dendritic cell differentiation

The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.


DDAH1_HUMAN N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (sprot)

An N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 that is encoded in the genome of human.


dimethylargininase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.


citrulline metabolic process

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.


regulation of systemic arterial blood pressure

The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.


arginine catabolic process

The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


nitric oxide mediated signal transduction

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.


negative regulation of cellular response to hypoxia

Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia.


RECQ4_HUMAN ATP-dependent DNA helicase Q4 (sprot)

An ATP-dependent DNA helicase Q4 that is encoded in the genome of human.


3'-5' DNA helicase activity

Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.


bubble DNA binding

Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA.


telomeric D-loop binding

Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus.


DNA/DNA annealing activity

An activity that faciliates the formation of a complementary double-stranded DNA molecule.


telomeric D-loop disassembly

A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus.


RECQ5_HUMAN ATP-dependent DNA helicase Q5 (sprot)

An ATP-dependent DNA helicase Q5 that is encoded in the genome of human.


RNA polymerase II complex binding

Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.


chromosome separation

The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).


cellular response to camptothecin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus.


cellular response to ketone

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus.


replication-born double-strand break repair via sister chromatid exchange

The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.


mitotic DNA-templated DNA replication

A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle.


transcription preinitiation complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.


RMP_HUMAN Unconventional prefoldin RPB5 interactor 1 (sprot)

An unconventional prefoldin RPB5 interactor 1 that is encoded in the genome of human.


negative regulation of phosphatase activity

Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.


B3GA3_HUMAN Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (sprot)

A galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 that is encoded in the genome of human.


chondroitin sulfate proteoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


dermatan sulfate proteoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.


Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.


positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.


ST17B_HUMAN Serine/threonine-protein kinase 17B (sprot)

A serine/threonine-protein kinase 17B that is encoded in the genome of human.


ECM2_HUMAN Extracellular matrix protein 2 (sprot)

An extracellular matrix protein 2 that is encoded in the genome of human.


interstitial matrix

A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens.


LY6H_HUMAN Lymphocyte antigen 6H (sprot)

A lymphocyte antigen 6H that is encoded in the genome of human.


MTA2_HUMAN Metastasis-associated protein MTA2 (sprot)

A metastasis-associated protein MTA2 that is encoded in the genome of human.


regulation of fibroblast migration

Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.


regulation of cell fate specification

Any process that mediates the adoption of a specific fate by a cell.


regulation of stem cell differentiation

Any process that modulates the frequency, rate or extent of stem cell differentiation.


DPM2_HUMAN Dolichol phosphate-mannose biosynthesis regulatory protein (sprot)

A dolichol phosphate-mannose biosynthesis regulatory protein that is encoded in the genome of human.


An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.


AQP8_HUMAN Aquaporin-8 (sprot)

An aquaporin-8 that is encoded in the genome of human.


ammonium transmembrane transporter activity

Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.


methylammonium channel activity

Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2.


urea transport

The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.


methylammonium transport

The directed movement of methylammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


transepithelial water transport

The directed movement of water (H2O) from one side of an epithelium to the other.


ammonium transmembrane transport

The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+.


methylammonium transmembrane transport

The process in which methylammonium is transported across a membrane.


hydrogen peroxide transmembrane transport

The process in which hydrogen peroxide is transported across a membrane.


ammonium import across plasma membrane

The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol.


smooth endoplasmic reticulum

The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.


intracellular canaliculus

An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates.


CNTN5_HUMAN Contactin-5 (sprot)

A contactin-5 that is encoded in the genome of human.


UBP1_HUMAN Ubiquitin carboxyl-terminal hydrolase 1 (sprot)

A ubiquitin carboxyl-terminal hydrolase 1 that is encoded in the genome of human.


The removal of the ubiquitin group from a monoubiquitinated protein.


positive regulation of error-prone translesion synthesis

Any process that activates or increases the frequency, rate or extent of error-prone translesion synthesis.


AL1A2_HUMAN Retinal dehydrogenase 2 (sprot)

A retinal dehydrogenase 2 that is encoded in the genome of human.


3-chloroallyl aldehyde dehydrogenase activity

Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.


retinal binding

Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.


retinoic acid biosynthetic process

The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.


vitamin A metabolic process

The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene.


midgut development

The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.


determination of bilateral symmetry

The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.


response to cytokine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.


ureter maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.


retinal metabolic process

The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.


9-cis-retinoic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative.


embryonic digestive tract development

The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.


cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.


retinoic acid receptor signaling pathway involved in somitogenesis

The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis.


regulation of vascular endothelial cell proliferation

Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation.


STK10_HUMAN Serine/threonine-protein kinase 10 (sprot)

A serine/threonine-protein kinase 10 that is encoded in the genome of human.


lymphocyte aggregation

The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules.


regulation of lymphocyte migration

Any process that modulates the frequency, rate or extent of lymphocyte migration.


ACL6B_HUMAN Actin-like protein 6B (sprot)

An actin-like protein 6B that is encoded in the genome of human.


RSC-type complex

A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining.


GBAF complex

A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM.


KPCD3_HUMAN Serine/threonine-protein kinase D3 (sprot)

A serine/threonine-protein kinase D3 that is encoded in the genome of human.


protein kinase C activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.


GFPT2_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (sprot)

A glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 that is encoded in the genome of human.


glutamine-fructose-6-phosphate transaminase (isomerizing) activity

Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.


carbohydrate derivative binding

Binding to a carbohydrate derivative.


The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


energy reserve metabolic process

The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.


RGS11_HUMAN Regulator of G-protein signaling 11 (sprot)

A regulator of G-protein signaling 11 that is encoded in the genome of human.


TPPP_HUMAN Tubulin polymerization-promoting protein (sprot)

A tubulin polymerization-promoting protein that is encoded in the genome of human.


microtubule bundle

An arrangement of closely apposed microtubules running parallel to each other.


microtubule nucleator activity

The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly.


oligodendrocyte development

The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.


astral microtubule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.


positive regulation of protein polymerization

Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.


myelin assembly

The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.


microtubule nucleation by microtubule organizing center

The 'de novo' formation of a microtubule, mediated by the microtubule organizing center.


negative regulation of tubulin deacetylation

Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.


postsynaptic Golgi apparatus

The network of the Golgi apparatus structures located within the postsynapse.


BAIP3_HUMAN BAI1-associated protein 3 (sprot)

A BAI1-associated protein 3 that is encoded in the genome of human.


positive regulation of neurotransmitter secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.


regulation of dense core granule exocytosis

Any process that modulates the frequency, rate or extent of dense core granule exocytosis.


dense core granule maturation

Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.


SLIT2_HUMAN Slit homolog 2 protein (sprot)

A slit homolog 2 protein that is encoded in the genome of human.


laminin-1 binding

Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.


proteoglycan binding

Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


negative regulation of leukocyte chemotaxis

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.


negative regulation of lamellipodium assembly

Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.


negative regulation of smooth muscle cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.


chemorepulsion involved in postnatal olfactory bulb interneuron migration

The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration.


corticospinal neuron axon guidance through spinal cord

The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues.


induction of negative chemotaxis

Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical.


negative regulation of small GTPase mediated signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.


cellular response to heparin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.


negative regulation of smooth muscle cell chemotaxis

Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis.


negative regulation of mononuclear cell migration

Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.


negative regulation of neutrophil chemotaxis

Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


negative regulation of retinal ganglion cell axon guidance

Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.


ATG12_HUMAN Ubiquitin-like protein ATG12 (sprot)

A ubiquitin-like protein ATG12 that is encoded in the genome of human.


regulation of autophagosome maturation

Any process that modulates the frequency, rate or extent of autophagosome maturation.


positive regulation of viral translation

Any process that activates or increases the frequency, rate or extent of viral translation.


Atg12-Atg5-Atg16 complex

A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p.


transferase complex

A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).


NOL4_HUMAN Nucleolar protein 4 (sprot)

A nucleolar protein 4 that is encoded in the genome of human.


LTN1_HUMAN E3 ubiquitin-protein ligase listerin (sprot)

An E3 ubiquitin-protein ligase listerin that is encoded in the genome of human.


AT10B_HUMAN Phospholipid-transporting ATPase VB (sprot)

A phospholipid-transporting ATPase VB that is encoded in the genome of human.


lysosomal membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.


TOM70_HUMAN Mitochondrial import receptor subunit TOM70 (sprot)

A mitochondrial import receptor subunit TOM70 that is encoded in the genome of human.


mitochondrion targeting sequence binding

Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion.


protein import into mitochondrial matrix

The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.


negative regulation of cell growth involved in cardiac muscle cell development

Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.


response to thyroxine

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.


mitochondrial outer membrane translocase complex

A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments.


PKHG5_HUMAN Pleckstrin homology domain-containing family G member 5 (sprot)

A pleckstrin homology domain-containing family G member 5 that is encoded in the genome of human.


IPO13_HUMAN Importin-13 (sprot)

An importin-13 that is encoded in the genome of human.


DDHD2_HUMAN Phospholipase DDHD2 (sprot)

A phospholipase DDHD2 that is encoded in the genome of human.


triglyceride catabolic process

The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.


MYO1D_HUMAN Unconventional myosin-Id (sprot)

A myosin-Id that is encoded in the genome of human.


cellular localization

A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.


early endosome to recycling endosome transport

The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes.


axolemma

The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.


TOX4_HUMAN TOX high mobility group box family member 4 (sprot)

A TOX high mobility group box family member 4 that is encoded in the genome of human.


RHBT1_HUMAN Rho-related BTB domain-containing protein 1 (sprot)

A Rho-related BTB domain-containing protein 1 that is encoded in the genome of human.


DEND_HUMAN Dendrin (sprot)

A dendrin that is encoded in the genome of human.


MICA2_HUMAN [F-actin]-monooxygenase MICAL2 (sprot)

An [F-actin]-monooxygenase MICAL2 that is encoded in the genome of human.


sulfur oxidation

The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur.


actin filament depolymerization

Disassembly of actin filaments by the removal of actin monomers from a filament.


SC24D_HUMAN Protein transport protein Sec24D (sprot)

A protein transport protein Sec24D that is encoded in the genome of human.


COPII-coated vesicle cargo loading

The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi.


NFASC_HUMAN Neurofascin (sprot)

A neurofascin that is encoded in the genome of human.


ST65G_HUMAN STAGA complex 65 subunit gamma (sprot)

A STAGA complex 65 subunit gamma that is encoded in the genome of human.


maintenance of protein location in nucleus

Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.


FCSD2_HUMAN F-BAR and double SH3 domains protein 2 (sprot)

An F-BAR and double SH3 domains protein 2 that is encoded in the genome of human.


positive regulation of Arp2/3 complex-mediated actin nucleation

Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation.


stereocilium shaft

The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle.


UFL1_HUMAN E3 UFM1-protein ligase 1 (sprot)

An E3 UFM1-protein ligase 1 that is encoded in the genome of human.


protein ufmylation

Covalent attachment of the ubiquitin-like protein UFM1 to another protein.


UFM1 ligase activity

Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S = X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate.


regulation of intracellular estrogen receptor signaling pathway

Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


positive regulation of glial cell proliferation

Any process that activates or increases the rate or extent of glial cell proliferation.


reticulophagy

The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.


response to L-glutamate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus.


negative regulation of IRE1-mediated unfolded protein response

Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response.


protein K69-linked ufmylation

A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.


SRBS2_HUMAN Sorbin and SH3 domain-containing protein 2 (sprot)

A sorbin and SH3 domain-containing protein 2 that is encoded in the genome of human.


TMCC1_HUMAN Transmembrane and coiled-coil domains protein 1 (sprot)

A transmembrane and coiled-coil domains protein 1 that is encoded in the genome of human.


endosome membrane tubulation

A membrane tubulation process occurring in an endosome membrane.


endosome fission

The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.


endoplasmic reticulum-endosome membrane contact site

A contact site between the endoplasmic reticulum membrane and the endosome membrane.


PHF14_HUMAN PHD finger protein 14 (sprot)

A PHD finger protein 14 that is encoded in the genome of human.


germinal center B cell differentiation

The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).


mesenchymal cell proliferation involved in lung development

The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


negative regulation of mesenchymal cell proliferation

Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


negative regulation of platelet-derived growth factor receptor-alpha signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway.


SASH1_HUMAN SAM and SH3 domain-containing protein 1 (sprot)

A SAM and SH3 domain-containing protein 1 that is encoded in the genome of human.


positive regulation of lipopolysaccharide-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.


regulation of protein K63-linked ubiquitination

Any process that modulates the frequency, rate or extent of protein K63-linked ubiquitination.


regulation of protein autoubiquitination

Any process that modulates the frequency, rate or extent of protein autoubiquitination.


regulation of epithelial cell migration

Any process that modulates the frequency, rate or extent of epithelial cell migration.


CSCL1_HUMAN CSC1-like protein 1 (sprot)

A CSC1-like protein 1 that is encoded in the genome of human.


osmolarity-sensing monoatomic cation channel activity

Enables the transmembrane transfer of a monoatomic cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides.


FARP2_HUMAN FERM, ARHGEF and pleckstrin domain-containing protein 2 (sprot)

A FERM, ARHGEF and pleckstrin domain-containing protein 2 that is encoded in the genome of human.


hair cycle process

A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.


regulation of integrin activation

Any process that modulates the frequency, rate, or extent of integrin activation.


UBXN7_HUMAN UBX domain-containing protein 7 (sprot)

A UBX domain-containing protein 7 that is encoded in the genome of human.


VCP-NPL4-UFD1 AAA ATPase complex

A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).


KLH18_HUMAN Kelch-like protein 18 (sprot)

A kelch-like protein 18 that is encoded in the genome of human.


positive regulation of mitotic cell cycle phase transition

Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition.


ZN432_HUMAN Zinc finger protein 432 (sprot)

A zinc finger protein 432 that is encoded in the genome of human.


LRIG2_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 2 (sprot)

A leucine-rich repeats and immunoglobulin-like domains protein 2 that is encoded in the genome of human.


regulation of platelet-derived growth factor receptor signaling pathway

Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.


negative regulation of axon regeneration

Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.


negative regulation of membrane protein ectodomain proteolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.


innervation

The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue.


TOX_HUMAN Thymocyte selection-associated high mobility group box protein TOX (sprot)

A thymocyte selection-associated high mobility group box protein TOX that is encoded in the genome of human.


CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment

The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.


NK T cell lineage commitment

The process in which a pro-T cell becomes committed to becoming an NK T cell.


positive regulation of natural killer cell differentiation

Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation.


CD4-positive, alpha-beta T cell lineage commitment

The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell.


CD8-positive, alpha-beta T cell lineage commitment

The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell.


positive regulation of DNA demethylation

Any process that activates or increases the frequency, rate or extent of DNA demethylation.


SUN1_HUMAN SUN domain-containing protein 1 (sprot)

A SUN domain-containing protein 1 that is encoded in the genome of human.


cytoskeleton-nuclear membrane anchor activity

The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane.


nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration.


meiotic attachment of telomere to nuclear envelope

The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation.


nuclear matrix anchoring at nuclear membrane

The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane.


meiotic nuclear membrane microtubule tethering complex

A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.


PLPHP_HUMAN Pyridoxal phosphate homeostasis protein (sprot)

A pyridoxal phosphate homeostasis protein PLPBP that is encoded in the genome of human.


ERLN2_HUMAN Erlin-2 (sprot)

An erlin-2 that is encoded in the genome of human.


PRP6_HUMAN Pre-mRNA-processing factor 6 (sprot)

A pre-mRNA-processing factor 6 that is encoded in the genome of human.


RNA localization

A process in which RNA is transported to, or maintained in, a specific location.


DKK1_HUMAN Dickkopf-related protein 1 (sprot)

A dickkopf-related protein 1 that is encoded in the genome of human.


receptor antagonist activity

The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.


endoderm formation

The formation of the endoderm during gastrulation.


heart induction

The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart.


endocardial cushion development

The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


negative regulation of mesodermal cell fate specification

Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.


regulation of endodermal cell fate specification

Any process that mediates the specification of a cell into an endoderm cell.


positive regulation of Wnt signaling pathway, calcium modulating pathway

Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).


regulation of synaptic transmission, glutamatergic

Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.


Wnt signaling pathway involved in somitogenesis

The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis.


synapse pruning

A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.


regulation of dopaminergic neuron differentiation

Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation.


negative regulation of Wnt-Frizzled-LRP5/6 complex assembly

Any process that stops, prevents or reduces the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly.


positive regulation of midbrain dopaminergic neuron differentiation

Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation.


negative regulation of presynapse assembly

Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly.


positive regulation of Wnt signaling pathway, planar cell polarity pathway

Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway.


AGRL1_HUMAN Adhesion G protein-coupled receptor L1 (sprot)

An adhesion G protein-coupled receptor L1 that is encoded in the genome of human.


latrotoxin receptor activity

Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


ABCA8_HUMAN ABC-type organic anion transporter ABCA8 (sprot)

An ABC-type organic anion transporter ABCA8 that is encoded in the genome of human.


positive regulation of cholesterol efflux

Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.


PCF11_HUMAN Pre-mRNA cleavage complex 2 protein Pcf11 (sprot)

A pre-mRNA cleavage complex 2 protein Pcf11 that is encoded in the genome of human.


termination of RNA polymerase II transcription

A transcription termination process that completes the production of a primary RNA polymerase II transcript.


co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

Any process involved in transcription termination-coupled 3' processing of RNA polymerase II mRNA transcripts by the 3' end cleavage  and addition of a poly(A) tail. This pathway is required for the maturation of primary protein-encoding transcripts into functional mRNAs that can be exported from the nucleus and translated in the cytoplasm, but is also required for polyadenylation-dependent decay.


NFAT5_HUMAN Nuclear factor of activated T-cells 5 (sprot)

A nuclear factor of activated T-cells 5 that is encoded in the genome of human.


R-loop processing

A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability.


regulation of calcineurin-NFAT signaling cascade

Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade.


cellular hyperosmotic response

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.


positive regulation of leukocyte adhesion to vascular endothelial cell

Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell.


ENDD1_HUMAN Endonuclease domain-containing 1 protein (sprot)

An endonuclease domain-containing 1 protein that is encoded in the genome of human.


CDK14_HUMAN Cyclin-dependent kinase 14 (sprot)

A cyclin-dependent kinase 14 that is encoded in the genome of human.


cyclin-dependent protein kinase holoenzyme complex

Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.


cytoplasmic cyclin-dependent protein kinase holoenzyme complex

Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.


GLCE_HUMAN D-glucuronyl C5-epimerase (sprot)

A D-glucuronyl C5-epimerase that is encoded in the genome of human.


Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate.


heparin biosynthetic process

The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (sprot)

A glutaminase kidney isoform, mitochondrial that is encoded in the genome of human.


glutaminase activity

Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.


glutamate biosynthetic process

The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.


glutamine catabolic process

The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.


HAUS5_HUMAN HAUS augmin-like complex subunit 5 (sprot)

A HAUS augmin-like complex subunit 5 that is encoded in the genome of human.


regulation of microtubule nucleation

Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.


HAUS complex

A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex.


mitotic spindle microtubule

Any microtubule that is part of a mitotic spindle; anchored at one spindle pole.


ABLM3_HUMAN Actin-binding LIM protein 3 (sprot)

An actin-binding LIM protein 3 that is encoded in the genome of human.


SLIK3_HUMAN SLIT and NTRK-like protein 3 (sprot)

A SLIT and NTRK-like protein 3 that is encoded in the genome of human.


terminal button organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.


neurotransmitter-gated ion channel clustering

The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane.


gephyrin clustering involved in postsynaptic density assembly

The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses.


RNF37_HUMAN RING finger protein 37 (sprot)

A RING finger protein 37 that is encoded in the genome of human.


ubiquitin-ubiquitin ligase activity

Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.


FBX21_HUMAN F-box only protein 21 (sprot)

An F-box only protein 21 that is encoded in the genome of human.


KDM4B_HUMAN Lysine-specific demethylase 4B (sprot)

A lysine-specific demethylase 4B that is encoded in the genome of human.


RHBT3_HUMAN Rho-related BTB domain-containing protein 3 (sprot)

A Rho-related BTB domain-containing protein 3 that is encoded in the genome of human.


SO2B1_HUMAN Solute carrier organic anion transporter family member 2B1 (sprot)

A solute carrier organic anion transporter family member 2B1 that is encoded in the genome of human.


sodium-independent organic anion transmembrane transporter activity

Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner.


heme catabolic process

The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.


sodium-independent organic anion transport

The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


SOGA1_HUMAN Protein SOGA1 (sprot)

A protein SOGA1 that is encoded in the genome of human.


UBP19_HUMAN Ubiquitin carboxyl-terminal hydrolase 19 (sprot)

A ubiquitin carboxyl-terminal hydrolase 19 that is encoded in the genome of human.


negative regulation of skeletal muscle tissue development

Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.


positive regulation of cell cycle process

Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.


regulation of ERAD pathway

Any process that modulates the frequency, rate or extent of ERAD pathway.


WDR47_HUMAN WD repeat-containing protein 47 (sprot)

A WD repeat-containing protein 47 that is encoded in the genome of human.


cerebral cortex radial glia-guided migration

The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.


corpus callosum development

The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.


motor behavior

The specific neuromuscular movement of a single organism in response to external or internal stimuli.


detection of hot stimulus involved in thermoception

The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception.


TRI37_HUMAN E3 ubiquitin-protein ligase TRIM37 (sprot)

An E3 ubiquitin-protein ligase TRIM37 that is encoded in the genome of human.


histone H2AK119 ubiquitin ligase activity

Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-119 residue.


negative regulation of centriole replication

Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication.


AP2A2_HUMAN AP-2 complex subunit alpha-2 (sprot)

An AP-2 complex subunit alpha-2 that is encoded in the genome of human.


postsynaptic neurotransmitter receptor internalization

A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle.


AP-2 adaptor complex

A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).


SC31A_HUMAN Protein transport protein Sec31A (sprot)

A protein transport protein Sec31A that is encoded in the genome of human.


COPII-coated ER to Golgi transport vesicle

A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).


vesicle coat

A membrane coat found on a coated vesicle.


CMTA2_HUMAN Calmodulin-binding transcription activator 2 (sprot)

A calmodulin-binding transcription activator 2 that is encoded in the genome of human.


CSTN1_HUMAN Calsyntenin-1 (sprot)

A calsyntenin-1 that is encoded in the genome of human.


X11-like protein binding

Binding to X11-like protein, a neuron-specific adaptor protein.


neurotransmitter receptor transport to postsynaptic membrane

The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.


vesicle-mediated transport in synapse

Any vesicle-mediated transport that occurs in a synapse.


postsynaptic endosome

An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse.


CE152_HUMAN Centrosomal protein of 152 kDa (sprot)

A centrosomal protein of 152 kDa that is encoded in the genome of human.


FA13A_HUMAN Protein FAM13A (sprot)

A protein FAM13A that is encoded in the genome of human.


ARHGF_HUMAN Rho guanine nucleotide exchange factor 15 (sprot)

A Rho guanine nucleotide exchange factor 15 that is encoded in the genome of human.


regulation of postsynapse assembly

Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.


negative regulation of synapse maturation

Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation.


SLIK5_HUMAN SLIT and NTRK-like protein 5 (sprot)

A SLIT and NTRK-like protein 5 that is encoded in the genome of human.


striatum development

The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.


circulatory system development

The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.


HEXI1_HUMAN Protein HEXIM1 (sprot)

A protein HEXIM1 that is encoded in the genome of human.


cyclin-dependent protein serine/threonine kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.


snRNA binding

Binding to a small nuclear RNA (snRNA).


positive regulation of signal transduction by p53 class mediator

Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.


7SK snRNP

A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb.


SOX30_HUMAN Transcription factor SOX-30 (sprot)

A transcription factor SOX-30 that is encoded in the genome of human.


response to corticosteroid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.


proacrosomal vesicle fusion

Fusion of the membrane of proacrosomal vesicle with the membrane of another proacrosomal vesicle to form the acrosome.


OR2F2_HUMAN Olfactory receptor 2F2 (sprot)

An olfactory receptor 2F2 that is encoded in the genome of human.


OR6B1_HUMAN Olfactory receptor 6B1 (sprot)

An olfactory receptor 6B1 that is encoded in the genome of human.


O4F21_HUMAN Olfactory receptor 4F21 (sprot)

An olfactory receptor 4F21 that is encoded in the genome of human.


UPP2_HUMAN Uridine phosphorylase 2 (sprot)

A uridine phosphorylase 2 that is encoded in the genome of human.


uridine phosphorylase activity

Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.


deoxyuridine phosphorylase activity

Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate.


uridine catabolic process

The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.


dCMP catabolic process

The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate.


UMP salvage

Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis.


uridine metabolic process

The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.


type III intermediate filament

A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments.


OR2A4_HUMAN Olfactory receptor 2A4 (sprot)

An olfactory receptor 2A4 that is encoded in the genome of human.


ZO3_HUMAN Tight junction protein ZO-3 (sprot)

A tight junction protein ZO-3 that is encoded in the genome of human.


INMT_HUMAN Indolethylamine N-methyltransferase (sprot)

An indolethylamine N-methyltransferase that is encoded in the genome of human.


thioether S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.


amine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.


Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine.


DIRA1_HUMAN GTP-binding protein Di-Ras1 (sprot)

A GTP-binding protein Di-Ras1 that is encoded in the genome of human.


RPP14_HUMAN Ribonuclease P protein subunit p14 (sprot)

A ribonuclease P protein subunit p14 that is encoded in the genome of human.


CCNB2_HUMAN G2/mitotic-specific cyclin-B2 (sprot)

A G2/mitotic-specific cyclin-B2 that is encoded in the genome of human.


KCNK2_HUMAN Potassium channel subfamily K member 2 (sprot)

A potassium channel subfamily K member 2 that is encoded in the genome of human.


outward rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force.


positive regulation of cellular response to hypoxia

Any process that activates or increases the frequency, rate or extent of cellular response to hypoxia.


astrocyte projection

A prolongation or process extending from the soma of an astrocyte and wrapping around neurons.


YIF1A_HUMAN Protein YIF1A (sprot)

A protein YIF1A that is encoded in the genome of human.


UBR5_HUMAN E3 ubiquitin-protein ligase UBR5 (sprot)

An E3 ubiquitin-protein ligase UBR5 that is encoded in the genome of human.


heterochromatin boundary formation

A process that forms a boundary that limits the spreading of heterochromatin along a chromosome.


progesterone receptor signaling pathway

The series of molecular signals initiated by progesterone binding to its receptor in the cytoplasm.


REC8_HUMAN Meiotic recombination protein REC8 homolog (sprot)

A meiotic recombination protein REC8 that is encoded in the genome of human.


seminiferous tubule development

The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa.


FSBP_HUMAN Fibrinogen silencer-binding protein (sprot)

A fibrinogen silencer-binding protein that is encoded in the genome of human.


ALX3_HUMAN Homeobox protein aristaless-like 3 (sprot)

A homeobox protein aristaless-like 3 that is encoded in the genome of human.


embryonic skeletal system morphogenesis

The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.


AGFG2_HUMAN Arf-GAP domain and FG repeat-containing protein 2 (sprot)

An Arf-GAP domain and FG repeat-containing protein 2 that is encoded in the genome of human.


PRS23_HUMAN Serine protease 23 (sprot)

A serine protease 23 that is encoded in the genome of human.


NKX22_HUMAN Homeobox protein Nkx-2.2 (sprot)

A homeobox protein Nkx-2.2 that is encoded in the genome of human.


pancreatic A cell fate commitment

The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.


type B pancreatic cell fate commitment

The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.


pancreatic PP cell fate commitment

The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.


spinal cord motor neuron differentiation

The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


spinal cord oligodendrocyte cell fate specification

The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway.


optic nerve development

The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.


ventral spinal cord interneuron fate determination

The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.


neuroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.


SCAF4_HUMAN SR-related and CTD-associated factor 4 (sprot)

An SR-related and CTD-associated factor 4 that is encoded in the genome of human.


RNA polymerase II C-terminal domain phosphoserine binding

Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II.


negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled

Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled.


ZN202_HUMAN Zinc finger protein 202 (sprot)

A zinc finger protein 202 that is encoded in the genome of human.


S1PR2_HUMAN Sphingosine 1-phosphate receptor 2 (sprot)

A sphingosine 1-phosphate receptor 2 that is encoded in the genome of human.


Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein.


negative regulation of excitatory postsynaptic potential

Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


NDUB6_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (sprot)

An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 that is encoded in the genome of human.


MFN2_HUMAN Mitofusin-2 (sprot)

A mitofusin-2 that is encoded in the genome of human.


protein localization to phagophore assembly site

Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS).


mitochondrial membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.


camera-type eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.


mitochondrion localization

Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.


DUS14_HUMAN Dual specificity protein phosphatase 14 (sprot)

A dual specificity protein phosphatase 14 that is encoded in the genome of human.


MAP kinase tyrosine/serine/threonine phosphatase activity

Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.


SPN1_HUMAN Snurportin-1 (sprot)

A snurportin-1 that is encoded in the genome of human.


RNA import into nucleus

The import of RNA from the cytoplasm to the nucleus.


snRNA import into nucleus

The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus.


TNF15_HUMAN Tumor necrosis factor ligand superfamily member 15 (sprot)

A tumor necrosis factor ligand superfamily member 15 that is encoded in the genome of human.


RIMB1_HUMAN Peripheral-type benzodiazepine receptor-associated protein 1 (sprot)

A peripheral-type benzodiazepine receptor-associated protein 1 that is encoded in the genome of human.


benzodiazepine receptor binding

Binding to a peripheral benzodiazepine receptor (PBR).


ARK73_HUMAN Aflatoxin B1 aldehyde reductase member 3 (sprot)

An aflatoxin B1 aldehyde reductase member 3 that is encoded in the genome of human.


UBE4B_HUMAN Ubiquitin conjugation factor E4 B (sprot)

A ubiquitin conjugation factor E4 B that is encoded in the genome of human.


granzyme-mediated apoptotic signaling pathway

The series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.


NXPH2_HUMAN Neurexophilin-2 (sprot)

A neurexophilin-2 that is encoded in the genome of human.


NXPH3_HUMAN Neurexophilin-3 (sprot)

A neurexophilin-3 that is encoded in the genome of human.


NXPH4_HUMAN Neurexophilin-4 (sprot)

A neurexophilin-4 that is encoded in the genome of human.


ZFPL1_HUMAN Zinc finger protein-like 1 (sprot)

A zinc finger protein-like 1 that is encoded in the genome of human.


ELP1_HUMAN Elongator complex protein 1 (sprot)

An elongator complex protein 1 that is encoded in the genome of human.


tRNA wobble uridine modification

The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.


elongator holoenzyme complex

A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA.


UBL3_HUMAN Ubiquitin-like protein 3 (sprot)

A ubiquitin-like protein 3 that is encoded in the genome of human.


GBRAP_HUMAN Gamma-aminobutyric acid receptor-associated protein (sprot)

A gamma-aminobutyric acid receptor-associated protein that is encoded in the genome of human.


positive regulation of protein K48-linked ubiquitination

Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination.


NDUA3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 that is encoded in the genome of human.


NDUB4_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (sprot)

An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 that is encoded in the genome of human.


NDUB8_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial that is encoded in the genome of human.


CDRT1_HUMAN F-box and WD repeat domain containing protein 10B (sprot)

An F-box and WD repeat domain containing protein 10B that is encoded in the genome of human.


SCEL_HUMAN Sciellin (sprot)

A sciellin that is encoded in the genome of human.


GAAS1_HUMAN Uncharacterized protein GAS8-AS1 (sprot)


NDUB2_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial that is encoded in the genome of human.


CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (sprot)

A voltage-dependent T-type calcium channel subunit alpha-1H that is encoded in the genome of human.


voltage-gated monoatomic ion channel activity

Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


aldosterone biosynthetic process

The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.


cortisol biosynthetic process

The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


cellular response to potassium ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.


NDUA7_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 that is encoded in the genome of human.


VAMP5_HUMAN Vesicle-associated membrane protein 5 (sprot)

A vesicle-associated membrane protein 5 that is encoded in the genome of human.


UNC5C_HUMAN Netrin receptor UNC5C (sprot)

A netrin receptor UNC5C that is encoded in the genome of human.


netrin receptor activity involved in chemorepulsion

Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin.


anterior/posterior axon guidance

The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.


chemorepulsion of axon

The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.


dorsal root ganglion development

The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.


OAZ2_HUMAN Ornithine decarboxylase antizyme 2 (sprot)

An ornithine decarboxylase antizyme 2 that is encoded in the genome of human.


ornithine decarboxylase inhibitor activity

Binds to and stops, prevents or reduces the activity of ornithine decarboxylase.


polyamine metabolic process

The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups.


polyamine biosynthetic process

The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups.


negative regulation of polyamine transmembrane transport

Any process that stops, prevents or reduces the frequency, rate or extent of polyamine transmembrane transport.


CSPG5_HUMAN Chondroitin sulfate proteoglycan 5 (sprot)

A chondroitin sulfate proteoglycan 5 that is encoded in the genome of human.


glial cell projection elongation

The process of creating an elongation or projection from a glial cell.


RTN3_HUMAN Reticulon-3 (sprot)

A reticulon-3 that is encoded in the genome of human.


endoplasmic reticulum tubular network organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section.


endoplasmic reticulum tubular network formation

The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section.


KLHL2_HUMAN Kelch-like protein 2 (sprot)

A kelch-like protein 2 that is encoded in the genome of human.


RCBT2_HUMAN RCC1 and BTB domain-containing protein 2 (sprot)

An RCC1 and BTB domain-containing protein 2 that is encoded in the genome of human.


RHIT_HUMAN Transcriptional repressor RHIT (sprot)

A zinc finger protein 205 that is encoded in the genome of human.


positive regulation of hydrogen peroxide biosynthetic process

Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.


LETM1_HUMAN Mitochondrial proton/calcium exchanger protein (sprot)

A mitochondrial proton/calcium exchanger protein that is encoded in the genome of human.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).


cristae formation

The assembly of cristae, the inwards folds of the inner mitochondrial membrane.


mitochondrial calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.


negative regulation of mitochondrial calcium ion concentration

Any process that decreases the concentration of calcium ions in mitochondria.


calcium export from the mitochondrion

A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol.


mitochondrial potassium ion transmembrane transport

The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion.


regulation of cellular hyperosmotic salinity response

Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.


PCDH8_HUMAN Protocadherin-8 (sprot)

A protocadherin-8 that is encoded in the genome of human.


regulation of synaptic membrane adhesion

Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.


EPN2_HUMAN Epsin-2 (sprot)

An epsin-2 that is encoded in the genome of human.


negative regulation of sprouting angiogenesis

Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis.


STBD1_HUMAN Starch-binding domain-containing protein 1 (sprot)

A starch-binding domain-containing protein 1 that is encoded in the genome of human.


glycogen binding

Binding to glycogen.


starch binding

Binding to starch.


glycogen catabolic process

The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.


glycophagy

The selective autophagy process in which cellular glycogen is delivered to the vacuole and degraded in response to changing cellular conditions.


LERL1_HUMAN Leptin receptor overlapping transcript-like 1 (sprot)

A leptin receptor overlapping transcript-like 1 that is encoded in the genome of human.


ZRAB2_HUMAN Zinc finger Ran-binding domain-containing protein 2 (sprot)

A zinc finger Ran-binding domain-containing protein 2 that is encoded in the genome of human.


SNX4_HUMAN Sorting nexin-4 (sprot)

A sorting nexin-4 that is encoded in the genome of human.


positive regulation of histamine secretion by mast cell

Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell.


presynaptic endosome

An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles.


OR5F1_HUMAN Olfactory receptor 5F1 (sprot)

An olfactory receptor 5F1 that is encoded in the genome of human.


OR6A2_HUMAN Olfactory receptor 6A2 (sprot)

An olfactory receptor 6A2 that is encoded in the genome of human.


ZWINT_HUMAN ZW10 interactor (sprot)

A ZW10 interactor that is encoded in the genome of human.


homologous chromosome orientation in meiotic metaphase I

The cell cycle process in which the sister centromeres and kinetochores of one chromosome are fused and orientated so the chromosomes attach to microtubules that emanate from the same spindle pole. This process ensures that homologous l chromosomes are segregated at anaphase of meiosis I.


regulation of meiosis I spindle assembly checkpoint

Any process that modulates the frequency, rate or extent of the meiosis I spindle assembly checkpoint.


Knl1/Spc105 complex

A kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans and yeast respectively, it consists of KNL1/Spc105p and ZWINT/Kre28p.


VENTX_HUMAN Homeobox protein VENTX (sprot)

A homeobox protein VENTX that is encoded in the genome of human.


LC7L3_HUMAN Luc7-like protein 3 (sprot)

A cisplatin resistance-associated overexpressed protein that is encoded in the genome of human.


KI20A_HUMAN Kinesin-like protein KIF20A (sprot)

A kinesin-like protein KIF20A that is encoded in the genome of human.


APOL3_HUMAN Apolipoprotein L3 (sprot)

An apolipoprotein L3 that is encoded in the genome of human.


LRAT_HUMAN Lecithin retinol acyltransferase (sprot)

A lecithin retinol acyltransferase that is encoded in the genome of human.


O-palmitoyltransferase activity

Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule.


retinol binding

Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation.


Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine.


lecithin:11-cis retinol acyltransferase activity

Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine <=> a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine.


positive regulation of lipid transport

Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


SPDEF_HUMAN SAM pointed domain-containing Ets transcription factor (sprot)

A SAM pointed domain-containing Ets transcription factor that is encoded in the genome of human.


glandular epithelial cell development

The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


negative regulation of cell fate commitment

Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


positive regulation of cell fate commitment

Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


lung goblet cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins.


epithelial cell fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell.


KIF4A_HUMAN Chromosome-associated kinesin KIF4A (sprot)

A chromosome-associated kinesin KIF4A that is encoded in the genome of human.


MBD4_HUMAN Methyl-CpG-binding domain protein 4 (sprot)

A methyl-CpG-binding domain protein 4 that is encoded in the genome of human.


satellite DNA binding

Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA.


pyrimidine-specific mismatch base pair DNA N-glycosylase activity

Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.


DNA N-glycosylase activity

Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.


MTMR5_HUMAN Myotubularin-related protein 5 (sprot)

A myotubularin-related protein 5 that is encoded in the genome of human.


GOSR1_HUMAN Golgi SNAP receptor complex member 1 (sprot)

A Golgi SNAP receptor complex member 1 that is encoded in the genome of human.


KAT7_HUMAN Histone acetyltransferase KAT7 (sprot)

A histone acetyltransferase KAT7 that is encoded in the genome of human.


histone H4K16 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4.


histone H4 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4.


histone H3K14 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14).


histone H3K23 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23).


histone H4K5 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5).


histone H4K8 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8).


histone H3K4 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4).


internal peptidyl-lysine acetylation

The addition of an acetyl group to a non-terminal lysine residue in a protein.


stress-activated protein kinase signaling cascade

The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal.


response to sorbitol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus.


response to hydroxyurea

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.


response to actinomycin D

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus.


response to dithiothreitol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus.


response to anisomycin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus.


DNA replication-dependent chromatin disassembly

The disruption of nucleosomes during DNA replication to allow the replication machinery to access the DNA.


histone H3-K14 acetyltransferase complex

A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3.


MRP6_HUMAN ATP-binding cassette sub-family C member 6 (sprot)

An ATP-binding cassette sub-family C member 6 that is encoded in the genome of human.


inhibition of non-skeletal tissue mineralization

A homeostatic process involved in the maintenance of non-mineral tissue, by preventing mineralization of non-skeletal tissue.


response to sodium phosphate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus.


I18RA_HUMAN Interleukin-18 receptor accessory protein (sprot)

An interleukin-18 receptor accessory protein that is encoded in the genome of human.


interleukin-18 receptor activity

Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


interleukin-18 receptor complex

A protein complex that binds interleukin-18; comprises an alpha and a beta subunit.


GA45G_HUMAN Growth arrest and DNA damage-inducible protein GADD45 gamma (sprot)

A growth arrest and DNA damage-inducible protein GADD45 gamma that is encoded in the genome of human.


UCP5_HUMAN Brain mitochondrial carrier protein 1 (sprot)

A brain mitochondrial carrier protein 1 that is encoded in the genome of human.


solute:inorganic anion antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out).


proton transmembrane transporter activity

Enables the transfer of a proton from one side of a membrane to the other.


KCNH1_HUMAN Potassium voltage-gated channel subfamily H member 1 (sprot)

A voltage-gated potassium channel KCNH1 that is encoded in the genome of human.


cyclic nucleotide binding

Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.


delayed rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.


ATE1_HUMAN Arginyl-tRNA--protein transferase 1 (sprot)

An arginyl-tRNA--protein transferase 1 that is encoded in the genome of human.


Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).


protein arginylation

The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway.


PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (sprot)

A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B that is encoded in the genome of human.


operant conditioning

Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.


negative regulation of steroid hormone biosynthetic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.


5HT3B_HUMAN 5-hydroxytryptamine receptor 3B (sprot)

A 5-hydroxytryptamine receptor 3B that is encoded in the genome of human.


GRP1_HUMAN RAS guanyl-releasing protein 1 (sprot)

A RAS guanyl-releasing protein 1 that is encoded in the genome of human.


positive regulation of granulocyte macrophage colony-stimulating factor production

Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (sprot)

A poly [ADP-ribose] polymerase tankyrase-1 that is encoded in the genome of human.


NAD+ ADP-ribosyltransferase activity

Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.


Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide.


regulation of telomere maintenance via telomerase

Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase.


protein poly-ADP-ribosylation

The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain.


protein auto-ADP-ribosylation

The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.


negative regulation of telomere maintenance via telomere lengthening

Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening.


negative regulation of telomeric DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding.


negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric

Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric.


CCDB1_HUMAN Cyclin-D1-binding protein 1 (sprot)

A cyclin-D1-binding protein 1 that is encoded in the genome of human.


LYPD3_HUMAN Ly6/PLAUR domain-containing protein 3 (sprot)

An Ly6/PLAUR domain-containing protein 3 that is encoded in the genome of human.


KCNK5_HUMAN Potassium channel subfamily K member 5 (sprot)

A potassium channel subfamily K member 5 that is encoded in the genome of human.


potassium ion export across plasma membrane

The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.


VAPB_HUMAN Vesicle-associated membrane protein-associated protein B/C (sprot)

A vesicle-associated membrane protein-associated protein B/C that is encoded in the genome of human.


FFAT motif binding

Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.


COPII-coated vesicle budding

The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.


RASL1_HUMAN RasGAP-activating-like protein 1 (sprot)

A RasGAP-activating-like protein 1 that is encoded in the genome of human.


SNAPN_HUMAN SNARE-associated protein Snapin (sprot)

A SNARE-associated protein Snapin that is encoded in the genome of human.


retrograde axonal transport

The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.


synaptic vesicle maturation

Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.


synaptic vesicle fusion to presynaptic active zone membrane

Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.


regulation of protein binding

Any process that modulates the frequency, rate or extent of protein binding.


regulation of endosome size

Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis.


regulation of lysosome size

Any process that modulates the size of a lysosome.


positive regulation of late endosome to lysosome transport

Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport.