lateral line nerve development

The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


posterior lateral line nerve development

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


anterior lateral line nerve development

The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


trabecula formation

The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.


heart trabecula formation

The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.


spleen trabecula formation

The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod.


liver trabecula formation

The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod.


bone trabecula formation

The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod.


guanylate cyclase inhibitor activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binds to and stops, prevents or reduces the activity of guanylate cyclase.


molecular function regulator activity

A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.


acetylglutamate kinase regulator activity

Binds to and modulates the activity of acetylglutamate kinase.


channel activator activity

Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.


gonadotropin hormone-releasing hormone activity

The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary.


peptidase regulator activity

Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.


inositol phosphoceramide synthase regulator activity

Binds to and modulates the activity of inositol phosphoceramide synthase.


histone methyltransferase inhibitor activity

Binds to and stops, prevents or reduces the activity of a histone methyltransferase.


acetyltransferase activator activity

Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule.


ornithine decarboxylase activator activity

Binds to and increases ornithine decarboxylase activity.


cytoskeletal motor inhibitor activity

Binds to and stops, prevents, or reduces the activity of a motor protein.


opioid peptide activity

Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.


cyclin-dependent protein serine/threonine kinase regulator activity

Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.


transmembrane receptor protein tyrosine kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase.


chemoattractant activity involved in axon guidance

Any chemoattractant activity that is involved in axon guidance.


RNA polymerase inhibitor activity

Binds to and stops, prevents or reduces the activity of RNA polymerase.


protein kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a protein kinase.


eclosion hormone activity

The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis.


phosphatidylcholine-sterol O-acyltransferase activator activity

Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase.


pseudophosphatase activity

Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues.


cyclin-dependent protein kinase activating kinase activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).


histone deacetylase inhibitor activity

Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes.


phosphatidylinositol 3-kinase activator activity

Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K).


enzyme activator activity

Binds to and increases the activity of an enzyme.


peptidase activator activity involved in apoptotic process

Binds to and increases the activity of a peptidase that is involved in the apoptotic process.


peroxidase inhibitor activity

Binds to and stops, prevents or reduces the activity of peroxidase.


urease activator activity

Increases the activity of urease by promoting the incorporation of nickel into the active site.


phosphatidylinositol 3-kinase inhibitor activity

Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K).


morphogen activity

Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient.


melanin-concentrating hormone activity

The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals.


digestive hormone activity

The action characteristic of a hormone that takes part in the digestion process.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


adenylate cyclase regulator activity

Binds to and modulates the activity of adenylate cyclase.


Binds to and increases the activity of an endodeoxyribonuclease.


tyrosine 3-monooxygenase activator activity

Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase).


protein kinase regulator activity

Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.


mating pheromone activity

The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted.


tryptophan hydroxylase activator activity

Increases the activity of the enzyme tryptophase hydroxylase.


phospholipase inhibitor activity

Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid.


phosphatase activator activity

Binds to and increases the activity of a phosphatase.


glutamate-cysteine ligase regulator activity

Binds to and modulates the activity of glutamate-cysteine ligase.


ligase inhibitor activity

Binds to and stops, prevents or reduces the activity of a ligase.


enzyme inhibitor activity

Binds to and stops, prevents or reduces the activity of an enzyme.


melanocyte-stimulating hormone activity

The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates.


aldehyde dehydrogenase (NAD+) inhibitor activity

Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+).


[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity

Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase.


calcium sensitive guanylate cyclase activator activity

Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.


myoinhibitory hormone activity

The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction.


telomerase inhibitor activity

Binds to and stops, prevents or reduces the activity of telomerase.


protein kinase C inhibitor activity

Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein.


sodium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a sodium channel.


neurohypophyseal hormone activity

The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin.


calcium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a calcium channel.


cyclase regulator activity

Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction.


phospholipase D activator activity

Binds to and increases the activity of the enzyme phospholipase D.


ubiquitin-protein transferase inhibitor activity

Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase.


ATPase inhibitor activity

Binds to and stops, prevents or reduces an ATP hydrolysis activity.


cAMP-dependent protein kinase regulator activity

Modulation of the activity of the enzyme cAMP-dependent protein kinase.


polynucleotide adenylyltransferase activator activity

Increases the activity of the enzyme polynucleotide adenylyltransferase.


ornithine decarboxylase inhibitor activity

Binds to and stops, prevents or reduces the activity of ornithine decarboxylase.


acetylcholine receptor inhibitor activity

Binds to and stops, prevents or reduces the activity of an acetylcholine receptor.


cysteine-type endopeptidase activator activity involved in apoptotic process

Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.


phospholipase D inhibitor activity

Binds to and stops, prevents or reduces the activity of phospholipase D.


protein phosphatase regulator activity

Binds to and modulates the activity of a protein phosphatase.


receptor signaling protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.


growth hormone-releasing hormone activity

The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland.


prothoracicotrophic hormone activity

The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects.


follicle-stimulating hormone activity

The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis.


methionine adenosyltransferase regulator activity

Binds to and modulates the activity of methionine adenosyltransferase.


protein phosphatase activator activity

Binds to and increases the activity of a protein phosphatase.


lipoprotein lipase activator activity

Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein.


cyclin-dependent protein kinase activating kinase regulator activity

Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase.


deubiquitinase activator activity

Binds to and increases the activity of a deubiquitinase.


calcium-dependent protein serine/threonine phosphatase regulator activity

Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase.


pituitary adenylate cyclase activating polypeptide activity

The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation.


phospholipase activator activity

Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid.


adenylate cyclase inhibitor activity

Binds to and decreases the activity of adenylate cyclase.


cysteine-type endopeptidase activator activity

Binds to and increases the activity of a cysteine-type endopeptidase.


phosphatase regulator activity

Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.


endopeptidase activator activity

Binds to and increases the activity of an endopeptidase.


ubiquitin ligase activator activity

Binds to and increases the activity of a ubiquitin ligase.


iron ion transmembrane transporter inhibitor activity

Binds to and stops, prevents, or reduces the activity of an iron ion transmembrane transporter.


cyclin-dependent protein serine/threonine kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.


repressor of RNA polymerase inhibitor activity

Binds to and stops, prevents or reduces the activity of an RNA polymerase inhibitor.


GTPase inhibitor activity

Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.


signaling receptor activator activity

The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.


guanyl nucleotide exchange factor inhibitor activity

Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor.


competence pheromone activity

A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence.


histone deacetylase regulator activity

Binds to and modulates the activity of histone deacetylase.


death receptor agonist activity

Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor.


protein tyrosine kinase activator activity

Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.


guanylate cyclase activator activity

Binds to and increases the activity of guanylate cyclase.


protein serine/threonine kinase activator activity

Binds to and increases the activity of a protein serine/threonine kinase.


calcium channel regulator activity

Modulates the activity of a calcium channel.


DNA strand exchange activator activity

Binds to and increases a DNA strand exchange activity.


miRNA inhibitor activity via base-pairing

Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs).


L-dopa decarboxylase activator activity

Interacts with and increases L-dopa decarboxylase activity.


kinase regulator activity

Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity.


growth hormone activity

The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth.


endopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of an endopeptidase.


ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity

Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate.


ribonuclease inhibitor activity

Binds to and stops, prevents or reduces the activity of ribonuclease.


UTP:glucose-1-phosphate uridylyltransferase regulator activity

Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase.


receptor signaling protein tyrosine kinase activator activity

Binds to and increases the activity of a receptor signaling protein tyrosine kinase.


pathogen-derived receptor ligand activity

The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity.


ubiquitin-protein transferase activator activity

Binds to and increases the activity of a ubiquitin-protein transferase.


actin severing activator activity

Binds to and increases the activity of a actin severing protein.


receptor antagonist activity

The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.


cyclic nucleotide phosphodiesterase activator activity

Binds to and increases the activity of cyclic nucleotide phosphodiesterase.


cyclin-dependent protein serine/threonine kinase activator activity

Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.


calcium-dependent protein kinase regulator activity

Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner.


transcription regulator activator activity

A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification.


lipase inhibitor activity

Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.


acetylcholine receptor activator activity

Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.


RNA helicase inhibitor activity

Binds to and stops, prevents or reduces the activity of an RNA helicase.


potassium channel activator activity involved in G protein-coupled receptor signaling pathway

Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling.


ion channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of an ion channel.


ornithine carbamoyltransferase inhibitor activity

Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase.


pectinesterase inhibitor activity

Binds to and stops, prevents or reduces the activity of pectinesterase.


guanylate cyclase regulator activity

Modulates the activity of guanylate cyclase.


protein tyrosine phosphatase activator activity

Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.


ATPase activator activity

Binds to and increases the activity of an ATP hydrolysis activity.


interleukin-1 receptor antagonist activity

Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.


eukaryotic elongation factor-2 kinase regulator activity

Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase.


ion channel regulator activity

Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.


protein kinase activator activity

Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.


myosin phosphatase regulator activity

Binds to and modulates of the activity of myosin phosphatase.


exoribonuclease activator activity

Binds to and increases the activity of an exoribonuclease.


ecdysis-triggering hormone activity

The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system.


GTP cyclohydrolase I regulator activity

Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.


neuropeptide hormone activity

The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.


cysteine-type endopeptidase regulator activity involved in apoptotic process

Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.


mRNA phosphatase activator activity

Binds to and increases the activity of mRNA phosphatase.


neurotransmitter receptor regulator activity

A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing.


signaling receptor inhibitor activity

Binds to and modulates the activity of a signaling receptor.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity

Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity

Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase.


adenyl-nucleotide exchange factor activity

Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.


potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a potassium channel.


interleukin-1 type II receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 type II receptors.


kinase activator activity

Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


peptidyl-dipeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain.


Rho GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding.


metalloendopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.


phosphatidylinositol 3-kinase regulator activity

Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.


sodium channel regulator activity

Binds to and modulates the activity of a sodium channel.


enzyme regulator activity

Binds to and modulates the activity of an enzyme.


ATPase regulator activity

Binds to and modulates the activity of an ATP hydrolysis activity.


nitric-oxide synthase inhibitor activity

Binds to and stops, prevents or reduces the activity of nitric oxide synthase.


transcription regulator inhibitor activity

A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.


receptor ligand inhibitor activity

Binds to and decreases the activity of the ligand of a signaling receptor.


interleukin-1 type I receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 type I receptors.


protein phosphatase inhibitor activity

Binds to and stops, prevents or reduces the activity of a protein phosphatase.


histone acetyltransferase regulator activity

Binds to and modulates the activity of histone acetyltransferase.


small conductance calcium-activated potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel.


RNA lariat debranching enzyme activator activity

Binds to and increases the activity of an RNA lariat debranching enzyme.


1-phosphatidylinositol 4-kinase activator activity

Binds to and increases the activity of 1-phosphatidylinositol 4-kinase.


phospholipase A2 activator activity

Binds to and increases the activity of the enzyme phospholipase A2.


tRNA ligase activator activity

Binds to and increases the activity of a tRNA ligase.


channel regulator activity

Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.


acetolactate synthase regulator activity

Binds to and modulates the activity of acetolactate synthase.


calcium-dependent cysteine-type endopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner.


eukaryotic elongation factor-2 kinase activator activity

Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase.


sphingolipid activator protein activity

Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.


Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.


sphingomyelin phosphodiesterase activator activity

Binds to and increases the activity of the enzyme sphingomyelin phosphodiesterase.


activin receptor antagonist activity

Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.


outward rectifier potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel.


dolichol-phosphate-mannose synthase regulator activity

Binds to and modulates the activity of dolichol-phosphate-mannose synthase.


ion channel regulator activity involved in G protein-coupled receptor signaling pathway

Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling.


nuclease inhibitor activity

Binds to and modulates the activity of a nuclease.


polygalacturonase inhibitor activity

Binds to and stops, prevents or reduces the activity of polygalacturonase.


pheromone activity

The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant.


phosphorylase kinase regulator activity

Modulation of the activity of the enzyme phosphorylase kinase.


ribonucleoside-diphosphate reductase inhibitor activity

Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase.


transmembrane receptor protein tyrosine kinase activator activity

Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.


aspartic-type endopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases.


Binds to and modulates the activity of an NTPase.


recombinase activator activity

Binds to and increases the activity of a recombinase.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity

Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.


inward rectifier potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.


chemokine receptor antagonist activity

Interacts with chemokine receptors to reduce the action of a chemokine.


thyrotropin-releasing hormone activity

The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


chemoattractant activity

Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.


SUMO ligase regulator activity

Binds to and modulates the activity of a SUMO ligase.


fibroblast growth factor receptor antagonist activity

Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.


The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.


guiding stereospecific synthesis activity

The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis.


acetylcholine receptor regulator activity

Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.


cytoskeletal motor activator activity

Binds to and increases the activity of a motor protein.


DNA strand exchange inhibitor activity

Binds to and stops, prevents or reduces a DNA strand exchange activity.


chloride channel regulator activity

Binds to and modulates the activity of a chloride channel.


kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a kinase.


cAMP-dependent protein kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase.


signaling receptor regulator activity

Binds to and modulates the activity of a receptor.


nitric-oxide synthase regulator activity

Binds to and modulates the activity of nitric oxide synthase.


alpha-amylase inhibitor activity

Binds to and stops, prevents or reduces the activity of alpha-amylase.


myostimulatory hormone activity

The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction.


cyclase inhibitor activity

Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction.


cytoskeletal motor regulator activity

Binds to and modulates the activity of a motor protein.


G protein activity

A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).


ornithine decarboxylase regulator activity

Binds to and modulates the activity of the enzyme ornithine decarboxylase.


ubiquitin ligase inhibitor activity

Binds to and stops, prevents or reduces the activity of a ubiquitin ligase.


ecdysiostatic hormone activity

The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion.


channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a channel.


lipase activator activity

Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.


adenylate cyclase activator activity

Binds to and increases the activity of adenylate cyclase.


phosphatase inhibitor activity

Binds to and stops, prevents or reduces the activity of a phosphatase.


cyclase activator activity

Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction.


GTPase regulator activity

Binds to and modulates the activity of a GTPase.


protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a protein tyrosine kinase.


calcium-dependent protein kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase.


molecular function inhibitor activity

A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target.


phospholipase A2 inhibitor activity

Binds to and stops, prevents or reduces the activity of phospholipase A2.


ligase regulator activity

Binds to and modulates the activity of a ligase.


superoxide-generating NADPH oxidase activator activity

Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase.


diuretic hormone activity

The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion.


neuropeptide activity

The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron.


lysozyme inhibitor activity

Binds to and stops, prevents or reduces the activity of lysozyme.


deoxyribonuclease inhibitor activity

Binds to and stops, prevents or reduces the activity of deoxyribonuclease.


potassium channel regulator activity

Binds to and modulates the activity of a potassium channel.


guanyl-nucleotide exchange factor adaptor activity

The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.


dUTP pyrophosphatase inhibitor activity

Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase.


Rab GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding.


endopeptidase regulator activity

Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.


chemorepellent activity

Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.


ubiquitin-protein transferase regulator activity

Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein.


potassium channel activator activity

Binds to and increases the activity of a potassium channel, resulting in its opening.


chloride channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a chloride channel.


sulfopyruvate decarboxylase complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis.


2-butanone oxidase activity

Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate.


negative regulation of photomorphogenesis

Any process that stops, reduces or prevents photomorphogenesis.


terminal web assembly

The aggregation, arrangement and bonding together of a set of components to form a terminal web.


positive regulation of brain-derived neurotrophic factor-activated receptor activity

Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


regulation of amide metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides.


positive regulation of protein-pyridoxal-5-phosphate linkage

Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


positive regulation of kinin cascade

Any process that activates or increases the frequency, rate, or extent of the kinin cascade.


positive regulation of serine-type peptidase activity

Any process that activates or increases the frequency, rate or extent of serine-type peptidase activity.


positive regulation of cap-dependent translational initiation

Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation.


regulation of hepatocyte growth factor production

Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production.


positive regulation of CD86 production

Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process.


positive regulation of protein kinase C activity

Any process that activates or increases the frequency, rate or extent of protein kinase C activity.


regulation of translation at synapse

Any process that regulates translation occurring at the synapse.


polyadenylation-dependent mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA.


regulation of protein phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.


regulation of glucosylceramide catabolic process

Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process.


positive regulation of proteolysis associated with antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.


regulation of CD24 production

Any process that modulates the frequency, rate or extent of CD24 biosynthetic process.


positive regulation of protein autoubiquitination

Any process that activates or increases the frequency, rate or extent of protein autoubiquitination.


positive regulation of histone ubiquitination

Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein.


positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division

Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division.


negative regulation of peptidyl-tyrosine phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


negative regulation of hepatocyte growth factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production.


negative regulation of protein polyubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination.


regulation of gliotoxin biosynthetic process

Any process that modulates the frequency, rate or extent of gliotoxin biosynthetic process.


positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.


positive regulation of aspartic-type peptidase activity

Any process that activates or increases the frequency, rate or extent of aspartic-type peptidase activity.


negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.


regulation of amyloid-beta formation

Any process that modulates the frequency, rate or extent of amyloid-beta formation.


negative regulation of protein K63-linked ubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination.


positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity

Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate.


negative regulation of ubiquitin-protein transferase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity.


positive regulation of histone deubiquitination

Any process that activates or increases the frequency, rate or extent of histone deubiquitination.


positive regulation of tubulin deacetylation

Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.


negative regulation of histone H2A K63-linked ubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination.


inhibition of cysteine-type endopeptidase activity involved in apoptotic process

Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process.


positive regulation of histone H4-K16 acetylation

Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation.


positive regulation of protein catabolic process in the vacuole

Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole.


positive regulation of histone deacetylation

Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.


positive regulation of myosin light chain kinase activity

Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.


negative regulation of histone H4 acetylation

Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group.


negative regulation of peptidyl-cysteine S-nitrosylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.


positive regulation of protein histidine kinase activity

Any process that increases the frequency, rate or extent of protein histidine kinase activity.


positive regulation of histone H3-K4 methylation

Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.


negative regulation of cyclin-dependent protein kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity.


negative regulation of peptidyl-serine phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.


positive regulation of amyloid-beta formation

Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.


regulation of lysosomal protein catabolic process

Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.


regulation of cytoplasmic translational elongation

Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation.


positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Any positive regulation of proteasomal ubiquitin-dependent protein catabolic process that is involved in a cellular response to hypoxia.


positive regulation of protein deacetylation

Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


negative regulation of formation of translation initiation ternary complex

Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex.


regulation of protein glycosylation

Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.


positive regulation of translation in response to oxidative stress

Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


regulation of glucosylceramide biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


negative regulation of tyrosine phosphorylation of STAT protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


regulation of peptidyl-threonine phosphorylation

Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


negative regulation of protein glycosylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.


regulation of protein histidine kinase activity

Any process that modulates the frequency, rate or extent of protein histidine kinase activity.


negative regulation of inhibitory G protein-coupled receptor phosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.


regulation of amyloid fibril formation

Any process that modulates the frequency, rate or extent of amyloid fibril formation.


negative regulation of ferricrocin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of ferricrocin biosynthetic process.


negative regulation of peptidyl-serine dephosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation.


negative regulation of protein deubiquitination

Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein.


regulation of peptidyl-cysteine S-nitrosylation

Any process that modulates the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.


positive regulation of cap-independent translational initiation

Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation.


positive regulation of protein glycosylation

Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.


regulation of protein modification process

Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


activation of NF-kappaB-inducing kinase activity

The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.


regulation of peptidyl-tyrosine phosphorylation

Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


positive regulation of protein K63-linked ubiquitination

Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination.


miRNA-mediated gene silencing by inhibition of translation

An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs.


negative regulation of JUN kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.


negative regulation of protein modification by small protein conjugation or removal

Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal.


negative regulation of ERAD pathway

Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway.


regulation of sphingomyelin catabolic process

Any process that modulates the frequency, rate or extent of sphingomyelin catabolic process.


negative regulation of proteolysis associated with antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.


regulation of I-kappaB phosphorylation

Any process that modulates the frequency, rate or extent of I-kappaB phosphorylation.


regulation of mitochondrial translation

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


regulation of protein monoubiquitination

Any process that modulates the frequency, rate or extent of protein monoubiquitination.


regulation of PSII associated light-harvesting complex II catabolic process

Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II.


negative regulation of protein processing in phagocytic vesicle

Any process that stops, prevents or reduces the frequency, rate or extent of protein processing in phagocytic vesicle.


positive regulation of translation in response to stress

Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress.


positive regulation of tissue kallikrein-kinin cascade

Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade.


positive regulation of protein K63-linked deubiquitination

Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination.


positive regulation of serine-type endopeptidase activity

Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity.


regulation of elastin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.


positive regulation of selenocysteine incorporation

Any process that activates or increases the frequency, rate or extent of selenocysteine incorporation.


negative regulation of protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.


positive regulation of translational initiation in response to starvation

Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.


positive regulation of translational frameshifting

Any process that activates or increases the frequency, rate or extent of translational frameshifting.


negative regulation of histone H3-K9 dimethylation

Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 dimethylation.


positive regulation of protein dephosphorylation

Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.


regulation of N-terminal peptidyl-lysine acetylation

Any process that modulates the frequency, rate or extent of N-terminal peptidyl-lysine acetylation.


regulation of antibacterial peptide biosynthetic process

Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis.


regulation of protein linear polyubiquitination

Any process that modulates the frequency, rate or extent of protein linear polyubiquitination.


regulation of translational initiation in response to osmotic stress

Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


negative regulation of protein K48-linked ubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


positive regulation of protein O-linked glycosylation

Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation.


positive regulation of ubiquitin-specific protease activity

Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity.


positive regulation of proteolysis

Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.


regulation of translational initiation by iron

Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron.


siRNA-mediated gene silencing by inhibition of translation

An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs.


regulation of serine-type endopeptidase activity

Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity.


negative regulation of plasminogen activation

Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.


negative regulation of phosphoprotein phosphatase activity

Any process that stops or reduces the activity of a phosphoprotein phosphatase.


regulation of translation involved in cellular response to UV

Any regulation of translation that is involved in cellular response to UV.


regulation of angiotensin metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin.


positive regulation of cyclin-dependent protein kinase activity

Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity.


negative regulation of gliotoxin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of gliotoxin biosynthetic process.


positive regulation of peptidyl-L-cysteine S-palmitoylation

Any process that activates or increases the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation.


negative regulation of antimicrobial peptide biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis.


regulation of mitochondrial translational initiation

Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c.


activation of cysteine-type endopeptidase activity

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase.


positive regulation of plasminogen activation

Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.


negative regulation of metalloendopeptidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity.


regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.


positive regulation of translation in response to endoplasmic reticulum stress

Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.


negative regulation of histone acetylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.


regulation of Rho-dependent protein serine/threonine kinase activity

Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity.


negative regulation of blood coagulation, common pathway

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway.


regulation of CD80 production

Any process that modulates the frequency, rate or extent of CD80 biosynthetic process.


regulation of ceramide biosynthetic process

Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process.


regulation of eIF2 alpha phosphorylation by heme

Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels.


positive regulation of lipoprotein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.


regulation of blood coagulation, intrinsic pathway

Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway.


negative regulation of mitochondrial translation

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


negative regulation of ubiquitin-specific protease activity

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity.


regulation of lipoprotein lipid oxidation

Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group.


regulation of protein lipidation

Any process that modulates the frequency, rate or extent of protein lipidation.


negative regulation of peptidyl-lysine acetylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation.


positive regulation of tyrosine phosphorylation of STAT protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


translational readthrough

The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons.


positive regulation of amide catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.


regulation of histone H3-K9 trimethylation

Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation.


negative regulation of translation initiation in response to endoplasmic reticulum stress

Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.


regulation of histone H3-K9 dimethylation

Any process that modulates the frequency, rate or extent of histone H3-K9 dimethylation.


regulation of urea catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea.


regulation of peptidyl-tyrosine autophosphorylation

Any process that modulates the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.


regulation of ferricrocin biosynthetic process

Any process that modulates the frequency, rate or extent of ferricrocin biosynthetic process.


negative regulation of protein neddylation

Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation.


regulation of glutathione biosynthetic process

Any process that modulates the frequency, rate or extent of glutathione biosynthetic process.


positive regulation of peptidyl-tyrosine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.


negative regulation of peptidase activity

Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.


regulation of protein serine/threonine kinase activity

Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity.


positive regulation of histone H2A K63-linked ubiquitination

Any process that activates or increases the frequency, rate or extent of histone H2A K63-linked ubiquitination.


negative regulation of peptidyl-L-cysteine S-palmitoylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation.


regulation of low-density lipoprotein particle receptor catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors.


negative regulation of peptidyl-serine phosphorylation of STAT protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


negative regulation of protein glutathionylation

Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.


positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.


sucrose induced translational repression

Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level.


positive regulation of ubiquitin-dependent protein catabolic process

Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


negative regulation of protein desumoylation

Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.


Any process that modulates the frequency, rate or extent of regulation of ubiquitin-specific protease activity (deubiquitinase) activity.


negative regulation of I-kappaB phosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation.


positive regulation of protein lipidation

Any process that activates or increases the frequency, rate or extent of protein lipidation.


regulation of protein adenylylation

Any process that modulates the frequency, rate or extent of protein adenylylation.


regulation of translational initiation by eIF2 alpha phosphorylation

Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.


regulation of glycoprotein metabolic process

Any process that modulates the frequency, rate or extent of glycoprotein metabolic process.


negative regulation of protein lipidation

Any process that stops, prevents or reduces the frequency, rate or extent of protein lipidation.


regulation of protein desumoylation

Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.


negative regulation of protein K48-linked deubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein K48-linked deubiquitination.


regulation of proteasomal protein catabolic process

Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.


positive regulation of histone acetylation

Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.


positive regulation of translational fidelity

Any process that increases the ability of the translational apparatus to interpret the genetic code.


negative regulation of amyloid precursor protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process.


negative regulation of proteolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.


negative regulation of MAP kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.


positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation

Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation.


negative regulation of non-membrane spanning protein tyrosine kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.


regulation of histone H3-K9 methylation

Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.


negative regulation of brain-derived neurotrophic factor-activated receptor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


regulation of protein acetylation

Any process that modulates the frequency, rate or extent of protein acetylation.


regulation of cap-independent translational initiation

Any process that modulates the frequency, rate or extent of cap-independent translational initiation.


negative regulation of protein autoubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination.


negative regulation of CD80 production

Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process.


positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process.


positive regulation of histone H3-K27 trimethylation

Any process that activates or increases the frequency, rate or extent of histone H3-K27 trimethylation.


positive regulation of amyloid fibril formation

Any process that activates or increases the frequency, rate or extent of amyloid fibril formation.


regulation of translational elongation

Any process that modulates the frequency, rate, extent or accuracy of translational elongation.


negative regulation of cytoplasmic translation

Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation.


positive regulation of Toll receptor ligand protein activation cascade

Any process that activates or increases the frequency, rate or extent of Toll receptor ligand protein activation cascade.


regulation of cytoplasmic translational fidelity

Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code.


positive regulation of glycoprotein metabolic process

Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process.


negative regulation of translational elongation

Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.


regulation of protein K63-linked ubiquitination

Any process that modulates the frequency, rate or extent of protein K63-linked ubiquitination.


negative regulation of protein tyrosine phosphatase activity

Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity.


regulation of protein polyubiquitination

Any process that modulates the frequency, rate or extent of protein polyubiquitination.


positive regulation of peptidyl-tyrosine autophosphorylation

Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.


negative regulation of emericellamide biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide biosynthetic process.


positive regulation of protein oxidation

Any process that activates or increases the frequency, rate or extent of protein oxidation.


negative regulation of translational frameshifting

Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting.


positive regulation of protein activation cascade

Any process that activates or increases the frequency, rate or extent of protein activation cascade.


regulation of emericellamide A biosynthetic process

Any process that modulates the frequency, rate or extent of emericellamide A biosynthetic process.


positive regulation of peptide hormone processing

Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone.


positive regulation of protein K48-linked ubiquitination

Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination.


regulation of N-terminal peptidyl-methionine acetylation

Any process that modulates the frequency, rate or extent of N-terminal peptidyl-methionine acetylation.


regulation of myosin-light-chain-phosphatase activity

Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity.


negative regulation of cAMP-dependent protein kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.


negative regulation of kinin cascade

Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade.


positive regulation of histone H3-K9 trimethylation

Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation.


negative regulation of plasma kallikrein-kinin cascade

Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade.


positive regulation of endopeptidase activity

Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


negative regulation of protein kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.


positive regulation of cytoplasmic translational initiation

Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation.


positive regulation of CD24 production

Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process.


regulation of lymphotoxin A production

Any process that modulates the frequency, rate, or extent of lymphotoxin A production.


negative regulation of chaperone-mediated autophagy

Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy.


regulation of translation in response to endoplasmic reticulum stress

Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.


negative regulation of histone deacetylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.


positive regulation of elastin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.


regulation of plasminogen activation

Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.


negative regulation of amyloid fibril formation

Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.


selenocysteine incorporation

The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine.


negative regulation of ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


negative regulation of protein modification process

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


negative regulation of glucosylceramide biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


positive regulation of phosphoprotein phosphatase activity

Any process that activates or increases the activity of a phosphoprotein phosphatase.


regulation of cytoplasmic translational initiation

Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation.


positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.


modification by virus of host polysomes

Any viral process that interferes with and inhibits the assembly and function of polysomes.


regulation of peptidyl-L-cysteine S-palmitoylation

Any process that modulates the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation.


regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Any process that modulates the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process.


translational attenuation

Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.


positive regulation of protein ubiquitination

Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.


negative regulation of protein geranylgeranylation

Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation.


positive regulation of translational initiation

Any process that activates or increases the frequency, rate or extent of translational initiation.


regulation of protein deubiquitination

Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein.


activation of Janus kinase activity

The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.


positive regulation of peptidyl-threonine phosphorylation

Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


positive regulation of blood coagulation, intrinsic pathway

Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway.


negative regulation of cytoplasmic translational elongation

Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation.


positive regulation of protein polyglycylation

Any process that activates or increases the frequency, rate or extent of protein polyglycylation.


Factor XII activation

Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.


zymogen inhibition

Any process that prevents the proteolytic processing of an inactive enzyme to an active form.


positive regulation of mitochondrial translation in response to stress

Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress.


regulation of protein activation cascade

Any process that modulates the frequency, rate or extent of protein activation cascade.


regulation of SUMO transferase activity

Any process that modulates the frequency, rate or extent of SUMO ligase activity.


regulation of proteolysis associated with antigen processing and presentation

Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.


positive regulation of epidermal growth factor-activated receptor activity

Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity.


regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

Any process that modulates the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation.


siRNA-mediated gene silencing by mRNA destabilization

An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.


regulation of ubiquitin-dependent protein catabolic process

Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


activation of protein kinase activity

Any process that initiates the activity of an inactive protein kinase.


regulation of ERAD pathway

Any process that modulates the frequency, rate or extent of ERAD pathway.


miRNA-mediated gene silencing by mRNA destabilization

An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism.


positive regulation of translation, ncRNA-mediated

Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein.


positive regulation of protein geranylgeranylation

Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation.


negative regulation of antibacterial peptide biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis.


regulation of N-terminal protein palmitoylation

Any process that modulates the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein.


regulation of histone H4 acetylation

Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group.


regulation of protein processing in phagocytic vesicle

Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle.


negative regulation of elastin catabolic process

Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.


negative regulation of histone H3-K27 trimethylation

Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation.


regulation of amide catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.


regulation of histone H3-K9 acetylation

Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation.


regulation of translation at presynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.


regulation of tubulin deacetylation

Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.


negative regulation of protein dephosphorylation

Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.


negative regulation of emericellamide A biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide A biosynthetic process.


negative regulation of cap-independent translational initiation

Any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation.


regulation of protein processing involved in protein targeting to mitochondrion

Any process that modulates the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion.


regulation of ferrichrome biosynthetic process

Any process that modulates the frequency, rate or extent of ferrichrome biosynthetic process.


regulation of protein kinase activity

Any process that modulates the frequency, rate or extent of protein kinase activity.


regulation of oskar mRNA translation

Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex.


regulation of serine-type peptidase activity

Any process that modulates the frequency, rate or extent of serine-type peptidase activity.


negative regulation of hemoglobin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


negative regulation of translational termination

Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.


positive regulation of translation

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.


suppression by virus of host translation termination

Any viral process that stops, prevents, or reduces the frequency, rate or extent of translational termination of a host mRNA.


negative regulation of post-translational protein modification

Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification.


negative regulation by host of viral glycoprotein metabolic process

A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process.


regulation of protein oxidation

Any process that modulates the frequency, rate or extent of protein oxidation.


regulation of translational initiation

Any process that modulates the frequency, rate or extent of translational initiation.


activation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.


regulation of antimicrobial peptide biosynthetic process

Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis.


positive regulation of glutathione biosynthetic process

Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process.


regulation of protein sumoylation

Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein.


regulation of protein K63-linked deubiquitination

Any process that modulates the frequency, rate or extent of protein K63-linked deubiquitination.


regulation of histone H2A K63-linked ubiquitination

Any process that modulates the frequency, rate or extent of histone H2A K63-linked ubiquitination.


positive regulation of proteolysis involved in protein catabolic process

Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process.


regulation of lipoprotein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.


regulation of pseurotin A biosynthetic process

Any process that modulates the frequency, rate or extent of pseurotin A biosynthetic process.


regulation of brain-derived neurotrophic factor-activated receptor activity

Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


regulation of eIF2 alpha phosphorylation by dsRNA

Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA.


negative regulation of lipoprotein lipid oxidation

Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group.


regulation of cap-dependent translational initiation

Any process that modulates the frequency, rate or extent of cap-dependent translational initiation.


regulation of peptidyl-serine phosphorylation

Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.


regulation of MAP kinase activity

Any process that modulates the frequency, rate or extent of MAP kinase activity.


regulation of translational initiation in response to starvation

Any process that modulates the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.


regulation of translation at postsynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.


negative regulation of pentose-phosphate shunt

Any process that stops, prevents or reduces the frequency, rate or extent of pentose-phosphate shunt.


positive regulation of sphingomyelin catabolic process

Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process.


regulation of cAMP-dependent protein kinase activity

Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity.


negative regulation of histone H3-K9 methylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.


regulation of protein neddylation

Any process that modulates the frequency, rate or extent of protein neddylation.


regulation of protein K48-linked ubiquitination

Any process that modulates the rate, frequency or extent of protein K-48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


regulation of pentose-phosphate shunt

Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.


regulation of elastin catabolic process

Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.


regulation of histone H2B conserved C-terminal lysine ubiquitination

Any process that modulates the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination.


regulation of translation initiation in response to endoplasmic reticulum stress

Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress.


positive regulation of cytoplasmic translation

Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.


eiF2alpha phosphorylation in response to endoplasmic reticulum stress

The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.


regulation of formation of translation preinitiation complex

Any process that modulates the frequency, rate or extent of formation of translation preinitiation complex.


positive regulation of ER-associated ubiquitin-dependent protein catabolic process

Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process.