osteoarthritis susceptibility 1

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

Any osteoarthritis in which the cause of the disease is a mutation in the FRZB gene.


joint damage measurement

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


osteoarthritis

A noninflammatory degenerative joint disease occurring chiefly in older persons, characterized by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.


learning strategies

biolink:Activity biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Decreased Peripheral Respiratory Drive

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Vitreous inflammatory cells

The presence of inflammatory cells such as lymphocytes and macrophages in the vitreous.


innervation (process)

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Grade 3 Laryngeal Inflammation, CTCAE

Severe throat pain; endoscopic intervention indicated


aggrecan core protein

A protein that is a translation product of the human ACAN gene or a 1:1 ortholog thereof.


aggrecan core protein O-glycosylated 32 (human)

An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2240 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-2240, MOD:00002~GNO:G43417UB.


dorsal root ganglion

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain. (MSH) * ganglion found on the posterior root of each spinal nerve, composed of the unipolar nerve cell bodies of the sensory neurons of the nerve. (CSP).


Bone Marrow Cells

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


nociceptor nerve ending

A peripheral terminal of a peripheral, afferent sensory pain receptor cell that is sensitive to injury or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. The nociceptor nerve ending innervates target tissue and transduces noxious stimuli to the central nervous system via some axon(s).


Defective production of gamma-interferon by innate immune cells


Intraepithelial infiltration by lymphocytes, macrophages, plasma cells


Afferent neuron

An afferent neuron that converts environmental stimuli into electrical impulses that are transmitted to the central nervous system.


A C-C motif chemokine 2 that is encoded in the genome of human.


NGF

A beta-nerve growth factor that is encoded in the genome of human.


Paclitaxel

A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.


phosphoprotein pp38, Marek's disease virus


myeloid differentiation primary response protein MyD88

A protein that is a translation product of the human MYD88 gene or a 1:1 ortholog thereof. This protein is an adapter involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.


Oxidative stress response

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


A carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor).


dorsal root ganglion development

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.


spinal cord

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).


A cysteinyl leukotriene receptor 2 that is encoded in the genome of human.


Decreased neurons in dorsal root ganglia


dermatitis

An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis.


Slow stimuli transmission in bilateral peripheral auditory pathways


Neurons

Any of the conducting cells of the nervous system. A typical neuron consists of a cell body, containing the nucleus and the surrounding cytoplasm (perikaryon); several short radiating processes (dendrites); and one long process (the axon), which terminates in twiglike branches (telodendrons) and may have branches (collaterals) projecting along its course.


neurotrophin

A protein that is a neurotrophic polypeptide factor that regulates neuronal differentiation and is essential for neuronal survival, neurite growth and plasticity. It contains a signal peptide, a propeptide, and a C-terminal Nerve growth factor family (Pfam:PF00243) domain.


Defective decussation of certain brainstem neuronal axonal pathways


Facial Tissues

biolink:PhysicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:PhysicalEssenceOrOccurrent


cancer treatment

biolink:Procedure biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Peripheral Nerve Injuries

Sensory or motor loss of peripheral nerve function due to a traumatic event. (ACC)


dorsal horn of spinal cord

The pronounced, dorsolaterally oriented ridge of grey matter in each lateral half of the spinal cord[MP]. the dorsal (more towards the back) grey matter of the spinal cord. It receives several types of sensory information from the body, including light touch, proprioception, and vibration. This information is sent from receptors of the skin, bones, and joints through sensory neurons whose cell bodies lie in the dorsal root ganglion[WP]. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input[GO].


Inflammation

A finding of a localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation.


Chronic pain

Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months.


chronic pain syndrome

Chronic form of disorder involving pain.


toxin

Poisonous substance produced by a biological organism such as a microbe, animal or plant.


type 2 diabetes mellitus

A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.


synovitis

Inflammation of a synovial membrane.


dorsal horn interneuron

A CNS interneuron located in the dorsal horn of the spinal cord.


Cannabigerol

A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species.


Stress

The negative mental, emotional, and physical reactions that occur when environmental stressors are perceived as exceeding the individual's adaptive capacities.


Social support

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


alcohol

A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.


Native Americans, Federally-Recognized

biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Irritability

A proneness to anger, i.e., a tendency to become easily bothered or annoyed.


Sleep abnormality

An abnormal pattern in the quality, quantity, or characteristics of sleep.


anxiety

Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.


diacylglycerol lipase-beta

A protein that is a translation product of the human DAGLB gene or a 1:1 ortholog thereof.


macrophage

A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.


IL10 Anti-inflammatory Signaling Pathway


closed renal biopsy complications persistent pain


Unable to coordinate multiple treatment plans


New Prevention Strategies Against Disease


anterior cingulate cortex

The frontal part of the cingulate cortex that resembles a collar form around the corpus callosum. It includes both the ventral and dorsal areas of the cingulate cortex. Wikipedia:File:Gray727.svg.


gene expression

The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes.


MRI study for measuring biochemical changes in the brain


regulation of oskar mRNA translation

Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex.


Neonatal epiphyseal stippling

The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses during the neonatal period.


Morphine

A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).


neonatal abstinence syndrome

A constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors.


Allodynia

Pain due to a stimulus that does not normally provoke pain.


B8NAI7_ASPFN p38 MAPK, putative (trembl)


mast cell

A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.


Market services to healthcare professionals


Patients

biolink:Cohort biolink:StudyPopulation biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Methadone

A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.


Buprenorphine

A morphinane alkaloid that is 7,8-dihydromorphine 6-O-methyl ether in which positions 6 and 14 are joined by a -CH2CH2- bridge, one of the hydrogens of the N-methyl group is substituted by cyclopropyl, and a hydrogen at position 7 is substituted by a 2-hydroxy-3,3-dimethylbutan-2-yl group. It is highly effective for the treatment of opioid use disorder and is also increasingly being used in the treatment of chronic pain.


Severe Adverse Event

An adverse event experience that requires intensive therapeutic intervention and interrupts usual daily activities.


Pain control strategies for dressing changes


migraine disorder

A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity.


Trigeminal Ganglion/Trigeminal Nerve

A tissue sample that contains the trigeminal ganglion and branches of the trigeminal nerve.


Acute Pain

A sensation of discomfort or distress that has a severe or rapid onset.


central nervous system

The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.


Thoracic Procedure Postoperative Complication

Any disorder occurring postoperatively as a consequence of a thoracic procedure.


Pediatric Emergency Medicine - Emergency Medicine - Physicians


Hydrocodone

A morphinane-like compound that is a semi-synthetic opioid synthesized from codeine.


Oxycodone

A semisynthetic opioid of formula C18H21NO4 that is derived from thebaine.  It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain.


External causes of morbidity and mortality


A voltage-gated potassium channel KCNG2 that is encoded in the genome of human.


A voltage-gated potassium channel KCNC1 that is encoded in the genome of human.


A protein cornichon homolog 3 that is encoded in the genome of mouse.


An amyloid beta precursor protein binding family B member 2 that is encoded in the genome of human.


RGMA

A repulsive guidance molecule A that is encoded in the genome of human.


amygdala

Subcortical brain region lying anterior to the hippocampal formation in the temporal lobe and anterior to the temporal horn of the lateral ventricle in some species. It is usually subdivided into several groups. Functionally, it is not considered a unitary structure (MM).


pallidum

Part of what are called the basal ganglia of the brain which consist of the globus pallidus and the ventral pallidum.


breast

The upper ventral region of the torso of an organism.


melanoma

A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.


Dental Providers; Advanced Practice Dental Therapist


cancer

A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas.


lung

Respiration organ that develops as an outpocketing of the esophagus.


benzodiazepine

A group of heterocyclic compounds with a core structure containing a benzene ring fused to a diazepine ring.


Fentanyl

A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.


Prescription opioids (fentanyl, oxycodone [OxyContin, Percocet], hydrocodone [Vicodin], methadone, buprenorphine, etc.)


Arthroscopic shoulder procedure (procedure)


mood disorder

A cognitive disorder a disturbance in which the person's mood is hypothesized to be the main underlying feature.


female sex determination

The specification of female sex of an individual organism.


anxiety disorder

A category of psychiatric disorders which are characterized by anxious feelings or fear often accompanied by physical symptoms associated with anxiety.


infective endocarditis

Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called 'endocarditis,' although it is important to distinguish it from non-infective endocarditis. IE is caused bybacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damagethe heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue.


dura mater

Thick, fibrous meningeal covering surrounding the brain and spinal cord. It is the outermost of the three meningeal coverings. It consists of two layers: the periosteal dura linking the inner surface of the skull and the meningeal dura that lies above the arachnoid dural membrane. The meningeal layer draws away from the periosteal layer and certain locations to form the dural reflections.


A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof.


Sodium nitroprusside

A hydrate that is the dihydrate form of sodium nitroprusside.


Scoliosis, DNA analysis of 53 single nucleotide polymorphisms (SNPs), using saliva, prognostic algorithm reported as a risk score


NMDA RECEPTOR SYNAPTONUCLEAR SIGNALING AND NEURONAL MIGRATION FACTOR


Acetaminophen

A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.


Ibuprofen

A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.


geographic distribution of health care facilities


Provide education for health professionals


Back pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.


oligodendrocyte

A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.


Leukodystrophy affects various brain regions


substance abuse

The use of a drug for a reason other than which it was intended or in a manner or in quantities other than directed.


Patient suicide, attempted suicide, or self-harm that results in serious injury, while being cared for in a healthcare setting


FRACTURES OF THE NECK, TRUNK AND VERTEBRAL COLUMN


Terry White Chemists Paracetamol Colourfree Children 5-12 Years


Epidemic Disorder

The occurrence of more cases of disease than expected in a given area or among a specific group of people over a particular period of time. (CDC)


Caudal injection of opioid, postoperative


Patient-Reported Outcomes Measurement Type


opioid peptide activity

Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.


Brain imaging, positron emission tomography (PET)


behavior

The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.


caste determination, influence by genetic factors

The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects.


mu-type opioid receptor isoform h6 (human)

A mu-type opioid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35372-6.


peripheral nervous system

A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.


vasculature

An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face.


cortex

Outermost layer of an organ[WP].


Ambulatory Health Care Facilities; Clinic/Center, Military Ambulatory Procedure Visits Operational (Transportable)


Hepatobiliary neoplasms malignancy unspecified


opiate dependence

Disorders related or resulting from abuse or mis-use of opioids.


Decreased pain perception (sensory involvement)


Flare-up

A sudden worsening of a condition.


Enhanced secondary hyperalgesia and flare response on mustard oil application


Cocaine

A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.


Pimavanserin

A member of the class of ureas in which three of the four hydrogens are replaced by 4-fluorobenzyl, 1-methylpiperidin-4-yl, and 4-(isopropyloxy)benzyl groups. An atypical antipsychotic that is used (in the form of its tartrate salt) for treatment of hallucinations and delusions associated with Parkinson's disease.


Lorcaserin

A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine substituted at position 1 by a methyl group and a t position 6 by a chloro group.


Institute crisis support skills, as needed


Low back pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the lower back.


A proteinase-activated receptor 2 that is encoded in the genome of human.


NPPB

A natriuretic peptides B that is encoded in the genome of human.


An interleukin-31 receptor A that is encoded in the genome of human.


Patient age at this workup

biolink:OrganismAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


screening for opioid misuse risk assessment score high risk


sickle cell anemia

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.


A phytocannabinoid that is Delta(9)-tetrahydrocannabinol in which the methyl group at C-11 has been hydroxylated . Major metabolite of Delta(9)-tetrahydrocannabinol.


Cannabidiol

An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.


Adverse Childhood Experiences (ACE) Behavioral Risk Factor Surveillance System (BRFSS)


DRRI-2 - K: Physically Forced to Have Sex


percutaneous fixation of supracondylar humeral fracture


Naloxone

A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.


Functional Connectivity Magnetic Resonance Imaging


Monitor parental health status and health maintenance activities


psychiatric disorder

A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia.


Other pain disorders related to psychological factors


A disease caused by infection with severe acute respiratory syndrome coronavirus 2.


Alters roles to meet treatment requirements


Acknowledges consequences associated with unintended pregnancy


Past Seven Days Frequency of Pain in the Abdomen


Status of extension by tumor

biolink:ClinicalAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


preventive medicine screening for cognitive & behavioral impairment


Mindfulness Based Stress Reduction program


Mental health issue

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


post-traumatic stress disorder

An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by intrusive recurring thoughts or images of the traumatic event; avoidance of anything associated with the event; a state of hyperarousal and diminished emotional responsiveness. These symptoms are present for at least one month and the disorder is usually long-term.


Initiated episode of rehabilitation therapy, medical, or chiropractic care for neck impairment


Widespread Chronic Pain

A condition in which the nerves register normal stimuli (lack of tissue injury) as pain, resulting in feelings of intense pain with even minor sensory input.


sleep

Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.


amphetamines

Amines that constitute a class of central nervous system stimulants based on the structure of the parent amphetamine 1-phenylpropan-2-amine.


Amphetamine

A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.


Psychoactive substance use disorder, NOS


Fetal cerebellar vermis hemorrhage

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A type of fetal intracranial hemorrhage that occurs in the vermis of the cerebellum.


Butanoic acid;decanoic acid;dodecanoic acid;henicosanoic acid;heptadecanoic acid;heptanoic acid;hexadecanoic acid;hexanoic acid;icosanoic acid;nonadecanoic acid;nonanoic acid;octadecanoic acid;octanoic acid;pentadecanoic acid;pentanoic acid;tetradecanoic acid;tridecanoic acid;undecanoic acid


GM3 carbohydrate moiety

An amino trisaccharide that is the carbohydrate portion of ganglioside GM3. It comprises a linear sequence of alpha-N-acetylneuraminyl, beta-D-galactosyl and beta-D-glucose residues linked (2->3) and (1->4).


ribosome

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.


traumatic brain injury

A brain disease that is characterized by brain dysfunction caused by an outside force, usually a violent blow to the head.


Codeine

A  morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.


Black Box Warning

biolink:Activity biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Reviewed prescription drug monitoring program


Opioid Crisis

biolink:Phenomenon biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


opioid analgesic

A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.


Methamphetamine

A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.


Heroin

A morphinane alkaloid that is morphine bearing two acetyl substituents on the O-3 and O-6 positions. As with other opioids, heroin is used as both an analgesic and a recreational drug. Frequent and regular administration is associated with tolerance and physical dependence, which may develop into addiction. Its use includes treatment for acute pain, such as in severe physical trauma, myocardial infarction, post-surgical pain, and chronic pain, including end-stage cancer and other terminal illnesses.


screening for opioid misuse - risk assessment score


Abdominal pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.


Craving

The desire to experience the effect(s) of a previously used psycho-active substance. It has to be noted that not all drug craving is based on withdrawal, since craving can often occur in the absence of withdrawal.


Injection, pasireotide long acting, 1 mg


Suicidal ideation

Frequent thoughts about or preoccupation with killing oneself.


heterogeneous nuclear ribonucleoprotein D0

A protein that is a translation product of the human HNRNPD gene or a 1:1 ortholog thereof.


United States National Institutes of Health


surgical sequelae: return to operating room due to surgical complications


Mental and behavioral disorders due to use of hallucinogens, other mental and behavioral disorders


Dental pulp of third lower molar tooth

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Neonatal Opiate Withdrawal Syndrome

A constellation of neurobehavioral features observed in a neonate following cessation or reduction of postnatal exposure to opioids.


reconstruction of breast with implant prosthesis


Acellular Dermal Matrix

An allograft composed of sterile, decellularized regenerative dermal tissue matrix with soft tissue reconstructive, regenerative and transplantation purposes. The acellular dermal matrix (ADM) is composed of the dermal layer and extracellular matrix of human or animal skin and in which the epidermal layer is removed, The ADM retains native growth factors, collagen and elastin. The ADM supports tissue expanders or implants for soft tissue reconstruction or to aid in wound healing, and allows for rapid cellular proliferation and infiltration, integration of mesenchymal cells into the matrix and re-vascularization. This facilitates surgical reconstruction and protects against wound exposure and wound infection.


A transient receptor potential cation channel TRPV1 that is encoded in the genome of human.


upper intestinal tract inflammation or infection


Radiation-Protective Effect

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


inflammatory bowel disease

A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.


Utilize non-pharmacological comfort measures.


Consider pharmacological treatment, as needed


pharmacologic therapy for cessation of tobacco use assessed


admission to trauma bay secondary survey medications ordered


Phenobarbital

A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.


Benefits of cardiac rehabilitation in conjunction with pharmacologic treatment


factor IX complex, proth. complex conc. (PCC) Cb.1


Injection procedure for chemonucleolysis of multiple lumbar intervertebral discs


platelet receptor for type III collagen, human


Congenital neutropenia, myelofibrosis, nephromegaly syndrome


W0I617_CHIHA Complement component pro-C3 (trembl)


cervical disc degeneration cervicothoracic


Virtual reality (VR) procedural dissociation services provided by same health care professional performing diagnostic or therapeutic procedure VR procedural dissociation supports, additional 15 minutes


Patient Reported Outcomes Measurement Information System


PROMIS sleep disturbance - version 1.0 T-score


appendage musculature

Any collection of muscles that is part of an appendage.


Other specified intervertebral disc degeneration


Bone Marrow, Vertebral

Bone marrow in a vertebral bone.


thigh muscle fat infiltration measurement"@e


Pain intensity, Enjoyment of life, General activity scale:-:Pt:^Patient:-:Pain intensity, Enjoyment of life, General activity (PEG)


Red cell antigen phenotyping, patient red cells


Musculoskeletal Pain

Pain that originates in the bones, muscles, tendons or ligaments.


Encourage responsible decision making about lifestyle choices


Birth history

Information about the delivery and health status at birth typically elicited as a part of the past medical history.


repair of retinal detachment patient to recovery alert, oriented, stable


vagus nerve

Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart).


Purchased Services, Consulting, Clinical, Independent Peer Review


Orthocoronavirinae infectious disease

Infectious disease causes by viruses in the subfamily Orthocoronavirinae (coronaviruses). In humans, coronaviruses cause respiratory tract infections that can be mild, such as some cases of the common cold (among other possible causes, predominantly rhinoviruses), and others that can be lethal, such as SARS, MERS, and COVID-19.


Recognizes personal emotional limitations


anthrax vaccine, for intramuscular use (medication)


herpetic whitlow

A painful blister of the periungual skin that is caused by herpes simplex virus type 1 or 2.


Verbal Rating Scale pain intensity score


immune response-activating cell surface receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a cell, leading to the activation or perpetuation of an immune response.


positive regulation of adaptive immune response

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.


transcriptional regulatory protein CreB

A protein that is a translation product of the Escherichia coli K-12 creB gene or a 1:1 ortholog thereof.


masseter muscle

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by masseteric nerve branches of the trigeminal nerve (CN V), and attaches to mandible and zygomatic arch.


Nortriptyline

An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of  amitriptyline.


Ocular pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye.


Naltrexone

An  organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.


neurotrophic keratopathy

Neurotrophic keratopathy is a rare degenerative disease of the cornea characterized by reduction or loss of corneal sensitivity that can be asymptomatic or present with red-eye and, during the early stages of the disease, a minor decrease in visual acuity. It eventually leads to loss of vision.


Neuropathic Pain

Chronic pain caused by damage to nerve fibers.  It is usually associated with tissue injury.


nucleus accumbens

A region of the brain consisting of a collection of neurons located in the forebrain ventral to the caudate and putamen. (caudoputamen in rodent) and continuous with these structures. There is no distinct boundary between the nucleus accumbens and the caudate/putamen, but in rodents, it can be identified by its lack of traversing fiber bundles in comparison to the dorsal striatum. Its principle neuron is the medium spiny neuron. Together with the neostriatum (caudate nucleus and putamen), the nucleus accumbens forms the striatum.


Lumbar Puncture Headache

Headache in erect position, after lumbar puncture; due to lowering of intracranial pressure by leakage of cerebrospinal fluid through the needle tract.


A lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial that is encoded in the genome of Arabidopsis thaliana.


influenza

An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system.


Fentanyl Citrate Pectin-Based Nasal Spray


Escherichia coli heat-labile toxin antigen


Antibody-Secreting Cells

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


bone marrow

The soft tissue that fills the cavities of bones.


A0A0F9Z5B2_9BACT Acyl carrier protein, acyl carrier protein (trembl)


Any substance capable of eliciting an immune response only when attached to a large carrier such as a protein. Examples include dinitrophenols; oligosaccharides; peptides; and heavy metals.


tetanus toxoid, aluminum hydrate adsorbed


Decreased neurons in spinal sympathetic ganglia


Osteopathic manipulation, high velocity, low amplitude forces

biolink:Procedure biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Immunologic hypersensitivity

Immunological states where the immune system produces harmful responses upon reexposure to sensitising antigens.


apolipoprotein A-I-binding protein

A protein that is a translation product of the human NAXE gene or a 1:1 ortholog thereof.


Microglia

A type of glial cell that mediates immune responses by clearing cellular debris and dead neurons from nervous tissue through phagocytosis.


A0A653Q2K6_9BACL Flotillin lipid rafts scaffold protein (trembl)


TLR4-induced ripoptosome assembly (Mus musculus)

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Myeloid Cells

Cells which include the monocytes and the granulocytes.


Spinal cord injury (SCI), initial encounter


Focal acute inflammation

An inflammatory process characterized by the localized collection of polymorphonuclear neutrophils.


A6G9N6_9BACT Arachidonate 15-lipoxygenase (15-LOX) (trembl)


aurora kinase A and ninein-interacting protein

A protein that is a translation product of the human AUNIP gene or a 1:1 ortholog thereof.


Cholesterol

A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.


Vascular Endothelial Growth Factor Receptor-2


angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.


atherosclerosis

Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.


Chronic painful polyneuropathy following chemotherapy


acute lung injury

A condition of lung damage that is characterized by bilateral pulmonary infiltrates (pulmonary edema) rich in neutrophils, and in the absence of clinical heart failure. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).


A0A6G0HLX8_LARCR Potassium channel subfamily K member 18 Tresk-2 Two-pore-domain potassium channel TRESK (trembl)


trigeminal ganglion development

The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.


Headache

Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.


Patient death or serious disability due to spinal manipulative therapy


Polymeric Nanoparticle-conjugated Camptothecin DAN-222


plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.


Aprepitant

A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors.


central amygdaloid nucleus

The output region of the amygdala responsible for controlling responses (Phelps & LeDoux, 2005, http://www.ncbi.nlm.nih.gov/pubmed/ 16242399).


synaptic transmission, glutamatergic

The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


parafascicular nucleus

Part of the posterior (caudal) intralaminar group of thalamic nuclei, located medial to the centromedian nucleus and ventral to the dorsomedial nuclei, that is associated with the limbic and associative striatum.


secondary somatosensory cortex

The area of the upper bank of the lateral sulcus that is involved in somatic sensation.


Raft

biolink:PhysicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:PhysicalEssenceOrOccurrent


sphingolipid

Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.


Indomethacin

A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.


A0A5A4LKE5_TRASC Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluA1 (Fragment) (trembl)


NRCAM

A neuronal cell adhesion molecule that is encoded in the genome of human.


H7BY40_HUMAN CGRP receptor component (trembl)


Nerve injury

Injury to nervous tissue.


Operant Conditioning

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Meloxicam

A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.


methyl-CpG-binding protein 2

A protein that is a translation product of the human MECP2 gene or a 1:1 ortholog thereof.


primary somatosensory cortex

(Chapin & Lin, 1984, rat): the region considered as the SI cortex is not a cytoarchitecturally homogeneous structure but consists instead of a patchwork array of areas containing dense aggregations of layer IV granule cells, surrounded by granule-cell-sparse regions. As was shown by Welker (b71,b76), and in our own mapping studies (see Fig. 3), this discontinuous pattern of granular, or koniocortical, zones contains within itself a map of the ratbs cutaneous periphery. There are clear subtypes within this cytoarchitectural subregion, notably including the bgranular aggregateb type of cytoarchitecture characteristic of the paw, limb, and mystacial vibrissae areas, and the bbarrel-fieldb type (originally described by Woolsey and Van der Loos, b70) seen in the nose and perioral regions. In the mouse, but not the rat, such barrels also cover the whole whisker representation (Welker and Woolsey, b74).


Significant birth injury (skeletal fracture(s), peripheral nerve injury, and/or soft tissue/solid organ hemorrhage which requires intervention)


A6HCZ8_RAT Similar to Neuronal pentraxin II (NP-II) (NP2) (Neuronal activity-regulated pentraxin) (Predicted) (trembl)


tibia

The major preaxial endochondral bone in the posterior zeugopod[Phenoscape].


germinal center

A collection of activated B cells at the center of a secondary follicle, formed after B cells become activated and migrate to the center.


T Follicular Helper Cells

A subtype of antigen-experienced CD4+ T cells that are primarily found within B cell follicles near the periphery of secondary lymphoid organs and are involved in the formation and maintenance of germinal centers. These cells express CXCR5 and CD40L and secrete IL-21 and IL-4.


B cell

A lymphocyte of B lineage that is capable of B cell mediated immunity.


Ketamine

A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.


somite rostral/caudal axis specification

The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary.


mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.


postganglionic sympathetic fiber

A noradrenergic or adrenergic axonal fiber projecting from a sympathetic ganglion to an effector organ.


NEUM_CHICK Neuromodulin (sprot)

A protein that is a translation product of the GAP43 gene in chicken.


neuroma

A tumor that grows from a nerve or is composed of nerve cells and nerve fibers.


transient receptor potential cation channel TRPA

A transient receptor potential channel protein that is a member of the subfamily A of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains 14-16 copies of Ankyrin repeat (Pfam:PF00023). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means.


synaptophysin

A protein that is a translation product of the human SYP gene or a 1:1 ortholog thereof.


Q9PS46_SCYCA Neuropeptide Y, NPY=PANCREATIC polypeptide homolog (trembl)


Interneurons

A type of neuron in the central nervous system that conducts impulses between other neurons.


Gabapentin

A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.


Ketorolac

A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.


CHOP-ATF3 complex

A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits.


Ankle Injuries

Trauma to the ankle joint.


I7GDE3_MACFA Macaca fascicularis brain cDNA clone: QflA-22214, similar to human legumain (LGMN), mRNA, RefSeq: NM_005606.3 (trembl)


canine oral squamous cell carcinoma

Oral squamous cell carcinoma that occurs in a dog.


A0A1J9R3D9_9EURO CAMK/PKD protein kinase (trembl)


A C-C chemokine receptor type 2 that is encoded in the genome of mouse.


Complex regional pain syndrome I, unspecified


Q1A7A4_BOVIN Complement component C5a (Fragment) (trembl)


A0A8G0LMA4_9HYPO PTH11-type GPCRs protein (trembl)


Endosomes

A membrane bound cytoplasmic compartment that drives molecular traffic between the plasma membrane and lysosome.


Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells


Peripheral neuropathy due to and following antineoplastic therapy

Any disorder affecting the peripheral nerves resulting from exposure to chemotherapeutic agents.


A0A0B5H157_PIG IL-10 (Fragment) (trembl)


Peripheral nerve injury due to birth trauma


A0A088UF99_9BURK Protein translation initiation inhibitor (trembl)


A transient receptor potential cation channel subfamily M member 3 that is encoded in the genome of human.


Isosakuranetin

A dihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5 and 7 and a methoxy group at position 4' (the 2S stereoisomer).


Primidone

A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an  anticonvulsant for treatment of various types of seizures.


transient receptor potential cation channel TRPV4 isoform A

A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-1 or a 1:1 ortholog thereof.


trigeminal sensory nucleus

The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. The nucleus is divided into three parts, from rostral to caudal (top to bottom in humans): * The mesencephalic nucleus * The chief sensory nucleus (or pontine nucleus or main sensory nucleus or primary nucleus) * The spinal trigeminal nucleus[WP].


Structure of spinal sensory afferent system


A0A0S7IZ07_9TELE NK1R (Fragment) (trembl)


calcium-mediated signaling

Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.


complex regional pain syndrome

Complex regional pain syndrome (CRPS) is a rare neurologic disease painful progressive condition that corresponds to a group of disorders characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.


Lymphadenopathy

Enlargment (swelling) of a lymph node.


Amyloid Neuropathies

Neuropathy caused by amyloid deposition in the peripheral nerves.


fibromyalgia

A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation.


parathyroid hormone

A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof.


Mesenchymal Stromal Cells

A heterogeneous, non-hematopoietic fibroblast-like cell with the potential for differentiating into connective tissue cells of multiple lineages.  It plays a significant role in tissue repair and regeneration, and interacts with immune cells to downregulate the immune response and enable immunosuppression via the induction of tolerance.


immune system

Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies.


A6ZZE8_YEAS7 G protein coupled receptor (GPCR) (trembl)


transient receptor potential cation channel TRPA1

A transient receptor potential cation channel TRPA that is a translation product of the human TRPA1 gene or a 1:1 ortholog thereof.


terminal Schwann cell

A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse.


colitis

Inflammation of the colon.


Cytochrome P450 isoform 2B1 gene transfected human embryonic kidney 293 cells encapsulated in polymeric cellulose sulphate


A protein that is a translation product of the human IL2 gene or a 1:1 ortholog thereof. Interleukin-2 has a dual role in maintaining tolerance and contributing to immunity.


Clinical Development Plan Therapeutic Area Code


Neuroinflammation

Activation of the brain's innate immune system in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the brain.


An ATP-binding cassette sub-family G member 1 that is encoded in the genome of human.


cocaine- and amphetamine-regulated transcript protein

A protein that is a translation product of the human CARTPT gene or a 1:1 ortholog thereof.


Hemorrhage

The flow of blood from a ruptured blood vessel.


Meclofenamic acid

An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.


A methyladenosine compound with one methyl group attached to N(6) of the adenine nucleobase.


A0A8D0P7J9_PIG Adrenomedullin 2 (trembl)


Mitochondria

Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Mitochondria contain distinctive ribosomes, transfer RNAs, amino acyl t-RNA synthetases, and elongation and termination factors. Mitochondria depend upon genes within the nucleus for many essential messenger RNAs. Mitochondria consist of two sets of membranes, a smooth continuous outer coat and an inner membrane arranged in tubules or more often in folds that form platelike double membranes (cristae). Mitochondria are the principal energy source of the cell and contains the cytochrome enzymes of terminal electron transport and the enzymes of the citric acid cycle, fatty acid oxidation, and oxidative phosphorylation. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP.


A0A0D3MTH6_ONCMY Transient receptor potential vanilloid 4 (trembl)


sensory ganglion

The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells.


Decreased urocanic acid in blood, urine, and skin cells


Celecoxib

A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.


somatotropin

A somatotropin hormone family member that is a translation product of the human GH1 gene or a 1:1 ortholog thereof.


Q9PWN1_PROAN Proopiomelanocortin POMC (trembl)


cathepsin S

A cathepsin-like protease that is a translation product of the human CTSS gene or a 1:1 ortholog thereof.


oral cavity squamous cell carcinoma

A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status.


CTSS

A cathepsin S that is encoded in the genome of human.


inflammatory diarrhea

An diarrhea (disease) involving a pathogenic inflammatory response in the intestinal mucosa.


Oxidopamine

A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).


sympathetic ophthalmia

Sympathetic ophthalmia (SO) is a bilateral granulomatous anterior uveitis usually occurring within the three months following trauma or a surgical procedure involving one eye.


Nicotine

A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.


Astrocytes

A heterogeneous group of specialized neuroglial cells with many diverse supporting roles in the structure, function, and homeostasis of the central nervous system.


Norepinephrine

The R-enantiomer of noradrenaline.


Renal Epithelial Sodium Channel Inhibitors


exocytosis

A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.


Phenylpiperidine derivatives, opioid analgesics


neurotensin receptor type 1

A neurotensin receptor that is a translation product of the human NTSR1 gene or a 1:1 ortholog thereof.


A voltage-dependent R-type calcium channel subunit alpha-1E that is encoded in the genome of human.


colon carcinoma

A carcinoma that arises from epithelial cells of the colon


A protein that is a translation product of the human DNM2 gene or a 1:1 ortholog thereof.


Schwann Cells

A supporting cell of the peripheral nervous system that aids the growth, development, function, maintenance and repair of peripheral nerves. Myelinating Schwann cells form the myelin sheath around large diameter axons while non-myelinating Schwann cells bundle together portions of several unmyelinated smaller diameter axons and may also play a role in the formation and maintenance of synaptic connections in the neuromuscular junction.


Nitric Oxide

A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.


reactive oxygen species

Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.


Anti-IL-4/IL-13 Combination Agent QBX258


oxytocin-neurophysin 1

A protein that is a translation product of the human OXT gene or a 1:1 ortholog thereof.


Ritanserin

A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.


Q9GK72_LEMCA FK506-binding immunophilin FKBP51 (Fragment) (trembl)


A peptidyl-prolyl cis-trans isomerase FKBP5 that is encoded in the genome of human.


nitrotyrosine

A tyrosine derivative that is tyrosine substituted by a nitro group at unspecified position. A "closed" class.


A0A0S3QR29_LABRO Iron/manganese superoxide dismutases (Fragment) (trembl)


cerebellar nuclear complex

The gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei[MP].


Oral aversion

Reluctance or refusal of a child to be breastfed or eat, manifested as gagging, vomiting, turning head away from food, or avoidance of sensation in or around the mouth (i.e. toothbrushing or face-washing).


Tactile hypersensitivity

A decreased tolerance to physical touch.


cerebellum

Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA].


interstitial cystitis

A rare chronic debilitating urogenital disease characterized by urinary frequency, urgency, and pelvic pain.


overactive bladder

Symptom of overactive detrusor muscle of the urinary bladder that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. urinary incontinence may or may not be present.


head and neck squamous cell carcinoma

A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands.


Neoplasm of uncertain behavior of peripheral, sympathetic and parasympathetic nerves and ganglia


Propranolol

A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.


Guanethidine

A member of the class of  guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.


A protein that is a translation product of the elf1 gene in Schizosaccharomyces pombe 972h-.


brain hypoxia - ischemia

A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ischemia) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain edema; coma; and other conditions.


cerebral palsy

A group of disorders affecting the development of movement and posture, often accompanied by disturbances of sensation, perception, cognition, and behavior. It results from damage to the fetal or infant brain.


oscillatory cAMP signaling

Fluctuation in the extracellular cAMP levels due to the alternate activation of adenylate cyclase, which produces cAMP, and phosphodiesterase, which degrades it. Occurs in Dictyostelium during early sorocarp development. Oscillation in signaling result is directional chemotaxis of cells towards the center of the aggregate.


Females

biolink:OrganismAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


nervous system

The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].


skeleton

Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.


outcomes orthopedics skeletal pain alleviated


A neuropeptide Y receptor type 1 that is encoded in the genome of human.


A protein that is a translation product of the human DNM1 gene or a 1:1 ortholog thereof.


endocytosis

A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.


Pain-free intervals of days or weeks between severe headache attacks


hydromorphone-ropivacaine 3 mcg/mL-0.2% intravenous solution


A mu-type opioid receptor that is encoded in the genome of human.


Adults who are deliberately phased out of medication assisted treatment (mat) prior to 180 days of continuous treatment

biolink:Cohort biolink:StudyPopulation biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


HIV Coinfection

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Virologic Non-Response

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

The subject remains viremic during the treatment period.


Sustained Virologic Response

A finding of aviremia at a predetermined time point after the end of planned or actual treatment.


Flanker Inhibitory Control and Attention Test - computed score


BDI-2 cognitive, reasoning and academic skills - percentile


Ethnicity

biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Other or unspecified stimulant use disorder, severe


Medical care

biolink:Activity biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Preterm newborn, gestational age 34 completed weeks


Adverse Event with No Consequence or Impact

No apparent harm occurred in relation to the adverse event.


morphine / naltrexone Extended Release Oral Capsule


ALCOHOL AND/OR DRUG SERVICES; ACUTE DETOXIFICATION (HOSPITAL INPATIENT)


National Cancer Institute of Canada Clinical Trials Group


Patient Protection and Affordable Care Act


Intense psychological distress to cues

Intense or prolonged psychological distress occurs when individuals are exposed to internal or external cues that symbolize or resemble an aspect of the traumatic event or events.


behavioral health integration care management


asthma

A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.


chronic obstructive pulmonary disease

A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.


Assessment of risk for accidental opioid overdose


Severe food insecurity on United States household food security survey module


Chronic pain following surgical procedure for cancer


Addictive methamphetamine use

Addiction to methamphetamine.


biolink:ClinicalAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


Continuous/focused services: for reporting services by clinicians whose expertise is needed for the ongoing management of a chronic disease or a condition that needs to be managed and followed with no planned endpoint to the relationship; reporting clinician service examples include but are not limited to: a rheumatologist taking care of the patient's rheumatoid arthritis longitudinally but not providing general primary care services


Behavioral Health & Social Service Providers; Psychologist, Health


Self management of mental health problems


major depressive disorder

An episode of depression lasting two or more weeks without an intervening episode of mania.


Human immunodeficiency virus (HIV) coinfection


buprenorphine / naloxone Sublingual Tablet


Medication non-adherence due to psychosocial issues


Admission to inpatient rehabilitation facility


Behavioral Health Intensive Psychiatric Inpatient Unit


Global Relapse

Recurrence of disease in prior complete response or relapse in any skin, nodes, blood, or viscera category.


phytocannabinoid

A class of cannabinoid which are C21 terpenophenolic compounds isolated primarily from Cannabis sativa.


Other antibiotics for topical use in ATC


hospital discharge orders routine equipment charge


detoxification

Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


Therapeutic repetitive transcranial magnetic stimulation (TMS) treatment


Dorsolateral Prefrontal Cortex

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Referral to substance use disorder treatment program


urine

Excretion that is the output of a kidney.


Bupropion

An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.


Tremor

An unintentional, oscillating to-and-fro muscle movement about a joint axis.


Hyperhidrosis

Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather.


anorexia nervosa

A disorder most often seen in adolescent females characterized by a refusal to maintain a minimally normal body weight, an intense fear of gaining weight, a disturbance in body image, and, in postmenarcheal females, the development of amenorrhea.


COS Cells

The line was derived from the CV-1 cell line (ATCC CCL-70) by transformation with an origin defective mutant of SV40 which codes for wild type T antigen. The cells contain a single integrated copy of the complete early region of the SV40 genome.


Tobacco, Alcohol, Prescription medications, and other Substance use screen:-:12Mo:^Patient:-:TAPS


Luminopia Digital Therapeutic Software for Pediatric Amblyopia


Biological Neural Networks

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Electronic health record (EHR) or component of EHR


Asthma, chronic obstructive pulmonary disease (COPD), or chronic lung disease (e.g., chronic bronchitis and restrictive lung diseases such as asbestosis)


Behavioral &or mental health screen assessment


male sex determination

The specification of male sex of an individual organism.


Pointed chin (more apparent at older ages)


Neonatal infections (excl congenital infections)


intervention and management services covered by infectious disease


Treatment Satisfaction Questionnaire for Medication


interventional services emergency department


Nausea

A sensation of unease in the stomach together with an urge to vomit.


Vomiting

Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.


post-operative care patient discharge assessment performed


bipolar II disorder

A bipolar disorder that is characterized by at least one hypomanic episode and at least one major depressive episode; with this disorder, depressive episodes are more frequent and more intense than manic episodes.


Adults currently taking pharmacotherapy for oud


PhenX measure - posttraumatic stress disorder (PTSD)


Blood pressure recorded during inpatient stays, emergency room visits, or urgent care visits


cocaine dependence

A psychologically and socially impaired state, with or without physiological changes, that develops as a result of using cocaine and which leads to compulsive behaviors to acquire the substance.


Non-Fatal Cardiopulmonary Arrest Cause Unknown, CTCAE


polysubstance drug use (indiscriminate drug use)


Extension for Community Healthcare Outcomes


A0A8C5F2J5_9SAUR Mu opioid receptor (trembl)


opioid abuse

A substance abuse that involves the recurring use of opioid drugs despite negative consequences.


ATP-binding cassette sub-family B member 5

A protein that is a translation product of the human ABCB5 gene or a 1:1 ortholog thereof.


mu-type opioid receptor

An opioid receptor protein that is a translation product of the human OPRM1 gene or a 1:1 ortholog thereof. The preferred ligands are beta-endorphin and enkephalins.


Hypercapnia

Abnormally elevated blood carbon dioxide (CO2) level.


Sensorimotor Cortex

The region of the brain that consists of the precentral and postcentral gyri and is involved in somatosensory and motor functions.


Thalamic/Basal Ganglia

The anatomic location of the thalamus and basal ganglia.


memory

The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).


N-methyl-D-aspartate Receptor Antagonist [EPC]


Hydrogen Bonds

biolink:Phenomenon biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Q716A7_HUMAN Mu opioid receptor MOR-1O (Fragment) (trembl)


W6RD20_9HYPH Soluble epoxide hydrolase SEH (trembl)


epoxy fatty acid

A heterocyclic fatty acid containing an epoxide ring as part of its structure.


5,15-disubstituted porphyrin

A porphyrin compound substituted on opposing methine groups of the porphyrin ring.


A0A1J9RIH3_9PEZI G-protein coupled g-protein-coupled (trembl)


A mu-type opioid receptor that is encoded in the genome of mouse.


analgesic

An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.


Sufentanil

An anilide resulting from the formal condensation of the aryl amino group of 4-(methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid.


Hypoventilation

A reduction in the amount of air transported into the pulmonary alveoli by breathing, leading to hypercapnia (increase in the partial pressure of carbon dioxide).


cellular senescence

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.


GNP Glucose 15g Liquid Shot (Mixed Berry)


indole alkaloid

An alkaloid containing an indole skeleton.


ligand

Any molecule or ion capable of binding to a central metal atom to form coordination complexes.


Stavudine

A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase


ventral anterior nucleus of thalamus

The ventral anterior nucleus is a nucleus of the thalamus.


dorsolateral prefrontal cortex

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The dorsolateral prefrontal cortex (DL-PFC or DLPFC), according to a more restricted definition, is roughly equivalent to Brodmann areas 9 and 46.[1] According to a broader definition DL-PFC consists of the lateral portions of Brodmann areas 9 - 12, of areas 45, 46, and the superior part of area 47.[2] These regions mainly receive their blood supply from the middle cerebral artery. With respect to neurotransmitter systems, there is evidence that dopamine plays a particularly important role in DL-PFC.[2]DL-PFC is connected to the orbitofrontal cortex, and to a variety of brain areas, which include the thalamus, parts of the basal ganglia (the dorsal caudate nucleus), the hippocampus, and primary and secondary association areas of neocortex, including posterior temporal, parietal, and occipital areas.


premotor cortex

The premotor cortex is an area of motor cortex lying within the frontal lobe of the brain. It extends 3 mm anterior to the primary motor cortex, near the Sylvian fissure, before narrowing to approximately 1 mm near the medial longitudinal fissure, which serves as the posterior border for the prefrontal cortex. The premotor cortex is largely equivalent to Brodmann area 6. Activity within this region is critical to the sensory guidance of movement and control of proximal and trunk muscles of the body.


Decreased heart rate variability

Reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle.


Shakes

Unsteadiness or trembling movements of the whole body or a body part.


Cognitive behavioral therapy for insomnia


Flat Affect

The absence of emotional expressiveness.


brain

The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].


A0A8C0QCE6_CANLF Opioid related nociceptin receptor 1 (trembl)


Alpha-adrenoreceptor antagonists, peripherally acting


opioid-induced constipation

A constipation disorder caused by use of opiods. OIC may present immediately when a patient takes the opioid, or it may present gradually during opioid therapy.


Gastrointestinal tract mucosal discoloration


Deafness, encephaloneuropathy, obesity, valvulopathy syndrome


HEK293 Cells

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Hapten

A substance that can act as an epitope for an antibody but that lacks immunogenicity unless coupled to a larger carrier molecule.


Carfentanil

A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of methyl 4-anilino-1-(2-phenylethyl)piperidine-4-carboxylate with propanoic acid.


PAPILLOMAVIRUS HUMAN QUADRIVALENT VACCINE


O77674_RABIT 5-HT2a receptor (Fragment) (trembl)


Bradycardia

A slower than normal heart rate (in adults, slower than 60 beats per minute).


Polysomnography

biolink:Procedure biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Central sleep apnea, Idiopathic central sleep apnea


Liraglutide

A lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.


Suvorexant

An aromatic amide obtained by formal condensation of the carboxy group of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid with the secondary amino group of 5-chloro-2-[(5R)-5-methyl-1,4-diazepan-1-yl]-1,3-benzoxazole. An orexin receptor antagonist used for the management of insomnia.


orexin/hypocretin receptor type 1

An orexin receptor that is a translation product of the human HCRTR1 gene or a 1:1 ortholog thereof.


Benzyl Alcohol

An aromatic alcohol that consists of benzene bearing a single hydroxymethyl substituent.


A regulator of G-protein signaling 4 that is encoded in the genome of human.


A regulator of G-protein signaling 9 that is encoded in the genome of mouse.


Microsomes, Liver

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Karyocytomegaly and Multinucleated Hepatocytes

A finding of both karyocytomegaly and multinucleated hepatocytes in the same lesion.


Transcutaneous stimulation of cervical branch of vagus nerve


Distress

A state of physiological or psychological stress that cannot be compensated for by normal adaptive measures.


pain reprocessing by transcutaneous electrical modulation


leptin

A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof.


Pelvic Floor Muscle Weakness, CTCAE

A disorder characterized by a reduction in the strength of the muscles of the pelvic floor.


Chronic Prostatitis with Chronic Pelvic Pain Syndrome


Pelvic pain

Pain perceived in the area of the pelvis, the lower part of the abdomen located between the hip bones.


hospitalization length of stay (___ days)


Jaundice

Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.


Serotonin

A primary amino compound that is the 5-hydroxy derivative of tryptamine.


Hypometabolism of the frontal lobe and thalamic regions


Orthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Proximal, Therapeutic, Dynamic Splint


Subcortical

Denoting the area below a cortex.


end stage renal failure

Long-standing and persistent renal disease with glomerular filtration rate (GFR) less than 15 ml/min.


chronic kidney disease

Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.


Chronic kidney disease stage 5 on dialysis


Conservative management of chronic kidney disease (CKD)


endometriosis

The growth of functional endometrial tissue in anatomic sites outside the uterine body. It most often occurs in the pelvic organs.


lumbosacral postural maneuvers centralized pain


Opioid therapy for breathlessness management


Other unknown and unspecified cause of morbidity and mortality


Pre-Exposure Prophylaxis and Post-Exposure Prophylaxis


Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE


opioid use with specified opioid-induced disorder


Products Used to Treat Thrombocytopenic Purpura


Enrollment in medication assistance program


previous hospitalization for drug overdose


Antibody Interactions

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Surveillance of immunization status in group living facilities (e.g., jails, group homes)


contact with recently incarcerated persons


Oxyquinoline Sulfate/Zinc Oxide Topical application Ointment [GOOD SAMARITAN HEALING OINTMENT]


Injection Site

The anatomic site at which a medication or a vaccine is injected.


Cell Phone Use

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Internet

biolink:PhysicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:PhysicalEssenceOrOccurrent


Transcutaneous auricular neurostimulation, set-up, calibration, and patient education on use of equipment


A0A0J9X628_GEOCN Similar to Saccharomyces cerevisiae YOR299W BUD7 Member of the ChAPs family of proteins that forms the exomer complex to mediate export of specific cargo proteins from the Golgi to the plasma membrane (trembl)


A0A1C9ZQF2_CYNPY T-type calcium channel (Fragment) (trembl)


Mesenchymal Stem Cells

An undifferentiated stromal cell with the ability to develop into the cells that form distinct mesenchymal tissues; such as bone, muscle, connective tissue, blood vessels, and lymphatic tissue.


hyaline cartilage tissue

Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.


A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group.


ribonuclease P protein subunit p38

A protein that is a translation product of the human RPP38 gene or a 1:1 ortholog thereof.


A runt-related transcription factor 2 that is encoded in the genome of human.


Acute exacerbation of chronic abdominal pain


A0A077KE37_9FLAO RNA polymerase sigma-Z factor (trembl)


Lidocaine

The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.


primary dorsal nerve cord

A nerve cord in the dorsal mid-line that is the most prominent nerve cord.


graphene oxide

A single carbon layer of the graphite oxide structure.


BMP signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


A0A068WIZ4_ECHGR High voltage activated calcium channel beta (trembl)


Stem cells

An unspecialized cell that has the capacity for reproduction through cell division and can be induced to differentiate into a tissue or organ specific cell.


eukaryotic translation initiation factor 5A


Certified health education specialist

biolink:Cohort biolink:StudyPopulation biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Signs and symptoms of depression

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Psychiatric or mood diseases or conditions

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Other placental conditions, affecting management of mother, antepartum condition or complication


Other Service Providers; Peer Specialist


Health Services, University

biolink:Activity biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels


neuralgia

A pain disorder characterize by pain in the distribution of a nerve or nerves


RCADS (Revised Children's Anxiety and Depression Scale) total anxiety and depression score


A Mas-related G-protein coupled receptor X1 that is encoded in the genome of human.


post-traumatic stress disorder with dissociative symptoms


Physiological regions of airflow, upper airway


Central apnea

Apnea resulting from depression of the respiratory centers in the medulla oblongata. There is a lack of respiratory effort rather than obstruction of airflow.


Upper airway obstruction

Increased resistance to the passage of air in the upper airway.


obstructive sleep apnea syndrome

Cessation of air flow during sleep due to upper airway obstruction.


Compliance of last 20% of breath/Compliance of entire breath | Respiratory system | Respiratory measures and Ventilator management


Oxygen Consumption

biolink:ClinicalAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


Activity metabolic rate/Predicted resting metabolic rate


Acupuncture needles disposable each item


Acupuncture Points

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An anatomic point, as defined by the Standard Acupuncture Nomenclature, that can be stimulated via various techniques, including the insertion and withdrawal of needles, the application of heat, massage, laser, electrical pulsation, or a combination of these methods.


settings for transcutaneous electrical nerve stimulation (TENS)


ventral striatum

A composite structure of the telencephalon that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the anterior perforated substance, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance (Heimer-1995; adapted from Brain Info).


Pain Relief

A lessening of pain following an intervention.


Analyzers, Point-of-Care, Urine, Toxicology Screening


visit for repeat prescription for medication


Impaired ability to shift attention

A behavioral abnormality whereby a person is unable to move freely from one situation, activity or aspect of aa problem to another as circumstances demand. Key aspects of shifting include the ability to make transitions, problem solve flexibly, switch or alternate attention, and change focus from one mind-set or topic to another. Mild deficits in the ability to shift compromise the efficiency of problem solving, whereas more severe difficulties are reflected in perseverative behaviors. Sometimes this is described as being rigid or inflexible.


high-risk youth

biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Problem, related to marijuana use, that occurred for more than 24H to the point that it interfered with functioning or relationships


Crisis/short term interventions in mental health care


Victimization

biolink:Phenomenon biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


child protective services referral to parenting resources


Teach patient to obtain midstream urine specimens at first sign of return of symptoms, as appropriate


Externalizing Disorder Symptoms

Impulsive, disruptive, or aggressive behaviors that typically emerge in childhood or early adolescence and are associated with significant functional impairment. Child and adolescent externalizing disorders include conduct disorder, oppositional defiant disorder, and attention-deficit/hyperactivity disorder.


Adjustment disorder with mixed anxiety and depressed mood


ADHD, predominantly hyperactive - impulsive


PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS


office-based treatment for opioid use disorder


Referral to fair housing assistance program


Sex assigned at birth

biolink:OrganismAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


drug use continues despite social consequences


Perceptual distortions as consequence of immobility


Computed Spanish/Hispanic Ethnicity Code


autism spectrum disorder

A spectrum of developmental disorders that includes autism, and Asperger syndrome. Signs and symptoms include poor communication skills, defective social interactions, and repetitive behaviors.


Tobacco, Alcohol, Prescription medications, and other Substance use screen


Analgesics and non-steroidal anti-inflammatory drugs


Non-physician (e.g. nurse practitioner (np), certified registered nurse anesthetist (crna), certified registered nurse (crn), clinical nurse specialist (cns), physician assistant (pa)) services in a critical access hospital


temporomandibular joint disorder

Any condition affecting the anatomic and functional characteristics of the temporomandibular joint.


Conditions related to intellectual disability and developmental disability status


Moving jaw

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


nac

A GDP-fucose transporter 1 that is encoded in the genome of fruit fly.


sleep disorder

A change from the patient's baseline sleeping pattern, in the hours slept and/or an alteration/dysfunction in the stages of sleep.


Hydroxyzine

A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.


Worried about health interfering with sleep before illness