A C-C chemokine receptor type 7 that is encoded in the genome of human.


osteoarthritis

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A noninflammatory degenerative joint disease occurring chiefly in older persons, characterized by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.


Joint Involvement

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A finding indicating the spread of cancer to a joint.


cartilage tissue

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.


subchondral region of epiphysis

The bone region of the epiphysis that provides underlying mechanical and physiological support for the cartilage of joint articular surfaces.


capsaicinoid

A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.


Cryocuff treatment

biolink:Procedure biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Set of peripheral nerves

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Nociceptive Stimulus

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Inflammatory cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


aggrecan core protein

A protein that is a translation product of the human ACAN gene or a 1:1 ortholog thereof.


ADAMTS-like protein 4

A protein that is a translation product of the human ADAMTSL4 gene or a 1:1 ortholog thereof.


ADAMTS-like protein 5

A protein that is a translation product of the human ADAMTSL5 gene or a 1:1 ortholog thereof.


membrane-type 1 matrix metalloproteinase


sensory neuron of dorsal root ganglion

A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord.


A C-C motif chemokine 2 that is encoded in the genome of human.


A Toll-like receptor 2 that is encoded in the genome of mouse.


Autologous CD8+ SLC45A2-specific T Lymphocytes

A preparation of autologous CD8+ T lymphocytes targeting SLC45A2, a melanoma-associated antigen, with potential immunomodulating and antineoplastic activities. Following peripheral blood mononuclear cell (PBMC) collection and ex vivo expansion of SLC45A2-specific cytotoxic T-lymphocytes (CTLs), the autologous CD8+ SLC45A2-specific CTLs are re-infused into the patient, where they target and lyse SLC45A2-expressing tumor cells. While SLC45A2 is expressed by approximately 80% of cutaneous melanomas, its expression is limited in mature normal melanocytes, allowing high tumor selectivity and reduced potential for autoimmune toxicity.


A ubiquitin carboxyl-terminal hydrolase isozyme L1 that is encoded in the genome of human.


bone marrow cavity

The medullary cavities of the bones where bone marrow is stored.


pain receptor cell

The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings.


nociceptor nerve ending

A peripheral terminal of a peripheral, afferent sensory pain receptor cell that is sensitive to injury or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. The nociceptor nerve ending innervates target tissue and transduces noxious stimuli to the central nervous system via some axon(s).


Innate Lymphoid Cell

Innate immune cells in the lymphoid lineage that do not express recombination-activating genes (RAGs), T-cell or B-cell receptors, or any myeloid or dendritic cell markers. There are several subtypes of innate lymphoid cells (ILC): group 1 ILC express TBX21 and Th1 cytokines, group 2 ILC produce type 2 cytokines, group 3 ILC produce interleukin-17A (IL-17A) and/or IL-22 and lymphoid tissue inducer cells (LTi cells) do not express CD3 but do express IL-7, CD45, CD4 and a large number of additional markers.


mucosal type mast cell

Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype.


Afferent neuron

An afferent neuron that converts environmental stimuli into electrical impulses that are transmitted to the central nervous system.


osteoarthritis susceptibility 1

Any osteoarthritis in which the cause of the disease is a mutation in the FRZB gene.


Pain

An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.


Chronic musculoskeletal pain due to persistent inflammation


NGF

A beta-nerve growth factor that is encoded in the genome of human.


A developmentally-regulated GTP-binding protein 1 that is encoded in the genome of mouse.


F4/80-positive adipose macrophage

An adipose macrophage that does not express MHC-II but is F4/80-positive.


A protein that is a translation product of the PERK1 gene in Arabidopsis thaliana.


A Toll-like receptor 4 that is encoded in the genome of human.


A myeloid differentiation primary response protein MyD88 that is encoded in the genome of human.


A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof.


Chronic painful polyneuropathy following chemotherapy


A protein Wnt-10a that is encoded in the genome of mouse.


dorsal root ganglion

Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain. (MSH) * ganglion found on the posterior root of each spinal nerve, composed of the unipolar nerve cell bodies of the sensory neurons of the nerve. (CSP).


A transient receptor potential cation channel TRPV1 that is encoded in the genome of rat.


sodium channel protein type 7 subunit alpha

A voltage-gated sodium channel subunit alpha that is a translation product of the human SCN7A gene or a 1:1 ortholog thereof.


spinal cord

Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).


A cysteinyl leukotriene receptor 2 that is encoded in the genome of mouse.


leukotriene D4

A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).


dermatitis

An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis.


Neural Pathways

The route in which a nerve impulse travels through a series of linked axons to connect different regions within the central nervous system or to convey information from the peripheral nervous system to the brain.


Neurons

Any of the conducting cells of the nervous system. A typical neuron consists of a cell body, containing the nucleus and the surrounding cytoplasm (perikaryon); several short radiating processes (dendrites); and one long process (the axon), which terminates in twiglike branches (telodendrons) and may have branches (collaterals) projecting along its course.


innate immune response

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.


Neuropathic Pain

Chronic pain caused by damage to nerve fibers.  It is usually associated with tissue injury.


dorsal horn of spinal cord

The pronounced, dorsolaterally oriented ridge of grey matter in each lateral half of the spinal cord[MP]. the dorsal (more towards the back) grey matter of the spinal cord. It receives several types of sensory information from the body, including light touch, proprioception, and vibration. This information is sent from receptors of the skin, bones, and joints through sensory neurons whose cell bodies lie in the dorsal root ganglion[WP]. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input[GO].


macrophage

A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.


Inflammation

A finding of a localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation.


Chronic pain

Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months.


chronic pain syndrome

Chronic form of disorder involving pain.


An anthrax toxin receptor 2 that is encoded in the genome of human.


fan Martinotti neuron

A Martinotti neuron that has axons that form a fan-like plexus.


An opsin-5 that is encoded in the genome of mouse.


Spontaneous cortical electrical activity

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


neurological pain disorder

A nervous system disorder that has pain as a major feature.


type 2 diabetes mellitus

A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.


synovitis

Inflammation of a synovial membrane.


obesity disorder

A disorder involving an excessive amount of body fat.


Cannabidiol

An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.


NADPH--cytochrome P450 reductase

A protein that is a translation product of the human POR gene or a 1:1 ortholog thereof.


mature microglial cell

A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation.


Stress

The negative mental, emotional, and physical reactions that occur when environmental stressors are perceived as exceeding the individual's adaptive capacities.


Social support

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


alcohol

A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.


Irritability

A proneness to anger, i.e., a tendency to become easily bothered or annoyed.


Declarative memory loss

Impaired ability to remember facts and events.


Sleep abnormality

An abnormal pattern in the quality, quantity, or characteristics of sleep.


mood disorder

A cognitive disorder a disturbance in which the person's mood is hypothesized to be the main underlying feature.


diacylglycerol lipase-beta

A protein that is a translation product of the human DAGLB gene or a 1:1 ortholog thereof.


Cocaine use, unspecified with unspecified cocaine-induced disorder


anterior cingulate cortex

The frontal part of the cingulate cortex that resembles a collar form around the corpus callosum. It includes both the ventral and dorsal areas of the cingulate cortex. Wikipedia:File:Gray727.svg.


Ammon's horn

A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum.


analgesic

An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.


buprenorphine hydrochloride + naloxone hydrochloride


Morphine

A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).


neonatal abstinence syndrome

A constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors.


Allodynia

Pain due to a stimulus that does not normally provoke pain.


mitogen-activated protein kinase 8 phosphorylated 1

A mitogen-activated protein kinase 8 phosphorylated form in which the phosphorylation occurs at the TxY motif that activates the MAP kinases.


mast cell

A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.


Health Professional

biolink:Cohort biolink:StudyPopulation biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Educational Activities

biolink:Activity biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Dextromethadone

A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder.


Variation (Genetics)

biolink:Phenomenon biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


proteinase-activated receptor 2

A proteinase-activated receptor that is a translation product of the human F2RL1 gene or a 1:1 ortholog thereof. It is activated by trypsin and trypsin-like proteinases, which cleave the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity.


migraine disorder

A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity.


trigeminal nerve

Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw).


Bone Marrow-Derived Fibroblasts

A biological sample containing fibroblasts isolated from the bone marrow of an experimental subject.


compound 48/80

R1, R2 = H or CH2OH; n is normally between 1 and 10. An alternating copolymer resulting from the condensation of N,O-dimethyltyramine with formaldehyde. It is a potent histamine releasing agent, primarily from mast cells, with subsequent depletion of tissue histamine.


chiropractic manipulative treatment (CMT) of spine


lysophospholipid (S1P) receptor

An LPAR1/S1PR1-like lysophospholipid receptor that is a translation product of the human S1PR1, S1PR2, S1PR3, S1PR4, or S1PR5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues.


central nervous system

The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.


A mu-type opioid receptor that is encoded in the genome of human.


A delta-type opioid receptor that is encoded in the genome of mouse.


A D(2) dopamine receptor that is encoded in the genome of human.


Bdnf

A brain-derived neurotrophic factor that is encoded in the genome of mouse.


A voltage-gated potassium channel KCNG2 that is encoded in the genome of human.


A voltage-gated potassium channel KCNC1 that is encoded in the genome of human.


A protein cornichon homolog 3 that is encoded in the genome of mouse.


An amyloid beta precursor protein binding family B member 2 that is encoded in the genome of human.


Rgma

A repulsive guidance molecule A that is encoded in the genome of mouse.


hemisphere part of cerebellar anterior lobe

A multi-tissue structure that is part of a anterior lobe of cerebellum and is part of a cerebellar hemisphere.


pallidum

Part of what are called the basal ganglia of the brain which consist of the globus pallidus and the ventral pallidum.


breast

The upper ventral region of the torso of an organism.


melanoma

A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.


Pregnant Women

biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


cancer

A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas.


lung

Respiration organ that develops as an outpocketing of the esophagus.


Drug Overdose

Exposure to, or intake of, an excessive amount of a substance.


L-phenylalanine derivative

A proteinogenic amino acid derivative resulting from reaction of L-phenylalanine  at the amino group or the carboxy group, or from the replacement of any hydrogen of L-phenylalanine  by a heteroatom.


Arthroscopy, shoulder, diagnostic, with or without synovial biopsy (separate procedure)


alcohol dependence

Physical and psychological dependence on alcohol.


anxiety disorder

A category of psychiatric disorders which are characterized by anxious feelings or fear often accompanied by physical symptoms associated with anxiety.


infective endocarditis

Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called 'endocarditis,' although it is important to distinguish it from non-infective endocarditis. IE is caused bybacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damagethe heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue.


dura mater

Thick, fibrous meningeal covering surrounding the brain and spinal cord. It is the outermost of the three meningeal coverings. It consists of two layers: the periosteal dura linking the inner surface of the skull and the meningeal dura that lies above the arachnoid dural membrane. The meningeal layer draws away from the periosteal layer and certain locations to form the dural reflections.


transmission of nerve impulse

The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.


substance abuse

The use of a drug for a reason other than which it was intended or in a manner or in quantities other than directed.


Back pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.


oligodendrocyte

A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.


myelin assembly

The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.


Inappropriate attention seeking behavior


Postoperative administration of analgesia


G protein-coupled opioid receptor activity

Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein.


Chronic arthralgia of temporomandibular joint


COMT (catechol-O-methyltransferase) (eg, drug metabolism) gene analysis, c.472G>A (rs4680) variant


Post-Operative Pain

A sensation of discomfort secondary to surgery.


brain

The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].


mu-type opioid receptor

An opioid receptor protein that is a translation product of the human OPRM1 gene or a 1:1 ortholog thereof. The preferred ligands are beta-endorphin and enkephalins.


Carfentanil

A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of methyl 4-anilino-1-(2-phenylethyl)piperidine-4-carboxylate with propanoic acid.


peripheral nervous system

A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.


cortex

Outermost layer of an organ[WP].


delta-type opioid receptor

An opioid receptor protein that is a translation product of the human OPRD1 gene or a 1:1 ortholog thereof. The preferred ligands are enkephalins.


Acute Pain

A sensation of discomfort or distress that has a severe or rapid onset.


Malignant hepatobiliary neoplasms

A malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder.  Representative examples include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


opioid abuse

A substance abuse that involves the recurring use of opioid drugs despite negative consequences.


Self-initiation skills

biolink:ClinicalAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


Low back pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the lower back.


A proteinase-activated receptor 2 that is encoded in the genome of mouse.


Nppb

A natriuretic peptides B that is encoded in the genome of mouse.


An interleukin-31 receptor A that is encoded in the genome of human.


patient is female

biolink:OrganismAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


percutaneous fixation of supracondylar humeral fracture


Core build-up, including any pins when required


Abnormal brain morphology

A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain.


mental disorder

A disease that has its basis in the disruption of mental process.


Education about safe disposal of medication


Unintended Movement Medical Device Problem


response to pheromone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.


Severity of pain on average over the past Mo


RNAx manage patient expectations of pain relief


Compound muscle action potential amplitude facilitation

Compound muscle action potential amplitude (CMAP) facilitation denotes an increase in tendon reflexes, strength, or CMAP amplitude after 10 seconds of maximal voluntary contraction.


post-traumatic stress disorder

An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by intrusive recurring thoughts or images of the traumatic event; avoidance of anything associated with the event; a state of hyperarousal and diminished emotional responsiveness. These symptoms are present for at least one month and the disorder is usually long-term.


Meditation-Based Stress Reduction Program


musculoskeletal system disorder

A disease involving the musculoskeletal system.


sleep

Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.


amphetamines

Amines that constitute a class of central nervous system stimulants based on the structure of the parent amphetamine 1-phenylpropan-2-amine.


cerebellar vermis

A subregion of the cerebellar cortex, consisting of the most medial zone of the cerebellar cortex, stradding the midline. May be continuous with the lateral cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissures in others (e.g., ventrally).


oxylipin

Any member of the group of bioactive lipids made by oxidation of polyunsaturated fatty acids.


epoxide

Any cyclic ether in which the oxygen atom forms part of a 3-membered ring.


A proteinase-activated receptor 3 that is encoded in the genome of mouse.


Progesterone receptor agonist-containing product


Ribosomes

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Ribosomes are small organelles composed of ribosomal RNA (rRNA) and 80 some different proteins. rRNA is synthesized in the nucleolus and the ribosomal subunits are assembled there from rRNA and imported cytoplasmic made proteins. Once assembled, the subunits pass through the nuclear pores to the cytoplasm where they take part in protein synthesis. Some ribosomes are free in the cytoplasm and can be recruited to a polyribosomal structure when a messenger RNA (mRNA) strand is to be translated into a cytoplasmic protein. Other ribosomes are attached to the endoplasmic reticulum where the protein is formed within the interior to the endoplasmic reticulum. These proteins are destined for secretion, storage or incorporation into membranes.


GNAS gene translation product

A protein that is a translation product of the human GNAS gene or a 1:1 ortholog thereof.


Traumatic AND/OR non-traumatic brain injury

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


United States Food and Drug Administration


Codeine

A  morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.


temporomandibular joint dysfunction syndrome

A common disorder noted with jaw movement. It may be caused by malocclusion, repetitive use injury, trauma or arthritis. It is more prevalent among females between their second and fourth decades. Clinical signs include preauricular pain, temporomandibular joint clicking (as the mandibular condyle slips from the articulation made with the capsular disk and temporal bone) and restriction of jaw motion. Clinical course is typically benign but may progress to associated headaches, ear and neck pain, tinnitus and dislocation of temporomandibular joint. Prognosis is favorable as a majority of cases will respond to conservative management.


Masseter Muscle Spasm

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Admitted as an inpatient:Find:Pt:^Patient:Ord


services source emergency medical services (ambulance)


Abdominal pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.


Physical addiction

The neuroadaptation of the body to the presence of an opioid, and is characterized by the onset of acute symptoms and signs of withdrawal if the opioid is stopped or an opioid antagonist is administered.


Blood Pressure Finding

A test result that reports the diastolic and systolic pressure of the blood.


luciferase-like monooxygenase

A protein that is a translation product of the Escherichia coli K-12 yhbW gene or a 1:1 ortholog thereof.


An X-ray repair cross-complementing protein 6 that is encoded in the genome of human.


Heterogeneous Nuclear Ribonucleoprotein D0


United States National Institutes of Health


United States Department of Veterans Affairs


psychiatric disorder

A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia.


cardiovascular disorder

A disease involving the cardiovascular system.


Cardiopulmonary bypass average flow rate


maternal condition complicating pregnancy, childbirth, and puerperium


opioid analgesic

A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.


Neonatal Opiate Withdrawal Syndrome

A constellation of neurobehavioral features observed in a neonate following cessation or reduction of postnatal exposure to opioids.


Structure of posterior thalamic radiation of internal capsule


reconstruction of breast with implant prosthesis


Curare alkaloid muscle relaxants, peripherally acting


Acellular Dermal Matrix

An allograft composed of sterile, decellularized regenerative dermal tissue matrix with soft tissue reconstructive, regenerative and transplantation purposes. The acellular dermal matrix (ADM) is composed of the dermal layer and extracellular matrix of human or animal skin and in which the epidermal layer is removed, The ADM retains native growth factors, collagen and elastin. The ADM supports tissue expanders or implants for soft tissue reconstruction or to aid in wound healing, and allows for rapid cellular proliferation and infiltration, integration of mesenchymal cells into the matrix and re-vascularization. This facilitates surgical reconstruction and protects against wound exposure and wound infection.


enteritis

Inflammation of the small intestine.


Pain insensitivity

Inability to perceive painful stimuli.


inflammatory bowel disease

A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.


neutrophil elastase

A trypsin that is a translation product of the human ELANE gene or a 1:1 ortholog thereof.


Homeopathic non-liquid remedy preparation each 5 minutes


Second or subsequent drug of a multiple drug unit dose formulation


Neurodevelopmental delay

Neurodevelopmental delay (NDD) refers to delays in the maturation of the brain and central nervous system; infants and young children with NDD may experience delays in the development of one or more skills including gross motor abilities, fine-motor coordination, language abilities and ability to solve increasingly complex problems.


protein CbrA

A protein that is a translation product of the Escherichia coli K-12 cbrA gene or a 1:1 ortholog thereof.


magnetic resonance spectroscopic imaging


bone marrow failure syndrome

A familial or acquired bone marrow failure syndrome.


A protein that is a translation product of the C4b gene in mouse.


Creating Optimum Health Through MindBodySpirit Integration(TM) (COHMI) Level II each program


BMF

A Bcl-2-modifying factor that is encoded in the genome of human.


PROMIS Parent Proxy Short Form - Pain Interference


PROMIS-29 questionnaire sleep disturbance


Congenital musculoskeletal deformities of spine


ventral midline

In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate.


intervertebral disk degenerative disorder

Any disease of a degenerative nature that affects the intervertebral disk.


vertebral column disorder

A disease involving the vertebral column.


Musculoskeletal Pain

Pain that originates in the bones, muscles, tendons or ligaments.


Metabolic Response

An evaluation of the metabolic response of the disease to the therapy.


Birth history

Information about the delivery and health status at birth typically elicited as a part of the past medical history.


Adultcare center provider, perpetrator of maltreatment and neglect


intervention using behavioral activation


vagus nerve

Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart).


Daily therapeutic intervention scoring system score


Cognitive behavioral therapy for psychosis


anticipatory guidance: stimulation - peer refusal skills


immune response-regulating cell surface receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.


immune organ

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An organ that is part of a immune system [Automatically generated definition].


A signal transducer and activator of transcription 3 that is encoded in the genome of mouse.


transcriptional regulatory protein CreB

A protein that is a translation product of the Escherichia coli K-12 creB gene or a 1:1 ortholog thereof.


central motor evoked potential

biolink:Procedure biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


masseter muscle

Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by masseteric nerve branches of the trigeminal nerve (CN V), and attaches to mandible and zygomatic arch.


Ocular pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye.


Headache

Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.


Stomach Cramp

An involuntary muscular contraction in the stomach. Often, this cramp is spasmodic and can be uncomfortable.


neurotrophic keratopathy

Neurotrophic keratopathy is a rare degenerative disease of the cornea characterized by reduction or loss of corneal sensitivity that can be asymptomatic or present with red-eye and, during the early stages of the disease, a minor decrease in visual acuity. It eventually leads to loss of vision.


Nerve injury

Injury to nervous tissue.


Symptom

Subjective evidence of disease perceived by the patient.


A protein that is a translation product of the human IL18 gene or a 1:1 ortholog thereof.


nucleus accumbens

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A region of the brain consisting of a collection of neurons located in the forebrain ventral to the caudate and putamen. (caudoputamen in rodent) and continuous with these structures. There is no distinct boundary between the nucleus accumbens and the caudate/putamen, but in rodents, it can be identified by its lack of traversing fiber bundles in comparison to the dorsal striatum. Its principle neuron is the medium spiny neuron. Together with the neostriatum (caudate nucleus and putamen), the nucleus accumbens forms the striatum.


otolaryngologic surgical result of headache: improved


LTAS_STAAM Lipoteichoic acid synthase (sprot)

A protein that is a translation product of the ltaS gene in Staphylococcus aureus subsp. aureus Mu50.


influenza

An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system.


B cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A lymphocyte of B lineage that is capable of B cell mediated immunity.


Dimethyltryptamine

A tryptamine derivative having two N-methyl substituents on the side-chain.


bone marrow

The soft tissue that fills the cavities of bones.


diphtheria, tetanus toxoids and acellular pertussis vaccine


Peripheral Nerve Injuries

Sensory or motor loss of peripheral nerve function due to a traumatic event. (ACC)


Increased Sympathetic Activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


sympathetic ganglion

A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.


fifth lumbar dorsal root ganglion

The group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the fifth lumbar vertebra.


apolipoprotein A-I-binding protein

A protein that is a translation product of the human NAXE gene or a 1:1 ortholog thereof.


Microglia

A type of glial cell that mediates immune responses by clearing cellular debris and dead neurons from nervous tissue through phagocytosis.


TIRAP-dependent toll-like receptor 4 signaling pathway

The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


Myeloid Progenitor Cells

A hematopoietic stem cell found in the bone marrow that is committed to form erythrocytes, megakaryocytes, and all leukocytes except lymphocytes.


spinal cord injury

Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).


microglial cell activation involved in immune response

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


Pioglitazone

A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.


Azithromycin

A macrolide antibiotic useful for the treatment of bacterial infections.


diabetes mellitus

A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.


Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor 1+2 Ab.IgG


cenpe.S

A centromere-associated protein E that is encoded in the genome of frog.


mitogen-activated protein kinase

A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY.


Chronic painful neuropathy due to diabetes mellitus


transient receptor potential cation channel TRPA1

A transient receptor potential cation channel TRPA that is a translation product of the human TRPA1 gene or a 1:1 ortholog thereof.


adenylate cyclase type 1

A protein that is a translation product of the human ADCY1 gene or a 1:1 ortholog thereof.


Rap guanine nucleotide exchange factor 3

A protein that is a translation product of the human RAPGEF3 gene or a 1:1 ortholog thereof.


Vascular Endothelial Growth Factor Receptor-2


neurogenic locus notch homolog protein 1

A NOTCH protein that is a translation product of the human NOTCH1 gene or a 1:1 ortholog thereof.


angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.


atherosclerosis

Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.


acute lung injury

A condition of lung damage that is characterized by bilateral pulmonary infiltrates (pulmonary edema) rich in neutrophils, and in the absence of clinical heart failure. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).


trigeminal ganglion

The cranial ganglion that is associated with and extends fibers into the trigeminal nerve.


afferent neuron

A neuron which conveys sensory information centrally from the periphery.


Endosomes

A membrane bound cytoplasmic compartment that drives molecular traffic between the plasma membrane and lysosome.


A substance-P receptor that is encoded in the genome of human.


plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.


Aprepitant

A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors.


spinal neuromere

A neuromere that is part of the presumptive spinal cord.


central amygdaloid nucleus

The output region of the amygdala responsible for controlling responses (Phelps & LeDoux, 2005, http://www.ncbi.nlm.nih.gov/pubmed/ 16242399).


GABAergic neuron

A neuron that uses GABA as a vesicular neurotransmitter


parafascicular nucleus

Part of the posterior (caudal) intralaminar group of thalamic nuclei, located medial to the centromedian nucleus and ventral to the dorsomedial nuclei, that is associated with the limbic and associative striatum.


pain disorder associated with psychological and physical factors


glial cell

A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.


sphingolipid

Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.


glutamate receptor 1

An ionotropic glutamate receptor protein that is a translation product of the human GRIA1 gene or a 1:1 ortholog thereof.


glutamate receptor 2

An ionotropic glutamate receptor protein that is a translation product of the human GRIA2 gene or a 1:1 ortholog thereof.


NRCAM

A neuronal cell adhesion molecule that is encoded in the genome of human.


probable G-protein coupled receptor 160

A rhodopsin-like G-protein coupled receptor that is a translation product of the human GPR160 gene or a 1:1 ortholog thereof.


A probable G-protein coupled receptor 160 that is encoded in the genome of mouse.


CARTPT

A cocaine- and amphetamine-regulated transcript protein that is encoded in the genome of human.


Corticosteroid derivatives, antimigraine drugs


Calcitonin-Gene Related Peptide Receptor


NAD-dependent protein deacetylase sirtuin-1

A protein that is a translation product of the human SIRT1 gene or a 1:1 ortholog thereof.


calcium/calmodulin-dependent protein kinase type II subunit alpha

A calcium/calmodulin-dependent protein kinase type II chain that is a translation product of the human CAMK2A gene or a 1:1 ortholog thereof.


Tenoxicam

A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine.  Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries.


A methyl-CpG-binding protein 2 that is encoded in the genome of human.


near-projecting glutamatergic cortical neuron

A glutamatergic neuron located in the cerebral cortex that projects axons locally rather than distantly.


Toll-like receptor 7

A Toll-like receptor that is a translation product of the human TLR7 gene or a 1:1 ortholog thereof.


transcription factor NF-kappa-B subunit

A protein that has a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region.


metabotropic glutamate receptor 2

A metabotropic glutamate receptor protein that is a translation product of the human GRM2 gene or a 1:1 ortholog thereof.


tibia

The major preaxial endochondral bone in the posterior zeugopod[Phenoscape].


germinal center

A collection of activated B cells at the center of a secondary follicle, formed after B cells become activated and migrate to the center.


T follicular helper cell

A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production.


IgM heavy chain protein

An immunoglobulin heavy chain protein in which the constant region is encoded by the IgM gene segment.


neuroma

A tumor that grows from a nerve or is composed of nerve cells and nerve fibers.


A cyclin-dependent kinase 5 that is encoded in the genome of fruit fly.


transient receptor potential channel protein

A voltage-gated ion channel protein that is a translation product of the human TRPC1, TRPM1, TRPV1, TRPA1, TRPP1 or TRPML1 gene, paralogs thereof, 1:1 orthologs thereof, a semi-ortholog thereof, or pro-orthologs thereof.


voltage-gated calcium channel protein

A voltage-gated ion channel protein that has voltage-gated calcium channel activity. A voltage-gated calcium channel enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


synaptophysin

A protein that is a translation product of the human SYP gene or a 1:1 ortholog thereof.


ocular anti-inflammatory ketorolac tromethamine


Fibrillary astrocyte

A neuroglial cell of ectodermic origin having long, thin, infrequently branched cytoplasmic processes containing numerous fibrillar structures. It is found mainly in the white matter of the brain.


immature microglial cell

An immature microglial cell with a ramified morphology.


CD14-positive, CD16-negative classical monocyte

A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive.


cyclic AMP-dependent transcription factor ATF-3 isoform 1

A cyclic AMP-dependent transcription factor ATF-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18847-1 or a 1:1 ortholog thereof.


tarsal region

Mesopodial segment of the pes, including the tarsal skeleton and associated tissues.


Synovial tissue of joint OR tendon sheath OR aponeurosis


legumain

A protein that is a translation product of the human LGMN gene or a 1:1 ortholog thereof.


oral cavity squamous cell carcinoma

A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status.


cAMP-dependent protein kinase type 1

A protein that is a translation product of the yeast TPK1 gene or a 1:1 ortholog thereof.


A C-C chemokine receptor type 2 that is encoded in the genome of human.


MHC-II-positive classical monocyte

Gr1-high monocyte that has a MHC-II receptor complex.


Neuroimmunomodulation

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


complex regional pain syndrome type 1

Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb.


complement C5

A protein that is a translation product of the human C5 gene or a 1:1 ortholog thereof.


G-protein coupled receptor

A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.


Rho

A rhodopsin that is encoded in the genome of mouse.


Mesenchymal Stem Cells

An undifferentiated stromal cell with the ability to develop into the cells that form distinct mesenchymal tissues; such as bone, muscle, connective tissue, blood vessels, and lymphatic tissue.


An interleukin-10 that is encoded in the genome of human.


negative regulation of opioid receptor signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway.


T cell

A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.


effector-mediated suppression of host innate immune response

A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


dihydropyrimidinase-related protein 2

A protein that is a translation product of the human DPYSL2 gene or a 1:1 ortholog thereof.


Numb-like protein

A protein that is a translation product of the human NUMBL gene or a 1:1 ortholog thereof.


sodium channel activity

Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.


Heat intolerance

The inability to maintain a comfortable body temperature in warm or hot weather.


Isoquercetin

A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells


Primidone

A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an  anticonvulsant for treatment of various types of seizures.


transient receptor potential cation channel TRPV4

A transient receptor potential cation channel TRPV that is a translation product of the human TRPV4 gene or a 1:1 ortholog thereof. The functional subunits are ion-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification.


transient receptor potential cation channel TRPM8

A transient receptor potential channel protein that is a translation product of the human TRPM8 gene or a 1:1 ortholog thereof. TRPM8 is a member of the subfamily M of the transient receptor potential cation channels (TRPs). In common with other TRPs, these proteins have amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity.TRPM8 forms a nonselective cation channel that is activated by cold and by menthol and other substances that produce the sensation of coolness. These channels exhibit voltage-dependance and regulation by phosphatidylinositol-4,5-bisphosphate (PIP2).


trigeminal nuclear complex

The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP].


Structure of spinal sensory afferent system


stimulatory killer cell immunoglobulin-like receptor signaling pathway

The series of molecular signals initiated by a ligand binding to a killer cell immunoglobulin-like receptor capable of cellular activation.


Lymphadenopathy

Enlargment (swelling) of a lymph node.


peripheral neuropathy

A disorder affecting the peripheral nervous system. It manifests with pain, tingling, numbness, and muscle weakness. It may be the result of physical injury, toxic substances, viral diseases, diabetes, renal failure, cancer, and drugs.


fibromyalgia

A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation.


parathyroid hormone

A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof.


Mesenchymal Stromal Cells

A heterogeneous, non-hematopoietic fibroblast-like cell with the potential for differentiating into connective tissue cells of multiple lineages.  It plays a significant role in tissue repair and regeneration, and interacts with immune cells to downregulate the immune response and enable immunosuppression via the induction of tolerance.


complex regional pain syndrome

Complex regional pain syndrome (CRPS) is a rare neurologic disease painful progressive condition that corresponds to a group of disorders characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.


immune system

Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies.


A nuclear factor erythroid 2-related factor 2 that is encoded in the genome of human.


lumbar dorsal root ganglion

The group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae.


Cancer-Associated Pain

Pain associated with cancer or its diagnosis or treatment.


A transient receptor potential cation channel TRPA1 that is encoded in the genome of human.


tissue-resident macrophage

A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.


colitis

Inflammation of the colon.


Neuroinflammation

Activation of the brain's innate immune system in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the brain.


A phospholipid-transporting ATPase ABCA1 that is encoded in the genome of human.


A protein that is a translation product of the human FTO gene or a 1:1 ortholog thereof.


Hemorrhage

The flow of blood from a ruptured blood vessel.


methyladenine

Any member of the class of 6-aminopurines that is adenine bearing a single methyl substituent.


YTH domain-containing family protein 2

A protein that is a translation product of the human YTHDF2 gene or a 1:1 ortholog thereof.


islet amyloid polypeptide

A protein that is a translation product of the human IAPP gene or a 1:1 ortholog thereof.


mitochondrial fission factor

A protein that is a translation product of the human MFF gene, a 1:1 ortholog thereof, or pro-orthologs thereof.


Mitochondria

Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Mitochondria contain distinctive ribosomes, transfer RNAs, amino acyl t-RNA synthetases, and elongation and termination factors. Mitochondria depend upon genes within the nucleus for many essential messenger RNAs. Mitochondria consist of two sets of membranes, a smooth continuous outer coat and an inner membrane arranged in tubules or more often in folds that form platelike double membranes (cristae). Mitochondria are the principal energy source of the cell and contains the cytochrome enzymes of terminal electron transport and the enzymes of the citric acid cycle, fatty acid oxidation, and oxidative phosphorylation. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP.


Adm

A pro-adrenomedullin that is encoded in the genome of mouse.


Ctrc

A chymotrypsin-C that is encoded in the genome of mouse.


inactive serine protease RAMP

A protein that is a translation product of the human PAMR1 gene or a 1:1 ortholog thereof.


sensory ganglion

The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells.


bone element

Skeletal element that is composed of bone tissue.


glutamate receptor ionotropic, NMDA 1

An ionotropic glutamate receptor protein that is a translation product of the human GRIN1 gene or a 1:1 ortholog thereof.


CTSS

A cathepsin S that is encoded in the genome of human.


Ctss

A cathepsin S that is encoded in the genome of mouse.


trigeminal sensory nucleus

The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. The nucleus is divided into three parts, from rostral to caudal (top to bottom in humans): * The mesencephalic nucleus * The chief sensory nucleus (or pontine nucleus or main sensory nucleus or primary nucleus) * The spinal trigeminal nucleus[WP].


interleukin-1 receptor-associated kinase 4 phosphorylated form (mouse)

An interleukin-1 receptor-associated kinase 4 phosphorylated form in mouse.


Rheumatoid factor & Cyclic citrullinated peptide


neurofibromin proteolytic cleavage product

A neurofibromin that has been processed by proteolytic cleavage.


AP-2 complex subunit alpha-2

A protein that is a translation product of the human AP2A2 gene or a 1:1 ortholog thereof.


Astrocytes

A heterogeneous group of specialized neuroglial cells with many diverse supporting roles in the structure, function, and homeostasis of the central nervous system.


substance-P receptor isoform 1

A substance-P receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25103-1 or a 1:1 ortholog thereof.


spike train

A series of sequential, propagated action potentials occurring in a single cell.


sumoylated protein

A protein that includes at least one sumoylated lysine.


tryptophan derivative

An amino acid derivative resulting from reaction of tryptophan  at the amino group or the carboxy group, or from the replacement of any hydrogen of tryptophan  by a heteroatom. The definition normally excludes peptides containing tryptophan residues.


positive regulation of secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.


A short transient receptor potential cation channel TRPC4 that is encoded in the genome of mouse.


EC 3.5.1.98 (histone deacetylase) inhibitor

An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).


microvillous olfactory receptor neuron

An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli.


neurotensin receptor type 2

A neurotensin receptor that is a translation product of the human NTSR2 gene or a 1:1 ortholog thereof. This receptor has a low affinity for neurotensin compared with neurotensin receptor 1 and neurotensin binding is selectively blocked by levocabastine.


A voltage-dependent calcium channel subunit alpha-2/delta-3 that is encoded in the genome of rat.


enterocyte of colon

A columnar cell of the colon that is part of the colonic epithelium.


HT29 Cells

An adenocarcinoma cell line established from a 44 year old Caucasian female patient with colon carcinoma.


Schwann Cells

A supporting cell of the peripheral nervous system that aids the growth, development, function, maintenance and repair of peripheral nerves. Myelinating Schwann cells form the myelin sheath around large diameter axons while non-myelinating Schwann cells bundle together portions of several unmyelinated smaller diameter axons and may also play a role in the formation and maintenance of synaptic connections in the neuromuscular junction.


reactive oxygen species

Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.


calcitonin gene-related peptide receptor signaling pathway

The series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers.


Mental and behavioral disorders due to use of opioids, dependence syndrome


CD8-Positive T-Lymphocytes

A subset of T-lymphocytes that express the CD8 surface glycoprotein and bind epitopes that are part of class I histocompatibility molecules. CD8-positive T-lymphocytes include cytotoxic T-lymphocytes and CD8+ suppressor T-lymphocytes.


A protein that is a translation product of the human IL13 gene or a 1:1 ortholog thereof. Interleukin-13 is a pleiotropic cytokine which may be important in the regulation of the inflammatory and immune responses. It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related.


T-cell immunoglobulin and mucin domain-containing protein 2

A protein that is a translation product of the mouse Timd2 gene or a 1:1 ortholog thereof.


OXT

An oxytocin-neurophysin 1 that is encoded in the genome of human.


congenital insensitivity to pain-hypohidrosis syndrome

A hereditary sensory neuropathy characterized by congenital insensitivity to pain and decreased sweating and tear production that has material basis in homozygous mutation in the PRDM12 gene on chromosome 9q34.


A peptidyl-prolyl cis-trans isomerase FKBP5 that is encoded in the genome of mouse.


nitrotyrosine

A tyrosine derivative that is tyrosine substituted by a nitro group at unspecified position. A "closed" class.


nuclear factor erythroid 2-related factor 2

A protein that is a translation product of the human NFE2L2 gene or a 1:1 ortholog thereof.


cerebellum

Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA].


CTRC

A chymotrypsin-C that is encoded in the genome of human.


Mas-related G-protein coupled receptor A1

A Mas-related G-protein coupled receptor A that is a translation product of the mouse Mrgpra1 gene or a 1:1 ortholog thereof. RF-amide-related peptides are reported to be the preferred ligands.


Anterior crossbite involving single tooth


A probable G-protein coupled receptor 85 that is encoded in the genome of human.


urinary bladder

Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP].


interstitial cystitis

A rare chronic debilitating urogenital disease characterized by urinary frequency, urgency, and pelvic pain.


overactive bladder

Symptom of overactive detrusor muscle of the urinary bladder that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. urinary incontinence may or may not be present.


head and neck carcinoma

A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.


autonomic nerve

The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa.


ARSB

An arylsulfatase B that is encoded in the genome of human.


undifferentiated carcinoma of oral cavity


A beta-2 adrenergic receptor that is encoded in the genome of human.


Tumor Pain

A painful sensation caused by the tumor growth.


Fus

An RNA-binding protein FUS that is encoded in the genome of mouse.


brain hypoxia - ischemia

A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ischemia) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain edema; coma; and other conditions.


cerebral palsy

A group of disorders affecting the development of movement and posture, often accompanied by disturbances of sensation, perception, cognition, and behavior. It results from damage to the fetal or infant brain.


14-3-3 protein gamma

A 14-3-3 protein that is a translation product of the human YWHAG gene or a 1:1 ortholog thereof.


kappa-type opioid receptor

An opioid receptor protein that is a translation product of the human OPRK1 gene or a 1:1 ortholog thereof. The preferred ligand is dynorphin.


cAMP-mediated signaling

Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.


nervous system

The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].


skeleton

Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.


Bone pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.


dorsal horn interneuron

A CNS interneuron located in the dorsal horn of the spinal cord.


partial chromosome Y deletion

Male sterility due to chromosome Y deletion is characterized by a severe deficiency of spermatogenesis. Chromosome Y deletions are a frequent genetic cause of male infertility.


A protein that is a translation product of the human DNM1 gene or a 1:1 ortholog thereof.


An AAK1 gene translation product (human), isoforms h1 and h2.


Nisch

A nischarin that is encoded in the genome of mouse.


C-C motif chemokine 2

An eotaxin-like cytokine that is a translation product of the human CCL2 gene or a 1:1 ortholog thereof.


Development of individualized plan of care


opiate dependence

Disorders related or resulting from abuse or mis-use of opioids.


Mitochondrial 1555 A to G mutation positive


medication assisted treatment for substance abuse


HIV infectious disease

An infection caused by the human immunodeficiency virus.


Cigarette

biolink:PhysicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:PhysicalEssenceOrOccurrent


metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.


hormone

Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.


thought processes executive functions cognitive flexibility


Medical care

biolink:Activity biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Medical problem:Finding:Point in time:^Patient:Nominal


Drug Abstinence

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


ALCOHOL AND/OR DRUG SERVICES; ACUTE DETOXIFICATION (HOSPITAL INPATIENT)


Patient discharged against medical advice:Find:Pt:^Patient:Ord:CMS Assessment


Office of Logistics and Acquisition Operations


Centers for Medicare and Medicaid Services


Patient Protection and Affordable Care Act


susceptibility to HIV infection

The type species of lentivirus and the etiologic agent of acquired immunodeficiency syndrome (AIDS). It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.


behavioral health integration care management


Uninsured

biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


asthma

A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.


chronic obstructive pulmonary disease

A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.


Emergency Responders

biolink:Cohort biolink:StudyPopulation biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


hepatitis C virus infection

A viral infection caused by the hepatitis C virus.


Methamphetamine

A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.


Health Information National Trends Survey


BEHAVIORAL HEALTH COUNSELING AND THERAPY, PER 15 MINUTES


major depressive disorder

An episode of depression lasting two or more weeks without an intervening episode of mania.


Depression, CTCAE

A disorder characterized by melancholic feelings of grief or unhappiness.


Mental and behavioral disorders due to use of tobacco, harmful use


psychoactive substance abuse with psychoactive substance-induced disorder


office-based treatment for opioid use disorder


scooter training per 15 minutes over curbs


health behavior intervention, individual, each additional 15 minutes


Behavioral health outreach service (planned approach to reach a targeted population)


PDYN

A proenkephalin-B that is encoded in the genome of human.


Subsequent Relapse

The reemergence of a disorder as diagnosed by clinical and/or laboratory evidence following two or more documented periods of remission.


Spiritual nurse care consultation each 15 minutes


Hospital inpatient or observation discharge day management; more than 30 minutes on the date of the encounter


primary motor cortex

The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html.


urine

Excretion that is the output of a kidney.


Olanzapine

A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.


A cytochrome P450 2D6 that is encoded in the genome of human.


A kappa-type opioid receptor that is encoded in the genome of mouse.


A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human.


Pomc

A pro-opiomelanocortin that is encoded in the genome of mouse.


A sodium-dependent serotonin transporter that is encoded in the genome of mouse.


Tremor

An unintentional, oscillating to-and-fro muscle movement about a joint axis.


Malaise

A feeling of general discomfort, weakness, or lack of health.


Hyperhidrosis

Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather.


Tobacco, Alcohol, Prescription medications, and other Substance use screen


Exacerbations of Chronic Pulmonary Disease Tool Patient-Reported Outcome Questionnaire


digital therapeutics for autism spectrum disorder


heart disorder

A disease involving the heart and/or pericardium.


Early chronotype

A tendency towards rising very early in the morning and going to bed early in the evening.


Infection

The invasion of an organism's body tissues by disease-causing agents and their multiplication, as well as the reaction by the host to these organisms and/or toxins that the organisms produce.


using intravenous drugs and sharing needles


Drug addiction therapy using buprenorphine


Technical Problem

biolink:Phenomenon biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Respiratory insufficiency

Impairment of gas exchange within the lungs secondary to a disease process, neoplasm, or trauma, possibly resulting in hypoxia, hypercarbia, or both, but not requiring intubation or mechanical ventilation. Patients are normally managed with pharmaceutical therapy, supplemental oxygen, or both.


Sedated

A state of a lowered level of consciousness.


Nausea

A sensation of unease in the stomach together with an urge to vomit.


Vomiting

Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.


hepatitis

An active inflammatory process affecting the liver for more than six months. Causes include viral infections, autoimmune disorders, drugs, and metabolic disorders.


coordination of care - facilitation and coordination of treatment


Sustained Virologic Response

A finding of aviremia at a predetermined time point after the end of planned or actual treatment.


bipolar disorder

A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.


Medical Dictionary for Regulatory Activities Terminology (MedDRA)


Therapeutic substance unit characteristic

biolink:ClinicalAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


Complex posttraumatic stress disorder

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Narcosynthesis for psychiatric diagnostic and therapeutic purposes (eg, sodium amobarbital (Amytal) interview)


Does drink

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


cocaine dependence

A psychologically and socially impaired state, with or without physiological changes, that develops as a result of using cocaine and which leads to compulsive behaviors to acquire the substance.


cocaine abuse

Disorders related or resulting from use of cocaine.


harmful; use, nonprescribed drugs, non-dependence producing


liver disorder

A disease involving the liver.


Waiver services; not otherwise specified (nos)


Clinical decision support mechanism medicalis, as defined by the medicare appropriate use criteria program


Personalized ALL-specific Multi-HLA-binding Peptide Vaccine


alkaloid

Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is  exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.


operant conditioning

Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.


release of sequestered calcium ion into cytosol by Golgi

The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol.


morphine receptor activity

Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein.


indole alkaloid

An alkaloid containing an indole skeleton.


Obstetrical treatment/services, prenatal or postpartum


blood plasma

The liquid component of blood, in which erythrocytes are suspended.


A mu-type opioid receptor that is encoded in the genome of mouse.


ventral tegmental area

Unpaired midbrain region situated in the ventromedial portion of the reticular formation. The VTA is medial to the substantia nigra and ventral to the red nucleus, and extends caudally from the posterior hypothalamus in the diencephalon. The VTA contains dopamine neurons that project to various limbic and cortical areas and is a critical component of the brain's reward circuitry.


Hypercapnia

Abnormally elevated blood carbon dioxide (CO2) level.


Sensorimotor Cortex

The region of the brain that consists of the precentral and postcentral gyri and is involved in somatosensory and motor functions.


collection of basal ganglia

Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum.


epoxy fatty acid

A heterocyclic fatty acid containing an epoxide ring as part of its structure.


urea herbicide

An herbicide which is primarily composed of urea (also known as carbamide).


mu-type opioid receptor isoform 2

A mu-type opioid receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42866-2 or a 1:1 ortholog thereof.


serotonergic agonist

An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.


Phenylpiperidine derivatives, opioid analgesics


orexin/hypocretin receptor type 1

An orexin receptor that is a translation product of the human HCRTR1 gene or a 1:1 ortholog thereof.


epoxy fatty acid anion

An epoxy monocarboxylic acid anion resulting from the deprotonation of the carboxy group of any epoxy fatty acid.


3-hydroxy carboxylic acid

Any hydroxy carboxylic acid which contains a hydroxy group located beta- to the carboxylic acid group.


Fetal Heart Rate Variability

Fluctuations in the baseline fetal heart rate, determined in a 10 minute window while excluding accelerations and decelerations. They are irregular in amplitude and frequency and are visually quantitated as the amplitude of the peak to trough in beats per minute. Sinusoidal patterns are also excluded.


Hyperattenuation

Describes areas on an x-ray or CT scan that show up as brighter than surrounding tissues.


proto-oncogene tyrosine-protein kinase Src

A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human SRC gene or a 1:1 ortholog thereof.


calcium/calmodulin-dependent protein kinase type II chain

A protein with a core domain architecture consisting of a Protein kinase domain (Pfam:PF00069) and a C-terminal Calcium/calmodulin dependent protein kinase II Association (Pfam:PF08332) domain.


A phosphoprotein associated with glycosphingolipid-enriched microdomains 1 that is encoded in the genome of human.


Body Weight

biolink:OrganismAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


Shakes

Unsteadiness or trembling movements of the whole body or a body part.


5-hydroxytryptamine receptor 2B

A 5-hydroxytryptamine receptor 2 that is a translation product of the human HTR2B gene or a 1:1 ortholog thereof.


nociceptin receptor

An opioid receptor protein that is a translation product of the human OPRL1 gene or a 1:1 ortholog thereof. The preferred ligand is nociceptin.


electromyography repetitive stimulation decrement


Impaired acid inhibition of gastrin release


Autologous Oxidized Ovarian Tumor Cell Lysate Vaccine


heart valve disorder

A disease involving the cardial valve.


Hapten

A substance that can act as an epitope for an antibody but that lacks immunogenicity unless coupled to a larger carrier molecule.


Bradycardia

A slower than normal heart rate (in adults, slower than 60 beats per minute).


sleep apnea syndrome

A disorder characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep.


hypocretin neuropeptide precursor

A protein that is a translation product of the human HCRT gene or a 1:1 ortholog thereof.


A regulator of G-protein signaling 4 that is encoded in the genome of human.


A regulator of G-protein signaling 9 that is encoded in the genome of mouse.


Microsomes, Liver

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Hepatocyte

A parenchymal liver cell.


A cytochrome P450 3A4 that is encoded in the genome of human.


A cytochrome P450 2D9 that is encoded in the genome of mouse.


D-glucose

A glucose with D-configuration.


Transcutaneous stimulation of cervical branch of vagus nerve

biolink:Procedure biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Emotional Distress

Disturbed mental state characterized by moodiness, irritability, agitation, anxiety, and/or depression resulting from physical or mental stress.


Patellar compression test response (observable entity)


leptin

A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof.


CRP

A C-reactive protein that is encoded in the genome of human.


Chronic Prostatitis with Chronic Pelvic Pain Syndrome


Pelvic pain

Pain perceived in the area of the pelvis, the lower part of the abdomen located between the hip bones.


hospitalization length of stay (___ days)


Visual pathway structure

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Visual Disturbance

An interference to normal eyesight.


Serotonin

A primary amino compound that is the 5-hydroxy derivative of tryptamine.


Resting State Functional Connectivity Magnetic Resonance Imaging


opioid use with residual and late-onset opioid-induced psychotic disorder


International Network of Food Data Systems


Bayley Scales of Infant Development score


Breech presentation

A position of the fetus at delivery in which the fetus enters the birth canal with the buttocks or feet first.


chronic kidney disease

Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.


end stage renal failure

Long-standing and persistent renal disease with glomerular filtration rate (GFR) less than 15 ml/min.


Opioid use, unspecified with unspecified opioid-induced disorder


endometriosis

The growth of functional endometrial tissue in anatomic sites outside the uterine body. It most often occurs in the pelvic organs.


Chronic pelvic pain without obvious pathology


biomarker

A substance used as an indicator  of a biological state.


opioid use with specified opioid-induced disorder


Other ophthalmological diagnostic agents in ATC


Assessment for residential mental healthcare services


ribonucleic acid

High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins.


Substance use disorder diagnostic schedule


Nicotinic receptor agonist (disposition)


Non-excepted service provided at an off-campus, outpatient, provider-based department of a hospital


hereditary gastrointestinal stromal tumor


Injection Site

The anatomic site at which a medication or a vaccine is injected.


HMGS

A protein that is a translation product of the HMGS gene in Arabidopsis thaliana.


RNAx assist with setting realistic individual goals


Acupuncture-like transcutaneous electrical nerve stimulation


Patient monitoring system module, data memory


A C-C chemokine receptor type 2 that is encoded in the genome of mouse.


A C-C chemokine receptor type 5 that is encoded in the genome of mouse.


voltage-dependent calcium channel subunit alpha-2/delta-1

A protein that is a translation product of the human CACNA2D1 gene or a 1:1 ortholog thereof.


voltage-dependent calcium channel beta subunit-associated regulatory protein

A protein that is a translation product of the human CBARP gene or a 1:1 ortholog thereof.


Facial Pain

Painful sensation in the face.


A C-C motif chemokine 3 that is encoded in the genome of human.


hyaline cartilage tissue

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.


map kinase p38

A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (environmental stress, pro-inflammatory cytokines and lipopolysaccharide) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY.


A BMP receptor-regulated smad protein that is a translation product of the human SMAD5 gene or a 1:1 ortholog thereof.


smad5 isoform 1 phosphorylated form

A smad5 isoform 1 that includes at least one phosphorylated residue.


A runt-related transcription factor 2 that is encoded in the genome of human.


bictegravir / emtricitabine / tenofovir alafenamide


Hormones and their metabolites and precursors T - Z


voltage-gated sodium channel protein

A voltage-gated ion channel protein that has voltage-gated sodium channel activity. A voltage-gated sodium channel enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


Voltage-Gated Sodium Channel Type 8 Subunit alpha


Hypoxia, CTCAE

A disorder characterized by a decrease in the level of oxygen in the body.


Organoids

A three dimensional mass comprised of a cultured cell or tissue sample that resembles an in vivo tissue or organ. Organoids are grown in vitro from a combination of cells or tissue fragments cultured in medium containing a variety of biochemical factors.


peripheral nervous system neuron

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A neuron that is part of a peripheral nervous system.


spinal cord dorsal column

The wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception.


graphene oxide

A single carbon layer of the graphite oxide structure.


BMP Receptor Signaling Pathway

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


neurotransmitter release

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


high voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.


Stem cells

An unspecialized cell that has the capacity for reproduction through cell division and can be induced to differentiate into a tissue or organ specific cell.


eukaryotic translation initiation factor 5A


A serine/threonine-protein kinase 25 that is encoded in the genome of human.


A cAMP-dependent protein kinase type I-alpha regulatory subunit that is encoded in the genome of rat.


cAMP-dependent protein kinase catalytic subunit

A protein that has a core domain composition consisting of a Protein kinase domain (Pfam:PF00069). Prototype members of this class are the catalytic subunit of PKA. Protein Kinase A (PKA) catalyzes the transfer of the terminal phosphate of ATP to Thr or Ser residues in a variety of protein substrates. The enzyme is composed of two subunit types: a catalytic subunit and a regulatory subunit. In the absence of cAMP, the two subunits are bound to each other and no catalysis can take place. In the presence of cAMP, the regulatory subunit binds cAMP, thus releasing the catalytic subunit.


health maintenance unlisted preventive medicine service


Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels


Hypertrophic interstitial neuropathy of trigeminal nerve


Abnormal fear-induced behavior

An abnormal fear-induced behavior includes observable actions. This behavior is characterized by abnormal responses to fear or abnormal fear levels. Examples of such behavior include avoiding fear-inducing situations.