AIDS

A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood.


Stavudine

A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase


Deep Brain Stimulation

biolink:Procedure biolink:NamedThing biolink:Entity biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


ventral anterior nucleus of thalamus

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The ventral anterior nucleus is a nucleus of the thalamus.


Decreased heart rate variability

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

Reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle.


calcium/calmodulin-dependent protein kinase type II chain

A protein with a core domain architecture consisting of a Protein kinase domain (Pfam:PF00069) and a C-terminal Calcium/calmodulin dependent protein kinase II Association (Pfam:PF08332) domain.


Methoxybenzene-sulfonamide

A sulfonamide resulting from the formal condensation of p-methoxybenzenesulfonic acid with the anilino nitrogen of 2-(aminomethyl)-N-(2-hydroxyethyl)aniline in which the hydrogens of the primary amino group have been replaced by methyl and p-chlorocinnamyl groups. KN-93 is a selective inhibitor of  Ca(2+)/calmodulin-dependent protein kinase II.


knee pain increased by descending stairs


Prescription Opioid Misuse

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon


phospholipase A and acyltransferase 5

A protein that is a translation product of the human PLAAT5 gene or a 1:1 ortholog thereof.


Deafness, encephaloneuropathy, obesity, valvulopathy syndrome


mental health

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


sleep

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.


Negative

biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon


A0A8H7M5Y4_9AGAM Putative ER transporter, 6TM, N-terminal (trembl)


A0A5K1VK93_ENTHI Single tm domain protein (trembl)


Pegylated CD25/CD122-selective Interleukin-2 Mutein STK-012


A0A8C0QCE6_CANLF Opioid related nociceptin receptor 1 (trembl)


Preparatory sensory information

biolink:Activity biolink:NamedThing biolink:Entity biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


BMP signaling pathway involved in determination of left/right symmetry

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry.


Parasitic Infection Pathways (Homo sapiens)


opioid-induced constipation

A constipation disorder caused by use of opiods. OIC may present immediately when a patient takes the opioid, or it may present gradually during opioid therapy.


GI

A protein that is a translation product of the GI gene in Arabidopsis thaliana.


Alfentanil

A member of the class of piperidines that is piperidine having a 2-(4-ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl group at the 1-position as well as N-phenylpropanamido- and methoxymethyl groups at the 4-position.


Sufentanil

An anilide resulting from the formal condensation of the aryl amino group of 4-(methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid.


Sleep

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Pittsburgh sleep quality index

biolink:Publication biolink:InformationContentEntity biolink:NamedThing biolink:Entity


Liraglutide

A lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.


Suvorexant

An aromatic amide obtained by formal condensation of the carboxy group of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid with the secondary amino group of 5-chloro-2-[(5R)-5-methyl-1,4-diazepan-1-yl]-1,3-benzoxazole. An orexin receptor antagonist used for the management of insomnia.


A mu-type opioid receptor that is encoded in the genome of mouse.


Liver cancer antibodies & Alpha-1-Fetoprotein


Seeking advice or assistance from caregivers or professionals


Relapse Following Intervention for Kawasaki Disease

An indication that there was a relapse following treatment for Kawasaki disease.


Insulin Human

An insulin that is produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two peptide chains, one containing 21 amino acid residues and the other containing 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into E. coli, which then produces insulin for human use. It is used in the treatment of type I and type II diabetes.


Transcutaneous stimulation of cervical branch of vagus nerve


Distress

A state of physiological or psychological stress that cannot be compensated for by normal adaptive measures.


Forskolin

A labdane diterpenoid isolated from the Indian Coleus plant.


pain reprocessing by transcutaneous electrical modulation


Body mass index

biolink:ClinicalAttribute biolink:Attribute biolink:NamedThing biolink:Entity biolink:OntologyClass


leptin

A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof.


Pelvic Floor Muscle Weakness

A reduction in the strength of the muscles of the pelvic floor.


Chronic Prostatitis with Chronic Pelvic Pain Syndrome


Rural Communities

biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:SubjectOfInvestigation biolink:ThingWithTaxon


digital therapeutics for opioid use disorder


High-Risk Pregnancy

A fetal/maternal condition that is risky and portends complications for the mother and/or fetus, when compared to a normal pregnancy.


Kentucky (geographic area)

biolink:GeographicLocation biolink:PlanetaryEntity biolink:NamedThing biolink:Entity


Radionuclide therapy for chronic leukemia


Community

biolink:Agent biolink:AdministrativeEntity biolink:NamedThing biolink:Entity


Health Personnel

biolink:Cohort biolink:StudyPopulation biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:SubjectOfInvestigation biolink:ThingWithTaxon


exposure to tobacco smoke in perinatal period


outcomes general productivity developmental


Jaundice, Hemolytic

Jaundice occurring as a result of red blood cell rupture.


strabismus

Strabismus is the intermittent or constant misalignment of an eye so that its line of vision is not pointed at the same object as the other eye. Strabismus is caused by an imbalance in the extraocular muscles which control the positioning of the eyes. Strabismus is normal in newborns but should resolve by the time the baby is 6 months old. In older children with strabismus, the brain may learn to ignore the input from one eye, and this may lead to amblyopia, a potentially permanent decrease in vision in that eye if not corrected.


Hydroxyzine

A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.


Opioids in combination with antispasmodics


Subcortical

Denoting the area below a cortex.


dynamic microtubule bundle

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A microtubule bundle that undergoes changes in length, and in which microtubule sliding takes place.


Resting Functional Magnetic Resonance Imaging

biolink:Procedure biolink:NamedThing biolink:Entity biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


neurobehavioral disorder with prenatal alcohol exposure

A fetal alcohol spectrum disorder that is characterized by one or more deficits in neurocognition and in self-regulation plus two or more deficits in adaptive functioning, with at least 1 in communication or social communication and interaction.


cerebellar dysfunction with variable cognitive and behavioral abnormalities

Non-progressive cerebellar ataxia with intellectual deficit is a rare subtype of autosomal dominant cerebellar ataxia type 1 (ADCA type 1) characterized by the onset in infancy of cerebellar ataxia, neonatal hypotonia (in some), mild developmental delay and, in later life, intellectual disability. Less common features include dysarthria, dysmetria and dysmorphic facial features (long face, bulbous nose long philtrum, thick lower lip and pointed chin).


end stage renal failure

Long-standing and persistent renal disease with glomerular filtration rate (GFR) less than 15 ml/min.


chronic kidney disease

Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.


Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)


disease (or disorder); kidney, complicating pregnancy


therapy prescribed for long-term asthma management


endometriosis

The growth of functional endometrial tissue in anatomic sites outside the uterine body. It most often occurs in the pelvic organs.


adenomyosis

The growth of endometrial tissue inside the muscular wall of the uterine corpus. Clinical manifestations include pain, dysmenorrhea, and menorrhagia.


Assessment using Therapy Outcome Measure


Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE


AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE


Hepatitis C Virus Positive

Indicates that hepatitis C virus has been detected in a sample.


stigma development

The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky.


National Center for Health Statistics, U.S.


National Center for Advancing Translational Sciences (U.S.)


Extension for Community Healthcare Outcomes


contact with recently incarcerated persons


sexually transmitted disease

A Disease due to or propagated by sexual contact.


Epispadias

Epispadias is a urogenital malformation characterized by the failure of the urethral tube to tubularize on the dorsal aspect. Unlike in hypospadias, where the meatus is on the ventral aspect, children with epispadias have a wide-open urethral plate on the dorsum. It is commonly seen as a component in the spectrum of bladder exstrophy-epispadias-complex. Isolated epispadias constitutes less than 10 percent of the total cases of epispadias.


Enrolled in Medicaid health insurance coverage


Antigenic valence

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Wearable Electronic Devices

biolink:PhysicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:PhysicalEssenceOrOccurrent


transcutaneous auricular stimulation with setup, calibration, patient education on equipment use


vagus nerve

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart).


trigeminal nerve

Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw).


Blood alcohol concentration

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon


sweat

Secretion produced by a sweat gland.


High risk sexual behavior

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


cranial or facial muscle

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


lung cancer

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon

A malignant neoplasm involving the lung.


Immune Dysregulation Disorder

A group of autoimmune disorders characterized by defects in self-tolerance (central or peripheral) resulting in autoimmune disease with or without recurrent infections, comprised by: Familial hemophagocytic lymphohistiocytosis (FHL) syndromes; FHL syndromes with hypopigmentation; Regulatory T cell (Treg) defects (eg, IPEX); Autoimmunity with or without lymphoproliferation (eg, autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy [APECED]); Autoimmune lymphoproliferative syndrome (ALPS); Immune dysregulation with colitis; and Susceptibility to Epstein-Barr virus (EBV) and lymphoproliferative conditions.


Deficits in attention motor control and perception


SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS


epilepsy

A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.


facial neuralgia

Neuralgic syndromes which feature chronic or recurrent facial pain as the primary manifestation of disease. Disorders of the trigeminal and facial nerves are frequently associated with these conditions.


A C-C chemokine receptor type 5 that is encoded in the genome of human.


A C-C chemokine receptor type 8 that is encoded in the genome of human.


A C-C motif chemokine 3 that is encoded in the genome of human.


hyaline cartilage tissue

Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.


A runt-related transcription factor 2 that is encoded in the genome of human.


iPSC-derived Natural Killer Cells FT500

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A preparation of off-the-shelf, natural killer (NK) cells derived from a clonal master induced pluripotent stem cell (iPSC) line, with potential antineoplastic and immunostimulatory activities. Upon administration, iPSC-derived natural killer cells FT500 bind to stress-induced ligands on tumor cells, leading to tumor cell lysis and release of tumor neoantigens. Additionally, iPSC-NK cells secrete inflammatory cytokines and chemokines including interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), C-C motif chemokines 3, 4, and 22 (CCL3, CCL4, and CCL22), and C-X-C motif chemokine 10 (CXCL10), thereby enhancing T-cell activity and recruitment to the tumor site.


Lidocaine

The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.


graphene oxide

A single carbon layer of the graphite oxide structure.


neurotransmitter agent

A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.


A0A068WIZ4_ECHGR High voltage activated calcium channel beta (trembl)


inhibition of generation of L-type calcium current

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


neuronal stem cell division

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The self-renewing division of a neuronal stem cell.


A0A6G5VBU0_HEMLE Analgesic peptide (trembl)


A serine/threonine-protein kinase 25 that is encoded in the genome of human.


A cAMP-dependent protein kinase type I-alpha regulatory subunit that is encoded in the genome of human.


psychiatric disorder

A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia.


Affective Disorders, Psychotic

The manifestation of psychotic symptoms, such as hallucinations or delusions, in the presence of a mood disorder.


Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels


A0A1E1GJG6_MOUSE Single-chain variable (trembl)


Anti-CD20 B9E9 scFv-Streptavidin Fusion Protein


A Mas-related G-protein coupled receptor X1 that is encoded in the genome of human.


Pulmonary hypertension due to sleep-disordered breathing


obstructive sleep apnea syndrome

Cessation of air flow during sleep due to upper airway obstruction.


complex sleep apnea

A distinct form of sleep-disordered breathing characterized as central sleep apnea (CSA), and presents in obstructive sleep apnea (OSA) patients during initial treatment with a continuous positive airway pressure (CPAP) device.


apnea, central sleep

The periodic cessation of breathing while asleep that occurs secondary to the decreased responsiveness of the respiratory center of the brain to carbon dioxide, resulting in alternating cycles of apnea and hyperpnea.


Airway structure

The part of the respiratory system between the nose or mouth and the lungs.


Transcutaneous Electric Nerve Stimulation


Brief Pain Inventory

biolink:Publication biolink:InformationContentEntity biolink:NamedThing biolink:Entity


biolink:ClinicalAttribute biolink:Attribute biolink:NamedThing biolink:Entity biolink:OntologyClass


self-inflicted overdose of pharmaceutical excipients


ventral striatum

A composite structure of the telencephalon that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the anterior perforated substance, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance (Heimer-1995; adapted from Brain Info).


American Indians

biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Alaska

biolink:GeographicLocation biolink:PlanetaryEntity biolink:NamedThing biolink:Entity


anxiolytic drug

Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.


Mental Health @ None @ Psychological Tests @ Personality and Behavioral


Victimization

biolink:Phenomenon biolink:NamedThing biolink:Entity biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Prescription procedure

biolink:Activity biolink:NamedThing biolink:Entity biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Treatment related leukaemia

A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor or exposure to ionizing radiation.


Painkillers, for example, codeine, darvon, percodan, oxycontin, dilaudid, demerol, celebrex or vioxx


child protective services referral to parenting resources


Probation officer

biolink:Cohort biolink:StudyPopulation biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Joint disorders and dislocations; trauma-related


opioid analgesic

A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.


United States Dept. of Health and Human Services

biolink:Agent biolink:AdministrativeEntity biolink:NamedThing biolink:Entity


Adjustment disorder with mixed anxiety and depressed mood


statin (semi-synthetic)

A statin that is derived from a naturally occurring statin by partial chemical synthesis.


ADHD, predominantly hyperactive - impulsive


urine

Excretion that is the output of a kidney.


Hair Preparations

biolink:PhysicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:PhysicalEssenceOrOccurrent


gynaecological check up

biolink:Procedure biolink:NamedThing biolink:Entity biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Sex assigned at birth

biolink:OrganismAttribute biolink:Attribute biolink:NamedThing biolink:Entity biolink:OntologyClass


care; infant, lack of

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon


anthrax vaccine, for intramuscular use (medication)


Substance Abuse Treatment Drug Pharmacogenetic Test Reagents


A myelodysplastic syndrome caused by chemotherapy and/or radiotherapy.


National Institute of Allergy and Infectious Diseases (U.S.)


autism spectrum disorder

A spectrum of developmental disorders that includes autism, and Asperger syndrome. Signs and symptoms include poor communication skills, defective social interactions, and repetitive behaviors.


Other psychoactive substance use, unspecified


non-steroidal anti-inflammatory drug

An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.


Alcohol consumption

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


DNA/DNA annealing activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An activity that faciliates the formation of a complementary double-stranded DNA molecule.


Rehabilitation, Substance Use Disorder Unit


Testing for presence of drug, by chemistry analyzers


stabilization exercises for lumbar region


worries; pain or disability

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:ThingWithTaxon


nociceptin

A protein that is a translation product of the human PNOC gene or a 1:1 ortholog thereof.


paraventricular nucleus of thalamus

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The nucleus paraventricularis anterior thalami and nuclues paraventricularis posterior thalami, two of the nuclei mediani thalami; they are situated on the dorsomedial wall of the thalamus, juxtaposed to the third ventricle.


sleep disorder

A change from the patient's baseline sleeping pattern, in the hours slept and/or an alteration/dysfunction in the stages of sleep.


Sleep, Slow-Wave

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Sleep disturbance

An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness.


Extracellular

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


A disorder characterized by a marked pattern of inattention and/or hyperactivity-impulsivity that is inconsistent with developmental level and clearly interferes with functioning in at least two settings (e.g. at home and at school). When present, the symptoms of hyperactivity are most often present before the age of 7 years. There are three recognized presentations or subtypes from most to least common: combined type, inattentive/distractible type, hyperactive/impulsive type.


Dopamine

Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.


GABA agent

A substance, such as agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function, used for its pharmacological actions on GABAergic systems.


A neuronal PAS domain-containing protein 2 that is encoded in the genome of human.


tolerance; pancreatic, decreased (steatorrhea)


Hypersensitivity disease of liver caused by drug


pulsed magnetic neuromodulation for incontinence, per day


Neurostimulation procedures of spinal cord tissue


paraplegia

Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord.


conus medullaris

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The conus medullaris is the terminal end of the spinal cord. It occurs near lumbar vertebral levels 1 (L1) and 2 (L2). After the spinal cord tapers out, the spinal nerves continue as dangling nerve roots called cauda equina. This terminal nerve root tail is referred to as the filum terminale. The upper end of the conus medullaris is usually not well defined.


Purkinje Cells

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A large neuron that transmits signals from the cerebellar cortex and play a major role in controlling motor movement.


A caspase-3-like protease that is a translation product of the human CASP3 gene or a 1:1 ortholog thereof.


Pocket erosion

Erosion of patient's skin pocket which houses a device.


implantable cardioverter-defibrillator pulse generator


Vaso-Occlusive Crisis

An exacerbation of sickle cell disease.


Entire intervertebral symphysis between L6 and S1


spinal cord dorsal column

The wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception.


developmental delay, behavioral abnormalities, and neuropsychiatric disorders


Transcranial Doppler ultrasound velocimetry