regulation of definitive erythrocyte differentiation

Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis.


proton-dependent oligopeptide secondary active transmembrane transporter activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.


oligopeptide transport

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


netrin receptor activity

Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


aromatic amino acid metabolic process

The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).


positive regulation of microglial cell activation

Any process that activates or increases the frequency, rate or extent of microglial cell activation.


SHQ1_HUMAN Protein SHQ1 homolog (sprot)

A protein SHQ1 that is encoded in the genome of human.


GAR1_HUMAN H/ACA ribonucleoprotein complex subunit 1 (sprot)

An H/ACA ribonucleoprotein complex subunit 1 that is encoded in the genome of human.


DKC1_HUMAN H/ACA ribonucleoprotein complex subunit DKC1 (sprot)

An H/ACA ribonucleoprotein complex catalytic subunit that is encoded in the genome of human.


NOP10_HUMAN H/ACA ribonucleoprotein complex subunit 3 (sprot)

An H/ACA ribonucleoprotein complex subunit 3 that is encoded in the genome of human.


TCAB1_HUMAN Telomerase Cajal body protein 1 (sprot)

A telomerase Cajal body protein 1 that is encoded in the genome of human.


NHP2_HUMAN H/ACA ribonucleoprotein complex subunit 2 (sprot)

An H/ACA ribonucleoprotein complex subunit 2 that is encoded in the genome of human.


regulation of acetylcholine secretion, neurotransmission

Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine.


musculoskeletal movement, spinal reflex action

Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord.


rhythmic synaptic transmission

Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit.


sigma non-opioid intracellular receptor 1 isoform 1 (mouse)

A sigma non-opioid intracellular receptor 1 isoform 1 that is encoded in the genome of mouse.


thyrotropin-releasing hormone activity

The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


1-Myristoyl-sn-glycerol 3-phosphate

A 1-acyl-sn-glycerol 3-phosphate having myristoyl (tetradecanoyl) as the 1-O-acyl group.


A 1-monoglyceride with tetradecanoyl (myristoyl) as the acyl group.


heparan sulfate binding

Binding to heparan sulfate.


negative regulation of odontogenesis of dentin-containing tooth

Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx.


A  3-acyl-sn-glycerol where arachidonoyl is the 3-acyl group.


postsynaptic specialization membrane of symmetric synapse

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The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.


G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential.


G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential

G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential.


regulation of presynapse organization

Any process that modulates the physical form of a presynapse.


MDGA1_HUMAN MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (sprot)

A MAM domain-containing glycosylphosphatidylinositol anchor protein 1 that is encoded in the genome of human.


dendrite regeneration

The regrowth of dendrites in response to their loss or damage.


eukaryotic translation elongation factor 1 complex

A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.


aryl hydrocarbon receptor complex

A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR.


type IV hypersensitivity

An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.


glucose catabolic process

The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.


positive regulation by symbiont of host apoptotic process

Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction.


FGF7_MOUSE Fibroblast growth factor 7 (sprot)

A fibroblast growth factor 7 that is encoded in the genome of mouse.


FGF22_MOUSE Fibroblast growth factor 22 (sprot)

A fibroblast growth factor 22 that is encoded in the genome of mouse.


FGF10_MOUSE Fibroblast growth factor 10 (sprot)

A fibroblast growth factor 10 that is encoded in the genome of mouse.


Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform m2 Src-phosphorylated form (mouse)

An Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform m2 (mouse) that has been phosphorylated on Tyr residues within Src phosphorylation sites. Example: UniProtKB:Q9QWY8-2, Tyr-782, MOD:00048.


NOTO_HUMAN Homeobox protein notochord (sprot)

A homeobox protein notochord that is encoded in the genome of human.


translation regulator activity

Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.


negative regulation of binding

Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.


negative regulation of bile acid biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


labyrinthine layer morphogenesis

The process in which the labyrinthine layer of the placenta is generated and organized.


carbon dioxide transport

The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


nuclear androgen receptor binding

Binding to a nuclear androgen receptor.


negative regulation of bone trabecula formation

Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation.


FasL biosynthetic process

The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines.


lymphocyte chemotaxis

The directed movement of a lymphocyte in response to an external stimulus.


urinary bladder smooth muscle contraction

A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.


regulation of skeletal muscle contraction by calcium ion signaling

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Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction.


B cell negative selection

Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.


response to mycotoxin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi.


positive regulation of calcium ion transport into cytosol

Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.


negative regulation of double-strand break repair via single-strand annealing

Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via single-strand annealing.


8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar.


oxidized base lesion DNA N-glycosylase activity

Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.


An oxopurine that is guanine which is substituted by an oxo group at position 8.


An azaspiro compound that is 1,3,6,8-tetraazaspiro[4.4]non-6-ene which is substituted by oxo groups at positions 2, 4, and 9. Both enantiomers are highly mutagenic products resulting from the oxidation of guanine and 8-oxo-7,8-dihydroguanine in DNA by reactive oxygen species.


Guanidinohydantoin

An imidazolidine-2,4-dione substituted by a guanidino group at position 5.


regulation of protein deacetylation

Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


creatine biosynthetic process

The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.


macrophage derived foam cell differentiation

The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


insemination

The introduction of semen or sperm into the genital tract of a female.


regulation of vascular associated smooth muscle contraction

Any process that increases the frequency, rate or extent of vascular smooth muscle contraction.


Q3V365_MOUSE Kinesin-like protein (trembl)

A kinesin-like protein KIF17 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3V365.


negative regulation of integrin activation

Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation.


anterograde dendritic transport of messenger ribonucleoprotein complex

The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse.


mitocytosis

A migrasome-mediated selective removal of damaged mitochondria process that maintains mitochondrion homeostasis in migrating cells.


regulation of sphingolipid mediated signaling pathway

Any process that modulates the frequency, rate or extent of sphingolipid signaling.


columnar/cuboidal epithelial cell development

The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.


formation of primary germ layer

The formation of the ectoderm, mesoderm and endoderm during gastrulation.


regulation of ERBB signaling pathway

Any process that modulates the frequency, rate or extent of ERBB signaling pathway.


isoprenoid catabolic process

The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


Tetracosanoic acid

A C24 straight-chain saturated fatty acid.


LCN1_HUMAN Lipocalin-1 (sprot)

A lipocalin-1 that is encoded in the genome of human.


LCN12_HUMAN Epididymal-specific lipocalin-12 (sprot)

An epididymal-specific lipocalin-12 that is encoded in the genome of human.


LCN15_HUMAN Lipocalin-15 (sprot)

A lipocalin-15 that is encoded in the genome of human.


LCN9_HUMAN Epididymal-specific lipocalin-9 (sprot)

An epididymal-specific lipocalin-9 that is encoded in the genome of human.


Arachidic Acid

A C20 striaght-chain saturated fatty acid which forms a minor constituent of peanut (L. arachis) and corn oils. Used as an organic thin film in the production of liquid crystals for a wide variety of technical applications.


plasma membrane bounded cell projection morphogenesis

The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized.


podocyte foot

A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms.


cyclin K-CDK12 complex

A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric

Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region.


Dimethylarsinate

The arsenic oxoanion that is the conjugate base of dimethylarsinic acid.


Dihydrogen arsenite

An arsenite ion resulting from the removal of a proton from one of the hydroxy groups of arsenous acid.


Methyl(dioxido)arsane

An arsenic oxoanion obtained deprotonation of both arsenite OH groups of methylarsonous acid.


Methyldopa

A derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring.


Carbidopa hydrate

The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.


A methylcatechol having a single methyl substituent at the 4-position. It has been isolated from Picea abies.


Benserazide

A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.


Aminopyrine

A  pyrazolone  that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.


Adinazolam

A triazolo[4,3-a][1,4]benzodiazepine having a dimethylaminomethyl group at the 1-position, a phenyl group at the 6-position and a chloro substituent at the 8-position.


3,4-Dihydroxy-5-methoxybenzoic acid

A member of the class of benzoic acids that is gallic acid in which the phenolic hydroxy group at position 3 is converted into the corresponding methyl ether.


A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol.


A chlorocatechol that is catechol substituted by a chloro group at position 4.


3,4-Dihydroxymandelic acid

A catechol that is the 3,4-dihydroxy derivative of mandelic acid; a metabolite of L-dopa.


Tetrachlorocatechol

A chlorocatechol that is catechol in which all of the hydrogens attached to the benzene ring are replaced by chlorines.


A dihydroxyacetophenone that is acetophenone carrying hydroxy groups at positions 3' and 4'.


A member of the class of catechols that is catechol in which a hydrogen that is ortho to one of the hydroxy groups has been replaced by a methoxy group. It displays agonistic activity against G protein-coupled receptor 35 (GPR35).


histone H3K9me2 methyltransferase activity

Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.


follicular dendritic cell differentiation

The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell.


peroxisome targeting sequence binding

Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome.


protein targeting to peroxisome

The process of directing proteins towards the peroxisome, usually using signals contained within the protein.


regulation of cell-substrate adhesion

Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


clathrin coat assembly

The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.


histone acetyltransferase KAT2B isoform 1 (mouse)

A histone acetyltransferase KAT2B isoform 1 that is encoded in the genome of mouse.


histone acetyltransferase KAT2A isoform 1 (mouse)

A histone acetyltransferase KAT2A isoform 1 that is encoded in the genome of mouse.


transcriptional adapter 3 isoform 1 (mouse)

A transcriptional adapter 3 isoform 1 that is encoded in the genome of mouse.


MAP3K12-binding inhibitory protein 1 isoform 1 (mouse)

A MAP3K12-binding inhibitory protein 1 isoform 1 that is encoded in the genome of mouse.


ZZ-type zinc finger-containing protein 3 isoform 1 (mouse)

A ZZ-type zinc finger-containing protein 3 isoform 1 that is encoded in the genome of mouse.


SAGA-associated factor 29 isoform 1 (mouse)

A SAGA-associated factor 29 isoform 1 that is encoded in the genome of mouse.


transcriptional adapter 2-alpha isoform 1 (mouse)

A transcriptional adapter 2-alpha isoform 1 that is encoded in the genome of mouse.


WD repeat-containing protein 5 isoform 1 (mouse)

A WD repeat-containing protein 5 isoform 1 that is encoded in the genome of mouse.


YEATS domain-containing protein 2 isoform 1 (mouse)

A YEATS domain-containing protein 2 isoform 1 that is encoded in the genome of mouse.


pyrimidine dimer repair

The repair of UV-induced T-T, C-T and C-C dimers.


trabecular meshwork development

The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.


L-lysine transmembrane transporter activity

Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid.


cationic amino acid transporter 2 isoform 1 (mouse)

A cationic amino acid transporter 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18581-1.


calcitonin gene-related peptide receptor activity

Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.


viral genome replication

Any process involved directly in viral genome replication, including viral nucleotide metabolism.


mitigation of host defenses by symbiont

A process by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


KR231_HUMAN Keratin-associated protein 23-1 (sprot)

A keratin-associated protein 23-1 that is encoded in the genome of human.


KRA97_HUMAN Keratin-associated protein 9-7 (sprot)

A keratin-associated protein 9-7 that is encoded in the genome of human.


KR161_HUMAN Keratin-associated protein 16-1 (sprot)

A keratin-associated protein 16-1 that is encoded in the genome of human.


KRA96_HUMAN Keratin-associated protein 9-6 (sprot)

A keratin-associated protein 9-6 that is encoded in the genome of human.


KR291_HUMAN Keratin-associated protein 29-1 (sprot)

A keratin-associated protein 29-1 that is encoded in the genome of human.


KRA91_HUMAN Keratin-associated protein 9-1 (sprot)

A keratin-associated protein 9-1 that is encoded in the genome of human.


KRT86_HUMAN Keratin, type II cuticular Hb6 (sprot)

A keratin, type II cuticular Hb6 that is encoded in the genome of human.


KRA58_HUMAN Keratin-associated protein 5-8 (sprot)

A keratin-associated protein 5-8 that is encoded in the genome of human.


KT33A_HUMAN Keratin, type I cuticular Ha3-I (sprot)

A keratin, type I cuticular Ha3-I that is encoded in the genome of human.


KRT34_HUMAN Keratin, type I cuticular Ha4 (sprot)

A keratin, type I cuticular Ha4 that is encoded in the genome of human.


KRT36_HUMAN Keratin, type I cuticular Ha6 (sprot)

A keratin, type I cuticular Ha6 that is encoded in the genome of human.


KRT37_HUMAN Keratin, type I cuticular Ha7 (sprot)

A keratin, type I cuticular Ha7 that is encoded in the genome of human.


KRT38_HUMAN Keratin, type I cuticular Ha8 (sprot)

A keratin, type I cuticular Ha8 that is encoded in the genome of human.


K2C75_HUMAN Keratin, type II cytoskeletal 75 (sprot)

A keratin, type II cytoskeletal 75 that is encoded in the genome of human.


K1C14_HUMAN Keratin, type I cytoskeletal 14 (sprot)

A keratin, type I cytoskeletal 14 that is encoded in the genome of human.


K2C6A_HUMAN Keratin, type II cytoskeletal 6A (sprot)

A keratin, type II cytoskeletal 6A that is encoded in the genome of human.


K2C6B_HUMAN Keratin, type II cytoskeletal 6B (sprot)

A keratin, type II cytoskeletal 6B that is encoded in the genome of human.


K1C18_HUMAN Keratin, type I cytoskeletal 18 (sprot)

A keratin, type I cytoskeletal 18 that is encoded in the genome of human.


K2C8_HUMAN Keratin, type II cytoskeletal 8 (sprot)

A keratin, type II cytoskeletal 8 that is encoded in the genome of human.


K1C19_HUMAN Keratin, type I cytoskeletal 19 (sprot)

A keratin, type I cytoskeletal 19 that is encoded in the genome of human.


K2C7_HUMAN Keratin, type II cytoskeletal 7 (sprot)

A keratin, type II cytoskeletal 7 that is encoded in the genome of human.


K1C16_HUMAN Keratin, type I cytoskeletal 16 (sprot)

A keratin, type I cytoskeletal 16 that is encoded in the genome of human.


KRA14_HUMAN Keratin-associated protein 1-4 (sprot)

A keratin-associated protein 1-4 that is encoded in the genome of human.


KRA23_HUMAN Keratin-associated protein 2-3 (sprot)

A keratin-associated protein 2-3 that is encoded in the genome of human.


K2C3_HUMAN Keratin, type II cytoskeletal 3 (sprot)

A keratin, type II cytoskeletal 3 that is encoded in the genome of human.


K1C10_HUMAN Keratin, type I cytoskeletal 10 (sprot)

A keratin, type I cytoskeletal 10 that is encoded in the genome of human.


K1C13_HUMAN Keratin, type I cytoskeletal 13 (sprot)

A keratin, type I cytoskeletal 13 that is encoded in the genome of human.


K2C5_HUMAN Keratin, type II cytoskeletal 5 (sprot)

A keratin, type II cytoskeletal 5 that is encoded in the genome of human.


K1C15_HUMAN Keratin, type I cytoskeletal 15 (sprot)

A keratin, type I cytoskeletal 15 that is encoded in the genome of human.


K2C4_HUMAN Keratin, type II cytoskeletal 4 (sprot)

A keratin, type II cytoskeletal 4 that is encoded in the genome of human.


KRA59_HUMAN Keratin-associated protein 5-9 (sprot)

A keratin-associated protein 5-9 that is encoded in the genome of human.


K1C9_HUMAN Keratin, type I cytoskeletal 9 (sprot)

A keratin, type I cytoskeletal 9 that is encoded in the genome of human.


K1C20_HUMAN Keratin, type I cytoskeletal 20 (sprot)

A keratin, type I cytoskeletal 20 that is encoded in the genome of human.


K22E_HUMAN Keratin, type II cytoskeletal 2 epidermal (sprot)

A keratin, type II cytoskeletal 2 epidermal that is encoded in the genome of human.


K2C6C_HUMAN Keratin, type II cytoskeletal 6C (sprot)

A keratin, type II cytoskeletal 6C that is encoded in the genome of human.


KR121_HUMAN Keratin-associated protein 12-1 (sprot)

A keratin-associated protein 12-1 that is encoded in the genome of human.


KR122_HUMAN Keratin-associated protein 12-2 (sprot)

A keratin-associated protein 12-2 that is encoded in the genome of human.


KR10A_HUMAN Keratin-associated protein 10-10 (sprot)

A keratin-associated protein 10-10 that is encoded in the genome of human.


KR123_HUMAN Keratin-associated protein 12-3 (sprot)

A keratin-associated protein 12-3 that is encoded in the genome of human.


KR124_HUMAN Keratin-associated protein 12-4 (sprot)

A keratin-associated protein 12-4 that is encoded in the genome of human.


KR101_HUMAN Keratin-associated protein 10-1 (sprot)

A keratin-associated protein 10-1 that is encoded in the genome of human.


KR102_HUMAN Keratin-associated protein 10-2 (sprot)

A keratin-associated protein 10-2 that is encoded in the genome of human.


KR103_HUMAN Keratin-associated protein 10-3 (sprot)

A keratin-associated protein 10-3 that is encoded in the genome of human.


KR105_HUMAN Keratin-associated protein 10-5 (sprot)

A keratin-associated protein 10-5 that is encoded in the genome of human.


KR106_HUMAN Keratin-associated protein 10-6 (sprot)

A keratin-associated protein 10-6 that is encoded in the genome of human.


KR104_HUMAN Keratin-associated protein 10-4 (sprot)

A keratin-associated protein 10-4 that is encoded in the genome of human.


KR107_HUMAN Keratin-associated protein 10-7 (sprot)

A keratin-associated protein 10-7 that is encoded in the genome of human.


KR108_HUMAN Keratin-associated protein 10-8 (sprot)

A keratin-associated protein 10-8 that is encoded in the genome of human.


KR109_HUMAN Keratin-associated protein 10-9 (sprot)

A keratin-associated protein 10-9 that is encoded in the genome of human.


KR10B_HUMAN Keratin-associated protein 10-11 (sprot)

A keratin-associated protein 10-11 that is encoded in the genome of human.


KR10C_HUMAN Keratin-associated protein 10-12 (sprot)

A keratin-associated protein 10-12 that is encoded in the genome of human.


KRT83_HUMAN Keratin, type II cuticular Hb3 (sprot)

A keratin, type II cuticular Hb3 that is encoded in the genome of human.


KRT85_HUMAN Keratin, type II cuticular Hb5 (sprot)

A keratin, type II cuticular Hb5 that is encoded in the genome of human.


K22O_HUMAN Keratin, type II cytoskeletal 2 oral (sprot)

A keratin, type II cytoskeletal 2 oral that is encoded in the genome of human.


K1C17_HUMAN Keratin, type I cytoskeletal 17 (sprot)

A keratin, type I cytoskeletal 17 that is encoded in the genome of human.


KRA11_HUMAN Keratin-associated protein 1-1 (sprot)

A keratin-associated protein 1-1 that is encoded in the genome of human.


KT33B_HUMAN Keratin, type I cuticular Ha3-II (sprot)

A keratin, type I cuticular Ha3-II that is encoded in the genome of human.


K1H2_HUMAN Keratin, type I cuticular Ha2 (sprot)

A keratin, type I cuticular Ha2 that is encoded in the genome of human.


KRT81_HUMAN Keratin, type II cuticular Hb1 (sprot)

A keratin, type II cuticular Hb1 that is encoded in the genome of human.


K2C72_HUMAN Keratin, type II cytoskeletal 72 (sprot)

A keratin, type II cytoskeletal 72 that is encoded in the genome of human.


K1H1_HUMAN Keratin, type I cuticular Ha1 (sprot)

A keratin, type I cuticular Ha1 that is encoded in the genome of human.


K1C24_HUMAN Keratin, type I cytoskeletal 24 (sprot)

A keratin, type I cytoskeletal 24 that is encoded in the genome of human.


KR251_HUMAN Keratin-associated protein 25-1 (sprot)

A keratin-associated protein 25-1 that is encoded in the genome of human.


KR213_HUMAN Keratin-associated protein 21-3 (sprot)

A keratin-associated protein 21-3 that is encoded in the genome of human.


KR192_HUMAN Keratin-associated protein 19-2 (sprot)

A primate-type keratin-associated protein 19-2 that is encoded in the genome of human.


KR198_HUMAN Keratin-associated protein 19-8 (sprot)

A keratin-associated protein 19-8 that is encoded in the genome of human.


KR211_HUMAN Keratin-associated protein 21-1 (sprot)

A keratin-associated protein 21-1 that is encoded in the genome of human.


KR212_HUMAN Keratin-associated protein 21-2 (sprot)

A keratin-associated protein 21-2 that is encoded in the genome of human.


KR202_HUMAN Keratin-associated protein 20-2 (sprot)

A keratin-associated protein 20-2 that is encoded in the genome of human.


KR201_HUMAN Keratin-associated protein 20-1 (sprot)

A keratin-associated protein 20-1 that is encoded in the genome of human.


KRA61_HUMAN Keratin-associated protein 6-1 (sprot)

A keratin-associated protein 6-1 that is encoded in the genome of human.


KRA62_HUMAN Keratin-associated protein 6-2 (sprot)

A keratin-associated protein 6-2 that is encoded in the genome of human.


KRA63_HUMAN Keratin-associated protein 6-3 (sprot)

A keratin-associated protein 6-3 that is encoded in the genome of human.


KR196_HUMAN Keratin-associated protein 19-6 (sprot)

A keratin-associated protein 19-6 that is encoded in the genome of human.


KR195_HUMAN Keratin-associated protein 19-5 (sprot)

A keratin-associated protein 19-5 that is encoded in the genome of human.


KR194_HUMAN Keratin-associated protein 19-4 (sprot)

A keratin-associated protein 19-4 that is encoded in the genome of human.


KR151_HUMAN Keratin-associated protein 15-1 (sprot)

A keratin-associated protein 15-1 that is encoded in the genome of human.


KR134_HUMAN Keratin-associated protein 13-4 (sprot)

A keratin-associated protein 13-4 that is encoded in the genome of human.


KR271_HUMAN Keratin-associated protein 27-1 (sprot)

A keratin-associated protein 27-1 that is encoded in the genome of human.


KR241_HUMAN Keratin-associated protein 24-1 (sprot)

A keratin-associated protein 24-1 that is encoded in the genome of human.


KR221_HUMAN Keratin-associated protein 22-1 (sprot)

A keratin-associated protein 22-1 that is encoded in the genome of human.


KR133_HUMAN Keratin-associated protein 13-3 (sprot)

A keratin-associated protein 13-3 that is encoded in the genome of human.


K2C71_HUMAN Keratin, type II cytoskeletal 71 (sprot)

A keratin, type II cytoskeletal 71 that is encoded in the genome of human.


KR197_HUMAN Keratin-associated protein 19-7 (sprot)

A keratin-associated protein 19-7 that is encoded in the genome of human.


KR132_HUMAN Keratin-associated protein 13-2 (sprot)

A keratin-associated protein 13-2 that is encoded in the genome of human.


K2C79_HUMAN Keratin, type II cytoskeletal 79 (sprot)

A keratin, type II cytoskeletal 79 that is encoded in the genome of human.


K1C40_HUMAN Keratin, type I cytoskeletal 40 (sprot)

A keratin, type I cytoskeletal 40 that is encoded in the genome of human.


K1C39_HUMAN Keratin, type I cytoskeletal 39 (sprot)

A keratin, type I cytoskeletal 39 that is encoded in the genome of human.


K2C80_HUMAN Keratin, type II cytoskeletal 80 (sprot)

A keratin, type II cytoskeletal 80 that is encoded in the genome of human.


KR511_HUMAN Keratin-associated protein 5-11 (sprot)

A keratin-associated protein 5-11 that is encoded in the genome of human.


KR510_HUMAN Keratin-associated protein 5-10 (sprot)

A keratin-associated protein 5-10 that is encoded in the genome of human.


KRA57_HUMAN Keratin-associated protein 5-7 (sprot)

A keratin-associated protein 5-7 that is encoded in the genome of human.


KRA56_HUMAN Keratin-associated protein 5-6 (sprot)

A keratin-associated protein 5-6 that is encoded in the genome of human.


KRA54_HUMAN Keratin-associated protein 5-4 (sprot)

A keratin-associated protein 5-4 that is encoded in the genome of human.


KRA53_HUMAN Keratin-associated protein 5-3 (sprot)

A keratin-associated protein 5-3 that is encoded in the genome of human.


KRA51_HUMAN Keratin-associated protein 5-1 (sprot)

A keratin-associated protein 5-1 that is encoded in the genome of human.


KR261_HUMAN Keratin-associated protein 26-1 (sprot)

A keratin-associated protein 26-1 that is encoded in the genome of human.


KRA55_HUMAN Keratin-associated protein 5-5 (sprot)

A keratin-associated protein 5-5 that is encoded in the genome of human.


KRA52_HUMAN Keratin-associated protein 5-2 (sprot)

A keratin-associated protein 5-2 that is encoded in the genome of human.


K2C74_HUMAN Keratin, type II cytoskeletal 74 (sprot)

A keratin, type II cytoskeletal 74 that is encoded in the genome of human.


K1C28_HUMAN Keratin, type I cytoskeletal 28 (sprot)

A keratin, type I cytoskeletal 28 that is encoded in the genome of human.


K1C27_HUMAN Keratin, type I cytoskeletal 27 (sprot)

A keratin, type I cytoskeletal 27 that is encoded in the genome of human.


K1C26_HUMAN Keratin, type I cytoskeletal 26 (sprot)

A keratin, type I cytoskeletal 26 that is encoded in the genome of human.


K1C25_HUMAN Keratin, type I cytoskeletal 25 (sprot)

A keratin, type I cytoskeletal 25 that is encoded in the genome of human.


KR193_HUMAN Keratin-associated protein 19-3 (sprot)

A keratin-associated protein 19-3 that is encoded in the genome of human.


K2C1B_HUMAN Keratin, type II cytoskeletal 1b (sprot)

A keratin, type II cytoskeletal 1b that is encoded in the genome of human.


K2C73_HUMAN Keratin, type II cytoskeletal 73 (sprot)

A keratin, type II cytoskeletal 73 that is encoded in the genome of human.


KR191_HUMAN Keratin-associated protein 19-1 (sprot)

A keratin-associated protein 19-1 that is encoded in the genome of human.


KR131_HUMAN Keratin-associated protein 13-1 (sprot)

A keratin-associated protein 13-1 that is encoded in the genome of human.


KR111_HUMAN Keratin-associated protein 11-1 (sprot)

A keratin-associated protein 11-1 that is encoded in the genome of human.


KRA81_HUMAN Keratin-associated protein 8-1 (sprot)

A keratin-associated protein 8-1 that is encoded in the genome of human.


KRA13_HUMAN Keratin-associated protein 1-3 (sprot)

A keratin-associated protein 1-3 that is encoded in the genome of human.


K2C78_HUMAN Keratin, type II cytoskeletal 78 (sprot)

A keratin, type II cytoskeletal 78 that is encoded in the genome of human.


KRT35_HUMAN Keratin, type I cuticular Ha5 (sprot)

A keratin, type I cuticular Ha5 that is encoded in the genome of human.


K1C12_HUMAN Keratin, type I cytoskeletal 12 (sprot)

A keratin, type I cytoskeletal 12 that is encoded in the genome of human.


KR171_HUMAN Keratin-associated protein 17-1 (sprot)

A keratin-associated protein 17-1 that is encoded in the genome of human.


KRA99_HUMAN Keratin-associated protein 9-9 (sprot)

A keratin-associated protein 9-9 that is encoded in the genome of human.


KRA98_HUMAN Keratin-associated protein 9-8 (sprot)

A keratin-associated protein 9-8 that is encoded in the genome of human.


KRA94_HUMAN Keratin-associated protein 9-4 (sprot)

A keratin-associated protein 9-4 that is encoded in the genome of human.


KRA93_HUMAN Keratin-associated protein 9-3 (sprot)

A keratin-associated protein 9-3 that is encoded in the genome of human.


KRA92_HUMAN Keratin-associated protein 9-2 (sprot)

A keratin-associated protein 9-2 that is encoded in the genome of human.


KRA46_HUMAN Keratin-associated protein 4-6 (sprot)

A keratin-associated protein 4-6 that is encoded in the genome of human.


KR411_HUMAN Keratin-associated protein 4-11 (sprot)

A keratin-associated protein 4-11 that is encoded in the genome of human.


KRA41_HUMAN Keratin-associated protein 4-1 (sprot)

A keratin-associated protein 4-1 that is encoded in the genome of human.


KRA49_HUMAN Keratin-associated protein 4-9 (sprot)

A keratin-associated protein 4-9 that is encoded in the genome of human.


KRA48_HUMAN Keratin-associated protein 4-8 (sprot)

A keratin-associated protein 4-8 that is encoded in the genome of human.


KRA47_HUMAN Keratin-associated protein 4-7 (sprot)

A keratin-associated protein 4-7 that is encoded in the genome of human.


KRA45_HUMAN Keratin-associated protein 4-5 (sprot)

A keratin-associated protein 4-5 that is encoded in the genome of human.


KRA44_HUMAN Keratin-associated protein 4-4 (sprot)

A keratin-associated protein 4-4 that is encoded in the genome of human.


KRA43_HUMAN Keratin-associated protein 4-3 (sprot)

A keratin-associated protein 4-3 that is encoded in the genome of human.


KRA42_HUMAN Keratin-associated protein 4-2 (sprot)

A keratin-associated protein 4-2 that is encoded in the genome of human.


KRA33_HUMAN Keratin-associated protein 3-3 (sprot)

A keratin-associated protein 3-3 that is encoded in the genome of human.


KRA32_HUMAN Keratin-associated protein 3-2 (sprot)

A keratin-associated protein 3-2 that is encoded in the genome of human.


KRA31_HUMAN Keratin-associated protein 3-1 (sprot)

A keratin-associated protein 3-1 that is encoded in the genome of human.


KRA24_HUMAN Keratin-associated protein 2-4 (sprot)

A keratin-associated protein 2-4 that is encoded in the genome of human.


KRA15_HUMAN Keratin-associated protein 1-5 (sprot)

A keratin-associated protein 1-5 that is encoded in the genome of human.


KRA22_HUMAN Keratin-associated protein 2-2 (sprot)

A keratin-associated protein 2-2 that is encoded in the genome of human.


KRA21_HUMAN Keratin-associated protein 2-1 (sprot)

A keratin-associated protein 2-1 that is encoded in the genome of human.


K1C23_HUMAN Keratin, type I cytoskeletal 23 (sprot)

A keratin, type I cytoskeletal 23 that is encoded in the genome of human.


KRT84_HUMAN Keratin, type II cuticular Hb4 (sprot)

A keratin, type II cuticular Hb4 that is encoded in the genome of human.


KRT82_HUMAN Keratin, type II cuticular Hb2 (sprot)

A keratin, type II cuticular Hb2 that is encoded in the genome of human.


regulation of hormone metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone.


opioid peptide activity

Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.


regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback

The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control.


efferent axon development in a lateral line nerve

The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve.


orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis

The process in which a lung bud bifurcates perpendicular to the plane of the previous bud.


planar dichotomous subdivision of terminal units involved in lung branching morphogenesis

The process in which a lung bud bifurcates parallel to the plane of the previous bud.


muscular septum morphogenesis

The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.


kidney morphogenesis

Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


establishment of planar polarity involved in neural tube closure

Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube.


planar cell polarity pathway involved in heart morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart.


gamma-aminobutyric acid:proton antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out).


positive regulation of histone H4-K16 acetylation

Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation.


lobar bronchus epithelium development

The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus.


VMAT1_HUMAN Chromaffin granule amine transporter (sprot)

A chromaffin granule amine transporter that is encoded in the genome of human.


JUN kinase binding

Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.


RNA polymerase binding

Binding to an RNA polymerase molecule or complex.


inositol trisphosphate phosphatase activity

Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate.


MD1L1_MOUSE Mitotic spindle assembly checkpoint protein MAD1 (sprot)

A mitotic spindle assembly checkpoint protein MAD1 that is encoded in the genome of mouse.


AURKC_MOUSE Aurora kinase C (sprot)

An aurora kinase C that is encoded in the genome of mouse.


positive regulation of protein autoubiquitination

Any process that activates or increases the frequency, rate or extent of protein autoubiquitination.


sodium channel regulator activity

Binds to and modulates the activity of a sodium channel.


regulation of sodium ion transmembrane transporter activity

Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.


mu-type opioid receptor binding

Binding to a mu-type opioid receptor.


B7ZJH6_MOUSE Sigma non-opioid intracellular receptor 1 (trembl)

A sigma non-opioid intracellular receptor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B7ZJH6.


sigma non-opioid intracellular receptor 1 isoform m2 (mouse)

A sigma non-opioid intracellular receptor 1 isoform 3 that is encoded in the genome of mouse.


B7ZJH7_MOUSE Sigma non-opioid intracellular receptor 1 (trembl)

A sigma non-opioid intracellular receptor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B7ZJH7.


B7ZJH9_MOUSE Sigma non-opioid intracellular receptor 1 (trembl)

A sigma non-opioid intracellular receptor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B7ZJH9.


B7ZJH8_MOUSE Sigma non-opioid intracellular receptor 1 (trembl)

A sigma non-opioid intracellular receptor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B7ZJH8.


negative regulation of hepatocyte proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation.


hyperplasia

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement.


steroid dehydrogenase activity

Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative.


Tyrosol

A phenol substituted at position 4 by a 2-hydroxyethyl group.


A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.


A member of the class of  quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an  epidermal growth factor receptor antagonist.


Sorbinil

An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.


Trolox

A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capacity of complex mixtures.


Amorolfine

A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.


Hydroxytyrosol

A member of the class of catechols that is benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. Isolated from Olea europaea, it exhibits antioxidant and antineoplastic activities.


A member of the class of  pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor, it exhibits anticancer property.


Oleuropein

A secoiridoid glycoside that is the methyl ester of 3,4-dihydro-2H-pyran-5-carboxylic acid which is substituted at positions 2, 3, and 4 by hydroxy, ethylidene, and carboxymethyl groups, respectively and in which the anomeric hydroxy group at position 2 has been converted into its beta-D-glucoside and the carboxylic acid moiety of the carboxymethyl substituent has been converted to the corresponding 3,4-dihydroxyphenethyl ester (the 2S,3E,4S stereoisomer). The most important phenolic compound present in olive cultivars.


Etodolac

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.


Butenafine

Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.


Benzoic acid, 4-(4-((2R,5R)-5-((bis(phenylmethyl)amino)carbonyl)-2-heptyl-4-oxo-3-thiazolidinyl)butyl)-, rel-


Scalaradial

A scalarane sesterterpenoid with formula C27H40O4. It is a natural product found in the marine sponges Spongia officinalis and Cacospongia mollior, and exhibits anti-inflammatory activity.


Manoalide

A sesterterpenoid isolated from the marine sponge Luffariella variabilis and which has been shown to exhibit inhibitory activity towards phospholipase A2.


telomere cap complex

A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.


negative regulation of apoptotic DNA fragmentation

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation.


negative regulation of retinal cone cell fate commitment

Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell.


retinal rod cell fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye.


negative regulation of amacrine cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation.


lamin binding

Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.


lamin filament

Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.


H60B_MOUSE Histocompatibility antigen 60b (sprot)

A protein that is a translation product of the H60b gene in mouse.


MHC class I protein binding

Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


MHC class Ib receptor activity

Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.


HA12_MOUSE H-2 class I histocompatibility antigen, D-D alpha chain (sprot)

An H-2 class I histocompatibility antigen D1 alpha chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01900.


HA1D_MOUSE H-2 class I histocompatibility antigen, K-D alpha chain (sprot)

An H-2 class I histocompatibility antigen K1 alpha chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01902.


MFSD6_MOUSE Major facilitator superfamily domain-containing protein 6 (sprot)

A major facilitator superfamily domain-containing protein 6 that is encoded in the genome of mouse.


developmental cell growth

The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.


acylglycerol metabolic process

The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.


dolichol biosynthetic process

The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units.


protein mannosylation

The addition of a mannose residue to a protein acceptor molecule.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose.


regulation of Rho guanyl-nucleotide exchange factor activity

Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.


hyaloid vascular plexus regression

The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression.


regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.


regulation of tube size

Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes.


nephron tubule morphogenesis

The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney.


uterus morphogenesis

The process in which anatomical structures of the uterus are generated and organized.


mesonephric tubule development

The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros.


kidney rudiment formation

The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


metanephric tubule formation

The developmental process pertaining to the initial formation of a metanephric tubule.


male genital tubercle

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A differentiated genital tubercle that is part of a male reproductive system.


membrane depolarization during SA node cell action potential

The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


voltage-gated calcium channel activity involved SA node cell action potential

Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


positive regulation of mitochondrial membrane permeability involved in apoptotic process

Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process.


positive regulation of retinoic acid receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


retinoic acid binding

Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid.


positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway.


regulation of growth hormone activity

Any process that modulates the frequency, rate or extent of growth hormone activity.


regulation of spongiotrophoblast cell proliferation

Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation.


ammonium transmembrane transport

The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+.


transition between slow and fast fiber

The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.


amylase activity

Catalysis of the hydrolysis of amylose or an amylose derivative.


Tie signaling pathway

The series of molecular signals initiated by an angiopoietin binding to the Tie receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


plasma membrane fusion

The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.


white matter of spinal cord

The regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites.


The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.


negative regulation of zinc ion transmembrane transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other.


TNR18_HUMAN Tumor necrosis factor receptor superfamily member 18 (sprot)

A tumor necrosis factor receptor superfamily member 18 that is encoded in the genome of human.


CTLA4_HUMAN Cytotoxic T-lymphocyte protein 4 (sprot)

A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of human.


D3 dopamine receptor binding

Binding to a D3 dopamine receptor.


negative regulation of adenylate cyclase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.


DRD3_MOUSE D(3) dopamine receptor (sprot)

A D(3) dopamine receptor that is encoded in the genome of mouse.


cullin-RING ubiquitin ligase complex

Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.


metal ion binding

Binding to a metal ion.


detoxification of copper ion

Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion.


cellular response to chromate

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus.


regulation of systemic arterial blood pressure by hormone

The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.


renal tubular secretion

The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.


positive regulation of estrogen secretion

Any process that activates or increases the frequency, rate or extent of estrogen secretion.


sperm annulus

The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity.


clathrin-sculpted acetylcholine transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle.


APBA1_HUMAN Amyloid-beta A4 precursor protein-binding family A member 1 (sprot)

An amyloid-beta A4 precursor protein-binding family A member 1 that is encoded in the genome of human.


CSKP_HUMAN Peripheral plasma membrane protein CASK (sprot)

A peripheral plasma membrane protein CASK that is encoded in the genome of human.


LIN7B_HUMAN Protein lin-7 homolog B (sprot)

A protein lin-7 homolog B that is encoded in the genome of human.


LIN7A_HUMAN Protein lin-7 homolog A (sprot)

A protein lin-7 homolog A that is encoded in the genome of human.


LIN7C_HUMAN Protein lin-7 homolog C (sprot)

A protein lin-7 homolog C that is encoded in the genome of human.


An oxoicosatetraenoic acid having a 12-oxo group; and (5Z)-, (8Z), (10E)- and (14Z)-double bonds.


cyclin K-CDK13 complex

A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


MYH9_MOUSE Myosin-9 (sprot)

A myosin-9 that is encoded in the genome of mouse.


isoleucine catabolic process

The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.


leucine metabolic process

The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid.


valine metabolic process

The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.


isoleucine metabolic process

The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.


atrial septum primum morphogenesis

The process in which anatomical structure of an atrial septum primum is generated and organized.


atrial septum secundum morphogenesis

The process in which anatomical structure of an atrial septum secundum is generated and organized.


insulin-like growth factor binding protein complex

A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development.


regulation of acyl-CoA biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA.


regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.


localization within membrane

Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.


odorant binding

Binding to an odorant, any substance capable of stimulating the sense of smell.


medullary thymic epithelial cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output.


regulation of ventricular cardiac muscle cell membrane depolarization

Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte.


positive regulation of striated muscle tissue development

Any process that activates or increases the frequency, rate or extent of striated muscle development.


milk ejection reflex

A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness.


IgE immunoglobulin complex, circulating

A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


neural plate axis specification

The pattern specification process in which the axes of the nervous system are established.


negative regulation of cell proliferation involved in contact inhibition

Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density.


development of primary female sexual characteristics

The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.


IgM binding

Binding to an immunoglobulin of the IgM isotype.


immunoglobulin transcytosis in epithelial cells

The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.


paranasal sinus

The paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity.


macromolecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


protein depalmitoylation

The removal of palymitoyl groups from a lipoprotein.


negative regulation of phosphatase activity

Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.


immunoglobulin receptor binding

Binding to one or more specific sites on an immunoglobulin receptor molecule.


T cell differentiation involved in immune response

The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.


CCR4-NOT complex

The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8.


PDXL2_HUMAN Podocalyxin-like protein 2 (sprot)

A podocalyxin-like protein 2 that is encoded in the genome of human.


somatic cell DNA recombination

Recombination occurring within or between DNA molecules in somatic cells.


planar cell polarity pathway involved in cardiac right atrium morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium.


KLRB1_MOUSE Killer cell lectin-like receptor subfamily B member 1 (sprot)

A killer cell lectin-like receptor subfamily B member 1G that is encoded in the genome of mouse.


olfactory lobe development

The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell.


dendritic growth cone

The migrating motile tip of a growing nerve cell dendrite.


sarcoplasmic reticulum lumen

The volume enclosed by the membranes of the sarcoplasmic reticulum.


regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion

Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


leukotriene B4 receptor activity

Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.


CXCR4 chemokine receptor binding

Binding to a CXCR4 chemokine receptor.


peroxiredoxin activity

Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.


filopodium membrane

The portion of the plasma membrane surrounding a filopodium.


AQP7_HUMAN Aquaporin-7 (sprot)

An aquaporin-7 that is encoded in the genome of human.


AQP9_HUMAN Aquaporin-9 (sprot)

An aquaporin-9 that is encoded in the genome of human.


Roundabout binding

Binding to Roundabout (ROBO) receptor, a transmembrane receptor.


dorsal/ventral axon guidance

The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.


spleen trabecula formation

The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod.


response to iron ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.


gonad morphogenesis

The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.


anoctamin-7 isoform 1 (mouse)

An anoctamin-7 isoform 1 that is encoded in the genome of mouse.


regulation of sodium-dependent phosphate transport

Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport.


CD99 antigen-like protein 2 isoform m2 (mouse)

A CD99 antigen-like protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BIF0-2.


CD99 antigen-like protein 2 isoform m1 (mouse)

A CD99 antigen-like protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BIF0-1.


nucleoside triphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.


nucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.


glycosphingolipid

A glycosphingolipid is a glycolipid that is a carbohydrate-containing derivative of a sphingoid or ceramide. It is understood that the carbohydrate residue is attached by a glycosidic linkage to O-1 of the sphingoid.


A glycotetraosylceramide having N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose as the tetrasaccharide component.


SUMF2_HUMAN Inactive C-alpha-formylglycine-generating enzyme 2 (sprot)

An inactive C-alpha-formylglycine-generating enzyme 2 that is encoded in the genome of human.


An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide; major species at pH 7.3.


A sialotriaosylceramide consisting of the pentasaccharide beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc attached to the primary hydroxy function of ceramide.


An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of ganglioside GT2; major species at pH 7.3.


An N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide in which the ceramide N-acyl group is specified as stearoyl.


An organosulfate oxoanion obtained by deprotonation of the sulfate group of N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide; major species at pH 7.3.


snRNA binding

Binding to a small nuclear RNA (snRNA).


cyclin/CDK positive transcription elongation factor complex

A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.


adenyl deoxyribonucleotide binding

Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.


cellular response to type I interferon

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


generation of precursor metabolites and energy

The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.


immune complex formation

The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus.


DNA modification

The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.


T cell antigen processing and presentation

The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.


CD86 biosynthetic process

The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival.


DNA synthesis involved in UV-damage excision repair

Any DNA synthesis that is involved in UV-damage excision repair.


single stranded viral RNA replication via double stranded DNA intermediate

A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II.


deoxyribonuclease II activity

Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products.


oxalic acid secretion

The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue.


Glyoxylate

The conjugate base of glyoxylic acid.


An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.


COP9 signalosome

A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.


bronchus morphogenesis

The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs.


negative regulation of meiotic cell cycle phase transition

Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition.


prostaglandin F receptor activity

Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity.


positive regulation of myotome development

Any process that activates or increases the frequency, rate or extent of myotome development.


oncostatin-M receptor activity

Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


An N-acetyl-D-galactosamine having alpha-configuration at the anomeric centre.


carbohydrate derivative binding

Binding to a carbohydrate derivative.


negative regulation of actin filament severing

Any process that stops, prevents or reduces the frequency, rate or extent of actin filament severing.


positive regulation of actin filament severing

Any process that activates or increases the frequency, rate or extent of actin filament severing.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol.


tRNA 2'-phosphotransferase activity

Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate.


isoprenoid binding

Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


structural constituent of tooth enamel

The action of a molecule that contributes to the structural integrity of tooth enamel.


positive regulation of oxidoreductase activity

Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.


glial cell-derived neurotrophic factor receptor binding

A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors.


microglial cell activation involved in immune response

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


ectoderm and mesoderm interaction

A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm.


cloacal septation

The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development.


heterotypic cell-cell adhesion

The attachment of a cell to a cell of a different type via adhesion molecules.


pyrimidine-specific mismatch base pair DNA N-glycosylase activity

Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.


copper ion transmembrane transport

The directed movement of copper cation across a membrane.


Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).


protein arginylation

The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway.


negative regulation of transcription of nucleolar large rRNA by RNA polymerase I

Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I.


filamin binding

Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.


inner cell mass cell fate commitment

The cell fate commitment of precursor cells that will become inner cell mass cells.


positive regulation of epidermal growth factor-activated receptor activity

Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity.


positive regulation of complement-dependent cytotoxicity

Any process that activates or increases the frequency, rate or extent of complement-dependent cytotoxicity.


PeBoW complex

A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.


pancreatic juice secretion

The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.


RNA-DNA hybrid ribonuclease activity

Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.


negative regulation of asymmetric cell division

Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.


fibular nerve

Any nerve that innervates the fibularis. Includes the common fibular nerve, and its branches.


septin collar

A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell.


DNA ligation involved in DNA recombination

The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination.


DNA ligation involved in DNA repair

The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair.


intestinal lipid catabolic process

The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas.


detection of virus

The series of events in which a stimulus from a virus is received and converted into a molecular signal.


DNA-binding transcription repressor activity

A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.


tripeptidyl-peptidase activity

Catalysis of the release of an N-terminal tripeptide from a polypeptide.


regulation of monoatomic anion transport

Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cerebrospinal fluid secretion

The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces.


Cul5-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


regulation of arginine metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate.


lipid kinase activity

Catalysis of the phosphorylation of a simple or complex lipid.


regulation of mesenchymal cell proliferation

Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


AKAP5_MOUSE A-kinase anchor protein 5 (sprot)

An A-kinase anchor protein 5 that is encoded in the genome of mouse.


establishment of protein localization to membrane

The directed movement of a protein to a specific location in a membrane.


The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.


phosphocreatine metabolic process

The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle.


phosphocreatine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase.


A D-fructofuranose 6-phosphate with a beta-configuration at the anomeric position.


Glutamic Acid

An optically active form of glutamic acid having L-configuration.


D-glucosamine 6-phosphate

A glucosamine phosphate that is D-glucosamine substituted by a phosphate group at position 6.


negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


pheromone activity

The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant.


CSF3R_MOUSE Granulocyte colony-stimulating factor receptor (sprot)

A granulocyte colony-stimulating factor receptor that is encoded in the genome of mouse.


granulocyte colony-stimulating factor receptor activity

Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.


Zwitterionic form of anserine.


N-beta-alanyl-L-histidine

Zwitterionic form of carnosine.


Dizwitterionic form of L-cystathionine arising from transfer of two protons from the carboxy to the amino groups; major species at pH 7.3.


A 2-oxo monocarboxylic acid anion that is the conjugate base of 2-oxobutanoic acid, obtained by deprotonation of the carboxy group.


macrophage colony-stimulating factor receptor binding

Binding to a macrophage colony-stimulating factor receptor.


dTTP biosynthetic process

The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.


angiotensin type II receptor activity

An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms.


diplotene

The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.


TRAIL binding

Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines.


noelin isoform 1 (mouse)

A noelin isoform 1 that is encoded in the genome of mouse.


noelin isoform 2 (mouse)

A noelin isoform 2 that is encoded in the genome of mouse. This isoform has Gly at position 153, and the C-terminal region 154-485 is missing.


regulation of dendritic spine development

Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


glycine decarboxylation via glycine cleavage system

The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.


PACR_MOUSE Pituitary adenylate cyclase-activating polypeptide type I receptor (sprot)

A pituitary adenylate cyclase-activating polypeptide type I receptor that is encoded in the genome of mouse.


negative regulation of vascular endothelial growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.


cytoplasmic sequestering of transcription factor

The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.


BRCA2-BRAF35 complex

A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis.


NEDD8 activating enzyme activity

Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.


endomitotic cell cycle

A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.


cellular response to triacyl bacterial lipopeptide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus.


detection of triacyl bacterial lipopeptide

The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups.


diacyl lipopeptide binding

Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups.


detection of diacyl bacterial lipopeptide

The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups.


positive regulation of lymphocyte apoptotic process

Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.


oocyte differentiation

The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.


response to organonitrogen compound

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.


fever generation

The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.


regulation of CD40 signaling pathway

Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway.


hedgehog family protein binding

Binding to a member of the hedgehog protein family, signaling proteins involved in development.


L-phenylalanine catabolic process

The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.


negative regulation of osteoclast development

Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.


positive regulation of protein-containing complex assembly

Any process that activates or increases the frequency, rate or extent of protein complex assembly.


CPNE6_HUMAN Copine-6 (sprot)

A copine-6 that is encoded in the genome of human.


CPNE7_HUMAN Copine-7 (sprot)

A copine-7 that is encoded in the genome of human.


actin filament severing

The process in which an actin filament is broken down into smaller filaments.


bilirubin conjugation

The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin.


glycitein 4'-O-glucuronide

A glycosyloxyisoflavone that is the glucuronide-conjugated form of the phytoestrogen glycitein.


chloride:monoatomic cation symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in).


chloride transmembrane transport

The process in which chloride is transported across a membrane.


ribosomal protein S6 kinase activity

Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.


non-kinase phorbol ester receptor activity

Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity.


synaptic vesicle, readily releasable pool

A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton.