Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.


thiamine pyrophosphate transmembrane transporter activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other.


dephospho-CoA kinase activity

Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+.


Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate.


biotinidase activity

Catalysis of the reaction: biotin amide + H2O = biotin + NH3.


protoheme IX farnesyltransferase activity

Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.


alpha-1,3-mannosyltransferase activity

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.


Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol.


Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H+ + phosphatidyl-N-methylethanolamine.


Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.


calcium-dependent protein serine/threonine phosphatase activity

Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.


Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+.


DNA N-glycosylase activity

Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.


Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA.


Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.


Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.


Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein].


oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor.


acetyl-CoA hydrolase activity

Catalysis of the reaction: acetyl-CoA + H2O = acetate + CoA + H+.


N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.


steroid 17-alpha-monooxygenase activity

Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.


steroid 11-beta-monooxygenase activity

Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.


carbamoyl-phosphate synthase (ammonia) activity

Catalysis of the reaction: 2 ATP + hydrogencarbonate + NH4+ = 2 ADP + carbamoyl phosphate + 2 H+ + phosphate.


thromboxane-A synthase activity

Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2).


L-ornithine transmembrane transporter activity

Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.


Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA.


phosphatidylglycerophosphatase activity

Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.


Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+.


5'-3' DNA/RNA helicase activity

Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis.


glycine N-benzoyltransferase activity

Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H+.


testosterone dehydrogenase [NAD(P)] activity

Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+.


steroid 21-monooxygenase activity

Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O.


C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity

Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.


Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.


methylenetetrahydrofolate dehydrogenase (NAD+) activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.


prostaglandin-I synthase activity

Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).


chondroitin 4-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate.


pyruvate dehydrogenase (acetyl-transferring) kinase activity

Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.


acetate CoA-transferase activity

Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.


S-adenosyl-L-methionine transmembrane transporter activity

Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.


12-hydroxyheptadecatrienoic acid synthase activity

Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA).


11-hydroxythromboxane B2 dehydrogenase activity

Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+.


O-palmitoyltransferase activity

Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule.


acetylcholine transmembrane transporter activity

Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.


pristanate-CoA ligase activity

Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA.


glyoxylate reductase (NADP+) activity

Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.


CMP-N-acetylneuraminate transmembrane transporter activity

Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other.


Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide.


alpha-1,2-mannosyltransferase activity

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.


glycolipid floppase activity

Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


alpha-1,6-mannosyltransferase activity

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage.


Glc3Man9GlcNAc2 oligosaccharide glucosidase activity

Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).


5'-3' RNA polymerase activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end.


GDP-fucose transmembrane transporter activity

Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.


Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.


rRNA (pseudouridine) methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule.


methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity

Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.


methylmalonyl-CoA epimerase activity

Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.


Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.


Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate.


Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction.


Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate.


thiosulfate sulfurtransferase activity

Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.


keratan sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.


Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide.


alpha-N-acetylglucosaminidase activity

Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.


beta-galactosidase activity

Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.


Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate.


L-iduronidase activity

Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate.


phosphotransferase activity, for other substituted phosphate groups

Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor).


ATP-dependent NAD(P)H-hydrate dehydratase activity

Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H+ + NADH + phosphate.


Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA.


linoleoyl-CoA desaturase activity

Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-CoA and add a fourth double bond (a (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA).


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R.


galactosylceramidase activity

Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.


glycolipid mannosyltransferase activity

Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage.


Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor.


Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine.


CoA hydrolase activity

Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group.


Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate.


omega-6 fatty acid desaturase activity

Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain.


Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.


3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity

Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2.


Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n.


3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity

Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+.


Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate.


carnitine O-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R.


Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine.


Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins.


Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.


cyclin-dependent protein serine/threonine kinase regulator activity

Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.


DNA-(apurinic or apyrimidinic site) endonuclease activity

Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).


5'-3' exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.


protein C-terminal methylesterase activity

Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol.


oxidized purine nucleobase lesion DNA N-glycosylase activity

Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.


N-acetyltransferase activity

Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.


SUMO activating enzyme activity

Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.


Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate.


histone H3K9 demethylase activity

Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein.


cholesterol monooxygenase (side-chain-cleaving) activity

Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.


oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.


single-strand selective uracil DNA N-glycosylase activity

Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA.


glycosylphosphatidylinositol phospholipase D activity

Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.


NADPH-hemoprotein reductase activity

Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.


Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester.


retinol isomerase activity

Catalysis of the reaction: all-trans-retinol = 11-cis-retinol.


peptide N-acetyltransferase activity

Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.


lipoyl(octanoyl) transferase activity

Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein].


DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates

Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN.


polynucleotide 3'-phosphatase activity

Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage.


aminomethyltransferase activity

Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.


lysozyme activity

Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan.


protein C-terminal leucine carboxyl O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein.


alpha-glucosidase activity

Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose.


[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity

Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate.


AKAP5_HUMAN A-kinase anchor protein 5 (sprot)

An A-kinase anchor protein 5 that is encoded in the genome of human.


Thymine

A pyrimidine nucleobase that is uracil in which the hydrogen at position 5 is replaced by a methyl group.


Thymidine

A pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase.


GRP75_HUMAN Stress-70 protein, mitochondrial (sprot)

A stress-70 protein, mitochondrial that is encoded in the genome of human.


Cupric cation

An ion of copper carrying a double positive charge.


Adenine

The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.


Zwitterionic form of L-leucine.


ZO1_HUMAN Tight junction protein ZO-1 (sprot)

A tight junction protein ZO-1 that is encoded in the genome of human.


Beta-Carotene

A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid.


IDH3G_HUMAN Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (sprot)

An isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial that is encoded in the genome of human.


N-Acetyl-L-aspartic acid

An N-acyl-L-aspartic acid in which the acyl group is specified as acetyl.


A pantothenate that is the conjugate base of (R)-pantothenic acid, obtained by deprotonation of the carboxy group.


Pyridoxal

A pyridinecarbaldehyde that is pyridine-4-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 5 respectively. The 4-carboxyaldehyde form of vitamin B6, it is converted into pyridoxal phosphate, a coenzyme for the synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.


Pyridoxine

A hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.


A zwitterionic form of N(6),N(6),N(6)-trimethyl-L-lysinium cation arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3


Nicotinic acid

A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.


N-acetyl-L-aspartyl-L-glutamate

A peptide anion obtained by deprotonation of the three carboxy groups of N-acetyl-Asp-Glu; major species at pH 7.3.


A nucleotide-sugar oxoanion that is the dianion of ADP-D-ribose(2-) arising from deprotonation of the phosphate OH groups; major species at pH 7.3.


peptide

Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.


Tyramine

A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine.


An aldehyde that is acetaldehyde substituted by a 5-hydroxyindol-3-yl group.


An acetylspermidine having the acetyl group at the N1-position.


Trication of N(1)-acetylspermine arising from protonation of the one primary and two secondary amino groups; major species at pH 7.3.


The 5-phosphonooxy derivative of L-lysine having erythro-stereochemistry.


phosphate monoester

An organic phosphate that is phosphoric acid in which one of the hydrogens is replaced by an organyl group.


Methylarsonous acid

A one-carbon compound that is arsonous acid in which the hydrogen attached to arsenic is replaced by a methyl group.


Acetaminophen sulfate

An aryl sulfate that is paracetamol in which the hydroxy group has been replaced by a sulfooxy group.


Dehydroepiandrosterone

An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.


[3H]dehydroepiandrosterone sulfate

The conjugate base of 3beta-hydroxyandrost-5-en-17-one 3-sulfate arising from deprotonation of the sulfate OH group; major species at pH 7.3.


Pregnenolone

A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.


An oxysterol that is cholesterol substituted at position 26 by a hydroxy group.


A member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group.


Estrone

A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.


S-Formylglutathione

A S-acylglutathione in which the acyl group specified is formyl.


Cysteamine

An amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.


S-Methyl-L-methionine

A sulfonium compound that is the conjugate acid of S-methyl-L-methioninate.


acylglucosaminylphosphatidylinositol

An inositol compound having acylglucosaminyl and phosphatidyl substituents on its hydroxy groups.


S-[(2E,6E)-farnesyl]-L-cysteine residue

An alpha-amino-acid residue derived from S-[(2E,6E)-farnesyl]-L-cysteine


A hexadecenal containing a double bond at position 2 (the trans-stereoisomer).


globoside

Any glycosphingolipid where the oligosaccharide component has an N-acetylgalactosaminyl residue at the non-reducing end.


glycerophospholipid

Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.


A monocarboxylic acid anion that is the conjugate base of  N-acetyl-L-cysteine, obtained by deprotonation of the carboxy group; major species at pH 7.3.


An inositol having myo- configuration substituted at position 1 by a phosphate group.


Glucose 6-phosphate

A glucopyranose ring with a phosphate replacing the hydroxy in the hydroxymethyl group at position 6.


limit dextrin

Limit dextrin is the remaining polymer produced by enzymatic hydrolysis of amylopectine with an amylase.


Brachiose

A glycosylglucose consisting of two D-glucopyranose units connected by an alpha-(1->6)-linkage.


A hydroxypregnenolone carrying an alpha-hydroxy group at position 17.


A cholestanoyl-CoA formed by thioester linkage between 3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid and coenzyme A.


A 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA in which the carbon at position 25 of the steroidal side chain has S configuration.


A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.


UDP-alpha-D-xylose

Dianion of UDP-alpha-D-xylose arising from deprotonation of both free diphosphate OH groups.


Folic Acid

An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.


(R)-Nadphx

A tetrahydronicotinamide adenine dinucleotide obtained by formal stero- and regioselective hydration across the 2,3-double bond in the nicotinyl ring of NADPH, with the hydroxy group located at position 2, having (R)-configuration.


GlcNAc-Gal-GlcNAc(S)-Gal

An amino tetrasaccharide comprised of two N-acetylated glucosamine residues, of which one is sulfated on O-6, and two galactosyl residues, of which one is at the reducing end. It is an intermediate in the keratan sulfate degradation pathway.


A linear heptasaccharide glycosyl group consisting of two N-acetylgalactosamine residues (both sulfated at the 4-position), one iduronic acid residue sulfated at the 2-position, one glucuronic acid residue and two galactosyl residues linked to a xylosyl residue at the reducing end.


An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.


Cocaine

A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.


A pyridine nucleoside consisting of 1,4-dihydronicotinamide with a beta-D-ribofuranosyl moiety at the 1-position.


quinone

Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).


Benzylaminium

The conjugate acid of benzylamine; major product at pH 7.3.


Ethanol

A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.


Meadowlactone

A delta-lactone obtained by intramolecular condensation of the 5-hydroxy and carboxy groups of 5-hydroxyicosanoic acid. A nonenzymatic oxidation product of arachidonic acid.


Anandamide

An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine.


Methimazole

A member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.


Trimethylamine

A tertiary amine that is ammonia in which each hydrogen atom is substituted by an methyl group.


A 2'-deoxyribonucleoside triphosphate oxoanion that is the tetraanion of 8-oxo-dGTP arising from deprotonation of the triphosphate OH groups. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


Major microspecies at pH 7.3.


Deoxyinosine diphosphate

A 2'-deoxyribonucleoside 5'-diphosphate obtained by deprotonation of the diphosphate OH groups of 2'-deoxyinosine  5'-diphosphate; major species at pH 7.3.


A nucleoside triphosphate(4-) obtained by global deprotonation of the triphosphate OH groups of 2-oxo-ATP; major microspecies at pH 7.3


Major microspecies at pH 7.3


A 2'-deoxyribonucleoside triphosphate oxoanion that is the tetraanion of 2'-deoxy-2-hydroxyadenosine 5'-triphosphate, arising from deprotonation of the triphosphate OH groups. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


L-selenomethionine

The L-enantiomer of selenomethionine.


Se-methylselenocysteine

An L-alpha-amino acid compound having methylselanylmethyl as the side-chain.


Iron, isotope of mass 56

An iron group element atom that has atomic number 26.


Zwitterionic form of L-threonine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3.


A monomethoxybenzene that is dopamine in which the hydroxy group at position 3 is replaced by a methoxy group. It is a metabolite of the neurotransmitter dopamine and considered a potential biomarker of pheochromocytomas and paragangliomas.


An L-alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of L-isoleucine; major species at pH 7.3.


The L-enantiomer of histidinium(1+).


The amino acid zwitterion formed from 4-hydroxy-L-proline. It is the major microspecies present at pH 7.3.


D-Aspartic acid

The D-enantiomer of aspartic acid.


Pristanoyl-CoA in which C-2 of the pristanoyl group has S-configuration.


An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of cis-3-octenoic acid.


2-Hydroxyhexadecanoic acid

A 2-hydroxy fatty acid comprising a C16 straight chain carrying a hydroxy substituent at position 2.


Cystine

The L-enantiomer of the sulfur-containing amino acid cystine.


A trisaccharide consisting of D-glucuronic acid, alpha-D-xylosyl and D-glucuronic acid residues joined in sequence by (1->3)-linkages. A repeating unit in glycoprotein DAG1


A glycosylglucopyranuronic acid consisting of alpha-D-xylosyl and D-glucuronic acid residues joined by a (1->3)-linkage. A repeating structure in glycoproteins.


IdCTP

A 2'-deoxycytidine phosphate that is 2'-deoxycytidine-5'-triphosphate in which the hydrogen at position 5 on the cytosine ring is replaced by iodine.


aflatoxin B1 dialdehyde

A 1,4-dialdehyde compound having a hydroxy substituent at the 2-position and a 7-hydroxy-9-methoxy-3,4-dioxo-1,4-dihydro-3H-furo[3,4-c]chromen-6-yl group at the 3-position.


Aflatoxin B1 endo-8,9-epoxide

A member of the class of aflatoxins that is obtained by the formal epoxidation across the 8,9-double bond of aflatoxin B1.


Sorbitol

The D-enantiomer of glucitol (also known as D-sorbitol).


L-gulonate

The L-enantiomer of gulonate.


A medium-chain unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of cis,cis-dodeca-3,6-dienoic acid.


L-threonylcarbamoyladenylate

A threonine derivative that is L-threonine in which one of the amino hydrogens is substituted by and adenyloxycarbonyl group


alpha-L-fucopyranose

An L-fucopyranose having alpha-configuration at the anomeric centre.


A GDP-sugar having 4-dehydro-6-deoxy-alpha-D-mannose as the sugar portion.


Methylglyoxal

A 2-oxo aldehyde derived from propanal.


(R)-S-lactoylglutathione

The S-[(R)-lactoyl] derivative of glutathione. It is an intermediate in the pyruvate metabolism.


Urocanic acid

A urocanic acid in which the double bond of the carboxyethene moiety has E configuration.


S-(Hydroxymethyl)glutathione

An S-substituted glutathione that is glutathione in which the mercapto hydrogen has been replaced by a hydroxymethyl group.


2-deoxy-alpha-D-ribose 1-phosphate(2-)

Dianion of 2-deoxy-alpha-D-ribose 1-phosphate.


Pseudouridine 5'-phosphate

A C-nucleoside phosphate consisting of pseudouridine having a monophosphate group at the 5'-position.


A methyladenosine compound with one methyl group attached to N(6) of the adenine nucleobase.


XTP tetraanion

A nucleoside triphosphate(4-) obtained by global deprotonation of the triphosphate OH groups of XTP; major species present at pH 7.3.


dITP tetraanion

A 2'-deoxyribonucleoside 5'-triphosphate(4-) that is the tetraanion of 2'-deoxyinosine 5'-triphosphate(dITP), arising from deprotonation of the four free OH groups of the triphosphate; major species at pH 7.3.


ITP tetraanion

A nucleoside triphosphate(4-) obtained by global deprotonation of the triphosphate OH groups of ITP; major species present at pH 7.3.


The conjugate base of (R)-3-hydroxybutyric acid.


medium-chain fatty acyl-CoA

A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any medium-chain fatty acid.


long-chain fatty acyl-CoA

A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any long-chain (C13 to C22) fatty acid.


GlcNAc (Man)9

A ten-membered branched glucosamine oligosaccharide consisting of nine D-mannosyl residues and one N-acetylglucosamine residue (the latter being located at the reducing end). An intermediate glycan structure of glycosylated proteins


Geranylgeranyl diphosphate

The all-trans-isomer of geranylgeranyl diphosphate.


A 2'-deoxyribonucleoside triphosphate oxoanion being the tetraanion formed by global deprotonation of the triphosphate group.


phytosterols

Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.


A dicarboxylic acid dianion resuting from removal of a proton from both carboxy groups of 4-fumarylacetoacetic acid.


Homogentisate

A dihydroxy monocarboxylic acid anion that is the conjugate base of (2,6-dihydroxyphenyl)acetic (homogentisic) acid, arising from deprotonation of the carboxy group.


Aspartame

A dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener.


An alpha-D-galactosyl group derived from alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-D-Gal-yl group. The blood group O (H) antigen from which subsequent sugar additions form blood groups A, B and AB


An alpha-D-galactosyl group derived from alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-alpha-D-Gal-yl group. The H (O) antigen formed from a Type 1 precursor chain.


An N(4)-glycosylated asparagine residue in which the glycan moiety is a branched octasaccharide consisting of five D-mannosyl residues and three N-acetylglucosamine residues, one of which at the reducing end is bonded to the asparagine N(4) atom.


Pyridoxamine

A monohydroxypyridine that is pyridine substituted by a hydroxy group at position 3, an aminomethyl group at position 4, a hydroxymethyl group at position 5 and a methyl group at position 2. The 4-aminomethyl form of vitamin B6, it is used (in the form of the hydrochloride salt) for treatment of diabetic nephropathy.


N-glycan

The term used to refer to the carbohydrate portion of N-glycoproteins when attached to a nitrogen from asparagine or arginine side-chains.


Ribavirin 5'-diphosphate(3-)

An organophosphate oxoanion resulting from the removal of the three diphosphate OH groups of  ribavirin 5'-diphosphate. It is the major species at pH 7.3.


A zwitterion formed from ciprofloxacin by transfer of a proton from the carboxy to the amino group; major species at pH 7.3.


L-Cysteic acid

The L-enantiomer of cysteic acid.


STX4_HUMAN Syntaxin-4 (sprot)

A syntaxin-4 that is encoded in the genome of human.


n-Oleoylethanolamine

An N-(long-chain-acyl)ethanolamine that is the ethanolamide of oleic acid. The monounsaturated analogue of the endocannabinoid anandamide.


A pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position.


Palmitoylethanolamide

An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid.


conjugated protein

Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion.


BAP31_HUMAN B-cell receptor-associated protein 31 (sprot)

A B-cell receptor-associated protein 31 that is encoded in the genome of human.


LMNB1_HUMAN Lamin-B1 (sprot)

A lamin-B1 that is encoded in the genome of human.


amino-acid residue

When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue.


SERPH_HUMAN Serpin H1 (sprot)

A serpin H1 that is encoded in the genome of human.


SMD2_HUMAN Small nuclear ribonucleoprotein Sm D2 (sprot)

A small nuclear ribonucleoprotein Sm D2 that is encoded in the genome of human.


RUXF_HUMAN Small nuclear ribonucleoprotein F (sprot)

A small nuclear ribonucleoprotein F that is encoded in the genome of human.


RUXG_HUMAN Small nuclear ribonucleoprotein G (sprot)

A small nuclear ribonucleoprotein G that is encoded in the genome of human.


SMD3_HUMAN Small nuclear ribonucleoprotein Sm D3 (sprot)

A small nuclear ribonucleoprotein Sm D3 that is encoded in the genome of human.


SMD1_HUMAN Small nuclear ribonucleoprotein Sm D1 (sprot)

A small nuclear ribonucleoprotein Sm D1 that is encoded in the genome of human.


RSMB_HUMAN Small nuclear ribonucleoprotein-associated proteins B and B' (sprot)

A small nuclear ribonucleoprotein-associated proteins B and B' that is encoded in the genome of human.


RUXE_HUMAN Small nuclear ribonucleoprotein E (sprot)

A small nuclear ribonucleoprotein E that is encoded in the genome of human.


VAMP8_HUMAN Vesicle-associated membrane protein 8 (sprot)

A vesicle-associated membrane protein 8 that is encoded in the genome of human.


VAMP7_HUMAN Vesicle-associated membrane protein 7 (sprot)

A vesicle-associated membrane protein 7 that is encoded in the genome of human.


ZO2_HUMAN Tight junction protein ZO-2 (sprot)

A tight junction protein ZO-2 that is encoded in the genome of human.


GNAT1_HUMAN Guanine nucleotide-binding protein G(t) subunit alpha-1 (sprot)

A guanine nucleotide-binding protein G(t) subunit alpha-1 that is encoded in the genome of human.


prelamin-A/C isoform A (human)

A prelamin-A/C isoform A that is encoded in the genome of human.


PKP1_HUMAN Plakophilin-1 (sprot)

A plakophilin-1 that is encoded in the genome of human.


DESP_HUMAN Desmoplakin (sprot)

A desmoplakin that is encoded in the genome of human.


OCLN_HUMAN Occludin (sprot)

An occludin that is encoded in the genome of human.


2,3-trans-enoyl CoA(4-)

An acyl-CoA(4-) oxoanion arising from deprotonation of the phosphate and diphosphate OH groups of any 2,3-trans-enoyl CoA; major species at pH 7.3.


E41L1_HUMAN Band 4.1-like protein 1 (sprot)

A band 4.1-like protein 1 that is encoded in the genome of human.


DLG1_HUMAN Disks large homolog 1 (sprot)

A disks large homolog 1 that is encoded in the genome of human.


PRIC1_HUMAN Prickle-like protein 1 (sprot)

A prickle-like protein 1 that is encoded in the genome of human.


TRAF1_HUMAN TNF receptor-associated factor 1 (sprot)

A TNF receptor-associated factor 1 that is encoded in the genome of human.


An organic anionic group obtained by deprotonation of the phosphate OH group of N(1)-methylguanosine 5'-monophosphate residue.


adenosine residue

The nucleoside residue formed from adenosine with linkages at the 3' and 5' positions.


guanosine residue

The nucleoside residue formed from guanosine with linkages at the 3' and 5' positions.


IF4H_HUMAN Eukaryotic translation initiation factor 4H (sprot)

A eukaryotic translation initiation factor 4H that is encoded in the genome of human.


A hydroxy fatty acid anion that is the conjugate base of 3-hydroxybutyric acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


VLDLR_HUMAN Very low-density lipoprotein receptor (sprot)

A very low-density lipoprotein receptor that is encoded in the genome of human.


EMRE_HUMAN Essential MCU regulator, mitochondrial (sprot)

An essential MCU regulator, mitochondrial that is encoded in the genome of human.


SODM_HUMAN Superoxide dismutase [Mn], mitochondrial (sprot)

A superoxide dismutase [Mn], mitochondrial that is encoded in the genome of human.


RHBT2_HUMAN Rho-related BTB domain-containing protein 2 (sprot)

A Rho-related BTB domain-containing protein 2 that is encoded in the genome of human.


H2A1C_HUMAN Histone H2A type 1-C (sprot)

A histone H2A type 1-C that is encoded in the genome of human.


N4BP1_HUMAN NEDD4-binding protein 1 (sprot)

A NEDD4-binding protein 1 that is encoded in the genome of human.


IMA8_HUMAN Importin subunit alpha-8 (sprot)

An importin subunit alpha-8 that is encoded in the genome of human.


IMA4_HUMAN Importin subunit alpha-4 (sprot)

An importin subunit alpha-4 that is encoded in the genome of human.


IMA6_HUMAN Importin subunit alpha-6 (sprot)

An importin subunit alpha-6 that is encoded in the genome of human.


CISY_HUMAN Citrate synthase, mitochondrial (sprot)

A citrate synthase, mitochondrial that is encoded in the genome of human.


DHE3_HUMAN Glutamate dehydrogenase 1, mitochondrial (sprot)

A glutamate dehydrogenase 1, mitochondrial that is encoded in the genome of human.


H2A1B_HUMAN Histone H2A type 1-B/E (sprot)

A histone H2A type 1-B/E that is encoded in the genome of human.


CY1_HUMAN Cytochrome c1, heme protein, mitochondrial (sprot)

A cytochrome c1, heme protein, mitochondrial that is encoded in the genome of human.


H2A1_HUMAN Histone H2A type 1 (sprot)

A histone H2A type 1-G/I/K/L/M that is encoded in the genome of human.


H2A1D_HUMAN Histone H2A type 1-D (sprot)

A histone H2A type 1-D that is encoded in the genome of human.


ATPA_HUMAN ATP synthase subunit alpha, mitochondrial (sprot)

An ATP synthase subunit alpha, mitochondrial that is encoded in the genome of human.


LYOX_HUMAN Protein-lysine 6-oxidase (sprot)

A protein-lysine 6-oxidase that is encoded in the genome of human.


IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial (sprot)

An isocitrate dehydrogenase [NADP], mitochondrial that is encoded in the genome of human.


DHE4_HUMAN Glutamate dehydrogenase 2, mitochondrial (sprot)

A glutamate dehydrogenase 2, mitochondrial that is encoded in the genome of human.


LOXL1_HUMAN Lysyl oxidase homolog 1 (sprot)

A lysyl oxidase homolog 1 that is encoded in the genome of human.


H2A2C_HUMAN Histone H2A type 2-C (sprot)

A histone H2A type 2-C that is encoded in the genome of human.


H2A2A_HUMAN Histone H2A type 2-A (sprot)

A histone H2A type 2-A that is encoded in the genome of human.


H2A3_HUMAN Histone H2A type 3 (sprot)

A histone H2A type 3 that is encoded in the genome of human.


H2A2B_HUMAN Histone H2A type 2-B (sprot)

A histone H2A type 2-B that is encoded in the genome of human.


LOXL4_HUMAN Lysyl oxidase homolog 4 (sprot)

A lysyl oxidase homolog 4 that is encoded in the genome of human.


H2A1H_HUMAN Histone H2A type 1-H (sprot)

A histone H2A type 1-H that is encoded in the genome of human.


H2A1J_HUMAN Histone H2A type 1-J (sprot)

A histone H2A type 1-J that is encoded in the genome of human.


BCS1_HUMAN Mitochondrial chaperone BCS1 (sprot)

A mitochondrial chaperone BCS1 that is encoded in the genome of human.


LOXL2_HUMAN Lysyl oxidase homolog 2 (sprot)

A lysyl oxidase homolog 2 that is encoded in the genome of human.


D-alanine

The D-enantiomer of alanine.


Thioctic acid

A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.


A carbohydrate acid derivative anion that is the conjugate base of alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide arising from deprotonation of the neuraminosyl carboxy group; major species at pH 7.3.


3'-dUMP dianion

A 2'-deoxyribonucleoside 3'-monophosphate(2-) obtained by deprotonation of the phosphate OH groups of 2'-deoxyuridine 3'-monophosphate (3'-dUMP); major species at pH 7.3.


A sialodiosylceramide consisting of the tetrasaccharide alpha-Neu5NAc-(2->8)-alpha-Neu5NAc-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc attached to the primary hydroxy function of ceramide.


Uridine 2'-phosphate(2-)

A organophosphate oxoanion obtained by deprotonation of the phosphate OH groups of uridine 2'-phosphate. Major structure at pH 7.3 (according to Marvin v 6.2.0.).


An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of ganglioside GT3; major species at pH 7.3.


A nucleoside 3'-phosphate(2-) obtained by deprotonation of the phosphate OH groups of uridine 3'-monophosphate (UMP). It is the predominant species at physiological pH.


A dihexosylceramide sulfate(1-) obtained by deprotonation of the sulfate group of beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide; major species at pH 7.3.


An N-(long-chain-acyl)ethanolamine resulting from the formal condensation of the carboxy group of tetradecanoic acid (myristic acid) with the amino group of ethanolamine.


An N-(long-chain-acyl)ethanolamine resulting from the formal condensation of the carboxy group of dodecanoic acid (myristic acid) with the amino group of ethanolamine.


An N-acylethanolamine 18:0 that is the ethanolamide of octadecanoic acid.


An NADP obtained by formal reduction of the 1,2-position in the pyridine ring of beta-NAD.


An NADP obtained by formal reduction of the 1,6-position in the pyridine ring of beta-NAD.


PRP16_HUMAN Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (sprot)

A pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 that is encoded in the genome of human.


GDS1_HUMAN Rap1 GTPase-GDP dissociation stimulator 1 (sprot)

A Rap1 GTPase-GDP dissociation stimulator 1 that is encoded in the genome of human.


FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 (sprot)

A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human.


ARF1_HUMAN ADP-ribosylation factor 1 (sprot)

An ADP-ribosylation factor 1 that is encoded in the genome of human.


RN185_HUMAN E3 ubiquitin-protein ligase RNF185 (sprot)

An E3 ubiquitin-protein ligase RNF185 that is encoded in the genome of human.


KAT2B_HUMAN Histone acetyltransferase KAT2B (sprot)

A histone acetyltransferase KAT2B that is encoded in the genome of human.


S17A5_HUMAN Sialin (sprot)

A sialin that is encoded in the genome of human.


GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 2 that is encoded in the genome of human.


GALT4_HUMAN Polypeptide N-acetylgalactosaminyltransferase 4 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 4 that is encoded in the genome of human.


GALT1_HUMAN Polypeptide N-acetylgalactosaminyltransferase 1 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 1 that is encoded in the genome of human.


GALT3_HUMAN Polypeptide N-acetylgalactosaminyltransferase 3 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 3 that is encoded in the genome of human.


ZNT5_HUMAN Proton-coupled zinc antiporter SLC30A5 (sprot)

A proton-coupled zinc antiporter SLC30A5 that is encoded in the genome of human.


LGMN_HUMAN Legumain (sprot)

A legumain that is encoded in the genome of human.


SENP1_HUMAN Sentrin-specific protease 1 (sprot)

A sentrin-specific protease 1 that is encoded in the genome of human.


EXO1_HUMAN Exonuclease 1 (sprot)

An exonuclease 1 that is encoded in the genome of human.


heparan sulfate

A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.


KCJ11_HUMAN ATP-sensitive inward rectifier potassium channel 11 (sprot)

An ATP-sensitive inward rectifier potassium channel 11 that is encoded in the genome of human.


OGG1_HUMAN N-glycosylase/DNA lyase (sprot)

An N-glycosylase/DNA lyase that is encoded in the genome of human.


3MG_HUMAN DNA-3-methyladenine glycosylase (sprot)

A DNA-3-methyladenine glycosylase that is encoded in the genome of human.


NEIL1_HUMAN Endonuclease 8-like 1 (sprot)

An endonuclease 8-like 1 that is encoded in the genome of human.


NTH_HUMAN Endonuclease III-like protein 1 (sprot)

An endonuclease III-like protein 1 that is encoded in the genome of human.


MBD4_HUMAN Methyl-CpG-binding domain protein 4 (sprot)

A methyl-CpG-binding domain protein 4 that is encoded in the genome of human.


uracil-DNA glycosylase isoform h2 (human)

A uracil-DNA glycosylase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13051-1.


NEIL2_HUMAN Endonuclease 8-like 2 (sprot)

An endonuclease 8-like 2 that is encoded in the genome of human.


SMUG1_HUMAN Single-strand selective monofunctional uracil DNA glycosylase (sprot)

A single-strand selective monofunctional uracil DNA glycosylase that is encoded in the genome of human.


adenine DNA glycosylase isoform hAlpha-3 (human)

An adenine DNA glycosylase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UIF7-3.


CTDP1_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase (sprot)

An RNA polymerase II subunit A C-terminal domain phosphatase that is encoded in the genome of human.


ACRO_HUMAN Acrosin (sprot)

An acrosin that is encoded in the genome of human.


FACR2_HUMAN Fatty acyl-CoA reductase 2 (sprot)

A fatty acyl-CoA reductase 2 that is encoded in the genome of human.


FACR1_HUMAN Fatty acyl-CoA reductase 1 (sprot)

A fatty acyl-CoA reductase 1 that is encoded in the genome of human.


SOCS6_HUMAN Suppressor of cytokine signaling 6 (sprot)

A suppressor of cytokine signaling 6 that is encoded in the genome of human.


CRLS1_HUMAN Cardiolipin synthase (CMP-forming) (sprot)

A CMP-forming cardiolipin synthase that is encoded in the genome of human.


UBIA1_HUMAN UbiA prenyltransferase domain-containing protein 1 (sprot)

A UbiA prenyltransferase domain-containing protein 1 that is encoded in the genome of human.


S27A5_HUMAN Long-chain fatty acid transport protein 5 (sprot)

A long-chain fatty acid transport protein 5 that is encoded in the genome of human.


PIGA_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (sprot)

An N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein that is encoded in the genome of human.


PIGL_HUMAN N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (sprot)

An N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase that is encoded in the genome of human.


PIGW_HUMAN Phosphatidylinositol-glycan biosynthesis class W protein (sprot)

A phosphatidylinositol-glycan biosynthesis class W protein that is encoded in the genome of human.


GLR_HUMAN Glucagon receptor (sprot)

A glucagon receptor that is encoded in the genome of human.


SUMF1_HUMAN Formylglycine-generating enzyme (sprot)

A formylglycine-generating enzyme that is encoded in the genome of human.


PPM1L_HUMAN Protein phosphatase 1L (sprot)

A protein phosphatase 1L that is encoded in the genome of human.


P2Y12_HUMAN P2Y purinoceptor 12 (sprot)

A P2Y purinoceptor 12 that is encoded in the genome of human.


DNA2_HUMAN DNA replication ATP-dependent helicase/nuclease DNA2 (sprot)

A DNA replication ATP-dependent helicase/nuclease DNA2 that is encoded in the genome of human.


SUIS_HUMAN Sucrase-isomaltase, intestinal (sprot)

A sucrase-isomaltase, intestinal that is encoded in the genome of human.


feline leukemia virus subgroup C receptor-related protein 1 isoform h2 (human)

A feline leukemia virus subgroup C receptor-related protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5Y0-2.


proto-oncogene tyrosine-protein kinase Src isoform 2 (human)

A proto-oncogene tyrosine-protein kinase Src isoform 2 that is encoded in the genome of human.


CP27A_HUMAN Sterol 26-hydroxylase, mitochondrial (sprot)

A cytochrome P450 27, mitochondrial that is encoded in the genome of human.


3BHS7_HUMAN 3 beta-hydroxysteroid dehydrogenase type 7 (sprot)

A 3 beta-hydroxysteroid dehydrogenase type 7 that is encoded in the genome of human.


CP11A_HUMAN Cholesterol side-chain cleavage enzyme, mitochondrial (sprot)

A cytochrome P450 11A1, mitochondrial that is encoded in the genome of human.


AMACR_HUMAN Alpha-methylacyl-CoA racemase (sprot)

An alpha-methylacyl-CoA racemase that is encoded in the genome of human.


SC5D_HUMAN Lathosterol oxidase (sprot)

A lathosterol oxidase that is encoded in the genome of human.


CP27B_HUMAN 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (sprot)

A 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial that is encoded in the genome of human.


CP2R1_HUMAN Vitamin D 25-hydroxylase (sprot)

A vitamin D 25-hydroxylase that is encoded in the genome of human.


S35A2_HUMAN UDP-galactose translocator (sprot)

A UDP-galactose translocator that is encoded in the genome of human.


B3GT6_HUMAN Beta-1,3-galactosyltransferase 6 (sprot)

A beta-1,3-galactosyltransferase 6 that is encoded in the genome of human.


CP7A1_HUMAN Cytochrome P450 7A1 (sprot)

A cytochrome P450 7A1 that is encoded in the genome of human.


GBF1_HUMAN Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (sprot)

A Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 that is encoded in the genome of human.


An N-acetylglucosamine-6-sulfatase that is encoded in the genome of human.


S35A3_HUMAN UDP-N-acetylglucosamine transporter (sprot)

A UDP-N-acetylglucosamine transporter that is encoded in the genome of human.


TIE2_HUMAN Angiopoietin-1 receptor (sprot)

An angiopoietin-1 receptor that is encoded in the genome of human.


CP2S1_HUMAN Cytochrome P450 2S1 (sprot)

A cytochrome P450 2S1 that is encoded in the genome of human.


RET3_HUMAN Retinol-binding protein 3 (sprot)

A retinol-binding protein 3 that is encoded in the genome of human.


RDH12_HUMAN Retinol dehydrogenase 12 (sprot)

A retinol dehydrogenase 12 that is encoded in the genome of human.


IGF1R_HUMAN Insulin-like growth factor 1 receptor (sprot)

An insulin-like growth factor 1 receptor that is encoded in the genome of human.


ABCA4_HUMAN Retinal-specific phospholipid-transporting ATPase ABCA4 (sprot)

A retinal-specific phospholipid-transporting ATPase ABCA4 that is encoded in the genome of human.


GRK1_HUMAN Rhodopsin kinase GRK1 (sprot)

A rhodopsin kinase GRK1 that is encoded in the genome of human.


MYO5A_HUMAN Unconventional myosin-Va (sprot)

A myosin-Va that is encoded in the genome of human.


ZNT8_HUMAN Proton-coupled zinc antiporter SLC30A8 (sprot)

A proton-coupled zinc antiporter SLC30A8 that is encoded in the genome of human.


SAE2_HUMAN SUMO-activating enzyme subunit 2 (sprot)

A SUMO-activating enzyme subunit 2 that is encoded in the genome of human.


ANM6_HUMAN Protein arginine N-methyltransferase 6 (sprot)

A protein arginine N-methyltransferase 6 that is encoded in the genome of human.


PORCN_HUMAN Protein-serine O-palmitoleoyltransferase porcupine (sprot)

A protein-serine O-palmitoleoyltransferase porcupine that is encoded in the genome of human.


ATP7A_HUMAN Copper-transporting ATPase 1 (sprot)

A copper-transporting ATPase 1 that is encoded in the genome of human.


SYVN1_HUMAN E3 ubiquitin-protein ligase synoviolin (sprot)

An E3 ubiquitin-protein ligase synoviolin that is encoded in the genome of human.


EDEM1_HUMAN ER degradation-enhancing alpha-mannosidase-like protein 1 (sprot)

An ER degradation-enhancing alpha-mannosidase-like protein 1 that is encoded in the genome of human.


PM34_HUMAN Peroxisomal membrane protein PMP34 (sprot)

A peroxisomal membrane protein PMP34 that is encoded in the genome of human.


LIPT2_HUMAN Putative lipoyltransferase 2, mitochondrial (sprot)

A putative lipoyltransferase 2, mitochondrial that is encoded in the genome of human.


ECHP_HUMAN Peroxisomal bifunctional enzyme (sprot)

A peroxisomal bifunctional enzyme that is encoded in the genome of human.


NEUR1_HUMAN Sialidase-1 (sprot)

A sialidase-1 that is encoded in the genome of human.


DOPP1_HUMAN Dolichyldiphosphatase 1 (sprot)

A dolichyldiphosphatase 1 that is encoded in the genome of human.


CSF1R_HUMAN Macrophage colony-stimulating factor 1 receptor (sprot)

A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of human.


LAAT1_HUMAN Lysosomal amino acid transporter 1 homolog (sprot)

A lysosomal amino acid transporter 1 homolog that is encoded in the genome of human.


PMS2_HUMAN Mismatch repair endonuclease PMS2 (sprot)

A mismatch repair endonuclease PMS2 that is encoded in the genome of human.


FMT_HUMAN Methionyl-tRNA formyltransferase, mitochondrial (sprot)

A methionyl-tRNA formyltransferase, mitochondrial that is encoded in the genome of human.


CP2AD_HUMAN Cytochrome P450 2A13 (sprot)

A cytochrome P450 2A that is a translation product of the CYP2A13 gene in human.


KDM4C_HUMAN Lysine-specific demethylase 4C (sprot)

A lysine-specific demethylase 4C that is encoded in the genome of human.


KDM6A_HUMAN Lysine-specific demethylase 6A (sprot)

A lysine-specific demethylase 6A that is encoded in the genome of human.


PNKP_HUMAN Bifunctional polynucleotide phosphatase/kinase (sprot)

A bifunctional polynucleotide phosphatase/kinase that is encoded in the genome of human.


UBP30_HUMAN Ubiquitin carboxyl-terminal hydrolase 30 (sprot)

A ubiquitin carboxyl-terminal hydrolase 30 that is encoded in the genome of human.


UBP45_HUMAN Ubiquitin carboxyl-terminal hydrolase 45 (sprot)

A ubiquitin carboxyl-terminal hydrolase 45 that is encoded in the genome of human.


TRM5_HUMAN tRNA (guanine(37)-N1)-methyltransferase (sprot)

A tRNA (guanine-N(1)-)-methyltransferase that is encoded in the genome of human.


GCST_HUMAN Aminomethyltransferase, mitochondrial (sprot)

An aminomethyltransferase, mitochondrial that is encoded in the genome of human.


EXOSX_HUMAN Exosome component 10 (sprot)

An exosome component 10 that is encoded in the genome of human.


XRN2_HUMAN 5'-3' exoribonuclease 2 (sprot)

A 5'-3' exoribonuclease 2 that is encoded in the genome of human.


AL7A1_HUMAN Alpha-aminoadipic semialdehyde dehydrogenase (sprot)

An alpha-aminoadipic semialdehyde dehydrogenase that is encoded in the genome of human.


CHDH_HUMAN Choline dehydrogenase, mitochondrial (sprot)

A choline dehydrogenase, mitochondrial that is encoded in the genome of human.


PP4P1_HUMAN Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (sprot)

A type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase that is encoded in the genome of human.


RHBT3_HUMAN Rho-related BTB domain-containing protein 3 (sprot)

A Rho-related BTB domain-containing protein 3 that is encoded in the genome of human.


LCMT1_HUMAN Leucine carboxyl methyltransferase 1 (sprot)

A leucine carboxyl methyltransferase 1 that is encoded in the genome of human.


PROD_HUMAN Proline dehydrogenase 1, mitochondrial (sprot)

A proline dehydrogenase 1, mitochondrial that is encoded in the genome of human.


HYPDH_HUMAN Hydroxyproline dehydrogenase (sprot)

A hydroxyproline dehydrogenase that is encoded in the genome of human.


NAGS_HUMAN N-acetylglutamate synthase, mitochondrial (sprot)

An N-acetylglutamate synthase, mitochondrial that is encoded in the genome of human.


SOX_HUMAN Peroxisomal sarcosine oxidase (sprot)

A peroxisomal sarcosine oxidase that is encoded in the genome of human.


CRYM_HUMAN Ketimine reductase mu-crystallin (sprot)

A ketimine reductase mu-crystallin that is encoded in the genome of human.


S2544_HUMAN Solute carrier family 25 member 44 (sprot)

A solute carrier family 25 member 44 that is encoded in the genome of human.


DDX46_HUMAN Probable ATP-dependent RNA helicase DDX46 (sprot)

A probable ATP-dependent RNA helicase DDX46 that is encoded in the genome of human.


DDX23_HUMAN Probable ATP-dependent RNA helicase DDX23 (sprot)

A probable ATP-dependent RNA helicase DDX23 that is encoded in the genome of human.


U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (sprot)

A U5 small nuclear ribonucleoprotein 200 kDa helicase that is encoded in the genome of human.


ACSS3_HUMAN Acyl-CoA synthetase short-chain family member 3, mitochondrial (sprot)

An acyl-CoA synthetase short-chain family member 3, mitochondrial that is encoded in the genome of human.


MTP_HUMAN Microsomal triglyceride transfer protein large subunit (sprot)

A microsomal triglyceride transfer protein large subunit that is encoded in the genome of human.


KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (sprot)

A histone-lysine N-methyltransferase 2A that is encoded in the genome of human.


NCEH1_HUMAN Neutral cholesterol ester hydrolase 1 (sprot)

A neutral cholesterol ester hydrolase 1 that is encoded in the genome of human.


NAT8L_HUMAN N-acetylaspartate synthetase (sprot)

An N-acetylaspartate synthetase that is encoded in the genome of human.


LCAT_HUMAN Phosphatidylcholine-sterol acyltransferase (sprot)

A phosphatidylcholine-sterol acyltransferase that is encoded in the genome of human.


LICH_HUMAN Lysosomal acid lipase/cholesteryl ester hydrolase (sprot)

A lysosomal acid lipase/cholesteryl ester hydrolase that is encoded in the genome of human.


RHOU_HUMAN Rho-related GTP-binding protein RhoU (sprot)

A Rho-related GTP-binding protein RhoU that is encoded in the genome of human.


FUT1_HUMAN Galactoside alpha-(1,2)-fucosyltransferase 1 (sprot)

A galactoside alpha-(1,2)-fucosyltransferase 1 that is encoded in the genome of human.


CERU_HUMAN Ceruloplasmin (sprot)

A ceruloplasmin that is encoded in the genome of human.


AGRG6_HUMAN Adhesion G-protein coupled receptor G6 (sprot)

An adhesion G-protein coupled receptor G6 that is encoded in the genome of human.


SCN3A_HUMAN Sodium channel protein type 3 subunit alpha (sprot)

A sodium channel protein type 3 subunit alpha that is encoded in the genome of human.


SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (sprot)

A sodium channel protein type 9 subunit alpha that is encoded in the genome of human.


SCN2A_HUMAN Sodium channel protein type 2 subunit alpha (sprot)

A sodium channel protein type 2 subunit alpha that is encoded in the genome of human.


An alpha-(1,6)-fucosyltransferase that is encoded in the genome of human.


TCO1_HUMAN Transcobalamin-1 (sprot)

A transcobalamin-1 that is encoded in the genome of human.


TCO2_HUMAN Transcobalamin-2 (sprot)

A transcobalamin-2 that is encoded in the genome of human.


MMAB_HUMAN Corrinoid adenosyltransferase MMAB (sprot)

A corrinoid adenosyltransferase MMAB that is encoded in the genome of human.


BACE1_HUMAN Beta-secretase 1 (sprot)

A beta-secretase 1 that is encoded in the genome of human.


DX39A_HUMAN ATP-dependent RNA helicase DDX39A (sprot)

An ATP-dependent RNA helicase DDX39 that is encoded in the genome of human.


RN103_HUMAN E3 ubiquitin-protein ligase RNF103 (sprot)

An E3 ubiquitin-protein ligase RNF103 that is encoded in the genome of human.


H17B6_HUMAN 17-beta-hydroxysteroid dehydrogenase type 6 (sprot)

A 17-beta-hydroxysteroid dehydrogenase type 6 that is encoded in the genome of human.


ATS3_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 3 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 3 that is encoded in the genome of human.


MARH6_HUMAN E3 ubiquitin-protein ligase MARCHF6 (sprot)

An E3 ubiquitin-protein ligase MARCHF6 that is encoded in the genome of human.


TPST1_HUMAN Protein-tyrosine sulfotransferase 1 (sprot)

A protein-tyrosine sulfotransferase 1 that is encoded in the genome of human.


TPST2_HUMAN Protein-tyrosine sulfotransferase 2 (sprot)

A protein-tyrosine sulfotransferase 2 that is encoded in the genome of human.


TRI13_HUMAN E3 ubiquitin-protein ligase TRIM13 (sprot)

An E3 ubiquitin-protein ligase TRIM13 that is encoded in the genome of human.


RDH16_HUMAN Retinol dehydrogenase 16 (sprot)

A retinol dehydrogenase 16 that is encoded in the genome of human.


CP7B1_HUMAN Cytochrome P450 7B1 (sprot)

A cytochrome P450 7B1 that is encoded in the genome of human.


ATS2_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 2 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 2 that is encoded in the genome of human.


NAPSA_HUMAN Napsin-A (sprot)

A napsin-A that is encoded in the genome of human.


AMYP_HUMAN Pancreatic alpha-amylase (sprot)

An alpha-amylase 2A that is encoded in the genome of human.


CATL1_HUMAN Procathepsin L (sprot)

A procathepsin L that is encoded in the genome of human.


CATH_HUMAN Pro-cathepsin H (sprot)

A cathepsin H that is encoded in the genome of human.


PEPA4_HUMAN Pepsin A-4 (sprot)

A pepsin A-4 that is encoded in the genome of human.


PEPA3_HUMAN Pepsin A-3 (sprot)

A pepsin A-3 that is encoded in the genome of human.


PEPA5_HUMAN Pepsin A-5 (sprot)

A pepsin A-5 that is encoded in the genome of human.


AMY1B_HUMAN Alpha-amylase 1B (sprot)

A protein that is a translation product of the AMY1B gene in human.


AMY1C_HUMAN Alpha-amylase 1C (sprot)

A protein that is a translation product of the AMY1C gene in human.


AMY1A_HUMAN Alpha-amylase 1A (sprot)

A protein that is a translation product of the AMY1A gene in human.


PPGB_HUMAN Lysosomal protective protein (sprot)

A lysosomal protective protein that is encoded in the genome of human.


CP2A6_HUMAN Cytochrome P450 2A6 (sprot)

A cytochrome P450 2A that is a translation product of the CYP2A6 gene in human.


CATE_HUMAN Cathepsin E (sprot)

A cathepsin E that is encoded in the genome of human.


AMY2B_HUMAN Alpha-amylase 2B (sprot)

An alpha-amylase 2B that is encoded in the genome of human.


CP2B6_HUMAN Cytochrome P450 2B6 (sprot)

A cytochrome P450 2B6 that is encoded in the genome of human.


CP3A5_HUMAN Cytochrome P450 3A5 (sprot)

A cytochrome P450 3A5 that is encoded in the genome of human.


CP2A7_HUMAN Cytochrome P450 2A7 (sprot)

A cytochrome P450 2A that is a translation product of the CYP2A7 gene in human.


CP2F1_HUMAN Cytochrome P450 2F1 (sprot)

A cytochrome P450 2F1 that is encoded in the genome of human.


HMOX2_HUMAN Heme oxygenase 2 (sprot)

A heme oxygenase 2 that is encoded in the genome of human.


G protein-coupled receptor kinase 4 isoform h1 (human)

A G protein-coupled receptor kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32298-1.


TRY3_HUMAN Trypsin-3 (sprot)

A trypsin-3 that is encoded in the genome of human.


CATO_HUMAN Cathepsin O (sprot)

A cathepsin O that is encoded in the genome of human.


GRK6_HUMAN G protein-coupled receptor kinase 6 (sprot)

A G protein-coupled receptor kinase 6 that is encoded in the genome of human.


VDAC2_HUMAN Voltage-dependent anion-selective channel protein 2 (sprot)

A voltage-dependent anion-selective channel protein 2 that is encoded in the genome of human.


GUC2F_HUMAN Retinal guanylyl cyclase 2 (sprot)

A retinal guanylyl cyclase 2 that is encoded in the genome of human.


CATC_HUMAN Dipeptidyl peptidase 1 (sprot)

A dipeptidyl peptidase 1 that is encoded in the genome of human.


ARF3_HUMAN ADP-ribosylation factor 3 (sprot)

An ADP-ribosylation factor 3 that is encoded in the genome of human.


ARF5_HUMAN ADP-ribosylation factor 5 (sprot)

An ADP-ribosylation factor 5 that is encoded in the genome of human.


GUC2D_HUMAN Retinal guanylyl cyclase 1 (sprot)

A retinal guanylyl cyclase 1 that is encoded in the genome of human.


GLTL6_HUMAN Polypeptide N-acetylgalactosaminyltransferase-like 6 (sprot)

A polypeptide N-acetylgalactosaminyltransferase-like 6 that is encoded in the genome of human.


ACSM3_HUMAN Acyl-coenzyme A synthetase ACSM3, mitochondrial (sprot)

An acyl-coenzyme A synthetase ACSM3, mitochondrial that is encoded in the genome of human.


ESCO2_HUMAN N-acetyltransferase ESCO2 (sprot)

An N-acetyltransferase ESCO2 that is encoded in the genome of human.


ESCO1_HUMAN N-acetyltransferase ESCO1 (sprot)

An N-acetyltransferase ESCO1 that is encoded in the genome of human.


GLT17_HUMAN Polypeptide N-acetylgalactosaminyltransferase 17 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 17 that is encoded in the genome of human.


ACSM6_HUMAN Acyl-coenzyme A synthetase ACSM6, mitochondrial (sprot)

An acyl-coenzyme A synthetase ACSM6, mitochondrial that is encoded in the genome of human.


GLT18_HUMAN Polypeptide N-acetylgalactosaminyltransferase 18 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 18 that is encoded in the genome of human.


GLTL5_HUMAN Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 (sprot)

A polypeptide N-acetylgalactosaminyltransferase-like protein 5 that is encoded in the genome of human.


GALT5_HUMAN Polypeptide N-acetylgalactosaminyltransferase 5 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 5 that is encoded in the genome of human.


GALT7_HUMAN N-acetylgalactosaminyltransferase 7 (sprot)

An N-acetylgalactosaminyltransferase 7 that is encoded in the genome of human.


GLT10_HUMAN Polypeptide N-acetylgalactosaminyltransferase 10 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 10 that is encoded in the genome of human.


GLT13_HUMAN Polypeptide N-acetylgalactosaminyltransferase 13 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 13 that is encoded in the genome of human.


GLT12_HUMAN Polypeptide N-acetylgalactosaminyltransferase 12 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 12 that is encoded in the genome of human.


RDH10_HUMAN Retinol dehydrogenase 10 (sprot)

A retinol dehydrogenase 10 that is encoded in the genome of human.


PELI3_HUMAN E3 ubiquitin-protein ligase pellino homolog 3 (sprot)

An E3 ubiquitin-protein ligase pellino homolog 3 that is encoded in the genome of human.


GLT15_HUMAN Polypeptide N-acetylgalactosaminyltransferase 15 (sprot)

A polypeptide N-acetylgalactosaminyltransferase-like protein 2 that is encoded in the genome of human.


RDHE2_HUMAN Epidermal retinol dehydrogenase 2 (sprot)

An epidermal retinol dehydrogenase 2 that is encoded in the genome of human.


GLT16_HUMAN Polypeptide N-acetylgalactosaminyltransferase 16 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 16 that is encoded in the genome of human.


GALT6_HUMAN Polypeptide N-acetylgalactosaminyltransferase 6 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 6 that is encoded in the genome of human.


GLT11_HUMAN Polypeptide N-acetylgalactosaminyltransferase 11 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 11 that is encoded in the genome of human.


DR9C7_HUMAN Short-chain dehydrogenase/reductase family 9C member 7 (sprot)

A short-chain dehydrogenase/reductase family 9C member 7 that is encoded in the genome of human.


S35B2_HUMAN Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (sprot)

An adenosine 3'-phospho 5'-phosphosulfate transporter 1 that is encoded in the genome of human.


GRK7_HUMAN Rhodopsin kinase GRK7 (sprot)

A rhodopsin kinase GRK7 that is encoded in the genome of human.


SETD7_HUMAN Histone-lysine N-methyltransferase SETD7 (sprot)

A histone-lysine N-methyltransferase SETD7 that is encoded in the genome of human.


RN139_HUMAN E3 ubiquitin-protein ligase RNF139 (sprot)

An E3 ubiquitin-protein ligase RNF139 that is encoded in the genome of human.


ATS14_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 14 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 14 that is encoded in the genome of human.


RDH5_HUMAN Retinol dehydrogenase 5 (sprot)

A retinol dehydrogenase 5 that is encoded in the genome of human.


MFRN2_HUMAN Mitoferrin-2 (sprot)

A mitoferrin-2 that is encoded in the genome of human.


GLT14_HUMAN Polypeptide N-acetylgalactosaminyltransferase 14 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 14 that is encoded in the genome of human.


SENP5_HUMAN Sentrin-specific protease 5 (sprot)

A sentrin-specific protease 5 that is encoded in the genome of human.


RNF5_HUMAN E3 ubiquitin-protein ligase RNF5 (sprot)

An E3 ubiquitin-protein ligase RNF5 that is encoded in the genome of human.


DHRS9_HUMAN Dehydrogenase/reductase SDR family member 9 (sprot)

A dehydrogenase/reductase SDR family member 9 that is encoded in the genome of human.


EDEM2_HUMAN ER degradation-enhancing alpha-mannosidase-like protein 2 (sprot)

An ER degradation-enhancing alpha-mannosidase-like protein 2 that is encoded in the genome of human.


EDEM3_HUMAN ER degradation-enhancing alpha-mannosidase-like protein 3 (sprot)

An ER degradation-enhancing alpha-mannosidase-like protein 3 that is encoded in the genome of human.


S35B3_HUMAN Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (sprot)

An adenosine 3'-phospho 5'-phosphosulfate transporter 2 that is encoded in the genome of human.


PELI2_HUMAN E3 ubiquitin-protein ligase pellino homolog 2 (sprot)

An E3 ubiquitin-protein ligase pellino homolog 2 that is encoded in the genome of human.


SENP2_HUMAN Sentrin-specific protease 2 (sprot)

A sentrin-specific protease 2 that is encoded in the genome of human.


GALT9_HUMAN Polypeptide N-acetylgalactosaminyltransferase 9 (sprot)

A polypeptide N-acetylgalactosaminyltransferase 9 that is encoded in the genome of human.


ANM7_HUMAN Protein arginine N-methyltransferase 7 (sprot)

A protein arginine N-methyltransferase 7 that is encoded in the genome of human.


GALT8_HUMAN Probable polypeptide N-acetylgalactosaminyltransferase 8 (sprot)

A probable polypeptide N-acetylgalactosaminyltransferase 8 that is encoded in the genome of human.


UGGG2_HUMAN UDP-glucose:glycoprotein glucosyltransferase 2 (sprot)

A UDP-glucose:glycoprotein glucosyltransferase 2 that is encoded in the genome of human.


UGGG1_HUMAN UDP-glucose:glycoprotein glucosyltransferase 1 (sprot)

A UDP-glucose:glycoprotein glucosyltransferase 1 that is encoded in the genome of human.


MFRN1_HUMAN Mitoferrin-1 (sprot)

A mitoferrin-1 that is encoded in the genome of human.


CATF_HUMAN Cathepsin F (sprot)

A cathepsin F that is encoded in the genome of human.


MA1B1_HUMAN Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (sprot)

An endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase that is encoded in the genome of human.


VDAC3_HUMAN Voltage-dependent anion-selective channel protein 3 (sprot)

A voltage-dependent anion-selective channel protein 3 that is encoded in the genome of human.


positive regulation of oogenesis

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that activates or increases the frequency, rate or extent of oogenesis.


cytoplasmic capsid assembly

The assembly of a virus capsid that occurs in the cytoplasm.


suppression by virus of host mRNA splicing

Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production.


ribosomal large subunit assembly

The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.


ribosomal large subunit biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.


maturation of LSU-rRNA

Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.


negative regulation of mRNA 3'-end processing

Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing.


translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


evasion of host immune response

A process by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


ribosome disassembly

The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.


non-membrane-bounded organelle assembly

The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.


cholesterol 25-hydroxylase activity

Catalysis of the reaction: AH(2) + cholesterol + O2 = 25-hydroxycholesterol + A + H2O.


host cell surface receptor binding

Binding to a receptor on the host cell surface.


cholesterol O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA.


endoplasmic reticulum-Golgi intermediate compartment

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.


paraspeckles

Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.


mRNA cleavage and polyadenylation specificity factor complex

A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.


cytosolic large ribosomal subunit

The large subunit of a ribosome located in the cytosol.


PSPC1_HUMAN Paraspeckle component 1 (sprot)

A paraspeckle component 1 that is encoded in the genome of human.


THIL_HUMAN Acetyl-CoA acetyltransferase, mitochondrial (sprot)

An acetyl-CoA acetyltransferase, mitochondrial that is encoded in the genome of human.


CH25H_HUMAN Cholesterol 25-hydroxylase (sprot)

A cholesterol 25-hydroxylase that is encoded in the genome of human.


autosome genomic imprinting

The establishment of epigenetic modifications (imprints) in autosomal (non-sexual) chromosomes during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation.


positive regulation of oocyte development

Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.


ovulation

The release of a mature ovum/oocyte from an ovary.


maternal-to-zygotic transition of gene expression

Any process that modulates the frequency, rate or extent of gene expression by which developmental control passes from the maternal genome to the zygotic genome.


positive regulation of cellular response to heat

Any process that activates or increases the frequency, rate or extent of cellular response to heat.


cytoplasmic translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


IF5_HUMAN Eukaryotic translation initiation factor 5 (sprot)

A eukaryotic translation initiation factor 5 that is encoded in the genome of human.


IF4G3_HUMAN Eukaryotic translation initiation factor 4 gamma 3 (sprot)

A eukaryotic translation initiation factor 4 gamma 3 that is encoded in the genome of human.


IF4A1_HUMAN Eukaryotic initiation factor 4A-I (sprot)

A eukaryotic initiation factor 4A-I that is encoded in the genome of human.


The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.


E2AK3_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 3 (sprot)

A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of human.


GCN1_HUMAN Stalled ribosome sensor GCN1 (sprot)

An eIF-2-alpha kinase activator GCN1 that is encoded in the genome of human.


OMA1_HUMAN Metalloendopeptidase OMA1, mitochondrial (sprot)

A metalloendopeptidase OMA1, mitochondrial that is encoded in the genome of human.


cannabinoid receptor activity

Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.


retrograde trans-synaptic signaling by endocannabinoid

Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand.


regulation of ATP metabolic process

Any process that modulates the frequency, rate or extent of ATP metabolic process.


receptor complex

Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.


ribonucleoprotein complex

A macromolecular complex that contains both RNA and protein molecules.


nuclear inclusion body

An intranuclear focus at which aggregated proteins have been sequestered.


protein phosphatase type 2A complex

A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.


AMPA glutamate receptor complex

An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.


G protein-coupled receptor dimeric complex

A protein complex that contains two G protein-coupled receptors.


lysophosphatidic acid acyltransferase activity

Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid.


protein deubiquitination

The removal of one or more ubiquitin groups from a protein.


carbohydrate phosphorylation

The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.


neuronal stem cell division

The self-renewing division of a neuronal stem cell.


protein localization to organelle

A process in which a protein is transported to, or maintained in, a location within an organelle.


ventricular system development

The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.


receptor localization to non-motile cilium

A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium.


synaptic vesicle membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle.


intracellular chloride ion homeostasis

A homeostatic process involved in the maintenance of a steady state level of chloride ions within a cell.


protein N-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.


regulation of sphingolipid biosynthetic process

Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


negative regulation of serine C-palmitoyltransferase activity

Any process that stops, prevents or reduces the frequency, rate or extent of serine C-palmitoyltransferase activity.


regulation of ceramide biosynthetic process

Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process.


very long-chain fatty acid metabolic process

The chemical reactions and pathways involving a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons.


nuclear membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.


PDZ domain binding

Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.


proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.


tryptophan metabolic process

The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.


pumilio-response element binding

Binding to a region of RNA containing a Pumilio-response element element. The consensus sequence for the element is UGUAAAUA.


synaptic transmission, serotonergic

The vesicular release of serotonin from a presynapse, across a chemical synapse, the subsequent activation of serotonin receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


mitochondrial ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.


regulation of protein localization to plasma membrane

Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.


neutral lipid metabolic process

The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.


glycine transmembrane transporter activity

Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid.


regulation of autophagy

Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


arachidonic acid binding

Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.


response to reactive oxygen species

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.


gamma-aminobutyric acid metabolic process

The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.


lateral ventricle development

The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.


biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.


positive regulation of myelination

Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.


regulation of respiratory gaseous exchange by nervous system process

A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.


regulation of synaptic transmission, glutamatergic

Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.


prepulse inhibition

The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse.


negative regulation of epithelial cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.


protein phosphatase binding

Binding to a protein phosphatase.


positive regulation of neural precursor cell proliferation

Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.


pteridine metabolic process

The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group.


beta-tubulin binding

Binding to the microtubule constituent protein beta-tubulin.


interleukin-17 production

The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


negative regulation of hydrolase activity

Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.


corpus callosum morphogenesis

The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres.


negative regulation of protein localization to centrosome

Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome.


corticospinal tract morphogenesis

Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.


membrane protein ectodomain proteolysis

The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


positive regulation of mRNA splicing, via spliceosome

Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.


locomotion involved in locomotory behavior

Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.


maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.


phosphatidylinositol metabolic process

The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.


neuronal stem cell population maintenance

Any process in by an organism or tissue maintains a population of neuronal stem cells.


regulation of actin cytoskeleton organization

Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.


release of cytochrome c from mitochondria

The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.


glycine transport

The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


choline transport

The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.


acyl-CoA biosynthetic process

The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.


interkinetic nuclear migration

The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle.


neurexin family protein binding

Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.


positive regulation of dendritic spine development

Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


inositol metabolic process

The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.


ganglioside biosynthetic process

The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.


short-term memory

The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.


positive regulation of receptor binding

Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.


Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage.


serine hydrolase activity

Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


proteasome core complex assembly

The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles.


leukocyte migration involved in inflammatory response

The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.