MGI:2684161

The study found that the paraventricular nucleus of the thalamus (PVT) plays a key role in the acquisition and maintenance of opiate-associated memories through its projections to the central nucleus of the amygdala (CeA) and nucleus accumbens (NAc). The activity of the PVT→CeA pathway associates morphine reward with the environment. Transient inhibition of the PVT→NAc pathway during retrieval provides enduring protection against opiate-primed relapse. The study also found that activating the downstream NAc→lateral hypothalamus (LH) pathway can prevent relapse. These findings suggest that the PVT→NAc→LH pathway could be a potential target for treating opioid addiction.


MGI:2684161


MGI:2684161

orchestrates acquisition and maintenance of


NCBIGene:40981


HP:5200293

The paper discusses the bi-directional relationship between sleep/alertness disturbance and substance use disorders (SUD). It suggests that sleep/alertness disturbance impacts all phases of the addiction cycle, including initiation, maintenance, and relapse of SUD. The study reviews various substances and concludes that sleep/alertness disturbance is a crucial factor in understanding and treating SUD.


GO:0030431

The paper reviews the relationship between sleep deficiency and opioid use, suggesting a bidirectional association between sleep efficiency and opioid abstinence. The authors propose that normalizing sleep deficiency could potentially improve opioid abstinence and vice versa. They also discuss potential mechanisms that could link improvements in sleep to opioid abstinence. The paper suggests that sleep-restorative therapeutic approaches should be examined in clinical trials as a potential solution to the opioid epidemic.


GO:0045938


HP:0002360


HP:5200292


EFO:0010702

The study investigates the feasibility of using a wireless sleep electroencephalography (EEG) monitor to measure sleep outcomes and architecture in patients undergoing supervised opioid withdrawal. The results showed that the wireless EEG could detect changes in total, NREM, and REM sleep time, and was associated with increased withdrawal severity, lower sleep efficiency, less time in REM and non-REM stages 1 and 2, and more hydroxyzine treatment. The study suggests that a wireless EEG is a feasible and useful tool for monitoring sleep in persons experiencing acute opioid withdrawal.


HP:0011179


EFO:0010702


PUBCHEM.COMPOUND:3658


EFO:0010702

The paper discusses the role of sleep health in opioid use disorder (OUD). It highlights that sleep disturbances are common in individuals with OUD, particularly during opioid withdrawal and maintenance therapies. These disturbances, which include reduced total sleep time, disrupted sleep continuity, and poor sleep quality, are often associated with negative OUD treatment outcomes. The paper also notes that sleep disturbances are bidirectionally linked with factors such as chronic stress, stress reactivity, low positive affect, high negative affect, chronic pain, and drug craving. Despite the potential benefits, there are few studies aimed at improving sleep health in OUD patients. The paper suggests that therapeutic interventions targeting sleep could be a promising avenue to improve OUD treatment.


EFO:0009937


EFO:0010702

The study conducted RNA sequencing on the dorsolateral prefrontal cortex and nucleus accumbens of postmortem brains from subjects with Opioid Use Disorder (OUD) and unaffected comparison subjects. The results revealed significant overlap in transcripts between the two brain regions in OUD, related to synaptic remodeling and neuroinflammation. The identified transcripts were enriched for factors controlling proinflammatory cytokine, chondroitin sulfate, and extracellular matrix signaling. Microglia were implicated as potential drivers for opioid-induced neuroplasticity. Genetic liabilities for risky behavior, attention-deficit/hyperactivity disorder, and depression were suggested in subjects with OUD.


EFO:0010702

The study investigates the correlation of drug-related dreams with opioid use disorder (OUD). The research found that individuals who recalled a drug-related dream in the past week were more likely to report recent sleep disturbances, including poor sleep quality, increased insomnia symptoms, and a higher risk for sleep apnea. Post-dream craving and distress were associated with greater insomnia symptoms, poor sleep hygiene behaviors, and increased anxiety symptoms. Those who had ever experienced a drug-related dream were more likely to report a history of severe withdrawal, overdose, and intravenous opioid use. The study suggests that interventions treating co-occurring OUD, pain, sleep symptoms, and affective symptoms may improve overall well-being in this population.


EFO:0010702

The study found that individuals with opioid use disorder (OUD) reported worsening sleep quality over their lifespan. Persistent sleep disturbances were associated with female sex, a greater number of treatment episodes, and positive screens for chronic pain and insomnia. The study suggests that OUD treatment providers should routinely screen for co-occurring sleep disturbance and chronic pain.


GO:0030237


EFO:0004609


HP:0012532


MONDO:0013600


EFO:0010702

The study found that people with opioid use disorder (OUD) have altered molecular rhythms in the dorsolateral prefrontal cortex (DLPFC) and nucleus accumbens (NAc), two key brain areas involved in OUD. In the DLPFC, fewer rhythmic transcripts were identified in subjects with OUD compared to unaffected subjects. In contrast, the NAc had nearly double the number of rhythmic transcripts in subjects with OUD. These rhythmic transcripts were associated with opioid, dopamine, and GABAergic neurotransmission. The study also found that these rhythmic transcripts were enriched for genomic loci associated with sleep-related traits, including sleep duration and insomnia.


GO:0007622


CHEBI:35482

The paper discusses the relationship between opioid use disorder (OUD) and sleep deficiency, a condition that affects 75% of patients with OUD. The study highlights the bidirectional mechanisms between OUD and sleep deficiency and the potential to target sleep deficiency with therapeutic interventions to promote long-term, healthy recovery among patients in OUD treatment. The effects of opioids on sleep quality, sleep architecture, sleep-disordered breathing, sleep apnea endotypes, ventilatory control, and implications for therapy and clinical practice are also discussed.


CHEBI:35482


EFO:0010702

The paper discusses the relationship between opioid use disorder (OUD) and sleep deficiency. OUD is a chronic brain disease that affects cognitive function, mood, pain perception, and autonomic activity. Sleep deficiency, which can be caused by various factors such as sleep disorders, circadian disruption, and poor sleep quality, is found in over 75% of OUD patients. The paper suggests that there are bidirectional mechanisms between OUD and sleep deficiency and identifies potential therapeutic targets.


MONDO:0003406


HP:0033485


EFO:0005272


MONDO:0005015

Painful diabetic neuropathy (PDN) is a common complication of chronic diabetes that can lead to significant disability and healthcare costs. Early symptom identification and aggressive glycemic control are crucial in controlling the development of neuropathic complications. However, adequate pain relief remains a challenge. Pharmacotherapy with anticonvulsants (pregabalin, gabapentin) and antidepressants (duloxetine) are common first-line agents. The use of oral opioids is discouraged due to associated morbidity, mortality, and potential for opioid-induced hyperalgesia. Neuromodulation treatment modalities including intrathecal drug delivery, spinal cord stimulation, and dorsal root ganglion stimulation are emerging as potential treatments. Holistic alternative therapies such as yoga and acupuncture may also be beneficial.


PUBCHEM.COMPOUND:5486971


PUBCHEM.COMPOUND:3446


PUBCHEM.COMPOUND:60835


CHEBI:49325


MESH:D054351

The study investigates the use of epidural electrical stimulation of the conus medullaris in a patient with complete L1 paraplegia and neuropathic genital pain due to a traumatic conus injury. The patient underwent spinal cord stimulator (SCS) implantation and an intensive outpatient physical therapy regimen. After 18 months, the patient showed advancement in motor zones of partial preservation (ZPPs) and qualitative increases in lower extremity resting state EMG amplitudes. However, there was no consistent evidence of voluntary EMG or rhythmic locomotive leg movements. The patient's quality of life improved significantly, suggesting potential for neuroplasticity in this patient population.


HP:0100561


MESH:D054351

Motor zones of partial preservation (ZPPs)


MESH:D054351

Lower extremity resting state EMG amplitudes


MESH:D054351


MONDO:0011382

The study investigates the impact of Sickle cell disease (SCD) on gait in humanized transgenic BERK sickle mice. The researchers found that Purkinje cells, which are associated with movement and neural function, undergo increased apoptosis in sickle mice, potentially leading to compensatory gait changes. Using an automated gait measurement system, MouseWalker, they found that sickle mice showed alterations in stance instability and dynamic gait parameters. These alterations may be due to motor dysfunction from damaged Purkinje cells or from fear and/or anticipation of movement-evoked pain. The study also found correlations between certain gait parameters and both mechanical and deep tissue hyperalgesia.


HP:0007001


HP:0002064


HP:0100561

The study investigates the management of generator site pain, also known as "pocket pain", in patients undergoing spinal cord stimulation (SCS). The research involved a review of all SCS permanent implants and implantable pulse generator (IPG) placements over a period of 9 years. Out of 785 cases, 43 patients were identified with pocket pain. The study found that females were overrepresented in the pocket pain cohort. The diagnoses included failed back surgery syndrome, complex regional pain syndrome, and chronic neuropathic pain. None of the patients improved with conservative therapy, and all either underwent revision or explant. The study also found that significantly more pocket pain patients had workers' compensation insurance. The study concluded that pocket pain was inadequately managed with conservative treatments and that being female and having SCS filed under workers' compensation increased the risk of pocket pain.


MONDO:0004566


MONDO:0019369


MONDO:0024317


MONDO:0011382

The paper discusses the pain associated with sickle cell disease (SCD), which can be both acute and chronic. Acute pain is caused by vaso-occlusive crises (VOC), while the cause of chronic pain is still unknown. Opioids are the primary treatment for pain, but concerns over their long-term use and the opioid epidemic have led to a need for non-opioid therapies. The FDA has approved three drugs for the treatment of SCD, specifically to reduce VOC and impact the pathobiology of SCD.


MONDO:0011382


UniProtKB:Q9PUA9

The paper discusses the link between chronic low back pain (CLBP) and depression, and proposes a novel approach to treat CLBP using deep brain stimulation (DBS) of the subgenual cingulate cortex (SCC). The SCC is structurally connected to brain regions that mediate emotional processes and are implicated in both CLBP and depression, including the anterior cingulate cortex, medial prefrontal cortex, nucleus accumbens, and amygdala. The authors suggest that CLBP and depression share a common underlying brain network interconnected by the SCC.


UBERON:0003027


HP:0011425

The paper discusses the use of neuromodulation as a treatment for chronic neuropathic pain. Neuromodulation, a drug-free and non-addictive method, involves transmitting controlled physical energy to specific neural targets in the central nervous system. The paper also discusses both invasive and non-invasive neuromodulation methods for pain management, with a particular focus on an emerging technology, transcranial focused ultrasound (tFUS). The safety and future prospects of transcranial ultrasound neuromodulation for pain management are also discussed.


HP:0011425


HP:0100561

The study presents an automated data visualization tool that generates patient-specific activity maps using intraoperatively collected signals. The tool is based on JavaScript/Python and provides a fast and robust visualization of electromyography (EMG) activity. The tool was tested using a High-resolution (HR)-SCS lead with 8 columns of electrodes spanning the dorsal columns. The tool provides a rapid and robust analysis of stimulation effects on various muscle groups and allows for direct comparison across subjects and/or stimulation settings.


NCIT:C34735

Intraoperative neurophysiological monitoring (IONM)


MGI:5517546


NCBITaxon:2724843


HP:0003457


UniProtKB:Q9PUA9

The paper discusses the use of deep brain stimulation (DBS) as a potential treatment for various neuropsychiatric disorders. The authors suggest that closed-loop DBS strategies, which use sensed neural signals to control stimulation, could overcome many of the limitations of open-loop stimulation. They provide a practical guide for implementing a closed-loop DBS system, using examples from patients with chronic pain. The guide includes details on how to adjust key parameters to manage feature selection, state thresholding, and stimulation artifacts.


UniProtKB:Q9PUA9


HP:0100561

High-resolution spinal cord stimulation (HR-SCS)

The study investigates the use of high-resolution spinal cord stimulation (HR-SCS) in patients with chronic pain. The HR-SCS paddle was found to stimulate medial-dorsal columns and extend stimulation coverage to laterally positioned spinal targets. The study found that the lateral contacts of the HR-SCS triggered stronger responses in medial gastrocnemius, adductor magnus, and tibialis anterior, while the medial contacts triggered stronger responses in gluteus maximus and adductor hallucis. The study suggests that HR-SCS may improve targeting of focal pain in the lower extremities.


HP:0100561


HP:0011425

The paper does not provide an abstract, but from the title, it can be inferred that the study involves the use of transcranial ultrasound neuromodulation to induce changes in neuronal correlation in the rat somatosensory cortex.