HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1 (sprot)

A probable E3 ubiquitin-protein ligase HERC1 that is encoded in the genome of human.


AAAT_HUMAN Neutral amino acid transporter B(0) (sprot)

A neutral amino acid transporter B(0) that is encoded in the genome of human.


ligand-gated channel activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


glutamine secretion

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The controlled release of glutamine by a cell.


L-glutamine import across plasma membrane

The directed movement of L-glutamine from outside of a cell, across the plasma membrane and into the cytosol.


MK11_HUMAN Mitogen-activated protein kinase 11 (sprot)

A mitogen-activated protein kinase 11 that is encoded in the genome of human.


GPR19_HUMAN Probable G-protein coupled receptor 19 (sprot)

A probable G-protein coupled receptor 19 that is encoded in the genome of human.


NPY5R_HUMAN Neuropeptide Y receptor type 5 (sprot)

A neuropeptide Y receptor type 5 that is encoded in the genome of human.


CD226_HUMAN CD226 antigen (sprot)

A CD226 molecule that is encoded in the genome of human.


positive regulation of mast cell activation

Any process that activates or increases the frequency, rate, or extent of mast cell activation.


EFNB3_HUMAN Ephrin-B3 (sprot)

An ephrin-B3 that is encoded in the genome of human.


axon choice point recognition

The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth.


positive regulation of presynapse assembly

Any process that activates or increases the frequency, rate or extent of presynapse assembly.


RAB30_HUMAN Ras-related protein Rab-30 (sprot)

A Ras-related protein Rab-30 that is encoded in the genome of human.


SPEG_HUMAN Striated muscle preferentially expressed protein kinase (sprot)

A striated muscle preferentially expressed protein kinase that is encoded in the genome of human.


MLF2_HUMAN Myeloid leukemia factor 2 (sprot)

A myeloid leukemia factor 2 that is encoded in the genome of human.


ZKSC8_HUMAN Zinc finger protein with KRAB and SCAN domains 8 (sprot)

A zinc finger protein with KRAB and SCAN domains 8 that is encoded in the genome of human.


MPPD2_HUMAN Metallophosphoesterase MPPED2 (sprot)

A metallophosphoesterase MPPED2 that is encoded in the genome of human.


GMP binding

Binding to GMP, guanosine monophosphate.


CH3L2_HUMAN Chitinase-3-like protein 2 (sprot)

A chitinase-3-like protein 2 that is encoded in the genome of human.


NDF2_HUMAN Neurogenic differentiation factor 2 (sprot)

A neurogenic differentiation factor 2 that is encoded in the genome of human.


TOM34_HUMAN Mitochondrial import receptor subunit TOM34 (sprot)

A mitochondrial import receptor subunit TOM34 that is encoded in the genome of human.


NCOA1_HUMAN Nuclear receptor coactivator 1 (sprot)

A nuclear receptor coactivator 1 that is encoded in the genome of human.


positive regulation of transcription from RNA polymerase II promoter by galactose

Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.


SMAD2_HUMAN Mothers against decapentaplegic homolog 2 (sprot)

A smad2 that is encoded in the genome of human.


regulation of binding

Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.


SMAD1_HUMAN Mothers against decapentaplegic homolog 1 (sprot)

A smad1 that is encoded in the genome of human.


mesodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the mesoderm.


homomeric SMAD protein complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A protein complex composed of a single type of SMAD family proteins. In the absence of Smad4, phosphorylation of R-SMADs results in their homotrimerization. However, these complexes do not appear to import into the nucleus and are assumed to be transcriptionally inactive.


MSMO1_HUMAN Methylsterol monooxygenase 1 (sprot)

A methylsterol monooxygenase 1 that is encoded in the genome of human.


C-4 methylsterol oxidase activity

Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O.


ITSN1_HUMAN Intersectin-1 (sprot)

An intersectin-1 that is encoded in the genome of human.


TBCE_HUMAN Tubulin-specific chaperone E (sprot)

A tubulin-specific chaperone E that is encoded in the genome of human.


TBCC_HUMAN Tubulin-specific chaperone C (sprot)

A tubulin-specific chaperone C that is encoded in the genome of human.


NPTX1_HUMAN Neuronal pentraxin-1 (sprot)

A neuronal pentraxin-1 that is encoded in the genome of human.


UB2V2_HUMAN Ubiquitin-conjugating enzyme E2 variant 2 (sprot)

A ubiquitin-conjugating enzyme E2 variant 2 that is encoded in the genome of human.


error-free postreplication DNA repair

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate.


ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2 (sprot)

A neuronal acetylcholine receptor subunit alpha-2 that is encoded in the genome of human.


modulation of inhibitory postsynaptic potential

Any process that modulates the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.


neuron projection cytoplasm

All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection.


ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6 (sprot)

A neuronal acetylcholine receptor subunit alpha-6 that is encoded in the genome of human.


CYTM_HUMAN Cystatin-M (sprot)

A cystatin-M that is encoded in the genome of human.


STK11_HUMAN Serine/threonine-protein kinase STK11 (sprot)

A serine/threonine-protein kinase STK11 that is encoded in the genome of human.


dendrite extension

Long distance growth of a single dendrite involved in cellular development.


positive regulation of vesicle transport along microtubule

Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule.


A protein-containing complex located intracellularly.


STXB2_HUMAN Syntaxin-binding protein 2 (sprot)

A syntaxin-binding protein 2 that is encoded in the genome of human.


leukocyte mediated cytotoxicity

The directed killing of a target cell by a leukocyte.


CC85B_HUMAN Coiled-coil domain-containing protein 85B (sprot)

A coiled-coil domain-containing protein 85B that is encoded in the genome of human.


GRK1_HUMAN Rhodopsin kinase GRK1 (sprot)

A rhodopsin kinase GRK1 that is encoded in the genome of human.


VAMP3_HUMAN Vesicle-associated membrane protein 3 (sprot)

A vesicle-associated membrane protein 3 that is encoded in the genome of human.


negative regulation of secretion by cell

Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.


KCNJ8_HUMAN ATP-sensitive inward rectifier potassium channel 8 (sprot)

An ATP-sensitive inward rectifier potassium channel 8 that is encoded in the genome of human.


NLRP3 inflammasome complex assembly

The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell.


atrioventricular node cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node.


NEDD8_HUMAN NEDD8 (sprot)

A NEDD8 protein that is encoded in the genome of human.


ADIRF_HUMAN Adipogenesis regulatory factor (sprot)

An adipogenesis regulatory factor that is encoded in the genome of human.


ADIPO_HUMAN Adiponectin (sprot)

An adiponectin that is encoded in the genome of human.


positive regulation of myeloid cell apoptotic process

Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.


positive regulation of fatty acid metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.


detection of oxidative stress

The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal.


negative regulation of intracellular protein transport

Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.


positive regulation of lipid transporter activity

Any process that increases the frequency, rate, or extent of lipid transporter activity.


positive regulation of metanephric podocyte development

Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development.


positive regulation of renal albumin absorption

Any process that activates or increases the frequency, rate or extent of renal albumin absorption.


negative regulation of metanephric mesenchymal cell migration

Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration.


UT2_HUMAN Urea transporter 2 (sprot)

A urea transporter 2 that is encoded in the genome of human.


USF2_HUMAN Upstream stimulatory factor 2 (sprot)

An upstream stimulatory factor 2 that is encoded in the genome of human.


SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (sprot)

A sodium channel protein type 9 subunit alpha that is encoded in the genome of human.


CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E (sprot)

A voltage-dependent R-type calcium channel subunit alpha-1E that is encoded in the genome of human.


EREP1_HUMAN Endosomal transmembrane epsin interactor 1 (sprot)

An endosomal transmembrane epsin interactor 1 that is encoded in the genome of human.


negative adaptation of signaling pathway

The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.


VAS1_HUMAN V-type proton ATPase subunit S1 (sprot)

A V-type proton ATPase subunit S1 that is encoded in the genome of human.


VPS72_HUMAN Vacuolar protein sorting-associated protein 72 homolog (sprot)

A vacuolar protein sorting-associated protein 72 that is encoded in the genome of human.


ATP-dependent H2AZ histone chaperone activity

A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite.


RB11B_HUMAN Ras-related protein Rab-11B (sprot)

A Ras-related protein Rab-11B that is encoded in the genome of human.


EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (sprot)

A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of human.


histone H3K27 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein.


histone H3K27 trimethyltransferase activity

Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3.


regulation of gliogenesis

Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.


hepatocyte homeostasis

Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules.


regulation of kidney development

Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


ZFHX3_HUMAN Zinc finger homeobox protein 3 (sprot)

A zinc finger homeobox protein 3 that is encoded in the genome of human.


ZIC1_HUMAN Zinc finger protein ZIC 1 (sprot)

A zinc finger protein ZIC 1 that is encoded in the genome of human.


maintenance of cell number

Any process by which the numbers of cells of a particular type or in a tissue are maintained.


ZBTB6_HUMAN Zinc finger and BTB domain-containing protein 6 (sprot)

A zinc finger and BTB domain-containing protein 6 that is encoded in the genome of human.


ZN141_HUMAN Zinc finger protein 141 (sprot)

A zinc finger protein 141 that is encoded in the genome of human.


ZNF77_HUMAN Zinc finger protein 77 (sprot)

A zinc finger protein 77 that is encoded in the genome of human.


ZNF79_HUMAN Zinc finger protein 79 (sprot)

A zinc finger protein 79 that is encoded in the genome of human.


ZNF67_HUMAN Putative zinc finger protein 726P1 (sprot)


ZYX_HUMAN Zyxin (sprot)

A zyxin that is encoded in the genome of human.


ZN124_HUMAN Zinc finger protein 124 (sprot)

A zinc finger protein 124 that is encoded in the genome of human.


MCHL1_HUMAN Putative pro-MCH-like protein 1 (sprot)

A putative pro-MCH-like protein 1 that is encoded in the genome of human.


HSPB2_HUMAN Heat shock protein beta-2 (sprot)

A heat shock protein beta-2 that is encoded in the genome of human.


GRIK4_HUMAN Glutamate receptor ionotropic, kainate 4 (sprot)

A glutamate receptor ionotropic, kainate 4 that is encoded in the genome of human.


ETFD_HUMAN Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (sprot)

An electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial that is encoded in the genome of human.


Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein].


SYUB_HUMAN Beta-synuclein (sprot)

A beta-synuclein that is encoded in the genome of human.


SEPT7_HUMAN Septin-7 (sprot)

A septin-7 that is encoded in the genome of human.


ADRM1_HUMAN Proteasomal ubiquitin receptor ADRM1 (sprot)

A proteasomal ubiquitin receptor ADRM1 that is encoded in the genome of human.


CCDC6_HUMAN Coiled-coil domain-containing protein 6 (sprot)

A coiled-coil domain-containing protein 6 that is encoded in the genome of human.


ENOX2_HUMAN Ecto-NOX disulfide-thiol exchanger 2 (sprot)

An ecto-NOX disulfide-thiol exchanger 2 that is encoded in the genome of human.


ultradian rhythm

The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours.


UAP1_HUMAN UDP-N-acetylhexosamine pyrophosphorylase (sprot)

A UDP-N-acetylhexosamine pyrophosphorylase that is encoded in the genome of human.


Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine.


NF2L2_HUMAN Nuclear factor erythroid 2-related factor 2 (sprot)

A nuclear factor erythroid 2-related factor 2 that is encoded in the genome of human.


aflatoxin catabolic process

The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.


positive regulation of glutathione biosynthetic process

Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process.


E2F4_HUMAN Transcription factor E2F4 (sprot)

A transcription factor E2F4 that is encoded in the genome of human.


IBP7_HUMAN Insulin-like growth factor-binding protein 7 (sprot)

An insulin-like growth factor-binding protein 7 that is encoded in the genome of human.


CNGA2_HUMAN Cyclic nucleotide-gated olfactory channel (sprot)

A cyclic nucleotide-gated olfactory channel that is encoded in the genome of human.


CNGA3_HUMAN Cyclic nucleotide-gated cation channel alpha-3 (sprot)

A cyclic nucleotide-gated cation channel alpha-3 that is encoded in the genome of human.


NTRK3_HUMAN NT-3 growth factor receptor (sprot)

An NT-3 growth factor receptor that is encoded in the genome of human.


KCA10_HUMAN Potassium voltage-gated channel subfamily A member 10 (sprot)

A voltage-gated potassium channel subunit KCNA10 that is encoded in the genome of human.


intracellular cyclic nucleotide activated monoatomic cation channel activity

Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts.


PDCD2_HUMAN Programmed cell death protein 2 (sprot)

A programmed cell death protein 2 that is encoded in the genome of human.


S15A2_HUMAN Solute carrier family 15 member 2 (sprot)

A solute carrier family 15 member 2 that is encoded in the genome of human.


peptidoglycan transport

The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


dipeptide transport

The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


AINX_HUMAN Alpha-internexin (sprot)

An alpha-internexin that is encoded in the genome of human.


LAMA4_HUMAN Laminin subunit alpha-4 (sprot)

A laminin subunit alpha-4 that is encoded in the genome of human.


PROL4_HUMAN Proline-rich protein 4 (sprot)

A proline-rich protein 4 that is encoded in the genome of human.


SSX1_HUMAN Protein SSX1 (sprot)

A protein SSX1 that is encoded in the genome of human.


SSX2_HUMAN Protein SSX2 (sprot)

A protein SSX2 that is encoded in the genome of human.


EXT1_HUMAN Exostosin-1 (sprot)

An exostosin-1 that is encoded in the genome of human.


Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP.


heparan sulfate N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate.


Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.


polysaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


hypersensitivity

An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.


heart field specification

The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop.


chondroitin sulfate metabolic process

The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.


lymphocyte adhesion to endothelial cell of high endothelial venule

The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream.


fluid transport

The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


smoothened signaling pathway involved in lung development

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development.


sweat gland development

The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation.


perichondral bone morphogenesis

The process in which bones are generated and organized as a result of the conversion of initial connective tissue surrounding cartilage into bone.


response to heparin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.


mesenchymal cell differentiation involved in bone development

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state.


PSMD5_HUMAN 26S proteasome non-ATPase regulatory subunit 5 (sprot)

A 26S proteasome non-ATPase regulatory subunit 5 that is encoded in the genome of human.


GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 (sprot)

A gamma-aminobutyric acid receptor subunit alpha-6 that is encoded in the genome of human.


cerebellar Golgi cell to granule cell synapse

A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell.


TENXA_HUMAN Putative tenascin-XA (sprot)


GRIK5_HUMAN Glutamate receptor ionotropic, kainate 5 (sprot)

A glutamate receptor ionotropic, kainate 5 that is encoded in the genome of human.


PKN1_HUMAN Serine/threonine-protein kinase N1 (sprot)

A serine/threonine-protein kinase N1 that is encoded in the genome of human.


PKN2_HUMAN Serine/threonine-protein kinase N2 (sprot)

A serine/threonine-protein kinase N2 that is encoded in the genome of human.


TAF12_HUMAN Transcription initiation factor TFIID subunit 12 (sprot)

A transcription initiation factor TFIID subunit 12 that is encoded in the genome of human.


ASIC2_HUMAN Acid-sensing ion channel 2 (sprot)

An acid-sensing ion channel 2 that is encoded in the genome of human.


regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback

The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control.


NNAT_HUMAN Neuronatin (sprot)

A neuronatin that is encoded in the genome of human.


RPE65_HUMAN Retinoid isomerohydrolase (sprot)

A retinal pigment epithelium-specific 65 kDa protein that is encoded in the genome of human.


all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity

Catalysis of the reaction: H2O + all-trans-retinyl palmitate = 11-cis-retinol + H+ + palmitate.


all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity

Catalysis of the reaction: H2O + all-trans-retinyl ester = 11-cis-retinol + fatty acid.


zeaxanthin biosynthetic process

The chemical reactions and pathways resulting in the formation of zeaxanthin.


BATF_HUMAN Basic leucine zipper transcriptional factor ATF-like (sprot)

A basic leucine zipper transcriptional factor ATF-like that is encoded in the genome of human.


CRY1_HUMAN Cryptochrome-1 (sprot)

A cryptochrome-1 that is encoded in the genome of human.


blue light photoreceptor activity

The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation.


blue light signaling pathway

The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm.


negative regulation of glucocorticoid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion.


CSRP2_HUMAN Cysteine and glycine-rich protein 2 (sprot)

A cysteine and glycine-rich protein 2 that is encoded in the genome of human.


DDB1_HUMAN DNA damage-binding protein 1 (sprot)

A DNA damage-binding protein 1 that is encoded in the genome of human.


SNPC1_HUMAN snRNA-activating protein complex subunit 1 (sprot)

An snRNA-activating protein complex subunit 1 that is encoded in the genome of human.


HLF_HUMAN Hepatic leukemia factor (sprot)

A hepatic leukemia factor that is encoded in the genome of human.


2A5E_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (sprot)

A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform that is encoded in the genome of human.


GP162_HUMAN Probable G-protein coupled receptor 162 (sprot)

A probable G-protein coupled receptor 162 that is encoded in the genome of human.


MK14_HUMAN Mitogen-activated protein kinase 14 (sprot)

A mitogen-activated protein kinase 14 that is encoded in the genome of human.


RM23_HUMAN Large ribosomal subunit protein uL23m (sprot)

A 39S ribosomal protein L23, mitochondrial that is encoded in the genome of human.


CDC37_HUMAN Hsp90 co-chaperone Cdc37 (sprot)

An Hsp90 co-chaperone Cdc37 that is encoded in the genome of human.


B2LA1_HUMAN Bcl-2-related protein A1 (sprot)

A Bcl-2-related protein A1 that is encoded in the genome of human.


PCSK7_HUMAN Proprotein convertase subtilisin/kexin type 7 (sprot)

A proprotein convertase subtilisin/kexin type 7 that is encoded in the genome of human.


IL17_HUMAN Interleukin-17A (sprot)

An interleukin-17A that is encoded in the genome of human.


positive regulation of interleukin-16 production

Any process that activates or increases the frequency, rate, or extent of interleukin-16 production.


positive regulation of antimicrobial peptide production

Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.


granulocyte migration

The movement of a granulocyte within or between different tissues and organs of the body.


LY6E_HUMAN Lymphocyte antigen 6E (sprot)

A lymphocyte antigen 6E that is encoded in the genome of human.


DPYL2_HUMAN Dihydropyrimidinase-related protein 2 (sprot)

A dihydropyrimidinase-related protein 2 that is encoded in the genome of human.


PSG3_HUMAN Pregnancy-specific beta-1-glycoprotein 3 (sprot)

A pregnancy-specific beta-1-glycoprotein 3 that is encoded in the genome of human.


KCMB1_HUMAN Calcium-activated potassium channel subunit beta-1 (sprot)

A calcium-activated potassium channel subunit beta-1 that is encoded in the genome of human.


TAL2_HUMAN T-cell acute lymphocytic leukemia protein 2 (sprot)

A T-cell acute lymphocytic leukemia protein 2 that is encoded in the genome of human.


U1SBP_HUMAN U11/U12 small nuclear ribonucleoprotein 35 kDa protein (sprot)

A U11/U12 small nuclear ribonucleoprotein 35 kDa protein that is encoded in the genome of human.


SYPL1_HUMAN Synaptophysin-like protein 1 (sprot)

A synaptophysin-like protein 1 that is encoded in the genome of human.


KCC4_HUMAN Calcium/calmodulin-dependent protein kinase type IV (sprot)

A calcium/calmodulin-dependent protein kinase type IV that is encoded in the genome of human.


CART_HUMAN Cocaine- and amphetamine-regulated transcript protein (sprot)

A cocaine- and amphetamine-regulated transcript protein that is encoded in the genome of human.


positive regulation of epinephrine secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine.


somatostatin secretion

The regulated release of somatostatin from secretory granules in the D cells of the pancreas.


ACKR1_HUMAN Atypical chemokine receptor 1 (sprot)

An atypical chemokine receptor 1 that is encoded in the genome of human.


VACHT_HUMAN Vesicular acetylcholine transporter (sprot)

A vesicular acetylcholine transporter that is encoded in the genome of human.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out).


acetylcholine uptake

The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.


RBBP7_HUMAN Histone-binding protein RBBP7 (sprot)

A histone-binding protein RBBP7 that is encoded in the genome of human.


C3AR_HUMAN C3a anaphylatoxin chemotactic receptor (sprot)

A C3a anaphylatoxin chemotactic receptor that is encoded in the genome of human.


complement component C3a receptor activity

Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 (sprot)

A mitogen-activated protein kinase kinase kinase 11 that is encoded in the genome of human.


SGCB_HUMAN Beta-sarcoglycan (sprot)

A beta-sarcoglycan that is encoded in the genome of human.


SGCA_HUMAN Alpha-sarcoglycan (sprot)

An alpha-sarcoglycan that is encoded in the genome of human.


ZNF74_HUMAN Zinc finger protein 74 (sprot)

A zinc finger protein 74 that is encoded in the genome of human.


CCNG2_HUMAN Cyclin-G2 (sprot)

A cyclin-G2 that is encoded in the genome of human.


TAF9_HUMAN Transcription initiation factor TFIID subunit 9 (sprot)

A transcription initiation factor TFIID subunit 9 that is encoded in the genome of human.


FRDA_HUMAN Frataxin, mitochondrial (sprot)

A frataxin, mitochondrial that is encoded in the genome of human.


[4Fe-4S] cluster assembly

The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster.


regulation of ferrochelatase activity

Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+.


iron incorporation into metallo-sulfur cluster

The incorporation of iron into a metallo-sulfur cluster.


positive regulation of lyase activity

Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


positive regulation of succinate dehydrogenase activity

Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity.


positive regulation of aconitate hydratase activity

Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.


mitochondrial iron-sulfur cluster assembly complex

A protein complex consisting of frataxin, cysteine desulfurase, an accessory protein and a Fe-S scaffold protein. In human these genes correspond to FXN, NFS1, ISD11 and ISCU respectively. This complex assembles Fe-S clusters onto the scaffolding protein using the substrates ferrous iron, electrons, and sulfur from l-cysteine.


L-cysteine desulfurase complex

A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer.


ZN239_HUMAN Zinc finger protein 239 (sprot)

A zinc finger protein 239 that is encoded in the genome of human.


CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (sprot)

A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human.


calcitonin receptor activity

Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


cellular response to sucrose stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.


LPAL2_HUMAN Putative apolipoprotein(a)-like protein 2 (sprot)

A putative apolipoprotein(a)-like protein 2 that is encoded in the genome of human.


ECM1_HUMAN Extracellular matrix protein 1 (sprot)

An extracellular matrix protein 1 that is encoded in the genome of human.


regulation of type 2 immune response

Any process that modulates the frequency, rate, or extent of a type 2 immune response.


BAK_HUMAN Bcl-2 homologous antagonist/killer (sprot)

A Bcl-2 homologous antagonist/killer that is encoded in the genome of human.


BH domain binding

Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains.


response to fungus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.


NREP_HUMAN Neuronal regeneration-related protein (sprot)

A neuronal regeneration-related protein that is encoded in the genome of human.


SNAT_HUMAN Serotonin N-acetyltransferase (sprot)

A serotonin N-acetyltransferase that is encoded in the genome of human.


Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine.


NKG7_HUMAN Protein NKG7 (sprot)

A protein NKG7 that is encoded in the genome of human.


natural killer cell mediated cytotoxicity directed against tumor cell target

The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.


CD4-positive, alpha-beta T cell activation

The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


CTF1_HUMAN Cardiotrophin-1 (sprot)

A cardiotrophin-1 that is encoded in the genome of human.


NTRK2_HUMAN BDNF/NT-3 growth factors receptor (sprot)

A BDNF/NT-3 growth factors receptor that is encoded in the genome of human.


brain-derived neurotrophic factor receptor activity

Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.


NFE2_HUMAN Transcription factor NF-E2 45 kDa subunit (sprot)

A transcription factor NF-E2 45 kDa subunit that is encoded in the genome of human.


STX1A_HUMAN Syntaxin-1A (sprot)

A syntaxin-1A that is encoded in the genome of human.


OCLN_HUMAN Occludin (sprot)

An occludin that is encoded in the genome of human.


MEA1_HUMAN Male-enhanced antigen 1 (sprot)

A male-enhanced antigen 1 that is encoded in the genome of human.


CCL14_HUMAN C-C motif chemokine 14 (sprot)

A C-C motif chemokine 14 that is encoded in the genome of human.


SRSF7_HUMAN Serine/arginine-rich splicing factor 7 (sprot)

A serine/arginine-rich splicing factor 7 that is encoded in the genome of human.


CPSF6_HUMAN Cleavage and polyadenylation specificity factor subunit 6 (sprot)

A cleavage and polyadenylation specificity factor subunit 6 that is encoded in the genome of human.


exon-exon junction complex binding

Binding to an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.


OBF1_HUMAN POU domain class 2-associating factor 1 (sprot)

A POU domain class 2-associating factor 1 that is encoded in the genome of human.


TAZ_HUMAN Tafazzin (sprot)

A tafazzin that is encoded in the genome of human.


spermatocyte division

The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids.


positive regulation of cardiolipin metabolic process

Any process that activates or increases the frequency, rate or extent of cardiolipin metabolic process.


SMN_HUMAN Survival motor neuron protein (sprot)

A survival motor neuron protein that is encoded in the genome of human.


DREB_HUMAN Drebrin (sprot)

A drebrin that is encoded in the genome of human.


MAPK3_HUMAN MAP kinase-activated protein kinase 3 (sprot)

A MAP kinase-activated protein kinase 3 that is encoded in the genome of human.


PTGIS_HUMAN Prostacyclin synthase (sprot)

A prostacyclin synthase that is encoded in the genome of human.


prostaglandin-I synthase activity

Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).


NFIL3_HUMAN Nuclear factor interleukin-3-regulated protein (sprot)

A nuclear factor interleukin-3-regulated protein that is encoded in the genome of human.


TBR1_HUMAN T-box brain protein 1 (sprot)

A T-box brain protein 1 that is encoded in the genome of human.


specification of animal organ identity

The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


PRSS8_HUMAN Prostasin (sprot)

A prostasin that is encoded in the genome of human.


MOG_HUMAN Myelin-oligodendrocyte glycoprotein (sprot)

A myelin-oligodendrocyte glycoprotein that is encoded in the genome of human.


PDK4_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (sprot)

A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial that is encoded in the genome of human.


MAR1_HUMAN Melanoma antigen recognized by T-cells 1 (sprot)

A melanoma antigen recognized by T-cells 1 that is encoded in the genome of human.


NRF1_HUMAN Nuclear respiratory factor 1 (sprot)

A nuclear respiratory factor 1 that is encoded in the genome of human.


FSCN1_HUMAN Fascin (sprot)

A fascin that is encoded in the genome of human.


MK06_HUMAN Mitogen-activated protein kinase 6 (sprot)

A mitogen-activated protein kinase 6 that is encoded in the genome of human.


septin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes.


GUC2B_HUMAN Guanylate cyclase activator 2B (sprot)

A guanylate cyclase activator 2B that is encoded in the genome of human.


CCL15_HUMAN C-C motif chemokine 15 (sprot)

A C-C motif chemokine 15 that is encoded in the genome of human.


HIF1A_HUMAN Hypoxia-inducible factor 1-alpha (sprot)

A hypoxia-inducible factor 1-alpha that is encoded in the genome of human.


IF16_HUMAN Gamma-interferon-inducible protein 16 (sprot)

A gamma-interferon-inducible protein 16 that is encoded in the genome of human.


CDKN3_HUMAN Cyclin-dependent kinase inhibitor 3 (sprot)

A cyclin-dependent kinase inhibitor 3 that is encoded in the genome of human.


ZSC26_HUMAN Zinc finger and SCAN domain-containing protein 26 (sprot)

A zinc finger and SCAN domain-containing protein 26 that is encoded in the genome of human.


AMHR2_HUMAN Anti-Muellerian hormone type-2 receptor (sprot)

An anti-Muellerian hormone type-2 receptor that is encoded in the genome of human.


anti-Mullerian hormone receptor activity

Combining with anti-Mullerian hormone to initiate a change in cell activity.


MIA_HUMAN Melanoma-derived growth regulatory protein (sprot)

A melanoma-derived growth regulatory protein that is encoded in the genome of human.


FOXD1_HUMAN Forkhead box protein D1 (sprot)

A forkhead box protein D1 that is encoded in the genome of human.


dichotomous subdivision of terminal units involved in ureteric bud branching

The process in which a ureteric bud bifurcates at its end.


nephrogenic mesenchyme development

The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron.


metanephric nephron development

The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.


metanephric capsule development

The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage.


metanephric capsule specification

The regionalization process in which the identity of the metanephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


CP1B1_HUMAN Cytochrome P450 1B1 (sprot)

A cytochrome P450 1B1 that is encoded in the genome of human.


benzene-containing compound metabolic process

The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives.


membrane lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane.


response to indole-3-methanol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus.


DUS5_HUMAN Dual specificity protein phosphatase 5 (sprot)

A dual specificity protein phosphatase 5 that is encoded in the genome of human.


H31T_HUMAN Histone H3.1t (sprot)

A histone H3.1t that is encoded in the genome of human.


CP2AD_HUMAN Cytochrome P450 2A13 (sprot)

A cytochrome P450 2A that is a translation product of the CYP2A13 gene in human.


DECR_HUMAN 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (sprot)

A 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial that is encoded in the genome of human.


2,4-dienoyl-CoA reductase (NADPH) activity

Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.


MA2A1_HUMAN Alpha-mannosidase 2 (sprot)

An alpha-mannosidase 2 that is encoded in the genome of human.


alpha-mannosidase activity

Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.


NDUA5_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 that is encoded in the genome of human.


KYNU_HUMAN Kynureninase (sprot)

A kynureninase that is encoded in the genome of human.


kynureninase activity

Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine.


3-hydroxykynureninase activity

Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.


L-kynurenine catabolic process

The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine).


AT2B3_HUMAN Plasma membrane calcium-transporting ATPase 3 (sprot)

A plasma membrane calcium-transporting ATPase 3 that is encoded in the genome of human.


P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration

A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration.


parallel fiber

A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium.


CEGT_HUMAN Ceramide glucosyltransferase (sprot)

A ceramide glucosyltransferase that is encoded in the genome of human.


ceramide glucosyltransferase activity

Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.


Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine.


glucosylceramide biosynthetic process

The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.


CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (sprot)

An ATP-dependent Clp protease proteolytic subunit, mitochondrial that is encoded in the genome of human.


DGKD_HUMAN Diacylglycerol kinase delta (sprot)

A diacylglycerol kinase delta that is encoded in the genome of human.


THTR_HUMAN Thiosulfate sulfurtransferase (sprot)

A thiosulfate sulfurtransferase that is encoded in the genome of human.


thiosulfate sulfurtransferase activity

Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate.


rRNA import into mitochondrion

The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol into the mitochondrial matrix.


rRNA transport

The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


UBE2S_HUMAN Ubiquitin-conjugating enzyme E2 S (sprot)

A ubiquitin-conjugating enzyme E2 S that is encoded in the genome of human.


QPCT_HUMAN Glutaminyl-peptide cyclotransferase (sprot)

A glutaminyl-peptide cyclotransferase that is encoded in the genome of human.


Catalysis of the reaction: N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4+.


peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase

The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase.


GSTA3_HUMAN Glutathione S-transferase A3 (sprot)

A glutathione S-transferase A3 that is encoded in the genome of human.


KAT1_HUMAN Kynurenine--oxoglutarate transaminase 1 (sprot)

A kynurenine--oxoglutarate transaminase 1 that is encoded in the genome of human.


Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine.


Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate.


KGUA_HUMAN Guanylate kinase (sprot)

A guanylate kinase that is encoded in the genome of human.


dGDP biosynthetic process

The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate).


GLO2_HUMAN Hydroxyacylglutathione hydrolase, mitochondrial (sprot)

A hydroxyacylglutathione hydrolase that is encoded in the genome of human.


Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.


methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.


H2A2C_HUMAN Histone H2A type 2-C (sprot)

A histone H2A type 2-C that is encoded in the genome of human.


H2B2E_HUMAN Histone H2B type 2-E (sprot)

A histone H2B type 2-E that is encoded in the genome of human.


LAMA3_HUMAN Laminin subunit alpha-3 (sprot)

A laminin subunit alpha-3 that is encoded in the genome of human.


CAH9_HUMAN Carbonic anhydrase 9 (sprot)

A carbonic anhydrase 9 that is encoded in the genome of human.


NDUA9_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial that is encoded in the genome of human.


MAON_HUMAN NADP-dependent malic enzyme, mitochondrial (sprot)

An NADP-dependent malic enzyme, mitochondrial that is encoded in the genome of human.


oxygen metabolic process

The chemical reactions and pathways involving diatomic oxygen (O2).


RTN1_HUMAN Reticulon-1 (sprot)

A reticulon-1 that is encoded in the genome of human.


PHKG1_HUMAN Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (sprot)

A phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform that is encoded in the genome of human.


MEP1A_HUMAN Meprin A subunit alpha (sprot)

A meprin A subunit alpha that is encoded in the genome of human.


meprin A complex

A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues.


MEP1B_HUMAN Meprin A subunit beta (sprot)

A meprin A subunit beta that is encoded in the genome of human.


PPR3A_HUMAN Protein phosphatase 1 regulatory subunit 3A (sprot)

A protein phosphatase 1 regulatory subunit 3A that is encoded in the genome of human.


PCKGM_HUMAN Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (sprot)

A phosphoenolpyruvate carboxykinase [GTP], mitochondrial that is encoded in the genome of human.


Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products.


PTN21_HUMAN Tyrosine-protein phosphatase non-receptor type 21 (sprot)

A tyrosine-protein phosphatase non-receptor type 21 that is encoded in the genome of human.


PTPRO_HUMAN Receptor-type tyrosine-protein phosphatase O (sprot)

A receptor-type tyrosine-protein phosphatase O that is encoded in the genome of human.


DUS6_HUMAN Dual specificity protein phosphatase 6 (sprot)

A dual specificity protein phosphatase 6 that is encoded in the genome of human.


DUS7_HUMAN Dual specificity protein phosphatase 7 (sprot)

A dual specificity protein phosphatase 7 that is encoded in the genome of human.


UPP1_HUMAN Uridine phosphorylase 1 (sprot)

A uridine phosphorylase 1 that is encoded in the genome of human.


DDR2_HUMAN Discoidin domain-containing receptor 2 (sprot)

A discoidin domain-containing receptor 2 that is encoded in the genome of human.


HCDH_HUMAN Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (sprot)

A hydroxyacyl-coenzyme A dehydrogenase, mitochondrial that is encoded in the genome of human.


SIA4B_HUMAN CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (sprot)

A CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 that is encoded in the genome of human.


globoside biosynthetic process via lactosylceramide

The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group.


PTPRN_HUMAN Receptor-type tyrosine-protein phosphatase-like N (sprot)

A receptor-type tyrosine-protein phosphatase-like N that is encoded in the genome of human.


CP51A_HUMAN Lanosterol 14-alpha demethylase (sprot)

A lanosterol 14-alpha demethylase that is encoded in the genome of human.


sterol 14-demethylase activity

Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase].


UGPA_HUMAN UTP--glucose-1-phosphate uridylyltransferase (sprot)

A UTP--glucose-1-phosphate uridylyltransferase that is encoded in the genome of human.


Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose.


pyrimidine ribonucleotide binding

Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.


glucose 1-phosphate metabolic process

The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1.


AOC3_HUMAN Membrane primary amine oxidase (sprot)

A membrane primary amine oxidase that is encoded in the genome of human.


DGUOK_HUMAN Deoxyguanosine kinase, mitochondrial (sprot)

A deoxyguanosine kinase, mitochondrial that is encoded in the genome of human.


guanosine metabolic process

The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution.


dGTP metabolic process

The chemical reactions and pathways involving dGTP, guanosine triphosphate.


purine deoxyribonucleoside metabolic process

The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside).


VATF_HUMAN V-type proton ATPase subunit F (sprot)

A V-type proton ATPase subunit F that is encoded in the genome of human.


LTC4S_HUMAN Leukotriene C4 synthase (sprot)

A leukotriene C4 synthase that is encoded in the genome of human.


F263_HUMAN 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (sprot)

A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 that is encoded in the genome of human.


F264_HUMAN 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (sprot)

A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 that is encoded in the genome of human.


CDO1_HUMAN Cysteine dioxygenase type 1 (sprot)

A cysteine dioxygenase type 1 that is encoded in the genome of human.


cysteine dioxygenase activity

Catalysis of the reaction: L-cysteine + O2 = 3-sulfino-L-alanine + H+.


sulfur amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.


CGT_HUMAN 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (sprot)

A 2-hydroxyacylsphingosine 1-beta-galactosyltransferase that is encoded in the genome of human.


Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.


Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP.


TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic (sprot)

A thioredoxin reductase 1, cytoplasmic that is encoded in the genome of human.


NADPH peroxidase activity

Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+.


TPD53_HUMAN Tumor protein D53 (sprot)

A tumor protein D53 that is encoded in the genome of human.


MIC60_HUMAN MICOS complex subunit MIC60 (sprot)

A MICOS complex subunit MIC60 that is encoded in the genome of human.


mitochondrial crista junction

A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane.


MICOS complex

Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60.


TATD3_HUMAN Putative deoxyribonuclease TATDN3 (sprot)

A putative deoxyribonuclease TATDN3 that is encoded in the genome of human.


F187B_HUMAN Protein FAM187B (sprot)

A protein FAM187B that is encoded in the genome of human.


IMPG1_HUMAN Interphotoreceptor matrix proteoglycan 1 (sprot)

An interphotoreceptor matrix proteoglycan 1 that is encoded in the genome of human.


RHG44_HUMAN Rho GTPase-activating protein 44 (sprot)

A Rho GTPase-activating protein 44 that is encoded in the genome of human.


regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane

Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.


ZN827_HUMAN Zinc finger protein 827 (sprot)

A zinc finger protein 827 that is encoded in the genome of human.


NuRD complex binding

Binding to a NuRD complex.


negative regulation of shelterin complex assembly

Any process that stops, prevents or reduces the frequency, rate or extent of shelterin complex assembly.


RTL8B_HUMAN Retrotransposon Gag-like protein 8B (sprot)

A retrotransposon Gag-like protein 8B that is encoded in the genome of human.


LONF1_HUMAN LON peptidase N-terminal domain and RING finger protein 1 (sprot)

A LON peptidase N-terminal domain and RING finger protein 1 that is encoded in the genome of human.


SYT16_HUMAN Synaptotagmin-16 (sprot)

A synaptotagmin-16 that is encoded in the genome of human.


ODAPH_HUMAN Odontogenesis associated phosphoprotein (sprot)

An odontogenesis associated phosphoprotein that is encoded in the genome of human.


KCD19_HUMAN BTB/POZ domain-containing protein KCTD19 (sprot)

A BTB/POZ domain-containing protein KCTD19 that is encoded in the genome of human.


TPRXL_HUMAN Tetra-peptide repeat homeobox-like protein (sprot)


FA98C_HUMAN Protein FAM98C (sprot)

A protein FAM98C that is encoded in the genome of human.


TIGD6_HUMAN Tigger transposable element-derived protein 6 (sprot)

A tigger transposable element-derived protein 6 that is encoded in the genome of human.


NKPD1_HUMAN NTPase KAP family P-loop domain-containing protein 1 (sprot)

An NTPase KAP family P-loop domain-containing protein 1 that is encoded in the genome of human.


LIPR3_HUMAN Pancreatic lipase-related protein 3 (sprot)

A pancreatic lipase-related protein 3 that is encoded in the genome of human.


GEN_HUMAN Flap endonuclease GEN homolog 1 (sprot)

A flap endonuclease GEN homolog 1 that is encoded in the genome of human.


COOA1_HUMAN Collagen alpha-1(XXIV) chain (sprot)

A collagen alpha-1(XXIV) chain that is encoded in the genome of human.


CPEB4_HUMAN Cytoplasmic polyadenylation element-binding protein 4 (sprot)

A cytoplasmic polyadenylation element-binding protein 4 that is encoded in the genome of human.


LY6K_HUMAN Lymphocyte antigen 6K (sprot)

A lymphocyte antigen 6K that is encoded in the genome of human.


DOK7_HUMAN Protein Dok-7 (sprot)

A protein Dok-7 that is encoded in the genome of human.


ZSWM7_HUMAN Zinc finger SWIM domain-containing protein 7 (sprot)

A zinc finger SWIM domain-containing protein 7 that is encoded in the genome of human.


Shu complex

A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p.


ECSCR_HUMAN Endothelial cell-specific chemotaxis regulator (sprot)

An endothelial cell-specific chemotaxis regulator that is encoded in the genome of human.


T183B_HUMAN Putative transmembrane protein 183BP (sprot)

A putative transmembrane protein 183BP that is encoded in the genome of human.


KNOP1_HUMAN Lysine-rich nucleolar protein 1 (sprot)

A lysine-rich nucleolar protein 1 that is encoded in the genome of human.


SC5AC_HUMAN Sodium-coupled monocarboxylate transporter 2 (sprot)

A sodium-coupled monocarboxylate transporter 2 that is encoded in the genome of human.


organic acid:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in).


DOXA1_HUMAN Dual oxidase maturation factor 1 (sprot)

A dual oxidase maturation factor 1 that is encoded in the genome of human.


regulation of thyroid hormone generation

Any process that modulates the frequency, rate or extent of thyroid hormone generation.


DOXA2_HUMAN Dual oxidase maturation factor 2 (sprot)

A dual oxidase maturation factor 2 that is encoded in the genome of human.


HNRL2_HUMAN Heterogeneous nuclear ribonucleoprotein U-like protein 2 (sprot)

A heterogeneous nuclear ribonucleoprotein U-like protein 2 that is encoded in the genome of human.


LONF2_HUMAN LON peptidase N-terminal domain and RING finger protein 2 (sprot)

A LON peptidase N-terminal domain and RING finger protein 2 that is encoded in the genome of human.


MSMP_HUMAN Prostate-associated microseminoprotein (sprot)

A prostate-associated microseminoprotein that is encoded in the genome of human.


CSPP1_HUMAN Centrosome and spindle pole-associated protein 1 (sprot)

A centrosome and spindle pole-associated protein 1 that is encoded in the genome of human.


INSC_HUMAN Protein inscuteable homolog (sprot)

A protein inscuteable that is encoded in the genome of human.


SAMTR_HUMAN S-adenosylmethionine sensor upstream of mTORC1 (sprot)

An S-adenosylmethionine sensor upstream of mTORC1 that is encoded in the genome of human.


cellular response to methionine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus.


CCB42_HUMAN Putative chemokine-related protein B42 (sprot)


ESRG_HUMAN Embryonic stem cell-related gene protein (sprot)

An embryonic stem cell-related gene protein that is encoded in the genome of human.


ISK13_HUMAN Serine protease inhibitor Kazal-type 13 (sprot)

A serine protease inhibitor Kazal-type 13 that is encoded in the genome of human.


negative regulation of acrosome reaction

Any process that stops, prevents or reduces the frequency, rate or extent of acrosome reaction.


F110C_HUMAN Protein FAM110C (sprot)

A protein FAM110C that is encoded in the genome of human.


LRC36_HUMAN Leucine-rich repeat-containing protein 36 (sprot)

A leucine-rich repeat-containing protein 36 that is encoded in the genome of human.


SKDA1_HUMAN SKI/DACH domain-containing protein 1 (sprot)

A SKI/DACH domain-containing protein 1 that is encoded in the genome of human.


IZUM4_HUMAN Izumo sperm-egg fusion protein 4 (sprot)

An izumo sperm-egg fusion protein 4 that is encoded in the genome of human.


SWI5_HUMAN DNA repair protein SWI5 homolog (sprot)

A DNA repair protein SWI5 homolog that is encoded in the genome of human.


Swi5-Sfr1 complex

A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces).


T132A_HUMAN Transmembrane protein 132A (sprot)

A transmembrane protein 132A that is encoded in the genome of human.


positive regulation of Wnt protein secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell.


TM241_HUMAN Transmembrane protein 241 (sprot)

A transmembrane protein 241 that is encoded in the genome of human.


INF2_HUMAN Inverted formin-2 (sprot)

An inverted formin-2 that is encoded in the genome of human.


MICB_HUMAN MHC class I polypeptide-related sequence B (sprot)

An MHC class I polypeptide-related sequence B that is encoded in the genome of human.


MICA_HUMAN MHC class I polypeptide-related sequence A (sprot)

An MHC class I polypeptide-related sequence A that is encoded in the genome of human.


PDS5A_HUMAN Sister chromatid cohesion protein PDS5 homolog A (sprot)

A sister chromatid cohesion protein PDS5 homolog A that is encoded in the genome of human.


CL12B_HUMAN C-type lectin domain family 12 member B (sprot)

A C-type lectin domain family 12 member B that is encoded in the genome of human.


LRC26_HUMAN Leucine-rich repeat-containing protein 26 (sprot)

A leucine-rich repeat-containing protein 26 that is encoded in the genome of human.


positive regulation of voltage-gated potassium channel activity

Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity.


RSPO4_HUMAN R-spondin-4 (sprot)

An R-spondin-4 that is encoded in the genome of human.


MOONR_HUMAN Protein moonraker (sprot)

A protein that is a translation product of the KIAA0753 gene in human.


cytosolic ciliogenesis

The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm.


RN151_HUMAN RING finger protein 151 (sprot)

A RING finger protein 151 that is encoded in the genome of human.


RFX7_HUMAN DNA-binding protein RFX7 (sprot)

A DNA-binding protein RFX7 that is encoded in the genome of human.


QSER1_HUMAN Glutamine and serine-rich protein 1 (sprot)

A glutamine and serine-rich protein 1 that is encoded in the genome of human.


CL16A_HUMAN Protein CLEC16A (sprot)

A protein CLEC16A that is encoded in the genome of human.


negative regulation of autophagosome maturation

Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation.


GSG1_HUMAN Germ cell-specific gene 1 protein (sprot)

A germ cell-specific gene 1 protein that is encoded in the genome of human.


KI26B_HUMAN Kinesin-like protein KIF26B (sprot)

A kinesin-like protein KIF26B that is encoded in the genome of human.


ureteric bud invasion

The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros.


PRS53_HUMAN Serine protease 53 (sprot)

A serine protease 53 that is encoded in the genome of human.


BLTP1_HUMAN Bridge-like lipid transfer protein family member 1 (sprot)

A bridge-like lipid transfer protein family member 1 that is encoded in the genome of human.


ZN423_HUMAN Zinc finger protein 423 (sprot)

A zinc finger protein 423 that is encoded in the genome of human.


KIF7_HUMAN Kinesin-like protein KIF7 (sprot)

A kinesin-like protein KIF7 that is encoded in the genome of human.


ISX_HUMAN Intestine-specific homeobox (sprot)

An intestine-specific homeobox that is encoded in the genome of human.


RHG31_HUMAN Rho GTPase-activating protein 31 (sprot)

A Rho GTPase-activating protein 31 that is encoded in the genome of human.


ZN630_HUMAN Zinc finger protein 630 (sprot)

A zinc finger protein 630 that is encoded in the genome of human.


RN3P1_HUMAN Putative RRN3-like protein RRN3P1 (sprot)


CCD27_HUMAN Coiled-coil domain-containing protein 27 (sprot)

A coiled-coil domain-containing protein 27 that is encoded in the genome of human.


MTHSD_HUMAN Methenyltetrahydrofolate synthase domain-containing protein (sprot)

A methenyltetrahydrofolate synthase domain-containing protein that is encoded in the genome of human.


ODFP4_HUMAN Outer dense fiber protein 4 (sprot)

An outer dense fiber protein 4 that is encoded in the genome of human.


CE064_HUMAN Uncharacterized protein C5orf64 (sprot)

A protein that is a translation product of the C5orf64 gene in human.


MGAL_HUMAN Probable maltase-glucoamylase 2 (sprot)

A protein that is a translation product of the MGAM2 gene in human.


FA83E_HUMAN Protein FAM83E (sprot)

A protein FAM83E that is encoded in the genome of human.


K1C24_HUMAN Keratin, type I cytoskeletal 24 (sprot)

A keratin, type I cytoskeletal 24 that is encoded in the genome of human.


AAK1_HUMAN AP2-associated protein kinase 1 (sprot)

An AAK1 gene translation product (human), isoforms h1 and h2.


presynaptic endocytosis

A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.


CQ058_HUMAN UPF0450 protein C17orf58 (sprot)

A UPF0450 protein C17orf58 that is encoded in the genome of human.


KIZ_HUMAN Centrosomal protein kizuna (sprot)

A centrosomal protein kizuna that is encoded in the genome of human.


CCD96_HUMAN Coiled-coil domain-containing protein 96 (sprot)

A coiled-coil domain-containing protein 96 that is encoded in the genome of human.


MPEG1_HUMAN Macrophage-expressed gene 1 protein (sprot)

A macrophage-expressed gene 1 protein that is encoded in the genome of human.


dendritic cell antigen processing and presentation

The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.


antigen processing and presentation of exogenous peptide antigen

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell.


WASC4_HUMAN WASH complex subunit 4 (sprot)

A WASH complex subunit 4 that is encoded in the genome of human.


nuclear envelope budding

The process by which large macromolecular complexes are budded through the inner nuclear membrane, into the perinuclear space, thus acquiring a membrane envelope. The enveloped particle fuses with the outer nuclear membrane and is released into the cytoplasm.


TM266_HUMAN Transmembrane protein 266 (sprot)

A transmembrane protein 266 that is encoded in the genome of human.


voltage-gated channel activity

Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


SPKAP_HUMAN A-kinase anchor protein SPHKAP (sprot)

An A-kinase anchor protein SPHKAP that is encoded in the genome of human.


EX3L2_HUMAN Exocyst complex component 3-like protein 2 (sprot)

An exocyst complex component 3-like protein 2 that is encoded in the genome of human.


ABCB5_HUMAN ATP-binding cassette sub-family B member 5 (sprot)

An ATP-binding cassette sub-family B member 5 that is encoded in the genome of human.


SHRM1_HUMAN Protein Shroom1 (sprot)

A protein Shroom1 that is encoded in the genome of human.


SC5A9_HUMAN Sodium/glucose cotransporter 4 (sprot)

A sodium/glucose cotransporter 4 that is encoded in the genome of human.


S35G1_HUMAN Solute carrier family 35 member G1 (sprot)

A solute carrier family 35 member G1 that is encoded in the genome of human.


HYAL4_HUMAN Hyaluronidase-4 (sprot)

A hyaluronidase-4 that is encoded in the genome of human.


ZN181_HUMAN Zinc finger protein 181 (sprot)

A zinc finger protein 181 that is encoded in the genome of human.


ZN674_HUMAN Zinc finger protein 674 (sprot)

A zinc finger protein 674 that is encoded in the genome of human.


RGS21_HUMAN Regulator of G-protein signaling 21 (sprot)

A regulator of G-protein signaling 21 that is encoded in the genome of human.


SPRE3_HUMAN Sprouty-related, EVH1 domain-containing protein 3 (sprot)

A sprouty-related, EVH1 domain-containing protein 3 that is encoded in the genome of human.


RSPO1_HUMAN R-spondin-1 (sprot)

An R-spondin-1 that is encoded in the genome of human.


TECT1_HUMAN Tectonic-1 (sprot)

A tectonic-1 that is encoded in the genome of human.


central nervous system interneuron axonogenesis

Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region.


CTC1_HUMAN CST complex subunit CTC1 (sprot)

A CST complex subunit CTC1 that is encoded in the genome of human.


CST complex

A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection.


SGSM1_HUMAN Small G protein signaling modulator 1 (sprot)

A small G protein signaling modulator 1 that is encoded in the genome of human.


ERC6L_HUMAN DNA excision repair protein ERCC-6-like (sprot)

A DNA excision repair protein ERCC-6-like that is encoded in the genome of human.


CB068_HUMAN UPF0561 protein C2orf68 (sprot)

A UPF0561 protein C2orf68 that is encoded in the genome of human.


PARP6_HUMAN Protein mono-ADP-ribosyltransferase PARP6 (sprot)

A protein mono-ADP-ribosyltransferase PARP6 that is encoded in the genome of human.


NAD+- protein-cysteine ADP-ribosyltransferase activity

Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein].


PRSR3_HUMAN Proline and serine-rich protein 3 (sprot)

A proline and serine-rich protein 3 that is encoded in the genome of human.


TSR1_HUMAN Pre-rRNA-processing protein TSR1 homolog (sprot)

A pre-rRNA-processing protein TSR1 that is encoded in the genome of human.


VMAC_HUMAN Vimentin-type intermediate filament-associated coiled-coil protein (sprot)

A vimentin-type intermediate filament-associated coiled-coil protein that is encoded in the genome of human.


RGPA2_HUMAN Ral GTPase-activating protein subunit alpha-2 (sprot)

A Ral GTPase-activating protein subunit alpha-2 that is encoded in the genome of human.


D19L1_HUMAN Probable C-mannosyltransferase DPY19L1 (sprot)

A protein dpy-19 1 that is encoded in the genome of human.


LIN41_HUMAN E3 ubiquitin-protein ligase TRIM71 (sprot)

An E3 ubiquitin-protein ligase TRIM71 that is encoded in the genome of human.


RPEL1_HUMAN Ribulose-phosphate 3-epimerase-like protein 1 (sprot)

A protein that is a translation product of the RPEL1 gene in human.


ZXDC_HUMAN Zinc finger protein ZXDC (sprot)

A zinc finger protein ZXDC that is encoded in the genome of human.


MP17L_HUMAN Mpv17-like protein (sprot)

An Mpv17-like protein that is encoded in the genome of human.


TYSD1_HUMAN Peroxisomal leader peptide-processing protease (sprot)

A peroxisomal leader peptide-processing protease that is encoded in the genome of human.


TMM44_HUMAN Transmembrane protein 44 (sprot)

A transmembrane protein 44 that is encoded in the genome of human.


INSY1_HUMAN Inhibitory synaptic factor 1 (sprot)

An inhibitory synaptic factor 1 that is encoded in the genome of human.


IAH1_HUMAN Isoamyl acetate-hydrolyzing esterase 1 homolog (sprot)

An isoamyl acetate-hydrolyzing esterase 1 that is encoded in the genome of human.


ALG11_HUMAN GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (sprot)

A GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that is encoded in the genome of human.


alpha-1,2-mannosyltransferase activity

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.


TXIP1_HUMAN Translin-associated factor X-interacting protein 1 (sprot)

A translin-associated factor X-interacting protein 1 that is encoded in the genome of human.


CCD57_HUMAN Coiled-coil domain-containing protein 57 (sprot)

A coiled-coil domain-containing protein 57 that is encoded in the genome of human.


KIF19_HUMAN Kinesin-like protein KIF19 (sprot)

A kinesin-like protein KIF19 that is encoded in the genome of human.


axonemal microtubule depolymerization

The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules.


plus-end specific microtubule depolymerization

The removal of tubulin heterodimers from the plus end of a microtubule.


PWP3A_HUMAN PWWP domain-containing DNA repair factor 3A (sprot)

A PWWP domain-containing DNA repair factor 3A that is encoded in the genome of human.


VWC2_HUMAN Brorin (sprot)

A brorin that is encoded in the genome of human.


QRIC1_HUMAN Transcriptional regulator QRICH1 (sprot)

A transcriptional regulator QRICH1 that is encoded in the genome of human.


GOG7B_HUMAN Golgin subfamily A member 7B (sprot)

A golgin subfamily A member 7B that is encoded in the genome of human.


SMU1_HUMAN WD40 repeat-containing protein SMU1 (sprot)

A WD40 repeat-containing protein SMU1 that is encoded in the genome of human.


ATG2A_HUMAN Autophagy-related protein 2 homolog A (sprot)

An autophagy-related protein 2 homolog A that is encoded in the genome of human.


ZN800_HUMAN Zinc finger protein 800 (sprot)

A zinc finger protein 800 that is encoded in the genome of human.


ASTE1_HUMAN Protein asteroid homolog 1 (sprot)

A protein asteroid homolog 1 that is encoded in the genome of human.


HKDC1_HUMAN Hexokinase HKDC1 (sprot)

A hexokinase HKDC1 that is encoded in the genome of human.


KLH40_HUMAN Kelch-like protein 40 (sprot)

A kelch-like protein 40 that is encoded in the genome of human.


PRIC4_HUMAN Prickle-like protein 4 (sprot)

A prickle-like protein 4 that is encoded in the genome of human.


C19L2_HUMAN CWF19-like protein 2 (sprot)

A CWF19-like protein 2 that is encoded in the genome of human.


WSCD2_HUMAN Sialate:O-sulfotransferase 2 (sprot)

A WSC domain-containing protein 2 that is encoded in the genome of human.


MST1L_HUMAN Putative macrophage stimulating 1-like protein (sprot)

A protein that is a translation product of the MST1L gene in human.


COSA1_HUMAN Collagen alpha-1(XXVIII) chain (sprot)

A collagen alpha-1(XXVIII) chain that is encoded in the genome of human.


FHOD3_HUMAN FH1/FH2 domain-containing protein 3 (sprot)

An FH1/FH2 domain-containing protein 3 that is encoded in the genome of human.


KIF4B_HUMAN Chromosome-associated kinesin KIF4B (sprot)

A chromosome-associated kinesin KIF4B that is encoded in the genome of human.


IF2GL_HUMAN Eukaryotic translation initiation factor 2 subunit 3B (sprot)

A protein that is a translation product of the EIF2S3B gene in human.


CR1L_HUMAN Complement component receptor 1-like protein (sprot)

A complement component receptor 1-like protein that is encoded in the genome of human.


AP5B1_HUMAN AP-5 complex subunit beta-1 (sprot)

An AP-5 complex subunit beta-1 that is encoded in the genome of human.


CTU2_HUMAN Cytoplasmic tRNA 2-thiolation protein 2 (sprot)

A cytoplasmic tRNA 2-thiolation protein 2 that is encoded in the genome of human.


protein urmylation

Covalent attachment of the ubiquitin-like protein URM1 to another protein.


SKOR2_HUMAN SKI family transcriptional corepressor 2 (sprot)

A ladybird homeobox corepressor 1-like protein that is encoded in the genome of human.


regulation of cerebellar granule cell precursor proliferation

The process that modulates the frequency, rate or extent of granule cell precursor proliferation.


PRTG_HUMAN Protogenin (sprot)

A protogenin that is encoded in the genome of human.


ZN284_HUMAN Zinc finger protein 284 (sprot)

A zinc finger protein 284 that is encoded in the genome of human.


LETM2_HUMAN LETM1 domain-containing protein LETM2, mitochondrial (sprot)

A LETM1 domain-containing protein LETM2, mitochondrial that is encoded in the genome of human.


CEA16_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 16 (sprot)

A carcinoembryonic antigen-related cell adhesion molecule 16 that is encoded in the genome of human.


KLH38_HUMAN Kelch-like protein 38 (sprot)

A kelch-like protein 38 that is encoded in the genome of human.


TM249_HUMAN Cation channel sperm-associated auxiliary subunit TMEM249 (sprot)

A cation channel sperm-associated auxiliary subunit TMEM249 that is encoded in the genome of human.


FR1L6_HUMAN Fer-1-like protein 6 (sprot)

A Fer-1-like protein 6 that is encoded in the genome of human.


GAB4_HUMAN GRB2-associated-binding protein 4 (sprot)

A GRB2-associated-binding protein 4 that is encoded in the genome of human.


S4A8_HUMAN Electroneutral sodium bicarbonate exchanger 1 (sprot)

An electroneutral sodium bicarbonate exchanger 1 that is encoded in the genome of human.


positive regulation of synaptic vesicle exocytosis

Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).


sodium ion transmembrane transporter activity

Enables the transfer of sodium ions (Na+) from one side of a membrane to the other.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction chloride(in) + 2 hydrogencarbonate(out) + Na+(out) = chloride(out) + 2 hydrogencarbonate(in) + Na+(in).


UVSSA_HUMAN UV-stimulated scaffold protein A (sprot)

A UV-stimulated scaffold protein A that is encoded in the genome of human.


DRB5_HUMAN HLA class II histocompatibility antigen, DR beta 5 chain (sprot)

An MHC class II histocompatibility antigen beta chain DRB5 that is encoded in the genome of human.


HFE_HUMAN Hereditary hemochromatosis protein (sprot)

A hereditary hemochromatosis protein that is encoded in the genome of human.


negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I

Any process that stops, prevents or reduces the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I.


TR16L_HUMAN Tripartite motif-containing protein 16-like protein (sprot)

A tripartite motif-containing protein 16-like protein that is encoded in the genome of human.


DB136_HUMAN Defensin beta 136 (sprot)

A defensin beta 136 that is encoded in the genome of human.


DB135_HUMAN Beta-defensin 135 (sprot)

A beta-defensin 135 that is encoded in the genome of human.


DB133_HUMAN Beta-defensin 133 (sprot)

A beta-defensin 133 that is encoded in the genome of human.


DB116_HUMAN Beta-defensin 116 (sprot)

A beta-defensin 116 that is encoded in the genome of human.


DB115_HUMAN Beta-defensin 115 (sprot)

A beta-defensin 115 that is encoded in the genome of human.


DB114_HUMAN Beta-defensin 114 (sprot)

A beta-defensin 114 that is encoded in the genome of human.


DB113_HUMAN Beta-defensin 113 (sprot)

A beta-defensin 113 that is encoded in the genome of human.


DB112_HUMAN Beta-defensin 112 (sprot)

A beta-defensin 112 that is encoded in the genome of human.


DB110_HUMAN Beta-defensin 110 (sprot)

A beta-defensin 110 that is encoded in the genome of human.


DB109_HUMAN Putative beta-defensin 109B (sprot)

A putative beta-defensin 109B that is encoded in the genome of human.


ANO4_HUMAN Anoctamin-4 (sprot)

An anoctamin-4 that is encoded in the genome of human.


ZN699_HUMAN Zinc finger protein 699 (sprot)

A zinc finger protein 699 that is encoded in the genome of human.


PGGHG_HUMAN Protein-glucosylgalactosylhydroxylysine glucosidase (sprot)

A protein-glucosylgalactosylhydroxylysine glucosidase that is encoded in the genome of human.


Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins.


ATOSA_HUMAN Atos homolog protein A (sprot)

An Atos homolog protein A that is encoded in the genome of human.


MYLK3_HUMAN Myosin light chain kinase 3 (sprot)

A myosin light chain kinase 3 that is encoded in the genome of human.


ZN750_HUMAN Zinc finger protein 750 (sprot)

A zinc finger protein 750 that is encoded in the genome of human.


LRRF1_HUMAN Leucine-rich repeat flightless-interacting protein 1 (sprot)

A leucine-rich repeat flightless-interacting protein 1 that is encoded in the genome of human.


PGPS1_HUMAN CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (sprot)

A CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial that is encoded in the genome of human.


Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+.


P3H1_HUMAN Prolyl 3-hydroxylase 1 (sprot)

A prolyl 3-hydroxylase 1 that is encoded in the genome of human.


Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.


TRM5_HUMAN tRNA (guanine(37)-N1)-methyltransferase (sprot)

A tRNA (guanine-N(1)-)-methyltransferase that is encoded in the genome of human.


Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine.


mitochondrial tRNA methylation

The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule.


EMAL3_HUMAN Echinoderm microtubule-associated protein-like 3 (sprot)

An echinoderm microtubule-associated protein-like 3 that is encoded in the genome of human.


RA1L2_HUMAN Heterogeneous nuclear ribonucleoprotein A1-like 2 (sprot)

A heterogeneous nuclear ribonucleoprotein A1-like 2 that is encoded in the genome of human.


PLPR5_HUMAN Phospholipid phosphatase-related protein type 5 (sprot)

A phospholipid phosphatase-related protein type 5 that is encoded in the genome of human.


NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 (sprot)

An NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 that is encoded in the genome of human.


RFX4_HUMAN Transcription factor RFX4 (sprot)

A transcription factor RFX4 that is encoded in the genome of human.


LRRK1_HUMAN Leucine-rich repeat serine/threonine-protein kinase 1 (sprot)

A leucine-rich repeat serine/threonine-protein kinase 1 that is encoded in the genome of human.


RPA43_HUMAN DNA-directed RNA polymerase I subunit RPA43 (sprot)

A DNA-directed RNA polymerase I subunit RPA43 that is encoded in the genome of human.


GFOD2_HUMAN Glucose-fructose oxidoreductase domain-containing protein 2 (sprot)

A glucose-fructose oxidoreductase domain-containing protein 2 that is encoded in the genome of human.


SMI21_HUMAN Small integral membrane protein 21 (sprot)

A protein that is a translation product of the SMIM21 gene in human.


EDRF1_HUMAN Erythroid differentiation-related factor 1 (sprot)

An erythroid differentiation-related factor 1 that is encoded in the genome of human.


BEAN1_HUMAN Protein BEAN1 (sprot)

A protein BEAN that is encoded in the genome of human.


F161A_HUMAN Protein FAM161A (sprot)

A protein FAM161A that is encoded in the genome of human.


LEG9B_HUMAN Galectin-9B (sprot)

A galectin-9B that is encoded in the genome of human.


PROX2_HUMAN Prospero homeobox protein 2 (sprot)

A prospero homeobox protein 2 that is encoded in the genome of human.


system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.


NBPF1_HUMAN Neuroblastoma breakpoint family member 1 (sprot)

A neuroblastoma breakpoint family member 1 that is encoded in the genome of human.


NBPF8_HUMAN Putative neuroblastoma breakpoint family member 8 (sprot)

A putative neuroblastoma breakpoint family member 8 that is encoded in the genome of human.


BSH_HUMAN Brain-specific homeobox protein homolog (sprot)

A brain-specific homeobox protein that is encoded in the genome of human.


ACOT6_HUMAN Acyl-coenzyme A thioesterase 6 (sprot)

An acyl-coenzyme A thioesterase 6 that is encoded in the genome of human.


PTHD3_HUMAN Patched domain-containing protein 3 (sprot)

A patched domain-containing protein 3 that is encoded in the genome of human.


ZN829_HUMAN Zinc finger protein 829 (sprot)

A zinc finger protein 829 that is encoded in the genome of human.


NSN5B_HUMAN Putative NOL1/NOP2/Sun domain family member 5B (sprot)


TMM95_HUMAN Sperm-egg fusion protein TMEM95 (sprot)

A sperm-egg fusion protein TMEM95 that is encoded in the genome of human.


PCGF3_HUMAN Polycomb group RING finger protein 3 (sprot)

A Polycomb group RING finger protein 3 that is encoded in the genome of human.


SNAI3_HUMAN Zinc finger protein SNAI3 (sprot)

A zinc finger protein SNAI3 that is encoded in the genome of human.


SOAT_HUMAN Sodium-dependent organic anion transporter (sprot)

A sodium-dependent organic anion transporter that is encoded in the genome of human.


sodium-dependent organic anion transmembrane transporter activity

Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner.


sodium-dependent organic anion transport

The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


MAJIN_HUMAN Membrane-anchored junction protein (sprot)

A membrane-anchored junction protein that is encoded in the genome of human.


ZN791_HUMAN Zinc finger protein 791 (sprot)

A zinc finger protein 791 that is encoded in the genome of human.


ANR55_HUMAN Ankyrin repeat domain-containing protein 55 (sprot)

An ankyrin repeat domain-containing protein 55 that is encoded in the genome of human.


INAVA_HUMAN Innate immunity activator protein (sprot)

An innate immunity activator protein that is encoded in the genome of human.


MA7D1_HUMAN MAP7 domain-containing protein 1 (sprot)

A MAP7 domain-containing protein 1 that is encoded in the genome of human.


ZN792_HUMAN Zinc finger protein 792 (sprot)

A zinc finger protein 792 that is encoded in the genome of human.


S2535_HUMAN Solute carrier family 25 member 35 (sprot)

A solute carrier family 25 member 35 that is encoded in the genome of human.


PKHG6_HUMAN Pleckstrin homology domain-containing family G member 6 (sprot)

A pleckstrin homology domain-containing family G member 6 that is encoded in the genome of human.


ASTRB_HUMAN Protein Aster-B (sprot)

A protein Aster-B that is encoded in the genome of human.


CB076_HUMAN UPF0538 protein C2orf76 (sprot)

A UPF0538 protein C2orf76 that is encoded in the genome of human.


ALKB6_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 (sprot)

An alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 that is encoded in the genome of human.


RHGBB_HUMAN Inactive Rho GTPase-activating protein 11B (sprot)

A Rho GTPase-activating protein 11B that is encoded in the genome of human.


CHD9_HUMAN Chromodomain-helicase-DNA-binding protein 9 (sprot)

A chromodomain-helicase-DNA-binding protein 9 that is encoded in the genome of human.


KR251_HUMAN Keratin-associated protein 25-1 (sprot)

A keratin-associated protein 25-1 that is encoded in the genome of human.


KR213_HUMAN Keratin-associated protein 21-3 (sprot)

A keratin-associated protein 21-3 that is encoded in the genome of human.


KR192_HUMAN Keratin-associated protein 19-2 (sprot)

A primate-type keratin-associated protein 19-2 that is encoded in the genome of human.


KR198_HUMAN Keratin-associated protein 19-8 (sprot)

A keratin-associated protein 19-8 that is encoded in the genome of human.


KR211_HUMAN Keratin-associated protein 21-1 (sprot)

A keratin-associated protein 21-1 that is encoded in the genome of human.


KR212_HUMAN Keratin-associated protein 21-2 (sprot)

A keratin-associated protein 21-2 that is encoded in the genome of human.


KR203_HUMAN Keratin-associated protein 20-3 (sprot)

A keratin-associated protein 20-3 that is encoded in the genome of human.


KR202_HUMAN Keratin-associated protein 20-2 (sprot)

A keratin-associated protein 20-2 that is encoded in the genome of human.


KR204_HUMAN Putative keratin-associated protein 20-4 (sprot)

A putative keratin-associated protein 20-4 that is encoded in the genome of human.


KR201_HUMAN Keratin-associated protein 20-1 (sprot)

A keratin-associated protein 20-1 that is encoded in the genome of human.


KRA61_HUMAN Keratin-associated protein 6-1 (sprot)

A keratin-associated protein 6-1 that is encoded in the genome of human.


KRA62_HUMAN Keratin-associated protein 6-2 (sprot)

A keratin-associated protein 6-2 that is encoded in the genome of human.


KRA63_HUMAN Keratin-associated protein 6-3 (sprot)

A keratin-associated protein 6-3 that is encoded in the genome of human.


KR222_HUMAN Keratin-associated protein 22-2 (sprot)

A keratin-associated protein 22-2 that is encoded in the genome of human.


KR196_HUMAN Keratin-associated protein 19-6 (sprot)

A keratin-associated protein 19-6 that is encoded in the genome of human.


KR195_HUMAN Keratin-associated protein 19-5 (sprot)

A keratin-associated protein 19-5 that is encoded in the genome of human.


KR194_HUMAN Keratin-associated protein 19-4 (sprot)

A keratin-associated protein 19-4 that is encoded in the genome of human.


KR151_HUMAN Keratin-associated protein 15-1 (sprot)

A keratin-associated protein 15-1 that is encoded in the genome of human.


KR134_HUMAN Keratin-associated protein 13-4 (sprot)

A keratin-associated protein 13-4 that is encoded in the genome of human.


KR271_HUMAN Keratin-associated protein 27-1 (sprot)

A keratin-associated protein 27-1 that is encoded in the genome of human.


KR241_HUMAN Keratin-associated protein 24-1 (sprot)

A keratin-associated protein 24-1 that is encoded in the genome of human.


ADPRM_HUMAN Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (sprot)

A manganese-dependent ADP-ribose/CDP-alcohol diphosphatase that is encoded in the genome of human.


TKFC_HUMAN Triokinase/FMN cyclase (sprot)

A triokinase/FMN cyclase that is encoded in the genome of human.


glycerone kinase activity

Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+.


FAD-AMP lyase (cyclizing) activity

Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate.


triokinase activity

Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H+.


LSM12_HUMAN Protein LSM12 (sprot)

A protein LSM12 that is encoded in the genome of human.


TBC25_HUMAN TBC1 domain family member 25 (sprot)

A TBC1 domain family member 25 that is encoded in the genome of human.


RGL3_HUMAN Ral guanine nucleotide dissociation stimulator-like 3 (sprot)

A Ral guanine nucleotide dissociation stimulator-like 3 that is encoded in the genome of human.


IPIL2_HUMAN Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 (sprot)

An inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 that is encoded in the genome of human.


CC50B_HUMAN Cell cycle control protein 50B (sprot)

A cell cycle control protein 50B that is encoded in the genome of human.


aminophospholipid flippase activity

Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group.


ZN528_HUMAN Zinc finger protein 528 (sprot)

A zinc finger protein 528 that is encoded in the genome of human.


PUS10_HUMAN tRNA pseudouridine synthase Pus10 (sprot)

A tRNA pseudouridine synthase Pus10 that is encoded in the genome of human.


tRNA pseudouridine synthase activity

Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.


tRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.


KR221_HUMAN Keratin-associated protein 22-1 (sprot)

A keratin-associated protein 22-1 that is encoded in the genome of human.


MUCL3_HUMAN Mucin-like protein 3 (sprot)

A mucin-like protein 3 that is encoded in the genome of human.


ADCK5_HUMAN Uncharacterized aarF domain-containing protein kinase 5 (sprot)

An uncharacterized aarF domain-containing protein kinase 5 that is encoded in the genome of human.


WDR72_HUMAN WD repeat-containing protein 72 (sprot)

A WD repeat-containing protein 72 that is encoded in the genome of human.


PA24E_HUMAN Cytosolic phospholipase A2 epsilon (sprot)

A cytosolic phospholipase A2 epsilon that is encoded in the genome of human.


Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains.


ZSC23_HUMAN Zinc finger and SCAN domain-containing protein 23 (sprot)

A zinc finger and SCAN domain-containing protein 23 that is encoded in the genome of human.


PIGY_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y (sprot)

A phosphatidylinositol N-acetylglucosaminyltransferase subunit Y that is encoded in the genome of human.


OD3L2_HUMAN Outer dense fiber protein 3-like protein 2 (sprot)

An outer dense fiber protein 3-like protein 2 that is encoded in the genome of human.


HSDL1_HUMAN Inactive hydroxysteroid dehydrogenase-like protein 1 (sprot)

A hydroxysteroid dehydrogenase-like protein 1 that is encoded in the genome of human.