regulation of B cell cytokine production

Any process that modulates the frequency, rate, or extent of B cell cytokine production.


regulation of B cell apoptotic process

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that modulates the frequency, rate, or extent of B cell apoptotic process.


monocyte proliferation

The expansion of a monocyte population by cell division.


positive regulation of interleukin-17A production

Any process that activates or increases the frequency, rate or extent of interleukin-17A production.


P2R3A_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (sprot)

A serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha that is encoded in the genome of human.


An amidophosphoribosyltransferase that is encoded in the genome of human.


GFPT1_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (sprot)

A glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 that is encoded in the genome of human.


WIT1_HUMAN Putative Wilms tumor upstream neighbor 1 gene protein (sprot)

A Wilms tumor-associated protein that is encoded in the genome of human.


EXOS9_HUMAN Exosome complex component RRP45 (sprot)

An exosome complex component RRP45 that is encoded in the genome of human.


exonucleolytic catabolism of deadenylated mRNA

The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.


AOXA_HUMAN Aldehyde oxidase (sprot)

An aldehyde oxidase that is encoded in the genome of human.


PSME1_HUMAN Proteasome activator complex subunit 1 (sprot)

A proteasome activator complex subunit 1 that is encoded in the genome of human.


antigen processing and presentation of exogenous antigen

The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex.


SUH_HUMAN Recombining binding protein suppressor of hairless (sprot)

A recombining binding protein suppressor of hairless that is encoded in the genome of human.


regulation of generation of precursor metabolites and energy

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.


arterial endothelial cell fate commitment

The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell.


blood vessel lumenization

The process in which a developing blood vessel forms an endothelial lumen through which blood will flow.


blood vessel endothelial cell fate specification

The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.


positive regulation of ERBB signaling pathway

Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway.


positive regulation of ephrin receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of ephrin receptor signaling pathway.


MEF2C_HUMAN Myocyte-specific enhancer factor 2C (sprot)

A myocyte-specific enhancer factor 2C that is encoded in the genome of human.


sinoatrial valve morphogenesis

The process in which the structure of the sinoatrial valve is generated and organized.


muscle cell fate determination

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed.


cellular response to trichostatin A

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.


P5F1B_HUMAN Putative POU domain, class 5, transcription factor 1B (sprot)


TYRO3_HUMAN Tyrosine-protein kinase receptor TYRO3 (sprot)

A tyrosine-protein kinase receptor TYRO3 that is encoded in the genome of human.


CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit (sprot)

A voltage-dependent calcium channel gamma-1 subunit that is encoded in the genome of human.


MTG8_HUMAN Protein CBFA2T1 (sprot)

A protein CBFA2T1 that is encoded in the genome of human.


APLP2_HUMAN Amyloid beta precursor like protein 2 (sprot)

An amyloid beta precursor like protein 2 that is encoded in the genome of human.


NPT2A_HUMAN Sodium-dependent phosphate transport protein 2A (sprot)

A sodium-dependent phosphate transport protein 2A that is encoded in the genome of human.


indole metabolic process

The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


gentamycin metabolic process

The chemical reactions and pathways involving gentamycin.


arsenate ion transmembrane transport

The process in which arsenate is transported across a membrane.


positive regulation of phosphate transmembrane transport

Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport.


ST2A1_HUMAN Sulfotransferase 2A1 (sprot)

A sulfotransferase 2A1 that is encoded in the genome of human.


alcohol sulfotransferase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.


bile-salt sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.


GABPA_HUMAN GA-binding protein alpha chain (sprot)

A GA-binding protein alpha chain that is encoded in the genome of human.


GABP1_HUMAN GA-binding protein subunit beta-1 (sprot)

A GA-binding protein subunit beta-1 that is encoded in the genome of human.


RING1_HUMAN E3 ubiquitin-protein ligase RING1 (sprot)

An E3 ubiquitin-protein ligase RING1 that is encoded in the genome of human.


RAD51_HUMAN DNA repair protein RAD51 homolog 1 (sprot)

A DNA repair protein RAD51 homolog 1 that is encoded in the genome of human.


DNA strand exchange activity

Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.


TNFC_HUMAN Lymphotoxin-beta (sprot)

A lymphotoxin-beta that is encoded in the genome of human.


PAX8_HUMAN Paired box protein Pax-8 (sprot)

A paired box protein Pax-8 that is encoded in the genome of human.


regulation of thyroid-stimulating hormone secretion

Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion.


ZN33A_HUMAN Zinc finger protein 33A (sprot)

A zinc finger protein 33A that is encoded in the genome of human.


ZN33B_HUMAN Zinc finger protein 33B (sprot)

A zinc finger protein 33B that is encoded in the genome of human.


FMR1_HUMAN Fragile X messenger ribonucleoprotein 1 (sprot)

A fragile X messenger ribonucleoprotein 1 that is encoded in the genome of human.


negative regulation of miRNA-mediated gene silencing

A process that decreases the rate, frequency, or extent of gene silencing by a microRNA (miRNA).


positive regulation of intracellular transport of viral material

Any process that activates or increases the frequency, rate or extent of intracellular transport of viral material.


negative regulation of mRNA catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process.


negative regulation of cytoplasmic translation

Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation.


FMOD_HUMAN Fibromodulin (sprot)

A fibromodulin that is encoded in the genome of human.


PRDX1_HUMAN Peroxiredoxin-1 (sprot)

A peroxiredoxin-1 that is encoded in the genome of human.


EGR3_HUMAN Early growth response protein 3 (sprot)

An early growth response protein 3 that is encoded in the genome of human.


SOX4_HUMAN Transcription factor SOX-4 (sprot)

A transcription factor SOX-4 that is encoded in the genome of human.


positive regulation of N-terminal peptidyl-lysine acetylation

Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation.


ACHD_HUMAN Acetylcholine receptor subunit delta (sprot)

An acetylcholine receptor subunit delta that is encoded in the genome of human.


CDK18_HUMAN Cyclin-dependent kinase 18 (sprot)

A cyclin-dependent kinase 18 that is encoded in the genome of human.


TNR9_HUMAN Tumor necrosis factor receptor superfamily member 9 (sprot)

A tumor necrosis factor receptor superfamily member 9 that is encoded in the genome of human.


regulation of immature T cell proliferation in thymus

Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus.


RL18_HUMAN Large ribosomal subunit protein eL18 (sprot)

A 60S ribosomal protein L18 that is encoded in the genome of human.


C1QBP_HUMAN Complement component 1 Q subcomponent-binding protein, mitochondrial (sprot)

A complement component 1 Q subcomponent-binding protein, mitochondrial that is encoded in the genome of human.


kininogen binding

Binding to a kininogen, a kinin precursor.


adrenergic receptor binding

Binding to an adrenergic receptor.


negative regulation of RIG-I signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the RIG-I signaling pathway.


CKAP4_HUMAN Cytoskeleton-associated protein 4 (sprot)

A cytoskeleton-associated protein 4 that is encoded in the genome of human.


AMPE_HUMAN Glutamyl aminopeptidase (sprot)

A glutamyl aminopeptidase that is encoded in the genome of human.


COGA1_HUMAN Collagen alpha-1(XVI) chain (sprot)

A collagen alpha-1(XVI) chain that is encoded in the genome of human.


collagen type XVI trimer

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A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils.


CD69_HUMAN Early activation antigen CD69 (sprot)

A CD69 molecule that is encoded in the genome of human.


ZO1_HUMAN Tight junction protein ZO-1 (sprot)

A tight junction protein ZO-1 that is encoded in the genome of human.


adherens junction maintenance

The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.


positive regulation of blood-brain barrier permeability

Any process that increases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain.


TRHY_HUMAN Trichohyalin (sprot)

A trichohyalin that is encoded in the genome of human.


CXCL9_HUMAN C-X-C motif chemokine 9 (sprot)

A C-X-C motif chemokine 9 that is encoded in the genome of human.


PIGF_HUMAN Phosphatidylinositol-glycan biosynthesis class F protein (sprot)

A phosphatidylinositol-glycan biosynthesis class F protein that is encoded in the genome of human.


ethanolaminephosphotransferase activity

Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.


PDE4B_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4B (sprot)

A cAMP-specific 3',5'-cyclic phosphodiesterase 4B that is encoded in the genome of human.


negative regulation of relaxation of cardiac muscle

Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle.


TISB_HUMAN mRNA decay activator protein ZFP36L1 (sprot)

An mRNA decay activator protein ZFP36L1 that is encoded in the genome of human.


NKG2E_HUMAN NKG2-E type II integral membrane protein (sprot)

An NKG2-E type II integral membrane protein that is encoded in the genome of human.


DERM_HUMAN Dermatopontin (sprot)

A dermatopontin that is encoded in the genome of human.


BSPH1_HUMAN Binder of sperm protein homolog 1 (sprot)

A binder of sperm protein homolog 1 that is encoded in the genome of human.


SPAG1_HUMAN Sperm-associated antigen 1 (sprot)

A sperm-associated antigen 1 that is encoded in the genome of human.


axonemal dynein complex assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.


KRA11_HUMAN Keratin-associated protein 1-1 (sprot)

A keratin-associated protein 1-1 that is encoded in the genome of human.


TFF3_HUMAN Trefoil factor 3 (sprot)

A trefoil factor 3 that is encoded in the genome of human.


KHDR1_HUMAN KH domain-containing, RNA-binding, signal transduction-associated protein 1 (sprot)

A KH domain-containing, RNA-binding, signal transduction-associated protein 1 that is encoded in the genome of human.


regulation of RNA export from nucleus

Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm.


Grb2-Sos complex

A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.


DLX2_HUMAN Homeobox protein DLX-2 (sprot)

A homeobox protein DLX-2 that is encoded in the genome of human.


SCN1B_HUMAN Sodium channel subunit beta-1 (sprot)

A sodium channel subunit beta-1 that is encoded in the genome of human.


voltage-gated sodium channel activity involved in Purkinje myocyte action potential

Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


corticospinal neuron axon guidance

The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues.


membrane depolarization during Purkinje myocyte cell action potential

The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


positive regulation of voltage-gated sodium channel activity

Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity.


BAX_HUMAN Apoptosis regulator BAX (sprot)

An apoptosis regulator BAX that is encoded in the genome of human.


T cell homeostatic proliferation

The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.


B cell negative selection

Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.


release of matrix enzymes from mitochondria

The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process.


positive regulation of developmental pigmentation

Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.


B cell receptor apoptotic signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell.


positive regulation of motor neuron apoptotic process

Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process.


BAX complex

An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators.


BAK complex

An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators.


B2CL1_HUMAN Bcl-2-like protein 1 (sprot)

A Bcl-2-like protein 1 that is encoded in the genome of human.


dendritic cell proliferation

The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.


apoptotic process in bone marrow cell

The apoptotic process in cells in the bone marrow.


MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (sprot)

An induced myeloid leukemia cell differentiation protein Mcl-1 that is encoded in the genome of human.


positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway.


SLC31_HUMAN Amino acid transporter heavy chain SLC3A1 (sprot)

A neutral and basic amino acid transport protein rBAT that is encoded in the genome of human.


basic amino acid transport

The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (sprot)

A DNA polymerase epsilon catalytic subunit A that is encoded in the genome of human.


KLC1_HUMAN Kinesin light chain 1 (sprot)

A kinesin light chain 1 that is encoded in the genome of human.


PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (sprot)

A peroxisome proliferator-activated receptor alpha that is encoded in the genome of human.


positive regulation of transformation of host cell by virus

Any process that activates or increases the frequency, rate or extent of transformation of host cell by virus.


regulation of cellular ketone metabolic process

Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.


regulation of fatty acid transport

Any process that modulates the frequency, rate or extent of fatty acid transport.


SOS1_HUMAN Son of sevenless homolog 1 (sprot)

A son of sevenless homolog 1 that is encoded in the genome of human.


regulation of pro-B cell differentiation

Any process that modulates the frequency, rate or extent of pro-B cell differentiation.


SOS2_HUMAN Son of sevenless homolog 2 (sprot)

A son of sevenless homolog 2 that is encoded in the genome of human.


ACK1_HUMAN Activated CDC42 kinase 1 (sprot)

An activated CDC42 kinase 1 that is encoded in the genome of human.


LRP1_HUMAN Prolow-density lipoprotein receptor-related protein 1 (sprot)

A low-density lipoprotein receptor-related protein 1 that is encoded in the genome of human.


alpha-2 macroglobulin receptor activity

Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis.


apolipoprotein receptor activity

Combining with an apolipoprotein to initiate a change in cell activity.


regulation of phospholipase A2 activity

Any process that modulates the activity of the enzyme phospholipase A2.


SRSF1_HUMAN Serine/arginine-rich splicing factor 1 (sprot)

A splicing factor, arginine/serine-rich 1 that is encoded in the genome of human.


RHG01_HUMAN Rho GTPase-activating protein 1 (sprot)

A Rho GTPase-activating protein 1 that is encoded in the genome of human.


negative regulation of endocytic recycling

Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling.


CP24A_HUMAN 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (sprot)

A 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial that is encoded in the genome of human.


Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol.


1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity

Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol).


Catalysis of the reaction: calcidiol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin].


vitamin D 25-hydroxylase activity

Catalysis of the hydroxylation of C-25 of any form of vitamin D.


ACTN3_HUMAN Alpha-actinin-3 (sprot)

An alpha-actinin-3 that is encoded in the genome of human.


negative regulation of relaxation of muscle

Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle.


positive regulation of glucose catabolic process to lactate via pyruvate

Any process that activates or increases the frequency, rate or extent of glucose catabolic process to lactate via pyruvate.


FOXM1_HUMAN Forkhead box protein M1 (sprot)

A forkhead box protein M1 that is encoded in the genome of human.


RGS1_HUMAN Regulator of G-protein signaling 1 (sprot)

A regulator of G-protein signaling 1 that is encoded in the genome of human.


leukotriene signaling pathway

A G protein-coupled receptor signaling pathway initiated by leukotriene binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


TLE5_HUMAN TLE family member 5 (sprot)

A TLE family member 5 that is encoded in the genome of human.


SRSF4_HUMAN Serine/arginine-rich splicing factor 4 (sprot)

A serine/arginine-rich splicing factor 4 that is encoded in the genome of human.


PCDH1_HUMAN Protocadherin-1 (sprot)

A protocadherin-1 that is encoded in the genome of human.


TGM3_HUMAN Protein-glutamine gamma-glutamyltransferase E (sprot)

A protein-glutamine gamma-glutamyltransferase E that is encoded in the genome of human.


PP2BA_HUMAN Protein phosphatase 3 catalytic subunit alpha (sprot)

A protein phosphatase 3 catalytic subunit alpha that is encoded in the genome of human.


regulation of cell proliferation involved in kidney morphogenesis

Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney.


positive regulation of glomerulus development

Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


negative regulation of angiotensin-activated signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway.


positive regulation of cardiac muscle hypertrophy in response to stress

Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress.


DHX9_HUMAN ATP-dependent RNA helicase A (sprot)

An ATP-dependent RNA helicase A that is encoded in the genome of human.


regulatory region RNA binding

Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.


3'-5' DNA/RNA helicase activity

Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis.


triplex DNA binding

Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination.


RISC complex binding

Binding to a RISC complex.


single-stranded 3'-5' DNA helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'.


DNA-templated viral transcription

A transcription process that uses a viral DNA as a template.


positive regulation of viral transcription

Any process that activates or increases the frequency, rate or extent of viral transcription.


positive regulation of polysome binding

Any process that activates or increases the frequency, rate or extent of polysome binding.


regulation of cytoplasmic translation

Any process that modulates the frequency, rate or extent of cytoplasmic translation.


QOR_HUMAN Quinone oxidoreductase (sprot)

A quinone oxidoreductase that is encoded in the genome of human.


NADH binding

Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.


CACB2_HUMAN Voltage-dependent L-type calcium channel subunit beta-2 (sprot)

A voltage-dependent L-type calcium channel subunit beta-2 that is encoded in the genome of human.


membrane depolarization during atrial cardiac muscle cell action potential

The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


I10R2_HUMAN Interleukin-10 receptor subunit beta (sprot)

An interleukin-10 receptor subunit beta that is encoded in the genome of human.


interleukin-10 receptor activity

Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


interleukin-28 receptor complex

A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1).


DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (sprot)

A discoidin domain-containing receptor 1 that is encoded in the genome of human.


protein tyrosine kinase collagen receptor activity

Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.


S20A2_HUMAN Sodium-dependent phosphate transporter 2 (sprot)

A sodium-dependent phosphate transporter 2 that is encoded in the genome of human.


GOGA3_HUMAN Golgin subfamily A member 3 (sprot)

A golgin subfamily A member 3 that is encoded in the genome of human.


GOGA2_HUMAN Golgin subfamily A member 2 (sprot)

A golgin subfamily A member 2 that is encoded in the genome of human.


meiotic spindle assembly

The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis.


Golgi cis cisterna

The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.


LG3BP_HUMAN Galectin-3-binding protein (sprot)

A galectin-3-binding protein that is encoded in the genome of human.


LOXL1_HUMAN Lysyl oxidase homolog 1 (sprot)

A lysyl oxidase homolog 1 that is encoded in the genome of human.


ECHP_HUMAN Peroxisomal bifunctional enzyme (sprot)

A peroxisomal bifunctional enzyme that is encoded in the genome of human.


Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.


MFGM_HUMAN Lactadherin (sprot)

A lactadherin that is encoded in the genome of human.


ADCY2_HUMAN Adenylate cyclase type 2 (sprot)

An adenylate cyclase type 2 that is encoded in the genome of human.


CP4F3_HUMAN Cytochrome P450 4F3 (sprot)

A cytochrome P450 4F3 that is encoded in the genome of human.


PDE4C_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4C (sprot)

A cAMP-specific 3',5'-cyclic phosphodiesterase 4C that is encoded in the genome of human.


DEMA_HUMAN Dematin (sprot)

A dematin that is encoded in the genome of human.


PDE4D_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4D (sprot)

A cAMP-specific 3',5'-cyclic phosphodiesterase 4D that is encoded in the genome of human.


signaling receptor regulator activity

Binds to and modulates the activity of a receptor.


DSC1_HUMAN Desmocollin-1 (sprot)

A desmocollin-1 that is encoded in the genome of human.


A pseudouridine-5'-phosphatase that is encoded in the genome of human.


pseudouridine 5'-phosphatase activity

Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate.


TICN1_HUMAN Testican-1 (sprot)

A testican-1 that is encoded in the genome of human.


SG11B_HUMAN Sperm-associated antigen 11B (sprot)

A sperm-associated antigen 11B that is encoded in the genome of human.


CLM6_HUMAN CMRF35-like molecule 6 (sprot)

A CMRF35-like molecule 6 that is encoded in the genome of human.


CD47_HUMAN Leukocyte surface antigen CD47 (sprot)

A CD47 molecule that is encoded in the genome of human.


PPID_HUMAN Peptidyl-prolyl cis-trans isomerase D (sprot)

A eukaryotic-type peptidyl-prolyl cis-trans isomerase D that is encoded in the genome of human.


ADCY1_HUMAN Adenylate cyclase type 1 (sprot)

An adenylate cyclase type 1 that is encoded in the genome of human.


FGL1_HUMAN Fibrinogen-like protein 1 (sprot)

A fibrinogen-like protein 1 that is encoded in the genome of human.


ITK_HUMAN Tyrosine-protein kinase ITK/TSK (sprot)

A tyrosine-protein kinase ITK/TSK that is encoded in the genome of human.


SSRP1_HUMAN FACT complex subunit SSRP1 (sprot)

A FACT complex subunit SSRP1 that is encoded in the genome of human.


FACT complex

A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage.


RBL2_HUMAN Retinoblastoma-like protein 2 (sprot)

A retinoblastoma-like protein 2 that is encoded in the genome of human.


CAMP2_HUMAN Calmodulin-regulated spectrin-associated protein 2 (sprot)

A calmodulin-regulated spectrin-associated protein 1-like protein 1 that is encoded in the genome of human.


regulation of organelle organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.


regulation of Golgi organization

Any process that modulates the frequency, rate or extent of Golgi organization.


SPIR1_HUMAN Protein spire homolog 1 (sprot)

A protein spire homolog 1 that is encoded in the genome of human.


formin-nucleated actin cable assembly

The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


SLFN5_HUMAN Schlafen family member 5 (sprot)

A Schlafen family member 5 that is encoded in the genome of human.


GOG8F_HUMAN Putative golgin subfamily A member 8F/8G (sprot)


ZN844_HUMAN Zinc finger protein 844 (sprot)

A zinc finger protein 844 that is encoded in the genome of human.


MZT1_HUMAN Mitotic-spindle organizing protein 1 (sprot)

A mitotic-spindle organizing protein 1 that is encoded in the genome of human.


gamma-tubulin complex localization

Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location.


ACSM1_HUMAN Acyl-coenzyme A synthetase ACSM1, mitochondrial (sprot)

An acyl-coenzyme A synthetase ACSM1, mitochondrial that is encoded in the genome of human.


CoA-ligase activity

Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.


benzoate-CoA ligase activity

Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.


benzoate metabolic process

The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid.


butyrate metabolic process

The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid.


ACS2A_HUMAN Acyl-coenzyme A synthetase ACSM2A, mitochondrial (sprot)

An acyl-coenzyme A synthetase ACSM2A, mitochondrial that is encoded in the genome of human.


S38AB_HUMAN Putative sodium-coupled neutral amino acid transporter 11 (sprot)

A putative sodium-coupled neutral amino acid transporter 11 that is encoded in the genome of human.


VAC14_HUMAN Protein VAC14 homolog (sprot)

A protein VAC14 that is encoded in the genome of human.


ZN616_HUMAN Zinc finger protein 616 (sprot)

A zinc finger protein 616 that is encoded in the genome of human.


F27E3_HUMAN Protein FAM27E3 (sprot)

A protein FAM27E3 that is encoded in the genome of human.


ZN543_HUMAN Zinc finger protein 543 (sprot)

A zinc finger protein 543 that is encoded in the genome of human.


SIG14_HUMAN Sialic acid-binding Ig-like lectin 14 (sprot)

A sialic acid-binding Ig-like lectin 14 that is encoded in the genome of human.


NSUN2_HUMAN RNA cytosine C(5)-methyltransferase NSUN2 (sprot)

An RNA cytosine C(5)-methyltransferase NSUN2 that is encoded in the genome of human.


Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine.


meiotic cell cycle checkpoint signaling

A signaling process that contributes to a meiotic cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage.


mRNA methylation

The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.


DMPK_HUMAN Myotonin-protein kinase (sprot)

A myotonin-protein kinase that is encoded in the genome of human.


myosin phosphatase regulator activity

Binds to and modulates of the activity of myosin phosphatase.


muscle cell apoptotic process

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle.


regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction

Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


DMWD_HUMAN Dystrophia myotonica WD repeat-containing protein (sprot)

A dystrophia myotonica WD repeat-containing protein that is encoded in the genome of human.


RBBP4_HUMAN Histone-binding protein RBBP4 (sprot)

A histone-binding protein RBBP4 that is encoded in the genome of human.


CAF-1 complex

A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.


NCBP1_HUMAN Nuclear cap-binding protein subunit 1 (sprot)

A nuclear cap-binding protein subunit 1 that is encoded in the genome of human.


positive regulation of RNA binding

Any process that activates or increases the frequency, rate or extent of RNA binding.


MGAT3_HUMAN Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (sprot)

A beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R.


MGT5A_HUMAN Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (sprot)

An alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A that is encoded in the genome of human.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors.


ABCC8_HUMAN ATP-binding cassette sub-family C member 8 (sprot)

An ATP-binding cassette sub-family C member 8 that is encoded in the genome of human.


negative regulation of neuroblast migration

Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.


positive regulation of uterine smooth muscle relaxation

Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation.


KCNA1_HUMAN Potassium voltage-gated channel subfamily A member 1 (sprot)

A voltage-gated potassium channel subunit KCNA1 that is encoded in the genome of human.


neuronal signal transduction

The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular.


detection of mechanical stimulus involved in sensory perception of touch

The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal.


EP300_HUMAN Histone acetyltransferase p300 (sprot)

A histone acetyltransferase p300 that is encoded in the genome of human.


lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.


peptide N-acetyltransferase activity

Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.


Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide.


protein propionyltransferase activity

Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide.


Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide.


histone lactyltransferase activity

Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[histone].


peptide butyryltransferase activity

Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide.


histone crotonyltransferase activity

Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone.


histone butyryltransferase activity

Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone.


histone H3K122 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122).


thigmotaxis

The directed movement of an animal in response to touch.


behavioral defense response

A behavioral response seeking to protect an organism from an a perceived external threat to that organism.


N-terminal peptidyl-lysine acetylation

The acetylation of the N-terminal lysine of proteins.


swimming

Self-propelled movement of an organism from one location to another through water, often by means of active fin movement.


peptidyl-lysine propionylation

The propionylation of peptidyl-lysine.


peptidyl-lysine crotonylation

The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid.


peptidyl-lysine butyrylation

The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid.


AHNK_HUMAN Neuroblast differentiation-associated protein AHNAK (sprot)

A neuroblast differentiation-associated protein AHNAK that is encoded in the genome of human.


structural molecule activity conferring elasticity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling.


ZN415_HUMAN Zinc finger protein 415 (sprot)

A zinc finger protein 415 that is encoded in the genome of human.


R51A2_HUMAN RAD51-associated protein 2 (sprot)

A RAD51-associated protein 2 that is encoded in the genome of human.


GOG8D_HUMAN Putative golgin subfamily A member 8D (sprot)


IFFO1_HUMAN Non-homologous end joining factor IFFO1 (sprot)

A non-homologous end joining factor IFFO1 that is encoded in the genome of human.


ZN763_HUMAN Zinc finger protein 763 (sprot)

A zinc finger protein 763 that is encoded in the genome of human.


NIPA4_HUMAN Magnesium transporter NIPA4 (sprot)

A magnesium transporter NIPA4 that is encoded in the genome of human.


magnesium ion transmembrane transporter activity

Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.


magnesium ion transmembrane transport

The directed movement of magnesium ion across a membrane.


RIPP1_HUMAN Protein ripply1 (sprot)

A protein ripply1 that is encoded in the genome of human.


EGFEM_HUMAN Putative EGF-like and EMI domain-containing protein 1 (sprot)


NTCP7_HUMAN Sodium/bile acid cotransporter 7 (sprot)

A sodium/bile acid cotransporter 7 that is encoded in the genome of human.


TBC8B_HUMAN TBC1 domain family member 8B (sprot)

A TBC1 domain family member 8B that is encoded in the genome of human.


FCHO2_HUMAN F-BAR domain only protein 2 (sprot)

An F-BAR domain only protein 2 that is encoded in the genome of human.


ARL16_HUMAN ADP-ribosylation factor-like protein 16 (sprot)

An ADP-ribosylation factor-like protein 16 that is encoded in the genome of human.


CQ067_HUMAN Uncharacterized protein C17orf67 (sprot)

An uncharacterized protein C17orf67 that is encoded in the genome of human.


ABD18_HUMAN Protein ABHD18 (sprot)

A protein ABHD18 that is encoded in the genome of human.


SPEM2_HUMAN Uncharacterized protein SPEM2 (sprot)

An uncharacterized protein SPEM2 that is encoded in the genome of human.


DIK1C_HUMAN Divergent protein kinase domain 1C (sprot)

A divergent protein kinase domain 1C that is encoded in the genome of human.


CCD15_HUMAN Coiled-coil domain-containing protein 15 (sprot)

A coiled-coil domain-containing protein 15 that is encoded in the genome of human.


TMM62_HUMAN Transmembrane protein 62 (sprot)

A transmembrane protein 62 that is encoded in the genome of human.


ELP6_HUMAN Elongator complex protein 6 (sprot)

An elongator complex protein 6 that is encoded in the genome of human.


PLCX2_HUMAN PI-PLC X domain-containing protein 2 (sprot)

A PI-PLC X domain-containing protein 2 that is encoded in the genome of human.


SYCN_HUMAN Syncollin (sprot)

A syncollin that is encoded in the genome of human.


LMOD3_HUMAN Leiomodin-3 (sprot)

A leiomodin-3 that is encoded in the genome of human.


RGF1B_HUMAN Ras-GEF domain-containing family member 1B (sprot)

A Ras-GEF domain-containing family member 1B that is encoded in the genome of human.


SMAGP_HUMAN Small cell adhesion glycoprotein (sprot)

A small transmembrane and glycosylated protein that is encoded in the genome of human.


APOBR_HUMAN Apolipoprotein B receptor (sprot)

An apolipoprotein B receptor that is encoded in the genome of human.


INCA1_HUMAN Protein INCA1 (sprot)

A protein INCA1 that is encoded in the genome of human.


BRME1_HUMAN Break repair meiotic recombinase recruitment factor 1 (sprot)

A break repair meiotic recombinase recruitment factor 1 that is encoded in the genome of human.


DYH14_HUMAN Dynein axonemal heavy chain 14 (sprot)

A dynein axonemal heavy chain 14 that is encoded in the genome of human.


ADIG_HUMAN Adipogenin (sprot)

An adipogenin that is encoded in the genome of human.


HSP7E_HUMAN Heat shock 70 kDa protein 14 (sprot)

A heat shock 70 kDa protein 14 that is encoded in the genome of human.


'de novo' cotranslational protein folding

The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.


SCRN3_HUMAN Secernin-3 (sprot)

A secernin-3 that is encoded in the genome of human.


cysteine-type exopeptidase activity

Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


TM267_HUMAN Transmembrane protein 267 (sprot)

A transmembrane protein 267 that is encoded in the genome of human.


CGNL1_HUMAN Cingulin-like protein 1 (sprot)

A cingulin-like protein 1 that is encoded in the genome of human.


CF210_HUMAN Cilia- and flagella- associated protein 210 (sprot)

A cilia- and flagella- associated protein 210 that is encoded in the genome of human.


FP100_HUMAN Fanconi anemia core complex-associated protein 100 (sprot)

A Fanconi anemia core complex-associated protein 100 that is encoded in the genome of human.


YC023_HUMAN Putative uncharacterized protein LOC152225 (sprot)


MESP2_HUMAN Mesoderm posterior protein 2 (sprot)

A mesoderm posterior protein 2 that is encoded in the genome of human.


ZN816_HUMAN Zinc finger protein 816 (sprot)

A zinc finger protein 816 that is encoded in the genome of human.


LTOR4_HUMAN Ragulator complex protein LAMTOR4 (sprot)

A ragulator complex protein LAMTOR4 that is encoded in the genome of human.


U17LO_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (sprot)

A ubiquitin carboxyl-terminal hydrolase 17-like protein 24 that is encoded in the genome of human.


protein deubiquitination involved in ubiquitin-dependent protein catabolic process

The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism.


FABP9_HUMAN Fatty acid-binding protein 9 (sprot)

A fatty acid-binding protein 9 that is encoded in the genome of human.


NEXN_HUMAN Nexilin (sprot)

A nexilin that is encoded in the genome of human.


PJVK_HUMAN Pejvakin (sprot)

A pejvakin that is encoded in the genome of human.


programmed cell death in response to reactive oxygen species

Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.


stereocilium base

The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium.


MGAT2_HUMAN Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (sprot)

An alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R.


GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 2 that is encoded in the genome of human.


Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.


protein O-linked glycosylation via serine

The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine.


protein O-linked glycosylation via threonine

The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine.


GALT1_HUMAN Polypeptide N-acetylgalactosaminyltransferase 1 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 1 that is encoded in the genome of human.


AP1B1_HUMAN AP-1 complex subunit beta-1 (sprot)

An AP-1 complex subunit beta-1 that is encoded in the genome of human.


CPSF1_HUMAN Cleavage and polyadenylation specificity factor subunit 1 (sprot)

A cleavage and polyadenylation specificity factor subunit 1 that is encoded in the genome of human.


co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway

Any process involved in transcription termination-coupled  3' processing of RNA polymerase II RNA transcripts by 3' end cleavage  and addition of a poly(A) tail. This pathway is required for the maturation of primary protein-encoding transcripts into functional RNAs that can be exported from the nucleus and translated in the cytoplasm, but is also required for polyadenylation-dependent decay.


MN1_HUMAN Transcriptional activator MN1 (sprot)

A transcriptional activator MN1 that is encoded in the genome of human.


DBP_HUMAN D site-binding protein (sprot)

A D site-binding protein that is encoded in the genome of human.


TEF_HUMAN Thyrotroph embryonic factor (sprot)

A thyrotroph embryonic factor that is encoded in the genome of human.


BST1_HUMAN ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (sprot)

An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 that is encoded in the genome of human.


ADP-ribosyl cyclase activity

Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide.


cyclic ADP-ribose hydrolase

Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR).


regulation of cellular extravasation

Any process that modulates the frequency, rate, or extent of cellular extravasation.


regulation of superoxide metabolic process

Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.


BST2_HUMAN Bone marrow stromal antigen 2 (sprot)

A bone marrow stromal antigen 2 that is encoded in the genome of human.


negative regulation of plasmacytoid dendritic cell cytokine production

Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.


negative regulation of intracellular transport of viral material

Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material.


MPPA_HUMAN Mitochondrial-processing peptidase subunit alpha (sprot)

A mitochondrial-processing peptidase subunit alpha that is encoded in the genome of human.


KRIP1_HUMAN Putative protein KRIP1 (sprot)

A putative protein KRIP1 that is encoded in the genome of human.


FUT2_HUMAN Galactoside alpha-(1,2)-fucosyltransferase 2 (sprot)

A galactoside alpha-(1,2)-fucosyltransferase 2 that is encoded in the genome of human.


glycolipid metabolic process

The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent.


FUT5_HUMAN 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (sprot)

A 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 that is encoded in the genome of human.


FUT7_HUMAN Alpha-(1,3)-fucosyltransferase 7 (sprot)

An alpha-(1,3)-fucosyltransferase 7 that is encoded in the genome of human.


regulation of type IV hypersensitivity

Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response.


regulation of cell adhesion molecule production

Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.


regulation of leukocyte tethering or rolling

Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling.


regulation of neutrophil extravasation

Any process that modulates the frequency, rate or extent of neutrophil extravasation.


SIA4A_HUMAN CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (sprot)

A CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 that is encoded in the genome of human.


beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.


Catalysis of the reaction: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+).


memory B cell differentiation

The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody.


protein sialylation

A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein.


Golgi medial cisterna membrane

The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex.


Golgi trans cisterna membrane

The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex.


SIAT6_HUMAN CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (sprot)

A CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase that is encoded in the genome of human.


Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein + H+.


SIA4C_HUMAN CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (sprot)

A CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 that is encoded in the genome of human.


KIF1A_HUMAN Kinesin-like protein KIF1A (sprot)

A kinesin-like protein KIF1A that is encoded in the genome of human.


SCRN1_HUMAN Secernin-1 (sprot)

A secernin-1 that is encoded in the genome of human.


HMGX3_HUMAN HMG domain-containing protein 3 (sprot)

An HMG domain-containing protein 3 that is encoded in the genome of human.


TMM94_HUMAN Transmembrane protein 94 (sprot)

A transmembrane protein 94 that is encoded in the genome of human.


WASC5_HUMAN WASH complex subunit 5 (sprot)

A WASH complex subunit 5 that is encoded in the genome of human.


NU160_HUMAN Nuclear pore complex protein Nup160 (sprot)

A nuclear pore complex protein Nup160 that is encoded in the genome of human.


SCAP_HUMAN Sterol regulatory element-binding protein cleavage-activating protein (sprot)

A sterol regulatory element-binding protein cleavage-activating protein that is encoded in the genome of human.


sterol binding

Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.


SRBP2_HUMAN Sterol regulatory element-binding protein 2 (sprot)

A sterol regulatory element-binding protein 2 that is encoded in the genome of human.


C-8 sterol isomerase activity

Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols.


ARHG5_HUMAN Rho guanine nucleotide exchange factor 5 (sprot)

A Rho guanine nucleotide exchange factor 5 that is encoded in the genome of human.


positive regulation of protein import

Any process that activates or increases the frequency, rate or extent of protein import.


FOXO1_HUMAN Forkhead box protein O1 (sprot)

A forkhead box protein O1 that is encoded in the genome of human.


TBL3_HUMAN Transducin beta-like protein 3 (sprot)

A transducin beta-like protein 3 that is encoded in the genome of human.


TF3C1_HUMAN General transcription factor 3C polypeptide 1 (sprot)

A general transcription factor 3C polypeptide 1 that is encoded in the genome of human.


tRNA transcription

The synthesis of transfer RNA (tRNA) from a DNA template.


5S class rRNA transcription by RNA polymerase III

The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter.


tRNA transcription by RNA polymerase III

The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter.


transcription factor TFIIIC complex

A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.


KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (sprot)

A calcium-activated potassium channel subunit alpha-1 that is encoded in the genome of human.


large conductance calcium-activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


TWF1_HUMAN Twinfilin-1 (sprot)

A twinfilin-1 that is encoded in the genome of human.


regulation of actin phosphorylation

Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.


HYAL1_HUMAN Hyaluronidase-1 (sprot)

A hyaluronidase-1 that is encoded in the genome of human.


chondroitin hydrolase activity

Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-].


PNRC1_HUMAN Proline-rich nuclear receptor coactivator 1 (sprot)

A proline-rich nuclear receptor coactivator 1 that is encoded in the genome of human.


ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (sprot)

An aspartyl/asparaginyl beta-hydroxylase that is encoded in the genome of human.


peptidyl-aspartic acid 3-dioxygenase activity

Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2.


regulation of protein depolymerization

Any process that modulates the frequency, rate or extent of protein depolymerization.


CETN1_HUMAN Centrin-1 (sprot)

A centrin-1 that is encoded in the genome of human.


TFCP2_HUMAN Alpha-globin transcription factor CP2 (sprot)

An alpha-globin transcription factor CP2 that is encoded in the genome of human.


AKP13_HUMAN A-kinase anchor protein 13 (sprot)

An A-kinase anchor protein 13 that is encoded in the genome of human.


regulation of sarcomere organization

Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


FBLN3_HUMAN EGF-containing fibulin-like extracellular matrix protein 1 (sprot)

An EGF-containing fibulin-like extracellular matrix protein 1 that is encoded in the genome of human.


KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2 (sprot)

A voltage-gated potassium channel KCNH2 that is encoded in the genome of human.


negative regulation of potassium ion export across plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane.


TROAP_HUMAN Tastin (sprot)

A trophinin-associated protein that is encoded in the genome of human.


TROP_HUMAN Trophinin (sprot)

A trophinin that is encoded in the genome of human.


SNF5_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (sprot)

A SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 that is encoded in the genome of human.


single stranded viral RNA replication via double stranded DNA intermediate

A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II.


RB40B_HUMAN Ras-related protein Rab-40B (sprot)

A Ras-related protein Rab-40B that is encoded in the genome of human.


BPTF_HUMAN Nucleosome-remodeling factor subunit BPTF (sprot)

A nucleosome-remodeling factor subunit BPTF that is encoded in the genome of human.


CDC20_HUMAN Cell division cycle protein 20 homolog (sprot)

A cell division cycle protein 20 homolog that is encoded in the genome of human.


metaphase/anaphase transition of cell cycle

The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle.


metaphase/anaphase transition of meiosis I

The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I.


ZP4_HUMAN Zona pellucida sperm-binding protein 4 (sprot)

A zona pellucida sperm-binding protein 4 that is encoded in the genome of human.


PO4F2_HUMAN POU domain, class 4, transcription factor 2 (sprot)

A POU domain, class 4, transcription factor 2 that is encoded in the genome of human.


regulation of retinal ganglion cell axon guidance

Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.


KIF5A_HUMAN Kinesin heavy chain isoform 5A (sprot)

A kinesin heavy chain isoform 5A that is encoded in the genome of human.


FSTL1_HUMAN Follistatin-related protein 1 (sprot)

A follistatin-related protein 1 that is encoded in the genome of human.


STX4_HUMAN Syntaxin-4 (sprot)

A syntaxin-4 that is encoded in the genome of human.


sphingomyelin phosphodiesterase activator activity

Binds to and increases the activity of the enzyme sphingomyelin phosphodiesterase.


organelle fusion

The creation of a single organelle from two or more organelles.


neuron projection membrane

The portion of the plasma membrane surrounding a neuron projection.


lateral loop

Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.


GRSF1_HUMAN G-rich sequence factor 1 (sprot)

A G-rich sequence factor 1 that is encoded in the genome of human.


positive regulation of mitochondrial RNA catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.


M4K2_HUMAN Mitogen-activated protein kinase kinase kinase kinase 2 (sprot)

A mitogen-activated protein kinase kinase kinase kinase 2 that is encoded in the genome of human.


M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 (sprot)

A mitogen-activated protein kinase kinase kinase 12 that is encoded in the genome of human.


NFIA_HUMAN Nuclear factor 1 A-type (sprot)

A nuclear factor 1 A-type that is encoded in the genome of human.


CNTN1_HUMAN Contactin-1 (sprot)

A contactin-1 that is encoded in the genome of human.


CAD17_HUMAN Cadherin-17 (sprot)

A cadherin-17 that is encoded in the genome of human.


oligopeptide transport

The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


positive regulation of integrin activation by cell surface receptor linked signal transduction

Any process that activates or increases the frequency, rate, or extent of integrin activation by cell surface receptor linked signal transduction. This can occur by increased affinity of an integrin for its extracellular ligands.


oligopeptide transmembrane transport

The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


MERTK_HUMAN Tyrosine-protein kinase Mer (sprot)

A tyrosine-protein kinase Mer that is encoded in the genome of human.


TCF15_HUMAN Transcription factor 15 (sprot)

A transcription factor 15 that is encoded in the genome of human.


SFSWA_HUMAN Splicing factor, suppressor of white-apricot homolog (sprot)

A splicing factor, arginine/serine-rich 8 that is encoded in the genome of human.


CHD3_HUMAN Chromodomain-helicase-DNA-binding protein 3 (sprot)

A chromodomain-helicase-DNA-binding protein 3 that is encoded in the genome of human.


SF3A3_HUMAN Splicing factor 3A subunit 3 (sprot)

A splicing factor 3A subunit 3 that is encoded in the genome of human.


NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (sprot)

A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human.


sleep

Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.


directional locomotion

Self-propelled movement of a cell or organism from one location to another along an axis.


protein localization to postsynaptic membrane

A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane.


DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP(+)] (sprot)

A dihydropyrimidine dehydrogenase [NADP(+)] that is encoded in the genome of human.


dihydropyrimidine dehydrogenase (NADP+) activity

Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+.


purine nucleobase catabolic process

The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.


pyrimidine nucleobase catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


uracil catabolic process

The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.


thymidine catabolic process

The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.


CMP catabolic process

The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate.


beta-alanine biosynthetic process

The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.


UMP catabolic process

The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate.


dUMP catabolic process

The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate.


SEPR_HUMAN Prolyl endopeptidase FAP (sprot)

A prolyl endopeptidase FAP that is encoded in the genome of human.


negative regulation of extracellular matrix organization

Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization.


peptidase complex

A protein complex which is capable of peptidase activity.


COX10_HUMAN Protoheme IX farnesyltransferase, mitochondrial (sprot)

A protoheme IX farnesyltransferase, mitochondrial that is encoded in the genome of human.


protoheme IX farnesyltransferase activity

Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate.


heme A biosynthetic process

The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3.


TP53B_HUMAN TP53-binding protein 1 (sprot)

A TP53-binding protein 1 that is encoded in the genome of human.


ubiquitin modification-dependent histone binding

Binding to a histone protein in which a residue has been modified by ubiquitination.


OVGP1_HUMAN Oviduct-specific glycoprotein (sprot)

An oviduct-specific glycoprotein that is encoded in the genome of human.


perivitelline space

The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane).


HYAL2_HUMAN Hyaluronidase-2 (sprot)

A hyaluronidase-2 that is encoded in the genome of human.


receptor signaling protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.


TM115_HUMAN Transmembrane protein 115 (sprot)

A transmembrane protein 115 that is encoded in the genome of human.


IFRD2_HUMAN Interferon-related developmental regulator 2 (sprot)

An interferon-related developmental regulator 2 that is encoded in the genome of human.


TRI26_HUMAN Tripartite motif-containing protein 26 (sprot)

A tripartite motif-containing protein 26 that is encoded in the genome of human.


ZN155_HUMAN Zinc finger protein 155 (sprot)

A zinc finger protein 155 that is encoded in the genome of human.


AIMP1_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (sprot)

An aminoacyl tRNA synthase complex-interacting multifunctional protein 1 that is encoded in the genome of human.


positive regulation of glucagon secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.


ILF2_HUMAN Interleukin enhancer-binding factor 2 (sprot)

An interleukin enhancer-binding factor 2 that is encoded in the genome of human.


ILF3_HUMAN Interleukin enhancer-binding factor 3 (sprot)

An interleukin enhancer-binding factor 3 that is encoded in the genome of human.


LMAN2_HUMAN Vesicular integral-membrane protein VIP36 (sprot)

A vesicular integral-membrane protein VIP36 that is encoded in the genome of human.


NTCP2_HUMAN Ileal sodium/bile acid cotransporter (sprot)

An ileal sodium/bile acid cotransporter that is encoded in the genome of human.


bile acid:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in).


IRAG2_HUMAN Inositol 1,4,5-triphosphate receptor associated 2 (sprot)

An inositol 1,4,5-triphosphate receptor associated 2 that is encoded in the genome of human.


PTPRJ_HUMAN Receptor-type tyrosine-protein phosphatase eta (sprot)

A receptor-type tyrosine-protein phosphatase eta that is encoded in the genome of human.


KLRB1_HUMAN Killer cell lectin-like receptor subfamily B member 1 (sprot)

A killer cell lectin-like receptor subfamily B member 1 that is encoded in the genome of human.


PTN13_HUMAN Tyrosine-protein phosphatase non-receptor type 13 (sprot)

A tyrosine-protein phosphatase non-receptor type 13 that is encoded in the genome of human.


negative regulation of excitatory synapse assembly

Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse assembly.


ELAV2_HUMAN ELAV-like protein 2 (sprot)

An ELAV-like protein 2 that is encoded in the genome of human.


EPS8_HUMAN Epidermal growth factor receptor kinase substrate 8 (sprot)

An epidermal growth factor receptor kinase substrate 8 that is encoded in the genome of human.


TRAP1_HUMAN Heat shock protein 75 kDa, mitochondrial (sprot)

A heat shock protein 75 kDa, mitochondrial that is encoded in the genome of human.


translational attenuation

Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.


negative regulation of cellular respiration

Any process that stops, prevents or reduces the frequency, rate or extent of cellular respiration.


TRAF2_HUMAN TNF receptor-associated factor 2 (sprot)

A TNF receptor-associated factor 2 that is encoded in the genome of human.


programmed necrotic cell death

A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.


BFSP1_HUMAN Filensin (sprot)

A filensin that is encoded in the genome of human.


FOXF1_HUMAN Forkhead box protein F1 (sprot)

A forkhead box protein F1 that is encoded in the genome of human.


detection of wounding

The series of events by which an injury stimulus is received and converted into a molecular signal.


respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.


lateral mesodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell.


embryonic ectodermal digestive tract morphogenesis

The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal digestive tract are generated and organized.


right lung morphogenesis

The process in which anatomical structures of the right lung are generated and organized.


FOXF2_HUMAN Forkhead box protein F2 (sprot)

A forkhead box protein F2 that is encoded in the genome of human.


regulation of protein polyubiquitination

Any process that modulates the frequency, rate or extent of protein polyubiquitination.


FOXC1_HUMAN Forkhead box protein C1 (sprot)

A forkhead box protein C1 that is encoded in the genome of human.


apoptotic process involved in outflow tract morphogenesis

Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.


glomerular epithelium development

The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.


positive regulation of hematopoietic stem cell differentiation

Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation.


negative regulation of apoptotic process involved in outflow tract morphogenesis

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.


FOXD4_HUMAN Forkhead box protein D4 (sprot)

A forkhead box protein D4 that is encoded in the genome of human.


FOXI1_HUMAN Forkhead box protein I1 (sprot)

A forkhead box protein I1 that is encoded in the genome of human.


FOXL1_HUMAN Forkhead box protein L1 (sprot)

A forkhead box protein L1 that is encoded in the genome of human.


visceral mesoderm-endoderm interaction involved in midgut development

The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut.


ANK3_HUMAN Ankyrin-3 (sprot)

An ankyrin-3 that is encoded in the genome of human.


positive regulation of cell communication by electrical coupling

Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


maintenance of protein location in plasma membrane

Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere.


positive regulation of membrane depolarization during cardiac muscle cell action potential

Any process that activates or increases the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential.


DLG1_HUMAN Disks large homolog 1 (sprot)

A disks large homolog 1 that is encoded in the genome of human.


structural constituent of postsynaptic density

The action of a molecule that contributes to the structural integrity of a postsynaptic density.


regulation of protein localization to synapse

Any process that modulates the frequency, rate or extent of protein localization to synapse.


regulation of potassium ion import

Any process that modulates the frequency, rate or extent of potassium ion import.


regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.


regulation of potassium ion export across plasma membrane

Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane.


MPP7-DLG1-LIN7 complex

A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions.


TAF10_HUMAN Transcription initiation factor TFIID subunit 10 (sprot)

A transcription initiation factor TFIID subunit 10 that is encoded in the genome of human.


SAGA complex assembly

The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof.


MYO1E_HUMAN Unconventional myosin-Ie (sprot)

A myosin-Ie that is encoded in the genome of human.


nitrogen compound metabolic process

The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.


GNDS_HUMAN Ral guanine nucleotide dissociation stimulator (sprot)

A Ral guanine nucleotide dissociation stimulator that is encoded in the genome of human.


NFAC3_HUMAN Nuclear factor of activated T-cells, cytoplasmic 3 (sprot)

A nuclear factor of activated T-cells, cytoplasmic 3 that is encoded in the genome of human.


PP1R8_HUMAN Nuclear inhibitor of protein phosphatase 1 (sprot)

A nuclear inhibitor of protein phosphatase 1 that is encoded in the genome of human.


ribonuclease E activity

Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group.


TP4A2_HUMAN Protein tyrosine phosphatase type IVA 2 (sprot)

A protein tyrosine phosphatase type IVA 2 that is encoded in the genome of human.


ABR_HUMAN Active breakpoint cluster region-related protein (sprot)

An active breakpoint cluster region-related protein that is encoded in the genome of human.


NPRL3_HUMAN GATOR1 complex protein NPRL3 (sprot)

A GATOR complex protein NPRL3 that is encoded in the genome of human.


SEC20_HUMAN Vesicle transport protein SEC20 (sprot)

A vesicle transport protein SEC20 that is encoded in the genome of human.


endoplasmic reticulum membrane fusion

The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.


apoptotic process in response to mitochondrial fragmentation

Any apoptotic process that occurs as a result of mitochondrial fragmentation.


BNIP2_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (sprot)

A BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 that is encoded in the genome of human.


BNIP3_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (sprot)

A BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 that is encoded in the genome of human.


negative regulation of membrane potential

Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


NFX1_HUMAN Transcriptional repressor NF-X1 (sprot)

A transcriptional repressor NF-X1 that is encoded in the genome of human.


HSPB3_HUMAN Heat shock protein beta-3 (sprot)

A heat shock protein beta-3 that is encoded in the genome of human.


CSTF3_HUMAN Cleavage stimulation factor subunit 3 (sprot)

A cleavage stimulation factor subunit 3 that is encoded in the genome of human.


mRNA cleavage stimulating factor complex

A protein complex required for mRNA cleavage but not for poly(A) addition.


TSN31_HUMAN Tetraspanin-31 (sprot)

A tetraspanin-31 that is encoded in the genome of human.


GRIK2_HUMAN Glutamate receptor ionotropic, kainate 2 (sprot)

A glutamate receptor ionotropic, kainate 2 that is encoded in the genome of human.


extracellularly glutamate-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.


detection of cold stimulus involved in thermoception

The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception.


mossy fiber rosette

A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes.


GRIK3_HUMAN Glutamate receptor ionotropic, kainate 3 (sprot)

A glutamate receptor ionotropic, kainate 3 that is encoded in the genome of human.


adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.


IL24_HUMAN Interleukin-24 (sprot)

An interleukin-24 that is encoded in the genome of human.


TIAM1_HUMAN Rho guanine nucleotide exchange factor TIAM1 (sprot)

A Rho guanine nucleotide exchange factor TIAM1 that is encoded in the genome of human.


positive regulation of Schwann cell chemotaxis

Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis.


extrinsic component of postsynaptic density membrane

The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


ECH1_HUMAN Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (sprot)

A Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial that is encoded in the genome of human.


AF1Q_HUMAN Protein AF1q (sprot)

A protein AF1q that is encoded in the genome of human.


RHG05_HUMAN Rho GTPase-activating protein 5 (sprot)

A Rho GTPase-activating protein 5 that is encoded in the genome of human.


PLA2R_HUMAN Secretory phospholipase A2 receptor (sprot)

A secretory phospholipase A2 receptor that is encoded in the genome of human.


negative regulation of arachidonic acid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion.


MALL_HUMAN MAL-like protein (sprot)

A MAL-like protein that is encoded in the genome of human.


AKAP6_HUMAN A-kinase anchor protein 6 (sprot)

An A-kinase anchor protein 6 that is encoded in the genome of human.


PRDM2_HUMAN PR domain zinc finger protein 2 (sprot)

A PR domain zinc finger protein 2 that is encoded in the genome of human.


STRN3_HUMAN Striatin-3 (sprot)

A striatin-3 that is encoded in the genome of human.


CDC16_HUMAN Cell division cycle protein 16 homolog (sprot)

A cell division cycle protein 16 that is encoded in the genome of human.


STK4_HUMAN Serine/threonine-protein kinase 4 (sprot)

A serine/threonine-protein kinase 4 that is encoded in the genome of human.


neural tube formation

The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.


primitive hemopoiesis

A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells.


regulation of cell differentiation involved in embryonic placenta development

Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state.


positive regulation of hepatocyte apoptotic process

Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process.


FLII_HUMAN Protein flightless-1 homolog (sprot)

A protein flightless-1 that is encoded in the genome of human.


PSG7_HUMAN Pregnancy-specific beta-1-glycoprotein 7 (sprot)

A pregnancy-specific beta-1-glycoprotein 7 that is encoded in the genome of human.


TRI32_HUMAN E3 ubiquitin-protein ligase TRIM32 (sprot)

An E3 ubiquitin-protein ligase TRIM32 that is encoded in the genome of human.


actin ubiquitination

The modification of actin by addition of ubiquitin groups.


positive regulation of interleukin-17-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of interleukin-17-mediated signaling pathway.


positive regulation of chemokine (C-C motif) ligand 20 production

Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 20 production.


COASY_HUMAN Bifunctional coenzyme A synthase (sprot)

A bifunctional coenzyme A synthase that is encoded in the genome of human.


dephospho-CoA kinase activity

Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+.


Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate.


TRDN_HUMAN Triadin (sprot)

A triadin that is encoded in the genome of human.


positive regulation of cell communication by electrical coupling involved in cardiac conduction

Any process that activates or increases the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction.


junctional membrane complex

Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules).


MKRN3_HUMAN Probable E3 ubiquitin-protein ligase makorin-3 (sprot)

A makorin-3 that is encoded in the genome of human.


GAG2B_HUMAN G antigen 2B/2C (sprot)

A G antigen 2B/2C that is encoded in the genome of human.


GAGE5_HUMAN G antigen 5 (sprot)

A G antigen 5 that is encoded in the genome of human.


BAGE1_HUMAN B melanoma antigen 1 (sprot)

A B melanoma antigen 1 that is encoded in the genome of human.


BIRC1_HUMAN Baculoviral IAP repeat-containing protein 1 (sprot)

A baculoviral IAP repeat-containing protein 1 that is encoded in the genome of human.


TRAF1_HUMAN TNF receptor-associated factor 1 (sprot)

A TNF receptor-associated factor 1 that is encoded in the genome of human.


RM28_HUMAN Large ribosomal subunit protein bL28m (sprot)

A 39S ribosomal protein L28, mitochondrial that is encoded in the genome of human.


ACACA_HUMAN Acetyl-CoA carboxylase 1 (sprot)

An acetyl-CoA carboxylase 1 that is encoded in the genome of human.


PDIA2_HUMAN Protein disulfide-isomerase A2 (sprot)

A protein disulfide-isomerase A2 that is encoded in the genome of human.


PAFA_HUMAN Platelet-activating factor acetylhydrolase (sprot)

A platelet-activating factor acetylhydrolase that is encoded in the genome of human.


lipid oxidation

The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.


plasma lipoprotein particle oxidation

The modification of a lipid or protein within a plasma lipoprotein particle by oxidation of the lipid or one or more amino acids.


LCP2_HUMAN Lymphocyte cytosolic protein 2 (sprot)

A lymphocyte cytosolic protein 2 that is encoded in the genome of human.


CSN1_HUMAN COP9 signalosome complex subunit 1 (sprot)

A COP9 signalosome complex subunit 1 that is encoded in the genome of human.


IFT88_HUMAN Intraflagellar transport protein 88 homolog (sprot)

An intraflagellar transport protein 88 that is encoded in the genome of human.


SPP24_HUMAN Secreted phosphoprotein 24 (sprot)

A secreted phosphoprotein 24 that is encoded in the genome of human.


ZBT17_HUMAN Zinc finger and BTB domain-containing protein 17 (sprot)

A zinc finger and BTB domain-containing protein 17 that is encoded in the genome of human.


ZN154_HUMAN Zinc finger protein 154 (sprot)

A zinc finger protein 154 that is encoded in the genome of human.


UBP4_HUMAN Ubiquitin carboxyl-terminal hydrolase 4 (sprot)

A ubiquitin carboxyl-terminal hydrolase 4 that is encoded in the genome of human.


adenosine receptor binding

Binding to an adenosine receptor.


CAF1A_HUMAN Chromatin assembly factor 1 subunit A (sprot)

A chromatin assembly factor 1 subunit A that is encoded in the genome of human.


CAF1B_HUMAN Chromatin assembly factor 1 subunit B (sprot)

A chromatin assembly factor 1 subunit B that is encoded in the genome of human.


PDZ1I_HUMAN PDZK1-interacting protein 1 (sprot)

A PDZK1-interacting protein 1 that is encoded in the genome of human.


TRAF3_HUMAN TNF receptor-associated factor 3 (sprot)

A TNF receptor-associated factor 3 that is encoded in the genome of human.


DUS4_HUMAN Dual specificity protein phosphatase 4 (sprot)

A dual specificity protein phosphatase 4 that is encoded in the genome of human.


protein tyrosine/threonine phosphatase activity

Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


MAP kinase serine/threonine phosphatase activity

Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate.


DAZ2_HUMAN Deleted in azoospermia protein 2 (sprot)

A deleted in azoospermia protein 2 that is encoded in the genome of human.


KLF10_HUMAN Krueppel-like factor 10 (sprot)

A krueppel-like factor 10 that is encoded in the genome of human.


RED_HUMAN Protein Red (sprot)

A protein Red that is encoded in the genome of human.


MTAP_HUMAN S-methyl-5'-thioadenosine phosphorylase (sprot)

An S-methyl-5'-thioadenosine phosphorylase that is encoded in the genome of human.


L-methionine salvage from methylthioadenosine

The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.


REST_HUMAN RE1-silencing transcription factor (sprot)

An RE1-silencing transcription factor that is encoded in the genome of human.


negative regulation of dense core granule biogenesis

Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis.


negative regulation of amniotic stem cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation.


RLF_HUMAN Zinc finger protein Rlf (sprot)

A zinc finger protein Rlf that is encoded in the genome of human.


AAPK1_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-1 (sprot)

A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of human.


cold acclimation

Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.


negative regulation of glucosylceramide biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


positive regulation of mitochondrial transcription

Any process that activates or increases the frequency, rate or extent of transcription occuring in the mitochondrion.


NR1H3_HUMAN Oxysterols receptor LXR-alpha (sprot)

An oxysterols receptor LXR-alpha that is encoded in the genome of human.


negative regulation of pancreatic juice secretion

Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.


negative regulation of secretion of lysosomal enzymes

Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.


LIPA1_HUMAN Liprin-alpha-1 (sprot)

A liprin-alpha-1 that is encoded in the genome of human.


CACO2_HUMAN Calcium-binding and coiled-coil domain-containing protein 2 (sprot)

A calcium-binding and coiled-coil domain-containing protein 2 that is encoded in the genome of human.


EI2BE_HUMAN Translation initiation factor eIF-2B subunit epsilon (sprot)

A translation initiation factor eIF-2B subunit epsilon that is encoded in the genome of human.


BAMBI_HUMAN BMP and activin membrane-bound inhibitor homolog (sprot)

A BMP and activin membrane-bound inhibitor that is encoded in the genome of human.


TADBP_HUMAN TAR DNA-binding protein 43 (sprot)

A TAR DNA-binding protein 43 that is encoded in the genome of human.


nuclear inner membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane.


ROA0_HUMAN Heterogeneous nuclear ribonucleoprotein A0 (sprot)

A heterogeneous nuclear ribonucleoprotein A0 that is encoded in the genome of human.


PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (sprot)

A serine/threonine-protein kinase PAK 1 that is encoded in the genome of human.


AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (sprot)

An aminoacyl tRNA synthase complex-interacting multifunctional protein 2 that is encoded in the genome of human.


RFA4_HUMAN Replication protein A 30 kDa subunit (sprot)

A replication protein A 30 kDa subunit that is encoded in the genome of human.


nuclear DNA replication

The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.


FADD_HUMAN FAS-associated death domain protein (sprot)

A FAS-associated death domain protein that is encoded in the genome of human.