CEP63_HUMAN Centrosomal protein of 63 kDa (sprot)

A centrosomal protein of 63 kDa that is encoded in the genome of human.


ILRL1_HUMAN Interleukin-1 receptor-like 1 (sprot)

An interleukin-1 receptor-like 1 that is encoded in the genome of human.


KLHL3_HUMAN Kelch-like protein 3 (sprot)

A kelch-like protein 3 that is encoded in the genome of human.


RN152_HUMAN E3 ubiquitin-protein ligase RNF152 (sprot)

An E3 ubiquitin-protein ligase RNF152 that is encoded in the genome of human.


LTOR1_HUMAN Ragulator complex protein LAMTOR1 (sprot)

A ragulator complex protein LAMTOR1 that is encoded in the genome of human.


Ragulator complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified).


KICSTOR complex

A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2.


SRMS_HUMAN Tyrosine-protein kinase Srms (sprot)

A tyrosine-protein kinase Srms that is encoded in the genome of human.


OTUB1_HUMAN Ubiquitin thioesterase OTUB1 (sprot)

A ubiquitin thioesterase OTUB1 that is encoded in the genome of human.


ATX3_HUMAN Ataxin-3 (sprot)

An ataxin-3 that is encoded in the genome of human.


SAMTR_HUMAN S-adenosylmethionine sensor upstream of mTORC1 (sprot)

An S-adenosylmethionine sensor upstream of mTORC1 that is encoded in the genome of human.


LYCHS_HUMAN Lysosomal cholesterol signaling protein (sprot)

A lysosomal cholesterol signaling protein that is encoded in the genome of human.


1433G_HUMAN 14-3-3 protein gamma (sprot)

A 14-3-3 protein gamma that is encoded in the genome of human.


R144A_HUMAN E3 ubiquitin-protein ligase RNF144A (sprot)

An E3 ubiquitin-protein ligase RNF144A that is encoded in the genome of human.


ECT2_HUMAN Protein ECT2 (sprot)

A protein ECT2 that is encoded in the genome of human.


METK2_HUMAN S-adenosylmethionine synthase isoform type-2 (sprot)

An S-adenosylmethionine synthetase isoform type-2 that is encoded in the genome of human.


LPAR1_HUMAN Lysophosphatidic acid receptor 1 (sprot)

A lysophosphatidic acid receptor 1 that is encoded in the genome of human.


PREB_HUMAN Prolactin regulatory element-binding protein (sprot)

A prolactin regulatory element-binding protein that is encoded in the genome of human.


SKP2_HUMAN S-phase kinase-associated protein 2 (sprot)

An S-phase kinase-associated protein 2 that is encoded in the genome of human.


LCK_HUMAN Tyrosine-protein kinase Lck (sprot)

A tyrosine-protein kinase Lck that is encoded in the genome of human.


GPR75_HUMAN Probable G-protein coupled receptor 75 (sprot)

A probable G-protein coupled receptor 75 that is encoded in the genome of human.


TRIO_HUMAN Triple functional domain protein (sprot)

A triple functional domain protein that is encoded in the genome of human.


DOCK1_HUMAN Dedicator of cytokinesis protein 1 (sprot)

A dedicator of cytokinesis protein 1 that is encoded in the genome of human.


FAK1_HUMAN Focal adhesion kinase 1 (sprot)

A focal adhesion kinase 1 that is encoded in the genome of human.


SOS1_HUMAN Son of sevenless homolog 1 (sprot)

A son of sevenless homolog 1 that is encoded in the genome of human.


VAV2_HUMAN Guanine nucleotide exchange factor VAV2 (sprot)

A guanine nucleotide exchange factor VAV2 that is encoded in the genome of human.


BTK_HUMAN Tyrosine-protein kinase BTK (sprot)

A tyrosine-protein kinase BTK that is encoded in the genome of human.


RPGF1_HUMAN Rap guanine nucleotide exchange factor 1 (sprot)

A Rap guanine nucleotide exchange factor 1 that is encoded in the genome of human.


GNDS_HUMAN Ral guanine nucleotide dissociation stimulator (sprot)

A Ral guanine nucleotide dissociation stimulator that is encoded in the genome of human.


MCF2_HUMAN Proto-oncogene DBL (sprot)

A proto-oncogene DBL that is encoded in the genome of human.


TIAM2_HUMAN Rho guanine nucleotide exchange factor TIAM2 (sprot)

A Rho guanine nucleotide exchange factor TIAM2 that is encoded in the genome of human.


PI51B_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (sprot)

A phosphatidylinositol 4-phosphate 5-kinase type-1 beta that is encoded in the genome of human.


NGEF_HUMAN Ephexin-1 (sprot)

An ephexin-1 that is encoded in the genome of human.


P2RY1_HUMAN P2Y purinoceptor 1 (sprot)

A P2Y purinoceptor 1 that is encoded in the genome of human.


TIAM1_HUMAN Rho guanine nucleotide exchange factor TIAM1 (sprot)

A Rho guanine nucleotide exchange factor TIAM1 that is encoded in the genome of human.


ARHG7_HUMAN Rho guanine nucleotide exchange factor 7 (sprot)

A Rho guanine nucleotide exchange factor 7 that is encoded in the genome of human.


KALRN_HUMAN Kalirin (sprot)

A kalirin that is encoded in the genome of human.


ITSN1_HUMAN Intersectin-1 (sprot)

An intersectin-1 that is encoded in the genome of human.


ARG28_HUMAN Rho guanine nucleotide exchange factor 28 (sprot)

A Rho guanine nucleotide exchange factor 28 that is encoded in the genome of human.


ARHGC_HUMAN Rho guanine nucleotide exchange factor 12 (sprot)

A Rho guanine nucleotide exchange factor 12 that is encoded in the genome of human.


FGR_HUMAN Tyrosine-protein kinase Fgr (sprot)

A tyrosine-protein kinase Fgr that is encoded in the genome of human.


ARHG6_HUMAN Rho guanine nucleotide exchange factor 6 (sprot)

A Rho guanine nucleotide exchange factor 6 that is encoded in the genome of human.


PI51C_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (sprot)

A phosphatidylinositol 4-phosphate 5-kinase type-1 gamma that is encoded in the genome of human.


serine/threonine-protein phosphatase PGAM5, mitochondrial isoform h2 (human)

A serine/threonine-protein phosphatase PGAM5, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96HS1-2.


ZDHC8_HUMAN Palmitoyltransferase ZDHHC8 (sprot)

A palmitoyltransferase ZDHHC8 that is encoded in the genome of human.


FACE2_HUMAN CAAX prenyl protease 2 (sprot)

A CAAX prenyl protease 2 that is encoded in the genome of human.


YES_HUMAN Tyrosine-protein kinase Yes (sprot)

A tyrosine-protein kinase Yes that is encoded in the genome of human.


ARH37_HUMAN Rho guanine nucleotide exchange factor 37 (sprot)

A Rho guanine nucleotide exchange factor 37 that is encoded in the genome of human.


ARG35_HUMAN Rho guanine nucleotide exchange factor 35 (sprot)

A Rho guanine nucleotide exchange factor 35 that is encoded in the genome of human.


ARG33_HUMAN Rho guanine nucleotide exchange factor 33 (sprot)

A Rho guanine nucleotide exchange factor 33 that is encoded in the genome of human.


RGRF2_HUMAN Ras-specific guanine nucleotide-releasing factor 2 (sprot)

A Ras-specific guanine nucleotide-releasing factor 2 that is encoded in the genome of human.


ARHGA_HUMAN Rho guanine nucleotide exchange factor 10 (sprot)

A Rho guanine nucleotide exchange factor 10 that is encoded in the genome of human.


MCF2L_HUMAN Guanine nucleotide exchange factor DBS (sprot)

A guanine nucleotide exchange factor DBS that is encoded in the genome of human.


ARHGB_HUMAN Rho guanine nucleotide exchange factor 11 (sprot)

A Rho guanine nucleotide exchange factor 11 that is encoded in the genome of human.


ARHG9_HUMAN Rho guanine nucleotide exchange factor 9 (sprot)

A Rho guanine nucleotide exchange factor 9 that is encoded in the genome of human.


PKHG5_HUMAN Pleckstrin homology domain-containing family G member 5 (sprot)

A pleckstrin homology domain-containing family G member 5 that is encoded in the genome of human.


ARHGF_HUMAN Rho guanine nucleotide exchange factor 15 (sprot)

A Rho guanine nucleotide exchange factor 15 that is encoded in the genome of human.


ARAF_HUMAN Serine/threonine-protein kinase A-Raf (sprot)

A serine/threonine-protein kinase A-Raf that is encoded in the genome of human.


PCSK6_HUMAN Proprotein convertase subtilisin/kexin type 6 (sprot)

A proprotein convertase subtilisin/kexin type 6 that is encoded in the genome of human.


FGD1_HUMAN FYVE, RhoGEF and PH domain-containing protein 1 (sprot)

A FYVE, RhoGEF and PH domain-containing protein 1 that is encoded in the genome of human.


SOS2_HUMAN Son of sevenless homolog 2 (sprot)

A son of sevenless homolog 2 that is encoded in the genome of human.


ARHG5_HUMAN Rho guanine nucleotide exchange factor 5 (sprot)

A Rho guanine nucleotide exchange factor 5 that is encoded in the genome of human.


AKP13_HUMAN A-kinase anchor protein 13 (sprot)

An A-kinase anchor protein 13 that is encoded in the genome of human.


ABR_HUMAN Active breakpoint cluster region-related protein (sprot)

An active breakpoint cluster region-related protein that is encoded in the genome of human.


FGD3_HUMAN FYVE, RhoGEF and PH domain-containing protein 3 (sprot)

A FYVE, RhoGEF and PH domain-containing protein 3 that is encoded in the genome of human.


OBSCN_HUMAN Obscurin (sprot)

An obscurin that is encoded in the genome of human.


ARHGG_HUMAN Rho guanine nucleotide exchange factor 16 (sprot)

A Rho guanine nucleotide exchange factor 16 that is encoded in the genome of human.


ARHGI_HUMAN Rho guanine nucleotide exchange factor 18 (sprot)

A Rho guanine nucleotide exchange factor 18 that is encoded in the genome of human.


ARHG8_HUMAN Neuroepithelial cell-transforming gene 1 protein (sprot)

A neuroepithelial cell-transforming gene 1 protein that is encoded in the genome of human.


FGD2_HUMAN FYVE, RhoGEF and PH domain-containing protein 2 (sprot)

A FYVE, RhoGEF and PH domain-containing protein 2 that is encoded in the genome of human.


ARHGJ_HUMAN Rho guanine nucleotide exchange factor 19 (sprot)

A Rho guanine nucleotide exchange factor 19 that is encoded in the genome of human.


ARG39_HUMAN Rho guanine nucleotide exchange factor 39 (sprot)

A Rho guanine nucleotide exchange factor 39 that is encoded in the genome of human.


PREX1_HUMAN Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (sprot)

A phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein that is encoded in the genome of human.


ARH40_HUMAN Rho guanine nucleotide exchange factor 40 (sprot)

A Rho guanine nucleotide exchange factor 40 that is encoded in the genome of human.


ARHG2_HUMAN Rho guanine nucleotide exchange factor 2 (sprot)

A Rho guanine nucleotide exchange factor 2 that is encoded in the genome of human.


ARHGQ_HUMAN Rho guanine nucleotide exchange factor 26 (sprot)

A Rho guanine nucleotide exchange factor 26 that is encoded in the genome of human.


FGD4_HUMAN FYVE, RhoGEF and PH domain-containing protein 4 (sprot)

A FYVE, RhoGEF and PH domain-containing protein 4 that is encoded in the genome of human.


ARHGH_HUMAN Rho guanine nucleotide exchange factor 17 (sprot)

A Rho guanine nucleotide exchange factor 17 that is encoded in the genome of human.


PI51A_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (sprot)

A phosphatidylinositol 4-phosphate 5-kinase type-1 alpha that is encoded in the genome of human.


PKHG2_HUMAN Pleckstrin homology domain-containing family G member 2 (sprot)

A pleckstrin homology domain-containing family G member 2 that is encoded in the genome of human.


ARGAL_HUMAN Rho guanine nucleotide exchange factor 10-like protein (sprot)

A Rho guanine nucleotide exchange factor 10-like protein that is encoded in the genome of human.


ARHG4_HUMAN Rho guanine nucleotide exchange factor 4 (sprot)

A Rho guanine nucleotide exchange factor 4 that is encoded in the genome of human.


ARHG3_HUMAN Rho guanine nucleotide exchange factor 3 (sprot)

A Rho guanine nucleotide exchange factor 3 that is encoded in the genome of human.


ARH38_HUMAN Rho guanine nucleotide exchange factor 38 (sprot)

A Rho guanine nucleotide exchange factor 38 that is encoded in the genome of human.


A dicarboxylic acid dianion that results from the deprotonation of both of the carboxylic acid groups of itaconic acid.


detection of bacterium

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.


pancreatic PP cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A PP cell located in the islets of the pancreas.


endothelial cell of hepatic sinusoid

An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates.


liver

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].


skin epidermis

The outer epithelial layer of the skin that is superficial to the dermis.


enucleate erythrocyte

An erythrocyte lacking a nucleus.


nasal cavity

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An anatomical cavity that is part of the olfactory apparatus. This includes the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present.


ascospore-type prospore

An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi.


retromer complex

A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35.


fatty acid synthase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.


6-phosphofructokinase activity

Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.


phosphopyruvate hydratase activity

Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.


fructose-bisphosphate aldolase activity

Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.


phosphoglycerate mutase activity

Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.


glucose-6-phosphate isomerase activity

Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.


phosphoglycerate kinase activity

Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+.


glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.


triose-phosphate isomerase activity

Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.


epoxide hydrolase activity

Catalysis of the reaction: an epoxide + H2O = a glycol.


tryptophan-tRNA ligase activity

Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).


non-canonical Wnt signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin.


protein-disulfide reductase activity

Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.


thioredoxin-disulfide reductase (NADP) activity

Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH.


RNA helicase activity

Unwinding of an RNA helix, driven by ATP hydrolysis.


GDP-L-fucose synthase activity

Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+.


GDP-mannose 4,6-dehydratase activity

Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H2O.


mannose-1-phosphate guanylyltransferase (GTP) activity

Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.


glutathione transferase activity

Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.


xanthine dehydrogenase activity

Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.


phosphomannomutase activity

Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.


hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.


tryptophan 5-monooxygenase activity

Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.


deaminase activity

Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R).


Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.


Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.


hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.


glucosylceramidase activity

Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.


lysophospholipase activity

Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.


6,7-dihydropteridine reductase activity

Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine.


molecular carrier activity

Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location.


L-glutamate transmembrane transporter activity

Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.


heme binding

Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.


nuclear estrogen receptor activity

Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.


microtubule motor activity

A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.


lipoteichoic acid binding

Binding to lipoteichoic acid.


Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine.


adenosine deaminase activity

Catalysis of the reaction: adenosine + H2O = inosine + NH3.


xanthine oxidase activity

Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide.


hypoxanthine oxidase activity

Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2.


5'-nucleotidase activity

Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.


hypoxanthine dehydrogenase activity

Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+.


Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.


guanine deaminase activity

Catalysis of the reaction: guanine + H2O = xanthine + NH3.


deoxyribonucleoside 5'-monophosphate N-glycosidase activity

Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base.


AMP deaminase activity

Catalysis of the reaction: AMP + H2O = IMP + NH3.


GMP 5'-nucleotidase activity

Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate.


2'-deoxyadenosine deaminase activity

Catalysis of the reaction: 2'-deoxyadenosine + H2O = deoxyinosine + NH3.


IMP 5'-nucleotidase activity

Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate.


deoxyuridine phosphorylase activity

Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate.


dihydropyrimidinase activity

Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.


dihydropyrimidine dehydrogenase (NADP+) activity

Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+.


beta-ureidopropionase activity

Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3.


uridine phosphorylase activity

Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.


thymidine phosphorylase activity

Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate.


glutathione disulfide oxidoreductase activity

Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.


superoxide dismutase activity

Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.


misfolded protein binding

Binding to a misfolded protein.


Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+.


3'-5'-RNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.


GMP synthase (glutamine-hydrolyzing) activity

Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+.


Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.


IMP dehydrogenase activity

Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.


adenosine kinase activity

Catalysis of the reaction: ATP + adenosine = ADP + AMP.


adenylosuccinate synthase activity

Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate.


Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.


GMP reductase activity

Catalysis of the reaction: IMP + NADP+ + NH4 = GMP + 2 H+ + NADPH.


deoxyadenosine kinase activity

Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+.


deoxyguanosine kinase activity

Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H+.


protein tyrosine/serine/threonine phosphatase activity

Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


creatine kinase activity

Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+.


(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity

Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.


Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate.


IMP cyclohydrolase activity

Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.


Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate.


Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.


amidophosphoribosyltransferase activity

Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O.


Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate.


Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.


Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate.


Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.


Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.


aspartate carbamoyltransferase activity

Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate.


dihydroorotase activity

Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+.


Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP.


carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.


JUN kinase kinase kinase kinase activity

Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs).


uridine kinase activity

Catalysis of the reaction: ATP + uridine = ADP + UMP.


nucleoside diphosphate kinase activity

Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.


ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor

Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin.


nucleoside triphosphate diphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate.


L-phosphoserine phosphatase activity

Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid.


Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.


[methionine synthase] reductase activity

Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+.


methionine synthase activity

Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.


cyanocobalamin reductase (cyanide-eliminating) activity

Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP+ = cyanocob(III)alamin + H+ + NADPH.


methyltransferase activity

Catalysis of the transfer of a methyl group to an acceptor molecule.


D-xylulose reductase activity

Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH.


azetidine-2-carboxylic acid acetyltransferase activity

Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid.


phosphatidate phosphatase activity

Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.


acetyl-CoA C-acetyltransferase activity

Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.


sulfinoalanine decarboxylase activity

Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2.


glutamate dehydrogenase (NAD+) activity

Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.


tRNA dimethylallyltransferase activity

Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine.


non-membrane spanning protein tyrosine phosphatase activity

Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.


fructose 1,6-bisphosphate 1-phosphatase activity

Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.


L-malate dehydrogenase activity

Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.


RNA nuclease activity

Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.


tubulin-glutamic acid ligase activity

Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.


Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+.


Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate.


Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO2 + H+ + isopentenyl diphosphate + phosphate.


phosphomevalonate kinase activity

Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H+.


sterol 24-C-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + zymosterol = fecosterol + H+ + S-adenosyl-L-homocysteine.


hydroxymethylglutaryl-CoA reductase (NADPH) activity

Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH.


mevalonate kinase activity

Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+.


iron ion binding

Binding to an iron (Fe) ion.


fructose-1-phosphate aldolase activity

Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde.


triokinase activity

Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H+.


ketohexokinase activity

Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate.


aldehyde dehydrogenase (NAD+) activity

Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.


glycerate kinase activity

Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+.


Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.


D-sorbitol dehydrogenase (acceptor) activity

Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor.


L-iditol 2-dehydrogenase activity

Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.


Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.


galactokinase activity

Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+.


UDP-glucose 4-epimerase activity

Catalysis of the reaction: UDP-glucose = UDP-galactose.


6-phosphogluconolactonase activity

Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+.


phosphogluconate dehydrogenase (decarboxylating) activity

Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.


ribose-5-phosphate isomerase activity

Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate.


transketolase activity

Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.


Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate.


transaldolase activity

Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.


bisphosphoglycerate mutase activity

Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.


ribokinase activity

Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate.


ribose phosphate diphosphokinase activity

Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+.


amylo-alpha-1,6-glucosidase activity

Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present.


phosphorylase kinase activity

Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.


4-alpha-glucanotransferase activity

Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.


xylulokinase activity

Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H+.


Catalysis of the reaction: 3-dehydro-L-gulonate + H+ = L-xylulose + CO2.


L-gulonate 3-dehydrogenase activity

Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH.


L-glucuronate reductase activity

Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH.


L-xylulose reductase (NADP+) activity

Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH.


small molecule sensor activity

Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule.


arginine binding

Binding to 2-amino-5-(carbamimidamido)pentanoic acid.


alcohol dehydrogenase (NADP+) activity

Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+.


6-methylsalicylic acid synthase activity

Catalysis of the reaction: acetyl-CoA + 3 H+ + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP+.


Catalysis of the reaction: 6-methylsalicylate + H+ = 3-cresol + CO2.


aldo-keto reductase (NADP) activity

Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.


sulfate adenylyltransferase (ATP) activity

Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate.


adenylylsulfate kinase activity

Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate.


alpha-mannosidase activity

Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.


ATP citrate synthase activity

Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA.


O-methyltransferase activity

Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.


enoyl-CoA hydratase activity

Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O.


polyketide synthase activity

Catalysis of a multistep reaction that produce polyketides through decarboxylative condensation of carboxylic acids. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization.


fatty acyl-CoA hydrolase activity

Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.


cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.


isopenicillin-N synthase activity

Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N.


Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H+.


carboxypeptidase activity

Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain.


cyclase activity

Catalysis of a ring closure reaction.


versicolorin B synthase activity

Catalysis of the reaction: versiconal = versicolorin B + H2O.


Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine.


Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH.


flavin reductase (NADH) activity

Catalysis of the reaction: a reduced flavin + NAD+ = an oxidized flavin + 2 H+ + NADH.


versicolorin reductase activity

Catalysis of the reduction of versicolorin A to sterigmatocystin.


acyltransferase activity

Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).


Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.


eukaryotic translation initiation factor 2alpha kinase activity

Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate.


metallocarboxypeptidase activity

Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


peroxisome matrix targeting signal-2 binding

Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F).


lactoylglutathione lyase activity

Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.


guanylate cyclase activity

Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.


Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine.


aconitate hydratase activity

Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.


malate dehydrogenase (decarboxylating) (NADP+) activity

Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.


isocitrate dehydrogenase (NADP+) activity

Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.


L-lactate dehydrogenase activity

Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.


N-acetylglucosamine kinase activity

Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H+.


kynureninase activity

Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine.


Catalysis of the reaction: 3-hydroxyanthranilate + O2 = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H+.


kynurenine 3-monooxygenase activity

Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+.


pyridoxamine phosphate oxidase activity

Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + hydrogen peroxide.


UDP-glucose 6-dehydrogenase activity

Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate.


K48-linked deubiquitinase activity

Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin.


6-phosphofructo-2-kinase activity

Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+.


retinal dehydrogenase activity

Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.


Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers.


protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.


Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.


aspartoacylase activity

Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate.


metalloaminopeptidase activity

Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


acetyl-CoA carboxylase activity

Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.


inositol hexakisphosphate kinase activity

Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.


glycerol kinase activity

Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+.


oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen.


guanyl nucleotide binding

Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate.


thiamine diphosphokinase activity

Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate.


thiamine triphosphate phosphatase activity

Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate.


thiamine-diphosphate kinase activity

Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate.


riboflavin kinase activity

Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+.


FMN adenylyltransferase activity

Catalysis of the reaction: ATP + FMN = diphosphate + FAD.


Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H+ = CO2 + pantetheine 4'-phosphate.


pantothenate kinase activity

Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.


Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives.


phosphotransferase activity, alcohol group as acceptor

Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).


pyridoxal kinase activity

Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.


pyridoxal phosphatase activity

Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.


pyridoxal oxidase activity

Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide.


biotin-protein ligase activity

Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein.


sulfurtransferase activity

Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).


Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.


molybdopterin synthase activity

Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.


cysteine desulfurase activity

Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine.


Mo-molybdopterin cofactor sulfurase activity

Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase.


glycerol-3-phosphate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+.


catechol O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.


cysteine-type endopeptidase activator activity involved in apoptotic process

Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.


Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate.


aldehyde-lyase activity

Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.


Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate.


porphobilinogen synthase activity

Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen.


coproporphyrinogen oxidase activity

Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX.


5-aminolevulinate synthase activity

Catalysis of the reaction: glycine + H+ + succinyl-CoA = 5-aminolevulinate + CO2 + CoA.


uroporphyrinogen-III synthase activity

Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III.


uroporphyrinogen decarboxylase activity

Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2.


hydroxymethylbilane synthase activity

Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4.


phospholipase activity

Catalysis of the hydrolysis of a glycerophospholipid.


fatty acid elongase activity

Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.


phospholipase A2 activity

Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.


carbonate dehydratase activity

Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O.


Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.


NADP-retinol dehydrogenase activity

Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.


cytoskeletal motor activity

Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).


sulfotransferase activity

Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.


aryl sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.


SNARE binding

Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.


Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.


glutamate-cysteine ligase activity

Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate.


cysteine dioxygenase activity

Catalysis of the reaction: L-cysteine + O2 = 3-sulfino-L-alanine + H+.


N-acylglucosamine 2-epimerase activity

Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine.


electron transfer activity

A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.


methylenetetrahydrofolate reductase (NAD(P)H) activity

Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.


peptide-methionine (S)-S-oxide reductase activity

Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.


carbonyl reductase (NADPH) activity

Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.


calcium-dependent cysteine-type endopeptidase activity

Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.


peroxidase activity

Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.


15-hydroxyprostaglandin dehydrogenase (NAD+) activity

Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+.


selenide, water dikinase activity

Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate.


calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.


arylamine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.


Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+.


spermine synthase activity

Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.


thioredoxin peroxidase activity

Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O.


Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine.


inositol bisphosphate phosphatase activity

Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate.


NAD-retinol dehydrogenase activity

Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.


Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+.


Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.


sphinganine kinase activity

Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate.


Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.


Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.


arginase activity

Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.


Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2.


tubulin deacetylase activity

Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate.


steroid hydroxylase activity

Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.


Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate.


glutamine-fructose-6-phosphate transaminase (isomerizing) activity

Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.


protein-arginine deiminase activity

Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent.


Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H+ = 5,10-methenyltetrahydrofolate + NH4.


Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine.


geranyltranstransferase activity

Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.


phospholipase A1 activity

Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.


maleylacetoacetate isomerase activity

Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate.


lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.


Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.


methionine-tRNA ligase activity

Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).


Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4.


very long-chain fatty acid-CoA ligase activity

Catalysis of the reaction: a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


fatty-acyl-CoA synthase activity

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.


alcohol dehydrogenase activity, zinc-dependent

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.


Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone.


asparagine synthase (glutamine-hydrolyzing) activity

Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.


serine racemase activity

Catalysis of the synthesis of free D-serine from L-serine.


peptide-methionine (R)-S-oxide reductase activity

Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.


adenyl-nucleotide exchange factor activity

Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.


carboxylic ester hydrolase activity

Catalysis of the hydrolysis of a carboxylic ester bond.


phosphoglycerate dehydrogenase activity

Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.


dipeptidase activity

Catalysis of the hydrolysis of a dipeptide.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.


glucosamine 6-phosphate N-acetyltransferase activity

Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+.


dimethylargininase activity

Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.


prostaglandin-D synthase activity

Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).


N-acylmannosamine kinase activity

Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate.


aldehyde dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.


acetate-CoA ligase activity

Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.


Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.


Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.


UDP-sugar diphosphatase activity

Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate.


ADP-ribose diphosphatase activity

Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.


asparaginase activity

Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.


pseudouridine synthase activity

Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.


nicotinate-nucleotide diphosphorylase (carboxylating) activity

Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate.


ferroxidase activity

Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.


glutamine-tRNA ligase activity

Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).


diamine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.


tubulin-tyrosine ligase activity

Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.


aminoacylase activity

Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid.


aldehyde oxidase activity

Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.


phosphatidylinositol transfer activity

Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


ADP-specific glucokinase activity

Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate.


phenylalanine 4-monooxygenase activity

Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.


Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine.


N-acetylneuraminate lyase activity

Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.


Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.


Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate.


dITP diphosphatase activity

Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate.


primary amine oxidase activity

Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.


Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.


NAD+ synthase (glutamine-hydrolyzing) activity

Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.


Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal.


guanylate kinase activity

Catalysis of the reaction: ATP + GMP = ADP + GDP.


acid phosphatase activity

Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.


Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide.


arsenite methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.


inositol monophosphate 1-phosphatase activity

Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate.


estradiol 17-beta-dehydrogenase [NAD(P)] activity

Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor.


racemase and epimerase activity, acting on carbohydrates and derivatives

Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule.


isoleucine-tRNA ligase activity

Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+.


carnosine synthase activity

Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine.


Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate.


Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor.


ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.


carboxy-lyase activity

Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.


oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.


microtubule severing ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.


ornithine decarboxylase activity

Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine.


arginine decarboxylase activity

Catalysis of the reaction: L-arginine + H+ = agmatine + CO2.


glycine-tRNA ligase activity

Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).


exo-alpha-sialidase activity

Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.


deoxyhypusine synthase activity

Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+.


Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate.


Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.


adenosylhomocysteinase activity

Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.


adenylate kinase activity

Catalysis of the reaction: ATP + AMP = 2 ADP.


biliverdin reductase (NAD(P)+) activity

Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+.


choline O-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.


Catalysis of the reaction: L-amino acid + H+ = R-H + CO2.


fumarylacetoacetase activity

Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+.


GTP cyclohydrolase I activity

Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+.


Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.


glutathione-disulfide reductase (NADP) activity

Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.


glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate.


histidine ammonia-lyase activity

Catalysis of the reaction: L-histidine = urocanate + NH3.


histidine decarboxylase activity

Catalysis of the reaction: L-histidine = histamine + CO2.


Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.


tryptophan 2,3-dioxygenase activity

Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.


mannose-6-phosphate isomerase activity

Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.


Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.


transaminase activity

Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.


tyrosine 3-monooxygenase activity

Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O.


thiopurine S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.


isomerase activity

Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.


Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.


acireductone dioxygenase [iron(II)-requiring] activity

Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+.


Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.


methylthioribulose 1-phosphate dehydratase activity

Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O.


spermidine synthase activity

Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine.


Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.


acireductone synthase activity

Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.


sterol transporter activity

Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


spermine:oxygen oxidoreductase (spermidine-forming) activity

Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine.


N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity

Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine.


cGMP-dependent protein kinase activity

cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


sepiapterin reductase activity

Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+.


phosphatidylinositol phosphate 4-phosphatase activity

Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate.


Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.


phosphocholine phosphatase activity

Catalysis of the reaction: choline phosphate + H2O = choline + phosphate.


pyridine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine.


methylarsonate reductase activity

Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid.


thiol S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether.


Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).


steroid sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.


estrone sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.


alcohol sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.


S-formylglutathione hydrolase activity

Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+.


peptidyltransferase activity

Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme.


Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide.


L-cysteine desulfhydrase activity

Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+.


carbon-sulfur lyase activity

Catalysis of the elimination of hydrogen sulfide or substituted H2S.


hypotaurine dehydrogenase activity

Catalysis of the reaction: H+ + hypotaurine + NADPH + O2 = H2O + NADP+ + taurine.


cysteamine dioxygenase activity

Catalysis of the reaction: cysteamine + O2 = H+ + hypotaurine.


homocysteine desulfhydrase activity

Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate.


Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+.


Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.


Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+.


Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H+.


ceramide 1-phosphate transfer activity

Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


glycolipid transfer activity

Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid.


gamma-glutamylcyclotransferase activity

Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.


inositol pentakisphosphate 2-kinase activity

Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H+.


Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+.


inositol diphosphate pentakisphosphate diphosphatase activity

Catalysis of the reaction: diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate.


inositol tetrakisphosphate 1-kinase activity

Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.


inositol diphosphate tetrakisphosphate diphosphatase activity

Catalysis of the reaction: diphospho-1D-myo-inositol tetrakisphosphate + H2O = 1D-myo-inositol pentakisphosphate + phosphate.


inositol heptakisphosphate kinase activity

Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown.


Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown.


inositol diphosphate tetrakisphosphate kinase activity

Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate.


inositol 5-diphosphate pentakisphosphate 5-kinase activity

Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate.


Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H+.


Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H+.


inositol bisdiphosphate tetrakisphosphate diphosphatase activity

Catalysis of the reaction: bisdiphospho-1D-myo-inositol tetrakisphosphate + H2O = diphospho-1D-myo-inositol pentakisphosphate + phosphate.


Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate.


Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.


Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate.


Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate.


Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.


inositol monophosphate 3-phosphatase activity

Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate.


Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate.


inositol oxygenase activity

Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O + H+.


inositol-3-phosphate synthase activity

Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.


Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate.


Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.


inositol monophosphate 4-phosphatase activity

Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate.


Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate.


RNA methyltransferase activity

Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.


dimethylallyltranstransferase activity

Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.


glutathione dehydrogenase (ascorbate) activity

Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.


ribosylnicotinamide kinase activity

Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide.


ribosylnicotinate kinase activity

Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide.


NAD+ kinase activity

Catalysis of the reaction: ATP + NAD+ = ADP + 2 H+ + NADP+.


Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate.


Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.


methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.


folate reductase activity

Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+.


Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate.


Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.


nitric oxide dioxygenase NAD(P)H activity

Catalysis of the reaction: 2 NO + 2 O2 + NAD(P)H + H+ = 2 nitrate + NAD(P)+.


ribonuclease III activity

Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.


deoxyhypusine monooxygenase activity

Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O.


Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.


S-methyltransferase activity

Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule.


Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine.


glutamine synthetase activity

Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate.


dihydronicotinamide riboside quinone reductase activity

Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.


hepoxilin-epoxide hydrolase activity

Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate.


hepoxilin A3 synthase activity

Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.


Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate.


arachidonate 15-lipoxygenase activity

Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.


13-lipoxin reductase activity

Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+.


N6-methyl-AMP deaminase activity

Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate.


nucleoside phosphotransferase activity

Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate.


nucleoside monophosphate kinase activity

Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate.


prostaglandin H2 endoperoxidase reductase activity

Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).


13-prostaglandin reductase activity

Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin.


prostaglandin-E2 9-reductase activity

Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.


prostaglandin D2 11-ketoreductase activity

Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+.


prostaglandin-E synthase activity

Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2).


selenodiglutathione-disulfide reductase (NADP) activity

Catalysis of the reaction: H+ + selenodiglutathione + NADPH = gluthathioselenol + glutathione + NADP+.


8-oxo-dGDP phosphatase activity

Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate.


2-hydroxy-dATP hydrolase activity

Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate.


8-hydroxy-dADP phosphatase activity

Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate.


8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.


8-oxo-GDP phosphatase activity

Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate.


8-oxo-(d)RTP hydrolase activity

Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+.


2-hydroxy-ATP hydrolase activity

Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate.


selenomethionine-tRNA ligase activity

Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met).


selenite reductase activity

Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O.


adenylylselenate kinase activity

Catalysis of the reaction: ATP + adenylylselenate => ADP + 3'-phosphoadenylylselenate.


Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+.


selenate adenylyltransferase (ATP) activity

Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate.


adenosylselenohomocysteinase activity

Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine.


methylselenol reductase activity

Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O.


selenol Se-methyltransferase activity

Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine.


Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O.


Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine.


selenomethionine gamma-lyase activity

Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid.


Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid.


Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol.


hydrogen selenide methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol.


selenocysteine lyase activity

Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor.


methylselenol demethylase activity

Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH.


Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide.


dimethyl selenide methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium.


O-phosphoseryl-tRNA(Sec) selenium transferase activity

Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid.


Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP.


selenocysteine-tRNA ligase activity

Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate.


glycine N-acyltransferase activity

Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine.


iron-sulfur transferase activity

Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor).


histone H3 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue.


inorganic diphosphate phosphatase activity

Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate.


glutamate-tRNA ligase activity

Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).


valine-tRNA ligase activity

Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H+.


alanine-tRNA ligase activity

Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).


phenylalanine-tRNA ligase activity

Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).


histidine-tRNA ligase activity

Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).


leucine-tRNA ligase activity

Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu).


lysine-tRNA ligase activity

Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).


threonine-tRNA ligase activity

Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).


cysteine-tRNA ligase activity

Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).


asparagine-tRNA ligase activity

Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H+.


proline-tRNA ligase activity

Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).


arginine-tRNA ligase activity

Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).


Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate.


argininosuccinate synthase activity

Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.


glycine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.


myosin phosphatase activity

Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.


Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine.


beta-adrenergic receptor kinase activity

Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor.


RNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.


RNA exonuclease activity, producing 5'-phosphomonoesters

Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.


myosin light chain kinase activity

Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.


Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.


Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.


nucleoside kinase activity

Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.


CTP synthase activity

Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.


dCMP deaminase activity

Catalysis of the reaction: dCMP + H2O = dUMP + NH3.


dCTP diphosphatase activity

Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate.


methylseleninic acid reductase activity

Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O.


diphthine-ammonia ligase activity

Catalysis of the reaction: ATP + diphthine + NH4 = ADP + diphthamide + H+ + phosphate.


protein methylesterase activity

Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol.


Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2].


diphthine synthase activity

Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H+ + 3 S-adenosyl-L-homocysteine.


Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.


Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+.


tRNA dihydrouridine synthase activity

Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H.


nucleotidyltransferase activity

Catalysis of the transfer of a nucleotidyl group to a reactant.


Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil.


fucokinase activity

Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+.


Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP + H+ = diphosphate + GDP-beta-L-fucose.


Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.


Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H+.


glycerol-3-phosphatase activity

Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate.


argininosuccinate lyase activity

Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.


urocanate hydratase activity

Catalysis of the reaction: 4-imidazolone-5-propanoate + H+ = trans-urocanate + H2O.


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide.


histamine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H+.


carnosine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H+.


Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.


Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate.


arylformamidase activity

Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine.


deoxyribose-phosphate aldolase activity

Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.


sedoheptulokinase activity

Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H+ + sedoheptulose 7-phosphate.


phosphopentomutase activity

Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate.


Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine.


pentosyltransferase activity

Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor).


myristoyltransferase activity

Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule.


ITP diphosphatase activity

Catalysis of the reaction: ITP + H2O = IMP + H+ + diphosphate.


XTP diphosphatase activity

Catalysis of the reaction: XTP + H2O = XMP + H+ + diphosphate.


fatty acyl-[ACP] hydrolase activity

Catalysis of the reaction: a fatty acyl-[ACP] + H2O = a fatty acid + H(+) + holo-[acyl-carrier protein].


palmitoyl hydrolase activity

Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate.


Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH.


Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.


acetoacetate-CoA ligase activity

Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+.


hydro-lyase activity

Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.


glutamate decarboxylase activity

Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.


protein-glycine ligase activity

Catalysis of the reaction: ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H+ + phosphate.


Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.


homogentisate 1,2-dioxygenase activity

Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+.


Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.


beta-aspartyl-peptidase activity

Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide.


Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine.


Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine.


Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.


oligoribonucleotidase activity

Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates.


phospholipid-hydroperoxide glutathione peroxidase activity

Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.


NADPH dehydrogenase activity

Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor.


D-serine ammonia-lyase activity

Catalysis of the reaction: D-serine = pyruvate + NH3.


Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.


threonine-type endopeptidase activity

Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.


sulfiredoxin activity

Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.


Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate.


succinate-semialdehyde dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+.