NUD4B_HUMAN Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (sprot)

A protein that is a translation product of the NUDT4B gene in human.


RNA binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to an RNA molecule or a portion thereof.


metal ion binding

Binding to a metal ion.


cytosol

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.


KV37_HUMAN Probable non-functional immunoglobulin kappa variable 3-7 (sprot)

A protein that is a translation product of the IGKV3-7 gene in human.


adaptive immune response

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).


plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.


immunoglobulin complex

A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


KVD42_HUMAN Probable non-functional immunoglobulin kappa variable 1D-42 (sprot)

A protein that is a translation product of the IGKV1D-42 gene in human.


LV469_HUMAN Immunoglobulin lambda variable 4-69 (sprot)

A protein that is a translation product of the IGLV4-69 gene in human.


LV861_HUMAN Immunoglobulin lambda variable 8-61 (sprot)

A protein that is a translation product of the IGLV8-61 gene in human.


LV460_HUMAN Immunoglobulin lambda variable 4-60 (sprot)

A protein that is a translation product of the IGLV4-60 gene in human.


LVK55_HUMAN Probable non-functional immunoglobulin lambda variable 11-55 (sprot)

A protein that is a translation product of the IGLV11-55 gene in human.


LVX54_HUMAN Immunoglobulin lambda variable 10-54 (sprot)

A protein that is a translation product of the IGLV10-54 gene in human.


LV150_HUMAN Probable non-functional immunoglobulin lambda variable 1-50 (sprot)

A protein that is a translation product of the IGLV1-50 gene in human.


LV548_HUMAN Probable non-functional immunoglobulin lambda variable 5-48 (sprot)

A protein that is a translation product of the IGLV5-48 gene in human.


LV746_HUMAN Immunoglobulin lambda variable 7-46 (sprot)

A protein that is a translation product of the IGLV7-46 gene in human.


LV537_HUMAN Immunoglobulin lambda variable 5-37 (sprot)

A protein that is a translation product of the IGLV5-37 gene in human.


LV233_HUMAN Probable non-functional immunoglobulin lambda variable 2-33 (sprot)

A protein that is a translation product of the IGLV2-33 gene in human.


LV322_HUMAN Immunoglobulin lambda variable 3-22 (sprot)

A protein that is a translation product of the IGLV3-22 gene in human.


LV218_HUMAN Immunoglobulin lambda variable 2-18 (sprot)

A protein that is a translation product of the IGLV2-18 gene in human.


LV316_HUMAN Immunoglobulin lambda variable 3-16 (sprot)

A protein that is a translation product of the IGLV3-16 gene in human.


LV312_HUMAN Immunoglobulin lambda variable 3-12 (sprot)

A protein that is a translation product of the IGLV3-12 gene in human.


LV310_HUMAN Immunoglobulin lambda variable 3-10 (sprot)

A protein that is a translation product of the IGLV3-10 gene in human.


LV39_HUMAN Immunoglobulin lambda variable 3-9 (sprot)

A protein that is a translation product of the IGLV3-9 gene in human.


LV403_HUMAN Immunoglobulin lambda variable 4-3 (sprot)

A protein that is a translation product of the IGLV4-3 gene in human.


TVG11_HUMAN Probable non-functional T cell receptor gamma variable 11 (sprot)

A protein that is a translation product of the TRGV11 gene in human.


T cell receptor complex

A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.


TVB73_HUMAN Probable non-functional T cell receptor beta variable 7-3 (sprot)

A protein that is a translation product of the TRBV7-3 gene in human.


TVB19_HUMAN T cell receptor beta variable 19 (sprot)

A protein that is a translation product of the TRBV19 gene in human.


alpha-beta T cell receptor complex

A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein.


TVBT1_HUMAN T cell receptor beta variable 20-1 (sprot)

A protein that is a translation product of the TRBV20-1 gene in human.


TVBX1_HUMAN T cell receptor beta variable 24-1 (sprot)

A protein that is a translation product of the TRBV24-1 gene in human.


TVBY1_HUMAN T cell receptor beta variable 25-1 (sprot)

A protein that is a translation product of the TRBV25-1 gene in human.


KV228_HUMAN Immunoglobulin kappa variable 2-28 (sprot)

A protein that is a translation product of the IGKV2-28 gene in human.


extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.


HV364_HUMAN Immunoglobulin heavy variable 3-64 (sprot)

A protein that is a translation product of the IGHV3-64 gene in human.


TRGV2_HUMAN T cell receptor gamma variable 2 (sprot)

A protein that is a translation product of the TRGV2 gene in human.


innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.


HV404_HUMAN Immunoglobulin heavy variable 4-4 (sprot)

A protein that is a translation product of the IGHV4-4 gene in human.


KVD24_HUMAN Probable non-functional immunoglobulin kappa variable 2D-24 (sprot)

A protein that is a translation product of the IGKV2D-24 gene in human.


TRGJ1_HUMAN T cell receptor gamma joining 1 (sprot)

A protein that is a translation product of the TRGJ1 gene in human.


KVD29_HUMAN Immunoglobulin kappa variable 2D-29 (sprot)

A protein that is a translation product of the IGKV2D-29 gene in human.


KVD17_HUMAN Immunoglobulin kappa variable 1D-17 (sprot)

A protein that is a translation product of the IGKV1D-17 gene in human.


KV127_HUMAN Immunoglobulin kappa variable 1-27 (sprot)

A protein that is a translation product of the IGKV1-27 gene in human.


KVD30_HUMAN Immunoglobulin kappa variable 2D-30 (sprot)

A protein that is a translation product of the IGKV2D-30 gene in human.


KV137_HUMAN Probable non-functional immunoglobulinn kappa variable 1-37 (sprot)

A protein that is a translation product of the IGKV1-37 gene in human.


TVAL2_HUMAN T cell receptor alpha variable 12-2 (sprot)

A protein that is a translation product of the TRAV12-2 gene in human.


TVA6_HUMAN T cell receptor alpha variable 6 (sprot)

A protein that is a translation product of the TRAV6 gene in human.


TVA91_HUMAN T cell receptor alpha variable 9-1 (sprot)

A protein that is a translation product of the TRAV9-1 gene in human.


TVA7_HUMAN T cell receptor alpha variable 7 (sprot)

A protein that is a translation product of the TRAV7 gene in human.


TVA36_HUMAN T cell receptor alpha variable 36/delta variable 7 (sprot)

A protein that is a translation product of the TRAV36DV7 gene in human.


TVA23_HUMAN T cell receptor alpha variable 23/delta variable 6 (sprot)

A protein that is a translation product of the TRAV23DV6 gene in human.


TVA18_HUMAN T cell receptor alpha variable 18 (sprot)

A protein that is a translation product of the TRAV18 gene in human.


TJA3_HUMAN T cell receptor alpha joining 3 (sprot)

A protein that is a translation product of the TRAJ3 gene in human.


TJA42_HUMAN T cell receptor alpha joining 42 (sprot)

A protein that is a translation product of the TRAJ42 gene in human.


TJA31_HUMAN T cell receptor alpha joining 31 (sprot)

A protein that is a translation product of the TRAJ31 gene in human.


TRDJ1_HUMAN T cell receptor delta joining 1 (sprot)

A protein that is a translation product of the TRDJ1 gene in human.


AQP7B_HUMAN Aquaporin-7B (sprot)

A protein that is a translation product of the AQP7B gene in human.


urea transmembrane transport

The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


LV545_HUMAN Immunoglobulin lambda variable 5-45 (sprot)

A protein that is a translation product of the IGLV5-45 gene in human.


HV432_HUMAN Immunoglobulin heavy variable 4-30-2 (sprot)

A protein that is a translation product of the IGHV4-30-2 gene in human.


KVD15_HUMAN Immunoglobulin kappa variable 3D-15 (sprot)

A protein that is a translation product of the IGKV3D-15 gene in human.


KVD08_HUMAN Immunoglobulin kappa variable 1D-8 (sprot)

A protein that is a translation product of the IGKV1D-8 gene in human.


TVA30_HUMAN T cell receptor alpha variable 30 (sprot)

A protein that is a translation product of the TRAV30 gene in human.


TVA27_HUMAN T cell receptor alpha variable 27 (sprot)

A protein that is a translation product of the TRAV27 gene in human.


protein binding

Binding to a protein.


immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.


defense response to Gram-positive bacterium

Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.


TVA92_HUMAN T cell receptor alpha variable 9-2 (sprot)

A protein that is a translation product of the TRAV9-2 gene in human.


TVAZ1_HUMAN T cell receptor alpha variable 26-1 (sprot)

A protein that is a translation product of the TRAV26-1 gene in human.


TM265_HUMAN Transmembrane protein 265 (sprot)

A protein that is a translation product of the TMEM265 gene in human.


membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.


NBPFJ_HUMAN Neuroblastoma breakpoint family member 19 (sprot)


cytoplasm

The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.


ZN892_HUMAN Zinc finger protein 892 (sprot)


TVB16_HUMAN T cell receptor beta variable 16 (sprot)

A protein that is a translation product of the TRBV16 gene in human.


TBC3D_HUMAN TBC1 domain family member 3D (sprot)

A protein that is a translation product of the TBC1D3D gene in human.


KV240_HUMAN Immunoglobulin kappa variable 2-40 (sprot)

A protein that is a translation product of the IGKV2-40 gene in human.


MEIKN_HUMAN Meiosis-specific kinetochore protein (sprot)

A meiosis-specific kinetochore protein that is encoded in the genome of human.


male meiosis chromosome segregation

The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male.


meiotic sister chromatid cohesion involved in meiosis I

The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I.


female meiosis chromosome segregation

The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.


homologous chromosome segregation

The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets.


meiotic sister chromatid cohesion, centromeric

The cell cycle process in which centromeres of sister chromatids are joined during meiosis.


kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.


condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.


TBC3I_HUMAN TBC1 domain family member 3I (sprot)

A protein that is a translation product of the TBC1D3I gene in human.


A0A087WZK3_HUMAN KRAB domain-containing protein (Fragment) (trembl)


regulation of DNA-templated transcription

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.


TVB17_HUMAN Probable non-functional T cell receptor beta variable 17 (sprot)

A protein that is a translation product of the TRBV17 gene in human.


TVB18_HUMAN T cell receptor beta variable 18 (sprot)

A protein that is a translation product of the TRBV18 gene in human.


TBC3E_HUMAN TBC1 domain family member 3E (sprot)

A protein that is a translation product of the TBC1D3E gene in human.


A0A087X1C1_HUMAN Thymosin beta 15B (trembl)


actin filament organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.


cytoskeleton

A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.


CP2D7_HUMAN Putative cytochrome P450 2D7 (sprot)


aromatase activity

Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.


xenobiotic metabolic process

The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


xenobiotic catabolic process

The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


iron ion binding

Binding to an iron (Fe) ion.


mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.


TBC3K_HUMAN TBC1 domain family member 3K (sprot)

A protein that is a translation product of the TBC1D3K gene in human.


D131B_HUMAN Beta-defensin 131B (sprot)

A protein that is a translation product of the DEFB131B gene in human.


defense response to bacterium

Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.


NT2NR_HUMAN Notch homolog 2 N-terminal-like protein R (sprot)


calcium ion binding

Binding to a calcium ion (Ca2+).


SIM26_HUMAN Small integral membrane protein 26 (sprot)

A protein that is a translation product of the SMIM26 gene in human.


CC187_HUMAN Coiled-coil domain-containing protein 187 (sprot)

A coiled-coil domain-containing protein 187 that is encoded in the genome of human.


microtubule binding

Binding to a microtubule, a filament composed of tubulin monomers.


microtubule anchoring

Any process in which a microtubule is maintained in a specific location in a cell.


centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.


ORN4C_HUMAN Olfactory receptor 4N4C (sprot)

A protein that is a translation product of the OR4N4C gene in human.


G protein-coupled receptor activity

Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


G protein-coupled receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.


detection of chemical stimulus involved in sensory perception of smell

The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal.


KVD26_HUMAN Immunoglobulin kappa variable 2D-26 (sprot)

A protein that is a translation product of the IGKV2D-26 gene in human.


KVD11_HUMAN Immunoglobulin kappa variable 3D-11 (sprot)

A protein that is a translation product of the IGKV3D-11 gene in human.


LV552_HUMAN Immunoglobulin lambda variable 5-52 (sprot)

A protein that is a translation product of the IGLV5-52 gene in human.


LV332_HUMAN Probable non-functional immunoglobulin lambda variable 3-32 (sprot)

A protein that is a translation product of the IGLV3-32 gene in human.


TVG10_HUMAN Probable non-functional T cell receptor gamma variable 10 (sprot)

A protein that is a translation product of the TRGV10 gene in human.


TRGV1_HUMAN Probable non-functional T cell receptor gamma variable (sprot)

A protein that is a translation product of the TRGV1 gene in human.


TVB53_HUMAN Probable non-functional T cell receptor beta variable 5-3 (sprot)

A protein that is a translation product of the TRBV5-3 gene in human.


TVB67_HUMAN Probable non-functional T cell receptor beta variable 6-7 (sprot)

A protein that is a translation product of the TRBV6-7 gene in human.


TVB57_HUMAN Probable non-functional T cell receptor beta variable 5-7 (sprot)

A protein that is a translation product of the TRBV5-7 gene in human.


TVB23_HUMAN Probable non-functional T cell receptor beta variable 23-1 (sprot)

A protein that is a translation product of the TRBV23-1 gene in human.


HV145_HUMAN Immunoglobulin heavy variable 1-45 (sprot)

A protein that is a translation product of the IGHV1-45 gene in human.


HV349_HUMAN Immunoglobulin heavy variable 3-49 (sprot)

A protein that is a translation product of the IGHV3-49 gene in human.


KVD21_HUMAN Immunoglobulin kappa variable 6D-21 (sprot)

A protein that is a translation product of the IGKV6D-21 gene in human.


TJB26_HUMAN T cell receptor beta joining 2-6 (sprot)

A protein that is a translation product of the TRBJ2-6 gene in human.


LJ01_HUMAN Immunoglobulin lambda joining 1 (sprot)

A protein that is a translation product of the IGLJ1 gene in human.


TJB27_HUMAN T cell receptor beta joining 2-7 (sprot)

A protein that is a translation product of the TRBJ2-7 gene in human.


TJB24_HUMAN T cell receptor beta joining 2-4 (sprot)

A protein that is a translation product of the TRBJ2-4 gene in human.


KJ01_HUMAN Immunoglobulin kappa joining 1 (sprot)

A protein that is a translation product of the IGKJ1 gene in human.


TJB22_HUMAN T cell receptor beta joining 2-2 (sprot)

A protein that is a translation product of the TRBJ2-2 gene in human.


TJB25_HUMAN T cell receptor beta joining 2-5 (sprot)

A protein that is a translation product of the TRBJ2-5 gene in human.


TJB21_HUMAN T cell receptor beta joining 2-1 (sprot)

A protein that is a translation product of the TRBJ2-1 gene in human.


TVA14_HUMAN T cell receptor alpha variable 14/delta variable 4 (sprot)

A protein that is a translation product of the TRAV14DV4 gene in human.


TVB13_HUMAN T cell receptor beta variable 13 (sprot)

A protein that is a translation product of the TRBV13 gene in human.


TVB66_HUMAN T cell receptor beta variable 6-6 (sprot)

A protein that is a translation product of the TRBV6-6 gene in human.


TVB68_HUMAN T cell receptor beta variable 6-8 (sprot)

A protein that is a translation product of the TRBV6-8 gene in human.


TVA83_HUMAN T cell receptor alpha variable 8-3 (sprot)

A protein that is a translation product of the TRAV8-3 gene in human.


TVA81_HUMAN T cell receptor alpha variable 8-1 (sprot)

A protein that is a translation product of the TRAV8-1 gene in human.


TVB71_HUMAN Probable non-functional T cell receptor beta variable 7-1 (sprot)

A protein that is a translation product of the TRBV7-1 gene in human.


TVA16_HUMAN T cell receptor alpha variable 16 (sprot)

A protein that is a translation product of the TRAV16 gene in human.


TVA19_HUMAN T cell receptor alpha variable 19 (sprot)

A protein that is a translation product of the TRAV19 gene in human.


MHC protein binding

Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


peptide antigen binding

Binding to an antigen peptide.


A0A0B4J1T7_HUMAN Lymphocyte antigen 6 family member G6E (trembl)


transmembrane receptor protein serine/threonine kinase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


transmembrane receptor protein serine/threonine kinase signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.


synapse

The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.


LV136_HUMAN Immunoglobulin lambda variable 1-36 (sprot)

A protein that is a translation product of the IGLV1-36 gene in human.


TRGV5_HUMAN T cell receptor gamma variable 5 (sprot)

A protein that is a translation product of the TRGV5 gene in human.


TVB9_HUMAN T cell receptor beta variable 9 (sprot)

A protein that is a translation product of the TRBV9 gene in human.


HV601_HUMAN Immunoglobulin heavy variable 6-1 (sprot)

A protein that is a translation product of the IGHV6-1 gene in human.


HV315_HUMAN Immunoglobulin heavy variable 3-15 (sprot)

A protein that is a translation product of the IGHV3-15 gene in human.


HV321_HUMAN Immunoglobulin heavy variable 3-21 (sprot)

A protein that is a translation product of the IGHV3-21 gene in human.


HV226_HUMAN Immunoglobulin heavy variable 2-26 (sprot)

A protein that is a translation product of the IGHV2-26 gene in human.


HV373_HUMAN Immunoglobulin heavy variable 3-73 (sprot)

A protein that is a translation product of the IGHV3-73 gene in human.


HV781_HUMAN Probable non-functional immunoglobulin heavy variable 7-81 (sprot)

A protein that is a translation product of the IGHV7-81 gene in human.


HV374_HUMAN Immunoglobulin heavy variable 3-74 (sprot)

A protein that is a translation product of the IGHV3-74 gene in human.


HV343_HUMAN Immunoglobulin heavy variable 3-43 (sprot)

A protein that is a translation product of the IGHV3-43 gene in human.


LV949_HUMAN Immunoglobulin lambda variable 9-49 (sprot)

A protein that is a translation product of the IGLV9-49 gene in human.


HV372_HUMAN Immunoglobulin heavy variable 3-72 (sprot)

A protein that is a translation product of the IGHV3-72 gene in human.


KVD43_HUMAN Immunoglobulin kappa variable 1D-43 (sprot)

A protein that is a translation product of the IGKV1D-43 gene in human.


TJB23_HUMAN T cell receptor beta joining 2-3 (sprot)

A protein that is a translation product of the TRBJ2-3 gene in human.


TVA2_HUMAN T cell receptor alpha variable 2 (sprot)

A protein that is a translation product of the TRAV2 gene in human.


TVAM2_HUMAN T cell receptor alpha variable 13-2 (sprot)

A protein that is a translation product of the TRAV13-2 gene in human.


TVA82_HUMAN T cell receptor alpha variable 8-2 (sprot)

A protein that is a translation product of the TRAV8-2 gene in human.


TVA12_HUMAN T cell receptor alpha variable 1-2 (sprot)

A protein that is a translation product of the TRAV1-2 gene in human.


TVA10_HUMAN T cell receptor alpha variable 10 (sprot)

A protein that is a translation product of the TRAV10 gene in human.


TVAM1_HUMAN T cell receptor alpha variable 13-1 (sprot)

A protein that is a translation product of the TRAV13-1 gene in human.


TVA3_HUMAN T cell receptor alpha variable 3 (sprot)

A protein that is a translation product of the TRAV3 gene in human.


TVAL1_HUMAN T cell receptor alpha variable 12-1 (sprot)

A protein that is a translation product of the TRAV12-1 gene in human.


TVA11_HUMAN T cell receptor alpha variable 1-1 (sprot)

A protein that is a translation product of the TRAV1-1 gene in human.


TVA5_HUMAN T cell receptor alpha variable 5 (sprot)

A protein that is a translation product of the TRAV5 gene in human.


TVA86_HUMAN T cell receptor alpha variable 8-6 (sprot)

A protein that is a translation product of the TRAV8-6 gene in human.


TVA39_HUMAN T cell receptor alpha variable 39 (sprot)

A protein that is a translation product of the TRAV39 gene in human.


TV381_HUMAN T cell receptor alpha variable 38-1 (sprot)

A protein that is a translation product of the TRAV38-1 gene in human.


TVAZ2_HUMAN T cell receptor alpha variable 26-2 (sprot)

A protein that is a translation product of the TRAV26-2 gene in human.


TVA41_HUMAN T cell receptor alpha variable 41 (sprot)

A protein that is a translation product of the TRAV41 gene in human.


TVA4_HUMAN T cell receptor alpha variable 4 (sprot)

A protein that is a translation product of the TRAV4 gene in human.


TVAL3_HUMAN T cell receptor alpha variable 12-3 (sprot)

A protein that is a translation product of the TRAV12-3 gene in human.


TVA24_HUMAN T cell receptor alpha variable 24 (sprot)

A protein that is a translation product of the TRAV24 gene in human.


TVA34_HUMAN T cell receptor alpha variable 34 (sprot)

A protein that is a translation product of the TRAV34 gene in human.


TVA20_HUMAN T cell receptor alpha variable 20 (sprot)

A protein that is a translation product of the TRAV20 gene in human.


TVA17_HUMAN T cell receptor alpha variable 17 (sprot)

A protein that is a translation product of the TRAV17 gene in human.


TVA25_HUMAN T cell receptor alpha variable 25 (sprot)

A protein that is a translation product of the TRAV25 gene in human.


TVA22_HUMAN T cell receptor alpha variable 22 (sprot)

A protein that is a translation product of the TRAV22 gene in human.


TVA21_HUMAN T cell receptor alpha variable 21 (sprot)

A protein that is a translation product of the TRAV21 gene in human.


TVA40_HUMAN T cell receptor alpha variable 40 (sprot)

A protein that is a translation product of the TRAV40 gene in human.


GAL3B_HUMAN Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (sprot)


KVD13_HUMAN Immunoglobulin kappa variable 1D-13 (sprot)

A protein that is a translation product of the IGKV1D-13 gene in human.


TVBL4_HUMAN T cell receptor beta variable 12-4 (sprot)

A protein that is a translation product of the TRBV12-4 gene in human.


PIOS1_HUMAN Protein PIGBOS1 (sprot)

A protein that is a translation product of the PIGBOS1 gene in human.


response to unfolded protein

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.


regulation of endoplasmic reticulum unfolded protein response

Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response.


mitochondrial outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.


SIK1B_HUMAN Putative serine/threonine-protein kinase SIK1B (sprot)


magnesium ion binding

Binding to a magnesium (Mg) ion.


ATP binding

Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.


protein serine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.


phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.


HV69D_HUMAN Immunoglobulin heavy variable 1-69D (sprot)

A protein that is a translation product of the IGHV1-69D gene in human.


KV621_HUMAN Immunoglobulin kappa variable 6-21 (sprot)

A protein that is a translation product of the IGKV6-21 gene in human.


KVD20_HUMAN Immunoglobulin kappa variable 3D-20 (sprot)

A protein that is a translation product of the IGKV3D-20 gene in human.


KVD41_HUMAN Probable non-functional immunoglobulin kappa variable 6D-41 (sprot)

A protein that is a translation product of the IGKV6D-41 gene in human.


TRGV8_HUMAN T cell receptor gamma variable 8 (sprot)

A protein that is a translation product of the TRGV8 gene in human.


TRGV4_HUMAN T cell receptor gamma variable 4 (sprot)

A protein that is a translation product of the TRGV4 gene in human.


HV103_HUMAN Immunoglobulin heavy variable 1-3 (sprot)

A protein that is a translation product of the IGHV1-3 gene in human.


HV316_HUMAN Probable non-functional immunoglobulin heavy variable 3-16 (sprot)

A protein that is a translation product of the IGHV3-16 gene in human.


HV118_HUMAN Immunoglobulin heavy variable 1-18 (sprot)

A protein that is a translation product of the IGHV1-18 gene in human.


HV320_HUMAN Immunoglobulin heavy variable 3-20 (sprot)

A protein that is a translation product of the IGHV3-20 gene in human.


HV124_HUMAN Immunoglobulin heavy variable 1-24 (sprot)

A protein that is a translation product of the IGHV1-24 gene in human.


HV428_HUMAN Immunoglobulin heavy variable 4-28 (sprot)

A protein that is a translation product of the IGHV4-28 gene in human.


HV335_HUMAN Probable non-functional immunoglobulin heavy variable 3-35 (sprot)

A protein that is a translation product of the IGHV3-35 gene in human.


HV338_HUMAN Probable non-functional immunoglobulin heavy variable 3-38 (sprot)

A protein that is a translation product of the IGHV3-38 gene in human.


HV551_HUMAN Immunoglobulin heavy variable 5-51 (sprot)

A protein that is a translation product of the IGHV5-51 gene in human.


HV158_HUMAN Immunoglobulin heavy variable 1-58 (sprot)

A protein that is a translation product of the IGHV1-58 gene in human.


HV461_HUMAN Immunoglobulin heavy variable 4-61 (sprot)

A protein that is a translation product of the IGHV4-61 gene in human.


HV366_HUMAN Immunoglobulin heavy variable 3-66 (sprot)

A protein that is a translation product of the IGHV3-66 gene in human.


HV70D_HUMAN Immunoglobulin heavy variable 2-70D (sprot)

A protein that is a translation product of the IGHV2-70D gene in human.


KVD07_HUMAN Immunoglobulin kappa variable 3D-7 (sprot)

A protein that is a translation product of the IGKV3D-7 gene in human.


TVB54_HUMAN T cell receptor beta variable 5-4 (sprot)

A protein that is a translation product of the TRBV5-4 gene in human.


HJ01_HUMAN Immunoglobulin heavy joining 1 (sprot)

A protein that is a translation product of the IGHJ1 gene in human.


KV108_HUMAN Immunoglobulin kappa variable 1-8 (sprot)

A protein that is a translation product of the IGKV1-8 gene in human.


KV224_HUMAN Immunoglobulin kappa variable 2-24 (sprot)

A protein that is a translation product of the IGKV2-24 gene in human.


KV109_HUMAN Immunoglobulin kappa variable 1-9 (sprot)

A protein that is a translation product of the IGKV1-9 gene in human.


KV106_HUMAN Immunoglobulin kappa variable 1-6 (sprot)

A protein that is a translation product of the IGKV1-6 gene in human.


KV112_HUMAN Immunoglobulin kappa variable 1-12 (sprot)

A protein that is a translation product of the IGKV1-12 gene in human.


MOTSC_HUMAN Mitochondrial-derived peptide MOTS-c (sprot)

A protein that is a translation product of the MT-RNR1 gene in human.


DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).


DNA-binding transcription factor binding

Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.


osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.


regulation of transcription by RNA polymerase II

Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.


activation of protein kinase activity

Any process that initiates the activity of an inactive protein kinase.


osteoblast proliferation

The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.


regulation of carbohydrate utilization

Any process that modulates the frequency, rate or extent of carbohydrate utilization.


skeletal muscle tissue growth

The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size.


positive regulation of protein serine/threonine kinase activity

Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.


purine-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.


negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity.


extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.


nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.


CC163_HUMAN Transmembrane protein CCDC163 (sprot)

A protein that is a translation product of the CCDC163 gene in human.


keratin filament

A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.


PRA33_HUMAN PRAME family member 33 (sprot)

A protein that is a translation product of the PRAMEF33 gene in human.


positive regulation of cell population proliferation

Any process that activates or increases the rate or extent of cell proliferation.


negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.


negative regulation of cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.


negative regulation of DNA-templated transcription

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.


A0A0G2JMH3_HUMAN ADP-ribosylation factor-like protein 17 C-terminal domain-containing protein (trembl)


GTPase activity

Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.


GTP binding

Binding to GTP, guanosine triphosphate.


HV692_HUMAN Immunoglobulin heavy variable 1-69-2 (sprot)

A protein that is a translation product of the IGHV1-69-2 gene in human.


A0A0G2JNH3_HUMAN Olfactory receptor (trembl)


LV539_HUMAN Immunoglobulin lambda variable 5-39 (sprot)

A protein that is a translation product of the IGLV5-39 gene in human.


HV741_HUMAN Immunoglobulin heavy variable 7-4-1 (sprot)

A protein that is a translation product of the IGHV7-4-1 gene in human.


TX13C_HUMAN Putative testis-expressed protein 13C (sprot)


TJB13_HUMAN T cell receptor beta joining 1-3 (sprot)

A protein that is a translation product of the TRBJ1-3 gene in human.


TJB16_HUMAN T cell receptor beta joining 1-6 (sprot)

A protein that is a translation product of the TRBJ1-6 gene in human.


TJB12_HUMAN T cell receptor beta joining 1-2 (sprot)

A protein that is a translation product of the TRBJ1-2 gene in human.


HV64D_HUMAN Immunoglobulin heavy variable 3-64D (sprot)

A protein that is a translation product of the IGHV3-64D gene in human.


TVB69_HUMAN T cell receptor beta variable 6-9 (sprot)

A protein that is a translation product of the TRBV6-9 gene in human.


TJB11_HUMAN T cell receptor beta joining 1-1 (sprot)

A protein that is a translation product of the TRBJ1-1 gene in human.


TJB14_HUMAN T cell receptor beta joining 1-4 (sprot)

A protein that is a translation product of the TRBJ1-4 gene in human.


TJB15_HUMAN T cell receptor beta joining 1-5 (sprot)

A protein that is a translation product of the TRBJ1-5 gene in human.


HV5X1_HUMAN Immunoglobulin heavy variable 5-10-1 (sprot)

A protein that is a translation product of the IGHV5-10-1 gene in human.


TVB62_HUMAN T cell receptor beta variable 6-2 (sprot)

A protein that is a translation product of the TRBV6-2 gene in human.


TX13D_HUMAN Testis-expressed protein 13D (sprot)

A protein that is a translation product of the TEX13D gene in human.


TVBJ1_HUMAN T cell receptor beta variable 10-1 (sprot)

A protein that is a translation product of the TRBV10-1 gene in human.


TVB65_HUMAN T cell receptor beta variable 6-5 (sprot)

A protein that is a translation product of the TRBV6-5 gene in human.


TVB30_HUMAN T cell receptor beta variable 30 (sprot)

A protein that is a translation product of the TRBV30 gene in human.


TVBK1_HUMAN T cell receptor beta variable 11-1 (sprot)

A protein that is a translation product of the TRBV11-1 gene in human.


TVB27_HUMAN T cell receptor beta variable 27 (sprot)

A protein that is a translation product of the TRBV27 gene in human.


TVB61_HUMAN T cell receptor beta variable 6-1 (sprot)

A protein that is a translation product of the TRBV6-1 gene in human.


TVB77_HUMAN T cell receptor beta variable 7-7 (sprot)

A protein that is a translation product of the TRBV7-7 gene in human.


TVBJ3_HUMAN T cell receptor beta variable 10-3 (sprot)

A protein that is a translation product of the TRBV10-3 gene in human.


TVBJ2_HUMAN T cell receptor beta variable 10-2 (sprot)

A protein that is a translation product of the TRBV10-2 gene in human.


CD3CH_HUMAN Protein CD300H (sprot)

A protein that is a translation product of the CD300H gene in human.


protein homodimerization activity

Binding to an identical protein to form a homodimer.


neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


GLYLB_HUMAN Putative glycine N-acyltransferase-like protein 1B (sprot)

A protein that is a translation product of the GLYATL1B gene in human.


glycine N-acyltransferase activity

Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine.


DP2NB_HUMAN DPEP2 neighbor protein (sprot)

A protein that is a translation product of the DPEP2NB gene in human.


KLF18_HUMAN Kruppel-like factor 18 (sprot)

A protein that is a translation product of the KLF18 gene in human.


TM275_HUMAN Transmembrane protein 275 (sprot)

A transmembrane protein 275 that is encoded in the genome of human.


CENL1_HUMAN Centromere protein V-like protein 1 (sprot)

A protein that is a translation product of the CENPVL1 gene in human.


carbon-sulfur lyase activity

Catalysis of the elimination of hydrogen sulfide or substituted H2S.


ZNOS_HUMAN Putative transmembrane protein ZNF593OS (sprot)


NBDY_HUMAN Negative regulator of P-body association (sprot)

A protein that is a translation product of the NBDY gene in human.


nuclear-transcribed mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.


mRNA processing

Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.


negative regulation of cytoplasmic mRNA processing body assembly

Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.


P-body

A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.


CENL3_HUMAN Centromere protein V-like protein 3 (sprot)

A protein that is a translation product of the CENPVL3 gene in human.


MISFA_HUMAN Mitochondrial sheath formation-associated protein (sprot)

A protein that is a translation product of the SPTY2D1OS gene in human.


ORM2B_HUMAN Olfactory receptor 4M2 (sprot)

A protein that is a translation product of the OR4M2B gene in human.


A0A126GWI2_HUMAN Olfactory receptor (trembl)


A0A140TA62_HUMAN IF rod domain-containing protein (trembl)


structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex.


intermediate filament

A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.


A0A140TA64_HUMAN Uncharacterized protein (trembl)


A0A140TA67_HUMAN Keratin-associated protein 9-6 (trembl)


LCE6A_HUMAN Late cornified envelope protein 6A (sprot)

A late cornified envelope protein 6A that is encoded in the genome of human.


keratinization

The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.


TUNAR_HUMAN Protein TUNAR (sprot)

A protein that is a translation product of the TUNAR gene in human.


ATPase binding

Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.


endoplasmic reticulum calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.


positive regulation of insulin secretion involved in cellular response to glucose stimulus

Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.


negative regulation of neuron differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.


neuron projection morphogenesis

The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.


regulation of cytosolic calcium ion concentration

Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.


endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).


endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.


SMI11_HUMAN Sperm microtubule inner protein 11 (sprot)

A protein that is a translation product of the TEX49 gene in human.


motile cilium

A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.


A0A1B0GTG8_HUMAN Uncharacterized protein (trembl)


CS2IP_HUMAN Casein kinase II subunit alpha'-interacting protein (sprot)

A casein kinase II subunit alpha'-interacting protein that is encoded in the genome of human.


ZN475_HUMAN Zinc finger protein 475 (sprot)


TM272_HUMAN Transmembrane protein 272 (sprot)

A protein that is a translation product of the TMEM272 gene in human.


F237A_HUMAN Protein FAM237A (sprot)

A protein that is a translation product of the FAM237A gene in human.


A0A1B0GTQ1_HUMAN Uncharacterized protein (trembl)


MYMX_HUMAN Protein myomixer (sprot)

A protein myomixer that is encoded in the genome of human.


myoblast fusion

A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


myoblast fusion involved in skeletal muscle regeneration

A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


skeletal muscle tissue regeneration

The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.


plasma membrane fusion

The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.


skeletal muscle organ development

The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.


EDD13_HUMAN Epididymal protein 13 (sprot)

An epididymal protein 13 that is encoded in the genome of human.


ZC11B_HUMAN Zinc finger CCCH domain-containing protein 11B (sprot)

A protein that is a translation product of the ZC3H11B gene in human.


CTXD1_HUMAN Cortexin domain-containing 1 protein (sprot)

A cortexin domain-containing 1 protein that is encoded in the genome of human.


CIROP_HUMAN Ciliated left-right organizer metallopeptidase (sprot)

A protein that is a translation product of the CIROP gene in human.


metalloendopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.


cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.


establishment of left/right asymmetry

The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves.


TEX50_HUMAN Testis-expressed protein 50 (sprot)

A protein that is a translation product of the TEX50 gene in human.


SIM28_HUMAN Small integral membrane protein 28 (sprot)

A protein that is a translation product of the SMIM28 gene in human.


SIM32_HUMAN Small integral membrane protein 32 (sprot)

A protein that is a translation product of the SMIM32 gene in human.


TEX51_HUMAN Testis-expressed protein 51 (sprot)

A protein that is a translation product of the TEX51 gene in human.


UB2L5_HUMAN Ubiquitin-conjugating enzyme E2 L5 (sprot)

A protein that is a translation product of the UBE2L5 gene in human.


ligase activity

Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.


TEX48_HUMAN Testis-expressed protein 48 (sprot)

A protein that is a translation product of the TEX48 gene in human.


A0A1B0GUV8_HUMAN Lipocalin/cytosolic fatty-acid binding domain-containing protein (trembl)


small molecule binding

Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule.


SPEM3_HUMAN Uncharacterized protein SPEM3 (sprot)

A protein that is a translation product of the SPEM3 gene in human.


SIM27_HUMAN Small integral membrane protein 27 (sprot)

A protein that is a translation product of the SMIM27 gene in human.


A0A1B0GUZ9_HUMAN Uncharacterized protein (trembl)


GG6L7_HUMAN Golgin subfamily A member 6-like protein 7 (sprot)

A protein that is a translation product of the GOLGA6L7 gene in human.


cis-Golgi network

The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.


RELD1_HUMAN Reelin domain-containing protein 1 (sprot)

A protein that is a translation product of the REELD1 gene in human.


CTXD2_HUMAN Cortexin domain containing 2 (sprot)

A cortexin domain containing 2 that is encoded in the genome of human.


F237B_HUMAN Protein FAM237B (sprot)

A protein that is a translation product of the FAM237B gene in human.


PRS51_HUMAN Serine protease-like protein 51 (sprot)

A protein that is a translation product of the PRSS51 gene in human.


serine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


A0A1B0GVM2_HUMAN TRPM8 channel associated factor 2C (Fragment) (trembl)


cell junction

A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.


CK097_HUMAN Uncharacterized protein C11orf97 (sprot)

An uncharacterized protein C11orf97 that is encoded in the genome of human.


ciliary basal body

A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.


CB092_HUMAN Uncharacterized protein C2orf92 (sprot)

A protein that is a translation product of the C2orf92 gene in human.


SPAR_HUMAN Small regulatory polypeptide of amino acid response (sprot)

A small regulatory polypeptide of amino acid response that is encoded in the genome of human.


lysosomal proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen.


regulation of skeletal muscle tissue regeneration

Any process that modulates the frequency, rate or extent of skeletal muscle.


cellular response to amino acid stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.


negative regulation of TORC1 signaling

Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.


lysosomal membrane

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.


late endosome membrane

The lipid bilayer surrounding a late endosome.


SIM36_HUMAN Small integral membrane protein 36 (sprot)

A small integral membrane protein 36 that is encoded in the genome of human.


SIM35_HUMAN Small integral membrane protein 35 (sprot)

A small integral membrane protein 35 that is encoded in the genome of human.


SIM31_HUMAN Small integral membrane protein 31 (sprot)

A small integral membrane protein 31 that is encoded in the genome of human.


axon

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.


TM269_HUMAN Transmembrane protein 269 (sprot)

A transmembrane protein 269 that is encoded in the genome of human.


SIM39_HUMAN Small integral membrane protein 39 (sprot)

A protein that is a translation product of the SMIM39 gene in human.


SIM33_HUMAN Small integral membrane protein 33 (sprot)

A small integral membrane protein 33 that is encoded in the genome of human.


SRTM2_HUMAN Serine-rich and transmembrane domain-containing 2 (sprot)

A serine-rich and transmembrane domain-containing 2 that is encoded in the genome of human.


HSFX3_HUMAN Heat shock transcription factor, X-linked member 3 (sprot)

A protein that is a translation product of the HSFX3 gene in human.


DNA-binding transcription factor activity, RNA polymerase II-specific

A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.


chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.


LSP1N_HUMAN LASP1 neighbor protein (sprot)


PVLEF_HUMAN Parvalbumin-like EF-hand-containing protein (sprot)

A protein that is a translation product of the PVALEF gene in human.


TVB76_HUMAN T cell receptor beta variable 7-6 (sprot)

A protein that is a translation product of the TRBV7-6 gene in human.


TVB64_HUMAN T cell receptor beta variable 6-4 (sprot)

A protein that is a translation product of the TRBV6-4 gene in human.


TVB78_HUMAN T cell receptor beta variable 7-8 (sprot)

A protein that is a translation product of the TRBV7-8 gene in human.


TRDV1_HUMAN T cell receptor delta variable 1 (sprot)

A protein that is a translation product of the TRDV1 gene in human.


TVB2_HUMAN T cell receptor beta variable 2 (sprot)

A protein that is a translation product of the TRBV2 gene in human.


TVBL5_HUMAN T cell receptor beta variable 12-5 (sprot)

A protein that is a translation product of the TRBV12-5 gene in human.


TVB74_HUMAN T cell receptor beta variable 7-4 (sprot)

A protein that is a translation product of the TRBV7-4 gene in human.


TVB72_HUMAN T cell receptor beta variable 7-2 (sprot)

A protein that is a translation product of the TRBV7-2 gene in human.


TFKL5_HUMAN TATA-box-binding protein-associated factor 11-like protein 5 (sprot)

A protein that is a translation product of the TAF11L5 gene in human.


protein heterodimerization activity

Binding to a nonidentical protein to form a heterodimer.


positive regulation of DNA-templated transcription

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.


KDM4F_HUMAN Probable lysine-specific demethylase 4F (sprot)


oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.


TFKL4_HUMAN TATA-box-binding protein-associated factor 11-like protein 4 (sprot)

A protein that is a translation product of the TAF11L4 gene in human.


TFLM_HUMAN TATA-box-binding protein-associated factor 11-like protein 13 (sprot)

A protein that is a translation product of the TAF11L13 gene in human.


TFKLN_HUMAN TATA-box-binding protein-associated factor 11-like protein 14 (sprot)

A protein that is a translation product of the TAF11L14 gene in human.


TFKLL_HUMAN TATA-box-binding protein-associated factor 11-like protein 12 (sprot)

A protein that is a translation product of the TAF11L12 gene in human.


TFKLK_HUMAN TATA-box-binding protein-associated factor 11-like protein 11 (sprot)

A protein that is a translation product of the TAF11L11 gene in human.


S72L1_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 1 (sprot)


myosin phosphatase activity

Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.


S72L5_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 5 (sprot)


ERFL_HUMAN ETS domain-containing transcription factor ERF-like (sprot)

A protein that is a translation product of the ERFL gene in human.


sequence-specific DNA binding

Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.


S72L4_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 4 (sprot)


S72L2_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 2 (sprot)


S72L3_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 3 (sprot)


ZN722_HUMAN Zinc finger protein 722 (sprot)

A protein that is a translation product of the ZNF722 gene in human.


KANTR_HUMAN KANTR integral membrane protein (sprot)


GSTT4_HUMAN Glutathione S-transferase theta-4 (sprot)

A glutathione S-transferase theta-4 that is encoded in the genome of human.


TLE7_HUMAN Transducin-like enhancer protein 7 (sprot)

A protein that is a translation product of the TLE7 gene in human.


TFKL9_HUMAN TATA-box-binding protein-associated factor 11-like protein 9 (sprot)

A protein that is a translation product of the TAF11L9 gene in human.


S72L6_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 6 (sprot)


PERC1_HUMAN Protein PERCC1 (sprot)

A protein PERCC1 that is encoded in the genome of human.


enteroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.


digestive tract morphogenesis

The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.


IGB1C_HUMAN Immunoglobulin-binding protein 1 family member C (sprot)


regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.


A0A1W2PRG0_HUMAN glutathione transferase (trembl)


A0A1W2PRN1_HUMAN Golgin subfamily A conserved domain-containing protein (trembl)


Golgi apparatus

A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.


FOXL3_HUMAN Forkhead box protein L3 (sprot)

A protein that is a translation product of the FOXL3 gene in human.


TFKL3_HUMAN TATA-box-binding protein-associated factor 11-like protein 3 (sprot)

A protein that is a translation product of the TAF11L3 gene in human.


A0A286YEU6_HUMAN Olfactory receptor family 1 subfamily R member 1 pseudogene (trembl)


SCGR4_HUMAN Small cysteine and glycine repeat-containing protein 4 (sprot)

A protein that is a translation product of the SCYGR4 gene in human.


SCGRX_HUMAN Small cysteine and glycine repeat-containing protein 10 (sprot)

A protein that is a translation product of the SCYGR10 gene in human.


SCGR1_HUMAN Small cysteine and glycine repeat-containing protein 1 (sprot)

A protein that is a translation product of the SCYGR1 gene in human.


SCGR7_HUMAN Small cysteine and glycine repeat-containing protein 7 (sprot)

A protein that is a translation product of the SCYGR7 gene in human.


SMI44_HUMAN Small integral membrane protein 44 (sprot)

A protein that is a translation product of the SMIM44 gene in human.


A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.


A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.


SCGR5_HUMAN Small cysteine and glycine repeat-containing protein 5 (sprot)

A protein that is a translation product of the SCYGR5 gene in human.


TM271_HUMAN Transmembrane protein 271 (sprot)

A protein that is a translation product of the TMEM271 gene in human.


SCGR3_HUMAN Small cysteine and glycine repeat-containing protein 3 (sprot)

A protein that is a translation product of the SCYGR3 gene in human.


SCGR6_HUMAN Small cysteine and glycine repeat-containing protein 6 (sprot)

A protein that is a translation product of the SCYGR6 gene in human.


SCGR2_HUMAN Small cysteine and glycine repeat-containing protein 2 (sprot)

A protein that is a translation product of the SCYGR2 gene in human.


SCGR8_HUMAN Small cysteine and glycine repeat-containing protein 8 (sprot)

A protein that is a translation product of the SCYGR8 gene in human.


SIM38_HUMAN Small integral membrane protein 38 (sprot)

A protein that is a translation product of the SMIM38 gene in human.


CHO90_HUMAN Uncharacterized protein C8orf90 (sprot)

A protein that is a translation product of the C8orf90 gene in human.


A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome).


A0A2R8Y4L6_HUMAN Olfactory receptor (trembl)


A0A2R8Y4M2_HUMAN Uncharacterized protein (trembl)


A0A2R8Y4M4_HUMAN RING-type domain-containing protein (trembl)


OSP4B_HUMAN Oocyte-secreted protein 4B (sprot)

A protein that is a translation product of the OOSP4B gene in human.


H2BK1_HUMAN Histone H2B type 2-K1 (sprot)

A protein that is a translation product of the H2BK1 gene in human.


structural constituent of chromatin

The action of a molecule that contributes to the structural integrity of chromatin.


nucleosome

A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.


SIM41_HUMAN Small integral membrane protein 41 (sprot)

A protein that is a translation product of the SMIM41 gene in human.


A0A2R8YED5_HUMAN Olfactory receptor (trembl)


A0A2R8YEG4_HUMAN Olfactory receptor (trembl)


A0A2R8YEH3_HUMAN Olfactory receptor (trembl)


A0A2R8YEV3_HUMAN Olfactory receptor (trembl)


OSP4A_HUMAN Oocyte-secreted protein 4A (sprot)

A protein that is a translation product of the OOSP4A gene in human.


OOSP3_HUMAN Oocyte-secreted protein 3 (sprot)

An oocyte-secreted protein 3 that is encoded in the genome of human.


A0A2R8YFR7_HUMAN DH domain-containing protein (trembl)


guanyl-nucleotide exchange factor activity

Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.


intracellular signal transduction

The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.


A0A2R9YJI8_HUMAN Uncharacterized protein (trembl)


monooxygenase activity

Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.


heme binding

Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.


A0A2U3TZM8_HUMAN Uncharacterized protein (trembl)


FXO3B_HUMAN Forkhead box protein O3B (sprot)

A protein that is a translation product of the FOXO3B gene in human.


MCTS2_HUMAN Malignant T-cell-amplified sequence 2 (sprot)

A malignant T cell-amplified sequence 2 that is encoded in the genome of human.


PLGRF_HUMAN POLG alternative reading frame (sprot)

A protein that is a translation product of the POLGARF gene in human.


nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.


TR51G_HUMAN Putative tripartite motif-containing protein 51G (sprot)


zinc ion binding

Binding to a zinc ion (Zn).


A0A3B3IT45_HUMAN Olfactory receptor (trembl)


RMACL_HUMAN RNA guanine-N7 methyltransferase-activating subunit-like protein (sprot)


RNA 5'-cap (guanine-N7)-methylation

The process whereby a guanine in 5-cap is methylated at the N7 position of guanine.


H2AL3_HUMAN Histone H2A-like 3 (sprot)

A protein that is a translation product of the H2AL3 gene in human.


PNT87_HUMAN Transcriptional regulator PINT87aa (sprot)

A protein that is a translation product of the LINC-PINT gene in human.


negative regulation of transcription by RNA polymerase II

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.


T217B_HUMAN Putative transmembrane protein 217B (sprot)


A0A494C0I6_HUMAN Uncharacterized protein (trembl)


A0A494C1I1_HUMAN Uncharacterized protein (trembl)


TSPY9_HUMAN Testis-specific Y-encoded protein 9 (sprot)

A protein that is a translation product of the TSPY9 gene in human.


nucleosome assembly

The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.


spermatogenesis

The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.


gonadal mesoderm development

The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.


cell differentiation

The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


A0A499FJF3_HUMAN Rho-GAP domain-containing protein (trembl)


signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.


TVB42_HUMAN T cell receptor beta variable 4-2 (sprot)

A protein that is a translation product of the TRBV4-2 gene in human.


TVB31_HUMAN T cell receptor beta variable 3-1 (sprot)

A protein that is a translation product of the TRBV3-1 gene in human.


TVB41_HUMAN T cell receptor beta variable 4-1 (sprot)

A protein that is a translation product of the TRBV4-1 gene in human.


TVB51_HUMAN T cell receptor beta variable 5-1 (sprot)

A protein that is a translation product of the TRBV5-1 gene in human.


TVBK2_HUMAN T cell receptor beta variable 11-2 (sprot)

A protein that is a translation product of the TRBV11-2 gene in human.


TVB43_HUMAN T cell receptor beta variable 4-3 (sprot)

A protein that is a translation product of the TRBV4-3 gene in human.


A0A590UK10_HUMAN Rho guanine nucleotide exchange factor 18 (Fragment) (trembl)


small GTPase mediated signal transduction

The series of molecular signals in which a small monomeric GTPase relays a signal.


SMI45_HUMAN Small integral membrane protein 45 (sprot)

A protein that is a translation product of the SMIM45 gene in human.


neuron maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.


TVB55_HUMAN T cell receptor beta variable 5-5 (sprot)

A protein that is a translation product of the TRBV5-5 gene in human.


TVB56_HUMAN T cell receptor beta variable 5-6 (sprot)

A protein that is a translation product of the TRBV5-6 gene in human.


TVB58_HUMAN T cell receptor beta variable 5-8 (sprot)

A protein that is a translation product of the TRBV5-8 gene in human.


TVBK3_HUMAN T cell receptor beta variable 11-3 (sprot)

A protein that is a translation product of the TRBV11-3 gene in human.


TVB14_HUMAN T cell receptor beta variable 14 (sprot)

A protein that is a translation product of the TRBV14 gene in human.


TVB28_HUMAN T cell receptor beta variable 28 (sprot)

A protein that is a translation product of the TRBV28 gene in human.


TVB29_HUMAN T cell receptor beta variable 29-1 (sprot)

A protein that is a translation product of the TRBV29-1 gene in human.


TRBC2_HUMAN T cell receptor beta constant 2 (sprot)

A T cell receptor beta constant 2 that is encoded in the genome of human.


alpha-beta T cell activation

The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


T cell receptor signaling pathway

The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.


SIM42_HUMAN Small integral membrane protein 42 (sprot)

A protein that is a translation product of the SMIM42 gene in human.


NFILZ_HUMAN NFIL3 like protein (sprot)

A protein that is a translation product of the NFILZ gene in human.


DNA-binding transcription factor activity

A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.


TUG1_HUMAN Taurine up-regulated 1 protein (sprot)

A protein that is a translation product of the TUG1 gene in human.


nuclear membrane

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.


mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.


A0A7I2V2S6_HUMAN Uncharacterized protein (trembl)


A0A7I2V3R4_HUMAN RING-type domain-containing protein (trembl)


A0A7P0TAN4_HUMAN Uncharacterized protein (trembl)


positive regulation of transcription by RNA polymerase II

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.


HAPR2_HUMAN HUWE1-associated protein modifying stress responses 2 (sprot)


ubiquitin protein ligase binding

Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.


protein stabilization

Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.


GBG5B_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B (sprot)

A protein that is a translation product of the GNG5B gene in human.


G-protein beta-subunit binding

Binding to a G-protein beta subunit.


heterotrimeric G-protein complex

Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.


RPSA2_HUMAN Small ribosomal subunit protein uS2B (sprot)


structural constituent of ribosome

The action of a molecule that contributes to the structural integrity of the ribosome.


laminin receptor activity

Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity.


laminin binding

Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells.


ribosomal small subunit assembly

The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.


translation

The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.


cytosolic small ribosomal subunit

The small subunit of a ribosome located in the cytosol.


A0A8I5KW96_HUMAN Adenylate kinase 4, mitochondrial (trembl)


adenylate kinase activity

Catalysis of the reaction: ATP + AMP = 2 ADP.


nucleoside triphosphate adenylate kinase activity

Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP.


ADP biosynthetic process

The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate.


AMP metabolic process

The chemical reactions and pathways involving AMP, adenosine monophosphate.


ATP metabolic process

The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.


GTP metabolic process

The chemical reactions and pathways involving GTP, guanosine triphosphate.


The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside.


mitochondrial matrix

The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.


A0A8Q3SIG1_HUMAN Vitellogenin domain-containing protein (trembl)


lipid transporter activity

Enables the directed movement of lipids into, out of or within a cell, or between cells.


lipid transport

The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.


A0A8Q3SIZ7_HUMAN Uncharacterized protein (trembl)


S12A8_HUMAN Solute carrier family 12 member 8 (sprot)

A solute carrier family 12 member 8 that is encoded in the genome of human.


RBM47_HUMAN RNA-binding protein 47 (sprot)

An RNA-binding protein 47 that is encoded in the genome of human.


mRNA 3'-UTR binding

Binding to a 3' untranslated region of an mRNA molecule.


enzyme binding

Binding to an enzyme, a protein with catalytic activity.


enzyme-substrate adaptor activity

An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity.


regulation of alternative mRNA splicing, via spliceosome

Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.


hematopoietic progenitor cell differentiation

The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.


RNA splicing

The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.


cytidine to uridine editing

The conversion of a cytosine residue to uridine in an RNA molecule by deamination.


positive regulation of interleukin-10 production

Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.


positive regulation of type I interferon-mediated signaling pathway

Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway.


3'-UTR-mediated mRNA stabilization

An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.


apolipoprotein B mRNA editing enzyme complex

Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP).


IFT56_HUMAN Intraflagellar transport protein 56 (sprot)

An intraflagellar transport protein 56 that is encoded in the genome of human.


smoothened signaling pathway

The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.


protein transport

The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


axoneme assembly

The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.


intraciliary anterograde transport

The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins.


intraciliary transport

The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.


cilium assembly

The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.


protein localization to cilium

A process in which a protein is transported to, or maintained in, a location within a cilium.


manchette assembly

The aggregation, arrangement and bonding together of a set of components to form a manchette.


cilium

A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.


intraciliary transport particle B

The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa.


neuron projection

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.


ciliary tip

Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction.


FR1L5_HUMAN Fer-1-like protein 5 (sprot)

A Fer-1-like protein 5 that is encoded in the genome of human.


TM129_HUMAN E3 ubiquitin-protein ligase TM129 (sprot)

An E3 ubiquitin-protein ligase TM129 that is encoded in the genome of human.


ubiquitin protein ligase activity

Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.


protein polyubiquitination

Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.


protein ubiquitination

The process in which one or more ubiquitin groups are added to a protein.


ubiquitin-dependent ERAD pathway

The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.


retrograde protein transport, ER to cytosol

The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.


E2F8_HUMAN Transcription factor E2F8 (sprot)

A transcription factor E2F8 that is encoded in the genome of human.


RNA polymerase II cis-regulatory region sequence-specific DNA binding

Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.


cis-regulatory region sequence-specific DNA binding

Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter.


DNA-binding transcription repressor activity

A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.


DNA-binding transcription repressor activity, RNA polymerase II-specific

A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.


identical protein binding

Binding to an identical protein or proteins.


sequence-specific double-stranded DNA binding

Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.


placenta development

The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.


sprouting angiogenesis

The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.


negative regulation of cytokinesis

Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.


positive regulation of DNA endoreduplication

Any process that activates or increases the frequency, rate or extent of DNA endoreduplication.


cell cycle comprising mitosis without cytokinesis

A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N).


fibroblast proliferation

The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.


trophoblast giant cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua.


chorionic trophoblast cell differentiation

The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.


hepatocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.


nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.


UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 (sprot)

A ubiquitin-like modifier-activating enzyme 6 that is encoded in the genome of human.


ubiquitin activating enzyme activity

Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.


FAT10 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond.


ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.


learning

Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.


locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.


amygdala development

The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure.


hippocampus development

The progression of the hippocampus over time from its initial formation until its mature state.


dendritic spine development

The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


ESYT2_HUMAN Extended synaptotagmin-2 (sprot)

An extended synaptotagmin-2 that is encoded in the genome of human.


calcium-dependent phospholipid binding

Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.


phosphatidylethanolamine binding

Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.


phosphatidylcholine binding

Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline.


phosphatidylinositol binding

Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.


cadherin binding

Binding to cadherin, a type I membrane protein involved in cell adhesion.


endocytosis

A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.


endoplasmic reticulum-plasma membrane tethering

The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers.


cytoplasmic side of plasma membrane

The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.


organelle membrane contact site

A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.


endoplasmic reticulum-plasma membrane contact site

A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes.


ESYT3_HUMAN Extended synaptotagmin-3 (sprot)

An extended synaptotagmin-3 that is encoded in the genome of human.


TV382_HUMAN T cell receptor alpha variable 38-2/delta variable 8 (sprot)

A protein that is a translation product of the TRAV38-2DV8 gene in human.


TRDV2_HUMAN T cell receptor delta variable 2 (sprot)

A protein that is a translation product of the TRDV2 gene in human.


TRDV3_HUMAN T cell receptor delta variable 3 (sprot)

A protein that is a translation product of the TRDV3 gene in human.


MED19_HUMAN Mediator of RNA polymerase II transcription subunit 19 (sprot)

A mediator of RNA polymerase II transcription subunit 19 that is encoded in the genome of human.


transcription coregulator activity

A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.


positive regulation of transcription elongation by RNA polymerase II

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


RNA polymerase II preinitiation complex assembly

The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.


positive regulation of transcription initiation by RNA polymerase II

Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.


core mediator complex

A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


BLT3B_HUMAN Bridge-like lipid transfer protein family member 3B (sprot)

A bridge-like lipid transfer protein family member 3B that is encoded in the genome of human.


GARP complex binding

Binding to a GARP complex.


lipid transfer activity

Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids.


early endosome to Golgi transport

The directed movement of substances from early endosomes to the Golgi.