positive regulation of late endosome to lysosome transport

Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport.


manchette

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A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.


BLOC-1 complex

A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.


cytoplasmic side of lysosomal membrane

The side (leaflet) of the lysosomal membrane that faces the cytoplasm.


BORC complex

A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors.


MPZL1_HUMAN Myelin protein zero-like protein 1 (sprot)

A myelin protein zero-like protein 1 that is encoded in the genome of human.


NDUC2_HUMAN NADH dehydrogenase [ubiquinone] 1 subunit C2 (sprot)

An NADH dehydrogenase [ubiquinone] 1 subunit C2 that is encoded in the genome of human.


NDUAA_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial that is encoded in the genome of human.


FKBP9_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP9 (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP9 that is encoded in the genome of human.


CELF2_HUMAN CUGBP Elav-like family member 2 (sprot)

A CUGBP Elav-like family member 2 that is encoded in the genome of human.


A 6-phosphogluconolactonase that is encoded in the genome of human.


6-phosphogluconolactonase activity

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Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+.


PAPS2_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (sprot)

A bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 that is encoded in the genome of human.


hormone metabolic process

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The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.


ABCBB_HUMAN Bile salt export pump (sprot)

A bile salt export pump that is encoded in the genome of human.


bile acid transmembrane transporter activity

Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.


canalicular bile acid transmembrane transporter activity

The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.


carbohydrate transmembrane transporter activity

Enables the transfer of carbohydrate from one side of a membrane to the other.


regulation of fatty acid beta-oxidation

Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation.


carbohydrate transmembrane transport

The process in which a carbohydrate is transported across a membrane.


bile acid signaling pathway

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The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


xenobiotic export from cell

The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


positive regulation of bile acid secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.


regulation of bile acid metabolic process

Any process that modulates the frequency, rate or extent of bile acid metabolic process.


intercellular canaliculus

An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.


SIX3_HUMAN Homeobox protein SIX3 (sprot)

A homeobox protein SIX3 that is encoded in the genome of human.


epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.


optic vesicle morphogenesis

The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.


proximal/distal axis specification

The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).


neuroblast differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts.


telencephalon development

The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.


forebrain dorsal/ventral pattern formation

The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain.


telencephalon regionalization

The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.


regulation of neural retina development

Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.


neuroblast migration

The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.


regulation of cell cycle phase transition

Any process that modulates the frequency, rate or extent of cell cycle phase transition.


regulation of neuroblast proliferation

Any process that modulates the frequency, rate or extent of neuroblast proliferation.


lens fiber cell apoptotic process

Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


SMC2_HUMAN Structural maintenance of chromosomes protein 2 (sprot)

A structural maintenance of chromosomes protein 2 that is encoded in the genome of human.


meiotic chromosome condensation

Compaction of chromatin structure prior to meiosis in eukaryotic cells.


meiotic chromosome segregation

The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.


positive regulation of chromosome segregation

Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.


positive regulation of chromosome condensation

Any process that activates or increases the frequency, rate or extent of chromosome condensation.


condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis.


ATG7_HUMAN Ubiquitin-like modifier-activating enzyme ATG7 (sprot)

A ubiquitin-like modifier-activating enzyme ATG7 that is encoded in the genome of human.


Atg12 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond.


cellular response to hyperoxia

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.


TACC2_HUMAN Transforming acidic coiled-coil-containing protein 2 (sprot)

A transforming acidic coiled-coil-containing protein 2 that is encoded in the genome of human.


TRI16_HUMAN Tripartite motif-containing protein 16 (sprot)

A tripartite motif-containing protein 16 that is encoded in the genome of human.


NACHT domain binding

Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg2+-binding site and five more specific motifs.


response to organophosphorus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors.


positive regulation of retinoic acid receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


response to growth hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.


SYFM_HUMAN Phenylalanine--tRNA ligase, mitochondrial (sprot)

A phenylalanine--tRNA ligase, mitochondrial that is encoded in the genome of human.


phenylalanine-tRNA ligase activity

Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).


phenylalanyl-tRNA aminoacylation

The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


tRNA processing

The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.


ZBT7A_HUMAN Zinc finger and BTB domain-containing protein 7A (sprot)

A zinc finger and BTB domain-containing protein 7A that is encoded in the genome of human.


histone acetyltransferase binding

Binding to an histone acetyltransferase.


double-strand break repair via classical nonhomologous end joining

An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining).


regulation of transcription regulatory region DNA binding

Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding.


DNA-dependent protein kinase complex

A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku.


OR2C1_HUMAN Olfactory receptor 2C1 (sprot)

An olfactory receptor 2C1 that is encoded in the genome of human.


odorant binding

Binding to an odorant, any substance capable of stimulating the sense of smell.


LYPA2_HUMAN Acyl-protein thioesterase 2 (sprot)

An acyl-protein thioesterase 2 that is encoded in the genome of human.


acylglycerol catabolic process

The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.


prostaglandin catabolic process

The chemical reactions and pathways resulting in the breakdown of prostaglandin.


IPO7_HUMAN Importin-7 (sprot)

An importin-7 that is encoded in the genome of human.


positive regulation of odontoblast differentiation

Any process that activates or increases the frequency, rate or extent of odontoblast differentiation.


ARI2_HUMAN E3 ubiquitin-protein ligase ARIH2 (sprot)

An E3 ubiquitin-protein ligase ARIH2 that is encoded in the genome of human.


Cul5-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


developmental cell growth

The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.


CXB5_HUMAN Gap junction beta-5 protein (sprot)

A gap junction beta-5 protein that is encoded in the genome of human.


labyrinthine layer morphogenesis

The process in which the labyrinthine layer of the placenta is generated and organized.


epididymis development

The process whose specific outcome is the progression of an epididymis over time, from its formation to the mature structure.


TFIP8_HUMAN Tumor necrosis factor alpha-induced protein 8 (sprot)

A tumor necrosis factor alpha-induced protein 8 that is encoded in the genome of human.


M3K6_HUMAN Mitogen-activated protein kinase kinase kinase 6 (sprot)

A mitogen-activated protein kinase kinase kinase 6 that is encoded in the genome of human.


CCN4_HUMAN CCN family member 4 (sprot)

A CCN family member 4 that is encoded in the genome of human.


CCN6_HUMAN Cellular communication network factor 6 (sprot)

A cellular communication network factor 6 that is encoded in the genome of human.


regulation of reactive oxygen species biosynthetic process

Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.


GDF11_HUMAN Growth/differentiation factor 11 (sprot)

A growth/differentiation factor 11 that is encoded in the genome of human.


spinal cord anterior/posterior patterning

The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord.


amacrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons.


type B pancreatic cell maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.


negative regulation of amacrine cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation.


SLU7_HUMAN Pre-mRNA-splicing factor SLU7 (sprot)

A pre-mRNA-splicing factor SLU7 that is encoded in the genome of human.


second spliceosomal transesterification activity

Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.


pre-mRNA 3'-splice site binding

Binding to a pre-mRNA 3' splice site sequence.


mRNA 3'-splice site recognition

Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome.


small nuclear ribonucleoprotein complex

A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs.


BMP10_HUMAN Bone morphogenetic protein 10 (sprot)

A bone morphogenetic protein 10 that is encoded in the genome of human.


telethonin binding

Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.


receptor serine/threonine kinase binding

Binding to a receptor that possesses protein serine/threonine kinase activity.


activin receptor signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


atrial cardiac muscle tissue morphogenesis

The process in which the anatomical structure of cardiac atrium muscle is generated and organized.


cardiac muscle cell proliferation

The expansion of a cardiac muscle cell population by cell division.


positive regulation of cardiac muscle cell proliferation

Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.


positive regulation of sarcomere organization

Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


heart trabecula formation

The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.


positive regulation of cell proliferation involved in heart morphogenesis

Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis.


AGM1_HUMAN Phosphoacetylglucosamine mutase (sprot)

A phosphoacetylglucosamine mutase that is encoded in the genome of human.


Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.


glucosamine metabolic process

The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.


GCNT3_HUMAN Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (sprot)

A beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 that is encoded in the genome of human.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.


Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP.


Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP.


tissue morphogenesis

The process in which the anatomical structures of a tissue are generated and organized.


intestinal absorption

Any process in which nutrients are taken up from the contents of the intestine.


MOCS3_HUMAN Adenylyltransferase and sulfurtransferase MOCS3 (sprot)

An adenylyltransferase and sulfurtransferase MOCS3 that is encoded in the genome of human.


sulfurtransferase activity

Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).


URM1 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond.


Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine = AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase.


Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP.


Mo-molybdopterin cofactor biosynthetic process

The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.


tRNA thio-modification

The addition a sulfur atom to a nucleotide in a tRNA molecule.


molybdopterin cofactor metabolic process

The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.


PKHA9_HUMAN Putative protein PLEKHA9 (sprot)

A putative protein PLEKHA9 that is encoded in the genome of human.


RPGF3_HUMAN Rap guanine nucleotide exchange factor 3 (sprot)

A Rap guanine nucleotide exchange factor 3 that is encoded in the genome of human.


Rap protein signal transduction

The series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.


negative regulation of syncytium formation by plasma membrane fusion

Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


positive regulation of protein export from nucleus

Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.


positive regulation of syncytium formation by plasma membrane fusion

Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


UTS2_HUMAN Urotensin-2 (sprot)

A urotensin-2 that is encoded in the genome of human.


CD2B2_HUMAN CD2 antigen cytoplasmic tail-binding protein 2 (sprot)

A CD2 cytoplasmic tail-binding protein 2 that is encoded in the genome of human.


MED26_HUMAN Mediator of RNA polymerase II transcription subunit 26 (sprot)

A mediator of RNA polymerase II transcription subunit 26 that is encoded in the genome of human.


ZFYV9_HUMAN Zinc finger FYVE domain-containing protein 9 (sprot)

A zinc finger FYVE domain-containing protein 9 that is encoded in the genome of human.


1-phosphatidylinositol binding

Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.


CNIH1_HUMAN Protein cornichon homolog 1 (sprot)

A protein cornichon that is encoded in the genome of human.


TNF6B_HUMAN Tumor necrosis factor receptor superfamily member 6B (sprot)

A tumor necrosis factor receptor superfamily member 6B that is encoded in the genome of human.


ZIC2_HUMAN Zinc finger protein ZIC 2 (sprot)

A zinc finger protein ZIC 2 that is encoded in the genome of human.


BRI3_HUMAN Membrane protein BRI3 (sprot)

A brain protein I3 that is encoded in the genome of human.


SOX14_HUMAN Transcription factor SOX-14 (sprot)

A transcription factor SOX-14 that is encoded in the genome of human.


DEXI_HUMAN Dexamethasone-induced protein (sprot)

A dexamethasone-induced protein that is encoded in the genome of human.


SVIL_HUMAN Supervillin (sprot)

A supervillin that is encoded in the genome of human.


microtubule minus-end

The end of a microtubule that does not preferentially grow (polymerize).


PIGN_HUMAN GPI ethanolamine phosphate transferase 1 (sprot)

A GPI ethanolamine phosphate transferase 1 that is encoded in the genome of human.


Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor.


preassembly of GPI anchor in ER membrane

The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane.


PPN_HUMAN Papilin (sprot)

A papilin that is encoded in the genome of human.


BAG4_HUMAN BAG family molecular chaperone regulator 4 (sprot)

A BAG family molecular chaperone regulator 4 that is encoded in the genome of human.


positive regulation of fibroblast migration

Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.


negative regulation of mRNA modification

Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


negative regulation of protein targeting to mitochondrion

Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion.


AHSA1_HUMAN Activator of 90 kDa heat shock protein ATPase homolog 1 (sprot)

An activator of 90 kDa heat shock protein ATPase homolog 1 that is encoded in the genome of human.


NPT2B_HUMAN Sodium-dependent phosphate transport protein 2B (sprot)

A sodium-dependent phosphate transport protein 2B that is encoded in the genome of human.


protein metabolic process

The chemical reactions and pathways involving a protein. Includes protein modification.


APOM_HUMAN Apolipoprotein M (sprot)

An apolipoprotein M that is encoded in the genome of human.


antioxidant activity

Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.


high-density lipoprotein particle remodeling

The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.


high-density lipoprotein particle assembly

The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.


high-density lipoprotein particle clearance

The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


negative regulation of plasma lipoprotein oxidation

Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein particle oxidation, occurring in the blood plasma.


reverse cholesterol transport

The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism.


low-density lipoprotein particle

A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.


discoidal high-density lipoprotein particle

A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase).


spherical high-density lipoprotein particle

A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).


LCA5L_HUMAN Lebercilin-like protein (sprot)

A lebercilin-like protein that is encoded in the genome of human.


ATS2_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 2 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 2 that is encoded in the genome of human.


CXB6_HUMAN Gap junction beta-6 protein (sprot)

A gap junction beta-6 protein that is encoded in the genome of human.


gap junction channel activity involved in cell communication by electrical coupling

Any gap junction channel activity that is involved in cell communication by electrical coupling.


cell communication by electrical coupling

The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


gap junction assembly

Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids.


gap junction-mediated intercellular transport

The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells.


PARN_HUMAN Poly(A)-specific ribonuclease PARN (sprot)

A poly(A)-specific ribonuclease PARN that is encoded in the genome of human.


cation binding

Binding to a cation, a charged atom or group of atoms with a net positive charge.


box H/ACA RNA 3'-end processing

Any process involved in forming the mature 3' end of a box H/ACA RNA molecule.


RNA modification

The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.


miRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.


polyadenylation-dependent snoRNA 3'-end processing

Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA.


ncRNA deadenylation

Shortening of the poly(A) tail of a nuclear-transcribed ncRNA.


TGDS_HUMAN dTDP-D-glucose 4,6-dehydratase (sprot)

A dTDP-D-glucose 4,6-dehydratase that is encoded in the genome of human.


nucleotide-sugar metabolic process

The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.


PSMG1_HUMAN Proteasome assembly chaperone 1 (sprot)

A proteasome assembly chaperone 1 that is encoded in the genome of human.


cerebellar granule cell precursor proliferation

The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.


MATN4_HUMAN Matrilin-4 (sprot)

A matrilin-4 that is encoded in the genome of human.


LARG1_HUMAN Xylosyl- and glucuronyltransferase LARGE1 (sprot)

A xylosyl- and glucuronyltransferase LARGE1 that is encoded in the genome of human.


xylosyltransferase activity

Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


glycoprotein biosynthetic process

The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.


dentate gyrus development

The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.


multicellular organism reproduction

The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.


post-embryonic hindlimb morphogenesis

The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized.


neuromuscular process controlling posture

Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts.


localization of cell

Any process in which a cell is transported to, and/or maintained in, a specific location.


striated muscle cell development

The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.


retina vasculature development in camera-type eye

The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.


connective tissue development

The progression of a connective tissue over time, from its formation to the mature structure.


walking behavior

The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg.


acetylcholine receptor signaling pathway

The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands.


skeletal muscle fiber differentiation

The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.


reactive gliosis

A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells.


FMNL1_HUMAN Formin-like protein 1 (sprot)

A formin-like protein 1 that is encoded in the genome of human.


bleb

A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.


SGPL1_HUMAN Sphingosine-1-phosphate lyase 1 (sprot)

A sphingosine-1-phosphate lyase 1 that is encoded in the genome of human.


Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.


luteinization

The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.


sphingolipid catabolic process

The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


CLD7_HUMAN Claudin-7 (sprot)

A claudin-7 that is encoded in the genome of human.


SIX6_HUMAN Homeobox protein SIX6 (sprot)

A homeobox protein SIX6 that is encoded in the genome of human.


CNEP1_HUMAN CTD nuclear envelope phosphatase 1 (sprot)

A serine/threonine-protein phosphatase dullard that is encoded in the genome of human.


mitotic nuclear membrane disassembly

The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.


gamete generation

The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.


positive regulation of triglyceride biosynthetic process

Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.


Nem1-Spo7 phosphatase complex

A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p.


ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 (sprot)

A phospholipid-transporting ATPase ABCA1 that is encoded in the genome of human.


phospholipid transporter activity

Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.


high-density lipoprotein particle binding

Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.


apolipoprotein A-I binding

Binding to apolipoprotein A-I.


apolipoprotein A-I receptor activity

Combining with an apolipoprotein A-I receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


sphingolipid floppase activity

Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


cholesterol transfer activity

Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


floppase activity

Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


peptide secretion

The controlled release of a peptide from a cell or a tissue.


phagocytosis, engulfment

The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.


negative regulation of macrophage derived foam cell differentiation

Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


negative regulation of cholesterol storage

Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


signal release

The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.


phospholipid efflux

The directed movement of a phospholipid out of a cell or organelle.


apolipoprotein A-I-mediated signaling pathway

The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


lipoprotein biosynthetic process

The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.


regulation of high-density lipoprotein particle assembly

Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.


positive regulation of high-density lipoprotein particle assembly

Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.


sphingolipid translocation

The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.


NSA2_HUMAN Ribosome biogenesis protein NSA2 homolog (sprot)

A ribosome biogenesis protein NSA2 that is encoded in the genome of human.


G6PE_HUMAN GDH/6PGL endoplasmic bifunctional protein (sprot)

A GDH/6PGL endoplasmic bifunctional protein that is encoded in the genome of human.


Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.


glucose 1-dehydrogenase (NAD+) activity

Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH.


glucose 1-dehydrogenase (NADP+) activity

Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH.


glucose 1-dehydrogenase [NAD(P)] activity

Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.


pentose-phosphate shunt, oxidative branch

The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2).


response to alcohol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.


regulation of cortisol biosynthetic process

Any process that modulates the frequency, rate or extent of cortisol biosynthetic process.


CLD9_HUMAN Claudin-9 (sprot)

A claudin-9 that is encoded in the genome of human.


SC24A_HUMAN Protein transport protein Sec24A (sprot)

A protein transport protein Sec24A that is encoded in the genome of human.


regulation of cholesterol transport

Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


SC24B_HUMAN Protein transport protein Sec24B (sprot)

A protein transport protein Sec24B that is encoded in the genome of human.


cochlear nucleus development

The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure.


lung lobe morphogenesis

The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.


pulmonary artery morphogenesis

The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.


regulation of establishment of planar polarity involved in neural tube closure

Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube.


regulation of cargo loading into COPII-coated vesicle

Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle.


AGRL2_HUMAN Adhesion G protein-coupled receptor L2 (sprot)

An adhesion G protein-coupled receptor L2 that is encoded in the genome of human.


VNN1_HUMAN Pantetheinase (sprot)

A pantetheinase that is encoded in the genome of human.


pantetheine hydrolase activity

Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + cysteamine.


pantothenate metabolic process

The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.


positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.


VNN2_HUMAN Pantetheine hydrolase VNN2 (sprot)

A pantetheine hydrolase VNN2 that is encoded in the genome of human.


CLD14_HUMAN Claudin-14 (sprot)

A claudin-14 that is encoded in the genome of human.


NPTXR_HUMAN Neuronal pentraxin receptor (sprot)

A neuronal pentraxin receptor that is encoded in the genome of human.


CBX6_HUMAN Chromobox protein homolog 6 (sprot)

A chromobox protein homolog 6 that is encoded in the genome of human.


PRAM1_HUMAN PRAME family member 1 (sprot)

A PRAME family member 1 that is encoded in the genome of human.


PRA12_HUMAN PRAME family member 12 (sprot)

A PRAME family member 12 that is encoded in the genome of human.


GTR10_HUMAN Solute carrier family 2, facilitated glucose transporter member 10 (sprot)

A solute carrier family 2, facilitated glucose transporter member 10 that is encoded in the genome of human.


negative regulation of integrin-mediated signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway.


negative regulation of connective tissue growth factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production.


artery development

The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.


negative regulation of proteoglycan biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


positive regulation of proteoglycan biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).


dehydroascorbic acid transmembrane transporter activity

Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other.


D-glucose transmembrane transporter activity

Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other.


galactose transmembrane transport

The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.


dehydroascorbic acid transport

The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C.


glucose import across plasma membrane

The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol.


NADK_HUMAN NAD kinase (sprot)

An NAD kinase that is encoded in the genome of human.


NAD+ kinase activity

Catalysis of the reaction: ATP + NAD+ = ADP + 2 H+ + NADP+.


TYDP2_HUMAN Tyrosyl-DNA phosphodiesterase 2 (sprot)

A tyrosyl-DNA phosphodiesterase 2 that is encoded in the genome of human.


tyrosyl-RNA phosphodiesterase activity

Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.


Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA.


CA105_HUMAN Uncharacterized protein C1orf105 (sprot)

An uncharacterized protein C1orf105 that is encoded in the genome of human.


SFT2B_HUMAN Vesicle transport protein SFT2B (sprot)

A vesicle transport protein SFT2B that is encoded in the genome of human.


MPC2_HUMAN Mitochondrial pyruvate carrier 2 (sprot)

A brain protein 44 that is encoded in the genome of human.


mitochondrial pyruvate transmembrane transport

The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion.


inner mitochondrial membrane protein complex

Any protein complex that is part of the inner mitochondrial membrane.


MET18_HUMAN Histidine protein methyltransferase 1 homolog (sprot)

A histidine protein methyltransferase 1 homolog that is encoded in the genome of human.


Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine.


regulation of translational elongation

Any process that modulates the frequency, rate, extent or accuracy of translational elongation.


regulation of ribosome biogenesis

Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


regulation of rRNA processing

Any process that modulates the frequency, rate or extent of rRNA processing.


ETHE1_HUMAN Persulfide dioxygenase ETHE1, mitochondrial (sprot)

A persulfide dioxygenase ETHE1, mitochondrial that is encoded in the genome of human.


sulfur dioxygenase activity

Catalysis of the reaction: sulfur + O2 + H2O = sulfite.


hydrogen sulfide metabolic process

The chemical reactions and pathways involving hydrogen sulfide, H2S.


ACSL3_HUMAN Fatty acid CoA ligase Acsl3 (sprot)

A fatty acid CoA ligase Acsl3 that is encoded in the genome of human.


medium-chain fatty acid-CoA ligase activity

Catalysis of the reaction: ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.


positive regulation of Golgi to plasma membrane protein transport

Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.


positive regulation of secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.


positive regulation of phosphatidylcholine biosynthetic process

Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process.


KLF8_HUMAN Krueppel-like factor 8 (sprot)

A krueppel-like factor 8 that is encoded in the genome of human.


RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 (sprot)

A DNA-directed RNA polymerase I subunit RPA1 that is encoded in the genome of human.


RNA polymerase I activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


negative regulation of protein localization to nucleolus

Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus.


PCNT_HUMAN Pericentrin (sprot)

A pericentrin that is encoded in the genome of human.


YETS4_HUMAN YEATS domain-containing protein 4 (sprot)

A YEATS domain-containing protein 4 that is encoded in the genome of human.


modification-dependent protein binding

Binding to a protein upon post-translation modification of the target protein.


regulation of double-strand break repair

Any process that modulates the frequency, rate or extent of double-strand break repair.


NuA4 histone acetyltransferase complex

A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).


DUS4L_HUMAN tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (sprot)

A tRNA-dihydrouridine synthase 4-like that is encoded in the genome of human.


Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) = H+ + a uracil20a in tRNA + NAD(P)H.


Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) = H+ + a uracil20b in tRNA + NAD(P)H.


tRNA dihydrouridine synthesis

The process whereby a uridine in a transfer RNA is converted to dihydrouridine.


ADCY5_HUMAN Adenylate cyclase type 5 (sprot)

An adenylate cyclase type 5 that is encoded in the genome of human.


adenylate cyclase binding

Binding to an adenylate cyclase.


G protein-coupled adenosine receptor signaling pathway

The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.


adenylate cyclase-inhibiting dopamine receptor signaling pathway

An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process.


regulation of insulin secretion involved in cellular response to glucose stimulus

Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.


ZBT11_HUMAN Zinc finger and BTB domain-containing protein 11 (sprot)

A zinc finger and BTB domain-containing protein 11 that is encoded in the genome of human.


CNOT4_HUMAN CCR4-NOT transcription complex subunit 4 (sprot)

A CCR4-NOT transcription complex subunit 4 that is encoded in the genome of human.


regulation of megakaryocyte differentiation

Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.


STABP_HUMAN STAM-binding protein (sprot)

A STAM-binding protein that is encoded in the genome of human.


deubiquitinase activity

An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.


hippocampal neuron apoptotic process

Any apoptotic process that occurs in a hippocampal neuron.


negative regulation of hippocampal neuron apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons.


NET1_HUMAN Netrin-1 (sprot)

A netrin-1 that is encoded in the genome of human.


mammary gland duct morphogenesis

The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk.


regulation of glial cell migration

Any process that modulates the frequency, rate or extent of glial cell migration.


FSTL3_HUMAN Follistatin-related protein 3 (sprot)

A follistatin-related protein 3 that is encoded in the genome of human.


activin binding

Binding to activin, a dimer of inhibin-beta subunits.


negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.


CPSF4_HUMAN Cleavage and polyadenylation specificity factor subunit 4 (sprot)

A cleavage and polyadenylation specificity factor subunit 4 that is encoded in the genome of human.


NFAC1_HUMAN Nuclear factor of activated T-cells, cytoplasmic 1 (sprot)

A nuclear factor of activated T-cells, cytoplasmic 1 that is encoded in the genome of human.


mitogen-activated protein kinase p38 binding

Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation.


skeletal muscle adaptation

Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals.


mononuclear cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell.


negative regulation of vascular associated smooth muscle cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation.


positive regulation of DNA biosynthetic process

Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.


DIRA3_HUMAN GTP-binding protein Di-Ras3 (sprot)

A GTP-binding protein Di-Ras3 that is encoded in the genome of human.


genomic imprinting

The establishment of epigenetic modifications (imprints) during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation.


NTR2_HUMAN Neurotensin receptor type 2 (sprot)

A neurotensin receptor type 2 that is encoded in the genome of human.


sensory perception

The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


VATG2_HUMAN V-type proton ATPase subunit G 2 (sprot)

A V-type proton ATPase subunit G 2 that is encoded in the genome of human.


ASML_HUMAN Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (sprot)

A probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein that is encoded in the genome of human.


O-methyltransferase activity

Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.


dTTP diphosphatase activity

Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate.


UTP diphosphatase activity

Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate.


nucleotide metabolic process

The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).


ECEL1_HUMAN Endothelin-converting enzyme-like 1 (sprot)

An endothelin-converting enzyme-like 1 that is encoded in the genome of human.


CDS2_HUMAN Phosphatidate cytidylyltransferase 2 (sprot)

A phosphatidate cytidylyltransferase 2 that is encoded in the genome of human.


Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.


The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.


EYA4_HUMAN Eyes absent homolog 4 (sprot)

An eyes absent homolog 4 that is encoded in the genome of human.


K2C75_HUMAN Keratin, type II cytoskeletal 75 (sprot)

A keratin, type II cytoskeletal 75 that is encoded in the genome of human.


CEP43_HUMAN Centrosomal protein 43 (sprot)

A centrosomal protein 43 that is encoded in the genome of human.


PPR3D_HUMAN Protein phosphatase 1 regulatory subunit 3D (sprot)

A protein phosphatase 1 regulatory subunit 3D that is encoded in the genome of human.


glycogen metabolic process

The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.


regulation of glycogen catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.


glycogen granule

Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface.


BRD1_HUMAN Bromodomain-containing protein 1 (sprot)

A bromodomain-containing protein 1 that is encoded in the genome of human.


regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).


regulation of hemopoiesis

Any process that modulates the frequency, rate or extent of hemopoiesis.


MOZ/MORF histone acetyltransferase complex

A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.


APBB3_HUMAN Amyloid-beta A4 precursor protein-binding family B member 3 (sprot)

An amyloid-beta A4 precursor protein-binding family B member 3 that is encoded in the genome of human.


RPP29_HUMAN Ribonuclease P protein subunit p29 (sprot)

A ribonuclease P protein subunit p29 that is encoded in the genome of human.


LY86_HUMAN Lymphocyte antigen 86 (sprot)

A lymphocyte antigen 86 that is encoded in the genome of human.


HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 (sprot)

An E3 ubiquitin-protein ligase HERC2 that is encoded in the genome of human.


CXL14_HUMAN C-X-C motif chemokine 14 (sprot)

A C-X-C motif chemokine 14 that is encoded in the genome of human.


RAB3D_HUMAN Ras-related protein Rab-3D (sprot)

A Ras-related protein Rab-3D that is encoded in the genome of human.


positive regulation of regulated secretory pathway

Any process that activates or increases the frequency, rate or extent of regulated secretory pathway.


zymogen granule

A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.


secretory vesicle

A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.


ERR2_HUMAN Steroid hormone receptor ERR2 (sprot)

A steroid hormone receptor ERR2 that is encoded in the genome of human.


embryonic placenta development

The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.


integrator complex

A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.


stem cell division

The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.


SNP29_HUMAN Synaptosomal-associated protein 29 (sprot)

A synaptosomal-associated protein 29 that is encoded in the genome of human.


autophagosome membrane docking

The initial attachment of an autophagosome membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.


ciliary pocket membrane

That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket).


CRTAM_HUMAN Cytotoxic and regulatory T-cell molecule (sprot)

A cytotoxic and regulatory T-cell molecule that is encoded in the genome of human.


detection of tumor cell

The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal.


positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.


regulation of T cell differentiation

Any process that modulates the frequency, rate or extent of T cell differentiation.


detection of stimulus

The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal.


lymphocyte migration into lymphoid organs

The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen.


regulation of CD8-positive, alpha-beta T cell activation

Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.


CPNE6_HUMAN Copine-6 (sprot)

A copine-6 that is encoded in the genome of human.


PM2P2_HUMAN Putative postmeiotic segregation increased 2-like protein 2 (sprot)

A putative postmeiotic segregation increased 2-like protein 2 that is encoded in the genome of human.


OXSR1_HUMAN Serine/threonine-protein kinase OSR1 (sprot)

A serine/threonine-protein kinase OSR1 that is encoded in the genome of human.


osmosensory signaling pathway

The series of molecular signals initiated in response to osmotic change.


chemokine (C-X-C motif) ligand 12 signaling pathway

The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


cellular hypotonic response

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.


GGPPS_HUMAN Geranylgeranyl pyrophosphate synthase (sprot)

A geranylgeranyl pyrophosphate synthase that is encoded in the genome of human.


dimethylallyltranstransferase activity

Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.


farnesyltranstransferase activity

Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.


geranyltranstransferase activity

Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.


geranyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of geranyl diphosphate.


geranylgeranyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate.


farnesyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of farnesyl diphosphate.


FGF19_HUMAN Fibroblast growth factor 19 (sprot)

A fibroblast growth factor 19 that is encoded in the genome of human.


negative regulation of bile acid biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


LDOC1_HUMAN Protein LDOC1 (sprot)

A protein LDOC1 that is encoded in the genome of human.


maternal process involved in parturition

A reproductive process occurring in the mother that results in birth.


SEM4F_HUMAN Semaphorin-4F (sprot)

A semaphorin-4F that is encoded in the genome of human.


RAB36_HUMAN Ras-related protein Rab-36 (sprot)

A Ras-related protein Rab-36 that is encoded in the genome of human.


HS74L_HUMAN Heat shock 70 kDa protein 4L (sprot)

A heat shock 70 kDa protein 4L that is encoded in the genome of human.


PTBP3_HUMAN Polypyrimidine tract-binding protein 3 (sprot)

A regulator of differentiation 1 that is encoded in the genome of human.


negative regulation of RNA splicing

Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing.


TBCD8_HUMAN TBC1 domain family member 8 (sprot)

A TBC1 domain family member 8 that is encoded in the genome of human.


blood circulation

The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.


IL33_HUMAN Interleukin-33 (sprot)

An interleukin-33 that is encoded in the genome of human.


positive regulation of cellular defense response

Any process that activates or increases the frequency, rate or extent of cellular defense response.


negative regulation of macrophage proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage proliferation.


positive regulation of CD86 production

Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process.


positive regulation of CD80 production

Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process.


interleukin-33 receptor binding

Binding to an interleukin-33 receptor.


negative regulation of immunoglobulin production

Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.


positive regulation of immunoglobulin production

Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.


negative regulation of leukocyte migration

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.


negative regulation of T-helper 1 type immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.


positive regulation of type 2 immune response

Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.


positive regulation of interleukin-5 production

Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.


positive regulation of MHC class I biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.


microglial cell proliferation

The expansion of a microglial cell population by cell division.


STR3N_HUMAN STARD3 N-terminal-like protein (sprot)

A STARD3 N-terminal-like protein that is encoded in the genome of human.


vesicle tethering to endoplasmic reticulum

The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.


LSM8_HUMAN U6 snRNA-associated Sm-like protein LSm8 (sprot)

A U6 snRNA-associated Sm-like protein LSm8 that is encoded in the genome of human.


U6 snRNA binding

Binding to a U6 small nuclear RNA (U6 snRNA).


Lsm2-8 complex

A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus.


ZN682_HUMAN Zinc finger protein 682 (sprot)

A zinc finger protein 682 that is encoded in the genome of human.


AP2A1_HUMAN AP-2 complex subunit alpha-1 (sprot)

An AP-2 complex subunit alpha-1 that is encoded in the genome of human.


negative regulation of hyaluronan biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.


filopodium tip

The end of a filopodium distal to the body of the cell.


clathrin coat of trans-Golgi network vesicle

A clathrin coat found on a vesicle of the trans-Golgi network.


WIZ_HUMAN Protein Wiz (sprot)

A protein Wiz that is encoded in the genome of human.


RIGI_HUMAN Antiviral innate immune response receptor RIG-I (sprot)

An antiviral innate immune response receptor RIG-I that is encoded in the genome of human.


positive regulation of myeloid dendritic cell cytokine production

Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.


regulation of type III interferon production

Any process that modulates the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.


RIG-I signaling pathway

The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.


positive regulation of response to cytokine stimulus

Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.


ZMYM6_HUMAN Zinc finger MYM-type protein 6 (sprot)

A zinc finger MYM-type protein 6 that is encoded in the genome of human.


STAU1_HUMAN Double-stranded RNA-binding protein Staufen homolog 1 (sprot)

A double-stranded RNA-binding protein Staufen homolog 1 that is encoded in the genome of human.


lncRNA-mediated post-transcriptional gene silencing

A post-transcriptional gene silencing pathway in which regulatory long noncoding RNAs (lncRNAs) elicit silencing of specific target genes, often miRNAs or mRNAs.


positive regulation by virus of viral protein levels in host cell

Any process where the infecting virus increases the levels of viral proteins in a cell.


modification of postsynaptic structure

Any process that modifies the structure of a postsynapse.


GPR75_HUMAN Probable G-protein coupled receptor 75 (sprot)

A probable G-protein coupled receptor 75 that is encoded in the genome of human.


C-C chemokine receptor activity

Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.


TTC4_HUMAN Tetratricopeptide repeat protein 4 (sprot)

A tetratricopeptide repeat protein 4 that is encoded in the genome of human.


NDST3_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (sprot)

A bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 that is encoded in the genome of human.


[heparan sulfate]-glucosamine N-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.


heparan sulfate N-deacetylase activity

Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine.


heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan.


TM50A_HUMAN Transmembrane protein 50A (sprot)

A transmembrane protein 50A that is encoded in the genome of human.


glial cell projection

A prolongation or process extending from a glial cell.


CAVN2_HUMAN Caveolae-associated protein 2 (sprot)

A caveolae-associated protein 2 that is encoded in the genome of human.


plasma membrane tubulation

A membrane tubulation process occurring in a plasma membrane.


CER1_HUMAN Cerberus (sprot)

A cerberus that is encoded in the genome of human.


growth plate cartilage chondrocyte proliferation

The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.


gastrulation

A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.


sequestering of BMP in extracellular matrix

Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.


negative regulation of mesoderm development

Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.


BAG2_HUMAN BAG family molecular chaperone regulator 2 (sprot)

A BAG family molecular chaperone regulator 2 that is encoded in the genome of human.


dendritic microtubule

Any microtubule in a dendrite, a neuron projection.


adenyl-nucleotide exchange factor activity

Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.


positive regulation of protein processing

Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.


negative regulation of ubiquitin protein ligase activity

Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.


BAG3_HUMAN BAG family molecular chaperone regulator 3 (sprot)

A BAG family molecular chaperone regulator 3 that is encoded in the genome of human.


protein transport along microtubule

The directed movement of a protein along a microtubule, mediated by motor proteins.


dynein intermediate chain binding

Binding to an intermediate chain of the dynein complex.


protein carrier chaperone

Binding to and carrying a protein between two different cellular components by moving along with the target protein.


striated muscle cell apoptotic process

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.


negative regulation of striated muscle cell apoptotic process

Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.


chaperone-mediated autophagy

The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded.


negative regulation of transcription from RNA polymerase II promoter in response to stress

Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


positive regulation of aggrephagy

Any process that activates or increases the frequency, rate or extent of aggrephagy.


M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (sprot)

A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of human.


creatine kinase activity

Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+.


positive regulation of ARF protein signal transduction

Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction.


positive regulation of focal adhesion disassembly

Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components.


DCMC_HUMAN Malonyl-CoA decarboxylase, mitochondrial (sprot)

A malonyl-CoA decarboxylase, mitochondrial that is encoded in the genome of human.


malonyl-CoA decarboxylase activity

Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2.


acetyl-CoA biosynthetic process

The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.


positive regulation of fatty acid oxidation

Any process that activates or increases the frequency, rate or extent of fatty acid oxidation.


QORL1_HUMAN Quinone oxidoreductase-like protein 1 (sprot)

A quinone oxidoreductase-like protein 1 that is encoded in the genome of human.


Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone.


quinone metabolic process

The chemical reactions and pathways involving quinone.


AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (sprot)

An apoptosis-inducing factor 1, mitochondrial that is encoded in the genome of human.


oxidoreductase activity, acting on NAD(P)H

Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


poly-ADP-D-ribose binding

Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring.


chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.


mitochondrial respiratory chain complex assembly

The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.


protein import into mitochondrial intermembrane space

The import of proteins into the space between the inner and outer mitochondrial membranes.


positive regulation of necroptotic process

Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.


CLD1_HUMAN Claudin-1 (sprot)

A claudin-1 that is encoded in the genome of human.


establishment of blood-nerve barrier

The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier.


xenobiotic transport across blood-nerve barrier

The directed movement of a xenobiotic through the blood-nerve barrier.


cellular response to lead ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.


establishment of endothelial intestinal barrier

The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.


cellular response to butyrate

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus.


CLIC3_HUMAN Chloride intracellular channel protein 3 (sprot)

A chloride intracellular channel protein 3 that is encoded in the genome of human.


EMAL2_HUMAN Echinoderm microtubule-associated protein-like 2 (sprot)

An echinoderm microtubule-associated protein-like 2 that is encoded in the genome of human.


negative regulation of microtubule polymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.


LATS1_HUMAN Serine/threonine-protein kinase LATS1 (sprot)

A serine/threonine-protein kinase LATS1 that is encoded in the genome of human.


sister chromatid segregation

The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.


inner cell mass cell fate commitment

The cell fate commitment of precursor cells that will become inner cell mass cells.


inner cell mass cellular morphogenesis

The morphogenesis of cells in the inner cell mass.


hippo signaling

The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.


cytoplasmic sequestering of protein

The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.


regulation of ubiquitin-dependent protein catabolic process

Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


GNA14_HUMAN Guanine nucleotide-binding protein subunit alpha-14 (sprot)

A guanine nucleotide-binding protein subunit alpha-14 that is encoded in the genome of human.


GLP2R_HUMAN Glucagon-like peptide 2 receptor (sprot)

A glucagon-like peptide 2 receptor that is encoded in the genome of human.


cellular response to glucagon stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.


ANGL1_HUMAN Angiopoietin-related protein 1 (sprot)

An angiopoietin-related protein 1 that is encoded in the genome of human.


GUC1C_HUMAN Guanylyl cyclase-activating protein 3 (sprot)

A guanylyl cyclase-activating protein 3 that is encoded in the genome of human.


photoreceptor disc membrane

Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.


UCP4_HUMAN Mitochondrial uncoupling protein 4 (sprot)

A mitochondrial uncoupling protein 4 that is encoded in the genome of human.


intracellular triglyceride homeostasis

A homeostatic process involved in the maintenance of a steady state level of triglyceride within a cell.


NUD14_HUMAN Uridine diphosphate glucose pyrophosphatase NUDT14 (sprot)

A uridine diphosphate glucose pyrophosphatase NUDT14 that is encoded in the genome of human.


UDP-sugar diphosphatase activity

Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate.


TSN13_HUMAN Tetraspanin-13 (sprot)

A tetraspanin-13 that is encoded in the genome of human.


regulation of calcium ion transmembrane transport

Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport.


TSN15_HUMAN Tetraspanin-15 (sprot)

A tetraspanin-15 that is encoded in the genome of human.


regulation of membrane protein ectodomain proteolysis

Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


TSN12_HUMAN Tetraspanin-12 (sprot)

A tetraspanin-12 that is encoded in the genome of human.


BPNT1_HUMAN 3'(2'),5'-bisphosphate nucleotidase 1 (sprot)

A 3'(2'),5'-bisphosphate nucleotidase 1 that is encoded in the genome of human.


Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.


SNAI1_HUMAN Zinc finger protein SNAI1 (sprot)

A zinc finger protein SNAI1 that is encoded in the genome of human.


epithelial cell migration

The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.


negative regulation of cell differentiation involved in embryonic placenta development

Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state.


left/right pattern formation

The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.


heterochromatin organization

Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin.


FADS2_HUMAN Acyl-CoA 6-desaturase (sprot)

An acyl-CoA 6-desaturase that is encoded in the genome of human.


DDAH2_HUMAN N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (sprot)

An N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 that is encoded in the genome of human.


G6B_HUMAN Megakaryocyte and platelet inhibitory receptor G6b (sprot)

A megakaryocyte and platelet inhibitory receptor G6b that is encoded in the genome of human.


LY66C_HUMAN Lymphocyte antigen 6 complex locus protein G6c (sprot)

A lymphocyte antigen 6 complex locus protein G6c that is encoded in the genome of human.


LY66D_HUMAN Lymphocyte antigen 6 complex locus protein G6d (sprot)

A lymphocyte antigen 6 complex locus protein G6d that is encoded in the genome of human.


ABHGA_HUMAN Phosphatidylserine lipase ABHD16A (sprot)

A phosphatidylserine lipase ABHD16A that is encoded in the genome of human.


phosphatidylserine catabolic process

The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.


GPAN1_HUMAN G patch domain and ankyrin repeat-containing protein 1 (sprot)

A G patch domain and ankyrin repeat-containing protein 1 that is encoded in the genome of human.


CF047_HUMAN Uncharacterized protein C6orf47 (sprot)

An uncharacterized protein C6orf47 that is encoded in the genome of human.


FRITZ_HUMAN WD repeat-containing and planar cell polarity effector protein fritz homolog (sprot)

A WD repeat-containing and planar cell polarity effector protein fritz homolog that is encoded in the genome of human.


auditory receptor cell morphogenesis

Any process that alters the size or shape of an auditory receptor cell.


regulation of embryonic cell shape

Any process that modulates the surface configuration of an embryonic cell.


septin cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins.


podocyte cell migration

The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.


regulation of ruffle assembly

Any process that modulates the frequency, rate or extent of ruffle assembly.


TXD12_HUMAN Thioredoxin domain-containing protein 12 (sprot)

A thioredoxin domain-containing protein 12 that is encoded in the genome of human.


protein-disulfide reductase (glutathione) activity

Catalysis of the reaction: 2 glutathione + protein-disulfide = glutathione disulfide+ protein-dithiol.


DLGP3_HUMAN Disks large-associated protein 3 (sprot)

A disks large-associated protein 3 that is encoded in the genome of human.


signaling

The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.


cholinergic synapse

A synapse that uses acetylcholine as a neurotransmitter.


NOE2_HUMAN Noelin-2 (sprot)

A noelin-2 that is encoded in the genome of human.


regulation of vascular associated smooth muscle cell dedifferentiation

Any process that modulates the frequency, rate or extent of vascular smooth muscle cell dedifferentiation.


TRUB2_HUMAN Pseudouridylate synthase TRUB2, mitochondrial (sprot)

A pseudouridylate synthase TRUB2, mitochondrial that is encoded in the genome of human.


positive regulation of mitochondrial translation

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


mRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.


ribonucleoprotein granule

A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.


ECD_HUMAN Protein ecdysoneless homolog (sprot)

A protein ecdysoneless that is encoded in the genome of human.


MOT3_HUMAN Monocarboxylate transporter 3 (sprot)

A monocarboxylate transporter 3 that is encoded in the genome of human.


lactate transport

The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.


OR2H2_HUMAN Olfactory receptor 2H2 (sprot)

An olfactory receptor 2H2 that is encoded in the genome of human.


mating

The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.


TTLL1_HUMAN Polyglutamylase complex subunit TTLL1 (sprot)

A polyglutamylase complex subunit TTLL1 that is encoded in the genome of human.