serotonin uptake inhibitor

A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.


Serotonin

A primary amino compound that is the 5-hydroxy derivative of tryptamine.


A0A3B3DJS5_ORYME NudE neurodevelopment protein 1 (trembl)


Drug Exposure

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

Contact with drug.


Cardiac Index

The measure of an individual's cardiac output as divided by their body surface area (CI= CO/BSA). This calculation is a useful function to determine an individual's cardiac performance in relation to their body size, providing an overview of global cardiovascular function.


end stage renal failure

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

Long-standing and persistent renal disease with glomerular filtration rate (GFR) less than 15 ml/min.


chronic kidney disease

Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.


Stage 1 chronic kidney disease

A type of chronic kidney disease with normal or increased glomerular filtration rate (GFR at least 90 mL/min/1.73 m2).


endometriosis

The growth of functional endometrial tissue in anatomic sites outside the uterine body. It most often occurs in the pelvic organs.


Pelvic Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the pelvis.


uterine corpus leiomyoma

A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.


Hypertensive crisis

A severe, acute increase in blood pressure that may result in stroke or myocardial ischemia.


Sprinkle 24 HR topiramate 100 MG Extended Release Oral Capsule [Qudexy]


sexually transmitted disease

A Disease due to or propagated by sexual contact.


Injection Site

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The anatomic site at which a medication or a vaccine is injected.


Bloating

Distention of the abdomen associated with a feeling of fullness.


Elevated sweat chloride

An increased concentration of chloride in the sweat.


C5MKJ0_XENLA Calcium channel voltage-dependent T type Cav3.2, alpha 1h subunit (Fragment) (trembl)


A0A0J9X628_GEOCN Similar to Saccharomyces cerevisiae YOR299W BUD7 Member of the ChAPs family of proteins that forms the exomer complex to mediate export of specific cargo proteins from the Golgi to the plasma membrane (trembl)


A0A1C9ZQF2_CYNPY T-type calcium channel (Fragment) (trembl)


A0A0N9LV88_ORYSA Na+ and K+ transporter (trembl)


protein IL-40

A protein that is a translation product of the human C17orf99 gene or a 1:1 ortholog thereof.


A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group.


A0A5E4NC26_9HEMI SMAD/FHA domain,SMAD domain, Dwarfin-type,SMAD domain-like (trembl)


ribonuclease P protein subunit p38

A protein that is a translation product of the human RPP38 gene or a 1:1 ortholog thereof.


A runt-related transcription factor 2 that is encoded in the genome of human.


E9FVN7_DAPPU Putative Non voltage-gated ion channels inorganic ion transport and metabolism (trembl)


A sodium channel and clathrin linker 1 that is encoded in the genome of rat.


synaptic transmission, dopaminergic

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


Lidocaine

The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.


Peripheral Nerve Infection, CTCAE

A disorder characterized by an infectious process involving the peripheral nerves.


primary dorsal nerve cord

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A nerve cord in the dorsal mid-line that is the most prominent nerve cord.


graphene oxide

A single carbon layer of the graphite oxide structure.


bone morphogenetic protein

A TGF-beta-like cystine-knot cytokine that is related to the transforming growth factor-beta, anti-Muellerian hormone, and activin/inhibin protein families, which are all involved in the regulation of cell growth and differentiation. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release bioactive the C-terminal peptide. BMP is involved in body patterning and morphogenesis. BMP signals are transmitted through specific type 2 and type 1 receptors.


BMP signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


H6R1E8_NOCCG Putative voltage-gated potassium channels (trembl)


Neurotransmitter release cycle (Mus musculus)


A0A504XA82_FASGI High voltage activated calcium channel beta (trembl)


A0A1A8YVS7_9APIC Eukaryotic translation initiation factor 5A, putative (EIF5A) (trembl)


ryanodine receptor

A voltage-gated ion channel protein that is a translation product of the human RYR1, RYR2, or RYR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.


potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein

A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The N terminus has a conserved domain that is also present in other voltage-gated potassium and sodium channels. The carboxyl-terminal region contains the cyclic nucleotide-binding domain (CNBD). In addition, there is a structural element called the C-linker, the region connecting the CNBD to the S6 segment, which couples conformational changes in the ligand-binding domain to channel activation. Subunits combine to form the HCN channels. In common with CNG channels, HCN are cation channels that are modulated by cyclic nucleotide binding. Unlike CNG channels, HCN channels are voltage-gated, and are weakly selective for potassium. In contrast to most other voltage-gated channels, HCN channels open upon hyperpolarization and close at positive potential. HCN channels act as a pacemaker by regulating neuronal and cardiac firing rate, but also function as a regulator of membrane resting potential and resistance.


Q8CGS1_MOUSE Anti-deoxynivalenol scFv lambda light chain variable region (Fragment) (trembl)


A0A8S3SH31_MYTED Cephalotocin receptor 2,Vasopressin V1a receptor,Annetocin receptor,Cephalotocin receptor 1,Vasopressin V1b receptor,[Arg8]-vasotocin receptor,Isotocin receptor,Oxytocin receptor (trembl)


Intense psychological distress to cues

Intense or prolonged psychological distress occurs when individuals are exposed to internal or external cues that symbolize or resemble an aspect of the traumatic event or events.


obstructive sleep apnea syndrome

Cessation of air flow during sleep due to upper airway obstruction.


Rigidity

Continuous involuntary sustained muscle contraction. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from muscle spasticity.


Abnormality of the respiratory system

An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles.


Peak Oxygen Consumption

The highest rate of oxygen consumption a subject reaches during an aerobic capacity test.


Impaired ability to shift attention

A behavioral abnormality whereby a person is unable to move freely from one situation, activity or aspect of aa problem to another as circumstances demand. Key aspects of shifting include the ability to make transitions, problem solve flexibly, switch or alternate attention, and change focus from one mind-set or topic to another. Mild deficits in the ability to shift compromise the efficiency of problem solving, whereas more severe difficulties are reflected in perseverative behaviors. Sometimes this is described as being rigid or inflexible.


Adult onset

Onset of disease manifestations in adulthood, defined here as at the age of 16 years or later.


Flat Affect

The absence of emotional expressiveness.


A disorder characterized by a marked pattern of inattention and/or hyperactivity-impulsivity that is inconsistent with developmental level and clearly interferes with functioning in at least two settings (e.g. at home and at school). When present, the symptoms of hyperactivity are most often present before the age of 7 years. There are three recognized presentations or subtypes from most to least common: combined type, inattentive/distractible type, hyperactive/impulsive type.


12 HR clonidine hydrochloride 0.1 MG Extended Release Oral Tablet


Fair Skin

A human skin color characterized by low levels of eumelanin.


Mental and Behavioral Signs and Symptoms

Clinical evidence of disease resulting from mental and/or behavioral dysfunction.


autism spectrum disorder

A spectrum of developmental disorders that includes autism, and Asperger syndrome. Signs and symptoms include poor communication skills, defective social interactions, and repetitive behaviors.


non-steroidal anti-inflammatory drug

An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.


temporomandibular joint disorder

Any condition affecting the anatomic and functional characteristics of the temporomandibular joint.


Fractured bone of jaw

A partial or complete breakage of the bone of jaw.


nac

A GDP-fucose transporter 1 that is encoded in the genome of fruit fly.


sleep disorder

A change from the patient's baseline sleeping pattern, in the hours slept and/or an alteration/dysfunction in the stages of sleep.


Non restorative sleep

Perception of feeling unrefreshed after sleep.


diphenhydramine hydrochloride 25 MG Oral Capsule [Z-Sleep]


Chronic Disease

A disease condition that persists over a significant span of time.


dorsolateral prefrontal cortex

The dorsolateral prefrontal cortex (DL-PFC or DLPFC), according to a more restricted definition, is roughly equivalent to Brodmann areas 9 and 46.[1] According to a broader definition DL-PFC consists of the lateral portions of Brodmann areas 9 - 12, of areas 45, 46, and the superior part of area 47.[2] These regions mainly receive their blood supply from the middle cerebral artery. With respect to neurotransmitter systems, there is evidence that dopamine plays a particularly important role in DL-PFC.[2]DL-PFC is connected to the orbitofrontal cortex, and to a variety of brain areas, which include the thalamus, parts of the basal ganglia (the dorsal caudate nucleus), the hippocampus, and primary and secondary association areas of neocortex, including posterior temporal, parietal, and occipital areas.


Synaptic Vesicles

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Risky behavior

Engaging in dangerous, risky, and potentially self-damaging activities, without considering the consequences, is a sign of recklessness. It involves a disregard for one's limitations and a denial of personal danger.


Psychotic episodes

Periods of time during which an individual experiences significant disturbances in their thoughts, perceptions, emotions, and behavior, resulting in a loss of touch with reality. These episodes are hallmark features of psychotic disorders such as schizophrenia, schizoaffective disorder, and certain forms of bipolar disorder.


insomnia

A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep.


rhythmic behavior

The specific behavior of an organism that recur with measured regularity.


Dopamine

Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.


gABAergic system

Any molecule, protein, cell, tissue or organ that is related to GABA.


I7GMK5_MACFA Macaca fascicularis brain cDNA clone: QflA-22685, similar to human neuronal PAS domain protein 2 (NPAS2), mRNA, RefSeq: NM_002518.2 (trembl)


Impaired glucose tolerance

An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral or intravenous administration of glucose.


Addictive stimulant use

Addiction to a stimulant drug is defined as a drug that typically increases alertness, attention, and energy while also elevating blood pressure, heart rate, and breathing.


Pregabalin

A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.


Spastic gait

Spasticity is manifested by increased stretch reflex which is intensified with movement velocity. This results in excessive and inappropriate muscle activation which can contribute to muscle hypertonia. Spastic gait is characterized by manifestations such as muscle hypertonia, stiff knee, and circumduction of the leg.


postgastrectomy syndrome

Sequelae of gastrectomy from the second week after operation on. Include recurrent or anastomotic ulcer, postprandial syndromes (dumping syndrome and late postprandial hypoglycemia), disordered bowel action, and nutritional deficiencies.


cingulate cortex

The cingulate cortex is a part of the brain situated in the medial aspect of the cortex. It is extended from the corpus callosum below to the cingulate sulcus above, at least anteriorly. [WP,unvetted].