History of novel psychoactive substance misuse


Pandemic Disorder

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

An epidemic occurring worldwide, or over a very wide area, crossing international boundaries, and usually affecting a large number of people. (A dictionary of epidemiology, edited for the International Epidemiological Association by John M. Last, Oxford University Press 2001)


Other psychoactive substance abuse with other psychoactive substance-induced disorder


Unintended Movement Medical Device Problem

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Strategy

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


treatment outcome in HSR

biolink:Activity biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


response to pheromone

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.


Anorectal operation

biolink:Procedure biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


PMCH

A pro-MCH that is encoded in the genome of human.


community-acquired pneumonia severity index - class II


Individualized service provided to more than one patient in same setting


Pain management and/or control each additional 15 minutes


post-traumatic stress disorder

An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by intrusive recurring thoughts or images of the traumatic event; avoidance of anything associated with the event; a state of hyperarousal and diminished emotional responsiveness. These symptoms are present for at least one month and the disorder is usually long-term.


Radio-frequency system quality assurance device


Wound care management Team

biolink:Cohort biolink:StudyPopulation biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Umbilical cord tissue

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Specimen from urinary tract obtained by transurethral excision


solution

A mixture that is homogeneous, made up of at least two scattered molecular aggregates, one playing the role of solute and the other playing the role of solvent.


organic fundamental parent

An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system.


cerebellar vermis

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A subregion of the cerebellar cortex, consisting of the most medial zone of the cerebellar cortex, stradding the midline. May be continuous with the lateral cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissures in others (e.g., ventrally).


brain development

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


single-species biofilm formation

A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.


oxylipin

Any member of the group of bioactive lipids made by oxidation of polyunsaturated fatty acids.


epoxide

Any cyclic ether in which the oxygen atom forms part of a 3-membered ring.


A proteinase-activated receptor 3 that is encoded in the genome of mouse.


Ribosomes

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Ribosomes are small organelles composed of ribosomal RNA (rRNA) and 80 some different proteins. rRNA is synthesized in the nucleolus and the ribosomal subunits are assembled there from rRNA and imported cytoplasmic made proteins. Once assembled, the subunits pass through the nuclear pores to the cytoplasm where they take part in protein synthesis. Some ribosomes are free in the cytoplasm and can be recruited to a polyribosomal structure when a messenger RNA (mRNA) strand is to be translated into a cytoplasmic protein. Other ribosomes are attached to the endoplasmic reticulum where the protein is formed within the interior to the endoplasmic reticulum. These proteins are destined for secretion, storage or incorporation into membranes.


A dexamethasone-induced Ras-related protein 1 that is encoded in the genome of human.


peptide hormone activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Tfec

A transcription factor EC that is encoded in the genome of mouse.


A protein that is a translation product of the PRM3 gene in yeast.


United States Food and Drug Administration


Codeine

A  morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.


Disease management program (regime/therapy)


biolink:ClinicalAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


Admitted as an inpatient:Find:Pt:^Patient:Ord


services source emergency medical services (ambulance)


white American

biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Methamphetamine

A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.


Abdominal pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.


Back pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.


Initiation of patient controlled analgesia


Percutaneous incontinence-control electrical stimulation system


Administration of therapeutic medication


Leads, Electrical Stimulator, Neuromuscular


Sacral nerve stimulation test lead, each


Opioid Crisis

biolink:Phenomenon biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


prevention through information and education


Euglobulin clot lysis time within reference range


Heterogeneous Nuclear Ribonucleoprotein D0


An X-ray repair cross-complementing protein 6 that is encoded in the genome of human.


Biorepository

biolink:PhysicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:PhysicalEssenceOrOccurrent


Total arthroplasty of knee, geomedic or polycentric


Personality and behavioral disorders due to known physiological condition


office-based treatment for opioid use disorder


Maternal factors that affect newborn screening interpretation


No Matched Normal Whole Genome Sequencing Indicator


Neonatal Opiate Withdrawal Syndrome

A constellation of neurobehavioral features observed in a neonate following cessation or reduction of postnatal exposure to opioids.


Structure of posterior thalamic radiation of internal capsule


New Reynell Developmental Language Scales score


Post-Operative Pain

A sensation of discomfort secondary to surgery.


Curare alkaloid muscle relaxants, peripherally acting


Sedated

A state of a lowered level of consciousness.


enteritis

Inflammation of the small intestine.


protein MMS22-like

A protein that is a translation product of the human MMS22L gene or a 1:1 ortholog thereof.


Histiocytic ulcerative colitis of Boxer dogs


Neurodevelopmental delay

Neurodevelopmental delay (NDD) refers to delays in the maturation of the brain and central nervous system; infants and young children with NDD may experience delays in the development of one or more skills including gross motor abilities, fine-motor coordination, language abilities and ability to solve increasingly complex problems.


biomarker

A substance used as an indicator  of a biological state.


complement C3c alpha' chain fragment 2

A complement C3 alpha chain that corresponds to the C-terminal portion after proteolytic cleavage (into four chains) of complement C3b alpha' chain by factor I. Example: UniProtKB:P01024, 1321-1663.


cartilaginous projection

Anatomical projection that is composed of cartilage tissue.


Meditation-Based Stress Reduction Program


Pain severity quantified; pain present (COA) (ONC)


Modic type I vertebral endplate changes

An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1-weighted sequences and high signal on T2-weighted sequences. Modic type I changes are thought to represent bone marrow edema and inflammation.


Full-body magnetic resonance imaging system


BMF

A Bcl-2-modifying factor that is encoded in the genome of human.


ventral midline

In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate.


EUA patient assessment MISCELL MISCELLANEOUS


vertebral column disorder

A disease involving the vertebral column.


Magnetic resonance (eg, proton) imaging, spinal canal and contents, lumbar; without contrast material


Practice-Based Research Collaborative in Evidence-Based Dentistry


respiratory system

Functional system which consists of structures involved in respiration.


vagus nerve

Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart).


Neurological Disorders Depression Inventory in Epilepsy score


radiation therapy dose effective (___msv)


Pharmacotherapy for Substance Abuse Treatment, Bupropion


Cognitive behavioral therapy for psychosis


Non-physician (e.g. nurse practitioner (np), certified registered nurse anesthetist (crna), certified registered nurse (crn), clinical nurse specialist (cns), physician assistant (pa)) services in a critical access hospital


glucocorticoid

Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood.


Ocular pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye.


Headache

Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.


Stomach Cramp

An involuntary muscular contraction in the stomach. Often, this cramp is spasmodic and can be uncomfortable.


A protein that is a translation product of the human IL18 gene or a 1:1 ortholog thereof.


otolaryngologic surgical result of headache: improved


History taking, self-administered, questionnaire


LTAS_STAAM Lipoteichoic acid synthase (sprot)

A protein that is a translation product of the ltaS gene in Staphylococcus aureus subsp. aureus Mu50.


Upper respiratory tract infection due to H1N1 influenza


deuterated compound

Any isotopically modified compound that has one or more hydrogen atoms replaced by deuterium.


phenols

Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.


Immunity to tetanus by positive serology


heteroaryl hydroxy compound

Any organic aromatic compound having one or more hydroxy groups attached to a heteroarene ring.


Hapten

A substance that can act as an epitope for an antibody but that lacks immunogenicity unless coupled to a larger carrier molecule.


sympathetic ganglion

A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.


fifth lumbar dorsal root ganglion

The group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the fifth lumbar vertebra.


spinal cord injury

Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).


microglial cell activation involved in immune response

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


Molecular Major Response

A decrease in signs of cancer, supported by molecular analysis.


anorectum macrophage

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A macrophage that is located in the anorectum.


Pioglitazone

A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.


Central pain syndrome

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


sex

biolink:OrganismAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


mechanical ventilation sensitivity

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


toxic protein HokD

A protein that is a translation product of the Escherichia coli K-12 hokD gene or a 1:1 ortholog thereof.


Camp

A cathelicidin antimicrobial peptide that is encoded in the genome of mouse.


mitogen-activated protein kinase

A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY.


polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type

A protein that is a translation product of the mouse Alox12e gene or a 1:1 ortholog thereof.


Heat intolerance

The inability to maintain a comfortable body temperature in warm or hot weather.


phospholipase C-activating angiotensin-activated signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


Endosomes

A membrane bound cytoplasmic compartment that drives molecular traffic between the plasma membrane and lysosome.


Aprepitant

A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors.


spinal neuromere

A neuromere that is part of the presumptive spinal cord.


near-projecting glutamatergic cortical neuron

A glutamatergic neuron located in the cerebral cortex that projects axons locally rather than distantly.


glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA


pain disorder associated with psychological and physical factors


Neuropathic Pain

Chronic pain caused by damage to nerve fibers.  It is usually associated with tissue injury.


cellular response to abiotic stimulus

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.


TRAIL death-inducing signaling complex assembly

The aggregation, arrangement and bonding together of a set of components to form a TRAIL death-inducing signaling complex.


Indomethacin

A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.


Health Services Underutilization

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


glutamate receptor 1

An ionotropic glutamate receptor protein that is a translation product of the human GRIA1 gene or a 1:1 ortholog thereof.


Increased Sensory-Somatic Nervous System Glutamate Activity


NRCAM

A neuronal cell adhesion molecule that is encoded in the genome of human.


sensory disorder chemotherapy

biolink:Procedure biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Calcitonin-Gene Related Peptide Receptor


patient profile

biolink:Activity biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


nervous system

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].


immune system

Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies.


Peripheral Nerve Injuries

Sensory or motor loss of peripheral nerve function due to a traumatic event. (ACC)


central amygdaloid nucleus

The output region of the amygdala responsible for controlling responses (Phelps & LeDoux, 2005, http://www.ncbi.nlm.nih.gov/pubmed/ 16242399).


Naloxone

A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.


Toll-like receptor 7

A Toll-like receptor that is a translation product of the human TLR7 gene or a 1:1 ortholog thereof.


Autologous Gene-modified Gamma Delta T-cells

A preparation of genetically modified autologous gamma delta T-lymphocytes transduced with a lentiviral vector to encode a DNA repair enzyme, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous gene-modified gamma delta T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The transduction of gamma delta T-cells may confer resistance to alkylating chemotherapeutic agents including temozolomide and allow the use of gamma delta T-cells as an adjunct to these agents.


metabotropic glutamate receptor 2

A metabotropic glutamate receptor protein that is a translation product of the human GRM2 gene or a 1:1 ortholog thereof.


congenital insensitivity to pain with hyperhidrosis


dorsal root ganglion

Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain. (MSH) * ganglion found on the posterior root of each spinal nerve, composed of the unipolar nerve cell bodies of the sensory neurons of the nerve. (CSP).


Nerve Regeneration

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


A cyclin-dependent kinase 5 that is encoded in the genome of fruit fly.


dorsal horn of spinal cord

The pronounced, dorsolaterally oriented ridge of grey matter in each lateral half of the spinal cord[MP]. the dorsal (more towards the back) grey matter of the spinal cord. It receives several types of sensory information from the body, including light touch, proprioception, and vibration. This information is sent from receptors of the skin, bones, and joints through sensory neurons whose cell bodies lie in the dorsal root ganglion[WP]. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input[GO].


Fibrillary astrocyte

A neuroglial cell of ectodermic origin having long, thin, infrequently branched cytoplasmic processes containing numerous fibrillar structures. It is found mainly in the white matter of the brain.


legumain

A protein that is a translation product of the human LGMN gene or a 1:1 ortholog thereof.


oral cavity squamous cell carcinoma

A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status.


MHC-II-positive classical monocyte

Gr1-high monocyte that has a MHC-II receptor complex.


radiculopathy

Disease involving a spinal nerve root (see spinal nerve roots) which may result from compression related to intervertebral disk displacement; spinal cord injuries; spinal diseases; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.


A C-C chemokine receptor type 2 that is encoded in the genome of human.


pelargonoyl cyclic decapeptide polymyxin M(1)


complement component C5a signaling pathway

A G protein-coupled receptor signaling pathway initiated by a C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor.


G-protein coupled receptor

A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.


EC 2.1.1.6 (catechol O-methyltransferase) inhibitor

An EC 2.1.1.* (methyltransferase) inhibitor that interferes with the action of catechol O-methyltransferase (EC 2.1.1.6).


Mesenchymal Stem Cells

An undifferentiated stromal cell with the ability to develop into the cells that form distinct mesenchymal tissues; such as bone, muscle, connective tissue, blood vessels, and lymphatic tissue.


Chronic painful polyneuropathy following chemotherapy


negative regulation of opioid receptor signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway.


T cell

A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.


dihydropyrimidinase-related protein 2

A protein that is a translation product of the human DPYSL2 gene or a 1:1 ortholog thereof.


sodium channel protein type 7 subunit alpha

A voltage-gated sodium channel subunit alpha that is a translation product of the human SCN7A gene or a 1:1 ortholog thereof.


microtubule-associated protein tau sequence variant K369I (human)

A microtubule-associated protein tau sequence variant (human) that has an Ile residue at the position equivalent to Lys-369 of the amino acid sequence represented by UniProtKB:P10636-8 (Tau-F; aka Lys-686 in PNS-Tau). Example: UniProtKB:P10636-8, Lys-369, CHEBI:30009.


clathrin coat assembly

The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.


A transient receptor potential cation channel subfamily M member 3 that is encoded in the genome of human.


Isoquercetin

A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells


Primidone

A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an  anticonvulsant for treatment of various types of seizures.


A transient receptor potential cation channel TRPV1 that is encoded in the genome of human.


trigeminal nuclear complex

The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP].


Stomatognathic System

The mouth, jaws, and other related structures that are involved in speech, mastication, and deglutition.


Structure of spinal sensory afferent system


A substance-P receptor that is encoded in the genome of human.


plasma membrane

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.


A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof.


complex regional pain syndrome

Complex regional pain syndrome (CRPS) is a rare neurologic disease painful progressive condition that corresponds to a group of disorders characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.


transforming growth factor beta receptor signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


CRISPR-Associated Protein Complex Proteins


CARTPT

A cocaine- and amphetamine-regulated transcript protein that is encoded in the genome of human.


A probable G-protein coupled receptor 160 that is encoded in the genome of mouse.


transient receptor potential cation channel TRPA1

A transient receptor potential cation channel TRPA that is a translation product of the human TRPA1 gene or a 1:1 ortholog thereof.


phospholipase C-activating rhodopsin mediated signaling pathway

A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by a rhodopsin molecule being activated by a photon, and ending with the regulation of a downstream cellular process, e.g. transcription.


A phospholipid-transporting ATPase ABCA1 that is encoded in the genome of human.


apolipoprotein A-I-binding protein

A protein that is a translation product of the human NAXE gene or a 1:1 ortholog thereof.


Microglia

A type of glial cell that mediates immune responses by clearing cellular debris and dead neurons from nervous tissue through phagocytosis.


cholesterol metabolism

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Mitochondria

Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Mitochondria contain distinctive ribosomes, transfer RNAs, amino acyl t-RNA synthetases, and elongation and termination factors. Mitochondria depend upon genes within the nucleus for many essential messenger RNAs. Mitochondria consist of two sets of membranes, a smooth continuous outer coat and an inner membrane arranged in tubules or more often in folds that form platelike double membranes (cristae). Mitochondria are the principal energy source of the cell and contains the cytochrome enzymes of terminal electron transport and the enzymes of the citric acid cycle, fatty acid oxidation, and oxidative phosphorylation. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP.


mitochondrial fission factor

A protein that is a translation product of the human MFF gene, a 1:1 ortholog thereof, or pro-orthologs thereof.


Adm

A pro-adrenomedullin that is encoded in the genome of mouse.


Molecular Response

An evaluation of the molecular response of the disease to the therapy.


transient receptor potential cation channel TRPV4

A transient receptor potential cation channel TRPV that is a translation product of the human TRPV4 gene or a 1:1 ortholog thereof. The functional subunits are ion-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification.


indifference to pain, congenital, autosomal dominant


CTSS

A cathepsin S that is encoded in the genome of human.


heat shock protein beta-3

An HSPB protein that is a translation product of the human HSPB3 gene or a 1:1 ortholog thereof.


hereditary thermosensitive neuropathy

Hereditary thermosensitive neuropathy is a rare, demyelinating, hereditary motor and sensory neuropathy characterized by reversible episodes of ascending muscle weakness, paresthesias and areflexia triggered by a febrile episode, with or without pressure palsy.


AP-2 complex subunit alpha-2

A protein that is a translation product of the human AP2A2 gene or a 1:1 ortholog thereof.


sexual identity is different from one's anatomic sex


autonomic nervous system

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO].


Astrocytes

A heterogeneous group of specialized neuroglial cells with many diverse supporting roles in the structure, function, and homeostasis of the central nervous system.


astrocyte activation involved in immune response

A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.


spike train

A series of sequential, propagated action potentials occurring in a single cell.


Norepinephrine

The R-enantiomer of noradrenaline.


cluster headache, familial

An instance of cluster headache syndrome that is caused by an inherited modification of the individual's genome.


evoked neurotransmitter secretion

Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential.


A short transient receptor potential cation channel TRPC4 that is encoded in the genome of human.


Mitochondrial inheritance

A mode of inheritance that is observed for traits related to a gene encoded on the mitochondrial genome. Because the mitochondrial genome is essentially always maternally inherited, a mitochondrial condition can only be transmitted by females, although the condition can affect both sexes. The proportion of mutant mitochondria can vary (heteroplasmy).


sodium channel activity

Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.


synaptic transmission, glutamatergic

The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


neurotensin receptor type 2

A neurotensin receptor that is a translation product of the human NTSR2 gene or a 1:1 ortholog thereof. This receptor has a low affinity for neurotensin compared with neurotensin receptor 1 and neurotensin binding is selectively blocked by levocabastine.


A voltage-dependent calcium channel subunit alpha-2/delta-3 that is encoded in the genome of rat.


enterocyte of colon

A columnar cell of the colon that is part of the colonic epithelium.


Early endosome

The endosomal compartment that fuses with endocytic vesicles and sorts the plasma membrane components from any internalized molecules that are targeted for lysosomal degradation.


proteolysis within endosome associated with antigen processing and presentation

The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation.


colitis

Inflammation of the colon.


inactive serine protease RAMP

A protein that is a translation product of the human PAMR1 gene or a 1:1 ortholog thereof.


plasmacytoid dendritic cell activation involved in immune response

A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.


nitric oxide-cGMP-mediated signaling pathway

Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.


protein kinase C

A protein that is a protein kinase C either from calcium-dependent, calcium-independent or atypical or proteinsa Ser/Thr protein kinases that control many different aspects of neuronal function. Contains(Pfam:PF00168), a Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433).


G protein-coupled opioid receptor signaling pathway

A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


CD8-Positive T-Lymphocytes

A subset of T-lymphocytes that express the CD8 surface glycoprotein and bind epitopes that are part of class I histocompatibility molecules. CD8-positive T-lymphocytes include cytotoxic T-lymphocytes and CD8+ suppressor T-lymphocytes.


A protein that is a translation product of the human IL13 gene or a 1:1 ortholog thereof. Interleukin-13 is a pleiotropic cytokine which may be important in the regulation of the inflammatory and immune responses. It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related.


A T-cell immunoglobulin and mucin domain-containing protein 4 that is encoded in the genome of human.


OXT

An oxytocin-neurophysin 1 that is encoded in the genome of human.


Ammon's horn

A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum.


A peptidyl-prolyl cis-trans isomerase FKBP5 that is encoded in the genome of mouse.


nuclear factor erythroid 2-related factor 2

A protein that is a translation product of the human NFE2L2 gene or a 1:1 ortholog thereof.


cerebellum

Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA].


trigeminal ganglion

The cranial ganglion that is associated with and extends fibers into the trigeminal nerve.


CTRC

A chymotrypsin-C that is encoded in the genome of human.


Mas-related G-protein coupled receptor A1

A Mas-related G-protein coupled receptor A that is a translation product of the mouse Mrgpra1 gene or a 1:1 ortholog thereof. RF-amide-related peptides are reported to be the preferred ligands.


facial neuralgia

Neuralgic syndromes which feature chronic or recurrent facial pain as the primary manifestation of disease. Disorders of the trigeminal and facial nerves are frequently associated with these conditions.


Unilateral cleft lip

A non-midline cleft of the upper lip on one side only.


A G-protein coupled bile acid receptor 1 that is encoded in the genome of mouse.


urinary bladder

Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP].


interstitial cystitis

A rare chronic debilitating urogenital disease characterized by urinary frequency, urgency, and pelvic pain.


overactive bladder

Symptom of overactive detrusor muscle of the urinary bladder that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. urinary incontinence may or may not be present.


Hypoxic ischemic encephalopathy of newborn


spastic cerebral palsy

A form of cerebral palsy wherein spasticity is the exclusive impairment present.


Home infusion therapy, immunotherapy, administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem


14-3-3 protein gamma

A 14-3-3 protein that is a translation product of the human YWHAG gene or a 1:1 ortholog thereof.


adenylate cyclase-inhibiting opioid receptor signaling pathway

An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor, and ending with the regulation of a downstream cellular process.


A kappa-type opioid receptor that is encoded in the genome of rat.


islet amyloid polypeptide

A protein that is a translation product of the human IAPP gene or a 1:1 ortholog thereof.


Metabolic Response

An evaluation of the metabolic response of the disease to the therapy.


Bone pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.


neurotrophin TRK receptor signaling pathway

The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.


AAK1 gene translation product

A protein that is a translation product of the human AAK1 gene or a 1:1 ortholog thereof.


clathrin-dependent endocytosis

An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.


cytotoxicity

The adverse effect of some iatrogenic therapies. It is an accepted side effect in radiation therapy where the desired effect is to kill rapidly growing tumor cells.  In the killing of tumor cells, other cells that are rapidly growing e.g hair, mucous membranes are also killed.


locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.


Hydromorphone

A  morphinane alkaloid that is a hydrogenated ketone derivative of morphine. A semi-synthetic drug, it is a centrally acting pain medication of the opioid class.


Age more than 40 years, hispanic american


PHYSICIAN VISITS WITH EVALUATION AND MANAGEMENT SERVICES


opiate dependence

Disorders related or resulting from abuse or mis-use of opioids.


biolink:ClinicalAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


microtubule-associated protein tau sequence variant R448* (human)

A microtubule-associated protein tau sequence variant (human) that has a premature stop at the position equivalent to Arg-448 of the amino acid sequence represented by UniProtKB:P10636-1 (PNS-Tau; residue encoded within an exon missing from Tau-F). Example: UniProtKB:P10636-1, 1-447.


substance use therapy for drug withdrawal


Relapse

biolink:Phenomenon biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Substance Abuse Treatment @ None @ Pharmacotherapy


Sexual Partners

biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Rewards and contingency management therapy


contingency plans action therapy medication


nursing care: respiratory therapy oxygen status 'no smoking' sign


hormone

Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.


thought processes executive functions cognitive flexibility


Living with HIV/AIDS

biolink:Cohort biolink:StudyPopulation biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Stimulant abuse

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


RNAx administer substance abuse screening test


Mental and behavioral disorders due to multiple drug use and use of psychoactive substances, dependence syndrome


tobacco use disorder with other mental and behavioral disorders


Problems related to other psychosocial circumstances


Are you always able to stop using drugs when you want to:Find:Pt:^Patient:Ord:SAMHSA


ALCOHOL AND/OR DRUG SERVICES; ACUTE DETOXIFICATION (HOSPITAL INPATIENT)


alcohol use with alcohol-induced disorder


Medication Management for Substance Abuse Treatment, Other Replacement Medication


medication management by pharmacist, each additional 15 minutes


Drug addiction therapy using buprenorphine


Patient Protection and Affordable Care Act


Patient discharged against medical advice:Find:Pt:^Patient:Ord:CMS Assessment


Hospitalist services (list separately in addition to code for appropriate evaluation and management service)


psychoactive substance use, uncomplicated


prevention or treatment implementation fidelity


A tertiary alcohol that is cyclohexanol substituted at positions 1 and 2 by 3-methoxyphenyl and dimethylaminomethyl groups respectively.


Health behavior intervention, individual, face-to-face; each additional 15 minutes (List separately in addition to code for primary service)


M+N+ phenotype

biolink:OrganismAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


age of patient

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


opioid use with specified opioid-induced disorder


Mental and behavioral disorders due to use of tobacco, other mental and behavioral disorders


Patients with an active diagnosis or history of cancer (except basal cell and squamous cell skin carcinoma), patients who are heavy tobacco smokers, lung cancer screening patients


Encounter due to Imprisonment and other incarceration


Multiple physiological parameter spot-check analysis system, home-use


Drug groups primarily used in obstetrics, gynaecology and urinary tract disorders


Interview, history AND/OR physical examination


drug screen for three or four opioids and opiate analogs


Pharmacotherapy for Substance Abuse Treatment, Methadone Maintenance


Electronic clinical breast examination system


susceptibility to HIV infection

The type species of lentivirus and the etiologic agent of acquired immunodeficiency syndrome (AIDS). It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.


A CTP synthase 1 that is encoded in the genome of mouse.


Wilms Tumor 1 Gene Syndromes

A group of syndromes caused by autosomal dominant mutation(s) in the WT1 gene, encoding Wilms tumor protein. Patients with this mutation may have a predisposition to developing Wilms tumors.


adult organism

A multicellular organism that existence_ends_with a post-juvenile adult stage and existence_starts_with a post-juvenile adult stage.


hospital medical services-primary physician


Other psychoactive substance dependence with other psychoactive substance-induced disorder


Controlled substance use prevention individual each 15 minutes


unspecified psychoactive substance dependence using combination of drugs, continuous


Facility (object)

biolink:PhysicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:PhysicalEssenceOrOccurrent


Information Systems, Data Management, Hospital, Integrated


patient is NPO prior to admission to hospital


acute disease

Disease having a short and relatively severe course.


Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure


Patient suffering from severe mental impairment under the Mental Health Act 1983 (England and Wales)


psychoactive substance abuse with psychoactive substance-induced disorder


VhaSFD

A V-type proton ATPase subunit H that is encoded in the genome of fruit fly.


opioid use with other opioid induced mental and behavioral disorders


At risk for negative response to medication


amphetamines

Amines that constitute a class of central nervous system stimulants based on the structure of the parent amphetamine 1-phenylpropan-2-amine.


drug and alcohol detoxification and rehabilitation


Clinical Response

An evaluation of the clinical response of the disease to the therapy.


Early intervention in psychosis - Daily intensive


Chemical, drug or biological product, NOS


Assessment of risk for hospital acquired complication


Hospital inpatient or observation discharge day management; more than 30 minutes on the date of the encounter


primary motor cortex

The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html.


cocaine abuse

Disorders related or resulting from use of cocaine.


mental disorder

A disease that has its basis in the disruption of mental process.


Physical addiction

The neuroadaptation of the body to the presence of an opioid, and is characterized by the onset of acute symptoms and signs of withdrawal if the opioid is stopped or an opioid antagonist is administered.


Take-home supply of methadone; up to 7 additional day supply (provision of the services by a medicare-enrolled opioid treatment program); list separately in addition to code for primary procedure


Maintaining and protecting the patient's autonomy, dignity, and human rights


urine

Excretion that is the output of a kidney.


Bupropion

An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.


NCI Drug Resistance and Sensitivity Network


Combined opportunistic and cohort screening


Lumbar-sacral orthosis, sagittal-coronal control, rigid shell(s)/panel(s), posterior extends from sacrococcygeal junction to t-9 vertebra, anterior extends from symphysis pubis to xyphoid, produces intracavitary pressure to reduce load on the intervertebral discs, overall strength is provided by overlapping rigid material and stabilizing closures, includes straps, closures, may include soft interface, pendulous abdomen design, prefabricated, off-the-shelf


Complementary or Alternative Medical Procedure


digital therapeutics,cognit. behavioral therapy for ADHD MISCELL MISCELLANEOUS


Disorder in remission in response to treatment


RNAx administer drug abuse screening test


Exploratory Investigational New Drug Study


nicotine dependence

Physical and psychological dependence on nicotine.


Was there ever a time when two or more of these problems occurred together:Find:Pt:^Patient:Ord:SSAGA II


Did you have to use this drug to make problems go away 3 or more times:Find:Pt:^Patient:Ord:SSAGA II


other lab test for the psychological system


Young Person's Clinical Outcomes in Routine Evaluation


Undefined Oriental herb and natural substance letter X narrative required


Oriental herb and/or natural substance preparation training group each 15 minutes


Medication assisted treatment, buprenorphine (implant insertion and removal); weekly bundle including dispensing and/or administration, substance use counseling, individual and group therapy, and toxicology testing if performed (provision of the services by a medicare-enrolled opioid treatment program)


screening for AODE and/or AODR disorders


Office-based treatment for opioid use disorder, including development of the treatment plan, care coordination, individual therapy and group therapy and counseling; at least 70 minutes in the first calendar month


integration of AOD use in every day life and contexts


Esrd demo expanded bundle including venous access and related services


School-based individualized education program (iep) services provided outside the public school district responsible for the student


Nausea

A sensation of unease in the stomach together with an urge to vomit.


Vomiting

Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.


Infectious disease, chronic hepatitis C virus (HCV) infection, six biochemical assays (ALT, A2-macroglobulin, apolipoprotein A-1, total bilirubin, GGT, and haptoglobin) utilizing serum, prognostic algorithm reported as scores for fibrosis and necroinflammatory activity in liver


Chronic hepatitis C co-occurrent with human immunodeficiency virus infection


Patient did not start or is not receiving antiviral treatment for Hepatitis C during the measurement period (HEP-C)


borderline personality disorder

A disorder characterized by an enduring pattern of unstable self-image and mood together with volatile interpersonal relationships, self-damaging impulsivity, recurrent suicidal threats or gestures and/or self-mutilating behavior.


major depressive disorder

An episode of depression lasting two or more weeks without an intervening episode of mania.


Medical Dictionary for Regulatory Activities Terminology (MedDRA)


Nuclear medicine system table, non-powered


False Positive

A test result that shows evidence of a result or condition although it is not actually present.


Emergency department healthcare professional


A vitamin K-dependent protein S that is encoded in the genome of human.


opioid abuse with opioid-induced disorder


Food and nutrient intake panel:-:Point in time:^Patient:-


Ehlers-Danlos syndrome, autosomal dominant, type unspecified


Medication Management for Substance Abuse Treatment, Psychiatric Medication


EDA

An ectodysplasin-A that is encoded in the genome of human.


PDYN

A proenkephalin-B that is encoded in the genome of human.


Disease remission

A decrease in or disappearance of signs and symptoms typically associated with a disease course.


healthcare associated pertussis without pneumonia


Psychoactive substance use disorder, NOS


Home therapy, intermittent anti-emetic injection therapy; administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem


cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies

A autosomal recessive cutis laxa type I that has material basis in homozygous or compound heterozygous mutation in the LTBP4 gene on chromosome 19q13


Patient Reported Outcomes Version of CTCAE


CRS/HIPEC Completeness of Cytoreduction Score


Waiver services; not otherwise specified (nos)


Ophthalmic surgical microscope data overlay unit


PPCS

A phosphopantothenate--cysteine ligase that is encoded in the genome of human.


Subject selection and withdrawal section:-:-:^Clinical trial protocol:Nar


Remifentanil

A piperidinecarboxylate ester that is methyl piperidine-4-carboxylate in which the hydrogen attached to the nitrogen is substituted by a 3-methoxy-3-oxopropyl group and the hydrogen at position 4 is substituted the nitrogen of N-propanoylaniline.


Liquid Chromatography/Tandem Mass Spectrometry


alkaloid

Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is  exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.


kappa-type opioid receptor

An opioid receptor protein that is a translation product of the human OPRK1 gene or a 1:1 ortholog thereof. The preferred ligand is dynorphin.


release of sequestered calcium ion into cytosol by Golgi

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol.


morphine receptor activity

Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein.


indole alkaloid

An alkaloid containing an indole skeleton.


Withdrawal (dysfunction)

A social or emotional detachment, pathological retreat from objective reality, interpersonal contact and social involvement, as in some forms of schizophrenia, depression, or schizoid, avoidant, or schizotypal personality disorders.


AOD preference

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


HOME CARE AND SOCIAL SERVICES

biolink:Procedure biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Resting State Functional Connectivity Magnetic Resonance Imaging


Increased Arden ratio of electrooculogram

An abnormal increase in the Arden ratio, which is the ratio between the light peak and the dark trough of the smoothed (physiologic) EOG record.


Phenylpiperidine derivatives, opioid analgesics


blood plasma

The liquid component of blood, in which erythrocytes are suspended.


urea herbicide

An herbicide which is primarily composed of urea (also known as carbamide).


A nucleoporin SEH1 that is encoded in the genome of mouse.


G protein activity

A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).


desensitization of G protein-coupled receptor signaling pathway by arrestin

The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins.


A mu-type opioid receptor that is encoded in the genome of mouse.


drug screen stereoisomer analysis of single drug class


Detectors, Environmental, Biological Agent, Remote Sensing


hypocretin neuropeptide precursor

A protein that is a translation product of the human HCRT gene or a 1:1 ortholog thereof.


bridged compound

A polycyclic compound in which two rings have two or more atoms in common.


3-hydroxy carboxylic acid

Any hydroxy carboxylic acid which contains a hydroxy group located beta- to the carboxylic acid group.


Hydroxy acid and/or hydroxy acid derivative


diluent for naltrexone microspheres (carboxymethylcellulose) INTRAMUSC VIAL (ML)


Respiratory distress

Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.


An NADPH-dependent diflavin oxidoreductase 1 that is encoded in the genome of mouse.


ventral tegmental area

Unpaired midbrain region situated in the ventromedial portion of the reticular formation. The VTA is medial to the substantia nigra and ventral to the red nucleus, and extends caudally from the posterior hypothalamus in the diencephalon. The VTA contains dopamine neurons that project to various limbic and cortical areas and is a critical component of the brain's reward circuitry.


objective opioid withdrawal scale (OOWS)


Lower GI Progression GvHD

An NIH lower GI score that has increased by 1 or more points, except 0 to 1.


analgesic

An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.


Neurostimulation of intracranial ganglion


Impaired acid inhibition of gastrin release


Carfentanil

A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of methyl 4-anilino-1-(2-phenylethyl)piperidine-4-carboxylate with propanoic acid.


Sufentanil

An anilide resulting from the formal condensation of the aryl amino group of 4-(methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid.


Drug Overdose

Exposure to, or intake of, an excessive amount of a substance.


sleep disorder

A change from the patient's baseline sleeping pattern, in the hours slept and/or an alteration/dysfunction in the stages of sleep.


Pokeweed mitogen hypersensitivity each item


Stress

The negative mental, emotional, and physical reactions that occur when environmental stressors are perceived as exceeding the individual's adaptive capacities.


regulator of G-protein signaling 4

A protein that is a translation product of the human RGS4 gene or a 1:1 ortholog thereof.


asperthecin metabolic process

The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans.


A cytochrome P450 2D6 that is encoded in the genome of human.


Product containing glucagon-like peptide 1 receptor agonist (product)


Transcutaneous stimulation of cervical branch of vagus nerve


Emotional Distress

Disturbed mental state characterized by moodiness, irritability, agitation, anxiety, and/or depression resulting from physical or mental stress.


endothelial microparticle formation

The cellular component organization process in which microparticles bud off from an endothelial cell.


Polylactic Acid-Polyglycolic Acid Copolymer


Pharmacotherapy for Substance Abuse Treatment, Naltrexone


Decreased patellar reflex

Decreased intensity of the patellar reflex (also known as the knee jerk reflex).


wrist pain elicited by Finkelstein's test


leptin

A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof.


CRP

A C-reactive protein that is encoded in the genome of human.


Chronic Prostatitis with Chronic Pelvic Pain Syndrome


Historically Controlled Study

biolink:Activity biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


intervention using evidence-based techniques


Dialysis training, patient, including helper where applicable, any mode, completed course


Noc drugs, other than inhalation drugs, administered through dme


Therapeutic interventions that focus on cognitive function (eg, attention, memory, reasoning, executive function, problem solving, and/or pragmatic functioning) and compensatory strategies to manage the performance of an activity (eg, managing time or schedules, initiating, organizing, and sequencing tasks), direct (one-on-one) patient contact; each additional 15 minutes (List separately in addition to code for primary procedure)


HCST

A hematopoietic cell signal transducer that is encoded in the genome of human.


CHILD syndrome

CHILD syndrome (Congenital Hemidysplasia with Ichthyosiform nevus and Limb Defects, CS) is an X-linked dominant genodermatosis characterized by unilateral inflammatory and scaling skin lesions with ipsilateral visceral and limb anomalies.


Antidepressants, serotonergic class; 1 or 2


Pregnant

Observed to be or have been pregnant.


Measurement of Cognitive Linguistic Ability score


Breech presentation

A position of the fetus at delivery in which the fetus enters the birth canal with the buttocks or feet first.


polycystic kidney disease

A usually autosomal dominant and less frequently autosomal recessive genetic disorder characterized by the presence of numerous cysts in the kidneys leading to end-stage renal failure. The autosomal dominant trait is associated with abnormalities on the short arm of chromosome 16. Symptoms in patients with the autosomal dominant trait usually appear at middle age and include abdominal pain, hematuria, and high blood pressure. Patients may develop brain aneurysms and liver cysts. Patients with the autosomal recessive trait present with progressive renal failure early in life and symptoms resulting from hepatic fibrosis. The autosomal recessive trait is associated with abnormalities of chromosome 6. Polycystic kidney disease may also result as a side effect in patients on renal dialysis.


chronic kidney disease

Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.


Opioid-Induced Constipation

Constipation that results from, or follows, treatment with an opioid or opioid-containing medication.


Multi-modal Acceptance and Commitment Therapy


Goal setting assistance group each 60 minutes


Housing instability due to frequent change in place of residence


Behavioral health outreach service (planned approach to reach a targeted population)


aftercare following surgery of skin and subcutaneous tissue


Rural/outside providers' customary service area


community resources substance abuse treatment center


maladaptive health behaviors affecting physical condition


fronto-orbital sulcus

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Hepatitis C Virus RNA Positive

An indication that hepatitis C RNA has been detected in a sample.


abnormal preoccupation only interested in same few toys or objects


preventive medicine medication prescribed for age-related eye disease study


Department of veterans affairs whole health partner services


BEHAVIORAL HEALTH COUNSELING AND THERAPY, PER 15 MINUTES


Integrated mental health/substance abuse program


Take-home supply of buprenorphine (oral); up to 7 additional day supply (provision of the services by a medicare-enrolled opioid treatment program); list separately in addition to code for primary procedure


Physician provider services in a physician scarcity area


Community disaster preparedness (procedure)


Other psychoactive substance use, unspecified with psychoactive substance-induced sexual dysfunction


An adenylosuccinate synthetase isozyme 2 that is encoded in the genome of mouse.


Most recent admission &or entry or reentry into this facility


Injection Site

The anatomic site at which a medication or a vaccine is injected.


Are you hispanic, latino-a, or of spanish origin:Finding:Point in time:^Patient:Nominal


Spiritual nurse rest facilitation each 15 minutes


Purchased Services, Ancillary Support, Relocation


Medication adherence telemetric monitoring system


Transcutaneous electrical nerve stimulator


Monitors, Telemetric, Physical Activity/Physiologic


psychometric Millon clinical multiaxial inventory


Patient monitoring system module, data memory


voltage-dependent calcium channel subunit alpha-2/delta-1

A protein that is a translation product of the human CACNA2D1 gene or a 1:1 ortholog thereof.


hyaline cartilage tissue

Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.


smad5 isoform 1 phosphorylated form

A smad5 isoform 1 that includes at least one phosphorylated residue.


Hormones and their metabolites and precursors T - Z


voltage-gated sodium channel protein

A voltage-gated ion channel protein that has voltage-gated sodium channel activity. A voltage-gated sodium channel enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


Evoked electrical activity of brain

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Triggered by heat

Applies to a sign or symptom that is provoked or brought about by exposure to heat.


peripheral nervous system neuron

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A neuron that is part of a peripheral nervous system.


neural tissue

Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature.


Gastro-resistant oral granules (dose form)


BMP signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


Autologous Mesenchymal Stem Cells-Poly Lactic-co-glycolic Acid

A preparation of autologous bone marrow derived mesenchymal stem cells (MSC) that are seeded on biodegradable poly lactic-co-glycolic acid (PLGA)-containing polymer scaffolds, that can potentially be used for bone marrow engraftment. When administered into the bone lesion of the patient, the autologous MSC-PLGA can be used for bone marrow engraftment.


bone element

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Skeletal element that is composed of bone tissue.


high voltage-gated calcium channel activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.


Constant current

biolink:Phenomenon biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


digital therapeutics for cancer drug therapy optimization


drug screen method nonchromatographic single class procedure


A eukaryotic translation initiation factor 5 that is encoded in the genome of mouse.


Reproductive Human Cells, Tissues, and Cellular and Tissue-Based Products from Known Donor to Directed Recipient


hypusine metabolic process

The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.


A serine/threonine-protein kinase 25 that is encoded in the genome of human.


A cAMP-dependent protein kinase type I-alpha regulatory subunit that is encoded in the genome of rat.


5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1 (rat)

A 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1 in rat. UniProtKB:P54645, Thr-183, MOD:00047.


cAMP-dependent protein kinase type 1

A protein that is a translation product of the yeast TPK1 gene or a 1:1 ortholog thereof.


Medical home program, comprehensive care coordination and planning, maintenance of plan


Symptom

Subjective evidence of disease perceived by the patient.


health maintenance unlisted preventive medicine service


Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels


A P2X purinoceptor 7 (mouse) that is encoded in the genome of mouse that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:C8YIX4. This form is shorter compared to isoform a.


anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody/fowlpox-PSA-TRICOM vaccine/sargramostim/vaccinia-PSA-TRICOM vaccine


A rodent-type Mas-related G-protein coupled receptor X1 that is encoded in the genome of rat.


thienopyrimidine

A class of aromatic heterobicyclic compounds each of which contains a pyrimidine ring ortho fused to a 5-membered thiophene ring.


spinal cord

Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).


Dermal substitute, native, non-denatured collagen, neonatal bovine origin (surgimend collagen matrix), per 0.5 square centimeters


obstructive sleep apnea syndrome

Cessation of air flow during sleep due to upper airway obstruction.


Rigidity

Continuous involuntary sustained muscle contraction. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from muscle spasticity.


Oxygen Consumption

biolink:ClinicalAttribute biolink:Attribute biolink:NamedThing biolink:OntologyClass


Acupuncture Nurse

biolink:Cohort biolink:StudyPopulation biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


fibromyalgia

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation.


Fatigue

A subjective feeling of tiredness characterized by a lack of energy and motivation.


English (ethnic group)

biolink:PopulationOfIndividualOrganisms biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:SubjectOfInvestigation biolink:ThingWithTaxon


Vulnerable adult

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to gc/ms (any type, single or tandem) and lc/ms (any type, single or tandem and excluding immunoassays (e.g., ia, eia, elisa, emit, fpia) and enzymatic methods (e.g., alcohol dehydrogenase)), (2) stable isotope or other universally recognized internal standards in all samples (e.g., to control for matrix effects, interferences and variations in signal strength), and (3) method or drug-specific calibration and matrix-matched quality control material (e.g., to control for instrument variations and mass spectral drift); qualitative or quantitative, all sources, includes specimen validity testing, per day; 1-7 drug class(es), including metabolite(s) if performed


Behavior modification assistance individual each 15 minutes


Medication Management for Substance Abuse Treatment, Naloxone


Withdrawn from alcohol detoxification program


Prescription drug monitoring, evaluation of drugs present by LC-MS/MS, using oral fluid, reported as a comparison to an estimated steady-state range, per date of service including all drug compounds and metabolites


Adult onset

Onset of disease manifestations in adulthood, defined here as at the age of 16 years or later.


Overdose of non-opiate analgesics of undetermined intent


Anxiety disorder of childhood OR adolescence


Poisoning by, adverse effect of and underdosing of other opioids


A disorder characterized by a marked pattern of inattention and/or hyperactivity-impulsivity that is inconsistent with developmental level and clearly interferes with functioning in at least two settings (e.g. at home and at school). When present, the symptoms of hyperactivity are most often present before the age of 7 years. There are three recognized presentations or subtypes from most to least common: combined type, inattentive/distractible type, hyperactive/impulsive type.


Drug therapy for attention deficit hyperactivity disorder


Non-stimulant drug therapy for attention deficit hyperactivity disorder


Live Birth

The complete expulsion or extraction from the mother of a fetus, irrespective of the duration of pregnancy, which, after such expulsion or extraction, breathes or shows any other evidence of life, such as beating of the heart, pulsation of the umbilical cord, or definite movement of voluntary muscles.


Pain - care area triggered:Find:Pt:^Patient:Ord:MDSv3


Als specialized service disposable supplies; iv drug therapy


Upper extremity addition, shoulder joint, multipositional locking, flexion, adjustable abduction friction control, for use with body powered or external powered system


Women who had a bilateral mastectomy or who have a history of a bilateral mastectomy or for whom there is evidence of a right and a left unilateral mastectomy


Rural Residence

biolink:PhysicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:PhysicalEssenceOrOccurrent


Transcendental Meditation(TM) in-residence course group each course


Medication action/side effects case management


Limited life expectancy of approximately one year


Computerized Assessment of Response Bias


Education about take home naloxone for opiate overdose intervention


Amphetamine type substance use disorder, severe


Mental and behavioral disorders due to use of other stimulants inclduing caffeine, residual and late-onset psychotic disorder


Mental and behavioral disorders due to multiple drug use and use of other psychoactive substances


Intentional non-opiate analgesic overdose


CATARACT, SUTURAL, WITH PUNCTATE AND CERULEAN OPACITIES


16-epivellosimine + acetyl-CoA = CoA + vinorine


Counselor - Addiction (Substance Use Disorder)


Addictive behavior

When an activity, substance, object, or behavior becomes a major focus of a person's life, excluding other activities, or has begun to harm the individual or others physically, mentally, or socially, it can be considered addictive behavior. A person can become addicted or compulsively engaged with anything.


otolaryngologic surgical result: quality of sleep improved


Electroencephalographic monitoring system, stationary


Attention-deficit/hyperactivity disorder, predominantly hyperactive impulsive presentation


belching after drinking carbonated beverages


insomnia

A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep.


gender identity disorder sexually attracted to females


Persistent disorder of initiating or maintaining sleep


organic circadian rhythm sleep disorder in conditions classified elsewhere


Epidural neurostimulator electrode procedure


conus medullaris

The conus medullaris is the terminal end of the spinal cord. It occurs near lumbar vertebral levels 1 (L1) and 2 (L2). After the spinal cord tapers out, the spinal nerves continue as dangling nerve roots called cauda equina. This terminal nerve root tail is referred to as the filum terminale. The upper end of the conus medullaris is usually not well defined.


implantation of cortical neurostimulator


Purkinje cell

The output neuron of the cerebellar cortex.


Sickle Cell Trait

An individual who is heterozygous for the mutation that causes sickle cell anemia.


Postural instability

A tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps.


Neurostimulation procedures of spinal cord tissue


spinal cord dorsal column

The wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception.


Deep brain electrical stimulation system


Generator, neurostimulator (implantable), high frequency, with rechargeable battery and charging system


Single-channel radiation counting system


dermatome

A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells.


GDNF

A glial cell line-derived neurotrophic factor that is encoded in the genome of human.


Ehlers-Danlos syndrome

The Ehlers–Danlos syndromes (EDS) are a clinically and genetically heterogeneous group of heritable connective tissue disorders (HCTDs) characterized by joint hypermobility, skin hyperextensibility, and tissue fragility.


connective tissue

Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.


Acute respiratory distress syndrome due to COVID-19


Underdosing and nonadministration of necessary drug, medicament or biological substance


Mental disorder caused by methamphetamine


C-reactive protein

A protein that is a translation product of the human CRP gene or a 1:1 ortholog thereof.


Pre-existing malnutrition-related diabetes mellitus


blood

A fluid that is composed of blood plasma and erythrocytes.


Practitioners Engaged in Applied Research and Learning Network


Pain Intensity Scale-Adolescent and Adult


sex determination, somatic-gonadal interaction

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism.


A sphingolipid Delta(4)-desaturase/C4-monooxygenase DES2 that is encoded in the genome of mouse.


A sphingolipid Delta(4)-desaturase DES1 that is encoded in the genome of mouse.


fear of prognosis

biolink:Behavior biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:ActivityAndBehavior biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Lekholm and Zarb classification

biolink:Procedure biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Hospital Organization and Administration

biolink:Activity biolink:NamedThing biolink:ActivityAndBehavior biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Substance abuse therapy group each 60 minutes


Spiritual nurse care consultation each 15 minutes


Dibenzoxazepine derivative antipsychotic agent, NOS


Transcranial electrical stimulation system, continuous-current


Restlessness

A state of unease is characterized by diffuse motor activity or motion, which is subject to limited control, nonproductive, or disorganized behavior.


A large neutral amino acids transporter small subunit 1 that is encoded in the genome of mouse.


Allodynia

Pain due to a stimulus that does not normally provoke pain.


Adverse event

Any unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure. Such events can be related to the intervention, dose, route of administration, patient, or caused by an interaction with another drug(s) or procedure(s).


Demyelination

Breakdown, or abnormal development, of a nerve fiber myelin sheath.


Infectious agent detection by nucleic acid (DNA or RNA); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]), amplified probe technique


ALCOHOL AND/OR DRUG SERVICES; METHADONE ADMINISTRATION AND/OR SERVICE (PROVISION OF THE DRUG BY A LICENSED PROGRAM)


Thrombolytic agent not administered because contraindicated


Posterior midline of lumbar area

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Structure of soft tissue of lumbar vertebral column


channelopathy-associated congenital insensitivity to pain, autosomal recessive

A syndrome characterized by indifference to pain despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and intellectual disability may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)


Virtual-display leg rehabilitation system


Assessment using patient satisfaction score


cellular tumor antigen p53

A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof.


hematopoietic stem cell proliferation

The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.


hereditary persistent fetal hemoglobin Hb-A


CD34-positive, CD38-negative hematopoietic stem cell

CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.


dentin sensitivity

Pain or discomfort caused by exposure of the dentin layer of tooth to thermal, tactile, or other stimuli.


baseline flow cytometry before treatment


A sodium- and chloride-dependent taurine transporter that is encoded in the genome of human.


COMT (catechol-O-methyltransferase) (eg, drug metabolism) gene analysis, c.472G>A (rs4680) variant


mast cell

A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.


mastocytosis

A clonal myeloproliferative neoplasm characterized by the proliferation and accumulation of neoplastic mast cells in one or multiple organs or organ systems. It is a heterogeneous group of neoplasms, ranging from cutaneous proliferations which may regress spontaneously, to aggressive neoplasms associated with organ failure and short survival.


eukaryotic initiation factor 4E binding

Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.


nerve growth factor processing

The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor.


BDNF

A brain-derived neurotrophic factor that is encoded in the genome of human.


parathyroid hormone-related protein

A protein that is a translation product of the human PTHLH gene or a 1:1 ortholog thereof.


transient receptor potential cation channel TRPV1

A transient receptor potential cation channel TRPV that is a translation product of the human TRPV1 gene or a 1:1 ortholog thereof.


parathyroid hormone receptor binding

Binding to a parathyroid hormone receptor.


Five Facet Mindfulness Questionnaire (FFMQ) describing score


obstetric ultrasound: multiple fetuses identification criteria


Merkel cell

A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber.


piezo channel protein

An ion channel protein that is a translation product of the human PIEZO1 or PIEZO2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.


leukemia

A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years.


CEPBA-Related Predisposition to Leukemia

An autosomal dominant condition caused by mutation(s) in the CEBPA gene, encoding CCAAT/enhancer-binding protein alpha. It is characterized by an increased risk of developing hematologic malignancies, primarily myeloid.


Adult patients 18 years of age or older with major depression or dysthymia who did not reach remission at twelve months as demonstrated by a twelve month (+/-60 days) phq-9 or phq-9m score of less than 5. either phq- 9 or phq-9m score was not assessed or is greater than or equal to 5


Impaired executive functioning

A disturbance of executive functioning, which is broadly defined as the set of abilities that allow for the planning, executing, monitoring, and self-correcting of goal-directed behavior while inhibiting task-irrelevant behavior. At least some degree of executive skill is needed to complete most cognitive tasks, and deficits in executive abilities are central to many clinical conditions, including fronto-temporal dementia.


Knee pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the knee.


Kinesiophobia

An excessive, irrational, and debilitating fear of carrying out a physical movement due to a feeling of vulnerability to painful injury or reinjury.


Vaso-Occlusive Crisis

An exacerbation of sickle cell disease.


capillary

Any of the smallest blood vessels connecting arterioles with venules.


Weight loss management individual each 15 minutes


Weight management individual each 15 minutes


serine/threonine-protein kinase mTOR

A protein that is a translation product of the human MTOR gene or a 1:1 ortholog thereof.


Ras-related GTP-binding protein A

A protein that is a translation product of the human RRAGA gene or a 1:1 ortholog thereof.


cud

A bolus of semi-degraded food regurgitated from the reticulorumen of a ruminant, produced during the physical digestive process of rumination.


Determination of outcome, unsatisfactory to patient


Psychosocial dysfunction due to chronic pain


Suicidal ideation

Frequent thoughts about or preoccupation with killing oneself.


Src substrate cortactin

A protein that is a translation product of the human CTTN gene or a 1:1 ortholog thereof.


casein kinase II subunit alpha

A protein that is a translation product of the human CSNK2A1 gene or a 1:1 ortholog thereof.


Lomitapide

A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.


Head and neck cancer metastatic

A carcinoma that arises from the head and neck and has spread from the original site of growth to another anatomic site.


orofacial cleft 1

Cleft lip with or without cleft palate mapped to chromosome 6p24.


tibial nerve

The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch of soleus. In the popliteal fossa the nerve gives off branches to gastrocnemius, popliteus, soleus and plantaris muscles, an articular branch to the knee joint, and a cutaneous branch that will become the sural nerve. The sural nerve is joined by fibres from the common peroneal nerve and runs down the calf to supply the lateral side of the foot. Below the soleus muscle the nerve lies close to the tibia and supplies the tibialis posterior, the flexor digitorum longus and the flexor hallucis longus. The nerve passes into the foot running posterior to the medial malleolus. Here it is bound down by the flexor retinaculum in company with the posterior tibial artery. [WP,unvetted].


transcription factor Sp4

A transcription factor Sp that is a translation product of the human SP4 gene or a 1:1 ortholog thereof.


Arthropathy due to type 2 diabetes mellitus


sodium-potassium-chloride cotransporter 1 protein


Sjogren syndrome

An autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain


RAM/MOR signaling pathway

An intracellular signaling pathway that regulates interphase polarized growth and cell separation at the end of cytokinesis through activation of the NDR1/2-related kinase.


retinal disorder

Any disease or disorder of the retina.


physical therapy precautions for range of motion of hip


HOOS JR (Hip disability and Osteoarthritis Outcome Score, Joint Replacement) questionnaire


Merkel nerve ending

Mechanoreceptors found in the skin and mucosa of vertebrates that provide touch information to the brain. The information they provide are those regarding pressure and texture. Each ending consists of a Merkel cell in close apposition with an enlarged nerve terminal.


taxis in response to touch stimulus

biolink:PhysiologicalProcess biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


regulator of G-protein signaling 12

A protein that is a translation product of the human RGS12 gene or a 1:1 ortholog thereof.


small GTPase mediated signal transduction

The series of molecular signals in which a small monomeric GTPase relays a signal.


dopamine uptake involved in synaptic transmission

The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.