ADP-ribosylarginine hydrolase activity

Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose.


SLUR1_HUMAN Secreted Ly-6/uPAR-related protein 1 (sprot)

A secreted Ly-6/uPAR-related protein 1 that is encoded in the genome of human.


acetylcholine receptor activator activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.


MFAP2_HUMAN Microfibrillar-associated protein 2 (sprot)

A microfibrillar-associated protein 2 that is encoded in the genome of human.


AIF1_HUMAN Allograft inflammatory factor 1 (sprot)

An allograft inflammatory factor 1 that is encoded in the genome of human.


parallel actin filament bundle assembly

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity.


IF5_HUMAN Eukaryotic translation initiation factor 5 (sprot)

A eukaryotic translation initiation factor 5 that is encoded in the genome of human.


S12A2_HUMAN Solute carrier family 12 member 2 (sprot)

A solute carrier family 12 member 2 that is encoded in the genome of human.


positive regulation of aspartate secretion

Any process that activates or increases the frequency, rate or extent of aspartate secretion.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).


chloride:monoatomic cation symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in).


metal ion transmembrane transporter activity

Enables the transfer of metal ions from one side of a membrane to the other.


positive regulation of cell volume

Any process that increases cell volume.


transepithelial ammonium transport

The directed movement of ammonium ions from one side of an epithelium to the other.


inorganic cation import across plasma membrane

The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol.


S12A3_HUMAN Solute carrier family 12 member 3 (sprot)

A solute carrier family 12 member 3 that is encoded in the genome of human.


PSMD4_HUMAN 26S proteasome non-ATPase regulatory subunit 4 (sprot)

A 26S proteasome non-ATPase regulatory subunit 4 that is encoded in the genome of human.


DRG2_HUMAN Developmentally-regulated GTP-binding protein 2 (sprot)

A developmentally-regulated GTP-binding protein 2 that is encoded in the genome of human.


GEM_HUMAN GTP-binding protein GEM (sprot)

A GTP-binding protein GEM that is encoded in the genome of human.


RAD_HUMAN GTP-binding protein RAD (sprot)

A GTP-binding protein RAD that is encoded in the genome of human.


NR1H2_HUMAN Oxysterols receptor LXR-beta (sprot)

An oxysterols receptor LXR-beta that is encoded in the genome of human.


negative regulation of pinocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.


positive regulation of secretion of lysosomal enzymes

Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.


APOC4_HUMAN Apolipoprotein C-IV (sprot)

An apolipoprotein C-IV that is encoded in the genome of human.


PLTP_HUMAN Phospholipid transfer protein (sprot)

A phospholipid transfer protein that is encoded in the genome of human.


very-low-density lipoprotein particle binding

Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.


phospholipid transfer activity

Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


diacylglyceride transfer activity

Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location.


phosphatidylglycerol transfer activity

Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location.


cerebroside transfer activity

Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location.


Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


vitamin E biosynthetic process

The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


glycolipid transport

The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


XPO2_HUMAN Exportin-2 (sprot)

An exportin-2 that is encoded in the genome of human.


BI1_HUMAN Bax inhibitor 1 (sprot)

A Bax inhibitor 1 that is encoded in the genome of human.


endoribonuclease inhibitor activity

Binds to and stops, prevents or reduces the activity of endoribonuclease.


neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.


negative regulation of endoribonuclease activity

Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.


AQP5_HUMAN Aquaporin-5 (sprot)

An aquaporin-5 that is encoded in the genome of human.


TERA_HUMAN Transitional endoplasmic reticulum ATPase (sprot)

A transitional endoplasmic reticulum ATPase that is encoded in the genome of human.


K48-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.


flavin adenine dinucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.


protein-DNA covalent cross-linking repair

The removal of covalent cross-link between DNA and a protein.


positive regulation of protein K63-linked deubiquitination

Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination.


positive regulation of Lys63-specific deubiquitinase activity

Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity.


cellular response to arsenite ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus.


regulation of protein localization to chromatin

Any process that modulates the frequency, rate or extent of protein localization to chromatin.


VCP-NSFL1C complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.


Derlin-1 retrotranslocation complex

A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.


IOD3_HUMAN Thyroxine 5-deiodinase (sprot)

A thyroxine 5-deiodinase that is encoded in the genome of human.


thyroxine 5'-deiodinase activity

Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2.


thyroxine 5-deiodinase activity

Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.


thyroid hormone catabolic process

The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.


brown fat cell proliferation

The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species.


FGF8_HUMAN Fibroblast growth factor 8 (sprot)

A fibroblast growth factor 8 that is encoded in the genome of human.


neural plate morphogenesis

The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.


pallium development

The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon.


subpallium development

The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon.


midbrain-hindbrain boundary development

The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.


MFAP1_HUMAN Microfibrillar-associated protein 1 (sprot)

A microfibrillar-associated protein 1 that is encoded in the genome of human.


MFAP3_HUMAN Microfibril-associated glycoprotein 3 (sprot)

A microfibril-associated glycoprotein 3 that is encoded in the genome of human.


MFAP4_HUMAN Microfibril-associated glycoprotein 4 (sprot)

A microfibril-associated glycoprotein 4 that is encoded in the genome of human.


regulation of collagen metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


ECHB_HUMAN Trifunctional enzyme subunit beta, mitochondrial (sprot)

A trifunctional enzyme subunit beta, mitochondrial that is encoded in the genome of human.


PAR2_HUMAN Proteinase-activated receptor 2 (sprot)

A proteinase-activated receptor 2 that is encoded in the genome of human.


positive regulation of eosinophil degranulation

Any process that activates or increases the frequency, rate or extent of eosinophil degranulation.


leukocyte proliferation

The expansion of a leukocyte population by cell division.


positive regulation of neutrophil mediated killing of gram-negative bacterium

Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil.


potassium channel activating, G protein-coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel.


positive regulation of renin secretion into blood stream

Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream.


regulation of chemokine (C-X-C motif) ligand 2 production

Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production.


AQP4_HUMAN Aquaporin-4 (sprot)

An aquaporin-4 that is encoded in the genome of human.


UCN1_HUMAN Urocortin (sprot)

A urocortin that is encoded in the genome of human.


INHBC_HUMAN Inhibin beta C chain (sprot)

An activin/inhibin beta C chain that is encoded in the genome of human.


GDF10_HUMAN Growth/differentiation factor 10 (sprot)

A bone morphogenetic protein 3B that is encoded in the genome of human.


MANF_HUMAN Mesencephalic astrocyte-derived neurotrophic factor (sprot)

A protein ARMET that is encoded in the genome of human.


vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure

The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system.


MTP_HUMAN Microsomal triglyceride transfer protein large subunit (sprot)

A microsomal triglyceride transfer protein large subunit that is encoded in the genome of human.


triglyceride transfer activity

Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location.


ceramide 1-phosphate transfer activity

Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


plasma lipoprotein particle assembly

The non-covalent aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle.


NCKPL_HUMAN Nck-associated protein 1-like (sprot)

A Nck-associated protein 1-like that is encoded in the genome of human.


TORC2 complex binding

Binding to a TORC2 complex.


positive regulation of CD8-positive, alpha-beta T cell differentiation

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation.


positive regulation of TORC2 signaling

Any process that activates or increases the frequency, rate or extent of TORC2 signaling.


SCAR complex

A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.


AFAD_HUMAN Afadin (sprot)

An afadin that is encoded in the genome of human.


AF10_HUMAN Protein AF-10 (sprot)

A protein AF-10 that is encoded in the genome of human.


AF17_HUMAN Protein AF-17 (sprot)

A protein AF-17 that is encoded in the genome of human.


renal potassium excretion

The elimination of potassium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.


ELL_HUMAN RNA polymerase II elongation factor ELL (sprot)

An RNA polymerase II elongation factor ELL that is encoded in the genome of human.


histone locus body

A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body.


BRPF1_HUMAN Peregrin (sprot)

A peregrin that is encoded in the genome of human.


NP1L1_HUMAN Nucleosome assembly protein 1-like 1 (sprot)

A nucleosome assembly protein 1-like 1 that is encoded in the genome of human.


histone chaperone activity

Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone).


CASP7_HUMAN Caspase-7 (sprot)

A caspase-7 that is encoded in the genome of human.


lymphocyte apoptotic process

Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.


CASP9_HUMAN Caspase-9 (sprot)

A caspase-9 that is encoded in the genome of human.


caspase complex

A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes.


CASP6_HUMAN Caspase-6 (sprot)

A caspase-6 that is encoded in the genome of human.


GP2_HUMAN Pancreatic secretory granule membrane major glycoprotein GP2 (sprot)

A pancreatic secretory granule membrane major glycoprotein GP2 that is encoded in the genome of human.


antigen transcytosis by M cells in mucosal-associated lymphoid tissue

The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT.


ADK_HUMAN Adenosine kinase (sprot)

An adenosine kinase that is encoded in the genome of human.


dATP biosynthetic process

The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate).


DSRAD_HUMAN Double-stranded RNA-specific adenosine deaminase (sprot)

A double-stranded RNA-specific adenosine deaminase that is encoded in the genome of human.


base conversion or substitution editing

Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s).


double-stranded RNA adenosine deaminase activity

Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.


somatic diversification of immune receptors via somatic mutation

The process in which immune receptor genes are diversified through somatic mutation.


adenosine to inosine editing

The conversion of an adenosine residue to inosine in an RNA molecule by deamination.


negative regulation of post-transcriptional gene silencing by regulatory ncRNA

Any process that stops, prevents or reduces the frequency, rate or extent of post-transcriptional gene silencing by RNA.


LAMB2_HUMAN Laminin subunit beta-2 (sprot)

A laminin subunit beta-2 that is encoded in the genome of human.


structural constituent of synapse-associated extracellular matrix

The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.


axon extension involved in regeneration

Long distance growth of a single axon process involved in regeneration of the neuron.


metanephric podocyte development

The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.


metanephric glomerular basement membrane development

The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration.


CDN2D_HUMAN Cyclin-dependent kinase 4 inhibitor D (sprot)

A cyclin-dependent kinase 4 inhibitor D that is encoded in the genome of human.


CADH4_HUMAN Cadherin-4 (sprot)

A cadherin-4 that is encoded in the genome of human.


CADH6_HUMAN Cadherin-6 (sprot)

A cadherin-6 that is encoded in the genome of human.


CADH8_HUMAN Cadherin-8 (sprot)

A cadherin-8 that is encoded in the genome of human.


CAD11_HUMAN Cadherin-11 (sprot)

A cadherin-11 that is encoded in the genome of human.


aortic valve formation

The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.


CAD12_HUMAN Cadherin-12 (sprot)

A cadherin-12 that is encoded in the genome of human.


CAD13_HUMAN Cadherin-13 (sprot)

A cadherin-13 that is encoded in the genome of human.


adiponectin binding

Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism.


localization within membrane

Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.


CAD15_HUMAN Cadherin-15 (sprot)

A cadherin-15 that is encoded in the genome of human.


FOXG1_HUMAN Forkhead box protein G1 (sprot)

A forkhead box protein G1 that is encoded in the genome of human.


pyramidal neuron migration to cerebral cortex

The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex.


FOXA1_HUMAN Hepatocyte nuclear factor 3-alpha (sprot)

A hepatocyte nuclear factor 3-alpha that is encoded in the genome of human.


epithelial cell maturation involved in prostate gland development

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.


respiratory basal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell.


positive regulation of dopaminergic neuron differentiation

Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation.


FOXA3_HUMAN Hepatocyte nuclear factor 3-gamma (sprot)

A hepatocyte nuclear factor 3-gamma that is encoded in the genome of human.


TPD52_HUMAN Tumor protein D52 (sprot)

A tumor protein D52 that is encoded in the genome of human.


LMIP_HUMAN Lens fiber membrane intrinsic protein (sprot)

A lens fiber membrane intrinsic protein that is encoded in the genome of human.


ANM2_HUMAN Protein arginine N-methyltransferase 2 (sprot)

A protein arginine N-methyltransferase 2 that is encoded in the genome of human.


nuclear progesterone receptor binding

Binding to a nuclear progesterone receptor.


histone H3R8 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3.


PKNX1_HUMAN Homeobox protein PKNOX1 (sprot)

A homeobox protein PKNOX1 that is encoded in the genome of human.


SEC13_HUMAN Protein SEC13 homolog (sprot)

A protein SEC13 that is encoded in the genome of human.


NH2L1_HUMAN NHP2-like protein 1 (sprot)

An NHP2-like protein 1 that is encoded in the genome of human.


U4 snRNA binding

Binding to a U4 small nuclear RNA (U4 snRNA).


U4atac snRNA binding

Binding to a U4atac small nuclear RNA (U4atac snRNA).


box C/D RNA binding

Binding to a box C/D small nucleolar RNA.


box C/D snoRNP assembly

The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.


dense fibrillar component

A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.


U4atac snRNP

A ribonucleoprotein complex that contains small nuclear RNA U4atac, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4atac snRNP, most of which remain associated with the U4atac snRNA both while the U4atac snRNP is free or assembled into the U4atac/U6atac complex or into a series of spliceosomal complexes.


PAX9_HUMAN Paired box protein Pax-9 (sprot)

A paired box protein Pax-9 that is encoded in the genome of human.


CCL23_HUMAN C-C motif chemokine 23 (sprot)

A C-C motif chemokine 23 that is encoded in the genome of human.


CCL18_HUMAN C-C motif chemokine 18 (sprot)

A C-C motif chemokine 18 that is encoded in the genome of human.


PSA_HUMAN Puromycin-sensitive aminopeptidase (sprot)

A puromycin-sensitive aminopeptidase that is encoded in the genome of human.


ALR_HUMAN FAD-linked sulfhydryl oxidase ALR (sprot)

An FAD-linked sulfhydryl oxidase ALR that is encoded in the genome of human.


HNRH2_HUMAN Heterogeneous nuclear ribonucleoprotein H2 (sprot)

A heterogeneous nuclear ribonucleoprotein H2 that is encoded in the genome of human.


XG_HUMAN Glycoprotein Xg (sprot)

A glycoprotein Xg that is encoded in the genome of human.


SCOT1_HUMAN Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (sprot)

A succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial that is encoded in the genome of human.


Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA.


ketone catabolic process

The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.


cellular ketone body metabolic process

The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.


SH3BG_HUMAN SH3 domain-binding glutamic acid-rich protein (sprot)

An SH3 domain-binding glutamic acid-rich protein that is encoded in the genome of human.


UCP2_HUMAN Dicarboxylate carrier SLC25A8 (sprot)

A mitochondrial uncoupling protein 2 that is encoded in the genome of human.


oxaloacetate transmembrane transporter activity

Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other.


malate transmembrane transporter activity

Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.


phosphate ion uniporter activity

Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


C4-dicarboxylate transport

The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.


malate transmembrane transport

A process in which a malate ion is transported across a membrane.


The directed movement of oxaloacetate(2-) across a membrane.


SUMO3_HUMAN Small ubiquitin-related modifier 3 (sprot)

A small ubiquitin-related modifier 3 that is encoded in the genome of human.


EIF3B_HUMAN Eukaryotic translation initiation factor 3 subunit B (sprot)

A eukaryotic translation initiation factor 3 subunit B that is encoded in the genome of human.


RAG2_HUMAN V(D)J recombination-activating protein 2 (sprot)

A V(D)J recombination-activating protein 2 that is encoded in the genome of human.


B cell homeostatic proliferation

The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus.


FCGRN_HUMAN IgG receptor FcRn large subunit p51 (sprot)

An IgG receptor FcRn large subunit p51 that is encoded in the genome of human.


IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor

The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.


UCP3_HUMAN Putative mitochondrial transporter UCP3 (sprot)

A mitochondrial uncoupling protein 3 that is encoded in the genome of human.


BID_HUMAN BH3-interacting domain death agonist (sprot)

A BH3-interacting domain death agonist that is encoded in the genome of human.


ATPK_HUMAN ATP synthase subunit f, mitochondrial (sprot)

An ATP synthase subunit f, mitochondrial that is encoded in the genome of human.


GFRA1_HUMAN GDNF family receptor alpha-1 (sprot)

A GDNF family receptor alpha-1 that is encoded in the genome of human.


neurotrophin receptor activity

Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity.


glial cell-derived neurotrophic factor receptor activity

Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


neurotrophin signaling pathway

The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.


DLX1_HUMAN Homeobox protein DLX-1 (sprot)

A homeobox protein DLX-1 that is encoded in the genome of human.


cerebral cortex GABAergic interneuron fate commitment

The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex.


positive regulation of amacrine cell differentiation

Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation.


DLX5_HUMAN Homeobox protein DLX-5 (sprot)

A homeobox protein DLX-5 that is encoded in the genome of human.


interneuron axon guidance

The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions.


DLX6_HUMAN Homeobox protein DLX-6 (sprot)

A homeobox protein DLX-6 that is encoded in the genome of human.


TPTE_HUMAN Putative tyrosine-protein phosphatase TPTE (sprot)

A putative tyrosine-protein phosphatase TPTE that is encoded in the genome of human.


NDUV3_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial that is encoded in the genome of human.


RRP1_HUMAN Ribosomal RNA processing protein 1 homolog A (sprot)

A ribosomal RNA processing protein 1 homolog A that is encoded in the genome of human.


SYMC_HUMAN Methionine--tRNA ligase, cytoplasmic (sprot)

A methionine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


methionine-tRNA ligase activity

Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).


methionyl-tRNA aminoacylation

The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


ITA1_HUMAN Integrin alpha-1 (sprot)

An integrin alpha-1 that is encoded in the genome of human.


CATW_HUMAN Cathepsin W (sprot)

A cathepsin W that is encoded in the genome of human.


ARP19_HUMAN cAMP-regulated phosphoprotein 19 (sprot)

A cAMP-regulated phosphoprotein 19 that is encoded in the genome of human.


MAZ_HUMAN Myc-associated zinc finger protein (sprot)

A Myc-associated zinc finger protein that is encoded in the genome of human.


CMC4_HUMAN Cx9C motif-containing protein 4 (sprot)

A Cx9C motif-containing protein 4 that is encoded in the genome of human.


MTCP1_HUMAN Protein p13 MTCP-1 (sprot)

A protein p13 MTCP-1 that is encoded in the genome of human.


TCL1A_HUMAN T-cell leukemia/lymphoma protein 1A (sprot)

A T-cell leukemia/lymphoma protein 1A that is encoded in the genome of human.


DPOE2_HUMAN DNA polymerase epsilon subunit 2 (sprot)

A DNA polymerase epsilon subunit 2 that is encoded in the genome of human.


epsilon DNA polymerase complex

A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.


P2RX3_HUMAN P2X purinoceptor 3 (sprot)

A P2X purinoceptor 3 that is encoded in the genome of human.


AP1S2_HUMAN AP-1 complex subunit sigma-2 (sprot)

An AP-1 complex subunit sigma-2 that is encoded in the genome of human.


ATP68_HUMAN ATP synthase subunit ATP5MJ, mitochondrial (sprot)

An ATP synthase subunit ATP5MJ, mitochondrial that is encoded in the genome of human.


ATP5E_HUMAN ATP synthase subunit epsilon, mitochondrial (sprot)

An ATP synthase subunit epsilon, mitochondrial that is encoded in the genome of human.


ATP5I_HUMAN ATP synthase subunit e, mitochondrial (sprot)

An ATP synthase subunit e, mitochondrial that is encoded in the genome of human.


LEG4_HUMAN Galectin-4 (sprot)

A galectin-4 that is encoded in the genome of human.


antibacterial peptide biosynthetic process

The chemical reactions and pathways resulting in the formation of an antibacterial peptide.


HDAC4_HUMAN Histone deacetylase 4 (sprot)

A histone deacetylase 4 that is encoded in the genome of human.


peptidyl-lysine deacetylation

The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.


IF6_HUMAN Eukaryotic translation initiation factor 6 (sprot)

A eukaryotic translation initiation factor 6 that is encoded in the genome of human.


CAV3_HUMAN Caveolin-3 (sprot)

A caveolin-3 that is encoded in the genome of human.


regulation of signal transduction by receptor internalization

Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway.


regulation of nerve growth factor receptor activity

Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor.


negative regulation of sarcomere organization

Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


cellular response to organonitrogen compound

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.


regulation of membrane depolarization during cardiac muscle cell action potential

Any process that modulates the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential.


negative regulation of membrane depolarization during cardiac muscle cell action potential

Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential.


regulation of calcium ion transmembrane transporter activity

Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity.


positive regulation of caveolin-mediated endocytosis

Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis.


CTBP2_HUMAN C-terminal-binding protein 2 (sprot)

A C-terminal-binding protein 2 that is encoded in the genome of human.


structural constituent of presynaptic active zone

The action of a molecule that contributes to the structural integrity of a presynaptic active zone.


maintenance of presynaptic active zone structure

A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters.


DSCR4_HUMAN Down syndrome critical region protein 4 (sprot)

A Down syndrome critical region protein 4 that is encoded in the genome of human.


NDUA6_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 that is encoded in the genome of human.


TM50B_HUMAN Transmembrane protein 50B (sprot)

A transmembrane protein 50B that is encoded in the genome of human.


ARL4C_HUMAN ADP-ribosylation factor-like protein 4C (sprot)

An ADP-ribosylation factor-like protein 4C that is encoded in the genome of human.


PEX3_HUMAN Peroxisomal biogenesis factor 3 (sprot)

A peroxisomal biogenesis factor 3 that is encoded in the genome of human.


NDK5_HUMAN Nucleoside diphosphate kinase homolog 5 (sprot)

A nucleoside diphosphate kinase homolog 5 that is encoded in the genome of human.


radial spoke

Protein complex that links the outer microtubule doublet of a 9+2 type ciliary or flagellar axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.


PER3_HUMAN Period circadian protein homolog 3 (sprot)

A period circadian protein homolog 3 that is encoded in the genome of human.


SOX10_HUMAN Transcription factor SOX-10 (sprot)

A transcription factor SOX-10 that is encoded in the genome of human.


positive regulation of gliogenesis

Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.


KCNQ4_HUMAN Potassium voltage-gated channel subfamily KQT member 4 (sprot)

A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human.


WNT3_HUMAN Proto-oncogene Wnt-3 (sprot)

A proto-oncogene Wnt-3 that is encoded in the genome of human.


positive regulation of collateral sprouting in absence of injury

Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury.


Spemann organizer formation at the anterior end of the primitive streak

Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan.


canonical Wnt signaling pathway involved in stem cell proliferation

Any canonical Wnt signaling pathway that is involved in stem cell proliferation.


WNT3A_HUMAN Protein Wnt-3a (sprot)

A protein Wnt-3a that is encoded in the genome of human.


Wnt signaling pathway involved in forebrain neuroblast division

The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.


positive regulation of mesodermal cell fate specification

Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification.


paraxial mesodermal cell fate commitment

The process in which a cell becomes committed to become a paraxial mesoderm cell.


axis elongation involved in somitogenesis

The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis.


calcium ion transmembrane transport via low voltage-gated calcium channel

A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel.


positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation.


WNT4_HUMAN Protein Wnt-4 (sprot)

A protein Wnt-4 that is encoded in the genome of human.


female sex determination

The specification of female sex of an individual organism.


negative regulation of testicular blood vessel morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle.


metanephric nephron morphogenesis

The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros.


negative regulation of male gonad development

Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development.


positive regulation of cortisol biosynthetic process

Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process.


negative regulation of androgen biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process.


negative regulation of testosterone biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process.


WNT7B_HUMAN Protein Wnt-7b (sprot)

A protein Wnt-7b that is encoded in the genome of human.


establishment or maintenance of polarity of embryonic epithelium

Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo.


regulation of cell projection size

A process that modulates the size of a cell projection.


chemoattraction of dopaminergic neuron axon

The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal.


lobar bronchus development

The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi.


developmental growth involved in morphogenesis

The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.


outer medullary collecting duct development

The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla.


inner medullary collecting duct development

The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla.


RP1_HUMAN Oxygen-regulated protein 1 (sprot)

An oxygen-regulated protein 1 that is encoded in the genome of human.


NETR_HUMAN Neurotrypsin (sprot)

A neurotrypsin that is encoded in the genome of human.


CLD15_HUMAN Claudin-15 (sprot)

A claudin-15 that is encoded in the genome of human.


CLD6_HUMAN Claudin-6 (sprot)

A claudin-6 that is encoded in the genome of human.


CLD8_HUMAN Claudin-8 (sprot)

A claudin-8 that is encoded in the genome of human.


CLD12_HUMAN Claudin-12 (sprot)

A claudin-12 that is encoded in the genome of human.


CLD17_HUMAN Claudin-17 (sprot)

A claudin-17 that is encoded in the genome of human.


BACE1_HUMAN Beta-secretase 1 (sprot)

A beta-secretase 1 that is encoded in the genome of human.


beta-aspartyl-peptidase activity

Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide.


Golgi-associated vesicle lumen

The volume enclosed by the membrane of a Golgi-associated vesicle.


EP3B_HUMAN Epididymal secretory protein E3-beta (sprot)

An epididymal secretory protein E3-beta that is encoded in the genome of human.


CLD18_HUMAN Claudin-18 (sprot)

A claudin-18 that is encoded in the genome of human.


tight junction organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.


CLD20_HUMAN Claudin-20 (sprot)

A claudin-20 that is encoded in the genome of human.


GSC_HUMAN Homeobox protein goosecoid (sprot)

A homeobox protein goosecoid that is encoded in the genome of human.


DHB7_HUMAN 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (sprot)

A 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 that is encoded in the genome of human.


BCAR1_HUMAN Breast cancer anti-estrogen resistance protein 1 (sprot)

A breast cancer anti-estrogen resistance protein 1 that is encoded in the genome of human.


STX17_HUMAN Syntaxin-17 (sprot)

A syntaxin-17 that is encoded in the genome of human.


endoplasmic reticulum-Golgi intermediate compartment organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment.


NRG3_HUMAN Pro-neuregulin-3, membrane-bound isoform (sprot)

A pro-neuregulin-3, membrane-bound isoform that is encoded in the genome of human.


chemorepulsion involved in interneuron migration from the subpallium to the cortex

The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex.


ERBB4 signaling pathway

The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


RBM11_HUMAN Splicing regulator RBM11 (sprot)

A splicing regulator RBM11 that is encoded in the genome of human.


H2BFS_HUMAN Histone H2B type F-S (sprot)

A histone H2B type F-S that is encoded in the genome of human.


PIGP_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (sprot)

A phosphatidylinositol N-acetylglucosaminyltransferase subunit P that is encoded in the genome of human.


DSCR6_HUMAN Protein ripply3 (sprot)

A protein ripply3 that is encoded in the genome of human.


G6PT2_HUMAN Glucose-6-phosphate exchanger SLC37A1 (sprot)

A glucose-6-phosphate exchanger SLC37A1 that is encoded in the genome of human.


HUNK_HUMAN Hormonally up-regulated neu tumor-associated kinase (sprot)

A hormonally up-regulated neu tumor-associated kinase that is encoded in the genome of human.


SIK1_HUMAN Serine/threonine-protein kinase SIK1 (sprot)

A serine/threonine-protein kinase SIK1 that is encoded in the genome of human.


regulation of myotube differentiation

Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


negative regulation of triglyceride biosynthetic process

Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.


RWD2B_HUMAN RWD domain-containing protein 2B (sprot)

An RWD domain-containing protein 2B that is encoded in the genome of human.


PRD15_HUMAN PR domain zinc finger protein 15 (sprot)

A PR domain zinc finger protein 15 that is encoded in the genome of human.


SOX8_HUMAN Transcription factor SOX-8 (sprot)

A transcription factor SOX-8 that is encoded in the genome of human.


UBS3A_HUMAN Ubiquitin-associated and SH3 domain-containing protein A (sprot)

A ubiquitin-associated and SH3 domain-containing protein A that is encoded in the genome of human.


CF298_HUMAN Cilia- and flagella-associated protein 298 (sprot)

A protein that is a translation product of the CFAP298 gene in human.


regulation of cilium movement

Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.


M3KCL_HUMAN MAP3K7 C-terminal-like protein (sprot)

A MAP3K7 C-terminal-like protein that is encoded in the genome of human.


RIPK4_HUMAN Receptor-interacting serine/threonine-protein kinase 4 (sprot)

A receptor-interacting serine/threonine-protein kinase 4 that is encoded in the genome of human.


WDR4_HUMAN tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (sprot)

A tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 that is encoded in the genome of human.


tRNA (guanine-N7)-methylation

The process whereby a guanine in a tRNA is methylated at the N7 position of guanine.


tRNA methyltransferase complex

A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.


tRNA (m7G46) methyltransferase complex

A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat).


TBX4_HUMAN T-box transcription factor TBX4 (sprot)

A T-box transcription factor TBX4 that is encoded in the genome of human.


SCND1_HUMAN SCAN domain-containing protein 1 (sprot)

A SCAN domain-containing protein 1 that is encoded in the genome of human.


JAM2_HUMAN Junctional adhesion molecule B (sprot)

A junctional adhesion molecule B that is encoded in the genome of human.


hematopoietic stem cell migration to bone marrow

The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.


positive regulation of lymphocyte migration

Any process that activates or increases the frequency, rate or extent of lymphocyte migration.


TMM33_HUMAN Transmembrane protein 33 (sprot)

A transmembrane protein 33 that is encoded in the genome of human.


regulation of endoplasmic reticulum tubular network organization

Any process that modulates the frequency, rate or extent of endoplasmic reticulum tubular network organization.


NAC3_HUMAN Sodium/calcium exchanger 3 (sprot)

A sodium/calcium exchanger 3 that is encoded in the genome of human.


monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential

Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.


SYJ2B_HUMAN Synaptojanin-2-binding protein (sprot)

A synaptojanin-2-binding protein that is encoded in the genome of human.


GEMI4_HUMAN Gem-associated protein 4 (sprot)

A gem-associated protein 4 that is encoded in the genome of human.


EVC_HUMAN EvC complex member EVC (sprot)

An EvC complex member EVC that is encoded in the genome of human.


KLF3_HUMAN Krueppel-like factor 3 (sprot)

A krueppel-like factor 3 that is encoded in the genome of human.


PCBP3_HUMAN Poly(rC)-binding protein 3 (sprot)

A poly(rC)-binding protein 3 that is encoded in the genome of human.


C-rich single-stranded DNA binding

Binding to C-rich, single-stranded DNA.


PCBP4_HUMAN Poly(rC)-binding protein 4 (sprot)

A poly(rC)-binding protein 4 that is encoded in the genome of human.


TMPS3_HUMAN Transmembrane protease serine 3 (sprot)

A transmembrane protease serine 3 that is encoded in the genome of human.


RAB38_HUMAN Ras-related protein Rab-38 (sprot)

A Ras-related protein Rab-38 that is encoded in the genome of human.


AP-1 adaptor complex binding

Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).


AP-3 adaptor complex binding

Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).


BLOC-2 complex binding

Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.


CAR18_HUMAN Caspase recruitment domain-containing protein 18 (sprot)

A caspase recruitment domain-containing protein 18 that is encoded in the genome of human.


RAB25_HUMAN Ras-related protein Rab-25 (sprot)

A Ras-related protein Rab-25 that is encoded in the genome of human.


pseudopodium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.


pseudopodium membrane

The portion of the plasma membrane surrounding a pseudopodium.


CORO7_HUMAN Coronin-7 (sprot)

A coronin-7 that is encoded in the genome of human.


TCTA_HUMAN T-cell leukemia translocation-altered gene protein (sprot)

A T-cell leukemia translocation-altered gene protein that is encoded in the genome of human.


osteoclast fusion

The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast.


CLD2_HUMAN Claudin-2 (sprot)

A claudin-2 that is encoded in the genome of human.


NU107_HUMAN Nuclear pore complex protein Nup107 (sprot)

A nuclear pore complex protein Nup107 that is encoded in the genome of human.


GSDMD_HUMAN Gasdermin-D (sprot)

A gasdermin-D that is encoded in the genome of human.


SNX16_HUMAN Sorting nexin-16 (sprot)

A sorting nexin-16 that is encoded in the genome of human.


RGS8_HUMAN Regulator of G-protein signaling 8 (sprot)

A regulator of G-protein signaling 8 that is encoded in the genome of human.


regulation of dopamine receptor signaling pathway

Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.


SELB_HUMAN Selenocysteine-specific elongation factor (sprot)

A selenocysteine-specific elongation factor that is encoded in the genome of human.


CXA9_HUMAN Gap junction alpha-9 protein (sprot)

A gap junction alpha-9 protein that is encoded in the genome of human.


FBXW4_HUMAN F-box/WD repeat-containing protein 4 (sprot)

An F-box/WD repeat-containing protein 4 that is encoded in the genome of human.


KCNKA_HUMAN Potassium channel subfamily K member 10 (sprot)

A potassium channel subfamily K member 10 that is encoded in the genome of human.


CABP4_HUMAN Calcium-binding protein 4 (sprot)

A calcium-binding protein 4 that is encoded in the genome of human.


photoreceptor cell morphogenesis

The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.


SESN2_HUMAN Sestrin-2 (sprot)

A sestrin-2 that is encoded in the genome of human.


sulfiredoxin activity

Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.


regulation of response to reactive oxygen species

Any process that modulates the frequency, rate or extent of response to reactive oxygen species.


negative regulation of translation in response to endoplasmic reticulum stress

Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.


SESN3_HUMAN Sestrin-3 (sprot)

A sestrin-3 that is encoded in the genome of human.


TORC2 signaling

A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.


FOXL2_HUMAN Forkhead box protein L2 (sprot)

A forkhead box protein L2 that is encoded in the genome of human.


cysteine-type endopeptidase regulator activity involved in apoptotic process

Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.


female somatic sex determination

The determination of sex and sexual phenotypes in a female organism's soma.


granulosa cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals.


ISK7_HUMAN Serine protease inhibitor Kazal-type 7 (sprot)

A serine protease inhibitor Kazal-type 7 that is encoded in the genome of human.


EPIPL_HUMAN Epiplakin (sprot)

An epiplakin that is encoded in the genome of human.


negative regulation of keratinocyte migration

Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration.


regulation of epithelium regeneration

Any process that modulates the frequency, rate or extent of epithelium regeneration.


perinucleolar compartment

The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC.


INHBE_HUMAN Inhibin beta E chain (sprot)

An activin/inhibin beta E chain that is encoded in the genome of human.


OR1D5_HUMAN Olfactory receptor 1D5 (sprot)

An olfactory receptor 1D5 that is encoded in the genome of human.


OR2B6_HUMAN Olfactory receptor 2B6 (sprot)

An olfactory receptor 2B6 that is encoded in the genome of human.


OR4D2_HUMAN Olfactory receptor 4D2 (sprot)

An olfactory receptor 4D2 that is encoded in the genome of human.


O10A3_HUMAN Olfactory receptor 10A3 (sprot)

An olfactory receptor 10A3 that is encoded in the genome of human.


O12D2_HUMAN Olfactory receptor 12D2 (sprot)

An olfactory receptor 12D2 that is encoded in the genome of human.


LOXL3_HUMAN Lysyl oxidase homolog 3 (sprot)

A lysyl oxidase homolog 3 that is encoded in the genome of human.


fibronectin fibril organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a fibronectin fibril.


negative regulation of T-helper 17 cell lineage commitment

Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment.


PROK1_HUMAN Prokineticin-1 (sprot)

A prokineticin-1 that is encoded in the genome of human.


vascular endothelial cell proliferation

The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population.


VSX2_HUMAN Visual system homeobox 2 (sprot)

A visual system homeobox 2 that is encoded in the genome of human.


ZN121_HUMAN Zinc finger protein 121 (sprot)

A zinc finger protein 121 that is encoded in the genome of human.


ANTR2_HUMAN Anthrax toxin receptor 2 (sprot)

An anthrax toxin receptor 2 that is encoded in the genome of human.


MLF1_HUMAN Myeloid leukemia factor 1 (sprot)

A myeloid leukemia factor 1 that is encoded in the genome of human.


ATS12_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 12 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 12 that is encoded in the genome of human.


proteoglycan catabolic process

The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


negative regulation of hepatocyte growth factor receptor signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway.


negative regulation of cellular response to hepatocyte growth factor stimulus

Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus.


NXPH1_HUMAN Neurexophilin-1 (sprot)

A neurexophilin-1 that is encoded in the genome of human.


CLRN1_HUMAN Clarin-1 (sprot)

A clarin-1 that is encoded in the genome of human.


equilibrioception

The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion.


FAM3B_HUMAN Protein FAM3B (sprot)

A protein FAM3B that is encoded in the genome of human.


SIM11_HUMAN Small integral membrane protein 11 (sprot)

A small integral membrane protein 11 that is encoded in the genome of human.


CU067_HUMAN Uncharacterized protein encoded by LINC01547 (sprot)

A protein that is a translation product of the LINC01547 gene in human.


MTPN_HUMAN Myotrophin (sprot)

A myotrophin that is encoded in the genome of human.


positive regulation of macromolecule biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


regulation of barbed-end actin filament capping

Any process that modulates the frequency, rate or extent of barbed-end actin filament capping.


FXYD7_HUMAN FXYD domain-containing ion transport regulator 7 (sprot)

An FXYD domain-containing ion transport regulator 7 that is encoded in the genome of human.


regulation of monoatomic ion transport

Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


FXYD8_HUMAN Putative FXYD domain-containing ion transport regulator 8 (sprot)


YBEY_HUMAN Endoribonuclease YbeY (sprot)

An rRNA maturation factor homolog that is encoded in the genome of human.


EVA1C_HUMAN Protein eva-1 homolog C (sprot)

A protein FAM176C that is encoded in the genome of human.


S26A5_HUMAN Prestin (sprot)

A prestin that is encoded in the genome of human.


response to salicylic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus.


lateral wall of outer hair cell

The lateral wall of an outer hair cell (OHC) is a unique trilaminate composite consisting of the plasma membrane, an underlying cytoskeletal network containing an actin-spectrin cortical lattice, and an adjacent system of circumferential lamellar organelles known as the subsurface cisternae.


TIRAP_HUMAN Toll/interleukin-1 receptor domain-containing adapter protein (sprot)

A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human.


Toll-like receptor 2 binding

Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.


positive regulation of interleukin-15 production

Any process that activates or increases the frequency, rate, or extent of interleukin-15 production.


TIRAP-dependent toll-like receptor 4 signaling pathway

The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


positive regulation of chemokine (C-X-C motif) ligand 1 production

Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production.


RHBL3_HUMAN Rhomboid-related protein 3 (sprot)

A rhomboid-related protein 3 that is encoded in the genome of human.


H2B1D_HUMAN Histone H2B type 1-D (sprot)

A histone H2B type 1-D that is encoded in the genome of human.


DSCR9_HUMAN Down syndrome critical region protein 9 (sprot)

A Down syndrome critical region protein 9 that is encoded in the genome of human.


DSC10_HUMAN Down syndrome critical region protein 10 (sprot)

A Down syndrome critical region protein 10 that is encoded in the genome of human.


RTP1_HUMAN Receptor-transporting protein 1 (sprot)

A receptor-transporting protein 1 that is encoded in the genome of human.


olfactory receptor binding

Binding to an olfactory receptor.


NLRP6_HUMAN NACHT, LRR and PYD domains-containing protein 6 (sprot)

A NACHT, LRR and PYD domains-containing protein 6 that is encoded in the genome of human.


regulation of mucus secretion

Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.


NLRP6 inflammasome complex assembly

The aggregation, arrangement and bonding together of a set of components to form a NLRP6 inflammasome complex.


non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.


NLRP6 inflammasome complex

An inflammasome complex that consists of NLRP6, PYCARD/ASC and caspase-1 or caspase-4/caspase-11.


NAL11_HUMAN NACHT, LRR and PYD domains-containing protein 11 (sprot)

A NACHT, LRR and PYD domains-containing protein 11 that is encoded in the genome of human.


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor.


NAL12_HUMAN NACHT, LRR and PYD domains-containing protein 12 (sprot)

A NACHT, LRR and PYD domains-containing protein 12 that is encoded in the genome of human.


regulation of interleukin-18 production

Any process that modulates the frequency, rate, or extent of interleukin-18 production.


negative regulation of Toll signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway.


NALP5_HUMAN NACHT, LRR and PYD domains-containing protein 5 (sprot)

A NACHT, LRR and PYD domains-containing protein 5 that is encoded in the genome of human.


regulation of localization

Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.


establishment of organelle localization

The directed movement of an organelle to a specific location.


CHM4P_HUMAN Putative charged multivesicular body protein 4B-like protein CHMP4BP1 (sprot)


STAR6_HUMAN StAR-related lipid transfer protein 6 (sprot)

A StAR-related lipid transfer protein 6 that is encoded in the genome of human.


DAOA_HUMAN D-amino acid oxidase activator (sprot)

A D-amino acid oxidase activator that is encoded in the genome of human.


negative regulation of D-amino-acid oxidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of D-amino-acid oxidase activity.


RAB15_HUMAN Ras-related protein Rab-15 (sprot)

A Ras-related protein Rab-15 that is encoded in the genome of human.


TPPP2_HUMAN Tubulin polymerization-promoting protein family member 2 (sprot)

A tubulin polymerization-promoting protein family member 2 that is encoded in the genome of human.


regulation of flagellated sperm motility

Any process that modulates the frequency, rate or extent of flagellated sperm motility.


ATS20_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 20 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 20 that is encoded in the genome of human.


T2R38_HUMAN Taste receptor type 2 member 38 (sprot)

A taste receptor type 2 member 38 that is encoded in the genome of human.


bitter taste receptor activity

Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste.


T2R39_HUMAN Taste receptor type 2 member 39 (sprot)

A taste receptor type 2 member 39/139 that is encoded in the genome of human.


T2R40_HUMAN Taste receptor type 2 member 40 (sprot)

A taste receptor type 2 member 40 that is encoded in the genome of human.


T2R41_HUMAN Taste receptor type 2 member 41 (sprot)

A taste receptor type 2 member 41 that is encoded in the genome of human.


T2R43_HUMAN Taste receptor type 2 member 43 (sprot)

A taste receptor type 2 member 43 that is encoded in the genome of human.


taste receptor activity

Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.


T2R31_HUMAN Taste receptor type 2 member 31 (sprot)

A taste receptor type 2 member 31 that is encoded in the genome of human.


T2R45_HUMAN Taste receptor type 2 member 45 (sprot)

A taste receptor type 2 member 45 that is encoded in the genome of human.


T2R46_HUMAN Taste receptor type 2 member 46 (sprot)

A taste receptor type 2 member 46 that is encoded in the genome of human.


T2R30_HUMAN Taste receptor type 2 member 30 (sprot)

A taste receptor type 2 member 30 that is encoded in the genome of human.


T2R19_HUMAN Taste receptor type 2 member 19 (sprot)

A taste receptor type 2 member 19 that is encoded in the genome of human.


T2R20_HUMAN Taste receptor type 2 member 20 (sprot)

A taste receptor type 2 member 20 that is encoded in the genome of human.


T2R50_HUMAN Taste receptor type 2 member 50 (sprot)

A taste receptor type 2 member 50 that is encoded in the genome of human.


T2R60_HUMAN Taste receptor type 2 member 60 (sprot)

A taste receptor type 2 member 60/135 that is encoded in the genome of human.


sensory perception of bitter taste

The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


FXYD4_HUMAN FXYD domain-containing ion transport regulator 4 (sprot)

An FXYD domain-containing ion transport regulator 4 that is encoded in the genome of human.


DEF1_HUMAN Neutrophil defensin 1 (sprot)

A protein that is a translation product of any of the following genes in human: DEFA1/DEFA1B.


DEF3_HUMAN Neutrophil defensin 3 (sprot)

A protein that is a translation product of the DEFA3 gene in human.


GBG2_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (sprot)

A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 that is encoded in the genome of human.


MNARL_HUMAN Major intrinsically disordered NOTCH2-binding receptor 1-like (sprot)

A major intrinsically disordered NOTCH2-binding receptor 1-like that is encoded in the genome of human.


AP3S2_HUMAN AP-3 complex subunit sigma-2 (sprot)

An AP-3 complex subunit sigma-2 (human), isoforms 1 and 3.


Golgi to vacuole transport

The directed movement of substances from the Golgi to the vacuole.


GPX6_HUMAN Glutathione peroxidase 6 (sprot)

A glutathione peroxidase 6 that is encoded in the genome of human.


SELV_HUMAN Selenoprotein V (sprot)

A selenoprotein V that is encoded in the genome of human.


Z280A_HUMAN Zinc finger protein 280A (sprot)

A zinc finger protein 280A that is encoded in the genome of human.


BPIB3_HUMAN BPI fold-containing family B member 3 (sprot)

A BPI fold-containing family B member 3 that is encoded in the genome of human.


BPIB4_HUMAN BPI fold-containing family B member 4 (sprot)

A BPI fold-containing family B member 4 that is encoded in the genome of human.


D131A_HUMAN Beta-defensin 131A (sprot)

A beta-defensin 131A that is encoded in the genome of human.


LIRA4_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 4 (sprot)

A leukocyte immunoglobulin-like receptor subfamily A member 4 that is encoded in the genome of human.


negative regulation of toll-like receptor 7 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway.


negative regulation of toll-like receptor 9 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway.


Fc-epsilon receptor I complex

A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE.


DJB13_HUMAN DnaJ homolog subfamily B member 13 (sprot)

A DnaJ homolog subfamily B member 13 that is encoded in the genome of human.


axonemal central apparatus assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus.


OR2B8_HUMAN Putative olfactory receptor 2B8 (sprot)


ZN445_HUMAN Zinc finger protein 445 (sprot)

A zinc finger protein 445 that is encoded in the genome of human.


epigenetic programing of female pronucleus

The global programming of epigenetic modifications in the female pronucleus of the newly fertilized zygote. The maternal genome is protected from global DNA demethylation before the first division of the zygote, and instead undergoes passive, replication-dependent demethylation during early embryogenesis, arising from inhibition of the DNA maintenance methyltransferase Dnmt1.


MCCD1_HUMAN Mitochondrial coiled-coil domain protein 1 (sprot)

A mitochondrial coiled-coil domain protein 1 that is encoded in the genome of human.


KR121_HUMAN Keratin-associated protein 12-1 (sprot)

A keratin-associated protein 12-1 that is encoded in the genome of human.


KR122_HUMAN Keratin-associated protein 12-2 (sprot)

A keratin-associated protein 12-2 that is encoded in the genome of human.


ARPC4_HUMAN Actin-related protein 2/3 complex subunit 4 (sprot)

An actin-related protein 2/3 complex subunit 4 that is encoded in the genome of human.


ELOF1_HUMAN Transcription elongation factor 1 homolog (sprot)

A transcription elongation factor 1 that is encoded in the genome of human.


APC15_HUMAN Anaphase-promoting complex subunit 15 (sprot)

An anaphase-promoting complex subunit 15 that is encoded in the genome of human.


HILS1_HUMAN Putative spermatid-specific linker histone H1-like protein (sprot)

A putative spermatid-specific linker histone H1-like protein that is encoded in the genome of human.


KR10A_HUMAN Keratin-associated protein 10-10 (sprot)

A keratin-associated protein 10-10 that is encoded in the genome of human.


DEFB1_HUMAN Beta-defensin 1 (sprot)

A beta-defensin 1 that is encoded in the genome of human.


microvesicle

An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm.


CD81_HUMAN CD81 antigen (sprot)

A CD81 molecule that is encoded in the genome of human.


macrophage fusion

The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell.


CD4-positive, alpha-beta T cell costimulation

The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation.


positive regulation of protein exit from endoplasmic reticulum

Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum.


positive regulation of receptor clustering

Any process that activates or increases the frequency, rate or extent of receptor clustering.


positive regulation of protein catabolic process in the vacuole

Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole.


positive regulation of adaptive immune memory response

Any process that activates or increases the frequency, rate or extent of adaptive immune memory response.


SC61G_HUMAN Protein transport protein Sec61 subunit gamma (sprot)

A protein transport protein Sec61 subunit gamma that is encoded in the genome of human.


RNAS9_HUMAN Inactive ribonuclease-like protein 9 (sprot)

A ribonuclease-like protein 9 that is encoded in the genome of human.


TPIS_HUMAN Triosephosphate isomerase (sprot)

A triosephosphate isomerase that is encoded in the genome of human.


triose-phosphate isomerase activity

Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.


methylglyoxal synthase activity

Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate.


methylglyoxal biosynthetic process

The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.


MYPR_HUMAN Myelin proteolipid protein (sprot)

A myelin proteolipid protein that is encoded in the genome of human.


AMPA selective glutamate receptor signaling pathway

The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.


positive regulation of calcium ion transmembrane transport

Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport.


EIF3E_HUMAN Eukaryotic translation initiation factor 3 subunit E (sprot)

A eukaryotic translation initiation factor 3 subunit E that is encoded in the genome of human.


eukaryotic translation initiation factor 3 complex, eIF3e

An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.


NANO2_HUMAN Nanos homolog 2 (sprot)

A nanos homolog 2 that is encoded in the genome of human.


NANO3_HUMAN Nanos homolog 3 (sprot)

A nanos homolog 3 that is encoded in the genome of human.


KR123_HUMAN Keratin-associated protein 12-3 (sprot)

A keratin-associated protein 12-3 that is encoded in the genome of human.


KR124_HUMAN Keratin-associated protein 12-4 (sprot)

A keratin-associated protein 12-4 that is encoded in the genome of human.


KR101_HUMAN Keratin-associated protein 10-1 (sprot)

A keratin-associated protein 10-1 that is encoded in the genome of human.


KR102_HUMAN Keratin-associated protein 10-2 (sprot)

A keratin-associated protein 10-2 that is encoded in the genome of human.


KR103_HUMAN Keratin-associated protein 10-3 (sprot)

A keratin-associated protein 10-3 that is encoded in the genome of human.


KR105_HUMAN Keratin-associated protein 10-5 (sprot)

A keratin-associated protein 10-5 that is encoded in the genome of human.


KR106_HUMAN Keratin-associated protein 10-6 (sprot)

A keratin-associated protein 10-6 that is encoded in the genome of human.


KR104_HUMAN Keratin-associated protein 10-4 (sprot)

A keratin-associated protein 10-4 that is encoded in the genome of human.


KR107_HUMAN Keratin-associated protein 10-7 (sprot)

A keratin-associated protein 10-7 that is encoded in the genome of human.


KR108_HUMAN Keratin-associated protein 10-8 (sprot)

A keratin-associated protein 10-8 that is encoded in the genome of human.


KR109_HUMAN Keratin-associated protein 10-9 (sprot)

A keratin-associated protein 10-9 that is encoded in the genome of human.


KR10B_HUMAN Keratin-associated protein 10-11 (sprot)

A keratin-associated protein 10-11 that is encoded in the genome of human.


KR10C_HUMAN Keratin-associated protein 10-12 (sprot)

A keratin-associated protein 10-12 that is encoded in the genome of human.


SC61B_HUMAN Protein transport protein Sec61 subunit beta (sprot)

A protein transport protein Sec61 subunit beta that is encoded in the genome of human.


endoplasmic reticulum Sec complex

An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex.


PTEN_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (sprot)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN that is encoded in the genome of human.


Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate.


Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.


phosphatidylinositol phosphate phosphatase activity

Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate.


spindle assembly involved in female meiosis

The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.


regulation of cellular component size

A process that modulates the size of a cellular component.


rhythmic synaptic transmission

Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit.


postsynaptic density assembly

The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.


negative regulation of synaptic vesicle clustering

Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle clustering.


EFC1_HUMAN Endogenous retrovirus group FC1 Env polyprotein (sprot)

A protein that is a translation product of the ERVFC1 gene in human.


syncytium formation by plasma membrane fusion

The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


SYCY2_HUMAN Syncytin-2 (sprot)

A syncytin-2 that is encoded in the genome of human.


ERB1_HUMAN Endogenous retrovirus group PABLB member 1 Env polyprotein (sprot)

A protein that is a translation product of the ERVPABLB-1 gene in human.


PP4C_HUMAN Serine/threonine-protein phosphatase 4 catalytic subunit (sprot)

A serine/threonine-protein phosphatase 4 catalytic subunit that is encoded in the genome of human.


protein phosphatase 4 complex

A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.


GBRL2_HUMAN Gamma-aminobutyric acid receptor-associated protein-like 2 (sprot)

A gamma-aminobutyric acid receptor-associated protein-like 2 that is encoded in the genome of human.


IL2_HUMAN Interleukin-2 (sprot)

An interleukin-2 that is encoded in the genome of human.


kappa-type opioid receptor binding

Binding to a kappa-type opioid receptor.


response to tacrolimus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus.


ROMO1_HUMAN Reactive oxygen species modulator 1 (sprot)

A reactive oxygen species modulator 1 that is encoded in the genome of human.


UB2G2_HUMAN Ubiquitin-conjugating enzyme E2 G2 (sprot)

A ubiquitin-conjugating enzyme E2 G2 that is encoded in the genome of human.


negative regulation of retrograde protein transport, ER to cytosol

Any process that stops, prevents or reduces the frequency, rate or extent of retrograde protein transport, ER to cytosol.


CTXN1_HUMAN Cortexin-1 (sprot)

A cortexin-1 that is encoded in the genome of human.


EFC2_HUMAN Endogenous retrovirus group FC1 member 1 Env polyprotein (sprot)

A protein that is a translation product of the ERVFC1-1 gene in human.


MYL6_HUMAN Myosin light polypeptide 6 (sprot)

A myosin light polypeptide 6 that is encoded in the genome of human.


PROF3_HUMAN Profilin-3 (sprot)

A profilin-3 that is encoded in the genome of human.


ACTB_HUMAN Actin, cytoplasmic 1 (sprot)

An actin, cytoplasmic 1 that is encoded in the genome of human.


structural constituent of postsynaptic actin cytoskeleton

The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton.


positive regulation of norepinephrine uptake

Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell.


protein localization to adherens junction

Any process in which a protein is transported to, and/or maintained at the adherens junction.


cellular response to cytochalasin B

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus.


dense body

An electron dense body which may contain granules.


RAC3_HUMAN Ras-related C3 botulinum toxin substrate 3 (sprot)

A Ras-related C3 botulinum toxin substrate 3 that is encoded in the genome of human.


regulation of neuron maturation

Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.


cerebral cortex GABAergic interneuron development

The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.


C1QT8_HUMAN Complement C1q tumor necrosis factor-related protein 8 (sprot)

A complement C1q tumor necrosis factor-related protein 8 that is encoded in the genome of human.


IF4A1_HUMAN Eukaryotic initiation factor 4A-I (sprot)

A eukaryotic initiation factor 4A-I that is encoded in the genome of human.


cytoplasmic translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


ZP1_HUMAN Zona pellucida sperm-binding protein 1 (sprot)

A zona pellucida sperm-binding protein 1 that is encoded in the genome of human.


RS20_HUMAN Small ribosomal subunit protein uS10 (sprot)

A 40S ribosomal protein S20 that is encoded in the genome of human.


SNP25_HUMAN Synaptosomal-associated protein 25 (sprot)

A synaptosomal-associated protein 25 that is encoded in the genome of human.


exocytic insertion of neurotransmitter receptor to postsynaptic membrane

The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion.


presynaptic dense core vesicle exocytosis

The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.


A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor.


extrinsic component of presynaptic membrane

The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).


A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).


PRPS1_HUMAN Ribose-phosphate pyrophosphokinase 1 (sprot)

A ribose-phosphate pyrophosphokinase 1 that is encoded in the genome of human.


pyrimidine nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


hypoxanthine biosynthetic process

The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.


GPR85_HUMAN Probable G-protein coupled receptor 85 (sprot)

A probable G-protein coupled receptor 85 that is encoded in the genome of human.


PSA6_HUMAN Proteasome subunit alpha type-6 (sprot)

A proteasome subunit alpha type-6 that is encoded in the genome of human.


purine ribonucleoside triphosphate binding

Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.


S10AA_HUMAN Protein S100-A10 (sprot)

A protein S100-A10 that is encoded in the genome of human.


CDC42_HUMAN Cell division control protein 42 homolog (sprot)

A cell division control protein 42 that is encoded in the genome of human.


positive regulation of synapse structural plasticity

Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.


actin filament branching

The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments.


regulation of modification of postsynaptic structure

Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.


storage vacuole

A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.


Golgi transport complex

A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8.


DEST_HUMAN Destrin (sprot)

A destrin that is encoded in the genome of human.


GMFB_HUMAN Glia maturation factor beta (sprot)

A glia maturation factor beta that is encoded in the genome of human.


KTDAP_HUMAN Keratinocyte differentiation-associated protein (sprot)

A keratinocyte differentiation-associated protein that is encoded in the genome of human.


RAB8A_HUMAN Ras-related protein Rab-8A (sprot)

A Ras-related protein Rab-8A that is encoded in the genome of human.


Golgi vesicle fusion to target membrane

The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane.


SPCS3_HUMAN Signal peptidase complex subunit 3 (sprot)

A signal peptidase complex subunit 3 that is encoded in the genome of human.


signal peptidase complex

A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space.


SRP54_HUMAN Signal recognition particle subunit SRP54 (sprot)

A signal recognition particle 54 kDa protein that is encoded in the genome of human.


SRP-dependent cotranslational protein targeting to membrane, translocation

The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.


RAB4B_HUMAN Ras-related protein Rab-4B (sprot)

A Ras-related protein Rab-4B that is encoded in the genome of human.


RAB2A_HUMAN Ras-related protein Rab-2A (sprot)

A Ras-related protein Rab-2A that is encoded in the genome of human.


RAB5B_HUMAN Ras-related protein Rab-5B (sprot)

A Ras-related protein Rab-5B that is encoded in the genome of human.


CKS1_HUMAN Cyclin-dependent kinases regulatory subunit 1 (sprot)

A cyclin-dependent kinases regulatory subunit 1 that is encoded in the genome of human.


RAB10_HUMAN Ras-related protein Rab-10 (sprot)

A Ras-related protein Rab-10 that is encoded in the genome of human.


establishment of neuroblast polarity

The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.


establishment of protein localization to endoplasmic reticulum membrane

The directed movement of a protein to a specific location in the endoplasmic reticulum membrane.


endoplasmic reticulum tubular network

A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section.


CXCR4_HUMAN C-X-C chemokine receptor type 4 (sprot)

A C-X-C chemokine receptor type 4 that is encoded in the genome of human.


C-X-C motif chemokine 12 receptor activity

Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


neuron recognition

The process in which a neuronal cell in a multicellular organism interprets its surroundings.


regulation of viral process

Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts.


UB2D3_HUMAN Ubiquitin-conjugating enzyme E2 D3 (sprot)

A ubiquitin-conjugating enzyme E2 D3 that is encoded in the genome of human.


UBC12_HUMAN NEDD8-conjugating enzyme Ubc12 (sprot)

A NEDD8-conjugating enzyme Ubc12 that is encoded in the genome of human.


NEDD8 transferase activity

Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.