Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.


dihydroorotate dehydrogenase activity

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Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.


GOG8K_HUMAN Golgin subfamily A member 8K (sprot)

A protein that is a translation product of the GOLGA8K gene in human.


Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O.


MA13P_HUMAN Putative MAGE domain-containing protein MAGEA13P (sprot)


Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate.


G protein-coupled glutamate receptor binding

Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor).


proteasome core complex assembly

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The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles.


replication fork protection complex

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A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.


peptidyl-aspartic acid hydroxylation

The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid.


GTP cyclohydrolase binding

Binding to a GTP cyclohydrolase.


catenin-TCF7L2 complex

A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.


sulfite oxidase activity

Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate.


UAP1L_HUMAN UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (sprot)

A UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 that is encoded in the genome of human.


NAD(P)+ transhydrogenase activity

Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.


Okazaki fragment processing involved in mitotic DNA replication

Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication.


dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity

Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.


nuclear polyadenylation-dependent CUT catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT.


mitotic DNA replication initiation

Any DNA replication initiation involved in mitotic cell cycle DNA replication.


folic acid-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.


regulation of protein localization to membrane

Any process that modulates the frequency, rate or extent of protein localization to membrane.


actin filament bundle organization

A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.


oxytocin receptor binding

Binding to an oxytocin receptor.


KCNT1_HUMAN Potassium channel subfamily T member 1 (sprot)

A potassium channel subfamily T member 1 that is encoded in the genome of human.


A0A0G2JQ47_HUMAN Killer cell immunoglobulin-like receptor 2DS1 (trembl)


hepatocyte growth factor receptor activity

Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


U2 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U2 snRNA molecule.


A0A0G2JN01_HUMAN Killer cell immunoglobulin-like receptor, three Ig domains pseudogene 1 (trembl)


purine-specific nucleoside:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in).


IgE receptor activity

Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


tRNA-intron endonuclease activity

Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.


gonadotropin-releasing hormone receptor binding

Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.


clathrin-uncoating ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP.


histone H3-K36 dimethylation

The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone.


Noc1p-Noc2p complex

A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.


Dbf4-dependent protein kinase complex

A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.


oligosaccharide-lipid intermediate biosynthetic process

The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation.


SPD15_HUMAN Putative speedy protein E15 (sprot)


MAGE2_HUMAN Melanoma-associated antigen E2 (sprot)

A melanoma-associated antigen E2 that is encoded in the genome of human.


Golgi vesicle docking

The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane.


muscle attachment

The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).


negative cofactor 2 complex

A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.


large ribosomal subunit rRNA binding

Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.


Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA.


melanocortin receptor binding

Binding to a melanocortin receptor.


SPD17_HUMAN Putative speedy protein E17 (sprot)


adenine/guanine mispair binding

Binding to a double-stranded DNA region containing an A/G mispair.


thiosulfate transmembrane transporter activity

Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other.


FRYL_HUMAN Protein furry homolog-like (sprot)

A protein furry-like that is encoded in the genome of human.


cerebellar granular layer maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.


AG1L2_HUMAN Putative glycosyltransferase ALG1L2 (sprot)

A putative glycosyltransferase ALG1L2 that is encoded in the genome of human.


chromosome localization to nuclear envelope involved in homologous chromosome segregation

The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis.


D-lactate dehydrogenase activity

Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate.


RNA polymerase I assembly

The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex.


male meiosis cytokinesis

A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.


octopamine biosynthetic process

The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species.


TM202_HUMAN Transmembrane protein 202 (sprot)

A transmembrane protein 202 that is encoded in the genome of human.


Rix1 complex

A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes.


HDHD5_HUMAN Haloacid dehalogenase-like hydrolase domain-containing 5 (sprot)

A haloacid dehalogenase-like hydrolase domain-containing 5 that is encoded in the genome of human.


SPA13_HUMAN Putative serpin A13 (sprot)

A putative serpin A13 that is encoded in the genome of human.


INY2B_HUMAN Protein INSYN2B (sprot)

A protein INSYN2B that is encoded in the genome of human.


Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.


dense core granule priming

A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking.


S14L6_HUMAN Putative SEC14-like protein 6 (sprot)


A0A075B7B8_HUMAN Immunoglobulin heavy variable 3/OR16-12 (non-functional) (Fragment) (trembl)


U1 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U1 snRNA molecule.


sphinganine metabolic process

The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol.


negative regulation of mRNA polyadenylation

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation.


G32P1_HUMAN Putative G-protein coupled receptor GPR32P1 (sprot)


cysteinyl leukotriene receptor activity

Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine.


G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.


MROH1_HUMAN Maestro heat-like repeat-containing protein family member 1 (sprot)

A maestro heat-like repeat-containing protein family member 1 that is encoded in the genome of human.


myosin II filament disassembly

The disassembly of a bipolar filament composed of myosin II molecules.


short-chain carboxylesterase activity

Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.


negative regulation of GTP cyclohydrolase I activity

Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I.


LBHD1_HUMAN LBH domain-containing protein 1 (sprot)

A protein that is a translation product of the LBHD1 gene in human.


SEML_HUMAN Putative protein SEM1, isoform 2 (sprot)


VAS1L_HUMAN V-type proton ATPase subunit S1-like protein (sprot)

A V-type proton ATPase subunit S1-like protein that is encoded in the genome of human.


mitochondrial tRNA wobble uridine modification

The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified.


ZY11A_HUMAN Protein zyg-11 homolog A (sprot)

A protein zyg-11 homolog A that is encoded in the genome of human.


SE1L2_HUMAN Protein sel-1 homolog 2 (sprot)

A protein sel-1 homolog 2 that is encoded in the genome of human.


A0A075B7F0_HUMAN Immunoglobulin heavy variable 3/OR16-10 (non-functional) (Fragment) (trembl)


plasma membrane proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the plasma membrane.


interleukin-33 binding

Binding to interleukin-33.


PAL4F_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4F (sprot)

A protein that is a translation product of the PPIAL4F gene in human.


histone H3-K9 methylation

The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone.


F220P_HUMAN Putative protein FAM220BP (sprot)


nuclear polyadenylation-dependent snRNA catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA.


medium-chain fatty acid transport

The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.


positive regulation of somatostatin secretion

Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


laminin complex

A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes.


Mis6-Sim4 complex

A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.


clathrin-dependent endocytosis of virus by host cell

Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus.


INT6L_HUMAN Integrator complex subunit 6-like (sprot)

An integrator complex subunit 6-like that is encoded in the genome of human.


radial glia guided migration of cerebellar granule cell

The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer.


cytoplasmic translational termination

The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.


transcription factor TFIIE complex

A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH.


type 1 melanin-concentrating hormone receptor binding

Binding to a type 1 melanin-concentrating hormone receptor.


sterol delta7 reductase activity

Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol.


MA7D2_HUMAN MAP7 domain-containing protein 2 (sprot)

A MAP7 domain-containing protein 2 that is encoded in the genome of human.


ribose phosphate metabolic process

The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar.


protein localization to ciliary inversin compartment

A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment.


SG1D4_HUMAN Secretoglobin family 1D member 4 (sprot)

A secretoglobin family 1D member 4 that is encoded in the genome of human.


dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.


DPCA2_HUMAN Putative Dresden prostate carcinoma protein 2 (sprot)


amidophosphoribosyltransferase activity

Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O.


regulation of regulatory ncRNA processing

Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing.


ARH37_HUMAN Rho guanine nucleotide exchange factor 37 (sprot)

A Rho guanine nucleotide exchange factor 37 that is encoded in the genome of human.


23S rRNA (adenine(1618)-N(6))-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.


U12 snRNA binding

Binding to a U12 small nuclear RNA (U12 snRNA).


A0A3B3IRQ3_HUMAN Uncharacterized protein (trembl)


CDP-glycerol diphosphatase activity

Catalysis of the reaction: CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H+.


regulation of microtubule depolymerization

Any process that modulates the frequency, rate or extent of microtubule depolymerization.


HSFX4_HUMAN Heat shock transcription factor, X-linked member 4 (sprot)

A protein that is a translation product of the HSFX4 gene in human.


CFA97_HUMAN Cilia- and flagella-associated protein 97 (sprot)

A cilia- and flagella-associated protein 97 that is encoded in the genome of human.


dystroglycan complex

A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.


DNA replication preinitiation complex

A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.


Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.


PRA26_HUMAN Putative PRAME family member 26 (sprot)


double-stranded DNA endonuclease activity

Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks.


GOG8R_HUMAN Golgin subfamily A member 8R (sprot)

A protein that is a translation product of the GOLGA8R gene in human.


polyprenol biosynthetic process

The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.


isopentenyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids.


LRC30_HUMAN Leucine-rich repeat-containing protein 30 (sprot)

A leucine-rich repeat-containing protein 30 that is encoded in the genome of human.


negative regulation of G2/MI transition of meiotic cell cycle

Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.


RNA polymerase III assembly

The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex.


SPD16_HUMAN Putative speedy protein E16 (sprot)


Atg8 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond.


P4R3C_HUMAN Protein PPP4R3C (sprot)

A protein that is a translation product of the PPP4R3C gene in human.


extrinsic component of postsynaptic early endosome membrane

The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


steroid 7-alpha-hydroxylase activity

Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O.


meiotic joint molecule formation

The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.


DMXL1_HUMAN DmX-like protein 1 (sprot)

A DmX-like protein 1 that is encoded in the genome of human.


galanin receptor binding

Binding to a galanin receptor.


SPD14_HUMAN Putative speedy protein E14 (sprot)


TPBGL_HUMAN Trophoblast glycoprotein-like (sprot)

A trophoblast glycoprotein-like that is encoded in the genome of human.


post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5.


regulation of heterochromatin formation

Any process that modulates the frequency, rate, extent or location of heterochromatin formation.


MS4A5_HUMAN Membrane-spanning 4-domains subfamily A member 5 (sprot)

A membrane-spanning 4-domains subfamily A member 5 that is encoded in the genome of human.


sperm individualization

The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.


regulation of integrin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.


PMIS2_HUMAN Transmembrane protein PMIS2 (sprot)

A protein that is a translation product of the PMIS2 gene in human.


dermatan sulfate metabolic process

The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues.


KHDCL_HUMAN Putative KHDC1-like protein (sprot)


tRNA wobble position uridine thiolation

The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.


phosphorus-oxygen lyase activity

Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


bent DNA binding

Binding to DNA in a bent conformation.


TRAPPI protein complex

A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the core subunits of all TRAPP complexes in yeast.


response to 11-deoxycorticosterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus.


S4R3C0_HUMAN Immunoglobulin heavy variable 3/OR16-17 (non-functional) (Fragment) (trembl)


ribonuclease MRP activity

Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.


group II metabotropic glutamate receptor activity

A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.


substance P receptor binding

Binding to a substance P receptor.


LRC53_HUMAN Leucine-rich repeat-containing protein 53 (sprot)

A protein that is a translation product of the LRRC53 gene in human.


type 1 orexin receptor binding

Binding to a type 1 orexin receptor.


polytene chromosome

A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.


negative regulation of sequestering of calcium ion

Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


lipoic acid binding

Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid.


A0A0G2JPC4_HUMAN Killer cell immunoglobulin-like receptor (trembl)


H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH.


interleukin-9 binding

Binding to interleukin-9.


DNA topoisomerase activity

Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.


telomere localization

Any process in which a telomere is transported to, and/or maintained in, a specific location.


transverse filament

A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.


DNA ligase III-XRCC1 complex

A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair.


SPA11_HUMAN Serpin A11 (sprot)

A serpin A11 that is encoded in the genome of human.


exopolyphosphatase activity

Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.


MROH6_HUMAN Maestro heat-like repeat-containing protein family member 6 (sprot)

A protein that is a translation product of the MROH6 gene in human.


neural fold bending

The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse.


MRO2A_HUMAN Maestro heat-like repeat-containing protein family member 2A (sprot)

A maestro heat-like repeat-containing protein family member 2A that is encoded in the genome of human.


imidazolonepropionase activity

Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+.


SCP2D_HUMAN SCP2 sterol-binding domain-containing protein 1 (sprot)

An SCP2 sterol-binding domain-containing protein 1 that is encoded in the genome of human.


SPD13_HUMAN Putative speedy protein E13 (sprot)


U5 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U5 snRNA molecule.


secondary metabolic process

The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.


DC122_HUMAN DDB1- and CUL4-associated factor 12-like protein 2 (sprot)

A DDB1- and CUL4-associated factor 12-like protein 2 that is encoded in the genome of human.


AN32C_HUMAN Putative uncharacterized protein ANP32CP (sprot)

An acidic leucine-rich nuclear phosphoprotein 32 family member C that is encoded in the genome of human.


FB5L3_HUMAN Putative fatty acid-binding protein 5-like protein 3 (sprot)


actin cortical patch localization

Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells.


TIGD2_HUMAN Tigger transposable element-derived protein 2 (sprot)

A tigger transposable element-derived protein 2 that is encoded in the genome of human.


perisynaptic extracellular matrix

The portion of the extracellular matrix that lies within the perisynaptic space.


Noc2p-Noc3p complex

A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.


N-terminal peptidyl-serine methylation

The methylation of the N-terminal serine of proteins.


sarcosine catabolic process

The chemical reactions and pathways resulting in the breakdown of sarcosine.


mitochondrial DNA-directed RNA polymerase complex

A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form.


CRIS2_HUMAN Cysteine-rich secretory protein 2 (sprot)

A cysteine-rich secretory protein 2 that is encoded in the genome of human.


cone matrix sheath

A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments.


Sec62/Sec63 complex

A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.


nonfunctional rRNA decay

An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system.


striated muscle dense body

A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.


nucleus-vacuole junction

An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p.


regulation of skeletal muscle cell proliferation

Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.


CH088_HUMAN Uncharacterized protein C8orf88 (sprot)

A protein that is a translation product of the C8orf88 gene in human.


monopolar spindle attachment to meiosis I kinetochore

The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs.


negative regulation of ribosome biogenesis

Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


tRNA threonylcarbamoyladenosine metabolic process

The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.


SH24B_HUMAN SH2 domain-containing protein 4B (sprot)

An SH2 domain-containing protein 4B that is encoded in the genome of human.


nuclear mRNA surveillance of mRNA 3'-end processing

The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus.


nuclear polyadenylation-dependent antisense transcript catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript.


Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage.


slow-twitch skeletal muscle fiber contraction

A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.


WF10A_HUMAN WAP four-disulfide core domain protein 10A (sprot)

A WAP four-disulfide core domain protein 10A that is encoded in the genome of human.


TEX26_HUMAN Testis-expressed protein 26 (sprot)

A testis-expressed protein 26 that is encoded in the genome of human.


cupric reductase activity

Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.


lateral element assembly

The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements.


LRC69_HUMAN Leucine-rich repeat-containing protein 69 (sprot)

A leucine-rich repeat-containing protein 69 that is encoded in the genome of human.


A0A376A8Z9_HUMAN KIR2DS5 protein (trembl)


glyoxalase III activity

Catalysis of the reaction: methylglyoxal + H2O = D-lactate.


glucosamine 6-phosphate N-acetyltransferase activity

Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+.


Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.


SCML1_HUMAN Sex comb on midleg-like protein 1 (sprot)

A sex comb on midleg-like protein 1 that is encoded in the genome of human.


dUDP biosynthetic process

The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate).


assembly of large subunit precursor of preribosome

The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome.


dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.


negative regulation of serine-type peptidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity.


D5 dopamine receptor binding

Binding to a D5 dopamine receptor.


mannose-1-phosphate guanylyltransferase (GTP) activity

Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.


A0A075B7D8_HUMAN Immunoglobulin heavy variable 3/OR15-7 (pseudogene) (Fragment) (trembl)


NADPH-adrenodoxin reductase activity

Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.


histone H3K79 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein.


ABRAL_HUMAN Costars family protein ABRACL (sprot)

A costars family protein ABRACL that is encoded in the genome of human.


rRNA cytidine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.


A0A0G2JLM5_HUMAN Killer cell immunoglobulin-like receptor 2DS5 (trembl)


ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.


response to dehydroepiandrosterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus.


RMXL3_HUMAN RNA-binding motif protein, X-linked-like-3 (sprot)

An RNA-binding motif protein, X-linked-like-3 that is encoded in the genome of human.


site of polarized growth

Any part of a cell where non-isotropic growth takes place.


regulation of nervous system development

Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.


DC4L1_HUMAN DDB1- and CUL4-associated factor 4-like protein 1 (sprot)

A DDB1- and CUL4-associated factor 4-like protein 1 that is encoded in the genome of human.


AMERL_HUMAN AMMECR1-like protein (sprot)

An AMMECR1-like protein that is encoded in the genome of human.


bub1-bub3 complex

Protein complex that associates with the kinetochores.


negative regulation of gastric acid secretion

Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


fatty acid synthase activity

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.


parathyroid hormone receptor binding

Binding to a parathyroid hormone receptor.


nitrate transmembrane transporter activity

Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other.


thyrotropin-releasing hormone activity

The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


protein methylesterase activity

Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol.


CXCR4 chemokine receptor binding

Binding to a CXCR4 chemokine receptor.


fructosamine metabolic process

The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.


peptidyl-histidine methylation, to form tele-methylhistidine

The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine).


termination of RNA polymerase III transcription

A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues.


histone H3 deacetylation

The modification of histone H3 by the removal of one or more acetyl groups.


A0A0G2JNF4_HUMAN Killer cell immunoglobulin-like receptor, two Ig domains pseudogene 1 (trembl)


RNA polymerase III preinitiation complex assembly

The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter.


pyrimidine nucleoside transport

The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


meiotic spindle midzone

The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap.


SGE2P_HUMAN Putative SAGE1-like protein (sprot)


MB3L4_HUMAN Putative methyl-CpG-binding domain protein 3-like 4 (sprot)


hydroxypyruvate isomerase activity

Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate.


lytic vacuole

A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.


Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A).


determination of ventral identity

The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


apelin receptor activity

Combining with the peptide apelin to initiate a change in cell activity.


heterotrimeric G-protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex.


Golgi to plasma membrane transport vesicle

A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.


neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol.


D-lactate dehydrogenase (cytochrome) activity

Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.


meiotic chromosome separation

The process in which chromosomes are physically detached from each other during meiosis.


adenine biosynthetic process

The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.


putrescine biosynthetic process from arginine, using agmatinase

The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step.


serine O-acyltransferase activity

Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule.


mitotic actomyosin contractile ring assembly actin filament organization

Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly.


A0A3B3IRS2_HUMAN Uncharacterized protein (trembl)


Catalysis of the reaction: carboxymethyluridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine.


GTP 3',8'-cyclase activity

Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.


Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).


peptidyl-proline hydroxylation to 3-hydroxy-L-proline

The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase.


Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.


RNA lariat debranching enzyme activator activity

Binds to and increases the activity of an RNA lariat debranching enzyme.


sarcosine metabolic process

The chemical reactions and pathways involving sarcosine.


arginine catabolic process to proline via ornithine

The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine.


propionate metabolic process, methylmalonyl pathway

The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway.


PRT1B_HUMAN Proline rich transmembrane protein 1B (sprot)

A protein that is a translation product of the PRRT1B gene in human.


meiotic spindle assembly checkpoint signaling

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle.


SPE2B_HUMAN Speedy protein E2B (sprot)

A protein that is a translation product of the SPDYE2B gene in human.


molybdenum incorporation into molybdenum-molybdopterin complex

The incorporation of molybdenum into a molybdenum-molybdopterin complex.


mitochondrial double-strand break repair via homologous recombination

The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences.


DNA replication proofreading

Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.


chemokine production

The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


growth hormone receptor activity

Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


structural constituent of synapse

The action of a molecule that contributes to the structural integrity of a synapse.


regulation of muscle system process

Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.


cyclic pyranopterin monophosphate synthase activity

Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.


positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.


interleukin-9 receptor binding

Binding to an interleukin-9 receptor.


ribonuclease P complex

A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs.


F135A_HUMAN Protein FAM135A (sprot)

A protein FAM135A that is encoded in the genome of human.


Rpd3L-Expanded complex

A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.


farnesyl diphosphate metabolic process

The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.


mitotic DNA replication

Any nuclear DNA replication that is involved in a mitotic cell cycle.


A0A0G2JNG1_HUMAN Killer cell immunoglobulin-like receptor 2DS5 (trembl)


NPS3B_HUMAN Protein NipSnap homolog 3B (sprot)

A protein NipSnap homolog 3B that is encoded in the genome of human.


axonemal basal plate

Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure.


CALL4_HUMAN Calmodulin-like protein 4 (sprot)

A calmodulin-like protein 4 that is encoded in the genome of human.


PAS complex

A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.


SPDE3_HUMAN Speedy protein E3 (sprot)

A speedy protein E3 that is encoded in the genome of human.


SNUFL_HUMAN Putative SNURF-like protein (sprot)


cytotoxic T cell differentiation

The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.


general transcription initiation factor activity

A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.


TBC26_HUMAN TBC1 domain family member 26 (sprot)

A TBC1 domain family member 26 that is encoded in the genome of human.


tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate

A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans.


ubiquinone-6 biosynthetic process

The chemical reactions and pathways resulting in the formation of ubiquinone-6.


Swi5-Swi2 complex

A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching.


adenine binding

Binding to adenine, a purine base.


The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.


Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A).


N-terminal peptidyl-proline methylation

The methylation of the N-terminal proline of proteins.


metabolite repair

A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites.


mitochondrial proton-transporting ATP synthase, stator stalk

One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.


uracil binding

Binding to uracil.


histone H4-K8 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.


germ-line stem cell division

The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.


SWT1_HUMAN Transcriptional protein SWT1 (sprot)

A transcriptional protein SWT1 that is encoded in the genome of human.


QCR6L_HUMAN Cytochrome b-c1 complex subunit 6-like, mitochondrial (sprot)

A protein that is a translation product of the UQCRHL gene in human.


ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate

The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate.


microtubule-based transport

A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.


negative regulation of GTP binding

Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding.


adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation.


presynaptic cytoskeleton

The portion of the cytoskeleton contained within the presynapse.


epinephrine secretion

The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system.


histone H3-K14 acetylation

The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.


alkylbase DNA N-glycosylase activity

Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.


neuromedin U receptor binding

Binding to one or more specific sites on a neuromedin U receptor.


acireductone dioxygenase [iron(II)-requiring] activity

Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+.


transcription open complex formation at RNA polymerase II promoter

Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.


oxytocin receptor activity

Combining with oxytocin to initiate a change in cell activity.


adenosine kinase activity

Catalysis of the reaction: ATP + adenosine = ADP + AMP.


D-xylose catabolic process

The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide.


glycine biosynthetic process from serine

The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine.


nucleotide-excision repair, preincision complex assembly

The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage.


A0A0G2JP20_HUMAN PRAME family member 9 (trembl)


taste receptor binding

Binding to a taste receptor.


LRC28_HUMAN Leucine-rich repeat-containing protein 28 (sprot)

A leucine-rich repeat-containing protein 28 that is encoded in the genome of human.


alpha-amino acid metabolic process

The chemical reactions and pathways involving an alpha-amino acid.


nuclear pre-replicative complex

A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.


brassinosteroid biosynthetic process

The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects.


Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP.


T178B_HUMAN Transmembrane protein 178B (sprot)

A transmembrane protein 178B that is encoded in the genome of human.


intermediate filament-based process

Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins.


fast-twitch skeletal muscle fiber contraction

A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability.


nuclear pore transmembrane ring

A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.


IFM10_HUMAN Interferon-induced transmembrane protein 10 (sprot)

An interferon-induced transmembrane protein 10 that is encoded in the genome of human.


A0A087WYE8_HUMAN Immunoglobulin heavy variable 1/OR21-1 (non-functional) (Fragment) (trembl)


SPDE1_HUMAN Speedy protein E1 (sprot)

A speedy protein E1 that is encoded in the genome of human.


riboflavin binding

Binding to riboflavin.


CO040_HUMAN UPF0235 protein C15orf40 (sprot)

A UPF0235 protein C15orf40 that is encoded in the genome of human.


MWP complex

A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin.


HEAT4_HUMAN HEAT repeat-containing protein 4 (sprot)

A HEAT repeat-containing protein 4 that is encoded in the genome of human.


meiotic DNA double-strand break processing

The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis.


glycolipid translocation

The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


MROH5_HUMAN Maestro heat-like repeat family member 5 (sprot)


diphthine methylesterase activity

Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol.


RNA polymerase III core binding

Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.


maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II

Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.


GDP-mannose hydrolase activity

Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate.


monounsaturated fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid.


NHSL1_HUMAN NHS-like protein 1 (sprot)

An NHS-like protein 1 that is encoded in the genome of human.


nuclear migration along microtubule

The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.


mitochondrial coenzyme A transmembrane transport

The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion.


phosphoglycerate dehydrogenase activity

Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.


dTDP-glucose 4,6-dehydratase activity

Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.


Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate.


cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity

Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP.


oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group.


CTP reductase activity

Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


TTP reductase activity

Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor

Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin.


UDP reductase activity

Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin.


ADP reductase activity

Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin.


CDP reductase activity

Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin.


Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.


DNA-(apurinic or apyrimidinic site) endonuclease, initiator methionine removed form (human)

A DNA-(apurinic or apyrimidinic site) endonuclease (human) that has had the initiator methionine removed. UniProtKB:P27695, 2-318.


eukaryotic translation initiation factor 4E phosphorylated 1 (human)

A eukaryotic translation initiation factor 4E (human) that has been phosphorylated on the residue at the position equivalent to Ser-53 of the amino acid sequence represented by UniProtKB:P06730-1. Example: UniProtKB:P06730-1, Ser-53, MOD:00046.


An Axin that is a translation product of the human AXIN1 gene or a 1:1 ortholog thereof.


Axin-1 isoform 1 (human)

An Axin-1 isoform 1 that is encoded in the genome of human.


Axin-1 ubiquitinated 1 (human)

An Axin-1 (human) that has been ubiquitinated on the residue at the position equivalent to Lys-501 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Lys-501, MOD:01148.


Axin-1 ADP-ribosylated form (human)

An Axin-1 (human) that includes at least one ADP-ribosylated residue. UniProtKB:O15169, MOD:00752.


Axin-1 isoform 2 (human)

An Axin-1 isoform 2 that is encoded in the genome of human.


Axin-1 phosphorylated 1 (human)

An Axin-1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-481, and phosphoserine at positions 486 and 493 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Thr-481, MOD:00047|Ser-486/Ser-493, MOD:00046.


Axin-1 ADP-ribosylated and ubiquitinated form (human)

An Axin-1 (human) that includes at least one ADP-ribosylated residue and at least one ubiquitinated lysine. UniProtKB:O15169, MOD:00752|MOD:01148.


zinc-alpha-2-glycoprotein N-glycosylated 33 (human)

A zinc-alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-128 of the amino acid sequence represented by UniProtKB:P25311-1, in which the glycan composition is represented by GlyTouCan:G60923RB. Example: UniProtKB:P25311-1, Asn-128, MOD:00160~GNO:G60923RB.


encapsulin nanocompartment

Intracellular non-membrane bound organelle, consisting of proteinaceous polyhedral shells that encapsulate enzymes, protecting the contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only one protein, and has only a few proteins inside. Shells about vary from about 25-42 nm in diameter. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla.


serine/threonine-protein kinase VRK2 isoform h4 (human)

A serine/threonine-protein kinase VRK2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86Y07-4.


prolargin O-glycosylated 6 (human)

A prolargin (human) that has been O-glycosylated at the residue equivalent to Thr-56 of the amino acid sequence represented by UniProtKB:P51888-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P51888-1, Thr-56, MOD:00005~GNO:G53434XO.


potassium voltage-gated channel subfamily H member 5 isoform 3 (human)

A voltage-gated potassium channel KCNH5 isoform 3 that is encoded in the genome of human.


Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2.


mucin-1 O-glycosylated 9 (human)

A mucin-1 (human) that has been O-glycosylated at the residue equivalent to Thr-919 of the amino acid sequence represented by UniProtKB:P15941-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P15941-1, Thr-919, MOD:00005~GNO:G58001LT.


ETS domain-containing transcription factor ERF isoform h2 (human)

An ETS domain-containing transcription factor ERF (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P50548-2.


heat shock 70 kDa protein 4 isoform h2 (human)

A heat shock 70 kDa protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34932-2.


HSPH protein

An Hsp70 family chaperone that has its ATP-binding and substrate-binding domains separated by a linker domain of over 100 amino acids. Proteins in this class function generally as nucleotide exchange factors for cytosolic Hsp70s.


heat shock protein 105 kDa isoform Beta (human)

A heat shock protein 105 kDa isoform 2 that is encoded in the genome of human.


heat shock protein 105 kDa isoform Alpha (human)

A heat shock protein 105 kDa isoform 1 that is encoded in the genome of human.


heat shock 70 kDa protein 4L

An HSPH protein that is a translation product of the human HSPA4L gene or a 1:1 ortholog thereof.


heat shock 70 kDa protein 4 isoform 1 (human)

A heat shock 70 kDa protein 4 isoform 1 that is encoded in the genome of human.


heat shock protein 105 kDa isoform h4 (human)

A heat shock protein 105 kDa (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-4.


heat shock protein 105 kDa isoform h3 (human)

A heat shock protein 105 kDa (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-3.


heat shock protein 105 kDa

An HSPH protein that is a translation product of the human HSPH1 gene or a 1:1 ortholog thereof.


heat shock 70 kDa protein 4

An HSPH protein that is a translation product of the human HSPA4 gene or a 1:1 ortholog thereof.


14-3-3 protein gamma isoform 1 (human)

A 14-3-3 protein gamma isoform 1 that is encoded in the genome of human.


Ral guanine nucleotide dissociation stimulator-like 3 isoform h1 (human)

A Ral guanine nucleotide dissociation stimulator-like 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3MIN7-1.


tRNA transmembrane transporter activity

Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other.


adiponectin O-glycosylated 1 (human)

An adiponectin (human) that has been O-glycosylated at the residue equivalent to Thr-21 of the amino acid sequence represented by UniProtKB:Q15848-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q15848-1, Thr-21, MOD:00005~GNO:G53434XO.


DnaJ homolog subfamily C member 12 isoform a (human)

A DnaJ homolog subfamily C member 12 isoform 1 that is encoded in the genome of human.


alpha-N-acetylgalactosaminidase N-glycosylated 30 (human)

An alpha-N-acetylgalactosaminidase (human) that has been N-glycosylated at the residue equivalent to Asn-177 of the amino acid sequence represented by UniProtKB:P17050-1, in which the glycan structure is represented by GlyTouCan:G45359RY. Example: UniProtKB:P17050-1, Asn-177, MOD:00160~GNO:G45359RY.


UDP-glucuronosyltransferase 2B15 N-glycosylated 1 (human)

A UDP-glucuronosyltransferase 2B15 (human) that has been N-glycosylated at the residue equivalent to Asn-316 of the amino acid sequence represented by UniProtKB:P54855-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P54855-1, Asn-316, MOD:00160~GNO:G06247RL.


BCAS3 microtubule associated cell migration factor isoform h4 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-8.


BCAS3 microtubule associated cell migration factor isoform h1 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-2.


BCAS3 microtubule associated cell migration factor isoform 2 (human)

A BCAS3 microtubule associated cell migration factor isoform 1 that is encoded in the genome of human.


BCAS3 microtubule associated cell migration factor isoform h5 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-7.


BCAS3 microtubule associated cell migration factor isoform h3 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-3.


BCAS3 microtubule associated cell migration factor isoform h6 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-6.


heat shock factor 2-binding protein isoform h2 (human)

A heat shock factor 2-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75031-2.


heat shock factor 2-binding protein isoform h1 (human)

A heat shock factor 2-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75031-1.


T-cell surface glycoprotein CD4 N-glycosylated 23 (human)

A T-cell surface glycoprotein CD4 (human) that has been N-glycosylated at the residue equivalent to Asn-296 of the amino acid sequence represented by UniProtKB:P01730-1, in which the glycan structure is represented by GlyTouCan:G65890UA. Example: UniProtKB:P01730-1, Asn-296, MOD:00160~GNO:G65890UA.


indole catabolic process

The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


indole biosynthetic process

The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


peptide chain release factor 1-like, mitochondrial isoform h3 (human)

A peptide chain release factor 1-like, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGC7-3.


specification of animal organ axis polarity

The process in which the polarity of an animal organ axis is specified.


ATP-binding cassette sub-family A member 9 isoform h3 (human)

An ATP-binding cassette sub-family A member 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUA7-3.


neogenin isoform h2 (human)

A neogenin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92859-2.


excitatory amino acid transporter 4 isoform h1 (human)

An excitatory amino acid transporter 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48664-1.


mating-type a-factor pheromone receptor activity

Combining with the mating-type a-factor pheromone to initiate a change in cell activity.


nuclear envelope integral membrane protein 2 isoform h1 (human)

A nuclear envelope integral membrane protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A6NFY4-1.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h2 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-2.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3 that is encoded in the genome of human.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h1 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-1.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h4 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-4.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase phosphorylated form (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that includes at least one phosphorylated residue. UniProtKB:Q99640, MOD:00696.


lymphoid-specific helicase isoform h3 (human)

A lymphoid-specific helicase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRZ9-3.


A cyclin-A that is a translation product of the human CCNA1 gene or a 1:1 ortholog thereof.


cyclin-A1 ubiquitinated form (human)

A cyclin-A1 (human) that includes at least one ubiquitinated lysine. UniProtKB:P78396, MOD:01148.


cyclin-A1 isoform h1 (human)

A cyclin-A1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78396-1.


cyclin-A1 isoform h2 (human)

A cyclin-A1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78396-2.


cyclin-A1 isoform 3 (human)

A cyclin-A1 isoform 3 that is encoded in the genome of human.


dynein regulatory complex subunit 2 isoform h2 (human)

A dynein regulatory complex subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IXS2-2.


dynein regulatory complex subunit 2 isoform h1 (human)

A dynein regulatory complex subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IXS2-1.


membrane-spanning 4-domains subfamily A member 13 isoform h3 (human)

A membrane-spanning 4-domains subfamily A member 13 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5J8X5-3.


hedgehog-interacting protein, signal peptide removed form (human)

A hedgehog-interacting protein (human) that has had the signal peptide removed. UniProtKB:Q96QV1, 18-700.


inactive ADP-ribosyltransferase ARH2 isoform h1 (human)

An inactive ADP-ribosyltransferase ARH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NDY3-1.


inactive ADP-ribosyltransferase ARH2

A protein that is a translation product of the human ADPRHL1 gene or a 1:1 ortholog thereof.


inactive ADP-ribosyltransferase ARH2 isoform h2 (human)

An inactive ADP-ribosyltransferase ARH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NDY3-2.


prostate-specific antigen N-glycosylated 5 (human)

A prostate-specific antigen (human) that has been N-glycosylated at the residue equivalent to Asn-69 of the amino acid sequence represented by UniProtKB:P07288-1, in which the glycan composition is represented by GlyTouCan:G03574QJ. Example: UniProtKB:P07288-1, Asn-69, MOD:00160~GNO:G03574QJ.


platelet-derived growth factor receptor-like protein isoform 1 (human)

A platelet-derived growth factor receptor-like protein isoform 1 that is encoded in the genome of human.


dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

A protein that is a translation product of the human RPN1 gene or a 1:1 ortholog thereof.


dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, signal peptide removed form (human)

A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (human) that has had the signal peptide removed. UniProtKB:P04843, 24-607.


Catalysis of the reaction: H+ + NADH + O2 + quinolin-4-ol = H2O + NAD+ + quinoline-3,4-diol.


PTB-containing, cubilin and LRP1-interacting protein isoform h3 (human)

A PTB-containing, cubilin and LRP1-interacting protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z2X4-3.


PTB-containing, cubilin and LRP1-interacting protein isoform 4 (human)

A PTB-containing, cubilin and LRP1-interacting protein isoform 4 that is encoded in the genome of human.


PTB-containing, cubilin and LRP1-interacting protein isoform h1 (human)

A PTB-containing, cubilin and LRP1-interacting protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z2X4-1.


PTB-containing, cubilin and LRP1-interacting protein isoform h2 (human)

A PTB-containing, cubilin and LRP1-interacting protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z2X4-2.


Ras-specific guanine nucleotide-releasing factor RalGPS2 isoform h3 (human)

A Ras-specific guanine nucleotide-releasing factor RalGPS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86X27-3.


POU domain, class 3, transcription factor 2 isoform hN-OCT 5A (human)

A POU domain, class 3, transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20265-2.


POU domain, class 3, transcription factor 2

A protein that is a translation product of the human POU3F2 gene or a 1:1 ortholog thereof.


POU domain, class 3, transcription factor 2 isoform hN-OCT 3 (human)

A POU domain, class 3, transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20265-1.


POU domain, class 3, transcription factor 2 isoform hN-OCT 5B (human)

A POU domain, class 3, transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20265-3.


testis-specific serine/threonine-protein kinase 3 isoform 1 (human)

A testis-specific serine/threonine-protein kinase 3 isoform 1 that is encoded in the genome of human.


N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity

Catalysis of the reaction: H2O + N(8)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2.


effector-mediated suppression of host pattern-triggered immunity signaling

A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants.


effector-mediated suppression of host innate immune response

A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


effector-mediated suppression of host pattern-triggered immunity

A process mediated by a molecule secreted by a symbiont that results in the suppression of the innate immune response of the host organism via recognition of a microbe-associated molecular pattern. The innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction.


A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.


negative regulation of proline import across plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of proline import into cell.


positive regulation of myofibroblast cell apoptotic process

Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process.


serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1 (human)

A serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1 that is encoded in the genome of human.


ADP-ribosylation factor GTPase-activating protein 1 isoform h2 (human)

An ADP-ribosylation factor GTPase-activating protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N6T3-2.


WD repeat-containing protein 89

A protein that is a translation product of the human WDR89 gene or a 1:1 ortholog thereof.


dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform h2 (human)

A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04844-2.


positive regulation of thyroid gland epithelial cell proliferation

Any process that activates or increases the frequency, rate or extent of thyroid gland epithelial cell proliferation.


positive regulation of epithelial cell proliferation involved in lung bud dilation

Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially.


positive regulation of acinar cell proliferation

Any process that activates or increases the frequency, rate or extent of acinar cell proliferation.


zinc finger FYVE domain-containing protein 9 isoform 2 (human)

A zinc finger FYVE domain-containing protein 9 isoform 2 that is encoded in the genome of human.


dynein regulatory complex subunit 2

A protein that is a translation product of the human CCDC65 gene or a 1:1 ortholog thereof.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform h1 (human)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75251-1.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

A protein that is a translation product of the human NDUFS7 gene or a 1:1 ortholog thereof.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, transit peptide removed form (human)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that has had the transit peptide removed. UniProtKB:O75251, 39-213.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform h2 (human)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75251-2.


mismatch repair endonuclease PMS2

A protein that is a translation product of the human PMS2 gene or a 1:1 ortholog thereof.


mismatch repair endonuclease PMS2 isoform h2 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-2.


mismatch repair endonuclease PMS2 isoform h3 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-3.


mismatch repair endonuclease PMS2 isoform h4 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-4.


mismatch repair endonuclease PMS2 isoform h1 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-1.


ceramide synthase 5 isoform h2 (human)

A ceramide synthase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N5B7-2.


structural constituent of ascospore wall

The action of a molecule that contributes to the structural integrity of an ascospore wall.


integrin beta-8 isoform h1 (human)

An integrin beta-8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26012-1.


histone H3.3, initiator methionine removed monomethylated 3 (human)

A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Arg-27 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-27, MOD:00414.


histone-lysine N-methyltransferase MECOM isoform 7 (human)

A histone-lysine N-methyltransferase MECOM isoform 7 that is encoded in the genome of human.


homeobox protein Hox-B1 isoform h1 (human)

A homeobox protein Hox-B1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14653-1.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h1 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-1.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h3 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-3.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h4 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-4.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h2 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-2.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h7 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-7.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h6 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-6.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h5 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-5.


coiled-coil domain-containing protein 107 isoform h2 (human)

A coiled-coil domain-containing protein 107 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WV48-2.


DnaJ homolog subfamily C member 8 isoform 1 (human)

A DnaJ homolog subfamily C member 8 isoform 1 that is encoded in the genome of human.


DnaJ homolog subfamily C member 8, initiator methionine removed form (human)

A DnaJ homolog subfamily C member 8 (human) that has had the initiator methionine removed. UniProtKB:O75937, 2-253.


soluble scavenger receptor cysteine-rich domain-containing protein SSC5D O-glycosylated 10 (human)

A soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (human) that has been O-glycosylated at the residue equivalent to Thr-1462 of the amino acid sequence represented by UniProtKB:A1L4H1-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:A1L4H1-1, Thr-1462, MOD:00005~GNO:G58001LT.


transmembrane protein 161B isoform h2 (human)

A transmembrane protein 161B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NDZ6-2.


FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h1 (human)

A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-1.


FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h2 (human)

A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-2.