma, and subependymoma.


Third Ventricle Pilocytic Astrocytoma

A pilocytic astrocytoma occurring in the third ventricle.


Recurrent Pilocytic Astrocytoma

The reemergence of pilocytic astrocytoma after a period of remission.


Adult Pilocytic Astrocytoma

A pilocytic astrocytoma occurring in adults.


Recurrent WHO Grade 1 Glioma

The reemergence of WHO grade 1 glioma after a period of remission.


Adult Subependymoma

A subependymoma that occurs during adulthood.


Refractory WHO Grade 1 Glioma

WHO grade 1 glioma that is resistant to treatment.


Adult Subependymal Giant Cell Astrocytoma

A subependymal giant cell astrocytoma occurring in adults.


Recurrent Childhood Subependymal Giant Cell Astrocytoma

The reemergence of subependymal giant cell astrocytoma in childhood after a period of remission.


Childhood Subependymal Giant Cell Astrocytoma

Subependymal giant cell astrocytoma that occurs during childhood.


Recurrent Childhood Pilocytic Astrocytoma

The reemergence of pilocytic astrocytoma in childhood after a period of remission.


Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Perinatal intracranial hemorrhage

Bleeding within the skull of a newborn infant occurring around the time of birth.


Perinatal intraventricular hemorrhage

Bleeding within the cerebral ventricles occurring around the time of birth.


Perinatal subependymal hemorrhage with intraventricular and intracerebral extension

A hemorrhage that involves the subependymal region, the lateral cerebral ventricles and the brain tissue occurring around the time of birth.


Subependymal haemorrhage

Bleeding within the subependymal germinal matrix.


Intraventricular hemorrhage of prematurity

Bleeding within the cerebral ventricles in a preterm infant.


Intracranial tumor hemorrhage

A  brain hemorrhage caused by an intracranial tumor.