CBX1_HUMAN Chromobox protein homolog 1 (sprot)

A chromobox protein homolog 1 that is encoded in the genome of human.


SMAD3_HUMAN Mothers against decapentaplegic homolog 3 (sprot)

A smad3 that is encoded in the genome of human.


nuclear mineralocorticoid receptor binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to a nuclear mineralocorticoid receptor.


positive regulation of transforming growth factor beta3 production

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3.


paraxial mesoderm morphogenesis

The process in which the anatomical structures of the paraxial mesoderm are generated and organized.


negative regulation of lung blood pressure

The process that decreases the force with which blood travels through the lungs.


heteromeric SMAD protein complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.


HPCA_HUMAN Neuron-specific calcium-binding protein hippocalcin (sprot)

A neuron-specific calcium-binding protein hippocalcin that is encoded in the genome of human.


response to ketamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus.


response to Aroclor 1254

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus.


ARF1_HUMAN ADP-ribosylation factor 1 (sprot)

An ADP-ribosylation factor 1 that is encoded in the genome of human.


mitotic cleavage furrow ingression

Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed.


ARF5_HUMAN ADP-ribosylation factor 5 (sprot)

An ADP-ribosylation factor 5 that is encoded in the genome of human.


ERH_HUMAN Enhancer of rudimentary homolog (sprot)

An enhancer of rudimentary that is encoded in the genome of human.


RHOG_HUMAN Rho-related GTP-binding protein RhoG (sprot)

A Rho-related GTP-binding protein RhoG that is encoded in the genome of human.


RL19_HUMAN Large ribosomal subunit protein eL19 (sprot)

A 60S ribosomal protein L19 that is encoded in the genome of human.


SERF2_HUMAN Small EDRK-rich factor 2 (sprot)

A small EDRK-rich factor 2 that is encoded in the genome of human.


SRSF3_HUMAN Serine/arginine-rich splicing factor 3 (sprot)

A serine/arginine-rich splicing factor 3 that is encoded in the genome of human.


MXRA7_HUMAN Matrix-remodeling-associated protein 7 (sprot)

A matrix-remodeling-associated protein 7 that is encoded in the genome of human.


H33_HUMAN Histone H3.3 (sprot)

A histone H3.3 that is encoded in the genome of human.


SKOR1_HUMAN SKI family transcriptional corepressor 1 (sprot)

A ladybird homeobox corepressor 1 that is encoded in the genome of human.


FOXK1_HUMAN Forkhead box protein K1 (sprot)

A forkhead box protein K1 that is encoded in the genome of human.


RHG08_HUMAN Rho GTPase-activating protein 8 (sprot)

A Rho GTPase-activating protein 8 that is encoded in the genome of human.


PRR5_HUMAN Proline-rich protein 5 (sprot)

A protor-1 that is encoded in the genome of human.


HTD2_HUMAN Hydroxyacyl-thioester dehydratase type 2, mitochondrial (sprot)

A hydroxyacyl-thioester dehydratase type 2, mitochondrial that is encoded in the genome of human.


ZBED6_HUMAN Zinc finger BED domain-containing protein 6 (sprot)

A zinc finger BED domain-containing protein 6 that is encoded in the genome of human.


PR20E_HUMAN Proline-rich protein 20E (sprot)

A proline-rich protein 20E that is encoded in the genome of human.


PR20C_HUMAN Proline-rich protein 20C (sprot)

A proline-rich protein 20C that is encoded in the genome of human.


PR20D_HUMAN Proline-rich protein 20D (sprot)

A proline-rich protein 20D that is encoded in the genome of human.


CCZ1B_HUMAN Vacuolar fusion protein CCZ1 homolog B (sprot)

A vacuolar fusion protein CCZ1 homolog B that is encoded in the genome of human.


Mon1-Ccz1 complex

A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p.


CCZ1_HUMAN Vacuolar fusion protein CCZ1 homolog (sprot)

A vacuolar fusion protein CCZ1 homolog that is encoded in the genome of human.


TSG6_HUMAN Tumor necrosis factor-inducible gene 6 protein (sprot)

A tumor necrosis factor-inducible gene 6 protein that is encoded in the genome of human.


ENTK_HUMAN Enteropeptidase (sprot)

An enteropeptidase that is encoded in the genome of human.


SHC2_HUMAN SHC-transforming protein 2 (sprot)

An SHC-transforming protein 2 that is encoded in the genome of human.


DAB2_HUMAN Disabled homolog 2 (sprot)

A disabled homolog 2 that is encoded in the genome of human.


leading edge cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet.


MUC5A_HUMAN Mucin-5AC (sprot)

A mucin-5AC that is encoded in the genome of human.


FBLN2_HUMAN Fibulin-2 (sprot)

A fibulin-2 that is encoded in the genome of human.


IDD_HUMAN Integral membrane protein DGCR2/IDD (sprot)

An integral membrane protein DGCR2/IDD that is encoded in the genome of human.


VLDLR_HUMAN Very low-density lipoprotein receptor (sprot)

A very low-density lipoprotein receptor that is encoded in the genome of human.


reelin receptor activity

Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


PGBM_HUMAN Basement membrane-specific heparan sulfate proteoglycan core protein (sprot)

A basement membrane-specific heparan sulfate proteoglycan core protein that is encoded in the genome of human.


PKD1_HUMAN Polycystin-1 (sprot)

A polycystin-1 that is encoded in the genome of human.


mesonephric tubule development

The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros.


metanephric distal tubule morphogenesis

The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule.


cell-cell signaling by wnt

Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the recieving cell.


polycystin complex

A stable heterodimeric complex composed of polycystin-1 and polycystin-2.


cation channel complex

An ion channel complex through which cations pass.


LRP2_HUMAN Low-density lipoprotein receptor-related protein 2 (sprot)

A low-density lipoprotein receptor-related protein 2 that is encoded in the genome of human.


diol metabolic process

The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic.


neuron projection arborization

The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.


ZXDA_HUMAN Zinc finger X-linked protein ZXDA (sprot)

A zinc finger X-linked protein ZXDA that is encoded in the genome of human.


ZXDB_HUMAN Zinc finger X-linked protein ZXDB (sprot)

A zinc finger X-linked protein ZXDB that is encoded in the genome of human.


XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (sprot)

A baculoviral IAP repeat-containing protein 4 that is encoded in the genome of human.


endopeptidase regulator activity

Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.


copper ion homeostasis

Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell.


regulation of apoptosis involved in tissue homeostasis

Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue.


regulation of nucleotide-binding oligomerization domain containing signaling pathway

Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway.


RHG04_HUMAN Rho GTPase-activating protein 4 (sprot)

A Rho GTPase-activating protein 4 that is encoded in the genome of human.


EFNB1_HUMAN Ephrin-B1 (sprot)

An ephrin-B1 that is encoded in the genome of human.


FAM3A_HUMAN Protein FAM3A (sprot)

A protein FAM3A that is encoded in the genome of human.


negative regulation of antifungal innate immune response

Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response.


FGD1_HUMAN FYVE, RhoGEF and PH domain-containing protein 1 (sprot)

A FYVE, RhoGEF and PH domain-containing protein 1 that is encoded in the genome of human.


RBM10_HUMAN RNA-binding protein 10 (sprot)

An RNA-binding protein 10 that is encoded in the genome of human.


vascular associated smooth muscle cell apoptotic process

Any apoptotic process in a vascular associated smooth muscle cell.


FOXO4_HUMAN Forkhead box protein O4 (sprot)

A forkhead box protein O4 that is encoded in the genome of human.


RBM3_HUMAN RNA-binding protein 3 (sprot)

An RNA-binding protein 3 that is encoded in the genome of human.


ZN200_HUMAN Zinc finger protein 200 (sprot)

A zinc finger protein 200 that is encoded in the genome of human.


CP4F8_HUMAN Cytochrome P450 4F8 (sprot)

A cytochrome P450 4F8 that is encoded in the genome of human.


AT2C1_HUMAN Calcium-transporting ATPase type 2C member 1 (sprot)

A calcium-transporting ATPase type 2C member 1 that is encoded in the genome of human.


Golgi calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings.


Golgi calcium ion transport

The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus.


trans-Golgi network membrane organization

A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane.


AT11A_HUMAN Phospholipid-transporting ATPase IH (sprot)

A phospholipid-transporting ATPase IH that is encoded in the genome of human.


AT8B2_HUMAN Phospholipid-transporting ATPase ID (sprot)

A phospholipid-transporting ATPase ID that is encoded in the genome of human.


CYC_HUMAN Cytochrome c (sprot)

A cytochrome c, somatic that is encoded in the genome of human.


respirasome

The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.


2ABB_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (sprot)

A serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform that is encoded in the genome of human.


EM55_HUMAN 55 kDa erythrocyte membrane protein (sprot)

A 55 kDa erythrocyte membrane protein that is encoded in the genome of human.


regulation of neutrophil chemotaxis

Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


HXA4_HUMAN Homeobox protein Hox-A4 (sprot)

A homeobox protein Hox-A4 that is encoded in the genome of human.


TFAM_HUMAN Transcription factor A, mitochondrial (sprot)

A transcription factor A, mitochondrial that is encoded in the genome of human.


PIPNA_HUMAN Phosphatidylinositol transfer protein alpha isoform (sprot)

A phosphatidylinositol transfer protein alpha isoform that is encoded in the genome of human.


METK1_HUMAN S-adenosylmethionine synthase isoform type-1 (sprot)

An S-adenosylmethionine synthetase isoform type-1 that is encoded in the genome of human.


methionine catabolic process

The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.


S25A3_HUMAN Solute carrier family 25 member 3 (sprot)

A phosphate carrier protein, mitochondrial that is encoded in the genome of human.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in).


mitochondrial phosphate ion transmembrane transport

The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion.


VIGLN_HUMAN Vigilin (sprot)

A vigilin that is encoded in the genome of human.


TF2B_HUMAN Transcription initiation factor IIB (sprot)

A transcription initiation factor IIB that is encoded in the genome of human.


transcriptional start site selection at RNA polymerase II promoter

Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.


viral transcription

The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.


meiotic sister chromatid cohesion

The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis.


RNA polymerase II core complex assembly

The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex.


cell division site

The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.


HXC5_HUMAN Homeobox protein Hox-C5 (sprot)

A homeobox protein Hox-C5 that is encoded in the genome of human.


CDK3_HUMAN Cyclin-dependent kinase 3 (sprot)

A cyclin-dependent kinase 3 that is encoded in the genome of human.


CDKL1_HUMAN Cyclin-dependent kinase-like 1 (sprot)

A cyclin-dependent kinase-like 1 that is encoded in the genome of human.


CDK6_HUMAN Cyclin-dependent kinase 6 (sprot)

A cyclin-dependent kinase 6 that is encoded in the genome of human.


FBXO family protein binding

Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction.


cyclin D2-CDK6 complex

A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


CDK5_HUMAN Cyclin-dependent kinase 5 (sprot)

A cyclin-dependent kinase 5 that is encoded in the genome of human.


ErbB-2 class receptor binding

Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2.


cerebellar cortex formation

The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


protein kinase 5 complex

A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent.


CDK16_HUMAN Cyclin-dependent kinase 16 (sprot)

A cyclin-dependent kinase 16 that is encoded in the genome of human.


CDK17_HUMAN Cyclin-dependent kinase 17 (sprot)

A cyclin-dependent kinase 17 that is encoded in the genome of human.


PURA_HUMAN Transcriptional activator protein Pur-alpha (sprot)

A transcriptional activator protein Pur-alpha that is encoded in the genome of human.


dendritic transport of messenger ribonucleoprotein complex

The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites.


BORG5_HUMAN Cdc42 effector protein 1 (sprot)

A Cdc42 effector protein 1 that is encoded in the genome of human.


FANCC_HUMAN Fanconi anemia group C protein (sprot)

A Fanconi anemia group C protein that is encoded in the genome of human.


NDP_HUMAN Norrin (sprot)

A norrin that is encoded in the genome of human.


retinal pigment epithelium development

The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.


retina blood vessel maintenance

A retina homeostatic process preventing the degeneration of a retina blood vessel.


CLH1_HUMAN Clathrin heavy chain 1 (sprot)

A clathrin heavy chain 1 that is encoded in the genome of human.


HSF1_HUMAN Heat shock factor protein 1 (sprot)

A heat shock factor protein 1 that is encoded in the genome of human.


RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within.


translation elongation factor binding

Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation.


sequence-specific single stranded DNA binding

Binding to single-stranded DNA of a specific nucleotide composition.


cellular response to diamide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus.


cellular response to nitroglycerin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus.


response to hypobaric hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level).


NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit (sprot)

A nuclear factor NF-kappa-B p100 subunit that is encoded in the genome of human.


FKBP3_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP3 (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP3 that is encoded in the genome of human.


PLCB2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (sprot)

A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 that is encoded in the genome of human.


G-protein beta/gamma-subunit complex

The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange.


REEP5_HUMAN Receptor expression-enhancing protein 5 (sprot)

A receptor expression-enhancing protein 5 that is encoded in the genome of human.


regulation of intracellular transport

Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.


endoplasmic reticulum membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane.


DHSO_HUMAN Sorbitol dehydrogenase (sprot)

A sorbitol dehydrogenase that is encoded in the genome of human.


(R,R)-butanediol dehydrogenase activity

Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+.


L-iditol 2-dehydrogenase activity

Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.


D-xylulose reductase activity

Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH.


D-sorbitol dehydrogenase (acceptor) activity

Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor.


ribitol 2-dehydrogenase activity

Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH.


sorbitol catabolic process

The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group.


L-xylitol catabolic process

The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group.


L-xylitol metabolic process

The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets.


HNRPU_HUMAN Heterogeneous nuclear ribonucleoprotein U (sprot)

A heterogeneous nuclear ribonucleoprotein U that is encoded in the genome of human.


TFIIH-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


poly(C) RNA binding

Binding to a sequence of cytosine residues in an RNA molecule.


protein localization to spindle microtubule

A process in which a protein is transported to, or maintained in, a location within a spindle microtubule.


RNA localization to chromatin

A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin.


inactive sex chromosome

A sex chromosome that has been inactivated.


MYPC1_HUMAN Myosin-binding protein C, slow-type (sprot)

A myosin-binding protein C, slow-type that is encoded in the genome of human.


PSG9_HUMAN Pregnancy-specific beta-1-glycoprotein 9 (sprot)

A pregnancy-specific beta-1-glycoprotein 9 that is encoded in the genome of human.


tolerance induction dependent upon immune response

Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation.


transforming growth factor beta1 activation

The release of transforming growth factor beta1 (TGF-beta1) from its latent state.


PSG4_HUMAN Pregnancy-specific beta-1-glycoprotein 4 (sprot)

A pregnancy-specific beta-1-glycoprotein 4 that is encoded in the genome of human.


PSG6_HUMAN Pregnancy-specific beta-1-glycoprotein 6 (sprot)

A pregnancy-specific beta-1-glycoprotein 6 that is encoded in the genome of human.


ECT2L_HUMAN Epithelial cell-transforming sequence 2 oncogene-like (sprot)

An epithelial cell-transforming sequence 2 oncogene-like that is encoded in the genome of human.


B4GN1_HUMAN Beta-1,4 N-acetylgalactosaminyltransferase 1 (sprot)

A beta-1,4 N-acetylgalactosaminyltransferase 1 that is encoded in the genome of human.


Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide.


CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B (sprot)

A voltage-dependent N-type calcium channel subunit alpha-1B that is encoded in the genome of human.


IRF9_HUMAN Interferon regulatory factor 9 (sprot)

An interferon regulatory factor 9 that is encoded in the genome of human.


MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (sprot)

An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of human.


traversing start control point of mitotic cell cycle

A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.


cellular response to vitamin B1

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus.


negative regulation of signal transduction by p53 class mediator

Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator.


response to formaldehyde

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus.


BEX3_HUMAN Protein BEX3 (sprot)

A protein BEX3 that is encoded in the genome of human.


PLIN5_HUMAN Perilipin-5 (sprot)

A perilipin-5 that is encoded in the genome of human.


negative regulation of peroxisome proliferator activated receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.


PRCD_HUMAN Photoreceptor disk component PRCD (sprot)

A photoreceptor disk component PRCD that is encoded in the genome of human.


PDE1B_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (sprot)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B that is encoded in the genome of human.


U2AF1_HUMAN Splicing factor U2AF 35 kDa subunit (sprot)

A splicing factor U2AF 35 kDa subunit that is encoded in the genome of human.


SPTB2_HUMAN Spectrin beta chain, non-erythrocytic 1 (sprot)

A spectrin beta chain, non-erythrocytic 1 that is encoded in the genome of human.


central nervous system formation

The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.


TIAR_HUMAN Nucleolysin TIAR (sprot)

A nucleolysin TIAR that is encoded in the genome of human.


E2F1_HUMAN Transcription factor E2F1 (sprot)

A transcription factor E2F1 that is encoded in the genome of human.


INSM1_HUMAN Insulinoma-associated protein 1 (sprot)

An insulinoma-associated protein 1 that is encoded in the genome of human.


SET_HUMAN Protein SET (sprot)

A protein SET that is encoded in the genome of human.


negative regulation of histone acetylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.


IL9R_HUMAN Interleukin-9 receptor (sprot)

An interleukin-9 receptor that is encoded in the genome of human.


interleukin-9 receptor activity

Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


SCN7A_HUMAN Sodium channel protein type 7 subunit alpha (sprot)

A sodium channel protein type 7 subunit alpha that is encoded in the genome of human.


SRSF2_HUMAN Serine/arginine-rich splicing factor 2 (sprot)

A splicing factor, arginine/serine-rich 2 that is encoded in the genome of human.


interchromatin granule

A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs).


CD83_HUMAN CD83 antigen (sprot)

A CD83 molecule that is encoded in the genome of human.


FOXK2_HUMAN Forkhead box protein K2 (sprot)

A forkhead box protein K2 that is encoded in the genome of human.


RUNX1_HUMAN Runt-related transcription factor 1 (sprot)

A runt-related transcription factor 1 that is encoded in the genome of human.


regulation of connective tissue replacement

Any process that modulates the frequency, rate or extent of connective tissue replacement.


core-binding factor complex

A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit.


RELB_HUMAN Transcription factor RelB (sprot)

A transcription factor RelB that is encoded in the genome of human.


lymphocyte differentiation

The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.


IL5RA_HUMAN Interleukin-5 receptor subunit alpha (sprot)

An interleukin-5 receptor subunit alpha that is encoded in the genome of human.


FCERB_HUMAN High affinity immunoglobulin epsilon receptor subunit beta (sprot)

A high affinity immunoglobulin epsilon receptor subunit beta that is encoded in the genome of human.


GALK2_HUMAN N-acetylgalactosamine kinase (sprot)

An N-acetylgalactosamine kinase that is encoded in the genome of human.


N-acetylgalactosamine kinase activity

Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate.


AMPD3_HUMAN AMP deaminase 3 (sprot)

An AMP deaminase 3 that is encoded in the genome of human.


AMPD2_HUMAN AMP deaminase 2 (sprot)

An AMP deaminase 2 that is encoded in the genome of human.


IMP biosynthetic process

The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate.


cyclic purine nucleotide metabolic process

The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine.


MLRA_HUMAN Myosin regulatory light chain 2, atrial isoform (sprot)

A myosin regulatory light chain 2, atrial isoform that is encoded in the genome of human.


PMP22_HUMAN Peripheral myelin protein 22 (sprot)

A peripheral myelin protein 22 that is encoded in the genome of human.


A di-N-acetylchitobiase that is encoded in the genome of human.


FABP5_HUMAN Fatty acid-binding protein 5 (sprot)

A fatty acid-binding protein 5 that is encoded in the genome of human.


regulation of prostaglandin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


regulation of retrograde trans-synaptic signaling by endocanabinoid

Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid.


ANK2_HUMAN Ankyrin-2 (sprot)

An ankyrin-2 that is encoded in the genome of human.


protein localization to M-band

Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere.


protein localization to T-tubule

A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.


atrial cardiac muscle cell to AV node cell communication

The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


SA node cell to atrial cardiac muscle cell communication

The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


positive regulation of calcium ion transmembrane transporter activity

Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity.


CAP1_HUMAN Adenylyl cyclase-associated protein 1 (sprot)

An adenylyl cyclase-associated protein 1 that is encoded in the genome of human.


DEF5_HUMAN Defensin alpha 5 (sprot)

A protein that is a translation product of the DEFA5 gene in human.


positive regulation of membrane permeability

Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane.


DEF6_HUMAN Defensin-6 (sprot)

A protein that is a translation product of the DEFA6 gene in human.


TSPY1_HUMAN Testis-specific Y-encoded protein 1 (sprot)

A testis-specific Y-encoded protein 1 that is encoded in the genome of human.


MYT1_HUMAN Myelin transcription factor 1 (sprot)

A myelin transcription factor 1 that is encoded in the genome of human.


FLI1_HUMAN Friend leukemia integration 1 transcription factor (sprot)

A Friend leukemia integration 1 transcription factor that is encoded in the genome of human.


K22O_HUMAN Keratin, type II cytoskeletal 2 oral (sprot)

A keratin, type II cytoskeletal 2 oral that is encoded in the genome of human.


sebaceous gland development

The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure.


HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytoplasmic (sprot)

A hydroxymethylglutaryl-CoA synthase, cytoplasmic that is encoded in the genome of human.


IFM3_HUMAN Interferon-induced transmembrane protein 3 (sprot)

An interferon-induced transmembrane protein that is a translation product of the IFITM3 gene in human.


IFM2_HUMAN Interferon-induced transmembrane protein 2 (sprot)

An interferon-induced transmembrane protein that is a translation product of the IFITM2 gene in human.


ILRL1_HUMAN Interleukin-1 receptor-like 1 (sprot)

An interleukin-1 receptor-like 1 that is encoded in the genome of human.


interleukin-33 receptor activity

Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


LAT1_HUMAN Large neutral amino acids transporter small subunit 1 (sprot)

A large neutral amino acids transporter small subunit 1 that is encoded in the genome of human.


L-tryptophan transmembrane transporter activity

Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid.


cellular response to L-arginine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus.


L-tryptophan transmembrane transport

The directed movement of L-tryptophan across a membrane.


positive regulation of leucine import across plasma membrane

Any process that activates or increases the frequency, rate or extent of leucine import across plasma membrane.


NC2B_HUMAN Protein Dr1 (sprot)

A protein Dr1 that is encoded in the genome of human.


TFAP4_HUMAN Transcription factor AP-4 (sprot)

A transcription factor AP-4 that is encoded in the genome of human.


CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1D that is encoded in the genome of human.


ACTHR_HUMAN Adrenocorticotropic hormone receptor (sprot)

An adrenocorticotropic hormone receptor that is encoded in the genome of human.


corticotropin receptor activity

Combining with corticotropin to initiate a change in cell activity.


MSHR_HUMAN Melanocyte-stimulating hormone receptor (sprot)

A melanocyte-stimulating hormone receptor that is encoded in the genome of human.


UV-damage excision repair

A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).


positive regulation of feeding behavior

Any process that activates or increases the frequency, rate or extent of feeding behavior.


FMO1_HUMAN Flavin-containing monooxygenase 1 (sprot)

A flavin-containing monooxygenase 1 that is encoded in the genome of human.


EXOSX_HUMAN Exosome component 10 (sprot)

An exosome component 10 that is encoded in the genome of human.


RNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.


CUT catabolic process

The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs).


nuclear polyadenylation-dependent rRNA catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA.


nucleolar exosome (RNase complex)

A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.


OTUD4_HUMAN OTU domain-containing protein 4 (sprot)

An OTU domain-containing protein 4 that is encoded in the genome of human.


regulation of protein K48-linked deubiquitination

Any process that modulates the frequency, rate or extent of protein K48-linked deubiquitination.


PFKAP_HUMAN ATP-dependent 6-phosphofructokinase, platelet type (sprot)

An ATP-dependent 6-phosphofructokinase, platelet type that is encoded in the genome of human.


AT2B2_HUMAN Plasma membrane calcium-transporting ATPase 2 (sprot)

A plasma membrane calcium-transporting ATPase 2 that is encoded in the genome of human.


P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration

A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration.


SATB1_HUMAN DNA-binding protein SATB1 (sprot)

A DNA-binding protein SATB1 that is encoded in the genome of human.


XPC_HUMAN DNA repair protein complementing XP-C cells (sprot)

A DNA repair protein complementing XP-C cells that is encoded in the genome of human.


heteroduplex DNA loop binding

Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration.


EWS_HUMAN RNA-binding protein EWS (sprot)

An RNA-binding protein EWS that is encoded in the genome of human.


CDR2_HUMAN Cerebellar degeneration-related protein 2 (sprot)

A cerebellar degeneration-related protein 2 that is encoded in the genome of human.


PO4F1_HUMAN POU domain, class 4, transcription factor 1 (sprot)

A POU domain, class 4, transcription factor 1 that is encoded in the genome of human.


cell migration in hindbrain

The orderly movement of a cell that will reside in the hindbrain.


proprioception involved in equilibrioception

The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity.


PO5F1_HUMAN POU domain, class 5, transcription factor 1 (sprot)

A POU domain, class 5, transcription factor 1 that is encoded in the genome of human.


SPIB_HUMAN Transcription factor Spi-B (sprot)

A transcription factor Spi-B that is encoded in the genome of human.


BNC1_HUMAN Zinc finger protein basonuclin-1 (sprot)

A zinc finger protein basonuclin-1 that is encoded in the genome of human.


CO4A3_HUMAN Collagen alpha-3(IV) chain (sprot)

A collagen alpha-3(IV) chain that is encoded in the genome of human.


SC6A3_HUMAN Sodium-dependent dopamine transporter (sprot)

A sodium-dependent dopamine transporter that is encoded in the genome of human.


amine binding

Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group.


OCRL_HUMAN Inositol polyphosphate 5-phosphatase OCRL (sprot)

An inositol polyphosphate 5-phosphatase OCRL that is encoded in the genome of human.


Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.


inositol phosphate phosphatase activity

Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate.


PLCB3_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (sprot)

A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 that is encoded in the genome of human.


ROR1_HUMAN Inactive tyrosine-protein kinase transmembrane receptor ROR1 (sprot)

A tyrosine-protein kinase transmembrane receptor ROR1 that is encoded in the genome of human.


ROR2_HUMAN Tyrosine-protein kinase transmembrane receptor ROR2 (sprot)

A tyrosine-protein kinase transmembrane receptor ROR2 that is encoded in the genome of human.


regulation of synaptic signaling by nitric oxide

Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide.


TAGL_HUMAN Transgelin (sprot)

A transgelin that is encoded in the genome of human.


AK17A_HUMAN A-kinase anchor protein 17A (sprot)

An A-kinase anchor protein 17A that is encoded in the genome of human.


MYL5_HUMAN Myosin light chain 5 (sprot)

A myosin light chain 5 that is encoded in the genome of human.


MEF2A_HUMAN Myocyte-specific enhancer factor 2A (sprot)

A myocyte-specific enhancer factor 2A that is encoded in the genome of human.


mitochondrion distribution

Any process that establishes the spatial arrangement of mitochondria between and within cells.


ERK5 cascade

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.


MEF2B_HUMAN Myocyte-specific enhancer factor 2B (sprot)

A myocyte-specific enhancer factor 2B that is encoded in the genome of human.


NAAA_HUMAN N-acylethanolamine-hydrolyzing acid amidase (sprot)

An N-acylethanolamine-hydrolyzing acid amidase that is encoded in the genome of human.


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.


Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid.


ceramidase activity

Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid.


N-acylethanolamine metabolic process

The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group.


SP2_HUMAN Transcription factor Sp2 (sprot)

A transcription factor Sp2 that is encoded in the genome of human.


RHAG_HUMAN Ammonium transporter Rh type A (sprot)

An ammonium transporter Rh type A that is encoded in the genome of human.


methylammonium transmembrane transporter activity

Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other.


leak channel activity

Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.


GCYA1_HUMAN Guanylate cyclase soluble subunit alpha-1 (sprot)

A guanylate cyclase soluble subunit alpha-1 that is encoded in the genome of human.


retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission

Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.


guanylate cyclase complex, soluble

Complex that possesses guanylate cyclase activity and is not bound to a membrane.


PYRD_HUMAN Dihydroorotate dehydrogenase (quinone), mitochondrial (sprot)

A dihydroorotate dehydrogenase (quinone), mitochondrial that is encoded in the genome of human.


dihydroorotate dehydrogenase (quinone) activity

(S)-dihydroorotate + a quinone = orotate + a quinol.


GCYB1_HUMAN Guanylate cyclase soluble subunit beta-1 (sprot)

A guanylate cyclase soluble subunit beta-1 that is encoded in the genome of human.


cytidylate cyclase activity

Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+.


trans-synaptic signaling by nitric oxide, modulating synaptic transmission

Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse.


KPCE_HUMAN Protein kinase C epsilon type (sprot)

A protein kinase C epsilon that is encoded in the genome of human.


TRAM-dependent toll-like receptor 4 signaling pathway

The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


positive regulation of cellular glucuronidation

Any process that activates or increases the frequency, rate or extent of cellular glucuronidation.


RHD_HUMAN Blood group Rh(D) polypeptide (sprot)

A blood group Rh(D) polypeptide that is encoded in the genome of human.


ODO1_HUMAN 2-oxoglutarate dehydrogenase complex component E1 (sprot)

A 2-oxoglutarate dehydrogenase complex component E1 that is encoded in the genome of human.


oxoglutarate dehydrogenase (succinyl-transferring) activity

Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2.


oxoglutarate dehydrogenase (NAD+) activity

Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH.


cerebellar cortex development

The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


CX6A2_HUMAN Cytochrome c oxidase subunit 6A2, mitochondrial (sprot)

A cytochrome c oxidase subunit 6A2, mitochondrial that is encoded in the genome of human.


TNR17_HUMAN Tumor necrosis factor receptor superfamily member 17 (sprot)

A tumor necrosis factor receptor superfamily member 17 that is encoded in the genome of human.


CENPE_HUMAN Centromere-associated protein E (sprot)

A centromere-associated protein E that is encoded in the genome of human.


mitotic chromosome movement towards spindle pole

The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.


microtubule plus-end directed mitotic chromosome migration

The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression.


lateral attachment of mitotic spindle microtubules to kinetochore

The cell cycle process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate).


KIF23_HUMAN Kinesin-like protein KIF23 (sprot)

A kinesin-like protein KIF23 that is encoded in the genome of human.


centralspindlin complex

A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).


CNTN2_HUMAN Contactin-2 (sprot)

A contactin-2 that is encoded in the genome of human.


reduction of food intake in response to dietary excess

An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients.


clustering of voltage-gated potassium channels

The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode.


establishment of protein localization to juxtaparanode region of axon

The directed movement of a protein to the juxtaparanode region of an axon.


presynaptic membrane organization

A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.


MMSA_HUMAN Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (sprot)

A methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial that is encoded in the genome of human.


methylmalonate-semialdehyde dehydrogenase (acylating) activity

Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.


thymine catabolic process

The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.


valine metabolic process

The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.


thymine metabolic process

The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.


NRG1_HUMAN Pro-neuregulin-1, membrane-bound isoform (sprot)

A pro-neuregulin-1, membrane-bound isoform that is encoded in the genome of human.


ERBB3 signaling pathway

The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission.


positive regulation of striated muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.


CP27A_HUMAN Sterol 26-hydroxylase, mitochondrial (sprot)

A cytochrome P450 27, mitochondrial that is encoded in the genome of human.


cholesterol 26-hydroxylase activity

Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol.


Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate.


Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH.


Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O.


PLGB_HUMAN Plasminogen-like protein B (sprot)

A plasminogen-like protein B that is encoded in the genome of human.


BDH_HUMAN D-beta-hydroxybutyrate dehydrogenase, mitochondrial (sprot)

A D-beta-hydroxybutyrate dehydrogenase, mitochondrial that is encoded in the genome of human.


Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH.


matrix side of mitochondrial inner membrane

The side (leaflet) of the mitochondrial inner membrane that faces the matrix.


ID2_HUMAN DNA-binding protein inhibitor ID-2 (sprot)

A DNA-binding protein inhibitor ID-2 that is encoded in the genome of human.


epithelial cell differentiation involved in mammary gland alveolus development

The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.


endodermal digestive tract morphogenesis

The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.


SEMG2_HUMAN Semenogelin-2 (sprot)

A semenogelin-2 that is encoded in the genome of human.


ZNF45_HUMAN Zinc finger protein 45 (sprot)

A zinc finger protein 45 that is encoded in the genome of human.


CO7A1_HUMAN Collagen alpha-1(VII) chain (sprot)

A collagen alpha-1(VII) chain that is encoded in the genome of human.


collagen type VII trimer

A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin.


APBA1_HUMAN Amyloid-beta A4 precursor protein-binding family A member 1 (sprot)

An amyloid-beta A4 precursor protein-binding family A member 1 that is encoded in the genome of human.


DSG1_HUMAN Desmoglein-1 (sprot)

A desmoglein-1 that is encoded in the genome of human.


SP4_HUMAN Transcription factor Sp4 (sprot)

A transcription factor Sp4 that is encoded in the genome of human.


SP3_HUMAN Transcription factor Sp3 (sprot)

A transcription factor Sp3 that is encoded in the genome of human.


DSC2_HUMAN Desmocollin-2 (sprot)

A desmocollin-2 that is encoded in the genome of human.


cardiac muscle cell-cardiac muscle cell adhesion

The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules.


MUC3A_HUMAN Mucin-3A (sprot)

A mucin-3A that is encoded in the genome of human.


OC90_HUMAN Otoconin-90 (sprot)

An otoconin-90 that is encoded in the genome of human.


ID3_HUMAN DNA-binding protein inhibitor ID-3 (sprot)

A DNA-binding protein inhibitor ID-3 that is encoded in the genome of human.


leptomycin B binding

Binding to leptomycin B.


cellular response to leptomycin B

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus.


H11_HUMAN Histone H1.1 (sprot)

A histone H1.1 that is encoded in the genome of human.


RL18A_HUMAN Large ribosomal subunit protein eL20 (sprot)

A 60S ribosomal protein L18a that is encoded in the genome of human.


PAX5_HUMAN Paired box protein Pax-5 (sprot)

A paired box protein PAX-5 that is encoded in the genome of human.


IRF8_HUMAN Interferon regulatory factor 8 (sprot)

An interferon regulatory factor 8 that is encoded in the genome of human.


plasmacytoid dendritic cell differentiation

The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell.


HEN1_HUMAN Helix-loop-helix protein 1 (sprot)

A helix-loop-helix protein 1 that is encoded in the genome of human.


HEN2_HUMAN Helix-loop-helix protein 2 (sprot)

A helix-loop-helix protein 2 that is encoded in the genome of human.


male mating behavior

The specific behavior of a male organism that is associated with reproduction.


CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1 (sprot)

A voltage-dependent L-type calcium channel subunit beta-1 that is encoded in the genome of human.


GHRHR_HUMAN Growth hormone-releasing hormone receptor (sprot)

A growth hormone-releasing hormone receptor that is encoded in the genome of human.


growth hormone-releasing hormone receptor activity

Combining with growth hormone-releasing hormone to initiate a change in cell activity.


regulation of intracellular steroid hormone receptor signaling pathway

Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


multicellular organismal reproductive process

The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.


somatotropin secreting cell development

The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.


GCNT1_HUMAN Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (sprot)

A beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase that is encoded in the genome of human.


O-glycan processing, core 2

The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc.


GUC2A_HUMAN Guanylin (sprot)

A guanylin that is encoded in the genome of human.


guanylate cyclase activator activity

Binds to and increases the activity of guanylate cyclase.


MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (sprot)

A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of human.


TIE2_HUMAN Angiopoietin-1 receptor (sprot)

An angiopoietin-1 receptor that is encoded in the genome of human.


regulation of establishment or maintenance of cell polarity

Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.


M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 (sprot)

A mitogen-activated protein kinase kinase kinase 10 that is encoded in the genome of human.


FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4 (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP4 that is encoded in the genome of human.


steroid hormone receptor complex assembly

The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor.


negative regulation of microtubule polymerization or depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.


male sex differentiation

The establishment of the sex of a male organism by physical differentiation.


PLOD1_HUMAN Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (sprot)

A procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 that is encoded in the genome of human.


MUC2_HUMAN Mucin-2 (sprot)

A mucin-2 that is encoded in the genome of human.


detoxification of copper ion

Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion.


inner mucus layer

The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria.


outer mucus layer

The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria.


NUCB1_HUMAN Nucleobindin-1 (sprot)

A nucleobindin-1 that is encoded in the genome of human.


RASF7_HUMAN Ras association domain-containing protein 7 (sprot)

A Ras association domain-containing protein 7 that is encoded in the genome of human.


GUC2D_HUMAN Retinal guanylyl cyclase 1 (sprot)

A retinal guanylyl cyclase 1 that is encoded in the genome of human.


RL6_HUMAN Large ribosomal subunit protein eL6 (sprot)

A 60S ribosomal protein L6 that is encoded in the genome of human.


TOP2B_HUMAN DNA topoisomerase 2-beta (sprot)

A DNA topoisomerase 2-beta that is encoded in the genome of human.


CP4AB_HUMAN Cytochrome P450 4A11 (sprot)

A cytochrome P450 4A11 that is encoded in the genome of human.


oxylipin biosynthetic process

The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.


CREB5_HUMAN Cyclic AMP-responsive element-binding protein 5 (sprot)

A cyclic AMP-responsive element-binding protein 5 that is encoded in the genome of human.


AKA12_HUMAN A-kinase anchor protein 12 (sprot)

An A-kinase anchor protein 12 that is encoded in the genome of human.


regulation of protein kinase C signaling

Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.


positive regulation of oligodendrocyte apoptotic process

Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process.


PAX2_HUMAN Paired box protein Pax-2 (sprot)

A paired box protein Pax-2 that is encoded in the genome of human.


pronephric field specification

The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop.


optic chiasma development

The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature.


negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros.


negative regulation of apoptotic process involved in metanephric collecting duct development

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development.


negative regulation of apoptotic process involved in metanephric nephron tubule development

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development.


positive regulation of metanephric DCT cell differentiation

Any process that activates or increases the frequency, rate or extent of metanephric DCT cell differentiation.


positive regulation of optic nerve formation

Any process that activates or increases the frequency, rate or extent of optic nerve formation.


M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate carrier protein (sprot)

A mitochondrial 2-oxoglutarate/malate carrier protein that is encoded in the genome of human.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out).


alpha-ketoglutarate transport

The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


FHR3_HUMAN Complement factor H-related protein 3 (sprot)

A complement factor H-related protein 3 that is encoded in the genome of human.


DYST_HUMAN Dystonin (sprot)

A dystonin that is encoded in the genome of human.


H zone

A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments.


GSTM4_HUMAN Glutathione S-transferase Mu 4 (sprot)

A glutathione S-transferase mu 4 that is encoded in the genome of human.


HHEX_HUMAN Hematopoietically-expressed homeobox protein HHEX (sprot)

A hematopoietically-expressed homeobox protein HHEX that is encoded in the genome of human.


regulation of leukocyte proliferation

Any process that modulates the frequency, rate or extent of leukocyte proliferation.


PO3F1_HUMAN POU domain, class 3, transcription factor 1 (sprot)

A POU domain, class 3, transcription factor 1 that is encoded in the genome of human.


CREM_HUMAN cAMP-responsive element modulator (sprot)

A cAMP-responsive element modulator that is encoded in the genome of human.


ENL_HUMAN Protein ENL (sprot)

A protein ENL that is encoded in the genome of human.


MECOM_HUMAN Histone-lysine N-methyltransferase MECOM (sprot)

A histone-lysine N-methyltransferase MECOM that is encoded in the genome of human.


histone H3K9me2 methyltransferase activity

Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.


histone H3K9 monomethyltransferase activity

Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me.


GNA12_HUMAN Guanine nucleotide-binding protein subunit alpha-12 (sprot)

A guanine nucleotide-binding protein subunit alpha-12 that is encoded in the genome of human.


CAV1_HUMAN Caveolin-1 (sprot)

A caveolin-1 that is encoded in the genome of human.


inward rectifier potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.


intracellular nitric oxide homeostasis

A homeostatic process involved in the maintenance of a steady state level of nitric oxide within a cell.


protein localization to plasma membrane raft

A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft.


regulation of peptidase activity

Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.


negative regulation of peptidyl-tyrosine autophosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.


negative regulation of inward rectifier potassium channel activity

Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity.


ACY1_HUMAN Aminoacylase-1 (sprot)

An aminoacylase-1 that is encoded in the genome of human.


KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (sprot)

A histone-lysine N-methyltransferase 2A that is encoded in the genome of human.


Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein].


TGBR3_HUMAN Transforming growth factor beta receptor type 3 (sprot)

A TGF-beta receptor type-3 that is encoded in the genome of human.


transforming growth factor beta receptor activity, type III

Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.


transforming growth factor beta receptor complex assembly

The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex.


definitive erythrocyte differentiation

Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis.


epicardium-derived cardiac fibroblast cell development

The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules.


TNAP2_HUMAN Tumor necrosis factor alpha-induced protein 2 (sprot)

A tumor necrosis factor alpha-induced protein 2 that is encoded in the genome of human.


PPARD_HUMAN Peroxisome proliferator-activated receptor delta (sprot)

A peroxisome proliferator-activated receptor delta that is encoded in the genome of human.


linoleic acid binding

Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid.


positive regulation of fat cell proliferation

Any process that activates or increases the rate or extent of fat cell proliferation.


CENPC_HUMAN Centromere protein C (sprot)

A centromere protein C that is encoded in the genome of human.


LMNB2_HUMAN Lamin-B2 (sprot)

A lamin-B2 that is encoded in the genome of human.


PTPS_HUMAN 6-pyruvoyl tetrahydrobiopterin synthase (sprot)

A 6-pyruvoyl tetrahydrobiopterin synthase that is encoded in the genome of human.


Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate.


ROM1_HUMAN Rod outer segment membrane protein 1 (sprot)

A rod outer segment membrane protein 1 that is encoded in the genome of human.


TFF2_HUMAN Trefoil factor 2 (sprot)

A trefoil factor 2 that is encoded in the genome of human.


UPAR_HUMAN Urokinase plasminogen activator surface receptor (sprot)

A urokinase plasminogen activator surface receptor that is encoded in the genome of human.


urokinase plasminogen activator receptor activity

Combining with the urokinase plasminogen activator to initiate a change in cell activity.


KIME_HUMAN Mevalonate kinase (sprot)

A mevalonate kinase that is encoded in the genome of human.


mevalonate kinase activity

Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+.


isopentenyl diphosphate biosynthetic process, mevalonate pathway

The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.


PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (sprot)

A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of human.


parathyroid hormone receptor activity

Combining with parathyroid hormone to initiate a change in cell activity.


ERCC6_HUMAN DNA excision repair protein ERCC-6 (sprot)

A DNA excision repair protein ERCC-6 that is encoded in the genome of human.


TAP1_HUMAN Antigen peptide transporter 1 (sprot)

An antigen peptide transporter 1 that is encoded in the genome of human.


peptide transmembrane transporter activity

Enables the transfer of a peptide from one side of a membrane to the other.


ABC-type peptide antigen transporter activity

Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate.


cytosol to endoplasmic reticulum transport

The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell.


TAP complex

A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum.


TAP2_HUMAN Antigen peptide transporter 2 (sprot)

An antigen peptide transporter 2 that is encoded in the genome of human.


tapasin binding

Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules.


antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


peptide antigen transport

The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.


FHR1_HUMAN Complement factor H-related protein 1 (sprot)

A complement factor H-related protein 1 that is encoded in the genome of human.


COAA1_HUMAN Collagen alpha-1(X) chain (sprot)

A collagen alpha-1(X) chain that is encoded in the genome of human.


collagen type X trimer

A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets).


CEBPZ_HUMAN CCAAT/enhancer-binding protein zeta (sprot)

A CCAAT/enhancer-binding protein zeta that is encoded in the genome of human.


KCNC4_HUMAN Potassium voltage-gated channel subfamily C member 4 (sprot)

A voltage-gated potassium channel KCNC4 that is encoded in the genome of human.


EVX2_HUMAN Homeobox even-skipped homolog protein 2 (sprot)

A homeobox even-skipped homolog protein 2 that is encoded in the genome of human.


ZNF85_HUMAN Zinc finger protein 85 (sprot)

A zinc finger protein 85 that is encoded in the genome of human.


ZN117_HUMAN Zinc finger protein 117 (sprot)

A zinc finger protein 117 that is encoded in the genome of human.


HSF2_HUMAN Heat shock factor protein 2 (sprot)

A heat shock factor protein 2 that is encoded in the genome of human.


ZNF92_HUMAN Zinc finger protein 92 (sprot)

A zinc finger protein 92 that is encoded in the genome of human.


ZNF90_HUMAN Zinc finger protein 90 (sprot)

A zinc finger protein 90 that is encoded in the genome of human.


ARI5A_HUMAN AT-rich interactive domain-containing protein 5A (sprot)

An AT-rich interactive domain-containing protein 5A that is encoded in the genome of human.


PRB3_HUMAN Basic salivary proline-rich protein 3 (sprot)

A basic salivary proline-rich protein 3 that is encoded in the genome of human.


TF65_HUMAN Transcription factor p65 (sprot)

A transcription factor p65 that is encoded in the genome of human.


acetaldehyde metabolic process

The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.


postsynapse to nucleus signaling pathway

The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).


NF-kappaB p50/p65 complex

A heterodimer of NF-kappa B p50 and p65 subunits.


UBXN1_HUMAN UBX domain-containing protein 1 (sprot)

A UBX domain-containing protein 1 that is encoded in the genome of human.


K6-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein.


proteasome regulatory particle binding

Binding to a proteasome regulatory particle.


negative regulation of protein K48-linked deubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein K48-linked deubiquitination.


negative regulation of ubiquitin-specific protease activity

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity.


GLGB_HUMAN 1,4-alpha-glucan-branching enzyme (sprot)

A 1,4-alpha-glucan-branching enzyme that is encoded in the genome of human.


1,4-alpha-glucan branching enzyme activity

Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.


hydrolase activity, hydrolyzing O-glycosyl compounds

Catalysis of the hydrolysis of any O-glycosyl bond.


1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)

Catalysis of the reaction: a glucosylated glycogenin = a glycogen.


FOLH1_HUMAN Glutamate carboxypeptidase 2 (sprot)

A glutamate carboxypeptidase 2 that is encoded in the genome of human.


Ac-Asp-Glu binding

Binding to Ac-Asp-Glu.


Binding to tetrahydrofolyl-poly(glutamate) polymer.


C-terminal protein deglutamylation

The removal of a C-terminal, gene-encoded glutamate residue from a protein.


IF4G1_HUMAN Eukaryotic translation initiation factor 4 gamma 1 (sprot)

A eukaryotic translation initiation factor 4 gamma 1 that is encoded in the genome of human.


positive regulation of eukaryotic translation initiation factor 4F complex assembly

Any process that activates or increases the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly.


positive regulation of mRNA cap binding

Any process that activates or increases the frequency, rate or extent of mRNA cap binding.


regulation of polysome binding

Any process that modulates the frequency, rate or extent of polysome binding.


ATP7A_HUMAN Copper-transporting ATPase 1 (sprot)

A copper-transporting ATPase 1 that is encoded in the genome of human.


superoxide dismutase copper chaperone activity

A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity.


tryptophan metabolic process

The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.


peptidyl-lysine modification

The modification of peptidyl-lysine.


negative regulation of iron ion transmembrane transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore.


epinephrine metabolic process

The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.


elastin biosynthetic process

The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries.


copper ion export

The directed movement of copper ions out of a cell or organelle.


positive regulation of response to wounding

Any process that activates or increases the frequency, rate or extent of response to wounding.


P_HUMAN P protein (sprot)

A P protein that is encoded in the genome of human.


intracellular chloride channel activity

Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


lysosomal lumen pH elevation

Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.


K1C17_HUMAN Keratin, type I cytoskeletal 17 (sprot)

A keratin, type I cytoskeletal 17 that is encoded in the genome of human.


NOTC2_HUMAN Neurogenic locus notch homolog protein 2 (sprot)

A neurogenic locus notch homolog protein 2 that is encoded in the genome of human.


cholangiocyte proliferation

The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water.


regulation of osteoclast development

Any process that modulates the frequency, rate or extent of osteoclast development.


TLE1_HUMAN Transducin-like enhancer protein 1 (sprot)

A transducin-like enhancer protein 1 that is encoded in the genome of human.


TLE2_HUMAN Transducin-like enhancer protein 2 (sprot)

A transducin-like enhancer protein 2 that is encoded in the genome of human.


TLE3_HUMAN Transducin-like enhancer protein 3 (sprot)

A transducin-like enhancer protein 3 that is encoded in the genome of human.


TLE4_HUMAN Transducin-like enhancer protein 4 (sprot)

A transducin-like enhancer protein 4 that is encoded in the genome of human.


EMX1_HUMAN Homeobox protein EMX1 (sprot)

A homeobox protein EMX1 that is encoded in the genome of human.


EMX2_HUMAN Homeobox protein EMX2 (sprot)

A homeobox protein EMX2 that is encoded in the genome of human.


HGFA_HUMAN Hepatocyte growth factor activator (sprot)

A hepatocyte growth factor activator that is encoded in the genome of human.


KPCT_HUMAN Protein kinase C theta type (sprot)

A protein kinase C theta type that is encoded in the genome of human.


positive regulation of T-helper 2 cell activation

Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation.


LGUL_HUMAN Lactoylglutathione lyase (sprot)

A lactoylglutathione lyase that is encoded in the genome of human.


lactoylglutathione lyase activity

Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.


methylglyoxal metabolic process

The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.


ACVR1_HUMAN Activin receptor type-1 (sprot)

An activin receptor type-1 that is encoded in the genome of human.


endocardial cushion cell fate commitment

The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell.


AK1C1_HUMAN Aldo-keto reductase family 1 member C1 (sprot)

An aldo-keto reductase family 1 member C1 that is encoded in the genome of human.


Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + H+ + NADPH.


steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative.


androsterone dehydrogenase (B-specific) activity

Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+.


SSBP_HUMAN Single-stranded DNA-binding protein, mitochondrial (sprot)

A single-stranded DNA-binding protein, mitochondrial that is encoded in the genome of human.


positive regulation of mitochondrial DNA replication

Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.


ACHE_HUMAN Acetylcholine receptor subunit epsilon (sprot)

An acetylcholine receptor subunit epsilon that is encoded in the genome of human.


monoatomic cation transmembrane transporter activity

Enables the transfer of cation from one side of a membrane to the other.


REL_HUMAN Proto-oncogene c-Rel (sprot)

A proto-oncogene c-Rel that is encoded in the genome of human.


MUC24_HUMAN Sialomucin core protein 24 (sprot)

A sialomucin core protein 24 that is encoded in the genome of human.


RON_HUMAN Macrophage-stimulating protein receptor (sprot)

A macrophage-stimulating protein receptor that is encoded in the genome of human.


1433F_HUMAN 14-3-3 protein eta (sprot)

A 14-3-3 protein eta that is encoded in the genome of human.


glucocorticoid catabolic process

The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.


PLP2_HUMAN Proteolipid protein 2 (sprot)

A proteolipid protein 2 that is encoded in the genome of human.


CSTF1_HUMAN Cleavage stimulation factor subunit 1 (sprot)

A cleavage stimulation factor subunit 1 that is encoded in the genome of human.


SRY_HUMAN Sex-determining region Y protein (sprot)

A sex-determining region Y protein that is encoded in the genome of human.


ICA69_HUMAN Islet cell autoantigen 1 (sprot)

An islet cell autoantigen 1 that is encoded in the genome of human.


UBE3A_HUMAN Ubiquitin-protein ligase E3A (sprot)

A ubiquitin-protein ligase E3A that is encoded in the genome of human.


sperm entry

An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur.


positive regulation of Golgi lumen acidification

Any process that activates or increases the frequency, rate or extent of Golgi lumen acidification.


DYN1_HUMAN Dynamin-1 (sprot)

A dynamin-1 that is encoded in the genome of human.


synaptic vesicle budding from presynaptic endocytic zone membrane

Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle.


clathrin coat assembly involved in endocytosis

The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation.


vesicle scission

The membrane scission process that is the final step in the formation of a vesicle, leading to separation from its parent membrane. Vesicle scission involves the constriction of a neck-forming protein complex, consisting e.g. of dynamin, around the budded membrane, leading to vesicle closure during its separation from the parent membrane.


MAD1_HUMAN Max dimerization protein 1 (sprot)

A max dimerization protein 1 that is encoded in the genome of human.


PTN12_HUMAN Tyrosine-protein phosphatase non-receptor type 12 (sprot)

A tyrosine-protein phosphatase non-receptor type 12 that is encoded in the genome of human.


negative regulation of ERBB signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway.


EGR4_HUMAN Early growth response protein 4 (sprot)

An early growth response protein 4 that is encoded in the genome of human.


LEG10_HUMAN Galectin-10 (sprot)

A galectin-10 that is encoded in the genome of human.


DCE2_HUMAN Glutamate decarboxylase 2 (sprot)

A glutamate decarboxylase 2 that is encoded in the genome of human.


FAK1_HUMAN Focal adhesion kinase 1 (sprot)

A focal adhesion kinase 1 that is encoded in the genome of human.


LIPS_HUMAN Hormone-sensitive lipase (sprot)

A hormone-sensitive lipase that is encoded in the genome of human.


Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid.


Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid.


ZNF91_HUMAN Zinc finger protein 91 (sprot)

A zinc finger protein 91 that is encoded in the genome of human.


KPCZ_HUMAN Protein kinase C zeta type (sprot)

A protein kinase C zeta type that is encoded in the genome of human.


ZBT16_HUMAN Zinc finger and BTB domain-containing protein 16 (sprot)

A zinc finger and BTB domain-containing protein 16 that is encoded in the genome of human.


SRS11_HUMAN Serine/arginine-rich splicing factor 11 (sprot)

A serine/arginine-rich splicing factor 11 that is encoded in the genome of human.


NMDZ1_HUMAN Glutamate receptor ionotropic, NMDA 1 (sprot)

A glutamate receptor ionotropic, NMDA 1 that is encoded in the genome of human.


propylene metabolic process

The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals.


response to glycine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus.


EF1A2_HUMAN Elongation factor 1-alpha 2 (sprot)

An elongation factor 1-alpha 2 that is encoded in the genome of human.


KPCD_HUMAN Protein kinase C delta type (sprot)

A protein kinase C delta type that is encoded in the genome of human.


positive regulation of phospholipid scramblase activity

Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity.


regulation of ceramide biosynthetic process

Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process.


positive regulation of glucosylceramide catabolic process

Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process.


positive regulation of sphingomyelin catabolic process

Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process.


CALD1_HUMAN Caldesmon (sprot)

A caldesmon that is encoded in the genome of human.


COEA1_HUMAN Collagen alpha-1(XIV) chain (sprot)

A collagen alpha-1(XIV) chain that is encoded in the genome of human.


regulation of cell growth involved in cardiac muscle cell development

Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.


collagen type XIV trimer

A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures.


RN5A_HUMAN 2-5A-dependent ribonuclease (sprot)

A 2-5A-dependent ribonuclease that is encoded in the genome of human.


ACHB3_HUMAN Neuronal acetylcholine receptor subunit beta-3 (sprot)

A neuronal acetylcholine receptor subunit beta-3 that is encoded in the genome of human.


DUS2_HUMAN Dual specificity protein phosphatase 2 (sprot)

A dual specificity protein phosphatase 2 that is encoded in the genome of human.


HME1_HUMAN Homeobox protein engrailed-1 (sprot)

A homeobox protein engrailed-1 that is encoded in the genome of human.


FOLC_HUMAN Folylpolyglutamate synthase, mitochondrial (sprot)

A folylpolyglutamate synthase, mitochondrial that is encoded in the genome of human.


Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).


The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.


VMAT2_HUMAN Synaptic vesicular amine transporter (sprot)

A synaptic vesicular amine transporter that is encoded in the genome of human.


serotonin secretion by mast cell

The regulated release of serotonin by a mast cell or group of mast cells.


sequestering of neurotransmitter

The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system.


neurotransmitter loading into synaptic vesicle

The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps.


somato-dendritic dopamine secretion

The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron.


STP2_HUMAN Nuclear transition protein 2 (sprot)

A nuclear transition protein 2 that is encoded in the genome of human.


ZP2_HUMAN Zona pellucida sperm-binding protein 2 (sprot)

A zona pellucida sperm-binding protein 2 that is encoded in the genome of human.


MBTD1_HUMAN MBT domain-containing protein 1 (sprot)

An MBT domain-containing protein 1 that is encoded in the genome of human.


NuA4 histone acetyltransferase complex binding

Binding to a NuA4 histone acetyltransferase complex.


EMAL5_HUMAN Echinoderm microtubule-associated protein-like 5 (sprot)

An echinoderm microtubule-associated protein-like 5 that is encoded in the genome of human.


CTSL2_HUMAN CTD small phosphatase-like protein 2 (sprot)

A CTD small phosphatase-like protein 2 that is encoded in the genome of human.


DEUP1_HUMAN Deuterosome assembly protein 1 (sprot)

A deuterosome assembly protein 1 that is encoded in the genome of human.


FHI1A_HUMAN FHF complex subunit HOOK-interacting protein 1A (sprot)

An FHF complex subunit HOOK interacting protein 1A that is encoded in the genome of human.


protein localization to perinuclear region of cytoplasm

A process in which a protein is transported to, or maintained in, a location within the perinuclear region of the cytoplasm.


ITIH3_HUMAN Inter-alpha-trypsin inhibitor heavy chain H3 (sprot)

An inter-alpha-trypsin inhibitor heavy chain H3 that is encoded in the genome of human.