LCE3A_HUMAN Late cornified envelope protein 3A (sprot)

A late cornified envelope protein 3A that is encoded in the genome of human.


LCE3B_HUMAN Late cornified envelope protein 3B (sprot)

A late cornified envelope protein 3B that is encoded in the genome of human.


LCE4A_HUMAN Late cornified envelope protein 4A (sprot)

A late cornified envelope protein 4A that is encoded in the genome of human.


LCE2A_HUMAN Late cornified envelope protein 2A (sprot)

A late cornified envelope protein 2A that is encoded in the genome of human.


LCE2C_HUMAN Late cornified envelope protein 2C (sprot)

A late cornified envelope protein 2C that is encoded in the genome of human.


LCE2D_HUMAN Late cornified envelope protein 2D (sprot)

A late cornified envelope protein 2D that is encoded in the genome of human.


CODA1_HUMAN Collagen alpha-1(XIII) chain (sprot)

A collagen alpha-1(XIII) chain that is encoded in the genome of human.


CP4AM_HUMAN Cytochrome P450 4A22 (sprot)

A cytochrome P450 4A22 that is encoded in the genome of human.


LCE5A_HUMAN Late cornified envelope protein 5A (sprot)

A late cornified envelope protein 5A that is encoded in the genome of human.


LPCT4_HUMAN Lysophospholipid acyltransferase LPCAT4 (sprot)

A lysophosphatidylcholine acyltransferase that is encoded in the genome of human.


MUC17_HUMAN Mucin-17 (sprot)

A mucin-17 that is encoded in the genome of human.


ACS2B_HUMAN Acyl-coenzyme A synthetase ACSM2B, mitochondrial (sprot)

An acyl-coenzyme A synthetase ACSM2B, mitochondrial that is encoded in the genome of human.


TRI68_HUMAN E3 ubiquitin-protein ligase TRIM68 (sprot)

An E3 ubiquitin-protein ligase TRIM68 that is encoded in the genome of human.


GLYAT_HUMAN Glycine N-acyltransferase (sprot)

A glycine N-acyltransferase that is encoded in the genome of human.


GPAT2_HUMAN Glycerol-3-phosphate acyltransferase 2, mitochondrial (sprot)

A glycerol-3-phosphate acyltransferase 2, mitochondrial that is encoded in the genome of human.


ACSM5_HUMAN Acyl-coenzyme A synthetase ACSM5, mitochondrial (sprot)

An acyl-coenzyme A synthetase ACSM5, mitochondrial that is encoded in the genome of human.


UD3A1_HUMAN UDP-glucuronosyltransferase 3A1 (sprot)

A UDP-glucuronosyltransferase 3A1 that is encoded in the genome of human.


ERAP2_HUMAN Endoplasmic reticulum aminopeptidase 2 (sprot)

An endoplasmic reticulum aminopeptidase 2 that is encoded in the genome of human.


MBOA5_HUMAN Lysophospholipid acyltransferase 5 (sprot)

A lysophospholipid acyltransferase 5 that is encoded in the genome of human.


PKN3_HUMAN Serine/threonine-protein kinase N3 (sprot)

A serine/threonine-protein kinase N3 that is encoded in the genome of human.


DCR1A_HUMAN DNA cross-link repair 1A protein (sprot)

A DNA cross-link repair 1A protein that is encoded in the genome of human.


CSPG4_HUMAN Chondroitin sulfate proteoglycan 4 (sprot)

A chondroitin sulfate proteoglycan 4 that is encoded in the genome of human.


EPGN_HUMAN Epigen (sprot)

An epigen that is encoded in the genome of human.


UD2A3_HUMAN UDP-glucuronosyltransferase 2A3 (sprot)

A UDP-glucuronosyltransferase 2A3 that is encoded in the genome of human.


GLB1L_HUMAN Beta-galactosidase-1-like protein (sprot)

A beta-galactosidase-1-like protein that is encoded in the genome of human.


KSR2_HUMAN Kinase suppressor of Ras 2 (sprot)

A kinase suppressor of Ras 2 that is encoded in the genome of human.


MUC6_HUMAN Mucin-6 (sprot)

A mucin-6 that is encoded in the genome of human.


RPTN_HUMAN Repetin (sprot)

A repetin that is encoded in the genome of human.


TPTE2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (sprot)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 that is encoded in the genome of human.


GBP6_HUMAN Guanylate-binding protein 6 (sprot)

A guanylate-binding protein 6 that is encoded in the genome of human.


MBOA1_HUMAN Lysophospholipid acyltransferase 1 (sprot)

A lysophospholipid acyltransferase 1 that is encoded in the genome of human.


GCNT7_HUMAN Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 (sprot)

A beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 that is encoded in the genome of human.


MBOA2_HUMAN Lysophospholipid acyltransferase 2 (sprot)

A lysophospholipid acyltransferase 2 that is encoded in the genome of human.


CHSS3_HUMAN Chondroitin sulfate synthase 3 (sprot)

A chondroitin sulfate synthase 3 that is encoded in the genome of human.


H32_HUMAN Histone H3.2 (sprot)

A histone H3.2 that is a translation product of any of the following genes in human: HIST2H3A/HIST2H3C/HIST2H3D.


UTS2B_HUMAN Urotensin-2B (sprot)

A urotensin-2B that is encoded in the genome of human.


carbohydrate sulfotransferase 9 isoform h2 (human)

A carbohydrate sulfotransferase 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7L1S5-2.


PCAT2_HUMAN Lysophosphatidylcholine acyltransferase 2 (sprot)

A lysophosphatidylcholine acyltransferase 2 that is encoded in the genome of human.


GRP2_HUMAN RAS guanyl-releasing protein 2 (sprot)

A RAS guanyl-releasing protein 2 that is encoded in the genome of human.


CHST3_HUMAN Carbohydrate sulfotransferase 3 (sprot)

A carbohydrate sulfotransferase 3 that is encoded in the genome of human.


ADM2_HUMAN Protein ADM2 (sprot)

A protein ADM2 that is encoded in the genome of human.


TRI46_HUMAN Tripartite motif-containing protein 46 (sprot)

A tripartite motif-containing protein 46 that is encoded in the genome of human.


MUC19_HUMAN Mucin-19 (sprot)

A mucin-19 that is encoded in the genome of human.


SETD3_HUMAN Actin-histidine N-methyltransferase (sprot)

An actin-histidine N-methyltransferase that is encoded in the genome of human.


LDHD_HUMAN Probable D-lactate dehydrogenase, mitochondrial (sprot)

A probable D-lactate dehydrogenase, mitochondrial that is encoded in the genome of human.


HUNIN_HUMAN Humanin (sprot)

A humanin that is encoded in the genome of human.


GLBL2_HUMAN Beta-galactosidase-1-like protein 2 (sprot)

A beta-galactosidase-1-like protein 2 that is encoded in the genome of human.


HSC20_HUMAN Iron-sulfur cluster co-chaperone protein HscB (sprot)

An iron-sulfur cluster co-chaperone protein HscB that is encoded in the genome of human.


TRI48_HUMAN E3 ubiquitin-protein ligase TRIM48 (sprot)

An E3 ubiquitin-protein ligase TRIM48 that is encoded in the genome of human.


GT252_HUMAN Procollagen galactosyltransferase 2 (sprot)

A procollagen galactosyltransferase 2 that is encoded in the genome of human.


PSYR_HUMAN Psychosine receptor (sprot)

A psychosine receptor that is encoded in the genome of human.


CHSS2_HUMAN Chondroitin sulfate synthase 2 (sprot)

A chondroitin sulfate synthase 2 that is encoded in the genome of human.


CORA1_HUMAN Collagen alpha-1(XXVII) chain (sprot)

A collagen alpha-1(XXVII) chain that is encoded in the genome of human.


H6ST3_HUMAN Heparan-sulfate 6-O-sulfotransferase 3 (sprot)

A heparan-sulfate 6-O-sulfotransferase 3 that is encoded in the genome of human.


GPC2_HUMAN Glypican-2 (sprot)

A glypican-2 that is encoded in the genome of human.


PLD6_HUMAN Mitochondrial cardiolipin hydrolase (sprot)

A phospholipase D6 that is encoded in the genome of human.


MUC15_HUMAN Mucin-15 (sprot)

A mucin-15 that is encoded in the genome of human.


CGAT2_HUMAN Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (sprot)

A chondroitin sulfate N-acetylgalactosaminyltransferase 2 that is encoded in the genome of human.


GBP7_HUMAN Guanylate-binding protein 7 (sprot)

A guanylate-binding protein 7 that is encoded in the genome of human.


GT251_HUMAN Procollagen galactosyltransferase 1 (sprot)

A procollagen galactosyltransferase 1 that is encoded in the genome of human.


GLBL3_HUMAN Beta-galactosidase-1-like protein 3 (sprot)

A beta-galactosidase-1-like protein 3 that is encoded in the genome of human.


SIA7C_HUMAN Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (sprot)

An alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 that is encoded in the genome of human.


CHSTD_HUMAN Carbohydrate sulfotransferase 13 (sprot)

A carbohydrate sulfotransferase 13 that is encoded in the genome of human.


PKR2_HUMAN Prokineticin receptor 2 (sprot)

A prokineticin receptor 2 that is encoded in the genome of human.


STEA2_HUMAN Metalloreductase STEAP2 (sprot)

A metalloreductase STEAP2 that is encoded in the genome of human.


COMA1_HUMAN Collagen alpha-1(XXII) chain (sprot)

A collagen alpha-1(XXII) chain that is encoded in the genome of human.


GP150_HUMAN Probable G-protein coupled receptor 150 (sprot)

A probable G-protein coupled receptor 150 that is encoded in the genome of human.


MUC7_HUMAN Mucin-7 (sprot)

A mucin-7 that is encoded in the genome of human.


PKR1_HUMAN Prokineticin receptor 1 (sprot)

A prokineticin receptor 1 that is encoded in the genome of human.


CGAT1_HUMAN Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (sprot)

A chondroitin sulfate N-acetylgalactosaminyltransferase 1 that is encoded in the genome of human.


GLYL2_HUMAN Glycine N-acyltransferase-like protein 2 (sprot)

A glycine N-acyltransferase-like protein 2 that is encoded in the genome of human.


PHIP_HUMAN PH-interacting protein (sprot)

A PH-interacting protein that is encoded in the genome of human.


sialidase-4 isoform h2 (human)

A sialidase-4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WWR8-2.


CNKR2_HUMAN Connector enhancer of kinase suppressor of ras 2 (sprot)

A connector enhancer of kinase suppressor of ras 2 that is encoded in the genome of human.


MUC16_HUMAN Mucin-16 (sprot)

A mucin-16 that is encoded in the genome of human.


CHC10_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (sprot)

A coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial that is encoded in the genome of human.


SIA8A_HUMAN Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (sprot)

An alpha-N-acetylneuraminide alpha-2,8-sialyltransferase that is encoded in the genome of human.


SIA8B_HUMAN Alpha-2,8-sialyltransferase 8B (sprot)

An alpha-2,8-sialyltransferase 8B that is encoded in the genome of human.


A CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase that is encoded in the genome of human.


SHC3_HUMAN SHC-transforming protein 3 (sprot)

An SHC-transforming protein 3 that is encoded in the genome of human.


LPIN2_HUMAN Phosphatidate phosphatase LPIN2 (sprot)

A phosphatidate phosphatase LPIN2 that is encoded in the genome of human.


P55G_HUMAN Phosphatidylinositol 3-kinase regulatory subunit gamma (sprot)

A phosphatidylinositol 3-kinase regulatory subunit gamma that is encoded in the genome of human.


LGAT1_HUMAN Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (sprot)

An acyl-CoA:lysophosphatidylglycerol acyltransferase 1 that is encoded in the genome of human.


FCGRB_HUMAN Putative high affinity immunoglobulin gamma Fc receptor IB (sprot)

A putative high affinity immunoglobulin gamma Fc receptor IB that is encoded in the genome of human.


SYN2_HUMAN Synapsin-2 (sprot)

A synapsin-2 that is encoded in the genome of human.


AT2A3_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (sprot)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 that is encoded in the genome of human.


CNKR1_HUMAN Connector enhancer of kinase suppressor of ras 1 (sprot)

A connector enhancer of kinase suppressor of ras 1 that is encoded in the genome of human.


GLYL1_HUMAN Glycine N-acyltransferase-like protein 1 (sprot)

A glycine N-acyltransferase-like protein 1 that is encoded in the genome of human.


TAAR8_HUMAN Trace amine-associated receptor 8 (sprot)

A trace amine-associated receptor 8 that is encoded in the genome of human.


MCHR2_HUMAN Melanin-concentrating hormone receptor 2 (sprot)

A melanin-concentrating hormone receptor 2 that is encoded in the genome of human.


MYL11_HUMAN Myosin regulatory light chain 11 (sprot)

A myosin regulatory light chain 11 that is encoded in the genome of human.


COQA1_HUMAN Collagen alpha-1(XXVI) chain (sprot)

A collagen alpha-1(XXVI) chain that is encoded in the genome of human.


TIP39_HUMAN Tuberoinfundibular peptide of 39 residues (sprot)

A tuberoinfundibular peptide of 39 residues that is encoded in the genome of human.


MSI2H_HUMAN RNA-binding protein Musashi homolog 2 (sprot)

An RNA-binding protein Musashi homolog 2 that is encoded in the genome of human.


MUCL1_HUMAN Mucin-like protein 1 (sprot)

A mucin-like protein 1 that is encoded in the genome of human.


ERLEC_HUMAN Endoplasmic reticulum lectin 1 (sprot)

An endoplasmic reticulum lectin 1 that is encoded in the genome of human.


DHTK1_HUMAN 2-oxoadipate dehydrogenase complex component E1 (sprot)

A 2-oxoadipate dehydrogenase complex component E1 that is encoded in the genome of human.


SC22A_HUMAN Vesicle-trafficking protein SEC22a (sprot)

A vesicle-trafficking protein SEC22a that is encoded in the genome of human.


SIAT2_HUMAN Beta-galactoside alpha-2,6-sialyltransferase 2 (sprot)

A beta-galactoside alpha-2,6-sialyltransferase 2 that is encoded in the genome of human.


H6ST2_HUMAN Heparan-sulfate 6-O-sulfotransferase 2 (sprot)

A heparan-sulfate 6-O-sulfotransferase 2 that is encoded in the genome of human.


COLA1_HUMAN Collagen alpha-1(XXI) chain (sprot)

A collagen alpha-1(XXI) chain that is encoded in the genome of human.


GBP4_HUMAN Guanylate-binding protein 4 (sprot)

A guanylate-binding protein 4 that is encoded in the genome of human.


UHRF2_HUMAN E3 ubiquitin-protein ligase UHRF2 (sprot)

An E3 ubiquitin-protein ligase UHRF2 that is encoded in the genome of human.


HS3S6_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 6 (sprot)

A heparan sulfate glucosamine 3-O-sulfotransferase 6 that is encoded in the genome of human.


TAAR6_HUMAN Trace amine-associated receptor 6 (sprot)

A trace amine-associated receptor 6 that is encoded in the genome of human.


TAAR9_HUMAN Trace amine-associated receptor 9 (sprot)

A trace amine-associated receptor 9 that is encoded in the genome of human.


TAAR1_HUMAN Trace amine-associated receptor 1 (sprot)

A trace amine-associated receptor 1 that is encoded in the genome of human.


SPR2F_HUMAN Small proline-rich protein 2F (sprot)

A small proline-rich protein 2F that is encoded in the genome of human.


MUC4_HUMAN Mucin-4 (sprot)

A mucin-4 that is encoded in the genome of human.


TI17A_HUMAN Mitochondrial import inner membrane translocase subunit Tim17-A (sprot)

A mitochondrial import inner membrane translocase subunit Tim17-A that is encoded in the genome of human.


GPR20_HUMAN G-protein coupled receptor 20 (sprot)

A G-protein coupled receptor 20 that is encoded in the genome of human.


MCHR1_HUMAN Melanin-concentrating hormone receptor 1 (sprot)

A melanin-concentrating hormone receptor 1 that is encoded in the genome of human.


COCA1_HUMAN Collagen alpha-1(XII) chain (sprot)

A collagen alpha-1(XII) chain that is encoded in the genome of human.


SNAG_HUMAN Gamma-soluble NSF attachment protein (sprot)

A gamma-soluble NSF attachment protein that is encoded in the genome of human.


TCPH_HUMAN T-complex protein 1 subunit eta (sprot)

A T-complex protein 1 subunit eta that is encoded in the genome of human.


OMD_HUMAN Osteomodulin (sprot)

An osteomodulin that is encoded in the genome of human.


LPIN3_HUMAN Phosphatidate phosphatase LPIN3 (sprot)

A phosphatidate phosphatase LPIN3 that is encoded in the genome of human.


SC22C_HUMAN Vesicle-trafficking protein SEC22c (sprot)

A vesicle-trafficking protein SEC22c that is encoded in the genome of human.


CHCH5_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 (sprot)

A coiled-coil-helix-coiled-coil-helix domain-containing protein 5 that is encoded in the genome of human.


MYL10_HUMAN Myosin regulatory light chain 10 (sprot)

A myosin regulatory light chain 10 that is encoded in the genome of human.


CHCH7_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 (sprot)

A coiled-coil-helix-coiled-coil-helix domain-containing protein 7 that is encoded in the genome of human.


SIA7E_HUMAN Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (sprot)

An alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 that is encoded in the genome of human.


ELOV1_HUMAN Elongation of very long chain fatty acids protein 1 (sprot)

An elongation of very long chain fatty acids protein 1 that is encoded in the genome of human.


ORNT2_HUMAN Mitochondrial ornithine transporter 2 (sprot)

A mitochondrial ornithine transporter 2 that is encoded in the genome of human.


GBRL3_HUMAN Gamma-aminobutyric acid receptor-associated protein-like 3 (sprot)

A gamma-aminobutyric acid receptor-associated protein-like 3 that is encoded in the genome of human.


UDB28_HUMAN UDP-glucuronosyltransferase 2B28 (sprot)

A UDP-glucuronosyltransferase 2B28 that is encoded in the genome of human.


LCE3D_HUMAN Late cornified envelope protein 3D (sprot)

A late cornified envelope protein 3D that is encoded in the genome of human.


SPR2G_HUMAN Small proline-rich protein 2G (sprot)

A small proline-rich protein 2G that is encoded in the genome of human.


TRI34_HUMAN E3 ubiquitin-protein ligase TRIM34 (sprot)

An E3 ubiquitin-protein ligase TRIM34 that is encoded in the genome of human.


NSD3_HUMAN Histone-lysine N-methyltransferase NSD3 (sprot)

A histone-lysine N-methyltransferase NSD3 that is encoded in the genome of human.


TRIM5_HUMAN Tripartite motif-containing protein 5 (sprot)

A tripartite motif-containing protein 5 that is encoded in the genome of human.


TRIM2_HUMAN Tripartite motif-containing protein 2 (sprot)

A tripartite motif-containing protein 2 that is encoded in the genome of human.


GRIP2_HUMAN Glutamate receptor-interacting protein 2 (sprot)

A glutamate receptor-interacting protein 2 that is encoded in the genome of human.


NPFF1_HUMAN Neuropeptide FF receptor 1 (sprot)

A neuropeptide FF receptor 1 that is encoded in the genome of human.


CHST5_HUMAN Carbohydrate sulfotransferase 5 (sprot)

A carbohydrate sulfotransferase 5 that is encoded in the genome of human.


IF5A2_HUMAN Eukaryotic translation initiation factor 5A-2 (sprot)

A eukaryotic translation initiation factor 5A-2 that is encoded in the genome of human.


CHST6_HUMAN Carbohydrate sulfotransferase 6 (sprot)

A carbohydrate sulfotransferase 6 that is encoded in the genome of human.


GBP3_HUMAN Guanylate-binding protein 3 (sprot)

A guanylate-binding protein 3 that is encoded in the genome of human.


SNAB_HUMAN Beta-soluble NSF attachment protein (sprot)

A beta-soluble NSF attachment protein that is encoded in the genome of human.


LPAR5_HUMAN Lysophosphatidic acid receptor 5 (sprot)

A lysophosphatidic acid receptor 5 that is encoded in the genome of human.


NDST4_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (sprot)

A bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 that is encoded in the genome of human.


MUC13_HUMAN Mucin-13 (sprot)

A mucin-13 that is encoded in the genome of human.


PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (sprot)

A tyrosine-protein phosphatase non-receptor type 23 that is encoded in the genome of human.


An alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase that is encoded in the genome of human.


SMYD3_HUMAN Histone-lysine N-methyltransferase SMYD3 (sprot)

A histone-lysine N-methyltransferase SMYD3 that is encoded in the genome of human.


DCR1B_HUMAN 5' exonuclease Apollo (sprot)

A 5' exonuclease Apollo that is encoded in the genome of human.


MTD2L_HUMAN Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (sprot)

A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial that is encoded in the genome of human.


UD17_HUMAN UDP-glucuronosyltransferase 1A7 (sprot)

A protein that is a translation product of the UGT1A7 gene in human.


UD18_HUMAN UDP-glucuronosyltransferase 1A8 (sprot)

A UDP-glucuronosyltransferase 1A8 that is encoded in the genome of human.


ELOV3_HUMAN Elongation of very long chain fatty acids protein 3 (sprot)

An elongation of very long chain fatty acids protein 3 that is encoded in the genome of human.


NMUR1_HUMAN Neuromedin-U receptor 1 (sprot)

A neuromedin-U receptor 1 that is encoded in the genome of human.


CP4FB_HUMAN Cytochrome P450 4F11 (sprot)

A cytochrome P450 4F11 that is encoded in the genome of human.


LPAR2_HUMAN Lysophosphatidic acid receptor 2 (sprot)

A lysophosphatidic acid receptor 2 that is encoded in the genome of human.


PROK2_HUMAN Prokineticin-2 (sprot)

A prokineticin-2 that is encoded in the genome of human.


TNR6C_HUMAN Trinucleotide repeat-containing gene 6C protein (sprot)

A trinucleotide repeat-containing gene 6C protein that is encoded in the genome of human.


PLPL8_HUMAN Calcium-independent phospholipase A2-gamma (sprot)

A calcium-independent phospholipase A2-gamma that is encoded in the genome of human.


DPOLM_HUMAN DNA-directed DNA/RNA polymerase mu (sprot)

A DNA-directed DNA/RNA polymerase mu that is encoded in the genome of human.


LT4R2_HUMAN Leukotriene B4 receptor 2 (sprot)

A leukotriene B4 receptor 2 that is encoded in the genome of human.


CHSTB_HUMAN Carbohydrate sulfotransferase 11 (sprot)

A carbohydrate sulfotransferase 11 that is encoded in the genome of human.


GPR84_HUMAN G-protein coupled receptor 84 (sprot)

A G-protein coupled receptor 84 that is encoded in the genome of human.


CP26B_HUMAN Cytochrome P450 26B1 (sprot)

A cytochrome P450 26B1 that is encoded in the genome of human.


CHSTC_HUMAN Carbohydrate sulfotransferase 12 (sprot)

A carbohydrate sulfotransferase 12 that is encoded in the genome of human.


COXM2_HUMAN COX assembly mitochondrial protein 2 homolog (sprot)

A COX assembly mitochondrial protein 2 homolog that is encoded in the genome of human.


PLCD_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (sprot)

A 1-acyl-sn-glycerol-3-phosphate acyltransferase delta that is encoded in the genome of human.


RGS18_HUMAN Regulator of G-protein signaling 18 (sprot)

A regulator of G-protein signaling 18 that is encoded in the genome of human.


GPR27_HUMAN Probable G-protein coupled receptor 27 (sprot)

A probable G-protein coupled receptor 27 that is encoded in the genome of human.


SIA7A_HUMAN Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (sprot)

An alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 that is encoded in the genome of human.


CISH_HUMAN Cytokine-inducible SH2-containing protein (sprot)

A cytokine-inducible SH2-containing protein that is encoded in the genome of human.


TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (sprot)

A tyrosyl-DNA phosphodiesterase 1 that is encoded in the genome of human.


COA4_HUMAN Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (sprot)

A coiled-coil-helix-coiled-coil-helix domain-containing protein 8 that is encoded in the genome of human.


TMOD3_HUMAN Tropomodulin-3 (sprot)

A tropomodulin-3 that is encoded in the genome of human.


GPR83_HUMAN G-protein coupled receptor 83 (sprot)

A G-protein coupled receptor 83 that is encoded in the genome of human.


ELOV5_HUMAN Elongation of very long chain fatty acids protein 5 (sprot)

An elongation of very long chain fatty acids protein 5 that is encoded in the genome of human.


FLRT1_HUMAN Leucine-rich repeat transmembrane protein FLRT1 (sprot)

A leucine-rich repeat transmembrane protein FLRT1 that is encoded in the genome of human.


GCNT4_HUMAN Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (sprot)

A beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 that is encoded in the genome of human.


TAAR3_HUMAN Putative trace amine-associated receptor 3 (sprot)

A putative trace amine-associated receptor 3 that is encoded in the genome of human.


TAAR2_HUMAN Trace amine-associated receptor 2 (sprot)

A trace amine-associated receptor 2 that is encoded in the genome of human.


COKA1_HUMAN Collagen alpha-1(XX) chain (sprot)

A collagen alpha-1(XX) chain that is encoded in the genome of human.


GBG13_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 (sprot)

A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 that is encoded in the genome of human.


SPRR3_HUMAN Small proline-rich protein 3 (sprot)

A small proline-rich protein 3 that is encoded in the genome of human.


XCL2_HUMAN Cytokine SCM-1 beta (sprot)

A cytokine SCM-1 beta that is encoded in the genome of human.


GBG12_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (sprot)

A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 that is encoded in the genome of human.


POLK_HUMAN DNA polymerase kappa (sprot)

A DNA polymerase kappa that is encoded in the genome of human.


LPAR3_HUMAN Lysophosphatidic acid receptor 3 (sprot)

A lysophosphatidic acid receptor 3 that is encoded in the genome of human.


TRI10_HUMAN Tripartite motif-containing protein 10 (sprot)

A tripartite motif-containing protein 10 that is encoded in the genome of human.


RGS17_HUMAN Regulator of G-protein signaling 17 (sprot)

A regulator of G-protein signaling 17 that is encoded in the genome of human.


DPOLL_HUMAN DNA polymerase lambda (sprot)

A DNA polymerase lambda that is encoded in the genome of human.


DAPK2_HUMAN Death-associated protein kinase 2 (sprot)

A death-associated protein kinase 2 that is encoded in the genome of human.


S2513_HUMAN Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (sprot)

An electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial that is encoded in the genome of human.


GBG8_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (sprot)

A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 that is encoded in the genome of human.


MUC12_HUMAN Mucin-12 (sprot)

A mucin-12 that is encoded in the genome of human.


SIAT9_HUMAN Lactosylceramide alpha-2,3-sialyltransferase (sprot)

A lactosylceramide alpha-2,3-sialyltransferase that is encoded in the genome of human.


CP8B1_HUMAN 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (sprot)

A cytochrome P450 8B1 that is encoded in the genome of human.


GP132_HUMAN Probable G-protein coupled receptor 132 (sprot)

A probable G-protein coupled receptor 132 that is encoded in the genome of human.


TRI35_HUMAN E3 ubiquitin-protein ligase TRIM35 (sprot)

An E3 ubiquitin-protein ligase TRIM35 that is encoded in the genome of human.


TNR6B_HUMAN Trinucleotide repeat-containing gene 6B protein (sprot)

A trinucleotide repeat-containing gene 6B protein that is encoded in the genome of human.


HS3S2_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 2 (sprot)

A heparan sulfate glucosamine 3-O-sulfotransferase 2 that is encoded in the genome of human.


ITM2B_HUMAN Integral membrane protein 2B (sprot)

An integral membrane protein 2B that is encoded in the genome of human.


MAN1_HUMAN Inner nuclear membrane protein Man1 (sprot)

An inner nuclear membrane protein Man1 that is encoded in the genome of human.


GRIP1_HUMAN Glutamate receptor-interacting protein 1 (sprot)

A glutamate receptor-interacting protein 1 that is encoded in the genome of human.


CHST2_HUMAN Carbohydrate sulfotransferase 2 (sprot)

A carbohydrate sulfotransferase 2 that is encoded in the genome of human.


TRI17_HUMAN E3 ubiquitin-protein ligase TRIM17 (sprot)

An E3 ubiquitin-protein ligase TRIM17 that is encoded in the genome of human.


NEDD8 ultimate buster 1 isoform h1 (human)

A NEDD8 ultimate buster 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5A7-1.


TIM8B_HUMAN Mitochondrial import inner membrane translocase subunit Tim8 B (sprot)

A mitochondrial import inner membrane translocase subunit Tim8 B that is encoded in the genome of human.


TIM13_HUMAN Mitochondrial import inner membrane translocase subunit Tim13 (sprot)

A mitochondrial import inner membrane translocase subunit Tim13 that is encoded in the genome of human.


NPFF2_HUMAN Neuropeptide FF receptor 2 (sprot)

A neuropeptide FF receptor 2 that is encoded in the genome of human.


GPR45_HUMAN Probable G-protein coupled receptor 45 (sprot)

A probable G-protein coupled receptor 45 that is encoded in the genome of human.


ORNT1_HUMAN Mitochondrial ornithine transporter 1 (sprot)

A mitochondrial ornithine transporter 1 that is encoded in the genome of human.


GPC6_HUMAN Glypican-6 (sprot)

A glypican-6 that is encoded in the genome of human.


HS3S4_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 4 (sprot)

A heparan sulfate glucosamine 3-O-sulfotransferase 4 that is encoded in the genome of human.


HS3SB_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (sprot)

A heparan sulfate glucosamine 3-O-sulfotransferase 3B1 that is encoded in the genome of human.


HS3SA_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 (sprot)

A heparan sulfate glucosamine 3-O-sulfotransferase 3A1 that is encoded in the genome of human.


CHCH2_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (sprot)

A coiled-coil-helix-coiled-coil-helix domain-containing protein 2 that is encoded in the genome of human.


sestrin-1 isoform T2 (human)

A sestrin-1 isoform 1 that is encoded in the genome of human.


sestrin-1 isoform hT3 (human)

A sestrin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6P5-3.


Hexanoate

A short-chain fatty acid anion that is the conjugate base of hexanoic acid (also known as caproic acid).


Elaidic Acid

A 9-octadecenoic acid and the trans-isomer of oleic acid.


The 13,14-dihydro derivative of 15-oxo-prostaglandin E2.


15-dehydro-prostaglandin D2

The 15-dehydro derivative of prostaglandin D2.


Valerate

A short-chain fatty acid anion that is the conjugate base of valeric acid; present in ester form as component of many steroid-based pharmaceuticals.


3-Methyl-2-oxobutanoic acid

A 2-oxo monocarboxylic acid that is the 2-oxo derivative of isovaleric acid.


A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.


N-acetylneuraminate

A ketoaldonate that is the conjugate base of N-acetylneuraminic acid, obtained by deprotonation of the carboxy group.


An organic heterotetracyclic compound obtained by intramolecular formation of a C-C bond between positions 8 and 5' of 2'-deoxyadenosine.


Pentadecanoic acid

A straight-chain saturated fatty acid containing fifteen-carbon atoms.


A HETE that consists of arachidonic acid bearing an additional hydroxy substituent at position 17.


A HETE that consists of arachidonic acid bearing an additional hydroxy substituent at position 16.


A resolvin that is docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid which is substituted by hydroxy groups at the 7 and 17 positions as well as an oxo group at the 8-position (the 7S,17S-stereoisomer).


A resolvin that is docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid which is substituted by hydroxy groups at the 7 and 8 positions as well as an oxo group at the 17-position (the 7S,8R-stereoisomer).


A beta-D-glucosiduronate that is the conjugate base of acetaminophen O-beta-D-glucosiduronic acid, obtained by deprotonation of the carboxy group.


A prostaglandin Falpha obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin F2alpha.


Adrenic acid

The all-cis-isomer of a C22 polyunsaturated fatty acid having four double bonds in the 7-, 10-, 13- and 16-positions. One of the most abundant fatty acids in the early human brain.


6-trans-12-epi-Leukotriene B4

A leukotriene that is the 6-trans,12S-isomer of leukotriene B4.


resolvin T1

A docosanoid that is (8E,10Z,14E,16Z,18E)-docosapentaenoic acid carrying three hydroxy substituents at positions 7, 13 and 20.


resolvin T2

A docosanoid that is (8Z,10E,14E,16Z,19Z)-docosapentaenoic acid carrying three hydroxy substituents at positions 7, 12 and 13.


resolvin T3

A docosanoid that is (9E,11E,14E,16Z,19Z)-docosapentaenoic acid carrying three hydroxy substituents at positions 7, 8 and 13.


resolvin T4

A docosanoid that is (8E,10Z,14E,16Z,19Z)-docosapentaenoic acid carrying two hydroxy substituents at positions 7 and 13.


A dihydroxydocosahexaenoic acid that is (4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at the 14S- and 21R-positions.


A dihydroxydocosahexaenoic acid that is (4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at the 14S- and 21S-positions.


A dihydroxydocosahexaenoic acid that is (4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at the 14R- and 21R-positions.


A dihydroxydocosahexaenoic acid that is (4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at the 14R- and 21S-positions.


11,14,17-Eicosatrienoic acid

An icosatrienoic acid having three cis- double bonds at positions 11, 14 and 17.


A hydroxydocosapentaenoic acid that is (4Z,7Z,10Z,13Z,15E)-docosapentaenoic acid in which the hydroxy group is located at the 17S-position. The 17S-oxygenated product of omega-6-DPA which possesses anti-inflammatory activity.


The 10(S),17(S)-dihydroxy product of omega 6-DPA which has anti-inflammatory activity


An inositol phosphate oxoanion obtained by deprotonation of all but one of the phosphate and diphosphate OH groups of 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


An inositol phosphate oxoanion obtained by deprotonation of the phosphate and diphosphate OH groups of 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate. It is the major microspecies at pH 7.3.


2-thiouridine 5'-phosphate(1-) residue

An organic anionic group obtained by deprotonation of the phosphate OH group of 2-thiouridine 5'-phosphate residue; major species at pH 7.3.


An anionic ganglioside that is the conjugate base of alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N acetylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide arising from deprotonation of the neuraminosyl carboxy groups; major species at pH 7.3.


N-Choloylglycine

A cholanic acid conjugate anion that is the conjugate base of glycocholic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


Deoxycytidine-diphosphate

A 2'-deoxyribonucleoside 5'-diphosphate obtained by deprotonation of the diphosphate OH groups of 2'-deoxycytidine 5'-diphosphate (dCDP).


A 2-oxo monocarboxylic acid anion that is the conjugate base of 3-methyl-2-oxovaleric acid, arising from deprotonation of the carboxy group; major species at pH 7.3.


dADP trianion

A 2'-deoxyribonucleoside 5'-diphosphate obtained by deprotonation of the diphosphate OH groups of 2'-deoxyadenosine 5'-diphosphate (dADP); major species at pH 7.3.


Taurochenodeoxycholate anion

An organosulfonate oxoanion that is the conjugate base of taurochenodeoxycholic acid arising from deprotonation of the sulfonate OH group; major species at pH 7.3.


An organosulfonate oxoanion that is the conjugate base of taurocholic acid.


metabolite of salicylate


Thymidine-diphosphate

An organophosphate oxoanion arising from deprotonation of the diphosphate OH groups of thymidine 5'-diphosphate; major species at pH 7.3.


N-glycoloyl-D-glucosamine

An N-glycoloylglucosamine of D configuration.


An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of ganglioside GQ1b; major species at pH 7.3.


An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of ganglioside GT1a; major species at pH 7.3.


An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of ganglioside GT1b; major species at pH 7.3.


An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-beta-Glc-(1<->1')-Cer; major species at pH 7.3.


Deoxyguanosine diphosphate

A 2'-deoxyribonucleoside 5'-diphosphate obtained by deprotonation of the diphosphate OH groups of dGDP.


A 17beta-hydroxy steroid that is testosterone that contains an additional double bond between positions 6 and 7.


A Glu-Cys-Gly tripeptide derivative of glutathione containing a 2-hydroxyethyl substituent on the S of the Cys residue.


N-hydroxy-4-aminobiphenyl O-glucuronide

A glucosiduronic acid that is the O-glucuronide of N-hydroxy-4-aminobiphenyl.


A glutathione derivative in which the hydrogen of the side-chain thiol function of glutathione is substituted by a 7-hydroxy-7,8-dihydrobenzo[pqr]tetraphen-8-yl group.


hepoxilin B3

A hepoxilin having (5Z,9E,14Z) double bond stereochemistry, a 10-hydroxy substituent and an (11S,12S)-epoxy group.


Troxilin B3

A trioxilin having (all-cis 5,8,14) double bond configuration; and 10-, (11S)- and (12R)-hydroxy substituents.


Glycochenodeoxycholate (1-)

A N-acylglycinate that is the conjugate base of glycochenodeoxycholic acid.


An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of ganglioside GP1c; major species at pH 7.3.


An N-acetyl-beta-D-glycosaminyl glycopeptide consisting of an N-acetyl-beta-D-glycosaminyl-(1->4)-N-acetylmuramoyl moiety attached to the amino terminus of the pentapeptide L-Ala-gamma-D-Glu-N(6)-(beta-D-Asp)-L-Lys-D-Ala-D-Ala via an amide linkage.


A myo-inositol tetrakisphosphate that consists of myo-inositol having the four phospho groups located at positions 1, 4, 5 and 6 as well as a diphospho group at position 3.


A linear heptasaccharide glycosyl group consisting of two N-acetylgalactosamine residues (one of which is sulfated at the 6-position), two glucuronic acid residues and two galactosyl residues linked to a xylosyl residue at the reducing end.


A linear heptasaccharide glycosyl group consisting of two N-acetylgalactosamine residues (one of which is sulfated at the 4-position), two glucuronic acid residues and two galactosyl residues linked to a xylosyl residue at the reducing end.


A linear heptasaccharide glycosyl group consisting of two N-acetylgalactosamine residues (one of which is disulfated at the 4-and 6-positions), two glucuronic acid residues and two galactosyl residues linked to a xylosyl residue at the reducing end.


A HETE that consists of arachidonic acid bearing a hydroxy substituent at position 18.


Nicotine glucuronide

An N-glycosylpyridine that is the N-alpha-D-glucosiduronyl derivative of (S)-nicotine.


6-trans-Leukotriene B4

A leukotriene that is the 6-trans-isomer of leukotriene B4.


epi-Lipoxin A4

A C20 hydroxy fatty acid having (5S)-, (6S)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.


epi-Lipoxin B4

A C20 hydroxy fatty acid having (5S)-, (14R)- and (15R)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds.


Phenyl beta-D-glucopyranosiduronic acid

A beta-D-glucosiduronic acid that is the glucuronide conjugate of phenol.


lipoxin B4

A C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds.


N-hydroxydebrisoquine O-glucuronide

A glucosiduronic acid that is the O-beta-D-glucuronide conjugate of N-hydroxydebrisoquine.


Retinol oleate

A fatty acid ester formed between oleic acid and all-trans-retinol.


All-trans-retinyl stearate

A fatty acid ester formed between stearic acid and all-trans-retinol.


Retinyl linoleate

A fatty acid ester formed between linoleic acid and all-trans-retinol.


Aflatoxin B1 endo-cysteinyl-conjugate

A metabolite of aflatoxin B1


Aflatoxin B1 endo-cysteinylglycine conjugate

A metabolite of aflatoxin B1


Aflatoxin B1 endo-N-acetylcysteine conjugate

A metabolite of aflatoxin B1


Aflatoxin B1 endo glutathione conjugate

A metabolite of aflatoxin B1


Aflatoxin B1 exo-cysteinyl-conjugate

A metabolite of aflatoxin B1


Aflatoxin B1 exo-cysteinylglycine conjugate

A metabolite of aflatoxin B1


Aflatoxin B1 exo-N-acetylcysteine conjugate

A metabolite of aflatoxin B1


Aflatoxin B1 exo glutathione conjugate

A metabolite of aflatoxin B1


An L-tyrosine derivative that is L-DOPA in which the hydrogen at position 2 on the phenyl ring is replaced by a cysteinyl group. Found in the urine of patients with melanoma.


An L-tyrosine derivative that is L-DOPA in which the hydrogens at positions 2 and 5 on the phenyl ring are replaced by cysteinyl groups. Found in the urine of patients with melanoma.


A member of the class of benzothiazines that is 2H-1,4-benzothiazine-3-carboxylic acid bearing additional hydroxy and 2-amino-2-carboxyethyl substituents at positions 5 and 7 respectively.


A member of the class of benzothiazoles bearing hydroxy and 2-amino-2-carboxyethyl substituents at positions 4 and 6 respectively.


A member of the class of benzothiazines that is 3,4-dihydro-2H-1,4-benzothiazin-3-one bearing additional hydroxy and 2-amino-2-carboxyethyl substituents at positions 5 and 7 respectively.


cytoplasmic vesicle membrane

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The lipid bilayer surrounding a cytoplasmic vesicle.


lysosomal lumen

The volume enclosed within the lysosomal membrane.


mitochondrial intermembrane space

The region between the inner and outer lipid bilayers of the mitochondrial envelope.


endosome lumen

The volume enclosed by the membrane of an endosome.


secretory granule membrane

The lipid bilayer surrounding a secretory granule.


phagocytic vesicle lumen

The volume enclosed by the membrane of a phagocytic vesicle.


clathrin-coated endocytic vesicle

A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.


photoreceptor disc membrane

Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.


platelet dense tubular network membrane

The lipid bilayer surrounding the platelet dense tubular network.


clathrin-coated endocytic vesicle membrane

The lipid bilayer surrounding a clathrin-coated endocytic vesicle.


endolysosome lumen

The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.


clathrin-sculpted monoamine transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle.


melanosome membrane

The lipid bilayer surrounding a melanosome.


multivesicular body lumen

The volume enclosed by the outermost membrane of a multivesicular body.


clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle.


ER to Golgi transport vesicle membrane

The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.


G-protein activated inward rectifier potassium channel activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.


sphingolipid activator protein activity

Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.


ATP-dependent activity, acting on RNA

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.


Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.


RNA ligase (ATP) activity

Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m).


Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.


isocitrate dehydrogenase (NAD+) activity

Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.


triphosphoric monoester hydrolase activity

Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.


NADH dehydrogenase (ubiquinone) activity

Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out).


3'-5' exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.


Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine.


Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.


cytochrome-b5 reductase activity, acting on NAD(P)H

Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).


structural constituent of nuclear pore

The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.


deoxynucleoside kinase activity

Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate.


dihydroorotate dehydrogenase activity

Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.


[pyruvate dehydrogenase (lipoamide)] phosphatase activity

Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate.


L-amino-acid oxidase activity

Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.


serine C-palmitoyltransferase activity

Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA.


methylmalonyl-CoA mutase activity

Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA.


alpha-galactosidase activity

Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.


Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine.


squalene monooxygenase activity

Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+.


beta-glucuronidase activity

Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.


iduronate-2-sulfatase activity

Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.


Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.


Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans.


acetyl-CoA C-acyltransferase activity

Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.


Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+.


CoA-ligase activity

Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.


dioxygenase activity

Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products.


vitamin-K-epoxide reductase (warfarin-sensitive) activity

Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues.


ryanodine-sensitive calcium-release channel activity

Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration and is sensitive to the plant alkaloid ryanodine.


ABC-type peptide antigen transporter activity

Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate.


membrane insertase activity

Binds transmembrane domain-containing proteins and mediates their integration into a membrane.


succinate dehydrogenase (ubiquinone) activity

Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol.


succinate-CoA ligase (GDP-forming) activity

Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.


oxaloacetate decarboxylase activity

Catalysis of the reaction: oxaloacetate = pyruvate + CO2.


citrate (Si)-synthase activity

Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.


succinate-CoA ligase (ADP-forming) activity

Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate.


malate dehydrogenase (decarboxylating) (NAD+) activity

Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.


NAD(P)+ transhydrogenase activity

Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.


oxoglutarate dehydrogenase (NAD+) activity

Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH.


dihydrolipoyl dehydrogenase activity

Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.


pyruvate decarboxylase activity

Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.


tRNA-specific ribonuclease activity

Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.


channel activity

Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.


Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.


trimethyllysine dioxygenase activity

Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate.


oxygen-dependent protoporphyrinogen oxidase activity

Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX.


ferrochelatase activity

Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX.


tRNA-guanosine(34) queuine transglycosylase activity

Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol.


monoatomic anion transmembrane transporter activity

Enables the transfer of a negatively charged ion from one side of a membrane to the other.


cytochrome-c oxidase activity

Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.


calcium ion transmembrane transporter activity

Enables the transfer of calcium (Ca) ions from one side of a membrane to the other.


histone H3K27 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein.


succinate-semialdehyde dehydrogenase (NAD+) activity

Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+.


acyl-CoA oxidase activity

Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.


Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.


glycine dehydrogenase (decarboxylating) activity

Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.


glucuronosyltransferase activity

Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.


Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.


ribonuclease P activity

Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.


Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.


Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen.


long-chain fatty acid-CoA ligase activity

Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.


tRNA-specific adenosine deaminase activity

Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule.


Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.


double-stranded RNA adenosine deaminase activity

Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.


Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA.


Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.


propionyl-CoA carboxylase activity

Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.


glycine amidinotransferase activity

Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate.


mannose binding

Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.


Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate.


histone demethylase activity

Catalysis of the removal of a methyl group from a histone.


L-threonine 3-dehydrogenase activity

Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + CO2 + NADH.


pristanoyl-CoA oxidase activity

Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide.


lipoate synthase activity

Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.


trans-2-enoyl-CoA reductase (NADPH) activity

Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+.


NADPHX epimerase activity

Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX.


mannosyltransferase activity

Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH.


UDP-xylosyltransferase activity

Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule.


proton-transporting ATP synthase activity, rotational mechanism

Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out).


catalase activity

Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.


glutaminase activity

Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.


glutamate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.


(S)-2-hydroxy-acid oxidase activity

Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide.


proline dehydrogenase activity

Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.


Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.


oxidative DNA demethylase activity

Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2.


Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H+.


cardiolipin hydrolase activity

Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA).


acylglycerol kinase activity

Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.


Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.


Catalysis of the reaction: H2O + phosphoethanolamine = acetaldehyde + NH4 + phosphate.


Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline.


UDP-glucuronic acid transmembrane transporter activity

Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate.


sulfite oxidase activity

Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate.


Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone.


sulfur dioxygenase activity

Catalysis of the reaction: sulfur + O2 + H2O = sulfite.


L-cysteine transaminase activity

Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.


adenine transmembrane transporter activity

Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other.


Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide.


steryl-sulfatase activity

Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.


cerebroside-sulfatase activity

Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate.


heme oxygenase (decyclizing) activity

Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase].


sterol esterase activity

Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid.


steroid delta-isomerase activity

Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid.


Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+.


11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity

Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+.


Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.


Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O.


sarcosine dehydrogenase activity

Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.


oxidoreductase activity, acting on NAD(P)H

Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


RNA transmembrane transporter activity

Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.


3-hydroxyacyl-CoA dehydratase activity

Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O.


dopamine beta-monooxygenase activity

Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O.


Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + an N-acyl-L-homoserine.


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.


Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.


Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.


IDP phosphatase activity

Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate.


dIDP phosphatase activity

Catalysis of the reaction: dIDP + H2O = dIMP + H+ + phosphate.


antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).


D-amino-acid oxidase activity

Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.


glyoxylate oxidase activity

Catalysis of the reaction: glyoxylate + H2O + O2 = H2O2 + H+ + oxalate.


ABC-type oligopeptide transporter activity

Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in).


carbon-carbon lyase activity

Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


phytanoyl-CoA dioxygenase activity

Catalysis of the reaction: 2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate.


Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.


D-aspartate oxidase activity

Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide.


Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate.


glucan 1,3-alpha-glucosidase activity

Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans.


A-type (transient outward) potassium channel activity

Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential.


Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.


acyl-CoA dehydrogenase activity

Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+.


Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine.


Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine.


Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine.


dimethylglycine dehydrogenase activity

Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein.


Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.


Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.


ornithine carbamoyltransferase activity

Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.


2-aminoadipate transaminase activity

Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate.


glutaryl-CoA dehydrogenase activity

3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].


saccharopine dehydrogenase (NADP+, L-lysine-forming) activity

Catalysis of the reaction: L-saccharopine + H2O + NADP+ = 2-oxoglutarate + L-lysine + H+ + NADPH.


saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity

Catalysis of the reaction: L-saccharopine + H2O + NAD+ = L-glutamate + allysine + H+ + NADH.


Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.


isovaleryl-CoA dehydrogenase activity

Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].


CoA-transferase activity

Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).


methylglutaconyl-CoA hydratase activity

Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O.


Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+.


second spliceosomal transesterification activity

Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.


oxidative RNA demethylase activity

Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.


3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity

Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+.


intramolecular oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears.


4-aminobutyrate transaminase activity

Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).


Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate.


calcium-dependent protein kinase activity

Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP.


Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan.


Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).


alpha-L-fucosidase activity

Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose.


metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process.


phospholipid metabolic process

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.


regulation of canonical NF-kappaB signal transduction

Any process that modulates the canonical NF-kappaB signaling cascade.


pyruvate metabolic process

The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.


Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains.


glutathione catabolic process

The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.


melanin biosynthetic process

The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.


L-phenylalanine metabolic process

The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.


glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.


xenobiotic catabolic process

The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


cardiac conduction

Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.


L-serine biosynthetic process

The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.


proline catabolic process

The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.


The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.


triglyceride biosynthetic process

The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.


dolichol-linked oligosaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P.


fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.


fructose biosynthetic process

The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose.


lactose synthase activity

Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose.


pentose-phosphate shunt

The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate).


5-phosphoribose 1-diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.


glucuronate catabolic process to xylulose 5-phosphate

The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate.


thyroid hormone generation

The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.


keratan sulfate biosynthetic process

The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.


oligosaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.


vitamin B6 metabolic process

The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.


tryptophan catabolic process

The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.


vitamin K metabolic process

The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.


pyruvate dehydrogenase (NAD+) activity

Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH.


glycosaminoglycan metabolic process

The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.


carboxylic acid transport

The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).


protein O-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.


coenzyme A biosynthetic process

The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.


creatine metabolic process

The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.


response to progesterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.


bile acid biosynthetic process

The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.


carnitine biosynthetic process

The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.


thyroid hormone metabolic process

The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.


lipid digestion

The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.


branched-chain amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.


mitochondrial electron transport, NADH to ubiquinone

The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.


mitochondrial electron transport, ubiquinol to cytochrome c

The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.


selenium compound metabolic process

The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.


phosphatidic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.


glyoxylate metabolic process

The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.


tRNA splicing, via endonucleolytic cleavage and ligation

Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.


histidine catabolic process

The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.


tyrosine catabolic process

The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.


heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan.


tRNA 5'-leader removal

Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.


ketone body biosynthetic process

The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.


phagosome acidification

Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion.


deoxyribonucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


rRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an rRNA molecule.


ketone body catabolic process

The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.


sodium-independent organic anion transport

The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


peptidyl-lysine modification to peptidyl-hypusine

The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine.


linoleic acid metabolic process

The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.


arachidonic acid metabolic process

The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.


fatty acid alpha-oxidation

A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.


short-chain fatty acid catabolic process

The chemical reactions and pathways resulting in the breakdown of a fatty acid with an aliphatic tail of less than 6 carbons.


androgen biosynthetic process

The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.


mitochondrial calcium ion transmembrane transport

The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.


gamma-aminobutyric acid catabolic process

The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.


urea cycle

The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.


glycerol biosynthetic process

The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


histamine biosynthetic process

The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.


gamma-aminobutyric acid biosynthetic process

The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.


L-methionine salvage from methylthioadenosine

The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.


prostanoid metabolic process

The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure.


Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains.


Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains.


cardiolipin acyl-chain remodeling

Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids.


Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains.


Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains.


3'-phosphoadenosine 5'-phosphosulfate metabolic process

The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.


cellular glucuronidation

The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor.


glutathione derivative biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione derivative.


nucleobase-containing small molecule metabolic process

The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.


transsulfuration

The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.


sulfide oxidation, using sulfide:quinone oxidoreductase

A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase.


L-cysteine catabolic process

The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid.


mitochondrial electron transport, cytochrome c to oxygen

The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV.


proton motive force-driven mitochondrial ATP synthesis

The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.


preassembly of GPI anchor in ER membrane

The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane.


xylulose biosynthetic process

The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose.


UDP-glucuronate biosynthetic process

The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate.


polysaccharide digestion

The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism.


hexose transmembrane transport

The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule.


estrogen biosynthetic process

The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.


mineralocorticoid biosynthetic process

The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.


thiamine-containing compound metabolic process

The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it.


riboflavin metabolic process

The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).


NAD metabolic process

The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.


NAD biosynthesis via nicotinamide riboside salvage pathway

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside.


pantothenate metabolic process

The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.


keratan sulfate catabolic process

The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.


alpha-linolenic acid metabolic process

The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.


catecholamine biosynthetic process

The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


indolalkylamine biosynthetic process

The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group.


hepoxilin metabolic process

The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology.


lipoxin biosynthetic process

The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signaling molecule that has four conjugated double bonds and is derived from arachidonic acid.


zinc ion import into Golgi lumen

The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen.


polyamine biosynthetic process

The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups.


L-alpha-amino acid transmembrane transport

The directed movement of L-alpha-amino acid across a membrane.


tRNA aminoacylation for protein translation

The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.


serotonin catabolic process

The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.


NADPH regeneration

A metabolic process that generates a pool of NADPH by the reduction of NADP+.


fatty acid beta-oxidation using acyl-CoA oxidase

A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).


pyrimidine nucleoside biosynthetic process

The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


nucleobase-containing small molecule interconversion

The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.


mitochondrial tRNA methylation

The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule.


rRNA methylation

The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.


choline catabolic process

The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.


glucosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.


galactose catabolic process

The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.


ethanol oxidation

An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate.


lysine catabolic process

The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.


pyrimidine nucleoside catabolic process

The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


purine-containing compound salvage

Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis.


purine nucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


L-threonine catabolic process to glycine

The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine.


nucleobase-containing small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.


aspartate family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.


pyruvate family amino acid metabolic process

The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine.


glutamine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.


intestinal hexose absorption

Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine.


O-glycan processing

The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure.


3'-5' DNA helicase activity

Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.


DNA helicase activity

Unwinding of a DNA helix, driven by ATP hydrolysis.


5'-3' DNA helicase activity

Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis.


3-keto sterol reductase activity

Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+.


delta24-sterol reductase activity

Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol.


C-4 methylsterol oxidase activity

Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O.


lanosterol synthase activity

Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.


sterol 14-demethylase activity

Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase].


delta14-sterol reductase activity

Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol.


hydrolase activity, hydrolyzing O-glycosyl compounds

Catalysis of the hydrolysis of any O-glycosyl bond.


beta-mannosidase activity

Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.


oxidoreductase activity, acting on the CH-CH group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


carboxylic acid transmembrane transporter activity

Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).