Stage III Appendix Neuroendocrine Tumor AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm but less than or equal to 4 cm. T3: Tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. T4: Tumor perforating the peritoneum or directly invading other adjacent organs or structures (excluding direct mural extension to adjacent subserosa of adjacent bowel), e.g., abdominal wall and skeletal muscle. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 5q

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

A rare acute myeloid leukemia that occurs in childhood and is characterized primarily by deletions of 5q.


Locally Advanced Liver Carcinoma

Liver carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Skin Squamous Cell Carcinoma

A squamous cell carcinoma of the skin that has spread from its original site of growth to nearby tissues or lymph nodes.


endometritis following abortion

Endometritis that develops following an abortion.


Conjunctival Reactive Lymphoid Hyperplasia

A polyclonal proliferation of lymphoid tissue in the conjunctiva that typically occurs in young adults. It usually presents as a unilateral, red or orange, painless swelling and is probably caused by chronic antigen stimulation. (WHO 2018)


Supratentorial Glioblastoma

A glioblastoma that occurs in the supratentorial region.


Ostomy Site Pain

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

Pain at the site of an ostomy.


Metastatic Malignant Germ Cell Tumor

A malignant germ cell tumor that has spread from its original site of growth to another anatomic site.


Benign vascular neoplasm

A benign neoplasm arising from vascular tissue usually of the skin.  It is characterized by the presence of vascular channel formation and endothelial cells.


Refractory Mixed Phenotype Acute Leukemia

Mixed phenotype acute leukemia that does not respond to treatment.


Anaemias due to disorders of glutathione metabolism

Anemia resulting from an abnormality of glutathione deficiency.


Stage IIB Merkel Cell Carcinoma AJCC v7

Stage IIB includes: T2/T3, cN0, M0.  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Sexual dysfunction due to substance

A disorder characterized by clinically significant sexual dysfunction (including impaired desire, impaired arousal, impaired orgasm, or sexual pain) that is fully explained by substance use.


Pelvic Cancer

A primary or metastatic malignant neoplasm that affects the organs and structures of the pelvis.


Synchronous Nodules with Dominant Lesion(s)

A finding of multiple pulmonary nodules in which radiologic imaging demonstrates the presence of a dominant lesion.


Adult TdT Positive Acute Lymphoblastic Leukemia

TdT positive acute lymphoblastic leukemia that occurs during adulthood.


Stage IVA Hepatocellular Carcinoma AJCC v8

Stage IVA includes: Any T, N1, M0. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


KATP-Associated Hyperinsulinism

Hyperinsulinism caused by non-functional beta-cell ATP-sensitive potassium channels due to inactivating mutation(s) in either the ABCC8 or KCNJ11 gene.


Third Ventricle Germinoma

A germinoma that arises from the third ventricle.


Stage IIA Fallopian Tube Cancer AJCC v6 and v7

Stage IIA includes: T2a, N0, M0.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Radiating Chest Pain Along Anterior Axillary Line

The location of the radiating chest pain is along an imaginary vertical line that descends along the lateral aspect of the chest wall originating from the armpit.


Liposarcoma recurrent

The reemergence of liposarcoma after a period of remission.


Neoplasm of Uncertain Histogenesis

A benign or malignant, primary or metastatic neoplasm with uncertain histogenesis.


Metaplastic Synovial Cyst

A cyst lined by tissue that resembles synovial villi.


Refractory Fallopian Tube High Grade Serous Adenocarcinoma

Fallopian tube high-grade serous adenocarcinoma that is resistant to treatment.


Paratesticular Squamous Cell Carcinoma

An extremely rare squamous cell carcinoma that arises from the paratesticular structures.


Metastatic Carcinoma in the Liver

A carcinoma that has spread to the liver from another primary anatomic site.  Representative examples include metastatic carcinomas from the colon, breast, and lung.


Diffuse Glioneuronal Tumor with Oligodendroglioma-Like Features and Nuclear Clusters

A provisional tumor entity described in the supratentorial brain and characterized by a distinct DNA methylation profile and monosomy of chromosome 14. It is composed of small to medium-sized cells showing perinuclear oligodendroglioma-like haloes, scattered multinucleated cells, and nuclear clusters composed of large pleomorphic nuclei. Most cases have been reported in pediatric patients.


Treatment related acute myeloid leukaemia

An acute myeloid leukemia arising as a result of the mutagenic effect of chemotherapy agents and/or ionizing radiation.  (WHO, 2001)


Transitional cell carcinoma in situ

A lesion in which the surface epithelium of the bladder or the renal pelvis and ureter contains transitional cells which display malignant cytologic characteristics.  There is no evidence of stromal invasion.


Ann Arbor Stage IV AIDS-Related Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Stage III Ampulla of Vater Neuroendocrine Tumor AJCC v8

Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor invading the visceral peritoneum (serosa) or other organs. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Aggressive Systemic Mastocytosis Associated with Germ Cell Tumor

Aggressive systemic mastocytosis associated with a germ cell tumor.


Stage IIIC Appendix Carcinoma AJCC v7

Stage IIIC includes: Any T, N2, M0. N2: Metastasis in four or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Gallbladder Cancer AJCC v6

Stage III includes: (T4, Any N, M0).  T4: Tumor invades main portal vein or hepatic artery or invades multiple extrahepatic organs or structures. (AJCC 6th ed.)


Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8

Stage IIB includes: (T1, N1, M0, Any G); (T3, N0, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Bartholin Gland Hyperplasia

Nodular/lobular proliferation of normal Bartholin gland tissue and ducts.


Refractory Digestive System Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from any part of the digestive system and does not respond to treatment.


Bronchopleural Fistula

An abnormal communication between a bronchus and the pleural cavity.


Refractory Biliary Tract Carcinoma

Biliary tract carcinoma that is resistant to treatment.


Primary Raynaud Phenomenon

Raynaud phenomenon without a known underlying autoimmune disorder.


Gallbladder Mucinous Cystic Neoplasm

An epithelial, usually multiloculated neoplasm arising from the gallbladder. It occurs predominantly in females. Signs and symptoms include abdominal mass, abdominal pain, and jaundice. Morphologically, the cystic spaces are lined by columnar epithelium and contain mucinous or serous fluid.


Advanced Melanoma

Melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Prostate Adenocarcinoma without Neuroendocrine Differentiation

A prostate adenocarcinoma characterized by the absence of focal or diffuse neuroendocrine differentiation.


Metastatic Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that has spread to other anatomic sites.


Adenocarcinoma, Oxyphilic

An adenocarcinoma characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast carcinoma, and salivary gland oncocytic carcinoma.


Non-Neoplastic Uveal Disorder

A non-neoplastic disorder that affects the uvea.


Hodgkin's disease mixed cellularity recurrent

The reemergence of mixed cellularity classic Hodgkin lymphoma after a period of remission.


Pancreatic Acinar Cell Neoplasm

An epithelial neoplasm that arises from the exocrine pancreas.  It is characterized by the presence of neoplastic cells that resemble acinar cells and produce pancreatic exocrine enzymes.  The vast majority are carcinomas.


Lymphangiomatosis

A lymphangioma affecting several anatomic sites.


Metastatic Infiltrating Bladder Urothelial Carcinoma with Giant Cells

Bladder giant cell variant urothelial carcinoma that has spread to another anatomical site.


Uveal prolapse

The protrusion of uveal tissue through an opening in the sclera.


Unresectable Melanoma

Melanoma which is not amenable to surgical resection.


Alcohol-Related Carcinoma

A carcinoma that is caused by alcohol abuse.


Retinoblastoma by AJCC v8 Clinical Stage

A term that refers to the clinical staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition.


Visceral edema

Accumulation of an excessive amount of watery fluid in the visceral tissues. Symptoms include abdominal pain, nausea, vomiting, and diarrhea.


Intermediate Grade B-Cell Non-Hodgkin's Lymphoma


Liver and Intrahepatic Bile Duct Non-Epithelial Neoplasm

A benign or malignant non-epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts.  Representative examples of benign non-epithelial neoplasms include hemangioma, angiomyolipoma, and solitary fibrous tumor.  Representative examples of malignant non-epithelial neoplasms include lymphoma, angiosarcoma, and undifferentiated (embryonal) sarcoma.


undifferentiated carcinoma of anal canal

A usually aggressive malignant epithelial neoplasm that arises from the anal canal.  It is composed of malignant cells which do not display evidence of glandular or squamous differentiation.


Female Reproductive System Carcinoma

A malignant neoplasm that arises from the epithelium of any part of the female reproductive system. Representative examples include ovarian carcinoma, cervical carcinoma, and endometrial carcinoma.


Bile Duct Mucinous Cystic Neoplasm with Intermediate Grade Intraepithelial Neoplasia

A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of moderate atypia.


Stage IIA Merkel Cell Carcinoma AJCC v7

Stage IIA includes: T2/T3, pN0, M0.  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  pN0: No regional lymph node metastasis by pathologic examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Pathologic Stage IA Cutaneous Melanoma AJCC v8

Stage IA includes: (T1a, N0, M0); (T1b, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Stage IIB Gallbladder Cancer AJCC v8

Stage IIB includes: T2b, N0, M0. T2b: Tumor invading the perimuscular connective tissue on the hepatic side, with no extension into the liver. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Hereditary factor VII deficiency disease

A rare autosomal recessive inherited blood coagulation disorder characterized by deficiency of factor VII, resulting in bleeding.


Neonatal infectious disorder

An infectious disorder that occurs during the neonatal period. Representative examples include streptococcal infection, E.coli infection, and bacterial meningitis.


Resectable Glioblastoma

A glioblastoma that is amenable to surgical resection.


Locally Advanced Non-Cutaneous Melanoma

Non-cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Endometrial Mucinous Adenocarcinoma, Intestinal-Type

A rare mucinous adenocarcinoma arising from intestinal metaplasia of the endometrium.


Blood Cardiac Troponin T Increased

A laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen.


Dog Bite

A wound received from the teeth of a dog.


Secondary malignant neoplasm of skin

The spread of a malignant neoplasm to the skin.  This may be from a primary skin malignant neoplasm, or from a malignant neoplasm at a distant site.


Stage I Centroblastic Follicular Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Female Reproductive System Precancerous Condition

A precancerous lesion that arises from the female reproductive system. Representative examples include atypical endometrial hyperplasia, endometrial intraepithelial neoplasia, and cervical intraepithelial neoplasia.


Primary Bone Hodgkin Lymphoma

An exceedingly rare Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement.


Adult Anaplastic Astrocytoma

An astrocytoma occurring in adults that is characterized by the presence of high mitotic activity, cytologic atypia, and architectural distortion.


Locally Advanced Digestive System Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from any part of the digestive system and has spread to nearby tissues or lymph nodes.


Factor XI Inactivation

Presence of inactivating antibodies to factor XI in the blood.


Extrahepatic Bile Duct Carcinoid Tumor

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the extrahepatic bile ducts. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Vaginal Cancer by AJCC v7 Stage

A term that refers to the staging of vaginal cancer according to the American Joint Committee on Cancer, 7th edition.


Pure Erythroid Leukemia

Acute erythroid leukemia characterized by the presence of immature erythroid cells in the bone marrow (at least 80% of the cellular component), without evidence of a significant myeloblastic cell population present.


H influenze type B Meningitis

Meningitis that is attributed to the bacteria H influenze type B.


Urothelial carcinoma ureter recurrent

Reemergence of ureter urothelial carcinoma after a period of remission.


Stage IA Testicular Cancer AJCC v8

Stage IA includes: pT1, N0, M0, S0. pT1: Testicular cancer which is limited to testis (including rete testis invasion) without lymphovascular invasion. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


Stage II Cervical Cancer AJCC v8

Stage II includes: T2, Any N, M0. T2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina. M0: No distant metastasis. (AJCC 8th Ed.)


Rhinocephaly

A congenital anatomic defect characterised by the presence of a proboscis-like nose located above the eyes, which are partially or completely fused.


human anaplasmosis

An infection that is caused by Anaplasma phagocytophilum, which is transmitted to humans by infected ticks; it is characterized by fever, headache, chills, and myalgia.


Psychosis, Brief Reactive

A disorder characterized by delusions, hallucinations, disorganized speech, and/or grossly disorganized behavior that resolve within a month.


Stage IV Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


Condyloma acuminata of vulva

A benign human papillomavirus-related neoplasm that arises from the vulva. It is characterized by the presence of papillary structures with fibrovascular cores covered by stratified squamous epithelium showing koilocytotic changes.


Upper Aerodigestive Invasive Malignancy

A finding indicating the presence of an invasive upper aerodigestive tract malignancy.


Lugano Classification Stage IIE Adult Lymphoma AJCC v8

Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Childhood Lymphocyte-Rich Classic Hodgkin Lymphoma

Lymphocyte-rich classic Hodgkin lymphoma occurring in childhood.


High Grade Anal Intraepithelial Neoplasia

Anal canal or perianal skin intraepithelial neoplasia with moderate or severe dysplasia.


Stage 0 Merkel Cell Carcinoma AJCC v7

Stage 0 includes: Tis, N0, M0.  Tis: In situ primary tumor.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Mandibular Buccal Bifurcation Cyst

An inflammatory collateral cyst that arises on the lower first or second molars. (WHO 2017)


Recurrent Biliary Tract Carcinoma

The reemergence of a carcinoma arising from any part of the biliary tract after a period of remission.


Gallbladder Flat Biliary Intraepithelial Neoplasia

Biliary intraepithelial neoplasia that affects the gallbladder epithelium.  It is characterized by the absence of intraluminal micropapillary projections.


Midgut Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the jejunum, ileum, proximal colon, or appendix. The Ki-67 index is higher than 20%.


Chronic Bullous Disease of Childhood

A blistering disorder characterized by linear deposition of IgA at the dermoepidermal junction.


Vaginal Cancer by AJCC v6 Stage

A term that refers to the staging of vaginal cancer according to the American Joint Committee on Cancer, 6th edition.


Therapy-Related Cytogenetically Normal Acute Myeloid Leukemia

Acute myeloid leukemia not associated with cytogenetic abnormalities and arising as a result of the mutagenic effect of chemotherapy and/or ionizing radiation.


Childhood Grade II Meningioma

A grade II meningioma that occurs during childhood.


Periosteal Desmoid Tumor

A reactive, benign fibrous lesion that develops in the periosteum of the femur.  It usually affects boys and there is a history of trauma.  It is characterized by the formation of dense collagen tissue and reactive bone.


Stage IIB Testicular Cancer AJCC v8

Stage IIB includes: (Any pT/TX, N2, M0, S0); (Any pT/TX, N2, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Bacterial Zoonoses

A bacterial infection that is transmitted from animals to people.


Mucosal Melanoma of the Genitourinary System

A malignant melanocytic neoplasm that arises from a mucosal site of the genitourinary system.


Bone Tuberculosis

Tuberculosis of the bone.


Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome

An acute myeloid leukemia developing in patients with a prior history of myelodysplastic syndrome.


Refractory Malignant Mastocytosis

Malignant mastocytosis that is resistant to treatment.


Recurrent Ependymoma

The reemergence of ependymoma after a period of remission.


Malposition of Ureter

Orientation of a ureter in an unusual anatomic location.


Glioblastoma with Primitive Neuronal Component

A glioblastoma characterized by the presence of well-demarcated nodules which contain primitive cells exhibiting neuronal differentiation.


Congenital Phrenic Nerve Palsy

Damage to the phrenic nerve that results in paralysis of the hemidiaphragm at birth.


Stage III Prostate Cancer AJCC v7

Stage III includes: T3a-b, N0, M0, Any PSA, Any Gleason.  cT3a: Tumor with extracapsular extension (unilateral or bilateral).  pT3a: Tumor with extraprostatic extension or microscopic invasion of bladder neck.  T3b: Tumor invades seminal vesicle(s).  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Small Cell Glioblastoma

A small cell glioblastoma that is resistant to treatment.


FIGO Stage IC Gestational Trophoblastic Tumor


Stage IA Cervical Cancer AJCC v8

Stage IA includes: T1a, Any N, M0. T1a: Tumor diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IVB Bladder Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Non-lymph node distant metastases. (AJCC 8th ed.)


Musculoskeletal Chest Pain due to Slipping Rib Syndrome

A condition in which there is musculoskeletal chest pain associated with one or more ribs subluxing from the joint. (ACC/AHA)


Genetic anomaly of leukocyte

An abnormality of leukocytes, the cause of which is present from birth.


Weight Gain Due to Fluid Retention

A finding of rapid weight gain due to fluid retention.


Necrotizing granulomatous inflammation

A granuloma that contains areas of necrosis.  The majority of cases are of infectious origin.


Squamous cell papilloma of eyelid

A papilloma that arises from the eyelid. It is composed of squamous cells and is characterized by the presence of an acanthotic epithelium with hyperkeratosis and papillary projections with an inner fibrovascular core. It is the most common benign epithelial tumor of eyelid. It usually affects middle-aged or older adults.


Ureter Cancer by AJCC v8 Stage

A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. (from AJCC 8th Ed.)


Malignant neoplasm of stomach stage III

Stage III includes: IIIA (T4a, N1, M0); (T3, N2, M0); (T2, N3, M0); IIIB (T4b, N0, M0); (T4b, N1, M0); (T4a, N2, M0); (T3, N3, M0); IIIC (T4b, N2, M0); (T4b, N3, M0); (T4a, N3, M0).  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  T4b: Tumor invades adjacent structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Lymphoma by Working Formulation (Antiquated)


Childhood Acute Leukemia

An acute leukemia that occurs during childhood.


Gastric Poorly Cohesive Adenocarcinoma

An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.  This category includes signet ring cell adenocarcinomas, adenocarcinomas that are composed of malignant cells resembling lymphocytes and histiocytes, and adenocarcinomas that are composed of malignant cells with deeply eosinophilic cytoplasm.


Stage IIIA Gastric Carcinoma

Stage IIIA includes: (T4a, N1, M0); (T3, N2, M0); (T2, N3, M0).  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIIC1 Cervical Cancer AJCC v9

Stage IIIC1 includes: TX, T0, T1-3, N1, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage III Bone Sarcoma AJCC v7

Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Mitochondrial enzyme deficiency

A constellation of disorders whose common thread is the insufficient quantity of one or more mitochondrial enzymes.


Low Grade Lymphoma (neoplasm)

An antiquated term that refers to a non-Hodgkin lymphoma with low grade histologic features.


Radiation-Induced Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is the result of exposure to ionizing radiation.


Angiosarcoma NCI Grade 2

An angiosarcoma with less than 15% necrosis.


Stage IIA Cervical Cancer AJCC v7

Stage IIA includes: IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0).  T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Pathologic Stage I Cutaneous Melanoma AJCC v8

Stage I includes: IA: (T1a, N0, M0); (T1b, N0, M0); IB: (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Acute rheumatic pericarditis

Inflammation of the pericardium in acute rheumatic heart disease.


Squamous Cell Carcinoma of Unknown Primary

A squamous cell carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified.


Malignant Abdominal Neoplasm

A primary or metastatic malignant neoplasm that affects the organs and structures of the abdomen.


Localized Gallbladder Carcinoma

A carcinoma that arises from the gallbladder and it has not spread to other anatomic sites.


Psychomotor Agitation

Physical restlessness, often associated with increased motor activity.


Stage I Pancreatic Cancer AJCC v6 and v7

Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0).  T1: Tumor limited to the pancreas 2 cm or less in greatest dimension.  T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Transitional cell cancer of the renal pelvis and ureter localized

A transitional cell carcinoma of the renal pelvis or ureter confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular or squamous differentiation and giant cells resembling osteoclasts.


Non-Neoplastic Ureter Disorder

A non-neoplastic disorder affecting the ureter.


Tumor contained within organ capsule

A neoplasm surrounded by a fibrous capsule.


Childhood Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for childhood Hodgkin lymphoma based on the Ann Arbor classification criteria.


Poisoning by barbiturate

Disturbances in psychophysiological functions and responses as a result of  administration or ingestion of a member of the barbiturate class of central nervous system depressants.


Metachronous Malignant Neoplasm

A malignant tumor that arises at a site separate from another, primary malignant tumor in the same anatomic system.  It is not clear if metachronous malignant neoplasms represent new primary tumors or metastatic disease.  Examples include metachronous osteosarcoma of the bones that develops in patients with known primary bone osteosarcoma, and metachronous Wilms' tumor that affects the opposite kidney in patients with a history of Wilms' tumor.


Locally Advanced Vulvar Carcinoma

Vulvar carcinoma that has spread to nearby tissues or lymph nodes.


histiocytic sarcoma of central nervous system

Rare involvement of the central nervous system by histiocytic sarcoma.


Pancreatic carcinoma non-resectable

Carcinoma of the pancreas that is not amenable to surgical removal.


Metastatic Malignant Neoplasm in the Lacrimal Drainage System

A malignant neoplasm that has spread from its original site of growth to the lacrimal drainage system.


Peritoneal Diseases

A non-neoplastic or neoplastic disorder that affects the peritoneum.  Representative examples of non-neoplastic disorders include peritonitis and panniculitis.  Representative examples of neoplastic disorders include adenomatoid tumor, primary peritoneal carcinoma, metastatic carcinoma to the peritoneum, and malignant mesothelioma.


Resectable Glioma

A glioma that is amenable to surgical resection.


Vulvar Germ Cell Tumor

A rare germ cell tumor that arises from the vulva.


Hepatitis Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis virus exposure and injury of the liver parenchyma.


Subgaleal Hemorrhage Related to Birth

Bleeding in the potential space between the skull periosteum and the scalp galea aponeurosis of a newborn infant due to shearing forces on the tentorium and deep venous system during labor and delivery.


High Grade Fever

Body temperature of 104 degrees Fahrenheit (40 degrees Celsius) or higher.


Neuroendocrine breast tumor

A well-differentiated neuroendocrine neoplasm that arises from the breast. It may be classified as G1 (low grade) or G2 (intermediate grade) neuroendocrine tumor.


Atypical Gastric Lymphoid Hyperplasia

An atypical lymphoid hyperplasia involving the gastric mucosa.


Unilateral Anophthalmos

A rare congenital abnormality characterized by the complete absence of ocular tissue in one orbit.


46,XX Ovotesticular Difference of Sex Development

The presence of ovarian and testicular tissue in the an individual with 46,XX karyotype. The anatomical expression of this condition is variable.


Stage IA Esophageal Adenocarcinoma AJCC v7

Stage IA includes: T1, N0, M0, G1-2, X. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated. GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Stage IV Appendix Neuroendocrine Tumor AJCC v8

Stage IV includes: (T1, N0, N1, M1); (T2, N0, N1, M1); (T3, N0, N1, M1); (T4, N0, N1, M1). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm but less than or equal to 4 cm. T3: Tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. T4: Tumor perforating the peritoneum or directly invading other adjacent organs or structures (excluding direct mural extension to adjacent subserosa of adjacent bowel), e.g., abdominal wall and skeletal muscle. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Vasogenic Edema

Edema that is characterized by increased permeability of capillary endothelial cells.


Metastatic small cell carcinoma

A small cell neuroendocrine carcinoma that has metastasized from its original site of growth to another anatomic site.


Granulosa cell-theca cell tumor

A general term used to describe sex cord-stromal tumors characterized by the presence of granulosa cells in a thecomatous/fibrothecomatous background.


Gastroesophageal Junction Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction.  It is characterized by the presence of malignant large cells.


Pancreatic Poorly Differentiated Ductal Adenocarcinoma

A pancreatic ductal adenocarcinoma characterized by the presence of small and irregular malignant glandular structures, solid sheets of malignant cells, and single malignant cells.


T-Cell Large Granular Lymphocyte Leukemia, Common Variant

T-cell large granular lymphocyte leukemia defined by the presence of CD3-positive, CD8-positive, and T-cell receptor alpha-beta-positive cytotoxic T-cells.


Gastric Cancer by AJCC v7 Stage

A term that refers to the staging of gastric carcinoma according to the American Joint Committee on Cancer, 7th edition.


Radiculoneuropathy

Spontaneous degeneration of the spinal cord and peripheral nerves characterized by myelin sheath vacuolation, Wallerian degeneration and intramyelinic space infiltration by macrophages.


Muscular Dystrophy Secondary to Mitochondrial Disorder

A muscular dystrophy that was caused by a primary mitochondrial disorder.


Locally Advanced Adenocarcinoma

Adenocarcinoma that has spread to nearby tissues or lymph nodes.


Gallbladder Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Intermediate Bone Neoplasm

A locally aggressive or rarely metastasizing neoplasm that arises from the bone.


Radiation Overdose

A higher than intended cumulative dose of radiation to a single field.


Intraoperative Neurological Injury

Damage to any part of the nervous system during a surgical procedure.


Criminal injury

Trauma resulting from illegal activity.


Unresectable Peritoneal Malignant Mesothelioma

Peritoneal malignant mesothelioma that is not amenable to surgical resection.


Fuchs' adenoma

A benign proliferation of the pars plicata epithelium of the ciliary body. It is associated with aging..


Ann Arbor Stage III Nodular Lymphocyte Predominant Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Myeloid Neoplasms with Germline Predisposition

A term that refers to myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, and acute myeloid leukemias that are associated with germline mutations and are familial.


Stage IIIA Vulvar Cancer AJCC v7

Stage IIIA includes: (T1/T2, N1a/N1b, M0); T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N1a: Vulvar cancer with one or two lymph node metastasis each measuring 5 mm or less.  N1b: Vulvar cancer with one lymph node metastasis measuring 5 mm or greater.  M0: No distant metastasis.  (AJCC 7th ed.)


Malignant Testicular Sertoli Cell Tumor

A Sertoli cell tumor that arises from the testis and is characterized by nuclear pleomorphism, increased mitotic activity and necrotic changes.  Metastases may be present at diagnosis.


Recurrent Malignant Germ Cell Tumor

The reemergence of a malignant germ cell tumor after a period of remission.


Congenital Platelets Abnormality

A group of rare inherited platelet disorders that involve abnormalities of platelet function or platelet production and that usually cause moderate to severe bleeding problems.


Defective Alpha Heavy Chain Present

An indication that cells expressing a mutated or defective form of immunoglobulin heavy chain alpha have been detected in a sample.


Lugano Classification Childhood Hodgkin Lymphoma by AJCC v8 Stage

A staging system for childhood Hodgkin lymphomas based on the Lugano classification criteria. Staging for childhood Hodgkin lymphoma is the same as for the adult counterpart. (from AJCC 8th Ed.)


Adult Angiosarcoma

An angiosarcoma occurring in the adult population.


neoplasm of optic chiasm

A benign or malignant neoplasm that affects the optic chiasm.


Abscess of pituitary

An inflammatory or infectious process in the pituitary gland characterized by a circumscribed, walled collection of purulent material.


High Level of Hyaluronic Acid

A finding indicating high concentrations of hyaluronic acid in a sample.


Metastatic Conjunctival Melanoma

Conjunctival melanoma that has spread from its original site of growth to another anatomic site.


Assault by sharp object

A physical attack with a pointed object.


Localized Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

An undifferentiated high grade pleomorphic sarcoma of bone that occurs in adulthood and has not spread to other anatomic sites.


Refractory Melanoma

Melanoma that does not respond to treatment.


Lugano Classification Hodgkin Lymphoma by AJCC v8 Stage

A staging system for Hodgkin lymphomas based on the Lugano classification criteria. Staging for childhood Hodgkin lymphoma is the same as for the adult counterpart. (from AJCC 8th Ed.)


Central Nervous System Paraganglioma

An extra-adrenal paraganglioma arising from the central nervous system.


Nuclear Cataract Grade 4

A stage of nuclear sclerotic cataract marked by severe yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Tuberculous abscess

An abscess resulting from infection by Mycobacterium tuberculosis.


An epithelioid hemangioendothelioma that has spread from its original site of growth to another anatomic site.


Papillary carcinoma in situ

An epithelial neoplasm with a papillary growth pattern in which the malignant cells are confined to the epithelium, without evidence of invasion.


Unresectable Prostate Carcinoma

Prostate carcinoma that is not amenable to surgical resection.


Olfactory neurogenic tumor

A rare, benign (olfactory neurocytoma) or malignant (olfactory neuroblastoma) neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity.


Grade 2 Nodular Sclerosis Classic Hodgkin Lymphoma

Nodular sclerosis Hodgkin lymphoma in which at least 25% of the tumor nodules contain increased numbers of Reed-Sternberg cells.


Metastatic malignant neoplasm to lacrimal gland

A malignant neoplasm that has spread from its original site of growth to the lacrimal gland.


Malignant Fundus Neoplasm

A primary or metastatic malignant neoplasm that affects the gastric fundus.


Elevated Human Chorionic Gonadotropin

A finding indicating elevated concentrations of human chorionic gonadotropin in a sample.


Stage I Extragonadal Non-Seminomatous Germ Cell Tumor


Stage IIB Fallopian Tube Cancer AJCC v6 and v7

Stage IIB includes: T2b, N0, M0.  T2b: Extension to other pelvic structures.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Polyostotic Langerhans cell histiocytosis

Langerhans cell histiocytosis presenting with multiple sites of involvement.


Stage III Acral Lentiginous Melanoma AJCC v7

Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Diencephalic Glioblastoma

A glioblastoma that occurs in the diencephalon.


Nightmare Disorder

A sleep disorder characterized by the repeated occurrence of frightening dreams which precipitate awakenings from sleep; on awakening, the individual becomes fully alert and oriented and has detailed recall of the nightmare, which usually involves imminent danger or extreme embarrassment to the individual.


Retinoblastoma, spontaneously regressed

An archaic term that refers to benign, non-progressive retinal lesions in patients with mutation of the RB1 gene.


Elevated CEA

A laboratory test result indicating the presence of an increased level of the tumor-associated antigen (TAA) CEA in a biological sample.


Neonatal hyperglycemia

Blood glucose concentration above the upper limit of established reference ranges in a newborn.


Atypical Melanocytic Nevus of Genital Type

A small, well circumscribed melanocytic neoplasm that arises from the vulva and affects women in their reproductive years. It is characterized by the presence of junctional nests of melanocytes. Some of the superficial melanocytes show atypia. During pregnancy the atypical melanocytic changes may appear more prominent. This neoplasm is not associated with the presence of dysplastic nevi in other anatomic areas.


Refractory Prostate Carcinoma

Prostate carcinoma that is resistant to treatment.


Recurrent Female Reproductive System Carcinoma

The reemergence of female reproductive system carcinoma after a period of remission.


Lugano Classification Stage III Childhood Hodgkin Lymphoma AJCC v8

Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Therapy-Related Toxicity - Unacceptable to Patient

Indicates that a toxicity adverse effect has been experienced by a patient, and it is severe enough for the patient to discontinue the treatment.


Tracheal fistula

An abnormal communication between the trachea and another organ or anatomic site.


Transthyretin amyloid cardiomyopathy

Cardiomyopathy resulting from the deposition of misfolded transthyretin. The condition can be classified by the presence (hereditary transthyretin amyloid) or absence (wild-type transthyretin amyloid) of mutation(s) in the TTR gene, encoding transthyretin.


Septic arthritis staphylococcal

Arthritis due to staphylococcal sepsis.


Eating disorder symptom

Abnormal eating behaviors, including binge eating, compulsive eating, emotional eating, night eating, and self-induced vomiting, though not at a level that rises to the diagnosis of eating disorder.


Adenocarcinoma of the prostate metastatic

An adenocarcinoma that arises from the prostate gland and has spread to other anatomic sites.


Bladder Neuroendocrine Neoplasm

A neuroendocrine neoplasm that arises from the bladder.


Stage IB Cervical Cancer AJCC v8

Stage IB includes: T1b, Any N, M0. T1b: Tumor with clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. It includes all macroscopically visible lesions, even those with superficial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Recurrent Intermediate Grade Adult Non-Hodgkin's Lymphoma


Venous Stroke

Ischemic or hemorrhagic stroke resulting from cerebral venous thrombosis.


Fetus Small for Gestational Age with Oligohydraminos

A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and shows evidence of oligohydramnios.


Cervical Cancer by FIGO Stage 2009

A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2009.


Non-Neoplastic Central Nervous System Disorder


Stenosis

Narrowing or stricture of a vessel, duct or canal.


Vascular disorder of intestine

A non-neoplastic or neoplastic vascular disorder that affects the intestines.


Cerebellar sarcoma

An obsolete term referring to desmoplastic medulloblastoma.


Gastric Non-Neoplastic Polyp

A non-neoplastic polyp that arises from the stomach.  This category includes hyperplastic polyps and hamartomatous polyps.


Recurrent Childhood Diffuse Astrocytoma

The reemergence of diffuse astrocytoma in childhood after a period of remission.


Haptoglobin Decreased

A laboratory test result which indicates decreased levels of haptoglobin in a biological specimen.


Stage IIIA Esophageal Cancer AJCC v7

Stage IIIA includes: For squamous cell carcinoma: (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IB2 Cervical Cancer AJCC v8

Stage IB2 includes: T1b2, Any N, M0. T1b2: Tumor with clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Radiation anemia

Anemia arising due to radiation therapy.


Invasive listeriosis

A bacterial infection by Listeria monocytogenes in a sterile body compartment.


Testicular Hypotrophy

Less than expected testicular size.


Stage 0 Pancreatic Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. This includes high-grade pancreatic intraepithelial neoplasia (PanIn-3), intraductal papillary mucinous neoplasm with high-grade dysplasia, intraductal tubulopapillary neoplasm with high-grade dysplasia, and mucinous cystic neoplasm with high-grade dysplasia.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Defects in Intrinsic and Innate Immunity

A group of diseases or disorders caused by genetic defects within the immune system, comprised by: Mendelian susceptibility to mycobacterial disease (MSMD); Epidermodysplasia verruciformis (HPV); Predisposition to severe viral infection; Herpes simplex encephalitis (HSE); Predisposition to invasive fungal diseases; Predisposition to mucocutaneous candidiasis; TLR signaling pathway deficiencies with bacterial susceptibility; and other inborn errors of immunity related to nonhematopoietic tissues.


Lymphocyte-Depleted Classic Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for lymphocyte-depleted classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Metastatic Unresectable Sarcoma

A metastatic sarcoma that is not amenable to surgical resection.


Stage IIA Digestive System Neuroendocrine Tumor AJCC v7

Stage IIA includes: T2, N0, M0.  T2: Stomach/ duodenum /jejunum/ileum: tumor invades muscularis propria or is more than 1 cm in size; ampulla: tumor is more than 1 cm in size; colon or rectum: tumor invades muscularis propria or is more than 2 cm in size with invasion of lamina propria or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Locally Advanced Esophageal Adenocarcinoma

Esophageal adenocarcinoma that has spread to nearby tissues or lymph nodes.


Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis

A myelodysplastic/myeloproliferative neoplasm with morphologic and clinical characteristics of refractory anemia with ring sideroblasts, marked thrombocytosis, and abnormal megakaryocytes.


Metastatic Appendix Adenocarcinoma

Appendix adenocarcinoma that has spread from its original site of growth to another anatomic site.


Hodgkin's disease nodular sclerosis stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Posterior Subcapsular Cataract Grade 3

A stage of posterior subcapsular cataract characterized by 50% of the posterior capsule obscured by opacity. (Modified LOCS II)


Ann Arbor Stage III AIDS-Related Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Pancreatic Neuroendocrine Microtumor

A non-functioning pancreatic neuroendocrine tumor measuring less than 0.5 cm in diameter.


Refractory Neoplasm

A neoplasm that does not respond to treatment.


Prostate cancer stage B

Tumor is clinically palpable but confined to the prostate.


Metastatic Anal Canal Carcinoma

An anal canal carcinoma which has spread to another anatomic site.


Malignant Peritoneal and Retroperitoneal Neoplasm

A primary or metastatic malignant neoplasm that affects the peritoneum and/or retroperitoneum.


Hypernatremia

Higher than normal levels of sodium in the circulating blood.


Stage IIA Cervical Cancer AJCC v6

Tumor without parametrial invasion.


Stage IVB Fallopian Tube Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Fallopian tube cancer with liver or splenic parenchymal metastases; metastases to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); transmural involvement of intestine. (from AJCC 8th Ed.)


Stage IIIB Gestational Trophoblastic Tumor AJCC v7

Stage IIIB includes: Any T, M1a, Risk factors: high risk.  M1a: Lung metastasis.  (AJCC 7th ed.)


Recurrent Myxoid Glioneuronal Tumor

The reemergence of myxoid glioneuronal tumor after a period of remission.


Chronic total occlusion of coronary artery

Prolonged complete obstruction of the coronary artery. (ACC)


Lymphoma by AJCC v8 Stage

A term that refers to the staging of Hodgkin lymphoma and non-Hodgkin lymphoma according to the AJCC v8 classification guidelines.


Fibrinolysis Shutdown

Acute impairment of breaking down fibrin clots leading to venous thromboembolism, stroke, and renal failure.


Metastatic Pancreatobiliary Carcinoma

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread from its original site of growth to another anatomic site.


Incarcerated inguinal hernia

The trapping of bowel or omentum inside the inguinal canal that cannot be reduced, resulting in inflammation, pain, nausea, and possible bowel obstruction.


Lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Radiating Chest Pain in Neck

The location of the radiating chest pain is in the neck.


Glycogen storage disease, type IX

Glycogen storage disease usually inherited in an X-linked recessive pattern.  It is characterized by a deficiency of hepatic phosphorylase kinase.


Pinhole meatus

A narrowing of the opening of the urethra at the external meatus.


AIDS-Related Carcinoma

Carcinoma occurring in HIV-positive patients.


Monoclonal Hypergammaglobulinemia

A laboratory test result indicating abnormally high proliferation of the gamma globulins originating from one cell line.


Granuloma annulare aggravated

A chronic, inflammatory skin condition characterized by raised, ring shaped eruptions occurring singly or in groups; often on the tops of the hands, feet, elbows, and knees. It is commonly seen in children and young adults, and in women twice as much as men.


Bladder Cancer by AJCC v6 Stage

A term that refers to the staging of bladder cancer according to the American Joint Committee on Cancer, 6th edition.


Stage I Ampulla of Vater Cancer AJCC v7

Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0). T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades duodenal wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Metastatic Malignant Neoplasm to the Cervix

A malignant neoplasm that has spread to the cervix from another anatomic site.


Anal Canal Intraepithelial Neoplasia

A precancerous neoplastic intraepithelial process involving the anal canal.  When it is clinically noticeable, it may appear as an eczematous or papillary lesion, plaques, or papules.  Morphologically, it is characterized by loss of epithelial stratification and nuclear polarity, cytologic atypia, and the presence of mitotic figures.  It may be classified as low or high grade.


Laryngeal nerve palsy

Damage to the laryngeal nerve that results in paralysis of the layrnx.


Acinar cell tumor

A benign or malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. It includes the acinar cell adenoma and acinar cell carcinoma.


Helicobacter Pylori-Related Malignant Neoplasm


A pleomorphic xanthoastrocytoma that arises from the supratentorial region of the brain.


Spinal nerves paralysis permanent

Spinal nerve paralysis that is irreversible.


Organic failure to thrive

Failure to thrive (FTT), that occurs in less than five percent of FTT cases; it is caused by acute or chronic disorders that interfere with nutritional uptake, including cleft palate, malabsorption due to cystic fibrosis, and short gut syndrome.


Low grade cervical glandular intraepithelial neoplasia

Cervical glandular intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Malignant Pancreatic Vipoma

A pancreatic neuroendocrine tumor producing vasoactive intestinal peptide (VIP).  It is associated with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria.  It displays vascular invasion and metastasizes to other anatomic sites.  One third of cases are metastatic at the time of diagnosis.


Angiosarcoma Associated with Lymphedema

An angiosarcoma that develops in association with long standing lymphedema.


Recurrent Primary Central Nervous System Neoplasm

The reemergence of a primary central nervous system neoplasm after a period of remission.


T/NK-Cell Lymphoproliferative Disorder

A non-neoplastic or neoplastic proliferation of T-lymphocytes and/or NK-cells.


Central Nervous System Langerhans Cell Histiocytosis

Rare involvement of the central nervous system by Langerhans cell histiocytosis.


Injury to peritoneum without mention of open wound into cavity

Trauma to the peritoneum without indication of associated damage to the skin and other internal and external tissues.


Mucinous cystic neoplasm with low-grade intraepithelial neoplasia of gallbladder

A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of mild atypia.


Stage IIIA Testicular Cancer AJCC v8

Stage IIIA includes: (Any pT/TX, Any N, M1a, S0); (Any pT/TX, Any N, M1a, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Sacral Fistula

A pathologic communication between the skin and the dural space that is located 5-25 mm from the anal verge.


Extrahepatic Bile Duct Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Locally Advanced Primary Malignant Brain Neoplasm

A malignant neoplasm that arises from the brain that has spread from its original site of growth to nearby tissues or lymph nodes.


Retinoblastoma, differentiated

A retinoblastoma with well differentiated features. It often produces Flexner-Wintersteiner rosettes or Homer-Wright rosettes. In some cases the tumor cells form fleurettes.


Metastatic Gastric Carcinoma

A gastric carcinoma that has spread from its original site of growth to another anatomic site.


Mesothelioma malignant localised

A mesothelioma with the gross appearance of a circumscribed serosal lesion and the microscopic appearance of diffuse malignant mesothelioma, without evidence of diffuse spread.


Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

The reemergence of a blastic plasmacytoid dendritic cell neoplasm after a period of remission.


Cervical Germ Cell Tumor

A rare germ cell tumor that arises from the cervix. Examples include mature cystic teratoma, yolk sac tumor, and choriocarcinoma.


Hereditary factor I deficiency disease

An inherited blood coagulation disorder characterized by the partial or complete absence of fibrinogen in the blood, resulting in bleeding.


Stage IIC Appendix Carcinoma AJCC v8

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Acoustic shock

Neurophysiological and psychological symptoms caused by sudden and unexpected loud noise.


Liver Small Cell Neuroendocrine Carcinoma

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver. It is characterized by the presence of malignant small cells.


Stage 0 Pancreatic Cancer AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Cutaneous Histiocytic and Dendritic Cell Neoplasm

A histiocytic and dendritic cell neoplasm that affects the skin.


Metastatic Malignant Skin Neoplasm

A malignant neoplasm of the skin that has spread to other anatomic sites.


Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7

A rare acute myeloid leukemia that occurs in childhood and is characterized by deletion of chromosome 7.


Stage IB1 Cervical Cancer FIGO 2018

Invasive cervical carcinoma with equal or more than 5 mm depth of stromal invasion, and less than 2 cm in greatest dimension. (FIGO 2018)


External Ear Pain

Painful sensation in the external ear region.


Fibrinogen Deficiency

A usually inherited blood coagulation disorder characterized by the partial or complete absence of fibrinogen in the blood, resulting in bleeding.


Ampulla of Vater Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.  Patients usually present with advanced stage disease.


Disseminated adenocarcinoma

Adenocarcinoma that is spread throughout the body.


Recurrent Endometrial Squamous Cell Carcinoma

The reemergence of endometrial squamous cell carcinoma after a period of remission.


Unresectable Carcinoma

Carcinoma that is not amenable to surgical resection.


Refractory Metastatic Pancreatic Adenocarcinoma

Metastatic pancreatic adenocarcinoma that is resistant to treatment.


Adult Pleomorphic Hepatocellular Carcinoma

A pleomorphic hepatocellular carcinoma that occurs during adulthood.


POLE-Ultramutated Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by mutations in the exonuclease domain of the DNA polymerase epsilon (POLE) gene that result in an ultra-mutated tumor phenotype.


Cartilaginous hamartoma

A hamartoma characterized by the presence of cartilaginous elements.


Hodgkin's disease nodular sclerosis stage I supradiaphragmatic


Oligodendroblastoma

An obsolete term referring to neoplasms arising from oligodendrocytes.


Recurrent Abdominal Neuroendocrine Neoplasm

The reemergence of an abdominal neuroendocrine neoplasm after a period of remission.


Advanced Sarcoma

A sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Adenovirus Infection

An adenovirus infection that has recurred after a period of remission.


Increased Colloid

Increase in the amount of colloid.


Vitreoretinal Disorder

A disorder affecting the vitreous fluid and retina.


Uterine Non-Neoplastic Disorder

A non-neoplastic disorder that affects the uterine corpus or the cervix. Representative examples include endometritis, uterine adenomyosis, and cervicitis.


Delusional disorder, erotomanic type

A subtype of delusional disorder characterized by the central delusional theme that another person (usually one of higher status) is in love with the individual.


Stage IV Esophagus Carcinoma

Stage IV includes: Any T, Any N, M1. IVA: Any T, Any N, M1a. IVB: Any T, Any N, M1b.  M1: Distant Metastasis. (AJCC 6th ed.) -2003


tubular adenoma of extrahepatic bile duct

An adenoma that arises from the extrahepatic bile ducts.  It is characterized by the presence of a tubular pattern.


EBV-Related Malignant Neoplasm

A malignant neoplasm that develops in a patient infected with Epstein-Barr virus (EBV) and in which there is a well-documented association between the malignancy and EBV. Representative examples include EBV-related lymphomas and carcinomas.


Uterine Ligament Papillary Cystadenoma

A cystadenoma that arises from the broad or other uterine ligaments. It is characterized by the presence of small papillary projections in the inner surface of the cysts. It may be sporadic or associated with von Hippel-Lindau disease.


Stage IV Uterine Corpus Cancer

Stage IV includes: IVA: (T4, Any N, M0); IVB: (Any T, Any N, M1). T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M0: No distant metastasis. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone.  It excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa). This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


neoplasm of optic tract

A benign or malignant neoplasm that affects the optic tract.


Prostate Acinar Adenocarcinoma, Sarcomatoid Variant

A rare morphologic variant of acinar adenocarcinoma of the prostate gland with unfavorable prognosis, composed of both malignant glandular and sarcomatous components.  The sarcomatous component contains a malignant spindle cell proliferation or specific mesenchymal elements including osteosarcoma, chondrosarcoma, and leiomyosarcoma.


Malignant melanoma in giant pigmented nevus

A melanoma arising in a giant congenital melanocytic nevus. The risk of developing a melanoma in a giant congenital melanocytic nevus has been reported to be between 5% and 50%. The incidence of developing melanoma is higher before the age of 10 and in adult life.


Inner Restlessness

A feeling of unrest and/or an inability to feel calm or relaxed.


Early Disseminated Lyme Disease

An early stage of Lyme disease that may present days to weeks after a tick bite with relapsing signs of a red, concentrically-expanding rash (erythema migrans), facial palsy, meningismus, neuralgia, heart palpitations, and dizziness.


Pancreatic Delta Cell Adenoma

An endocrine neoplasm arising from the delta cells of the pancreas which produce somatostatin. It does not show evidence of vascular invasion or metastasis to other anatomic sites.


Transfusion hemosiderosis

Accumulation of iron in internal organs that results from repeated blood transfusions.


Cervical Adenocarcinoma In Situ

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Microinvasive Malignant Neoplasm

A malignant neoplasm that has minimal stromal invasion.


Palsy of accessory nerve

Partial or complete paralysis of the spinal accessory nerve.


Advanced Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Muscle Invasive Bladder Urothelial Carcinoma

A bladder urothelial carcinoma invading into the bladder muscularis propria.


Neurasthenia

An episode of acute, severe anxiety or depression associated with an inability to function as normal.


Subcapsular renal hematoma

A collection of blood between the renal capsule and the renal parenchyma.


Adenocarcinoma, metastatic

An adenocarcinoma that has spread from its original site of growth to another anatomic site.


Non-Neoplastic Retroperitoneal Disorder

A non-neoplastic disorder that affects the retroperitoneum.


Moderately Differentiated Hepatocellular Carcinoma

A hepatocellular carcinoma characterized by the presence of malignant cells with abundant eosinophilic cytoplasm forming trabecular and pseudoglandular patterns.  It is usually associated with tumors that are larger than 3 cm in diameter.


Metastatic Glioblastoma

Glioblastoma that has spread from its original site of growth to another anatomic site.


Immunodeficiency-Related Central Nervous System Lymphoma

A lymphoma that arises from the central nervous system in patients with acquired immunodeficiency conditions or rarely, hereditary immunodeficiency syndromes.


Ampulla of Vater Gangliocytic Paraganglioma

An extra-adrenal paraganglioma that arises from the ampulla of Vater and the periampullary region.  It consists of a mixture of neuroendocrine cells, Schwann-like cells, and ganglion cells.


Acute Megakaryoblastic Leukemia with CBFA2T3-GLIS2

A non-Down syndrome acute megakaryoblastic leukemia that occurs in childhood. It is associated with CBFA2T3-GLIS2 chimeric oncogene and has an unfavorable prognosis.


Desmoplastic trichilemmoma

A variant of tricholemmoma that is characterized by extensive sclerotic stroma formation.


Localized Malignant Neoplasm

A malignant neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Non-Neoplastic Genitourinary System Disorder

A non-neoplastic disorder that affects the genitourinary system.


Stage IIA Esophageal Adenocarcinoma AJCC v7

Stage IIA includes: T2, N0, M0, G3.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis. G3: Poorly differentiated.  (AJCC 7th ed.)


Hyponatremia with Hypoosmolality

Abnormally low serum sodium levels in the setting of electrolyte/fluid imbalance. This condition may be the result of excessive intake or retention of water and/or excretion of salt.


Iodine deficiency

A deficiency of iodine in the diet.


Airsickness

A sensation of discomfort associated with air travel that may include nausea, vomiting, dizziness, or sweating.


Stage II Appendix Carcinoma AJCC v8

Stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4a: Tumor invades through the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or serosa of the mesoappendix. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Childhood Gliosarcoma

The reemergence of gliosarcoma in childhood after a period of remission.


Adenosis

Any disease or disorder of a gland, characterized by abnormal development or enlargement of the gland.


Metastatic Primary Malignant Central Nervous System Neoplasm

A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to other sites.


Mild esophageal dysplasia

A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal epithelium.  (WHO, 2000)


Prostate Acinar Adenocarcinoma, Microcystic Variant

A variant of acinar prostate adenocarcinoma characterized by the presence of microcystic foci in radical prostatectomy specimens.


Congenital stenosis of pulmonary artery

A congenital cardiovascular abnormality characterized by the narrowing of the lumen of the main pulmonary artery or its branches. It may be associated with other congenital heart malformations. Signs and symptoms include dyspnea, tachypnea, tachycardia, fatigue, and edema.


AIDS-Related Pelvic Inflammatory Disease

Pelvic inflammatory disease that develops in a patient with HIV/AIDS.


Stage I Merkel Cell Carcinoma AJCC v7

Stage I includes: IA: (T1, pN0, M0) and IB: (T1, cN0, M0).  T1: Primary tumor equal or less than 2 cm in size.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Hidroacanthoma simplex

A rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct.


Lugano Classification Limited Stage Childhood Hodgkin Lymphoma AJCC v8

Limited stage childhood Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


HPV-related carcinoma

A carcinoma associated with the presence of human papillomavirus infection.


Gestational Trophoblastic Neoplasm by AJCC v8 Stage

A term that refers to the staging of a gestational trophoblastic neoplasm according to the American Joint Committee on Cancer, 8th edition. This classification applies to the following neoplasms: invasive hydatidiform mole, gestational choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Complete and partial hydatidiform moles are not included in this classification. The current FIGO classification includes an anatomic stage designated by Roman numeral I, II, III, or IV, followed by the risk factor score expressed in Arabic numerals (e.g., Stage II: 4, Stage IV: 9).  (from AJCC 8th Ed.)


Hodgkin's disease lymphocyte depletion type stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Stage I Gestational Trophoblastic Tumor AJCC v7

Stage I includes: (T1, M0, Risk factors: unknown); IA (T1, M0, Risk factors: low risk); IB (T1, M0, Risk factors: high risk).  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIIA Cervical Cancer FIGO 2009

Cervical carcinoma involving lower one-third of the vagina. (FIGO 2009)


Stage III Ureter Cancer AJCC v7

Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into periureteric fat.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Peritoneal laceration

A cut or tear of the peritoneum.


Digestive System Hemangioma

A hemangioma arising from any part of the digestive system.


FancD2 Nuclear Foci Present

A laboratory test result indicating the presence of Fanconi anemia group D2 protein nuclear foci in cells, in response to DNA damage.


Malignant Esophageal Neoplasm by Topographic Region

Esophageal segments used primarily in pathology, and distinct from the anatomic segments used for clinical purposes.


Colorectal Cancer by Astler-Coller Stage


Postneoadjuvant Therapy Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage II includes: T3, N0, M0. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Acidophil carcinoma

A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic dyes.


Childhood Lymphocyte-Depleted Classic Hodgkin Lymphoma

Lymphocyte-depleted classic Hodgkin lymphoma occurring in childhood.


Transplant-Related Malignant Neoplasm

A malignant neoplasm that arises in a patient with a history of organ transplantation.


Clinical Stage III Esophageal Adenocarcinoma AJCC v8

Stage III includes: (T2, N1, M0); (T3, N0-1, M0); (T4a, N0-1, M0). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


High Hemoglobin Level

A higher than average level of hemoglobin in a sample.


Metastatic Esophageal Carcinoma

A carcinoma that arises from the esophagus and has metastasized to another anatomic site.


Childhood Hodgkin Lymphoma

Hodgkin lymphoma occurring in childhood.


Intracystic Papillary Breast Carcinoma

An intraductal breast carcinoma characterized by a papillary growth within a large cystic duct. There is no evidence of invasion of the breast parenchyma.


Antepartum Obstetric Septic Embolism

Presence of bacterially-infected tissue in the maternal vascular system which originated from a distant site during the antepartum period.


Unresectable Large Cell Neuroendocrine Carcinoma

Large cell neuroendocrine carcinoma that is not amenable to surgical resection.


Carcinomatous ascites

Accumulation of fluid in the peritoneal cavity resulting from the growth of primary or metastatic carcinoma in the peritoneum.


Extrahepatic Bile Duct Lymphoma

A lymphoma that arises from the extrahepatic bile ducts, with the bulk of the disease located at this site.


Stage I Testicular Cancer AJCC v8

Stage I includes: pT1-T4, N0, M0, SX. pT1: Testicular cancer which is limited to testis (including rete testis invasion) without lymphovascular invasion. pT2: Testicular cancer which is limited to testis (including rete testis invasion) with lymphovascular invasion or invades hilar soft tissue or epididymis or penetrates visceral mesothelial layer covering the external surface of tunica albuginea with or without lymphovascular invasion. pT3: Testicular cancer in which the tumor invades spermatic cord with or without lymphovascular invasion. pT4: Testicular cancer in which the tumor invades scrotum with or without lymphovascular invasion. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Keratin-Filled Cyst

A cyst that contains keratin.


Myopathy Secondary to Fatty Acid Oxidation Disorder

A myopathy that was caused by a primary disorder of fatty acid oxidation.


NF1-Associated Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is associated with NF1 gene inactivation and a history of neurofibromatosis type 1.


Lugano Classification Stage IIE Hodgkin Lymphoma AJCC v8

Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Dentophobia

A persistent, irrational fear of treatment, whether preventative or therapeutic, by a dentist, coupled with compulsive desire to avoid any such situation.


Grade 1 Teratoma

A teratoma that contains mature tissue elements and a limited amount of immature tissue elements.


Stage IIIC Vulvar Cancer AJCC v7

Stage IIIC includes: (T1/T2, N2c, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N2c: Vulvar cancer with lymph node metastasis with extracapsular spread.  M0: No distant metastasis.  (AJCC 7th ed.)


Low Leukocyte Count

A lower than average level of leukocytes in a sample.


Vaginal Neuroendocrine Carcinoma

A rare neuroendocrine carcinoma that arises from the vagina. This category includes small cell and large cell neuroendocrine carcinoma.


Pathologic Stage IV Cutaneous Melanoma AJCC v8

Stage IV includes: Any T, Tis, Any N, M1. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. M1: Evidence of distant metastasis. (AJCC 8th ed.)


Hernia with Obstruction without Mention of Gangrene

The protrusion of an organ, or the fascia of an organ, through the wall of the cavity that normally contains it, which results in obstruction, without mention of necrosis of the herniated contents.


Viral gastroenteritis due to Rotavirus

Enteritis attributed to the rotavirus.


Atypical adenomatous hyperplasia

Proliferation of glandular epithelial cells associated with the presence of cytologic atypia and architectural growth pattern changes.


Rare Non-Neoplastic Disorder

A non-neoplastic disorder that is rare.


Stage IVC Appendix Carcinoma AJCC v8

Stage IVC includes: Any T, Any N, M1c, Any G. M1c: Metastasis to sites other than peritoneum. (AJCC 8th ed.)


Recurrent Digestive System Neuroendocrine Neoplasm

The reemergence of a digestive system neuroendocrine neoplasm after a period of remission.


Cutaneous Rosai-Dorfman Disease

Rosai-Dorfman disease affecting the skin. It manifests with multiple papules, nodules, or plaques.


Hypoxic ischemic encephalopathy neonatal

Injury to the central nervous system in the newborn period that occurs when there is insufficient delivery of oxygen to all or part of the brain.


Status Migrainosus

An episode of migraine that persists for more than 72 hours.


Refractory T-Cell Prolymphocytic Leukemia

T-cell prolymphocytic leukemia that is resistant to treatment.


Locally Advanced Malignant Neoplasm

A malignant neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Recurrent Mature T-Cell and NK-Cell Neoplasm

The reemergence of mature T-cell and NK-cell neoplasm after a period of remission.


uterine cervical atrophy

A condition characterized by the absence of squamous maturation in the cervical epithelium. It is associated with decreased estrogen production.


Peritoneal Dialysis Catheter-Associated Peritonitis

Infection of the peritoneum related to a peritoneal dialysis catheter.


Endometrial Endometrioid Adenocarcinoma with Papillae


Stage IA1 Cervical Cancer AJCC v8

Stage IA1 includes: T1a1, Any N, M0. T1a1: Invasive cervical carcinoma with measured stromal invasion of 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. M0: No distant metastasis. (AJCC 8th Ed.)


Severe Chronic Active EBV Infection

A severe form of chronic Epstein-Barr virus infection characterized by continued intermittent fever, lymphadenopathy, thrombocytopenia, lymphocytopenia, neutropenia, polyclonal gammopathy, and greatly elevated titers for antibodies to EBV-related antigens.


Metastatic Malignant Genitourinary System Neoplasm

A malignant neoplasm that arises from the genitourinary system and has metastasized to other anatomic sites.


Renal pelvis fistula

An abnormal communication between the renal pelvis and another anatomic site.


Metastatic Gallbladder Carcinoma

A gallbladder carcinoma that has spread from the original site of growth to other anatomic sites.


Juvenile Myoclonic Epilepsy, Intractable, without Status Epilepticus

Intractable juvenile myoclonic epilepsy which is not associated with an acute, prolonged epileptic crisis.


Adenocarcinoma gastric recurrent

The reemergence of gastric adenocarcinoma after a period of remission.


Disseminated Listeriosis

A bacterial infection by Listeria monocytogenes in two or more non-contiguous sterile body compartments.


Superficial Epithelioma with Sebaceous Differentiation

A benign epithelial neoplasm occurring in the head, neck or back region. It is characterized by proliferation of basaloid cells in the upper dermis with broad attachments to the epidermis.


Refractory Anaplastic Ganglioglioma

Anaplastic ganglioglioma that is resistant to treatment.


Vaginal Warty Carcinoma

A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, hyperkeratosis, and koilocytosis.


Infection of peritoneal dialysis catheter

A local or systemic infection associated with the use of a peritoneal dialysis catheter.


Human Papillomavirus-Independent Cervical Squamous Cell Carcinoma

A cervical squamous cell carcinoma not associated with human papillomavirus infection.


Stage I Bone Cancer AJCC v8

Stage I includes: IA: (T1, N0, M0, G1 or GX); IB: (T2, N0, M0, G1 or GX); (T3, N0, M0, G1 or GX). T1: Tumor measuring 8 cm or less in greatest dimension. T2: Tumor measuring more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


p53-Mutant Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by the presence of p53 gene mutations.


Tracheal web

A rare congenital or acquired abnormality characterized by the presence of a web-like thin layer of tissue that narrows the lumen of the trachea. It may result in wheezing, dyspnea, and respiratory failure.


Gastric hyperplastic polyp

A non-neoplastic polyp that arises from the stomach and is characterized by the presence of dilated gastric foveoli, edematous changes, and inflammation.


Extrapulmonary Small Cell Carcinoma

A small cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


Refractory Male Reproductive System Carcinoma

Male reproductive system carcinoma that is resistant to treatment.


Proliferative Inflammatory Atrophy

A lesion in the prostate gland characterized by glandular atrophy, chronic inflammation, and epithelial hyperplasia. It has been suggested that it is a precancerous lesion and it may lead to the development of prostatic intraepithelial neoplasia and prostatic carcinoma.


External hemorrhoids (disorder)

A hemorrhoid which originates below the dentate line.


Stage III Vulvar Cancer AJCC v7

Stage III includes: IIIA: (T1/T2, N1a/N1b, M0); IIIB: (T1/T2, N2a/N2b, M0); IIIC: (T1/T2, N2c, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N1a: Vulvar cancer with one or two lymph node metastasis each measuring 5 mm or less.  N1b: Vulvar cancer with one lymph node metastasis measuring 5 mm or greater.  N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less.  N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater.  N2c: Vulvar cancer with lymph node metastasis with extracapsular spread.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent Gastroesophageal Junction Adenocarcinoma

The reemergence of gastroesophageal junction adenocarcinoma after a period of remission.


silent stroke

An asymptomatic cerebral infarction that was incidentally noted by T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensities on an MRI of the brain.


Refractory Acute Myelomonocytic Leukemia

Acute myelomonocytic leukemia that does not respond to treatment.


Postpartum Obstetric Septic Embolism

Presence of bacterially-infected tissue in the maternal vascular system which originated from a distant site during the postpartum period.


Stage IV Acral Lentiginous Melanoma AJCC v6 and v7

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


Human Papillomavirus-Related Verrucous Carcinoma

A verrucous carcinoma that is associated with human papilloma virus (HPV) infection.


Decreased CYBB Expression

An indication that the expression of CYBB is lower than the normal range of values.


Uterine Corpus Cancer by AJCC v6 Stage

A term that refers to the staging of uterine corpus cancer according to the American Joint Committee on Cancer, 6th edition.


Recurrent Ph-Like Acute Lymphoblastic Leukemia

The reemergence of  Ph-like acute lymphoblastic leukemia after a period of remission.


Stage I Intrahepatic Bile Duct Cancer AJCC v8

Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0). T1a: Solitary tumor equal to or less than 5 cm without vascular invasion.  T1b: Solitary tumor larger than 5 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Non-Neoplastic Endocrine Disorder

A non-neoplastic disorder that affects the endocrine system.  Representative examples include diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency.


Non-Metastatic Gestational Trophoblastic Tumor

Gestational trophoblastic tumor that is confined to the site in which it initially manifested.


Preseptal cellulitis

An acute infection of the anterior portion of the eyelid and surrounding tissues.


Injury of phrenic nerve

Damage to the phrenic nerve.


Uterine Corpus Non-Neoplastic Disorder

A non-neoplastic disorder that affects the uterine corpus. Representative examples include endometritis and uterine adenomyosis.


Bone Tumor of Undefined Neoplastic Nature

A group of lesions that affect the bone and have the appearance and cytogenetic or molecular characteristics of neoplasms but the clinical behavior is suggestive of a non-neoplastic process.


Unresectable Neuroendocrine Tumor G1

Carcinoid tumor that is not amenable to surgical resection.


Metastatic Microsatellite Stable Endometrial Carcinoma

Microsatellite stable endometrial carcinoma that has spread from its original site of growth to another anatomic site.


Borderline Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder


Childhood Acute Promyelocytic Leukemia with PML-RARA

An acute promyelocytic leukemia with PML-RARA fusion occurring in children.


Metastatic osteosarcoma

An osteosarcoma which has spread to another anatomical site.


Stage IB Cutaneous Melanoma AJCC v7

Stage IB includes: (T1b, N0, M0); (T2a, N0, M0).  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Tissue or Organ Disruption

A loss of structural integrity within a tissue or organ.


Recurrent Childhood Hodgkin Lymphoma

The reemergence of Hodgkin lymphoma after a period of remission during childhood.


Iris vascular disorder

A vascular disorder or the iris.


Refractory Severe Aplastic Anemia

Severe aplastic anemia that is resistant to treatment.


Stage IIIA Fallopian Tube Cancer AJCC v7

Stage IIIA includes: T3a, N0, M0.  T3a: Microscopic peritoneal metastasis outside the pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Pancreatic Intraductal Tubulopapillary Neoplasm with an Associated Invasive Carcinoma

A pancreatic intraductal tubulopapillary neoplasm characterized by the presence of an invasive carcinomatous component.  The invasive carcinoma has a tubular pattern.


Non-Infectious Gastroenterocolitis

An inflammatory disease of the stomach and intestines due to a non-infectious cause.


Adult Intracranial Meningioma

An intracranial meningioma that occurs during adulthood.


Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8

Stage III includes: IIIA: (T0-2, N1, M0); IIIB: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Non-Neoplastic Vascular Disorder

A term that includes all non-neoplastic vascular disorders.


Pulmonary Granuloma

A granuloma that is located in lung tissue.


Stage III Childhood Large Cell Lymphoma

Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Postneoadjuvant Therapy Stage IV Esophageal Adenocarcinoma AJCC v8

Stage IV includes: IVA: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Pancreatic Cancer by AJCC v6 and v7 Stage

A term that refers to the staging of exocrine and endocrine pancreatic cancer including well-differentiated neuroendocrine tumors according to the American Joint Committee on Cancer, 6th and 7th editions.


Recurrent Childhood Ependymoma

The reemergence of ependymoma in childhood after a period of remission.


Cardiac Mesenchymal Hamartoma

A benign soft tissue mass that involves the endocardium, myocardium, or epicardium. It is characterized by the presence of an admixture of mature mesenchymal tissues normally found within the heart.


Resectable Malignant Bone Neoplasm

Malignant bone neoplasm that is amenable to surgical resection.


Vascular Access Complication

Complications related to damage at the vascular access site. Examples include bleeding, formation of hematoma, aneurysm, pseudoaneurysm, or arteriovenous fistula, development of infection, and catheter thrombosis.


Distantly Metastatic Malignant Neoplasm

A malignant tumor that has spread from its original (primary) site of growth to another site distant from the primary site.


Stage IA Gastric Carcinoma

Stage IA includes: T1, N0, M0.  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Biliary Adenofibroma

A rare benign neoplasm that arises from the intrahepatic bile ducts.  It is characterized by the presence of biliary epithelial tissue and fibroblastic stroma.


Recurrent Acute Leukemia of Ambiguous Lineage

The reemergence of acute leukemia of ambiguous lineage after a period of remission.


Metastatic Intracranial Malignant Neoplasm

An intracranial malignant neoplasm that has spread from its original site of growth to another anatomic site.


Stage I Liver Carcinoma

Stage I carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Iatrogenic Obesity

Obesity resulting from medical treatment or intervention.


Immunosuppressive Disorder

A disorder in which immune function is suppressed.


FNCLCC Sarcoma Grade 2

A sarcoma with a total score of 4 or 5 according to the FNCLCC guidelines.


Rare Childhood Malignant Neoplasm

An infrequent malignant neoplasm that occurs during childhood.


Recurrent Childhood Astrocytic Tumor

The reemergence of a childhood astrocytic tumor after a period of remission.


Advanced Biliary Tract Carcinoma

Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread extensively to other anatomic sites or is no longer responding to treatment.


Thyroid-Binding Globulin Deficiency

Subnormal concentration of thyroid-binding globulin.


Malignant melanoma in precancerous melanosis

A melanoma arising from an atypical intraepithelial melanocytic hyperplasia.


Malignant Neoplasm with Regional Lymph Node Involvement

A malignant neoplasm that has spread to nearby lymph nodes.


Stage I Esophageal Cancer AJCC v7

Stage I includes: For squamous cell carcinoma: IA (T1, N0, M0, G1, GX, Tumor location: Any); IB (T1, N0, M0, G2-3, Tumor location: Any); (T2-3, N0, M0, G1, GX, Tumor location: Lower, X).  For adenocarcinoma: IA (T1, N0, M0, G1-2, X); IB (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Skin Squamous Cell Carcinoma with Osteoclast-Like Giant Cells

A rare squamous cell carcinoma of the skin characterized by the presence of multinucleated non-neoplastic giant cells that resemble osteoclasts.


Job Strain

Negative physical or emotional health outcomes resulting from high job demands with low job decision latitude.


Stage IA Uterine Corpus Cancer AJCC v7

Stage IA includes: T1a, N0, M0.  T1a: Tumor limited to the endometrium or invades less than one-half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Hodgkin's disease mixed cellularity stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Early Rheumatoid Arthritis

Recent diagnosis of rheumatoid arthritis (usually within one to two years of onset) during which treatment may be more effective and possibly improve the disease course.


Hepatocellular carcinoma characterized by the presence of steatohepatitis features, including macrovesicular steatosis, fibrosis, ballooning of malignant hepatocytes, Mallory bodies, and inflammation.


Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Astler-Coller A Rectal Carcinoma

Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.)


Condyloma acuminata of cervix

A benign neoplasm that arises from the cervix. It is associated with human papillomavirus infection and is characterized by the presence of papillary structures with fibrovascular cores. The papillary structures are covered with stratified squamous epithelium. Koilocytosis is usually present.


Locally Advanced Urethral Urothelial Carcinoma

A urethral urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage I Bone Sarcoma AJCC v7

Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Stage IIIA2 Fallopian Tube Cancer AJCC v8

Stage IIIA2 includes: T3a, N0/N1, M0. T3a: T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)