Sinonasal Cancer by AJCC v8 Stage

A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 8th edition.


Metastatic Oral Cavity Carcinoma

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A carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


Ghost Cell Odontogenic Carcinoma

A carcinoma usually arising from the maxilla and less often the mandible.  Symptoms include swelling and paresthesia.  It is characterized by the presence of rounded islands of malignant epithelial cells in a fibrous stroma and the benign features of calcifying cystic odontogenic tumor.  The clinical course varies from slow growing and locally invasive to rapidly growing and highly aggressive with metastases.


Minor Salivary Gland Small Cell Neuroendocrine Carcinoma

An infrequent small cell carcinoma that arises from a minor salivary gland. It is characterized by the presence of neuroendocrine differentiation and a high number of mitotic figures.


Recurrent Salivary Gland Cancer

The reemergence of salivary gland carcinoma after a period of remission.


Stage IVC Nasal Cavity and Paranasal Sinus Cancer AJCC v7

Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Childhood Nasal Cavity Carcinoma

A rare carcinoma of the nasal cavity that occurs during childhood.


Metastatic Lip Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the lip and has metastasized to another anatomic site.


Advanced Salivary Gland Carcinoma

Salivary gland carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Paranasal Sinus Carcinoma

Paranasal sinus carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IVA Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage 0 Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Locally Advanced Head and Neck Squamous Cell Carcinoma

A head and neck squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Paranasal Sinus Keratinizing Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the paranasal sinuses and is characterized by prominent production of keratin.


Platinum-Resistant Head and Neck Carcinoma

Head and neck carcinoma that is resistant to platinum therapy.


Stage III Nasal Cavity Cancer AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Tumor restricted to any one subsite, with or without bony invasion.  T2: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Metastatic Lip and Oral Cavity Carcinoma

A carcinoma that arises from the lip and/or oral cavity and has metastasized to another anatomic site.


Recurrent Lip and Oral Cavity Squamous Cell Carcinoma

The reemergence of lip and oral cavity squamous cell carcinoma after a period of remission.


Low Grade Salivary Gland Carcinoma

A salivary gland carcinoma with low grade histopathologic features.  It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, and low grade salivary gland mucoepidermoid carcinoma.  It usually follows a non-aggressive clinical course.


Stage IVB Lip and Oral Cavity Cancer AJCC v8

Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases the internal carotid artery. N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE (-); or in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. (AJCC 8th Ed.)


Head and Neck Keratinizing Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the head and neck region and is characterized by prominent production of keratin.


Unresectable Salivary Gland Carcinoma

Salivary gland carcinoma that is not amenable to surgical resection.


Locally Advanced Lip and Oral Cavity Carcinoma

Lip and oral cavity carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IVC Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7


Stage IVC Sinonasal Squamous Cell Carcinoma AJCC v7

Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Low Grade Salivary Gland Mucoepidermoid Carcinoma

A salivary gland mucoepidermoid carcinoma with low grade histopathologic features.  It usually follows a non-aggressive clinical course.


Recurrent Lip Basal Cell Carcinoma

Reemergence of basal cell carcinoma of the lip after a period of remission.


Stage IV Sinonasal Squamous Cell Carcinoma AJCC v7

Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Stage II Oral Cavity Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Metastatic Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


Stage II Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage II Sinonasal Squamous Cell Carcinoma AJCC v6 and v7

Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th ed.)


Minor Salivary Gland Acinic Cell Carcinoma

An adenocarcinoma with serous acinar cell differentiation that arises from the minor salivary glands.


Stage II Nasal Cavity Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0.  T2: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Head and Neck Heterotopia-Associated Carcinoma

A head and neck carcinoma arising from heterotopic tissue elements (i.e. histologically normal tissue of a particular type that is present at an abnormal anatomical site). (WHO 2017)


Stage 0 Lip and Oral Cavity Cancer AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Ameloblastic Carcinoma-Secondary Type (Dedifferentiated), Intraosseous

A very rare ameloblastic carcinoma that originates from a pre-existing intraosseous benign ameloblastoma.


Head and neck cancer metastatic

A carcinoma that arises from the head and neck and has spread from the original site of growth to another anatomic site.


Locally Advanced Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that has spread to nearby tissues or lymph nodes.


Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck

The reemergence of cutaneous squamous cell carcinoma of the head and neck after a period of remission.


Stage I Lip and Oral Cavity Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Adenocarcinoma

Adenocarcinomas that arises from the sinonasal tract. This category includes salivary-type and non-salivary type adenocarcinomas. The latter includes intestinal-type and non-intestinal-type adenocarcinomas.


Stage IVA Sinonasal Squamous Cell Carcinoma AJCC v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Keratinizing Primary Intraosseous Squamous Cell Carcinoma-Solid Type

A squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, keratin production, infiltration of the marrow spaces, and osseous resorption.


Posterior Tongue Adenoid Cystic Carcinoma

An adenoid cystic carcinoma arising from the minor salivary glands in the base of the tongue.


Stage IVC Oral Cavity Cancer AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


adenocarcinoma of oral cavity

An adenocarcinoma that arises from the oral cavity.


Sinonasal Adenocarcinoma, Salivary-Type

Adenocarcinomas that arise from the seromucinous glands and surface epithelium of the nasal cavity and paranasal sinuses. These adenocarcinomas morphologically resemble the adenocarcinomas that arise from the major and minor salivary glands.


Stage IVA Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Hard Palate Mucoepidermoid Carcinoma

A mucoepidermoid carcinoma arising from the minor salivary glands in the hard palate.


Stage II Lip and Oral Cavity Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


Locally Advanced Salivary Gland Carcinoma

A salivary gland carcinoma that has spread to nearby tissues or lymph nodes.


Adult Salivary Gland Carcinoma

A carcinoma of the salivary gland that occurs during adulthood.


Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v6

Stage IV maxillary sinus cancer: Stage IV is divided into stages IVA, IVB, and IVC.  Stage IVA: cancer has spread to either one lymph node on the same side of the neck as the cancer and the lymph node is larger than 3 centimeters but smaller than 6 centimeters; or, cancer has spread to more than one lymph node anywhere in the neck, and all are 6 centimeters or smaller; cancer is also found in any of the following areas: the maxillary sinus, bones around the maxillary sinus, tissues under the skin, the eye socket, the base of the skull, and the ethmoid sinuses or cancer is found in one or more lymph nodes in the neck, none larger than 6 centimeters, and in any of the following areas: the front of the eye, the skin of the cheek, the base of the skull, behind the jaw, the bone between the eyes, and the sphenoid or frontal sinuses. Stage IVB: cancer has spread to either: one or more lymph nodes larger than 6 centimeters; or the back of the eye, the brain, the base and middle parts of the skull, nerves in the head, and/or the upper part of the throat behind the nose; cancer may also be found in one or more lymph nodes. Stage IVC: cancer has spread to other parts of the body.  Stage IV nasal cavity and ethmoid sinus cancer: Stage IV is divided into stages IVA, IVB, and IVC.  Stage IVA: cancer has spread to either one lymph node on the same side of the neck as the cancer and the lymph node is larger than 3 centimeters but smaller than 6 centimeters; or, cancer has spread to more than one lymph node anywhere in the neck, and all are 6 centimeters or smaller; cancer is also found in any of the following places: the nasal cavity or ethmoid sinus., the eye socket, the maxillary sinus, the roof of the mouth, and the bone between the eyes or cancer is found in one or more lymph nodes in the neck, and the lymph nodes are 6 centimeters or smaller; cancer is also found in any of the following areas: the front of the eye, the skin of the nose or cheek, front parts of the skull, the base of the skull, and the sphenoid or frontal sinuses.  Stage IVB: cancer is found in any of the following areas: the back of the eye, the brain, the middle parts of the skull, nerves in the head the upper part of the throat behind the nose and the base of the skull.  Cancer may also be found in one or more lymph nodes or cancer is found in a lymph node that is larger than 6 centimeters.  Stage IVC: cancer has spread to other parts of the body (from PDQ).


Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip and oral cavity cancer with moderately advanced local disease. Lip: Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. Oral cavity: Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Lip and Oral Cavity Cancer AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Unresectable Sinonasal Squamous Cell Carcinoma

Sinonasal squamous cell carcinoma that is not amenable to surgical resection.


anaplastic carcinoma of salivary gland

A salivary gland carcinoma characterized by the presence of undifferentiated, anaplastic malignant epithelial cells.


Sinonasal Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from the nasal cavity and paranasal sinuses.


Unresectable Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that is not amenable to surgical resection.


Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that has spread from the original site of growth to another anatomic site.


Stage I Paranasal Sinus Cancer

Stage I includes: T1, N0, M0.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Cancer by AJCC v6 Stage

A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 6th edition.


Metastatic Oral Cavity Mucoepidermoid Carcinoma

A mucoepidermoid carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


Carcinoma in situ of middle ear

An intraepithelial carcinoma of the middle ear without evidence of invasion.


adenoid cystic carcinoma of floor of mouth

An adenoid cystic carcinoma of the oral cavity that arises from the floor of the mouth.


Salivary Gland Poorly Differentiated Carcinoma

A high-grade carcinoma that arises from the salivary glands. This category includes large and small cell types with or without neuroendocrine differentiation.


Low Grade Papillary Schneiderian Carcinoma

A rare sinonasal carcinoma characterized by the presence of a papillary architecture and bland morphological features similar to the Schneiderian papilloma, a pushing pattern of stromal invasion, and an increased risk of local recurrence.


Adenoid cystic carcinoma of the oral cavity recurrent

The reemergence of adenoid cystic carcinoma in the oral cavity after a period of remission.


Stage IV Oral Cavity Cancer AJCC v6 and v7

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: (oral cavity) Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Recurrent Oral Cavity Carcinoma

The reemergence of carcinoma in the oral cavity after a period of remission.


Recurrent Paranasal Sinus Squamous Cell Carcinoma

The reemergence of paranasal sinus squamous cell carcinoma after a period of remission.


Stage I Nasal Cavity and Paranasal Sinus Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Lip and Oral Cavity Cancer AJCC v6 and v7

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  T4a (oral cavity): Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Localized Head and Neck Carcinoma

Head and neck carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


Sinonasal Adenocarcinoma, Intestinal-Type with Mixed Pattern

An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a mixture of growth patterns.


Mucoepidermoid carcinoma of the oral cavity recurrent

The reemergence of mucoepidermoid carcinoma in the oral cavity after a period of remission.


Intermediate Grade Salivary Gland Mucoepidermoid Carcinoma

A salivary gland mucoepidermoid carcinoma with intermediate grade histopathologic features.


Squamous cell carcinoma of the oral cavity stage IV


Primary Intraosseous Squamous Cell Carcinoma-Solid Type

A non-keratinizing or keratinizing squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, infiltration of the marrow spaces, and osseous resorption.


Adenoid cystic carcinoma of the tongue

An adenoid cystic carcinoma arising from the minor salivary glands in the tongue.


Recurrent Head and Neck Carcinoma

The reemergence of carcinoma in the head and neck region after a period of remission.


Cutaneous Squamous Cell Carcinoma of the Head and Neck

A squamous cell carcinoma that arises from the skin of the head and neck.


Stage I Lip Carcinoma

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Salivary Gland Oncocytic Carcinoma

A high grade adenocarcinoma that arises from the salivary glands. The vast majority of cases have been described in the parotid gland.  It is characterized by the presence of malignant oncocytes.  It recurs and metastasizes to regional or distant anatomic sites.


Stage IVA Paranasal Sinus Cancer AJCC v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses.  Ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Refractory Head and Neck Carcinoma

A head and neck carcinoma that does not respond to treatment.


Recurrent Sinonasal Carcinoma

The reemergence of nasal cavity or paranasal sinus carcinoma after a period of remission.


Head and Neck NUT Carcinoma

A highly aggressive, poorly differentiated carcinoma that arises from the head and neck. Most cases are in the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene.


Minor Salivary Gland Squamous Cell Carcinoma

A squamous cell carcinoma that affects the minor salivary glands.


Stage IVA Lip and Oral Cavity Cancer AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip and oral cavity cancer with moderately advanced local disease.  Lip: Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  Oral cavity: Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


High Grade Salivary Gland Mucoepidermoid Carcinoma

A salivary gland mucoepidermoid carcinoma with high grade histopathologic features.  It usually follows an aggressive clinical course.


Stage IVB Sinonasal Squamous Cell Carcinoma AJCC v7

Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Adenocarcinoma of salivary gland

An adenocarcinoma arising from the salivary gland.  It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland oncocytic carcinoma, salivary gland mucinous adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, salivary gland cystadenocarcinoma, salivary gland basal cell adenocarcinoma, salivary gland acinic cell carcinoma, salivary duct carcinoma, and salivary gland adenocarcinoma not otherwise specified.


Recurrent Minor Salivary Gland Adenocarcinoma

The reemergence of minor salivary gland adenocarcinoma after a period of remission.


Stage IV Nasal Cavity Cancer

Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Stage IVB Paranasal Sinus Cancer AJCC v7


Stage II Paranasal Sinus Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage III Nasal Cavity and Paranasal Sinus Cancer AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Squamous cell carcinoma of the oral cavity stage II

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage III Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Small Cell Neuroendocrine Carcinoma

A very rare small cell neuroendocrine carcinoma that arises from the nose and paranasal sinuses.


Squamous cell carcinoma of the oral cavity stage III


Stage II Nasal Cavity and Paranasal Sinus Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


ASPH-Positive Head and Neck Squamous Cell Carcinoma

A head and neck squamous cell carcinoma in which the malignant cells are positive for ASPH gene.


Sinonasal Keratinizing Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the mucosal epithelium of the nasal cavity or the paranasal sinuses and is characterized by prominent production of keratin.


Stage IVC Nasal Cavity and Paranasal Sinus Cancer AJCC v8

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (Any T, N3, M0); (T4, Any N, M0); (Any T, Any N, M1). T1: Tumor smaller than 2 cm in greatest dimension. T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. T3: Tumor 4 cm or larger in greatest dimension or minor bone erosion or perineural invasion or deep invasion. Deep invasion is defined as invasion beyond the subcutaneous fat or larger than 6 mm; perineural invasion for T3 classification is defined as tumor cells within the nerve sheath of a nerve lying deeper than the dermis or measuring 0.1 mm or larger in caliber, or presenting with clinical or radiographic involvement of named nerves without skull base invasion or transgression. T4: Tumor with gross cortical bone/marrow, skull base invasion and/or skull base foramen invasion. N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-).  N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes, any with ENE(+). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Sinonasal Lymphoepithelial Carcinoma

A nonkeratinizing squamous cell carcinoma arising from the sinonasal tract. It is characterized by the presence of large cells with vesicular nuclei and prominent nucleoli, a syncytial growth pattern, and a lymphoplasmacytic infiltrate.


Stage I Oral Cavity Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage II Lip and Oral Cavity Cancer AJCC v6 and v7


Locally Advanced Oral Cavity Carcinoma

Oral cavity carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IVA Lip Cancer AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip cancer with moderately advanced local disease.  Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Minor Salivary Gland Mucoepidermoid Carcinoma

A carcinoma that arises from the minor salivary glands.  It usually presents as a firm and painless mass.  It is characterized by the presence of epidermoid cells, mucus producing cells, and cells of intermediate type.  The majority of cases have a favorable outcome.


Stage IV Lip and Oral Cavity Cancer AJCC v8

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone or involves the inferior alveolar nerve, floor of mouth, or skin of face (i.e., chin or nose).  T4a (oral cavity): Tumor invades adjacent structures only (e.g., through cortical bone of the mandible or maxilla, or involves the maxillary sinus or skin of face). Note: Superficial erosion of bone/tooth socket (alone) by a gingival primary is not sufficient to classify a tumor as T4. T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI. T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI. T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases the internal carotid artery. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE (-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension, ENE(-). N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE (-); or in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th Ed.)


Salivary Gland Poorly Differentiated Squamous Cell Carcinoma

A poorly differentiated squamous cell carcinoma arising from the salivary gland.


Anterior Tongue Carcinoma

A carcinoma that arises from the anterior two-thirds of the tongue.  Representative examples include squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.


Locally Advanced Sinonasal Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the nasal cavity and/or paranasal sinuses and has spread from its original site of growth to nearby tissues or lymph nodes.


Stage III Paranasal Sinus Cancer AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Adenoid cystic carcinoma of the oral cavity stage IV


Salivary Gland Clear Cell Carcinoma

A carcinoma that arises from the salivary glands, most often the minor salivary glands.  It is characterized by the presence of a monomorphic population of malignant epithelial cells with clear cytoplasm and the absence of morphologic features that define other primary neoplasms of the salivary glands.


Unresectable Salivary Gland Squamous Cell Carcinoma

Salivary gland squamous cell carcinoma that is not amenable to surgical resection.


Stage II Nasal Cavity and Paranasal Sinus Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th ed.)


Anterior Tongue Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the anterior two-thirds of the tongue.  It usually presents as a painful ulcerated or nodular lesion.


Minor Salivary Gland Undifferentiated Carcinoma

A carcinoma that affects the minor salivary glands and is characterized by the presence of undifferentiated, anaplastic malignant epithelial cells.


Sinonasal Adenocarcinoma, Intestinal-Type with Colonic Pattern

An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a tubuloglandular growth pattern.


Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v8

Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1). T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses. Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses. T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve (V2), nasopharynx, or clivus. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes , none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral nodes, any with ENE(+). M0: No distant metastasis. M1: Distant metastasis.  (AJCC 8th ed.)


Stage IVC Lip and Oral Cavity Cancer AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Ameloblastic Carcinoma-Secondary Type (Dedifferentiated)

A very rare ameloblastic carcinoma that originates from a pre-existing benign ameloblastoma.


Stage IVB Nasal Cavity and Paranasal Sinus Cancer AJCC v8

Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0). T4b: Very advanced local disease. Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve (V2), nasopharynx, or clivus. N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral nodes, any with ENE(+). M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Lip Carcinoma

A carcinoma that arises from the lip and has metastasized to another anatomic site.


Adenoid cystic carcinoma of the oral cavity stage I

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


lymphoepithelial squamous cell carcinoma of salivary gland

A rare carcinoma that arises from the salivary glands, most often the parotid gland.  It is characterized by the presence of an undifferentiated carcinomatous component associated with a prominent reactive lymphoplasmacytic infiltrate.


cystadenocarcinoma of salivary gland

A rare, low-grade adenocarcinoma that arises from the salivary glands.  It presents as a slow growing asymptomatic mass and is characterized by the presence of multiple cystic spaces.


Human Papillomavirus-Related Mucosal Head and Neck Squamous Cell Carcinoma

A squamous cell carcinoma associated with human papilloma virus, arising from the mucosal sites of head and neck.


Salivary Gland Adenocarcinoma, Not Otherwise Specified

An adenocarcinoma that arises from the salivary glands.  It exhibits ductal differentiation but lacks any of the morphologic features that characterize the other well-defined primary adenocarcinomas of the salivary glands.


Metastatic Sinonasal Squamous Cell Carcinoma

Nasal cavity and/or paranasal sinus squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


Mucoepidermoid carcinoma of the oral cavity stage II

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Adenocarcinoma, Intestinal-Type with Solid Pattern

An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a solid growth pattern.


High Grade Salivary Gland Carcinoma

A usually aggressive salivary gland carcinoma with high grade histopathologic features.  It includes the salivary duct carcinoma, salivary gland oncocytic carcinoma, and high grade salivary gland mucoepidermoid carcinoma.


Alveolar Ridge Squamous Cell Carcinoma

Squamous cell carcinoma arising from the upper or lower alveolar ridge.


Unresectable Head and Neck Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the head and neck region and is not amenable to surgical resection.


Ameloblastic Carcinoma-Secondary Type (Dedifferentiated), Peripheral

A very rare ameloblastic carcinoma that originates from a pre-existing extraosseous benign ameloblastoma.


Stage IVC Lip and Oral Cavity Cancer AJCC v8

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th Ed.)


Stage IV Lip Cancer AJCC v6 and v7

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Stage III Nasal Cavity and Paranasal Sinus Cancer AJCC v8

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


Head and Neck Basaloid Carcinoma

A high-grade, aggressive variant of squamous cell carcinoma that arises from the head and neck region.  The most common sites of origin are pyriform sinus, epiglottis, and base of tongue.  It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.  Comedonecrosis may be present.


Metastatic Oral Cavity Adenoid Cystic Carcinoma

An adenoid cystic carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


Stage 0 Paranasal Sinus Cancer AJCC v6, v7, and v8

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th, 7th, and 8th eds.)


Salivary Gland Myoepithelial Carcinoma

A locally aggressive carcinoma that arises from the salivary glands, predominantly the parotid gland. It is characterized by the presence of a malignant cellular infiltrate exhibiting myoepithelial differentiation. Patients usually present with a painless mass.


Stage 0 Sinonasal Cancer AJCC v6, v7, and v8


Posterior Tongue Mucoepidermoid Carcinoma

A mucoepidermoid carcinoma arising from the minor salivary glands in the base of the tongue.


Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Mucoepidermoid carcinoma of the tongue

A mucoepidermoid carcinoma that arises from the tongue.


Odontogenic Carcinoma

A carcinoma that arises from tooth-forming tissues.


Palate carcinoma

A carcinoma that arises from the hard or soft palate.  Representative examples include squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.


Squamous cell carcinoma of the oral cavity recurrent

Reemergence of squamous cell carcinoma of the oral cavity after a period of remission.


Stage III Sinonasal Squamous Cell Carcinoma AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Non-Keratinizing Primary Intraosseous Squamous Cell Carcinoma -Solid Type

A squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, lack of prominent keratinization, infiltration of the marrow spaces, and osseous resorption.


Sinonasal Cancer by AJCC v7 Stage

A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 7th edition.


Stage III Lip Cancer AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Salivary Gland Neuroendocrine Carcinoma

A high-grade neuroendocrine carcinoma that arises from the salivary glands. This category includes small cell and large cell neuroendocrine carcinoma.


Stage IVA Nasal Cavity and Paranasal Sinus Cancer AJCC v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Lip and Oral Cavity Cancer AJCC v8

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI. T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE (extranodal extension)(-). M0: No distant metastasis. (AJCC 8th Ed.)


Recurrent Salivary Gland Squamous Cell Carcinoma

The reemergence of salivary gland squamous cell carcinoma after a period of remission.


Cribriform Adenocarcinoma of Minor Salivary Gland

A minor salivary gland adenocarcinoma characterized by a cribriform pattern. It often metastasizes to the neck lymph nodes.


Refractory Salivary Gland Carcinoma

Salivary gland carcinoma that is resistant to treatment.


Salivary Gland Intraductal Carcinoma

A rare, low-grade adenocarcinoma that arises from the salivary glands.  It is characterized by the presence of cystic structures lined by ductal cells which are arranged in cribriform patterns.  Adjacent ducts show intraductal proliferation.


Stage IVC Paranasal Sinus Cancer AJCC v7

Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Stage I Nasal Cavity and Paranasal Sinus Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Locally Advanced Head and Neck Carcinoma

A head and neck carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Recurrent Head and Neck Squamous Cell Carcinoma

The reemergence of squamous cell carcinoma in the head and neck region after a period of remission.


basaloid squamous cell carcinoma of floor of mouth

An aggressive variant of squamous cell carcinoma that arises from the floor of the mouth. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.


Mucoepidermoid carcinoma of the oral cavity stage III


Primary Intraosseous Squamous Cell Carcinoma Derived From Odontogenic Cyst

A rare squamous cell carcinoma that arises centrally from the jaw from the lining of an odontogenic cyst.


large cell neuroendocrine carcinoma of salivary gland

A large cell carcinoma that arises from the salivary glands and exhibits neuroendocrine differentiation.


Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v7

Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Head and Neck Neuroendocrine Carcinoma

A rare neuroendocrine carcinoma that arises from the head and neck.


Mucoepidermoid carcinoma of the oral cavity stage I

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Clear cell odontogenic carcinoma

A usually aggressive malignant neoplasm arising from tooth-forming tissues. It more often affects older females and more frequently occurs in the mandible. It is characterized by the presence of malignant epithelial cells with clear cytoplasm and a fibrotic stroma formation. It may recur and metastasize. Metastases may occur in the lymph nodes, lungs, and bones. Treatment of choice is resection with clean margins.


Sinonasal Adenocarcinoma, Intestinal-Type with Mucinous Pattern

An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of malignant glandular cells with intracytoplasmic mucin.


Primary ameloblastic carcinoma

A rare, aggressive odontogenic malignant tumor that arises usually from the mandible and less frequently from the maxilla.  It combines the histologic features of an ameloblastoma and carcinoma.


Childhood Salivary Gland Carcinoma

A rare carcinoma of the salivary gland that occurs during childhood.


Lip and Oral Cavity Cancer by AJCC v8 Stage

A term that refers to the staging of lip and oral cavity carcinoma according to the American Joint Committee on Cancer, 8th edition.


Stage III Oral Cavity Cancer AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor smaller than 2 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Adenoid cystic carcinoma of the oral cavity

An adenoid cystic carcinoma arising from the minor salivary glands in the oral cavity.


Polymorphous low grade adenocarcinoma of salivary gland

A low grade malignant epithelial neoplasm arising from the salivary gland. It usually arises from the oral cavity, with approximately 60% of the cases involving the palate. The most common presenting sign is a painless mass in the palate. It is characterized by the presence of uniform, small to medium size malignant epithelial cells and an infiltrating pattern. There is a variety of morphologic patterns which may be present within an individual tumor, including lobular, papillary, papillary-cystic, cribriform, and trabecular pattern. It usually has a favorable clinical outcome and a low metastatic potential.


Anterior Tongue Mucoepidermoid Carcinoma

A mucoepidermoid carcinoma arising from the minor salivary glands in the anterior tongue.


Ear carcinoma

A carcinoma that arises from the ear.  Representative examples include ceruminous adenocarcinoma and squamous cell carcinoma of the external ear and adenocarcinoma of the middle ear.


Head and Neck Small Cell Neuroendocrine Carcinoma

A small cell neuroendocrine carcinoma that arises from the head and neck.


Stage IVA Nasal Cavity and Paranasal Sinus Cancer AJCC v8

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses. Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes , none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


plasma membrane proton-transporting ATP synthase, stator stalk

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species.


proton-transporting ATP synthase, stator stalk

One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core.


mitochondrial proton-transporting ATP synthase, stator stalk

One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.


trans-Stilbene

Any olefinic compound characterised by a 1,2-diphenylethylene backbone.


iminium ion

Cations of structure R2C=N(+)R2.


Cutaneous Indeterminate Dendritic Cell Tumor

A very rare dendritic cell tumor affecting the skin. It is composed of spindle to ovoid cells with a phenotype that is similar to the Langerhans cells. It manifests with cutaneous papules, nodules, and plaques.  The clinical course is variable.


small intestine venule

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Venule of villus of small intestine.


uterine epithelium

An epithelium that is part of a uterus.


epithelium of uterine horn

An epithelium that is part of a uterine horn [Automatically generated definition].


cervical squamo-columnar junction

Region of cervical epithelium where columnar epithelium of endocervic and the stratified non-keratinising squamous epithelium of the ectocervic meet.


ectocervical epithelium

An epithelium that is part of a ectocervix.


endometrium epithelium

An epithelium that is part of an endometrium [Automatically generated definition].


outer layer of endometrium

The layer of endometrial epithelium adjacent to the myometrium.


basal layer of endometrium

The layer of endometrial epithelium adjacent to the uterine cavity.


rhabdomere membrane

The portion of the plasma membrane surrounding the rhabdomere.


Atypical Ductal Breast Hyperplasia

A neoplastic process that arises from the terminal ductal lobular unit of the breast parenchyma.  It is usually solitary and confined to a single lobular unit.  It is characterized by the presence of a monomorphic epithelial proliferation in a cribriform, micropapillary, or solid growth pattern.  Focal architectural features of low grade ductal carcinoma in situ are present.  There is an increased risk for development of invasive breast carcinoma.


Seminal Vesicle Angiosarcoma

An extremely rare angiosarcoma that affects the seminal vesicle.


Stage IVA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IVA includes: T4, Any N, M0. T4: Uterine corpus endometrial stroma sarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Benign fibrohistiocytic neoplasm of skin

A benign neoplasm arising from the skin. It is composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes arranged in a storiform pattern.


Central Nervous System Solitary Fibrous Tumor

A mesenchymal, non-meningothelial neoplasm arising from the central nervous system. It is characterized by a collagenous and low cellularity spindle cell and/or hemangiopericytomatous histopathological pattern, recurrent intrachromosomal rearrangement on chromosome 12q that results in the fusion of the NAB2 and STAT6 genes, high recurrence rates, and long-term risk of systemic metastasis.


Extraskeletal osteosarcoma recurrent

The reemergence of extraskeletal osteosarcoma after a period of remission.


Digestive System Kaposi Sarcoma

A Kaposi sarcoma arising from the digestive system.


Dermatomyofibroma

A rare benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation. (WHO 2018)


Giant Cell Angiofibroma

A morphologic variant of angiofibroma characterized by the presence of multinucleated giant cells, collagenous or myxoid stroma, focal sclerotic areas, and angiectoid spaces.


Prostate Osteosarcoma

A rare osteosarcoma that arises from the prostate gland.


Parotid Gland Nodular Fasciitis

A self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the parotid gland. It is composed of fibroblastic/myofibroblastic cells.


Resectable Undifferentiated Pleomorphic Sarcoma

Undifferentiated pleomorphic sarcoma that is amenable to surgical resection.


Oral Cavity Leiomyoma

A benign smooth muscle neoplasm arising from the oral cavity. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.


Central Nervous System Myofibroblastoma

A rare myofibroblastoma affecting the central nervous system.


Gastrointestinal Stromal Tumor of the Gastrointestinal Tract

A stromal tumor that originates from the interstitial cells of Cajal. It may involve any part of the gastrointestinal tract. The majority of cases occur in the stomach. Morphologic variants include the epithelioid cell type, spindle cell type, and mixed cell type. Most cases contain KIT- or PDGFRA-activating mutations. Lesions with a diameter greater than 10cm and more than 5 mitotic figures per 50HPF tend to have a more aggressive clinical course. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases.


Esophageal Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the esophagus.


Recurrent Adult Soft Tissue Sarcoma

A soft tissue sarcoma occurring in adults that has recurred after a period of remission.


Salivary Gland Nodular Fasciitis

A self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the salivary glands. It is composed of fibroblastic/myofibroblastic cells. It usually occurs in the parotid gland.


Stage II Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

Stage II includes: T3, N0, M0, Low Mitotic Rate. T3: Tumor measuring more than 5 cm but not more than 10 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Uterine Corpus Inflammatory Myofibroblastic Tumor

A rare inflammatory myofibroblastic tumor that arises from the uterine corpus.


Cellular angiofibroma

A benign mesenchymal neoplasm that usually arises in the superficial soft tissues of the vulva or inguinal and scrotal regions.  It is characterized by the presence of a cellular fibroblastic proliferation in an edematous to fibrous stroma containing numerous vessels.


Prostate Undifferentiated Pleomorphic Sarcoma

A rare undifferentiated pleomorphic sarcoma that arises from the prostate gland.


Advanced Kaposi Sarcoma

Kaposi sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


EBV-Related Sarcoma

Sarcoma that is caused by Epstein-Barr virus infection.


Benign Central Nervous System Mesenchymal, Non-Meningothelial Neoplasm

A non-metastasizing mesenchymal, non-meningothelial neoplasm that arises from the central nervous system.


Seminal Vesicle Soft Tissue Neoplasm

A mesenchymal neoplasm that arises from the seminal vesicle.


Stage II Uterine Sarcoma AJCC v7

Stage II includes: T2, N0, M0.  T2: Tumor extends beyond the uterus, within the pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


Stage II Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

Stage II includes: (T1, N0, M0, High Mitotic Rate); (T2, N0, M0, High Mitotic Rate); (T4, N0, M0, Low Mitotic Rate). T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. T4: Tumor measuring more than 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Stage IIB Adult Soft Tissue Sarcoma AJCC v7


Plaque-like CD34 positive dermal fibroma

A congenital or acquired benign dermal spindle cell neoplasm with histopathological features mimicking those of superficial dermal dermatofibrosarcoma protuberans. (WHO 2018)


Metastatic Extraskeletal Myxoid Chondrosarcoma

An extraskeletal myxoid chondrosarcoma which has spread to another anatomic site.


Bladder PEComa

A benign or malignant perivascular epithelioid cell tumor arising from the bladder.


Gastrointestinal Clear Cell Sarcoma/Malignant Gastrointestinal Neuroectodermal Tumor

A gastrointestinal tract sarcoma with neuroectodermal differentiation. It is characterized by the presence of neoplastic round cells with pale eosinophilic cytoplasm. Cytoplasmic clearing is seen only in a minority of cases. Half of the cases contain osteoclastic giant cells. It is associated with gene fusion translocations involving the EWSR1 gene, usually EWSR1-ATF1 fusion or EWSR1-CREB1 fusion.


Lacrimal Gland Myoepithelioma

A benign neoplasm with myoepithelial differentiation arising from the lacrimal gland. It lacks an infiltrative growth pattern and does not metastasize.


Uterine Corpus Smooth Muscle Neoplasm

A benign, intermediate, or malignant neoplasm that arises from the uterine corpus and is composed of neoplastic cells with smooth muscle differentiation.


Childhood Desmoplastic Small Round Cell Tumor

A desmoplastic small round cell tumor occurring in children.


Ossifying fibromyxoid tumor, malignant

An ossifying fibromyxoid tumor characterized by the presence of high grade nuclear features or increased cellularity and more than two mitotic figures per 50 HPFs.


Uterine Corpus High Grade Endometrial Stromal Sarcoma

A rare, high grade sarcoma that arises from the endometrial stroma. It is characterized by round cell morphology. It was previously also known as undifferentiated uterine sarcoma. In 2014, high grade endometrial stromal sarcoma was reclassified and is currently considered a distinct and rare neoplasm. It appears to have a prognosis that falls between low grade endometrial stromal sarcoma and undifferentiated sarcoma.


Salivary Gland Myoepithelial Tumor

A benign or malignant tumor that arises from the salivary glands.  It is characterized by the presence of neoplastic cells with myoepithelial differentiation.  This category includes benign myoepithelioma and myoepithelial carcinoma.


Vulvar Angiosarcoma

A rare angiosarcoma that arises from the vulva.


Liver and Intrahepatic Bile Duct Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the liver and intrahepatic bile ducts.


Stage IB Gastric Gastrointestinal Stromal Tumor

Stage IB includes: T3, N0, M0, Mitotic rate: Low.  T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Vulvar Soft Tissue Neoplasm

A benign or malignant mesenchymal neoplasm of the vulva.  Representative examples include leiomyoma, cellular angiofibroma, angiomyxoma, leiomyosarcoma, liposarcoma, and childhood botryoid-type embryonal rhabdomyosarcoma.


Gastric Inflammatory Myofibroblastic Tumor

A multinodular intermediate fibroblastic neoplasm arising from the stomach.  It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.


Stage III Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

Stage III includes: IIIA: (T1, N0, M0, High Mitotic Rate); (T4, N0, M0, Low Mitotic Rate); IIIB: (T2, N0, M0, High Mitotic Rate); (T3, N0, M0, High Mitotic Rate); (T4, N0, M0, High Mitotic Rate). T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. T3: Tumor measuring more than 5 cm but not more than 10 cm. T4: Tumor measuring more than 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Sinonasal Desmoid Fibromatosis

Desmoid fibromatosis that arises from the nasal cavity and paranasal sinuses.


Kaposi's sarcoma of liver

A Kaposi sarcoma that arises from the liver.


Cervical Malignant Peripheral Nerve Sheath Tumor

A rare malignant neoplasm with nerve sheath differentiation arising from the cervix.


Breast Nodular Fasciitis

A self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the breast. It has been described in both the subcutis and parenchyma of the breast. It occurs most frequently in the upper-outer quadrant. It is composed of fibroblastic/myofibroblastic cells.


Pilar-Associated Mesenchyme Neoplasm

A mesenchymal neoplasm arising from the pilar sheath of the hair follicle.


Gastric Malignant Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor arising from the stomach.  It is characterized by large size (diameter greater than 10 cm) or more than 5 mitotic figures per 50 high power fields.


Benign Sinonasal Soft Tissue Neoplasm

A non-metastasizing soft tissue neoplasm that arises from the nasal cavity and paranasal sinuses.


Stage III Soft Tissue Sarcoma AJCC v7

Stage III includes: (T2a, T2b, N0, M0, G3); (Any T, N1, M0, Any G).  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  G3: Grade 3.  There is no T2a for the pathologic group. (AJCC 7th ed.)


Fibrous tissue neoplasm of skin

A neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts.


Vulvar Angiomyxoma

A deep or superficial angiomyxoma of the vulva.  It may recur following resection.


Stage II Soft Tissue Sarcoma AJCC v7

Stage II includes: IIA (T1a, N0, M0, G2, G3); (T1b, N0, M0, G2, G3); IIB (T2a, N0, M0, G2); (T2b, N0, M0, G2).  T1a: Superficial tumor 5 cm or less in greatest dimension.  T1b: Deep tumor 5 cm or less in greatest dimension.  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G2: Grade 2.  G3: Grade 3. (AJCC 7th ed.)


Biphenotypic sinonasal sarcoma

A rare, slow-growing, low-grade soft tissue sarcoma arising from the sinonasal tract. It presents with non-specific obstructive nasal symptoms. Morphologically, it is an infiltrative, cellular spindle cell neoplasm. It is associated with rearrangement of the PAX3 gene.


Breast Inflammatory Myofibroblastic Tumor

A multinodular intermediate fibroblastic neoplasm arising from the breast.  It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells.


Bladder Benign PEComa

A benign perivascular epithelioid cell tumor arising from the bladder.


Recurrent Malignant Soft Tissue Neoplasm

Reemergence of a malignant soft tissue neoplasm after a period of remission.


Sinonasal Undifferentiated Pleomorphic Sarcoma

An undifferentiated pleomorphic sarcoma that arises from the nasal cavity and paranasal sinuses.


Locally Advanced Soft Tissue Sarcoma

Soft tissue sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Digestive System Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the digestive system.


Digestive System Lipoma

A lipoma arising from an anatomic site in the digestive system.


Prostate Solitary Fibrous Tumor

A rare solitary fibrous tumor that arises from the prostate gland.


Stage I Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage I includes: T1, N0, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


AIDS-Related Gastric Kaposi Sarcoma

A Kaposi sarcoma arising from the stomach in patients who are infected with the human immunodeficiency virus.


Vulvar Kaposi Sarcoma

A Kaposi sarcoma arising from the vulva.


Digestive System Leiomyoma

A leiomyoma arising from an anatomic site in the digestive system.


Clear-Cell Myomelanocytic Tumors

A very rare, usually benign neoplasm with perivascular epithelioid cell differentiation characterized by the presence of clear spindle cells arranged in fascicles and nests that usually affects young girls.  Patients usually present with a painful abdominal mass.


Vaginal Superficial Myofibroblastoma

An uncommon, benign, well circumscribed mesenchymal neoplasm that grows beneath the vaginal epithelium. It is characterized by the presence of cells containing bland ovoid, spindle, or stellate-shaped nuclei in a collagenous stroma.


Uterine Corpus Epithelioid Smooth Muscle Tumor of Uncertain Malignant Potential

A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and is composed of neoplastic epithelioid cells.


Vaginal Undifferentiated Sarcoma

A high grade infiltrating sarcoma that arises from the vagina. It is characterized by the presence of malignant small spindle cells with scant cytoplasm.


Prostate Soft Tissue Neoplasm

A mesenchymal neoplasm that arises from the prostate gland.


Stage I Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

Stage I includes: T1 or T2, N0, M0, Low Mitotic Rate. T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Childhood Soft Tissue Sarcoma

Soft tissue sarcoma occurring in childhood.


Atypical Lipomatous Tumor/Well Differentiated Liposarcoma of Deep Soft Tissue

An atypical lipomatous tumor/well differentiated liposarcoma that occurs in deep soft tissue.


Stage I Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

Stage I includes: IA: (T1 or T2, N0, M0, Low Mitotic Rate); IB: (T3, N0, M0, Low Mitotic Rate). T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. T3: Tumor measuring more than 5 cm but not more than 10 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Sinonasal Sarcoma

A sarcoma that arises from the nasal cavity and paranasal sinuses.


Seminal Vesicle Schwannoma

A schwannoma that affects the seminal vesicle.


Vulvar Smooth Muscle Tumor of Uncertain Malignant Potential

A smooth muscle neoplasm that arises from the vulva and cannot be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings.


Transplant-Related Kaposi Sarcoma

A Kaposi sarcoma that arises in a patient with a history of organ transplantation.


Esophageal Fibroma

A benign neoplasm arising from the fibrous soft tissue of the esophagus. It is characterized by the presence of spindle-shaped fibroblasts.


Conjunctival Stromal Tumor

A rare benign stromal tumor that arises from the bulbar conjunctiva. It is characterized by the presence of myxoid/collagenous stroma, spindle-shaped cells, pseudonuclear inclusions, and multinucleated cells.


Recurrent Uterine Corpus Sarcoma

The reemergence of uterine corpus sarcoma after a period of remission.


Kaposi's sarcoma, metastatic

Kaposi sarcoma that has spread from its original site of growth to another anatomic site.


Sinonasal Leiomyoma

A leiomyoma that arises from the nasal cavity and paranasal sinuses.


Advanced Soft Tissue Sarcoma

A sarcoma of soft tissue that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IV Gastric Gastrointestinal Stromal Tumor

Stage IV includes: (Any T, N1, M0, Mitotic rate: Any rate); (Any T, Any N, M1, Mitotic rate: Any rate). N1: Regional lymph node metastasis. M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Peritoneal Calcifying Fibrous Tumor

A benign well-circumscribed lesion arising from the mesentery. It is characterized by the presence of fibroblasts, lymphoplasmacytic infiltrates, collagenous stroma formation, psammoma bodies, and dystrophic calcifications.


Recurrent Extraskeletal Myxoid Chondrosarcoma

Reemergence of extraskeletal myxoid chondrosarcoma after a period of remission


Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential

A smooth muscle neoplasm that arises from the uterine corpus and cannot be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings.


Advanced Epithelioid Sarcoma

Epithelioid sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Soft Tissue Angiosarcoma

An angiosarcoma that arises from the soft tissues, usually in the deep muscles of the lower extremities, retroperitoneum, mediastinum, and mesentery.


Oral Cavity Soft Tissue Sarcoma

A soft tissue sarcoma that arises from the oral cavity.


Scrotal Sarcoma

A sarcoma involving the scrotum.


Malignant Epithelioid Cell Type Gastrointestinal Stromal Tumor

An epithelioid cell type gastrointestinal stromal tumor with an aggressive clinical course.


Kidney Angiosarcoma

A rare angiosarcoma arising from the kidney.


Skin Fibrous Histiocytoma, Histiocytic Variant

A morphologic variant of fibrous histiocytoma of the skin. It is characterized by the presence of xanthomatous fibrohistiocytic cells, giant cells, and hemosiderin deposition.


Desmoplastic fibroma

A rare, benign, locally aggressive osteolytic neoplasm. It is characterized by the presence of a rich collagenous stroma and spindle cells with minimal cellular atypia.


Central Nervous System Dedifferentiated Solitary Fibrous Tumor

A central nervous system solitary fibrous tumor characterized by the presence of areas of abrupt transition to high grade sarcoma.


Broad ligament leiomyoma

A leiomyoma that arises from the broad ligament.


Stage IIIB Gastric Gastrointestinal Stromal Tumor

Stage IIIB includes: T4, N0, M0, Mitotic rate: High. T4: Tumor more than 10 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Benign Skin Fibroblastic Neoplasm

A benign neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts without malignant characteristics.


Locally Advanced Undifferentiated Pleomorphic Sarcoma

An undifferentiated pleomorphic sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Desmoplastic Small Round Cell Tumor

Desmoplastic small round cell tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Paratesticular Liposarcoma

A liposarcoma that arises from the paratesticular region.


Vulvar Lipoblastoma-Like Tumor

A benign, well-defined, lobulated, myxoid or gelatinous tumor that arises from the vulva. It shares morphological features with lipoblastoma, myxoid liposarcoma, and spindle cell lipoma. It is characterized by a lobulated growth and is composed of mature adipocytes, lipoblasts, and spindle cells without atypia in a myxoid matrix. DDIT3 and PLAG1 gene rearrangements seen in lipoblastoma and myxoid liposarcoma are not present in this tumor. It can recur infrequently and there are no reports of metastasis.


Recurrent Soft Tissue Sarcoma

The reemergence of soft tissue sarcoma after a period of remission.


Uterine Corpus Endometrial Stromal and Related Neoplasms

A category of benign or malignant mesenchymal neoplasms that arises from the uterine corpus. This category includes the endometrial stromal nodule which is benign and non-invasive, the endometrial stromal sarcoma, and the undifferentiated uterine sarcoma. The endometrial stromal sarcoma is an invasive malignant neoplasm, further subdivided into low grade and high grade endometrial stromal sarcoma. Undifferentiated uterine sarcoma was previously also known as high grade endometrial stromal sarcoma. In 2014, high grade endometrial stromal sarcoma was reclassified and is currently considered a distinct and rare neoplasm. It appears to have a prognosis that falls between low grade endometrial stromal sarcoma and undifferentiated sarcoma.


Uterine Corpus Tumor Resembling Ovarian Sex Cord Tumor

A usually benign neoplasm that arises from the uterine corpus. It resembles ovarian sex cord tumors. It lacks a component of recognizable endometrial stroma and the JAZF1-SUZ12 fusion which is characteristic of the endometrial stromal neoplasms.


Breast Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the breast.


Vulvar Deep (Aggressive) Angiomyxoma

A locally infiltrating, non-metastasizing vulvar angiomyxoma.  It may recur following resection.


Peritoneal Low Grade Endometrioid Stromal Sarcoma

A very rare sarcoma that arises from the peritoneum and is characterized by the presence of cells that resemble endometrial stromal cells.


Stage IIIC Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Unresectable Epithelioid Sarcoma

Epithelioid sarcoma that is not amenable to surgical resection.


Oral Cavity Soft Tissue Neoplasm

A soft tissue neoplasm that arises from the oral cavity.


Adult Desmoplastic Small Round Cell Tumor

A desmoplastic small round cell tumor occurring in adults.


Major Salivary Gland Sarcoma

A rare malignant soft tissue neoplasm that arises from the parotid gland, submandibular gland, or sublingual gland.  Representative examples include fibrosarcoma, angiosarcoma, leiomyosarcoma, and Kaposi sarcoma.


Recurrent Kaposi Sarcoma

The reemergence of Kaposi sarcoma after a period of remission.


Peripheral Intraneural Angiosarcoma

A malignant vascular neoplasm arising from the peripheral nerves.


Endemic African Kaposi Sarcoma

A Kaposi sarcoma that occurs in adults and children in Equatorial Africa.


Stage IIB Uterine Sarcoma AJCC v7

Tumor involves other pelvic tissues.  No regional lymph node or distant metastasis.


Intermediate Fibrohistiocytic Neoplasm

A fibrohistiocytic neoplasm usually affecting younger patients.  It is characterized by an increased risk of local recurrence and a low risk of metastasis.