tetrapyrrole catabolic process

The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


negative regulation of corticosteroid hormone secretion

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion.


positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.


Terramycin

A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the adjacent tertiary amino group of oxytetracycline; major species at pH 7.3.


double-stranded telomeric DNA binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to double-stranded telomere-associated DNA.


Hypertonic uterine dysfunction

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon


cellular response to stem cell factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus.


cadmium ion binding

Binding to a cadmium ion (Cd).


positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway.


Estrogen Effect

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon


C-acetyltransferase activity

Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule.


interleukin-1 receptor complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A protein complex that binds interleukin-1; comprises an alpha and a beta subunit.


plus-end directed microfilament motor activity

A motor activity that generates movement along a microfilament towards the plus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers.


regulation of spontaneous neurotransmitter secretion

Any process that modulates the frequency, rate or extent of spontaneous neurotransmitter secretion.


phenylalanine-tRNA ligase activity

Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).


endopeptidase Clp complex

A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form.


vitamin D3 metabolic process

The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol.


Hypopigmentation of the fundus

Reduced pigmentation of the fundus, typically generalised. Fundoscopy may reveal a low level pigment in both RPE and choroid with clear visibility of choroidal vessels (pale/albinoid) or low pigment level in the RPE with deep pigment in choroid so that visible choroidal vessels are separated by deeply pigmented zones (tesselated/tigroid).


sinoatrial node development

The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.


mesothelioma

A usually malignant and aggressive neoplasm of the mesothelium which is often associated with exposure to asbestos.


arginine-tRNA ligase activity

Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).


negative regulation of mitotic cell cycle, embryonic

Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle.


lipopolysaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.


sulfate adenylyltransferase (ATP) activity

Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate.


dopamine neurotransmitter receptor activity, coupled via Gi/Go

Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.


response to gonadotropin-releasing hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


cellular response to luteinizing hormone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus.


protein localization to M-band

Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere.


alpha-(1,2)-fucosyltransferase activity

Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage.


negative regulation of axon regeneration

Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.


BMP receptor activity

Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity.


Abnormal lymphocyte count

Any abnormality in the total number of lymphocytes in the blood.


alpha-1,2-mannosyltransferase activity

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.


Any process that modulates the frequency, rate or extent of regulation of ubiquitin-specific protease activity (deubiquitinase) activity.


inhibin-betaglycan-ActRII complex

A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B.


regulation of lactation

Any process that modulates the frequency, rate or extent of lactation.


gamma-aminobutyric acid catabolic process

The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.


Absent eyebrow

Absence of the eyebrow.


primary sex determination

The sex determination process that results in the initial specification of sexual status of an individual organism.


mitotic telomere maintenance via semi-conservative replication

Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle.


intracellular oxygen homeostasis

A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell.


ribonucleoside bisphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar.


T-helper cell lineage commitment

The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes.


growth plate cartilage chondrocyte proliferation

The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.


negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.


extracellular matrix-cell signaling

Any process that mediates the transfer of information between the extracellular matrix and a cell.


cysteinyl-tRNA aminoacylation

The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


positive regulation of hindgut contraction

Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.


hyperostosis

Excessive thickening of bone.


outer mitochondrial membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane.


negative regulation of aldosterone biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.


purine nucleobase transmembrane transport

The process in which a purine nucleobase is transported across a membrane.


positive regulation of osteoclast development

Any process that activates or increases the frequency, rate or extent of osteoclast development.


positive regulation of prostaglandin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


histone H3-K14 acetylation

The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.


forebrain astrocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.


positive regulation of adiponectin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell.


smooth endoplasmic reticulum calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings.


snRNA stem-loop binding

Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.


inositol monophosphate 1-phosphatase activity

Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate.


Shortened PR interval

Reduced time for the PR interval (beginning of the P wave to the beginning of the QRS complex). In adults, normal values are 120 to 200 ms long.


regulation of metanephric ureteric bud development

Any process that modulates the frequency, rate or extent of metanephric ureteric bud development.


cellular response to norepinephrine stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.


regulation of kainate selective glutamate receptor activity

Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity.


Pleural Infection

An infectious process affecting the pleura.


coenzyme A catabolic process

The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.


glutamate-cysteine ligase complex

An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine.


phospholipase C-activating angiotensin-activated signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


gap junction channel activity involved in cell communication by electrical coupling

Any gap junction channel activity that is involved in cell communication by electrical coupling.


postganglionic parasympathetic fiber development

The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.


positive regulation of synaptic transmission, dopaminergic

Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.


positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling

Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade.


skin tag

A small, benign growth that arises from the skin. It is characterized by the presence of fibrovascular tissue lined by epidermis. It may be sessile or pendulous and usually occurs in sites where there is friction.


tricellular tight junction

An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet.


guanosine-containing compound catabolic process

The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines).


oleic acid binding

Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid.


Small intestinal perforation

A hole (perforation) in the wall of the small intestine.


terpene metabolic process

The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups.


hormone-mediated apoptotic signaling pathway

The series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered.


Melanonychia

Brown or black discoloration of the nails.


regulation of intracellular sterol transport

Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells.


supercoiled DNA binding

Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.


ciliary pocket

Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes.


Abnormal blood ion concentration

Abnormality of the homeostasis (concentration) of a monoatomic ion.


angiotensin-activated signaling pathway involved in heart process

An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.


regulation of heart rate by hormone

The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.


metanephric mesenchymal cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state.


response to diacyl bacterial lipopeptide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus.


Female sexual arousal disorder

A disorder characterized by a recurrent or persistent inability to attain or maintain until completion of sexual activity an adequate physical response of sexual excitement, consisting of vasocongestion in the pelvis, vaginal lubrication and expansion, and swelling of the external genitalia.


protein kinase 5 complex

A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent.


spinal cord ventral commissure morphogenesis

The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized.


VEGF-activated neuropilin signaling pathway

The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


somatostatin receptor signaling pathway

A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process.


protein K29-linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation.


positive regulation of memory T cell activation

Any process that activates or increases the frequency, rate or extent of memory T cell activation.


maintenance of unfolded protein

Maintaining a protein in an unfolded, soluble state.


Abnormal eosinophil count

Any deviation from the normal number of eosinophils per volume in the blood circulation.


histone methyltransferase binding

Binding to a histone methyltransferase enzyme.


Fractured humerus

A partial or complete breakage of the humerus.


adenylosuccinate synthase activity

Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate.


response to acrylamide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus.


regulation of mesenchymal stem cell proliferation

Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation.


telomere tethering at nuclear periphery

The process in which a telomere is maintained in a specific location at the nuclear periphery.


lymphatic system disorder

A disease involving the lymphatic part of lymphoid system.


oligohydramnios

A lower than normal quantity of amniotic fluid in the amniotic sac as compared to normal values. Typically associated with an amniotic fluid index (AFI) of less than 5 cm or a single maximum vertical pocket (MVP) of less than 2 cm.


Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine.


uridine metabolic process

The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.


positive regulation of response to reactive oxygen species

Any process that activates or increases the frequency, rate or extent of response to reactive oxygen species.


Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.


pulmonary embolism and infarction

Localized necrosis of lung tissue caused by obstruction of the arterial blood supply, most often due to pulmonary embolism.


epigenetic programming in the zygotic pronuclei

The global programming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process.


cellular response to nitrite

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus.


congenital absence of upper arm and forearm with hand present

A congenital malformation in which the upper portion of a limb is either shortened or absent.


NADPH regeneration

A metabolic process that generates a pool of NADPH by the reduction of NADP+.


hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group.


olfactory pit development

The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx.


smooth muscle contractile fiber

The contractile fiber of smooth muscle cells.


regulation of pancreatic stellate cell proliferation

Any process that modulates the frequency, rate or extent of pancreatic stellate cell proliferation.


Blighted ovum

Pregnancy loss with visible gestational sac or yolk sac or both but no visible embryo on ultrasonogram.


interleukin-4 receptor activity

Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


extraocular skeletal muscle development

The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.


regulation of chorionic trophoblast cell proliferation

Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation.


proteoglycan sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans.


RZZ complex

A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints.


negative regulation of hepatocyte proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation.


Intrarenal abscess

An encapsulated collection of pus and necrotic material within the renal parenchyma. The destruction of renal parenchyma is associated with suppurative/neutrophil-rich inflammation and necrosis.


negative regulation of post-translational protein modification

Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification.


negative regulation of mast cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process.


spermidine biosynthetic process

The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.


Pyle disease

A bone dysplasia characterized by genu valgum, metaphyseal anomalies with broadening of the long bones extending into the diaphyses and giving the femora and tibiae an 'Erlenmeyer flask'' appearance, widening of the ribs and clavicles, platyspondyly and cortical thinning.


sequence-specific single stranded DNA binding

Binding to single-stranded DNA of a specific nucleotide composition.


positive regulation of blood vessel remodeling

Any process that activates or increases the frequency, rate or extent of blood vessel remodeling.


long-chain fatty acyl-CoA binding

Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.


pyoderma

Any skin disease that is pyegenic.


glutamate receptor clustering

The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane.


Klinefelter syndrome

A sex chromosome disorder caused by the presence of an extra X chromosome in the male karyotype. Affected individuals are infertile and have a small penis and testes. They tend to have tall stature and long legs and may have difficulties with speech and language development. Gynecomastia may be present.


epidermal growth factor receptor activity

Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


fatty-acyl-CoA transport

The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A).


blood vessel lumenization

The process in which a developing blood vessel forms an endothelial lumen through which blood will flow.


negative regulation of receptor catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process.


positive regulation of protein K63-linked ubiquitination

Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination.


sensory neuron axon guidance

The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.


epidermolysis bullosa

Epidermolysis bullosa (EB) is a group of genetic skin diseases that cause the skin to blister very easily. Blisters form in response to minor injuries or friction, such as rubbing or scratching. There are four main types of epidermolysis bullosa: dystrophic epidermolysis bullosa Epidermolysis bullosa simplex Junctional epidermolysis bullosa Kindler Syndrome Identifying the exact type can be hard because there are many subtypes of EB. Within each type or subtype, a person may be mildly or severely affected. The disease can range from being a minor inconvenience to completely disabling, and fatal in some cases. Most types of EB are inherited. The inheritance pattern may be autosomal dominant or autosomal recessive. Management involves protecting the skin, reducing friction against the skin, and keeping the skin cool.


response to acetate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus.


regulation of heart induction by regulation of canonical Wnt signaling pathway

Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes.


protein insertion into mitochondrial inner membrane

The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane.


positive regulation of translational initiation by iron

Any process involving iron that activates or increases the rate of translational initiation.


Neonatal death

Death within the first 28 days of life.


ripoptosome assembly involved in necroptotic process

The aggregation, arrangement and bonding together of ripoptosome components leading to a necroptotic process.


platelet activating factor receptor activity

Combining with platelet activating factor to initiate a change in cell activity.


metanephric glomerular epithelium development

The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.


acetyl-CoA C-acetyltransferase activity

Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.


host intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.


aminomethyltransferase activity

Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.


arteritic anterior ischemic optic neuropathy

An anterior ischemic neuropathy that is the cause of vision loss that occurs in temporal arteritis (aka giant cell arteritis)


MAML1-RBP-Jkappa- ICN1 complex

A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.


regulation of atrial cardiac muscle cell membrane depolarization

Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte.


2,4-dienoyl-CoA reductase (NADPH) activity

Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.


complement receptor mediated signaling pathway

The series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway.


positive regulation of histone H4-K16 acetylation

Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation.


serotonin uptake

The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.


mesenchymal cell differentiation involved in lung development

The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.


sodium-dependent multivitamin transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate.


liver angiosarcoma

A malignant vascular neoplasm arising from the liver.


very-low-density lipoprotein particle receptor activity

Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.


dTDP biosynthetic process

The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).


protein-arginine omega-N symmetric methyltransferase activity

Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.


thiamine diphosphate metabolic process

The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.


Morbid thoughts

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


regulation of meiotic cell cycle phase transition

Any process that modulates the frequency, rate or extent of meiotic cell cycle phase transition.


negative regulation of cytoplasmic translational elongation

Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation.


negative regulation of mitochondrial membrane permeability

Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.


cell pole

Either of two different areas at opposite ends of an axis of a cell.


negative regulation of synapse maturation

Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation.


Osseous metaplasia

Heterotopic formation of normal bone within soft tissue.


Kaposi's sarcoma

A malignant neoplasm characterized by a vascular proliferation which usually contains blunt endothelial cells. Erythrocyte extravasation and hemosiderin deposition are frequently present. The most frequent site of involvement is the skin; however it may also occur internally. It generally develops in people with compromised immune systems including those with acquired immune deficiency syndrome (AIDS).


panniculitis

Inflammation of the subcutaneous adipose tissue.


mitochondrial membrane fission

A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission.


primary myelofibrosis

Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.


negative regulation of chemokine (C-C motif) ligand 5 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5.


conditioned taste aversion

A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.


ornithine transport

The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


Antitussive therapy

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laryngeal neoplasm

A benign or malignant neoplasm involving the larynx.


ribonuclease MRP activity

Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.


agoraphobia

An anxiety disorder characterized by an intense, irrational fear of venturing out into open places or situations in which help (or escape) might not be available should excessive anxiety or panic symptoms develop.


primitive neuroectodermal tumor

A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm constitutes the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems and includes some glial cell precursors.


skeletal muscle satellite cell activation

The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.


disorder of lacrimal gland

A disease that involves the lacrimal gland.


seryl-tRNA aminoacylation

The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.


beta-adrenergic receptor activity

Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.


diffuse idiopathic skeletal hyperostosis

This syndrome is characterized by the association of ankylosing vertebral hyperostosis with hyperkeratosis of the soles and palms.


Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R.


negative regulation of lipoprotein oxidation

Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation.


pancreas disorder

A non-neoplastic or neoplastic disorder that affects the pancreas. Representative examples of non-neoplastic disorders include pancreatitis and pancreatic insufficiency. Representative examples of neoplastic disorders include cystadenomas, carcinomas, lymphomas, and neuroendocrine neoplasms.


regulation of Fas signaling pathway

Any process that modulates the frequency, rate or extent of Fas signaling pathway.


thyroid-stimulating hormone receptor activity

Combining with thyroid-stimulating hormone to initiate a change in cell activity.


Purkinje myocyte development

The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.


hydrogen sulfide biosynthetic process

The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.


NAD(P)+ nucleosidase activity

Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide.


Rab geranylgeranyltransferase activity

Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.


carotid artery occlusion

A occlusion precerebral artery that involves the carotid artery segment.


negative regulation of NLRP3 inflammasome complex assembly

Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly.


diffuse alopecia areata

An alopecia areata that involves diffuse loss of hair over the whole scalp.


phosphomannomutase activity

Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.


regulation of lymphangiogenesis

Any process that modulates the frequency, rate or extent of lymphangiogenesis.


flavin-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position.


catechol O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.


N-terminal protein amino acid methylation

The methylation of the N-terminal amino acid of a protein.


positive regulation of aldosterone biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.


axillary vein

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Vein that drains the axilla.


Cloudy urine

The appearance of the urine having visible material in suspension, i.e., appearing cloudy.


Shu complex

A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p.


regulation of glucose mediated signaling pathway

Any process that modulates the frequency, rate or extent of glucose mediated signaling pathway.


2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity

Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction mechanism uses 2,3-bisphosphoglycerate as a phosphate donor.


intestinal epithelial structure maintenance

A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.


negative regulation of histone H3-K4 methylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.


oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor.


recycling endosome to Golgi transport

The directed movement of substances from recycling endosomes to the Golgi.


Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.


autoimmune hemolytic anemia, warm type

Warm autoimmune hemolytic anemia is the most common form of autoimmune hemolytic anemia defined by the presence of warm autoantibodies against red blood cells (autoantibodies that are active at temperatures between 37-40B0C).


Normal Liver Function Test

A laboratory test result indicating the results of a liver function test are within normal parameters for the age and population.


lactose metabolic process

The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose.


[pyruvate dehydrogenase (lipoamide)] phosphatase activity

Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate.


sequestering of calcium ion

The process of binding or confining calcium ions such that they are separated from other components of a biological system.


D-erythro-sphingosine kinase activity

Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.


programmed cell death in response to reactive oxygen species

Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.


succinate transmembrane transport

The process in which succinate is transported across a membrane.


co-translational protein modification

The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome.


benign neoplasm of oral cavity

A benign neoplasm that involves the oral cavity.


negative regulation of dopamine metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.


cervical polyp

A polyp that arises from the surface of the cervix.


3'-flap endonuclease activity

Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis.


chondrocyte development involved in endochondral bone morphogenesis

The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.


regulation of translational initiation in response to starvation

Any process that modulates the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.


regulation of memory T cell activation

Any process that modulates the frequency, rate or extent of memory T cell activation.


negative regulation of osteoclast development

Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.


Vascular stenosis

Narrowing of the lumen of an artery or vein.


regulation of hemoglobin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


cholesterol 25-hydroxylase activity

Catalysis of the reaction: AH(2) + cholesterol + O2 = 25-hydroxycholesterol + A + H2O.


regulation of B cell tolerance induction

Any process that modulates the frequency, rate, or extent of B cell tolerance induction.


stapedius muscle

The muscle that stabilizes the stapes bone. The stapedius emerges from a pinpoint foramen in the apex of the pyramidal eminence (a hollow, cone-shaped prominence in the posterior wall of the tympanic cavity), and inserts into the neck of the stapes. [WP,unvetted].


protein import into peroxisome matrix, docking

The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane.


azurophil granule membrane

The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.


Inflammation of the stomach that is associated with Helicobacter Pylori.


myo-inositol transport

The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.


cell surface pattern recognition receptor signaling pathway

The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.


mononeuropathy

Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.


ISG15 transferase activity

Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.


leucyl-tRNA aminoacylation

The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


endoplasmic reticulum Sec complex

An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex.


regulation of nitric oxide mediated signal transduction

Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).


protein K33-linked deubiquitination

A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein.


diadenosine tetraphosphate metabolic process

The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached.


positive regulation of collateral sprouting in absence of injury

Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury.


transferrin receptor activity

Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates.


midbrain morphogenesis

The developmental process by which a midbrain is generated and organized.


regulation of mismatch repair

Any process that modulates the frequency, rate or extent of mismatch repair.


UTP binding

Binding to UTP, uridine 5'-triphosphate.


cellular response to heparin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.


enophthalmos

Abnormal recession of the eyeball within the eye socket.


sRNA-mediated post-transcriptional gene silencing

A post-transcriptional gene silencing pathway mediated by the action of small regulatory non-coding RNAs (sRNAs). sRNAs are 20-500 nucleotides in length and found in bacteria.


glycosylceramide catabolic process

The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group.


haptoglobin binding

Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex.


FATZ binding

Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components.


peptidyl-cysteine oxidation

The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid.


Vestibular areflexia

Vestibular areflexia can be measured as the absence of the caloric nystagmus response in electronystagmography.


disaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units.


interleukin-23 receptor complex

A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.


Ethinamate

A carbamate ester that is the 1-vinylcyclohexyl ester of carbamic acid. A short-acting sedative-hypnotic, it was formerly used to treat insomnia.


purine ribonucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.


regulation of acetylcholine secretion, neurotransmission

Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine.


regulation of voltage-gated chloride channel activity

Any process that modulates the frequency, rate or extent of voltage-gated chloride channel activity.


positive regulation of CD8-positive, alpha-beta T cell activation

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.


Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+.


Perseverative thought

Manifestations of perseverative thoughts are behaviors that do not meet the demands of the situation, are not the product of deliberation, and may unfold despite counter intention.


Post-partum hemorrhage

Significant maternal haemorrhage/blood loss following deilvery of a child.


positive regulation of vitamin metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


PET complex

A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs.


interleukin-23 binding

Binding to interleukin-23.


regulation of I-kappaB phosphorylation

Any process that modulates the frequency, rate or extent of I-kappaB phosphorylation.


retromer, cargo-selective complex

The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals.


immunoglobulin production in mucosal tissue

The synthesis and release of immunoglobulin in the mucosal tissue.


RNA-directed RNA polymerase complex

A protein complex that possesses RNA-directed RNA polymerase activity.


Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA.


regulation of antral ovarian follicle growth

Any process that modulates the frequency, rate or extent of antral ovarian follicle growth.


regulation of T-helper 17 cell lineage commitment

Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment.


type I activin receptor binding

Binding to a type I activin receptor.


6-phosphofructo-2-kinase activity

Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+.


accessory XI nerve

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A cranial nerve that originates from neurons in the medulla and in the cervical spinal cord.


regulation of Rab protein signal transduction

Any process that modulates the frequency, rate or extent of Rab protein signal transduction.


formaldehyde catabolic process

The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde.


Rho GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding.


Pulmonary nodule

Focal rounded or ovoid opacity, not more than 3 cm in diameter. Pulmonary nodules are typically observed by chest radiography or computer tomography imaging.


D3 vitamins binding

Binding to D3 vitamins.


Vogt-Koyanagi-Harada disease

A bilateral, chronic, diffuse granulomatous panuveitis typically characterized by serous retinal detachment and frequently associated with neurological (meningitis), auditory, and dermatological alterations.


neutrophil differentiation

The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.


pyruvate dehydrogenase (acetyl-transferring) activity

Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.


pityriasis versicolor

A yeast infection usually manifested as a superficial skin infection. It may also present as a systemic infection in patients who are receiving total parenteral nutrition.


regulation of transcription from RNA polymerase II promoter in response to iron

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus.


renal inner medulla development

The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney.


latex allergy

Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (hypersensitivity, delayed) and IgE antibody-mediated (hypersensitivity, immediate) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.


C-X-C chemokine receptor activity

Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.


SUMO activating enzyme activity

Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.


lactate biosynthetic process from pyruvate

The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate.


apoptotic process involved in embryonic digit morphogenesis

Any apoptotic process that is involved in embryonic digit morphogenesis.


positive regulation of mitochondrial DNA metabolic process

Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process.


response to angiotensin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.


Burkitt lymphoma

Burkitt lymphoma is a rare form of malignant mature B-cell non-Hodgkin lymphoma.


3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity

Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2.


phosphatidylinositol 3-kinase catalytic subunit binding

Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.


negative regulation of translational elongation

Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.


early endosome to recycling endosome transport

The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes.


activation of blood coagulation via clotting cascade

Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot.


Epidermal growth factor receptor decreased


cell-cell signaling involved in metanephros development

Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ.


paraxial mesodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell.


positive regulation of hematopoietic stem cell migration

Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.


cardiolipin synthase activity

Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.


popliteal artery

The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.


regulation of muscle hyperplasia

Any process that modulates the frequency, rate or extent of muscle hyperplasia.


putrescine metabolic process

The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine.


regulation of eosinophil differentiation

Any process that modulates the frequency, rate or extent of eosinophil differentiation.


suppression by symbiont of host programmed cell death

Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


primitive hemopoiesis

A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells.


skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration

Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells.


interleukin-23 complex

A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.


B cell selection

The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival.


regulation of miRNA processing

Any process that modulates the frequency, rate or extent of microRNA processing.


positive regulation of epithelial cell proliferation involved in prostate gland development

Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.


trisomy 18

Trisomy 18 is a chromosomal abnormality associated with the presence of an extra chromosome 18 and characterized by growth delay, dolichocephaly, a characteristic facies, limb anomalies and visceral malformations.


negative regulation of cellular response to macrophage colony-stimulating factor stimulus

Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus.


regulation of lens epithelial cell proliferation

Any process that modulates the frequency, rate or extent of lens epithelial cell proliferation.


Digitalis toxicity

Acute CNS, visual, GI, and cardiac disturbances caused by an overdose of, or intolerance to, the cardiac glycoside, digitalis.


omegasome

Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the phagophore assembly sites.


resolution of mitotic recombination intermediates

The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged.


minimally invasive lung adenocarcinoma

A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is characterized by a predominantly lepidic pattern and 5 mm or less invasion in greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely may be mucinous.


cytidylate kinase activity

Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.


cadmium ion transport

The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


vertebral column disorder

A disease involving the vertebral column.


gastric dilatation

Abnormal distention of the stomach due to accumulation of gastric contents that may reach 10 to 15 liters. Gastric dilatation may be the result of gastric outlet obstruction; ileus; gastroparesis; or denervation.


prostaglandin D receptor activity

Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.


Carotid sinus syncope

An exaggerated response to carotid sinus baroreceptor stimulation resulting in syncope from transient diminished cerebral perfusion.


oxidative RNA demethylation

The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms.


cardiac cell fate determination

The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.


clathrin-sculpted acetylcholine transport vesicle

A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine.


positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration resulting from the platelet-derived growth factor receptor-beta signaling pathway.


negative regulation of glucagon secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.


Prolonged QRS complex

Increased time for the complex comprised of the Q wave, R wave, and S wave as measured by the electrocardiogram (EKG).. In adults, normal values are 0.06 - 0.10 sec.


mast cell cytokine production

Any process that contributes to cytokine production by a mast cell.


new growing cell tip

A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth.


histamine secretion by mast cell

The regulated release of histamine by a mast cell or group of mast cells.


Abnormal nasal septum morphology

An abnormality of the nasal septum.


negative regulation of nodal signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway.


pulmonary valve insufficiency

Dysfunction of the pulmonary valve characterized by incomplete valve closure.


chylomicron remnant clearance

The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded.


positive regulation of neutrophil apoptotic process

Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process.


negative regulation of MDA-5 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the series of the MDA-5 signaling pathway.


oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule.


periodontal disorder

An inflammatory process of the gingival tissues and/or periodontal membrane of the teeth, resulting in an abnormally deep gingival sulcus, possibly producing periodontal pockets and loss of alveolar bone support.


NAD+ kinase activity

Catalysis of the reaction: ATP + NAD+ = ADP + 2 H+ + NADP+.


Graft Rejection

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


thioester transport

The directed movement of a thioester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


urinary tract obstruction

Blockage of the normal flow of contents of the urinary tract.


parathyroid hormone receptor activity

Combining with parathyroid hormone to initiate a change in cell activity.


Noc4p-Nop14p complex

A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.


rectal prolapse

Protrusion of the rectum through the anus.


positive regulation of endoplasmic reticulum tubular network organization

Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum tubular network organization.


Increased pulmonary vascular resistance

Pulmonary vascular resistance (PVR) more than 3 wood units, as defined by the current definition of pulmonary hypertension. 95% of individuals have a PVR of less than 2.4 wood units.


protein localization to cytosolic proteasome complex

A process in which a protein is transported to, or maintained in, a location within a cytosolic proteasome complex.


germ-line stem cell division

The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.


tocopherol omega-hydroxylase activity

Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O .


interleukin-1, type I, activating receptor activity

Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins.


embryonic ectodermal digestive tract development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure.


purine nucleobase catabolic process

The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.


bacterial conjunctivitis

Inflammation of the conjunctiva caused by a variety of bacterial agents.


regulation of corticotropin-releasing hormone secretion

Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion.


intracellular canaliculus

An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates.


cysteine-type endopeptidase activity involved in execution phase of apoptosis

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis.


Gilbert syndrome

An autosomal recessive inherited disorder characterized by unconjugated hyperbilirubinemia, resulting in harmless intermittent jaundice.


ether biosynthetic process

The chemical reactions and pathways resulting in the formation of ether.


eosinophil fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin.


follicle-stimulating hormone signaling pathway

A G protein-coupled receptor signaling pathway initiated by follicle-stimulating hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


regulation of acute inflammatory response to non-antigenic stimulus

Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.


sequestering of BMP in extracellular matrix

Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.


follicle-stimulating hormone receptor binding

Binding to a follicle-stimulating hormone receptor.


squamous cell lung carcinoma

A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma.


histone H3-K36 dimethylation

The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone.


regulation of opioid receptor signaling pathway

Any process that modulates the frequency, rate or extent of opioid receptor signaling pathway.


luteinizing hormone signaling pathway

A G protein-coupled receptor signaling pathway initiated by luteinizing hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


acid-ammonia (or amide) ligase activity

Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.


protein retention in Golgi apparatus

The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known.


bradykinin receptor activity

Combining with bradykinin to initiate a change in cell activity.


negative regulation of cholesterol import

Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle.


RNA polymerase I general transcription initiation factor binding

Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I.


chiasma

A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over.


common bile duct development

The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine.


indanol dehydrogenase activity

Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+.


Coagulative necrosis

Ischemic tissue necrosis characterized by the preservation of the architectural pattern and a necrotic ghost appearance of the cells.


Premature birth

The birth of a baby of less than 37 weeks of gestational age.


positive regulation of thymocyte apoptotic process

Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process.


yellow nail syndrome

A very rare syndromic disorder characterized by the variable triad of characteristic yellow nails, chronic respiratory manifestations, and primary lymphedema.


rough endoplasmic reticulum lumen

The volume enclosed by the membranes of the rough endoplasmic reticulum.


interleukin-3 receptor binding

Binding to an interleukin-3 receptor.


papillary conjunctivitis

Conjunctivitis that is characterized by the formation of papillae on the palpebral conjunctiva.


cuticular plate

A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.


regulation of calcium ion binding

Any process that modulates the frequency, rate or extent of calcium ion binding.


dopachrome isomerase activity

Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.


superior olivary nucleus development

The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


syndromic agammaglobulinemia

A agammaglobulinemia that is part of a larger syndrome.


negative regulation of response to macrophage colony-stimulating factor

Any process that stops, prevents or reduces the frequency, rate or extent of response to macrophage colony-stimulating factor.


Piperazine

An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.


positive regulation of type II interferon-mediated signaling pathway

Any process that increases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway.


Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine.


Pancreatic pseudocyst

Cyst-like space not lined by epithelium and contained within the pancreas. Pancreatic pseudocysts are often associated with pancreatitis.


Thickened skin

Laminar thickening of skin.


prenylated protein catabolic process

The chemical reactions and pathways resulting in the breakdown of prenylated proteins.


Cellulitis caused by Staphylococcus aureus


regulation of nodal signaling pathway

Any process that modulates the frequency, rate or extent of nodal signaling pathway.


glomerular filtration

The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.


Decreased mean platelet volume

Average platelet volume below the lower limit of the normal reference interval.


deUFMylase activity

A thiol-dependent isopeptidase activity that cleaves UFM1 from a target protein to which it is conjugated.


regulation of progesterone secretion

Any process that modulates the frequency, rate or extent of progesterone secretion.


The microtubule-based process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.


formin-nucleated actin cable assembly

The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


positive regulation of chondrocyte proliferation

Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.


hepatic granuloma

A granuloma located in the liver.


phosphatidylinositol 5-phosphate metabolic process

The chemical reactions and pathways involving phosphatidylinositol 5-phosphate.


tapasin binding

Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules.


mycobacterial infectious disease

Infection due to organisms from the genus Mycobacteria.


chromaffin granule membrane

The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.


metanephric glomerular epithelial cell development

The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells.


type II interferon receptor binding

Binding to a type II interferon receptor. Type II interferon is also known as interferon-gamma.


regulation of ferrous iron binding

Any process that modulates the frequency, rate or extent of ferrous iron binding.


negative regulation of long-chain fatty acid import across plasma membrane

Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane.


alpha-beta T cell proliferation

The expansion of an alpha-beta T cell population by cell division.


The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis.


ventricular compact myocardium morphogenesis

The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.


Delayed Orgasm

Sexual dysfunction characterized by a delay in climax.


farnesol metabolic process

The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.


adenosine receptor binding

Binding to an adenosine receptor.


negative regulation of histone H3-K27 methylation

Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.


Increased muscle fatiguability

An abnormal, increased fatiguability of the musculature.


IRE1-RACK1-PP2A complex

A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A.


phytol metabolic process

The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol.


herpes simplex encephalitis

Herpes simplex virus encephalitis (HSE) is caused by the infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. HSV often involves the frontal and temporal lobes, usually asymmetrically, resulting in personality changes, cognitive impairment, aphasia, seizures, and focal weakness.


bioluminescence

The production of light by certain enzyme-catalyzed reactions in cells.


multifocal atrial tachycardia

Multifocal atrial tachycardia is a rare supraventricular arrhythmia in neonates and young infants that is characterized by multiple P waves with varying P wave morphology and is usually asymptomatic.


infectious otitis media

Inflammation of the anatomical structures of the middle ear secondary to an infectious process. Bacterial etiology is most common, but both viral and fungal pathogens are also possible. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever. In severe infections, inflammation and edema of the structures of the middle ear can lead to perforation of the tympanic membrane secondary to the buildup of pressure in the narrow space.


farnesyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of farnesyl diphosphate.


BAT3 complex

A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A.


positive regulation of dopamine uptake involved in synaptic transmission

Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell.


Scrib-APC-beta-catenin complex

A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.


IDP catabolic process

The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate.


Eyelid Function Disorder

A disorder characterized by impaired eyelid function.


regulation of immune complex clearance by monocytes and macrophages

Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.


glandular epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


positive regulation of oligopeptide transport

Any process that activates or increases the frequency, rate or extent of oligopeptide transport.


Mycoplasma pneumoniae pneumonia

Interstitial pneumonia caused by extensive infection of the lungs (lung) and bronchi, particularly the lower lobes of the lungs, by mycoplasma pneumoniae in humans. In sheep, it is caused by mycoplasma ovipneumoniae. In cattle, it may be caused by mycoplasma dispar.


5-phosphoribose 1-diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.


prostaglandin F receptor activity

Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity.


The series of molecular signals initiated by interleukin-27 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


intermediate mesoderm development

The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.


negative regulation of steroid hormone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion.


bullous keratopathy

Keratopathy that is characterized by the presence of epithelial bullae.


Catalysis of the reaction: 3,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H+.


Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.


positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Any process that activates or increases the frequency, rate or extent of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry.


neutrophil-mediated killing of gram-negative bacterium

The directed killing of a gram-negative bacterium by a neutrophil.


CSF1-CSF1R complex

A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand.


corpus callosum, agenesis of

A congenital abnormality characterized by the complete absence of the corpus callosum. It may be an isolated abnormality or associated with other central nervous system abnormalities or syndromes. Clinical manifestations vary. In cases of isolated corpus callosum agenesis, symptoms may be absent or minimal. In cases that are associated with other central nervous system abnormalities or syndromes, symptoms include developmental delays, motor coordination difficulties, and vision impairment.


super elongation complex

A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae.


negative regulation of protein refolding

Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.


hyaluronoglucuronidase activity

Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate.


glycine cleavage complex

A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.


Bacterial Colonization

The detection of bacteria in or on an anatomic site, medical device or biospecimen.


adult pulmonary Langerhans cell histiocytosis

Adult pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare histiocytic lung disease characterized by the accumulation of Langerhans and other inflammatory cells in the small airways, resulting in the formation of nodular inflammatory lesions.


L-isoleucine transaminase activity

Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.


renal hypodysplasia/aplasia 1

The presence of developmental dysplasia of the kidney.


D-ribose catabolic process

The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose).


anti-glomerular basement membrane disease

An autoimmune disease that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs) and a kidney disease known as glomerulonephritis. Some use the term 'Goodpasture syndrome' for the findings of glomerulonephritis and pulmonary hemorrhage and the term 'Goodpasture disease' for those patients with glomerulonephritis, pulmonary hemorrhage, and anti-GBM antibodies. Currently, the preferred term for both conditions is “ anti-GBM antibody disease ”. Circulating antibodies are directed against the collagen of the part of the kidney known as the glomerular basement membrane (GBM), resulting in acute or rapidly progressive glomerulonephritis. Antibodies also attack the collagen of the air sacs of the lung (alveoli) resulting in bleeding of the lung (pulmonary hemorrhage). Symptoms may include general body discomfort or pain, bleeding from the nose and/or blood in the urine, respiratory problems, anemia, chest pain, and kidney failure. Anti-GBM disease is thought to result from an environmental insult (smoking, infections, exposure to certain drugs) in a person with genetic susceptibility, such as a specific human leukocyte antigen (HLA) type. Diagnosis is confirmed with the presence of anti-GBM antibody in the blood or in the kidney. The treatment of choice is plasmapheresis in conjunction with prednisone and cyclophosphamide.


infectious otitis interna

Inflammation of the anatomical structures of the inner ear secondary to an infectious process. Symptoms include severe vertigo, nausea, vomiting, anxiety, and pain. Viral etiology is most common, and recent history of an upper respiratory infection is common. In rare cases an infection of the middle ear can spread to the inner ear, resulting in a bacterial or fungal etiology.


celiac nerve plexus

A complex network of nerves located in the abdomen behind the stomach. The celiac plexus is located near where the celiac trunk, superior mesenteric artery, and renal arteries branch from the abdominal aorta. It is behind the stomach and the omental bursa and in front of the crura of the diaphragm, on the level of the first lumbar vertebra, L1. The plexus is formed (in part) by the greater and lesser splanchnic nerves of both sides, and also parts of the right vagus nerve. The celiac plexus proper consists of the celiac ganglia with a network of interconnecting fibers. The aorticorenal ganglia are often considered to be part of the celiac ganglia, and thus, part of the plexus. [WP,unvetted].


Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.


female sex determination

The specification of female sex of an individual organism.


high output heart failure

High-output heart failure is a heart condition that occurs when the cardiac output is higher than normal.