p-cumate biosynthetic process

The chemical reactions and pathways resulting in the formation of p-cumate.


L(+)-lactate biosynthetic process from pyruvate

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate.


dethiobiotin biosynthetic process

The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms.


methylgallate biosynthetic process

The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid.


dermatan sulfate biosynthetic process

The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.


lactate biosynthetic process from pyruvate

The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate.


mycolic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain.


positive regulation of fever generation by prostaglandin biosynthetic process

Any prostaglandin biosynthetic process process that positively_regulates fever generation.


aldonic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group.


2-oxobutyrate biosynthetic process

The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2.


butyrate biosynthetic process

The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid.


o-orsellinic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of o-orsellinic acid.


palmitic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of palmitic acid.


ochratoxin A biosynthetic process

The chemical reactions and pathways resulting in the formation of ochratoxin A.


glycyrrhetinate biosynthetic process

The chemical reactions and pathways resulting in the formation of glycyrrhetinate.


early stripe melanocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development).


late stripe melanocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development).


UDP-N-acetylgalactosamine transmembrane transporter activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


pyrazolylalanine synthase activity

Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O.


negative regulation of sorocarp stalk cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


regulation of sorocarp stalk cell differentiation

Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


positive regulation of sorocarp stalk cell differentiation

Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


cyclamate sulfohydrolase activity

Catalysis of the reaction: cyclohexylsulfamate + H2O = cyclohexylamine + sulfate.


heme B transmembrane transporter activity

Enables the transfer of heme B from one side of a membrane to the other.


3M complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity.


negative regulation of cholangiocyte proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation.


regulation of cholangiocyte proliferation

Any process that modulates the frequency, rate or extent of cholangiocyte proliferation.


fibrinogen complex

A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.


negative regulation of nucleoside transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


negative regulation of adenosine transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


negative regulation of purine nucleoside transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


negative regulation of inosine transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


negative regulation of octopamine signaling pathway involved in response to food

Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food.


negative regulation of octopamine signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway.


detection of light stimulus involved in magnetoreception

The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field.


detection of light stimulus involved in sensory perception

The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light.


detection of light stimulus involved in visual perception

The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.


exploration behavior

The specific behavior of an organism in response to a novel environment or stimulus.


locomotory exploration behavior

The specific movement from place to place of an organism in response to a novel environment.


sequestering of iron ion

The process of binding or confining iron ions such that they are separated from other components of a biological system.


extracellular sequestering of iron ion

The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system.


intracellular sequestering of iron ion

The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system.


tRNA-dihydrouridine47 synthase activity

Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) = H+ + a uracil47 in tRNA + NAD(P)H.


myosin II light chain binding

Binding to a light chain of a myosin II complex.


caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule.


spindle pole body localization

Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells.


amino disaccharide metabolic process

The chemical reactions and pathways involving any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions.


chitobiose metabolic process

The chemical reactions and pathways involving chitobioses, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine.


diacetylchitobiose metabolic process

The chemical reactions and pathways involving diacetylchitobiose, the N,N'-diacetylated derivative of chitobiose.


alkanesulfonate binding

Binding to alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.


positive regulation of striated muscle tissue development

Any process that activates or increases the frequency, rate or extent of striated muscle development.


positive regulation of muscle organ development

Any process that activates, maintains or increases the rate of muscle development.


positive regulation of cardiac muscle tissue development

Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development.


positive regulation of branchiomeric skeletal muscle development

Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure.


positive regulation of skeletal muscle tissue development

Any process that activates, maintains or increases the rate of skeletal muscle tissue development.


positive regulation of skeletal muscle fiber development

Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.


positive regulation of extraocular skeletal muscle development

Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle.


positive regulation of somitomeric trunk muscle development

Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle.


protein phosphorylated amino acid binding

Binding to a phosphorylated amino acid residue within a protein.


RNA polymerase II C-terminal domain phosphoserine binding

Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II.


phosphoserine residue binding

Binding to a phosphorylated serine residue within a protein.


phosphothreonine residue binding

Binding to a phosphorylated threonine residue within a protein.


phosphotyrosine residue binding

Binding to a phosphorylated tyrosine residue within a protein.


positive regulation of shade avoidance

Any process that activates or increases the frequency, rate or extent of shade avoidance.


regulation of shade avoidance

Any process that modulates the frequency, rate or extent of shade avoidance.


negative regulation of shade avoidance

Any process that stops, prevents or reduces the frequency, rate or extent of shade avoidance.


D-ornithine metabolic process

The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid.


RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity

Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) = RNA polymerase II large subunit trans-proline (omega=0).


RNA polymerase II CTD heptapeptide repeat P3 isomerase activity

Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 3) = RNA polymerase II large subunit trans-proline (omega=0) (position 3).


RNA polymerase II CTD heptapeptide repeat P6 isomerase activity

Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 6) = RNA polymerase II large subunit trans-proline (omega=0) (position 6).


NADH dehydrogenase complex (plastoquinone) assembly

The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I.


plus-end directed microtubule sliding

The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules.


FAD-dependent H3K4me/H3K4me3 demethylase activity

Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.


histone H3K4 demethylase activity

Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein.


histone H3K4me/H3K4me2/H3K4me3 demethylase activity

Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


positive regulation of NAD+ ADP-ribosyltransferase activity

Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.


regulation of NAD+ ADP-ribosyltransferase activity

Any process that modulates the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.


negative regulation of NAD+ ADP-ribosyltransferase activity

Any process that stops, prevents or reduces the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.


ribosylnicotinate kinase activity

Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide.


paraflagellar rod assembly

The aggregation, arrangement and bonding together of a set of components to form a paraflagellar rod, a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme.


sperm flagellum assembly

The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium).


cytosolic ciliogenesis

The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm.


detection of glucose

The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal.


response to monosaccharide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus.


detection of hexose stimulus

The series of events in which a stimulus from a hexose is received and converted into a molecular signal.


cellular response to fructose stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus.


cellular response to glyceraldehyde

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus.


response to D-galactose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus.


detection of monosaccharide stimulus

The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal.


response to mannose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus.


cellular response to hexose stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.


response to glyceraldehyde

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus.


cellular response to D-galactose

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus.


cellular response to monosaccharide stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus.


cellular response to mannose

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus.


response to hexose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.


response to rhamnose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus.


cellular response to rhamnose stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus.


response to fructose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus.


cellular response to glucose stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.


histidine-tRNA ligase activity

Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).


subapical part of cell

The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina.


adrenomedullin binding

Binding to adrenomedullin (AM).


ubiquitin activating enzyme binding

Binding to a ubiquitin activating enzyme, any of the E1 proteins.


myosin III binding

Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain.


prostaglandin D2 receptor binding

Binding to a prostaglandin D2 receptor.


type 2 neuromedin U receptor binding

Binding to a type 2 neuromedin U receptor.


leukotriene receptor binding

Binding to a leukotriene receptor.


SH2 domain binding

Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.


cysteinyl leukotriene receptor binding

Binding to a cysteinyl leukotriene receptor.


insulin binding

Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.


actin lateral binding

Binding to an actin filament along its length.


activin receptor binding

Binding to an activin receptor.


phosphatidylinositol 3-kinase catalytic subunit binding

Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.


laminin receptor activity

Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity.


B1 bradykinin receptor binding

Binding to a B1 bradykinin receptor.


intramolecular proline-rich ligand binding

Binding to a proline-rich region within the same polypeptide.


sumo-dependent protein binding

Binding to a protein upon sumoylation of the target protein.


alpha-1D adrenergic receptor binding

Binding to an alpha-1D adrenergic receptor.


RING-like zinc finger domain binding

Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain.


insulin-like growth factor receptor binding

Binding to an insulin-like growth factor receptor.


vinculin binding

Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.


receptor tyrosine kinase-like orphan receptor binding

Binding to a receptor tyrosine kinase-like orphan receptor (Ror).


NACHT domain binding

Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg2+-binding site and five more specific motifs.


adipokinetic hormone binding

Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


glutamate-cysteine ligase catalytic subunit binding

Binding to the catalytic subunit of glutamate-cysteine ligase.


type 4 proteinase activated receptor binding

Binding to a type 4 proteinase activated receptor.


HDEL sequence binding

Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.


haptoglobin binding

Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex.


type 6 serotonin receptor binding

Binding to a type 6 serotonin receptor.


C3HC4-type RING finger domain binding

Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway.


type 2B serotonin receptor binding

Binding to a type 2B serotonin receptor.


interleukin-9 binding

Binding to interleukin-9.


CD4 receptor binding

Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages.


type 2 metabotropic GABA receptor binding

Binding to a type 2 metabotropic GABA receptor.


MIT domain binding

Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking.


protein phosphatase 5 binding

Binding to protein phosphatase 5.


type 1 cannabinoid receptor binding

Binding to a type 1 cannabinoid receptor.


GAF domain binding

Binding to a GAF protein domain.


very-low-density lipoprotein particle binding

Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.


protein phosphatase 1 binding

Binding to a protein phosphatase 1.


14-3-3 protein binding

Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.


syndecan binding

Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.


protein binding involved in heterotypic cell-cell adhesion

Binding to a protein or protein complex contributing to the adhesion of two different types of cells.


sevenless binding

Binding to a sevenless (sev) protein, a receptor tyrosine kinase.


MHC class Ib protein binding

Binding to a major histocompatibility complex class Ib molecules.


type 1 fibroblast growth factor receptor binding

Binding to a type 1 fibroblast growth factor receptor (FGFR1).


Edg-2 lysophosphatidic acid receptor binding

Binding to an Edg-2 lysophosphatidic acid receptor.


type-I cohesin domain binding

Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain.


complement component C5a binding

Binding to a C5a product of the complement cascade.


type 2 somatostatin receptor binding

Binding to a type 2 somatostatin receptor.


substance P receptor binding

Binding to a substance P receptor.


G-protein alpha-subunit binding

Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.


type A cholecystokinin receptor binding

Binding to a type A cholecystokinin receptor.


dynein intermediate chain binding

Binding to an intermediate chain of the dynein complex.


myosin II heavy chain binding

Binding to a heavy chain of a myosin II complex.


type 1 angiotensin receptor binding

Binding to a type 1 angiotensin receptor.


LIM domain binding

Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.


amylin binding

Binding to amylin.


receptor-receptor interaction

The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.


Toll-like receptor 2 binding

Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.


troponin T binding

Binding to troponin T, the tropomyosin-binding subunit of the troponin complex.


complement component iC3b binding

Binding to a iC3b product of the complement cascade.


type 2 neuropeptide Y receptor binding

Binding to a type 2 neuropeptide Y receptor.


D4 dopamine receptor binding

Binding to a D4 dopamine receptor.


CARD domain binding

Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.


apolipoprotein A-I binding

Binding to apolipoprotein A-I.


alpha-2B adrenergic receptor binding

Binding to an alpha-2B adrenergic receptor.


TFIIE-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


preprotein binding

Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing.


interleukin-21 binding

Binding to interleukin-21.


interleukin-12 binding

Binding to interleukin-12.


hemoglobin beta binding

Binding to a hemoglobin beta chain.


proteinase activated receptor binding

Binding to a proteinase activated receptor.


SOCS family protein binding

Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions.


MHC class Ib protein binding, via antigen binding groove

Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove.


GTP cyclohydrolase binding

Binding to a GTP cyclohydrolase.


P2Y10 nucleotide receptor binding

Binding to a P2Y10 nucleotide receptor.


adiponectin binding

Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism.


co-receptor binding

Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell.


K48-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.


P2Y8 nucleotide receptor binding

Binding to a P2Y8 nucleotide receptor.


complement component C4b binding

Binding to a C4b product of the classical complement cascade.


thromboxane A2 receptor binding

Binding to a thromboxane A2 receptor.


ephrin receptor binding

Binding to an ephrin receptor.


G protein-coupled glutamate receptor binding

Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor).


type-II cohesin domain binding

Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain.


type 1 somatostatin receptor binding

Binding to a type 1 somatostatin receptor.


corticotropin-releasing hormone receptor binding

Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.


diacyl lipopeptide binding

Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups.


G protein-coupled histamine receptor binding

Binding to a G protein-coupled (metabotropic) histamine receptor.


ErbB-3 class receptor binding

Binding to the protein-tyrosine kinase receptor ErbB-3/HER3.


myosin I tail binding

Binding to the tail region of a myosin I heavy chain.


myosin XI tail binding

Binding to the tail region of a myosin XI heavy chain.


TIR domain binding

Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components.


phospholipase binding

Binding to a phospholipase.


kringle domain binding

Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors.


interleukin-26 binding

Binding to interleukin-26.


semaphorin receptor binding

Binding to a semaphorin receptor.


beta-endorphin receptor binding

Binding to a beta-endorphin receptor.


interleukin-11 binding

Binding to interleukin-11.


RNA polymerase III general transcription initiation factor binding

Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III.


myosin II binding

Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.


type 1B melatonin receptor binding

Binding to a type 1B melatonin receptor.


type B gastrin/cholecystokinin receptor binding

Binding to a type B gastrin/cholecystokinin receptor.


glutamate receptor binding

Binding to a glutamate receptor.


hexon binding

Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus.


P2Y6 nucleotide receptor binding

Binding to a P2Y6 nucleotide receptor.


BMP receptor binding

Binding to a BMP receptor.


endoplasmic reticulum signal peptide binding

Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.


type 1 cysteinyl leukotriene receptor binding

Binding to a type 1 cysteinyl leukotriene receptor.


G protein-coupled acetylcholine receptor binding

Binding to a G protein-coupled acetylcholine receptor.


denatured protein binding

Binding to a denatured protein.


urotensin receptor binding

Binding to a urotensin receptor.


eukaryotic initiation factor 4E binding

Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.


p53 binding

Binding to one of the p53 family of proteins.


TFIIA-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.


interleukin-23 binding

Binding to interleukin-23.


chemokine (C-C motif) ligand 21 binding

Binding to chemokine (C-C motif) ligand 21.


neuromedin K receptor binding

Binding to a neuromedin K receptor.


glycosylated region protein binding

Binding to a glycosylated region of a protein.


alpha-1A adrenergic receptor binding

Binding to an alpha-1A adrenergic receptor.


beta-3 adrenergic receptor binding

Binding to a beta-3 adrenergic receptor.


ganglioside binding

Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues.


acrosin binding

Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities.


V2 vasopressin receptor binding

Binding to a V2 vasopressin receptor.


H3 histamine receptor binding

Binding to a H3 histamine receptor.


cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication

Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.


type 4 metabotropic glutamate receptor binding

Binding to a type 4 metabotropic glutamate receptor.


MHC class I protein binding, via antigen binding groove

Binding to a major histocompatibility complex class I molecules via the antigen binding groove.


type I interferon binding

Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.


myosin I heavy chain binding

Binding to a heavy chain of a myosin I complex.


alpha-catenin binding

Binding to catenin complex alpha subunit.


type 1 melanocortin receptor binding

Binding to a type 1 melanocortin receptor.


hemoglobin binding

Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


troponin I binding

Binding to troponin I, the inhibitory subunit of the troponin complex.


adrenergic receptor binding

Binding to an adrenergic receptor.


zf-TRAF domain binding

Binding to a TRAF-type zinc finger domain of a protein.


lipase binding

Binding to a lipase.


G-protein gamma-subunit binding

Binding to a G-protein gamma subunit.


interferon binding

Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent.


cytoskeletal regulatory protein binding

Binding to a protein involved in modulating the reorganization of the cytoskeleton.


Edg-6 sphingosine 1-phosphate receptor binding

Binding to an Edg-6 sphingosine 1-phosphate receptor.


prostanoid receptor binding

Binding to a prostanoid receptor.


interleukin-22 binding

Binding to interleukin-22.


plastid single-subunit type RNA polymerase binding

Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


insulin-like growth factor I binding

Binding to insulin-like growth factor I.


TFIIIB-class transcription factor complex binding

Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.


TFIIIC-class transcription factor complex binding

Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.


C2 domain binding

Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes.


cholecystokinin receptor binding

Binding to a cholecystokinin receptor.


talin binding

Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types.


type 2 metabotropic glutamate receptor binding

Binding to a type 2 metabotropic glutamate receptor.


interleukin-20 binding

Binding to interleukin-20.


low-density lipoprotein particle receptor binding

Binding to a low-density lipoprotein receptor.


TAP1 binding

Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein.


prolactin-releasing peptide receptor binding

Binding to a prolactin-releasing peptide receptor.


type I activin receptor binding

Binding to a type I activin receptor.


glycosylation-dependent protein binding

Binding to a protein upon glycosylation of the target protein.


BH1 domain binding

Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists.


EP3 subtype prostaglandin E2 receptor binding

Binding to an EP3 subtype prostaglandin E2 receptor.


type III interferon binding

Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far.


ATPase binding

Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.


protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.


peptidyl-proline 4-dioxygenase binding

Binding to a peptidyl-proline 4-dioxygenase.


Edg-4 lysophosphatidic acid receptor binding

Binding to an Edg-4 lysophosphatidic acid receptor.


mitochondrial single-subunit type RNA polymerase binding

Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


chemokine (C-C motif) ligand 7 binding

Binding to chemokine (C-C motif) ligand 7.


RNA polymerase II complex recruiting activity

Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.


protein phosphatase 2A binding

Binding to protein phosphatase 2A.


high-density lipoprotein particle receptor binding

Binding to a high-density lipoprotein receptor.


CH domain binding

Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins.


cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.


vacuolar sorting signal binding

Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole.


interleukin-19 binding

Binding to interleukin-19.


C-X3-C chemokine binding

Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.


collectin binding

Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus.


type 1 metabotropic glutamate receptor binding

Binding to a type 1 metabotropic glutamate receptor.


secretin receptor binding

Binding to a secretin receptor.


RBL family protein binding

Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose.


PDZ domain binding

Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.


opioid receptor binding

Binding to an opioid receptor.


calcitonin binding

Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid.


cyclosporin A binding

Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.


neuromedin U receptor binding

Binding to one or more specific sites on a neuromedin U receptor.


K6-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein.


eukaryotic initiation factor 4G binding

Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.


interleukin-18 binding

Binding to interleukin-18.


P2Y11 nucleotide receptor binding

Binding to a P2Y11 nucleotide receptor.


MDA-5 binding

Binding to MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA.


cargo receptor ligand activity

The activity of a gene product that interacts with a cargo receptor and initiates endocytosis.


Binding to a protein upon phosphorylation of the target protein.


type 1 metabotropic GABA receptor binding

Binding to a type 1 metabotropic GABA receptor.


type 2C serotonin receptor binding

Binding to a type 2C serotonin receptor.


melanin-concentrating hormone receptor binding

Binding to a melanin-concentrating hormone receptor.


Edg-1 sphingosine 1-phosphate receptor binding

Binding to an Edg-1 sphingosine 1-phosphate receptor.


K11-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein.


type 5B serotonin receptor binding

Binding to a type 5B serotonin receptor.


neuromedin U binding

Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses.


apolipoprotein binding

Binding to an apolipoprotein, the protein component of a lipoprotein complex.


gonadotropin-releasing hormone receptor binding

Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.


type 1 neuromedin U receptor binding

Binding to a type 1 neuromedin U receptor.


platelet activating factor receptor binding

Binding to a platelet activating factor receptor.


nuclear vitamin D receptor binding

Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.


parathyroid hormone receptor binding

Binding to a parathyroid hormone receptor.


death effector domain binding

Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).


nuclear mineralocorticoid receptor binding

Binding to a nuclear mineralocorticoid receptor.


V1A vasopressin receptor binding

Binding to a V1A vasopressin receptor.


transcription corepressor binding

Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.


FFAT motif binding

Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.


virus receptor activity

Combining with a virus component and mediating entry of the virus into the cell.


bombesin receptor binding

Binding to a bombesin receptor.


angiostatin binding

Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis.


macrophage migration inhibitory factor binding

Binding to the cytokine, macrophage migration inhibitory factor.


exogenous protein binding

Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein.


granulocyte macrophage colony-stimulating factor complex binding

Binding to a granulocyte macrophage colony-stimulating factor complex.


corticotropin-releasing hormone binding

Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.


nitric-oxide synthase binding

Binding to nitric-oxide synthase.


pentraxin binding

Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array.


A2B adenosine receptor binding

Binding to an A2B adenosine receptor.


myosin V binding

Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.


cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication

Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells.


bacterial-type RNA polymerase core enzyme binding

Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit.


high molecular weight B cell growth factor receptor binding

Binding to a high molecular weight B cell growth factor receptor.


TFIIH-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


STAT family protein binding

Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.


Hsp27 protein binding

Binding to Hsp27 proteins, a lightweight heat shock protein.


BIR domain binding

Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain.


titin binding

Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.


connexin binding

Binding to a connexin, any of a group of related proteins that assemble to form gap junctions.


spectrin binding

Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.


RNA polymerase II C-terminal domain binding

Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function.


interleukin-12 alpha subunit binding

Binding to the alpha subunit of interleukin-12.


prostacyclin receptor binding

Binding to a prostacyclin receptor.


chloroplast targeting sequence binding

Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.


nuclear retinoid X receptor binding

Binding to a nuclear retinoid X receptor.


interleukin-13 binding

Binding to interleukin-13.


nodal binding

Binding to a nodal protein, a member of the transforming growth factor-beta superfamily.


cell adhesion receptor activity

The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins.


Fc-gamma receptor I complex binding

Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.


transferrin receptor binding

Binding to a transferrin receptor.


EP2 subtype prostaglandin E2 receptor binding

Binding to an EP2 subtype prostaglandin E2 receptor.


somatostatin binding

Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin.


chondroitin sulfate proteoglycan binding

Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.


fMet-Leu-Phe receptor binding

Binding to a fMet-Leu-Phe receptor.


MHC class II protein binding, via lateral surface

Binding to the lateral surface of major histocompatibility complex class II molecules.


scavenger receptor binding

Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.


type 6 metabotropic glutamate receptor binding

Binding to a type 6 metabotropic glutamate receptor.


D3 dopamine receptor binding

Binding to a D3 dopamine receptor.


laminin-1 binding

Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.


type 7 metabotropic glutamate receptor binding

Binding to a type 7 metabotropic glutamate receptor.


DH domain binding

Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.


alpha-2C adrenergic receptor binding

Binding to an alpha-2C adrenergic receptor.


CD8 receptor binding

Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.


SUMO binding

Binding to the small ubiquitin-like protein SUMO.


type 1 orexin receptor binding

Binding to a type 1 orexin receptor.


muscle alpha-actinin binding

Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.


tropomyosin binding

Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.


complement component C3d binding

Binding to a C3d product of the complement cascade.


aryl hydrocarbon receptor binding

Binding to an aryl hydrocarbon receptor.


translation elongation factor binding

Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation.


protein heterodimerization activity

Binding to a nonidentical protein to form a heterodimer.


single-subunit type RNA polymerase binding

Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


insulin-like growth factor II binding

Binding to insulin-like growth factor II.


interleukin-27 binding

Binding to interleukin-27.


TFIIB-class transcription factor binding

Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


type 1B serotonin receptor binding

Binding to a type 1B serotonin receptor.


tapasin binding

Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules.


opsin binding

Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception.


Edg-7 lysophosphatidic acid receptor binding

Binding to an Edg-7 lysophosphatidic acid receptor.


leucine zipper domain binding

Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.


arrestin family protein binding

Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.


lysine-acetylated histone binding

Binding to a histone in which a lysine residue has been modified by acetylation.


patched binding

Binding to a patched (ptc) protein, a receptor for hedgehog proteins.


dynein light chain binding

Binding to a light chain of the dynein complex.


calcium-dependent protein binding

Binding to a protein or protein complex in the presence of calcium.


type 1 neurotensin receptor binding

Binding to a type 1 neurotensin receptor.


myosin tail binding

Binding to the tail region of a myosin heavy chain.


type-III cohesin domain binding

Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain.


nuclear retinoic acid receptor binding

Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.


epidermal growth factor binding

Binding to epidermal growth factor.


endothelial differentiation G protein-coupled receptor binding

Binding to an endothelial differentiation G protein-coupled receptor.


peroxisome membrane class-2 targeting sequence binding

Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner.


penicillin binding

Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.


TFIIIA-class transcription factor binding

Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters.


DNA binding domain binding

Binding to a protein's DNA binding domain (DBD).


neuroligin family protein binding

Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.


ADP-D-ribose modification-dependent protein binding

Binding to a protein upon ADP-ribosylation of the target protein.


ciliary neurotrophic factor binding

Binding to the cytokine ciliary neurotrophic factor.


orexin receptor binding

Binding to an orexin receptor.


zymogen binding

Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.


gamma-catenin binding

Binding to catenin complex gamma subunit.


EP4 subtype prostaglandin E2 receptor binding

Binding to an EP4 subtype prostaglandin E2 receptor.


FYXD domain binding

Binding to a FXYD domain.


calcium-dependent outer dynein arm binding

Binding to an outer dynein arm in the presence of calcium.


interleukin-33 binding

Binding to interleukin-33.


triacyl lipopeptide binding

Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups.


SAM domain binding

Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes.


peroxisome matrix targeting signal-2 binding

Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F).


glial cell-derived neurotrophic factor receptor binding

A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors.


GBD domain binding

Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.


proctolin receptor binding

Binding to a proctolin receptor.


MHC class I protein binding

Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


insulin-like growth factor binding

Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.


T cell receptor binding

Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells.


hepatocyte growth factor binding

Binding to a hepatocyte growth factor.


Tat protein binding

Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus.


H9 melatonin receptor binding

Binding to a H9 melatonin receptor.


glucagon receptor binding

Binding to a glucagon receptor.


PH domain binding

Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.


type 1 member 3 taste receptor binding

Binding to a type 1 member 3 taste receptor.


myosin VI light chain binding

Binding to a light chain of a myosin VI complex.


beta-2-microglobulin binding

Binding to beta-2-microglobulin.


endocytic targeting sequence binding

Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits.


MATH domain binding

Binding to a meprin and TRAF homology (MATH) domain.


interleukin-8 binding

Binding to interleukin-8.


intercellular adhesion molecule-3 receptor binding

Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1.


cell adhesive protein binding involved in AV node cell-bundle of His cell communication

Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells.


extracellular matrix protein binding

Binding to a protein that is part of an extracellular matrix.


H2 histamine receptor binding

Binding to a H2 histamine receptor.


corazonin receptor binding

Binding to a corazonin receptor.


myosin VI heavy chain binding

Binding to a heavy chain of a myosin VI complex.


MH2 domain binding

Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.


nuclear localization sequence binding

Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.


hedgehog family protein binding

Binding to a member of the hedgehog protein family, signaling proteins involved in development.


RIP homotypic interaction motif binding

Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases.


interleukin-10 binding

Binding to interleukin-10.


ErbB-4 class receptor binding

Binding to the protein-tyrosine kinase receptor ErbB-4/HER4.


nuclear glucocorticoid receptor binding

Binding to a nuclear glucocorticoid receptor.


V1B vasopressin receptor binding

Binding to a V1B vasopressin receptor.


cAMP response element binding protein binding

Binding to a cAMP response element binding protein (a CREB protein).


filamin binding

Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.


MADS box domain binding

Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs.


type 1 member 1 taste receptor binding

Binding to a type 1 member 1 taste receptor.


low molecular weight kininogen binding

Binding to a kininogen of low molecular mass.


peptide hormone receptor binding

Binding to a receptor for a peptide hormone.


type 7 serotonin receptor binding

Binding to a type 7 serotonin receptor.


proteoglycan binding

Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


neuropeptide F receptor binding

Binding to a neuropeptide F receptor.


acetylation-dependent protein binding

Binding to a protein upon acetylation of the target protein.


beta-2 adrenergic receptor binding

Binding to a beta-2 adrenergic receptor.


CRD domain binding

Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins.


death domain binding

Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.


importin-alpha family protein binding

Binding to a member of the importin-alpha family.


neurotrophin binding

Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.


nuclear cortisol receptor binding

Binding to a nuclear cortisol receptor.


chemokine (C-C motif) ligand 12 binding

Binding to chemokine (C-C motif) ligand 12.


type 4 neuropeptide Y receptor binding

Binding to a type 4 neuropeptide Y receptor.


linear polyubiquitin binding

Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next.


actinin binding

Binding to actinin, any member of a family of proteins that crosslink F-actin.


prostaglandin F2-alpha receptor binding

Binding to a prostaglandin F2-alpha receptor.


farnesylated protein binding

Binding to a farnesylated protein.


pituitary adenylate cyclase-activating polypeptide receptor binding

Binding to a pituitary adenylate cyclase-activating polypeptide receptor.


gastric inhibitory polypeptide receptor binding

Binding to a gastric inhibitory polypeptide receptor.


Rho GDP-dissociation inhibitor binding

Binding to a Rho GDP-dissociation inhibitor protein.


myosin II head/neck binding

Binding to the head/neck region of a myosin II heavy chain.


ubiquitin-specific protease binding

Binding to a ubiquitin-specific protease.


type-II dockerin domain binding

Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain.


RAGE receptor binding

Binding to a RAGE receptor, the receptor for advanced glycation end-products.


interleukin-17 binding

Binding to a member of the interleukin-17 family of cytokines.


laminin binding involved in cell-matrix adhesion

Any laminin protein binding that occurs as part of cell-matrix adhesion.


olfactory receptor binding

Binding to an olfactory receptor.


orexigenic neuropeptide QRFP receptor binding

Binding to an orexigenic neuropeptide QRFP receptor.


ciliary targeting signal binding

Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane.


thioesterase binding

Binding to a thioesterase.


gonadotropin-releasing hormone binding

Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


A3 adenosine receptor binding

Binding to an A3 adenosine receptor.


poly-ADP-D-ribose modification-dependent protein binding

Binding to a protein upon poly-ADP-ribosylation of the target protein.


angiotensin receptor binding

Binding to an angiotensin receptor.


subtype 3 bombesin receptor binding

Binding to a subtype 3 bombesin receptor.


delta-catenin binding

Binding to the delta subunit of the catenin complex.


DNA polymerase binding

Binding to a DNA polymerase.


immunoglobulin receptor binding

Binding to one or more specific sites on an immunoglobulin receptor molecule.


thioglucosidase binding

Binding to a thioglucosidase enzyme.


Krueppel-associated box domain binding

Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.


Rel homology domain binding

Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT.


urea binding

Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2.


endothelin B receptor binding

Binding to an endothelin B receptor.


DDEL sequence binding

Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.


oxytocin receptor binding

Binding to an oxytocin receptor.


type 3 melanocortin receptor binding

Binding to a type 3 melanocortin receptor.


insulin receptor substrate binding

Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.


type 4 melanocortin receptor binding

Binding to a type 4 melanocortin receptor.


kisspeptin receptor binding

Binding to a kisspeptin receptor.


type 1D serotonin receptor binding

Binding to a type 1D serotonin receptor.


caspase binding

Binding to a caspase family protein.


H3K27me3 modified histone binding

Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation.


kininogen binding

Binding to a kininogen, a kinin precursor.


high mobility group box 1 binding

Binding to high mobility group box 1 (HMBGB1).


adrenomedullin receptor binding

Binding to an adrenomedullin receptor.


type 1 melanin-concentrating hormone receptor binding

Binding to a type 1 melanin-concentrating hormone receptor.


LEM domain binding

Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF).


transcription coregulator binding

Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.


syntaxin-3 binding

Binding to a syntaxin-3 SNAP receptor.


thyrotropin-releasing hormone receptor binding

Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary.


S100 protein binding

Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.


CAP-Gly domain binding

Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets.


histone methyltransferase binding

Binding to a histone methyltransferase enzyme.


vasopressin receptor binding

Binding to a vasopressin receptor.


MHC class I protein binding, via lateral surface

Binding to a major histocompatibility complex class I molecules via the lateral surface.


EGF repeat binding

Binding to Epidermal Growth Factor (EGF) repeats.


type 2 vasoactive intestinal polypeptide receptor binding

Binding to a type 2 vasoactive intestinal polypeptide receptor.


protein phosphatase 2B binding

Binding to a protein phosphatase 2B.


apolipoprotein A-I receptor binding

Binding to an apolipoprotein A-I receptor.


mu-type opioid receptor binding

Binding to a mu-type opioid receptor.


type 5 metabotropic glutamate receptor binding

Binding to a type 5 metabotropic glutamate receptor.


insulin receptor binding

Binding to an insulin receptor.


interleukin-25 binding

Binding to interleukin-25.


cannabinoid receptor binding

Binding to a cannabinoid receptor.


cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication

Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells.


ankyrin binding

Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.


P2Y2 nucleotide receptor binding

Binding to a P2Y2 nucleotide receptor.


type 3 galanin receptor binding

Binding to a type 3 galanin receptor.


SMC family protein binding

Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization.


titin Z domain binding

Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.


AF-1 domain binding

Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor.


type 5 somatostatin receptor binding

Binding to a type 5 somatostatin receptor.


SUMO polymer binding

Binding to a polymer of the small ubiquitin-like protein SUMO.


ubiquitin conjugating enzyme binding

Binding to a ubiquitin conjugating enzyme, any of the E2 proteins.


CD70 receptor binding

Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells.


C2H2 zinc finger domain binding

Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.


nuclear thyroid hormone receptor binding

Binding to a nuclear thyroid hormone receptor.


scaffold protein binding

Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.


myosin VI binding

Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.


imaginal disc growth factor receptor binding

Binding to an imaginal disc growth factor receptor.


proline-rich region binding

Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.


oligopeptide binding

Binding to an oligopeptide.


neuregulin binding

Binding to a neuregulin, a member of the EGF family of growth factors.


neuropeptide receptor binding

Binding to a neuropeptide receptor.


clathrin heavy chain binding

Binding to a clathrin heavy chain.


galanin receptor binding

Binding to a galanin receptor.


ubiquitin modification-dependent histone binding

Binding to a histone protein in which a residue has been modified by ubiquitination.


laminin binding

Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells.


bradykinin receptor binding

Binding to a bradykinin receptor.


smoothened binding

Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals.


Toll binding

Binding to a Toll protein, a transmembrane receptor.


Pyrin domain binding

Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain.


chemokine (C-C motif) ligand 19 binding

Binding to chemokine (C-C motif) ligand 19.


corticotropin hormone receptor binding

Binding to a corticotropin hormone receptor.


POU domain binding

Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors.


Notch binding

Binding to a Notch (N) protein, a surface receptor.


NFAT protein binding

Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.


myosin light chain binding

Binding to a light chain of a myosin complex.


C5a anaphylatoxin chemotactic receptor binding

Binding to a C5a anaphylatoxin chemotactic receptor.


telethonin binding

Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.


Edg-3 sphingosine 1-phosphate receptor binding

Binding to an Edg-3 sphingosine 1-phosphate receptor.


TFIIF-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


GTP-dependent protein binding

Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state.


RNA polymerase I general transcription initiation factor binding

Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I.


type 8 metabotropic glutamate receptor binding

Binding to a type 8 metabotropic glutamate receptor.


eukaryotic initiation factor eIF2 binding

Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation.


complement component C3b binding

Binding to a C3b product of the complement cascade.


ubiquitin-like protein binding

Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.


type 3 proteinase activated receptor binding

Binding to a type 3 proteinase activated receptor.


frizzled binding

Binding to a frizzled (fz) receptor.


follicle-stimulating hormone receptor binding

Binding to a follicle-stimulating hormone receptor.


H4 histamine receptor binding

Binding to a H4 histamine receptor.


apelin receptor binding

Binding to an apelin receptor.


ceramide binding

Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes.


type 5 neuropeptide Y receptor binding

Binding to a type 5 neuropeptide Y receptor.


growth hormone-releasing hormone receptor binding

Binding to a growth hormone-releasing hormone receptor.


RIG-I binding

Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.


nuclear progesterone receptor binding

Binding to a nuclear progesterone receptor.


C5L2 anaphylatoxin chemotactic receptor binding

Binding to a C5L2 anaphylatoxin chemotactic receptor.


phosphorylated histone binding

Binding to a histone in which a residue has been modified by phosphorylation.


protein domain specific binding

Binding to a specific domain of a protein.


troponin C binding

Binding to troponin C, the calcium-binding subunit of the troponin complex.


ErbB-2 class receptor binding

Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2.


microtubule lateral binding

Binding to the side of a microtubule.


lipopeptide binding

Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids.


HECT domain binding

Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein.


phytochrome binding

Binding to a phytochrome.


ATP-dependent protein binding

Binding to a protein or protein complex using energy from ATP hydrolysis.


myosin VI head/neck binding

Binding to the head/neck region of a myosin VI heavy chain.


apolipoprotein receptor binding

Binding to an apolipoprotein receptor.


poly-glutamine tract binding

Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein.


interleukin-7 binding

Binding to interleukin-7.


methylation-dependent protein binding

Binding to a protein upon methylation of the target protein.


type 1 member 2 taste receptor binding

Binding to a type 1 member 2 taste receptor.


adenylate cyclase binding

Binding to an adenylate cyclase.


peroxisome matrix targeting signal-1 binding

Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L.


cell adhesion mediator activity

The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.


G-protein beta-subunit binding

Binding to a G-protein beta subunit.


RHG protein domain binding

Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif).


LBD domain binding

Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket.


type 2 melanin-concentrating hormone receptor binding

Binding to a type 2 melanin-concentrating hormone receptor.


clathrin adaptor activity

Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles.


phosphatidylinositol 3-kinase regulatory subunit binding

Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.


interleukin-12 beta subunit binding

Binding to the beta subunit of interleukin-12.


muramyl dipeptide binding

Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan.


heparan sulfate proteoglycan binding

Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.


brain-derived neurotrophic factor binding

Binding to brain-derived neurotrophic factor.


D5 dopamine receptor binding

Binding to a D5 dopamine receptor.


type 2 galanin receptor binding

Binding to a type 2 galanin receptor.


interleukin-3 binding

Binding to interleukin-3.


A1 adenosine receptor binding

Binding to an A1 adenosine receptor.


PTB domain binding

Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain.


chromo shadow domain binding

Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.


very-low-density lipoprotein particle receptor binding

Binding to a very-low-density lipoprotein receptor.


sulfonylurea receptor binding

Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel.


peroxisome proliferator activated receptor binding

Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma.


BH domain binding

Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains.


FH1 domain binding

Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain.


type 1F serotonin receptor binding

Binding to a type 1F serotonin receptor.


FK506 binding

Binding to a 23-membered macrolide lactone FK506.


FMN-binding domain binding

Binding to the FMN-binding domain of a protein.


type 5 melanocortin receptor binding

Binding to a type 5 melanocortin receptor.


H4K20me3 modified histone binding

Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation.


D1 dopamine receptor binding

Binding to a D1 dopamine receptor.


myosin I binding

Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments.


C-X-C chemokine binding

Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif.


plastid PEP RNA polymerase core enzyme binding

Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit.


P2Y1 nucleotide receptor binding

Binding to a P2Y1 nucleotide receptor.


transmembrane receptor protein serine/threonine kinase binding

Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity.


type 4 serotonin receptor binding

Binding to a type 4 serotonin receptor.


sterol-dependent protein binding

Binding to a protein or protein complex in the presence of sterols.


GDP-dissociation inhibitor binding

Binding to a GDP-dissociation inhibitor protein.


high molecular weight kininogen receptor binding

Binding to a high molecular weight kininogen receptor.


co-SMAD binding

Binding to a common mediator SMAD signaling protein.


MHC class II protein binding

Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


tau protein binding

Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.


TAP2 binding

Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein.


bone sialoprotein binding

Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin.


neuropilin binding

Binding to a member of the neuropilin family.


glucagon family peptide binding

Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP).


motilin receptor binding

Binding to a motilin receptor.


hepatocyte growth factor receptor binding

Binding to an hepatocyte growth factor receptor.


tachykinin receptor binding

Binding to a tachykinin receptor.


phosphopantetheine binding

Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate).


AF-2 domain binding

Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation.


GTPase binding

Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP.


interleukin-24 binding

Binding to interleukin-24.


endothelin A receptor binding

Binding to an endothelin A receptor.


nerve growth factor binding

Binding to nerve growth factor (NGF).


lamin binding

Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.


neurokinin receptor binding

Binding to a neurokinin receptor.


beta-1 adrenergic receptor binding

Binding to a beta-1 adrenergic receptor.


ghrelin receptor binding

Binding to a ghrelin receptor.


neuropeptide Y receptor binding

Binding to a neuropeptide Y receptor.


delta-type opioid receptor binding

Binding to a delta-type opioid receptor.


myosin II tail binding

Binding to the tail region of a myosin II heavy chain.


type 2A serotonin receptor binding

Binding to a type 2A serotonin receptor.


taste receptor binding

Binding to a taste receptor.


F-bar domain binding

Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins.


interleukin-2 binding

Binding to interleukin-2.


gastrin-releasing peptide receptor binding

Binding to a gastrin-releasing peptide receptor.


neurotensin receptor binding

Binding to a neurotensin receptor.


nociceptin receptor binding

Binding to a nociceptin receptor.


corticotropin-releasing hormone receptor 1 binding

Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.


interleukin-5 binding

Binding to interleukin-5.


type 1 parathyroid hormone receptor binding

Binding to a type 1 parathyroid hormone receptor.


TRAIL binding

Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines.


lutropin-choriogonadotropic hormone receptor binding

Binding to a lutropin-choriogonadotropic hormone receptor.


lipoamide binding

Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.


type 1 proteinase activated receptor binding

Binding to a type 1 proteinase activated receptor.


serpin family protein binding

Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors.


dynein heavy chain binding

Binding to a heavy chain of the dynein complex.


adipokinetic hormone receptor binding

Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


ubiquitin-dependent protein binding

Binding to a protein upon ubiquitination of the target protein.


alpha-latrotoxin receptor binding

Binding to an alpha-latrotoxin receptor.


leptin receptor binding

Binding to a leptin receptor.


platelet-derived growth factor receptor binding

Binding to a platelet-derived growth factor receptor.


CD154 receptor binding

Binding to CD154, a receptor found on the surface of some activated lymphocytes.


misfolded protein binding

Binding to a misfolded protein.


deaminase binding

Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3).


dynein light intermediate chain binding

Binding to a light intermediate chain of the dynein complex.


ganglioside GM3 binding

Binding to ganglioside GM3.


torso binding

Binding to a torso (tor) protein, a receptor tyrosine kinase.


type 2 orexin receptor binding

Binding to a type 2 orexin receptor.


BH4 domain binding

Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein.


B2 bradykinin receptor binding

Binding to a B2 bradykinin receptor.


syntaxin-1 binding

Binding to a syntaxin-1 SNAP receptor.


antisigma factor binding

Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator.


kappa-type opioid receptor binding

Binding to a kappa-type opioid receptor.


alpha-2A adrenergic receptor binding

Binding to an alpha-2A adrenergic receptor.


KDEL sequence binding

Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.


type 1 neuropeptide Y receptor binding

Binding to a type 1 neuropeptide Y receptor.


peroxisome targeting sequence binding

Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome.


H3K9me3 modified histone binding

Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation.


D2 dopamine receptor binding

Binding to a D2 dopamine receptor.


BH3 domain binding

Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death.


interleukin-16 binding

Binding to interleukin-16.


type 1A melatonin receptor binding

Binding to a type 1A melatonin receptor.


SET domain binding

Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation.


dynactin binding

Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity.


high molecular weight kininogen binding

Binding to a kininogen of high molecular mass.


TIMP family protein binding

Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family.


neuromedin B receptor binding

Binding to a neuromedin B receptor.


transcription coactivator binding

Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.


hemoglobin alpha binding

Binding to a hemoglobin alpha chain.


LRR domain binding

Binding to a LRR domain (leucine rich repeats) of a protein.


TPR domain binding

Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices.


type 1 galanin receptor binding

Binding to a type 1 galanin receptor.


cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication

Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells.