SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN 2


extrinsic component of cytoplasmic side of plasma membrane

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.


cytoplasmic side of plasma membrane

The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.


positive regulation of cation channel activity

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that activates or increases the frequency, rate or extent of cation channel activity.


skeletal muscle contraction

A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.


regulation of protein localization to membrane

Any process that modulates the frequency, rate or extent of protein localization to membrane.


positive regulation of ion transmembrane transporter activity

Any process that activates or increases the activity of an ion transporter.


positive regulation of transporter activity

Any process that activates or increases the activity of a transporter.


positive regulation of protein localization

Any process that activates or increases the frequency, rate or extent of a protein localization.


METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED


Methylmalonyl pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


BETA_GAMMA CRYSTALLIN DOMAIN-CONTAINING PROTEIN 1


BETA_GAMMA CRYSTALLIN DOMAIN-CONTAINING PROTEIN 2


visual perception

The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.


lens development in camera-type eye

The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.


immune response-regulating signaling pathway

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.


antigen receptor-mediated signaling pathway

The series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell.


immune response-regulating cell surface receptor signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.


immune response-activating cell surface receptor signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a cell, leading to the activation or perpetuation of an immune response.


immune response-activating signaling pathway

The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response.


T cell receptor signaling pathway

The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.


DIVALENT CATION TRANSPORTER  SOLUTE CARRIER FAMILY 41


C-C chemokine binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.


chemokine binding

Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


second-messenger-mediated signaling

Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell.


calcium-mediated signaling

Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.


leukocyte migration

The movement of a leukocyte within or between different tissues and organs of the body.


granulocyte migration

The movement of a granulocyte within or between different tissues and organs of the body.


neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


granulocyte chemotaxis

The movement of a granulocyte in response to an external stimulus.


myeloid leukocyte migration

The movement of a myeloid leukocyte within or between different tissues and organs of the body.


leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.


neutrophil migration

The movement of a neutrophil within or between different tissues and organs of the body.


MELANIN-CONCENTRATING HORMONE RECEPTOR 2


cytoskeletal motor activity

Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).


microtubule motor activity

A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.


plus-end-directed microtubule motor activity

A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis.


mitotic spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.


sister chromatid segregation

The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.


microtubule cytoskeleton organization involved in mitosis

Any microtubule cytoskeleton organization that is involved in mitosis.


spindle elongation

The cell cycle process in which the distance is lengthened between poles of the spindle.


mitotic spindle assembly

Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.


mitotic nuclear division

A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.


mitotic sister chromatid segregation

The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.


ATP-DEPENDENT RNA HELICASE DHX57-RELATED


ATP-DEPENDENT RNA HELICASE DHX40-RELATED


PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16


PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX32-RELATED


ATP-DEPENDENT RNA HELICASE DHX37-RELATED


PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16


ATP-DEPENDENT RNA HELICASE DHX35-RELATED


ATP-DEPENDENT RNA HELICASE DHX34-RELATED


ATP-dependent activity, acting on DNA

Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.


3'-5' DNA helicase activity

Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.


DNA helicase activity

Unwinding of a DNA helix, driven by ATP hydrolysis.


regulation of mRNA processing

Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.


protein-containing complex disassembly

The disaggregation of a protein-containing macromolecular complex into its constituent components.


positive regulation of transcription by RNA polymerase I

Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.


regulation of transcription by RNA polymerase I

Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I.


mitochondrial outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.


organelle outer membrane

The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope.


outer membrane

The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.


O-acyltransferase activity

Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.


RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF


tRNA binding

Binding to a transfer RNA.


ribonucleoprotein complex binding

Binding to a complex of RNA and protein.


ribosome binding

Binding to a ribosome.


NUCLEOPORIN P58/P45  NUCLEOPORIN-LIKE PROTEIN 1


nuclear pore

A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.


signal sequence binding

Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.


structural constituent of nuclear pore

The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.


transaminase activity

Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.


branched-chain amino acid metabolic process

The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.


branched-chain amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.


alpha-amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of an alpha-amino acid.


amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.


alpha-amino acid metabolic process

The chemical reactions and pathways involving an alpha-amino acid.


leucine biosynthetic process

The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.


skeletal muscle organ development

The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.


muscle organ development

The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.


skeletal muscle tissue development

The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.


thiosulfate sulfurtransferase activity

Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate.


sulfurtransferase activity

Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).


translation regulator activity

Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.


translation regulator activity, nucleic acid binding

Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.


translation elongation factor activity

Functions in chain elongation during polypeptide synthesis at the ribosome.


translation factor activity, RNA binding

Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.


OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6


OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 8


OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3


OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 10


OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 11


OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 7


OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 2


OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9


OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1


OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 5


steroid binding

Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.


sterol binding

Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.


cholesterol binding

Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


ZINC FINGER CCCH-TYPE ANTIVIRAL PROTEIN 1


DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 2


DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 4


fat cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.


synapse organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).


synapse assembly

The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).


heat shock protein binding

Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.


protein-folding chaperone binding

Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.


Hsp70 protein binding

Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.


'de novo' protein folding

The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure.


chaperone-mediated protein folding

The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.


chaperone cofactor-dependent protein refolding

The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.


ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6


ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 8


ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6


ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 4


ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 5


PURINE-RICH ELEMENT-BINDING PROTEIN GAMMA


TRANSCRIPTIONAL ACTIVATOR PROTEIN PUR-BETA


TRANSCRIPTIONAL ACTIVATOR PROTEIN PUR-ALPHA


EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 11


microtubule organizing center

An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.


centriole

A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.


centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.


Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction


tubulin binding

Binding to monomeric or multimeric forms of tubulin, including microtubules.


microtubule binding

Binding to a microtubule, a filament composed of tubulin monomers.


microtubule organizing center organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.


centriole assembly

A cellular process that results in the assembly of one or more centrioles.


centrosome cycle

The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.


centrosome duplication

The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.


nucleotide-excision repair

A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).


centriole replication

The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.


TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN


ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE


Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.


BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED


CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 23


CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 22


CLASS A BASIC HELIX-LOOP-HELIX PROTEIN 15


forebrain development

The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).


CYTOSOLIC 5'-NUCLEOTIDASE 1 FAMILY MEMBER


5'-nucleotidase activity

Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.


nucleotidase activity

Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.


nucleoside metabolic process

The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).


purine nucleoside metabolic process

The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


adenosine metabolic process

The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.


TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN


epithelial cell migration

The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.


substrate adhesion-dependent cell spreading

The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.


ameboidal-type cell migration

Cell migration that is accomplished by extension and retraction of a pseudopodium.


endothelial cell migration

The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.


tissue migration

The process in which the population of cells that make up a tissue undergo directed movement.


epithelium migration

The process in which the population of cells that make up an epithelium undergo directed movement.


IMMUNOGLOBULIN HEAVY VARIABLE 3-23-RELATED


IMMUNOGLOBULIN HEAVY VARIABLE 1-69-RELATED


IMMUNOGLOBULIN HEAVY VARIABLE 5-10-1-RELATED


IMMUNOGLOBULIN HEAVY VARIABLE 4-30-2-RELATED


IMMUNOGLOBULIN HEAVY VARIABLE 2-70-RELATED


IMMUNOGLOBULIN LAMBDA CONSTANT 1-RELATED


IMMUNOGLOBULIN HEAVY VARIABLE 3-21-RELATED


NON-FUNCTIONAL IMMUNOGLOBULIN HEAVY VARIABLE 8-51-1-RELATED


IMMUNOGLOBULIN HEAVY VARIABLE 3-53-RELATED


IMMUNOGLOBULIN HEAVY VARIABLE 3-43-RELATED


IMMUNOGLOBULIN LAMBDA-LIKE POLYPEPTIDE 1


IMMUNOGLOBULIN HEAVY VARIABLE 3-30-RELATED


IMMUNOGLOBULIN HEAVY VARIABLE 3_OR16-13 (NON-FUNCTIONAL)


NON-FUNCTIONAL IMMUNOGLOBULIN HEAVY VARIABLE 7-81-RELATED


NON-FUNCTIONAL IMMUNOGLOBULIN HEAVY VARIABLE 1-38-4-RELATED


immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.


B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.


SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52


VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG


vesicle tethering complex

Any protein complex that plays a role in vesicle tethering.


syntaxin binding

Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.


SNARE binding

Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.


vesicle-mediated transport to the plasma membrane

The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis.


post-Golgi vesicle-mediated transport

The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.


endocytic recycling

The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.


Golgi to vacuole transport

The directed movement of substances from the Golgi to the vacuole.


regulation of G1/S transition of mitotic cell cycle

Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.


negative regulation of G1/S transition of mitotic cell cycle

Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.


organelle disassembly

The disaggregation of an organelle into its constituent components.


regulation of cell cycle G1/S phase transition

Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 20A1-RELATED


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 18B


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 30A


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 7


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 26-RELATED


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 36A-RELATED


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 62


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 19-RELATED


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 30B


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 36C


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 18A


RBR FAMILY  RING FINGER AND IBR DOMAIN-CONTAINING


ANKYRIN REPEAT AND IBR DOMAIN-CONTAINING PROTEIN 1


ubiquitin-like protein conjugating enzyme binding

Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme.


positive regulation of proteasomal protein catabolic process

Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.


regulation of protein catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


regulation of proteolysis involved in protein catabolic process

Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process.


positive regulation of proteolysis

Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.


positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


regulation of ubiquitin-dependent protein catabolic process

Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


positive regulation of proteolysis involved in protein catabolic process

Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process.


positive regulation of ubiquitin-dependent protein catabolic process

Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


regulation of proteasomal protein catabolic process

Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.


positive regulation of protein catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


autophagy of mitochondrion

The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.


regulation of mitochondrion organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.


autophagy

The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.


process utilizing autophagic mechanism

A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway.


NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN  DOMAIN-CONTAINING


5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4


RNA CYTOSINE C(5)-METHYLTRANSFERASE NSUN2


STERILE20-LIKE KINASE, ISOFORM B-RELATED


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1


STE20_SPS1-RELATED PROLINE-ALANINE-RICH PROTEIN KINASE


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2


VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8E


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 58


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 2


VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8D


VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8A


PH DOMAIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN PHOSPHATASE 1


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 39


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40


P53-INDUCED DEATH DOMAIN-CONTAINING PROTEIN 1


PH DOMAIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN PHOSPHATASE 2


MALIGNANT FIBROUS HISTIOCYTOMA-AMPLIFIED SEQUENCE 1


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 30


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 69


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 59


VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8C


LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 2


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 63


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 18


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 28


VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8B


protein phosphatase binding

Binding to a protein phosphatase.


protein serine/threonine phosphatase activity

Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.


HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR


TRACE AMINE-ASSOCIATED RECEPTOR 3-RELATED


G protein-coupled amine receptor activity

Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR


GONADOTROPIN-RELEASING HORMONE II RECEPTOR-RELATED


PYROGLUTAMYLATED RF-AMIDE PEPTIDE RECEPTOR


Oxytocin receptor mediated signaling pathway


circadian rhythm

Any biological process in an organism that recurs with a regularity of approximately 24 hours.


rhythmic process

Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.


regulation of systemic arterial blood pressure

The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.


regulation of hormone secretion

Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.


organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.


carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.


monocarboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.


post-embryonic development

The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.


filopodium

Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.


ruffle

Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.


growth cone

The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.


site of polarized growth

Any part of a cell where non-isotropic growth takes place.


establishment or maintenance of cell polarity

Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.


actin filament bundle assembly

The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.


actin filament bundle organization

A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.


rRNA (guanine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine.


sarcoplasmic reticulum

A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.


growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.


positive chemotaxis

The directed movement of a motile cell or organism towards a higher concentration of a chemical.


positive regulation of canonical Wnt signaling pathway

Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


positive regulation of Wnt signaling pathway

Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.


regulation of canonical Wnt signaling pathway

Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


regulation of Wnt signaling pathway

Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.


positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.


regulation of cellular response to growth factor stimulus

Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.


positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.


regulation of chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.


REST COREPRESSOR  COREST  PROTEIN-RELATED


MITOTIC DEACETYLASE-ASSOCIATED SANT DOMAIN PROTEIN


histone deacetylase complex

A protein complex that possesses histone deacetylase activity.


transcription corepressor activity

A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.


SPERMATOGENESIS-ASSOCIATED PROTEIN 6 SPATA6


SPERMATOGENESIS ASSOCIATED 6-LIKE PROTEIN


TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN


TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 1


TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 2


TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 3


RNA GUANINE-7 METHYLTRANSFERASE-ACTIVATING SUBUNIT-LIKE (PSEUDOGENE)-RELATED


INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG


intraciliary transport particle B

The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa.


intraciliary transport particle

A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.


intraciliary transport

The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.


protein-containing complex localization

A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.


EWING'S TUMOR-ASSOCIATED ANTIGEN 1 ETAA1


mRNA export from nucleus

The directed movement of mRNA from the nucleus to the cytoplasm.


establishment of RNA localization

The directed movement of RNA to a specific location.


nucleic acid transport

The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


mRNA transport

The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


RNA localization

A process in which RNA is transported to, or maintained in, a specific location.


RNA transport

The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


RNA export from nucleus

The directed movement of RNA from the nucleus to the cytoplasm.


PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4


1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1


Metabotropic glutamate receptor group I pathway


phospholipase C activity

Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.


phosphatidylinositol-mediated signaling

The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.


release of sequestered calcium ion into cytosol

The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.


negative regulation of sequestering of calcium ion

Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49


rRNA transcription

The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.


nucleolar large rRNA transcription by RNA polymerase I

The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.


DNA-templated transcription elongation

The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.


ncRNA transcription

The transcription of non (protein) coding RNA from a DNA template.


C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1


C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 2


ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN


ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 2


ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1


phosphatidylinositol binding

Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.


phosphatidylinositol phosphate binding

Binding to phosphatidylinositol phosphate.


BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST


BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR SCLERAXIS


HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 2


HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 1


PANCREAS TRANSCRIPTION FACTOR 1 SUBUNIT ALPHA


CLASS A BASIC HELIX-LOOP-HELIX PROTEIN 9


COILED-COIL DOMAIN-CONTAINING PROTEIN 189


CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 119


CILIARY-ASSOCIATED CALCIUM-BINDING COILED-COIL PROTEIN 1


GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL


cytoplasmic stress granule

A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.


negative regulation of protein polymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.


negative regulation of protein depolymerization

Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization.


negative regulation of actin filament depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.


regulation of actin polymerization or depolymerization

Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.


regulation of protein-containing complex assembly

Any process that modulates the frequency, rate or extent of protein complex assembly.


negative regulation of protein-containing complex disassembly

Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.


barbed-end actin filament capping

The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.


regulation of protein polymerization

Any process that modulates the frequency, rate or extent of the process of creating protein polymers.


regulation of actin filament length

Any process that controls the length of actin filaments in a cell.


regulation of protein-containing complex disassembly

Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.


regulation of actin filament polymerization

Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.


negative regulation of supramolecular fiber organization

Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization.


regulation of protein depolymerization

Any process that modulates the frequency, rate or extent of protein depolymerization.


regulation of actin filament depolymerization

Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament.


negative regulation of actin filament polymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.


negative regulation of protein-containing complex assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.


negative regulation of cytoskeleton organization

Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.


GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN


transcription export complex 2

A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p.


GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-12


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-T2


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-10


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-5-RELATED


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-4


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-11


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-14-RELATED


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-7


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-3


GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT GAMMA-T1


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-8


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-2


5HT1 type receptor mediated signaling pathway


NEURON-SPECIFIC CALCIUM-BINDING PROTEIN HIPPOCALCIN


9+0 non-motile cilium

A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme).


non-motile cilium

A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.


photoreceptor outer segment

The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.


photoreceptor inner segment

The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.


potassium channel regulator activity

Binds to and modulates the activity of a potassium channel.


regulation of lyase activity

Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.


regulation of cyclase activity

Any process that modulates the frequency, rate or extent of cyclase activity.


positive regulation of cyclase activity

Any process that activates or increases the activity of a cyclase.


positive regulation of lyase activity

Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 6


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 39


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 37


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 20


POZ-, AT HOOK-, AND ZINC FINGER-CONTAINING PROTEIN 1


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 26


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 32


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 14


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 1


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 49


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 34


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 2


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 25


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 45


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 17


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 12


THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1


THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1


MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A39-RELATED


MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A40-RELATED


RNA cap binding

Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.


neuron projection guidance

The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.


positive regulation of cysteine-type endopeptidase activity

Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.


regulation of cysteine-type endopeptidase activity

Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity.


positive regulation of peptidase activity

Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.


zymogen activation

The proteolytic processing of an inactive enzyme to an active form.


positive regulation of endopeptidase activity

Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


axon guidance

The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.


modification of synaptic structure

Any process that modifies the structure/morphology of a synapse.


VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 1


VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 2


basement membrane

A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.


positive regulation of cell-substrate adhesion

Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


regulation of cell-substrate adhesion

Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


endoderm formation

The formation of the endoderm during gastrulation.


formation of primary germ layer

The formation of the ectoderm, mesoderm and endoderm during gastrulation.


endoderm development

The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.


gastrulation

A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.


TRANSCRIPTION ELONGATION FACTOR, MITOCHONDRIAL


mitochondrial transcription

The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.


NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN  DOMAIN-CONTAINING


phagophore assembly site

Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.


autophagosome

A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.


macroautophagy

The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.


peptidyl-serine phosphorylation

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.


lysosomal microautophagy

The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment.


response to starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.


peptidyl-serine modification

The modification of peptidyl-serine.


autophagosome assembly

The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.


piecemeal microautophagy of the nucleus

Degradation of a cell nucleus by lysosomal microautophagy.


nucleophagy

A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded.


regulation of axonogenesis

Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.


regulation of growth

Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.


axon extension

Long distance growth of a single axon process involved in cellular development.


regulation of cell growth

Any process that modulates the frequency, rate, extent or direction of cell growth.


SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2


sphingolipid metabolic process

The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


ceramide metabolic process

The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.


ceramide biosynthetic process

The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.


sphingolipid biosynthetic process

The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4C


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4B


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 3


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 53


glutamatergic synapse

A synapse that uses glutamate as a neurotransmitter.


cell-cell adhesion mediator activity

The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.


synaptic membrane adhesion

The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.


postsynapse organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.


regulation of synapse organization

Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).


positive regulation of synapse assembly

Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.


regulation of organelle assembly

Any process that modulates the frequency, rate or extent of organelle assembly.


positive regulation of cellular component biogenesis

Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.


regulation of postsynapse organization

Any process that modulates the physical form of a postsynapse.


regulation of synapse structure or activity

Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).


regulation of cell junction assembly

Any process that modulates the frequency, rate or extent of cell junction assembly.


positive regulation of Ras protein signal transduction

Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5B


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 22


ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 4


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 1


NEUROTROPHIN RECEPTOR-INTERACTING FACTOR HOMOLOG


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 21


ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 1


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 4


ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 3


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 31


ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 8


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 20


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 12


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 30


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 29


ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 2


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 32


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 16


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 9


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 23


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 26


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 41


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5C-RELATED


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 25


ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5A


spliceosomal tri-snRNP complex

A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP.


U4/U6 x U5 tri-snRNP complex

A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs.


THO complex

The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.


transcription export complex

The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.


AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B


AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 2


AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3


AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 1


Alzheimer disease-amyloid secretase pathway


amyloid-beta binding

Binding to an amyloid-beta peptide/protein.


BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 1


BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 3


regulation of cell shape

Any process that modulates the surface configuration of a cell.


odontogenesis of dentin-containing tooth

The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.


odontogenesis

The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.


amelogenesis

The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.


tissue remodeling

The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.


response to hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.


response to oxygen levels

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.


tetrapyrrole metabolic process

The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


pigment metabolic process

The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.


porphyrin-containing compound metabolic process

The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.


heme metabolic process

The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.


ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2


ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1


prenyltransferase activity

Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).


transferase activity, transferring alkyl or aryl (other than methyl) groups

Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).


isoprenoid metabolic process

The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


isoprenoid biosynthetic process

The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


ubiquinone biosynthetic process

The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.


ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL


TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A  MS4A -RELATED


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 3


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 10


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 13


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 18


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 6A


HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT BETA


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 7


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 14


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 12


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 15


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 4A


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 6E


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 5


MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 8


VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT


VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT


VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-8 SUBUNIT


VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT


VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-7 SUBUNIT


VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-3 SUBUNIT


VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-4 SUBUNIT


receptor internalization

A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.


regulation of postsynaptic membrane neurotransmitter receptor levels

Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.


establishment of protein localization to vacuole

The directed movement of a protein to a specific location in a vacuole.


protein localization to vacuole

A process in which a protein is transported to, or maintained at, a location in a vacuole.


regulation of synaptic transmission, glutamatergic

Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.


regulation of signaling receptor activity

Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.


protein localization to lysosome

A process in which a protein is transported to, or maintained in, a location within a lysosome.


ADENINE NUCLEOTIDE TRANSLOCASE LYSINE N-METHYLTRANSFERASE


ATP SYNTHASE SUBUNIT C LYSINE N-METHYLTRANSFERASE


N-methyltransferase activity

Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.


Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.


lysine N-methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue.


protein methyltransferase activity

Catalysis of the transfer of a methyl group (CH3-) to a protein.


COILED-COIL DOMAIN-CONTAINING PROTEIN 181


TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN


TRANSCRIPTION ELONGATION FACTOR A PROTEIN 1


TRANSCRIPTION ELONGATION FACTOR A N-TERMINAL AND CENTRAL DOMAIN-CONTAINING PROTEIN 2


TRANSCRIPTION ELONGATION FACTOR A N-TERMINAL AND CENTRAL DOMAIN-CONTAINING PROTEIN


TRANSCRIPTION ELONGATION FACTOR A PROTEIN 3


TRANSCRIPTION ELONGATION FACTOR A PROTEIN 2


39S RIBOSOMAL PROTEIN L51, MITOCHONDRIAL


structural constituent of ribosome

The action of a molecule that contributes to the structural integrity of the ribosome.


UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-2


UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-1


JANUS KINASE AND MICROTUBULE-INTERACTING PROTEIN 2


JANUS KINASE AND MICROTUBULE-INTERACTING PROTEIN 3


JANUS KINASE AND MICROTUBULE-INTERACTING PROTEIN 1


CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE


CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6


CCR4-NOT complex

The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8.


RNA destabilization

Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes.


mRNA destabilization

Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.


nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.


nuclear-transcribed mRNA poly(A) tail shortening

Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide.


dihydropyrimidinase activity

Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.


nucleobase metabolic process

The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.


pyrimidine nucleobase metabolic process

The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


pyrimidine nucleobase catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT


nuclear ubiquitin ligase complex

A ubiquitin ligase complex found in the nucleus.


PcG protein complex

A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.


PRC1 complex

A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.


CHROMOSOME ALIGNMENT-MAINTAINING PHOSPHOPROTEIN 1


EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED


EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6


TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 2


TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 6


TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 3


TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1


MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE


5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1


TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 4


5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2


establishment of cell polarity

The specification and formation of anisotropic intracellular organization or cell growth patterns.


negative regulation of intracellular signal transduction

Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.


negative regulation of TOR signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.


cellular response to starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.


cellular response to extracellular stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.


cellular response to nutrient levels

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.


cellular response to external stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.


SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 3C


LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 1


LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 3


LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 4


PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 29


LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 2


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 3B


INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT


TLR4 INTERACTOR WITH LEUCINE RICH REPEATS


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 24


LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 4


TRANSFORMING GROWTH FACTOR BETA ACTIVATOR LRRC32


LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 3


LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 1


LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1


LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 3


LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 2


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 17


lipopolysaccharide binding

Binding to a lipopolysaccharide.


regulation of cytokine production involved in immune response

Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.


pattern recognition receptor signaling pathway

The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.


toll-like receptor 4 signaling pathway

The series of molecular signals initiated by a ligand binding to toll-like receptor 4.


positive regulation of innate immune response

Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.


regulation of innate immune response

Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.


regulation of response to biotic stimulus

Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.


innate immune response-activating signaling pathway

The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an innate immune response.


activation of innate immune response

Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.


regulation of production of molecular mediator of immune response

Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.


positive regulation of defense response

Any process that activates or increases the frequency, rate or extent of a defense response.


positive regulation of response to biotic stimulus

Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.


B cell proliferation

The expansion of a B cell population by cell division. Follows B cell activation.


leukocyte proliferation

The expansion of a leukocyte population by cell division.


B cell activation involved in immune response

The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


mononuclear cell proliferation

The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.


lymphocyte proliferation

The expansion of a lymphocyte population by cell division.


SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1


SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 1


synaptic vesicle cycle

A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters.


synaptic vesicle endocytosis

A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.


protein depolymerization

The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.


synaptic vesicle recycling

The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane.


vesicle-mediated transport in synapse

Any vesicle-mediated transport that occurs in a synapse.


MEMBRANE-ASSOCIATED GUANYLATE KINASE  MAGUK


protein localization to cell junction

A process in which a protein is transported to, or maintained in, a location within a cell junction.


regulation of neurotransmitter secretion

Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.


HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H


EPITHELIAL SPLICING REGULATORY PROTEIN 1


HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H3


EPITHELIAL SPLICING REGULATORY PROTEIN 2


HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H2


HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN F


amino sugar metabolic process

The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group.


DYSTROBREVIN BINDING PROTEIN 1  DYSBINDIN


secretory granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.


synaptic vesicle transport

The directed movement of synaptic vesicles.


EMILIN  ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN   ELASTIN MICROFIBRIL INTERFACER


COMPLEMENT C1Q AND TUMOR NECROSIS FACTOR-RELATED PROTEIN 9B


COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 5


COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 2


COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 7


COMPLEMENT C1Q AND TUMOR NECROSIS FACTOR-RELATED PROTEIN 9A


BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE


BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1


BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2


LETHAL(2) GIANT LARVAE PROTEIN HOMOLOG 1


LLGL SCRIBBLE CELL POLARITY COMPLEX COMPONENT 2


cortical cytoskeleton

The portion of the cytoskeleton that lies just beneath the plasma membrane.


cortical actin cytoskeleton

The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.


regulation of protein secretion

Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.


regulation of protein transport

Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of establishment of protein localization

Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.


establishment of spindle orientation

Any process that set the alignment of spindle relative to other cellular structures.


regulation of establishment or maintenance of cell polarity

Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.


spindle localization

Any process in which is the spindle is transported to, and/or maintained in, a specific location.


establishment of spindle localization

The directed movement of the spindle to a specific location in the cell.


cortical cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.


cortical actin cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.


EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE  EIF2-ALPHA KINASE -RELATED


EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3


INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE


EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1


MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE


regulation of cell cycle G2/M phase transition

Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.


negative regulation of cell cycle G2/M phase transition

Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.


regulation of meiotic cell cycle

Any process that modulates the rate or extent of progression through the meiotic cell cycle.


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10D


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10C


extrinsic apoptotic signaling pathway via death domain receptors

The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.


apoptotic signaling pathway

The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.


extrinsic apoptotic signaling pathway

The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.


39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED


39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL


anaphase-promoting complex

A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.


cell division

The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.


positive regulation of organelle organization

Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.


positive regulation of cell cycle

Any process that activates or increases the rate or extent of progression through the cell cycle.


positive regulation of mitotic cell cycle

Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.


positive regulation of mitotic nuclear division

Any process that activates or increases the frequency, rate or extent of mitosis.


PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN


PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B


PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1C


PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1A


ribosomal subunit export from nucleus

The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.


ribosomal large subunit assembly

The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.


TRANSCRIPTION INITIATION FACTOR IIIC  TFIIIC , POLYPEPTIDE 3-RELATED


GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3


transcription factor TFIIIC complex

A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.


transcription by RNA polymerase III

The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.


clathrin binding

Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.


citrate transmembrane transporter activity

Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other.


mitochondrial transmembrane transport

The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.


citrate transport

The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


tricarboxylic acid transport

The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


DISTAL MEMBRANE-ARM ASSEMBLY COMPLEX PROTEIN 1


mitochondrial respiratory chain complex assembly

The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.


mitochondrial respiratory chain complex I assembly

The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.


C1GALT1-SPECIFIC CHAPERONE 1-LIKE PROTEIN


galactosyltransferase activity

Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED


MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 3


MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 4


MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 2


MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 1


Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway


hippo signaling

The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.


ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3


hormone activity

The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.


DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG  SUPPRESSIN


DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG


FAMILY WITH SEQUENCE SIMILARITY 241 MEMBER A


HIGH MOBILITY GROUP PROTEIN B1-LIKE 1-RELATED


calcium-dependent phospholipid binding

Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.


positive regulation of cytokine-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.


ERBB signaling pathway

The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED


CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1


CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR2


L-glutamate transmembrane transporter activity

Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.


acidic amino acid transmembrane transporter activity

Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3.


dicarboxylic acid transport

The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


acidic amino acid transport

The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


amide transport

The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


C4-dicarboxylate transport

The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.


very long-chain fatty acid metabolic process

The chemical reactions and pathways involving a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons.


TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10


TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6


TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 11


TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14


TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15


tumor necrosis factor receptor superfamily binding

Binding to a member of the tumor necrosis factor receptor superfamily.


SPERMATOGENESIS-ASSOCIATED PROTEIN 5-LIKE PROTEIN 1


TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE


peroxisomal membrane

The lipid bilayer surrounding a peroxisome.


peroxisome

A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.


microbody

Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).


modification-dependent protein binding

Binding to a protein upon post-translation modification of the target protein.


polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination of the target protein.


intracellular protein transmembrane transport

The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.