negative regulation of metallopeptidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity.


negative regulation of amyloid precursor protein biosynthetic process

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.


negative regulation of histone H3-K9 trimethylation

Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 trimethylation.


positive regulation of protein catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


regulation of protein catabolic process in the vacuole

Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole.


positive regulation of anaphase-promoting complex-dependent catabolic process

Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


negative regulation of exonucleolytic catabolism of deadenylated mRNA

Any process that stops, prevents, or reduces the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay.


positive regulation of Lys63-specific deubiquitinase activity

Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity.


negative regulation by symbiont of host translation

The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism.


regulation of blood coagulation, extrinsic pathway

Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway.


positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.


regulation of protein autoubiquitination

Any process that modulates the frequency, rate or extent of protein autoubiquitination.


positive regulation of CD80 production

Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process.


negative regulation of translational initiation in response to stress

Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.


regulation of translational termination

Any process that modulates the frequency, rate or extent of translational termination.


negative regulation of myosin light chain kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity.


positive regulation of histone H4-K20 methylation

Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4.


positive regulation of ceramide biosynthetic process

Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process.


negative regulation of glycoprotein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process.


positive regulation of mitochondrial translation

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


regulation of histone H2B ubiquitination

Any process that modulates the frequency, rate or extent of histone H2B ubiquitination.


negative regulation of FasL production

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.


negative regulation of glutathione biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of glutathione biosynthetic process.


activation of protein kinase A activity

Any process that initiates the activity of the inactive enzyme protein kinase A.


positive regulation of lymphotoxin A production

Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production.


negative regulation of histone H3-K27 methylation

Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.


regulation of phosphoprotein phosphatase activity

Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.


negative regulation of low-density lipoprotein particle receptor catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors.


negative regulation of proteolysis involved in protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process.


regulation of histone deacetylase activity

Any process that modulates the frequency, rate or extent of histone deacetylase activity.


regulation of protein deacetylation

Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


negative regulation of protein autophosphorylation

Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.


positive regulation of translational initiation in response to osmotic stress

Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


regulation of translation, ncRNA-mediated

Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein.


positive regulation of membrane protein ectodomain proteolysis

Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.


regulation of mitochondrial translational elongation

Any process that modulates the frequency, rate or extent of mitochondrial translational elongation.


negative regulation of protein acetylation

Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation.


positive regulation of ubiquitin protein ligase activity

Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity.


regulation of translational initiation in response to stress

Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress.


positive regulation of urea catabolic process

Any process that activates or increases the frequency, rate or extent of urea catabolic process.


regulation of metalloendopeptidase activity

Any process that modulates the frequency, rate or extent of metalloendopeptidase activity.


regulation of chaperone-mediated autophagy

Any process that modulates the frequency, rate or extent of chaperone-mediated autophagy.


negative regulation of protein linear polyubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein linear polyubiquitination.


regulation of protein tyrosine kinase activity

Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity.


negative regulation of translational initiation

Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.


negative regulation of Toll receptor ligand protein activation cascade

Any process that stops, prevents or reduces the frequency, rate or extent of Toll receptor ligand protein activation cascade.


positive regulation of protein modification by small protein conjugation or removal

Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal.


negative regulation of peptide hormone processing

Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone.


regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.


regulation of cytoplasmic translational initiation in response to stress

Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


regulation of epidermal growth factor-activated receptor activity

Any process that modulates the frequency, rate or extent of EGF-activated receptor activity.


positive regulation of peptidase activity

Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.


positive regulation of N-terminal peptidyl-methionine acetylation

Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-methionine acetylation.


negative regulation of protein maturation

Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation.


regulation of post-translational protein modification

Any process that modulates the frequency, rate or extent of post-translational protein modification.


positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.


regulation of peptidyl-serine dephosphorylation

Any process that modulates the frequency, rate or extent of peptidyl-serine dephosphorylation.


regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Any process that modualtes the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


regulation of myosin light chain kinase activity

Any process that modulates the frequency, rate or extent of myosin light chain kinase activity.


positive regulation of cAMP-dependent protein kinase activity

Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.


negative regulation of protein catabolic process in the vacuole

Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole.


negative regulation of cytoplasmic translational initiation

Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation.


positive regulation of amyloid precursor protein catabolic process

Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process.


regulation of histone deubiquitination

Any process that modulates the frequency, rate or extent of histone deubiquitination.


positive regulation of formation of translation preinitiation complex

Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex.


positive regulation of N-terminal peptidyl-serine acetylation

Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-serine acetylation.


negative regulation of cap-dependent translational initiation

Any process that stops, prevents or reduces the frequency, rate or extent of cap-dependent translational initiation.


polyuridylation-dependent mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA.


negative regulation of ceramide biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.


negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.


negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.


negative regulation of tubulin deacetylase activity

Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylase activity.


positive regulation of ubiquitin-protein transferase activity

Any process that activates, maintains or increases the rate of ubiquitin transferase activity.


regulation of antifungal peptide biosynthetic process

Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis.


positive regulation of peptidyl-cysteine S-nitrosylation

Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.


positive regulation of SUMO transferase activity

Any process that activates or increases the frequency, rate or extent of SUMO transferase activity.


regulation of protein kinase C activity

Any process that modulates the frequency, rate or extent of protein kinase C activity.


regulation of metallopeptidase activity

Any process that modulates the frequency, rate or extent of metallopeptidase activity.


regulation of protein geranylgeranylation

Any process that modulates the frequency, rate or extent of protein geranylgeranylation.


negative regulation of protein serine/threonine kinase activity

Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.


viral translational readthrough

The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons.


regulation of cysteine-type endopeptidase activity

Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity.


positive regulation of histone methylation

Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones.


regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.


regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress.


negative regulation of protein histidine kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity.


negative regulation of histone H3-K4 methylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.


negative regulation of translational initiation in response to starvation

Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment.


positive regulation of exonucleolytic catabolism of deadenylated mRNA

Any process that activates or increases the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay.


positive regulation of amide metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides.


regulation of siderophore biosynthetic process

Any process that modulates the frequency, rate or extent of siderophore biosynthetic process.


regulation of protein ubiquitination

Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.


positive regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that activates or increases the frequency, rate or extent of CDK activity.


negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


regulation of protein catabolic process at postsynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.


regulation of protein glutathionylation

Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.


positive regulation of myosin-light-chain-phosphatase activity

Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity.


negative regulation of oskar mRNA translation

Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein.


positive regulation of histone H4 acetylation

Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group.


positive regulation of glucosylceramide biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


negative regulation of SUMO transferase activity

Any process that stops, prevents or reduces the frequency, rate or extent of SUMO ligase activity.


regulation of histone H3-K27 trimethylation

Any process that modulates the frequency, rate or extent of histone H3-K27 trimethylation.


regulation of protein deneddylation

Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein.


positive regulation of cytoplasmic translational elongation

Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation.


regulation of endopeptidase activity

Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


positive regulation of low-density lipoprotein particle receptor catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors.


negative regulation of protein processing involved in protein targeting to mitochondrion

Any process that stops, prevents or reduces the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion.


positive regulation of protein autophosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.


negative regulation of protein kinase activity by regulation of protein phosphorylation

The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.


negative regulation of histone H3-K9 acetylation

Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation.


negative regulation of protein activation cascade

Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade.


regulation of histone ubiquitination

Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein.


negative regulation of cysteine-type endopeptidase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity.


regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.


negative regulation of protein oxidation

Any process that stops, prevents or reduces the frequency, rate or extent of protein oxidation.


positive regulation of oskar mRNA translation

Any process that activates or increases the frequency, rate or extent of oskar mRNA translation.


pyrrolysine incorporation

The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases.


positive regulation of hemoglobin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


negative regulation of histone deacetylase activity

Any process that stops, prevents or reduces the frequency, rate or extent of histone deacetylase activity.


regulation of histone acetylation

Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein.


positive regulation of peptidyl-serine dephosphorylation

Any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation.


positive regulation of pentose-phosphate shunt

Any process that activates or increases the frequency, rate or extent of pentose-phosphate shunt.


regulation of activation of Janus kinase activity

Any process that modulates the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.


positive regulation of blood coagulation, extrinsic pathway

Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway.


positive regulation of glycoprotein biosynthetic process

Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.


regulation of actin phosphorylation

Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.


eIF2alpha dephosphorylation in response to endoplasmic reticulum stress

The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.


negative regulation of translation in response to oxidative stress

Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


positive regulation of protein tyrosine kinase activity

Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.


negative regulation of anaphase-promoting complex-dependent catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


positive regulation of protein acetylation

Any process that activates or increases the frequency, rate or extent of protein acetylation.


positive regulation of protein serine/threonine phosphatase activity

Any process that activates or increases the frequency, rate or extent of protein serine/threonine phosphatase activity.


negative regulation of ER-associated ubiquitin-dependent protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process.


negative regulation of translational initiation by iron

Any process involving iron that stops, prevents or reduces the rate of translational initiation.


3'-UTR-mediated mRNA destabilization

An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.


negative regulation of amide catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.


positive regulation of granulocyte macrophage colony-stimulating factor production

Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


positive regulation of peptidyl-serine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.


negative regulation of siderophore biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of siderophore biosynthetic process.


negative regulation of lipoprotein metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.


positive regulation of peptidyl-lysine acetylation

Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation.


negative regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.


negative regulation of protein sumoylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.


positive regulation of N-terminal peptidyl-lysine acetylation

Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation.


negative regulation of mitochondrial translational initiation

Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


negative regulation of histone deubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of histone deubiquitination.


regulation of translation by machinery localization

Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.


regulation of amyloid precursor protein catabolic process

Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.


positive regulation of amyloid precursor protein biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.


positive regulation of protein tyrosine phosphatase activity

Any process that activates or increases the frequency, rate or extent of protein tyrosine phosphatase activity.


regulation of cytoplasmic translation in response to stress

Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


regulation of aspartic-type peptidase activity

Any process that modulates the frequency, rate or extent of aspartic-type peptidase activity.


positive regulation of protein deubiquitination

Any process that activates or increases the frequency, rate or extent of protein deubiquitination.


regulation of histone H3-K27 methylation

Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.


positive regulation of protein maturation

Any process that activates or increases the frequency, rate or extent of protein maturation.


positive regulation of lysosomal protein catabolic process

Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.


regulation of protein serine/threonine phosphatase activity

Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.


negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation.


regulation of translation at postsynapse

Any process that regulates translation occurring at the postsynapse.


positive regulation of heparan sulfate proteoglycan biosynthetic process

Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues.


positive regulation of inhibitory G protein-coupled receptor phosphorylation

Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.


negative regulation of serine-type endopeptidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.


regulation of translation involved in anterior/posterior axis specification

Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis.


regulation of glycoprotein biosynthetic process

Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.


negative regulation of elastin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.


regulation of protein-pyridoxal-5-phosphate linkage

Any process that modulates the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


regulation of tyrosine phosphorylation of STAT protein

Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


positive regulation of protein monoubiquitination

Any process that activates or increases the frequency, rate or extent of protein monoubiquitination.


positive regulation of ERAD pathway

Any process that activates or increases the frequency, rate or extent of ERAD pathway.


negative regulation of translation in response to stress

Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress.


positive regulation of post-translational protein modification

Any process that activates or increases the frequency, rate or extent of post-translational protein modification.


positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation.


negative regulation of tubulin deacetylation

Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.


negative regulation of formation of translation preinitiation complex

Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex.


regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


positive regulation of protein polyubiquitination

Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.


regulation of protein dephosphorylation

Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein.


regulation of proteolysis involved in protein catabolic process

Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process.


negative regulation of antifungal peptide biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis.


negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process.


positive regulation of blood coagulation, common pathway

Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway.


regulation of translation in response to stress

Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.


positive regulation of protein processing

Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.


positive regulation of pseurotin A biosynthetic process

Any process that activates or increases the frequency, rate or extent of pseurotin A biosynthetic process.


negative regulation of protein polyglycylation

Any process that stops, prevents or reduces the frequency, rate or extent of protein polyglycylation.


regulation of non-membrane spanning protein tyrosine kinase activity

Any process that modulates the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.


positive regulation of mitochondrial translational elongation

Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation.


negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


regulation of peptidase activity

Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.


regulation of cytoplasmic translation

Any process that modulates the frequency, rate or extent of cytoplasmic translation.


negative regulation of protein processing

Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.


regulation of translation at presynapse

Any process that regulates translation occurring at the presynapse.


regulation of protein modification by small protein conjugation or removal

Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal.


negative regulation of protein-pyridoxal-5-phosphate linkage

Any process that stops, prevents or reduces the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


positive regulation of cysteine-type endopeptidase activity

Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.


positive regulation of translation initiation in response to endoplasmic reticulum stress

Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.


positive regulation of protein adenylylation

Any process that activates or increases the frequency, rate or extent of protein adenylylation.


circadian regulation of translation

Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours.


positive regulation of plasma kallikrein-kinin cascade

Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade.


negative regulation of N-terminal peptidyl-methionine acetylation

Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-methionine acetylation.


regulation of translation in response to oxidative stress

Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


positive regulation of protein linear polyubiquitination

Any process that activates or increases the frequency, rate or extent of protein linear polyubiquitination.


regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.


negative regulation of pseurotin A biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of pseurotin A biosynthetic process.


negative regulation of endopeptidase activity

Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


regulation of kinin cascade

Any process that modulates the frequency, rate, or extent of the kinin cascade.


regulation of protein maturation

Any process that modulates the frequency, rate or extent of protein maturation.


regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.


positive regulation of glucosylceramide catabolic process

Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process.


negative regulation of protein adenylylation

Any process that stops, prevents or reduces the frequency, rate or extent of protein adenylylation.


regulation of emericellamide biosynthetic process

Any process that modulates the frequency, rate or extent of emericellamide biosynthetic process.


negative regulation of translational initiation in response to osmotic stress

Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


regulation of protein tyrosine phosphatase activity

Any process that modulates the frequency, rate or extent of protein tyrosine phosphatase activity.


positive regulation of hepatocyte growth factor production

Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production.


negative regulation of Rho-dependent protein serine/threonine kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity.


inhibition of cysteine-type endopeptidase activity

Any process that prevents the activation of an inactive cysteine-type endopeptidase.


negative regulation of activation of Janus kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK (Janus Activated Kinase) kinase activity.


positive regulation of antifungal peptide biosynthetic process

Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis.


negative regulation of epidermal growth factor-activated receptor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.


regulation of inhibitory G protein-coupled receptor phosphorylation

Any process that modulates the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.


negative regulation of lipoprotein oxidation

Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation.


positive regulation of histone H2B ubiquitination

Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination.


regulation of selenocysteine incorporation

Any process that modulates the frequency, rate or extent of selenocysteine incorporation.


positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.


negative regulation of nuclear-transcribed mRNA poly(A) tail shortening

Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.


regulation of granulocyte macrophage colony-stimulating factor production

Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


positive regulation of antibacterial peptide biosynthetic process

Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis.


regulation of protein autophosphorylation

Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.


negative regulation of granulocyte macrophage colony-stimulating factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


positive regulation of elastin catabolic process

Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.


negative regulation of protein phosphorylation

Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.


piRNA-mediated gene silencing by mRNA destabilization

A cytoplasmic post-transcriptional gene silencing pathway in which piRNAs direct the cleavage of target mRNAs. The target mRNA, often transcribed from a transposable element, is destabilized by the activity of a PIWI class endonuclease within the piRNA-induced silencing complex. This may also be accompanied by mRNA deadenylation and decapping.


positive regulation of peptidyl-serine phosphorylation of STAT protein

Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


positive regulation of non-membrane spanning protein tyrosine kinase activity

Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.


positive regulation of metallopeptidase activity

Any process that activates or increases the frequency, rate or extent of metallopeptidase activity.


negative regulation of proteasomal protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.


positive regulation of FasL production

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.


regulation of cytoplasmic translational termination

Any process that modulates the frequency, rate or extent of cytoplasmic translational termination.


negative regulation of ferrichrome biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of ferrichrome biosynthetic process.


positive regulation of proteoglycan biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


negative regulation of ferrichrome biosynthetic process in response to iron

Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus.


regulation of JUN kinase activity

Any process that modulates the frequency, rate or extent of JUN kinase activity.


regulation of histone methylation

Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones.


negative regulation of protein tyrosine kinase activity

Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity.


positive regulation of protein serine/threonine kinase activity

Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.


negative regulation of protein metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.


positive regulation of MAP kinase activity

Any process that activates or increases the frequency, rate or extent of MAP kinase activity.


negative regulation of protein K63-linked deubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked deubiquitination.


positive regulation of histone H3-K9 methylation

Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.


regulation of cyclin-dependent protein kinase activity

Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity.


regulation of peptidyl-lysine crotonylation

Any process that modulates the frequency, rate or extent of crotonylation of a lysine residue in a protein.


negative regulation of cytoplasmic translational initiation in response to stress

Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.


modulation by symbiont of host translation

The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism.


regulation of tissue kallikrein-kinin cascade

Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade.


positive regulation of histone H3-K27 methylation

Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.


regulation of FasL production

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.


regulation of protein catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


regulation of protein catabolic process at presynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.


negative regulation of tissue kallikrein-kinin cascade

Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade.


regulation of hemoglobin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


regulation of ER-associated ubiquitin-dependent protein catabolic process

Any process that modulates the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process.


negative regulation of serine-type peptidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity.


modulation by virus of host translation

Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA.


regulation of protein polyglycylation

Any process that modulates the frequency, rate or extent of protein polyglycylation.


positive regulation of tubulin deacetylase activity

Any process that activates or increases the frequency, rate or extent of tubulin deacetylase activity.


positive regulation of protein glutathionylation

Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.


positive regulation of histone H3-K9 dimethylation

Any process that activates or increases the frequency, rate or extent of histone H3-K9 dimethylation.


positive regulation of mitochondrial translational initiation

Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


regulation of plasma kallikrein-kinin cascade

Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade.


positive regulation of proteasomal protein catabolic process

Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.


regulation of histone deacetylation

Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones.


regulation of amyloid precursor protein biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.


negative regulation of ubiquitin protein ligase activity

Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.


regulation of membrane protein ectodomain proteolysis

Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


positive regulation of protein processing in phagocytic vesicle

Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle.


negative regulation of protein ubiquitination

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.


negative regulation of histone ubiquitination

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of a ubiquitin group to a histone protein.


negative regulation of blood coagulation, extrinsic pathway

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway.


negative regulation of mitochondrial translational elongation

Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation.


negative regulation of translation in response to endoplasmic reticulum stress

Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.


positive regulation of protein neddylation

Any process that activates or increases the frequency, rate or extent of protein neddylation.


negative regulation of lymphotoxin A production

Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production.


regulation of CD86 production

Any process that modulates the frequency, rate or extent of CD86 biosynthetic process.


negative regulation of selenocysteine incorporation

Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation.


piRNA-mediated retrotransposon silencing by mRNA destabilization

A retrotransposon silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation by a piRNA.


negative regulation of translation in response to osmotic stress

Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


regulation of N-terminal peptidyl-serine acetylation

Any process that modulates the frequency, rate or extent of N-terminal peptidyl-serine acetylation.


regulation of translational frameshifting

Any process that modulates the frequency, rate or extent of translational frameshifting.


positive regulation of translation in response to osmotic stress

Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


regulation of Toll receptor ligand protein activation cascade

Any process that modulates the frequency, rate or extent of the Toll receptor ligand protein activation cascade.


negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.


positive regulation of antimicrobial peptide biosynthetic process

Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis.


positive regulation of I-kappaB phosphorylation

Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation.


negative regulation of amyloid-beta formation

Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation.


positive regulation of translational initiation by iron

Any process involving iron that activates or increases the rate of translational initiation.


positive regulation of JUN kinase activity

Any process that activates or increases the frequency, rate or extent of JUN kinase activity.


mRNA destabilization

Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.


ribosome hibernation

A cellular process that results in the silencing of ribosomes in quiescent cells. Quiescence takes place when cells encounter unfavorable conditions and cease to grow in bacteria and yeast. It also takes place in some specialized cells in higher eukaryotes, such as eggs. Ribosomes in a hibernation state are kept silent via association with proteins with inhibitory and protective functions.


regulation of exonucleolytic catabolism of deadenylated mRNA

Any process that modulates the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay.


positive regulation of translational initiation in response to stress

Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.


positive regulation of protein kinase activity

Any process that activates or increases the frequency, rate or extent of protein kinase activity.


negative regulation of protein serine/threonine phosphatase activity

Any process that stops, prevents or reduces the frequency, rate or extent of protein serine/threonine phosphatase activity.


activation of protein kinase C activity

Any process that initiates the activity of the inactive enzyme protein kinase C.


regulation of blood coagulation, common pathway

Any process that modulates the frequency, rate or extent of blood coagulation, common pathway.


regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.


regulation of protein K48-linked deubiquitination

Any process that modulates the frequency, rate or extent of protein K48-linked deubiquitination.


regulation of protein O-linked glycosylation

Any process that modulates the frequency, rate or extent of protein O-linked glycosylation.


regulation of tubulin deacetylase activity

Any process that modulates the frequency, rate or extent of tubulin deacetylase activity.


siRNA-mediated long-distance post-transcriptional gene silencing

An siRNA-mediated posttranscriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs, and in which the silencing signal originates in one tissue and occurs in a different tissue.


negative regulation of blood coagulation, intrinsic pathway

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway.


negative regulation of peptidyl-lysine crotonylation

Any process that stops or reduces the rate of crotonylation of a lysine residue in a protein.


regulation of peptidyl-serine phosphorylation of STAT protein

Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


negative regulation of histone methylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones.


positive regulation of chaperone-mediated autophagy

Any process that activates or increases the frequency, rate or extent of chaperone-mediated autophagy.


positive regulation of activation of Janus kinase activity

Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.


negative regulation of translation

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.


positive regulation of metalloendopeptidase activity

Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity.


regulation of histone H3-K4 methylation

Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.


regulation of translation at synapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating translation occurring at the synapse.


negative regulation of protein monoubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein monoubiquitination.


regulation of translation in response to osmotic stress

Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


positive regulation of histone H3-K9 acetylation

Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation.


negative regulation of N-terminal peptidyl-lysine acetylation

Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-lysine acetylation.


regulation of peptidyl-lysine acetylation

Any process that modulates the frequency, rate or extent of peptidyl-lysine acetylation.


positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.


regulation of translational initiation by eIF2 alpha dephosphorylation

Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha.


negative regulation of membrane protein ectodomain proteolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.


negative regulation of N-terminal protein palmitoylation

Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein.


positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

Any process that starts or increases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


negative regulation of glycoprotein biosynthetic process

Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.


regulation of anaphase-promoting complex-dependent catabolic process

Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


positive regulation of protein desumoylation

Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.


regulation of lipoprotein oxidation

Any process that modulates the frequency, rate or extent of lipoprotein oxidation.


negative regulation of lysosomal protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process.


activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway.


regulation of protein processing

Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein.


regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.


negative regulation of aspartic-type peptidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type peptidase activity.


nuclear polyadenylation-dependent mRNA catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA.


positive regulation of histone deacetylase activity

Any process that activates or increases the frequency, rate or extent of histone deacetylase activity.


regulation of urea metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea.


regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.


negative regulation of amide metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides.


regulation of histone modification

Any process that modulates the frequency, rate or extent of the covalent alteration of a histone.


negative regulation of CD86 production

Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process.


activation of protein kinase B activity

Any process that initiates the activity of the inactive enzyme protein kinase B.


regulation of heparan sulfate proteoglycan biosynthetic process

Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues.


negative regulation of myosin-light-chain-phosphatase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.


negative regulation of peptidyl-tyrosine autophosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.


negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.


regulation of peptide hormone processing

Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone.


positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.


negative regulation of proteoglycan biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.


negative regulation of urea catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of urea catabolic process.


sodium ion uniporter activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


membrane potential driven uniporter activity

Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


phosphate ion uniporter activity

Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


L-glutamate uniporter activity

Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


potassium ion uniporter activity

Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


purine nucleotide uniporter activity

Catalysis of the active transport of purine nucleotides across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


envenomation resulting in myocyte killing in another organism

A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).


metanephric juxtaglomerulus cell development

The process whose specific outcome is the progression of a metanephric juxtaglomerulus cell over time, from its formation to the mature structure.


juxtaglomerulus cell development

The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure.


mesonephric juxtaglomerulus cell development

The process whose specific outcome is the progression of a mesonephric juxtaglomerulus cell over time, from its formation to the mature structure.


Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate.


platelet aggregation

The adhesion of one platelet to one or more other platelets via adhesion molecules.


regulation of nitric-oxide synthase activity

Any process that modulates the activity of the enzyme nitric-oxide synthase.


positive regulation of nitric-oxide synthase activity

Any process that activates or increases the activity of the enzyme nitric-oxide synthase.


negative regulation of nitric-oxide synthase activity

Any process that stops or reduces the activity of the enzyme nitric-oxide synthase.


protein-phytochromobilin linkage

The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin.


protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine

The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine.


tRNA-dihydrouridine16 synthase activity

Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) = H+ + a uracil16 in tRNA + NAD(P)H.


beta-heterochromatin

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization.


spindle pole body-nuclear membrane anchor activity

The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in).


cellular response to vitamin B6

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.


response to vitamin B6

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.


UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity

Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H+ + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP.


glomerular capillary formation

The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.


mesonephric glomerular capillary formation

The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.


metanephric glomerular capillary formation

The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.


cellular response to interleukin-12

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.


response to interleukin-12

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.


positive regulation of leukocyte adhesion to arterial endothelial cell

Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell.


positive regulation of leukocyte adhesion to vascular endothelial cell

Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell.


positive regulation of leukocyte tethering or rolling

Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling.


negative regulation of leucine-tRNA ligase activity

Any process that stops, prevents or reduces the frequency, rate or extent of leucine-tRNA ligase activity.


A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin.


negative regulation of astrocyte activation

Any process that decreases the frequency, rate or extent of astrocyte activation.


modulation by symbiont of host salicylic acid-mediated defense response

Any process in which a symbiont modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


regulation of salicylic acid mediated signaling pathway

Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway.


positive regulation of salicylic acid mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of salicylic acid mediated signal transduction.


positive regulation by symbiont of host salicylic acid-mediated defense response

Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


symbiont-mediated suppression of defense-related host salicylic acid-mediated signal transduction pathway

A process in which a virus interferes with, inhibits or disrupts a host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


effector-mediated suppression of host salicylic acid-mediated innate immune signaling

A process mediated by a molecule secreted by a symbiont that results in the suppression of host salicylic acid-mediated innate immune signaling.


peptidyl-histidine autophosphorylation

The phosphorylation by a protein of one or more of its own histidine residues, or a histidine residue on an identical protein.


nucleotide diphosphokinase activity

Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate.


inhibitory extracellular ligand-gated monoatomic ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.


extracellularly glycine-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.


post-embryonic eye morphogenesis

The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight.


eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized.


Bolwig's organ morphogenesis

The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain.


compound eye morphogenesis

The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.


embryonic eye morphogenesis

The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.


camera-type eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.


embryonic camera-type eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized during embryonic development.


post-embryonic camera-type eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized during post-embryonic development.


positive regulation of transcription elongation by RNA polymerase I

Any process that activates or increases the frequency, rate or extent of transcription elongation from RNA polymerase I promoter.


positive regulation of DNA-templated transcription, elongation

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


histone H2AXY142 phosphatase activity

Catalysis of the reaction: histone H2AX tyrosine phosphate (position 142) + H2O = histone H2AX tyrosine (position 142) + phosphate.


histone phosphatase activity

Catalysis of the reaction: a phosphorylated histone + H2O = a protein + phosphate.


histone H2AXS140 phosphatase activity

Catalysis of the reaction: histone H2AX serine phosphate (position 140) + H2O = histone H2AX serine (position 140) + phosphate.


IgE B cell receptor complex

An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.


Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication

The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.


MacAB-TolC complex

The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC.


macrolide transmembrane transporter complex

A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes.


establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration

Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell.


DSIF complex

A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.


protein storage vacuole

A storage vacuole that contains a lytic vacuole; identified in plants.


plant-type vacuole

A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.


central vacuole

A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination.


senescence-associated vacuole

A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast.


glycyrrhetinate catabolic process

The chemical reactions and pathways resulting in the breakdown of glycyrrhetinate.


positive regulation of substance P secretion

Any process that activates or increases the frequency, rate or extent of substance P secretion.


positive regulation of peptide hormone secretion

Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


positive regulation of insulin secretion involved in cellular response to glucose stimulus

Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.


positive regulation of substance P secretion, neurotransmission

Any process that activates or increases the frequency, rate or extent of substance P secretion, neurotransmission.


positive regulation of prolactin secretion

Any process that activates or increases the frequency, rate or extent of prolactin secretion.


positive regulation of thyroid-stimulating hormone secretion

Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion.


positive regulation of corticotropin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell.


positive regulation of calcitonin secretion

Any process that activates or increases the frequency, rate or extent of calcitonin secretion.


positive regulation of corticotropin-releasing hormone secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell.


positive regulation of growth hormone secretion

Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.


positive regulation of somatostatin secretion

Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


positive regulation of glucagon secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.


positive regulation of insulin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.


transcription initiation at mitochondrial promoter

A transcription initiation process that takes place at a promoter on the mitochondrial chromosome.


excitation of vasomotor center by aortic body chemoreceptor signaling

The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.


excitation of vasomotor center by chemoreceptor signaling

The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure.


excitation of vasomotor center by carotid body chemoreceptor signaling

The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.


positive regulation of late endosome to lysosome transport

Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport.


negative regulation of neurotransmitter uptake

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.


negative regulation of serotonin uptake

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell.


negative regulation of dopamine uptake involved in synaptic transmission

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell.


inhibition of histamine uptake

Any process that prevents the activation of the directed movement of histamine into a cell.


inhibition of serotonin uptake

Any process that prevents the activation of the directed movement of serotonin into a cell.


negative regulation of catecholamine uptake involved in synaptic transmission

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell.


inhibition of neurotransmitter uptake

Any process that prevents the activation of the directed movement of a neurotransmitter into a cell.


inhibition of norepinephrine uptake

Any process that prevents the activation of the directed movement of norepinephrine into a cell.


negative regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell.


negative regulation of histamine uptake

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell.


negative regulation of amino acid uptake involved in synaptic transmission

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell.


negative regulation of glutamate uptake involved in transmission of nerve impulse

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell.


inhibition of dopamine uptake involved in synaptic transmission

Any process that prevents the activation of the directed movement of dopamine into a cell.


inhibition of acetylcholine uptake

Any process that prevents the activation of the directed movement of acetylcholine into a cell.


negative regulation of eosinophil chemotaxis

Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil chemotaxis.


midchain alkane hydroxylase activity

Catalysis of the conversion of an alkane to a secondary alcohol.


site-specific telomere resolvase activity

Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases.


m-cresol catabolic process

The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol.


Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose.


pyruvate dehydrogenase (acetyl-transferring) kinase activity

Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.


orsellinate decarboxylase activity

Catalysis of the reaction: o-orsellinate + H+ = CO2 + orcinol.


malate dehydrogenase (decarboxylating) (NADP+) activity

Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.


malic enzyme activity

Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.


malate dehydrogenase (decarboxylating) (NAD+) activity

Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.


luteolin O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H+.


L-methylmalonyl-CoA metabolic process

The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals.


The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA.


ether hydrolase activity

Catalysis of the hydrolysis of an ether bond, -O-.


Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O <=> 9,10,18-trihydroxystearate.


Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene.


glucosylglycerate hydrolase activity

Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate <=> alpha-D-glucose + D-glycerate.


juvenile hormone epoxide hydrolase activity

Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol.


leukotriene-A4 hydrolase activity

Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4).


pyrene-4,5-epoxide hydrolase activity

Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene.


cis-stilbene-oxide hydrolase activity

Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.


epoxide hydrolase activity

Catalysis of the reaction: an epoxide + H2O = a glycol.


9,10-epoxystearate hydrolase activity

Catalysis of the reaction: 9,10-epoxystearate + H2O <=> (9R,10S)-dihydroxystearate.


hepoxilin-epoxide hydrolase activity

Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate.


phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity

Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene.


phenanthrene-epoxide hydrolase activity

Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene.


mannosylglycerate hydrolase activity

Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate <=> alpha-D-mannose + D-glycerate.


Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene.


epoxide hydrolase B activity

Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers.


epoxide hydrolase A activity

Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol.


phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity

Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene.


Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol.


limonene-1,2-epoxide hydrolase activity

Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide.


aurachin C epoxide hydrolase/isomerase activity

Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H <=> aurachin B + H2O + NAD(P).


trans-epoxysuccinate hydrolase activity

Catalysis of the reaction: trans-2,3-epoxysuccinate + H2O = (2R,3S)-tartrate.


Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene.


Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde.


Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde.


isochorismatase activity

Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate.


putrescine catabolic process

The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine.


negative regulation of megakaryocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.


Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+.


phosphatidylinositol kinase activity

Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+.


Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+.


Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H+.