NUMBL_HUMAN Numb-like protein (sprot)

A Numb-like protein that is encoded in the genome of human.


S4A4_HUMAN Electrogenic sodium bicarbonate cotransporter 1 (sprot)

An electrogenic sodium bicarbonate cotransporter 1 that is encoded in the genome of human.


M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (sprot)

A mitogen-activated protein kinase kinase kinase 4 that is encoded in the genome of human.


Z780B_HUMAN Zinc finger protein 780B (sprot)

A zinc finger protein 780B that is encoded in the genome of human.


FCGBP_HUMAN IgGFc-binding protein (sprot)

An IgGFc-binding protein that is encoded in the genome of human.


CCD61_HUMAN Centrosomal protein CCDC61 (sprot)

A centrosomal protein CCDC61 that is encoded in the genome of human.


RPKL1_HUMAN Ribosomal protein S6 kinase-like 1 (sprot)

A ribosomal protein S6 kinase-like 1 that is encoded in the genome of human.


DGKB_HUMAN Diacylglycerol kinase beta (sprot)

A diacylglycerol kinase beta that is encoded in the genome of human.


SCIN_HUMAN Scinderin (sprot)

A scinderin that is encoded in the genome of human.


RN215_HUMAN RING finger protein 215 (sprot)

A RING finger protein 215 that is encoded in the genome of human.


PCLO_HUMAN Protein piccolo (sprot)

A protein piccolo that is encoded in the genome of human.


DDX49_HUMAN Probable ATP-dependent RNA helicase DDX49 (sprot)

A probable ATP-dependent RNA helicase DDX49 that is encoded in the genome of human.


regulation of rRNA stability

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs.


CAN7_HUMAN Calpain-7 (sprot)

A calpain-7 that is encoded in the genome of human.


WASF2_HUMAN Actin-binding protein WASF2 (sprot)

An actin-binding protein WASF2 that is encoded in the genome of human.


DUS10_HUMAN Dual specificity protein phosphatase 10 (sprot)

A dual specificity protein phosphatase 10 that is encoded in the genome of human.


negative regulation of epithelium regeneration

Any process that stops, prevents or reduces the frequency, rate or extent of epithelium regeneration.


ICOS_HUMAN Inducible T-cell costimulator (sprot)

An inducible T-cell costimulator that is encoded in the genome of human.


SETBP_HUMAN SET-binding protein (sprot)

A SET-binding protein that is encoded in the genome of human.


SERP1_HUMAN Stress-associated endoplasmic reticulum protein 1 (sprot)

A stress-associated endoplasmic reticulum protein 1 that is encoded in the genome of human.


PIAS3_HUMAN E3 SUMO-protein ligase PIAS3 (sprot)

An E3 SUMO-protein ligase PIAS3 that is encoded in the genome of human.


SCC4_HUMAN MAU2 chromatid cohesion factor homolog (sprot)

A MAU2 chromatid cohesion factor homolog that is encoded in the genome of human.


F169A_HUMAN Soluble lamin-associated protein of 75 kDa (sprot)

A soluble lamin-associated protein of 75 kDa that is encoded in the genome of human.


ENPP4_HUMAN Bis(5'-adenosyl)-triphosphatase ENPP4 (sprot)

A bis(5'-adenosyl)-triphosphatase ENPP4 that is encoded in the genome of human.


purine ribonucleoside catabolic process

The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.


MYO16_HUMAN Unconventional myosin-XVI (sprot)

A myosin-XVI that is encoded in the genome of human.


ZHX2_HUMAN Zinc fingers and homeoboxes protein 2 (sprot)

A zinc fingers and homeoboxes protein 2 that is encoded in the genome of human.


MORC2_HUMAN ATPase MORC2 (sprot)

An ATPase MORC2 that is encoded in the genome of human.


NS1BP_HUMAN Influenza virus NS1A-binding protein (sprot)

An influenza virus NS1A-binding protein that is encoded in the genome of human.


CMTA1_HUMAN Calmodulin-binding transcription activator 1 (sprot)

A calmodulin-binding transcription activator 1 that is encoded in the genome of human.


S23IP_HUMAN SEC23-interacting protein (sprot)

A SEC23-interacting protein that is encoded in the genome of human.


LY96_HUMAN Lymphocyte antigen 96 (sprot)

A lymphocyte antigen 96 that is encoded in the genome of human.


CF123_HUMAN Uncharacterized protein encoded by LINC01558 (sprot)

A protein that is a translation product of the LINC01558 gene in human.


KIAS1_HUMAN Putative uncharacterized protein KIF25-AS1 (sprot)


AFDDT_HUMAN Putative uncharacterized protein AFDN-DT (sprot)


COL10_HUMAN Collectin-10 (sprot)

A collectin-10 that is encoded in the genome of human.


HMN13_HUMAN Humanin-like 13 (sprot)

A protein that is a translation product of the MTRNR2L13 gene in human.


HMN11_HUMAN Humanin-like 11 (sprot)

A protein that is a translation product of the MTRNR2L11 gene in human.


A3LT2_HUMAN Alpha-1,3-galactosyltransferase 2 (sprot)

An alpha-1,3-galactosyltransferase 2 that is encoded in the genome of human.


biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP.


V9GZ13_HUMAN MKKS centrosomal shuttling protein (trembl)


SACA6_HUMAN Sperm acrosome membrane-associated protein 6 (sprot)

A sperm acrosome membrane-associated protein 6 that is encoded in the genome of human.


PYDC5_HUMAN Pyrin domain-containing protein 5 (sprot)

A protein that is a translation product of the PYDC5 gene in human.


A0A075B7E8_HUMAN Immunoglobulin heavy variable 3/OR16-13 (non-functional) (Fragment) (trembl)


deoxynucleoside kinase activity

Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate.


animal organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


urotensin II receptor activity

Combining with urotensin II to initiate a change in cell activity.


GOG6D_HUMAN Golgin subfamily A member 6D (sprot)

A protein that is a translation product of the GOLGA6D gene in human.


CA5BL_HUMAN Putative inactive carbonic anhydrase 5B-like protein (sprot)


KAL1L_HUMAN KAT8 regulatory NSL complex subunit 1-like protein (sprot)

A KAT8 regulatory NSL complex subunit 1-like protein that is encoded in the genome of human.


RRP7B_HUMAN Putative ribosomal RNA-processing protein 7 homolog B (sprot)


3'-tRNA processing endoribonuclease activity

Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.


SERP3_HUMAN Serpin E3 (sprot)

A serpin E3 that is encoded in the genome of human.


postsynaptic early endosome

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.


spindle elongation

The cell cycle process in which the distance is lengthened between poles of the spindle.


RMXL2_HUMAN RNA-binding motif protein, X-linked-like-2 (sprot)

An RNA-binding motif protein, X-linked-like-2 that is encoded in the genome of human.


CF052_HUMAN Putative uncharacterized protein C6orf52 (sprot)

A protein that is a translation product of the C6orf52 gene in human.


transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.


SAM14_HUMAN Sterile alpha motif domain-containing protein 14 (sprot)

A sterile alpha motif domain-containing protein 14 that is encoded in the genome of human.


U4 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U4 snRNA molecule.


CEA21_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 21 (sprot)

A carcinoembryonic antigen-related cell adhesion molecule 21 that is encoded in the genome of human.


histone H4 deacetylation

The modification of histone H4 by the removal of one or more acetyl groups.


GOG6B_HUMAN Golgin subfamily A member 6B (sprot)

A protein that is a translation product of the GOLGA6B gene in human.


snRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.


nucleophagy

A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded.


SEM3D_HUMAN Semaphorin-3D (sprot)

A semaphorin-3D that is encoded in the genome of human.


The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate.


piecemeal microautophagy of the nucleus

Degradation of a cell nucleus by lysosomal microautophagy.


A0A075B7D0_HUMAN Immunoglobulin heavy variable 1/OR15-1 (non-functional) (Fragment) (trembl)


rRNA acetylation involved in maturation of SSU-rRNA

Any rRNA acetylation that is involved in maturation of SSU-rRNA.


septin ring organization

Control of the formation, spatial distribution, and breakdown of the septin ring.


GOG8Q_HUMAN Golgin subfamily A member 8Q (sprot)

A protein that is a translation product of the GOLGA8Q gene in human.


transport

The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.


LR75A_HUMAN Leucine-rich repeat-containing protein 75A (sprot)

A leucine-rich repeat-containing protein 75A that is encoded in the genome of human.


nuclear polyadenylation-dependent tRNA catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA.


TSNA1_HUMAN t-SNARE domain-containing protein 1 (sprot)

A t-SNARE domain-containing protein 1 that is encoded in the genome of human.


anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.


ARRD5_HUMAN Arrestin domain-containing protein 5 (sprot)

An arrestin domain-containing protein 5 that is encoded in the genome of human.


RN3P2_HUMAN Putative RRN3-like protein RRN3P2 (sprot)


PDZ1P_HUMAN Putative PDZ domain-containing protein PDZK1P1 (sprot)


maintenance of ER location

Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere.


thiosulfate transport

The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


UFM1 transferase activity

Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages.


TM88B_HUMAN Transmembrane protein 88B (sprot)

A transmembrane protein 88B that is encoded in the genome of human.


tRNA metabolic process

The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.


maturation of LSU-rRNA

Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.


detoxification of zinc ion

Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion.


plasmacytoid dendritic cell cytokine production

Any process that contributes to cytokine production by a plasmacytoid dendritic cell.


late endosome to vacuole transport via multivesicular body sorting pathway

The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole.


HNRC3_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 3 (sprot)

A protein that is a translation product of the HNRNPCL3 gene in human.


RNA polymerase I complex

RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.


Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA.


hemoglobin alpha binding

Binding to a hemoglobin alpha chain.


SH2D7_HUMAN SH2 domain-containing protein 7 (sprot)

An SH2 domain-containing protein 7 that is encoded in the genome of human.


SPD8_HUMAN Putative speedy protein E8 (sprot)


monosaccharide transmembrane transport

The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


lipid kinase activity

Catalysis of the phosphorylation of a simple or complex lipid.


GBG14_HUMAN Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 (sprot)


NBEL1_HUMAN Neurobeachin-like protein 1 (sprot)

A neurobeachin-like protein 1 that is encoded in the genome of human.


meiotic DNA integrity checkpoint signaling

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.


neurotransmitter receptor transport, postsynaptic endosome to lysosome

The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.


type 2 orexin receptor binding

Binding to a type 2 orexin receptor.


SAM10_HUMAN Sterile alpha motif domain-containing protein 10 (sprot)

A sterile alpha motif domain-containing protein 10 that is encoded in the genome of human.


TBC12_HUMAN TBC1 domain family member 12 (sprot)

A TBC1 domain family member 12 that is encoded in the genome of human.


A0A0C4DH90_HUMAN Immunoglobulin kappa variable 3/OR2-268 (non-functional) (Fragment) (trembl)


immunoglobulin production

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


propionate catabolic process

The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid.


snoRNA splicing

The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA.


Ssh1 translocon complex

A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences.


embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.


OSER1_HUMAN Oxidative stress-responsive serine-rich protein 1 (sprot)

An oxidative stress-responsive serine-rich protein 1 that is encoded in the genome of human.


MANS4_HUMAN MANSC domain-containing protein 4 (sprot)

A MANSC domain-containing protein 4 that is encoded in the genome of human.


CTGE8_HUMAN cTAGE family member 8 (sprot)

A cTAGE family member 8 that is encoded in the genome of human.


post-mRNA release spliceosomal complex

A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac.


D-tyrosyl-tRNA(Tyr) deacylase activity

Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA.


DNA recombinase auxiliary factor complex

A protein complex that binds to a recombinase and incrseases its activity.


MAGB1_HUMAN Melanoma-associated antigen B1 (sprot)

A melanoma-associated antigen B1 that is encoded in the genome of human.


homogentisate catabolic process

The chemical reactions and pathways resulting in the breakdown of homogentisate.


CLBA1_HUMAN Uncharacterized protein CLBA1 (sprot)

An uncharacterized protein CLBA1 that is encoded in the genome of human.


UBA1L_HUMAN Ubiquitin-associated protein 1-like (sprot)

A ubiquitin-associated protein 1-like that is encoded in the genome of human.


CPHL2_HUMAN Cytoplasmic polyadenylated homeobox-like protein 2 (sprot)

A protein that is a translation product of the CPHXL2 gene in human.


Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor.


A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces.


double-strand break repair via break-induced replication

The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.


RNA transmembrane transporter activity

Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.


MOXD2_HUMAN Putative DBH-like monooxygenase protein 2 (sprot)


MAP kinase tyrosine phosphatase activity

Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate.


kainate selective glutamate receptor complex

An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits.


intracellular anatomical structure

A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.


fatty-acyl-CoA synthase activity

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.


CRGN_HUMAN Gamma-crystallin N (sprot)

A gamma-crystallin N that is encoded in the genome of human.


M4A15_HUMAN Membrane-spanning 4-domains subfamily A member 15 (sprot)

A membrane-spanning 4-domains subfamily A member 15 that is encoded in the genome of human.


exocyst localization

Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.


CAN13_HUMAN Calpain-13 (sprot)

A calpain-13 that is encoded in the genome of human.


CURI complex

A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.


Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.


single-strand break-containing DNA binding

Binding to damaged DNA containing single-strand breaks (SSBs).


perturbation of plasma membrane integrity in another organism

The disruption of the cell membrane of another organism, leading to damage or temporary subversion of the membrane.


intracellular cyclic nucleotide activated cation channel complex

A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts.


UTP-C complex

A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p.


A0A2R8Y5M8_HUMAN Transmembrane O-methyltransferase (trembl)


synaptic signaling

Cell-cell signaling to, from or within a synapse.


inositol tetrakisphosphate kinase activity

Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP.


D19L4_HUMAN Probable C-mannosyltransferase DPY19L4 (sprot)

A protein dpy-19 4 that is encoded in the genome of human.


Lsm1-7-Pat1 complex

A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway.


tRNA-specific adenosine-34 deaminase activity

Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule.


DC4L2_HUMAN DDB1- and CUL4-associated factor 4-like protein 2 (sprot)

A DDB1- and CUL4-associated factor 4-like protein 2 that is encoded in the genome of human.


LITAD_HUMAN LITAF domain-containing protein (sprot)


GOG8M_HUMAN Golgin subfamily A member 8M (sprot)

A protein that is a translation product of the GOLGA8M gene in human.


regulation of ER-associated ubiquitin-dependent protein catabolic process

Any process that modulates the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process.


ANHX_HUMAN Anomalous homeobox protein (sprot)

An anomalous homeobox protein that is encoded in the genome of human.


PAL4C_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4C (sprot)

A protein that is a translation product of the PPIAL4C gene in human.


Rad6-Rad18 complex

A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity.


Sm-like protein family complex

A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles.


quinolinate metabolic process

The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.


negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly

Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly.


SHSA8_HUMAN Protein shisa-8 (sprot)

A protein shisa-8 that is encoded in the genome of human.


acylphosphatase activity

Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.


histone ubiquitination

The modification of histones by addition of ubiquitin groups.


K1614_HUMAN Uncharacterized protein KIAA1614 (sprot)

A protein that is a translation product of the KIAA1614 gene in human.


MutLalpha complex

A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.


structural constituent of postsynaptic intermediate filament cytoskeleton

The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton.


CLUL1_HUMAN Clusterin-like protein 1 (sprot)

A clusterin-like protein 1 that is encoded in the genome of human.


histone H3-R26 methylation

The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone.


positive regulation of G2/MI transition of meiotic cell cycle

Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.


MAGC3_HUMAN Melanoma-associated antigen C3 (sprot)

A melanoma-associated antigen C3 that is encoded in the genome of human.


exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.


HDGL1_HUMAN Hepatoma-derived growth factor-like protein 1 (sprot)

A hepatoma-derived growth factor-like protein 1 that is encoded in the genome of human.


VWDE_HUMAN von Willebrand factor D and EGF domain-containing protein (sprot)

A von Willebrand factor D and EGF domain-containing protein that is encoded in the genome of human.


thyrotropin-releasing hormone receptor activity

Combining with thyrotropin-releasing hormone to initiate a change in cell activity.


septin ring

A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form.


MRFL_HUMAN Myelin regulatory factor-like protein (sprot)

A myelin regulatory factor-like protein that is encoded in the genome of human.


SH2D6_HUMAN SH2 domain-containing protein 6 (sprot)

An SH2 domain-containing protein 6 that is encoded in the genome of human.


Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide.


NKG2F_HUMAN NKG2-F type II integral membrane protein (sprot)

An NKG2-F type II integral membrane protein that is encoded in the genome of human.


adenosine 5'-(hexahydrogen pentaphosphate) catabolic process

The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate).


nuclear microtubule

Any microtubule in the nucleus of a cell.


Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate.


immunoglobulin production involved in immunoglobulin-mediated immune response

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.


establishment of cell polarity involved in ameboidal cell migration

The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.


T11X1_HUMAN T-complex protein 11 X-linked protein 1 (sprot)

A protein that is a translation product of the TCP11X1 gene in human.


spine apparatus assembly

The aggregation, arrangement and bonding together of a set of components to form a spine apparatus.


RAB42_HUMAN Ras-related protein Rab-42 (sprot)

A Ras-related protein Rab-42 that is encoded in the genome of human.


SP201_HUMAN Transcription factor SPT20 homolog-like 1 (sprot)

A protein FAM48B1 that is encoded in the genome of human.


DPPA5_HUMAN Developmental pluripotency-associated 5 protein (sprot)

A developmental pluripotency-associated 5 protein that is encoded in the genome of human.


ANKF1_HUMAN Ankyrin repeat and fibronectin type-III domain-containing protein 1 (sprot)

An ankyrin repeat and fibronectin type-III domain-containing protein 1 that is encoded in the genome of human.


The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


histone H4 acetylation

The modification of histone H4 by the addition of an acetyl group.


prolactin-releasing peptide receptor binding

Binding to a prolactin-releasing peptide receptor.


regulation of ERBB signaling pathway

Any process that modulates the frequency, rate or extent of ERBB signaling pathway.


HIR complex

A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p.


CCR4-NOT core complex

The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.


GOG8H_HUMAN Golgin subfamily A member 8H (sprot)

A golgin subfamily A member 8H that is encoded in the genome of human.


PLS5_HUMAN Phospholipid scramblase family member 5 (sprot)

A phospholipid scramblase family member 5 that is encoded in the genome of human.


PDCL2_HUMAN Phosducin-like protein 2 (sprot)

A phosducin-like protein 2 that is encoded in the genome of human.


phosphatidylinositol 3-kinase complex, class III, type I

A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.


inhibitory extracellular ligand-gated monoatomic ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.


actin-based cell projection

A cell projection supported by an assembly of actin filaments, and which lacks microtubules.


LRC58_HUMAN Leucine-rich repeat-containing protein 58 (sprot)

A leucine-rich repeat-containing protein 58 that is encoded in the genome of human.


LRC43_HUMAN Leucine-rich repeat-containing protein 43 (sprot)

A leucine-rich repeat-containing protein 43 that is encoded in the genome of human.


IQCF6_HUMAN IQ domain-containing protein F6 (sprot)

A protein that is a translation product of the IQCF6 gene in human.


peroxisomal importomer complex

A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners.


D19P2_HUMAN Putative C-mannosyltransferase DPY19L2P2 (sprot)

A protein dpy-19 2-like 2 that is encoded in the genome of human.


GOG8C_HUMAN Golgin subfamily A member 8C (sprot)


phosphocreatine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase.


K1755_HUMAN Uncharacterized protein KIAA1755 (sprot)

An uncharacterized protein KIAA1755 that is encoded in the genome of human.


UBE3B_HUMAN Ubiquitin-protein ligase E3B (sprot)

A ubiquitin-protein ligase E3B that is encoded in the genome of human.


D-xylose 1-dehydrogenase (NADP+) activity

Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + H+ + NADPH.


Ral protein signal transduction

The series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.


PYY3_HUMAN Putative peptide YY-3 (sprot)


synapse assembly involved in innervation

The assembly of a synapse within a target tissue in which a nerve is invading.


deoxyribonuclease II activity

Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products.


CCYL3_HUMAN Putative cyclin-Y-like protein 3 (sprot)

A putative cyclin-Y-like protein 3 that is encoded in the genome of human.


generation of catalytic spliceosome for second transesterification step

Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing.


M4A18_HUMAN Membrane-spanning 4-domains subfamily A member 18 (sprot)

A membrane-spanning 4-domains subfamily A member 18 that is encoded in the genome of human.


NAD salvage

Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam).


neuromedin B receptor binding

Binding to a neuromedin B receptor.


amino acid kinase activity

Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate.


proton-transporting ATP synthase complex, catalytic core F(1)

The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.


DUXB_HUMAN Double homeobox protein B (sprot)

A protein that is a translation product of the DUXB gene in human.


tRNA re-export from nucleus

The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export.


SIRB2_HUMAN Signal-regulatory protein beta-2 (sprot)

A signal-regulatory protein beta-2 that is encoded in the genome of human.


JUN kinase phosphatase activity

Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.


mitochondrial seryl-tRNA aminoacylation

The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


malonate-semialdehyde dehydrogenase (acetylating) activity

Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+.


regulation of recycling endosome localization within postsynapse

Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.


UBP41_HUMAN Putative ubiquitin carboxyl-terminal hydrolase 41 (sprot)

A putative ubiquitin carboxyl-terminal hydrolase 41 that is encoded in the genome of human.


PRS47_HUMAN Putative serine protease 47 (sprot)


EX3L4_HUMAN Exocyst complex component 3-like protein 4 (sprot)

An exocyst complex component 3-like protein 4 that is encoded in the genome of human.


sarcosine dehydrogenase activity

Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.


SNG4_HUMAN Synaptogyrin-4 (sprot)

A synaptogyrin-4 that is encoded in the genome of human.


pristanoyl-CoA oxidase activity

Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide.


histone H4-K16 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.


response to oxygen levels

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.


histone H3-K4 methylation

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.


PAL4H_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4H (sprot)

A protein that is a translation product of the PPIAL4H gene in human.


TM14E_HUMAN Transmembrane protein 14EP (sprot)

A transmembrane protein 14EP that is encoded in the genome of human.


RA1L3_HUMAN Heterogeneous nuclear ribonucleoprotein A1-like 3 (sprot)

A protein that is a translation product of the HNRNPA1L3 gene in human.


TM14D_HUMAN Transmembrane protein 14DP (sprot)

A transmembrane protein 14DP that is encoded in the genome of human.


RNA polymerase III activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


glycine receptor clustering

The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane.


MFS6L_HUMAN Major facilitator superfamily domain-containing protein 6-like (sprot)

A major facilitator superfamily domain-containing protein 6-like that is encoded in the genome of human.


sucrose biosynthetic process

The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside.


Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate.


regulation of arginine metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


PTG3L_HUMAN Putative protein PTGES3L (sprot)

A protein PTGES3L that is encoded in the genome of human.


cytokine production involved in immune response

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.


MB3LB_HUMAN Methyl-CpG-binding domain protein 3-like 2B (sprot)

A protein that is a translation product of the MBD3L2B gene in human.


Set3 complex

A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.


histone H2A acetylation

The modification of histone H2A by the addition of an acetyl group.


mu-type opioid receptor binding

Binding to a mu-type opioid receptor.


3'-nucleotidase activity

Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.


SMTL2_HUMAN Smoothelin-like protein 2 (sprot)

A smoothelin-like protein 2 that is encoded in the genome of human.


Pwp2p-containing subcomplex of 90S preribosome

A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.


XKR9_HUMAN XK-related protein 9 (sprot)

An XK-related protein 9 that is encoded in the genome of human.


IT70A_HUMAN Intraflagellar transport protein 70A (sprot)

A tetratricopeptide repeat protein 30A that is encoded in the genome of human.


histone H2A-K119 monoubiquitination

The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.


acetolactate synthase activity

Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.


calcium activated phospholipid scrambling

The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.


positive regulation of mitotic recombination

Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis.


M1BL1_HUMAN Metallothionein 1H-like protein 1 (sprot)

A protein that is a translation product of the MT1HL1 gene in human.


valine biosynthetic process

The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.


nuclear pore central transport channel

The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.


endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.


diadenosine pentaphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate.


GOG6C_HUMAN Golgin subfamily A member 6C (sprot)

A protein that is a translation product of the GOLGA6C gene in human.


immunoglobulin complex, circulating

An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.


positive regulation of heart rate by epinephrine-norepinephrine

The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.


NALF2_HUMAN NALCN channel auxiliary factor 2 (sprot)

A NALCN channel auxiliary factor 2 that is encoded in the genome of human.


A1 adenosine receptor binding

Binding to an A1 adenosine receptor.


GOG8N_HUMAN Golgin subfamily A member 8N (sprot)

A protein that is a translation product of the GOLGA8N gene in human.


carotenoid dioxygenase activity

Catalysis of the oxidative cleavage of carotenoids.


oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water.


A0A0G2JLQ3_HUMAN Killer cell immunoglobulin-like receptor (trembl)


Gtr1-Gtr2 GTPase complex

A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins.


lysine biosynthetic process via aminoadipic acid

The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.


RHN2P_HUMAN Putative rhophilin-2-like protein RHPN2P1 (sprot)


GID complex

A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species.


STPG3_HUMAN Protein STPG3 (sprot)

A protein STPG3 that is encoded in the genome of human.


Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.


plasma membrane signaling receptor complex

Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.


regulatory ncRNA-mediated heterochromatin formation

A heterochromatin formation-based gene silencing process mediated by a regulatory non-coding RNA molecule that occur before the beginnning of trancription.


PRS48_HUMAN Serine protease 48 (sprot)

A serine protease 48 that is encoded in the genome of human.


substance K receptor activity

Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity.


TRC complex

A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane.


Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.


A0A1W2PN81_HUMAN Neuronal acetylcholine receptor subunit alpha-7 (trembl)


acid-amino acid ligase activity

Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.


clathrin-dependent synaptic vesicle endocytosis

Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds.


P3URF_HUMAN PIK3R3 upstream open reading frame protein (sprot)

A PIK3R3 upstream open reading frame protein that is encoded in the genome of human.


protein O-GlcNAcylation via threonine

The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine.


AN34A_HUMAN Ankyrin repeat domain-containing protein 34A (sprot)

An ankyrin repeat domain-containing protein 34A that is encoded in the genome of human.


CTGEF_HUMAN cTAGE family member 15 (sprot)

A protein that is a translation product of the CTAGE15 gene in human.


K1522_HUMAN Uncharacterized protein KIAA1522 (sprot)

An uncharacterized protein KIAA1522 that is encoded in the genome of human.


farnesyl diphosphate biosynthetic process, mevalonate pathway

The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols.


GOG8T_HUMAN Golgin subfamily A member 8T (sprot)

A protein that is a translation product of the GOLGA8T gene in human.


P12L2_HUMAN POM121-like protein 2 (sprot)

A POM121-like protein 2 that is encoded in the genome of human.


glutathione-disulfide reductase (NADP) activity

Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.


nucleotide-excision repair factor 3 complex

One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p).


A0A0G2JP03_HUMAN Killer cell immunoglobulin-like receptor 3DL3 (Fragment) (trembl)


dUTP catabolic process

The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate.


mitotic G1 phase

The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.


SYT15_HUMAN Synaptotagmin-15 (sprot)

A synaptotagmin-15 that is encoded in the genome of human.


pyrimidine nucleobase biosynthetic process

The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


histone H3-K27 demethylation

The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.


actin filament debranching

An actin filament severing process that results in the removal of actin filament branches specifically at the branch points.


sodium-dependent multivitamin transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate.


T11X2_HUMAN T-complex protein 11 X-linked protein 2 (sprot)

A protein that is a translation product of the TCP11X2 gene in human.


nuclear polyadenylation-dependent snoRNA catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA.


ribose phosphate diphosphokinase complex

A protein complex having ribose phosphate diphosphokinase activity.


negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning

Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord.


ASTRA complex

A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p.


L-threonine ammonia-lyase activity

Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.


ACBD4_HUMAN Acyl-CoA-binding domain-containing protein 4 (sprot)

An acyl-CoA-binding domain-containing protein 4 that is encoded in the genome of human.


FKB1C_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1C (sprot)


squalene synthase activity

Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate.


histone monoubiquitination

The modification of histones by addition of a single ubiquitin group.


FR1L4_HUMAN Fer-1-like protein 4 (sprot)

A Fer-1-like protein 4 that is encoded in the genome of human.


norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.


OCEL1_HUMAN Occludin/ELL domain-containing protein 1 (sprot)

An occludin/ELL domain-containing protein 1 that is encoded in the genome of human.


MDH1B_HUMAN Putative malate dehydrogenase 1B (sprot)

A putative malate dehydrogenase 1B that is encoded in the genome of human.


DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates

Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA).


GRTP1_HUMAN Growth hormone-regulated TBC protein 1 (sprot)

A growth hormone-regulated TBC protein 1 that is encoded in the genome of human.


S-formylglutathione hydrolase activity

Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+.


FA53A_HUMAN Protein FAM53A (sprot)

A protein FAM53A that is encoded in the genome of human.


spliceosomal tri-snRNP complex

A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP.


CAST3_HUMAN Putative protein CASTOR3P (sprot)


leukotriene B4 receptor activity

Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.


PRS54_HUMAN Inactive serine protease 54 (sprot)

An inactive serine protease 54 that is encoded in the genome of human.


histone H4-K5 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.


DNA methylation on cytosine

The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule.


cellular response to nitrogen starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen.


LRC63_HUMAN Leucine-rich repeat-containing protein 63 (sprot)

A leucine-rich repeat-containing protein 63 that is encoded in the genome of human.


positive regulation of anaphase-promoting complex-dependent catabolic process

Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


KNCN_HUMAN Kinocilin (sprot)

A kinocilin that is encoded in the genome of human.


OLFL1_HUMAN Olfactomedin-like protein 1 (sprot)

An olfactomedin-like protein 1 that is encoded in the genome of human.


F135B_HUMAN Protein FAM135B (sprot)

A protein FAM135B that is encoded in the genome of human.


SATL1_HUMAN Spermidine/spermine N(1)-acetyltransferase-like protein 1 (sprot)

A spermidine/spermine N(1)-acetyltransferase-like protein 1 that is encoded in the genome of human.


spermidine binding

Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane.


A0A075B7D4_HUMAN Immunoglobulin kappa variable 1/OR2-108 (non-functional) (Fragment) (trembl)


RGPD1_HUMAN RANBP2-like and GRIP domain-containing protein 1 (sprot)

A RANBP2-like and GRIP domain-containing protein 1 that is encoded in the genome of human.


double-strand break repair via single-strand annealing

Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.


soluble NSF attachment protein activity

Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex.


diphosphoinositol polyphosphate metabolic process

The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached.


RGPD5_HUMAN RANBP2-like and GRIP domain-containing protein 5/6 (sprot)

A RANBP2-like and GRIP domain-containing protein 5/6 that is encoded in the genome of human.


ARH38_HUMAN Rho guanine nucleotide exchange factor 38 (sprot)

A Rho guanine nucleotide exchange factor 38 that is encoded in the genome of human.


retrograde trans-synaptic signaling by nitric oxide

Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.


post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery

The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.


deoxyribonuclease I activity

Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products.


ubiquitin-dependent protein catabolic process via the N-end rule pathway

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.


gonadotropin-releasing hormone receptor activity

Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


AN34C_HUMAN Ankyrin repeat domain-containing protein 34C (sprot)

An ankyrin repeat domain-containing protein 34C that is encoded in the genome of human.


neurotransmitter receptor transport postsynaptic membrane to endosome

Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome.


equatorial microtubule organizing center

A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.


succinate-CoA ligase complex

A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP.


regulation of postsynaptic neurotransmitter receptor activity

Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.


recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex

The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript.


A0A0G2JN68_HUMAN Killer cell immunoglobulin-like receptor 2DL5B (trembl)


PGBD2_HUMAN PiggyBac transposable element-derived protein 2 (sprot)

A piggyBac transposable element-derived protein 2 that is encoded in the genome of human.


C2D2B_HUMAN Protein CC2D2B (sprot)

A protein CC2D2B that is encoded in the genome of human.


histone H3-K36 trimethylation

The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone.


regulation of plasma membrane sterol distribution

Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane.


A0A0B4J2B6_HUMAN Immunoglobulin heavy variable 2/OR16-5 (non-functional) (Fragment) (trembl)


cysteine biosynthetic process from serine

The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.


tRNA wobble adenosine to inosine editing

The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine.


DR4L1_HUMAN Putative dehydrogenase/reductase SDR family member 4-like 1 (sprot)


cytoplasmic U snRNP body

A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies.


CCNJ_HUMAN Cyclin-J (sprot)

A cyclin-J that is encoded in the genome of human.


RS10L_HUMAN Putative ribosomal protein eS10-like (sprot)


A0A191URJ7_HUMAN KIR2DL protein (trembl)


ANR42_HUMAN Ankyrin repeat domain-containing protein 42 (sprot)

An ankyrin repeat domain-containing protein 42 that is encoded in the genome of human.


A0A075B7F1_HUMAN Immunoglobulin heavy variable 3/OR16-8 (non-functional) (Fragment) (trembl)


DJC25_HUMAN DnaJ homolog subfamily C member 25 (sprot)

A DnaJ homolog subfamily C member 25 that is encoded in the genome of human.


O-glycan processing, core 1

The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc.


phenylacetate catabolic process

The chemical reactions and pathways resulting in the breakdown of phenylacetate.


PAL4D_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4D (sprot)

A protein that is a translation product of the PPIAL4D gene in human.


LRRC2_HUMAN Leucine-rich repeat-containing protein 2 (sprot)

A leucine-rich repeat-containing protein 2 that is encoded in the genome of human.


MCAF2_HUMAN Activating transcription factor 7-interacting protein 2 (sprot)

An activating transcription factor 7-interacting protein 2 that is encoded in the genome of human.


The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.


HNRC4_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 4 (sprot)

A protein that is a translation product of the HNRNPCL4 gene in human.


guanine transport

The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


GPR33_HUMAN Probable G-protein coupled receptor 33 (sprot)

A probable G-protein coupled receptor 33 that is encoded in the genome of human.


negative regulation of RNA catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process.


UDP-N-acetylgalactosamine transmembrane transporter activity

Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


adenine salvage

Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis.


butyrate catabolic process

The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid.


SPDE5_HUMAN Speedy protein E5 (sprot)

A protein that is a translation product of the SPDYE5 gene in human.


PAB4L_HUMAN Polyadenylate-binding protein 4-like (sprot)

A polyadenylate-binding protein 4-like that is encoded in the genome of human.


muscle cell fate specification

The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M.


N-terminal peptidyl-alanine methylation

The methylation of the N-terminal alanine of proteins.


arginine biosynthetic process via ornithine

The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.


protein localization to kinetochore involved in kinetochore assembly

Any protein localization to kinetochore that is involved in kinetochore assembly.


A0A5K1VDZ0_HUMAN KIR2DL1 protein (trembl)


Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.


GRIN3_HUMAN G protein-regulated inducer of neurite outgrowth 3 (sprot)

A G protein-regulated inducer of neurite outgrowth 3 that is encoded in the genome of human.


STMD1_HUMAN Stathmin domain-containing protein 1 (sprot)

A stathmin domain-containing protein 1 that is encoded in the genome of human.


leucine biosynthetic process

The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.


MRCOL_HUMAN MARCO-like protein (sprot)

A protein that is a translation product of the MARCOL gene in human.


CDP biosynthetic process

The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate.


kisspeptin receptor binding

Binding to a kisspeptin receptor.


biological process involved in interspecies interaction between organisms

Any process evolved to enable an interaction with an organism of a different species.


guanine deaminase activity

Catalysis of the reaction: guanine + H2O = xanthine + NH3.


translation reinitiation

A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.


DNA strand elongation involved in mitotic DNA replication

Any DNA strand elongation involved in mitotic cell cycle DNA replication.


KCP_HUMAN Kielin/chordin-like protein (sprot)

A cysteine-rich motor neuron 2 protein that is encoded in the genome of human.


WFD11_HUMAN Protein WFDC11 (sprot)

A protein WFDC11 that is encoded in the genome of human.


Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O.


[pyruvate dehydrogenase (lipoamide)] phosphatase activity

Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate.


transport along microtubule

The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.


TM209_HUMAN Transmembrane protein 209 (sprot)

A transmembrane protein 209 that is encoded in the genome of human.


somatic recombination of immunoglobulin genes involved in immune response

The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.


Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O.


trans-synaptic signaling by neuropeptide, modulating synaptic transmission

Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.


PAL4E_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4E (sprot)

A protein that is a translation product of the PPIAL4E gene in human.


D-ribose metabolic process

The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12.


PRS45_HUMAN Putative serine protease 45 (sprot)

A putative serine protease 45 that is encoded in the genome of human.


prostacyclin receptor activity

Combining with prostacyclin (PGI(2)) to initiate a change in cell activity.


cytosolic tRNA wobble base thiouridylase complex

A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets.


GOG8J_HUMAN Golgin subfamily A member 8J (sprot)

A golgin subfamily A member 8J that is encoded in the genome of human.


GOG8S_HUMAN Golgin subfamily A member 8S (sprot)

A protein that is a translation product of the GOLGA8S gene in human.


WDR5B_HUMAN WD repeat-containing protein 5B (sprot)

A WD repeat-containing protein 5B that is encoded in the genome of human.


PRS29_HUMAN Putative serine protease 29 (sprot)


CHCH9_HUMAN Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (sprot)


CCNI2_HUMAN Cyclin-I2 (sprot)

A cyclin-I2 that is encoded in the genome of human.


SPDE7_HUMAN Putative speedy protein E7 (sprot)


TT39C_HUMAN Tetratricopeptide repeat protein 39C (sprot)

A tetratricopeptide repeat protein 39C that is encoded in the genome of human.


N-acetylglucosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.


vitamin A import into cell

The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid.


organic acid binding

Binding to an organic acid, any acidic compound containing carbon in covalent linkage.


NADHX epimerase activity

Catalysis of the reaction: (R)-NADHX = (S)-NADHX.


Seh1-associated complex

A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.


histone H3 acetylation

The modification of histone H3 by the addition of an acetyl group.


A0A126GWB0_HUMAN Olfactory receptor (trembl)


eRF1 methyltransferase complex

A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p.


gonadotropin hormone-releasing hormone activity

The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary.


T cell tolerance induction

A process involving any mechanism for tolerance induction in T cells.


LHPL7_HUMAN LHFPL tetraspan subfamily member 7 protein (sprot)

An LHFPL tetraspan subfamily member 7 protein that is encoded in the genome of human.


classical-complement-pathway C3/C5 convertase complex

A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone.


negative regulation of gastrin-induced gastric acid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of gastrin-induced gastric acid secretion.


arginine catabolic process to glutamate

The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate.


regulation of guanylate cyclase activity

Any process that modulates the frequency, rate or extent of guanylate cyclase activity.


microtubule plus end polymerase

Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers.


Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O.


mitotic DNA damage checkpoint signaling

A signal transduction process involved in mitotic DNA damage checkpoint.


gluconokinase activity

Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+.


LR14B_HUMAN Leucine-rich repeat-containing protein 14B (sprot)

A leucine-rich repeat-containing protein 14B that is encoded in the genome of human.


intracellular sodium activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification.


cytoskeletal rearrangement involved in phagocytosis, engulfment

The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.


U2-type post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6.


regulation of glucosylceramidase activity

Any process that modulates the frequency, rate or extent of glucosylceramidase activity.


arginine catabolic process to ornithine

The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.


negative regulation of cytoplasmic translational initiation in response to stress

Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.


protein kinase D signaling

A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound.


nucleotide-excision repair, DNA damage recognition

The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix.


MF2L2_HUMAN Probable guanine nucleotide exchange factor MCF2L2 (sprot)

A probable guanine nucleotide exchange factor MCF2L2 that is encoded in the genome of human.


slow axonal transport

The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a Slow Component a (SCa) and a Slow Component b (SCb) which differ in transport rates and protein composition.


histone arginine methylation

The modification of a histone by addition of a methyl group to an arginine residue.


neuropeptide Y receptor binding

Binding to a neuropeptide Y receptor.


PONL1_HUMAN Podocan-like protein 1 (sprot)

A podocan-like protein 1 that is encoded in the genome of human.


cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine.


Intermediate conductance calcium-activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


VGLL3_HUMAN Transcription cofactor vestigial-like protein 3 (sprot)

A transcription cofactor vestigial-like protein 3 that is encoded in the genome of human.


SCML4_HUMAN Sex comb on midleg-like protein 4 (sprot)

A sex comb on midleg-like protein 4 that is encoded in the genome of human.


nuclear protein-containing complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.


proteasome storage granule

An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state.


Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.


SPD21_HUMAN Putative speedy protein E21 (sprot)


telomere tethering at nuclear periphery

The process in which a telomere is maintained in a specific location at the nuclear periphery.


DNA recombinase complex

A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA.


MAGBG_HUMAN Melanoma-associated antigen B16 (sprot)

A melanoma-associated antigen B16 that is encoded in the genome of human.


aspartyl-tRNA aminoacylation

The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA.


M4A10_HUMAN Membrane-spanning 4-domains subfamily A member 10 (sprot)

A membrane-spanning 4-domains subfamily A member 10 that is encoded in the genome of human.


meiotic strand invasion involved in reciprocal meiotic recombination

The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.


DUX5_HUMAN Double homeobox protein 5 (sprot)

A double homeobox protein 5 that is encoded in the genome of human.


ubiquitin-like protein binding

Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.


vacuole fusion, non-autophagic

The fusion of two vacuole membranes to form a single vacuole.


GAL3A_HUMAN Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial (sprot)

A glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial that is encoded in the genome of human.


postsynaptic endocytic zone cytoplasmic component

The cytoplasmic component of the postsynaptic endocytic zone.


KI2LB_HUMAN Killer cell immunoglobulin-like receptor 2DL5B (sprot)

A killer cell immunoglobulin-like receptor 2DL5B that is encoded in the genome of human.


DUX3_HUMAN Putative double homeobox protein 3 (sprot)

A putative double homeobox protein 3 that is encoded in the genome of human.


A0A0B4J2B8_HUMAN Immunoglobulin heavy variable 1/OR15-9 (non-functional) (Fragment) (trembl)


MEI1_HUMAN Meiosis inhibitor protein 1 (sprot)

A meiosis inhibitor protein 1 that is encoded in the genome of human.


phagolysosome assembly involved in apoptotic cell clearance

The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance.


GOG8I_HUMAN Putative golgin subfamily A member 8I (sprot)


BTNLA_HUMAN Putative butyrophilin-like protein 10 pseudogene (sprot)


isoleucine biosynthetic process

The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.


CCD82_HUMAN Coiled-coil domain-containing protein 82 (sprot)

A coiled-coil domain-containing protein 82 that is encoded in the genome of human.


GLCI1_HUMAN Glucocorticoid-induced transcript 1 protein (sprot)

A glucocorticoid-induced transcript 1 protein that is encoded in the genome of human.


NUA4L_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 that is encoded in the genome of human.


CPHXL_HUMAN Cytoplasmic polyadenylated homeobox-like protein (sprot)

A protein that is a translation product of the CPHXL gene in human.


single-stranded DNA exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule.


nucleotide-excision repair factor 2 complex

One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.


CRCC2_HUMAN Ciliary rootlet coiled-coil protein 2 (sprot)

A ciliary rootlet coiled-coil protein 2 that is encoded in the genome of human.


MB3L5_HUMAN Putative methyl-CpG-binding domain protein 3-like 5 (sprot)


A0A087WZ39_HUMAN T cell receptor beta variable 15 (Fragment) (trembl)


A0A4W9AIG4_HUMAN Olfactory receptor (trembl)


regulation of cohesin loading

Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin.


RGF1C_HUMAN Ras-GEF domain-containing family member 1C (sprot)

A Ras-GEF domain-containing family member 1C that is encoded in the genome of human.


CTGE9_HUMAN cTAGE family member 9 (sprot)

A cTAGE family member 9 that is encoded in the genome of human.


tryptophan catabolic process to acetyl-CoA

The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA.


establishment of sister chromatid cohesion

The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase.


KANK3_HUMAN KN motif and ankyrin repeat domain-containing protein 3 (sprot)

A KN motif and ankyrin repeat domain-containing protein 3 that is encoded in the genome of human.


mitotic DNA replication preinitiation complex assembly

Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle.


GS1L2_HUMAN Germ cell-specific gene 1-like protein 2 (sprot)

A protein that is a translation product of the GSG1L2 gene in human.


phosphatidylinositol 3-kinase complex, class III, type II

A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.


glucagon receptor binding

Binding to a glucagon receptor.


pre-mRNA 5'-splice site binding

Binding to a pre-mRNA 5' splice site sequence.


RGPD2_HUMAN RANBP2-like and GRIP domain-containing protein 2 (sprot)

A RANBP2-like and GRIP domain-containing protein 2 that is encoded in the genome of human.


A0A075B6H5_HUMAN T cell receptor beta variable 20/OR9-2 (non-functional) (Fragment) (trembl)


valyl-tRNA aminoacylation

The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


oocyte axis specification

The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.


PAL4G_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4G (sprot)

A peptidyl-prolyl cis-trans isomerase A-like 4G that is encoded in the genome of human.


ME15P_HUMAN Putative methyltransferase-like protein 15P1 (sprot)


RAVE complex

A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme.


RRP15_HUMAN RRP15-like protein (sprot)

An RRP15-like protein that is encoded in the genome of human.


COPII receptor activity

Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.


rRNA methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule.


cell wall disruption in another organism

The disruption of the cell wall of another organism, leading to damage or temporary subversion of the cell wall.


granulocyte colony-stimulating factor receptor binding

Binding to a granulocyte colony-stimulating factor receptor.


tRNA import into mitochondrion

The process in which a tRNA is transported from the cytosol into the mitochondrial matrix.


The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.


A0A075B7B6_HUMAN Immunoglobulin heavy variable 4/OR15-8 (non-functional) (Fragment) (trembl)


microtubule nucleation by interphase microtubule organizing center

The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation.


B7ZLF3_HUMAN C2H2-type domain-containing protein (trembl)


BT2A3_HUMAN Putative butyrophilin subfamily 2 member A3 (sprot)


GKN3_HUMAN Gastrokine-3 (sprot)

A protein that is a translation product of the GKN3P gene in human.


AB12B_HUMAN Protein ABHD12B (sprot)

A protein ABHD12B that is encoded in the genome of human.


CC191_HUMAN Coiled-coil domain-containing protein 191 (sprot)

A protein that is a translation product of the CCDC191 gene in human.


m-AAA complex

Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria.


nucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.


D4 dopamine receptor binding

Binding to a D4 dopamine receptor.


saccharopine dehydrogenase activity

Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor.


SREBP-SCAP complex

A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed.


vacuolar protein processing

Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.


putrescine binding

Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.


Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.


RGPD4_HUMAN RanBP2-like and GRIP domain-containing protein 4 (sprot)

A RanBP2-like and GRIP domain-containing protein 4 that is encoded in the genome of human.


meiotic DNA recombinase assembly

During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA.


positive regulation of glutamate-cysteine ligase activity

Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.


fumarylacetoacetase activity

Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+.


D-alanine transport

The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


RGPD3_HUMAN RanBP2-like and GRIP domain-containing protein 3 (sprot)

A RanBP2-like and GRIP domain-containing protein 3 that is encoded in the genome of human.


histone deubiquitination

The modification of histones by removal of ubiquitin groups.


regulation of establishment of bipolar cell polarity

Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane.


transcription regulator activity

A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.


IQCF5_HUMAN IQ domain-containing protein F5 (sprot)

An IQ domain-containing protein F5 that is encoded in the genome of human.


leucine-rich repeat-containing protein 29 (human)

A leucine-rich repeat-containing protein 29 that is encoded in the genome of human.


TLDC2_HUMAN TLD domain-containing protein 2 (sprot)

A TLD domain-containing protein 2 that is encoded in the genome of human.


interleukin-8 production

The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


LRC27_HUMAN Leucine-rich repeat-containing protein 27 (sprot)

A leucine-rich repeat-containing protein 27 that is encoded in the genome of human.


SPD9_HUMAN Putative speedy protein E9 (sprot)


MSD1_HUMAN Myb/SANT-like DNA-binding domain-containing protein 1 (sprot)

A Myb/SANT-like DNA-binding domain-containing protein 1 that is encoded in the genome of human.


recombinase activator activity

Binds to and increases the activity of a recombinase.


IGFL4_HUMAN Insulin growth factor-like family member 4 (sprot)

An insulin growth factor-like family member 4 that is encoded in the genome of human.


S36A3_HUMAN Proton-coupled amino acid transporter 3 (sprot)

A proton-coupled amino acid transporter 3 that is encoded in the genome of human.


histone H2B conserved C-terminal lysine ubiquitination

A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals.


cargo adaptor activity

Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery.


LHPL6_HUMAN LHFPL tetraspan subfamily member 6 protein (sprot)

An LHFPL tetraspan subfamily member 6 protein that is encoded in the genome of human.


maturation of 5S rRNA

Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule.


mitotic cell cycle checkpoint signaling

A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.


DE10B_HUMAN Putative DENN domain-containing protein 10 B (sprot)

A putative DENN domain-containing protein 10 B that is encoded in the genome of human.


regulation of Rho guanyl-nucleotide exchange factor activity

Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.


D-serine transport

The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


nickel cation transmembrane transporter activity

Enables the transfer of nickel (Ni) cations from one side of a membrane to the other.


palmitoyl-CoA 9-desaturase activity

Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O.


nuclear pore inner ring

A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex.


TM9S3_HUMAN Transmembrane 9 superfamily member 3 (sprot)

A transmembrane 9 superfamily member 3 that is encoded in the genome of human.


MAGBH_HUMAN Melanoma-associated antigen B17 (sprot)


negative regulation of alkaline phosphatase activity

Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.


Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.


tRNA-type intron splice site recognition and cleavage

RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.


acetolactate synthase complex

A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate.


tyrosine biosynthetic process

The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.


KI2LA_HUMAN Killer cell immunoglobulin-like receptor 2DL5A (sprot)

A killer cell immunoglobulin-like receptor 2DL5A that is encoded in the genome of human.


RNA polymerase II, holoenzyme

A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters.


MAB6B_HUMAN Melanoma-associated antigen B6B (sprot)


glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate.


corticotropin-releasing hormone receptor activity

Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity.