extracellular matrix organization involved in endocardium development

A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.


biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase].


biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.


corticospinal tract

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract.


late endosome to Golgi transport

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The directed movement of substances from late endosomes to the Golgi.


An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoic acid.


A 3-oxo-fatty acyl-CoA arising from deprotonation of the phosphate and diphosphate functions of 3-oxodocosanoyl-CoA; principal microspecies at pH 7.3.


chitin synthase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1).


ecdysis, chitin-based cuticle

The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster.


cuticle

Tough but flexible, non-mineral outer coverings of an organism, or parts of an organism, that provide protection. Cuticles are non-homologous, differing in their origin, structure and chemical composition[WP].


hemolymphoid system

Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs.


photoreceptor inner segment layer

Layer of the retina composed of the inner segments of the photoreceptor cells.


response to leptin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].


STRN4_HUMAN Striatin-4 (sprot)

A striatin-4 that is encoded in the genome of human.


alpha-actinin binding

Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.


patched binding

Binding to a patched (ptc) protein, a receptor for hedgehog proteins.


olfactory behavior

The behavior of an organism in response to an odor.


response to cycloheximide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes.


DOK2_HUMAN Docking protein 2 (sprot)

A docking protein 2 that is encoded in the genome of human.


DOK6_HUMAN Docking protein 6 (sprot)

A docking protein 6 that is encoded in the genome of human.


DOK4_HUMAN Docking protein 4 (sprot)

A docking protein 4 that is encoded in the genome of human.


SHAN3_HUMAN SH3 and multiple ankyrin repeat domains protein 3 (sprot)

An SH3 and multiple ankyrin repeat domains protein 3 that is encoded in the genome of human.


PDLI7_HUMAN PDZ and LIM domain protein 7 (sprot)

A PDZ and LIM domain protein 7 that is encoded in the genome of human.


DOK5_HUMAN Docking protein 5 (sprot)

A docking protein 5 that is encoded in the genome of human.


regulation of actin filament-based process

Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.


wound healing, spreading of cells

The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.


choroidal cell of the eye

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A structural cell that is part of optic choroid.


cochlea auditory hair cell

An auditory hair cell found in the cochlea.


glutathione import into mitochondrion

The process in which glutathione is transported from the cytosol into the mitochondrial matrix.


mucosal immune response

An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.


negative regulation of autophagic cell death

Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death.


antigen processing and presentation of endogenous antigen

The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.


positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


intracellular amino acid homeostasis

A homeostatic process involved in the maintenance of a steady state level of amino acids within a cell.


regulation of pigmentation

Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism.


endothelial tip cell fate specification

The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels.


regulation of dopamine uptake involved in synaptic transmission

Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell.


positive regulation of dopamine uptake involved in synaptic transmission

Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell.


G protein-coupled receptor catabolic process

The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor.


GDP-mannose metabolic process

The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.


pronephric nephron tubule development

The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct.


PTPRD_HUMAN Receptor-type tyrosine-protein phosphatase delta (sprot)

A receptor-type tyrosine-protein phosphatase delta that is encoded in the genome of human.


positive regulation of protein localization to synapse

Any process that activates or increases the frequency, rate or extent of protein localization to synapse.


regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission.


positive regulation of synapse maturation

Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.


new growing cell tip

A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth.


group III metabotropic glutamate receptor activity

A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity.


dark adaptation

The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light.


maintenance of animal organ identity

The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


CD11B_HUMAN Cyclin-dependent kinase 11B (sprot)

A cyclin-dependent kinase 11B that is encoded in the genome of human.


mitotic sister chromatid cohesion, centromeric

The cell cycle process in which centromeres of sister chromatids are joined during mitosis.


synapse pruning

A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.


Sin3-type complex

Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.


Snt2C complex

A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p.


protein localization to nucleolar rDNA repeats

Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus.


nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by a nodal protein binding to an activin receptor on the surface of a target cell, which contributes to the establishment of lateral mesoderm with respect to the left and right halves.


maintenance of location

Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere.


regulation of lysosomal protein catabolic process

Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.


GABAergic neuron differentiation in basal ganglia

The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron.


response to thyroid hormone

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.


positive regulation of protein localization to early endosome

Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.


vestibular receptor cell stereocilium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells.


triplet codon-amino acid adaptor activity

The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis.


selenocysteine incorporation

The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine.


SHB_HUMAN SH2 domain-containing adapter protein B (sprot)

An SH2 domain-containing adapter protein B that is encoded in the genome of human.


SH22A_HUMAN SH2 domain-containing protein 2A (sprot)

An SH2 domain-containing protein 2A that is encoded in the genome of human.


peptidoglycan binding

Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.


negative regulation of response to endoplasmic reticulum stress

Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress.


positive regulation of RIG-I signaling pathway

Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway.


immunoglobulin production in mucosal tissue

The synthesis and release of immunoglobulin in the mucosal tissue.


L-ascorbic acid transmembrane transport

The process in which L-ascorbic acid is transported across a lipid bilayer, from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species.


regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission

Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission.


regulation of postsynaptic dense core vesicle exocytosis

Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis.


negative regulation of neurotransmitter secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.


regulation of neurotransmitter secretion

Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.


substance P secreting cell

A peptide hormone secreting cell that secretes substance P.


mRNA 5'-splice site recognition

Recognition of the intron 5'-splice site by components of the assembling spliceosome.


serine phosphorylation of STAT protein

The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


positive regulation of protein targeting to membrane

Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.


superior olivary nucleus maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


epinephrine secretion

The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system.


adrenal chromaffin cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles.


type I enteroendocrine cell

An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile.


mitotic spindle midzone

The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.


mitotic metaphase chromosome alignment

A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


regulation of vasoconstriction by circulating norepinephrine

Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.


longitudinal sarcoplasmic reticulum

The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae.


skeletal muscle adaptation

Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals.


regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction

Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


positive regulation of calcium ion-dependent exocytosis

Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.


negative regulation of synaptic plasticity

A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


negative regulation of protein export from nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.


acetylcholine binding

Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.


rRNA acetylation

The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


protein complex involved in cell adhesion

Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell.


inducible T-cell costimulator isoform 1 (human)

An inducible T-cell costimulator isoform 1 that is encoded in the genome of human.


TNR14_HUMAN Tumor necrosis factor receptor superfamily member 14 (sprot)

A tumor necrosis factor receptor superfamily member 14 that is encoded in the genome of human.


BTLA_HUMAN B- and T-lymphocyte attenuator (sprot)

A B- and T-lymphocyte attenuator that is encoded in the genome of human.


ICOSL_HUMAN ICOS ligand (sprot)

An ICOS ligand that is encoded in the genome of human.


positive regulation of centriole replication

Any process that activates or increases the frequency, rate or extent of centriole replication.


WW domain-binding protein 5 isoform 1 (mouse)

A transcription elongation factor A protein-like 9 isoform 1 that is encoded in the genome of mouse.


neuroblast fate determination

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.


regulation of timing of subpallium neuron differentiation

The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon.


platelet alpha granule

A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).


cerebellar granular layer morphogenesis

The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.


negative regulation of platelet activation

Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.


mating plug formation

The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males.


seminal vesicle epithelium development

The progression of the seminal vesicle epithelium over time, from its formation to the mature structure.


histone acetyltransferase binding

Binding to an histone acetyltransferase.


glutamate-cysteine ligase complex

An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine.


negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.


regulation of mitochondrial depolarization

Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.


regulation of interleukin-1 beta production

Any process that modulates the frequency, rate, or extent of interleukin-1 beta production.


Myb complex

A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.


leukocyte mediated cytotoxicity

The directed killing of a target cell by a leukocyte.


positive regulation of focal adhesion assembly

Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.


positive regulation of actin nucleation

Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.


ureteric bud invasion

The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros.


dynamin-1-like protein isoform m2 (mouse)

A dynamin-1-like protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8K1M6-2.


phospholipid catabolic process

The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.


regulation of phospholipase A2 activity

Any process that modulates the activity of the enzyme phospholipase A2.


regulation of phospholipid catabolic process

Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.


STAP2_HUMAN Signal-transducing adaptor protein 2 (sprot)

A signal-transducing adaptor protein 2 that is encoded in the genome of human.


proprioception involved in equilibrioception

The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity.


cellular response to interleukin-3

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.


neural fold bending

The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse.


midbrain-hindbrain boundary maturation during brain development

A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.


planar cell polarity pathway involved in outflow tract morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract.


heterotrimeric G-protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex.


pyruvate kinase PKM isoform M1 (mouse)

A pyruvate kinase PKM isoform M1 that is encoded in the genome of mouse.


regulation of epidermal cell differentiation

Any process that modulates the frequency, rate or extent of epidermal cell differentiation.


MutSalpha complex

A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.


guanine/thymine mispair binding

Binding to a double-stranded DNA region containing a G/T mispair.


mismatched DNA binding

Binding to a double-stranded DNA region containing one or more mismatches.


somatic recombination of immunoglobulin genes involved in immune response

The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.


positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.


negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.


MSH3_HUMAN DNA mismatch repair protein Msh3 (sprot)

A DNA mismatch repair protein Msh3 that is encoded in the genome of human.


MSH6_HUMAN DNA mismatch repair protein Msh6 (sprot)

A DNA mismatch repair protein Msh6 that is encoded in the genome of human.


convergent extension involved in somitogenesis

The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis.


tau-protein kinase activity

Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.


negative regulation of neuron maturation

Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.


positive regulation of peptidyl-threonine phosphorylation

Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


phosphatidylglycerol metabolic process

The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes.


cerebellar Purkinje cell layer maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


inhibition of neuroepithelial cell differentiation

Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.


salivary gland development

The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.


glandular epithelial cell development

The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


APOA_HUMAN Apolipoprotein(a) (sprot)

An apolipoprotein(a) that is encoded in the genome of human.


intussusceptive angiogenesis

The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.


keratinocyte migration

The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another.


nuclear receptor binding

Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.


myosin filament assembly

The aggregation, arrangement and bonding together of a filament composed of myosin molecules.


striated muscle cell apoptotic process

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.


stimulatory C-type lectin receptor signaling pathway

The series of molecular signals initiated by the binding of C-type lectin to its receptor on the surface of a target cell, and resulting in cellular activation.


natural killer cell inhibitory signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response.


regulation of forebrain neuron differentiation

Any process that modulates the frequency, rate or extent of forebrain neuron differentiation.


craniofacial suture morphogenesis

The process in which any suture between cranial and/or facial bones is generated and organized.


forebrain ventricular zone progenitor cell division

The mitotic division of a basal progenitor giving rise to two neurons.


stomach neuroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium.


lung neuroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium.


carotid body glomus cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia.


pituicyte

A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment.


myoepithelial cell of mammary gland

A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative.


calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration

The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations.


antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules.


protein localization to endoplasmic reticulum exit site

A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site.


membrane coat

Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.


copper ion transport

The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


5-methylcytosine metabolic process

The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA.


positive regulation of gene expression via CpG island demethylation

An epigenetic gene regulation mechanism that positively regulates gene expression by demethylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.


basal cortex

The region that lies just beneath the plasma membrane on the basal edge of a cell.


RNA metabolic process

The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


pinocytosis

An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane.


positive regulation of cell-matrix adhesion

Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.


optic fissure

Groove that is in the developing ventral optic cup and through which blood vessels pass to the enclosed mesenchyme[ZFA]. a ventral fissure in the developing optic cup through which blood vessels pass to the enclosed mesenchyme[Free online medical dictionary].


regulation of corticosterone secretion

Any process that modulates the frequency, rate or extent of corticosterone secretion.


squamous basal epithelial stem cell differentiation involved in prostate gland acinus development

The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate.


soft palate development

The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate.


negative regulation of cAMP-dependent protein kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.


importin-alpha family protein binding

Binding to a member of the importin-alpha family.


late recombination nodule

An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I.


meiotic spindle midzone assembly

The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis.


meiotic metaphase I homologous chromosome alignment

A cell cycle process whereby homlogous chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator) by the spindle machinery and centromere/kinetochore arrangement during meiosis I chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


DNA double-strand break processing involved in repair via single-strand annealing

The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing.


negative regulation of mesenchymal cell proliferation

Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


AATF_HUMAN Protein AATF (sprot)

A protein AATF that is encoded in the genome of human.


receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-2 (mouse)

A receptor tyrosine-protein kinase erbB-4 isoform 2 that is encoded in the genome of mouse.


TSC22 domain family protein 1 isoform 2 (mouse)

A TSC22 domain family protein 1 isoform 2 that is encoded in the genome of mouse.


Bcl-2-modifying factor isoform 2 (mouse)

A Bcl-2-modifying factor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by [LM]DPGAEPWHHNSEAETLSWSHPGE followed by the sequence in UniProtKB:Q91ZE9-1. It is uncertain whether Leu or Met is the starting residue. The authors in PMID:20706276 claim the use of a non-conventional CUG-translation initiation site.


Bcl-2-modifying factor isoform 1 (mouse)

A Bcl-2-modifying factor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91ZE9-1.


Bcl-2-like protein 1 isoform Bcl-X(S) (mouse)

A Bcl-2-like protein 1 isoform 2 that is encoded in the genome of mouse.


DLL3_HUMAN Delta-like protein 3 (sprot)

A delta-like protein 3 that is encoded in the genome of human.


NOGG_HUMAN Noggin (sprot)

A noggin that is encoded in the genome of human.


MESP2_HUMAN Mesoderm posterior protein 2 (sprot)

A mesoderm posterior protein 2 that is encoded in the genome of human.


PALS1_HUMAN Protein PALS1 (sprot)

A protein PALS1 that is encoded in the genome of human.


CRUM3_HUMAN Protein crumbs homolog 3 (sprot)

A protein crumbs homolog 3 that is encoded in the genome of human.


INADL_HUMAN InaD-like protein (sprot)

An InaD-like protein that is encoded in the genome of human.


CLD5_HUMAN Claudin-5 (sprot)

A claudin-5 that is encoded in the genome of human.


CLD4_HUMAN Claudin-4 (sprot)

A claudin-4 that is encoded in the genome of human.


CLD11_HUMAN Claudin-11 (sprot)

A claudin-11 that is encoded in the genome of human.


CLD7_HUMAN Claudin-7 (sprot)

A claudin-7 that is encoded in the genome of human.


CLD9_HUMAN Claudin-9 (sprot)

A claudin-9 that is encoded in the genome of human.


CLD14_HUMAN Claudin-14 (sprot)

A claudin-14 that is encoded in the genome of human.


CLD1_HUMAN Claudin-1 (sprot)

A claudin-1 that is encoded in the genome of human.


CLD15_HUMAN Claudin-15 (sprot)

A claudin-15 that is encoded in the genome of human.


CLD6_HUMAN Claudin-6 (sprot)

A claudin-6 that is encoded in the genome of human.


CLD8_HUMAN Claudin-8 (sprot)

A claudin-8 that is encoded in the genome of human.


CLD12_HUMAN Claudin-12 (sprot)

A claudin-12 that is encoded in the genome of human.


CLD17_HUMAN Claudin-17 (sprot)

A claudin-17 that is encoded in the genome of human.


CLD18_HUMAN Claudin-18 (sprot)

A claudin-18 that is encoded in the genome of human.


CLD20_HUMAN Claudin-20 (sprot)

A claudin-20 that is encoded in the genome of human.


CLD2_HUMAN Claudin-2 (sprot)

A claudin-2 that is encoded in the genome of human.


CLD10_HUMAN Claudin-10 (sprot)

A claudin-10 that is encoded in the genome of human.


CLD19_HUMAN Claudin-19 (sprot)

A claudin-19 that is encoded in the genome of human.


CLD22_HUMAN Claudin-22 (sprot)

A claudin-22 that is encoded in the genome of human.


CLD23_HUMAN Claudin-23 (sprot)

A claudin-23 that is encoded in the genome of human.


CLD16_HUMAN Claudin-16 (sprot)

A claudin-16 that is encoded in the genome of human.


calcitonin receptor activity

Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


negative regulation of T-helper 17 cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.


MRF binding

Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.


cell migration involved in endocardial cushion formation

The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


Fc-gamma receptor signaling pathway

The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.


multinuclear osteoclast differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.


positive regulation of cytochrome-c oxidase activity

Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity.


L-amino acid transport

The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of mammary gland epithelial cell proliferation

Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation.


epithelial cell differentiation involved in mammary gland alveolus development

The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.


superior olivary complex

A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system.


hematopoietic system

Anatomical system that is involved in the production of hematopoietic cells.


red nucleus

Large round nucleus located in the midbrain tegmentum, consisting of a magnocellular and parvicellular portion in most species studied.


rhombomere 3 lateral wall

A rhombomere lateral wall that is part of a rhombomere 3.


lipase activator activity

Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.


The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine.


N-terminal protein myristoylation

The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.


positive regulation of high voltage-gated calcium channel activity

Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.


voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.


hormone binding

Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.


chondroitin sulfate proteoglycan binding

Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.


CSPG2_MOUSE Versican core protein (sprot)

A versican core protein that is encoded in the genome of mouse.


regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.


olfactory receptor activity

Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.


mitochondrion distribution

Any process that establishes the spatial arrangement of mitochondria between and within cells.


regulation of CD8-positive, alpha-beta T cell differentiation

Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation.


kidney proximal convoluted tubule epithelial cell


regulation of guanylate cyclase activity

Any process that modulates the frequency, rate or extent of guanylate cyclase activity.


guanylate cyclase regulator activity

Modulates the activity of guanylate cyclase.


calcium sensitive guanylate cyclase activator activity

Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.


EMAL4_HUMAN Echinoderm microtubule-associated protein-like 4 (sprot)

An echinoderm microtubule-associated protein-like 4 that is encoded in the genome of human.


exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.


flap endonuclease activity

Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis.


manganese ion binding

Binding to a manganese ion (Mn).


mesenchymal stem cell maintenance involved in nephron morphogenesis

The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


adiponectin-activated signaling pathway

The series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


corticotrophin-releasing factor receptor activity

Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.


planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue.


SUN domain-containing protein 1 isoform m5 (mouse)

A SUN domain-containing protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9D666-5.


cellular heat acclimation

Any process that increases heat tolerance of a cell in response to high temperatures.


cardiac left ventricle morphogenesis

The process in which the left cardiac ventricle is generated and organized.


fibroblast growth factor production

The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


positive regulation of fibroblast growth factor production

Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


regulation of hair follicle cell proliferation

Any process that modulates the frequency, rate or extent of hair follicle cell proliferation.


positive regulation of cell maturation

Any process that activates or increases the frequency, rate or extent of cell maturation.


activin binding

Binding to activin, a dimer of inhibin-beta subunits.


sperm ejaculation

The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract.


activin receptor binding

Binding to an activin receptor.


INHBA_MOUSE Inhibin beta A chain (sprot)

An activin/inhibin beta A chain that is encoded in the genome of mouse.


response to peptide hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.


negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator.


negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress.


determination of bilateral symmetry

The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.


myosin heavy chain binding

Binding to a heavy chain of a myosin complex.


MYH6_MOUSE Myosin-6 (sprot)

A myosin-6 that is encoded in the genome of mouse.


MYO19_MOUSE Unconventional myosin-XIX (sprot)

A myosin-XIX that is encoded in the genome of mouse.


PTPRF_MOUSE Receptor-type tyrosine-protein phosphatase F (sprot)

A receptor-type tyrosine-protein phosphatase F that is encoded in the genome of mouse.


DUS3_MOUSE Dual specificity protein phosphatase 3 (sprot)

A dual specificity protein phosphatase 3 that is encoded in the genome of mouse.


thioether S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.


vitamin E biosynthetic process

The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


negative regulation of post-translational protein modification

Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification.


positive regulation of reciprocal meiotic recombination

Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.


histone lysine demethylation

The modification of a histone by the removal of a methyl group from a lysine residue.


melatonin receptor activity

Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.


prostaglandin J receptor activity

Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.


prostaglandin D receptor activity

Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.


cellular response to prostaglandin D stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus.


negative regulation of type B pancreatic cell apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.


negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.


positive regulation of type B pancreatic cell apoptotic process

Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.


regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane

Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane.


dynein intermediate chain binding

Binding to an intermediate chain of the dynein complex.


dynactin binding

Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity.


single-celled organism vegetative growth phase

A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods.


actomyosin structure organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.


positive regulation of peptidyl-tyrosine autophosphorylation

Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.


epithelial cell differentiation involved in salivary gland development

The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland.


BH4 domain binding

Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein.


neural fold elevation formation

The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm.


heat shock protein HSP 90-alpha, initiator methionine removed non-ubiquitinated 1 (mouse)

A heat shock protein HSP 90-alpha, initiator methionine removed form in mouse that lacks cross-linking to K63-linked polyubiquitin on one or more Lys residues by Hectd1.


delta-catenin binding

Binding to the delta subunit of the catenin complex.


regulation of protein localization to cell surface

Any process that modulates the frequency, rate or extent of protein localization to the cell surface.


positive regulation of protein O-linked glycosylation

Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation.


regulation of defense response to virus by host

Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.


CD8-positive, alpha-beta memory T cell

A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell.


positive regulation of pancreatic amylase secretion

Any process that activates or increases the frequency, rate or extent of pancreatic amylase secretion.


calcium-mediated signaling using intracellular calcium source

The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response.


spine apparatus membrane

The lipid bilayer surrounding the spine apparatus.


postsynaptic recycling endosome membrane

The lipid bilayer surrounding a postsynaptic recycling endosome.


extrinsic component of postsynaptic early endosome membrane

The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


postsynaptic endocytic zone membrane

The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta.


postsynaptic septin cytoskeleton

The portion of the septin cytoskeleton contained within the postsynapse.


presynaptic actin cytoskeleton

The actin cytoskeleton that is part of a presynapse.


postsynaptic endosome membrane

The lipid bilayer surrounding a postsynaptic endosome.


trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission

Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.


postsynaptic dense core vesicle exocytosis

The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels.


regulation of recycling endosome localization within postsynapse

Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.


regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane

Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.


maintenance of postsynaptic specialization structure

A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.


synaptic vesicle recycling via endosome

Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate.


neurotransmitter receptor transport, endosome to plasma membrane

The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles.


neurotransmitter receptor transport to postsynaptic membrane

The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.


establishment of endoplasmic reticulum localization to postsynapse

The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine.


retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission

Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.


calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration

The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations.


postsynaptic neurotransmitter receptor diffusion trapping

The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization.


postsynaptic membrane assembly

The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).


regulation of translation at postsynapse

Any process that regulates translation occurring at the postsynapse.


regulation of synaptic signaling by nitric oxide

Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide.


A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane.


regulation of postsynaptic neurotransmitter receptor diffusion trapping

Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping.


presynapse to nucleus signaling pathway

The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).


RNA polyadenylation at postsynapse

A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse.


presynaptic signal transduction

Signal transduction in which the initial step occurs in a presynapse.


regulation of modification of synapse structure, modulating synaptic transmission

Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission.


neurotransmitter receptor transport postsynaptic membrane to endosome

Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome.


postsynaptic endocytosis

A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.


postsynaptic cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.


presynaptic cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton.


regulation of protein catabolic process at presynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.


protein catabolic process, modulating synaptic transmission

Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.


NPTX1_HUMAN Neuronal pentraxin-1 (sprot)

A neuronal pentraxin-1 that is encoded in the genome of human.


NPTX2_HUMAN Neuronal pentraxin-2 (sprot)

A neuronal pentraxin-2 that is encoded in the genome of human.


IRPL2_HUMAN X-linked interleukin-1 receptor accessory protein-like 2 (sprot)

An X-linked interleukin-1 receptor accessory protein-like 2 that is encoded in the genome of human.


CCG5_HUMAN Voltage-dependent calcium channel gamma-5 subunit (sprot)

A voltage-dependent calcium channel gamma-5 subunit that is encoded in the genome of human.


ITB3_HUMAN Integrin beta-3 (sprot)

An integrin beta-3 that is encoded in the genome of human.


SLIK1_HUMAN SLIT and NTRK-like protein 1 (sprot)

A SLIT and NTRK-like protein 1 that is encoded in the genome of human.


SLIK2_HUMAN SLIT and NTRK-like protein 2 (sprot)

A SLIT and NTRK-like protein 2 that is encoded in the genome of human.


SLIK4_HUMAN SLIT and NTRK-like protein 4 (sprot)

A SLIT and NTRK-like protein 4 that is encoded in the genome of human.


SPTB1_HUMAN Spectrin beta chain, erythrocytic (sprot)

A spectrin beta chain, erythrocytic that is encoded in the genome of human.


SNX27_HUMAN Sorting nexin-27 (sprot)

A sorting nexin-27 that is encoded in the genome of human.


CLAP2_HUMAN CLIP-associating protein 2 (sprot)

A CLIP-associating protein 2 that is encoded in the genome of human.


apoptosis regulator BAX isoform Alpha (mouse)

An apoptosis regulator BAX isoform 1 that is encoded in the genome of mouse.


JIP4_HUMAN C-Jun-amino-terminal kinase-interacting protein 4 (sprot)

A C-Jun-amino-terminal kinase-interacting protein 4 that is encoded in the genome of human.


CDON_HUMAN Cell adhesion molecule-related/down-regulated by oncogenes (sprot)

A cell adhesion molecule-related/down-regulated by oncogenes that is encoded in the genome of human.


brother of CDO isoform h1 (human)

A brother of CDO (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BWV1-1.


BNIP2_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (sprot)

A BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 that is encoded in the genome of human.


cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration

The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex.


positive regulation of small GTPase mediated signal transduction

Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.


mast cell activation

The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.


response to interleukin-15

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus.


development of secondary male sexual characteristics

The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.


response to interleukin-2

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus.


response to interleukin-4

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.


development of secondary female sexual characteristics

The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.


mast cell migration

The movement of a mast cell within or between different tissues and organs of the body.


ERBB4_MOUSE Receptor tyrosine-protein kinase erbB-4 (sprot)

A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of mouse.


protein localization to nuclear pore

A process in which a protein is transported to, or maintained in, a nuclear pore.


LAG3_HUMAN Lymphocyte activation gene 3 protein (sprot)

A lymphocyte activation gene 3 protein that is encoded in the genome of human.


DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (sprot)

An MHC class II histocompatibility antigen alpha chain DRA that is encoded in the genome of human.


DQA2_HUMAN HLA class II histocompatibility antigen, DQ alpha 2 chain (sprot)

An MHC class II histocompatibility antigen alpha chain DQA2 that is encoded in the genome of human.


DQA1_HUMAN HLA class II histocompatibility antigen, DQ alpha 1 chain (sprot)

An MHC class II histocompatibility antigen alpha chain DQA1 that is encoded in the genome of human.


DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (sprot)

An MHC class II histocompatibility antigen beta chain DRB1 that is encoded in the genome of human.


DQB1_HUMAN HLA class II histocompatibility antigen, DQ beta 1 chain (sprot)

An MHC class II histocompatibility antigen beta chain DQB1 that is encoded in the genome of human.


DPB1_HUMAN HLA class II histocompatibility antigen, DP beta 1 chain (sprot)

An MHC class II histocompatibility antigen beta chain DPB1 that is encoded in the genome of human.


DQB2_HUMAN HLA class II histocompatibility antigen, DQ beta 2 chain (sprot)

An MHC class II histocompatibility antigen beta chain DQB2 that is encoded in the genome of human.


DRB4_HUMAN HLA class II histocompatibility antigen, DR beta 4 chain (sprot)

An MHC class II histocompatibility antigen beta chain DRB4 that is encoded in the genome of human.


DPA1_HUMAN HLA class II histocompatibility antigen, DP alpha 1 chain (sprot)

An MHC class II histocompatibility antigen alpha chain DPA1 that is encoded in the genome of human.


DRB3_HUMAN HLA class II histocompatibility antigen, DR beta 3 chain (sprot)

An MHC class II histocompatibility antigen beta chain DRB3 that is encoded in the genome of human.


DRB5_HUMAN HLA class II histocompatibility antigen, DR beta 5 chain (sprot)

An MHC class II histocompatibility antigen beta chain DRB5 that is encoded in the genome of human.


antigen processing and presentation of peptide antigen

The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.


negative regulation of mast cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process.


positive regulation of mast cell proliferation

Any process that activates or increases the rate or extent of mast cell proliferation.


positive regulation of mast cell differentiation

Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.


xanthophyll

A subclass of carotenoids consisting of the oxygenated carotenes.


cyclin-dependent protein kinase activity

Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.


R-SMAD binding

Binding to a receptor-regulated SMAD signaling protein.


DRD5_MACMU D(1B) dopamine receptor (Fragment) (sprot)


CAC1B_CHICK Voltage-dependent N-type calcium channel subunit alpha-1B (Fragment) (sprot)


dynein light intermediate chain binding

Binding to a light intermediate chain of the dynein complex.


IDLC_MOUSE Axonemal dynein light intermediate polypeptide 1 (sprot)

An axonemal dynein light intermediate polypeptide 1 that is encoded in the genome of mouse.


kidney loop of Henle medullary thick ascending limb epithelial cell

An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal medulla.


solute carrier family 12 member 1 isoform A (mouse)

A solute carrier family 12 member 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55014-1.


glycerol transmembrane transport

The directed movement of glycerol across a membrane. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


gallbladder primordium

A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops.


taste receptor binding

Binding to a taste receptor.


7SK snRNA binding

Binding to a 7SK small nuclear RNA (7SK snRNA).


salivary gland glandular cell

Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts.


antibacterial peptide secretion

The regulated release of an antibacterial peptide from a cell or a tissue.


enterocyte of epithelium of small intestine

An enterocyte that is part of the epithelium of small intestine.


desmosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.


cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway.


The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


dense core granule membrane

The lipid bilayer surrounding a dense core granule.


corticotropin secretion

The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus.


iron import into cell

The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.


Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O.


The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate.


HES1_MOUSE Transcription factor HES-1 (sprot)

A transcription factor HES-1 that is encoded in the genome of mouse.


mitotic DNA damage checkpoint signaling

A signal transduction process involved in mitotic DNA damage checkpoint.


male germ-line stem cell asymmetric division

The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes.


positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.


Cul2-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


negative regulation of growth

Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.


T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.


negative regulation of macrophage antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.


negative regulation of memory T cell differentiation

Any process that stops, prevents, or reduces the rate of memory T cell differentiation.


negative regulation of dendritic cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.


DNJA1_MOUSE DnaJ homolog subfamily A member 1 (sprot)

A DnaJ homolog subfamily A member 1 that is encoded in the genome of mouse.


Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.


positive regulation of vascular permeability

Any process that increases the extent to which blood vessels can be pervaded by fluid.


vascular endothelial growth factor receptor 1 binding

Binding to a vascular endothelial growth factor receptor 1.


semaphorin receptor binding

Binding to a semaphorin receptor.


PLGF_HUMAN Placenta growth factor (sprot)

A placenta growth factor that is encoded in the genome of human.


ERBB3_MOUSE Receptor tyrosine-protein kinase erbB-3 (sprot)

A receptor tyrosine-protein kinase erbB-3 that is encoded in the genome of mouse.


epidermal growth factor receptor phosphorylated form (mouse)

An epidermal growth factor receptor (mouse) that includes at least one phosphorylated tyrosine. UniProtKB:Q01279, MOD:00048.


receptor tyrosine-protein kinase erbB-4 phosphotyrosine form (mouse)

A receptor tyrosine-protein kinase erbB-4 (mouse) that includes at least one phosphorylated tyrosine. UniProtKB:Q61527, MOD:00048.


receptor tyrosine-protein kinase erbB-2 phosphotyrosine form (mouse)

A receptor tyrosine-protein kinase erbB-2 (mouse) that includes at least one phosphorylated tyrosine. UniProtKB:P70424, MOD:00048.


regulation of Rho protein signal transduction

Any process that modulates the frequency, rate or extent of Rho protein signal transduction.


defense response to nematode

A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.


arylesterase activity

Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate.


phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform 1 (mouse)

A phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform 1 that is encoded in the genome of mouse.


metanephric nephron tubule epithelial cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state.


negative regulation of cell adhesion involved in substrate-bound cell migration

The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction.


respiratory burst after phagocytosis

A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity.


negative regulation of hair follicle placode formation

Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.


fungiform papilla development

The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue.


endopeptidase activator activity

Binds to and increases the activity of an endopeptidase.


antigen processing and presentation of exogenous antigen

The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex.


positive regulation of reactive oxygen species biosynthetic process

Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process.


triglyceride mobilization

The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.


regulation of lipoprotein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.


cAMP metabolic process

The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


flotillin complex

A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.


regulation of actin binding

Any process that modulates the frequency, rate or extent of actin binding.


paracrine signaling

The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.


respiratory basal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell.


alveolar lamellar body

A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.


negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis

Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron.


branch elongation of an epithelium

The growth process in which a branch increases in length from its base to its tip.


nutrient reservoir activity

Functions in the storage of nutritious substrates.


central nervous system interneuron axonogenesis

Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region.


adipose macrophage

A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive.


midgut development

The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.


entry of viral genome into host nucleus through nuclear pore complex via importin

Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery.


stem cell fate specification

The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


B2MVI1_LAMFL Epsin 1 (Fragment) (trembl)


AP2B1_HUMAN AP-2 complex subunit beta (sprot)

An AP-2 complex subunit beta that is encoded in the genome of human.


AP2S1_HUMAN AP-2 complex subunit sigma (sprot)

An AP-2 complex subunit sigma that is encoded in the genome of human.


AP2M1_HUMAN AP-2 complex subunit mu (sprot)

An AP-2 complex subunit mu that is encoded in the genome of human.


regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.


UV protection

Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV.


planar cell polarity pathway involved in ventricular septum morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum.


negative regulation of substrate adhesion-dependent cell spreading

Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.


prostaglandin E2 receptor EP3 subtype isoform Alpha (mouse)

A prostaglandin E2 receptor EP3 subtype isoform 1 that is encoded in the genome of mouse.


TSN7_HUMAN Tetraspanin-7 (sprot)

A tetraspanin-7 that is encoded in the genome of human.


CD48_HUMAN CD48 antigen (sprot)

A CD48 molecule that is encoded in the genome of human.


MERTK_HUMAN Tyrosine-protein kinase Mer (sprot)

A tyrosine-protein kinase Mer that is encoded in the genome of human.


JAM2_HUMAN Junctional adhesion molecule B (sprot)

A junctional adhesion molecule B that is encoded in the genome of human.


SELPL_HUMAN P-selectin glycoprotein ligand 1 (sprot)

A P-selectin glycoprotein ligand 1 that is encoded in the genome of human.


FCAMR_HUMAN High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (sprot)

A high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor that is encoded in the genome of human.


SLAF5_HUMAN SLAM family member 5 (sprot)

A SLAM family member 5 that is encoded in the genome of human.


LYAM2_HUMAN E-selectin (sprot)

An E-selectin that is encoded in the genome of human.


C99L2_HUMAN CD99 antigen-like protein 2 (sprot)

A CD99 molecule-like protein 2 that is encoded in the genome of human.


CD2_HUMAN T-cell surface antigen CD2 (sprot)

A CD2 molecule that is encoded in the genome of human.


CD244_HUMAN Natural killer cell receptor 2B4 (sprot)

A natural killer cell receptor 2B4 that is encoded in the genome of human.


EPCAM_HUMAN Epithelial cell adhesion molecule (sprot)

An epithelial cell adhesion molecule that is encoded in the genome of human.


LEUK_HUMAN Leukosialin (sprot)

A leukosialin that is encoded in the genome of human.


SIRPG_HUMAN Signal-regulatory protein gamma (sprot)

A signal-regulatory protein gamma that is encoded in the genome of human.


GLPA_HUMAN Glycophorin-A (sprot)

A glycophorin-A that is encoded in the genome of human.


GLPC_HUMAN Glycophorin-C (sprot)

A glycophorin-C that is encoded in the genome of human.


GLPB_HUMAN Glycophorin-B (sprot)

A glycophorin-B that is encoded in the genome of human.


CEAM5_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 5 (sprot)

A carcinoembryonic antigen-related cell adhesion molecule 5 that is encoded in the genome of human.


OMPC_NEIGO Outer membrane protein P.IIC (sprot)


OPAC_NEIGO Opacity protein opA50 (Fragment) (sprot)


OP28_NEIGO Opacity protein V28 (Fragment) (sprot)


PSG1_HUMAN Pregnancy-specific beta-1-glycoprotein 1 (sprot)

A pregnancy-specific beta-1-glycoprotein 1 that is encoded in the genome of human.


PSG2_HUMAN Pregnancy-specific beta-1-glycoprotein 2 (sprot)

A pregnancy-specific beta-1-glycoprotein 2 that is encoded in the genome of human.


EBA1_PLAFC Erythrocyte-binding antigen 175 (sprot)


PSG9_HUMAN Pregnancy-specific beta-1-glycoprotein 9 (sprot)

A pregnancy-specific beta-1-glycoprotein 9 that is encoded in the genome of human.


PSG4_HUMAN Pregnancy-specific beta-1-glycoprotein 4 (sprot)

A pregnancy-specific beta-1-glycoprotein 4 that is encoded in the genome of human.


PSG6_HUMAN Pregnancy-specific beta-1-glycoprotein 6 (sprot)

A pregnancy-specific beta-1-glycoprotein 6 that is encoded in the genome of human.


OPAB_NEIGO Opacity protein opA51 (Fragment) (sprot)


OPAG_NEIGO Opacity protein opA52 (Fragment) (sprot)


OPAA_NEIGO Opacity protein opA53 (Fragment) (sprot)


OPAI_NEIGO Opacity protein opA54 (sprot)


OPAE_NEIGO Opacity protein opA55 (Fragment) (sprot)


OPAF_NEIGO Opacity protein opA56 (Fragment) (sprot)


OPAK_NEIGO Opacity protein opA57 (Fragment) (sprot)


OPA68_NEIGO Opacity protein opA68 (Fragment) (sprot)


OPAJ_NEIGO Opacity protein opA58 (sprot)


OPAD_NEIGO Opacity protein opA59 (Fragment) (sprot)


OPAH_NEIGO Opacity protein opA60 (Fragment) (sprot)


OPA65_NEIGO Opacity protein opA65 (Fragment) (sprot)


OPA66_NEIGO Opacity protein opA66 (Fragment) (sprot)


OPA67_NEIGO Opacity protein opA67 (Fragment) (sprot)


PSG7_HUMAN Pregnancy-specific beta-1-glycoprotein 7 (sprot)

A pregnancy-specific beta-1-glycoprotein 7 that is encoded in the genome of human.


PSG5_HUMAN Pregnancy-specific beta-1-glycoprotein 5 (sprot)

A pregnancy-specific beta-1-glycoprotein 5 that is encoded in the genome of human.


PSG3_HUMAN Pregnancy-specific beta-1-glycoprotein 3 (sprot)

A pregnancy-specific beta-1-glycoprotein 3 that is encoded in the genome of human.


Q76NM5_PLAF7 Erythrocyte binding antigen-140 (trembl)


GSLG1_HUMAN Golgi apparatus protein 1 (sprot)

A Golgi apparatus protein 1 that is encoded in the genome of human.


ESAM_HUMAN Endothelial cell-selective adhesion molecule (sprot)

An endothelial cell-selective adhesion molecule that is encoded in the genome of human.


Q9U4X0_PLAFA Putative erythrocyte binding protein EBL-1 (Fragment) (trembl)


PSG11_HUMAN Pregnancy-specific beta-1-glycoprotein 11 (sprot)

A pregnancy-specific beta-1-glycoprotein 11 that is encoded in the genome of human.


PSG8_HUMAN Pregnancy-specific beta-1-glycoprotein 8 (sprot)

A pregnancy-specific beta-1-glycoprotein 8 that is encoded in the genome of human.


Mullerian tubercle

An elevation on the wall of the embryonic urogenital sinus where the Müllerian ducts enter.


N-acetylglucosamine metabolic process

The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.


dosage compensation by inactivation of X chromosome

Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.


mature gamma-delta T cell

A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location.


syntaxin binding

Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.


metanephric glomerular basement membrane development

The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration.


plasma membrane tubulation

A membrane tubulation process occurring in a plasma membrane.


negative regulation of apoptotic process involved in morphogenesis

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis.


negative regulation of epithelial cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.


ovarian cumulus expansion

Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells.


(1->3)-beta-D-glucan binding

Binding to a (1->3)-beta-D-glucan.


trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse.


extracellular matrix structural constituent conferring compression resistance

A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.


TBB3_MOUSE Tubulin beta-3 chain (sprot)

A tubulin beta-3 chain that is encoded in the genome of mouse.


nephrogenic zone

Outer portion of the renal cortex. Site of formation of medullary and cortical elements.


positive regulation of inner ear receptor cell differentiation

Any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation.


A 2-methylpentadecenoyl-CoA in which the double bond is located at position 2 (geochemistry not specified).