fatty acid metabolic process

The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.


ether lipid biosynthetic process

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The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.


TPC13_HUMAN Trafficking protein particle complex subunit 13 (sprot)

A trafficking protein particle complex subunit 13 that is encoded in the genome of human.


endoplasmic reticulum to Golgi vesicle-mediated transport

The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.


vesicle coating

A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination.


vesicle tethering

The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion.


TRAPPII protein complex

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A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself.


5HT3E_HUMAN 5-hydroxytryptamine receptor 3E (sprot)

A 5-hydroxytryptamine receptor 3E that is encoded in the genome of human.


serotonin-gated monoatomic cation-selective channel activity

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Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.


serotonin receptor signaling pathway

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The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.


excitatory postsynaptic potential

A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


inorganic cation transmembrane transport

A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


serotonin-activated cation-selective channel complex

A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist.


CNOT1_HUMAN CCR4-NOT transcription complex subunit 1 (sprot)

A CCR4-NOT transcription complex subunit 1 that is encoded in the genome of human.


poly(A)-specific ribonuclease activity

Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.


protein domain specific binding

Binding to a specific domain of a protein.


nuclear estrogen receptor binding

Binding to a nuclear estrogen receptor.


nuclear retinoic acid receptor binding

Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.


molecular adaptor activity

The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.


armadillo repeat domain binding

Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation.


nuclear-transcribed mRNA poly(A) tail shortening

Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.


trophectodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.


positive regulation of cytoplasmic mRNA processing body assembly

Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.


negative regulation of intracellular estrogen receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


miRNA-mediated gene silencing

A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.


negative regulation of retinoic acid receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.


positive regulation of mRNA catabolic process

Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.


regulation of stem cell population maintenance

Any process that modulates the frequency, rate or extent of stem cell population maintenance.


CCR4-NOT complex

The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8.


CRNS1_HUMAN Carnosine synthase 1 (sprot)

A carnosine synthase 1 that is encoded in the genome of human.


carnosine biosynthetic process

The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine).


carnosine synthase activity

Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine.


homocarnosine synthase activity

Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate.


histidine catabolic process

The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.


MEG11_HUMAN Multiple epidermal growth factor-like domains protein 11 (sprot)

A multiple epidermal growth factor-like domains protein 11 that is encoded in the genome of human.


retina layer formation

The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.


homotypic cell-cell adhesion

The attachment of a cell to a second cell of the identical type via adhesion molecules.


basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.


CDHR4_HUMAN Cadherin-related family member 4 (sprot)

A cadherin-like protein 29 that is encoded in the genome of human.


homophilic cell adhesion via plasma membrane adhesion molecules

The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.


BDP1_HUMAN Transcription factor TFIIIB component B'' homolog (sprot)

A transcription factor TFIIIB component B'' that is encoded in the genome of human.


F221B_HUMAN Protein FAM221B (sprot)

A protein FAM221B that is encoded in the genome of human.


T150B_HUMAN Modulator of macroautophagy TMEM150B (sprot)

A modulator of macroautophagy TMEM150B that is encoded in the genome of human.


autophagy

The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.


PINLY_HUMAN phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (sprot)

A phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein that is encoded in the genome of human.


phospholipase inhibitor activity

Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid.


F172B_HUMAN Putative protein FAM172B (sprot)


CC88B_HUMAN Coiled-coil domain-containing protein 88B (sprot)

A coiled-coil domain-containing protein 88B that is encoded in the genome of human.


positive regulation of cytokine production

Any process that activates or increases the frequency, rate or extent of production of a cytokine.


positive regulation of T cell proliferation

Any process that activates or increases the rate or extent of T cell proliferation.


defense response to protozoan

Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.


positive regulation of T cell activation

Any process that activates or increases the frequency, rate or extent of T cell activation.


GOG8O_HUMAN Golgin subfamily A member 8O (sprot)

A protein that is a translation product of the GOLGA8O gene in human.


MP3B2_HUMAN Microtubule-associated proteins 1A/1B light chain 3 beta 2 (sprot)

A microtubule-associated proteins 1A/1B light chain 3 beta 2 that is encoded in the genome of human.


endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.


cytoplasmic vesicle

A vesicle found in the cytoplasm of a cell.


VWA3A_HUMAN von Willebrand factor A domain-containing protein 3A (sprot)

A von Willebrand factor A domain-containing protein 3A that is encoded in the genome of human.


SIM16_HUMAN Putative transmembrane protein encoded by LINC00862 (sprot)


TKTI1_HUMAN Tektin bundle-interacting protein 1 (sprot)

A tektin bundle-interacting protein 1 that is encoded in the genome of human.


axonemal microtubule

A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.


TR43B_HUMAN Tripartite motif-containing protein 43B (sprot)

A tripartite motif-containing protein that is a translation product of the TRIM43B gene in human.


GEMC1_HUMAN Geminin coiled-coil domain-containing protein 1 (sprot)

A geminin coiled-coil domain-containing protein 1 that is encoded in the genome of human.


chromatin binding

Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.


DNA replication

The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.


cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.


LRCL1_HUMAN Leucine-rich colipase-like protein 1 (sprot)

A leucine-rich colipase-like protein 1 that is encoded in the genome of human.


IQCAL_HUMAN IQ and AAA domain-containing protein 1-like (sprot)

An IQ and AAA domain-containing protein 1-like that is encoded in the genome of human.


microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.


KR87P_HUMAN Putative keratin-87 protein (sprot)


RN222_HUMAN RING finger protein 222 (sprot)

A RING finger protein 222 that is encoded in the genome of human.


NKX26_HUMAN Homeobox protein Nkx-2.6 (sprot)

A homeobox protein Nkx-2.6 that is encoded in the genome of human.


DNA-binding transcription activator activity, RNA polymerase II-specific

A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.


hypothalamus development

The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.


epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.


embryonic heart tube development

The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.


tongue development

The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.


digestive tract development

The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.


atrial cardiac muscle cell development

The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ.


ventricular cardiac muscle cell development

The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.


pharyngeal system development

The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.


pericardium development

The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery.


epithelial cell apoptotic process

Any apoptotic process in an epithelial cell.


negative regulation of epithelial cell apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process.


O6C74_HUMAN Olfactory receptor 6C74 (sprot)

An olfactory receptor 6C74 that is encoded in the genome of human.


U17L3_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 (sprot)

A ubiquitin carboxyl-terminal hydrolase 17-like protein 3 that is encoded in the genome of human.


U17L4_HUMAN Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4 (sprot)

An inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4 that is encoded in the genome of human.


JUNO_HUMAN Sperm-egg fusion protein Juno (sprot)

A sperm-egg fusion protein Juno that is encoded in the genome of human.


folic acid binding

Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.


signaling receptor activity

Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.


single fertilization

The union of male and female gametes to form a zygote.


fusion of sperm to egg plasma membrane involved in single fertilization

The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.


sperm-egg recognition

The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.


microvillus membrane

The portion of the plasma membrane surrounding a microvillus.


FA83G_HUMAN Protein FAM83G (sprot)

A protein FAM83G that is encoded in the genome of human.


BMP signaling pathway

The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


O14I1_HUMAN Olfactory receptor 14I1 (sprot)

An olfactory receptor 14I1 that is encoded in the genome of human.


ASPDH_HUMAN Aspartate dehydrogenase domain-containing protein (sprot)

An aspartate dehydrogenase domain-containing protein that is encoded in the genome of human.


aspartate dehydrogenase activity

Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+.


NADP binding

Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.


NAD biosynthetic process

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.


LRIT2_HUMAN Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 (sprot)

A leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 that is encoded in the genome of human.


PALM3_HUMAN Paralemmin-3 (sprot)

A paralemmin-3 that is encoded in the genome of human.


negative regulation of cytokine-mediated signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.


Toll signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


regulation of cell shape

Any process that modulates the surface configuration of a cell.


response to lipopolysaccharide

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.


SYN1L_HUMAN Synapse differentiation-inducing gene protein 1-like (sprot)

A capucin that is encoded in the genome of human.


RBY1B_HUMAN RNA-binding motif protein, Y chromosome, family 1 member B (sprot)

An RNA-binding motif protein, Y chromosome, family 1 member B that is encoded in the genome of human.


male gonad development

The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.


PGP_HUMAN Glycerol-3-phosphate phosphatase (sprot)

A glycerol-3-phosphate phosphatase that is encoded in the genome of human.


glycerol-1-phosphatase activity

Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate.


protein tyrosine phosphatase activity

Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


phosphoglycolate phosphatase activity

Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate.


glycerol-3-phosphatase activity

Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate.


ADP phosphatase activity

Catalysis of the reaction: ADP + H2O = AMP + phosphate.


glycerol biosynthetic process

The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


glycerophospholipid metabolic process

The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.


negative regulation of gluconeogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.


O5H15_HUMAN Olfactory receptor 5H15 (sprot)

An olfactory receptor 5H15 that is encoded in the genome of human.


TR49B_HUMAN Putative tripartite motif-containing protein 49B (sprot)

A putative tripartite motif-containing protein 49B that is encoded in the genome of human.


MT21E_HUMAN Putative methyltransferase-like protein 21E pseudogene (sprot)


methylation

The process in which a methyl group is covalently attached to a molecule.


O6C68_HUMAN Olfactory receptor 6C68 (sprot)

An olfactory receptor 6C68 that is encoded in the genome of human.


MADL2_HUMAN Myeloid-associated differentiation marker-like protein 2 (sprot)

A myeloid-associated differentiation marker-like protein 2 that is encoded in the genome of human.


ME3L1_HUMAN Putative homeobox protein Meis3-like 1 (sprot)


TBC3B_HUMAN TBC1 domain family member 3B (sprot)

A TBC1 domain family member 3B that is encoded in the genome of human.


RIMC1_HUMAN RAB7A-interacting MON1-CCZ1 complex subunit 1 (sprot)

A UPF0600 protein C5orf51 that is encoded in the genome of human.


mitophagy

The selective autophagy process in which a mitochondrion is degraded by macroautophagy.


TMM8B_HUMAN Transmembrane protein 8B (sprot)

A transmembrane protein 8B that is encoded in the genome of human.


cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules.


regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.


cell surface

The external part of the cell wall and/or plasma membrane.


YO011_HUMAN Putative transmembrane protein ENSP00000320207 (sprot)


ZN840_HUMAN Putative zinc finger protein 840 (sprot)


EPAB2_HUMAN Embryonic polyadenylate-binding protein 2 (sprot)

An embryonic polyadenylate-binding protein 2 that is encoded in the genome of human.


BTBDH_HUMAN BTB/POZ domain-containing protein 17 (sprot)

A BTB/POZ domain-containing protein 17 that is encoded in the genome of human.


response to virus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.


negative regulation of viral genome replication

Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.


MB3L3_HUMAN Putative methyl-CpG-binding domain protein 3-like 3 (sprot)


PSAL_HUMAN Puromycin-sensitive aminopeptidase-like protein (sprot)


RCCD1_HUMAN RCC1 domain-containing protein 1 (sprot)

An RCC1 domain-containing protein 1 that is encoded in the genome of human.


chromatin organization

The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.


TM247_HUMAN Transmembrane protein 247 (sprot)

A transmembrane protein 247 that is encoded in the genome of human.


SWAHB_HUMAN Ankyrin repeat domain-containing protein SOWAHB (sprot)

An ankyrin repeat domain-containing protein SOWAHB that is encoded in the genome of human.


F86C2_HUMAN Putative protein FAM86C2P (sprot)


methyltransferase activity

Catalysis of the transfer of a methyl group to an acceptor molecule.


GG6L9_HUMAN Golgin subfamily A member 6-like protein 9 (sprot)

A golgin subfamily A member 6-like protein 9 that is encoded in the genome of human.


RBY1E_HUMAN RNA-binding motif protein, Y chromosome, family 1 member E (sprot)

An RNA-binding motif protein, Y chromosome, family 1 member E that is encoded in the genome of human.


TBC3F_HUMAN TBC1 domain family member 3F (sprot)

A TBC1 domain family member 3F that is encoded in the genome of human.


OR5K3_HUMAN Olfactory receptor 5K3 (sprot)

An olfactory receptor 5K3 that is encoded in the genome of human.


PRXD1_HUMAN Putative prolyl-tRNA synthetase associated domain-containing protein 1 (sprot)


aminoacyl-tRNA editing activity

The hydrolysis of an incorrectly aminoacylated tRNA.


aminoacyl-tRNA metabolism involved in translational fidelity

Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation.


P121B_HUMAN Putative nuclear envelope pore membrane protein POM 121B (sprot)


mRNA transport

The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


ANTRL_HUMAN Anthrax toxin receptor-like (sprot)

An anthrax toxin receptor-like that is encoded in the genome of human.


CC182_HUMAN Coiled-coil domain-containing protein 182 (sprot)

A coiled-coil domain-containing protein 182 that is encoded in the genome of human.


female gonad development

The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.


NUPR2_HUMAN Nuclear protein 2 (sprot)

A nuclear protein 2 that is encoded in the genome of human.


cellular response to starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.


regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.


OR6C6_HUMAN Olfactory receptor 6C6 (sprot)

An olfactory receptor 6C6 that is encoded in the genome of human.


lipid droplet

An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.


S31F3_HUMAN Protein SPATA31F3 (sprot)

A protein FAM205C that is encoded in the genome of human.


TIKI2_HUMAN Metalloprotease TIKI2 (sprot)

A metalloprotease TIKI2 that is encoded in the genome of human.


Wnt-protein binding

Binding to a Wnt-protein, a secreted growth factor involved in signaling.


negative regulation of Wnt signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.


positive regulation of protein-containing complex assembly

Any process that activates or increases the frequency, rate or extent of protein complex assembly.


positive regulation of protein oxidation

Any process that activates or increases the frequency, rate or extent of protein oxidation.


organelle membrane

A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.


TM235_HUMAN Transmembrane protein 235 (sprot)

A transmembrane protein 235 that is encoded in the genome of human.


OR2W5_HUMAN Putative olfactory receptor 2W5 pseudogene (sprot)

A protein that is a translation product of the OR2W5 gene in human.


HELT_HUMAN Hairy and enhancer of split-related protein HELT (sprot)

A hairy and enhancer of split-related protein HELT that is encoded in the genome of human.


protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.


suckling behavior

Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.


central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.


post-embryonic development

The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.


GABAergic neuron differentiation in basal ganglia

The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron.


transcription regulator complex

A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.


SMCO2_HUMAN Single-pass membrane and coiled-coil domain-containing protein 2 (sprot)

A single-pass membrane and coiled-coil domain-containing protein 2 that is encoded in the genome of human.


EFC10_HUMAN EF-hand calcium-binding domain-containing protein 10 (sprot)

An EF-hand calcium-binding domain-containing protein 10 that is encoded in the genome of human.


NP1L6_HUMAN Putative nucleosome assembly protein 1-like 6 (sprot)


FBP12_HUMAN Fatty acid-binding protein 12 (sprot)

A fatty acid-binding protein 12 that is encoded in the genome of human.


ZN316_HUMAN Zinc finger protein 316 (sprot)

A zinc finger protein 316 that is encoded in the genome of human.


GRCR2_HUMAN Glutaredoxin domain-containing cysteine-rich protein 2 (sprot)

A glutaredoxin domain-containing cysteine-rich protein 2 that is encoded in the genome of human.


protein localization to organelle

A process in which a protein is transported to, or maintained in, a location within an organelle.


microvillus

Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.


RFOX3_HUMAN RNA binding protein fox-1 homolog 3 (sprot)

An RNA binding protein fox-1 homolog 3 that is encoded in the genome of human.


TCAF2_HUMAN TRPM8 channel-associated factor 2 (sprot)

A TRPM8 channel-associated factor 2 that is encoded in the genome of human.


transmembrane transporter binding

Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.


negative regulation of anion channel activity

Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity.


positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.


positive regulation of protein targeting to membrane

Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.


DPRX_HUMAN Divergent paired-related homeobox (sprot)

A divergent paired-related homeobox that is encoded in the genome of human.


CE060_HUMAN Uncharacterized protein C5orf60 (sprot)

A protein that is a translation product of the C5orf60 gene in human.


CFA73_HUMAN Cilia- and flagella-associated protein 73 (sprot)

A cilia- and flagella-associated protein 73 that is encoded in the genome of human.


dynein complex binding

Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.


inner dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


axonemal outer doublet

Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium.


F187A_HUMAN Ig-like V-type domain-containing protein FAM187A (sprot)

An Ig-like V-type domain-containing protein FAM187A that is encoded in the genome of human.


PGPIL_HUMAN Pyroglutamyl-peptidase 1-like protein (sprot)

A pyroglutamyl-peptidase 1-like protein that is encoded in the genome of human.


cysteine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


MFS2B_HUMAN Sphingosine-1-phosphate transporter MFSD2B (sprot)

A sphingosine-1-phosphate transporter MFSD2B that is encoded in the genome of human.


symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.


sphingolipid transporter activity

Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


sphingosine-1-phosphate receptor signaling pathway

A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


carbohydrate transport

The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.


positive regulation of platelet aggregation

Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.


NEMP2_HUMAN Nuclear envelope integral membrane protein 2 (sprot)

A nuclear envelope integral membrane protein 2 that is encoded in the genome of human.


SDHF1_HUMAN Succinate dehydrogenase assembly factor 1, mitochondrial (sprot)

A succinate dehydrogenase assembly factor 1, mitochondrial that is encoded in the genome of human.


mitochondrial respiratory chain complex II assembly

The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane.


FA24A_HUMAN Protein FAM24A (sprot)

A protein FAM24A that is encoded in the genome of human.


MGT4D_HUMAN Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D (sprot)

An alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D that is encoded in the genome of human.


negative regulation of protein glycosylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.


T191C_HUMAN Transmembrane protein 191C (sprot)

A transmembrane protein 191C that is encoded in the genome of human.


TM221_HUMAN Transmembrane protein 221 (sprot)

A transmembrane protein 221 that is encoded in the genome of human.


WIPF3_HUMAN WAS/WASL-interacting protein family member 3 (sprot)

A WAS/WASL-interacting protein family member 3 that is encoded in the genome of human.


TLCD2_HUMAN TLC domain-containing protein 2 (sprot)

A TLC domain-containing protein 2 that is encoded in the genome of human.


plasma membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.


phospholipid homeostasis

Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.


membrane assembly

The aggregation, arrangement and bonding together of a set of components to form a membrane.


regulation of membrane lipid distribution

Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane.


ZSA5C_HUMAN Zinc finger and SCAN domain-containing protein 5C (sprot)

A zinc finger and SCAN domain-containing protein 5C that is encoded in the genome of human.


DC8L1_HUMAN DDB1- and CUL4-associated factor 8-like protein 1 (sprot)

A DDB1- and CUL4-associated factor 8-like protein 1 that is encoded in the genome of human.


URAD_HUMAN Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (sprot)

A putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase that is encoded in the genome of human.


carboxy-lyase activity

Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.


allantoin metabolic process

The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism.


purine nucleobase metabolic process

The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.


PCARE_HUMAN Photoreceptor cilium actin regulator (sprot)

A photoreceptor cilium actin regulator that is encoded in the genome of human.


visual perception

The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.


response to stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.


cone photoreceptor outer segment

The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins.


ANR61_HUMAN Ankyrin repeat domain-containing protein 61 (sprot)

An ankyrin repeat domain-containing protein 61 that is encoded in the genome of human.


TRI64_HUMAN Tripartite motif-containing protein 64 (sprot)

A tripartite motif-containing protein 64 that is encoded in the genome of human.


GAG10_HUMAN G antigen 10 (sprot)

A G antigen 10 that is encoded in the genome of human.


PRA25_HUMAN PRAME family member 25 (sprot)

A protein that is a translation product of the PRAMEF25 gene in human.


IGLO5_HUMAN IgLON family member 5 (sprot)

An IgLON family member 5 that is encoded in the genome of human.


OOEP_HUMAN Oocyte-expressed protein homolog (sprot)

An oocyte-expressed protein that is encoded in the genome of human.


regulation of protein localization

Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.


positive regulation of meiotic nuclear division

Any process that activates or increases the frequency, rate or extent of meiosis.


establishment of spindle localization

The directed movement of the spindle to a specific location in the cell.


regulation of cell division

Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.


regulation of establishment of protein localization

Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.


positive regulation of double-strand break repair via homologous recombination

Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination.


positive regulation of double-strand break repair

Any process that activates or increases the frequency, rate or extent of double-strand break repair.


protein-containing complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.


subcortical maternal complex

Comprised of at least NLRP5, OOEP, TLE6, and KHDC3/KHDC3L with evidence of additional SCMC-associated proteins that interact with one or multiple members of the core complex.


GGT3_HUMAN Putative glutathione hydrolase 3 proenzyme (sprot)


leukotriene C4 gamma-glutamyl transferase activity

Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid.


glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.


leukotriene D4 biosynthetic process

The chemical reactions and pathways resulting in the formation of leukotriene D4.


STRCL_HUMAN Putative stereocilin-like protein (sprot)


FRG2C_HUMAN Protein FRG2-like-2 (sprot)

A protein FRG2-like-2 that is encoded in the genome of human.


O51F1_HUMAN Olfactory receptor 51F1 (sprot)

An olfactory receptor 51F1 that is encoded in the genome of human.


SMIM9_HUMAN Small integral membrane protein 9 (sprot)

A small integral membrane protein 9 that is encoded in the genome of human.


OR2T8_HUMAN Olfactory receptor 2T8 (sprot)

An olfactory receptor 2T8 that is encoded in the genome of human.


GLTD2_HUMAN Glycolipid transfer protein domain-containing protein 2 (sprot)

A glycolipid transfer protein domain-containing protein 2 that is encoded in the genome of human.


ceramide 1-phosphate transport

The directed movement of a ceramide 1-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


SERC4_HUMAN Serine incorporator 4 (sprot)

A serine incorporator 4 that is encoded in the genome of human.


phospholipid biosynthetic process

The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.


TV23A_HUMAN Golgi apparatus membrane protein TVP23 homolog A (sprot)

A protein FAM18A that is encoded in the genome of human.


ARL5C_HUMAN Putative ADP-ribosylation factor-like protein 5C (sprot)

A putative ADP-ribosylation factor-like protein 5C that is encoded in the genome of human.


O4C46_HUMAN Olfactory receptor 4C46 (sprot)

An olfactory receptor 4C46 that is encoded in the genome of human.


CAN8_HUMAN Calpain-8 (sprot)

A calpain-8 that is encoded in the genome of human.


DDTL_HUMAN D-dopachrome decarboxylase-like protein (sprot)

A D-dopachrome decarboxylase-like protein that is encoded in the genome of human.


O5H14_HUMAN Olfactory receptor 5H14 (sprot)

An olfactory receptor 5H14 that is encoded in the genome of human.


ZN860_HUMAN Zinc finger protein 860 (sprot)

A zinc finger protein 860 that is encoded in the genome of human.


TBAL3_HUMAN Tubulin alpha chain-like 3 (sprot)

A tubulin alpha chain-like 3 that is encoded in the genome of human.


hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.


OTOL1_HUMAN Otolin-1 (sprot)

An otolin-1 that is encoded in the genome of human.


otolith mineralization

The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear.


protein homooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.


collagen trimer

A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.


NPB15_HUMAN Nuclear pore complex-interacting protein family member B15 (sprot)

A nuclear pore complex-interacting protein family member B15 that is encoded in the genome of human.


FBLL1_HUMAN rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 (sprot)

An rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 that is encoded in the genome of human.


blastocyst hatching

The hatching of the cellular blastocyst from the zona pellucida.


chromatin remodeling

A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.


fibrillar center

A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.


EPOP_HUMAN Elongin BC and Polycomb repressive complex 2-associated protein (sprot)

An elongin BC and Polycomb repressive complex 2-associated protein that is encoded in the genome of human.


protein-containing complex binding

Binding to a macromolecular complex.


stem cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.


transcription elongation-coupled chromatin remodeling

A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation.


ESC/E(Z) complex

A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.


elongin complex

A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits.


SMHD1_HUMAN Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (sprot)

A structural maintenance of chromosomes flexible hinge domain-containing protein 1 that is encoded in the genome of human.


chromosome, telomeric region

The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).


dosage compensation by inactivation of X chromosome

Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.


DNA methylation on cytosine within a CG sequence

The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule.


nose development

The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).


positive regulation of DNA repair

Any process that activates or increases the frequency, rate or extent of DNA repair.


chromosome organization

A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.


inactivation of paternal X chromosome by genomic imprinting

Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genomic imprinting.


negative regulation of double-strand break repair via homologous recombination

Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination.


positive regulation of double-strand break repair via nonhomologous end joining

Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.


Barr body

A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.


site of double-strand break

A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


HMX3_HUMAN Homeobox protein HMX3 (sprot)

A homeobox protein HMX3 that is encoded in the genome of human.


embryo implantation

Attachment of the blastocyst to the uterine lining.


neuromuscular process controlling balance

Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.


maternal process involved in female pregnancy

A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.


CAST2_HUMAN Cytosolic arginine sensor for mTORC1 subunit 2 (sprot)

A cytosolic arginine sensor for mTORC1 subunit 2 that is encoded in the genome of human.


arginine binding

Binding to 2-amino-5-(carbamimidamido)pentanoic acid.


GATOR2 complex

A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins.


AKD1B_HUMAN Ankyrin repeat and death domain-containing protein 1B (sprot)

An ankyrin repeat and death domain-containing protein 1B that is encoded in the genome of human.


TR64B_HUMAN Putative tripartite motif-containing protein 64B (sprot)


MSGN1_HUMAN Mesogenin-1 (sprot)

A mesogenin-1 that is encoded in the genome of human.


somitogenesis

The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.


segment specification

The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.


RHG42_HUMAN Rho GTPase-activating protein 42 (sprot)

A Rho GTPase-activating protein 42 that is encoded in the genome of human.


negative regulation of systemic arterial blood pressure

The process that reduces the force with which blood travels through the systemic arterial circulatory system.


negative regulation of Rho protein signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.


activation of GTPase activity

Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.


negative regulation of vascular associated smooth muscle contraction

Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction.


CC154_HUMAN Coiled-coil domain-containing protein 154 (sprot)

A coiled-coil domain-containing protein 154 that is encoded in the genome of human.


tooth eruption

The tooth development process in which the teeth enter the mouth and become visible.


bone resorption

The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.


MYMK_HUMAN Protein myomaker (sprot)

A protein myomaker that is encoded in the genome of human.


muscle organ development

The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.


positive regulation of skeletal muscle hypertrophy

Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy.


NCF1B_HUMAN Putative neutrophil cytosol factor 1B (sprot)


LIRA5_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 5 (sprot)

A leukocyte immunoglobulin-like receptor subfamily A member 5 that is encoded in the genome of human.


negative regulation of interleukin-12 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.


negative regulation of interleukin-13 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production.


positive regulation of interleukin-1 beta production

Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.


positive regulation of interleukin-6 production

Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.


positive regulation of tumor necrosis factor production

Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.


positive regulation of MAPK cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.


positive regulation of inflammatory response

Any process that activates or increases the frequency, rate or extent of the inflammatory response.


positive regulation of cell activation

Any process that activates or increases the frequency, rate or extent of activation.


positive regulation of calcium ion transport

Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


positive regulation of protein tyrosine kinase activity

Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.


CCD69_HUMAN Coiled-coil domain-containing protein 69 (sprot)

A coiled-coil domain-containing protein 69 that is encoded in the genome of human.


spindle midzone assembly

The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap.


midbody

A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.


spindle midzone

The area in the center of the spindle where the spindle microtubules from opposite poles overlap.


U119B_HUMAN Protein unc-119 homolog B (sprot)

A protein unc-119 homolog B that is encoded in the genome of human.


lipid binding

Binding to a lipid.


lipoprotein transport

The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


O6C70_HUMAN Olfactory receptor 6C70 (sprot)

An olfactory receptor 6C70 that is encoded in the genome of human.


S15A5_HUMAN Solute carrier family 15 member 5 (sprot)

A solute carrier family 15 member 5 that is encoded in the genome of human.


peptide transport

The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


RN227_HUMAN RING finger protein 227 (sprot)

A RING finger protein 227 that is encoded in the genome of human.


AGAP5_HUMAN Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 (sprot)

An Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 that is encoded in the genome of human.


WTIP_HUMAN Wilms tumor protein 1-interacting protein (sprot)

A Wilms tumor protein 1-interacting protein that is encoded in the genome of human.


response to hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.


cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.


regulation of cell morphogenesis

Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.


miRNA-mediated gene silencing by inhibition of translation

An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs.


negative regulation of hippo signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.


RP1BL_HUMAN Ras-related protein Rap-1b-like protein (sprot)


NKX63_HUMAN Homeobox protein Nkx-6.3 (sprot)

A homeobox protein Nkx-6.3 that is encoded in the genome of human.


cell fate determination

The cellular developmental process involved in cell fate commitment that occurs after cell fate specification,  in which a cell is irreversibly committed to a cellular developmental fate which is heritable on cell division.


negative regulation of epithelial cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.


NPIB2_HUMAN Putative nuclear pore complex-interacting protein family member B2 (sprot)


IGIP_HUMAN IgA-inducing protein homolog (sprot)

An IgA-inducing protein that is encoded in the genome of human.


MET15_HUMAN 12S rRNA N4-methylcytidine (m4C) methyltransferase (sprot)

A 12S rRNA N4-methylcytidine (m4C) methyltransferase that is encoded in the genome of human.


Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine.


rRNA base methylation

The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.


PRR19_HUMAN Proline-rich protein 19 (sprot)

A proline-rich protein 19 that is encoded in the genome of human.


meiotic cell cycle

Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.


ARGFX_HUMAN Arginine-fifty homeobox (sprot)

An arginine-fifty homeobox that is encoded in the genome of human.


ZSA5B_HUMAN Zinc finger and SCAN domain-containing protein 5B (sprot)

A zinc finger and SCAN domain-containing protein 5B that is encoded in the genome of human.


UNC4_HUMAN Homeobox protein unc-4 homolog (sprot)

A homeobox protein unc-4 that is encoded in the genome of human.


cartilage condensation

The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.


pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.


dorsal spinal cord development

The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input.


olfactory bulb interneuron differentiation

The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb.


common myeloid progenitor cell proliferation

The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.


regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.


NPB13_HUMAN Nuclear pore complex-interacting protein family member B13 (sprot)

A protein that is a translation product of the NPIPB13 gene in human.


F166C_HUMAN Protein FAM166C (sprot)

A protein FAM166C that is encoded in the genome of human.


LRR3C_HUMAN Leucine-rich repeat-containing protein 3C (sprot)

A leucine-rich repeat-containing protein 3C that is encoded in the genome of human.


CD8B2_HUMAN T-cell surface glycoprotein CD8 beta-2 chain (sprot)

A protein that is a translation product of the CD8B2 gene in human.


coreceptor activity

Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.


MHC class I protein binding

Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.


SL9P1_HUMAN Putative SLC9B1-like protein SLC9B1P1 (sprot)


antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).


proton transmembrane transport

The directed movement of a proton across a membrane.


T238L_HUMAN Transmembrane protein 238-like (sprot)

A protein that is a translation product of the TMEM238L gene in human.


intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.


O6C65_HUMAN Olfactory receptor 6C65 (sprot)

An olfactory receptor 6C65 that is encoded in the genome of human.


RIM3C_HUMAN RIMS-binding protein 3C (sprot)

A RIMS-binding protein 3C that is encoded in the genome of human.


TRI75_HUMAN Tripartite motif-containing protein 75 (sprot)

A tripartite motif-containing protein 75 that is encoded in the genome of human.


female meiosis I

The cell cycle process in which the first meiotic division occurs in the female germline.


spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.


IRG1_HUMAN Cis-aconitate decarboxylase (sprot)

An immune-responsive gene 1 protein that is encoded in the genome of human.


aconitate decarboxylase activity

Catalysis of the reaction: cis-aconitate + H+ = CO2 + itaconate.


positive regulation of antimicrobial humoral response

Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response.


defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.


negative regulation of NF-kappaB transcription factor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.


negative regulation of toll-like receptor 2 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.


negative regulation of toll-like receptor 4 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.


cellular response to interferon-beta

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.


negative regulation of innate immune response

Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.


defense response to virus

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.


cellular response to molecule of bacterial origin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.


cellular response to type II interferon

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.


cellular response to interleukin-1

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.


cellular response to tumor necrosis factor

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.


cellular response to progesterone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.


tolerance induction to lipopolysaccharide

Tolerance induction directed at lipopolysaccharide antigens.


positive regulation of reactive oxygen species metabolic process

Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.


ZN233_HUMAN Zinc finger protein 233 (sprot)

A zinc finger protein 233 that is encoded in the genome of human.


LIPT2_HUMAN Putative lipoyltransferase 2, mitochondrial (sprot)

A putative lipoyltransferase 2, mitochondrial that is encoded in the genome of human.


lipoyl(octanoyl) transferase activity

Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein].


protein lipoylation

The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.


carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).


positive regulation of oxygen metabolic process

Any process that activates or increases the frequency, rate or extent of oxygen metabolic process.


ASB14_HUMAN Ankyrin repeat and SOCS box protein 14 (sprot)

An ankyrin repeat and SOCS box protein 14 that is encoded in the genome of human.


ZNF98_HUMAN Zinc finger protein 98 (sprot)

A zinc finger protein 98 that is encoded in the genome of human.


RASFA_HUMAN Ras association domain-containing protein 10 (sprot)

A Ras association domain-containing protein 10 that is encoded in the genome of human.


nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.


positive regulation of neurogenesis

Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.


positive regulation of neural precursor cell proliferation

Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.


spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.


S22AK_HUMAN Solute carrier family 22 member 20 (sprot)

A solute carrier family 22 member 20 that is encoded in the genome of human.


PCX2_HUMAN Pecanex-like protein 2 (sprot)

A pecanex-like protein 2 that is encoded in the genome of human.


TSPY2_HUMAN Testis-specific Y-encoded protein 2 (sprot)

A testis-specific Y-encoded protein 2 that is encoded in the genome of human.


CC85C_HUMAN Coiled-coil domain-containing protein 85C (sprot)

A coiled-coil domain-containing protein 85C that is encoded in the genome of human.


cerebral cortex development

The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.


adherens junction

A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.


bicellular tight junction

An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.


apical junction complex

A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.


SAC31_HUMAN SAC3 domain-containing protein 1 (sprot)

A SAC3 domain-containing protein 1 that is encoded in the genome of human.


ARI3C_HUMAN AT-rich interactive domain-containing protein 3C (sprot)

An AT-rich interactive domain-containing protein 3C that is encoded in the genome of human.


membrane raft

Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.


RTL1_HUMAN Retrotransposon-like protein 1 (sprot)

A retrotransposon-like protein 1 that is encoded in the genome of human.


RL37L_HUMAN Putative ribosomal protein eL43-like (sprot)


cytosolic large ribosomal subunit

The large subunit of a ribosome located in the cytosol.


OR5H1_HUMAN Olfactory receptor 5H1 (sprot)

An olfactory receptor 5H1 that is encoded in the genome of human.


T200C_HUMAN Transmembrane protein 200C (sprot)

A transmembrane protein 200C that is encoded in the genome of human.


D42E2_HUMAN Putative short-chain dehydrogenase/reductase family 42E member 2 (sprot)

A putative short-chain dehydrogenase/reductase family 42E member 2 that is encoded in the genome of human.


Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+.


steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.


CGB1_HUMAN Choriogonadotropin subunit beta variant 1 (sprot)

A choriogonadotropin subunit beta variant 1 that is encoded in the genome of human.


hormone activity

The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.


SHL2B_HUMAN Protein shisa-like-2B (sprot)

A protein shisa-like-2B that is encoded in the genome of human.


S22AV_HUMAN Putative solute carrier family 22 member 31 (sprot)

A putative solute carrier family 22 member 31 that is encoded in the genome of human.


F74A7_HUMAN Protein FAM74A7 (sprot)

A protein FAM74A7 that is encoded in the genome of human.


O6C75_HUMAN Olfactory receptor 6C75 (sprot)

An olfactory receptor 6C75 that is encoded in the genome of human.


O5B21_HUMAN Olfactory receptor 5B21 (sprot)

An olfactory receptor 5B21 that is encoded in the genome of human.


CF144_HUMAN Cilia- and flagella-associated protein 144 (sprot)

A protein FAM183A that is encoded in the genome of human.


SHSA7_HUMAN Protein shisa-7 (sprot)

A protein shisa-7 that is encoded in the genome of human.


ionotropic glutamate receptor binding

Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.


regulation of AMPA glutamate receptor clustering

Any process that modulates the frequency, rate or extent of AMPA glutamate receptor clustering.


regulation of AMPA receptor activity

Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity.


glutamatergic synapse

A synapse that uses glutamate as a neurotransmitter.


asymmetric, glutamatergic, excitatory synapse

A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials.


AMPA glutamate receptor complex

An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.


GABA receptor binding

Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.


gamma-aminobutyric acid signaling pathway

The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell.


memory

The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).


gamma-aminobutyric acid receptor clustering

The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane.


regulation of GABA-A receptor activity

Any process that modulates the frequency, rate or extent of GABA-A receptor activity.


positive regulation of long-term synaptic potentiation

Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.


postsynaptic density

An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.


postsynaptic density membrane

The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.


AQP73_HUMAN Putative aquaporin-7-like protein 3 (sprot)


CC070_HUMAN UPF0524 protein C3orf70 (sprot)

A UPF0524 protein C3orf70 that is encoded in the genome of human.


circadian behavior

The specific behavior of an organism that recurs with a regularity of approximately 24 hours.


TFKL2_HUMAN TATA-box binding protein associated factor 11 like protein 2 (sprot)

A protein that is a translation product of the TAF11L2 gene in human.


SIM23_HUMAN Small integral membrane protein 23 (sprot)

A small integral membrane protein 23 that is encoded in the genome of human.


TR64C_HUMAN Tripartite motif-containing protein 64C (sprot)

A protein that is a translation product of the TRIM64C gene in human.


C2C4B_HUMAN C2 calcium-dependent domain-containing protein 4B (sprot)

A C2 calcium-dependent domain-containing protein 4B that is encoded in the genome of human.


regulation of vascular permeability involved in acute inflammatory response

Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response.


positive regulation of acute inflammatory response

Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.


regulation of cell adhesion

Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.


TTC36_HUMAN Tetratricopeptide repeat protein 36 (sprot)

A tetratricopeptide repeat protein 36 that is encoded in the genome of human.


tyrosine metabolic process

The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.


visual learning

Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.


negative regulation of peptidyl-threonine phosphorylation

Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


central nervous system neuron development

The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.


negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


negative regulation of protein polyubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination.


RFPLA_HUMAN Ret finger protein-like 4A (sprot)

A ret finger protein-like 4A that is encoded in the genome of human.


VTM2B_HUMAN V-set and transmembrane domain-containing protein 2B (sprot)

A V-set and transmembrane domain-containing protein 2B that is encoded in the genome of human.


DUXA_HUMAN Double homeobox protein A (sprot)

A double homeobox protein A that is encoded in the genome of human.


SPDE4_HUMAN Speedy protein E4 (sprot)

A speedy protein E4 that is encoded in the genome of human.


TM210_HUMAN Transmembrane protein 210 (sprot)

A transmembrane protein 210 that is encoded in the genome of human.


O2AG2_HUMAN Olfactory receptor 2AG2 (sprot)

An olfactory receptor 2AG2 that is encoded in the genome of human.


AQ12B_HUMAN Aquaporin-12B (sprot)

An aquaporin-12B that is encoded in the genome of human.


water channel activity

Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.


water transport

The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


L37A2_HUMAN Leucine-rich repeat-containing protein 37A2 (sprot)

A leucine-rich repeat-containing protein 37A2 that is encoded in the genome of human.


ZFP92_HUMAN Zinc finger protein 92 homolog (sprot)

A zinc finger protein 92 homolog that is encoded in the genome of human.


TCPQL_HUMAN Putative T-complex protein 1 subunit theta-like 1 (sprot)


ATP-dependent protein folding chaperone

Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.


O6C76_HUMAN Olfactory receptor 6C76 (sprot)

An olfactory receptor 6C76 that is encoded in the genome of human.


SIG16_HUMAN Sialic acid-binding Ig-like lectin 16 (sprot)

A sialic acid-binding Ig-like lectin 16 that is encoded in the genome of human.


positive regulation of defense response to bacterium

Any process that activates or increases the frequency, rate or extent of defense response to bacterium.


FIGL2_HUMAN Fidgetin-like protein 2 (sprot)

A protein that is a translation product of the FIGNL2 gene in human.


CPS4L_HUMAN Putative cleavage and polyadenylation specificity factor subunit 4-like protein (sprot)

A putative cleavage and polyadenylation specificity factor subunit 4-like protein that is encoded in the genome of human.


TM212_HUMAN Transmembrane protein 212 (sprot)

A transmembrane protein 212 that is encoded in the genome of human.


F170B_HUMAN Protein FAM170B (sprot)

A protein FAM170B that is encoded in the genome of human.


regulation of fertilization

Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).


outer acrosomal membrane

The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.


OR5K4_HUMAN Olfactory receptor 5K4 (sprot)

An olfactory receptor 5K4 that is encoded in the genome of human.


L37A1_HUMAN Leucine-rich repeat-containing protein 37A (sprot)

A leucine-rich repeat-containing protein 37A that is encoded in the genome of human.


DBX1_HUMAN Homeobox protein DBX1 (sprot)

A homeobox protein DBX1 that is encoded in the genome of human.


ventral spinal cord interneuron specification

The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.


O52A4_HUMAN Olfactory receptor 52A4 (sprot)

A protein that is a translation product of the OR52A4P gene in human.


I4E1B_HUMAN Eukaryotic translation initiation factor 4E type 1B (sprot)

A eukaryotic translation initiation factor 4E type 1B that is encoded in the genome of human.


translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


regulation of translation

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.


mRNA cap binding complex

Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.


AXA2L_HUMAN Putative annexin A2-like protein (sprot)


calcium ion transmembrane transport

A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


melanosome

A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.


SNTAN_HUMAN Sentan (sprot)

A sentan that is encoded in the genome of human.


transition metal ion binding

Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.


O4C45_HUMAN Olfactory receptor 4C45 (sprot)

An olfactory receptor 4C45 that is encoded in the genome of human.


CO6A6_HUMAN Collagen alpha-6(VI) chain (sprot)

A collagen alpha-6(VI) chain that is encoded in the genome of human.


extracellular matrix structural constituent conferring tensile strength

A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.


extracellular matrix

A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.


ZN729_HUMAN Zinc finger protein 729 (sprot)

A zinc finger protein 729 that is encoded in the genome of human.


CXE1_HUMAN Putative gap junction epsilon-1 protein (sprot)

A putative gap junction epsilon-1 protein that is encoded in the genome of human.


cell morphogenesis

The developmental process in which the size or shape of a cell is generated and organized.


lens development in camera-type eye

The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.


organ growth

The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.


SRRM3_HUMAN Serine/arginine repetitive matrix protein 3 (sprot)

A serine/arginine repetitive matrix protein 3 that is encoded in the genome of human.


DRGX_HUMAN Dorsal root ganglia homeobox protein (sprot)

A dorsal root ganglia homeobox protein that is encoded in the genome of human.


neuron migration

The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.


detection of chemical stimulus

The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.


detection of temperature stimulus

The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal.


trigeminal nerve development

The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.


sensory perception of mechanical stimulus

The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


IFM5_HUMAN Interferon-induced transmembrane protein 5 (sprot)

An interferon-induced transmembrane protein 5 that is encoded in the genome of human.


bone mineralization

The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.


regulation of bone mineralization

Any process that modulates the frequency, rate or extent of bone mineralization.


bone morphogenesis

The process in which bones are generated and organized.


P12LL_HUMAN Putative POM121-like protein 1-like (sprot)


O2AT4_HUMAN Olfactory receptor 2AT4 (sprot)

An olfactory receptor 2AT4 that is encoded in the genome of human.


olfactory receptor activity

Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.


positive regulation of ERK1 and ERK2 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


MARHB_HUMAN E3 ubiquitin-protein ligase MARCHF11 (sprot)

An E3 ubiquitin-protein ligase MARCHF11 that is encoded in the genome of human.


cytoplasmic vesicle membrane

The lipid bilayer surrounding a cytoplasmic vesicle.


ZN726_HUMAN Zinc finger protein 726 (sprot)

A zinc finger protein 726 that is encoded in the genome of human.


CO061_HUMAN Uncharacterized protein C15orf61 (sprot)

An uncharacterized protein C15orf61 that is encoded in the genome of human.


RIM3B_HUMAN RIMS-binding protein 3B (sprot)

A RIMS-binding protein 3B that is encoded in the genome of human.


TTL13_HUMAN Tubulin polyglutamylase TTLL13 (sprot)

A tubulin polyglutamylase Ttll13 that is encoded in the genome of human.


tubulin-glutamic acid ligase activity

Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.


protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).


S38A8_HUMAN Putative sodium-coupled neutral amino acid transporter 8 (sprot)

A putative sodium-coupled neutral amino acid transporter 8 that is encoded in the genome of human.


L-alpha-amino acid transmembrane transport

The directed movement of L-alpha-amino acid across a membrane.


DRS7C_HUMAN Dehydrogenase/reductase SDR family member 7C (sprot)

A dehydrogenase/reductase SDR family member 7C that is encoded in the genome of human.


NAD-retinol dehydrogenase activity

Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.


intracellular calcium ion homeostasis

A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell.