quinate biosynthetic process

The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid.


formate biosynthetic process

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.


methionine catabolic process to 3-methylthiopropanoate

The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.


acetate biosynthetic process from carbon monoxide

The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide.


protein deglycation, methylglyoxal removal

The removal of methylglyoxal from a glycated protein, to form lactate and a deglycated protein.


2-dehydro-3-deoxy-D-gluconic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of 2-dehydro-3-deoxy-D-gluconic acid.


p-cumate biosynthetic process

The chemical reactions and pathways resulting in the formation of p-cumate.


L(+)-lactate biosynthetic process from pyruvate

The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate.


dethiobiotin biosynthetic process

The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms.


methylgallate biosynthetic process

The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid.


mycolic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain.


positive regulation of fever generation by prostaglandin biosynthetic process

Any prostaglandin biosynthetic process process that positively_regulates fever generation.


aldonic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group.


2-oxobutyrate biosynthetic process

The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2.


butyrate biosynthetic process

The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid.


o-orsellinic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of o-orsellinic acid.


palmitic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of palmitic acid.


ochratoxin A biosynthetic process

The chemical reactions and pathways resulting in the formation of ochratoxin A.


glycyrrhetinate biosynthetic process

The chemical reactions and pathways resulting in the formation of glycyrrhetinate.


early stripe melanocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development).


late stripe melanocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development).


chronic lymphoproliferative disorder of NK-cells

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

An Epstein-Barr virus negative disorder with a chronic clinical course affecting predominantly adults and characterized by the proliferation of large granular lymphocytes with natural killer cell immunophenotype. The T-cell receptor genes are not rearranged.


UDP-N-acetylgalactosamine transmembrane transporter activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


autosomal recessive early-onset Parkinson disease 23

Any young-onset Parkinson disease in which the cause of the disease is a mutation in the VPS13C gene.


Parkinson disease 17

Any Parkinson disease in which the cause of the disease is a mutation in the VPS35 gene.


juvenile onset Parkinson disease 19A

Any Parkinson disease in which the cause of the disease is a mutation in the DNAJC6 gene.


Parkinson disease 21

Any hereditary late onset Parkinson disease in which the cause of the disease is a mutation in the DNAJC13 gene.


Kufor-Rakeb syndrome

Kufor-Rakeb syndrome (KRS) is a rare genetic neurodegenerative disorder characterized by juvenile Parkinsonism, pyramidal degeneration (dystonia), supranuclear palsy, and cognitive impairment.


autosomal recessive juvenile Parkinson disease 2

A group of disorders which feature impaired motor control characterized by bradykinesia, muscle rigidity; tremor; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see parkinson disease), secondary parkinsonism (see parkinson disease, secondary) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the basal ganglia.


early-onset Parkinson disease 20

Any Parkinson disease in which the cause of the disease is a mutation in the SYNJ1 gene.


parkinsonian-pyramidal syndrome

A Parkinson's disease that has material basis in mutation in the FBXO7 gene on chromosome 22q12.3.


late-onset Parkinson disease

A Parkinson disease that begins after around the age of 50.


autosomal dominant Parkinson disease 8

Any Parkinson disease in which the cause of the disease is a mutation in the LRRK2 gene.


autosomal recessive early-onset Parkinson disease 7

Any Parkinson disease in which the cause of the disease is a mutation in the PARK7 gene.


young-onset Parkinson disease

A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.


autosomal dominant Parkinson disease 4

A late onset Parkinson disease that has material basis in heterozygous triplication of the alpha-synuclein gene (SNCA) on chromosome 4q22.


Parkinson disease 22, autosomal dominant

Any Parkinson disease in which the cause of the disease is a mutation in the CHCHD2 gene.


autosomal recessive early-onset Parkinson disease 6

Any Parkinson disease in which the cause of the disease is a mutation in the PINK1 gene.


autosomal recessive Parkinson disease 14

A rare neurodegenerative disease usually presenting before the age of 30 and which is characterized by dystonia, L-dopa-responsive parkinsonism, pyramidal signs and rapid cognitive decline.


hymenolepiasis

A parasitic infection caused by tapeworms. Most infected individuals do not have symptoms. When symptoms appear, they include diarrhea, abdominal pain, restlessness, and irritability.


cavum principale

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The largest part of the nasal cavity, containing the olfactory epithelium.


congenital aortic valve insufficiency

Dysfunction of the aortic valve characterized by incomplete valve closure that is present at birth.


Heart valve regurgitation

Dysfunction of one of the cardiac valves characterized by incomplete valve closure.


Congenital insufficiency of pulmonary valve

Dysfunction of the pulmonary valve characterized by incomplete valve closure that is present at birth.


pyrazolylalanine synthase activity

Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O.


negative regulation of sorocarp stalk cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


positive regulation of sorocarp stalk cell differentiation

Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


lateral sinus thrombosis

Formation or presence of a blood clot (thrombus) in the lateral sinuses. This condition is often associated with ear infections (otitis media or mastoiditis) without antibiotic treatment. In developed nations, lateral sinus thrombosis can result from craniocerebral trauma; brain neoplasms; neurosurgical procedures; thrombophilia; and other conditions. Clinical features include headache; vertigo; and increased intracranial pressure.


intracranial sinus thrombosis

Formation or presence of a blood clot (thrombus) in the cranial sinuses, large endothelium-lined venous channels situated within the skull. Intracranial sinuses, also called cranial venous sinuses, include the superior sagittal, cavernous, lateral, petrous sinuses, and many others. Cranial sinus thrombosis can lead to severe headache; seizure; and other neurological defects.


cavernous sinus thrombosis

Formation or presence of a blood clot (thrombus) in the cavernous sinus of the brain. Infections of the paranasal sinuses and adjacent structures, craniocerebral trauma, and thrombophilia are associated conditions. Clinical manifestations include dysfunction of cranial nerves iii, iv, V, and vi, marked periorbital swelling, chemosis, fever, and visual loss. (From Adams et al., Principles of Neurology, 6th ed, p711)


anterior auricular lymph node

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The preauricular deep parotid lymph nodes (anterior auricular glands or preauricular glands), from one to three in number, lie immediately in front of the tragus. Their afferents drain the lateral surface of the auricula and the skin of the adjacent part of the temporal region; their efferents pass to the superior deep cervical glands.


Arteriovenous fistula stenosis

Narrowing of the lumen of an arteriovenous fistula.


Triple-Class Refractory Plasma Cell Myeloma

Plasma cell myeloma that is resistant to three classes of therapeutic agents, including proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies.


heme B transmembrane transporter activity

Enables the transfer of heme B from one side of a membrane to the other.


apocrine sweat gland disorder

A disease that involves the apocrine sweat gland.


chromhidrosis

A rare condition characterized by the secretion of colored sweat, caused by the deposition of lipofuscin in the sweat glands. Usually chromhidrosis affects the apocrine glands, mainly on the face and underarms.


familial acne inversa

An instance of hidradenitis suppurativa that is caused by an inherited modification of the individual's genome.


acne inversa, familial, 3

Any familial acne inversa in which the cause of the disease is a mutation in the PSEN1 gene.


acne inversa, familial, 2

Any familial acne inversa in which the cause of the disease is a mutation in the PSENEN gene.


apocrine adenoma

A benign epithelial neoplasm arising from the apocrine sweat glands. Representative examples include tubular apocrine adenoma and external auditory canal ceruminous adenoma.


apocrine sweat gland cancer

A malignant neoplasm involving the apocrine sweat gland.


acne inversa, familial, 1

Any familial acne inversa in which the cause of the disease is a mutation in the NCSTN gene.


apocrine sweat gland neoplasm

A benign or malignant sweat gland neoplasm with apocrine differentiation. Representative examples include apocrine adenoma, ceruminous adenocarcinoma, and apocrine breast carcinoma.


negative regulation of cholangiocyte proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation.


regulation of cholangiocyte proliferation

Any process that modulates the frequency, rate or extent of cholangiocyte proliferation.


negative regulation of nucleoside transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


negative regulation of adenosine transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


negative regulation of purine nucleoside transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


negative regulation of inosine transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


Dextrocardia Situs Solitus

A congenital heart defect in which the heart is located in the right side and the other organs are in their normal position.


negative regulation of octopamine signaling pathway involved in response to food

Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food.


negative regulation of octopamine signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway.


Recurrent Childhood Pineoblastoma

The reemergence of pineoblastoma in childhood after a period of remission.


Trichomonas prostatitis

Infection of the prostate gland caused by Trichomonas vaginalis.


detection of light stimulus involved in magnetoreception

The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field.


Blasts 9 Percent or Less of Peripheral Blood White Cells

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

A semi-quantitative microscopic finding indicating that 9 percent or less of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.


Renal Tubular Acidosis Associated With Deafness

Renal tubular acidosis associated with sensorineural hearing loss, and which is typically associated with recessive mutations.


extracellular sequestering of iron ion

The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system.


Refractory Chronic Myelomonocytic Leukemia

Chronic myelomonocytic leukemia that is resistant to treatment.


tRNA-dihydrouridine47 synthase activity

Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) = H+ + a uracil47 in tRNA + NAD(P)H.


myosin II light chain binding

Binding to a light chain of a myosin II complex.


Wilson-Turner syndrome

A very rare genetic disease characterized by intellectual disability, truncal obesity, gynecomastia, hypogonadism, dysmorphic facial features, and short stature.


myasthenic syndrome, congenital, 1B, fast-channel

A congenital myasthenic syndrome characterized by defects in postsynaptic neuromuscular junctions with early-onset progressive muscle weakness that has material basis in mutation in the CHRNA1 gene on chromosome 2q.


autosomal recessive congenital ichthyosis 3

Any autosomal recessive congenital ichthyosis in which the cause of the disease is a mutation in the ALOXE3 gene.


autosomal recessive congenital ichthyosis 4B

Harlequin ichthyosis (HI) is the most severe variant of autosomal recessive congenital ichthyosis (ARCI). It is characterized at birth by the presence of large, thick, plate-like scales over the whole body associated with severe ectropion, eclabium, and flattened ears, that later develops into a severe scaling erythroderma.


presynaptic congenital myasthenic syndrome


congenital myasthenic syndrome 10

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the DOK7 gene.


congenital myasthenic syndrome 2A

A congenital myasthenic syndrome characterized by autosomal dominant inheritance of postsynaptic neuromuscular junction defects, early-onset progressive muscle weakness, and prolonged opening and activity of the acetylcholine receptor channel that has material basis in heterozygous mutation in the CHRNB1 gene on chromosome 17p13.


blepharocheilodontic syndrome 2

Any blepharo-cheilo-odontic syndrome in which the cause of the disease is a mutation in the CTNND1 gene.


inverse Marcus-Gunn phenomenon

Inverse Marcus-Gunn phenomenon is a rare congenital synkinesis where jaw opening by the pterygoid muscle (during eating or yawning) causes eyelid drooping from inhibition of the oculomotor nerve to the levator palpebrae superioris. Familial occurrence has been reported.


congenital myasthenic syndrome with tubular aggregates

A congenital myasthenic syndrome with a finding of tubular aggregates in myofibers.


ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3

Any EEC syndrome in which the cause of the disease is a mutation in the TP63 gene.


blepharophimosis-epicanthus inversus-ptosis due to copy number variations

Blepharophimosis - epicanthus inversus - ptosis (BPES) due to polyA expansion is a form of BPES, characterized by the classical eyelid malformation (blepharophimosis, ptosis, epicanthus inversus, and telecanthus) which may be associated with a mild ovarian involvement.


ptosis-upper ocular movement limitation-absence of lacrimal punctum syndrome

Ptosis - upper ocular movement limitation - absence of lacrimal punctum is a recently described association of absence of the lower lid lacrimal punctum, bilateral ptosis, elevation deficiency of both eyes and mild facial dysmorphism.


camptodactyly, myopia, and fibrosis of the medial rectus muscle of eye

A rare multiple congenital anomalies syndrome characterized by the association of camptodactyly, multiple eye defects (fibrosis of the medial rectus muscle, severe myopia, ptosis and exophthalmos), scoliosis, flexion contractures and facial anomalies (arched eyebrows, facial asymmetry with an abnormal skull shape, a prominent nose, small mouth, low-set and dysplastic ears, and a low nuchal hairline).


blepharophimosis-epicanthus inversus-ptosis due to 3q23 rearrangement syndrome

Blepharophimosis - epicanthus inversus - ptosis (BPES) due to 3q23 microdeletion is a form of BPES, which in addition to the classical eyelids features of BPES, present genitourinary anomalies, spastic diplegia and speech delay.


congenital myasthenic syndrome 3A

A congenital myasthenic syndrome characterized by autosomal dominant inheritance of postsynaptic neuromuscular junction defects resulting in prolonged synaptic currents and early-onset progressive muscle weakness that has material basis in heterozygous mutation in the CHRND gene on chromosome 2q37.


congenital myasthenic syndrome 20

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the SLC5A7 gene.


blepharocheilodontic syndrome

An ectodermal dysplasia syndrome characterized by the association of abnormalities of the eyelids, lips, and teeth.


myasthenic syndrome, congenital, 24, presynaptic


postaxial acrofacial dysostosis

Postaxial acrofacial dysostosis (POADS) is a type of acrofacial dysostosis characterised by mandibular and malar hypoplasia, small and cup-shaped ears, lower lid ectropion, and symmetrical postaxial limb deficiencies with absence of the fifth digital ray and ulnar hypoplasia.


congenital myasthenic syndrome 16

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the SCN4A gene.


Barber-Say syndrome

Barber Say syndrome (BSS) is a rare ectodermal dysplasia with neonatal onset characterized by congenital generalized hypertrichosis, atrophic skin, ectropion and microstomia.


oculopharyngodistal myopathy

Oculopharyngodistal myopathy (OPDM) is a rare, adult-onset hereditary muscle disease. People with OPDM present with progressive eye and throat (pharyngeal) problems and involvement of the muscles of the lower legs and arms. Symptoms may include eyelid drooping (ptosis), swallowing difficulty, hoarse and nasal voice, leg and arm weakness, as well as muscle wasting in the face and in the legs and arms. Many people have respiratory problems due to respiratory muscle weakness. In rare cases, there is also hearing loss, as well as severe weakness in muscles of the forearms and thighs. As the disease progresses, other muscles may be affected. A blood exam may show an increased creatine kinase level and an abnormal EMG. Inheritance may be autosomal dominant or autosomal recessive. The specific cause is still unknown.


fibrosis of extraocular muscles, congenital, with synergistic divergence


metopic ridging-ptosis-facial dysmorphism syndrome


congenital myasthenic syndrome 14

Any congenital myasthenic syndromes with glycosylation defect in which the cause of the disease is a mutation in the ALG2 gene.


congenital myasthenic syndrome 9

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the MUSK gene.


isolated congenital ectropion

A congenital ectropion that is not part of a larger syndrome.


fibrosis of extraocular muscles, congenital, 3b


lamellar ichthyosis

A keratinization disorder characterized by the presence of large scales all over the body without significant erythroderma.


congenital myasthenic syndrome 18

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the SNAP25 gene.


tarsal kink syndrome

Tarsal kink syndrome is a rare congenital malformation of the tarsus that causes entropion characterized by blepharospasm and absence of an upper eyelid fold that may lead to corneal ulceration caused by the folded edge of the upper tarsus or the inturned eyelashes if not corrected by surgery.


myasthenic syndrome, congenital, 7B, presynaptic, autosomal recessive


myasthenia, congenital, refractory to acetylcholinesterase inhibitors


keratosis follicularis spinulosa decalvans

Keratosis follicularis spinulosa decalvans is a rare genodermatosis occurring during infancy or childhood, predominantly affecting males, and characterized by diffuse follicular hyperkeratosis associated with progressive cicatricial alopecia of the scalp, eyebrows and eyelashes. Additional findings can include photophobia, corneal dystrophy, facial erythema, and/or palmoplantar keratoderma.


Char syndrome

Char syndrome is characterized by the triad of patent ductus arteriosus (PDA), facial dysmorphism and hand anomalies.


blepharocheilodontic syndrome 1

Any blepharo-cheilo-odontic syndrome in which the cause of the disease is a mutation in the CDH1 gene.


congenital fibrosis of extraocular muscles type 1

Any congenital fibrosis of extraocular muscles in which the cause of the disease is a mutation in the KIF21A gene.


congenital myasthenic syndrome 2C

A congenital myasthenic syndrome characterized by autosomal recessive inheritance of postsynaptic neuromuscular junction defects, early-onset muscle weakness, and low amplitude of the miniature endplate potential and current that has material basis in ompound heterozygous mutation in the CHRNB1 gene on chromosome 17p13.


blepharophimosis, ptosis, and epicanthus inversus syndrome

Blepharophimosis, Ptosis, and Epicanthus Inversus syndrome (BPES) is an ophthalmic disorder characterized by blepharophimosis, ptosis, epicanthus inversus, and telecanthus, that can appear associated with (type I) or without premature ovarian failure (POF) (type II).


Baraitser-Winter syndrome (BWS) is a malformation syndrome, characterized by facial dysmorphism (hypertelorism with ptosis, broad bulbous nose, ridged metopic suture, arched eyebrows, progressive coarsening of the face), ocular coloboma, pachygyria and/or band heterotopias with antero-posterior gradient, progressive joint stiffening, and intellectual deficit of variable severity, often with severe epilepsy. Pachygyria - epilepsy - intellectual disability - dysmorphism (Fryns-Aftimos syndrome (FA)) corresponds to the appearance of BWS in elderly patients.


A syndrome characterized by the association of gastrointestinal dysmotility, peripheral neuropathy, chronic progressive external ophthalmoplegia and leukoencephalopathy.


Baraitser-winter syndrome 2

Any Baraitser-Winter cerebrofrontofacial syndrome in which the cause of the disease is a mutation in the ACTG1 gene.


myasthenic syndrome, congenital, 25, presynaptic


congenital myasthenic syndrome 4A

A congenital myasthenic syndrome characterized by postsynaptic neuromuscular junction defects, early-onset progressive muscle weakness, and prolonged opening and activity of the acetylcholine receptor channel that has material basis in heterozygous or rarely biallelic mutation in the CHRNE gene on chromosome 17p13.


congenital myasthenic syndrome 4B

A congenital myasthenic syndrome characterized by autosomal recessive inheritance of postsynaptic neuromuscular junction defects, early-onset progressive muscle weakness, and kinetic abnormalities of the AChR channel that has material basis in homozygous or compound heterozygous mutation in the CHRNE gene on chromosome 17p13.


fibrosis of extraocular muscles, congenital, 2

Any congenital fibrosis of extraocular muscles in which the cause of the disease is a mutation in the PHOX2A gene.


fibrosis of extraocular muscles, congenital, 3A, with or without extraocular involvement

Any congenital fibrosis of extraocular muscles in which the cause of the disease is a mutation in the TUBB3 gene.


congenital myasthenic syndrome 8

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the AGRN gene.


ptosis-vocal cord paralysis syndrome

Ptosis-vocal cord paralysis syndrome is a rare, hereditary disorder with ptosis characterized by the combination of congenital bilateral recurrent laryngeal nerve paralysis and congenital bilateral ptosis. There have been no further descriptions in the literature since 1983.


blepharophimosis-ptosis-epicanthus inversus syndrome type 2


congenital myasthenic syndromes with glycosylation defect


congenital myasthenic syndrome 13

Any congenital myasthenic syndromes with glycosylation defect in which the cause of the disease is a mutation in the DPAGT1 gene.


atrioventricular defect-blepharophimosis-radial and anal defect syndrome

Atrioventricular defect-blepharophimosis-radial and anal defect syndrome is a rare, genetic multiple congenital anomaly syndrome characterized by atrioventricular septal defects and blepharophimosis, in addition to radial (e.g. aplastic radius, shortened ulna, fifth finger clinodactyly, absent first metacarpal and thumb) and anal (e.g. imperforate or anteriorly place anus, rectovaginal fistula) defects.


ichthyosis, lamellar, autosomal dominant


myotonic dystrophy type 2

Myotonic dystrophy type 2 (MD2), also known as proximal myotonic myopathy, is a very rare genetic multi-system disorder of late childhood or adult-onset characterized by mild myotonia, muscle weakness, and rarely cardiac conduction disorders.


Martinez Monasterio Pinheiro syndrome

A form of blepharo-cheilo-dontic syndrome with with cleft lip and palate, complete absence of deciduous teeth, hypodontia of permanent teeth, hair alterations, hypertelorism, midface hypoplasia, abnormal EEG, syndactyly, and other findings. This is an n-of-1 use case where only one patient or family has been described with this disorder.


congenital myasthenic syndrome 21

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the SLC18A3 gene.


congenital myasthenic syndrome 19

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the COL13A1 gene.


fibrosis of extraocular muscles, congenital, 3c


autosomal recessive congenital ichthyosis 8

Any autosomal recessive congenital ichthyosis in which the cause of the disease is a mutation in the LIPN gene.


congenital myasthenic syndrome 3C

A congenital myasthenic syndrome characterized by autosomal recessive inheritance of postsynaptic neuromuscular junction defects, low amplitude of the miniature endplate potential and current, and early-onset muscle weakness that has material basis in compound heterozygous mutation in the CHRND gene on chromosome 2q37.


Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome is characterised by the association of blepharophimosis and ptosis, V-esotropia, and weakness of extraocular and frontal muscles with syndactyly of the toes, short stature, prognathism, and hypertrophy and fusion of the eyebrows. It has been described in six members of three related families. Transmission is autosomal recessive.


Acrootoocular syndrome

Acro-oto-ocular syndrome is a very rare disorder associating pseudopapilledema (optic disc swelling not secondary to increased intracranial pressure), mixed hearing loss, facial dysmorphism and limb extremity anomalies.


autosomal recessive congenital ichthyosis 6

Any autosomal recessive congenital ichthyosis in which the cause of the disease is a mutation in the NIPAL4 gene.


blepharophimosis-ptosis-epicanthus inversus syndrome type 1


oculopharyngeal muscular dystrophy

Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset progressive myopathy characterized by progressive eyelid ptosis, dysphagia, dysarthria and proximal limb weakness.


dopamine beta-hydroxylase deficiency

Dopamine beta-hydroxylase deficiency is an extremely rare genetic metabolic disorder characterized by autonomic dysregulation leading mainly to orthostatic hypotension.


autosomal recessive congenital ichthyosis 5

An autosomal recessive congenital ichthyosis characterized by fine white or greyish-white scales, hyperkeratosis, moderate acanthosis, and moderate parakeratosis that has material basis in homozygous mutation in the CYP4F22 gene on chromosome 19p13.


Baraitser-Winter syndrome 1

Any Baraitser-Winter cerebrofrontofacial syndrome in which the cause of the disease is a mutation in the ACTB gene.


postsynaptic congenital myasthenic syndrome


fibrosis of extraocular muscles, congenital, 5

Any congenital fibrosis of extraocular muscles in which the cause of the disease is a mutation in the COL25A1 gene.


isolated congenital entropion

A rare eyelid malposition disorder characterized by congenital abnormal inversion of the eyelid towards the globe, potentially causing mechanical irritation of the ocular surface by the eyelashes, which may lead to corneal abrasion and scarring with visual impairment. Typical initial symptoms are foreign body sensation, redness, tearing, and ocular discharge.


congenital myasthenic syndrome 3B

A congenital myasthenic syndrome characterized by autosomal recessive inheritance of postsynaptic neuromuscular junction defects resulting in rapid decay in endplate current and a failure to reach the threshold for depolarization and early onset progressive muscular weakness that has material basis in homozygous or compound heterozygous mutation in the CHRND gene on chromosome 2q37.


Wiedemann-Rautenstrauch syndrome

Wiedemann-Rautenstrauch syndrome is a very rare disorder with features of premature aging recognizable at birth, decreased subcutaneous fat, hypotrichosis, relative macrocephaly and dysmorphism.


keratosis follicularis spinulosa decalvans, autosomal dominant


blepharophimosis-epicanthus inversus-ptosis due to a point mutation syndrome

Blepharophimosis-epicanthus inversus-ptosis (BPES) due to a point mutation is a form of BPES, characterized by the classical eyelid malformation (blepharophimosis, ptosis, epicanthus inversus, and telecanthus) which may be accompanied by growth retardation and primary ovary failure.


congenital myasthenic syndrome 1A

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the CHRNA1 gene.


autosomal recessive congenital ichthyosis 4A

Any autosomal recessive congenital ichthyosis in which the cause of the disease is a mutation in the ABCA12 gene.


congenital myasthenic syndrome 7

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the SYT2 gene.


keratosis follicularis spinulosa decalvans, X-linked


maternally-inherited progressive external ophthalmoplegia


congenital myasthenic syndrome 15

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the ALG14 gene.


Ptosis-strabismus-ectopic pupils syndrome is characterised by the association of ptosis, strabismus and ectopic pupils. It has been described in one family (in a mother and three of her children). Transmission is autosomal dominant.


ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 1

An EEC syndrome characterized by autosomal dominant inheritance that has material basis in variation in the chromosome region 7q11.2-q21.3.


congenital myasthenic syndrome 17

Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the LRP4 gene.


osteogenesis imperfecta type 12

Any osteogenesis imperfecta in which the cause of the disease is a mutation in the SP7 gene.


combined immunodeficiency due to DOCK8 deficiency

Combined immunodeficiency due to dedicator of cytokinesis 8 protein (DOCK8) deficiency is a form of T and B cell immunodeficiency characterized by recurrent cutaneous viral infections, susceptibility to cancer and elevated serum levels of immunoglobulin E (IgE).


caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule.


acrodysostosis 1 with or without hormone resistance

An autosomal dominant skeletal dysplasia caused by mutation(s) in the PRKAR1A gene, encoding cAMP-dependent protein kinase type I-alpha regulatory subunit. It is characterized by short stature, brachydactyly, and characteristic facial features. Resistance to multiple hormones is a common finding.


acrodysostosis

Acrodysostosis (ACRDYS) is a rare primary bone dysplasia characterized by severe brachydactyly, peripheral dysostosis with facial dysostosis, nasal hypoplasia, and developmental delay.


acrodysostosis 2 with or without hormone resistance

Any acrodysostosis in which the cause of the disease is a mutation in the PDE4D gene.


positive regulation of branchiomeric skeletal muscle development

Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure.


positive regulation of extraocular skeletal muscle development

Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle.


positive regulation of somitomeric trunk muscle development

Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle.


cystic artery

An artery that supplies oxygenated blood to the cystic duct.


ethmoidal sinus neoplasm

A benign or malignant neoplasm that affects the ethmoid sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


benign neoplasm of sphenoidal sinus

A non-metastasizing neoplasm that arises from the sphenoid sinus.


sphenoidal sinus neoplasm

A benign or malignant neoplasm that affects the sphenoid sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


maxillary sinus neoplasm

A benign or malignant neoplasm that affects the maxillary sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


benign neoplasm of ethmoidal sinus

A benign neoplasm that involves the ethmoid sinus.


benign neoplasm of maxillary sinus

A benign neoplasm that involves the maxillary sinus.


paranasal sinus cancer

A primary or metastatic malignant neoplasm involving the paranasal sinuses.


ethmoid sinus ectopic meningioma

An extremely rare meningioma that arises as a primary ectopic tumor in the ethmoid sinus.


frontal sinus neoplasm

A benign or malignant neoplasm that affects the frontal sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


benign neoplasm of frontal sinus

A benign neoplasm that involves the frontal sinus.


paranasal sinus lymphoma

A lymphoma that arises from the paranasal sinus. Representative examples include diffuse large B-cell lymphoma and extranodal NK/T-cell lymphoma, nasal type.


Carcinoid tumor of the duodenum

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the duodenum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Acute Megakaryoblastic Leukemia with NUP98-KDM5A

A non-Down syndrome acute megakaryoblastic leukemia that occurs in childhood. It is associated with t(11;12)(p15;p13) which results in the presence of NUP98-KDM5A chimeric oncogene.


RNA polymerase II C-terminal domain phosphoserine binding

Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II.


adult germ cell tumor

A germ cell tumor that occurs during adulthood.


adult teratoma

A teratoma that occurs in an adult.


adult cystic teratoma

A cystic teratoma that occurs in an adult.


D-ornithine metabolic process

The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid.


amyotrophic lateral sclerosis type 11

Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the FIG4 gene.


RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity

Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) = RNA polymerase II large subunit trans-proline (omega=0).


RNA polymerase II CTD heptapeptide repeat P3 isomerase activity

Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 3) = RNA polymerase II large subunit trans-proline (omega=0) (position 3).


RNA polymerase II CTD heptapeptide repeat P6 isomerase activity

Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 6) = RNA polymerase II large subunit trans-proline (omega=0) (position 6).


NADH dehydrogenase complex (plastoquinone) assembly

The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I.


plus-end directed microtubule sliding

The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules.


FAD-dependent H3K4me/H3K4me3 demethylase activity

Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.


histone H3K4me/H3K4me2/H3K4me3 demethylase activity

Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


positive regulation of NAD+ ADP-ribosyltransferase activity

Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.


negative regulation of NAD+ ADP-ribosyltransferase activity

Any process that stops, prevents or reduces the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.


ribosylnicotinate kinase activity

Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide.


paraflagellar rod assembly

The aggregation, arrangement and bonding together of a set of components to form a paraflagellar rod, a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme.


sperm flagellum assembly

The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium).


non-motile cilium assembly

The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium.


cytosolic ciliogenesis

The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm.


facioscapulohumeral muscular dystrophy 1

Any facioscapulohumeral muscular dystrophy in which the cause of the disease is a mutation in the FRG1 gene.


cellular response to glyceraldehyde

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus.


response to D-galactose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus.


response to mannose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus.


response to glyceraldehyde

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus.


cellular response to D-galactose

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus.


cellular response to mannose

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus.


response to rhamnose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus.


cellular response to rhamnose stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus.


Gollop-Wolfgang complex

Gollop-Wolfgang complex is a very rare malformation characterized by ectrodactyly of the hand and ipsilateral bifurcation of the femur.


Recurrent Salivary Duct Carcinoma

The reemergence of salivary duct carcinoma after a period of remission.


left renal pelvis

A renal pelvis that is part of a left ureter.


right renal pelvis

A renal pelvis that is part of a right ureter.


metanephric renal pelvis

A renal pelvis that is part of a metanephros.


Stage I Rectal Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


cornea plana 2

Any cornea plana in which the cause of the disease is a mutation in the KERA gene.


CIC-DUX4 Sarcoma

An undifferentiated, high grade small round cell sarcoma affecting predominantly young adults. It is characterized by a recurrent translocation involving the CIC gene on chromosome 19 and DUX4 gene on chromosome 4. The translocation results in CIC-DUX4, t(4;19)(q35;q13) fusions.


Senile dementia

Loss of intellectual abilities in an elderly person, interfering with this person's activities.


Cacosmia

A hallucination of an unpleasant odor.


adrenomedullin binding

Binding to adrenomedullin (AM).


ubiquitin activating enzyme binding

Binding to a ubiquitin activating enzyme, any of the E1 proteins.


myosin III binding

Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain.


prostaglandin D2 receptor binding

Binding to a prostaglandin D2 receptor.


type 2 neuromedin U receptor binding

Binding to a type 2 neuromedin U receptor.


leukotriene receptor binding

Binding to a leukotriene receptor.


cysteinyl leukotriene receptor binding

Binding to a cysteinyl leukotriene receptor.


actin lateral binding

Binding to an actin filament along its length.


B1 bradykinin receptor binding

Binding to a B1 bradykinin receptor.


intramolecular proline-rich ligand binding

Binding to a proline-rich region within the same polypeptide.


sumo-dependent protein binding

Binding to a protein upon sumoylation of the target protein.


alpha-1D adrenergic receptor binding

Binding to an alpha-1D adrenergic receptor.


receptor tyrosine kinase-like orphan receptor binding

Binding to a receptor tyrosine kinase-like orphan receptor (Ror).


adipokinetic hormone binding

Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


glutamate-cysteine ligase catalytic subunit binding

Binding to the catalytic subunit of glutamate-cysteine ligase.


type 4 proteinase activated receptor binding

Binding to a type 4 proteinase activated receptor.


HDEL sequence binding

Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.


type 6 serotonin receptor binding

Binding to a type 6 serotonin receptor.


type 2B serotonin receptor binding

Binding to a type 2B serotonin receptor.


interleukin-9 binding

Binding to interleukin-9.


type 2 metabotropic GABA receptor binding

Binding to a type 2 metabotropic GABA receptor.


protein phosphatase 5 binding

Binding to protein phosphatase 5.


type 1 cannabinoid receptor binding

Binding to a type 1 cannabinoid receptor.


GAF domain binding

Binding to a GAF protein domain.


enzyme binding

Binding to an enzyme, a protein with catalytic activity.


sevenless binding

Binding to a sevenless (sev) protein, a receptor tyrosine kinase.


type-I cohesin domain binding

Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain.


complement component C5a binding

Binding to a C5a product of the complement cascade.


type 2 somatostatin receptor binding

Binding to a type 2 somatostatin receptor.


substance P receptor binding

Binding to a substance P receptor.


type A cholecystokinin receptor binding

Binding to a type A cholecystokinin receptor.


amylin binding

Binding to amylin.


receptor-receptor interaction

The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.


RNA polymerase II-specific DNA-binding transcription factor binding

Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.


complement component iC3b binding

Binding to a iC3b product of the complement cascade.


type 2 neuropeptide Y receptor binding

Binding to a type 2 neuropeptide Y receptor.


D4 dopamine receptor binding

Binding to a D4 dopamine receptor.


alpha-2B adrenergic receptor binding

Binding to an alpha-2B adrenergic receptor.


TFIIE-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


preprotein binding

Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing.


interleukin-21 binding

Binding to interleukin-21.


hemoglobin beta binding

Binding to a hemoglobin beta chain.


SOCS family protein binding

Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions.


MHC class Ib protein binding, via antigen binding groove

Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove.


GTP cyclohydrolase binding

Binding to a GTP cyclohydrolase.


P2Y10 nucleotide receptor binding

Binding to a P2Y10 nucleotide receptor.


P2Y8 nucleotide receptor binding

Binding to a P2Y8 nucleotide receptor.


thromboxane A2 receptor binding

Binding to a thromboxane A2 receptor.


type-II cohesin domain binding

Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain.


type 1 somatostatin receptor binding

Binding to a type 1 somatostatin receptor.


G protein-coupled histamine receptor binding

Binding to a G protein-coupled (metabotropic) histamine receptor.


myosin I tail binding

Binding to the tail region of a myosin I heavy chain.


myosin XI tail binding

Binding to the tail region of a myosin XI heavy chain.


TIR domain binding

Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components.


kringle domain binding

Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors.


interleukin-26 binding

Binding to interleukin-26.


beta-endorphin receptor binding

Binding to a beta-endorphin receptor.


interleukin-11 binding

Binding to interleukin-11.


type 1B melatonin receptor binding

Binding to a type 1B melatonin receptor.


type B gastrin/cholecystokinin receptor binding

Binding to a type B gastrin/cholecystokinin receptor.


hexon binding

Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus.


P2Y6 nucleotide receptor binding

Binding to a P2Y6 nucleotide receptor.


type 1 cysteinyl leukotriene receptor binding

Binding to a type 1 cysteinyl leukotriene receptor.


G protein-coupled acetylcholine receptor binding

Binding to a G protein-coupled acetylcholine receptor.


denatured protein binding

Binding to a denatured protein.


urotensin receptor binding

Binding to a urotensin receptor.


TFIIA-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.


chemokine (C-C motif) ligand 21 binding

Binding to chemokine (C-C motif) ligand 21.


neuromedin K receptor binding

Binding to a neuromedin K receptor.


glycosylated region protein binding

Binding to a glycosylated region of a protein.


ganglioside binding

Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues.


V2 vasopressin receptor binding

Binding to a V2 vasopressin receptor.


H3 histamine receptor binding

Binding to a H3 histamine receptor.


type 4 metabotropic glutamate receptor binding

Binding to a type 4 metabotropic glutamate receptor.


MHC class I protein binding, via antigen binding groove

Binding to a major histocompatibility complex class I molecules via the antigen binding groove.


myosin I heavy chain binding

Binding to a heavy chain of a myosin I complex.


zf-TRAF domain binding

Binding to a TRAF-type zinc finger domain of a protein.


G-protein gamma-subunit binding

Binding to a G-protein gamma subunit.


cytoskeletal regulatory protein binding

Binding to a protein involved in modulating the reorganization of the cytoskeleton.


Edg-6 sphingosine 1-phosphate receptor binding

Binding to an Edg-6 sphingosine 1-phosphate receptor.


interleukin-22 binding

Binding to interleukin-22.


plastid single-subunit type RNA polymerase binding

Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


TFIIIB-class transcription factor complex binding

Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.


C2 domain binding

Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes.


cholecystokinin receptor binding

Binding to a cholecystokinin receptor.


talin binding

Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types.


type 2 metabotropic glutamate receptor binding

Binding to a type 2 metabotropic glutamate receptor.


prolactin-releasing peptide receptor binding

Binding to a prolactin-releasing peptide receptor.


glycosylation-dependent protein binding

Binding to a protein upon glycosylation of the target protein.


BH1 domain binding

Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists.


EP3 subtype prostaglandin E2 receptor binding

Binding to an EP3 subtype prostaglandin E2 receptor.


type III interferon binding

Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far.


protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.


peptidyl-proline 4-dioxygenase binding

Binding to a peptidyl-proline 4-dioxygenase.


Edg-4 lysophosphatidic acid receptor binding

Binding to an Edg-4 lysophosphatidic acid receptor.


mitochondrial single-subunit type RNA polymerase binding

Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


chemokine (C-C motif) ligand 7 binding

Binding to chemokine (C-C motif) ligand 7.


RNA polymerase II complex recruiting activity

Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.


CH domain binding

Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins.


cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.


vacuolar sorting signal binding

Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole.


interleukin-19 binding

Binding to interleukin-19.


C-X3-C chemokine binding

Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.


collectin binding

Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus.


secretin receptor binding

Binding to a secretin receptor.


RBL family protein binding

Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose.


calcitonin binding

Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid.


neuromedin U receptor binding

Binding to one or more specific sites on a neuromedin U receptor.


K6-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein.


eukaryotic initiation factor 4G binding

Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.


interleukin-18 binding

Binding to interleukin-18.


P2Y11 nucleotide receptor binding

Binding to a P2Y11 nucleotide receptor.


MDA-5 binding

Binding to MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA.


Binding to a protein upon phosphorylation of the target protein.


type 1 metabotropic GABA receptor binding

Binding to a type 1 metabotropic GABA receptor.


type 2C serotonin receptor binding

Binding to a type 2C serotonin receptor.


melanin-concentrating hormone receptor binding

Binding to a melanin-concentrating hormone receptor.


Edg-1 sphingosine 1-phosphate receptor binding

Binding to an Edg-1 sphingosine 1-phosphate receptor.


K11-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein.


type 5B serotonin receptor binding

Binding to a type 5B serotonin receptor.


neuromedin U binding

Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses.


gonadotropin-releasing hormone receptor binding

Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.


type 1 neuromedin U receptor binding

Binding to a type 1 neuromedin U receptor.


platelet activating factor receptor binding

Binding to a platelet activating factor receptor.


parathyroid hormone receptor binding

Binding to a parathyroid hormone receptor.


nuclear mineralocorticoid receptor binding

Binding to a nuclear mineralocorticoid receptor.


identical protein binding

Binding to an identical protein or proteins.


macrophage migration inhibitory factor binding

Binding to the cytokine, macrophage migration inhibitory factor.


granulocyte macrophage colony-stimulating factor complex binding

Binding to a granulocyte macrophage colony-stimulating factor complex.


corticotropin-releasing hormone binding

Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.


pentraxin binding

Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array.


A2B adenosine receptor binding

Binding to an A2B adenosine receptor.


cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication

Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells.


bacterial-type RNA polymerase core enzyme binding

Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit.


high molecular weight B cell growth factor receptor binding

Binding to a high molecular weight B cell growth factor receptor.


TFIIH-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


STAT family protein binding

Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.


Hsp27 protein binding

Binding to Hsp27 proteins, a lightweight heat shock protein.


BIR domain binding

Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain.


RNA polymerase II C-terminal domain binding

Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function.


interleukin-12 alpha subunit binding

Binding to the alpha subunit of interleukin-12.


prostacyclin receptor binding

Binding to a prostacyclin receptor.


chloroplast targeting sequence binding

Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.


interleukin-13 binding

Binding to interleukin-13.


cell adhesion receptor activity

The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins.


EP2 subtype prostaglandin E2 receptor binding

Binding to an EP2 subtype prostaglandin E2 receptor.


somatostatin binding

Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin.


fMet-Leu-Phe receptor binding

Binding to a fMet-Leu-Phe receptor.


MHC class II protein binding, via lateral surface

Binding to the lateral surface of major histocompatibility complex class II molecules.


scavenger receptor binding

Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.


type 6 metabotropic glutamate receptor binding

Binding to a type 6 metabotropic glutamate receptor.


type 7 metabotropic glutamate receptor binding

Binding to a type 7 metabotropic glutamate receptor.


DH domain binding

Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.


type 1 orexin receptor binding

Binding to a type 1 orexin receptor.


complement component C3d binding

Binding to a C3d product of the complement cascade.


translation elongation factor binding

Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation.


single-subunit type RNA polymerase binding

Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


interleukin-27 binding

Binding to interleukin-27.


TFIIB-class transcription factor binding

Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


type 1B serotonin receptor binding

Binding to a type 1B serotonin receptor.


Edg-7 lysophosphatidic acid receptor binding

Binding to an Edg-7 lysophosphatidic acid receptor.


arrestin family protein binding

Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.


dynein light chain binding

Binding to a light chain of the dynein complex.


type 1 neurotensin receptor binding

Binding to a type 1 neurotensin receptor.


type-III cohesin domain binding

Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain.


peroxisome membrane class-2 targeting sequence binding

Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner.


penicillin binding

Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.


TFIIIA-class transcription factor binding

Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters.


DNA binding domain binding

Binding to a protein's DNA binding domain (DBD).


ADP-D-ribose modification-dependent protein binding

Binding to a protein upon ADP-ribosylation of the target protein.


ciliary neurotrophic factor binding

Binding to the cytokine ciliary neurotrophic factor.


orexin receptor binding

Binding to an orexin receptor.


zymogen binding

Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.


EP4 subtype prostaglandin E2 receptor binding

Binding to an EP4 subtype prostaglandin E2 receptor.


FYXD domain binding

Binding to a FXYD domain.


calcium-dependent outer dynein arm binding

Binding to an outer dynein arm in the presence of calcium.


interleukin-33 binding

Binding to interleukin-33.


triacyl lipopeptide binding

Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups.


peroxisome matrix targeting signal-2 binding

Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F).


glial cell-derived neurotrophic factor receptor binding

A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors.


GBD domain binding

Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.


proctolin receptor binding

Binding to a proctolin receptor.


hepatocyte growth factor binding

Binding to a hepatocyte growth factor.


H9 melatonin receptor binding

Binding to a H9 melatonin receptor.


glucagon receptor binding

Binding to a glucagon receptor.


type 1 member 3 taste receptor binding

Binding to a type 1 member 3 taste receptor.


myosin VI light chain binding

Binding to a light chain of a myosin VI complex.


endocytic targeting sequence binding

Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits.


MATH domain binding

Binding to a meprin and TRAF homology (MATH) domain.


intercellular adhesion molecule-3 receptor binding

Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1.


cell adhesive protein binding involved in AV node cell-bundle of His cell communication

Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells.


H2 histamine receptor binding

Binding to a H2 histamine receptor.


corazonin receptor binding

Binding to a corazonin receptor.


myosin VI heavy chain binding

Binding to a heavy chain of a myosin VI complex.


MH2 domain binding

Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.


RIP homotypic interaction motif binding

Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases.


interleukin-10 binding

Binding to interleukin-10.


ErbB-4 class receptor binding

Binding to the protein-tyrosine kinase receptor ErbB-4/HER4.


V1B vasopressin receptor binding

Binding to a V1B vasopressin receptor.


MADS box domain binding

Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs.


type 1 member 1 taste receptor binding

Binding to a type 1 member 1 taste receptor.


low molecular weight kininogen binding

Binding to a kininogen of low molecular mass.


type 7 serotonin receptor binding

Binding to a type 7 serotonin receptor.


neuropeptide F receptor binding

Binding to a neuropeptide F receptor.


acetylation-dependent protein binding

Binding to a protein upon acetylation of the target protein.


CRD domain binding

Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins.


nuclear cortisol receptor binding

Binding to a nuclear cortisol receptor.


DNA-binding transcription factor binding

Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.


chemokine (C-C motif) ligand 12 binding

Binding to chemokine (C-C motif) ligand 12.


type 4 neuropeptide Y receptor binding

Binding to a type 4 neuropeptide Y receptor.


linear polyubiquitin binding

Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next.


prostaglandin F2-alpha receptor binding

Binding to a prostaglandin F2-alpha receptor.


farnesylated protein binding

Binding to a farnesylated protein.


pituitary adenylate cyclase-activating polypeptide receptor binding

Binding to a pituitary adenylate cyclase-activating polypeptide receptor.


gastric inhibitory polypeptide receptor binding

Binding to a gastric inhibitory polypeptide receptor.


myosin II head/neck binding

Binding to the head/neck region of a myosin II heavy chain.


type-II dockerin domain binding

Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain.


interleukin-17 binding

Binding to a member of the interleukin-17 family of cytokines.


laminin binding involved in cell-matrix adhesion

Any laminin protein binding that occurs as part of cell-matrix adhesion.


orexigenic neuropeptide QRFP receptor binding

Binding to an orexigenic neuropeptide QRFP receptor.


ciliary targeting signal binding

Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane.


gonadotropin-releasing hormone binding

Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


A3 adenosine receptor binding

Binding to an A3 adenosine receptor.


poly-ADP-D-ribose modification-dependent protein binding

Binding to a protein upon poly-ADP-ribosylation of the target protein.


subtype 3 bombesin receptor binding

Binding to a subtype 3 bombesin receptor.


thioglucosidase binding

Binding to a thioglucosidase enzyme.


Krueppel-associated box domain binding

Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.


Rel homology domain binding

Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT.


urea binding

Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2.


DDEL sequence binding

Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.


oxytocin receptor binding

Binding to an oxytocin receptor.


kisspeptin receptor binding

Binding to a kisspeptin receptor.


type 1D serotonin receptor binding

Binding to a type 1D serotonin receptor.


H3K27me3 modified histone binding

Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation.


high mobility group box 1 binding

Binding to high mobility group box 1 (HMBGB1).


adrenomedullin receptor binding

Binding to an adrenomedullin receptor.


type 1 melanin-concentrating hormone receptor binding

Binding to a type 1 melanin-concentrating hormone receptor.


LEM domain binding

Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF).


syntaxin-3 binding

Binding to a syntaxin-3 SNAP receptor.


thyrotropin-releasing hormone receptor binding

Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary.


CAP-Gly domain binding

Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets.


MHC class I protein binding, via lateral surface

Binding to a major histocompatibility complex class I molecules via the lateral surface.


EGF repeat binding

Binding to Epidermal Growth Factor (EGF) repeats.


type 2 vasoactive intestinal polypeptide receptor binding

Binding to a type 2 vasoactive intestinal polypeptide receptor.


type 5 metabotropic glutamate receptor binding

Binding to a type 5 metabotropic glutamate receptor.


interleukin-25 binding

Binding to interleukin-25.


cannabinoid receptor binding

Binding to a cannabinoid receptor.


cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication

Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells.


P2Y2 nucleotide receptor binding

Binding to a P2Y2 nucleotide receptor.


SMC family protein binding

Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization.


AF-1 domain binding

Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor.


type 5 somatostatin receptor binding

Binding to a type 5 somatostatin receptor.


CD70 receptor binding

Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells.


imaginal disc growth factor receptor binding

Binding to an imaginal disc growth factor receptor.


neuregulin binding

Binding to a neuregulin, a member of the EGF family of growth factors.


ubiquitin modification-dependent histone binding

Binding to a histone protein in which a residue has been modified by ubiquitination.


Toll binding

Binding to a Toll protein, a transmembrane receptor.


chemokine (C-C motif) ligand 19 binding

Binding to chemokine (C-C motif) ligand 19.


POU domain binding

Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors.


C5a anaphylatoxin chemotactic receptor binding

Binding to a C5a anaphylatoxin chemotactic receptor.


Edg-3 sphingosine 1-phosphate receptor binding

Binding to an Edg-3 sphingosine 1-phosphate receptor.


TFIIF-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


type 8 metabotropic glutamate receptor binding

Binding to a type 8 metabotropic glutamate receptor.


eukaryotic initiation factor eIF2 binding

Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation.


type 3 proteinase activated receptor binding

Binding to a type 3 proteinase activated receptor.


H4 histamine receptor binding

Binding to a H4 histamine receptor.


type 5 neuropeptide Y receptor binding

Binding to a type 5 neuropeptide Y receptor.


growth hormone-releasing hormone receptor binding

Binding to a growth hormone-releasing hormone receptor.


RIG-I binding

Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.


C5L2 anaphylatoxin chemotactic receptor binding

Binding to a C5L2 anaphylatoxin chemotactic receptor.


phosphorylated histone binding

Binding to a histone in which a residue has been modified by phosphorylation.


microtubule lateral binding

Binding to the side of a microtubule.


phytochrome binding

Binding to a phytochrome.


myosin VI head/neck binding

Binding to the head/neck region of a myosin VI heavy chain.


poly-glutamine tract binding

Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein.


interleukin-7 binding

Binding to interleukin-7.


methylation-dependent protein binding

Binding to a protein upon methylation of the target protein.


type 1 member 2 taste receptor binding

Binding to a type 1 member 2 taste receptor.


RHG protein domain binding

Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif).


type 2 melanin-concentrating hormone receptor binding

Binding to a type 2 melanin-concentrating hormone receptor.


interleukin-12 beta subunit binding

Binding to the beta subunit of interleukin-12.


muramyl dipeptide binding

Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan.


interleukin-3 binding

Binding to interleukin-3.


A1 adenosine receptor binding

Binding to an A1 adenosine receptor.


FH1 domain binding

Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain.


type 1F serotonin receptor binding

Binding to a type 1F serotonin receptor.


FMN-binding domain binding

Binding to the FMN-binding domain of a protein.


H4K20me3 modified histone binding

Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation.


myosin I binding

Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments.


signaling receptor binding

Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.


plastid PEP RNA polymerase core enzyme binding

Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit.


P2Y1 nucleotide receptor binding

Binding to a P2Y1 nucleotide receptor.


type 4 serotonin receptor binding

Binding to a type 4 serotonin receptor.


sterol-dependent protein binding

Binding to a protein or protein complex in the presence of sterols.


high molecular weight kininogen receptor binding

Binding to a high molecular weight kininogen receptor.


bone sialoprotein binding

Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin.


glucagon family peptide binding

Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP).


motilin receptor binding

Binding to a motilin receptor.


tachykinin receptor binding

Binding to a tachykinin receptor.


phosphopantetheine binding

Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate).


interleukin-24 binding

Binding to interleukin-24.


endothelin A receptor binding

Binding to an endothelin A receptor.


neurokinin receptor binding

Binding to a neurokinin receptor.


ghrelin receptor binding

Binding to a ghrelin receptor.


neuropeptide Y receptor binding

Binding to a neuropeptide Y receptor.


delta-type opioid receptor binding

Binding to a delta-type opioid receptor.


myosin II tail binding

Binding to the tail region of a myosin II heavy chain.


taste receptor binding

Binding to a taste receptor.


F-bar domain binding

Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins.


gastrin-releasing peptide receptor binding

Binding to a gastrin-releasing peptide receptor.


neurotensin receptor binding

Binding to a neurotensin receptor.


nociceptin receptor binding

Binding to a nociceptin receptor.


interleukin-5 binding

Binding to interleukin-5.


type 1 parathyroid hormone receptor binding

Binding to a type 1 parathyroid hormone receptor.


lutropin-choriogonadotropic hormone receptor binding

Binding to a lutropin-choriogonadotropic hormone receptor.


lipoamide binding

Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.


type 1 proteinase activated receptor binding

Binding to a type 1 proteinase activated receptor.


serpin family protein binding

Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors.


adipokinetic hormone receptor binding

Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


ubiquitin-dependent protein binding

Binding to a protein upon ubiquitination of the target protein.


alpha-latrotoxin receptor binding

Binding to an alpha-latrotoxin receptor.


CD154 receptor binding

Binding to CD154, a receptor found on the surface of some activated lymphocytes.


deaminase binding

Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3).


ganglioside GM3 binding

Binding to ganglioside GM3.


torso binding

Binding to a torso (tor) protein, a receptor tyrosine kinase.


type 2 orexin receptor binding

Binding to a type 2 orexin receptor.


BH4 domain binding

Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein.


B2 bradykinin receptor binding

Binding to a B2 bradykinin receptor.


antisigma factor binding

Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator.


kappa-type opioid receptor binding

Binding to a kappa-type opioid receptor.


type 1 neuropeptide Y receptor binding

Binding to a type 1 neuropeptide Y receptor.


H3K9me3 modified histone binding

Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation.


interleukin-16 binding

Binding to interleukin-16.


type 1A melatonin receptor binding

Binding to a type 1A melatonin receptor.


SET domain binding

Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation.


high molecular weight kininogen binding

Binding to a kininogen of high molecular mass.


TIMP family protein binding

Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family.


neuromedin B receptor binding

Binding to a neuromedin B receptor.


hemoglobin alpha binding

Binding to a hemoglobin alpha chain.


type 1 galanin receptor binding

Binding to a type 1 galanin receptor.


cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication

Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells.


RNA polymerase V core binding

Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing.


complement component C3dg binding

Binding to a C3dg product of the complement cascade.


small protein activating enzyme binding

Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme.


type 2 cannabinoid receptor binding

Binding to a type 2 cannabinoid receptor.


CNBH domain intrinsic ligand binding

Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide.


P2Y4 nucleotide receptor binding

Binding to a P2Y4 nucleotide receptor.


bacterial-type RNA polymerase holo enzyme binding

Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase.


thyrotropin-releasing hormone binding

Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system.


wishful thinking binding

Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor.


general transcription initiation factor binding

Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation.


Binding to succinate-semialdehyde dehydrogenase.


type 3 somatostatin receptor binding

Binding to a type 3 somatostatin receptor.


type-III dockerin domain binding

Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain.


calcitonin family binding

Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)).


type 5A serotonin receptor binding

Binding to a type 5A serotonin receptor.


RNA polymerase III core binding

Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.


FBXO family protein binding

Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction.


myosin head/neck binding

Binding to the head/neck region of a myosin heavy chain.


F-box domain binding

Binding to an F-box domain of a protein.


type 1 vasoactive intestinal polypeptide receptor binding

Binding to a type 1 vasoactive intestinal polypeptide receptor.


interleukin-35 binding

Binding to interleukin-35.


substance K receptor binding

Binding to a substance K receptor.


peroxisome membrane targeting sequence binding

Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane.


RNA polymerase IV core binding

Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production.


integrin binding involved in cell-matrix adhesion

Any integrin binding that occurs as part of the process of cell-matrix adhesion.


FHA domain binding

Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich.


P2Y9 nucleotide receptor binding

Binding to a P2Y9 nucleotide receptor.


splicing factor binding

Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA.


somatostatin receptor binding

Binding to a somatostatin receptor.


vasoactive intestinal polypeptide receptor binding

Binding to a vasoactive intestinal polypeptide receptor.


type 1E serotonin receptor binding

Binding to a type 1E serotonin receptor.


netrin receptor binding

Binding to a netrin receptor.


polo box domain specific binding

Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases.


myosin I light chain binding

Binding to a light chain of a myosin I complex.


type 2 angiotensin receptor binding

Binding to a type 2 angiotensin receptor.


H1 histamine receptor binding

Binding to a H1 histamine receptor.


A2A adenosine receptor binding

Binding to an A2A adenosine receptor.


interleukin-15 binding

Binding to interleukin-15.


calcitonin gene-related peptide binding

Binding to calcitonin gene-related peptide (CGRP).


MH1 domain binding

Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors.


EH domain binding

Binding to an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R.


BH2 domain binding

Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists.


chemokine (C-C motif) ligand 2 binding

Binding to chemokine (C-C motif) ligand 2.


myosin I head/neck binding

Binding to the head/neck region of a myosin I heavy chain.


type II interferon binding

Binding to type II interferon, also known as interferon-gamma.


melatonin receptor binding

Binding to a melatonin receptor.


ELYC domain binding

Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC.


amino-terminal vacuolar sorting propeptide binding

Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles.


beta-endorphin binding

Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin.


type 2 proteinase activated receptor binding

Binding to a type 2 proteinase activated receptor.


type 2 cysteinyl leukotriene receptor binding

Binding to a type 2 cysteinyl leukotriene receptor.


X11-like protein binding

Binding to X11-like protein, a neuron-specific adaptor protein.


type-I dockerin domain binding

Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain.


ubiquitination-like modification-dependent protein binding

Binding to a protein upon modification by a ubiquitin-like protein of the target protein.


Edg-5 sphingosine 1-phosphate receptor binding

Binding to an Edg-5 sphingosine 1-phosphate receptor.


G protein-coupled nucleotide receptor binding

Binding to a G protein-coupled (metabotropic) nucleotide receptor.


mono-ADP-D-ribose modification-dependent protein binding

Binding to a protein upon mono-ADP-ribosylation of the target protein.


protein binding

Binding to a protein.


modification-dependent protein binding

Binding to a protein upon post-translation modification of the target protein.