glutathione transferase activity

Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.


TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 3


TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 1


TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8


TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 2


GROWTH HORMONE-RELEASING HORMONE RECEPTOR


VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2


CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2


CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR


VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1


PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR


CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1


PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE TYPE I RECEPTOR


Cortocotropin releasing factor receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


peroxisomal matrix

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.


THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26


NUCLEAR PORE COMPLEX INTERACTING PROTEIN


NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER A1-RELATED


NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER B15-RELATED


NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER B11-RELATED


RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN


RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 2


RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1


MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10


HIPPOCAMPUS ABUNDANT TRANSCRIPT-LIKE PROTEIN 1


MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 9


HIPPOCAMPUS ABUNDANT TRANSCRIPT 1 PROTEIN


bile acid and bile salt transport

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1


NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED


NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6


SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 2


SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 1


E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED


GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN


ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA2


ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1


ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3


LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN


cell adhesion mediated by integrin

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.


POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 2


POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4


POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 3


POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1


OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4


GALACTOSIDE-BINDING SOLUBLE LECTIN 13-RELATED


carbohydrate binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.


negative regulation of extrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.


macrophage chemotaxis

The movement of a macrophage in response to an external stimulus.


regulation of extrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway.


negative regulation of endocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.


NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN


protein kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a protein kinase.


RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF


RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2


RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1


RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP3


actomyosin contractile ring assembly

The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.


mitotic cytokinetic process

Any cytokinetic process that is involved in mitotic cell cycle.


SIMILAR TO CHROMOSOME 1 OPEN READING FRAME 50


SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN  SCAMP


SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 1


SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 3


SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 2


SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 5


SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 4


mitotic DNA replication checkpoint signaling

A signal transduction process that contributes to a mitotic DNA replication checkpoint.


DNA replication checkpoint signaling

A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.


THADA/DEATH RECEPTOR INTERACTING PROTEIN


PROTEIN KINASE DOMAIN-CONTAINING PROTEIN


EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC


non-membrane spanning protein tyrosine kinase activity

Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.


CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN 1


FAST KINASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL


FAST KINASE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL


FAST KINASE DOMAIN-CONTAINING PROTEIN 2, MITOCHONDRIAL


FAST KINASE DOMAIN-CONTAINING PROTEIN 5, MITOCHONDRIAL


SERINE/THREONINE PROTEIN PHOSPHATASE 2A  PP2A  REGULATORY SUBUNIT B


SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM


SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM


SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM


SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM


SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM


28S RIBOSOMAL PROTEIN S18B, MITOCHONDRIAL


IQ CALMODULIN-BINDING MOTIF CONTAINING PROTEIN 1


IQ CALMODULIN-BINDING MOTIF-CONTAINING PROTEIN 1


site of DNA damage

A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.


site of double-strand break

A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.


replication fork

The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.


damaged DNA binding

Binding to damaged DNA.


establishment of planar polarity

Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.


stress fiber assembly

The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.


contractile actin filament bundle assembly

Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle.


GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 10-RELATED


GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 2


GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 7


39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL


organelle membrane contact site

A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.


elongator holoenzyme complex

A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA.


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 3


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 5


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 11


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 2


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 4


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 14


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 9


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 7


centriolar satellite

A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.


protein localization to cytoskeleton

A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.


ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 3


MYOCARDIN-RELATED TRANSCRIPTION FACTOR B


MYOCARDIN-RELATED TRANSCRIPTION FACTOR A


U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD


RNA-BINDING MOTIF PROTEIN, X-LINKED-LIKE-3


U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA


wide pore channel activity

Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.


MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29


THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN 3


PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED


RAS/RAP GTPASE-ACTIVATING PROTEIN SYNGAP


TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER


TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG


telomeric DNA binding

Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.


telomere maintenance via telomere lengthening

Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.


telomere maintenance via telomerase

The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.


ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR


EUKARYOTIC TRANSLATION INITIATION FACTOR 2C


chaperone-mediated protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.


LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1


endoplasmic reticulum unfolded protein response

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.


response to unfolded protein

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.


cellular response to unfolded protein

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.


regulation of mitotic spindle organization

Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.


INACTIVE CARBOXYPEPTIDASE-LIKE PROTEIN X2


metallocarboxypeptidase activity

Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR


regulation of protein modification by small protein conjugation or removal

Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal.


positive regulation of protein transport

Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


positive regulation of establishment of protein localization

Any process that activates or increases the frequency, rate or extent of establishment of protein localization.


PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED


PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46


PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 42


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 43


ADAM  A DISINTEGRIN AND METALLOPROTEASE DOMAIN


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 20


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 29


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 23


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 18


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 8


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 32


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 30


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 19


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 11


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 7


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 28


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 15


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 12


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 2


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 21


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33


DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 22


membrane protein proteolysis

The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.


membrane protein ectodomain proteolysis

The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN


RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING


heterochromatin

A compact and highly condensed form of chromatin that is refractory to transcription.


MAP KINASE KINASE KINASE SSK2-RELATED-RELATED


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14


I-kappaB kinase/NF-kappaB signaling

The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.


dynein complex binding

Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.


interstrand cross-link repair

Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.


mitotic intra-S DNA damage checkpoint signaling

A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.


reciprocal homologous recombination

A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules.


reciprocal meiotic recombination

The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.


homologous recombination

A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules.


SPECKLE TARGETED PIP5K1A-REGULATED POLY(A) POLYMERASE


VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN


VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN B/C


VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A


VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 33A


VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 45


VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 33B


exocytic process

The cellular processes that contribute to exocytosis.


late endosome to vacuole transport via multivesicular body sorting pathway

The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole.


late endosome to vacuole transport

The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.


multivesicular body sorting pathway

A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.


endosome transport via multivesicular body sorting pathway

The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.


28S RIBOSOMAL PROTEIN S12, MITOCHONDRIAL


BUTYROPHILIN SUBFAMILY 2 MEMBER A3-RELATED


V-SET DOMAIN-CONTAINING T-CELL ACTIVATION INHIBITOR 1


TRANSCRIPTIONAL ENHANCER FACTOR  TEF  RELATED


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 9


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 8A


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7C


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 43


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7A


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7B


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 22


OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1


OSTEOPETROSIS-ASSOCIATED TRANSMEMBRANE PROTEIN 1


10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL


NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2


NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3


NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1


ZINC FINGER AND SCAN DOMAIN CONTAINING 29


LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 3


LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 4


LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2


LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1


LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1


LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 2


LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 5


LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3


NKG2-C TYPE II INTEGRAL MEMBRANE PROTEIN


NKG2-F TYPE II INTEGRAL MEMBRANE PROTEIN


NKG2-A/NKG2-B TYPE II INTEGRAL MEMBRANE PROTEIN


regulation of natural killer cell mediated immunity

Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.


positive regulation of natural killer cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.


regulation of natural killer cell mediated cytotoxicity

Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.


DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 1


DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 2


V-TYPE PROTON ATPASE SUBUNIT B, BRAIN ISOFORM


V-TYPE PROTON ATPASE SUBUNIT B, KIDNEY ISOFORM


intracellular pH reduction

Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.


vacuolar acidification

Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.


MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN


CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 8


CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 7


CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3


CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2


CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 5


CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1


CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 4


CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 6


EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA


EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 3


EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1


translation initiation factor activity

Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.


CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65


UDP-N-ACETYLHEXOSAMINE PYROPHOSPHORYLASE-LIKE PROTEIN 1


NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1


MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE


STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE


INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA


INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON


INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA


ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1


ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 2


MONOFUNCTIONAL C1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL


BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE 2-RELATED


BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL


folic acid-containing compound metabolic process

The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.


CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA


CONSTITUTIVE COACTIVATOR OF PPAR-GAMMA-LIKE PROTEIN 1


CONSTITUTIVE COACTIVATOR OF PPAR-GAMMA-LIKE PROTEIN 2


REGULATOR OF G-PROTEIN SIGNALING 7-BINDING PROTEIN


REGULATOR OF G-PROTEIN SIGNALING 9-BINDING PROTEIN


response to light stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.


NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1


oxidoreductase activity, acting on metal ions

Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered.


negative regulation of blood pressure

Any process in which the force of blood traveling through the circulatory system is decreased.


JUNCTIONAL PROTEIN ASSOCIATED WITH CORONARY ARTERY DISEASE


HISTONE PARYLATION FACTOR 1-LIKE-RELATED


TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2


TORC2 signaling

A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.


12S RRNA N4-METHYLCYTIDINE (M4C) METHYLTRANSFERASE-RELATED


LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G5B


oligosaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.


CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS


CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 3


CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 1


CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21


neuron apoptotic process

Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.


neuron death

The process of cell death in a neuron.


negative regulation of B cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.


MYOD FAMILY INHIBITOR DOMAIN-CONTAINING PROTEIN


MYOD FAMILY INHIBITOR DOMAIN-CONTAINING PROTEIN 2


chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.


mitotic chromosome condensation

The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.


RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN


T CELL RECEPTOR GAMMA VARIABLE 3-RELATED


NON-FUNCTIONAL T CELL RECEPTOR GAMMA VARIABLE-RELATED


NON-FUNCTIONAL T CELL RECEPTOR GAMMA VARIABLE 10-RELATED


icosanoid biosynthetic process

The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids.


unsaturated fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.


prostaglandin biosynthetic process

The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.


BAG FAMILY MOLECULAR CHAPERONE REGULATOR 4


BAG FAMILY MOLECULAR CHAPERONE REGULATOR 3


BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1


BAG FAMILY MOLECULAR CHAPERONE REGULATOR 5


regulation of protein ubiquitination

Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.


negative regulation of protein ubiquitination

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.


U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM4


U4 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.


U5 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes.


pICln-Sm protein complex

A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.


U6 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.


P-body assembly

The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.


PRELI DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL


lipid transfer activity

Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids.


PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE


PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A


death receptor activity

Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death.


regulation of tissue remodeling

Any process that modulates the frequency, rate, or extent of tissue remodeling.


regulation of bone resorption

Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).


regulation of bone remodeling

Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.


EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1


EUKARYOTIC TRANSLATION INITIATION FACTOR 1


EUKARYOTIC TRANSLATION INITIATION FACTOR 1B


E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED


FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 2


FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 3B


FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 3A


E3 UBIQUITIN-PROTEIN LIGASE MID2-RELATED


FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 1


acrosome reaction

The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.


NUCLEAR RECEPTOR SUBFAMILY 6 GROUP A MEMBER 1


intracellular estrogen receptor signaling pathway

The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


intracellular steroid hormone receptor signaling pathway

The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor.


steroid hormone mediated signaling pathway

The series of molecular signals mediated by a steroid hormone binding to a receptor.


COMPLEMENT FACTOR H-RELATED PROTEIN 1-RELATED


COMPLEMENT FACTOR H-RELATED PROTEIN 3-RELATED


complement binding

Binding to a component or product of the complement cascade.


O-methyltransferase activity

Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.


ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE


SCF ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).


Cul4-RING E3 ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.


SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


ARGININE/SERINE RICH SPLICING FACTOR SF4/14


SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 1


SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 2


ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED


ZIPPER PUTATIVE TUMOR SUPPRESSOR 3-RELATED


ZIPPER PUTATIVE TUMOR SUPPRESSOR 1-RELATED


ZIPPER PUTATIVE TUMOR SUPPRESSOR 2-RELATED


B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR


T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN


E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED


mitochondrial respiratory chain complex I

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.


respiratory chain complex I

Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex.


mitochondrial electron transport, NADH to ubiquinone

The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.


HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN-RELATED


IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB


CLATHRIN HEAVY CHAIN LINKER DOMAIN-CONTAINING PROTEIN 1


positive regulation of protein polymerization

Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.


negative regulation of protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.


regulation of centrosome cycle

Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation.


regulation of centriole replication

Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole.


regulation of centrosome duplication

Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.


mRNA cleavage factor complex

Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules.


COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 8


COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 6


COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 1


COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 4


MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER


metaphase/anaphase transition of cell cycle

The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle.


metaphase/anaphase transition of mitotic cell cycle

The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA


FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 6-RELATED


FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 4


FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 7


FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 3


FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 5


COILED-COIL DOMAIN-CONTAINING PROTEIN 115


STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED


oxidoreductase activity, acting on a sulfur group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


nucleoside transmembrane transporter activity

Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other.


28S RIBOSOMAL PROTEIN S33, MITOCHONDRIAL


ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 2


ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 3


ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 1


TATA-BINDING PROTEIN-ASSOCIATED FACTOR 2N


RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED


INTERFERON-STIMULATED 20 KDA EXONUCLEASE-LIKE 2


INTERFERON-STIMULATED GENE 20 KDA PROTEIN


MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED


MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3 BETA 2-RELATED


GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1


GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 3


MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3C


MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3A


GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN


GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 2


MEGAKARYOCYTE AND PLATELET INHIBITORY RECEPTOR G6B


myeloid cell development

The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.


PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED


ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR


Beta3 adrenergic receptor signaling pathway


negative regulation of lyase activity

Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


negative regulation of cyclase activity

Any process that stops or reduces the activity of a cyclase.


negative regulation of adenylate cyclase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.


histone deacetylation

The modification of histones by removal of acetyl groups.


NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED


NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA, MUSCLE-SPECIFIC FORM


NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA-2


NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA-LIKE PROTEIN-RELATED


Fanconi anaemia nuclear complex

A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage.


MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4


MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3


MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7


MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1


MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2


MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9


MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6


MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5


CHORION-SPECIFIC TRANSCRIPTION FACTOR GCMA


CHORION-SPECIFIC TRANSCRIPTION FACTOR GCMB


DNA methylation

The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.


DNA alkylation

The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis.


COBW DOMAIN-CONTAINING PROTEIN 1-RELATED


GOLGI-ASSOCIATED OLFACTORY SIGNALING REGULATOR


ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5


ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 5-LIKE PROTEIN


MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED


MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 1


MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 2


LYSOSOMAL AMINO ACID TRANSPORTER 1 HOMOLOG


L-lysine transmembrane transporter activity

Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid.


KH DOMAIN CONTAINING RNA BINDING PROTEIN


INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 1


INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 3


INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 2


HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K


HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 2


HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 1


HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 4


HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 3


SPERMATID PERINUCLEAR RNA-BINDING PROTEIN


ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL


BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B


BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2A


TRANSCRIPTION INTERMEDIARY FACTOR 1-ALPHA


sphingolipid catabolic process

The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


ANDROGEN INDUCED INHIBITOR OF PROLIFERATION  AS3  / PDS5-RELATED


SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG B


SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG A


mitotic sister chromatid cohesion

The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.


sister chromatid cohesion

The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.


EXOCYST COMPLEX COMPONENT 3-LIKE PROTEIN


TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 2


EXOCYST COMPLEX COMPONENT 3-LIKE PROTEIN 4


OTU DEUBIQUITINASE WITH LINEAR LINKAGE-SPECIFICITY A-RELATED


TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED


TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13


FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 8


TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1-LIKE


TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1


TBP-class protein binding

Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).


JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN


JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 2C-RELATED


demethylase activity

Catalysis of the removal of a methyl group from a substrate.


histone demethylase activity

Catalysis of the removal of a methyl group from a histone.


TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 2


telomere localization

Any process in which a telomere is transported to, and/or maintained in, a specific location.


DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1


WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES  WIPI -RELATED


WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 1


WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 3


WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 4


WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 2


meiotic DNA double-strand break formation

The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.


U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10


De novo pyrimidine ribonucleotides biosythesis


RNA-BINDING PROTEIN WITH SERINE-RICH DOMAIN 1


SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNIZED BY T-CELLS 3


SHORT/BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL


VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL


E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED


CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157


neuromuscular junction

The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.


neuromuscular synaptic transmission

The process of synaptic transmission from a neuron to a muscle, across a synapse.


MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN


MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 6


MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 10


CELL FATE DETERMINING PROTEIN MAB21-RELATED


INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN-LIKE 2


INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN


INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN-LIKE 1


negative regulation of double-strand break repair via homologous recombination

Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination.


negative regulation of DNA repair

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.


regulation of double-strand break repair via homologous recombination

Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.


negative regulation of DNA recombination

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.


negative regulation of double-strand break repair

Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair.


regulation of DNA recombination

Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.


response to dsRNA

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus.


trans-Golgi network transport vesicle

A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.


calcium-ion regulated exocytosis

The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.


synaptic vesicle exocytosis

Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.


LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5


LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6


ENDOSOMAL/LYSOSOMAL POTASSIUM CHANNEL TMEM175


U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN


HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN C-LIKE 3-RELATED


HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS C1/C2


HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN C-LIKE 1-RELATED


AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT


5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-3


5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1


5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-2


PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN


MALE-SPECIFIC LETHAL-3 PROTEIN-LIKE 2-RELATED


ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN-RELATED


FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)


SPERMATOGENESIS-ASSOCIATED PROTEIN 2-LIKE PROTEIN


NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 2-RELATED


NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 1


NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 2


phosphatidylinositol 3-kinase signaling

A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.


28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL


KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 2


KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 1


CYCLIN-DEPENDENT KINASE INHIBITOR 1-RELATED


CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P


tRNA splicing, via endonucleolytic cleavage and ligation

Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.


SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN


WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1


CELL DIVISION CYCLE 20  CDC20   FIZZY -RELATED


CELL DIVISION CYCLE PROTEIN 20 HOMOLOG B


TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT


GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1


APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL


LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR  LZF1


CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG


respiratory chain complex IV assembly

The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms.


mitochondrial cytochrome c oxidase assembly

The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane.


protein folding chaperone complex

A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.


RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1


ATP-DEPENDENT RNA HELICASE DDX10-RELATED


ATP-DEPENDENT RNA HELICASE DDX27-RELATED


ATP-DEPENDENT RNA HELICASE DDX52-RELATED


ATP-DEPENDENT RNA HELICASE DDX31-RELATED


ATP-DEPENDENT RNA HELICASE DDX56-RELATED


ATP-DEPENDENT RNA HELICASE DDX49-RELATED


ATP-DEPENDENT RNA HELICASE DDX28-RELATED


ATP-DEPENDENT RNA HELICASE DDX47-RELATED


ATP-DEPENDENT RNA HELICASE DDX46-RELATED


cytoplasmic translation

The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.


cytoplasmic translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1  PGC-1 -RELATED


PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR-RELATED PROTEIN 1


PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-BETA


PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA


CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL


TRANSLOCON-ASSOCIATED PROTEIN  TRAP , GAMMA SUBUNIT


TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT GAMMA


26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6


RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2


PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC


NON-RECEPTOR TYROSINE-PROTEIN KINASE TNK1


B cell receptor signaling pathway

The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.


regulation of platelet activation

Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.


macrophage activation

A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


myeloid leukocyte activation

A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.


neutrophil activation

The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


bone remodeling

The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.


bone resorption

The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.


RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 1


RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 2


actin monomer binding

Binding to monomeric actin, also known as G-actin.


NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 8


PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7


COILED-COIL DOMAIN-CONTAINING PROTEIN 187


SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2


APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1


NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1


NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2


E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG


neuromuscular junction development

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.


SODIUM-INDEPENDENT SULFATE ANION TRANSPORTER


PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR-ASSOCIATED PROTEIN 1


EGF-CONTAINING FIBULIN-LIKE EXTRACELLULAR MATRIX PROTEIN 1


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A-RELATED


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4


peptidyl-prolyl cis-trans isomerase activity

Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).


NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT


UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5


ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3


UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7


UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1


UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7


UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6


post-translational protein modification

The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.


C-terminal protein amino acid modification

The alteration of the C-terminal amino acid residue in a protein.


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 7


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 6


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 13


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 11


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 2


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 9


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 4


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 5


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 10


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 8


PAIRED MESODERM HOMEOBOX PROTEIN 1-RELATED


NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1  NDUFV1


NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL


MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22


MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG


negative regulation of Notch signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.


CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL


CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL


DELETED IN AZOOSPERMIA PROTEIN 1-RELATED


TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 1


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED


protein kinase A binding

Binding to a protein kinase A.


protein kinase A regulatory subunit binding

Binding to one or both of the regulatory subunits of protein kinase A.


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14


TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 6


TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2


TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4


TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 5


POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN


TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1


TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 7


TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3


CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7


60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 HOMOLOG


protein kinase C binding

Binding to protein kinase C.


CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)


mRNA cis splicing, via spliceosome

The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.


ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 13


negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


negative regulation of proteasomal protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.


negative regulation of proteolysis involved in protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process.


SELENOCYSTEINE INSERTION SEQUENCE-BINDING PROTEIN 2


SELENOCYSTEINE INSERTION SEQUENCE-BINDING PROTEIN 2-LIKE


DNA replication origin binding

Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.


NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN


origin recognition complex

A multisubunit complex that is located at the replication origins of a chromosome.


nuclear origin of replication recognition complex

A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.


MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, LARGE SUBUNIT


MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN LARGE SUBUNIT


INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN


INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 6


INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 5


INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 4


INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2


INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3


INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1


SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54


SIGNAL RECOGNITION PARTICLE 54 KDA PROTEIN


NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L


kinetochore organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.


kinetochore assembly

The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.


AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 5A


AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4A


AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4B


AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 5B


PAXIP1-ASSOCIATED GLUTAMATE-RICH PROTEIN 1


nuclear estrogen receptor binding

Binding to a nuclear estrogen receptor.


EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER


SOLUTE CARRIER FAMILY 35 MEMBER G3-RELATED


SOLUTE CARRIER FAMILY 35 MEMBER G5-RELATED


CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1


WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 12


WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 10A


WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 13


WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 2


WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 3


WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 5


LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G5C


TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL


TRANSCRIPTION TERMINATION FACTOR 4, MITOCHONDRIAL


ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1


ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR


ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR 2


ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 2


RANBP2-LIKE AND GRIP DOMAIN-CONTAINING PROTEIN 1-RELATED


NLS-bearing protein import into nucleus

The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.


GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1


IMMEDIATE EARLY RESPONSE GENE 5-LIKE PROTEIN


COILED-COIL DOMAIN-CONTAINING PROTEIN 112


COILED-COIL DOMAIN-CONTAINING PROTEIN 148


KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 2


Adenine and hypoxanthine salvage pathway


adenosine deaminase activity

Catalysis of the reaction: adenosine + H2O = inosine + NH3.


glycosyl compound catabolic process

The chemical reactions and pathways resulting in the breakdown of glycosyl compound.


nucleoside catabolic process

The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


purine nucleobase metabolic process

The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.


purine nucleoside catabolic process

The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


nucleobase-containing small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.


PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL


CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 4


CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 3


CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 2


CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 1


microtubule plus-end binding

Binding to the plus end of a microtubule.


SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 2


positive regulation of DNA repair

Any process that activates or increases the frequency, rate or extent of DNA repair.


SHIFTLESS ANTIVIRAL INHIBITOR OF RIBOSOMAL FRAMESHIFTING PROTEIN


DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 3-RELATED


DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 3


CALCIUM-INDEPENDENT PHOSPHOLIPASE A2  IPLA2 -RELATED


PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 2


PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 5


PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 16


endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER X3


MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER X4


MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER E


MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER F


MAS-RELATED G-PROTEIN COUPLED RECEPTOR MRG-RELATED


MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER G


MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER X1


TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 13/17


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 13C


3-KETO-STEROID REDUCTASE/17-BETA-HYDROXYSTEROID DEHYDROGENASE 7


AP-type membrane coat adaptor complex

Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa).


CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED


POLY [ADP-RIBOSE] POLYMERASE TANKYRASE-1


POLY [ADP-RIBOSE] POLYMERASE TANKYRASE-2


regulation of telomere maintenance

Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.


CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL


RNA-BINDING MOTIF, SINGLE-STRANDED-INTERACTING PROTEIN 2


RNA-BINDING MOTIF, SINGLE-STRANDED-INTERACTING PROTEIN 1


RNA-BINDING MOTIF, SINGLE-STRANDED-INTERACTING PROTEIN 3


NEURONAL PAS DOMAIN-CONTAINING PROTEIN 1


ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1


NEURONAL PAS DOMAIN-CONTAINING PROTEIN 3


NEURONAL PAS DOMAIN-CONTAINING PROTEIN 4


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 1


RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2


SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG


PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3


CHARGED MULTIVESICULAR BODY PROTEIN 4B-LIKE PROTEIN CHMP4BP1-RELATED


ARMADILLO REPEAT PROTEIN DELETED IN VELO-CARDIO-FACIAL SYNDROME


intermediate filament bundle assembly

The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs.


dendritic spine morphogenesis

The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 1, MITOCHONDRIAL


[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL


INTEGRIN-LINKED KINASE-ASSOCIATED SERINE/THREONINE PHOSPHATASE 2C


PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1


TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1


COLLAGEN TRIPLE HELIX REPEAT-CONTAINING PROTEIN 1


SMALL NUCLEAR RIBONUCLEOPROTEIN F  SNRNP-F


U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6


SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT


SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL


TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED


TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1


SIMILAR TO HUMAN CHROMOSOME 6 OPEN READING FRAME 52


DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG


SPERM AXONEMAL MAINTENANCE PROTEIN CFAP97D1


protein-disulfide reductase activity

Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.


disulfide oxidoreductase activity

Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.


Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide.


peptide N-acetyltransferase activity

Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.


EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER


U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5


EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 12


RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3


RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 1


RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 2


RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2


RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1


Rac protein signal transduction

The series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.


isoprenoid catabolic process

The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


pigment biosynthetic process

The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin.


carotenoid biosynthetic process

The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail.


terpenoid biosynthetic process

The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.


MITOCHONDRIAL COILED-COIL DOMAIN PROTEIN 1


ATP-DEPENDENT RNA HELICASE DHX58-RELATED


ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I


INTERFERON-INDUCED HELICASE C DOMAIN-CONTAINING PROTEIN 1


cytosolic pattern recognition receptor signaling pathway

The series of molecular signals initiated by the binding of a ligand from another organism to a cytosolic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.


histone acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.


DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED


DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4


DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1


DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7


DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2


DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3


DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5


DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6


lymph vessel development

The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.


NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1


VIMENTIN-TYPE INTERMEDIATE FILAMENT-ASSOCIATED COILED-COIL PROTEIN


H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2


RIBOSOMAL L1 DOMAIN-CONTAINING PROTEIN 1


ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7


COILED-COIL DOMAIN-CONTAINING PROTEIN 183


DUAL SPECIFICITY TESTIS-SPECIFIC PROTEIN KINASE 1


DUAL SPECIFICITY TESTIS-SPECIFIC PROTEIN KINASE 2


positive regulation of actin filament bundle assembly

Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.


EXTRACELLULAR SERINE/THREONINE PROTEIN KINASE FAM20C


biomineral tissue development

Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.


DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7C


NADH DEHYDROGENASE  UBIQUINONE  IRON-SULFUR PROTEIN 3


NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL


PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE 2, CYTOPLASMIC


TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER


G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH 3


G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH 1


G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH 2


Alpha adrenergic receptor signaling pathway


vesicle fusion to plasma membrane

Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space.


CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 3-RELATED


IF ROD DOMAIN-CONTAINING PROTEIN-RELATED


DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9


DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10


DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12


transcription elongation by RNA polymerase II

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.


PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27


40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11


28S RIBOSOMAL PROTEIN S11, MITOCHONDRIAL


NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1


NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2


phagocytic vesicle

A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.


85/88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2


TESTIS-SPECIFIC PROTEIN 10-INTERACTING PROTEIN


SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2-RELATED


SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2


non-canonical Wnt signaling pathway

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 11


SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN


CITRATE SYNTHASE-LYSINE N-METHYLTRANSFERASE CSKMT, MITOCHONDRIAL


EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE


RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED


LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2


BRCA2-INTERACTING TRANSCRIPTIONAL REPRESSOR EMSY


CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4


CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3


CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3


SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 3


lysozyme activity

Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan.


SULFOTRANSFERASE FAMILY CYTOSOLIC 1B MEMBER 1


EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 13


VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 13


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11


RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1


RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE


RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12


Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade


TRANSLATION INITIATION FACTOR IF-2-RELATED


EUKARYOTIC TRANSLATION INITIATION FACTOR 5B


ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2  ASC-1 COMPLEX SUBUNIT P100


ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2


Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.


C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180


ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED


regulation of membrane permeability

Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane.


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27


2-OXOGLUTARATE DEHYDROGENASE E1 COMPONENT DHKTD1, MITOCHONDRIAL-RELATED


regulation of myeloid cell differentiation

Any process that modulates the frequency, rate or extent of myeloid cell differentiation.


positive regulation of myeloid cell differentiation

Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.


UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1


acetylcholine receptor regulator activity

Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.


OXIDATIVE STRESS-RESPONSE SERINE-RICH PROTEIN 1


OXIDATIVE STRESS-RESPONSIVE SERINE-RICH PROTEIN 1


TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6


TAF6-LIKE RNA POLYMERASE II P300/CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L


CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91


ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5


SCAN DOMAIN-CONTAINING PROTEIN SCAND2P-RELATED


ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3


GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN 4


GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN 5


syncytium formation by plasma membrane fusion

The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


syncytium formation

The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.


cell-cell fusion

A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.


NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 1-RELATED


NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 4-RELATED


NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 3


NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 7-RELATED


PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN


PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 1


PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 3


PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 2


CYTOSKELETON ASSOCIATED PROTEIN 2-RELATED


INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG


TRIMERIC INTRACELLULAR CATION CHANNEL TYPE A


TRIMERIC INTRACELLULAR CATION CHANNEL TYPE B


BROAD SUBSTRATE SPECIFICITY ATP-BINDING CASSETTE TRANSPORTER ABCG2


ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5


ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 8


ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 1


ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 4


ATP-binding cassette (ABC) transporter complex

A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.


sterol transfer activity

Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR


NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D


CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED


GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED


GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56


IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-6


IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-2


IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-1


IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-5


IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-4


IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-3


LLLL AND CFNLAS MOTIF-CONTAINING PROTEIN 1


EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G


WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER


GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1, MITOCHONDRIAL


GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 2, MITOCHONDRIAL


glycerol-3-phosphate metabolic process

The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol.


DNA-DIRECTED RNA POLYMERASE II SUBUNIT GRINL1A


COILED-COIL DOMAIN-CONTAINING PROTEIN 68


COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30


COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL


BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN


CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 6


MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2  NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN


MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2


DNA double-strand break processing

The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.


MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25


PROSTATE TUMOR-OVEREXPRESSED GENE 1 PROTEIN


STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE


CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS


PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED


PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN


DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 13


METHYLTRANSFERASE-LIKE PROTEIN 21E PSEUDOGENE-RELATED


HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG


PROTEIN N-LYSINE METHYLTRANSFERASE METTL21A


ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 11


ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3


ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 4-RELATED


ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1


ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2


SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER 1


SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER 2


RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2


FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 1


FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6


FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 5


FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 3


FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 2


FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 4


NUCLEAR UBIQUITOUS CASEIN AND CYCLIN-DEPENDENT KINASE SUBSTRATE 1


NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 16


ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3


ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1


DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2


DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11-A-RELATED


RNA polymerase II activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED


CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2


CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 46


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 10


TORC1 signaling

A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.


MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT  SPC22/23


UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1


SERINE/THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY ANKYRIN REPEAT SUBUNIT C


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 55


TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY A MEMBER 1


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 50


SERINE/THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY ANKYRIN REPEAT SUBUNIT B


SERINE/THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY ANKYRIN REPEAT SUBUNIT A


RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED


RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED


alpha-glucosidase activity

Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose.


CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE


CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA


CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED


CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 4


MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A


MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6


DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1


RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 4


RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1


RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 3


RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 5


RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 2


RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 6


regulation of NIK/NF-kappaB signaling

Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling.


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5


SERINE/ARGININE REPETITIVE MATRIX PROTEIN 5-RELATED


SERINE/ARGININE REPETITIVE MATRIX PROTEIN 5


26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED


26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5


PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 2


PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1


SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL


SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL


EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED


K63-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein.


AMILORIDE-SENSITIVE AMINE OXIDASE [COPPER-CONTAINING]


ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12


DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING


succinate transmembrane transporter activity

Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other.


WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1


DDB1- AND CUL4-ASSOCIATED FACTOR 8-LIKE PROTEIN 1


DDB1- AND CUL4-ASSOCIATED FACTOR 8-LIKE PROTEIN 2


CMT1A DUPLICATED REGION TRANSCRIPT 15 PROTEIN-LIKE PROTEIN


CMT1A DUPLICATED REGION TRANSCRIPT 15 PROTEIN


NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 37


BASIC SALIVARY PROLINE-RICH PROTEIN 1-RELATED


SALIVARY ACIDIC PROLINE-RICH PHOSPHOPROTEIN 1/2


TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5B-RELATED


COILED-COIL DOMAIN-CONTAINING PROTEIN 188


TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5A


SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2


TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5B


TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X


LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1


LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 2


NUCLEOSIDE DIPHOSPHATE KINASE, MITOCHONDRIAL


nucleoside diphosphate kinase activity

Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.


SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1-RELATED


TRANSCRIPTION FACTOR SMIF  DECAPPING ENZYME DCP1


RNA decapping

Cleavage of the 5'-cap of an RNA.


POST-GPI ATTACHMENT TO PROTEINS FACTOR 2


GPI anchor metabolic process

The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain.


GPI anchor biosynthetic process

The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.


MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1


RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED


39S RIBOSOMAL PROTEIN L47, MITOCHONDRIAL


E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED


NF-kappaB binding

Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.


UBIQUITIN LIGASE PROTEIN PHF9  FANCONI ANEMIA GROUP L PROTEIN


39S RIBOSOMAL PROTEIN L53, MITOCHONDRIAL


SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D


SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2


SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1


SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 3


TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 3


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3


DIACYLGLYCEROL O-ACYLTRANSFERASE 2-LIKE PROTEIN 6


EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 2-RELATED


EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 2B


EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 1


EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 2


NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3


CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA


PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED


SMALL INTEGRAL MEMBRANE PROTEIN 10-LIKE PROTEIN 2A-RELATED


FAMILY WITH SEQUENCE SIMILARITY 220 MEMBER A


SMALL INTEGRAL MEMBRANE PROTEIN 10-LIKE PROTEIN 1


TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER


TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG


protein N-linked glycosylation via asparagine

The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.


ENDOGENOUS RETROVIRUS GROUP S71 MEMBER 1 ENV POLYPROTEIN


ENDOGENOUS RETROVIRUS GROUP V MEMBER 1 ENV POLYPROTEIN-RELATED


ENDOGENOUS RETROVIRUS GROUP FC1 ENV POLYPROTEIN-RELATED


ENDOGENOUS RETROVIRAL ENVELOPE PROTEIN HEMO


ENDOGENOUS RETROVIRUS GROUP PABLB MEMBER 1 ENV POLYPROTEIN


ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 12-RELATED


ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 11


ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 8


G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2


ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 1


G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3


ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10


G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4


ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 15


G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1


ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 14


CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT DELTA-RELATED


CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT EPSILON


CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT DELTA


sperm principal piece

The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.


ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 5


ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 4


CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7


CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7


COILED-COIL DOMAIN-CONTAINING PROTEIN 58


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP11


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2


positive regulation of protein ubiquitination

Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.


UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1


GLUCOCORTICOID-INDUCED TRANSCRIPT 1 PROTEIN


ARSENICAL PUMP-DRIVING ATPASE  ARSENITE-TRANSLOCATING ATPASE


OOCYTE-SECRETED PROTEIN 1 HOMOLOG-RELATED


MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1


MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 BETA


meiotic sister chromatid cohesion

The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis.


GLUTATHIONE S-TRANSFERASE C-TERMINAL DOMAIN-CONTAINING PROTEIN


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED


sensory organ morphogenesis

Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


SERINE/THREONINE-PROTEIN KINASE MRCK GAMMA


SERINE/THREONINE-PROTEIN KINASE MRCK BETA


SERINE/THREONINE-PROTEIN KINASE MRCK ALPHA


BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1


CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 61


cellular response to abiotic stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.


cellular response to environmental stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus.


cellular response to light stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.


EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN


ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 1


DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE


ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 2