The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.


protein localization to cell junction

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A process in which a protein is transported to, or maintained in, a location within a cell junction.


regulation of cell-substrate junction organization

Any process that modulates the frequency, rate or extent of cell-substrate junction organization.


negative regulation of establishment of protein localization

Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization.


positive regulation of establishment of protein localization

Any process that activates or increases the frequency, rate or extent of establishment of protein localization.


membrane repolarization during cardiac muscle cell action potential

The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


phospholipase binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to a phospholipase.


negative regulation of protein localization

Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization.


perisynaptic space

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The extracellular region immediately adjacent to to a synapse.


cellular bud scar

Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age.


protein-containing complex organization

Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.


rod bipolar cell (sensu Mus)

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells.  These neurons have axons that arborize and synapse to targets in inner plexiform layers 4 and 5 and depolarize in response to light.


TPBG_MOUSE Trophoblast glycoprotein (sprot)

A trophoblast glycoprotein that is encoded in the genome of mouse.


CP110_MOUSE Centriolar coiled-coil protein of 110 kDa (sprot)

A centriolar coiled-coil protein of 110 kDa that is encoded in the genome of mouse.


CANB2_MOUSE Calcineurin subunit B type 2 (sprot)

A calcineurin subunit B type 2 that is encoded in the genome of mouse.


E9Q8Q6_MOUSE Coiled-coil domain containing 141 (trembl)


swimming behavior

The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.


optomotor response

Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish.


amyloid-beta formation

The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP).


regulation of endopeptidase activity

Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


cellular response to glucocorticoid stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.


TEAD4_HUMAN Transcriptional enhancer factor TEF-3 (sprot)

A transcriptional enhancer factor TEF-3 that is encoded in the genome of human.


TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (sprot)

A transcriptional enhancer factor TEF-4 that is encoded in the genome of human.


TEAD3_HUMAN Transcriptional enhancer factor TEF-5 (sprot)

A transcriptional enhancer factor TEF-5 that is encoded in the genome of human.


TEAD1_HUMAN Transcriptional enhancer factor TEF-1 (sprot)

A transcriptional enhancer factor TEF-1 that is encoded in the genome of human.


ADA complex

A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex.


lens placode formation

The initial developmental process that will lead to the formation of an eye.


regulation of JNK cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.


olfactory placode formation

The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.


forebrain anterior/posterior pattern specification

The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain.


embryonic eye morphogenesis

The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.


WNT5A_HUMAN Protein Wnt-5a (sprot)

A protein Wnt-5a that is encoded in the genome of human.


WNT3A_HUMAN Protein Wnt-3a (sprot)

A protein Wnt-3a that is encoded in the genome of human.


WIF1_HUMAN Wnt inhibitory factor 1 (sprot)

A Wnt inhibitory factor 1 that is encoded in the genome of human.


SOST_HUMAN Sclerostin (sprot)

A sclerostin that is encoded in the genome of human.


DACT1_HUMAN Dapper homolog 1 (sprot)

A dapper homolog 1 that is encoded in the genome of human.


WNT9A_HUMAN Protein Wnt-9a (sprot)

A protein Wnt-9a that is encoded in the genome of human.


LRP5_HUMAN Low-density lipoprotein receptor-related protein 5 (sprot)

A low-density lipoprotein receptor-related protein 5 that is encoded in the genome of human.


LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (sprot)

A low-density lipoprotein receptor-related protein 6 that is encoded in the genome of human.


DKK1_HUMAN Dickkopf-related protein 1 (sprot)

A dickkopf-related protein 1 that is encoded in the genome of human.


WNT4_HUMAN Protein Wnt-4 (sprot)

A protein Wnt-4 that is encoded in the genome of human.


SFRP1_HUMAN Secreted frizzled-related protein 1 (sprot)

A secreted frizzled-related protein 1 that is encoded in the genome of human.


KREM2_HUMAN Kremen protein 2 (sprot)

A Kremen protein 2 that is encoded in the genome of human.


SFRP2_HUMAN Secreted frizzled-related protein 2 (sprot)

A secreted frizzled-related protein 2 that is encoded in the genome of human.


KREM1_HUMAN Kremen protein 1 (sprot)

A Kremen protein 1 that is encoded in the genome of human.


DKK4_HUMAN Dickkopf-related protein 4 (sprot)

A dickkopf-related protein 4 that is encoded in the genome of human.


DKK2_HUMAN Dickkopf-related protein 2 (sprot)

A dickkopf-related protein 2 that is encoded in the genome of human.


posterior lateral line neuromast primordium migration

The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop.


heart valve development

The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.


spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.


regulation of retinoic acid biosynthetic process

Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process.


zona limitans intrathalamica formation

The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon.


superior colliculus development

The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain.


regulation of retinoic acid receptor signaling pathway

Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


rostrocaudal neural tube patterning

The process in which the neural tube is divided into specific regions along the rostrocaudal axis.


endothelial cell fate specification

The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.


cell proliferation in dorsal spinal cord

The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population.


cell proliferation in midbrain

The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.


CADH2_CHICK Cadherin-2 (sprot)

A cadherin-2 that is encoded in the genome of chicken.


TM230_HUMAN Transmembrane protein 230 (sprot)

A transmembrane protein 230 that is encoded in the genome of human.


SEPT4_HUMAN Septin-4 (sprot)

A septin-4 that is encoded in the genome of human.


posterior lateral line development

The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear.


fin development

The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure.


positive regulation of neurogenesis

Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.


posterior lateral line neuromast deposition

The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line.


posterior lateral line neuromast development

The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals.


regulation of cell proliferation involved in tissue homeostasis

Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue.


caudal fin development

The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure.


embryonic camera-type eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized during embryonic development.


embryonic camera-type eye formation

The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape.


GDP phosphatase activity

Catalysis of the reaction: GDP + H2O = GMP + phosphate.


carbohydrate binding

Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.


nucleic acid binding

Binding to a nucleic acid.


unfolded protein binding

Binding to an unfolded protein.


ER retention sequence binding

Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.


soluble NSF attachment protein activity

Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.


nucleotide binding

Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.


ATP-dependent peptidase activity

Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.


UDP-galactose transmembrane transporter activity

Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate.


oligopeptide transmembrane transporter activity

Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide.


glycolipid binding

Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate.


structural constituent of cuticle

The action of a molecule that contributes to the structural integrity of a cuticle.


syntaxin-1 binding

Binding to a syntaxin-1 SNAP receptor.


PDIA6_HUMAN Protein disulfide-isomerase A6 (sprot)

A protein disulfide-isomerase A6 that is encoded in the genome of human.


ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (sprot)

A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human.


negative regulation of IRE1-mediated unfolded protein response

Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response.


IL23A_HUMAN Interleukin-23 subunit alpha (sprot)

An interleukin-23 subunit alpha that is encoded in the genome of human.


peripheral nervous system axon ensheathment

The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.


response to virus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.


protein homotrimerization

The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.


response to molecule of bacterial origin

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.


regulation of hematopoietic progenitor cell differentiation

Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.


positive regulation of hematopoietic progenitor cell differentiation

Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.


positive regulation of type II interferon-mediated signaling pathway

Any process that increases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway.


RIG-I signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.


nuclear factor NF-kappa-B p105 subunit isoform 2 (human)

A nuclear factor NF-kappa-B p105 subunit isoform 3 that is encoded in the genome of human.


transcription factor NF-kappa-B subunit

A protein that has a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region.


CARD domain binding

Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.


ribosomal large subunit export from nucleus

The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.


regulation of chaperone-mediated protein folding

Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding.


'de novo' cotranslational protein folding

The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.


MHC class I peptide loading complex

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.


epithelial cell maturation involved in salivary gland development

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state.


ER overload response

The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.


mRNA destabilization

Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.


nuclear-transcribed mRNA catabolic process, no-go decay

The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation.


post-transcriptional gene silencing

The inactivation of gene expression that occurs after transcription.


CCA tRNA nucleotidyltransferase activity

Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate.


RNZ1_HUMAN Zinc phosphodiesterase ELAC protein 1 (sprot)

A zinc phosphodiesterase ELAC protein 1 that is encoded in the genome of human.


RIOK3_HUMAN Serine/threonine-protein kinase RIO3 (sprot)

A serine/threonine-protein kinase RIO3 that is encoded in the genome of human.


RIOK2_HUMAN Serine/threonine-protein kinase RIO2 (sprot)

A serine/threonine-protein kinase RIO2 that is encoded in the genome of human.


BYST_HUMAN Bystin (sprot)

A bystin that is encoded in the genome of human.


RIOK1_HUMAN Serine/threonine-protein kinase RIO1 (sprot)

A serine/threonine-protein kinase RIO1 that is encoded in the genome of human.


LTV1_HUMAN Protein LTV1 homolog (sprot)

A protein LTV1 that is encoded in the genome of human.


PNO1_HUMAN RNA-binding protein PNO1 (sprot)

An RNA-binding protein PNO1 that is encoded in the genome of human.


TSR1_HUMAN Pre-rRNA-processing protein TSR1 homolog (sprot)

A pre-rRNA-processing protein TSR1 that is encoded in the genome of human.


ANKZ1_HUMAN tRNA endonuclease ANKZF1 (sprot)

An ankyrin repeat and zinc finger domain-containing protein 1 that is encoded in the genome of human.


NEMF_HUMAN Ribosome quality control complex subunit NEMF (sprot)

A serologically defined colon cancer antigen 1 that is encoded in the genome of human.


negative regulation of RNA export from nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm.


response to cadmium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.


LDH6B_HUMAN L-lactate dehydrogenase A-like 6B (sprot)

An L-lactate dehydrogenase A-like 6B that is encoded in the genome of human.


negative regulation of retinoic acid receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


sulfatide binding

Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group.


MANF_HUMAN Mesencephalic astrocyte-derived neurotrophic factor (sprot)

A protein ARMET that is encoded in the genome of human.


BIP_HUMAN Endoplasmic reticulum chaperone BiP (sprot)

An endoplasmic reticulum chaperone BiP that is encoded in the genome of human.


ENPL_HUMAN Endoplasmin (sprot)

An endoplasmin that is encoded in the genome of human.


regulation of IRE1-mediated unfolded protein response

Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response.


chitin

An aminoglycan consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.


An N-acetyl-D-glucosaminyl group derived from N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosamine. A disaccharide group formed from the hydrolysis of chitin (a linear polymer of repeated GlcNAc units)


An N-acetyl-D-glucosaminyl group derived from N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosamine. A trisaccharide group formed from the hydrolysis of chitin (a linear polymer of repeated GlcNAc units).


retinoic acid receptor beta isoform 3 (mouse)

A retinoic acid receptor beta isoform 3 that is encoded in the genome of mouse.


retinoic acid receptor RXR-beta isoform Long (mouse)

A retinoic acid receptor RXR-beta (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28704-1.


cellular response to glucose stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.


positive regulation of cytokine production involved in inflammatory response

Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.


white fat cell proliferation

The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population.


PG12B_MOUSE Group XIIB secretory phospholipase A2-like protein (sprot)

A group XIIB secretory phospholipase A2-like protein that is encoded in the genome of mouse.


meiotic cell cycle phase

One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.


NOLC1_HUMAN Nucleolar and coiled-body phosphoprotein 1 (sprot)

A nucleolar phosphoprotein p130 that is encoded in the genome of human.


sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform mSERCA3B (mouse)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64518-1.


sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform SERCA3A (mouse)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform 2 that is encoded in the genome of mouse.


sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2 (mouse)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2 that is encoded in the genome of mouse.


Rab geranylgeranyltransferase activity

Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.


HERP1_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (sprot)

A homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein that is encoded in the genome of human.


IBP1_HUMAN Insulin-like growth factor-binding protein 1 (sprot)

An insulin-like growth factor-binding protein 1 that is encoded in the genome of human.


glyceryl-ether monooxygenase activity

Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine).


cardiolipin synthase (CMP-forming)

Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol.


phosphatidylserine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.


rRNA modification

The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.


epidermal growth factor receptor ligand maturation

Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor.


signaling receptor ligand precursor processing

The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.


EGF_MOUSE Pro-epidermal growth factor (sprot)

A pro-epidermal growth factor that is encoded in the genome of mouse.


EPHA1_HUMAN Ephrin type-A receptor 1 (sprot)

An ephrin type-A receptor 1 that is encoded in the genome of human.


EFNA2_HUMAN Ephrin-A2 (sprot)

An ephrin-A2 that is encoded in the genome of human.


EFNA1_HUMAN Ephrin-A1 (sprot)

An ephrin-A1 that is encoded in the genome of human.


EPHA2_HUMAN Ephrin type-A receptor 2 (sprot)

An ephrin type-A receptor 2 that is encoded in the genome of human.


EPHA3_HUMAN Ephrin type-A receptor 3 (sprot)

An ephrin type-A receptor 3 that is encoded in the genome of human.


EPHA8_HUMAN Ephrin type-A receptor 8 (sprot)

An ephrin type-A receptor 8 that is encoded in the genome of human.


EFNA3_HUMAN Ephrin-A3 (sprot)

An ephrin-A3 that is encoded in the genome of human.


EFNA4_HUMAN Ephrin-A4 (sprot)

An ephrin-A4 that is encoded in the genome of human.


EFNA5_HUMAN Ephrin-A5 (sprot)

An ephrin-A5 that is encoded in the genome of human.


EPHA5_HUMAN Ephrin type-A receptor 5 (sprot)

An ephrin type-A receptor 5 that is encoded in the genome of human.


EPHA7_HUMAN Ephrin type-A receptor 7 (sprot)

An ephrin type-A receptor 7 that is encoded in the genome of human.


EPHAA_HUMAN Ephrin type-A receptor 10 (sprot)

An ephrin type-A receptor 10 that is encoded in the genome of human.


EPHA6_HUMAN Ephrin type-A receptor 6 (sprot)

An ephrin type-A receptor 6 that is encoded in the genome of human.


free ubiquitin chain polymerization

The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein.


positive regulation of double-strand break repair via homologous recombination

Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination.


protein K27-linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein.


protein monoubiquitination

Addition of a single ubiquitin group to a protein.


proteasomal protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.


negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.


protein import into peroxisome matrix, receptor recycling

The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol.


protein import into peroxisome matrix, substrate release

The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane.


regulation of cellular response to insulin stimulus

Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.


positive regulation of T cell receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.


positive regulation of defense response to virus by host

Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.


negative regulation of defense response to virus by host

Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.


positive regulation of toll-like receptor 3 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway.


protein K11-linked ubiquitination

A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.


stress granule disassembly

The disaggregation of a stress granule into its constituent protein and RNA parts.


negative regulation of toll-like receptor 3 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway.


negative regulation of response to oxidative stress

Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress.


translation elongation factor activity

Functions in chain elongation during polypeptide synthesis at the ribosome.


translation release factor activity

Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.


Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.


ubiquitin

A proteolytic cleavage product that gives rise to a protein that corresponds to the stand-alone version of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P0CG48, 1-76.


RS20_HUMAN Small ribosomal subunit protein uS10 (sprot)

A 40S ribosomal protein S20 that is encoded in the genome of human.


G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (sprot)

A Ras GTPase-activating protein-binding protein 1 that is encoded in the genome of human.


RS3_HUMAN Small ribosomal subunit protein uS3 (sprot)

A 40S ribosomal protein S3 that is encoded in the genome of human.


Toll-like receptor 3 isoform h1 (human)

A Toll-like receptor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15455-1.


RAB1A_HUMAN Ras-related protein Rab-1A (sprot)

A Ras-related protein Rab-1A that is encoded in the genome of human.


biolink:MacromolecularComplex biolink:BiologicalEntity biolink:NamedThing biolink:MacromolecularMachineMixin biolink:ThingWithTaxon


BIRC5_HUMAN Baculoviral IAP repeat-containing protein 5 (sprot)

A baculoviral IAP repeat-containing protein 5 that is encoded in the genome of human.


ELOC_HUMAN Elongin-C (sprot)

An elongin-C that is encoded in the genome of human.


ELOB_HUMAN Elongin-B (sprot)

An elongin-B that is encoded in the genome of human.


SHPRH_HUMAN E3 ubiquitin-protein ligase SHPRH (sprot)

An E3 ubiquitin-protein ligase SHPRH that is encoded in the genome of human.


WAC_HUMAN WW domain-containing adapter protein with coiled-coil (sprot)

A WW domain-containing adapter protein with coiled-coil that is encoded in the genome of human.


RN181_HUMAN E3 ubiquitin-protein ligase RNF181 (sprot)

An E3 ubiquitin-protein ligase RNF181 that is encoded in the genome of human.


HLTF_HUMAN Helicase-like transcription factor (sprot)

A helicase-like transcription factor that is encoded in the genome of human.


ubiquitin-conjugating enzyme E2 J2 isoform h1 (human)

A ubiquitin-conjugating enzyme E2 J2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N2K1-1.


US11_HCMVA Unique short US11 glycoprotein (sprot)


BACH1_HUMAN Transcription regulator protein BACH1 (sprot)

A transcription regulator protein BACH1 that is encoded in the genome of human.


FXL17_HUMAN F-box/LRR-repeat protein 17 (sprot)

An F-box/LRR-repeat protein 17 that is encoded in the genome of human.


H2B1K_HUMAN Histone H2B type 1-K (sprot)

A histone H2B type 1-K that is encoded in the genome of human.


H2B1J_HUMAN Histone H2B type 1-J (sprot)

A histone H2B type 1-J that is encoded in the genome of human.


H2B1O_HUMAN Histone H2B type 1-O (sprot)

A histone H2B type 1-O that is encoded in the genome of human.


H2B1B_HUMAN Histone H2B type 1-B (sprot)

A histone H2B type 1-B that is encoded in the genome of human.


H2B1D_HUMAN Histone H2B type 1-D (sprot)

A histone H2B type 1-D that is encoded in the genome of human.


H2B1C_HUMAN Histone H2B type 1-C/E/F/G/I (sprot)

A histone H2B type 1-C/E/F/G/I that is encoded in the genome of human.


H2B1H_HUMAN Histone H2B type 1-H (sprot)

A histone H2B type 1-H that is encoded in the genome of human.


H2B1A_HUMAN Histone H2B type 1-A (sprot)

A histone H2B type 1-A that is encoded in the genome of human.


H2B1N_HUMAN Histone H2B type 1-N (sprot)

A histone H2B type 1-N that is encoded in the genome of human.


H2B1M_HUMAN Histone H2B type 1-M (sprot)

A histone H2B type 1-M that is encoded in the genome of human.


H2B1L_HUMAN Histone H2B type 1-L (sprot)

A histone H2B type 1-L that is encoded in the genome of human.


Q9MY60_HUMAN MHC Class I antigen (B60) (Fragment) (trembl)


RNF10_HUMAN E3 ubiquitin-protein ligase RNF10 (sprot)

A RING finger protein 10 that is encoded in the genome of human.


RNF8_HUMAN E3 ubiquitin-protein ligase RNF8 (sprot)

An E3 ubiquitin-protein ligase RNF8 that is encoded in the genome of human.


BRAP_HUMAN BRCA1-associated protein (sprot)

A BRCA1-associated protein that is encoded in the genome of human.


TM129_HUMAN E3 ubiquitin-protein ligase TM129 (sprot)

An E3 ubiquitin-protein ligase TM129 that is encoded in the genome of human.


RFFL_HUMAN E3 ubiquitin-protein ligase rififylin (sprot)

An E3 ubiquitin-protein ligase rififylin that is encoded in the genome of human.


ASCC3_HUMAN Activating signal cointegrator 1 complex subunit 3 (sprot)

An activating signal cointegrator 1 complex subunit 3 that is encoded in the genome of human.


ABCE1_HUMAN ATP-binding cassette sub-family E member 1 (sprot)

An ATP-binding cassette sub-family E member 1 that is encoded in the genome of human.


H2AX_HUMAN Histone H2AX (sprot)

A histone H2AX that is encoded in the genome of human.


endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs.


dosage compensation complex assembly

The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes.


PPIL2_HUMAN RING-type E3 ubiquitin-protein ligase PPIL2 (sprot)

A RING-type E3 ubiquitin-protein ligase PPIL2 that is encoded in the genome of human.


TCRG1_HUMAN Transcription elongation regulator 1 (sprot)

A transcription elongation regulator 1 that is encoded in the genome of human.


YJU2_HUMAN Splicing factor YJU2 (sprot)

A splicing factor YJU2 that is encoded in the genome of human.


DHX35_HUMAN Probable ATP-dependent RNA helicase DHX35 (sprot)

A probable ATP-dependent RNA helicase DHX35 that is encoded in the genome of human.


MFAP1_HUMAN Microfibrillar-associated protein 1 (sprot)

A microfibrillar-associated protein 1 that is encoded in the genome of human.


CWC27_HUMAN Spliceosome-associated protein CWC27 homolog (sprot)

A spliceosome-associated protein CWC27 homolog that is encoded in the genome of human.


GPKOW_HUMAN G-patch domain and KOW motifs-containing protein (sprot)

A G-patch domain and KOW motifs-containing protein that is encoded in the genome of human.


R113A_HUMAN E3 ubiquitin-protein ligase RNF113A (sprot)

An E3 ubiquitin-protein ligase RNF113A that is encoded in the genome of human.


REN3B_HUMAN Regulator of nonsense transcripts 3B (sprot)

A regulator of nonsense transcripts 3B that is encoded in the genome of human.


WDR70_HUMAN WD repeat-containing protein 70 (sprot)

A WD repeat-containing protein 70 that is encoded in the genome of human.


CASC3_HUMAN Protein CASC3 (sprot)

A protein CASC3 that is encoded in the genome of human.


CWC25_HUMAN Pre-mRNA-splicing factor CWC25 homolog (sprot)

A pre-mRNA-splicing factor CWC25 homolog that is encoded in the genome of human.


PPIL4_HUMAN Peptidyl-prolyl cis-trans isomerase-like 4 (sprot)

A peptidyl-prolyl cis-trans isomerase-like 4 that is encoded in the genome of human.


GPTC1_HUMAN G patch domain-containing protein 1 (sprot)

A G patch domain-containing protein 1 that is encoded in the genome of human.


NSRP1_HUMAN Nuclear speckle splicing regulatory protein 1 (sprot)

A nuclear speckle splicing regulatory protein 1 that is encoded in the genome of human.


WBP4_HUMAN WW domain-binding protein 4 (sprot)

A WW domain-binding protein 4 that is encoded in the genome of human.


PP1R8_HUMAN Nuclear inhibitor of protein phosphatase 1 (sprot)

A nuclear inhibitor of protein phosphatase 1 that is encoded in the genome of human.


PR38A_HUMAN Pre-mRNA-splicing factor 38A (sprot)

A pre-mRNA-splicing factor 38A that is encoded in the genome of human.


RBM5_HUMAN RNA-binding protein 5 (sprot)

An RNA-binding protein 5 that is encoded in the genome of human.


UBL5_HUMAN Ubiquitin-like protein 5 (sprot)

A ubiquitin-like protein 5 that is encoded in the genome of human.


PRP18_HUMAN Pre-mRNA-splicing factor 18 (sprot)

A pre-mRNA-splicing factor 18 that is encoded in the genome of human.


PQBP1_HUMAN Polyglutamine-binding protein 1 (sprot)

A polyglutamine-binding protein 1 that is encoded in the genome of human.


DNJC8_HUMAN DnaJ homolog subfamily C member 8 (sprot)

A DnaJ homolog subfamily C member 8 that is encoded in the genome of human.


CCAR1_HUMAN Cell division cycle and apoptosis regulator protein 1 (sprot)

A cell division cycle and apoptosis regulator protein 1 that is encoded in the genome of human.


ZMAT2_HUMAN Zinc finger matrin-type protein 2 (sprot)

A zinc finger matrin-type protein 2 that is encoded in the genome of human.


IF4A3_HUMAN Eukaryotic initiation factor 4A-III (sprot)

A eukaryotic initiation factor 4A-III that is encoded in the genome of human.


WBP11_HUMAN WW domain-binding protein 11 (sprot)

A WW domain-binding protein 11 that is encoded in the genome of human.


DHX9_HUMAN ATP-dependent RNA helicase A (sprot)

An ATP-dependent RNA helicase A that is encoded in the genome of human.


SMU1_HUMAN WD40 repeat-containing protein SMU1 (sprot)

A WD40 repeat-containing protein SMU1 that is encoded in the genome of human.


SNUT1_HUMAN U4/U6.U5 tri-snRNP-associated protein 1 (sprot)

A U4/U6.U5 tri-snRNP-associated protein 1 that is encoded in the genome of human.


RBM39_HUMAN RNA-binding protein 39 (sprot)

An RNA-binding protein 39 that is encoded in the genome of human.


RBM7_HUMAN RNA-binding protein 7 (sprot)

An RNA-binding protein 7 that is encoded in the genome of human.


RBM42_HUMAN RNA-binding protein 42 (sprot)

An RNA-binding protein 42 that is encoded in the genome of human.


RED_HUMAN Protein Red (sprot)

A protein Red that is encoded in the genome of human.


UBP39_HUMAN Ubiquitin carboxyl-terminal hydrolase 39 (sprot)

A U4/U6.U5 tri-snRNP-associated protein 2 that is encoded in the genome of human.


SF01_HUMAN Splicing factor 1 (sprot)

A splicing factor 1 that is encoded in the genome of human.


LC7L3_HUMAN Luc7-like protein 3 (sprot)

A cisplatin resistance-associated overexpressed protein that is encoded in the genome of human.


RBM25_HUMAN RNA-binding protein 25 (sprot)

An RNA-binding protein 25 that is encoded in the genome of human.


PR40A_HUMAN Pre-mRNA-processing factor 40 homolog A (sprot)

A pre-mRNA-processing factor 40 homolog A that is encoded in the genome of human.


SNR27_HUMAN U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (sprot)

A U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein that is encoded in the genome of human.


TXN4A_HUMAN Thioredoxin-like protein 4A (sprot)

A thioredoxin-like protein 4A that is encoded in the genome of human.


PRP6_HUMAN Pre-mRNA-processing factor 6 (sprot)

A pre-mRNA-processing factor 6 that is encoded in the genome of human.


post-transcriptional regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.


regulation of Golgi organization

Any process that modulates the frequency, rate or extent of Golgi organization.


protein localization to Golgi membrane

A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.


mitochondrion inheritance

The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton.


endoplasmic reticulum inheritance

The partitioning of endoplasmic reticulum between daughter cells at cell division.


Golgi inheritance

The partitioning of Golgi apparatus between daughter cells at cell division.


Golgi distribution to daughter cells

Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division.


regulation of carbohydrate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.


cytolysis in another organism

The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm.


adenylate cyclase-modulating G protein-coupled receptor signaling pathway

A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).


Golgi to plasma membrane transport

The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.


protein localization to early endosome

A process in which a protein is transported to, or maintained in, a location within an early endosome.


NAD-dependent protein depalmitoylase activity

Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.


3'-5' RNA helicase activity

Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis.


negative regulation of GTPase activity

Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.


Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.


translation termination factor activity

Functions in the termination of translation.


mitochondrial inner boundary membrane

The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane.


PELO_HUMAN Protein pelota homolog (sprot)

A protein pelota that is encoded in the genome of human.


SH3G2_HUMAN Endophilin-A1 (sprot)

An endophilin-A1 that is encoded in the genome of human.


TBC20_HUMAN TBC1 domain family member 20 (sprot)

A TBC1 domain family member 20 that is encoded in the genome of human.


RRFM_HUMAN Ribosome-recycling factor, mitochondrial (sprot)

A ribosome-recycling factor, mitochondrial that is encoded in the genome of human.


IF3M_HUMAN Translation initiation factor IF-3, mitochondrial (sprot)

A translation initiation factor IF-3, mitochondrial that is encoded in the genome of human.


IF2M_HUMAN Translation initiation factor IF-2, mitochondrial (sprot)

A translation initiation factor IF-2, mitochondrial that is encoded in the genome of human.


RASL2_HUMAN Ras GTPase-activating protein 4 (sprot)

A Ras GTPase-activating protein 4 that is encoded in the genome of human.


RASL1_HUMAN RasGAP-activating-like protein 1 (sprot)

A RasGAP-activating-like protein 1 that is encoded in the genome of human.


RASA3_HUMAN Ras GTPase-activating protein 3 (sprot)

A Ras GTPase-activating protein 3 that is encoded in the genome of human.


RASA2_HUMAN Ras GTPase-activating protein 2 (sprot)

A Ras GTPase-activating protein 2 that is encoded in the genome of human.


DAB2P_HUMAN Disabled homolog 2-interacting protein (sprot)

A disabled homolog 2-interacting protein that is encoded in the genome of human.


RASL3_HUMAN RAS protein activator like-3 (sprot)

A RAS protein activator like-3 that is encoded in the genome of human.


SYGP1_HUMAN Ras/Rap GTPase-activating protein SynGAP (sprot)

A Ras/Rap GTPase-activating protein SynGAP that is encoded in the genome of human.


NGAP_HUMAN Ras GTPase-activating protein nGAP (sprot)

A Ras GTPase-activating protein nGAP that is encoded in the genome of human.


ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (sprot)

A eukaryotic peptide chain release factor GTP-binding subunit ERF3A that is encoded in the genome of human.


HBS1L_HUMAN HBS1-like protein (sprot)

An HBS1-like protein that is encoded in the genome of human.


RRF2M_HUMAN Ribosome-releasing factor 2, mitochondrial (sprot)

An elongation factor G 2, mitochondrial that is encoded in the genome of human.


K1KB5_MOUSE Kallikrein 1-related peptidase b5 (sprot)

A kallikrein 1-related peptidase b5 that is encoded in the genome of mouse.


neuroepithelial stem cell

The stem cell from which glial precursor cell arises from.


anterior neural tube closure

The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline.


spinal cord motor neuron differentiation

The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


membrane hyperpolarization

The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.


planar cell polarity pathway involved in neural tube closure

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.


basal protein localization

Any process in which a protein is transported to, or maintained in, basal regions of the cell.


regulation of protein maturation

Any process that modulates the frequency, rate or extent of protein maturation.


autonomic ganglion

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion.


parasympathetic nerve

A nerve that is part of a parasympathetic nervous system [Automatically generated definition].


glial cell apoptotic process

Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.


vitamin metabolic process

The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.


acetylcholine metabolic process

The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.


corticospinal neuron axon guidance

The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues.


establishment of left/right asymmetry

The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves.


negative regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.


response to UV

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.


negative regulation of B cell proliferation

Any process that stops, prevents or reduces the rate or extent of B cell proliferation.


negative regulation of activated T cell proliferation

Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.


metamorphosis

A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster.


notochord regression

The developmental process in which the stucture of the notochord is destroyed in an embryo.


tendon formation

The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts.


face development

The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.


respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.


epithelial cell morphogenesis involved in placental branching

The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta.


lung lobe morphogenesis

The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.


cellular localization

A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.


positive regulation of circadian rhythm

Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.


positive regulation of hemopoiesis

Any process that activates or increases the frequency, rate or extent of hemopoiesis.


synaptic receptor adaptor activity

The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule.


nasal mucus

Mucus produced in the nasal cavity, by the respiratory segment of the nasal mucosa.


outer dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


ecto-epithelial cell of viscerocranial mucosa

An epithelial cell of the mucosa associated with facial skeleton.


respiratory ciliated cell

A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium.


apical cytoplasm

The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells.


subapical part of cell

The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina.


ciliary transition fiber

A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium).


multi-ciliated epithelial cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.


zonula adherens assembly

Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.


maintenance of ciliary planar beating movement pattern

Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement.


positive regulation of motile cilium assembly

Any process that activates or increases the frequency, rate or extent of motile cilium assembly.


dynein heavy chain binding

Binding to a heavy chain of the dynein complex.


DYHC1_MOUSE Cytoplasmic dynein 1 heavy chain 1 (sprot)

A cytoplasmic dynein 1 heavy chain 1 that is encoded in the genome of mouse.


cyclic nucleotide-gated monoatomic ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts.


voltage-gated monoatomic ion channel activity

Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


detection of cAMP

The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP.


otolith development

The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure.


neuromast hair cell development

The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.


meiotic cell cycle process involved in oocyte maturation

Any meiotic cell cycle process that is involved in oocyte maturation.


regulation of MAPK cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.


fibroblast growth factor receptor binding

Binding to a fibroblast growth factor receptor (FGFR).


neutrophil migration

The movement of a neutrophil within or between different tissues and organs of the body.


regulation of peptidase activity

Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.


Q6DR99_MOUSE Pro-neuregulin-1, membrane-bound isoform (trembl)

A pro-neuregulin-1, membrane-bound isoform (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6DR99.


SLIT2_HUMAN Slit homolog 2 protein (sprot)

A slit homolog 2 protein that is encoded in the genome of human.


DCD_HUMAN Dermcidin (sprot)

A dermcidin that is encoded in the genome of human.


gamma-secretase complex

A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.


protein unfolding

The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.


mitochondrial genome maintenance

The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.


Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP.


galactosyltransferase activity

Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


pseudohyphal growth

The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli.


invasive filamentous growth

The growth of colonies in filamentous chains of cells into a substrate.


CHM2A_HUMAN Charged multivesicular body protein 2a (sprot)

A charged multivesicular body protein 2a that is encoded in the genome of human.


GOSR1_HUMAN Golgi SNAP receptor complex member 1 (sprot)

A Golgi SNAP receptor complex member 1 that is encoded in the genome of human.


BET1L_HUMAN BET1-like protein (sprot)

A BET1-like protein that is encoded in the genome of human.


STX18_HUMAN Syntaxin-18 (sprot)

A syntaxin-18 that is encoded in the genome of human.


USE1_HUMAN Vesicle transport protein USE1 (sprot)

A vesicle transport protein USE1 that is encoded in the genome of human.


VAMP3_HUMAN Vesicle-associated membrane protein 3 (sprot)

A vesicle-associated membrane protein 3 that is encoded in the genome of human.


STX10_HUMAN Syntaxin-10 (sprot)

A syntaxin-10 that is encoded in the genome of human.


CHMP7_HUMAN Charged multivesicular body protein 7 (sprot)

A charged multivesicular body protein 7 that is encoded in the genome of human.


CHMP6_HUMAN Charged multivesicular body protein 6 (sprot)

A charged multivesicular body protein 6 that is encoded in the genome of human.


CHMP3_HUMAN Charged multivesicular body protein 3 (sprot)

A charged multivesicular body protein 3 that is encoded in the genome of human.


VPS4A_HUMAN Vacuolar protein sorting-associated protein 4A (sprot)

A vacuolar protein sorting-associated protein 4A that is encoded in the genome of human.


IST1_HUMAN IST1 homolog (sprot)

An IST1 homolog that is encoded in the genome of human.


CHM4B_HUMAN Charged multivesicular body protein 4b (sprot)

A charged multivesicular body protein 4b that is encoded in the genome of human.


CHM4C_HUMAN Charged multivesicular body protein 4c (sprot)

A charged multivesicular body protein 4c that is encoded in the genome of human.


C2D1B_HUMAN Coiled-coil and C2 domain-containing protein 1B (sprot)

A coiled-coil and C2 domain-containing protein 1B that is encoded in the genome of human.


CHM2B_HUMAN Charged multivesicular body protein 2b (sprot)

A charged multivesicular body protein 2b that is encoded in the genome of human.


CHM4A_HUMAN Charged multivesicular body protein 4a (sprot)

A charged multivesicular body protein 4a that is encoded in the genome of human.


ASCC2_HUMAN Activating signal cointegrator 1 complex subunit 2 (sprot)

An activating signal cointegrator 1 complex subunit 2 that is encoded in the genome of human.


octopamine receptor activity

Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist.


ochratoxin A biosynthetic process

The chemical reactions and pathways resulting in the formation of ochratoxin A.


zearalenone biosynthetic process

The chemical reactions and pathways resulting in the formation of zearalenone, a mycotoxin produced by several Fusarium species, is most commonly found as a contaminant in stored grain and has chronic estrogenic effects on mammals.


terrequinone A biosynthetic process

The chemical reactions and pathways resulting in the formation of terrequinone A.


regulation of catalytic activity

Any process that modulates the activity of an enzyme.


non-ribosomal peptide synthetase activity

Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization.


transcription regulator activator activity

A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification.


positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.


malonyl-CoA

The S-malonyl derivative of coenzyme A.


Acetyl coenzyme A

An acyl-CoA having acetyl as its S-acetyl component.


Ochratoxin A

A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.


TERREQUINONE A

A bisindole alkaloid that is quinone bearing a hydroxy substituent at position 2, a 3,3-dimethylallyl group at position 5 and two indol-3-yl groups at positions 3 and 6, one of which is carrying a 1,1-dimethylallyl group at position 2.


OTAD_ASPNC Flavin-dependent halogenase otaD (sprot)


OTAA_ASPNC Highly reducing polyketide synthase otaA (sprot)


OTAD_ASPC5 Flavin-dependent halogenase otaD (sprot)


ZEA1_GIBZE Non-reducing polyketide synthase ZEA1 (sprot)


TDIE_EMENI Probable methyltransferase tdiE (sprot)


uroporphyrinogen decarboxylase

A protein that is a translation product of the human UROD gene or a 1:1 ortholog thereof.


type II iodothyronine deiodinase

A protein that is a translation product of the human DIO2 gene or a 1:1 ortholog thereof.


type I iodothyronine deiodinase

A protein that is a translation product of the human DIO1 gene or a 1:1 ortholog thereof.


OTAB_ASPNC Nonribosomal peptide synthetase otaB (sprot)


OTAC_ASPNC Cytochrome P450 monooxygenase otaC (sprot)


OTAB_ASPC5 Nonribosomal peptide synthetase otaB (sprot)


OTAC_ASPC5 Cytochrome P450 monooxygenase otaC (sprot)


OTAA_ASPC5 Highly reducing polyketide synthase otaA (sprot)


ZEB2_GIBZE Transcription factor ZEB2 (sprot)


ZEA2_GIBZE Highly reducing polyketide synthase ZEA2 (sprot)


TDIB_EMENI Indole prenyltransferase tdiB (sprot)


TDIA_EMENI Didemethylasterriquinone D synthetase tdiA (sprot)


TDIC_EMENI Probable NADPH-dependent quinone reductase tdiC (sprot)


GDP-mannose biosynthetic process

The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.


alpha-D-mannose 1-phosphate

A D-mannose 1-phosphate with an alpha-configuration at the anomeric position.


Hydrochloric Acid

A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.


antigen processing and presentation of endogenous peptide antigen via MHC class I

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.


positive regulation of protein-pyridoxal-5-phosphate linkage

Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


US06_HCMVA Unique short US6 glycoprotein (sprot)


Golgi apparatus mannose trimming

Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus.


Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H+ + UDP.


endoplasmic reticulum quality control compartment

A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.


An N(4)-glycosylated asparagine residue in which the glycan moiety is a branched nonasaccharide consisting of seven D-mannosyl residues and two N-acetylglucosamine residues, one of which at the reducing end is bonded to the asparagine N(4) atom.


An N-glycan residue involved in post-translational modification of proteins.


An N(4)-glycosylated asparagine residue in which the glycan moiety is a branched decasaccharide consisting of eight D-mannosyl residues and two N-acetylglucosamine residues, one of which at the reducing end is bonded to the asparagine N(4) atom.


MA1A2_HUMAN Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (sprot)

A mannosyl-oligosaccharide 1,2-alpha-mannosidase IB that is encoded in the genome of human.


MA1A1_HUMAN Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (sprot)

A mannosyl-oligosaccharide 1,2-alpha-mannosidase IA that is encoded in the genome of human.


MA1C1_HUMAN Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (sprot)

A mannosyl-oligosaccharide 1,2-alpha-mannosidase IC that is encoded in the genome of human.


inosine catabolic process

The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.


AMP catabolic process

The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate.


dGMP catabolic process

The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate).


xanthine catabolic process

The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.


GMP catabolic process

The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate.


dAMP catabolic process

The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate).


IMP catabolic process

The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate.


hypoxanthine catabolic process

The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.


guanine catabolic process

The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.


deoxyinosine catabolic process

The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside.


deoxyguanosine catabolic process

The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose.


RL4_MOUSE Large ribosomal subunit protein uL4 (sprot)

A 60S ribosomal protein L4 that is encoded in the genome of mouse.


HMGB2_MOUSE High mobility group protein B2 (sprot)

A high mobility group protein B2 that is encoded in the genome of mouse.


3BP2_MOUSE SH3 domain-binding protein 2 (sprot)

An SH3 domain-binding protein 2 that is encoded in the genome of mouse.


KNDC1_MOUSE Kinase non-catalytic C-lobe domain-containing protein 1 (sprot)

A kinase non-catalytic C-lobe domain-containing protein 1 that is encoded in the genome of mouse.


PTPRO_MOUSE Receptor-type tyrosine-protein phosphatase O (sprot)

A receptor-type tyrosine-protein phosphatase O that is encoded in the genome of mouse.


3BP1_MOUSE SH3 domain-binding protein 1 (sprot)

A protein that is a translation product of the Sh3bp1 gene in mouse.


PO2F2_MOUSE POU domain, class 2, transcription factor 2 (sprot)

A POU domain, class 2, transcription factor 2 that is encoded in the genome of mouse.


ERMES complex

A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.


apoptotic process in response to mitochondrial fragmentation

Any apoptotic process that occurs as a result of mitochondrial fragmentation.


mannose metabolic process

The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.


D-mannose 6-phosphate

A mannose phosphate in which the phosphate group is attached to position 6.


The pyranose form of D-mannose 6-phosphate.


alpha-D-mannose 1-phosphate(2-)

An organophosphate oxoanion that is the dianion of alpha-D-mannose 1-phosphate.


Golgi medial cisterna

The middle Golgi cisterna (or cisternae).


positive regulation by host of viral process

A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected.


peptidyl-L-cysteine S-palmitoylation

The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine.


protein localization to membrane raft

A process in which a protein is transported to, or maintained in, a location within a membrane raft.


structural constituent of virion

The action of a molecule that contributes to the structural integrity of a virion.


estrogen receptor isoform h3 (human)

An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-3.


ESR2_HUMAN Estrogen receptor beta (sprot)

An estrogen receptor beta that is encoded in the genome of human.


ZDH20_HUMAN Palmitoyltransferase ZDHHC20 (sprot)

A palmitoyltransferase ZDHHC20 that is encoded in the genome of human.


HMOX1_HUMAN Heme oxygenase 1 (sprot)

A heme oxygenase 1 that is encoded in the genome of human.


HM13_HUMAN Minor histocompatibility antigen H13 (sprot)

A minor histocompatibility antigen H13 that is encoded in the genome of human.


calcium ion import into sarcoplasmic reticulum

The directed movement of calcium ions into a sarcoplasmic reticulum.


calcium ion-transporting ATPase complex

Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in).


cuticle development involved in collagen and cuticulin-based cuticle molting cycle

Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans.


positive regulation of protein processing

Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.


phagolysosome

A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.


4-Nitrophenyl butyrate

A butyrate ester resulting from the formal condensation of the hydroxy group of 4-nitrophenol with the carboxy group of butyric acid.


Presqualene monophosphate

A triterpenyl phosphate that is presqualene in which the hydroxy hydrogen has been replaced by a monophosphate group.


diketone

A compound that contains two ketone functionalities.


Pseudouridine

A C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine.


NLRP3 inflammasome complex

An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.


regulation of neutrophil chemotaxis

Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


regulation of sarcomere organization

Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


regulation of mitochondrion organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.


neuromast regeneration

The regrowth of a neuromast following its loss or destruction.


undifferentiated genital tubercle

The embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin.


lipid droplet formation

A process that results in the assembly, arrangement of constituent parts of a lipid droplet.


cytosolic lipolysis

The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases.


diacylglycerol metabolic process

The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.


regulation of multicellular organism growth

Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.


mammary gland development

The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.


glandular epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


partitioning defective 3 homolog isoform 3 (mouse)

A partitioning defective 3 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99NH2-3.


oocyte animal/vegetal axis specification

The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus.


regulation of glial cell differentiation

Any process that modulates the frequency, rate or extent of glia cell differentiation.


embryonic camera-type eye development

The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.


optic cup formation involved in camera-type eye development

The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle.


regulation of receptor internalization

Any process that modulates the frequency, rate or extent of receptor internalization.


notochord cell development

The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


rhombomere development

The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.


anterior lateral line development

The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear.


pigment cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte.


pronephric duct development

The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney.


trigeminal ganglion development

The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.


taste bud formation

The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors.


lateral line nerve development

The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


ganglion of central nervous system

A ganglion that is part of a central nervous system [Automatically generated definition].


optic chiasma

A decussation of the diencephalon where the fibers of the optic nerve cross.


spinal accessory motor neuron

A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord.


IAPP_MOUSE Islet amyloid polypeptide (sprot)

An islet amyloid polypeptide that is encoded in the genome of mouse.


clathrin adaptor complex

A membrane coat adaptor complex that links clathrin to a membrane.


palmitoleoyltransferase activity

Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule.


calyx of Held

The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.


negative regulation of synaptic vesicle exocytosis

Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis.


D7PBZ9_CARAU Syntaxin 3B (Fragment) (trembl)


cardiac jelly development

The process whose specific outcome is the progression of cardiac jelly over time, from its formation to the mature structure. The cardiac jelly is an acellular gelatinous matrix secreted by the myocardium and plays a central role in the septation of the heart.


endothelial to hematopoietic transition

The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium.


regulation of interleukin-13 production

Any process that modulates the frequency, rate, or extent of interleukin-13 production.


primitive erythrocyte differentiation

Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis.


forebrain neuroblast division

The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast.


elicited macrophage

A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive.


neural rod formation

The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts.


negative regulation of ceramide biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.


negative regulation of phosphatidylcholine biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process.


negative regulation of inositol biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of inositol biosynthetic process.


negative regulation of phosphatidylserine biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process.


negative regulation of pseudohyphal growth

Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth.


negative regulation of invasive growth in response to glucose limitation

Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation.


negative regulation of dipeptide transport

Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport.


mating type determination

Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms.


negative regulation of sterol import

Any process that stops, prevents or reduces the frequency, rate or extent of sterol import.


negative regulation of mating type switching

Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching.


positive regulation of induction of conjugation with cellular fusion

Any process that activates or increases the frequency, rate or extent of induction of conjugation with cellular fusion.


negative regulation of filamentous growth of a population of unicellular organisms

Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms.


negative regulation of arginine catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process.


negative regulation of oligopeptide transport

Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport.


protein poly-ADP-ribosylation

The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain.


histone H3K deacetylase activity

Catalysis of the reaction: histone H3 N6-acetyl-L-lysine + H2O = histone H3 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H3.


SKI_HUMAN Ski oncogene (sprot)

A ski oncogene that is encoded in the genome of human.


SNW1_HUMAN SNW domain-containing protein 1 (sprot)

A SNW domain-containing protein 1 that is encoded in the genome of human.


AT1B4_HUMAN Protein ATP1B4 (sprot)

A protein ATP1B4 that is encoded in the genome of human.


KCTD1_HUMAN BTB/POZ domain-containing protein KCTD1 (sprot)

A BTB/POZ domain-containing protein KCTD1 that is encoded in the genome of human.


KCD15_HUMAN BTB/POZ domain-containing protein KCTD15 (sprot)

A BTB/POZ domain-containing protein KCTD15 that is encoded in the genome of human.


SKIL_HUMAN Ski-like protein (sprot)

A ski-like protein that is encoded in the genome of human.


TGIF1_HUMAN Homeobox protein TGIF1 (sprot)

A homeobox protein TGIF1 that is encoded in the genome of human.


TGIF2_HUMAN Homeobox protein TGIF2 (sprot)

A homeobox protein TGIF2 that is encoded in the genome of human.


cellular response to increased oxygen levels

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.


tumor protein 63 isoform 6 (mouse)

A tumor protein 63 isoform 6 that is encoded in the genome of mouse.


FOG2_MOUSE Zinc finger protein ZFPM2 (sprot)

A zinc finger protein ZFPM2 that is encoded in the genome of mouse.


positive regulation of glial cell differentiation

Any process that activates or increases the frequency, rate or extent of glia cell differentiation.


negative regulation of glial cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.


gliogenesis

The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.


cellular response to dithiothreitol

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus.


oxoglutarate dehydrogenase (succinyl-transferring) activity

Catalysis of the reaction: 2-oxoglutarate + lipoamide + H+ = S-succinyldihydrolipoamide + CO2.


A nine-membered branched glucosamine oligosaccharide consisting of eight D-mannosyl residues and one N-acetylglucosamine residue (the latter being located at the reducing end). An intermediate glycan structure of glycosylated proteins.


isocitrate dehydrogenase complex (NAD+)

Complex that possesses isocitrate dehydrogenase (NAD+) activity.


oxoglutarate dehydrogenase complex

A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).


succinate-CoA ligase complex (ADP-forming)

A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP.


succinate-CoA ligase complex (GDP-forming)

A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.


gamma-aminobutyric acid:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in).


positive regulation of monoatomic ion transport

Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


CTNS_HUMAN Cystinosin (sprot)

A cystinosin that is encoded in the genome of human.


small conductance calcium-activated potassium channel protein 2 isoform 1 (mouse)

A small conductance calcium-activated potassium channel protein 2 isoform 1 that is encoded in the genome of mouse.


DEAF1_MOUSE Deformed epidermal autoregulatory factor 1 homolog (sprot)

A deformed epidermal autoregulatory factor 1 that is encoded in the genome of mouse.


ETS1_MOUSE Protein C-ets-1 (sprot)

A protein C-ets-1 that is encoded in the genome of mouse.


PAX7_MOUSE Paired box protein Pax-7 (sprot)

A paired box protein Pax-7 that is encoded in the genome of mouse.


COE3_MOUSE Transcription factor COE3 (sprot)

A transcription factor COE3 that is encoded in the genome of mouse.


COE2_MOUSE Transcription factor COE2 (sprot)

A transcription factor COE2 that is encoded in the genome of mouse.


COE1_MOUSE Transcription factor COE1 (sprot)

A transcription factor COE1 that is encoded in the genome of mouse.


T2FA_MOUSE General transcription factor IIF subunit 1 (sprot)

A general transcription factor IIF subunit 1 that is encoded in the genome of mouse.


IKZF4_MOUSE Zinc finger protein Eos (sprot)

A zinc finger protein Eos that is encoded in the genome of mouse.


PROX1_MOUSE Prospero homeobox protein 1 (sprot)

A prospero homeobox protein 1 that is encoded in the genome of mouse.


zinc finger protein ZFPM2 isoform 1 (mouse)

A zinc finger protein ZFPM2 isoform 1 that is encoded in the genome of mouse.


neural crest formation

The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.


regulation of mating-type specific transcription, DNA-templated

Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription.


negative regulation of white fat cell proliferation

Any process that stops or decreases the rate or extent of white fat cell proliferation.