plasma membrane proton-transporting ATP synthase, central stalk

One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species.


single-stranded DNA-dependent ATP-dependent DNA helicase complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A protein complex that possesses single-stranded DNA-dependent DNA helicase activity.


Scrib-APC complex

A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation.


SCF-Hrt3/Pof7 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is Hrt3 in S. cerevisiae (Pof7 in S. pombe).


beta-galactosidase complex

A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species.


nuclear proteasome core complex, alpha-subunit complex

The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell.


Vps55/Vps68 complex

A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins.


multivesicular body HOPS complex

Any HOPS complex that is part of a multivesicular body membrane.


mitochondrial respiratory chain complex I, membrane segment

The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix.


copper ion transmembrane transporter complex

A protein complex which is capable of copper ion transmembrane transporter activity.


alpha9-beta1 integrin-ADAM3 complex

A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3.


interferon regulatory factor 3-interferon regulatory factor 5 complex

An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5.


Cvt complex

A protein complex that is involved in the Cvt pathway. In budding yeast, the Cvt complex consists of multimers of preApe1p.


DASH complex

A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability.


SCF-Saf1/Pof9 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is Saf1 in S. cerevisiae (Pof9 in S. pombe).


A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin.


SCF-Rcy1/Pof6 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is Rcy1 in S. cerevisiae (Pof6 in S. pombe).


Kv4.2-KChIP1 channel complex

A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2.


endobrevin-SNAP-25-syntaxin-1a complex

A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof).


D-amino-acid dehydrogenase complex

A protein complex that possesses D-amino-acid dehydrogenase activity.


divisome complex

A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells.


ammonium transmembrane transporter complex

High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other.


B875 antenna complex

Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm.


bronchus basement membrane

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A basement membrane that is part of a bronchus.


interleukin-4 receptor complex

A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor.


Mst2 histone acetyltransferase complex

A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6.


integrin alphav-beta1 complex

An integrin complex that comprises one alphav subunit and one beta1 subunit.


dimethyl sulfoxide reductase complex

An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide.


RNA polymerase II termination complex

A conserved protein complex capable of 5'-3' exoribonuclease activity. It is able to promote RNA polymerase II (RNAPII) transcription termination by degrading pre-mRNA from the newly formed 5' phosphorylated end.


meiotic septin complex

A heterooligomeric septin complex that acts during meiotic cell division.


Cbp3p-Cbp6 complex

A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly.


inaD signaling complex

A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.


chloroplast photosystem II

An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.


SCF-Das1 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is Das1 in S. cerevisiae.


Lid2 complex

A protein complex involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid2, Ash2, Jmj3, Snt2, and Sdc1.


chloroplast isoamylase complex

A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized.


bI4 intron splicing complex

A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing.


tRNA (m2G10) methyltransferase complex

A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p.


nuclear membrane complex Bqt3-Bqt4

A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4.


plasma membrane-derived thylakoid photosystem II

A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.


tRNA-specific adenosine-34 deaminase complex

A protein complex that possesses tRNA-specific adenosine-34 deaminase activity. In eukaryotes the complex is a heterodimer; the subunits are known as Tad2p and Tad3p in yeasts and Adat2 and Adat3 in human.


collagen type XX trimer

A collagen homotrimer of alpha1(XX) chains.


trachea basement membrane

A basement membrane that is part of a trachea.


starch utilization system complex

A bacterial cell envelope-associated multiprotein system, which binds and degrades starch.


A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof).


large ribosomal subunit pre-assembly complex

A protein complex that assists early maturation of nascent 60S ribosomal subunits. The complex interacts with the large ribosomal subunit rRNA via one of the components (Urb2 in S. cerevisiae) and requires a RNA helicase (Dbp6 in S. cerevisiae).


replication inhibiting complex

A protein complex that inhibits multiple events of replication initiation during one replication cycle.


A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420.


Ost-alpha/Ost-beta complex

A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity.


phosphatidylinositol 3-kinase complex, class I

A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast.


homodimeric serine palmitoyltransferase complex

A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine.


MCM core complex

A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated.


IgD B cell receptor complex

An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.


proton-transporting ATP synthase, central stalk

One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis.


MBF transcription complex

A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p.


A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin.


anchoring collagen complex

Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures.


chloroplast proton-transporting ATP synthase complex

A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation.


mBAF complex

A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof.


nuclear proteasome core complex, beta-subunit complex

The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell.


anthranilate synthase complex

A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine.


ModE complex

A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism.


mitotic checkpoint complex, CDC20-MAD2 subcomplex

A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20.


superoxide dismutase copper chaperone complex

A protein complex which is capable of superoxide dismutase copper chaperone activity.


alpha6-beta4 integrin-Shc-Grb2 complex

A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2.


myosin IV complex

A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV.


chloroplast large ribosomal subunit

The large subunit of a ribosome contained within a chloroplast.


INA complex

A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p.


glycoprotein complex

A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds.


Clr6 histone deacetylase complex I''

A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3.


EmrE multidrug transporter complex

A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer.


DNA helicase complex

A protein complex that possesses DNA helicase activity.


plastid-encoded plastid RNA polymerase complex

An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition.


Ddb1-Ckn1 complex

A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.


syntaxin-6-syntaxin-16-Vti1a complex

A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof).


chloroplast proton-transporting ATP synthase complex, catalytic core CF(1)

The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits.


laminin-522 complex

A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains.


alpha9-beta1 integrin-ADAM12 complex

A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12.


nuclear exosome focus

An nuclear body involved in nuclear mRNA surveilllance. Contains at least Mmi1, or an ortholog of it, and the nuclear exosome.


SCF-Ucc1 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is YLR224W in S. cerevisiae.


DNA polymerase III, proofreading complex

A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity.


photosystem I

A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation).


polyphosphate kinase complex

A protein complex that possesses polyphosphate kinase activity.


Grb2-Shc complex

A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway.


chaperonin ATPase complex

Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts.


Slit-Robo signaling complex

A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate.


A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin.


myosin XII complex

A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil.


endosomal scaffold complex

A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling.


mitochondrial electron transfer flavoprotein complex

A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system.


Nsk1-Dlc1 complex

A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation.


enzyme activator complex

A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active.


hemidesmosome associated protein complex

Any protein complex that is part of or has some part in a hemidesmosome.


A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV.


Tic complex

The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane.


A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters.


type IV secretion system complex

A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s).


endoplasmic reticulum protein-containing complex

A protein complex that is part of an endoplasmic reticulum.


plastid mRNA editing complex

An mRNA editing complex found in a plastid.


SRF-myogenin-E12 complex

A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.


MsbA transporter complex

An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD).


alphaIIb-beta3 integrin-CIB complex

A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin.


PTEX complex

A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components.


raps-insc complex

Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2).


ferredoxin hydrogenase complex

An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances.


pre-replicative complex

A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.


plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)

The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species.


rixosome complex

A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans.


H3 histone acetyltransferase complex

A multisubunit complex that catalyzes the acetylation of histone H3.


alpha9-beta1 integrin-ADAM9 complex

A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9.


aspartate carbamoyltransferase complex

A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides.


synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex

A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof).


UBR1-RAD6 ubiquitin ligase complex

A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.


Tpg-containing telomere binding complex

A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species.


DNA methyltransferase complex

A protein complex that possesses DNA methyltransferase activity.


acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex

A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis.


MUB1-RAD6-UBR2 ubiquitin ligase complex

A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme.


DNA replication factor C core complex

A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37.


PSII associated light-harvesting complex II

Protein-pigment complex associated with photosystem II.


nucleoplasmic THO complex

The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits.


TAM protein secretion complex

A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane.


DnaA-DiaA complex

A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA.


nuclear exosome targeting complex

A protein-containing complex that functions with the RNA exosome and contributes to the degradation of abberant transcripts.


photosystem II

A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center.


plasma membrane respiratory chain complex I

A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species.


isocitrate dehydrogenase complex (NAD+)

Complex that possesses isocitrate dehydrogenase (NAD+) activity.


Lsm-containing SMN-Sm protein complex

An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA.


myosin VI complex

A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.


DNA polymerase III, core complex

The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities.


Kir2 inward rectifier potassium channel complex

A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells.


core TFIIH complex portion of NEF3 complex

The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3).


U11 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U11, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U11 snRNP, most of which remain associated with the U11 snRNA both while the U11 snRNP is free or assembled into a series of spliceosomal complexes.


glycine reductase complex

Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C.


iNOS-S100A8/A9 complex

A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine.


contractile vacuole pore

Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium.


A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.


RNA polymerase IV transcription regulator complex

A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV.


syndecan-syntenin-ALIX complex

An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery.


HDA1 complex

A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p.


CENP-A containing chromatin

The specialized chromatin located in the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment.


alpha6-beta4 integrin-Fyn complex

A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn.


monopolin complex

A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits.


network-forming collagen trimer

A collagen trimer that forms networks.


left posteriolateral flagellum

A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the left anterior boundary of the lateral shield and the left lateral region of the funis before exiting at the left lateral region of the cell body.


TFIIIC-TOP1-SUB1 complex

A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III.


S100A9 complex

A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility.


I(KACh) inward rectifier potassium channel complex

An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G protein-coupled receptor signaling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits.


nucleotide-excision repair factor 4 complex

One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p.


ER membrane insertion complex

A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast.


PUMA-BCL-xl complex

A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


spitzenkorper

Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments.


Bam protein complex

Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex.


serotonin receptor complex

A protein complex that is capable of serotonin receptor activity.


MECO complex

A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II.


toxin-antitoxin complex

A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon.


cytosolic pyruvate dehydrogenase complex

Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.


mitochondrial respiratory chain complex IV pre-assembly complex

A protein complex that contributes to and regulates mitochondrial respiratory chain complex IV (COX) formation. It acts by regulating mitochondrial COX1 translation and by promoting the assembly of COX components.


transcription factor TFIIIC1 complex

A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity.


actomyosin, myosin complex part

The myosin part of any complex of actin, myosin, and accessory proteins.


collagen type XXVIII trimer

A collagen homotrimer of alpha1(XXVIII) chains.


[Ni-Fe] hydrogenase complex

A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer.


alpha5-beta1 integrin-tissue transglutaminase complex

A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase.


separase-securin complex

A protein complex that includes separase (a protease which cleaves cohesin as part of chromosome separation) and securin, a protease inhibitor. Chromosome separation is inhibited until securin is degraded by the Anaphase Promoting Complex (APC).


sodium ion-transporting V-type ATPase complex

A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis.


Delta1 complex

A protein complex that consists of homodimer of the Notch ligand Delta1.


ERBB4:ERBB2 complex

A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.


cargo receptor complex

Any protein complex that is part of a membrane and which functions as a cargo receptor.


cytosolic creatine kinase complex

A dimeric protein complex having creatine kinase activity.


SCF-Pof5 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is Pof5 in S. pombe (YDR306C in S. cerevisiae).


integrin alphaD-beta2 complex

An integrin complex that comprises one alphaD subunit and one beta2 subunit.


RNA polymerase IV transcription repressor complex

A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter.


myosin XVII complex

A myosin complex containing one or more class XVII myosin heavy chains and associated light chains.


A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.


Kv4.2-KChIP4 channel complex

A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2.


alpha4-beta1 integrin-CD82 complex

A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family.


A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin.


sigma factor antagonist complex

A protein complex which is capable of sigma factor antagonist activity.


nucleotide-excision repair, DNA damage recognition complex

A protein complex that is capable of identifying lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex.


methane monooxygenase complex

A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized.


new spindle pole body SIN signaling complex

A SIN signaling complex associated with the new mitotic spindle pole body during anaphase and characterized by the presence activated (GTP bound) GTPase (Spg1 in fission yeast) to activate SIN signaling.


IgE immunoglobulin complex, circulating

A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


chloroplast ribulose bisphosphate carboxylase complex

A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana.


auxin efflux carrier complex

The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell.


plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex

A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate.


SOD1-calcineurin complex

A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1.


G-protein alpha(o)-synembrin complex

A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein.


alphaPDGFR-SHP-2 complex

A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.


alpha3-beta1 integrin-basigin complex

A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin.


alpha6-beta4 integrin-laminin 5 complex

A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5.


fatty-acyl-CoA synthase complex

A protein complex that possesses fatty-acyl-CoA synthase activity.


anterior limiting lamina of cornea

A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane.


glycolate oxidase complex

An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN).


plasma membrane proton-transporting ATP synthase complex

A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species.


A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src.


G-protein alpha(i)1-synembrin complex

A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein.


TRAIL death-inducing signaling complex

A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor.


efflux pump complex

A protein complex that is capable of efflux transmembrane transporter activity.


carbamoyl-phosphate synthase complex

A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.


BIM-BCL-xl complex

A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


alphav-beta3 integrin-collagen alpha3(VI) complex

A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen.


Vma12-Vma22 assembly complex

A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p.


plasma membrane respiratory chain complex II

A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species.


A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2).


alphaV-beta6 integrin-TGFbeta-3 complex

A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3).


vacuolar transporter chaperone complex

A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p.


small ribosomal subunit processing complex

A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. The complex has endonuclease activity, it interacts with the small ribosomal subunit pre-rRNA and cleave it it to produce the mature 18S (or small ribosomal subunit) rRNA. In S. cerevisiae it is composed of Rcl1p and Bms1p.


eif4e-cup complex

A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo.


alpha9-beta1 integrin-VEGF-A complex

A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A.


mitochondrial creatine kinase complex

An octomeric protein complex having creatine kinase activity.


fatty acid beta-oxidation multienzyme complex

A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT).


integrin alpha6-beta1 complex

An integrin complex that comprises one alpha6 subunit and one beta1 subunit.


alpha6-beta1 integrin-CD151 complex

A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151.


ribulose bisphosphate carboxylase complex

A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate.


Tor2-Mei2-Ste11 complex

A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast.


heterochromatin domain

A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me).


cyanelle ribonuclease P complex

A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.


BCL-2 complex

A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators.


calprotectin complex

A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways.


ERBB4-ERBB3 complex

A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission.


SCF-Dia2/Pof3 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe).


Cdc50p-Drs2p complex

A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome.


type II polyketide synthase complex

A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction.


PSI associated light-harvesting complex I, LHCIa subcomplex

A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm.


9+2 non-motile cilium

A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).


plastid acetate CoA-transferase complex

An acetate CoA-transferase complex located in the stroma of a plastid.


A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1).


insulin control element activator complex

Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription.


H-gal-GP complex

A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus.


Kv4.3-DPP10 channel complex

A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3.


chloroplast outer membrane translocon

The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner.


molybdenum-iron nitrogenase complex

An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer.


Rpd3S complex

A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species).


laminin-6 complex

A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains.


cytoplasmic SCF ubiquitin ligase complex

A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).


RasGAP-Fyn-Lyn-Yes complex

A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation.


laminin-5B complex

A laminin complex composed of alpha3B, beta3 and gamma2 polypeptide chains.


Y-shaped link

A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium.


A protein complex that enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).


interleukin-9 receptor complex

A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins.


Par3-APC-KIF3A complex

A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity.


Rpd3L complex

A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a two copies of catalytic histone deacetylase subunit (S. pombe Clr6/ S. cerevisiae Rpd3p), an Sds-3 family protein (S. pombe /S. cerevisiae Sds3(p) ), two copies of SIN3 family co-repressor (S. pombe Pst1/ S. cerevisiae Sin3p, a WD repeat protein/ histone chaperone (S. pombe Prw1/ S. cerevisiae Ume1p), and a zf- PHD finger ( S. pombe Png2/ S. cerevisiae Pho23p), plus 4 additional subunits, and associated factors.


respiratory chain complex I

Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex.


radial spoke neck

The radial spoke neck is a complex that connects the spoke stalk to the head.


DnaB-DnaC-Rep-PriC complex

A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired.


light-activated voltage-gated calcium channel complex

A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus.


2-iminoacetate synthase complex

A protein complex which is capable of 2-iminoacetate synthase activity.


methanophenazine reducing hydrogenase complex

A protein complex which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine. This typically consists of three polypeptides.


PSII associated light-harvesting complex II, core complex

The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center.


Ecsit-NDUFAF1 complex

Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed.


CUE1-UBC7 ubiquitin-conjugating enzyme complex

A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1.


intercalary heterochromatin

Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes.


1,3-beta-D-glucan synthase complex

A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.


Kv4.1-DPP10 channel complex

A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1.


PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex

A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides.


SCF-Met30/Pof1 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe).


procollagen-proline 4-dioxygenase complex, alpha(I) type

A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline).


Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate.


A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK.


BAD-BCL-xl complex

A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


NOXA-BCL-xl complex

A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


interleukin-35 complex

A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space.


APC-IQGAP complex

A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.


nucleocytoplasmic transport complex

Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores.


phosphatidylinositol phosphate phosphatase complex

A protein complex which is capable of phosphatidylinositol phosphate phosphatase activity.


A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.


alpha1-beta1 integrin-tissue transglutaminase complex

A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase.


nitrogenase complex

An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen.


iRhom2/ADAM17 sheddase complex

A complex consisting of ADAM17 in complex with regulatory iRhoms and FERM domain containing proteins.


SCF-YLR352W ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is YLR352W in S. cerevisiae.


glutamate synthase complex (NADH)

A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.


MPT synthase complex

A heterodimeric protein complex which catalyses sulfur transfer from the sulfur carrier subunit of MPT synthase to precursor Z to synthesize MPT as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved.


Kv4.1-DPP6 channel complex

A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1.


high-affinity iron exporter complex

A protein complex which transports ferrous iron (Fe(III) or Fe3+) ions from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment.


glutamate-tRNA ligase complex

An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu).


methyl coenzyme M reductase complex

A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis.


formyl-methanofuran dehydrogenase (molybdenum enzyme) complex

A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis.


Grb2-SHP-2 complex

A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway.


A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof).


organellar ribosome

A ribosome contained within a subcellular membrane-bounded organelle.


protein acetyltransferase complex

A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule.


U4atac/U6atac snRNP

A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4atac and U6atac, a heptameric ring of Sm proteins associated with U4atac, the Lsm2-8 heptameric ring complex associated with U6atac, as well as several proteins that are unique to the U4atac snRNP or U6atac snRNPs, some of which remain associated with the U4atac/U6atac snRNA both while the U4atac snRNP is free or assembled into a series of spliceosomal complexes.


A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2.


histamine-gated chloride channel complex

A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts.


A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin.


cytosolic proteasome core complex, alpha-subunit complex

The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex.


A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other.


collagen network

A supramolecular complex that consists of collagen triple helices associated to form a network.


H-NS-Cnu complex

A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes.


RAD52-ERCC4-ERCC1 complex

A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein.


extracellular isoamylase complex

A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space.


ADA complex

A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex.


NPHP complex

A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways.


polarisome

Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.


myosin XVIII complex

A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain.


Gemin3-Gemin4-Gemin5 complex

A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly.


NVT complex

A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1.


Pi Mi complex

A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis.


DNA polymerase complex

A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA.


subtelomeric heterochromatin

Heterochromatin that is located adjacent to the telomere, and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3).


neurotransmitter receptor complex

Any protein complex that is capable of functioning as a neurotransmitter receptor.


right anterior flagellum

A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the right anterior basal body, extends laterally through the cytoplasm, crosses the left anterior axoneme, and exits as a membrane-bound flagellum on the anterior right side of the cell.


IgA immunoglobulin complex, circulating

A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


APC-IQGAP1-Rac1 complex

A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.


enterobactin synthetase complex

A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway.


sucrase-isomaltase complex

A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities.


cytosolic proteasome regulatory particle

A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex.


alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex

A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib.


3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex

A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate.


mitochondrial respiratory chain complex I, peripheral segment

The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix.


mitochondrial glutamate synthase complex (NADH)

A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.


nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.


RGS6-DNMT1-DMAP1 complex

A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1.


ATP-dependent citrate lyase complex

A protein complex that catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA.


anaerobic ribonucleoside-triphosphate reductase complex

An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit.


A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin.


RNA polymerase V transcription repressor complex

A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter.


alphaV-beta3 integrin-laminin alpha-4 complex

A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4.


chloroplast small ribosomal subunit

The small subunit of a ribosome contained within a chloroplast.


alpha4-beta1 integrin-JAM2 complex

A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2.


respiratory chain complex II

A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.


MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.


protein C inhibitor-acrosin complex

A heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin.


extracellular ferritin complex

A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains.


type I protein secretion system complex

A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space.


ESCRT IV complex

An ESCRT complex that has AAA-ATPase activity and is involved in ESCRT-mediated intralumenal vesicle formation and the final stages of cytokinesis. The complex catalyzes disassembly of the ESCRT III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1.


CSK-GAP-A.p62 complex

A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation.


acid phosphatase complex

A protein complex which is capable of acid phosphatase activity.


light-harvesting complex, core complex

Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria.


INO80-type complex

A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair.


Myo2p-Vac17p-Vac8p transport complex

A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p.


alpha6-beta1 integrin-CYR61 complex

A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis.


respiratory chain complex

Any protein complex that is part of a respiratory chain.


alpha4-beta1 integrin-CD53 complex

A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family.


U4atac/U6atac x U5 tri-snRNP complex

A spliceosomal snRNP complex that is formed by the association of the U4atac/U6atac and U5 snRNPs.


SCF-Ctf13 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is Ctf13 in S. cerevisiae.


Descemet's membrane

A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP].


ciliary centrin arm

A rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules.


SCF-Cdc4 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is Cdc4 in S. cerevisiae.


plastid small ribosomal subunit

The smaller of the two subunits of a plastid ribosome.


DPS complex

A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22.


alpha6-beta4 integrin-CD151 complex

A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151.


TACC/TOG complex

A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase.


MAML3-RBP-Jkappa-ICN4 complex

A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.


titin-telethonin complex

A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils.


IscS-TusA complex

A heterotetrameric protein complex involved in the sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions. In E. coli it consists of a central IscS dimer with the two TusA protomers bound to one of the IscS units each via persulfide (-SSH) groups.


interferon regulatory factor 5 complex

An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5.


dystrobrevin complex

A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex.


ferritin complex

A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain.


NuA3b histone acetyltransferase complex

A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p.


Ste12p-Dig1p-Dig2p complex

A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae.


PSI associated light-harvesting complex I

Protein-pigment complex associated with photosystem I.


alphaIIb-beta3 integrin-talin complex

A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin.


dosage compensation complex

A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes.


heterotetrameric decaprenyl diphosphate synthase complex

A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1.


cytoplasmic origin of replication recognition complex

A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm.


Kv4.2-DPP6 channel complex

A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2.


chloroplast ribosome

A ribosome contained within a chloroplast.


B800-850 antenna complex

Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.


creatine kinase complex

A protein complex having creatine kinase activity.


actin capping protein of dynactin complex

A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex.


S100A8 complex

A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4).


fumarate reductase complex

A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)).


alpha2-beta1 integrin-CD47 complex

A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47.


alpha4-beta1 integrin-CD47 complex

A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47.


low-density lipoprotein receptor complex

A plasma membrane protein complex capable of low-density lipoprotein particle receptor activity. It may also bind xenobiotic toxins and deliver them into the cell via endocytosis. While most substrates get degraded via the endosome the receptor is recycled to the plasma membrane. It may also act as a transducer of intracellular signal pathways and often acts in corporation with other cell-surface receptors.


condensed chromatin of inactivated sex chromosome

A condensed form of chromatin that is associated with an inactivated sex chromosome and which is responsible for its inactivation.


cytosolic proteasome core complex

The core complex of a proteasome located in the cytosol of a cell.


protein-DNA ISRE complex

A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA.


counting factor complex

A secreted multiprotein complex composed of 4 proteins, regulating group size during aggregation in cooperative development. An example of this complex is found in Dictyostelium discoideum.


Isw1a complex

An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p.


activated SUMO-E1 ligase complex

A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins.


M/G1 phase-specific MADS box-forkhead transcription factor complex

A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2.


photosystem II antenna complex

The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs).


phosphatidylinositol 3-kinase complex, class II

A phosphatidylinositol 3-kinase complex that contains a catalytic subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme and one or more adaptor proteins. There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast.


ATP-independent citrate lyase complex

Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity. This enzyme has only been found in bacteria.


TOC-TIC supercomplex I

The protein transport macromolecular complex of the chloroplast membrane that interacts with the precursor proteins and contains components of both the outer membrane and inner membrane complexes containing at least Toc75, Toc159, Toc34 and Tic110.


A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity.


ERMES complex

A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.


cytosolic oxoglutarate dehydrogenase complex

A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).


platelet-derived growth factor receptor-ligand complex

A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes.


metallochaperone complex

A protein complex which is capable of metallochaperone activity.


taurine dioxygenase complex

A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD.


viral integration complex

A nucleoprotein complex containing viral genetic material and the viral integrase, required for genome integration into the host's genome. May contain other proteins.


plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)

All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins.


interleukin-10 receptor complex

A protein complex that binds interleukin-10 (IL-10) and that consists of, at a minimum, a dimeric interleukin, an alpha and a beta chain as well as optional additional kinase subunits. The alpha chain binds IL-10 with high affinity and subsequently binds the common beta receptor chain that forms part of multiple interleukin receptors.


interleukin-20 receptor complex

A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits.


SsuD-SsuE complex

A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation.


SCF-Skp2 ubiquitin ligase complex

An SCF ubiquitin ligase complex in which the F-box protein is Skp2 in S. cerevisiae.


CD20-Lck-Fyn complex

A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn.


Smp focus

A DNA-binding ribonucleoprotein complex that contains a lncRNA complementary to the bound chromosomal locus and is involved in the tethering homologous chromosomes together during chromosome pairing at meiotic prophase I.


nephron tubule basement membrane

A basement membrane that is part of a nephron tubule.


MAML2-RBP-Jkappa-ICN3 complex

A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.


amyloplast ADPG pyrophosphorylase complex

An ADPG pyrophosphorylase complex found in the amyloplast.


synapsis initiation complex

A SUMO-E3 ligase complex capable of promoting synapsis, the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase.


nodal receptor complex

A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell.


laminin-12 complex

A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains.


protein-lipid-RNA complex

A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other.


esBAF complex

An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF complexes never contains ACTL6B/BAF53B, ARID1B/BAF250B, SMARCA2/BRM, SMARCC2/BAF170 or SMARCD3/BAF60C but contains PHF10/BAF45A, DPF2/BAF45D and possibly one of BCL7A/B/C.


collagen type XVIII trimer

A collagen homotrimer of alpha1(XVIII) chains.


RNA polymerase I upstream activating factor complex

A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.


H4/H2A histone acetyltransferase complex

A multisubunit complex that catalyzes the acetylation of histones H4 and H2A.


BID-BCL-xl complex

A heterodimeric protein complex consisting of BID and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


radial spoke base 3

The short portion of the radial spoke 3 (RS3 )that is directly anchored to the A microtubule of an axonemal microtubule doublet.


Cbf1-Met4-Met28 complex

A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation.


magnesium-dependent protein serine/threonine phosphatase complex

An intracellular enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase.


alpha9-beta1 integrin-VEGF-C complex

A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C.


A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule.


IgM immunoglobulin complex, circulating

A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph.


A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.


Holliday junction helicase complex

A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA.


NarGHI complex

A heterotrimeric protein complex with iron-sulfur and molybdenum cofactors that functions as a terminal reductase in electron transport pathways that operate during anaerobic nitrate respiration. In E. coli electrons are passed from the FdnGHI complex to the NarGHI complex via menoquinone and menaquinol. Within NarGHI, electrons are passed from the two heme molecules in the NarI subunit down a Fe-S cluster chain in the NarH and NarG subunits to the Molybdenum cofactor, Mo-bisMGD, in the NarG subunit.


iron-sulfur cluster transfer complex

A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor).


alpha3-beta1 integrin-CD63 complex

A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63.


myosin phosphatase complex

An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin. Composed of a PP1 catalytic subunit (PP1c/PPP1CB) and a myosin phosphatase targeting subunit (MYPT1/PPP1R12A).


cytosolic proteasome regulatory particle, lid subcomplex

The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.


alphaM-beta2 integrin-CD63 complex

A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family.


bursicon neuropeptide hormone complex

A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits.


MIH complex

A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins.


DNA recombinase mediator complex

A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange.


mitochondrial proton-transporting ATP synthase, central stalk

One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis.


alphaV-beta3 integrin-EGFR complex

A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor.


HICS complex

A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins.


IgG immunoglobulin complex, circulating

A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


BIM-BCL-2 complex

A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.


ISWI-type complex

Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair.


alphaV-beta3 integrin-gelsolin complex

A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin.


A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.


A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof).


DnaA-L2 complex

A protein complex that inhibits unwinding of DNA at the origin of replication and assembly of the pre-primosome. In E. coli, this complex is composed of DnaA and of the ribosomal protein L2.


cysteine synthase complex

Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A.


A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.


transforming growth factor beta activated kinase 1 complex

A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits).


Bre1-Rad6 ubiquitin ligase complex

A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis.