meiotic strand invasion involved in reciprocal meiotic recombination

The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.


type 1 orexin receptor binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to a type 1 orexin receptor.


JUN kinase phosphatase activity

Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.


RGPD4_HUMAN RanBP2-like and GRIP domain-containing protein 4 (sprot)

A RanBP2-like and GRIP domain-containing protein 4 that is encoded in the genome of human.


positive regulation of glutamate-cysteine ligase activity

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Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.


negative regulation of sequestering of calcium ion

Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


mitochondrial DNA-directed RNA polymerase complex

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A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form.


alkylbase DNA N-glycosylase activity

Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.


pyrimidine nucleobase biosynthetic process

The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


intracellular sodium activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification.


mitochondrial coenzyme A transmembrane transport

The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion.


GLCI1_HUMAN Glucocorticoid-induced transcript 1 protein (sprot)

A glucocorticoid-induced transcript 1 protein that is encoded in the genome of human.


establishment of cell polarity involved in ameboidal cell migration

The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.


D19P2_HUMAN Putative C-mannosyltransferase DPY19L2P2 (sprot)

A protein dpy-19 2-like 2 that is encoded in the genome of human.


SE1L2_HUMAN Protein sel-1 homolog 2 (sprot)

A protein sel-1 homolog 2 that is encoded in the genome of human.


A0A0G2JLQ3_HUMAN Killer cell immunoglobulin-like receptor (trembl)


nonfunctional rRNA decay

An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system.


glucagon receptor binding

Binding to a glucagon receptor.


meiotic DNA double-strand break processing

The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis.


N-terminal peptidyl-proline methylation

The methylation of the N-terminal proline of proteins.


Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine.


muscle cell fate specification

The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


steroid 7-alpha-hydroxylase activity

Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O.


RNA polymerase II, holoenzyme

A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters.


exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.


CXCR4 chemokine receptor binding

Binding to a CXCR4 chemokine receptor.


Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).


purine-specific nucleoside:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in).


A0A075B7D4_HUMAN Immunoglobulin kappa variable 1/OR2-108 (non-functional) (Fragment) (trembl)


sarcosine dehydrogenase activity

Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.


glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate.


glucosamine 6-phosphate N-acetyltransferase activity

Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+.


acid-amino acid ligase activity

Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.


A0A075B7D0_HUMAN Immunoglobulin heavy variable 1/OR15-1 (non-functional) (Fragment) (trembl)


DNA ligase III-XRCC1 complex

A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair.


telomere tethering at nuclear periphery

The process in which a telomere is maintained in a specific location at the nuclear periphery.


folic acid-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.


Ssh1 translocon complex

A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences.


DC122_HUMAN DDB1- and CUL4-associated factor 12-like protein 2 (sprot)

A DDB1- and CUL4-associated factor 12-like protein 2 that is encoded in the genome of human.


N-acetylglucosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.


mitotic cell cycle checkpoint signaling

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A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.


GOG8S_HUMAN Golgin subfamily A member 8S (sprot)

A protein that is a translation product of the GOLGA8S gene in human.


A0A0G2JNF4_HUMAN Killer cell immunoglobulin-like receptor, two Ig domains pseudogene 1 (trembl)


IQCF5_HUMAN IQ domain-containing protein F5 (sprot)

An IQ domain-containing protein F5 that is encoded in the genome of human.


SGE2P_HUMAN Putative SAGE1-like protein (sprot)


peroxisomal importomer complex

A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners.


CURI complex

A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.


LR14B_HUMAN Leucine-rich repeat-containing protein 14B (sprot)

A leucine-rich repeat-containing protein 14B that is encoded in the genome of human.


LRIQ4_HUMAN Leucine-rich repeat and IQ domain-containing protein 4 (sprot)

A leucine-rich repeat and IQ domain-containing protein 4 that is encoded in the genome of human.


LHPL6_HUMAN LHFPL tetraspan subfamily member 6 protein (sprot)

An LHFPL tetraspan subfamily member 6 protein that is encoded in the genome of human.


B7ZLF3_HUMAN C2H2-type domain-containing protein (trembl)


putrescine binding

Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.


Dbf4-dependent protein kinase complex

A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.


cytokine production involved in immune response

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.


negative regulation of GTP binding

Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding.


meiotic DNA integrity checkpoint signaling

A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.


Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate.


extrinsic component of postsynaptic early endosome membrane

The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


TM9S3_HUMAN Transmembrane 9 superfamily member 3 (sprot)

A transmembrane 9 superfamily member 3 that is encoded in the genome of human.


INT6L_HUMAN Integrator complex subunit 6-like (sprot)

An integrator complex subunit 6-like that is encoded in the genome of human.


The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.


nickel cation transmembrane transporter activity

Enables the transfer of nickel (Ni) cations from one side of a membrane to the other.


SATL1_HUMAN Spermidine/spermine N(1)-acetyltransferase-like protein 1 (sprot)

A spermidine/spermine N(1)-acetyltransferase-like protein 1 that is encoded in the genome of human.


RS10L_HUMAN Putative ribosomal protein eS10-like (sprot)


mu-type opioid receptor binding

Binding to a mu-type opioid receptor.


recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex

The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript.


snRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.


striated muscle dense body

A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.


A0A075B7D8_HUMAN Immunoglobulin heavy variable 3/OR15-7 (pseudogene) (Fragment) (trembl)


negative regulation of serine-type peptidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity.


CA5BL_HUMAN Putative inactive carbonic anhydrase 5B-like protein (sprot)


negative regulation of ribosome biogenesis

Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


RA1L3_HUMAN Heterogeneous nuclear ribonucleoprotein A1-like 3 (sprot)

A protein that is a translation product of the HNRNPA1L3 gene in human.


postsynaptic endocytic zone cytoplasmic component

The cytoplasmic component of the postsynaptic endocytic zone.


cysteinyl leukotriene receptor activity

Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine.


regulation of nervous system development

Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.


replication fork protection complex

A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.


CDP biosynthetic process

The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate.


N-terminal peptidyl-alanine methylation

The methylation of the N-terminal alanine of proteins.


microtubule-based transport

A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.


GOG8T_HUMAN Golgin subfamily A member 8T (sprot)

A protein that is a translation product of the GOLGA8T gene in human.


microtubule plus end polymerase

Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers.


lipoic acid binding

Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid.


dermatan sulfate metabolic process

The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues.


interleukin-8 production

The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


UAP1L_HUMAN UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (sprot)

A UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 that is encoded in the genome of human.


Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.


The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.


cyclic pyranopterin monophosphate synthase activity

Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.


PMIS2_HUMAN Transmembrane protein PMIS2 (sprot)

A protein that is a translation product of the PMIS2 gene in human.


clathrin-dependent endocytosis of virus by host cell

Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus.


fumarylacetoacetase activity

Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+.


LBHD1_HUMAN LBH domain-containing protein 1 (sprot)

A protein that is a translation product of the LBHD1 gene in human.


hepatocyte growth factor receptor activity

Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


G protein-coupled glutamate receptor binding

Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor).


SG1D4_HUMAN Secretoglobin family 1D member 4 (sprot)

A secretoglobin family 1D member 4 that is encoded in the genome of human.


RNA lariat debranching enzyme activator activity

Binds to and increases the activity of an RNA lariat debranching enzyme.


peptidyl-aspartic acid hydroxylation

The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid.


A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces.


protein O-GlcNAcylation via threonine

The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine.


ribonuclease MRP activity

Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.


neurotransmitter receptor transport postsynaptic membrane to endosome

Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome.


trans-synaptic signaling by neuropeptide, modulating synaptic transmission

Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.


Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA.


leucine biosynthetic process

The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.


snoRNA splicing

The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA.


CDP-glycerol diphosphatase activity

Catalysis of the reaction: CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H+.


dystroglycan complex

A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.


farnesyl diphosphate metabolic process

The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.


GRIN3_HUMAN G protein-regulated inducer of neurite outgrowth 3 (sprot)

A G protein-regulated inducer of neurite outgrowth 3 that is encoded in the genome of human.


FA53A_HUMAN Protein FAM53A (sprot)

A protein FAM53A that is encoded in the genome of human.


negative regulation of gastrin-induced gastric acid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of gastrin-induced gastric acid secretion.


guanine deaminase activity

Catalysis of the reaction: guanine + H2O = xanthine + NH3.


DNA replication proofreading

Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.


DNA replication preinitiation complex

A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.


regulatory ncRNA-mediated heterochromatin formation

A heterochromatin formation-based gene silencing process mediated by a regulatory non-coding RNA molecule that occur before the beginnning of trancription.


F135B_HUMAN Protein FAM135B (sprot)

A protein FAM135B that is encoded in the genome of human.


UDP-N-acetylgalactosamine transmembrane transporter activity

Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


nuclear polyadenylation-dependent snRNA catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA.


acireductone dioxygenase [iron(II)-requiring] activity

Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+.


dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.


dUTP catabolic process

The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate.


dihydroorotate dehydrogenase activity

Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.


secondary metabolic process

The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.


meiotic spindle assembly checkpoint signaling

A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle.


tRNA re-export from nucleus

The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export.


CRCC2_HUMAN Ciliary rootlet coiled-coil protein 2 (sprot)

A ciliary rootlet coiled-coil protein 2 that is encoded in the genome of human.


TT39C_HUMAN Tetratricopeptide repeat protein 39C (sprot)

A tetratricopeptide repeat protein 39C that is encoded in the genome of human.


SPE2B_HUMAN Speedy protein E2B (sprot)

A protein that is a translation product of the SPDYE2B gene in human.


translation reinitiation

A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.


HIR complex

A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p.


LRRC2_HUMAN Leucine-rich repeat-containing protein 2 (sprot)

A leucine-rich repeat-containing protein 2 that is encoded in the genome of human.


A0A0G2JLM5_HUMAN Killer cell immunoglobulin-like receptor 2DS5 (trembl)


PDCL2_HUMAN Phosducin-like protein 2 (sprot)

A phosducin-like protein 2 that is encoded in the genome of human.


TM202_HUMAN Transmembrane protein 202 (sprot)

A transmembrane protein 202 that is encoded in the genome of human.


nuclear pre-replicative complex

A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.


Rad6-Rad18 complex

A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity.


Rix1 complex

A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes.


sucrose biosynthetic process

The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside.


A0A0G2JNG1_HUMAN Killer cell immunoglobulin-like receptor 2DS5 (trembl)


radial glia guided migration of cerebellar granule cell

The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer.


negative cofactor 2 complex

A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.


ANKF1_HUMAN Ankyrin repeat and fibronectin type-III domain-containing protein 1 (sprot)

An ankyrin repeat and fibronectin type-III domain-containing protein 1 that is encoded in the genome of human.


The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate.


mitotic DNA damage checkpoint signaling

A signal transduction process involved in mitotic DNA damage checkpoint.


tyrosine biosynthetic process

The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.


rRNA cytidine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.


PRA26_HUMAN Putative PRAME family member 26 (sprot)


RGPD5_HUMAN RANBP2-like and GRIP domain-containing protein 5/6 (sprot)

A RANBP2-like and GRIP domain-containing protein 5/6 that is encoded in the genome of human.


oocyte axis specification

The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.


GKN3_HUMAN Gastrokine-3 (sprot)

A protein that is a translation product of the GKN3P gene in human.


fructosamine metabolic process

The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.


MutLalpha complex

A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.


ZY11A_HUMAN Protein zyg-11 homolog A (sprot)

A protein zyg-11 homolog A that is encoded in the genome of human.


MROH6_HUMAN Maestro heat-like repeat-containing protein family member 6 (sprot)

A protein that is a translation product of the MROH6 gene in human.


general transcription initiation factor activity

A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.


A0A0G2JPC4_HUMAN Killer cell immunoglobulin-like receptor (trembl)


SPD13_HUMAN Putative speedy protein E13 (sprot)


Sm-like protein family complex

A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles.


A0A075B7F0_HUMAN Immunoglobulin heavy variable 3/OR16-10 (non-functional) (Fragment) (trembl)


M4A15_HUMAN Membrane-spanning 4-domains subfamily A member 15 (sprot)

A membrane-spanning 4-domains subfamily A member 15 that is encoded in the genome of human.


phosphorus-oxygen lyase activity

Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


regulation of arginine metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


A0A0G2JP20_HUMAN PRAME family member 9 (trembl)


microtubule nucleation by interphase microtubule organizing center

The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation.


spindle attachment to meiosis I kinetochore

The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs.


regulation of heterochromatin formation

Any process that modulates the frequency, rate, extent or location of heterochromatin formation.


sterol delta7 reductase activity

Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol.


bent DNA binding

Binding to DNA in a bent conformation.


Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.


Mis6-Sim4 complex

A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.


gluconokinase activity

Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+.


meiotic DNA recombinase assembly

During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA.


TRAPPI protein complex

A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the core subunits of all TRAPP complexes in yeast.


negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly

Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly.


cytoplasmic U snRNP body

A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies.


SPDE3_HUMAN Speedy protein E3 (sprot)

A speedy protein E3 that is encoded in the genome of human.


brassinosteroid biosynthetic process

The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects.


CRGN_HUMAN Gamma-crystallin N (sprot)

A gamma-crystallin N that is encoded in the genome of human.


vitamin A import into cell

The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid.


LRC28_HUMAN Leucine-rich repeat-containing protein 28 (sprot)

A leucine-rich repeat-containing protein 28 that is encoded in the genome of human.


phosphoglycerate dehydrogenase activity

Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.


CRIS2_HUMAN Cysteine-rich secretory protein 2 (sprot)

A cysteine-rich secretory protein 2 that is encoded in the genome of human.


cone matrix sheath

A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments.


transverse filament

A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.


tRNA-type intron splice site recognition and cleavage

RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.


thiosulfate transport

The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


muscle attachment

The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).


XKR9_HUMAN XK-related protein 9 (sprot)

An XK-related protein 9 that is encoded in the genome of human.


acetolactate synthase activity

Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.


MROH1_HUMAN Maestro heat-like repeat-containing protein family member 1 (sprot)

A maestro heat-like repeat-containing protein family member 1 that is encoded in the genome of human.


cargo adaptor activity

Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery.


homogentisate catabolic process

The chemical reactions and pathways resulting in the breakdown of homogentisate.


GRTP1_HUMAN Growth hormone-regulated TBC protein 1 (sprot)

A growth hormone-regulated TBC protein 1 that is encoded in the genome of human.


pristanoyl-CoA oxidase activity

Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide.


riboflavin binding

Binding to riboflavin.


lateral element assembly

The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements.


nitrate transmembrane transporter activity

Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other.


D-xylose 1-dehydrogenase (NADP+) activity

Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + H+ + NADPH.


nucleotide-excision repair, DNA damage recognition

The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix.


interleukin-33 binding

Binding to interleukin-33.


tryptophan catabolic process to acetyl-CoA

The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA.


amidophosphoribosyltransferase activity

Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O.


maturation of 5S rRNA

Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule.


Noc2p-Noc3p complex

A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.


Catalysis of the reaction: carboxymethyluridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine.


A1 adenosine receptor binding

Binding to an A1 adenosine receptor.


ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.


telomere localization

Any process in which a telomere is transported to, and/or maintained in, a specific location.


A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M.


ribose phosphate metabolic process

The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar.


Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A).


RNA polymerase III assembly

The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex.


postsynaptic early endosome

An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.


DNA recombinase complex

A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA.


negative regulation of mRNA polyadenylation

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation.


chromosome localization to nuclear envelope involved in homologous chromosome segregation

The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis.


polyprenol biosynthetic process

The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.


F135A_HUMAN Protein FAM135A (sprot)

A protein FAM135A that is encoded in the genome of human.


cerebellar granular layer maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.


STPG3_HUMAN Protein STPG3 (sprot)

A protein STPG3 that is encoded in the genome of human.


heterotrimeric G-protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex.


presynaptic cytoskeleton

The portion of the cytoskeleton contained within the presynapse.


apelin receptor activity

Combining with the peptide apelin to initiate a change in cell activity.


IFM10_HUMAN Interferon-induced transmembrane protein 10 (sprot)

An interferon-induced transmembrane protein 10 that is encoded in the genome of human.


DJC25_HUMAN DnaJ homolog subfamily C member 25 (sprot)

A DnaJ homolog subfamily C member 25 that is encoded in the genome of human.


adenine biosynthetic process

The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.


SPD14_HUMAN Putative speedy protein E14 (sprot)


D-tyrosyl-tRNA(Tyr) deacylase activity

Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA.


perisynaptic extracellular matrix

The portion of the extracellular matrix that lies within the perisynaptic space.


regulation of plasma membrane sterol distribution

Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane.


Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A).


positive regulation of somatostatin secretion

Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


sodium-dependent multivitamin transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate.


parathyroid hormone receptor binding

Binding to a parathyroid hormone receptor.


regulation of integrin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.


vacuolar protein processing

Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.


immunoglobulin production involved in immunoglobulin-mediated immune response

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.


galanin receptor binding

Binding to a galanin receptor.


Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.


regulation of recycling endosome localization within postsynapse

Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.


COPII receptor activity

Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.


nuclear migration along microtubule

The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.


dTDP-glucose 4,6-dehydratase activity

Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.


D-serine transport

The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


MSD1_HUMAN Myb/SANT-like DNA-binding domain-containing protein 1 (sprot)

A Myb/SANT-like DNA-binding domain-containing protein 1 that is encoded in the genome of human.


actin filament bundle organization

A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.


synapse assembly involved in innervation

The assembly of a synapse within a target tissue in which a nerve is invading.


substance K receptor activity

Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity.


TM209_HUMAN Transmembrane protein 209 (sprot)

A transmembrane protein 209 that is encoded in the genome of human.


histone H3 deacetylation

The modification of histone H3 by the removal of one or more acetyl groups.


phosphatidylinositol 3-kinase complex, class III, type II

A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.


D-alanine transport

The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


RNA transmembrane transporter activity

Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.


SPD9_HUMAN Putative speedy protein E9 (sprot)


metabolite repair

A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites.


rRNA acetylation involved in maturation of SSU-rRNA

Any rRNA acetylation that is involved in maturation of SSU-rRNA.


Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.


ARH38_HUMAN Rho guanine nucleotide exchange factor 38 (sprot)

A Rho guanine nucleotide exchange factor 38 that is encoded in the genome of human.


Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O.


arginine catabolic process to proline via ornithine

The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine.


uracil binding

Binding to uracil.


D-ribose metabolic process

The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12.


oxytocin receptor activity

Combining with oxytocin to initiate a change in cell activity.


SPD16_HUMAN Putative speedy protein E16 (sprot)


germ-line stem cell division

The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.


glycolipid translocation

The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


SIRB2_HUMAN Signal-regulatory protein beta-2 (sprot)

A signal-regulatory protein beta-2 that is encoded in the genome of human.


Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O.


regulation of establishment of bipolar cell polarity

Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane.


termination of RNA polymerase III transcription

A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues.


phagolysosome assembly involved in apoptotic cell clearance

The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance.


bub1-bub3 complex

Protein complex that associates with the kinetochores.


alpha-amino acid metabolic process

The chemical reactions and pathways involving an alpha-amino acid.


double-strand break repair via single-strand annealing

Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.


butyrate catabolic process

The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid.


Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.


S4R3C0_HUMAN Immunoglobulin heavy variable 3/OR16-17 (non-functional) (Fragment) (trembl)


isopentenyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids.


gonadotropin-releasing hormone receptor binding

Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.


NADPH-adrenodoxin reductase activity

Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.


GTP cyclohydrolase binding

Binding to a GTP cyclohydrolase.


regulation of skeletal muscle cell proliferation

Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.


SNG4_HUMAN Synaptogyrin-4 (sprot)

A synaptogyrin-4 that is encoded in the genome of human.


AMERL_HUMAN AMMECR1-like protein (sprot)

An AMMECR1-like protein that is encoded in the genome of human.


dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.


slow-twitch skeletal muscle fiber contraction

A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.


KI2LA_HUMAN Killer cell immunoglobulin-like receptor 2DL5A (sprot)

A killer cell immunoglobulin-like receptor 2DL5A that is encoded in the genome of human.


GAL3A_HUMAN Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial (sprot)

A glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial that is encoded in the genome of human.


NAD(P)+ transhydrogenase activity

Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.


interleukin-9 receptor binding

Binding to an interleukin-9 receptor.


thyrotropin-releasing hormone activity

The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


spine apparatus assembly

The aggregation, arrangement and bonding together of a set of components to form a spine apparatus.


SPDE7_HUMAN Putative speedy protein E7 (sprot)


T178B_HUMAN Transmembrane protein 178B (sprot)

A transmembrane protein 178B that is encoded in the genome of human.


lipid kinase activity

Catalysis of the phosphorylation of a simple or complex lipid.


TEX26_HUMAN Testis-expressed protein 26 (sprot)

A testis-expressed protein 26 that is encoded in the genome of human.


CO040_HUMAN UPF0235 protein C15orf40 (sprot)

A UPF0235 protein C15orf40 that is encoded in the genome of human.


A0A191URJ7_HUMAN KIR2DL protein (trembl)


DNA strand elongation involved in mitotic DNA replication

Any DNA strand elongation involved in mitotic cell cycle DNA replication.


palmitoyl-CoA 9-desaturase activity

Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O.


protein methylesterase activity

Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol.


exopolyphosphatase activity

Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.


regulation of ERBB signaling pathway

Any process that modulates the frequency, rate or extent of ERBB signaling pathway.


regulation of glucosylceramidase activity

Any process that modulates the frequency, rate or extent of glucosylceramidase activity.


myosin II filament disassembly

The disassembly of a bipolar filament composed of myosin II molecules.


pyrimidine nucleoside transport

The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cytoskeletal rearrangement involved in phagocytosis, engulfment

The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.


AN34C_HUMAN Ankyrin repeat domain-containing protein 34C (sprot)

An ankyrin repeat domain-containing protein 34C that is encoded in the genome of human.


regulation of muscle system process

Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.


nuclear microtubule

Any microtubule in the nucleus of a cell.


GTP 3',8'-cyclase activity

Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.


double-stranded DNA endonuclease activity

Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks.


Sec62/Sec63 complex

A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.


lytic vacuole

A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.


SPD15_HUMAN Putative speedy protein E15 (sprot)


PAS complex

A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.


ribonuclease P complex

A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs.


calcium activated phospholipid scrambling

The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.


DNA recombinase auxiliary factor complex

A protein complex that binds to a recombinase and incrseases its activity.


adenine salvage

Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis.


cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity

Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP.


oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group.


CTP reductase activity

Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


TTP reductase activity

Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor

Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin.


UDP reductase activity

Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin.


ADP reductase activity

Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin.


CDP reductase activity

Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin.


Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.


DNA-(apurinic or apyrimidinic site) endonuclease, initiator methionine removed form (human)

A DNA-(apurinic or apyrimidinic site) endonuclease (human) that has had the initiator methionine removed. UniProtKB:P27695, 2-318.


eukaryotic translation initiation factor 4E phosphorylated 1 (human)

A eukaryotic translation initiation factor 4E (human) that has been phosphorylated on the residue at the position equivalent to Ser-53 of the amino acid sequence represented by UniProtKB:P06730-1. Example: UniProtKB:P06730-1, Ser-53, MOD:00046.


An Axin that is a translation product of the human AXIN1 gene or a 1:1 ortholog thereof.


Axin-1 isoform 1 (human)

An Axin-1 isoform 1 that is encoded in the genome of human.


Axin-1 ubiquitinated 1 (human)

An Axin-1 (human) that has been ubiquitinated on the residue at the position equivalent to Lys-501 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Lys-501, MOD:01148.


Axin-1 ADP-ribosylated form (human)

An Axin-1 (human) that includes at least one ADP-ribosylated residue. UniProtKB:O15169, MOD:00752.


Axin-1 isoform 2 (human)

An Axin-1 isoform 2 that is encoded in the genome of human.


Axin-1 phosphorylated 1 (human)

An Axin-1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-481, and phosphoserine at positions 486 and 493 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Thr-481, MOD:00047|Ser-486/Ser-493, MOD:00046.


Axin-1 ADP-ribosylated and ubiquitinated form (human)

An Axin-1 (human) that includes at least one ADP-ribosylated residue and at least one ubiquitinated lysine. UniProtKB:O15169, MOD:00752|MOD:01148.


zinc-alpha-2-glycoprotein N-glycosylated 33 (human)

A zinc-alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-128 of the amino acid sequence represented by UniProtKB:P25311-1, in which the glycan composition is represented by GlyTouCan:G60923RB. Example: UniProtKB:P25311-1, Asn-128, MOD:00160~GNO:G60923RB.


encapsulin nanocompartment

Intracellular non-membrane bound organelle, consisting of proteinaceous polyhedral shells that encapsulate enzymes, protecting the contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only one protein, and has only a few proteins inside. Shells about vary from about 25-42 nm in diameter. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla.


serine/threonine-protein kinase VRK2 isoform h4 (human)

A serine/threonine-protein kinase VRK2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86Y07-4.


prolargin O-glycosylated 6 (human)

A prolargin (human) that has been O-glycosylated at the residue equivalent to Thr-56 of the amino acid sequence represented by UniProtKB:P51888-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P51888-1, Thr-56, MOD:00005~GNO:G53434XO.


potassium voltage-gated channel subfamily H member 5 isoform 3 (human)

A voltage-gated potassium channel KCNH5 isoform 3 that is encoded in the genome of human.


Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2.


mucin-1 O-glycosylated 9 (human)

A mucin-1 (human) that has been O-glycosylated at the residue equivalent to Thr-919 of the amino acid sequence represented by UniProtKB:P15941-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P15941-1, Thr-919, MOD:00005~GNO:G58001LT.


ETS domain-containing transcription factor ERF isoform h2 (human)

An ETS domain-containing transcription factor ERF (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P50548-2.


heat shock 70 kDa protein 4 isoform h2 (human)

A heat shock 70 kDa protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34932-2.


HSPH protein

An Hsp70 family chaperone that has its ATP-binding and substrate-binding domains separated by a linker domain of over 100 amino acids. Proteins in this class function generally as nucleotide exchange factors for cytosolic Hsp70s.


heat shock protein 105 kDa isoform Beta (human)

A heat shock protein 105 kDa isoform 2 that is encoded in the genome of human.


heat shock protein 105 kDa isoform Alpha (human)

A heat shock protein 105 kDa isoform 1 that is encoded in the genome of human.


heat shock 70 kDa protein 4L

An HSPH protein that is a translation product of the human HSPA4L gene or a 1:1 ortholog thereof.


heat shock 70 kDa protein 4 isoform 1 (human)

A heat shock 70 kDa protein 4 isoform 1 that is encoded in the genome of human.


heat shock protein 105 kDa isoform h4 (human)

A heat shock protein 105 kDa (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-4.


heat shock protein 105 kDa isoform h3 (human)

A heat shock protein 105 kDa (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-3.


heat shock protein 105 kDa

An HSPH protein that is a translation product of the human HSPH1 gene or a 1:1 ortholog thereof.


heat shock 70 kDa protein 4

An HSPH protein that is a translation product of the human HSPA4 gene or a 1:1 ortholog thereof.


14-3-3 protein gamma isoform 1 (human)

A 14-3-3 protein gamma isoform 1 that is encoded in the genome of human.


Ral guanine nucleotide dissociation stimulator-like 3 isoform h1 (human)

A Ral guanine nucleotide dissociation stimulator-like 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3MIN7-1.


tRNA transmembrane transporter activity

Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other.


adiponectin O-glycosylated 1 (human)

An adiponectin (human) that has been O-glycosylated at the residue equivalent to Thr-21 of the amino acid sequence represented by UniProtKB:Q15848-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q15848-1, Thr-21, MOD:00005~GNO:G53434XO.


DnaJ homolog subfamily C member 12 isoform a (human)

A DnaJ homolog subfamily C member 12 isoform 1 that is encoded in the genome of human.


alpha-N-acetylgalactosaminidase N-glycosylated 30 (human)

An alpha-N-acetylgalactosaminidase (human) that has been N-glycosylated at the residue equivalent to Asn-177 of the amino acid sequence represented by UniProtKB:P17050-1, in which the glycan structure is represented by GlyTouCan:G45359RY. Example: UniProtKB:P17050-1, Asn-177, MOD:00160~GNO:G45359RY.


UDP-glucuronosyltransferase 2B15 N-glycosylated 1 (human)

A UDP-glucuronosyltransferase 2B15 (human) that has been N-glycosylated at the residue equivalent to Asn-316 of the amino acid sequence represented by UniProtKB:P54855-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P54855-1, Asn-316, MOD:00160~GNO:G06247RL.


BCAS3 microtubule associated cell migration factor isoform h4 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-8.


BCAS3 microtubule associated cell migration factor isoform h1 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-2.


BCAS3 microtubule associated cell migration factor isoform 2 (human)

A BCAS3 microtubule associated cell migration factor isoform 1 that is encoded in the genome of human.


BCAS3 microtubule associated cell migration factor isoform h5 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-7.


BCAS3 microtubule associated cell migration factor isoform h3 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-3.


BCAS3 microtubule associated cell migration factor isoform h6 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-6.


heat shock factor 2-binding protein isoform h2 (human)

A heat shock factor 2-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75031-2.


heat shock factor 2-binding protein isoform h1 (human)

A heat shock factor 2-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75031-1.


T-cell surface glycoprotein CD4 N-glycosylated 23 (human)

A T-cell surface glycoprotein CD4 (human) that has been N-glycosylated at the residue equivalent to Asn-296 of the amino acid sequence represented by UniProtKB:P01730-1, in which the glycan structure is represented by GlyTouCan:G65890UA. Example: UniProtKB:P01730-1, Asn-296, MOD:00160~GNO:G65890UA.


indole catabolic process

The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


indole biosynthetic process

The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


peptide chain release factor 1-like, mitochondrial isoform h3 (human)

A peptide chain release factor 1-like, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGC7-3.


specification of animal organ axis polarity

The process in which the polarity of an animal organ axis is specified.


ATP-binding cassette sub-family A member 9 isoform h3 (human)

An ATP-binding cassette sub-family A member 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUA7-3.


neogenin isoform h2 (human)

A neogenin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92859-2.


excitatory amino acid transporter 4 isoform h1 (human)

An excitatory amino acid transporter 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48664-1.


mating-type a-factor pheromone receptor activity

Combining with the mating-type a-factor pheromone to initiate a change in cell activity.


nuclear envelope integral membrane protein 2 isoform h1 (human)

A nuclear envelope integral membrane protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A6NFY4-1.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h2 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-2.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3 that is encoded in the genome of human.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h1 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-1.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h4 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-4.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase phosphorylated form (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that includes at least one phosphorylated residue. UniProtKB:Q99640, MOD:00696.


lymphoid-specific helicase isoform h3 (human)

A lymphoid-specific helicase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRZ9-3.


A cyclin-A that is a translation product of the human CCNA1 gene or a 1:1 ortholog thereof.


cyclin-A1 ubiquitinated form (human)

A cyclin-A1 (human) that includes at least one ubiquitinated lysine. UniProtKB:P78396, MOD:01148.


cyclin-A1 isoform h1 (human)

A cyclin-A1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78396-1.


cyclin-A1 isoform h2 (human)

A cyclin-A1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78396-2.


cyclin-A1 isoform 3 (human)

A cyclin-A1 isoform 3 that is encoded in the genome of human.


dynein regulatory complex subunit 2 isoform h2 (human)

A dynein regulatory complex subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IXS2-2.


dynein regulatory complex subunit 2 isoform h1 (human)

A dynein regulatory complex subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IXS2-1.


membrane-spanning 4-domains subfamily A member 13 isoform h3 (human)

A membrane-spanning 4-domains subfamily A member 13 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5J8X5-3.


hedgehog-interacting protein, signal peptide removed form (human)

A hedgehog-interacting protein (human) that has had the signal peptide removed. UniProtKB:Q96QV1, 18-700.


inactive ADP-ribosyltransferase ARH2 isoform h1 (human)

An inactive ADP-ribosyltransferase ARH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NDY3-1.


inactive ADP-ribosyltransferase ARH2

A protein that is a translation product of the human ADPRHL1 gene or a 1:1 ortholog thereof.


inactive ADP-ribosyltransferase ARH2 isoform h2 (human)

An inactive ADP-ribosyltransferase ARH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NDY3-2.


prostate-specific antigen N-glycosylated 5 (human)

A prostate-specific antigen (human) that has been N-glycosylated at the residue equivalent to Asn-69 of the amino acid sequence represented by UniProtKB:P07288-1, in which the glycan composition is represented by GlyTouCan:G03574QJ. Example: UniProtKB:P07288-1, Asn-69, MOD:00160~GNO:G03574QJ.


platelet-derived growth factor receptor-like protein isoform 1 (human)

A platelet-derived growth factor receptor-like protein isoform 1 that is encoded in the genome of human.


dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

A protein that is a translation product of the human RPN1 gene or a 1:1 ortholog thereof.


dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, signal peptide removed form (human)

A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (human) that has had the signal peptide removed. UniProtKB:P04843, 24-607.


Catalysis of the reaction: H+ + NADH + O2 + quinolin-4-ol = H2O + NAD+ + quinoline-3,4-diol.


PTB-containing, cubilin and LRP1-interacting protein isoform h3 (human)

A PTB-containing, cubilin and LRP1-interacting protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z2X4-3.


PTB-containing, cubilin and LRP1-interacting protein isoform 4 (human)

A PTB-containing, cubilin and LRP1-interacting protein isoform 4 that is encoded in the genome of human.


PTB-containing, cubilin and LRP1-interacting protein isoform h1 (human)

A PTB-containing, cubilin and LRP1-interacting protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z2X4-1.


PTB-containing, cubilin and LRP1-interacting protein isoform h2 (human)

A PTB-containing, cubilin and LRP1-interacting protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z2X4-2.


Ras-specific guanine nucleotide-releasing factor RalGPS2 isoform h3 (human)

A Ras-specific guanine nucleotide-releasing factor RalGPS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86X27-3.


POU domain, class 3, transcription factor 2 isoform hN-OCT 5A (human)

A POU domain, class 3, transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20265-2.


POU domain, class 3, transcription factor 2

A protein that is a translation product of the human POU3F2 gene or a 1:1 ortholog thereof.


POU domain, class 3, transcription factor 2 isoform hN-OCT 3 (human)

A POU domain, class 3, transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20265-1.


POU domain, class 3, transcription factor 2 isoform hN-OCT 5B (human)

A POU domain, class 3, transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20265-3.


testis-specific serine/threonine-protein kinase 3 isoform 1 (human)

A testis-specific serine/threonine-protein kinase 3 isoform 1 that is encoded in the genome of human.


N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity

Catalysis of the reaction: H2O + N(8)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2.


effector-mediated suppression of host pattern-triggered immunity signaling

A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants.


effector-mediated suppression of host innate immune response

A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


effector-mediated suppression of host pattern-triggered immunity

A process mediated by a molecule secreted by a symbiont that results in the suppression of the innate immune response of the host organism via recognition of a microbe-associated molecular pattern. The innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction.


A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.


negative regulation of proline import across plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of proline import into cell.


positive regulation of myofibroblast cell apoptotic process

Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process.


serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1 (human)

A serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1 that is encoded in the genome of human.


ADP-ribosylation factor GTPase-activating protein 1 isoform h2 (human)

An ADP-ribosylation factor GTPase-activating protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N6T3-2.


WD repeat-containing protein 89

A protein that is a translation product of the human WDR89 gene or a 1:1 ortholog thereof.


dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform h2 (human)

A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04844-2.


positive regulation of thyroid gland epithelial cell proliferation

Any process that activates or increases the frequency, rate or extent of thyroid gland epithelial cell proliferation.


positive regulation of epithelial cell proliferation involved in lung bud dilation

Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially.


positive regulation of acinar cell proliferation

Any process that activates or increases the frequency, rate or extent of acinar cell proliferation.


zinc finger FYVE domain-containing protein 9 isoform 2 (human)

A zinc finger FYVE domain-containing protein 9 isoform 2 that is encoded in the genome of human.


dynein regulatory complex subunit 2

A protein that is a translation product of the human CCDC65 gene or a 1:1 ortholog thereof.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform h1 (human)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75251-1.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

A protein that is a translation product of the human NDUFS7 gene or a 1:1 ortholog thereof.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, transit peptide removed form (human)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that has had the transit peptide removed. UniProtKB:O75251, 39-213.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform h2 (human)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75251-2.


mismatch repair endonuclease PMS2

A protein that is a translation product of the human PMS2 gene or a 1:1 ortholog thereof.


mismatch repair endonuclease PMS2 isoform h2 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-2.


mismatch repair endonuclease PMS2 isoform h3 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-3.


mismatch repair endonuclease PMS2 isoform h4 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-4.


mismatch repair endonuclease PMS2 isoform h1 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-1.


ceramide synthase 5 isoform h2 (human)

A ceramide synthase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N5B7-2.


structural constituent of ascospore wall

The action of a molecule that contributes to the structural integrity of an ascospore wall.


integrin beta-8 isoform h1 (human)

An integrin beta-8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26012-1.


histone H3.3, initiator methionine removed monomethylated 3 (human)

A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Arg-27 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-27, MOD:00414.


histone-lysine N-methyltransferase MECOM isoform 7 (human)

A histone-lysine N-methyltransferase MECOM isoform 7 that is encoded in the genome of human.


homeobox protein Hox-B1 isoform h1 (human)

A homeobox protein Hox-B1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14653-1.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h1 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-1.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h3 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-3.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h4 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-4.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h2 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-2.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h7 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-7.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h6 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-6.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h5 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-5.


coiled-coil domain-containing protein 107 isoform h2 (human)

A coiled-coil domain-containing protein 107 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WV48-2.


DnaJ homolog subfamily C member 8 isoform 1 (human)

A DnaJ homolog subfamily C member 8 isoform 1 that is encoded in the genome of human.


DnaJ homolog subfamily C member 8, initiator methionine removed form (human)

A DnaJ homolog subfamily C member 8 (human) that has had the initiator methionine removed. UniProtKB:O75937, 2-253.


soluble scavenger receptor cysteine-rich domain-containing protein SSC5D O-glycosylated 10 (human)

A soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (human) that has been O-glycosylated at the residue equivalent to Thr-1462 of the amino acid sequence represented by UniProtKB:A1L4H1-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:A1L4H1-1, Thr-1462, MOD:00005~GNO:G58001LT.


transmembrane protein 161B isoform h2 (human)

A transmembrane protein 161B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NDZ6-2.


FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h1 (human)

A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-1.


FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h2 (human)

A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-2.


FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h3 (human)

A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-3.


negative regulation of phosphatidylserine biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process.


regulation of phosphatidylserine biosynthetic process

Any process that modulates the frequency, rate or extent of phosphatidylserine biosynthetic process.


positive regulation of phosphatidylserine biosynthetic process

Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process.


keratin-associated protein 3-3

A protein that is a translation product of the human KRTAP3-3 gene or a 1:1 ortholog thereof.


peptide cross-linking via S-(2-aminovinyl)-D-cysteine

The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine.


slit homolog 3 protein isoform 1 (human)

A slit homolog 3 protein isoform 1 that is encoded in the genome of human.


putative E3 ubiquitin-protein ligase UNKL isoform h4 (human)

A putative E3 ubiquitin-protein ligase UNKL (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H9P5-4.


Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+.


tyrosine-protein kinase SYK isoform Long (human)

A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of human.


postsynaptic specialization of symmetric synapse, intracellular component

A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses.


kielin/chordin-like protein O-glycosylated 1 (human)

A kielin/chordin-like protein (human) that has been O-glycosylated at the residue equivalent to Thr-38 of the amino acid sequence represented by UniProtKB:Q6ZWJ8-3, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q6ZWJ8-3, Thr-38, MOD:00005~GNO:G53434XO.


kielin/chordin-like protein isoform h3 (human)

A kielin/chordin-like protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZWJ8-3.


kielin/chordin-like protein isoform h4 (human)

A kielin/chordin-like protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZWJ8-4.


kielin/chordin-like protein isoform h2 (human)

A kielin/chordin-like protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZWJ8-2.


kielin/chordin-like protein O-glycosylated 2 (human)

A kielin/chordin-like protein (human) that has been O-glycosylated at the residue equivalent to Thr-413 of the amino acid sequence represented by UniProtKB:Q6ZWJ8-3, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q6ZWJ8-3, Thr-413, MOD:00005~GNO:G43417UB.


actin-binding protein WASF1 isoform 1 (human)

An actin-binding protein WASF1 isoform 1 that is encoded in the genome of human.


7-methylguanosine catabolic process

The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA.


xanthosine catabolic process

The chemical reactions and pathways resulting in the breakdown of xanthosine.


guanosine catabolic process

The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution.


guanosine-containing compound catabolic process

The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines).