An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 2-docosenoic acid. The product of dehydrogenation of behenoyl-CoA


Behenyl-coenzyme A

A very long-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of docosanoic (behenic) acid.


A mono-unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any 2-methylpentadecenoic acid.


ACPM_HUMAN Acyl carrier protein, mitochondrial (sprot)

An acyl carrier protein, mitochondrial that is encoded in the genome of human.


ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 (sprot)

A phospholipid-transporting ATPase ABCA1 that is encoded in the genome of human.


ANGL4_HUMAN Angiopoietin-related protein 4 (sprot)

An angiopoietin-related protein 4 that is encoded in the genome of human.


G0S2_HUMAN G0/G1 switch protein 2 (sprot)

A G0/G1 switch protein 2 that is encoded in the genome of human.


ACADM_HUMAN Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (sprot)

A medium-chain specific acyl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.


PX11A_HUMAN Peroxisomal membrane protein 11A (sprot)

A peroxisomal membrane protein 11A that is encoded in the genome of human.


GRHL1_HUMAN Grainyhead-like protein 1 homolog (sprot)

A grainyhead-like protein 1 that is encoded in the genome of human.


ST2A1_HUMAN Sulfotransferase 2A1 (sprot)

A sulfotransferase 2A1 that is encoded in the genome of human.


MAOX_HUMAN NADP-dependent malic enzyme (sprot)

An NADP-dependent malic enzyme that is encoded in the genome of human.


ANKR1_HUMAN Ankyrin repeat domain-containing protein 1 (sprot)

An ankyrin repeat domain-containing protein 1 that is encoded in the genome of human.


FHL2_HUMAN Four and a half LIM domains protein 2 (sprot)

A four and a half LIM domains protein 2 that is encoded in the genome of human.


TNR21_HUMAN Tumor necrosis factor receptor superfamily member 21 (sprot)

A tumor necrosis factor receptor superfamily member 21 that is encoded in the genome of human.


APOA2_HUMAN Apolipoprotein A-II (sprot)

An apolipoprotein A-II that is encoded in the genome of human.


peroxisomal acyl-coenzyme A oxidase 1 isoform h1 (human)

A peroxisomal acyl-coenzyme A oxidase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15067-1.


positive regulation of MHC class I biosynthetic process

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.


antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.


regulation of MHC class I biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.


tumor protein p53-inducible nuclear protein 1 isoform 2 (mouse)

A tumor protein p53-inducible nuclear protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QXE4-2.


regulation of signal transduction by receptor internalization

Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway.


regulation of nerve growth factor receptor activity

Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor.


mannosidase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative.


hydrolase activity, hydrolyzing N-glycosyl compounds

Catalysis of the hydrolysis of any N-glycosyl bond.


blastocele

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Fluid-filled central region of a blastocyst.


collagen type IV trimer

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.


chaperonin-containing T-complex

A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.


T-complex protein 1 subunit eta isoform 1 phosphorylated 1 (mouse)

A T-complex protein 1 subunit eta isoform 1 phosphorylated 1 in mouse. UniProtKB:P80313-1, Thr-57, MOD:00047|Ser-59, MOD:00046.


T-complex protein 1 subunit epsilon isoform 1 phosphorylated 1 (mouse)

A T-complex protein 1 subunit epsilon isoform 1 phosphorylated 1 in mouse. UniProtKB:P80316-1, Ser-270, MOD:00046.


inferior colliculus development

The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally.


olfactory nerve development

The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.


regulation of synapse structure or activity

Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).


sialic acid binding

Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.


anterior neuropore closure

The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete.


negative regulation of wound healing

Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.


regulation of synaptic vesicle recycling

Any process that modulates the frequency, rate or extent of synaptic vesicle recycling.


negative regulation of molecular function

Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.


cervix development

The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure.


Q99232_MOUSE Carcinoembryonic antigen family member protein (trembl)

A carcinoembryonic antigen-related cell adhesion molecule 1 sequence variant CEACAM1b (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99232. This form contains the two copies of the Ig domain and is the version with shorter cytoplasmic tail.


cell killing

Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.


acetyl group

A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.


p-Phenetidine

An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin.


positive regulation of cellular component biogenesis

Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.


magnesium ion transport

The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


positive regulation of T cell costimulation

Any process that activates or increases the frequency, rate or extent of T cell costimulation.


negative regulation of proteolysis involved in protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process.


regulation of nucleocytoplasmic transport

Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.


negative regulation of ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


hydroperoxide

A monosubstitution product of hydrogen peroxide, HOOH.


transmembrane-ephrin receptor activity

Combining with a transmembrane ephrin to initiate a change in cell activity.


axon guidance receptor activity

Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.


hippocampal commissure

The triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side.


regulation of systemic arterial blood pressure

The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.


FK506 binding

Binding to a 23-membered macrolide lactone FK506.


peptidyl-proline modification

The modification of peptidyl-proline.


negative regulation of synapse assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.


POZ domain binding

Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.


4-Nitrophenyl phosphate

An aryl phosphate resulting from the mono-esterification of phosphoric acid with 4-nitrophenol.


CASP8 and FADD-like apoptosis regulator isoform h2 (human)

A CASP8 and FADD-like apoptosis regulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15519-2.


presenilin-2 isoform PS2short (mouse)

A presenilin-2 isoform PS2short that is encoded in the genome of mouse. UniProtKB:Q61144-1, 298-448.


death-associated protein kinase 1 isoform 1 (mouse)

A death-associated protein kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80YE7-1.


phospholipase A2 activator activity

Binds to and increases the activity of the enzyme phospholipase A2.


transcription corepressor binding

Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.


cellular response to X-ray

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).


protein localization to pericentric heterochromatin

A process in which a protein is transported to, or maintained in the pericentric heterochromatin.


C5AR2_HUMAN C5a anaphylatoxin chemotactic receptor 2 (sprot)

A C5a anaphylatoxin chemotactic receptor 2 that is encoded in the genome of human.


CFAI_HUMAN Complement factor I (sprot)

A complement factor I that is encoded in the genome of human.


CR2_HUMAN Complement receptor type 2 (sprot)

A complement receptor type 2 that is encoded in the genome of human.


FHR3_HUMAN Complement factor H-related protein 3 (sprot)

A complement factor H-related protein 3 that is encoded in the genome of human.


G-quadruplex RNA binding

Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.


cellular response to high light intensity

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.


retinal rod cell apoptotic process

Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.


Ral protein signal transduction

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.


negative regulation of tolerance induction

Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction.


Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+.


trochlear nerve development

The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.


oculomotor nerve development

The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.


oculomotor nerve

Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles.


histone methyltransferase complex

A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.


general adaptation syndrome

General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses.


response to insecticide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.


sperm plasma membrane

A plasma membrane that is part of a sperm cell.


glycolipid biosynthetic process

The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).


negative regulation of cell fate determination

Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination.


negative regulation of stomach neuroendocrine cell differentiation

Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.


regulation of stem cell differentiation

Any process that modulates the frequency, rate or extent of stem cell differentiation.


biological process involved in interaction with symbiont

An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.


response to hydroperoxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.


mesonephric duct morphogenesis

The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros.


body morphogenesis

The process in which the anatomical structures of the soma are generated and organized.


EIF3B_MOUSE Eukaryotic translation initiation factor 3 subunit B (sprot)

A eukaryotic translation initiation factor 3 subunit B that is encoded in the genome of mouse.


IF4A2_MOUSE Eukaryotic initiation factor 4A-II (sprot)

A eukaryotic initiation factor 4A-II that is encoded in the genome of mouse.


translation repressor activity, non-nucleic acid binding

Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid.


PMEPA_HUMAN Protein TMEPAI (sprot)

A protein TMEPAI that is encoded in the genome of human.


BAMBI_HUMAN BMP and activin membrane-bound inhibitor homolog (sprot)

A BMP and activin membrane-bound inhibitor that is encoded in the genome of human.


CATB_MOUSE Cathepsin B (sprot)

A cathepsin B that is encoded in the genome of mouse.


DPP2_MOUSE Dipeptidyl peptidase 2 (sprot)

A dipeptidyl peptidase 2 that is encoded in the genome of mouse.


HEXA_MOUSE Beta-hexosaminidase subunit alpha (sprot)

A beta-hexosaminidase subunit alpha that is encoded in the genome of mouse.


glutamate-cysteine ligase catalytic subunit binding

Binding to the catalytic subunit of glutamate-cysteine ligase.


positive regulation of glutamate-cysteine ligase activity

Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.


TBP_HUMAN TATA-box-binding protein (sprot)

A TATA-box-binding protein that is encoded in the genome of human.


UBF1_HUMAN Nucleolar transcription factor 1 (sprot)

A nucleolar transcription factor 1 that is encoded in the genome of human.


RRN3_HUMAN RNA polymerase I-specific transcription initiation factor RRN3 (sprot)

An RNA polymerase I-specific transcription initiation factor RRN3 that is encoded in the genome of human.


RPAC1_HUMAN DNA-directed RNA polymerases I and III subunit RPAC1 (sprot)

A DNA-directed RNA polymerases I and III subunit RPAC1 that is encoded in the genome of human.


RPA12_HUMAN DNA-directed RNA polymerase I subunit RPA12 (sprot)

A DNA-directed RNA polymerase I subunit RPA12 that is encoded in the genome of human.


RPAB5_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC5 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC5 that is encoded in the genome of human.


RPAB3_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC3 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC3 that is encoded in the genome of human.


RPC22_HUMAN Protein POLR1D, isoform 2 (sprot)


RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 (sprot)

A DNA-directed RNA polymerase I subunit RPA1 that is encoded in the genome of human.


RPAB4_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC4 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC4 that is encoded in the genome of human.


RPAB2_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC2 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC2 that is encoded in the genome of human.


RPAB1_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC1 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC1 that is encoded in the genome of human.


TAF1D_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit D (sprot)

A TATA box-binding protein-associated factor RNA polymerase I subunit D that is encoded in the genome of human.


TAF1B_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit B (sprot)

A TATA box-binding protein-associated factor RNA polymerase I subunit B that is encoded in the genome of human.


TAF1A_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit A (sprot)

A TATA box-binding protein-associated factor RNA polymerase I subunit A that is encoded in the genome of human.


RPA34_HUMAN DNA-directed RNA polymerase I subunit RPA34 (sprot)

A DNA-directed RNA polymerase I subunit RPA34 that is encoded in the genome of human.


TAF1C_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit C (sprot)

A TATA box-binding protein-associated factor RNA polymerase I subunit C that is encoded in the genome of human.


RPA49_HUMAN DNA-directed RNA polymerase I subunit RPA49 (sprot)

A DNA-directed RNA polymerase I subunit RPA49 that is encoded in the genome of human.


RPA2_HUMAN DNA-directed RNA polymerase I subunit RPA2 (sprot)

A DNA-directed RNA polymerase I subunit RPA2 that is encoded in the genome of human.


RPA43_HUMAN DNA-directed RNA polymerase I subunit RPA43 (sprot)

A DNA-directed RNA polymerase I subunit RPA43 that is encoded in the genome of human.


aryl hydrocarbon receptor binding

Binding to an aryl hydrocarbon receptor.


Phenylacetaldehyde

An aldehyde that consists of acetaldehyde bearing a methyl substituent; the parent member of the phenylacetaldehyde class of compounds.


A propanal having an amino substituent at the 3-position


An alpha-amino-acid anion that is the conjugate base of N-benzoylglycine; major species at pH 7.3.


An N-acyl-L-alpha-amino acid anion that is the conjugate base of N(2)-phenylacetyl-L-glutamine; major species at pH 7.3.


A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.


A phosphorodiamide that is the active metabolite of the nitrogen mustard cyclophosphamide. It has potent antineoplastic and immunosuppressive properties.


Doxorubicinol

A member of the class of tetracenequinones that is the major metabolite of the anthracycline doxorubicin, a chemotherapeutic agent effective against a broad range of malignant neoplasms. It is thought to exhibit cardiotoxic properties.


Benzaldehyde

An arenecarbaldehyde that consists of benzene bearing a single formyl substituent; the simplest aromatic aldehyde and parent of the class of benzaldehydes.


Benzoylecgonine

A  benzoate ester metabolite of cocaine formed by hydrolysis of the methyl ester group, catalysed by carboxylesterases.


An isoquinoline that is 3,4-dihydroisoquinoline bearing amidino and hydroxy substituent at positions 2 and 4 respectively.


Cyclopropylamine

A primary aliphatic amine that consists of cyclopropane bearing a single amino substituent.


Tamoxifen N-oxide

A tertiary amine oxide resulting from the formal oxidation of the amino group of tamoxifen.


Trimethylamine oxide

A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.


4-Aminosalicylic acid

An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.


Acetylisoniazid

A carbohydrazide resulting from the formal condensation of the carboxy group of isonicotinic acid with hydrazine and subsequent acetylation of the monosubstituted nitrogen atom.


AHRR_HUMAN Aryl hydrocarbon receptor repressor (sprot)

An aryl hydrocarbon receptor repressor that is encoded in the genome of human.


ARNT2_HUMAN Aryl hydrocarbon receptor nuclear translocator 2 (sprot)

An aryl hydrocarbon receptor nuclear translocator 2 that is encoded in the genome of human.


Sulfanilamide

A sulfonamide in which the sulfamoyl functional group is attached to aniline at the 4-position.


An N-acetoxyarylamine having 1,1'-biphenyl-4-amine as the arylamine component.


An amidobenzoate that is the conjugate base of 4-acetamidobenzoic acid, arising from deprotonation of the carboxy group; major species at pH 7.3.


An amidobenzoate that is the conjugate base of 4-acetamidosalicylic acid, arising from deprotonation of the carboxy group; major species at pH 7.3.


Sulfacetamide

A sulfonamide that is sulfanilamide acylated on the sulfonamide nitrogen.


large conductance calcium-activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


negative regulation of cell volume

Any process that decreases cell volume.


negative regulation of p38MAPK cascade

Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.


negative regulation of establishment of protein localization to mitochondrion

Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion.


negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide.


R4JNM3_MOUSE Anti-Mullerian hormone type 2 receptor delta 9/10 (Fragment) (trembl)

An anti-Muellerian hormone type-2 receptor isoform Delta9/10 that is encoded in the genome of mouse. This sequence lacks the region encoded by exons 9 and 10, which is part of the protein kinase domain.


negative regulation of anti-Mullerian hormone signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway.


R4JKA2_MOUSE Anti-Mullerian hormone type 2 receptor delta 2 (Fragment) (trembl)

An anti-Muellerian hormone type-2 receptor isoform Delta2 that is encoded in the genome of mouse. This sequence lacks the region encoded by exon 2 which is part of the extracellular domain and it is essential for ligand binding.


anti-Muellerian hormone type-2 receptor isoform 1 (mouse)

An anti-Muellerian hormone type-2 receptor isoform 1 that is encoded in the genome of mouse.


anti-Mullerian hormone receptor activity

Combining with anti-Mullerian hormone to initiate a change in cell activity.


anti-Mullerian hormone signaling pathway

The series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


brush border cell of the proximal tubule

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow.


antral ovarian follicle growth

Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.


follicle-stimulating hormone signaling pathway

A G protein-coupled receptor signaling pathway initiated by follicle-stimulating hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


activation of prostate induction by androgen receptor signaling pathway

The series of molecular signals initiated by androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland.


tyrosine-protein kinase SYK isoform 1 phosphorylated 6 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at positions 519 and 520, but it is still phosphorylated at Tyr 342 and 346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048|Tyr-519/Tyr-520, PR:000026291.


tyrosine-protein kinase SYK isoform 1 unphosphorylated 3 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 346. UniProtKB:P48025-1, Tyr-346, PR:000026291.


tyrosine-protein kinase SYK isoform 1 unphosphorylated 2 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 342. UniProtKB:P48025-1, Tyr-342, PR:000026291.


tyrosine-protein kinase SYK isoform 1 phosphorylated 2 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342. UniProtKB:P48025-1, Tyr-342, MOD:00048.


tyrosine-protein kinase SYK isoform 1 phosphorylated 5 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342, Tyr-346, Tyr-519 and Tyr-520. UniProtKB:P48025-1, Tyr-342/Tyr-346/Tyr-519/Tyr-520, MOD:00048.


tyrosine-protein kinase SYK isoform 1 phosphorylated 4 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342 and Tyr-346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048.


positive regulation of response to type II interferon

Any process that increases the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus.


interleukin-8 receptor activity

Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


microtubule anchoring at centrosome

Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome.


The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome.


regulation of microtubule-based process

Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.


negative regulation of T-helper 2 cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.


small ribosomal subunit

The smaller of the two subunits of a ribosome.


negative regulation of membrane protein ectodomain proteolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.


positive regulation of membrane protein ectodomain proteolysis

Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.


neuregulin-1 type I-beta1a transmembrane precursor (mouse)

A neuregulin-1 type I-beta1a (mouse) that has not been proteolytically processed.


neuregulin-1 type I-beta4a transmembrane precursor (mouse)

A neuregulin-1 type I-beta4a (mouse) that has not been proteolytically processed.


negative regulation of cell cycle G1/S phase transition

Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.


climbing fiber

The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber.


cerebellar molecular layer development

The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.


L-cysteine catabolic process to taurine

The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine.


hedgehog receptor activity

Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.


positive regulation of epidermal cell differentiation

Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.


response to chlorate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus.


planar cell polarity pathway involved in pericardium morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium.


prevention of polyspermy

The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg.


regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.


oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule.


mitochondrial electron transfer flavoprotein complex

A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system.


mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis

The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


chorion development

The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane.


negative regulation of endopeptidase activity

Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


positive regulation of leukocyte tethering or rolling

Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling.


leukocyte adhesion to vascular endothelial cell

The attachment of a leukocyte to vascular endothelial cell via adhesion molecules.


TNFL9_MOUSE Tumor necrosis factor ligand superfamily member 9 (sprot)

A tumor necrosis factor ligand superfamily member 9 that is encoded in the genome of mouse.


mononuclear cell migration

The movement of a mononuclear cell within or between different tissues and organs of the body.


negative regulation of calcium ion import

Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.


lateral septal complex

The lateral septal area; largest nuclear mass in this region, plays a pivotal role in various physiological processes, such as aggression, emotion, thermoregulation, water and food intake and sexual behaviour.


lateral geniculate nucleus development

The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina.


ribosomal small subunit binding

Binding to a small ribosomal subunit.


positive regulation of cellular biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.


Rho GDP-dissociation inhibitor binding

Binding to a Rho GDP-dissociation inhibitor protein.


response to intra-S DNA damage checkpoint signaling

A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling.


negative regulation of insulin secretion involved in cellular response to glucose stimulus

Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.


enzyme binding

Binding to an enzyme, a protein with catalytic activity.


spindle pole centrosome

A centrosome from which one pole of a mitotic or meiotic spindle is organized.


zygote asymmetric cell division

The division of the zygote into two daughter cells that will adopt developmentally distinct potentials.


vitamin K biosynthetic process

The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals.


eukaryotic translation initiation factor 3 complex, eIF3m

An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.


regulation of collateral sprouting of intact axon in response to injury

Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon.


TFIIB-class transcription factor binding

Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


positive regulation of CREB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.


growth plate cartilage chondrocyte morphogenesis

The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized.


GPI anchor release

The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane.


positive regulation of cellular response to insulin stimulus

Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.


preribosome

Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis.


mediator of RNA polymerase II transcription subunit 1 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 1 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 24 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 24 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 21 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 21 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 14 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 14 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 28 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 28 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 18 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 18 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 31 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 31 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 4 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 4 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 8 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 8 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 27 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 27 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 6 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 6 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 23 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 23 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 26 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 26 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 12 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 12 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 20 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 20 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 15 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 15 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 16 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 16 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 17 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 17 isoform 1 that is encoded in the genome of mouse.


mediator of RNA polymerase II transcription subunit 13 isoform 1 (mouse)

A mediator of RNA polymerase II transcription subunit 13 isoform 1 that is encoded in the genome of mouse.


actin-myosin filament sliding

The sliding movement of actin thin filaments and myosin thick filaments past each other.


parasympathetic nervous system development

The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.


trochlear nerve

A cranial nerve that runs to the eye muscles.


noradrenergic neuron development

The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


I-SMAD binding

Binding to an inhibitory SMAD signaling protein.


negative regulation of protein metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.


SMAD6_MOUSE Mothers against decapentaplegic homolog 6 (sprot)

A smad6 that is encoded in the genome of mouse.


misfolded RNA binding

Binding to an RNA molecule that has assumed an incorrect conformation.


regulation of stem cell division

Any process that modulates the frequency, rate or extent of stem cell division.


regulation of binding of sperm to zona pellucida

Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida.


acetylcholine receptor inhibitor activity

Binds to and stops, prevents or reduces the activity of an acetylcholine receptor.


ACHA_MOUSE Acetylcholine receptor subunit alpha (sprot)

An acetylcholine receptor subunit alpha that is encoded in the genome of mouse.


ACHA3_MOUSE Neuronal acetylcholine receptor subunit alpha-3 (sprot)

A neuronal acetylcholine receptor subunit alpha-3 that is encoded in the genome of mouse.


perivitelline space

The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane).


egg coat

A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.


negative regulation of binding of sperm to zona pellucida

Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida.


polarity specification of proximal/distal axis

Any process resulting in the establishment of polarity along the proximal/distal axis.


left lung morphogenesis

The process in which anatomical structures of the left lung are generated and organized.


maternal process involved in parturition

A reproductive process occurring in the mother that results in birth.


floor plate morphogenesis

The process in which the anatomical structure of the floor plate is generated and organized.


epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification

Any process that mediates the transfer of information from an epiblast cell to an extraembryonic ectoderm cell that contributes to the specification of the anterior/posterior axis.


adiponectin binding

Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism.


L-Methionine (S)-S-oxide

The (S)-oxido diastereomer of L-methionine S-oxide.


membranous septum morphogenesis

The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.


lateral sprouting from an epithelium

The process in which a branch forms along the side of an epithelium.


coronal suture morphogenesis

The process in which the coronal suture is generated and organized.


response to methylglyoxal

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.


regulation of myoblast differentiation

Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


regulation of cell growth by extracellular stimulus

Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.


tangential migration from the subventricular zone to the olfactory bulb

The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.


positive thymic T cell selection

The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.


positive regulation of phospholipase activity

Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.


actin-mediated cell contraction

The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.


dephosphorylation

The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.


negative regulation of phosphoprotein phosphatase activity

Any process that stops or reduces the activity of a phosphoprotein phosphatase.


myocardin isoform 3 (mouse)

A myocardin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8VIM5-3.


myocardin isoform 4 (mouse)

A myocardin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8VIM5-4.


IQEC2_HUMAN IQ motif and SEC7 domain-containing protein 2 (sprot)

An IQ motif and SEC7 domain-containing protein 2 that is encoded in the genome of human.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + HCO3-(out) = chloride(out) + HCO3-(in).


kidney outer medulla collecting duct intercalated cell

Intercalated cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may contribute in the maintenance of acid/base homeostasis.


cellular response to corticosterone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.


negative regulation of actin filament depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.


The trianion resulting from the removal of the three protons from the diphosphate group of all-trans-pentaprenyl diphosphate; major species at pH 7.3.


All-trans-hexaprenyl diphosphate(3-)

The trianion resulting from the removal of the three protons from the diphosphate group of all-trans-hexaprenyl diphosphate; major species at pH 7.3.


transcription elongation by RNA polymerase I

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.


negative regulation of telomere maintenance

Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.


Dolichyl D-mannosyl phosphate

A polyprenyl glycosyl phosphate having dolichyl as the polyprenyl component and D-mannose as the glycosyl component.


negative regulation of mast cell cytokine production

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production.


positive regulation of mast cell cytokine production

Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production.


left-handed Z-DNA binding

Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags.


negative regulation of post-transcriptional gene silencing by regulatory ncRNA

Any process that stops, prevents or reduces the frequency, rate or extent of post-transcriptional gene silencing by RNA.


RISC complex assembly

The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing completent complex that mediates gene silencing by small RNA.


base conversion or substitution editing

Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s).


somatic diversification of immune receptors via somatic mutation

The process in which immune receptor genes are diversified through somatic mutation.


positive regulation of T cell cytokine production

Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.


phosphatidylinositol trisphosphate phosphatase activity

Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate.


PTB domain binding

Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain.


claudin-18 isoform mA2.1 (mouse)

A claudin-18 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56857-3.


syntaxin-3 binding

Binding to a syntaxin-3 SNAP receptor.


interleukin-11 binding

Binding to interleukin-11.


IL11_MOUSE Interleukin-11 (sprot)

An interleukin-11 that is encoded in the genome of mouse.


interleukin-1 receptor binding

Binding to an interleukin-1 receptor.


IL1R1_MOUSE Interleukin-1 receptor type 1 (sprot)

An interleukin-1 receptor type 1 that is encoded in the genome of mouse.


negative regulation of toll-like receptor 2 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.


IL1R2_MOUSE Interleukin-1 receptor type 2 (sprot)

An interleukin-1 receptor type 2 that is encoded in the genome of mouse.


calpain-3 isoform Short (mouse)

A calpain-3 isoform 2 that is encoded in the genome of mouse.


EGLN_MOUSE Endoglin (sprot)

An endoglin that is encoded in the genome of mouse.


N-formyl peptide receptor activity

Combining with an N-formyl peptide to initiate a change in cell activity.


phosphorus-oxygen lyase activity

Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


regulation of Ral protein signal transduction

Any process that modulates the frequency, rate or extent of Ral protein signal transduction.


positive regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that activates or increases the frequency, rate or extent of CDK activity.


organophosphate metabolic process

The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound.


myosin II complex

A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures.


cell adhesion molecule binding

Binding to a cell adhesion molecule.


leukotriene production involved in inflammatory response

The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.


Hsp90 protein binding

Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.


ribosomal protein import into nucleus

The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus.


IMA8_MOUSE Importin subunit alpha-8 (sprot)

An importin subunit alpha-8 that is encoded in the genome of mouse.


RL11_MOUSE Large ribosomal subunit protein uL5 (sprot)

A 60S ribosomal protein L11 that is encoded in the genome of mouse.


calcium-dependent protein binding

Binding to a protein or protein complex in the presence of calcium.


WIPI3_HUMAN WD repeat domain phosphoinositide-interacting protein 3 (sprot)

A WD repeat domain phosphoinositide-interacting protein 3 that is encoded in the genome of human.


WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein 4 (sprot)

A WD repeat domain phosphoinositide-interacting protein 4 that is encoded in the genome of human.


observational learning

Learning that occurs through observing the behavior of others.


gamma-aminobutyric acid secretion, neurotransmission

The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter.


PLXA4_MOUSE Plexin-A4 (sprot)

A plexin-A4 that is encoded in the genome of mouse.


negative regulation of transcription by RNA polymerase III

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III.


thoracic cavity

The part of the coelemic cavity lumen that is enclosed by the walls of the thorax.


L-proline import across plasma membrane

The directed movement of L-proline from outside of a cell, across the plasma membrane and into the cytosol.


negative regulation of alpha-beta T cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation.


sodium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a sodium channel.


acetyl-CoA biosynthetic process

The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.


positive regulation of calcium-dependent cell-cell adhesion

Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion.


cellular response to histamine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.


interleukin-11 receptor binding

Binding to an interleukin-11 receptor.


I11RA_MOUSE Interleukin-11 receptor subunit alpha-1 (sprot)

An interleukin-11 receptor subunit alpha-1 that is encoded in the genome of mouse.


metalloendopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.


regulation of toll-like receptor signaling pathway

Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.


Octanoate

A straight-chain saturated fatty acid anion that is the conjugate base of octanoic acid (caprylic acid); believed to block adipogenesis.


natural killer cell activation involved in immune response

The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


positive regulation of NK T cell activation

Any process that activates or increases the frequency, rate or extent of natural killer T cell activation.


endogenous lipid antigen binding

Binding to an endogenous cellular lipid antigen.


T cell receptor binding

Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells.


cerebellar granule cell precursor tangential migration

The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.


low voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.


response to nickel cation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus.


TBA4A_MOUSE Tubulin alpha-4A chain (sprot)

A tubulin alpha-4A chain that is encoded in the genome of mouse.


GDNF family receptor alpha-2 isoform 4 (mouse)

A GDNF family receptor alpha-2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O08842-2.


regulation of smooth muscle cell migration

Any process that modulates the frequency, rate or extent of smooth muscle cell migration.


negative regulation of smooth muscle cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.


inner dynein arm

Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.


negative regulation of neutrophil degranulation

Any process that stops, prevents, or reduces the rate of neutrophil degranulation.


regulation of microvillus assembly

A process that modulates the formation of a microvillus.


secretory cell

A cell that specializes in controlled release of one or more substances.


extracellularly glutamate-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.


HFE_HUMAN Hereditary hemochromatosis protein (sprot)

A hereditary hemochromatosis protein that is encoded in the genome of human.


TFR2_HUMAN Transferrin receptor protein 2 (sprot)

A transferrin receptor protein 2 that is encoded in the genome of human.


cardiogenic plate

The first recognizable structure derived from the heart field.


apoptotic process in bone marrow cell

The apoptotic process in cells in the bone marrow.


CD8-positive, gamma-delta intraepithelial T cell differentiation

The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.


negative regulation of leukocyte chemotaxis

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.


CD8-positive, alpha-beta intraepithelial T cell differentiation

The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.


peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine.


protein-arginine omega-N monomethyltransferase activity

Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine.


peptidyl-arginine omega-N-methylation

The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein.


nuclear stress granule

A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.


polarity specification of anterior/posterior axis

Any process resulting in the establishment of polarity along the anterior/posterior axis.


MTMR9_HUMAN Myotubularin-related protein 9 (sprot)

A myotubularin-related protein 9 that is encoded in the genome of human.


MTMRC_HUMAN Myotubularin-related protein 12 (sprot)

A myotubularin-related protein 12 that is encoded in the genome of human.


MTMRA_HUMAN Myotubularin-related protein 10 (sprot)

A myotubularin-related protein 10 that is encoded in the genome of human.


MTMR8_HUMAN Myotubularin-related protein 8 (sprot)

A myotubularin-related protein 8 that is encoded in the genome of human.


PKHA8_HUMAN Pleckstrin homology domain-containing family A member 8 (sprot)

A pleckstrin homology domain-containing family A member 8 that is encoded in the genome of human.


PKHA4_HUMAN Pleckstrin homology domain-containing family A member 4 (sprot)

A pleckstrin homology domain-containing family A member 4 that is encoded in the genome of human.


PKHA5_HUMAN Pleckstrin homology domain-containing family A member 5 (sprot)

A pleckstrin homology domain-containing family A member 5 that is encoded in the genome of human.


PKHA3_HUMAN Pleckstrin homology domain-containing family A member 3 (sprot)

A pleckstrin homology domain-containing family A member 3 that is encoded in the genome of human.


PKHA6_HUMAN Pleckstrin homology domain-containing family A member 6 (sprot)

A pleckstrin homology domain-containing family A member 6 that is encoded in the genome of human.


positive regulation of kinase activity

Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


reproductive system development

The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.


NDUF7_HUMAN Protein arginine methyltransferase NDUFAF7, mitochondrial (sprot)

A protein arginine methyltransferase NDUFAF7, mitochondrial that is encoded in the genome of human.


NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5 (sprot)

An NADH-ubiquinone oxidoreductase chain 5 that is encoded in the genome of human.


NU4M_HUMAN NADH-ubiquinone oxidoreductase chain 4 (sprot)

An NADH-ubiquinone oxidoreductase chain 4 that is encoded in the genome of human.


NDUAC_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 that is encoded in the genome of human.


NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 (sprot)

An NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 that is encoded in the genome of human.


NDUS5_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 that is encoded in the genome of human.


NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial that is encoded in the genome of human.


NDUB6_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (sprot)

An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 that is encoded in the genome of human.


NUBPL_HUMAN Iron-sulfur protein NUBPL (sprot)

A nucleotide-binding protein-like that is encoded in the genome of human.


NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 that is encoded in the genome of human.


NDUV3_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial that is encoded in the genome of human.


NDUS6_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial that is encoded in the genome of human.


NDUF2_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 that is encoded in the genome of human.


NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 (sprot)

An NADH-ubiquinone oxidoreductase chain 1 that is encoded in the genome of human.


NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 that is encoded in the genome of human.


NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6 (sprot)

An NADH-ubiquinone oxidoreductase chain 6 that is encoded in the genome of human.


NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial (sprot)

An arginine-hydroxylase NDUFAF5, mitochondrial that is encoded in the genome of human.


NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial that is encoded in the genome of human.


NDUV2_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial that is encoded in the genome of human.


TIDC1_HUMAN Complex I assembly factor TIMMDC1, mitochondrial (sprot)

A complex I assembly factor TIMMDC1, mitochondrial that is encoded in the genome of human.


NDUS8_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial that is encoded in the genome of human.


NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial that is encoded in the genome of human.


NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial that is encoded in the genome of human.


NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (sprot)

An NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial that is encoded in the genome of human.


metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of development, heterochronic

Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.


positive regulation of NAD+ ADP-ribosyltransferase activity

Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.


handplate apical ectodermal ridge

An apical ectodermal ridge that is part of a handplate.


nucleologenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells.


G protein-coupled neurotensin receptor activity

Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.


intermediate filament cytoskeleton

Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.


regulation of germinal center formation

Any process that modulates the frequency, rate, or extent of germinal center formation.


MutSalpha complex binding

Binding to a MutSalpha mismatch repair complex.


MutLalpha complex binding

Binding to a MutLalpha mismatch repair complex.


protein carboxylation

The addition of a carboxy group to a protein amino acid.


vascular endothelial growth factor receptor 3 binding

Binding to a vascular endothelial growth factor receptor 3.


Merkel cell

A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber.


prickle cell

A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin.


positive regulation of syncytium formation by plasma membrane fusion

Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


syncytiotrophoblast cell

A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.


chorion-specific transcription factor GCMa acetylated 1 (mouse)

A chorion-specific transcription factor GCMa acetylated 1 in mouse. UniProtKB:P70348, Lys-367/Lys-406, MOD:00064.


chorionic trophoblast cell differentiation

The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.


regulation of chorionic trophoblast cell proliferation

Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation.


chorionic trophoblast cell proliferation

The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population.


positive T cell selection

The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.


positive regulation of axon regeneration

Any process that activates, maintains or increases the rate of axon regeneration.


pericardial cavity

A potential space between the visceral and parietal layers of the pericardium.


positive regulation of mesoderm development

Any process that activates or increases the frequency, rate or extent of mesoderm development.


receptor localization to synapse

Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


regulation of receptor localization to synapse

Any process that modulates the frequency, rate or extent of receptor localization to synapse.


GRIK1_MOUSE Glutamate receptor ionotropic, kainate 1 (sprot)

A glutamate receptor ionotropic, kainate 1 that is encoded in the genome of mouse.


Cul4A-RING E3 ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.


Sucrose

A glycosyl glycoside formed by glucose and fructose units joined by an acetal oxygen bridge from hemiacetal of glucose to the hemiketal of the fructose.


GRM4_HUMAN Metabotropic glutamate receptor 4 (sprot)

A metabotropic glutamate receptor 4 that is encoded in the genome of human.


D-Tryptophan

The D-enantiomer of tryptophan.


mitogen-activated protein kinase 14 isoform 1 (mouse)

A mitogen-activated protein kinase 14 isoform 1 that is encoded in the genome of mouse.


positive regulation of mitochondrial membrane potential

Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


positive regulation of fibroblast apoptotic process

Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.


mitochondrial outer membrane permeabilization

The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.


A multilamellar subcellular structure formed in the cytoplasm of developing neuron, composed of Tmem240 and Emd proteins.


positive regulation of cGMP-mediated signaling

Any process that increases the rate, frequency or extent of cGMP-mediated signaling.


negative regulation of interleukin-13 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production.


anterograde synaptic vesicle transport

The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.


selenocysteine biosynthetic process

The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.


positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.


nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).


thymidylate kinase activity

Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.


dTDP biosynthetic process

The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).


regulation of exocyst assembly

Any process that modulates the frequency, rate or extent of exocyst assembly.


calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.


response to type II interferon

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.


vasoactive intestinal polypeptide receptor activity

Combining with vasoactive intestinal polypeptide to initiate a change in cell activity.


negative regulation of cytokine production involved in immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.


glomerulus vasculature development

The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus.


regulation of macrophage migration inhibitory factor signaling pathway

Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway.


negative regulation of vascular permeability

Any process that reduces the extent to which blood vessels can be pervaded by fluid.


calcium-dependent phospholipid binding

Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.


protein-N-terminal asparagine amidohydrolase activity

Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein.


establishment of body hair planar orientation

Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface.


structural constituent of myelin sheath

The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve.


histamine-induced gastric acid secretion

The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP.


OTOF_DANRE Otoferlin (sprot)

An otoferlin that is encoded in the genome of zebrafish.


OTOF_MOUSE Otoferlin (sprot)

An otoferlin that is encoded in the genome of mouse.


TRML1_MOUSE Trem-like transcript 1 protein (sprot)

A trem-like transcript 1 protein that is encoded in the genome of mouse.


detection of wounding

The series of events by which an injury stimulus is received and converted into a molecular signal.


mesenchyme migration

The process in which the population of cells that make up a mesenchyme undergo directed movement.


right lung morphogenesis

The process in which anatomical structures of the right lung are generated and organized.


LIGO1_HUMAN Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (sprot)

A leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 that is encoded in the genome of human.


MAG_HUMAN Myelin-associated glycoprotein (sprot)

A myelin-associated glycoprotein that is encoded in the genome of human.


OMGP_HUMAN Oligodendrocyte-myelin glycoprotein (sprot)

An oligodendrocyte-myelin glycoprotein that is encoded in the genome of human.


RTN4_HUMAN Reticulon-4 (sprot)

A reticulon-4 that is encoded in the genome of human.


cerebellar layer

A cortical cell layer of the cerebellum. Examples: the granular (inner+outer) layer, molecular layer, Purkinje cell layer, and the ventricular layer of the embryo.


actin monomer binding

Binding to monomeric actin, also known as G-actin.


intracellular monoatomic anion homeostasis

A homeostatic process involved in the maintenance of a steady state level of monoatomic anions within a cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom.


ACBD6_HUMAN Acyl-CoA-binding domain-containing protein 6 (sprot)

An acyl-CoA-binding domain-containing protein 6 that is encoded in the genome of human.


ACBP_HUMAN Acyl-CoA-binding protein (sprot)

An acyl-CoA-binding protein that is encoded in the genome of human.


ACBD7_HUMAN Acyl-CoA-binding domain-containing protein 7 (sprot)

An acyl-CoA-binding domain-containing protein 7 that is encoded in the genome of human.


gamma-catenin binding

Binding to catenin complex gamma subunit.


O89096_MOUSE Fibroblast growth factor (trembl)

A fibroblast growth factor 14 isoform 3 that is encoded in the genome of mouse.


oxidoreductase activity, acting on peroxide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor.


negative regulation of release of cytochrome c from mitochondria

Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.


acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure

The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure.


response to hyperoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.


detection of oxygen

The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.


erythrophore differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance.


minus-end-directed microtubule motor activity

A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis.


muscle alpha-actinin binding

Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.


negative regulation of neutrophil apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.


protein localization to cell leading edge

A process in which a protein is transported to, or maintained in, a location within a cell leading edge.


8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.


Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.


negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.


serotonin binding

Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.


phospholipase C-activating serotonin receptor signaling pathway

A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


positive regulation of myeloid leukocyte differentiation

Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.


stabilization of membrane potential

The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


calcium-activated potassium channel subunit alpha-1 isoform 4 (mouse)

A calcium-activated potassium channel subunit alpha-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08460-4.


calcium-activated potassium channel subunit alpha-1 isoform 1 (mouse)

A calcium-activated potassium channel subunit alpha-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08460-1.


superior vena cava morphogenesis

The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart.


pulmonary vein morphogenesis

The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart.


Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


hemoglobin binding

Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


ankyrin binding

Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.


negative regulation of urine volume

Any process that decreases the amount of urine excreted from the body over a unit of time.


plasma membrane phospholipid scrambling

The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).


pH elevation

Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.


ANK1_MOUSE Ankyrin-1 (sprot)

An ankyrin-1 that is encoded in the genome of mouse.


ornithine decarboxylase inhibitor activity

Binds to and stops, prevents or reduces the activity of ornithine decarboxylase.


susceptibility to natural killer cell mediated cytotoxicity

The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.


natural killer cell lectin-like receptor binding

Binding to a lectin-like natural killer cell receptor.


positive regulation of endosome to plasma membrane protein transport

Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport.


copper ion homeostasis

Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell.


sorting endosome

A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles.


very-low-density lipoprotein particle receptor activity

Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.


low-density lipoprotein particle binding

Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.


spermine metabolic process

The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.


negative regulation of lipopolysaccharide-mediated signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.


regulation of hydrogen peroxide metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide.


Q3TJI3_MOUSE Ubiquitin thioesterase CYLD (trembl)

A ubiquitin carboxyl-terminal hydrolase CYLD (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3TJI3.


positive regulation of ion transmembrane transporter activity

Any process that activates or increases the activity of an ion transporter.


diacylglycerol binding

Binding to a diacylglycerol, a diester of glycerol and two fatty acids.


response to pheromone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.


inter-male aggressive behavior

Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.


mating behavior, sex discrimination

The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner.


negative regulation of male mating behavior

Any process that stops, prevents or reduces the frequency, rate or extent of male mating behavior.


territorial aggressive behavior

Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics.


male germ-line stem cell population maintenance

The process by which an organism or tissue maintains a population of male germ-line stem cells.


nuclear body organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.