negative regulation of pancreatic juice secretion

Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.


negative regulation of secretion of lysosomal enzymes

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.


LIPA1_HUMAN Liprin-alpha-1 (sprot)

A liprin-alpha-1 that is encoded in the genome of human.


CACO2_HUMAN Calcium-binding and coiled-coil domain-containing protein 2 (sprot)

A calcium-binding and coiled-coil domain-containing protein 2 that is encoded in the genome of human.


EI2BE_HUMAN Translation initiation factor eIF-2B subunit epsilon (sprot)

A translation initiation factor eIF-2B subunit epsilon that is encoded in the genome of human.


BAMBI_HUMAN BMP and activin membrane-bound inhibitor homolog (sprot)

A BMP and activin membrane-bound inhibitor that is encoded in the genome of human.


TADBP_HUMAN TAR DNA-binding protein 43 (sprot)

A TAR DNA-binding protein 43 that is encoded in the genome of human.


nuclear inner membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane.


ROA0_HUMAN Heterogeneous nuclear ribonucleoprotein A0 (sprot)

A heterogeneous nuclear ribonucleoprotein A0 that is encoded in the genome of human.


PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (sprot)

A serine/threonine-protein kinase PAK 1 that is encoded in the genome of human.


AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (sprot)

An aminoacyl tRNA synthase complex-interacting multifunctional protein 2 that is encoded in the genome of human.


RFA4_HUMAN Replication protein A 30 kDa subunit (sprot)

A replication protein A 30 kDa subunit that is encoded in the genome of human.


nuclear DNA replication

The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.


FADD_HUMAN FAS-associated death domain protein (sprot)

A FAS-associated death domain protein that is encoded in the genome of human.


death effector domain binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).


negative regulation of activation-induced cell death of T cells

Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells.


positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation.


PRDX4_HUMAN Peroxiredoxin-4 (sprot)

A peroxiredoxin-4 that is encoded in the genome of human.


MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 (sprot)

A dual specificity mitogen-activated protein kinase kinase 5 that is encoded in the genome of human.


MK07_HUMAN Mitogen-activated protein kinase 7 (sprot)

A mitogen-activated protein kinase 7 that is encoded in the genome of human.


CATR1_HUMAN CATR tumorigenic conversion 1 protein (sprot)

A CATR tumorigenic conversion 1 protein that is encoded in the genome of human.


PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (sprot)

A serine/threonine-protein kinase PAK 2 that is encoded in the genome of human.


negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.


S13A2_HUMAN Solute carrier family 13 member 2 (sprot)

A solute carrier family 13 member 2 that is encoded in the genome of human.


fumarate transmembrane transporter activity

Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.


alpha-ketoglutarate transmembrane transporter activity

Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle.


low-affinity sodium:dicarboxylate symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in).


fumarate transport

The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


CBX3_HUMAN Chromobox protein homolog 3 (sprot)

A chromobox protein homolog 3 that is encoded in the genome of human.


STK3_HUMAN Serine/threonine-protein kinase 3 (sprot)

A serine/threonine-protein kinase 3 that is encoded in the genome of human.


STX5_HUMAN Syntaxin-5 (sprot)

A syntaxin-5 that is encoded in the genome of human.


CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (sprot)

An E3 ubiquitin-protein ligase CBL-B that is encoded in the genome of human.


PSMD2_HUMAN 26S proteasome non-ATPase regulatory subunit 2 (sprot)

A 26S proteasome non-ATPase regulatory subunit 2 that is encoded in the genome of human.


MMRN1_HUMAN Multimerin-1 (sprot)

A multimerin-1 that is encoded in the genome of human.


multimerin complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Glycoprotein complex of the C1q/TNF superfamily involved in cell adhesion. A homotrimer that will combine to form supramolecular Multimerin structures.


DUS8_HUMAN Dual specificity protein phosphatase 8 (sprot)

A dual specificity protein phosphatase 8 that is encoded in the genome of human.


MYBPH_HUMAN Myosin-binding protein H (sprot)

A myosin-binding protein H that is encoded in the genome of human.


DDX10_HUMAN Probable ATP-dependent RNA helicase DDX10 (sprot)

A probable ATP-dependent RNA helicase DDX10 that is encoded in the genome of human.


TBX2_HUMAN T-box transcription factor TBX2 (sprot)

A T-box transcription factor TBX2 that is encoded in the genome of human.


pigment metabolic process involved in pigmentation

The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell.


negative regulation of heart looping

Any process that stops, prevents or reduces the frequency, rate or extent of heart looping.


negative regulation of cardiac chamber formation

Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation.


SEM3B_HUMAN Semaphorin-3B (sprot)

A semaphorin-3B that is encoded in the genome of human.


ERCC8_HUMAN DNA excision repair protein ERCC-8 (sprot)

A DNA excision repair protein ERCC-8 that is encoded in the genome of human.


regulation of transcription-coupled nucleotide-excision repair

Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.


DNJC3_HUMAN DnaJ homolog subfamily C member 3 (sprot)

A DnaJ homolog subfamily C member 3 that is encoded in the genome of human.


positive regulation of translation initiation in response to endoplasmic reticulum stress

Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.


PAPP1_HUMAN Pappalysin-1 (sprot)

A pappalysin-1 that is encoded in the genome of human.


NMDE2_HUMAN Glutamate receptor ionotropic, NMDA 2B (sprot)

A glutamate receptor ionotropic, NMDA 2B that is encoded in the genome of human.


GPS2_HUMAN G protein pathway suppressor 2 (sprot)

A G protein pathway suppressor 2 that is encoded in the genome of human.


negative regulation of protein K63-linked ubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination.


SBP1_HUMAN Methanethiol oxidase (sprot)

A methanethiol oxidase that is encoded in the genome of human.


methanethiol oxidase activity

Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide.


CHIT1_HUMAN Chitotriosidase-1 (sprot)

A chitotriosidase-1 that is encoded in the genome of human.


endochitinase activity

Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain.


polysaccharide catabolic process

The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


chitin catabolic process

The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.


NDK3_HUMAN Nucleoside diphosphate kinase 3 (sprot)

A nucleoside diphosphate kinase 3 that is encoded in the genome of human.


M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 (sprot)

A mitogen-activated protein kinase kinase kinase 1 that is encoded in the genome of human.


KGP2_HUMAN cGMP-dependent protein kinase 2 (sprot)

A cGMP-dependent protein kinase 2 that is encoded in the genome of human.


cGMP-dependent protein kinase activity

cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


tetrahydrobiopterin metabolic process

The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.


SLAP1_HUMAN Src-like-adapter (sprot)

A Src-like-adapter that is encoded in the genome of human.


KLRD1_HUMAN Natural killer cells antigen CD94 (sprot)

A killer cell lectin-like receptor subfamily D member 1 that is encoded in the genome of human.


MHC class Ib protein binding, via antigen binding groove

Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove.


SRSF9_HUMAN Serine/arginine-rich splicing factor 9 (sprot)

A serine/arginine-rich splicing factor 9 that is encoded in the genome of human.


SRSF5_HUMAN Serine/arginine-rich splicing factor 5 (sprot)

A serine/arginine-rich splicing factor 5 that is encoded in the genome of human.


SRSF6_HUMAN Serine/arginine-rich splicing factor 6 (sprot)

A serine/arginine-rich splicing factor 6 that is encoded in the genome of human.


NOGG_HUMAN Noggin (sprot)

A noggin that is encoded in the genome of human.


negative regulation of cardiac epithelial to mesenchymal transition

Any process that stops or decreases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


GRM1_HUMAN Metabotropic glutamate receptor 1 (sprot)

A metabotropic glutamate receptor 1 that is encoded in the genome of human.


G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse.


G protein-coupled receptor dimeric complex

A protein complex that contains two G protein-coupled receptors.


G protein-coupled receptor homodimeric complex

A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor.


MD2L1_HUMAN Mitotic spindle assembly checkpoint protein MAD2A (sprot)

A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of human.


mitotic spindle assembly checkpoint MAD1-MAD2 complex

A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex.


PD2R_HUMAN Prostaglandin D2 receptor (sprot)

A prostaglandin D2 receptor that is encoded in the genome of human.


prostaglandin J receptor activity

Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.


prostaglandin D receptor activity

Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.


I15RA_HUMAN Interleukin-15 receptor subunit alpha (sprot)

An interleukin-15 receptor subunit alpha that is encoded in the genome of human.


TIF1B_HUMAN Transcription intermediary factor 1-beta (sprot)

A transcription intermediary factor 1-beta that is encoded in the genome of human.


Krueppel-associated box domain binding

Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.


positive regulation of DNA methylation-dependent heterochromatin formation

Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation.


DHRS2_HUMAN Dehydrogenase/reductase SDR family member 2, mitochondrial (sprot)

A dehydrogenase/reductase SDR family member 2, mitochondrial that is encoded in the genome of human.


SEM3F_HUMAN Semaphorin-3F (sprot)

A semaphorin-3F that is encoded in the genome of human.


STX3_HUMAN Syntaxin-3 (sprot)

A syntaxin-3 that is encoded in the genome of human.


organelle membrane fusion

The joining of two lipid bilayers to form a single organelle membrane.


G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (sprot)

A Ras GTPase-activating protein-binding protein 1 that is encoded in the genome of human.


DNA/RNA helicase activity

Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis.


positive regulation of stress granule assembly

Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.


STF1_HUMAN Steroidogenic factor 1 (sprot)

A steroidogenic factor 1 that is encoded in the genome of human.


primary sex determination

The sex determination process that results in the initial specification of sexual status of an individual organism.


response to gonadotropin-releasing hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


CLN3_HUMAN Battenin (sprot)

A battenin that is encoded in the genome of human.


regulation of autophagosome size

Any process that modulates the size of the autophagosome.


The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.


phagosome-lysosome docking

The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere.


regulation of cellular response to osmotic stress

Any process that modulates the frequency, rate or extent of the cellular response to osmotic stress.


regulation of arginine biosynthetic process

Any process that modulates the frequency, rate or extent of arginine biosynthetic process.


regulation of phagosome maturation

Any process that modulates the frequency, rate or extent of phagosome maturation.


NMI_HUMAN N-myc-interactor (sprot)

An N-myc-interactor that is encoded in the genome of human.


SLAF1_HUMAN Signaling lymphocytic activation molecule (sprot)

A SLAM family member 1 that is encoded in the genome of human.


myeloid dendritic cell activation involved in immune response

The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


regulation of vesicle fusion

Any process that modulates the frequency, rate or extent of vesicle fusion.


SG2A2_HUMAN Mammaglobin-A (sprot)

A mammaglobin-A that is encoded in the genome of human.


KCAB2_HUMAN Voltage-gated potassium channel subunit beta-2 (sprot)

A voltage-gated potassium channel subunit beta-2 that is encoded in the genome of human.


pinceau fiber

Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment.


GPR17_HUMAN Uracil nucleotide/cysteinyl leukotriene receptor (sprot)

A uracil nucleotide/cysteinyl leukotriene receptor that is encoded in the genome of human.


PTK7_HUMAN Inactive tyrosine-protein kinase 7 (sprot)

An inactive tyrosine-protein kinase 7 that is encoded in the genome of human.


axis elongation

The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.


convergent extension

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.


SKP2_HUMAN S-phase kinase-associated protein 2 (sprot)

An S-phase kinase-associated protein 2 that is encoded in the genome of human.


PABP4_HUMAN Polyadenylate-binding protein 4 (sprot)

A polyadenylate-binding protein 4 that is encoded in the genome of human.


ATM_HUMAN Serine-protein kinase ATM (sprot)

A serine-protein kinase ATM that is encoded in the genome of human.


regulation of telomerase activity

Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.


cellular response to nitrosative stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.


establishment of RNA localization to telomere

The directed movement of RNA to a specific location in the telomeric region of a chromosome.


establishment of protein-containing complex localization to telomere

The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome.


positive regulation of DNA catabolic process

Any process that activates or increases the frequency, rate or extent of DNA catabolic process.


positive regulation of telomerase catalytic core complex assembly

Any process that activates or increases the frequency, rate or extent of telomerase catalytic core complex assembly.


DMP1_HUMAN Dentin matrix acidic phosphoprotein 1 (sprot)

A dentin matrix acidic phosphoprotein 1 that is encoded in the genome of human.


CD5R2_HUMAN Cyclin-dependent kinase 5 activator 2 (sprot)

A cyclin-dependent kinase 5 activator 2 that is encoded in the genome of human.


superior olivary nucleus maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


GRB10_HUMAN Growth factor receptor-bound protein 10 (sprot)

A growth factor receptor-bound protein 10 that is encoded in the genome of human.


BIK_HUMAN Bcl-2-interacting killer (sprot)

A Bcl-2-interacting killer that is encoded in the genome of human.


CRFR2_HUMAN Corticotropin-releasing factor receptor 2 (sprot)

A corticotropin-releasing factor receptor 2 that is encoded in the genome of human.


IFIT5_HUMAN Interferon-induced protein with tetratricopeptide repeats 5 (sprot)

An interferon-induced protein with tetratricopeptide repeats 5 that is encoded in the genome of human.


SGCG_HUMAN Gamma-sarcoglycan (sprot)

A gamma-sarcoglycan that is encoded in the genome of human.


MTA1_HUMAN Metastasis-associated protein MTA1 (sprot)

A metastasis-associated protein MTA1 that is encoded in the genome of human.


PTPRS_HUMAN Receptor-type tyrosine-protein phosphatase S (sprot)

A receptor-type tyrosine-protein phosphatase S that is encoded in the genome of human.


trans-synaptic signaling

Cell-cell signaling in either direction across the synaptic cleft.


UT1_HUMAN Urea transporter 1 (sprot)

A urea transporter 1 that is encoded in the genome of human.


SP140_HUMAN Nuclear body protein SP140 (sprot)

A nuclear body protein SP140 that is encoded in the genome of human.


EIF3I_HUMAN Eukaryotic translation initiation factor 3 subunit I (sprot)

A eukaryotic translation initiation factor 3 subunit I that is encoded in the genome of human.


ITAD_HUMAN Integrin alpha-D (sprot)

An integrin alpha-D that is encoded in the genome of human.


KLF1_HUMAN Krueppel-like factor 1 (sprot)

A krueppel-like factor 1 that is encoded in the genome of human.


CENPR_HUMAN Centromere protein R (sprot)

A centromere protein R that is encoded in the genome of human.


PPIL2_HUMAN RING-type E3 ubiquitin-protein ligase PPIL2 (sprot)

A RING-type E3 ubiquitin-protein ligase PPIL2 that is encoded in the genome of human.


ZN177_HUMAN Zinc finger protein 177 (sprot)

A zinc finger protein 177 that is encoded in the genome of human.


MFAP5_HUMAN Microfibrillar-associated protein 5 (sprot)

A microfibrillar-associated protein 5 that is encoded in the genome of human.


2A5G_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (sprot)

A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform that is encoded in the genome of human.


CTBP1_HUMAN C-terminal-binding protein 1 (sprot)

A C-terminal-binding protein 1 that is encoded in the genome of human.


AP3B2_HUMAN AP-3 complex subunit beta-2 (sprot)

An AP-3 complex subunit beta-2 that is encoded in the genome of human.


MPP3_HUMAN MAGUK p55 subfamily member 3 (sprot)

A MAGUK p55 subfamily member 3 that is encoded in the genome of human.


PDE3B_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (sprot)

A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B that is encoded in the genome of human.


cGMP-inhibited cyclic-nucleotide phosphodiesterase activity

Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP.


PHLP_HUMAN Phosducin-like protein (sprot)

A phosducin-like protein that is encoded in the genome of human.


JIP2_HUMAN C-Jun-amino-terminal kinase-interacting protein 2 (sprot)

A C-Jun-amino-terminal kinase-interacting protein 2 that is encoded in the genome of human.


nonassociative learning

A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment.


PLD1_HUMAN Phospholipase D1 (sprot)

A phospholipase D1 that is encoded in the genome of human.


MB211_HUMAN Putative nucleotidyltransferase MAB21L1 (sprot)

A putative nucleotidyltransferase MAB21L1 that is encoded in the genome of human.


TARB1_HUMAN Probable methyltransferase TARBP1 (sprot)

A probable methyltransferase TARBP1 that is encoded in the genome of human.


ZN211_HUMAN Zinc finger protein 211 (sprot)

A zinc finger protein 211 that is encoded in the genome of human.


PM2P3_HUMAN Putative postmeiotic segregation increased 2-like protein 3 (sprot)

A putative postmeiotic segregation increased 2-like protein 3 that is encoded in the genome of human.


MYO7A_HUMAN Unconventional myosin-VIIa (sprot)

A myosin-VIIa that is encoded in the genome of human.


pigment granule transport

The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


upper tip-link density

An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends.


myosin VII complex

A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain.


UB2V1_HUMAN Ubiquitin-conjugating enzyme E2 variant 1 (sprot)

A ubiquitin-conjugating enzyme E2 variant 1 that is encoded in the genome of human.


RM49_HUMAN Large ribosomal subunit protein mL49 (sprot)

A 39S ribosomal protein L49, mitochondrial that is encoded in the genome of human.


DC1I2_HUMAN Cytoplasmic dynein 1 intermediate chain 2 (sprot)

A cytoplasmic dynein 1 intermediate chain 2 that is encoded in the genome of human.


BT1A1_HUMAN Butyrophilin subfamily 1 member A1 (sprot)

A butyrophilin subfamily 1 member A1 that is encoded in the genome of human.


ORC1_HUMAN Origin recognition complex subunit 1 (sprot)

An origin recognition complex subunit 1 that is encoded in the genome of human.


ORC2_HUMAN Origin recognition complex subunit 2 (sprot)

An origin recognition complex subunit 2 that is encoded in the genome of human.


ILK_HUMAN Integrin-linked protein kinase (sprot)

An integrin-linked protein kinase that is encoded in the genome of human.


MSLN_HUMAN Mesothelin (sprot)

A mesothelin that is encoded in the genome of human.


IKZF1_HUMAN DNA-binding protein Ikaros (sprot)

A DNA-binding protein Ikaros that is encoded in the genome of human.


NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial (sprot)

An NAD(P) transhydrogenase, mitochondrial that is encoded in the genome of human.


NAD(P)+ transhydrogenase (B-specific) activity

Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.


SNTA1_HUMAN Alpha-1-syntrophin (sprot)

An alpha-1-syntrophin that is encoded in the genome of human.


regulation of vasoconstriction by circulating norepinephrine

Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.


SNTB2_HUMAN Beta-2-syntrophin (sprot)

A beta-2-syntrophin that is encoded in the genome of human.


XRCC4_HUMAN DNA repair protein XRCC4 (sprot)

A DNA repair protein XRCC4 that is encoded in the genome of human.


FHA domain binding

Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich.


positive regulation of ligase activity

Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.


PPIG_HUMAN Peptidyl-prolyl cis-trans isomerase G (sprot)

A peptidyl-prolyl cis-trans isomerase G that is encoded in the genome of human.


TCOF_HUMAN Treacle protein (sprot)

A treacle protein that is encoded in the genome of human.


U119A_HUMAN Protein unc-119 homolog A (sprot)

A protein unc-119 homolog A that is encoded in the genome of human.


negative regulation of clathrin-dependent endocytosis

Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis.


negative regulation of caveolin-mediated endocytosis

Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis.


S39A6_HUMAN Zinc transporter ZIP6 (sprot)

A zinc transporter ZIP6 that is encoded in the genome of human.


lymphocyte activation

A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.


zinc ion import across plasma membrane

The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol.


MKRN4_HUMAN Putative E3 ubiquitin-protein ligase makorin-4 (sprot)


SF3B2_HUMAN Splicing factor 3B subunit 2 (sprot)

A splicing factor 3B subunit 2 that is encoded in the genome of human.


OS9_HUMAN Protein OS-9 (sprot)

A protein OS-9 that is encoded in the genome of human.


Hrd1p ubiquitin ligase complex

A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).


GOGA4_HUMAN Golgin subfamily A member 4 (sprot)

A golgin subfamily A member 4 that is encoded in the genome of human.


HAP28_HUMAN 28 kDa heat- and acid-stable phosphoprotein (sprot)

A 28 kDa heat- and acid-stable phosphoprotein that is encoded in the genome of human.


ADAM9_HUMAN Disintegrin and metalloproteinase domain-containing protein 9 (sprot)

A disintegrin and metalloproteinase domain-containing protein 9 that is encoded in the genome of human.


response to antineoplastic agent

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms.


ADA15_HUMAN Disintegrin and metalloproteinase domain-containing protein 15 (sprot)

A disintegrin and metalloproteinase domain-containing protein 15 that is encoded in the genome of human.


TMED1_HUMAN Transmembrane emp24 domain-containing protein 1 (sprot)

A transmembrane emp24 domain-containing protein 1 that is encoded in the genome of human.


LSAMP_HUMAN Limbic system-associated membrane protein (sprot)

A limbic system-associated membrane protein that is encoded in the genome of human.


FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP5 that is encoded in the genome of human.


TUSC3_HUMAN Tumor suppressor candidate 3 (sprot)

A tumor suppressor candidate 3 that is encoded in the genome of human.


MYO9B_HUMAN Unconventional myosin-IXb (sprot)

A myosin-IXb that is encoded in the genome of human.


FOXE3_HUMAN Forkhead box protein E3 (sprot)

A forkhead box protein E3 that is encoded in the genome of human.


trabecular meshwork development

The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.


ROCK1_HUMAN Rho-associated protein kinase 1 (sprot)

A Rho-associated protein kinase 1 that is encoded in the genome of human.


amyloid-beta complex

Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease.


apical constriction

The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.


FZD5_HUMAN Frizzled-5 (sprot)

A frizzled-5 that is encoded in the genome of human.


regulation of chorionic trophoblast cell proliferation

Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation.


NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (sprot)

A nuclear factor of activated T-cells, cytoplasmic 2 that is encoded in the genome of human.


ncRNA transcription

The transcription of non (protein) coding RNA from a DNA template.


TNK1_HUMAN Non-receptor tyrosine-protein kinase TNK1 (sprot)

A non-receptor tyrosine-protein kinase TNK1 that is encoded in the genome of human.


TOP3A_HUMAN DNA topoisomerase 3-alpha (sprot)

A DNA topoisomerase 3-alpha that is encoded in the genome of human.


DRP2_HUMAN Dystrophin-related protein 2 (sprot)

A dystrophin-related protein 2 that is encoded in the genome of human.


MADCA_HUMAN Mucosal addressin cell adhesion molecule 1 (sprot)

A mucosal addressin cell adhesion molecule 1 that is encoded in the genome of human.


IL18R_HUMAN Interleukin-18 receptor 1 (sprot)

An interleukin-18 receptor 1 that is encoded in the genome of human.


GAB1_HUMAN GRB2-associated-binding protein 1 (sprot)

A GRB2-associated-binding protein 1 that is encoded in the genome of human.


endothelial cell chemotaxis to vascular endothelial growth factor

The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF).


SMAD4_HUMAN Mothers against decapentaplegic homolog 4 (sprot)

A smad4 that is encoded in the genome of human.


positive regulation of cell proliferation involved in heart valve morphogenesis

Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.


formation of anatomical boundary

The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.


regulation of hair follicle development

Any process that modulates the frequency, rate or extent of hair follicle development.


female gonad morphogenesis

The process in which a female gonad is generated and organized.


negative regulation of cardiac myofibril assembly

Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly.


SNPC2_HUMAN snRNA-activating protein complex subunit 2 (sprot)

An snRNA-activating protein complex subunit 2 that is encoded in the genome of human.


snRNA transcription

The synthesis of small nuclear RNA (snRNA) from a DNA template.


VPP3_HUMAN V-type proton ATPase 116 kDa subunit a 3 (sprot)

A V-type proton ATPase 116 kDa subunit a 3 that is encoded in the genome of human.


response to silver ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus.


dentin mineralization

The process in which calcium salts are deposited into the calcareous tooth structure known as dentin.


BIRC3_HUMAN Baculoviral IAP repeat-containing protein 3 (sprot)

A baculoviral IAP repeat-containing protein 3 that is encoded in the genome of human.


regulation of RIG-I signaling pathway

Any process that modulates the frequency, rate or extent of the RIG-I signaling pathway.


BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (sprot)

A baculoviral IAP repeat-containing protein 2 that is encoded in the genome of human.


negative regulation of ripoptosome assembly involved in necroptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process.


GPM6B_HUMAN Neuronal membrane glycoprotein M6-b (sprot)

A neuronal membrane glycoprotein M6-b that is encoded in the genome of human.


PICAL_HUMAN Phosphatidylinositol-binding clathrin assembly protein (sprot)

A phosphatidylinositol-binding clathrin assembly protein that is encoded in the genome of human.


membrane bending

A membrane organization process resulting in the bending of a membrane.


regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.


negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process.


MAMD1_HUMAN Mastermind-like domain-containing protein 1 (sprot)

A mastermind-like domain-containing protein 1 that is encoded in the genome of human.


MTM1_HUMAN Myotubularin (sprot)

A myotubularin that is encoded in the genome of human.


regulation of vacuole organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.


SQSTM_HUMAN Sequestosome-1 (sprot)

A sequestosome-1 that is encoded in the genome of human.


K63-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein.


aggrephagy

Selective degradation of protein aggregates by macroautophagy.


amphisome

Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes.


MED21_HUMAN Mediator of RNA polymerase II transcription subunit 21 (sprot)

A mediator of RNA polymerase II transcription subunit 21 that is encoded in the genome of human.


MTX1_HUMAN Metaxin-1 (sprot)

A metaxin-1 that is encoded in the genome of human.


NAB1_HUMAN NGFI-A-binding protein 1 (sprot)

An NGFI-A-binding protein 1 that is encoded in the genome of human.


TRPC3_HUMAN Short transient receptor potential channel 3 (sprot)

A short transient receptor potential cation channel TRPC3 that is encoded in the genome of human.


calcium activated cation channel activity

Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.


NAR3_HUMAN Ecto-ADP-ribosyltransferase 3 (sprot)

An ecto-ADP-ribosyltransferase 3 that is encoded in the genome of human.


TBB3_HUMAN Tubulin beta-3 chain (sprot)

A tubulin beta-3 chain that is encoded in the genome of human.


ASAH1_HUMAN Acid ceramidase (sprot)

An acid ceramidase that is encoded in the genome of human.


regulation of programmed necrotic cell death

Any process that modulates the frequency, rate or extent of programmed necrotic cell death.


BFSP2_HUMAN Phakinin (sprot)

A phakinin that is encoded in the genome of human.


OLIG2_HUMAN Oligodendrocyte transcription factor 2 (sprot)

An oligodendrocyte transcription factor 2 that is encoded in the genome of human.


PNOC_HUMAN Prepronociceptin (sprot)

A nociceptin that is encoded in the genome of human.


AQP6_HUMAN Aquaporin-6 (sprot)

An aquaporin-6 that is encoded in the genome of human.


nitrate transmembrane transport

The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


PPR1A_HUMAN Protein phosphatase 1 regulatory subunit 1A (sprot)

A protein phosphatase 1 regulatory subunit 1A that is encoded in the genome of human.


PRP4B_HUMAN Serine/threonine-protein kinase PRP4 homolog (sprot)

A serine/threonine-protein kinase PRP4 that is encoded in the genome of human.


PIN1_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (sprot)

A peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 that is encoded in the genome of human.


cis-trans isomerase activity

Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers.


SERC3_HUMAN Serine incorporator 3 (sprot)

A serine incorporator 3 that is encoded in the genome of human.


ATR_HUMAN Serine/threonine-protein kinase ATR (sprot)

A serine/threonine-protein kinase ATR that is encoded in the genome of human.


ATR-ATRIP complex

A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A.


CROC4_HUMAN Protein CROC-4 (sprot)

A protein that is a translation product of the MIR9-1HG gene in human.


4EBP1_HUMAN Eukaryotic translation initiation factor 4E-binding protein 1 (sprot)

A eukaryotic translation initiation factor 4E-binding protein 1 that is encoded in the genome of human.


4EBP2_HUMAN Eukaryotic translation initiation factor 4E-binding protein 2 (sprot)

A eukaryotic translation initiation factor 4E-binding protein 2 that is encoded in the genome of human.


RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (sprot)

A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human.


positive regulation of miRNA processing

Any process that activates or increases the frequency, rate or extent of microRNA processing.


positive regulation of interleukin-6-mediated signaling pathway

Any process that increases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.


regulation of ATP:ADP antiporter activity

Any process that modulates the activity of an ATP:ADP antiporter.


ripoptosome assembly

The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.


ripoptosome assembly involved in necroptotic process

The aggregation, arrangement and bonding together of ripoptosome components leading to a necroptotic process.


HDAC1_HUMAN Histone deacetylase 1 (sprot)

A histone deacetylase 1 that is encoded in the genome of human.


KCC2B_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit beta (sprot)

A calcium/calmodulin-dependent protein kinase type II subunit beta that is encoded in the genome of human.


calcium-dependent protein serine/threonine kinase activity

Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.


regulation of skeletal muscle adaptation

Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.


calcium- and calmodulin-dependent protein kinase complex

An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.


KCC2G_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit gamma (sprot)

A calcium/calmodulin-dependent protein kinase type II subunit gamma that is encoded in the genome of human.


KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit delta (sprot)

A calcium/calmodulin-dependent protein kinase type II subunit delta that is encoded in the genome of human.


regulation of cellular localization

Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.


negative regulation of sodium ion transmembrane transport

Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport.


DCTN2_HUMAN Dynactin subunit 2 (sprot)

A dynactin subunit 2 that is encoded in the genome of human.


NDF1_HUMAN Neurogenic differentiation factor 1 (sprot)

A neurogenic differentiation factor 1 that is encoded in the genome of human.


regulation of intestinal epithelial structure maintenance

Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.


PKD2_HUMAN Polycystin-2 (sprot)

A polycystin-2 that is encoded in the genome of human.


HLH domain binding

Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.


detection of nodal flow

The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry.


metanephric smooth muscle tissue development

The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure.


metanephric cortex development

The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros.


metanephric cortical collecting duct development

The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex.


metanephric distal tubule development

The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule.


ULA1_HUMAN NEDD8-activating enzyme E1 regulatory subunit (sprot)

A NEDD8-activating enzyme E1 regulatory subunit that is encoded in the genome of human.


NEDD8 activating enzyme activity

Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.


mitotic DNA replication checkpoint signaling

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A signal transduction process that contributes to a mitotic DNA replication checkpoint.


IRF5_HUMAN Interferon regulatory factor 5 (sprot)

An interferon regulatory factor 5 that is encoded in the genome of human.


TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (sprot)

A G/T mismatch-specific thymine DNA glycosylase that is encoded in the genome of human.


G/U mismatch-specific uracil-DNA glycosylase activity

Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil and leaving an apyrimidinic (AP) site.


G/T mismatch-specific thymine-DNA glycosylase activity

Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine and leaving an apyrimidinic (AP) site.


LAPM5_HUMAN Lysosomal-associated transmembrane protein 5 (sprot)

A lysosomal-associated transmembrane protein 5 that is encoded in the genome of human.


induction of programmed cell death

A process which directly activates any of the steps required for programmed cell death.


positive regulation of lysosomal membrane permeability

Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.


negative regulation of autophagic cell death

Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death.


ITPK1_HUMAN Inositol-tetrakisphosphate 1-kinase (sprot)

An inositol-tetrakisphosphate 1-kinase that is encoded in the genome of human.


inositol tetrakisphosphate 6-kinase activity

Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.


inositol tetrakisphosphate 1-kinase activity

Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.


Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H+.


Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+.


SNW1_HUMAN SNW domain-containing protein 1 (sprot)

A SNW domain-containing protein 1 that is encoded in the genome of human.


DGKZ_HUMAN Diacylglycerol kinase zeta (sprot)

A diacylglycerol kinase zeta that is encoded in the genome of human.


IQGA2_HUMAN Ras GTPase-activating-like protein IQGAP2 (sprot)

A Ras GTPase-activating-like protein IQGAP2 that is encoded in the genome of human.


MTR1L_HUMAN Melatonin-related receptor (sprot)

A melatonin-related receptor that is encoded in the genome of human.


STIM1_HUMAN Stromal interaction molecule 1 (sprot)

A stromal interaction molecule 1 that is encoded in the genome of human.


activation of store-operated calcium channel activity

A process that initiates the activity of an inactive store-operated calcium channel.


GRAP_HUMAN GRB2-related adapter protein (sprot)

A GRB2-related adapter protein that is encoded in the genome of human.


SEM5A_HUMAN Semaphorin-5A (sprot)

A semaphorin-5A that is encoded in the genome of human.


signal clustering

Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response.


TRA2A_HUMAN Transformer-2 protein homolog alpha (sprot)

A transformer-2 protein homolog alpha that is encoded in the genome of human.


SNX1_HUMAN Sorting nexin-1 (sprot)

A sorting nexin-1 that is encoded in the genome of human.


KRR1_HUMAN KRR1 small subunit processome component homolog (sprot)

A KRR1 small subunit processome component that is encoded in the genome of human.


OR5I1_HUMAN Olfactory receptor 5I1 (sprot)

An olfactory receptor 5I1 that is encoded in the genome of human.


OR2F1_HUMAN Olfactory receptor 2F1 (sprot)

An olfactory receptor 2F1 that is encoded in the genome of human.


PEX6_HUMAN Peroxisomal ATPase PEX6 (sprot)

A peroxisomal ATPase PEX6 that is encoded in the genome of human.


photoreceptor cell cilium

A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment.


DNSL3_HUMAN Deoxyribonuclease gamma (sprot)

A deoxyribonuclease gamma that is encoded in the genome of human.


PWP1_HUMAN Periodic tryptophan protein 1 homolog (sprot)

A periodic tryptophan protein 1 that is encoded in the genome of human.


H4K20me3 modified histone binding

Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation.


MTMR1_HUMAN Myotubularin-related protein 1 (sprot)

A myotubularin-related protein 1 that is encoded in the genome of human.


MTMR2_HUMAN Myotubularin-related protein 2 (sprot)

A myotubularin-related protein 2 that is encoded in the genome of human.


negative regulation of receptor catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process.


MTMR3_HUMAN Myotubularin-related protein 3 (sprot)

A myotubularin-related protein 3 that is encoded in the genome of human.


phosphatidylinositol 5-phosphate metabolic process

The chemical reactions and pathways involving phosphatidylinositol 5-phosphate.


CUL1_HUMAN Cullin-1 (sprot)

A fungal/metazoan cullin-1 that is encoded in the genome of human.


CUL2_HUMAN Cullin-2 (sprot)

A cullin-2 that is encoded in the genome of human.


VCB complex

A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.


CUL3_HUMAN Cullin-3 (sprot)

A cullin-3 that is encoded in the genome of human.


POZ domain binding

Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.


trophectodermal cellular morphogenesis

The morphogenesis of trophectoderm cells.


nuclear protein quality control by the ubiquitin-proteasome system

The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation.


regulation protein catabolic process at postsynapse

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.


CUL4A_HUMAN Cullin-4A (sprot)

A cullin-4A that is encoded in the genome of human.


CUL4B_HUMAN Cullin-4B (sprot)

A cullin-4B that is encoded in the genome of human.


S12A1_HUMAN Solute carrier family 12 member 1 (sprot)

A solute carrier family 12 member 1 that is encoded in the genome of human.


ASPP2_HUMAN Apoptosis-stimulating of p53 protein 2 (sprot)

An apoptosis-stimulating of p53 protein 2 that is encoded in the genome of human.


DYR1A_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1A (sprot)

A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of human.


histone H3T45 kinase activity

Catalysis of the reaction: histone H3-threonine (position 45) + ATP = histone H3-phosphothreonine (position 45) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 45 of histone H3.


FCL_HUMAN GDP-L-fucose synthase (sprot)

A GDP-L-fucose synthetase that is encoded in the genome of human.


Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed.


GDP-mannose 3,5-epimerase activity

Catalysis of the reaction: GDP-mannose = GDP-L-galactose.


GDP-L-fucose synthase activity

Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+.


CAD18_HUMAN Cadherin-18 (sprot)

A cadherin-18 that is encoded in the genome of human.


PTC1_HUMAN Protein patched homolog 1 (sprot)

A protein patched homolog 1 that is encoded in the genome of human.


smoothened binding

Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals.


hedgehog family protein binding

Binding to a member of the hedgehog protein family, signaling proteins involved in development.


neural tube patterning

The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.


neural plate axis specification

The pattern specification process in which the axes of the nervous system are established.


RAB31_HUMAN Ras-related protein Rab-31 (sprot)

A Ras-related protein Rab-31 that is encoded in the genome of human.


early phagosome membrane

The lipid bilayer surrounding an early phagosome.


RAB32_HUMAN Ras-related protein Rab-32 (sprot)

A Ras-related protein Rab-32 that is encoded in the genome of human.


5HT4R_HUMAN 5-hydroxytryptamine receptor 4 (sprot)

A 5-hydroxytryptamine receptor 4 that is encoded in the genome of human.


serotonin receptor activity

Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.


large intestinal transit

Migration of ingested material along the length of the large intestine.


TPBG_HUMAN Trophoblast glycoprotein (sprot)

A trophoblast glycoprotein that is encoded in the genome of human.


FHL1_HUMAN Four and a half LIM domains protein 1 (sprot)

A four and a half LIM domains protein 1 that is encoded in the genome of human.


FHL3_HUMAN Four and a half LIM domains protein 3 (sprot)

A four and a half LIM domains protein 3 that is encoded in the genome of human.


I10R1_HUMAN Interleukin-10 receptor subunit alpha (sprot)

An interleukin-10 receptor subunit alpha that is encoded in the genome of human.


interleukin-10 binding

Binding to interleukin-10.


PM2PB_HUMAN Putative postmeiotic segregation increased 2-like protein 11 (sprot)

A putative postmeiotic segregation increased 2-like protein 11 that is encoded in the genome of human.


RIN1_HUMAN Ras and Rab interactor 1 (sprot)

A Ras and Rab interactor 1 that is encoded in the genome of human.


ITA7_HUMAN Integrin alpha-7 (sprot)

An integrin alpha-7 that is encoded in the genome of human.


AAMP_HUMAN Angio-associated migratory cell protein (sprot)

An angio-associated migratory cell protein that is encoded in the genome of human.


ALKB1_HUMAN Nucleic acid dioxygenase ALKBH1 (sprot)

A nucleic acid dioxygenase ALKBH1 that is encoded in the genome of human.


Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.


oxidative RNA demethylase activity

Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.


oxidative DNA demethylase activity

Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2.


tRNA demethylase activity

Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule.


tRNA wobble cytosine modification

The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.


oxidative RNA demethylation

The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms.


RNA repair

Any process that results in the repair of damaged RNA.


tRNA demethylation

The removal of a methyl group from one or more residues within a tRNA molecule.


CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1S that is encoded in the genome of human.


RAPSN_HUMAN 43 kDa receptor-associated protein of the synapse (sprot)

A 43 kDa receptor-associated protein of the synapse that is encoded in the genome of human.


structural constituent of postsynaptic specialization

The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.


regulation of postsynaptic membrane organization

Any process that modulates the frequency, rate or extent of postsynaptic membrane organization.


establishment of protein localization to postsynaptic membrane

The directed movement of a protein to a specific location in a postsynaptic membrane.


AVR2B_HUMAN Activin receptor type-2B (sprot)

An activin receptor type-2B that is encoded in the genome of human.


activin receptor activity, type II

Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor.


MOGS_HUMAN Mannosyl-oligosaccharide glucosidase (sprot)

A mannosyl-oligosaccharide glucosidase that is encoded in the genome of human.


Glc3Man9GlcNAc2 oligosaccharide glucosidase activity

Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).


glucosidase activity

Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative.


AT1A4_HUMAN Sodium/potassium-transporting ATPase subunit alpha-4 (sprot)

A sodium/potassium-transporting ATPase subunit alpha-4 that is encoded in the genome of human.


CD166_HUMAN CD166 antigen (sprot)

A CD166 molecule that is encoded in the genome of human.


LAMB3_HUMAN Laminin subunit beta-3 (sprot)

A laminin subunit beta-3 that is encoded in the genome of human.


LAMC2_HUMAN Laminin subunit gamma-2 (sprot)

A laminin subunit gamma-2 that is encoded in the genome of human.


RUNX3_HUMAN Runt-related transcription factor 3 (sprot)

A runt-related transcription factor 3 that is encoded in the genome of human.


THOC5_HUMAN THO complex subunit 5 homolog (sprot)

A THO complex subunit 5 that is encoded in the genome of human.


viral mRNA export from host cell nucleus

The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation.


negative regulation of DNA damage checkpoint

Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint.


THO complex

The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.


THO complex part of transcription export complex

The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.


NCOA4_HUMAN Nuclear receptor coactivator 4 (sprot)

A nuclear receptor coactivator 4 that is encoded in the genome of human.


APOF_HUMAN Apolipoprotein F (sprot)

An apolipoprotein F that is encoded in the genome of human.


APR_HUMAN Phorbol-12-myristate-13-acetate-induced protein 1 (sprot)

A phorbol-12-myristate-13-acetate-induced protein 1 that is encoded in the genome of human.


response to dsRNA

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus.


ARFRP_HUMAN ADP-ribosylation factor-related protein 1 (sprot)

An ADP-ribosylation factor-related protein 1 that is encoded in the genome of human.


SHRM2_HUMAN Protein Shroom2 (sprot)

A protein Shroom2 that is encoded in the genome of human.


eye pigment granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye.


establishment of melanosome localization

The directed movement of a melanosome to a specific location.


cellular pigment accumulation

The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus.


ITA9_HUMAN Integrin alpha-9 (sprot)

An integrin alpha-9 that is encoded in the genome of human.


SPTN1_HUMAN Spectrin alpha chain, non-erythrocytic 1 (sprot)

A spectrin alpha chain, non-erythrocytic 1 that is encoded in the genome of human.


ENPP2_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (sprot)

An ectonucleotide pyrophosphatase/phosphodiesterase family member 2 that is encoded in the genome of human.


NOG2_HUMAN Nucleolar GTP-binding protein 2 (sprot)

A nucleolar GTP-binding protein 2 that is encoded in the genome of human.


AUHM_HUMAN Methylglutaconyl-CoA hydratase, mitochondrial (sprot)

A methylglutaconyl-CoA hydratase, mitochondrial that is encoded in the genome of human.


methylglutaconyl-CoA hydratase activity

Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O.


itaconyl-CoA hydratase activity

Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O.


BACD2_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (sprot)

A BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 that is encoded in the genome of human.


PKP1_HUMAN Plakophilin-1 (sprot)

A plakophilin-1 that is encoded in the genome of human.


DX39B_HUMAN Spliceosome RNA helicase DDX39B (sprot)

A spliceosome RNA helicase BAT1 that is encoded in the genome of human.


U6 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.


BLMH_HUMAN Bleomycin hydrolase (sprot)

A bleomycin hydrolase that is encoded in the genome of human.


cysteine-type aminopeptidase activity

Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


EXOS2_HUMAN Exosome complex component RRP4 (sprot)

An exosome complex component RRP4 that is encoded in the genome of human.


BMPR2_HUMAN Bone morphogenetic protein receptor type-2 (sprot)

A BMP receptor type-2 that is encoded in the genome of human.


semi-lunar valve development

The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure.


MOBP_HUMAN Myelin-associated oligodendrocyte basic protein (sprot)

A myelin-associated oligodendrocyte basic protein that is encoded in the genome of human.


PTK6_HUMAN Protein-tyrosine kinase 6 (sprot)

A protein-tyrosine kinase 6 that is encoded in the genome of human.


SNTB1_HUMAN Beta-1-syntrophin (sprot)

A beta-1-syntrophin that is encoded in the genome of human.


TBB2A_HUMAN Tubulin beta-2A chain (sprot)

A tubulin beta-2A chain that is encoded in the genome of human.


KLF9_HUMAN Krueppel-like factor 9 (sprot)

A krueppel-like factor 9 that is encoded in the genome of human.


cellular response to cortisol stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.


KLF5_HUMAN Krueppel-like factor 5 (sprot)

A krueppel-like factor 5 that is encoded in the genome of human.


positive regulation of transcription by transcription factor localization

Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.


cell-cell signaling via exosome

Cell-cell signaling in which the ligand is carried between cells by an exosome.


TF2H2_HUMAN General transcription factor IIH subunit 2 (sprot)

A general transcription factor IIH subunit 2 that is encoded in the genome of human.


positive regulation of DNA helicase activity

Any process that activates or increases the frequency, rate or extent of ATP-dependent DNA helicase activity.


core TFIIH complex portion of holo TFIIH complex

The core TFIIH complex when it is part of the general transcription factor TFIIH.


TF2H3_HUMAN General transcription factor IIH subunit 3 (sprot)

A general transcription factor IIH subunit 3 that is encoded in the genome of human.


BYST_HUMAN Bystin (sprot)

A bystin that is encoded in the genome of human.


C1D_HUMAN Nuclear nucleic acid-binding protein C1D (sprot)

A nuclear nucleic acid-binding protein C1D that is encoded in the genome of human.


RPGF1_HUMAN Rap guanine nucleotide exchange factor 1 (sprot)

A Rap guanine nucleotide exchange factor 1 that is encoded in the genome of human.


IDI1_HUMAN Isopentenyl-diphosphate Delta-isomerase 1 (sprot)

An isopentenyl-diphosphate Delta-isomerase 1 that is encoded in the genome of human.


dimethylallyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate.


CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human.


calcium-mediated signaling using extracellular calcium source

The series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response.


CAYP1_HUMAN Calcyphosin (sprot)

A calcyphosin that is encoded in the genome of human.


CALI_HUMAN Calicin (sprot)

A calicin that is encoded in the genome of human.


PDE7A_HUMAN High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (sprot)

A high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A that is encoded in the genome of human.


RUNX2_HUMAN Runt-related transcription factor 2 (sprot)

A runt-related transcription factor 2 that is encoded in the genome of human.


osteoblast fate commitment

The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.


ligamentous ossification

Ossification wherein bone tissue forms within ligamentous tissue.


PEBB_HUMAN Core-binding factor subunit beta (sprot)

A core-binding factor subunit beta that is encoded in the genome of human.


NFYC_HUMAN Nuclear transcription factor Y subunit gamma (sprot)

A nuclear transcription factor Y subunit gamma that is encoded in the genome of human.


CNCG_HUMAN Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)

A retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma that is encoded in the genome of human.


RGRF1_HUMAN Ras-specific guanine nucleotide-releasing factor 1 (sprot)

A Ras-specific guanine nucleotide-releasing factor 1 that is encoded in the genome of human.


KGP1_HUMAN cGMP-dependent protein kinase 1 (sprot)

A cGMP-dependent protein kinase 1 that is encoded in the genome of human.


CEAM7_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 7 (sprot)

A carcinoembryonic antigen-related cell adhesion molecule 7 that is encoded in the genome of human.


KCNC3_HUMAN Potassium voltage-gated channel subfamily C member 3 (sprot)

A voltage-gated potassium channel KCNC3 that is encoded in the genome of human.


CDK13_HUMAN Cyclin-dependent kinase 13 (sprot)

A cyclin-dependent kinase 13 that is encoded in the genome of human.


nuclear cyclin-dependent protein kinase holoenzyme complex

Cyclin-dependent protein kinase (CDK) complex found in the nucleus.


IL16_HUMAN Pro-interleukin-16 (sprot)

An interleukin-16 that is encoded in the genome of human.


CKAP5_HUMAN Cytoskeleton-associated protein 5 (sprot)

A cytoskeleton-associated protein 5 that is encoded in the genome of human.


CIRBP_HUMAN Cold-inducible RNA-binding protein (sprot)

A cold-inducible RNA-binding protein that is encoded in the genome of human.


KCC1A_HUMAN Calcium/calmodulin-dependent protein kinase type 1 (sprot)

A calcium/calmodulin-dependent protein kinase type 1 that is encoded in the genome of human.


COTL1_HUMAN Coactosin-like protein (sprot)

A coactosin-like protein that is encoded in the genome of human.


CNGB1_HUMAN Cyclic nucleotide-gated cation channel beta-1 (sprot)

A cyclic nucleotide-gated cation channel beta-1 that is encoded in the genome of human.


olfactory nerve maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.


CO4A6_HUMAN Collagen alpha-6(IV) chain (sprot)

A collagen alpha-6(IV) chain that is encoded in the genome of human.


BAAT_HUMAN Bile acid-CoA:amino acid N-acyltransferase (sprot)

A bile acid-CoA:amino acid N-acyltransferase that is encoded in the genome of human.


glycine N-choloyltransferase activity

Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate.


very long chain acyl-CoA hydrolase activity

Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18.


bile acid conjugation

The process in which bile acids are covalently linked to taurine or glycine.


CO9A3_HUMAN Collagen alpha-3(IX) chain (sprot)

A collagen alpha-3(IX) chain that is encoded in the genome of human.


CO9A2_HUMAN Collagen alpha-2(IX) chain (sprot)

A collagen alpha-2(IX) chain that is encoded in the genome of human.


COX17_HUMAN Cytochrome c oxidase copper chaperone (sprot)

A cytochrome c oxidase copper chaperone that is encoded in the genome of human.


RB33A_HUMAN Ras-related protein Rab-33A (sprot)

A Ras-related protein Rab-33A that is encoded in the genome of human.


CYLC2_HUMAN Cylicin-2 (sprot)

A cylicin-2 that is encoded in the genome of human.


CCNI_HUMAN Cyclin-I (sprot)

A cyclin-I that is encoded in the genome of human.


HNRPD_HUMAN Heterogeneous nuclear ribonucleoprotein D0 (sprot)

A heterogeneous nuclear ribonucleoprotein D0 that is encoded in the genome of human.


cellular response to putrescine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus.


hepatocyte dedifferentiation

The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.


TOB2_HUMAN Protein Tob2 (sprot)

A protein Tob2 that is encoded in the genome of human.


SCRB2_HUMAN Lysosome membrane protein 2 (sprot)

A lysosome membrane protein 2 that is encoded in the genome of human.


aminophospholipid transport

The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group.


regulation of carbohydrate catabolic process

Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates.


regulation of lysosome organization

Any process that modulates the frequency, rate or extent of lysosome organization.


NID2_HUMAN Nidogen-2 (sprot)

A nidogen-2 that is encoded in the genome of human.


LRP8_HUMAN Low-density lipoprotein receptor-related protein 8 (sprot)

A low-density lipoprotein receptor-related protein 8 that is encoded in the genome of human.


ammon gyrus development

The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons.


IL18_HUMAN Interleukin-18 (sprot)

An interleukin-18 that is encoded in the genome of human.


interleukin-18 receptor binding

Binding to an interleukin-18 receptor.


DPYS_HUMAN Dihydropyrimidinase (sprot)

A dihydropyrimidinase that is encoded in the genome of human.


dihydropyrimidinase activity

Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.


DAG1_HUMAN Dystroglycan 1 (sprot)

A dystroglycan 1 that is encoded in the genome of human.


calcium-dependent cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction.


nerve maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.


retrograde trans-synaptic signaling by trans-synaptic protein complex

Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex.


VEZF1_HUMAN Vascular endothelial zinc finger 1 (sprot)

A vascular endothelial zinc finger 1 that is encoded in the genome of human.


PDE1C_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (sprot)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C that is encoded in the genome of human.


DSG2_HUMAN Desmoglein-2 (sprot)

A desmoglein-2 that is encoded in the genome of human.


DGCR6_HUMAN Protein DGCR6 (sprot)

A protein DGCR6 that is encoded in the genome of human.


TRI29_HUMAN Tripartite motif-containing protein 29 (sprot)

A tripartite motif-containing protein 29 that is encoded in the genome of human.


VGLL4_HUMAN Transcription cofactor vestigial-like protein 4 (sprot)

A transcription cofactor vestigial-like protein 4 that is encoded in the genome of human.


BOP1_HUMAN Ribosome biogenesis protein BOP1 (sprot)

A ribosome biogenesis protein BOP1 that is encoded in the genome of human.


cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


UBE4A_HUMAN Ubiquitin conjugation factor E4 A (sprot)

A ubiquitin conjugation factor E4 A that is encoded in the genome of human.


SRTD2_HUMAN SERTA domain-containing protein 2 (sprot)

A SERTA domain-containing protein 2 that is encoded in the genome of human.


SEPT6_HUMAN Septin-6 (sprot)

A septin-6 that is encoded in the genome of human.


septin collar

A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell.


TRI14_HUMAN Tripartite motif-containing protein 14 (sprot)

A tripartite motif-containing protein 14 that is encoded in the genome of human.


KEAP1_HUMAN Kelch-like ECH-associated protein 1 (sprot)

A kelch-like ECH-associated protein 1 that is encoded in the genome of human.


URB2_HUMAN Unhealthy ribosome biogenesis protein 2 homolog (sprot)

An unhealthy ribosome biogenesis protein 2 that is encoded in the genome of human.


DHX34_HUMAN Probable ATP-dependent RNA helicase DHX34 (sprot)

A probable ATP-dependent RNA helicase DHX34 that is encoded in the genome of human.


MORC3_HUMAN MORC family CW-type zinc finger protein 3 (sprot)

A MORC family CW-type zinc finger protein 3 that is encoded in the genome of human.


SAFB2_HUMAN Scaffold attachment factor B2 (sprot)

A scaffold attachment factor B2 that is encoded in the genome of human.


EIF3A_HUMAN Eukaryotic translation initiation factor 3 subunit A (sprot)

A eukaryotic translation initiation factor 3 subunit A that is encoded in the genome of human.


FA53B_HUMAN Protein FAM53B (sprot)

A protein FAM53B that is encoded in the genome of human.


DELE1_HUMAN DAP3-binding cell death enhancer 1 (sprot)

A DAP3-binding cell death enhancer 1 that is encoded in the genome of human.


response to iron ion starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.


ARHG7_HUMAN Rho guanine nucleotide exchange factor 7 (sprot)

A Rho guanine nucleotide exchange factor 7 that is encoded in the genome of human.


negative regulation of microtubule nucleation

Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation.


EFR3A_HUMAN Protein EFR3 homolog A (sprot)

A protein EFR3 homolog A that is encoded in the genome of human.


UBP2L_HUMAN Ubiquitin-associated protein 2-like (sprot)

A ubiquitin-associated protein 2-like that is encoded in the genome of human.


SPIDR_HUMAN DNA repair-scaffolding protein (sprot)

A DNA repair-scaffolding protein that is encoded in the genome of human.


regulation of establishment of protein localization to chromosome

Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome.


SCRIB_HUMAN Protein scribble homolog (sprot)

A protein LAP4 that is encoded in the genome of human.


GIT2_HUMAN ARF GTPase-activating protein GIT2 (sprot)

An ARF GTPase-activating protein GIT2 that is encoded in the genome of human.


SREC_HUMAN Scavenger receptor class F member 1 (sprot)

A scavenger receptor class F member 1 that is encoded in the genome of human.


IKKE_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit epsilon (sprot)

An inhibitor of nuclear factor kappa-B kinase subunit epsilon that is encoded in the genome of human.


MLEC_HUMAN Malectin (sprot)

A malectin that is encoded in the genome of human.


TTL12_HUMAN Tubulin--tyrosine ligase-like protein 12 (sprot)

A tubulin--tyrosine ligase-like protein 12 that is encoded in the genome of human.


tubulin-tyrosine ligase activity

Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.


histone H4K20 trimethyltransferase activity

Catalysis of the reaction: L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3.


MPP2_HUMAN MAGUK p55 subfamily member 2 (sprot)

A MAGUK p55 subfamily member 2 that is encoded in the genome of human.


DPOA2_HUMAN DNA polymerase alpha subunit B (sprot)

A DNA polymerase alpha subunit B that is encoded in the genome of human.


DOC2A_HUMAN Double C2-like domain-containing protein alpha (sprot)

A double C2-like domain-containing protein alpha that is encoded in the genome of human.


regulation of calcium ion-dependent exocytosis

Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.


DOC2B_HUMAN Double C2-like domain-containing protein beta (sprot)

A double C2-like domain-containing protein beta that is encoded in the genome of human.


DOCK1_HUMAN Dedicator of cytokinesis protein 1 (sprot)

A dedicator of cytokinesis protein 1 that is encoded in the genome of human.


TFDP1_HUMAN Transcription factor Dp-1 (sprot)

A transcription factor Dp-1 that is encoded in the genome of human.


TFDP2_HUMAN Transcription factor Dp-2 (sprot)

A transcription factor Dp-2 that is encoded in the genome of human.


SIM2_HUMAN Single-minded homolog 2 (sprot)

A single-minded homolog 2 that is encoded in the genome of human.


WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (sprot)

A bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN that is encoded in the genome of human.


3'-flap-structured DNA binding

Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule.


regulation of growth rate

Any process that modulates the rate of growth of all or part of an organism.


positive regulation of strand invasion

Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.


FHL2_HUMAN Four and a half LIM domains protein 2 (sprot)

A four and a half LIM domains protein 2 that is encoded in the genome of human.


DPYL1_HUMAN Dihydropyrimidinase-related protein 1 (sprot)

A dihydropyrimidinase-related protein 1 that is encoded in the genome of human.


negative regulation of actin filament binding

Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding.


DPYL3_HUMAN Dihydropyrimidinase-related protein 3 (sprot)

A dihydropyrimidinase-related protein 3 that is encoded in the genome of human.


ICT1_HUMAN Large ribosomal subunit protein mL62 (sprot)

An immature colon carcinoma transcript 1 protein that is encoded in the genome of human.


translation release factor activity, codon nonspecific

A translation release factor that is not specific to particular codons; binds to guanine nucleotides.


BTG3_HUMAN Protein BTG3 (sprot)

A protein BTG3 that is encoded in the genome of human.


ZMYM3_HUMAN Zinc finger MYM-type protein 3 (sprot)

A zinc finger MYM-type protein 3 that is encoded in the genome of human.


DCTN1_HUMAN Dynactin subunit 1 (sprot)

A dynactin subunit 1 that is encoded in the genome of human.


centriole-centriole cohesion

The cell cycle process in which the two centrioles within a centrosome remain tightly paired.


microtubule anchoring at centrosome

Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome.


positive regulation of neuromuscular junction development

Any process that activates or increases the frequency, rate or extent of neuromuscular junction development.


DYHC1_HUMAN Cytoplasmic dynein 1 heavy chain 1 (sprot)

A cytoplasmic dynein 1 heavy chain 1 that is encoded in the genome of human.


minus-end-directed microtubule motor activity

A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis.


positive regulation of intracellular transport

Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.


regulation of metaphase plate congression

Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.


RCAN2_HUMAN Calcipressin-2 (sprot)

A calcipressin-2 that is encoded in the genome of human.


NPAT_HUMAN Protein NPAT (sprot)

A protein NPAT that is encoded in the genome of human.


E2F2_HUMAN Transcription factor E2F2 (sprot)

A transcription factor E2F2 that is encoded in the genome of human.


LY6D_HUMAN Lymphocyte antigen 6D (sprot)

A lymphocyte antigen 6D that is encoded in the genome of human.


IL27B_HUMAN Interleukin-27 subunit beta (sprot)

An interleukin-27 subunit beta that is encoded in the genome of human.


interleukin-27 receptor binding

Binding to an interleukin-27 receptor.


EI2BA_HUMAN Translation initiation factor eIF-2B subunit alpha (sprot)

A translation initiation factor eIF-2B subunit alpha that is encoded in the genome of human.


EPAG_HUMAN Early lymphoid activation gene protein (sprot)

An early lymphoid activation gene protein that is encoded in the genome of human.


IF4A2_HUMAN Eukaryotic initiation factor 4A-II (sprot)

A eukaryotic initiation factor 4A-II that is encoded in the genome of human.


negative regulation of RNA-dependent RNA polymerase activity

Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity.


ELOA1_HUMAN Elongin-A (sprot)

An elongin-A that is encoded in the genome of human.


SELPL_HUMAN P-selectin glycoprotein ligand 1 (sprot)

A P-selectin glycoprotein ligand 1 that is encoded in the genome of human.


MAP7_HUMAN Ensconsin (sprot)

An ensconsin that is encoded in the genome of human.


AGRE1_HUMAN Adhesion G protein-coupled receptor E1 (sprot)

An adhesion G protein-coupled receptor E1 that is encoded in the genome of human.


SRC8_HUMAN Src substrate cortactin (sprot)

A Src substrate cortactin that is encoded in the genome of human.


lamellipodium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.


NUCG_HUMAN Endonuclease G, mitochondrial (sprot)

An endonuclease G, mitochondrial that is encoded in the genome of human.


mitochondrial DNA catabolic process

The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA.


FLOT2_HUMAN Flotillin-2 (sprot)

A flotillin-2 that is encoded in the genome of human.


anterograde dendritic transport

The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites.


RCN2_HUMAN Reticulocalbin-2 (sprot)

A reticulocalbin-2 that is encoded in the genome of human.


TRI25_HUMAN E3 ubiquitin/ISG15 ligase TRIM25 (sprot)

An E3 ubiquitin/ISG15 ligase TRIM25 that is encoded in the genome of human.


RIG-I binding

Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.


regulation of viral entry into host cell

Any process that modulates the frequency, rate or extent of the viral entry into the host cell.


ENR1_HUMAN Endogenous retrovirus group 3 member 1 Env polyprotein (sprot)

An endogenous retrovirus group 3 member 1 Env polyprotein that is encoded in the genome of human.


FAK2_HUMAN Protein-tyrosine kinase 2-beta (sprot)

A focal adhesion kinase 2 that is encoded in the genome of human.


3-phosphoinositide-dependent protein kinase binding

Binding to a 3-phosphoinositide-dependent protein kinase.


regulation of macrophage chemotaxis

Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.


response to cation stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment.


FASTK_HUMAN Fas-activated serine/threonine kinase (sprot)

A Fas-activated serine/threonine kinase that is encoded in the genome of human.


Fas-activated serine/threonine kinase activity

Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein.


FGL2_HUMAN Fibroleukin (sprot)

A fibroleukin that is encoded in the genome of human.


negative regulation of macrophage antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.


negative regulation of memory T cell differentiation

Any process that stops, prevents, or reduces the rate of memory T cell differentiation.


FLNC_HUMAN Filamin-C (sprot)

A filamin-C that is encoded in the genome of human.


FKBP8_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP8 (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP8 that is encoded in the genome of human.


FA50A_HUMAN Protein FAM50A (sprot)

A protein FAM50A that is encoded in the genome of human.


MYPC2_HUMAN Myosin-binding protein C, fast-type (sprot)

A myosin-binding protein C, fast-type that is encoded in the genome of human.


GPR18_HUMAN N-arachidonyl glycine receptor (sprot)

An N-arachidonyl glycine receptor that is encoded in the genome of human.


CD8-positive, alpha-beta intraepithelial T cell differentiation

The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.


FRG1_HUMAN Protein FRG1 (sprot)

A protein FRG1 that is encoded in the genome of human.


FZD2_HUMAN Frizzled-2 (sprot)

A frizzled-2 that is encoded in the genome of human.


GNA13_HUMAN Guanine nucleotide-binding protein subunit alpha-13 (sprot)

A guanine nucleotide-binding protein subunit alpha-13 that is encoded in the genome of human.


GAMT_HUMAN Guanidinoacetate N-methyltransferase (sprot)

A guanidinoacetate N-methyltransferase that is encoded in the genome of human.


Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H+.


GALE_HUMAN UDP-glucose 4-epimerase (sprot)

A UDP-glucose 4-epimerase that is encoded in the genome of human.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.


UDP-glucose 4-epimerase activity

Catalysis of the reaction: UDP-glucose = UDP-galactose.


GGTL2_HUMAN Glutathione hydrolase light chain 2 (sprot)

A glutathione hydrolase light chain 2 that is encoded in the genome of human.


LRC32_HUMAN Transforming growth factor beta activator LRRC32 (sprot)

A transforming growth factor beta activator LRRC32 that is encoded in the genome of human.


regulation of transforming growth factor beta3 activation

Any process that modulates the frequency, rate or extent of transforming growth factor beta3 activation.


GAS6_HUMAN Growth arrest-specific protein 6 (sprot)

A growth arrest-specific protein 6 that is encoded in the genome of human.


cellular response to vitamin K

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus.


negative regulation of oligodendrocyte apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process.


negative regulation of renal albumin absorption

Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption.


GCKR_HUMAN Glucokinase regulatory protein (sprot)

A glucokinase regulatory protein that is encoded in the genome of human.


carbohydrate derivative metabolic process

The chemical reactions and pathways involving carbohydrate derivative.


CSHL_HUMAN Chorionic somatomammotropin hormone-like 1 (sprot)

A chorionic somatomammotropin hormone-like 1 that is encoded in the genome of human.


GLPK3_HUMAN Glycerol kinase 3 (sprot)

A glycerol kinase 3 that is encoded in the genome of human.


GLPK2_HUMAN Glycerol kinase 2 (sprot)

A glycerol kinase 2 that is encoded in the genome of human.


sperm mitochondrial sheath assembly

The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.


GRM2_HUMAN Metabotropic glutamate receptor 2 (sprot)

A metabotropic glutamate receptor 2 that is encoded in the genome of human.


regulation of response to drug

Any process that modulates the frequency, rate or extent of response to drug.