1433E_HUMAN 14-3-3 protein epsilon (sprot)

A 14-3-3 protein epsilon that is encoded in the genome of human.


SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (sprot)

A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of human.


APBB1_HUMAN Amyloid beta precursor protein binding family B member 1 (sprot)

An amyloid beta precursor protein binding family B member 1 that is encoded in the genome of human.


TRI14_HUMAN Tripartite motif-containing protein 14 (sprot)

A tripartite motif-containing protein 14 that is encoded in the genome of human.


STK3_HUMAN Serine/threonine-protein kinase 3 (sprot)

A serine/threonine-protein kinase 3 that is encoded in the genome of human.


GNA12_HUMAN Guanine nucleotide-binding protein subunit alpha-12 (sprot)

A guanine nucleotide-binding protein subunit alpha-12 that is encoded in the genome of human.


GNA13_HUMAN Guanine nucleotide-binding protein subunit alpha-13 (sprot)

A guanine nucleotide-binding protein subunit alpha-13 that is encoded in the genome of human.


TRI55_HUMAN Tripartite motif-containing protein 55 (sprot)

A tripartite motif-containing protein 55 that is encoded in the genome of human.


TAXB1_HUMAN Tax1-binding protein 1 (sprot)

A Tax1-binding protein 1 that is encoded in the genome of human.


PRKRA_HUMAN Interferon-inducible double-stranded RNA-dependent protein kinase activator A (sprot)

An interferon-inducible double-stranded RNA-dependent protein kinase activator A that is encoded in the genome of human.


BLVRB_HUMAN Flavin reductase (NADPH) (sprot)

A flavin reductase that is encoded in the genome of human.


IRS1_HUMAN Insulin receptor substrate 1 (sprot)

An insulin receptor substrate 1 that is encoded in the genome of human.


ABI2_HUMAN Abl interactor 2 (sprot)

An Abl interactor 2 that is encoded in the genome of human.


TRDMT_HUMAN tRNA (cytosine(38)-C(5))-methyltransferase (sprot)

A tRNA (cytosine-5-)-methyltransferase that is encoded in the genome of human.


GTDC1_HUMAN Glycosyltransferase-like domain-containing protein 1 (sprot)

A glycosyltransferase-like domain-containing protein 1 that is encoded in the genome of human.


B3GNL_HUMAN UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 (sprot)

A UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 that is encoded in the genome of human.


FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP5 that is encoded in the genome of human.


PHLP1_HUMAN PH domain leucine-rich repeat-containing protein phosphatase 1 (sprot)

A PH domain leucine-rich repeat-containing protein phosphatase that is encoded in the genome of human.


UBP49_HUMAN Ubiquitin carboxyl-terminal hydrolase 49 (sprot)

A ubiquitin carboxyl-terminal hydrolase 49 that is encoded in the genome of human.


TSC1_HUMAN Hamartin (sprot)

A hamartin that is encoded in the genome of human.


SAV1_HUMAN Protein salvador homolog 1 (sprot)

A protein salvador homolog 1 that is encoded in the genome of human.


LATS2_HUMAN Serine/threonine-protein kinase LATS2 (sprot)

A serine/threonine-protein kinase LATS2 that is encoded in the genome of human.


1433B_HUMAN 14-3-3 protein beta/alpha (sprot)

A 14-3-3 protein beta/alpha that is encoded in the genome of human.


WWC2_HUMAN Protein WWC2 (sprot)

A protein WWC2 that is encoded in the genome of human.


MERL_HUMAN Merlin (sprot)

A merlin that is encoded in the genome of human.


LATS1_HUMAN Serine/threonine-protein kinase LATS1 (sprot)

A serine/threonine-protein kinase LATS1 that is encoded in the genome of human.


MOB1B_HUMAN MOB kinase activator 1B (sprot)

A MOB kinase activator 1B that is encoded in the genome of human.


STK4_HUMAN Serine/threonine-protein kinase 4 (sprot)

A serine/threonine-protein kinase 4 that is encoded in the genome of human.


MOB1A_HUMAN MOB kinase activator 1A (sprot)

A MOB kinase activator 1A that is encoded in the genome of human.


KIBRA_HUMAN Protein KIBRA (sprot)

A protein WWC1 that is encoded in the genome of human.


M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (sprot)

A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of human.


FAR/SIN/STRIPAK complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body.


WWC3_HUMAN Protein WWC3 (sprot)

A protein WWC3 that is encoded in the genome of human.


SLMAP_HUMAN Sarcolemmal membrane-associated protein (sprot)

A sarcolemmal membrane-associated protein that is encoded in the genome of human.


BCL10_HUMAN B-cell lymphoma/leukemia 10 (sprot)

A B-cell lymphoma/leukemia 10 that is encoded in the genome of human.


TRI62_HUMAN E3 ubiquitin-protein ligase TRIM62 (sprot)

An E3 ubiquitin-protein ligase TRIM62 that is encoded in the genome of human.


MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (sprot)

A mucosa-associated lymphoid tissue lymphoma translocation protein 1 that is encoded in the genome of human.


CARD9_HUMAN Caspase recruitment domain-containing protein 9 (sprot)

A caspase recruitment domain-containing protein 9 that is encoded in the genome of human.


GRB2_HUMAN Growth factor receptor-bound protein 2 (sprot)

A growth factor receptor-bound protein 2 that is encoded in the genome of human.


VAV_HUMAN Proto-oncogene vav (sprot)

A proto-oncogene vav that is encoded in the genome of human.


TYW3_HUMAN tRNA wybutosine-synthesizing protein 3 homolog (sprot)

A tRNA wybutosine-synthesizing protein 3 that is encoded in the genome of human.


TYW4_HUMAN tRNA wybutosine-synthesizing protein 4 (sprot)

A tRNA wybutosine-synthesizing protein 4 that is encoded in the genome of human.


TYW2_HUMAN tRNA wybutosine-synthesizing protein 2 homolog (sprot)

A tRNA wybutosine-synthesizing protein 2 that is encoded in the genome of human.


TRM9B_HUMAN Probable tRNA methyltransferase 9B (sprot)

A probable tRNA methyltransferase 9B that is encoded in the genome of human.


TRM13_HUMAN tRNA:m(4)X modification enzyme TRM13 homolog (sprot)

A tRNA guanosine-2'-O-methyltransferase TRM13 that is encoded in the genome of human.


aspartate-tRNA ligase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).


negative regulation of ERK1 and ERK2 cascade

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


negative regulation of endodermal cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation.


negative regulation of fibroblast growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.


cytoplasmic side of plasma membrane

The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.


TRADD_HUMAN Tumor necrosis factor receptor type 1-associated DEATH domain protein (sprot)

A tumor necrosis factor receptor type 1-associated DEATH domain protein that is encoded in the genome of human.


FADD_HUMAN FAS-associated death domain protein (sprot)

A FAS-associated death domain protein that is encoded in the genome of human.


positive regulation of antimicrobial peptide production

Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.


non-motile cilium assembly

The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium.


TORC1 signaling

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.


peptidyl-threonine phosphorylation

The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


glucose homeostasis

Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.


peptidyl-serine phosphorylation

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.


mitotic chromosome condensation

The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.


myelination

The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.


positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


protein maturation

Any process leading to the attainment of the full functional capacity of a protein.


ERK1 and ERK2 cascade

A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development.


PERK-mediated unfolded protein response

The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.


antifungal innate immune response

An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.


hippo signaling

An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.


negative regulation of translation

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.


transcription elongation by RNA polymerase II

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.


autophagy

The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation.


autophagosome assembly

The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.


peptidyl-serine autophosphorylation

The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein.


necroptotic process

A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.


renal sodium ion absorption

A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.


cellular response to stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


mitophagy

The selective autophagy process in which a mitochondrion is degraded by macroautophagy.


interstrand cross-link repair

Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.


chemical synaptic transmission

The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


negative regulation of G0 to G1 transition

A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.


activation of protein kinase B activity

Any process that initiates the activity of the inactive enzyme protein kinase B.


double-strand break repair via homologous recombination

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.


cellular response to amino acid starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.


double-strand break repair via nonhomologous end joining

The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.


negative regulation of autophagy

Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


Wnt signaling pathway, planar cell polarity pathway

A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton.


The series of molecular signals initiated by interleukin-17A binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.


cellular response to osmotic stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


positive regulation of translational initiation

Any process that activates or increases the frequency, rate or extent of translational initiation.


sphingolipid biosynthetic process

The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


DNA damage checkpoint signaling

A signal transduction process that contributes to a DNA damage checkpoint.


positive regulation of protein localization to kinetochore

Any process that activates or increases the frequency, rate or extent of protein localization to kinetochore.


activation of innate immune response

Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.


cGAS/STING signaling pathway

The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING.


cell cycle G2/M phase transition

The cell cycle process by which a cell in G2 phase commits to M phase.


negative regulation of innate immune response

Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.


negative regulation of hepatocyte apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process.


Schwann cell development

The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.


sister chromatid cohesion

The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.


positive regulation of mitotic sister chromatid segregation

Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.


protein localization to lipid droplet

A process in which a protein is transported to, or maintained in, a location on or within a lipid droplet.


positive regulation of protein localization to chromatin

Any process that activates or increases the frequency, rate or extent of protein localization to chromatin.


cellular response to epidermal growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.


regulation of DNA-binding transcription factor activity

Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.


meiosis I

The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei.


protein stabilization

Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.


ERBB2-ERBB3 signaling pathway

The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission.


positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.


double-strand break repair

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.


positive regulation of protein export from nucleus

Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.


protein localization to centrosome

A process in which a protein is transported to, or maintained at, the centrosome.


positive regulation of protein localization to endoplasmic reticulum

Any process that activates or increases the frequency, rate or extent of protein localization to endoplasmic reticulum.


positive regulation of lipid biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.


protein destabilization

Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.


positive regulation of autophagy

Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.


response to starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.


virus-mediated perturbation of host defense response

A process in which a virus interferes with the ability of the host to mount a defense in response to its presence. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction.


apical constriction

The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.


execution phase of necroptosis

A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died.


necroptotic signaling pathway

The series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered.


symbiont-mediated suppression of host NF-kappaB cascade

A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


positive regulation of protein localization to nucleus

Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.


symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity

A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.


symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway

A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response.


negative regulation of protein import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.


protein autophosphorylation

The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).


cellular response to UV-B

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.


cellular response to reactive oxygen species

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.


regulation of type B pancreatic cell development

Any process that modulates the frequency, rate or extent of pancreatic B cell development.


positive regulation of NLRP3 inflammasome complex assembly

Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly.


regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.


positive regulation of protein ubiquitination

Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.


regulation of tRNA methylation

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA methylation.


The series of molecular signals initiated by interleukin-33 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


regulation of cardiac conduction

Any process that modulates the frequency, rate or extent of cardiac conduction.


regulation of cellular response to heat

Any process that modulates the frequency, rate or extent of cellular response to heat.


DNA double-strand break processing

The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.


cell volume homeostasis

Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.


mitotic G2 DNA damage checkpoint signaling

A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.


negative regulation of protein localization to lysosome

Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome.


cellular response to methionine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus.


cellular response to nutrient

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.


antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.


positive regulation of neuron projection development

Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).


double-strand break repair via alternative nonhomologous end joining

An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment.


regulation of mRNA stability

Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.


regulation of signal transduction by p53 class mediator

Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.


positive regulation of cGAS/STING signaling pathway

Any process that activates or increases the frequency, rate or extent of of cGAS/STING signaling pathway.


negative regulation of cilium assembly

Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.


mitotic nuclear membrane disassembly

The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.


mitotic G2/M transition checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle.


positive regulation of aggrephagy

Any process that activates or increases the frequency, rate or extent of aggrephagy.


positive regulation of autophagosome assembly

Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.


COPII vesicle coating

The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.


negative regulation of cell growth involved in contact inhibition

The negative regulation of cell growth in response to increased cell density.


positive regulation of hippo signaling

Any process that activates or increases the frequency, rate or extent of hippo signaling.


DNA replication

The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.


platelet activation

A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.


negative regulation of Notch signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.


regulation of insulin secretion

Any process that modulates the frequency, rate or extent of the regulated release of insulin.


regulation of G2/M transition of mitotic cell cycle

Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.


leukotriene metabolic process

The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.


MyD88-dependent toll-like receptor signaling pathway

A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.


lipophagy

The selective degradation of lipid droplets by macroautophagy.


Wnt signaling pathway, calcium modulating pathway

A type of non-canonical Wnt signaling in which Wnt binding to its receptor on the surface of a target cell leads to an increase in intracellular calcium and activation of protein kinase C (PKC).


regulation of eIF2 alpha phosphorylation by heme

Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels.


positive regulation of ubiquitin protein ligase activity

Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity.


regulation of fatty acid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.


regulation of macroautophagy

Any process that modulates the frequency, rate or extent of macroautophagy.


beta-catenin destruction complex disassembly

The disaggregation of a beta-catenin destruction complex into its constituent components.


negative regulation of microtubule binding

Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding.


high-density lipoprotein particle assembly

The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.


positive regulation of tau-protein kinase activity

Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity.


chemokine activity

The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


insulin secretion

The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.


cholesterol binding

Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


Double stranded RNA

A ribonucleic acid with two complementary strands, similar to the DNA found in all cells.


acetyltransferase activity

Catalysis of the transfer of an acetyl group to an acceptor molecule.


S-adenosyl-L-methionine binding

Binding to S-adenosyl-L-methionine.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+.


histone H2AK15 ubiquitin ligase activity

Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-15 residue.


phospholipase C activity

Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.


histone H4K20 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein.


interleukin-17 receptor activity

Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


G protein-coupled estrogen receptor activity

Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


kinase activator activity

Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


peroxisome matrix targeting signal-1 binding

Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L.


store-operated calcium channel activity

A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.


virion binding

Binding to a virion, either by binding to components of the capsid or the viral envelope.


protein serine/threonine kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase.


positive regulation of protein serine/threonine kinase activity

Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.


negative regulation of protein serine/threonine kinase activity

Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.


ubiquitin-protein transferase inhibitor activity

Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase.


Binding to a protein upon phosphorylation of the target protein.


protein farnesyltransferase activity

Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.


protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.


mRNA base-pairing translational repressor activity

A translation repressor activity that acts by base-pairing with an mRNA. The binding can result in targeting the mRNA for degradation or interfering with mRNA translation, hence resulting in posttranscriptional gene silencing.


methionine adenosyltransferase activity

Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.


lysophosphatidic acid receptor activity

Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein.


DNA endonuclease activity

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.


protein serine/threonine/tyrosine kinase activity

Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+.


SUMO transferase activity

Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.


monoatomic cation channel activity

Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient.


DNA nuclease activity

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.


calcium- and calmodulin-responsive adenylate cyclase activity

Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.


endodeoxyribonuclease activity, producing 5'-phosphomonoesters

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.


Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.


DNA clamp loader activity

Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis.


stearoyl-CoA 9-desaturase activity

Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O.


choline kinase activity

Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+.


P-type calcium transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out).


D-erythro-sphingosine kinase activity

Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.


protein localization to phagophore assembly site

Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS).


structural constituent of ribosome

The action of a molecule that contributes to the structural integrity of the ribosome.


histone methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue.


protein-arginine omega-N symmetric methyltransferase activity

Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.


DNA strand exchange activity

Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.


nitric-oxide synthase activity

Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.


DNA-binding transcription factor binding

Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.


phosphatidylethanolamine binding

Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.


phospholipid binding

Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.


JUN kinase kinase activity

Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.


phosphoric diester hydrolase activity

Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.


enzyme inhibitor activity

Binds to and stops, prevents or reduces the activity of an enzyme.


cysteine-type endopeptidase activity involved in apoptotic process

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process.


cysteine-type endopeptidase regulator activity involved in apoptotic process

Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.


endonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.


lipid transporter activity

Enables the directed movement of lipids into, out of or within a cell, or between cells.


kinetochore adaptor activity

The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way.


ethanolamine kinase activity

Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine.


lipid droplet disassembly

The disaggregation of a lipid particle into its constituent components.


thymidine kinase activity

Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.


phosphoenolpyruvate carboxykinase (GTP) activity

Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.


microtubule stabilizing activity

A protein-containing complex stabilizing activity that prevents dissociation of microtubules.


histone chaperone activity

Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone).


Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate.


NAD+- protein-aspartate ADP-ribosyltransferase activity

Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide.


ubiquitin-dependent protein binding

Binding to a protein upon ubiquitination of the target protein.


poly(A)-specific ribonuclease activity

Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.


interleukin-33 receptor activity

Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).


Atg8 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond.


Atg12 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond.


Atg8-family ligase activity

Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 family modifer to phosphatidylethanolamine or phosphatidylserine on a membrane.


ATPase activator activity

Binds to and increases the activity of an ATP hydrolysis activity.


protein serine pyrophosphorylase activity

Catalysis of the reaction: protein phospho-serine + inositol 5-triphosphate pentakisphosphate = protein diphospho-serine + inositol 5-diphosphate pentakisphosphate.


mRNA N6-methyladenosine dioxygenase activity

Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.


structural constituent of nuclear lamina

The action of a molecule that contributes to the structural integrity of nuclear lamina.


GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.


5'-3' DNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule.


3'-5'-DNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.


peptide lactyltransferase activity

Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[protein].


glutathione peroxidase activity

Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.


peptidyl-prolyl cis-trans isomerase activity

Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).


microfilament motor activity

A motor activity that generates movement along a microfilament, driven by ATP hydrolysis.


calcium-dependent protein serine/threonine phosphatase regulator activity

Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase.


leukotriene-C4 synthase activity

Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4).


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.


calcium-dependent phospholipase A2 activity

Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+.


DNA ligase activity

Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+.


glutathione hydrolase activity

Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate.


leukotriene-A4 hydrolase activity

Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4).


Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase].


5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity

Catalysis of the reaction: 5-HETE + NADP+ = 5-oxo-ETE + NADPH + H+.


arachidonate 5-lipoxygenase activity

Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate.


eoxin C4 synthase activity

Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4.


eoxin E4 synthase activity

Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine.


leukotriene B4 12-hydroxy dehydrogenase activity

Catalysis of the reaction: leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+.


eoxin A4 synthase activity

Catalysis of the reaction: leukotriene A4 = eoxin A4.


20-aldehyde-leukotriene B4 20-monooxygenase activity

Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase].


eoxin D4 synthase activity

Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid.


20-hydroxy-leukotriene B4 omega oxidase activity

Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase].


myosin-light-chain-phosphatase activity

Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate.


annealing activity

An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule.


lysine N-methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue.


mRNA guanylyltransferase activity

Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue.


polynucleotide 5'-phosphatase activity

Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate.


ciliary transition zone

A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.


centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.


autophagosome

A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.


endoplasmic reticulum-Golgi intermediate compartment membrane

The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.


endoplasmic reticulum lumen

The volume enclosed by the membranes of the endoplasmic reticulum.


microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.


ciliary tip

Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction.


peroxisomal matrix

The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.


endosome membrane

The lipid bilayer surrounding an endosome.


microtubule organizing center

An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.


Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.


bicellular tight junction

An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.


omegasome membrane

Any membrane that is part of an omegasome.


sarcoplasmic reticulum membrane

The lipid bilayer surrounding the sarcoplasmic reticulum.


meiotic spindle

A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.


The heptaanion of a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate; major species at pH 7.3.


reactive oxygen species

Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.


mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.


mitotic S phase

The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.


meiotic prophase I

The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.


mitotic M phase

A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.


mitotic G1 phase

The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.


mitotic G2 phase

The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.


AKT kinase

A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites.


IL1R1_HUMAN Interleukin-1 receptor type 1 (sprot)

An interleukin-1 receptor type 1 that is encoded in the genome of human.


NDC80_HUMAN Kinetochore protein NDC80 homolog (sprot)

A kinetochore protein NDC80 that is encoded in the genome of human.


CASP6_HUMAN Caspase-6 (sprot)

A caspase-6 that is encoded in the genome of human.


RAD51_HUMAN DNA repair protein RAD51 homolog 1 (sprot)

A DNA repair protein RAD51 homolog 1 that is encoded in the genome of human.


KITH_HUMAN Thymidine kinase, cytosolic (sprot)

A thymidine kinase, cytosolic that is encoded in the genome of human.


AMRA1_HUMAN Activating molecule in BECN1-regulated autophagy protein 1 (sprot)

An activating molecule in BECN1-regulated autophagy protein 1 that is encoded in the genome of human.


NLRP1_HUMAN NACHT, LRR and PYD domains-containing protein 1 (sprot)

A NACHT, LRR and PYD domains-containing protein 1 that is encoded in the genome of human.


MAP4_HUMAN Microtubule-associated protein 4 (sprot)

A microtubule-associated protein 4 that is encoded in the genome of human.


RS6_HUMAN Small ribosomal subunit protein eS6 (sprot)

A small ribosomal subunit protein eS6 that is encoded in the genome of human.


MLKL_HUMAN Mixed lineage kinase domain-like protein (sprot)

A mixed lineage kinase domain-like protein that is encoded in the genome of human.


CASP9_HUMAN Caspase-9 (sprot)

A caspase-9 that is encoded in the genome of human.


KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (sprot)

A ribosomal protein S6 kinase beta-1 that is encoded in the genome of human.


RPTOR_HUMAN Regulatory-associated protein of mTOR (sprot)

A regulatory-associated protein of mTOR that is encoded in the genome of human.


MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (sprot)

A dual specificity mitogen-activated protein kinase kinase 7 that is encoded in the genome of human.


MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 (sprot)

A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of human.


PEX5_HUMAN Peroxisomal targeting signal 1 receptor (sprot)

A peroxisomal targeting signal 1 receptor that is encoded in the genome of human.


PEX2_HUMAN Peroxisome biogenesis factor 2 (sprot)

A peroxisome assembly factor 1 that is encoded in the genome of human.


CEBPB_HUMAN CCAAT/enhancer-binding protein beta (sprot)

A CCAAT/enhancer-binding protein beta that is encoded in the genome of human.


BRCC3_HUMAN Lys-63-specific deubiquitinase BRCC36 (sprot)

A lys-63-specific deubiquitinase BRCC36 that is encoded in the genome of human.


FBX4_HUMAN F-box only protein 4 (sprot)

An F-box only protein 4 that is encoded in the genome of human.


solute carrier family 12 member 3 isoform h3 (human)

A solute carrier family 12 member 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55017-3.


S12A3_HUMAN Solute carrier family 12 member 3 (sprot)

A solute carrier family 12 member 3 that is encoded in the genome of human.


S12A1_HUMAN Solute carrier family 12 member 1 (sprot)

A solute carrier family 12 member 1 that is encoded in the genome of human.


S12A2_HUMAN Solute carrier family 12 member 2 (sprot)

A solute carrier family 12 member 2 that is encoded in the genome of human.


S12A6_HUMAN Solute carrier family 12 member 6 (sprot)

A solute carrier family 12 member 6 that is encoded in the genome of human.


RB1-inducible coiled-coil protein 1 isoform h1 (human)

An RB1-inducible coiled-coil protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TDY2-1.


BAKOR_HUMAN Beclin 1-associated autophagy-related key regulator (sprot)

A beclin 1-associated autophagy-related key regulator that is encoded in the genome of human.


RRAGA_HUMAN Ras-related GTP-binding protein A (sprot)

A Ras-related GTP-binding protein A that is encoded in the genome of human.


KS6B2_HUMAN Ribosomal protein S6 kinase beta-2 (sprot)

A ribosomal protein S6 kinase beta-2 that is encoded in the genome of human.


DEPD5_HUMAN GATOR1 complex protein DEPDC5 (sprot)

A GATOR1 complex protein DEPDC5 that is encoded in the genome of human.


NLK_HUMAN Serine/threonine-protein kinase NLK (sprot)

A serine/threonine-protein kinase NLK that is encoded in the genome of human.


AKTS1_HUMAN Proline-rich AKT1 substrate 1 (sprot)

A proline-rich AKT1 substrate 1 that is encoded in the genome of human.


UBP4_HUMAN Ubiquitin carboxyl-terminal hydrolase 4 (sprot)

A ubiquitin carboxyl-terminal hydrolase 4 that is encoded in the genome of human.


DPTOR_HUMAN DEP domain-containing mTOR-interacting protein (sprot)

A DEP domain-containing mTOR-interacting protein that is encoded in the genome of human.


DEP domain-containing mTOR-interacting protein isoform h2 (human)

A DEP domain-containing mTOR-interacting protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TB45-2.


interferon regulatory factor 7 isoform D (human)

An interferon regulatory factor 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92985-4.


E2AK1_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 1 (sprot)

A eukaryotic translation initiation factor 2-alpha kinase 1 that is encoded in the genome of human.


DPOLQ_HUMAN DNA polymerase theta (sprot)

A DNA polymerase theta that is encoded in the genome of human.


RHNO1_HUMAN RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (sprot)

A RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 that is encoded in the genome of human.


ALKB5_HUMAN RNA demethylase ALKBH5 (sprot)

An alkylated DNA repair protein alkB 5 that is encoded in the genome of human.


CHK1_HUMAN Serine/threonine-protein kinase Chk1 (sprot)

A serine/threonine-protein kinase Chk1 that is encoded in the genome of human.


NEK2_HUMAN Serine/threonine-protein kinase Nek2 (sprot)

A serine/threonine-protein kinase Nek2 that is encoded in the genome of human.


STEEP_HUMAN STING ER exit protein (sprot)

A STING ER exit protein that is encoded in the genome of human.


WEE1_HUMAN Wee1-like protein kinase (sprot)

A Wee1-like protein kinase that is encoded in the genome of human.


CHK2_HUMAN Serine/threonine-protein kinase Chk2 (sprot)

A serine/threonine-protein kinase Chk2 that is encoded in the genome of human.


serine/threonine-protein kinase Chk2 isoform h10 (human)

A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-10.


KIF23_HUMAN Kinesin-like protein KIF23 (sprot)

A kinesin-like protein KIF23 that is encoded in the genome of human.


1433S_HUMAN 14-3-3 protein sigma (sprot)

A 14-3-3 protein sigma that is encoded in the genome of human.


WDR44_HUMAN WD repeat-containing protein 44 (sprot)

A WD repeat-containing protein 44 that is encoded in the genome of human.


RHG26_HUMAN Rho GTPase-activating protein 26 (sprot)

A Rho GTPase-activating protein 26 that is encoded in the genome of human.


NBN_HUMAN Nibrin (sprot)

A nibrin that is encoded in the genome of human.


RAD50_HUMAN DNA repair protein RAD50 (sprot)

A DNA repair protein RAD50 that is encoded in the genome of human.


C1QBP_HUMAN Complement component 1 Q subcomponent-binding protein, mitochondrial (sprot)

A complement component 1 Q subcomponent-binding protein, mitochondrial that is encoded in the genome of human.


EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (sprot)

A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of human.


KALRN_MOUSE Kalirin (sprot)

A kalirin that is encoded in the genome of mouse.


serine/threonine-protein kinase D1 isoform m1 unphosphorylated 1 (mouse)

A serine/threonine-protein kinase D1 isoform m1 (mouse) that lacks phosphorylation at the position equivalent to Ser-203 of the amino acid sequence represented by UniProtKB:Q62101-1. UniProtKB:Q04759-1, Ser-203, PR:000026291.


lipolysis-stimulated lipoprotein receptor isoform m2 unphosphorylated 1 (mouse)

A lipolysis-stimulated lipoprotein receptor isoform m2 (mouse) that lacks phosphorylation at the position equivalent to Ser-288. UniProtKB:Q99KG5-2, Ser-288, PR:000026291.


histone deacetylase 3 isoform Long unphosphorylated 1 (mouse)

A histone deacetylase 3 isoform 1 unphosphorylated 1 in mouse. UniProtKB:O88895-1, Ser-424, PR:000026291.


COF1_HUMAN Cofilin-1 (sprot)

A cofilin-1 that is encoded in the genome of human.


POU domain, class 5, transcription factor 1 isoform 1 unphosphorylated 1 (mouse)

A POU domain, class 5, transcription factor 1 isoform 1 unphosphorylated 1 in mouse. UniProtKB:P20263-1, Thr-228, PR:000026291.


LIMK1_HUMAN LIM domain kinase 1 (sprot)

A LIM domain kinase 1 that is encoded in the genome of human.


MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (sprot)

A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of human.


M3K8_HUMAN Mitogen-activated protein kinase kinase kinase 8 (sprot)

A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of human.


BAD_HUMAN Bcl2-associated agonist of cell death (sprot)

A Bcl2-associated agonist of cell death that is encoded in the genome of human.


KPCD_HUMAN Protein kinase C delta type (sprot)

A protein kinase C delta type that is encoded in the genome of human.


ARBK1_HUMAN Beta-adrenergic receptor kinase 1 (sprot)

A beta-adrenergic receptor kinase 1 that is encoded in the genome of human.


KS6A5_HUMAN Ribosomal protein S6 kinase alpha-5 (sprot)

A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human.


CREB1_HUMAN Cyclic AMP-responsive element-binding protein 1 (sprot)

A cyclic AMP-responsive element-binding protein 1 that is encoded in the genome of human.


SGK1_HUMAN Serine/threonine-protein kinase Sgk1 (sprot)

A serine/threonine-protein kinase Sgk1 that is encoded in the genome of human.


PA24A_HUMAN Cytosolic phospholipase A2 (sprot)

A cytosolic phospholipase A2 that is encoded in the genome of human.


EAF2_HUMAN ELL-associated factor 2 (sprot)

An ELL-associated factor 2 that is encoded in the genome of human.


AF9_HUMAN Protein AF-9 (sprot)

A protein AF-9 that is encoded in the genome of human.


EAF1_HUMAN ELL-associated factor 1 (sprot)

An ELL-associated factor 1 that is encoded in the genome of human.


ENL_HUMAN Protein ENL (sprot)

A protein ENL that is encoded in the genome of human.


ELL_HUMAN RNA polymerase II elongation factor ELL (sprot)

An RNA polymerase II elongation factor ELL that is encoded in the genome of human.


AFF4_HUMAN AF4/FMR2 family member 4 (sprot)

An AF4/FMR2 family member 4 that is encoded in the genome of human.


KPCB_HUMAN Protein kinase C beta type (sprot)

A protein kinase C beta type that is encoded in the genome of human.


FOXO3_HUMAN Forkhead box protein O3 (sprot)

A forkhead box protein O3 that is encoded in the genome of human.


KPCZ_HUMAN Protein kinase C zeta type (sprot)

A protein kinase C zeta type that is encoded in the genome of human.


SNP23_HUMAN Synaptosomal-associated protein 23 (sprot)

A synaptosomal-associated protein 23 that is encoded in the genome of human.


HIF1A_HUMAN Hypoxia-inducible factor 1-alpha (sprot)

A hypoxia-inducible factor 1-alpha that is encoded in the genome of human.


BRAF_HUMAN Serine/threonine-protein kinase B-raf (sprot)

A B-Raf proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human.


UBP8_HUMAN Ubiquitin carboxyl-terminal hydrolase 8 (sprot)

A ubiquitin carboxyl-terminal hydrolase 8 that is encoded in the genome of human.


TBCD1_HUMAN TBC1 domain family member 1 (sprot)

A TBC1 domain family member 1 that is encoded in the genome of human.


STA10_HUMAN START domain-containing protein 10 (sprot)

A START domain-containing protein 10 that is encoded in the genome of human.


PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (sprot)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase that is encoded in the genome of human.


PDE3B_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (sprot)

A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B that is encoded in the genome of human.


EF2K_HUMAN Eukaryotic elongation factor 2 kinase (sprot)

An elongation factor 2 kinase that is encoded in the genome of human.


IF4G1_HUMAN Eukaryotic translation initiation factor 4 gamma 1 (sprot)

A eukaryotic translation initiation factor 4 gamma 1 that is encoded in the genome of human.


IF4B_HUMAN Eukaryotic translation initiation factor 4B (sprot)

A eukaryotic translation initiation factor 4B that is encoded in the genome of human.


ceramide transfer protein isoform CERT (human)

A ceramide transfer protein isoform CERT that is encoded in the genome of human.


FBX5_HUMAN F-box only protein 5 (sprot)

An F-box only protein 5 that is encoded in the genome of human.


NOTC4_HUMAN Neurogenic locus notch homolog protein 4 (sprot)

A neurogenic locus notch homolog protein 4 that is encoded in the genome of human.


NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (sprot)

A nuclear receptor subfamily 4 immunity group A member 1 that is encoded in the genome of human.


ELK1_HUMAN ETS domain-containing protein Elk-1 (sprot)

An ETS domain-containing protein Elk-1 that is encoded in the genome of human.


MAPK2_HUMAN MAP kinase-activated protein kinase 2 (sprot)

A MAP kinase-activated protein kinase 2 that is encoded in the genome of human.


ATF1_HUMAN Cyclic AMP-dependent transcription factor ATF-1 (sprot)

A cyclic AMP-dependent transcription factor ATF-1 that is encoded in the genome of human.


NCOA3_HUMAN Nuclear receptor coactivator 3 (sprot)

A nuclear receptor coactivator 3 that is encoded in the genome of human.


DVL2_HUMAN Segment polarity protein dishevelled homolog DVL-2 (sprot)

A segment polarity protein dishevelled homolog DVL-2 that is encoded in the genome of human.


PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (sprot)

A serine/threonine-protein kinase PAK 1 that is encoded in the genome of human.


ARP19_HUMAN cAMP-regulated phosphoprotein 19 (sprot)

A cAMP-regulated phosphoprotein 19 that is encoded in the genome of human.


ENSA_HUMAN Alpha-endosulfine (sprot)

An alpha-endosulfine that is encoded in the genome of human.


ETS1_HUMAN Protein C-ets-1 (sprot)

A protein C-ets-1 that is encoded in the genome of human.


ERF_HUMAN ETS domain-containing transcription factor ERF (sprot)

An ETS domain-containing transcription factor ERF that is encoded in the genome of human.


ETS2_HUMAN Protein C-ets-2 (sprot)

A protein C-ets-2 that is encoded in the genome of human.


FOS_HUMAN Protein c-Fos (sprot)

A protein c-Fos that is encoded in the genome of human.


MAPK5_HUMAN MAP kinase-activated protein kinase 5 (sprot)

A MAP kinase-activated protein kinase 5 that is encoded in the genome of human.


ATF2_HUMAN Cyclic AMP-dependent transcription factor ATF-2 (sprot)

A cyclic AMP-dependent transcription factor ATF-2 that is encoded in the genome of human.


HSF1_HUMAN Heat shock factor protein 1 (sprot)

A heat shock factor protein 1 that is encoded in the genome of human.


CCAR2_HUMAN Cell cycle and apoptosis regulator protein 2 (sprot)

A cell cycle and apoptosis regulator protein 2 that is encoded in the genome of human.


L1CAM_HUMAN Neural cell adhesion molecule L1 (sprot)

A neural cell adhesion molecule L1 that is encoded in the genome of human.


GSK3A_HUMAN Glycogen synthase kinase-3 alpha (sprot)

A glycogen synthase kinase-3 alpha that is encoded in the genome of human.


NPM_HUMAN Nucleophosmin (sprot)

A nucleophosmin that is encoded in the genome of human.


RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (sprot)

A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human.


ML12A_HUMAN Myosin regulatory light chain 12A (sprot)

A myosin regulatory light chain MRLC3 that is encoded in the genome of human.


MARCS_HUMAN Myristoylated alanine-rich C-kinase substrate (sprot)

A myristoylated alanine-rich C-kinase substrate that is encoded in the genome of human.


MYLK_HUMAN Myosin light chain kinase, smooth muscle (sprot)

A myosin light chain kinase, smooth muscle that is encoded in the genome of human.


FUBP2_HUMAN Far upstream element-binding protein 2 (sprot)

A far upstream element-binding protein 2 that is encoded in the genome of human.


DVL1_HUMAN Segment polarity protein dishevelled homolog DVL-1 (sprot)

A segment polarity protein dishevelled homolog DVL-1 that is encoded in the genome of human.


TFE2_HUMAN Transcription factor E2-alpha (sprot)

A transcription factor E2-alpha that is encoded in the genome of human.


GLI3_HUMAN Transcriptional activator GLI3 (sprot)

A transcriptional activator GLI3 that is encoded in the genome of human.


GLI1_HUMAN Zinc finger protein GLI1 (sprot)

A zinc finger protein GLI1 that is encoded in the genome of human.


GLI2_HUMAN Zinc finger protein GLI2 (sprot)

A zinc finger protein GLI2 that is encoded in the genome of human.


PP14A_HUMAN Protein phosphatase 1 regulatory subunit 14A (sprot)

A protein phosphatase 1 regulatory subunit 14A that is encoded in the genome of human.


PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (sprot)

A serine/threonine-protein kinase PAK 3 that is encoded in the genome of human.


SRC8_HUMAN Src substrate cortactin (sprot)

A Src substrate cortactin that is encoded in the genome of human.


SRF_HUMAN Serum response factor (sprot)

A serum response factor that is encoded in the genome of human.


VCIP1_HUMAN Deubiquitinating protein VCPIP1 (sprot)

A deubiquitinating protein VCPIP1 that is encoded in the genome of human.


MK06_HUMAN Mitogen-activated protein kinase 6 (sprot)

A mitogen-activated protein kinase 6 that is encoded in the genome of human.


MK04_HUMAN Mitogen-activated protein kinase 4 (sprot)

A mitogen-activated protein kinase 4 that is encoded in the genome of human.


DCR1C_HUMAN Protein artemis (sprot)

A protein artemis that is encoded in the genome of human.


NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (sprot)

A histone-lysine N-methyltransferase NSD2 that is encoded in the genome of human.


PIDD1_HUMAN p53-induced death domain-containing protein 1 (sprot)

A p53-induced death domain-containing protein 1 that is encoded in the genome of human.


CENPJ_HUMAN Centromere protein J (sprot)

A centromere protein J that is encoded in the genome of human.


PHF20_HUMAN PHD finger protein 20 (sprot)

A PHD finger protein 20 that is encoded in the genome of human.


TTC5_HUMAN Tetratricopeptide repeat protein 5 (sprot)

A tetratricopeptide repeat protein 5 that is encoded in the genome of human.


DYRK2_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 2 (sprot)

A dual specificity tyrosine-phosphorylation-regulated kinase 2 that is encoded in the genome of human.


NUAK1_HUMAN NUAK family SNF1-like kinase 1 (sprot)

A NUAK family SNF1-like kinase 1 that is encoded in the genome of human.


PHLP_HUMAN Phosducin-like protein (sprot)

A phosducin-like protein that is encoded in the genome of human.


ZN420_HUMAN Zinc finger protein 420 (sprot)

A zinc finger protein 420 that is encoded in the genome of human.


KI20A_HUMAN Kinesin-like protein KIF20A (sprot)

A kinesin-like protein KIF20A that is encoded in the genome of human.


DEND3_HUMAN DENN domain-containing protein 3 (sprot)

A DENN domain-containing protein 3 that is encoded in the genome of human.


FUND1_HUMAN FUN14 domain-containing protein 1 (sprot)

A FUN14 domain-containing protein 1 that is encoded in the genome of human.


MAF1_HUMAN Repressor of RNA polymerase III transcription MAF1 homolog (sprot)

A repressor of RNA polymerase III transcription MAF1 that is encoded in the genome of human.


E2F6_HUMAN Transcription factor E2F6 (sprot)

A transcription factor E2F6 that is encoded in the genome of human.


MEF2C_HUMAN Myocyte-specific enhancer factor 2C (sprot)

A myocyte-specific enhancer factor 2C that is encoded in the genome of human.


MEF2D_HUMAN Myocyte-specific enhancer factor 2D (sprot)

A myocyte-specific enhancer factor 2D that is encoded in the genome of human.


microtubule-associated protein tau isoform Tau-F (human)

A microtubule-associated protein tau isoform Tau-F that is encoded in the genome of human.


FOXO6_HUMAN Forkhead box protein O6 (sprot)

A forkhead box protein O6 that is encoded in the genome of human.


NUDC_HUMAN Nuclear migration protein nudC (sprot)

A nuclear migration protein nudC that is encoded in the genome of human.


GTPase KRas isoform 2B (human)

A GTPase KRas isoform 2 that is encoded in the genome of human.


NPAS4_HUMAN Neuronal PAS domain-containing protein 4 (sprot)

A neuronal PAS domain-containing protein 4 that is encoded in the genome of human.


EYA2_HUMAN Eyes absent homolog 2 (sprot)

An eyes absent homolog 2 that is encoded in the genome of human.


BORG1_HUMAN Cdc42 effector protein 2 (sprot)

A Cdc42 effector protein 2 that is encoded in the genome of human.


KS6A4_HUMAN Ribosomal protein S6 kinase alpha-4 (sprot)

A ribosomal protein S6 kinase alpha-4 that is encoded in the genome of human.


EYA4_HUMAN Eyes absent homolog 4 (sprot)

An eyes absent homolog 4 that is encoded in the genome of human.


methyl-CpG-binding protein 2 isoform 1 (human)

A methyl-CpG-binding protein 2 isoform 1 that is encoded in the genome of human.


methyl-CpG-binding protein 2 isoform 2 (human)

A methyl-CpG-binding protein 2 isoform 2 that is encoded in the genome of human.


KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (sprot)

A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of human.


LIMK2_HUMAN LIM domain kinase 2 (sprot)

A LIM domain kinase 2 that is encoded in the genome of human.


MEF2A_HUMAN Myocyte-specific enhancer factor 2A (sprot)

A myocyte-specific enhancer factor 2A that is encoded in the genome of human.


MEF2B_HUMAN Myocyte-specific enhancer factor 2B (sprot)

A myocyte-specific enhancer factor 2B that is encoded in the genome of human.


KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 (sprot)

A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human.


KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 (sprot)

A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human.


MAPK3_HUMAN MAP kinase-activated protein kinase 3 (sprot)

A MAP kinase-activated protein kinase 3 that is encoded in the genome of human.


BORG3_HUMAN Cdc42 effector protein 5 (sprot)

A Cdc42 effector protein 5 that is encoded in the genome of human.


DEN1B_HUMAN DENN domain-containing protein 1B (sprot)

A DENN domain-containing protein 1B that is encoded in the genome of human.


DEN1A_HUMAN DENN domain-containing protein 1A (sprot)

A DENN domain-containing protein 1A that is encoded in the genome of human.


DVL3_HUMAN Segment polarity protein dishevelled homolog DVL-3 (sprot)

A segment polarity protein dishevelled DVL-3 that is encoded in the genome of human.


EYA1_HUMAN Eyes absent homolog 1 (sprot)

An eyes absent homolog 1 that is encoded in the genome of human.


EYA3_HUMAN Eyes absent homolog 3 (sprot)

An eyes absent homolog 3 that is encoded in the genome of human.


KS6A6_HUMAN Ribosomal protein S6 kinase alpha-6 (sprot)

A ribosomal protein S6 kinase alpha-6 that is encoded in the genome of human.


BORG2_HUMAN Cdc42 effector protein 3 (sprot)

A Cdc42 effector protein 3 that is encoded in the genome of human.


SC23A_HUMAN Protein transport protein Sec23A (sprot)

A protein transport protein Sec23A that is encoded in the genome of human.


POU domain, class 5, transcription factor 1 isoform 1 phosphorylated 1 (mouse)

A POU domain, class 5, transcription factor 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P20263-1, Thr-228, MOD:00047.


vasodilator-stimulated phosphoprotein phosphorylated 1 (mouse)

A vasodilator-stimulated phosphoprotein (mouse) that has been phosphorylated on a Ser residue equivalent to Ser-153 of the amino acid sequence represented by UniProtKB:P70460. UniProtKB:P70460, Ser-153, MOD:00046.


serine/threonine-protein kinase D1 isoform m1 phosphorylated 1 (mouse)

A serine/threonine-protein kinase D1 isoform m1 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-203 of the amino acid sequence represented by UniProtKB:Q62101-1. UniProtKB:Q04759-1, Ser-203, MOD:00046.


lipolysis-stimulated lipoprotein receptor isoform m2 phosphorylated 1 (mouse)

A lipolysis-stimulated lipoprotein receptor isoform m2 (mouse) that is phosphorylated on the residue at the position equivalent to Ser-288. UniProtKB:Q99KG5-2, Ser-288, MOD:00046.


histone deacetylase 3 isoform Long phosphorylated 1 (mouse)

A histone deacetylase 3 isoform 1 phosphorylated 1 in mouse. UniProtKB:O88895-1, Ser-424, MOD:00046.


B2L11_HUMAN Bcl-2-like protein 11 (sprot)

A Bcl-2-like protein 11 that is encoded in the genome of human.


BMF_HUMAN Bcl-2-modifying factor (sprot)

A Bcl-2-modifying factor that is encoded in the genome of human.


CLSPN_HUMAN Claspin (sprot)

A claspin that is encoded in the genome of human.


AKT2_HUMAN RAC-beta serine/threonine-protein kinase (sprot)

A RAC-beta serine/threonine-protein kinase that is encoded in the genome of human.


BORA_HUMAN Protein aurora borealis (sprot)

A protein aurora borealis that is encoded in the genome of human.


STK11_HUMAN Serine/threonine-protein kinase STK11 (sprot)

A serine/threonine-protein kinase STK11 that is encoded in the genome of human.


HS90A_HUMAN Heat shock protein HSP 90-alpha (sprot)

A heat shock protein HSP 90-alpha that is encoded in the genome of human.


OPTN_HUMAN Optineurin (sprot)

An optineurin that is encoded in the genome of human.


AJUBA_HUMAN LIM domain-containing protein ajuba (sprot)

A protein ajuba that is encoded in the genome of human.


TEBP_HUMAN Prostaglandin E synthase 3 (sprot)

A prostaglandin E synthase 3 that is encoded in the genome of human.


FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4 (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP4 that is encoded in the genome of human.


2A5B_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (sprot)

A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform that is encoded in the genome of human.


PPP5_HUMAN Serine/threonine-protein phosphatase 5 (sprot)

A serine/threonine-protein phosphatase 5 that is encoded in the genome of human.


SC24C_HUMAN Protein transport protein Sec24C (sprot)

A protein transport protein Sec24C that is encoded in the genome of human.


T53I1_HUMAN Tumor protein p53-inducible nuclear protein 1 (sprot)

A tumor protein p53-inducible nuclear protein 1 that is encoded in the genome of human.


IEX1_HUMAN Radiation-inducible immediate-early gene IEX-1 (sprot)

A radiation-inducible immediate-early gene IEX-1 that is encoded in the genome of human.


GTSE1_HUMAN G2 and S phase-expressed protein 1 (sprot)

A G2 and S phase-expressed protein 1 that is encoded in the genome of human.


HS90B_HUMAN Heat shock protein HSP 90-beta (sprot)

A heat shock protein HSP 90-beta that is encoded in the genome of human.


PHLA1_HUMAN Pleckstrin homology-like domain family A member 1 (sprot)

A pleckstrin homology-like domain family A member 1 that is encoded in the genome of human.


SC24D_HUMAN Protein transport protein Sec24D (sprot)

A protein transport protein Sec24D that is encoded in the genome of human.


SC24A_HUMAN Protein transport protein Sec24A (sprot)

A protein transport protein Sec24A that is encoded in the genome of human.


SC24B_HUMAN Protein transport protein Sec24B (sprot)

A protein transport protein Sec24B that is encoded in the genome of human.


nuclear pore complex protein Nup98-Nup96 isoform h3 (human)

A nuclear pore complex protein Nup98-Nup96 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P52948-3.


nuclear pore complex protein Nup98-Nup96 isoform h4 (human)

A nuclear pore complex protein Nup98-Nup96 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P52948-4.


PPID_HUMAN Peptidyl-prolyl cis-trans isomerase D (sprot)

A eukaryotic-type peptidyl-prolyl cis-trans isomerase D that is encoded in the genome of human.


2A5G_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (sprot)

A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform that is encoded in the genome of human.


IKBB_HUMAN NF-kappa-B inhibitor beta (sprot)

An NF-kappa-B inhibitor beta that is encoded in the genome of human.


AKT3_HUMAN RAC-gamma serine/threonine-protein kinase (sprot)

A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of human.


AVR2A_HUMAN Activin receptor type-2A (sprot)

An activin receptor type-2A that is encoded in the genome of human.


AURKB_HUMAN Aurora kinase B (sprot)

An aurora kinase B that is encoded in the genome of human.


5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform h2 (human)

A 5'-AMP-activated protein kinase catalytic subunit alpha-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13131-2.


VRK1_HUMAN Serine/threonine-protein kinase VRK1 (sprot)

A serine/threonine-protein kinase VRK1 that is encoded in the genome of human.


DYR1A_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1A (sprot)

A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of human.


MARK4_HUMAN MAP/microtubule affinity-regulating kinase 4 (sprot)

A MAP/microtubule affinity-regulating kinase 4 that is encoded in the genome of human.


NEK9_HUMAN Serine/threonine-protein kinase Nek9 (sprot)

A serine/threonine-protein kinase Nek9 that is encoded in the genome of human.


WNK4_HUMAN Serine/threonine-protein kinase WNK4 (sprot)

A serine/threonine-protein kinase WNK4 that is encoded in the genome of human.


WNK1_HUMAN Serine/threonine-protein kinase WNK1 (sprot)

A serine/threonine-protein kinase WNK1 that is encoded in the genome of human.


PIM1_HUMAN Serine/threonine-protein kinase pim-1 (sprot)

A proto-oncogene serine/threonine-protein kinase Pim-1 that is encoded in the genome of human.


KPCI_HUMAN Protein kinase C iota type (sprot)

A protein kinase C iota type that is encoded in the genome of human.


mitogen-activated protein kinase kinase kinase 7 isoform h1D (human)

A mitogen-activated protein kinase kinase kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43318-4.


PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial (sprot)

A serine/threonine-protein kinase PINK1, mitochondrial that is encoded in the genome of human.


cGMP-dependent protein kinase 1 isoform Alpha (mouse)

A cGMP-dependent protein kinase 1 isoform 1 that is encoded in the genome of mouse.


cyclin-dependent kinase 20 isoform 1 (mouse)

A cyclin-dependent kinase 20 isoform 1 that is encoded in the genome of mouse.


PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (sprot)

A 3-phosphoinositide-dependent protein kinase 1 that is encoded in the genome of human.


PLK3_HUMAN Serine/threonine-protein kinase PLK3 (sprot)

A serine/threonine-protein kinase PLK3 that is encoded in the genome of human.


MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 (sprot)

A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of human.


MKNK1_HUMAN MAP kinase-interacting serine/threonine-protein kinase 1 (sprot)

A MAP kinase-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human.


ACV1C_HUMAN Activin receptor type-1C (sprot)

An activin receptor type-1C that is encoded in the genome of human.


ACV1B_HUMAN Activin receptor type-1B (sprot)

An activin receptor type-1B that is encoded in the genome of human.


M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 (sprot)

A mitogen-activated protein kinase kinase kinase 1 that is encoded in the genome of human.


KC1G2_HUMAN Casein kinase I isoform gamma-2 (sprot)

A casein kinase I isoform gamma-2 that is encoded in the genome of human.


CDK5_HUMAN Cyclin-dependent kinase 5 (sprot)

A cyclin-dependent kinase 5 that is encoded in the genome of human.


MK07_HUMAN Mitogen-activated protein kinase 7 (sprot)

A mitogen-activated protein kinase 7 that is encoded in the genome of human.


GWL_HUMAN Serine/threonine-protein kinase greatwall (sprot)

A microtubule-associated serine/threonine-protein kinase-like that is encoded in the genome of human.


FA20C_HUMAN Extracellular serine/threonine protein kinase FAM20C (sprot)

An extracellular serine/threonine protein kinase Fam20C that is encoded in the genome of human.


HIPK2_HUMAN Homeodomain-interacting protein kinase 2 (sprot)

A homeodomain-interacting protein kinase 2 that is encoded in the genome of human.


PKN1_HUMAN Serine/threonine-protein kinase N1 (sprot)

A serine/threonine-protein kinase N1 that is encoded in the genome of human.


ULK3_HUMAN Serine/threonine-protein kinase ULK3 (sprot)

A serine/threonine-protein kinase ULK3 that is encoded in the genome of human.


PLK2_HUMAN Serine/threonine-protein kinase PLK2 (sprot)

A serine/threonine-protein kinase PLK2 that is encoded in the genome of human.


TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (sprot)

A transcription initiation factor TFIID subunit 1 that is encoded in the genome of human.


PRPK_HUMAN EKC/KEOPS complex subunit TP53RK (sprot)

An EKC/KEOPS complex subunit TP53RK that is encoded in the genome of human.


AAK1_HUMAN AP2-associated protein kinase 1 (sprot)

An AAK1 gene translation product (human), isoforms h1 and h2.


PPM1D_HUMAN Protein phosphatase 1D (sprot)

A protein phosphatase 1D that is encoded in the genome of human.


UHMK1_HUMAN Serine/threonine-protein kinase Kist (sprot)

A serine/threonine-protein kinase Kist that is encoded in the genome of human.


PRKX_HUMAN cAMP-dependent protein kinase catalytic subunit PRKX (sprot)

A serine/threonine-protein kinase PRKX that is encoded in the genome of human.


MK10_HUMAN Mitogen-activated protein kinase 10 (sprot)

A mitogen-activated protein kinase 10 that is encoded in the genome of human.


cGMP-dependent protein kinase 1 isoform Alpha (human)

A cGMP-dependent protein kinase 1 isoform 1 that is encoded in the genome of human.


serine/threonine-protein kinase VRK2 isoform h2 (human)

A serine/threonine-protein kinase VRK2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86Y07-2.


NEK6_HUMAN Serine/threonine-protein kinase Nek6 (sprot)

A serine/threonine-protein kinase Nek6 that is encoded in the genome of human.


IL1AP_HUMAN Interleukin-1 receptor accessory protein (sprot)

An interleukin-1 receptor accessory protein that is encoded in the genome of human.


FURIN_HUMAN Furin (sprot)

A furin that is encoded in the genome of human.


TYOBP_HUMAN TYRO protein tyrosine kinase-binding protein (sprot)

A TYRO protein tyrosine kinase-binding protein that is encoded in the genome of human.


VAV3_HUMAN Guanine nucleotide exchange factor VAV3 (sprot)

A guanine nucleotide exchange factor VAV3 that is encoded in the genome of human.


ERBB2_HUMAN Receptor tyrosine-protein kinase erbB-2 (sprot)

A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of human.


KMT5A_HUMAN N-lysine methyltransferase KMT5A (sprot)

An N-lysine methyltransferase KMT5A that is encoded in the genome of human.


NPRL2_HUMAN GATOR1 complex protein NPRL2 (sprot)

A GATOR1 complex protein NPRL2 that is encoded in the genome of human.


ANGT_HUMAN Angiotensinogen (sprot)

An angiotensinogen that is encoded in the genome of human.


I17RA_HUMAN Interleukin-17 receptor A (sprot)

An interleukin-17 receptor A that is encoded in the genome of human.


IL17_HUMAN Interleukin-17A (sprot)

An interleukin-17A that is encoded in the genome of human.


NS8_SARS2 ORF8 protein (sprot)

A protein that is a translation product of the ORF8 gene in SARS-CoV-2.


I17RC_HUMAN Interleukin-17 receptor C (sprot)

An interleukin-17 receptor C that is encoded in the genome of human.


PG062_VACCW Phosphoprotein OPG062 (sprot)


INS_HUMAN Insulin (sprot)

An insulin gene translation product that is encoded in the genome of human.


ZAP70_HUMAN Tyrosine-protein kinase ZAP-70 (sprot)

A tyrosine-protein kinase ZAP-70 that is encoded in the genome of human.


PEX14_HUMAN Peroxisomal membrane protein PEX14 (sprot)

A peroxisomal membrane protein PEX14 that is encoded in the genome of human.


PEX13_HUMAN Peroxisomal membrane protein PEX13 (sprot)

A peroxisomal membrane protein PEX13 that is encoded in the genome of human.


PEX10_HUMAN Peroxisome biogenesis factor 10 (sprot)

A peroxisome biogenesis factor 10 that is encoded in the genome of human.


PEX12_HUMAN Peroxisome assembly protein 12 (sprot)

A peroxisome assembly protein 12 that is encoded in the genome of human.


SN_HUMAN Sialoadhesin (sprot)

A sialoadhesin that is encoded in the genome of human.


OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (sprot)

A UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit that is encoded in the genome of human.