anterior midgut development

The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure.


regulation of megakaryocyte differentiation

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.


aminodeoxyfutalosine synthase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: 3-[(1-carboxylatovinyl)oxy]benzoate(2-) + S-adenosyl-L-methionine + H2O <=> aminodeoxyfutalosinate + L-methionine + hydrogencarbonate + H+.


Kdo transferase activity

Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP.


protein localization to cell tip

A process in which a protein is transported to, or maintained in, a location at the cell tip.


D-arabinose 1-dehydrogenase (NADP+) activity

Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH.


suppression by virus of host type II interferon-mediated signaling pathway

Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type II interferon-mediated signaling in the host organism. Type II interferon is also known as interferon-gamma.


positive regulation of skeletal muscle hypertrophy

Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy.


transcription coregulator activity

A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.


negative regulation of NK T cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation.


anther wall tapetum cell fate specification

The process in which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


nitrogen cycle metabolic process

A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.


intercellular bridge organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another.


mesenchymal-endodermal cell signaling involved in lung induction

Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell in the foregut and contributes to the formation of the lung bud.


selenocysteine lyase activity

Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor.


cellular response to Gentian violet

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus.


myeloid dendritic cell activation

The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


regulation of mononuclear cell migration

Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.


negative regulation of trichoblast fate specification

Any process that suppresses trichoblast fate specification.


Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide.


bacitracin A catabolic process

The chemical reactions and pathways resulting in the breakdown of bacitracin A.


polyamine transmembrane transporter activity

Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other.


negative regulation of vein smooth muscle contraction

Any process that decreases the frequency, rate or extent of vein smooth muscle contraction.


nitrate transmembrane transporter activity

Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other.


alkylthioltransferase activity

Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor).


3-propylmalate synthase activity

Catalysis of the reaction: glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H+.


L-xylulose reductase (NADP+) activity

Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH.


negative regulation of cholesterol metabolic process

Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


regulation of pectin catabolic process

Any process that modulates the frequency, rate or extent of pectin catabolic process.


protein localization to adherens junction

Any process in which a protein is transported to, and/or maintained at the adherens junction.


response to bacteriocin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation.


triethanolamine lyase activity

Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde.


modulation of zoospore encystment on host

Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction.


neuromast primordium migration

The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop.


histone H3S10 kinase activity

Catalysis of the reaction: histone H3-serine (position 10) + ATP = histone H3-phosphoserine (position 10) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 10 of histone H3.


regulation of amyloid-beta clearance

Any process that modulates the frequency, rate or extent of amyloid-beta clearance.


regulation of dendritic cell differentiation

Any process that modulates the frequency, rate or extent of dendritic cell differentiation.


negative regulation of regulation of vascular associated smooth muscle cell membrane depolarization

Any process that stops, prevents or reduces the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization.


central B cell deletion

The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection.


regulation of epinephrine secretion

Any process that modulates the frequency, rate or extent of the regulated release of epinephrine.


cresol catabolic process

The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote.


cell wall disassembly

A process that results in the breakdown of the cell wall.


Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH.


tubuloglomerular feedback

The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus.


intracellularly ATP-gated chloride channel activity

Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.


positive regulation of receptor-mediated virion attachment to host cell

Any process that activates or increases the frequency, rate or extent of receptor-mediated virion attachment to host cell.


3-hydroxypropionate dehydrogenase (NADP+) activity

Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH.


membranous septum morphogenesis

The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.


cyanoalanine nitrilase activity

Catalysis of the reaction: 3-cyano-L-alanine + 2 H2O + H+ = L-aspartate + NH4.


gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity

Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 <=> gibberellin A24 + succinate + carbon dioxide + H2O.


positive regulation of heptasaccharide transport

Any process that activates or increases the frequency, rate or extent of heptasaccharide transport.


regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


surface biofilm formation

A process in which planktonically growing microorganisms grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.


positive regulation of pyroptosis

Any process that increases the frequency, rate or extent of pyroptosis.


lung epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.


Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage.


uroporphyrinogen-III synthase activity

Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III.


canonical Wnt signaling pathway involved in ureteric bud branching

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.


Catalysis of the reaction: beta-chaconine + UDP-L-rhamnose = H+ + alpha-chaconine + UDP.


pyridoxamine phosphate oxidase activity

Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to  pyridoxal 5'-phosphate + hydrogen peroxide.


suppression by symbiont of host immune response

Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction.


leukemia inhibitory factor signaling pathway

The series of molecular signals initiated by the binding of a leukemia inhibitory factor to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


regulation of malate dehydrogenase (decarboxylating) (NADP+) activity

Any process that modulates the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity.


NAD(P)H dehydrogenase (quinone) activity

Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone.


response to proline

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus.


superoxide reductase activity

Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin.


regulation of post-embryonic root development

Any process that modulates the frequency, rate or extent of post-embryonic root development.


Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring.


phosphorelay response regulator activity

Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.


flavin prenyltransferase activity

Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate.


anaerobic L-alanine catabolic process

The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP.


trachea development

The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.


histamine binding

Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.


neural tube formation

The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.


ATP biosynthetic process

The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.


negative regulation of SREBP signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway.


tRNA C5-cytosine methylation

The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine.


peripheral nervous system neuron axonogenesis

Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells.


menaquinone catabolic process

The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.


detection of UV

The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.


dTDP-L-rhamnose synthetase activity

Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+.


anesthesia-resistant memory

The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.


collecting duct development

The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder.


head kidney structural organization

The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney.


cytidylate kinase activity

Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.


Malpighian tubule stellate cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium.


secondary active monocarboxylate transmembrane transporter activity

Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism.


ectodermal placode development

The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.


transcription-coupled nucleotide-excision repair, DNA damage recognition

The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway.


Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol.


lymphocyte activation

A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.


Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate.


positive regulation of ribosome biogenesis

Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control.


myoblast maturation involved in muscle regeneration

A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


dicarboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.


histone H3-K9 dimethylation

The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone.


negative regulation of cell morphogenesis

Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.


protein localization to T cell secretory granule

A process in which a protein is transported to, or maintained in, a location within a secretory granule in a T cell.


positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.


URM1 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond.


jump response

The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.


interleukin-16 receptor activity

Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


regulation of systemic arterial blood pressure by hormone

The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.


trophectodermal cell fate commitment

The cell fate commitment of precursor cells that will become trophectoderm cells.


negative regulation of digestive system process

Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.


Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances.


endocrocin biosynthetic process

The chemical reactions and pathways resulting in the formation of endocrocin.


autophagosome membrane disassembly

The controlled breakdown of the membranes of autophagosomes.


acidic amino acid transmembrane transporter activity

Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3.


regulation of prostaglandin catabolic process

Any process that modulates the frequency, rate or extent of prostaglandin catabolic process.


regulation of metanephric glomerular mesangial cell proliferation

Any process that modulates the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.


positive regulation of anterograde axonal transport of mitochondrion

Any process that activates or increasesthe frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse.


positive regulation of Kit signaling pathway

Any process that activates or increases the frequency, rate or extent of Kit signaling pathway.


xanthine dehydrogenase activity

Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.


phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity

Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein.


epithelial cell-cell adhesion involved in epithelium migration

The attachment of an epithelial cell to another epithelial cell via adhesion molecules that contributes to epithelium migration.


beta-1,4-mannosyltransferase activity

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage.


positive regulation of complement activation, lectin pathway

Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway.


[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S.


mycinamicin VI 2''-O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI <=> S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+.


Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site.


macromolecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


phosphomethylpyrimidine kinase activity

Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.


adenohypophysis morphogenesis

The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.


S-ribosylhomocysteine lyase activity

Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine.


cuticle pattern formation

The regionalization process that gives rise to the patterns of cell differentiation in the cuticle.


cellular response to methamphetamine hydrochloride

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus.


response to endothelin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3).


glyoxylate dehydrogenase (acylating) activity

Catalysis of the reaction: CoA + glyoxylate + NADP+ = H+ + NADPH + oxalyl-CoA.


response to epinephrine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.


proximal/distal pattern formation involved in pronephric nephron development

The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros.


regulation of toll-like receptor 15 signaling pathway

Any process that modulates the frequency, rate or extent of toll-like receptor 15 signaling pathway.


Cvt vesicle assembly

A vesicle organization process that takes place as part of the Cvt pathway, and results in the formation of a double membrane-bounded cytosolic structure that sequesters precursor aminopeptidase I (prAPI).


tissue migration

The process in which the population of cells that make up a tissue undergo directed movement.


regulation of interleukin-2-mediated signaling pathway

Any process that modulates the frequency, rate or extent of interleukin-2-mediated signaling pathway.


Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-.


starch, H2O dikinase activity

Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin.


viral entry via permeabilization of host membrane

The entry of a virus into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration capsid protein. Results in release of the virus contents into the host cell cytoplasm.


negative regulation of growth rate

Any process that reduces the rate of growth of all or part of an organism.


alpha-zingiberene synthase activity

Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> zingiberene + diphosphoric acid.


cytochrome complex assembly

The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.


negative regulation of tendon cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of tendon cell differentiation.


positive regulation of ATF6-mediated unfolded protein response

Any process that activates or increases the frequency, rate or extent of the ATF6-mediated unfolded protein response.


sulfate reduction

The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate.


cholesterol catabolic process

The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


protein-containing complex disassembly

The disaggregation of a protein-containing macromolecular complex into its constituent components.


envenomation resulting in modulation of apoptotic process in another organism

A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of apoptosis in the bitten organism.


vesicle fusion with vesicle

Fusion of the membrane of a transport vesicle with a target membrane on another vesicle.


isoprenoid binding

Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


neurotrophin TRK receptor signaling pathway

The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.


Catalysis of the reaction: 2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate.


cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules.


cGMP catabolic process

The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate.


cyclic nucleotide-dependent protein kinase activity

cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


response to copper ion starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of copper ion.


NK T cell lineage commitment

The process in which a pro-T cell becomes committed to becoming an NK T cell.


suspensor development

The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm.


monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity

Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O.


regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.


ureidoglycolate lyase activity

Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea.


endodermal cell fate determination

The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.


Catalysis of the reaction: H+ + 3,4-dihydroxyphenylpyruvate + NADPH <=> (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP.


regulation of vesicle transport along microtubule

Any process that modulates the frequency, rate or extent of vesicle transport along microtubule.


late distal convoluted tubule development

The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive.


negative regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process.


regulation of long-chain fatty acid import into cell

Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell.


demethylase activity

Catalysis of the removal of a methyl group from a substrate.


negative regulation of pollen tube guidance

Any process that decreases the rate, frequency or extent of pollen tube guidance towards ovules. This is one mechanism to prevent polytuby, the simultaneous penetration of ovules by multiple pollen tubes.


oxidation-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein.


terephthalate decarboxylase activity

Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-.


XTP binding

Binding to XTP.


gamma-tubulin complex assembly

The aggregation, arrangement and bonding together of a set of components to form a gamma-tubulin complex.


fibroblast migration

Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.


regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress.


melatonin receptor activity

Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.


positive regulation of tumor necrosis factor-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway.


hemoglobin biosynthetic process

The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


actin polymerization or depolymerization

Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.


positive regulation of transepithelial migration of symbiont in host

Any process that activates or increases the frequency, rate or extent of transepithelial migration of symbiont in host.


adenosylcobinamide kinase activity

Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP).


Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS.


glutamine family amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.


methanophenazine biosynthetic process

The chemical reactions and pathways resulting in the formation of methanophenazine.


phenylserine aldolase activity

Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine.


protein localization to mitotic spindle pole body

A process in which a protein is transported to, or maintained in, a location within a mitotic spindle pole body.


peripheral B cell negative selection

Any process leading to negative selection of B cells in the periphery.


mast cell proliferation

The expansion of a mast cell population by cell division.


p-cymene catabolic process

The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants.


glucocorticoid biosynthetic process

The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.


epithelial cell-cell adhesion

The attachment of an epithelial cell to another epithelial cell via adhesion molecules.


non-recombinational interstrand cross-link repair

Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination.


tartrate dehydrogenase activity

Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+.


toluene-4-sulfonate metabolic process

The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water.


hopanoid metabolic process

The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus.


response to host defenses

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


2,2-dialkylglycine decarboxylase (pyruvate) activity

Catalysis of the reaction: 2,2-dialkylglycine + H+ + pyruvate = L-alanine + CO2 + dialkyl ketone.


establishment of protein localization

The directed movement of a protein to a specific location.


iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide

The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide.


pronephric glomerulus development

The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.


regulation of (1->3)-beta-D-glucan metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans.


ncRNA deadenylation

Shortening of the poly(A) tail of a nuclear-transcribed ncRNA.


meristem structural organization

Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue.


methylguanidinase activity

Catalysis of the reaction: H2O + methylguanidine = methylammonium + urea.


RNA polymerase I activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


regulation of actin filament-based process

Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.


sensory perception of mechanical stimulus

The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


cellular response to vitamin B3

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus.


The chemical reactions and pathways involving (-)-exo-alpha-bergamotene.


phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline

The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine.


malate metabolic process

The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.


regulation of positive chemotaxis to cAMP by chlorinated alkylphenone

Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions.


Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.


cerebral cortex regionalization

The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops.


ectodermal digestive tract development

The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm.


embryonic skeletal limb joint morphogenesis

The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.


Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.


Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate.


postsynaptic neurotransmitter receptor diffusion trapping

The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization.


carbon fixation by acetyl-CoA pathway

A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2).


brain segmentation

Division of the brain into a series of semi-repetitive parts or segments.


receptor localization to synapse

Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


T cell extravasation

The migration of a T cell from the blood vessels into the surrounding tissue.


globoside metabolic process

The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes.


cardiac muscle cell myoblast differentiation

The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.


mitochondrial membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.


Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate.


metanephric mesenchymal cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state.


strigolactone biosynthetic process

The chemical reactions and pathways resulting in the formation of strigolactone.


extracellular phenylacetaldehyde-gated monoatomic ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts.


aerenchyma formation

The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts.


bulbus arteriosus formation

The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart.


tetrahydrothiophene 1-oxide reductase activity

Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor.


tetrahydrobiopterin binding

Binding to a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions.


immunoglobulin production in mucosal tissue

The synthesis and release of immunoglobulin in the mucosal tissue.


purine deoxyribonucleoside salvage

Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis.


Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde + H+.


cell wall (1->3)-alpha-glucan biosynthetic process

The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-glucosidic bonds, found in the walls of cells.


zymogen activation

The proteolytic processing of an inactive enzyme to an active form.


negative regulation of macrophage derived foam cell differentiation

Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


peptide cross-linking via sn-(2S,6R)-lanthionine

The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione).


mitotic checkpoint complex assembly

The aggregation, arrangement and bonding together of a set of components to form a mitotic checkpoint complex.


renal protein absorption

A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).


pallium glioblast division

The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells.


response to 5-fluoro-2'-deoxyuridine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.


trigeminal ganglion morphogenesis

The process in which the anatomical structure of a trigeminal ganglion is generated and organized.


regulation of systemic arterial blood pressure by epinephrine

The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine.


macrophage cytokine production

The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


mitochondria-associated ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions.


negative regulation of cardiac muscle cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.


intracellular copper ion homeostasis

A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell.


glycosylation

The covalent attachment and further modification of carbohydrate residues to a substrate molecule.


circadian regulation of heart rate by the suprachiasmatic nucleus

The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours.


auxin receptor activity

Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone).


regulation of tube diameter, open tracheal system

Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size.


positive regulation of the force of heart contraction by epinephrine-norepinephrine

Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.


protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine

The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine.


response to TNF agonist

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus.


B cell apoptotic process

Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.


cellular response to indole-3-methanol

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus.


tricarboxylate secondary active transmembrane transporter activity

Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.


inositol diphosphate pentakisphosphate diphosphatase activity

Catalysis of the reaction: diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate.


U7 snRNA binding

Binding to a U7 small nuclear RNA (U7 snRNA).


estrous cycle

A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.


intermediate mesoderm structural organization

The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure.


(S)-2-methylmalate dehydratase activity

Catalysis of the reaction: S-citramalate = H2O + mesaconate.


regulation of motor neuron migration

Any process that modulates the frequency, rate or extent of motor neuron migration.


regulation of cardiac muscle cell contraction

Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.


ABC-type cadmium transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole).


negative regulation of glucose import

Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.


ADP-dependent short-chain-acyl-CoA hydrolase activity

Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA.


nucleotide-excision repair involved in interstrand cross-link repair

Any nucleotide-excision repair that is involved in interstrand cross-link repair.


cellular response to histamine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.


flavone apiosyltransferase activity

Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone.


regulation of cytokinesis

Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.


regulation of ventricular cardiac muscle cell membrane depolarization

Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte.


presynapse to nucleus signaling pathway

The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).


self-resistance to endogenously produced metabolite

A process that reduces or removes the toxicity of an endogenously produced substance. Mechanisms of resistance to endogenously produced compounds include modification the compound, export, sequestration, or mutations in the target enzyme.


N-acylglucosamine 2-epimerase activity

Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine.


neural tube closure

The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.


protein localization to trailing edge

A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement.


purine ribonucleotide binding

Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.


eurydendroid cell differentiation

The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts.


anterior lateral line development

The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear.


vacuolar protein processing

Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.


lymphocyte migration into lymph node

The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen.


negative regulation of glomerular filtration by angiotensin

The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.


regulation of positive thymic T cell selection

Any process that modulates the frequency, rate or extent of positive thymic T cell selection.


cellular response to decreased oxygen levels

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.


L-arabinose biosynthetic process

The chemical reactions and pathways resulting in the formation of L-arabinose, arabino-pentose.


ubiquitin-like protein transferase activity

Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.


Leydig cell proliferation

The multiplication or reproduction of Leydig cells, resulting in the expansion of a cell population. Leydig cells are interstitial cells located adjacent to the seminiferous tubules in the testis which produce testosterone.


The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine.


regulation of gastric mucosal blood circulation

Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation.


histone H4K16 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4.


regulation of establishment of competence for transformation

Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome.


GGU codon-amino acid adaptor activity

A triplet codon-amino acid adaptor activity that recognizes a GGU codon.


cardiac right ventricle morphogenesis

The process in which the right cardiac ventricle is generated and organized.


isopullulanase activity

Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose).


phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity

Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol.


central B cell tolerance induction

Tolerance induction of B cells in the bone marrow.


CD4-positive gamma-delta intraepithelial T cell differentiation

The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.


The chemical reactions and pathways resulting in the breakdown of N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group.


dimethyl ether metabolic process

The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications.


regulation of systemic arterial blood pressure mediated by a chemical signal

The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine.


Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin.


positive regulation of peptidoglycan recognition protein signaling pathway

Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway.


glucosylglycerol transmembrane transporter activity

Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol.


modulation of blood pressure in another organism

A process by which one organism modulates the force with which blood travels through the circulatory system of another organism.


positive regulation of CD8-positive, alpha-beta T cell activation

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.


extracellular exosome biogenesis

The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.


peptidyl-proline 3-dioxygenase activity

Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2.


spore wall biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore.


myelination

The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.


hindbrain development

The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).


compartment boundary maintenance

A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier.


beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.


Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate.


GGC codon-amino acid adaptor activity

A triplet codon-amino acid adaptor activity that recognizes a GGC codon.


histone H4-K12 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone.


codeine metabolic process

The chemical reactions and pathways involving codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties.


regulation of retinal rod cell fate commitment

Any process that modulates the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye.


Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD.


sucrose alpha-glucosidase activity

Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose.


regulation of steroid hormone secretion

Any process that modulates the frequency, rate or extent of steroid hormone secretion.


isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process

The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway that contributes to terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates.


3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.


acetate transmembrane transporter activity

Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid.


response to cyanide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus.


(S)-corytuberine synthase activity

Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O.


NADPH-dependent dihydrocurcumin reductase activity

Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+.


regulation of macrophage tolerance induction

Any process that modulates the frequency, rate, or extent of macrophage tolerance induction.


mast cell homeostasis

The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


heparan sulfate N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate.


tetraterpenoid catabolic process

The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units.


vitexin 2''-O-rhamnoside 7-O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside.


mesonephric mesenchyme development

The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros.


fatty acid derivative catabolic process

The chemical reactions and pathways resulting in the breakdown of fatty acid derivative.


sodium-dependent self proteolysis

The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.


negative regulation of Wnt signaling pathway, calcium modulating pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).


protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity

Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in).


guanosine deaminase activity

Catalysis of the reaction: guanosine + H2O = xanthosine + NH3.


regulation of blood pressure

Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.


thigmotropism

The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it.


Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.


auxin conjugate metabolic process

The chemical reactions and pathways involving auxin conjugates, a bound form of auxin.


benzene-containing compound metabolic process

The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives.


trihydroxytoluene dioxygenase activity

Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate.


S-methylmethionine biosynthetic process

The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle.


versiconal reductase activity

Catalysis of the reaction: versiconol + NADP <=> versiconal hemiacetal + NADPH + H+.


D-xylose fermentation

The anaerobic enzymatic conversion of D-xylose to ethanol, yielding energy in the form of ATP.


Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.


regulation of endoplasmic reticulum unfolded protein response

Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response.


negative regulation of toll-like receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.


iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide

The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide.


helper T cell diapedesis

The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.


pollen wall assembly

The formation of reticulate pollen wall pattern consisting of two layers, exine and intine.


phytol kinase activity

Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+.


myeloid leukocyte migration

The movement of a myeloid leukocyte within or between different tissues and organs of the body.


amide metabolic process

The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.


protein-disulfide reductase (glutathione) activity

Catalysis of the reaction: 2 glutathione + protein-disulfide = glutathione disulfide+ protein-dithiol.


cellular response to heparin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.


apiose metabolic process

The chemical reactions and pathways involving apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose.


cyclization of glutamine involved in intein-mediated protein splicing

The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing.


disruption of host tight cell-cell junction

The process by which a symbiont effects a change in the structure or function of tight cell-cell junctions between cells of the host. Tight cell-cell junctions, a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.


DNA double-strand break processing involved in repair via single-strand annealing

The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing.


response to water-immersion restraint stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile.


protein O-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.


Catalysis of the reaction: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NADP <=> (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADPH + H+.


Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose.


GABAergic neuron differentiation

The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron.


cobinamide kinase activity

Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate.


regulation of muscle hypertrophy

Any process that modulates the frequency, rate or extent of muscle hypertrophy.


ATPase-coupled L-glutamine transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in).


3'-5' DNA/RNA helicase activity

Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis.


Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+.


cardioblast cell fate commitment

The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


histone H3R8 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3.


benzyladenine UDP glycosyltransferase activity

Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP.


positive regulation of cardiac muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.


antigen processing and presentation of exogenous peptide antigen via MHC class II

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.


histone H4K12 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 12) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 12). This reaction is the addition of a methyl group to the lysine residue at position 12 of the histone H4 protein.


heme a metabolic process

The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3.


steryl-beta-glucosidase activity

Catalysis of the reaction: cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol.


regulation of actin filament severing

Any process that modulates the frequency, rate or extent of actin filament severing.


histamine-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts.


hippocampus development

The progression of the hippocampus over time from its initial formation until its mature state.


embryonic axis specification

The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.


sperm DNA decondensation

Unwinding of the condensed nuclear chromatin of an inactive male pronucleus after fertilization.


positive regulation of heart rate by epinephrine

The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.


Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate.


fluoren-9-ol dehydrogenase activity

Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+.


regulation of twitch skeletal muscle contraction

Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction.


RNA polymerase V activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


posterior lateral line neuromast support cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells.


response to methionine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus.


negative regulation of astrocyte chemotaxis

Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis.


regulation of vasoconstriction by circulating norepinephrine

Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.


T cell secretory granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.


embryonic digestive tract morphogenesis

The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.


positive regulation of cartilage condensation

Any process that activates or increases the frequency, rate or extent of cartilage condensation.


lateral ventricle development

The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.


alpha-linked polysaccharide catabolism to maltotriose

The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltotriose.


phenanthrol sulfotransferase activity

Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate.


phosphate ion homeostasis

Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell.


intracellular monoatomic cation homeostasis

A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom.


protein N-linked glycosylation via tryptophan

The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue.


serine-type D-Ala-D-Ala carboxypeptidase activity

Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine.


oocyte microtubule cytoskeleton polarization

Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster.


molybdopterin synthase activity

Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.


protein disulfide isomerase activity

Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.


positive regulation of androstenedione secretion

Any process that activates or increases the frequency, rate or extent of androstenedione secretion.


zymosterol biosynthetic process

The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol).


regulation of meristem development

Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure.


protein K48-linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


positive regulation of sprouting angiogenesis

Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.


negative regulation of heat generation

Any process that stops, prevents, or reduces the rate or extent of heat generation.


regulation of single-species biofilm formation

Any process that modulates the frequency, rate or extent of single-species biofilm formation.


negative regulation of hemopoiesis

Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.


establishment or maintenance of epithelial cell apical/basal polarity

Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.


interferon-alpha production

The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


leading edge cell fate determination

The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed.


Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U.


protein-heme linkage via 3'-L-histidine

The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine).


Malpighian tubule bud morphogenesis

The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position.


endo-alpha-(2,8)-sialidase activity

Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids.


retinoic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A.


DNA excision

The removal of a section of DNA from a larger DNA molecule by the making of dual incisions that flank the section to be excised.


regulation of multicellular organismal development

Any process that modulates the frequency, rate or extent of multicellular organismal development.


sinoatrial node cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node.


mitochondrial respiratory chain complex assembly

The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.


sphingomyelin metabolic process

The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.


kappa-carrageenase activity

Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans.


The chemical reactions and pathways involving 5,6,7,8-tetrahydromethanopterin.


lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate

The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps.


epinephrine binding

Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.


lactase activity

Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.


secondary heart field specification

The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).


activation of prostate induction by androgen receptor signaling pathway

The series of molecular signals initiated by androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland.


prostaglandin transmembrane transporter activity

Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.


positive regulation of inhibin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell.


protein modification by small protein conjugation or removal

A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.


endoplasmic reticulum cisternal network maintenance

The organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section.


mycodextranase activity

Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds.


GSI anchor metabolic process

The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane.


spermine metabolic process

The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.


CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.


RNA translocase activity

Generating a movement along a single- or double-stranded RNA molecule, driven by ATP hydrolysis.


mammary stem cell proliferation

The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ.


ribosome disassembly

The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.


positive regulation of toll-like receptor 9 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway.


cellular response to monoamine stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.


ciliary pro-basal body maturation

A process that is carried out at the cellular level which results in the conversion of an immature and partially assembled ciliary pro-basal body into a mature basal body that is capable of nucleating a cilium.


negative regulation of hepatocyte apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process.


detection of stimulus involved in sensory perception

The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal.


distal tubule development

The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule.


negative regulation of starch metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of starch metabolic process.


granuloma formation

The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.


regulation of neuromuscular synaptic transmission

Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission.


muscle cell fate specification

The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


simple leaf morphogenesis

The leaf morphogenesis process which results in the shaping of a simple leaf. A simple leaf is a leaf in which the lamina is undivided.


retina development in camera-type eye

The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.


regulation of flavonol biosynthetic process

Any process that modulates the frequency, rate or extent of flavonol biosynthetic process.


cyclization of asparagine involved in intein-mediated protein splicing

The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing.


Kupffer's vesicle development

The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.


iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide

The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide.


negative regulation of synaptic transmission, glycinergic

Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine.


O antigen metabolic process

The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.


chorismate synthase activity

Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.


negative regulation of exo-alpha-sialidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of exo-alpha-sialidase activity.


vasculogenesis

The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.


HRI-mediated signaling

A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock.


sporangiospore formation

The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm.


4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity

Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H+.


Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine in mucin-type glycoproteins.