GTP-dependent protein binding

Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state.


protein localization to ciliary membrane

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A process in which a protein is transported to, or maintained in, a location within a ciliary membrane.


protein transmembrane transport

The process in which a protein is transported across a membrane.


EXOC4_HUMAN Exocyst complex component 4 (sprot)

An exocyst complex component 4 that is encoded in the genome of human.


AR13B_HUMAN ADP-ribosylation factor-like protein 13B (sprot)

An ADP-ribosylation factor-like protein 13B that is encoded in the genome of human.


phosphatidylinositol binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.


intraciliary transport particle A

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa.


TBC31_HUMAN TBC1 domain family member 31 (sprot)

A TBC1 domain family member 31 that is encoded in the genome of human.


aspartyl-tRNA aminoacylation

The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA.


myenteric nerve plexus

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

One of two ganglionated neural networks which together form the enteric nervous system. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility.


olfactory pit

An indentation of the olfactory placode which ends when the pits hollows out to form the nasopharynx[GO].


facial nerve

Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches).


vagus X ganglion

The group of sensory neuron cell bodies associated with the vagus nerve.


nerve innervating pinna

Any nerve that innervates the pinna.


spinal nerve

The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified].


ganglion

A biological tissue mass, most commonly a mass of nerve cell bodies.


substantia gelatinosa

Gelatinous-appearing material in the dorsal horn of the spinal cord, consisting chiefly of Golgi type II neurons and some larger nerve cells, corresponding to Rexed lamina II.


cervical ganglion

The cervical ganglia are paravertebral ganglia of the sympathetic nervous system. They consist of three paravertebral ganglia: superior cervical ganglion middle cervical ganglion inferior cervical ganglion. The inferior ganglion may be fused with the first thoracic ganglion to form a single structure, the stellate ganglion. Nerves emerging from cervical sympathetic ganglia contribute to the cardiac plexus, among other things. [WP,unvetted].


celiac ganglion

The celiac ganglia are two large irregularly shaped masses of nerve tissue in the upper abdomen. Part of the sympathetic subdivision of the autonomic nervous system (ANS), the two celiac ganglia are the largest ganglia in the ANS, and they innervate most of the digestive tract. They have the appearance of lymph glands and are placed on either side of the midline in front of the crura of the diaphragm, close to the suprarenal glands (also called adrenal glands). The ganglion on the right side is placed behind the inferior vena cava. They are sometimes referred to as the semilunar ganglia or the solar ganglia. [WP,unvetted].


superior cervical ganglion

Trunk ganglion which is bilaterally paired and located at the anterior end of the sympathetic ganglion chain.


vagus X nerve trunk

A nerve trunk that is part of a vagus nerve.


cochlear ganglion

The group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)[MP]. distributed to the hair cells of the spiral organ. The cochlear fibers arise in bipolar cells in the spiral ganglion in the modiolus.


nasal septum

The nasal septum separates the left and right airways in the nose, dividing the two nostrils. It is depressed by the Depressor septi nasi muscle. [WP,unvetted].


sensory ganglion

The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells.


hypoglossal nucleus

Nucleus forming a longitudinal cell column in the medulla, close beneath the floor of the 4th ventricle, containing motor neurons that innervate the muscles of the tongue (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 453).


nuclear periphery

The portion of the nuclear lumen proximal to the inner nuclear membrane.


C-fiber

The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated.


nBAF complex

A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.


cell body fiber

A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.


axon extension involved in regeneration

Long distance growth of a single axon process involved in regeneration of the neuron.


inhibitory chemical synaptic transmission

Synaptic transmission that results in an inhibitory postsynaptic potential.


synapse maturation

The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.


monoatomic cation transport

The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom.


protein aggregate center assembly

The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.


dendrite arborization

The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches.


action potential initiation

The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate.


glutamate metabolic process

The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.


lysosomal lumen acidification

Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.


mitotic nuclear division

A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.


aspartate N-acetyltransferase activity

Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H+.


norepinephrine secretion

The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system.


regulation of respiratory gaseous exchange

Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.


axon ensheathment

Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.


peripheral nervous system axon regeneration

The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury.


high voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.


neuron projection regeneration

The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage.


regulation of chloride transport

Any process that modulates the frequency, rate or extent of chloride transport.


regulation of peptidyl-tyrosine phosphorylation

Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS).


Notch receptor processing

The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor.


positive regulation of non-motile cilium assembly

Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly.


late endosome to lysosome transport

The directed movement of substances from late endosome to lysosome.


amyloid-beta binding

Binding to an amyloid-beta peptide/protein.


negative regulation of dendritic spine development

Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


activation of transmembrane receptor protein tyrosine kinase activity

Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity.


negative regulation of amyloid-beta formation

Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation.


mitochondrial calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.


neurotransmitter uptake

The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.


enterobactin transmembrane transporter activity

Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other.


LBD domain binding

Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket.


positive regulation of amyloid precursor protein catabolic process

Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process.


negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.


evoked excitatory postsynaptic potential

A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell induced by the evoked release of many vesicles of excitatory neurotransmitter at the synapse.


intermediate filament bundle assembly

The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs.


Schwann cell proliferation

The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.


cell morphogenesis involved in neuron differentiation

The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.


hypothalamus cell migration

The directed movement of a cell into the hypothalamus region of the forebrain.


cell adhesion molecule 1 isoform 4 (mouse)

A cell adhesion molecule 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R5M8-4.


cell adhesion molecule 1 isoform 2 (mouse)

A cell adhesion molecule 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R5M8-2.


cell adhesion molecule 1 isoform 3 (mouse)

A cell adhesion molecule 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R5M8-3.


neuregulin-1 type III (mouse)

A pro-neuregulin-1, membrane-bound isoform (mouse) that has an N-terminal cysteine-rich domain (CRD).


SYDC_HUMAN Aspartate--tRNA ligase, cytoplasmic (sprot)

An aspartate--tRNA ligase, cytoplasmic that is encoded in the genome of human.


forebrain

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The most anterior region of the brain including both the telencephalon and diencephalon.


photoreceptor ribbon synapse

A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.


olfactory bulb external plexiform layer

Cytoarchitectural part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer. The EPL is mostly neuropil composed almost entirely of mitral and tulfted cell dendrites and granule cell dendrites and their synaptic inputs.


olfactory bulb mitral cell layer

The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer.


Schaffer collateral - CA1 synapse

A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.


neocortex

An area of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN).


dorsal plus ventral thalamus

Subcortical brain region consisting of paired gray matter bodies in the dorsal diencephalon and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups.(MeSH). The dorsal topographic division of the interbrain. The macrodissected adult human thalamus was clearly illustrated by Vesalius in 1543 and the term as defined here was introduced by His in 1893. It includes the traditional epithalamus, dorsal thalamus, and ventral thalamus of Herrick (1910, pp. 494, 498). Also see Kuhlenbeck (1927, Ch. 9) and Jones (1985, p. 87).


spinal cord

Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).


cochlear hair cell ribbon synapse

A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density.


brainstem

Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized].


cerebral hemisphere

One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA].


regulation of cytoplasmic translational fidelity

Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code.


Ser-tRNA(Ala) hydrolase activity

Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala).


cerebellar Purkinje cell layer development

The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


alanyl-tRNA aminoacylation

The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.


tryptophanyl-tRNA aminoacylation

The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


SYWM_HUMAN Tryptophan--tRNA ligase, mitochondrial (sprot)

A tryptophan--tRNA ligase, mitochondrial that is encoded in the genome of human.


purinergic nucleotide receptor activity

Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


positive regulation of action potential

Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.


large intestinal transit

Migration of ingested material along the length of the large intestine.


maintenance of gastrointestinal epithelium

Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.


tryptaminium

An  ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3.


N-arachidonoylglycine

Biologically active derivative of anandamide


HCAR2_HUMAN Hydroxycarboxylic acid receptor 2 (sprot)

A hydroxycarboxylic acid receptor 2 that is encoded in the genome of human.


GPR18_HUMAN N-arachidonyl glycine receptor (sprot)

An N-arachidonyl glycine receptor that is encoded in the genome of human.


OXGR1_HUMAN 2-oxoglutarate receptor 1 (sprot)

A 2-oxoglutarate receptor 1 that is encoded in the genome of human.


CML1_HUMAN Chemerin-like receptor 1 (sprot)

A chemokine receptor-like protein CMKLR1 that is encoded in the genome of human.


GP183_HUMAN G-protein coupled receptor 183 (sprot)

A G-protein coupled receptor 183 that is encoded in the genome of human.


3-hydroxybutyric acid

A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.


CNR1_HUMAN Cannabinoid receptor 1 (sprot)

A cannabinoid receptor 1 that is encoded in the genome of human.


CNR2_HUMAN Cannabinoid receptor 2 (sprot)

A cannabinoid receptor 2 that is encoded in the genome of human.


MTR1A_HUMAN Melatonin receptor type 1A (sprot)

A melatonin receptor type 1A that is encoded in the genome of human.


MTR1B_HUMAN Melatonin receptor type 1B (sprot)

A melatonin receptor type 1B that is encoded in the genome of human.


GPR55_HUMAN G-protein coupled receptor 55 (sprot)

A G-protein coupled receptor 55 that is encoded in the genome of human.


negative regulation of lipid catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.


MKS complex

A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.


cardiac septum morphogenesis

The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.


embryonic digit morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.


regulation of smoothened signaling pathway

Any process that modulates the frequency, rate or extent of smoothened signaling.


common bile duct development

The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine.


determination of left/right asymmetry in nervous system

The establishment of the nervous system with respect to the left and right halves.


interventricular septum

Cardiac septum which separates the right ventricle from the left ventricle.[FMA].


apelin receptor activity

Combining with the peptide apelin to initiate a change in cell activity.


apelin receptor binding

Binding to an apelin receptor.


mechanoreceptor activity

Combining with a mechanical force and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.


dorsal root ganglion development

The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.


neural tube patterning

The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.


chondrocyte differentiation involved in endochondral bone morphogenesis

The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.


spinal cord motor neuron cell fate specification

The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.


ventral spinal cord interneuron specification

The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.


regulation of cerebellar granule cell precursor proliferation

The process that modulates the frequency, rate or extent of granule cell precursor proliferation.


spinal cord dorsal/ventral patterning

The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord.


frontonasal prominence

The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout.


pro-T cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.


extrinsic component of plasma membrane

The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


TOLIP_HUMAN Toll-interacting protein (sprot)

A Toll-interacting protein that is encoded in the genome of human.


HTF4_HUMAN Transcription factor 12 (sprot)

A transcription factor 12 that is encoded in the genome of human.


NLRX1_HUMAN NLR family member X1 (sprot)

An NLR family member X1 that is encoded in the genome of human.


MYF5_HUMAN Myogenic factor 5 (sprot)

A myogenic factor 5 that is encoded in the genome of human.


MYOD1_HUMAN Myoblast determination protein 1 (sprot)

A myoblast determination protein 1 that is encoded in the genome of human.


MYOG_HUMAN Myogenin (sprot)

A myogenin that is encoded in the genome of human.


ITF2_HUMAN Transcription factor 4 (sprot)

A transcription factor 4 that is encoded in the genome of human.


MYF6_HUMAN Myogenic factor 6 (sprot)

A myogenic factor 6 that is encoded in the genome of human.


A tripeptide comprising L-alanyl, gamma-D-glutamyl and meso-diaminopimelic acid residues in a linear sequence. It is a breakdown product of bacterial peptidoglycan and a NOD1 agonist.


extrinsic component of cytoplasmic side of plasma membrane

The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.


interleukin-1 receptor accessory protein isoform 1 (human)

An interleukin-1 receptor accessory protein isoform 1 that is encoded in the genome of human.


secretion of lacrimal gland

Aqueous substance secreted by the lacrimal gland.


milk

An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation.


seminal vesicle glandular cell

Glandular cell of seminal vesicle epithelium.


prostate gland secretion

A bodily secretion that is produced by the prostate gland.


chitinase activity

Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins.


beta-fructofuranosidase activity

Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside.


protease binding

Binding to a protease or a peptidase.


retinoid binding

Binding to a retinoid, a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.


Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine.


Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid.


sucrose alpha-glucosidase activity

Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose.


alpha-amylase activity

Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.


patulin

A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.


FKBPL_HUMAN FK506-binding protein-like (sprot)

An FK506-binding protein-like that is encoded in the genome of human.


vascular endothelial growth factor A, long form isoform 4 (mouse)

A vascular endothelial growth factor A, long form (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00731-4.


O54739_MOUSE NAD(P)(+)--arginine ADP-ribosyltransferase (trembl)

An ecto-ADP-ribosyltransferase 5 isoform 6 that is encoded in the genome of mouse.


cochlin p18 (mouse)

A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815), and includes at least one glycosylated residue. UniProtKB:Q62507, 26-134, MOD:00693.


cochlin p8 (mouse)

A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815) by aggrecanases proteolytic activity. This form results from the deglycosylation of the N-terminal fragment p18. UniProtKB:Q62507, 26-134.


C-C motif chemokine 27 isoform 1, signal peptide removed form (mouse)

A C-C motif chemokine 27 isoform 1 (mouse) that has had the signal peptide removed. UniProtKB:Q9Z1X0-1, 26-120.


C-C motif chemokine 27 isoform 1 (mouse)

A C-C motif chemokine 27 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z1X0-1.


carcinoembryonic antigen-related cell adhesion molecule 10, cleaved and N-glycosylated (mouse)

A carcinoembryonic antigen-related cell adhesion molecule 10, signal peptide removed form that has been post-translationally cleaved on the peptide bond between Thr-33 and Ala-34, or between Ala-34 and Gln-35, or Glu-39 and Ala-40 and glycosylated on the Asn residue within the glycosylation consensus sequence NVT in mouse.


advanced glycosylation end product-specific receptor isoform 2 (mouse)

An advanced glycosylation end product-specific receptor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q62151-2.


secreted RAGE (mouse)

An advanced glycosylation end product-specific receptor (mouse) that consists of the ectodomain region of the protein which can be a product of a splice form or a proteolytic cleavage.


neuregulin-1 type I-beta1a mature form (mouse)

A neuregulin-1 type I-beta1a (mouse) that has been proteolytically processed by the Meltrin beta/ADAM19 metalloprotease to produce a soluble form consisting of the ectodomain.


PLA1A_HUMAN Phospholipase A1 member A (sprot)

A phospholipase A1 member A that is encoded in the genome of human.


PHLD_HUMAN Phosphatidylinositol-glycan-specific phospholipase D (sprot)

A phosphatidylinositol-glycan-specific phospholipase D that is encoded in the genome of human.


CHIT1_HUMAN Chitotriosidase-1 (sprot)

A chitotriosidase-1 that is encoded in the genome of human.


CHIA_HUMAN Acidic mammalian chitinase (sprot)

An acidic mammalian chitinase that is encoded in the genome of human.


CEMIP_HUMAN Cell migration-inducing and hyaluronan-binding protein (sprot)

A cell migration-inducing and hyaluronan-binding protein that is encoded in the genome of human.


NEUL_HUMAN Neurolysin, mitochondrial (sprot)

A neurolysin, mitochondrial that is encoded in the genome of human.


NOTUM_HUMAN Palmitoleoyl-protein carboxylesterase NOTUM (sprot)

A protein notum that is encoded in the genome of human.


PCSK5_HUMAN Proprotein convertase subtilisin/kexin type 5 (sprot)

A proprotein convertase subtilisin/kexin type 5 that is encoded in the genome of human.


P20D1_HUMAN N-fatty-acyl-amino acid synthase/hydrolase PM20D1 (sprot)

An N-fatty-acyl-amino acid synthase/hydrolase PM20D1 that is encoded in the genome of human.


ATS4_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 4 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 4 that is encoded in the genome of human.


GPX5_HUMAN Epididymal secretory glutathione peroxidase (sprot)

An epididymal secretory glutathione peroxidase that is encoded in the genome of human.


LIPF_HUMAN Gastric triacylglycerol lipase (sprot)

A gastric triacylglycerol lipase that is encoded in the genome of human.


CBPB1_HUMAN Carboxypeptidase B (sprot)

A carboxypeptidase B that is encoded in the genome of human.


CBPA3_HUMAN Mast cell carboxypeptidase A (sprot)

A mast cell carboxypeptidase A that is encoded in the genome of human.


LIPP_HUMAN Pancreatic triacylglycerol lipase (sprot)

A pancreatic triacylglycerol lipase that is encoded in the genome of human.


KLK7_HUMAN Kallikrein-7 (sprot)

A kallikrein-7 that is encoded in the genome of human.


LIPR1_HUMAN Inactive pancreatic lipase-related protein 1 (sprot)

A pancreatic lipase-related protein 1 that is encoded in the genome of human.


LIPR2_HUMAN Pancreatic lipase-related protein 2 (sprot)

A pancreatic lipase-related protein 2 that is encoded in the genome of human.


GPX6_HUMAN Glutathione peroxidase 6 (sprot)

A glutathione peroxidase 6 that is encoded in the genome of human.


PAPP1_HUMAN Pappalysin-1 (sprot)

A pappalysin-1 that is encoded in the genome of human.


LIPR3_HUMAN Pancreatic lipase-related protein 3 (sprot)

A pancreatic lipase-related protein 3 that is encoded in the genome of human.


LIPN_HUMAN Lipase member N (sprot)

A lipase member N that is encoded in the genome of human.


LIPK_HUMAN Lipase member K (sprot)

A lipase member K that is encoded in the genome of human.


LIPM_HUMAN Lipase member M (sprot)

A lipase member M that is encoded in the genome of human.


LIPJ_HUMAN Lipase member J (sprot)

A lipase member J that is encoded in the genome of human.


ATS16_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 16 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 16 that is encoded in the genome of human.


ATS18_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 18 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 18 that is encoded in the genome of human.


CBPB2_HUMAN Carboxypeptidase B2 (sprot)

A carboxypeptidase B2 that is encoded in the genome of human.


PAPP2_HUMAN Pappalysin-2 (sprot)

A pappalysin-2 that is encoded in the genome of human.


ATS9_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 9 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 9 that is encoded in the genome of human.


ATS1_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 1 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 1 that is encoded in the genome of human.


ATS5_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 5 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 5 that is encoded in the genome of human.


ATS8_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 8 (sprot)

An a disintegrin and metalloproteinase with thrombospondin motifs 8 that is encoded in the genome of human.


positive regulation of inflammatory response

Any process that activates or increases the frequency, rate or extent of the inflammatory response.


CARD8 inflammasome complex assembly

The aggregation, arrangement and bonding together of a set of components to form a CARD8 inflammasome complex.


positive regulation of interleukin-18 production

Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.


POL_HV1H2 Gag-Pol polyprotein (sprot)

A lentivirus-type gag-pol polyprotein that is encoded in the genome of human immunodeficiency virus type 1 group M subtype B (isolate HXB2).


type III interferon-mediated signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by type III interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far.


NAD-dependent protein demyristoylase activity

Catalysis of the reaction: N6-tetradecanoyl-L-lysyl-[protein] + NAD+ + H2O = tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.


RNA 7-methylguanosine cap binding

Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.


interleukin-6 receptor subunit alpha isoform 1 (human)

An interleukin-6 receptor subunit alpha isoform 2 that is encoded in the genome of human.


GGYF2_HUMAN GRB10-interacting GYF protein 2 (sprot)

A GRB10-interacting GYF protein 2 that is encoded in the genome of human.


IF4E2_HUMAN Eukaryotic translation initiation factor 4E type 2 (sprot)

A eukaryotic translation initiation factor 4E type 2 that is encoded in the genome of human.


CASP5_HUMAN Caspase-5 (sprot)

A caspase-5 that is encoded in the genome of human.


positive regulation of metaphase/anaphase transition of meiosis I

Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis I.


symbiont-mediated suppression of host translation initiation

A process in which a symbiont inhibits or disrupts translation initiation in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.


suppression by virus of host type I interferon production

Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


ribophagy

The selective degradation of mature ribosomes by macroautophagy.


HOPS complex

A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion.


protein-containing complex localization to centriolar satellite

A protein-containing complex localization by which the complex is transported to, or maintained in, the centriolar satellite.


ergosterol biosynthetic process

The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.


negative regulation of DNA repair

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.


negative regulation of translational initiation

Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.


symbiont-mediated suppression of host innate immune response

A process in which a symbiont inhibits or disrupts the normal execution of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction.


positive regulation of receptor signaling pathway via JAK-STAT

Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.


symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity

A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2).


postsynaptic neurotransmitter receptor cycle

The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane.


mitotic spindle assembly

Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.


protein localization involved in acrosome reaction

The actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction.


peptide antigen assembly with MHC class I protein complex

The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules.


positive regulation of cold-induced thermogenesis

Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.


symbiont-mediated perturbation of host NF-kappaB cascade

A process in which a symbiont alters or subverts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


negative regulation of type I interferon-mediated signaling pathway

Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway.


PML body organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).


Toll-like receptor 1-Toll-like receptor 2 protein complex

A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2).


TLR1_HUMAN Toll-like receptor 1 (sprot)

A Toll-like receptor 1 that is encoded in the genome of human.


RIG-I binding

Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.


protein kinase regulator activity

Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.


autophagosome-lysosome fusion

The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome.


sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity

Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one.


host cell nucleus

A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.


postsynaptic recycling endosome

A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation.


host cell endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).


host cell Golgi membrane

The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus.


TREM1_HUMAN Triggering receptor expressed on myeloid cells 1 (sprot)

A triggering receptor expressed on myeloid cells 1 that is encoded in the genome of human.


cytosolic small ribosomal subunit

The small subunit of a ribosome located in the cytosol.


GRIA1_HUMAN Glutamate receptor 1 (sprot)

A glutamate receptor 1 that is encoded in the genome of human.


OFD1_HUMAN Centriole and centriolar satellite protein OFD1 (sprot)

A centriole and centriolar satellite protein OFD1 that is encoded in the genome of human.


TAP1_HUMAN Antigen peptide transporter 1 (sprot)

An antigen peptide transporter 1 that is encoded in the genome of human.


KIF11_HUMAN Kinesin-like protein KIF11 (sprot)

A kinesin-like protein KIF11 that is encoded in the genome of human.


biolink:MacromolecularComplex biolink:BiologicalEntity biolink:NamedThing biolink:MacromolecularMachineMixin biolink:ThingWithTaxon


TPX2_HUMAN Targeting protein for Xklp2 (sprot)

A targeting protein for Xklp2 that is encoded in the genome of human.


TREM2_HUMAN Triggering receptor expressed on myeloid cells 2 (sprot)

A triggering receptor expressed on myeloid cells 2 that is encoded in the genome of human.


ZN598_HUMAN E3 ubiquitin-protein ligase ZNF598 (sprot)

An E3 ubiquitin-protein ligase ZNF598 that is encoded in the genome of human.


EBNA1_EBVB9 Epstein-Barr nuclear antigen 1 (sprot)

A protein that is a translation product of the EBNA1 gene in Human herpesvirus 4 strain B95-8.


RN170_HUMAN E3 ubiquitin-protein ligase RNF170 (sprot)

An E3 ubiquitin-protein ligase RNF170 that is encoded in the genome of human.


UHRF1_HUMAN E3 ubiquitin-protein ligase UHRF1 (sprot)

An E3 ubiquitin-protein ligase UHRF1 that is encoded in the genome of human.


symbiont-mediated disruption of host cell PML body

The process in which an organism effects a change that impairs the structure or function of the host PML body. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction.


negative regulation of kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


psicosamine

A hexosamine that is D-psicose in which the hydroxy group at position 1 is replaced by an amino group (substituted or unsubstituted).


ribulosamine

A pentosamine that is D-ribulose in which the hydroxy group at position 1 is replaced by an amino group (substituted or unsubstituted).


fructosamine 3-phosphate

A hexosamine phosphate that is fructosamine carrying a monophosphate group at position 3. The deglycation product of fructosamine


psicosamine 3-phosphate

A hexosamine phosphate that is any fructosamine carrying a monophosphate group at position 3. The deglycation product of psicosamine.


ribulosamine 3-phosphate

An amino sugar phosphate that is any ribulosamine carrying a monophosphate group at position 3. The deglycation product of ribulosamine


non-canonical inflammasome complex assembly

The aggregation, arrangement and bonding together of a set of components to form a non-canonical inflammasome complex.


positive regulation of pyroptosis

Any process that increases the frequency, rate or extent of pyroptosis.


symbiont-induced defense-related programmed cell death

Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules.


zinc chaperone activity

Binding to and delivering zinc ions to a target protein.


protein autoprocessing

Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.


MAP11_HUMAN Methionine aminopeptidase 1 (sprot)

A methionine aminopeptidase 1 that is encoded in the genome of human.


ZNG1E_HUMAN Zinc-regulated GTPase metalloprotein activator 1E (sprot)

A zinc-regulated GTPase metalloprotein activator 1E that is encoded in the genome of human.


ENV_HV1H2 Envelope glycoprotein gp160 (sprot)

An HIV env gene translation product that is encoded in the genome of human immunodeficiency virus type 1 group M subtype B (isolate HXB2).


TM260_HUMAN Protein O-mannosyl-transferase TMEM260 (sprot)

A protein O-mannosyl-transferase TMEM260 that is encoded in the genome of human.


MPEG1_HUMAN Macrophage-expressed gene 1 protein (sprot)

A macrophage-expressed gene 1 protein that is encoded in the genome of human.


FACE1_HUMAN CAAX prenyl protease 1 homolog (sprot)

A CAAX prenyl protease 1 that is encoded in the genome of human.


ICMT_HUMAN Protein-S-isoprenylcysteine O-methyltransferase (sprot)

A protein-S-isoprenylcysteine O-methyltransferase that is encoded in the genome of human.


PTPB_MYCTU Triple specificity protein phosphatase PtpB (sprot)


viral protein processing

Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein.


regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.


symbiont-mediated suppression of host programmed cell death

A process in which a symbiont gene product inhibits host programmed cell death, leading to a decrease in the frequency, rate or extent of programmed cell death in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.


perturbation by virus of host immune response

A process in which a virus effects a change in the host immune response.


lipopolysaccharide binding

Binding to a lipopolysaccharide.


C-5 sterol desaturase activity

Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.


ADP-riboxanase activity

Catalysis of the reaction: L-arginyl-[protein] + NAD+ = ADP-riboxanated L-argininyl-[protein] + H+ + NH4(+) + nicotinamide.


vitamin D3 25-hydroxylase activity

Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O.


oxidoreductase activity, acting on a sulfur group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


peptide antigen binding

Binding to an antigen peptide.


1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity

Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol).


endolysosome membrane

The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.


early endosome lumen

The volume enclosed by the membrane of an early endosome.


meiosis II

The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II.


R1AB_SARS2 Replicase polyprotein 1ab (sprot)


NTRK3_HUMAN NT-3 growth factor receptor (sprot)

An NT-3 growth factor receptor that is encoded in the genome of human.


ZDH17_HUMAN Palmitoyltransferase ZDHHC17 (sprot)

A palmitoyltransferase ZDHHC17 that is encoded in the genome of human.


COPC_CHRVO Arginine ADP-riboxanase CopC (sprot)


CARM1_HUMAN Histone-arginine methyltransferase CARM1 (sprot)

A histone-arginine methyltransferase CARM1 that is encoded in the genome of human.


FBX9_HUMAN F-box only protein 9 (sprot)

An F-box only protein 9 that is encoded in the genome of human.


cellular homeostasis

Any process involved in the maintenance of an internal steady state at the level of the cell.


chondrocyte proliferation

The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.


mesodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.


fibroblast growth factor receptor activity

Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.


receptor catabolic process

The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.


regulation of fibroblast growth factor receptor signaling pathway

Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.


neural crest cell delamination

The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube.


FGF23_HUMAN Fibroblast growth factor 23 (sprot)

A fibroblast growth factor 23 that is encoded in the genome of human.


FGF19_HUMAN Fibroblast growth factor 19 (sprot)

A fibroblast growth factor 19 that is encoded in the genome of human.


FGFR4_HUMAN Fibroblast growth factor receptor 4 (sprot)

A fibroblast growth factor receptor 4 that is encoded in the genome of human.


fibroblast growth factor receptor 3 isoform 2 (human)

A fibroblast growth factor receptor 3 isoform 2 that is encoded in the genome of human.


fibroblast growth factor receptor 1 isoform h19 (human)

A fibroblast growth factor receptor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11362-19.


fibroblast growth factor receptor 1 isoform 1 (human)

A fibroblast growth factor receptor 1 isoform 1 that is encoded in the genome of human.


fibroblast growth factor receptor 3 isoform 1 (human)

A fibroblast growth factor receptor 3 isoform 1 that is encoded in the genome of human.


KALM_HUMAN Anosmin-1 (sprot)

An anosmin-1 that is encoded in the genome of human.


FGF9_HUMAN Fibroblast growth factor 9 (sprot)

A fibroblast growth factor 9 that is encoded in the genome of human.


FGF10_HUMAN Fibroblast growth factor 10 (sprot)

A fibroblast growth factor 10 that is encoded in the genome of human.


FGF16_HUMAN Fibroblast growth factor 16 (sprot)

A fibroblast growth factor 16 that is encoded in the genome of human.


fibroblast growth factor 17 isoform 1 (human)

A fibroblast growth factor 17 isoform 1 that is encoded in the genome of human.


FGF18_HUMAN Fibroblast growth factor 18 (sprot)

A fibroblast growth factor 18 that is encoded in the genome of human.


FGF1_HUMAN Fibroblast growth factor 1 (sprot)

A fibroblast growth factor 1 that is encoded in the genome of human.


FGF4_HUMAN Fibroblast growth factor 4 (sprot)

A fibroblast growth factor 4 that is encoded in the genome of human.


FGF6_HUMAN Fibroblast growth factor 6 (sprot)

A fibroblast growth factor 6 that is encoded in the genome of human.


FGF3_HUMAN Fibroblast growth factor 3 (sprot)

A fibroblast growth factor 3 that is encoded in the genome of human.


fibroblast growth factor 5 isoform Long (human)

A fibroblast growth factor 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12034-1.


FGF7_HUMAN Fibroblast growth factor 7 (sprot)

A fibroblast growth factor 7 that is encoded in the genome of human.


fibroblast growth factor receptor 2 isoform 1 (human)

A fibroblast growth factor receptor 2 isoform 1 that is encoded in the genome of human.


fibroblast growth factor receptor 2 isoform h12 (human)

A fibroblast growth factor receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21802-18.


fibroblast growth factor receptor 2 isoform h3 (human)

A fibroblast growth factor receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21802-3.


fibroblast growth factor receptor 2 isoform h5 (human)

A fibroblast growth factor receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21802-5.


fibroblast growth factor 8 isoform hFGF-8E (human)

A fibroblast growth factor 8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55075-1.


FGFP1_HUMAN Fibroblast growth factor-binding protein 1 (sprot)

A fibroblast growth factor-binding protein 1 that is encoded in the genome of human.


FGFP3_HUMAN Fibroblast growth factor-binding protein 3 (sprot)

A fibroblast growth factor-binding protein 3 that is encoded in the genome of human.


FGFP2_HUMAN Fibroblast growth factor-binding protein 2 (sprot)

A fibroblast growth factor-binding protein 2 that is encoded in the genome of human.


FGF22_HUMAN Fibroblast growth factor 22 (sprot)

A fibroblast growth factor 22 that is encoded in the genome of human.


FGF20_HUMAN Fibroblast growth factor 20 (sprot)

A fibroblast growth factor 20 that is encoded in the genome of human.


regulation of bone mineralization

Any process that modulates the frequency, rate or extent of bone mineralization.


bone regeneration

The regrowth of bone following its loss or destruction.


positive regulation of nitric oxide mediated signal transduction

Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).


dorsal aorta development

The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.


somite specification

The process in which individual somites establish identity during embryogenesis.


ventral spinal cord interneuron differentiation

The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.


arterial endothelial cell differentiation

The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries.


sclerotome development

The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.


digestive tract morphogenesis

The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.


lateral inhibition

Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.


somatic motor neuron differentiation

The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


mitochondrial transcription

The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.


regulation of mitochondrial transcription

Any process that modulates the frequency, rate or extent of transcription occuring in the mitochondrion.


G2 phase

The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).


M phase

A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.


mitochondrial nucleoid

The region of a mitochondrion to which the DNA is confined.


mesoderm migration involved in gastrulation

The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.


spinal cord association neuron specification

The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway.


somatic motor neuron fate commitment

The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons.


cellular response to salt stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


cellular response to biotin starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of biotin.


aortic endothelial cell

An arterial endothelial cell that is part of the aorta endothelium.


DEGS2_HUMAN Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 (sprot)

A sphingolipid Delta(4)-desaturase/C4-monooxygenase DES2 that is encoded in the genome of human.


ZN750_HUMAN Zinc finger protein 750 (sprot)

A zinc finger protein 750 that is encoded in the genome of human.


ELOV7_HUMAN Very long chain fatty acid elongase 7 (sprot)

A very long chain fatty acid elongase 7 that is encoded in the genome of human.


NSMA2_HUMAN Sphingomyelin phosphodiesterase 3 (sprot)

A sphingomyelin phosphodiesterase 3 that is encoded in the genome of human.


ELOV6_HUMAN Very long chain fatty acid elongase 6 (sprot)

A very long chain fatty acid elongase 6 that is encoded in the genome of human.


VEGFA_HUMAN Vascular endothelial growth factor A, long form (sprot)

A vascular endothelial growth factor A, long form that is encoded in the genome of human.


KIT_HUMAN Mast/stem cell growth factor receptor Kit (sprot)

A mast/stem cell growth factor receptor that is encoded in the genome of human.


GLHA_HUMAN Glycoprotein hormones alpha chain (sprot)

A glycoprotein hormones alpha chain that is encoded in the genome of human.


CGB3_HUMAN Choriogonadotropin subunit beta 3 (sprot)

A choriogonadotropin subunit beta that is a translation product of any of the following genes in human: CGB3/CGB5/CGB8.


DEK_HUMAN Protein DEK (sprot)

A protein DEK that is encoded in the genome of human.


KDM5B_HUMAN Lysine-specific demethylase 5B (sprot)

A lysine-specific demethylase 5B that is encoded in the genome of human.


ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (sprot)

An ATPase family AAA domain-containing protein 2 that is encoded in the genome of human.


cellular response to caloric restriction

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake.


response to temperature stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.


photoperiodism

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species.


cellular response to cold

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.


aortic valve morphogenesis

The process in which the structure of the aortic valve is generated and organized.


cellular response to hydrostatic pressure

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it.


long-term synaptic depression

A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.


response to cold

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.


intracellular potassium ion homeostasis

A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell.


cellular response to iron ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.


response to acidic pH

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.


cellular hyperosmotic salinity response

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


positive regulation of sodium ion transport

Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


response to arsenic-containing substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.


cellular response to pheromone

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.


cellular response to freezing

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius.


cellular response to arsenic-containing substance

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.


positive regulation of fatty acid beta-oxidation

Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.


cellular response to chemical stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.


positive regulation of phosphatidylserine biosynthetic process

Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process.


positive regulation of inositol biosynthetic process

Any process that activates or increases the frequency, rate or extent of inositol biosynthetic process.


positive regulation of phosphatidylcholine biosynthetic process

Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process.


cellular response to alkaline pH

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.


cellular hypotonic response

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.


positive regulation of pseudohyphal growth

Any process that activates or increases the frequency, rate or extent of pseudohyphal growth.


positive regulation of invasive growth in response to glucose limitation

Any process that activates or increases the frequency, rate or extent of invasive growth in response to glucose limitation.


cellular response to acidic pH

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.


positive regulation of starch catabolic process

Any process that activates or increases the frequency, rate or extent of starch catabolic process.


positive regulation of flocculation

Any process that activates or increases the frequency, rate or extent of flocculation.


cellular response to iron ion starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.


cellular response to cobalt ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.


positive regulation of unsaturated fatty acid biosynthetic process

Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process.


cellular stress response to acidic pH

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.


cellular response to nitrosative stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.


cellular response to salt

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.


positive regulation of ergosterol biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.


positive regulation of mating type switching

Any process that activates or increases the frequency, rate or extent of mating type switching.


positive regulation of filamentous growth of a population of unicellular organisms in response to starvation

Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation.


positive regulation of sterol import

Any process that activates or increases the frequency, rate or extent of sterol import.


positive regulation of peroxisome organization

Any process that activates or increases the frequency, rate or extent of peroxisome organization.


stress response to copper ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus.


positive regulation of sulfate assimilation

Any process that activates or increases the frequency, rate or extent of sulfate assimilation.


positive regulation of arginine biosynthetic process

Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process.


positive regulation of glyoxylate cycle

Any process that activates or increases the frequency, rate or extent of glyoxylate cycle.


cellular response to methylglyoxal

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.


random inactivation of X chromosome

Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex.


catecholamine secretion

The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


trans-synaptic signaling by BDNF

Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft.


sulfite transport

The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


3',5'-cyclic AMP

A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase.


MEN1_HUMAN Menin (sprot)

A menin that is encoded in the genome of human.


JUNB_HUMAN Transcription factor JunB (sprot)

A transcription factor JunB that is encoded in the genome of human.


PITX2_HUMAN Pituitary homeobox 2 (sprot)

A pituitary homeobox 2 that is encoded in the genome of human.


AP2C_HUMAN Transcription factor AP-2 gamma (sprot)

A transcription factor AP-2 gamma that is encoded in the genome of human.


YETS4_HUMAN YEATS domain-containing protein 4 (sprot)

A YEATS domain-containing protein 4 that is encoded in the genome of human.


CITE1_HUMAN Cbp/p300-interacting transactivator 1 (sprot)

A Cbp/p300-interacting transactivator 1 that is encoded in the genome of human.


CITE2_HUMAN Cbp/p300-interacting transactivator 2 (sprot)

A Cbp/p300-interacting transactivator 2 that is encoded in the genome of human.


AP2A_HUMAN Transcription factor AP-2-alpha (sprot)

A transcription factor AP-2-alpha that is encoded in the genome of human.


AP2E_HUMAN Transcription factor AP-2-epsilon (sprot)

A transcription factor AP-2-epsilon that is encoded in the genome of human.


AP2D_HUMAN Transcription factor AP-2-delta (sprot)

A transcription factor AP-2-delta that is encoded in the genome of human.


AP2B_HUMAN Transcription factor AP-2-beta (sprot)

A transcription factor AP-2-beta that is encoded in the genome of human.


CITE4_HUMAN Cbp/p300-interacting transactivator 4 (sprot)

A Cbp/p300-interacting transactivator 4 that is encoded in the genome of human.


sporulation

The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.


re-entry into mitotic cell cycle after pheromone arrest

The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae.


nuclear factor of activated T-cells, cytoplasmic 2 isoform 3 (mouse)

A nuclear factor of activated T-cells, cytoplasmic 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60591-3.


nuclear factor of activated T-cells, cytoplasmic 2 isoform 2 (mouse)

A nuclear factor of activated T-cells, cytoplasmic 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60591-2.


protein PML isoform m3 (mouse)

A protein PML (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence encoded in exons 1-4, 6 and 7 and part of exon 9 of the PML gene.


short stature homeobox protein 2 isoform 1 (mouse)

A short stature homeobox protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70390-1.


short stature homeobox protein 2 isoform 2 (mouse)

A short stature homeobox protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70390-2.


tumor protein 63 isoform 3 (mouse)

A tumor protein 63 isoform 3 that is encoded in the genome of mouse.


tumor protein 63 isoform 5 (mouse)

A tumor protein 63 isoform 5 that is encoded in the genome of mouse.


myocardin isoform 1 (mouse)

A myocardin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8VIM5-1.


high mobility group nucleosome-binding domain-containing protein 3 isoform 2 (mouse)

A high mobility group nucleosome-binding domain-containing protein 3 isoform 2 that is encoded in the genome of mouse.


paired box protein Pax-6 isoform 1 (mouse)

A paired box protein Pax-6 isoform 1 that is encoded in the genome of mouse.


peroxisome proliferator-activated receptor gamma isoform 1 (mouse)

A peroxisome proliferator-activated receptor gamma (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37238-2.


retinoic acid receptor beta isoform 4 (mouse)

A retinoic acid receptor beta isoform 4 that is encoded in the genome of mouse.


retinoic acid receptor RXR-gamma isoform 1 (mouse)

A retinoic acid receptor RXR-gamma (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28705-1.


E9Q9V9_MOUSE Retinoic acid receptor RXR-gamma (trembl)

A retinoic acid receptor RXR-gamma (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:E9Q9V9.


Q6LC96_MOUSE Retinoic acid receptor RXR (trembl)

A retinoic acid receptor RXR-alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6LC96.


retinoic acid receptor RXR-alpha isoform 1 (mouse)

A retinoic acid receptor RXR-alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28700-1.


SMAD protein complex

A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven.


determination of ventral identity

The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


regulation of hormone levels

Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.


fibronectin fibril organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a fibronectin fibril.


common myeloid progenitor

A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.


COE1_HUMAN Transcription factor COE1 (sprot)

A transcription factor COE1 that is encoded in the genome of human.


LHX2_HUMAN LIM/homeobox protein Lhx2 (sprot)

A LIM/homeobox protein Lhx2 that is encoded in the genome of human.


RTP2_HUMAN Receptor-transporting protein 2 (sprot)

A receptor-transporting protein 2 that is encoded in the genome of human.


OR2M5_HUMAN Olfactory receptor 2M5 (sprot)

An olfactory receptor 2M5 that is encoded in the genome of human.


O2A25_HUMAN Olfactory receptor 2A25 (sprot)

An olfactory receptor 2A25 that is encoded in the genome of human.


O6C74_HUMAN Olfactory receptor 6C74 (sprot)

An olfactory receptor 6C74 that is encoded in the genome of human.


O14I1_HUMAN Olfactory receptor 14I1 (sprot)

An olfactory receptor 14I1 that is encoded in the genome of human.


O5H15_HUMAN Olfactory receptor 5H15 (sprot)

An olfactory receptor 5H15 that is encoded in the genome of human.


O6C68_HUMAN Olfactory receptor 6C68 (sprot)

An olfactory receptor 6C68 that is encoded in the genome of human.


OR5K3_HUMAN Olfactory receptor 5K3 (sprot)

An olfactory receptor 5K3 that is encoded in the genome of human.


OR6C6_HUMAN Olfactory receptor 6C6 (sprot)

An olfactory receptor 6C6 that is encoded in the genome of human.


OR2W5_HUMAN Putative olfactory receptor 2W5 pseudogene (sprot)

A protein that is a translation product of the OR2W5 gene in human.


O51F1_HUMAN Olfactory receptor 51F1 (sprot)

An olfactory receptor 51F1 that is encoded in the genome of human.


OR2T8_HUMAN Olfactory receptor 2T8 (sprot)

An olfactory receptor 2T8 that is encoded in the genome of human.


O4C46_HUMAN Olfactory receptor 4C46 (sprot)

An olfactory receptor 4C46 that is encoded in the genome of human.


O5H14_HUMAN Olfactory receptor 5H14 (sprot)

An olfactory receptor 5H14 that is encoded in the genome of human.


O6C70_HUMAN Olfactory receptor 6C70 (sprot)

An olfactory receptor 6C70 that is encoded in the genome of human.


O6C65_HUMAN Olfactory receptor 6C65 (sprot)

An olfactory receptor 6C65 that is encoded in the genome of human.


OR5H1_HUMAN Olfactory receptor 5H1 (sprot)

An olfactory receptor 5H1 that is encoded in the genome of human.


O6C75_HUMAN Olfactory receptor 6C75 (sprot)

An olfactory receptor 6C75 that is encoded in the genome of human.


O5B21_HUMAN Olfactory receptor 5B21 (sprot)

An olfactory receptor 5B21 that is encoded in the genome of human.


O2AG2_HUMAN Olfactory receptor 2AG2 (sprot)

An olfactory receptor 2AG2 that is encoded in the genome of human.


O6C76_HUMAN Olfactory receptor 6C76 (sprot)

An olfactory receptor 6C76 that is encoded in the genome of human.


OR5K4_HUMAN Olfactory receptor 5K4 (sprot)

An olfactory receptor 5K4 that is encoded in the genome of human.


O52A4_HUMAN Olfactory receptor 52A4 (sprot)

A protein that is a translation product of the OR52A4P gene in human.


O4C45_HUMAN Olfactory receptor 4C45 (sprot)

An olfactory receptor 4C45 that is encoded in the genome of human.


O2AT4_HUMAN Olfactory receptor 2AT4 (sprot)

An olfactory receptor 2AT4 that is encoded in the genome of human.


OR7AH_HUMAN Olfactory receptor 7A17 (sprot)

An olfactory receptor 7A17 that is encoded in the genome of human.


OR1F1_HUMAN Olfactory receptor 1F1 (sprot)

An olfactory receptor 1F1 that is encoded in the genome of human.


OR2T1_HUMAN Olfactory receptor 2T1 (sprot)

An olfactory receptor 2T1 that is encoded in the genome of human.


O10H2_HUMAN Olfactory receptor 10H2 (sprot)

An olfactory receptor 10H2 that is encoded in the genome of human.


O10H3_HUMAN Olfactory receptor 10H3 (sprot)

An olfactory receptor 10H3 that is encoded in the genome of human.


OR7C2_HUMAN Olfactory receptor 7C2 (sprot)

An olfactory receptor 7C2 that is encoded in the genome of human.


OR1I1_HUMAN Olfactory receptor 1I1 (sprot)

An olfactory receptor 1I1 that is encoded in the genome of human.


OR2B3_HUMAN Putative olfactory receptor 2B3 (sprot)

A putative olfactory receptor 2B3 that is encoded in the genome of human.


OR2J3_HUMAN Olfactory receptor 2J3 (sprot)

An olfactory receptor 2J3 that is encoded in the genome of human.


OR2J2_HUMAN Olfactory receptor 2J2 (sprot)

An olfactory receptor 2J2 that is encoded in the genome of human.


OR7C1_HUMAN Olfactory receptor 7C1 (sprot)

An olfactory receptor 7C1 that is encoded in the genome of human.


OR7AA_HUMAN Olfactory receptor 7A10 (sprot)

An olfactory receptor 7A10 that is encoded in the genome of human.


OR2F2_HUMAN Olfactory receptor 2F2 (sprot)

An olfactory receptor 2F2 that is encoded in the genome of human.


OR6B1_HUMAN Olfactory receptor 6B1 (sprot)

An olfactory receptor 6B1 that is encoded in the genome of human.


O4F21_HUMAN Olfactory receptor 4F21 (sprot)

An olfactory receptor 4F21 that is encoded in the genome of human.


OR2A4_HUMAN Olfactory receptor 2A4 (sprot)

An olfactory receptor 2A4 that is encoded in the genome of human.


OR5F1_HUMAN Olfactory receptor 5F1 (sprot)

An olfactory receptor 5F1 that is encoded in the genome of human.


OR6A2_HUMAN Olfactory receptor 6A2 (sprot)

An olfactory receptor 6A2 that is encoded in the genome of human.


OR2C1_HUMAN Olfactory receptor 2C1 (sprot)

An olfactory receptor 2C1 that is encoded in the genome of human.


OR2H2_HUMAN Olfactory receptor 2H2 (sprot)

An olfactory receptor 2H2 that is encoded in the genome of human.


OR4A8_HUMAN Olfactory receptor 4A8 (sprot)

A class II olfactory receptor that is a translation product of the OR4A8 gene in human.


O5AL1_HUMAN Olfactory receptor 5AL1 (sprot)

An olfactory receptor 5AL1 that is encoded in the genome of human.


OR4Q2_HUMAN Olfactory receptor 4Q2 (sprot)

An olfactory receptor 4Q2 that is encoded in the genome of human.


OR5G3_HUMAN Olfactory receptor 5G3 (sprot)

An olfactory receptor 5G3 that is encoded in the genome of human.


O5AC1_HUMAN Olfactory receptor 5AC1 (sprot)

An olfactory receptor 5AC1 that is encoded in the genome of human.


O10J4_HUMAN Olfactory receptor 10J4 (sprot)

An olfactory receptor 10J4 that is encoded in the genome of human.


OR4E1_HUMAN Olfactory receptor 4E1 (sprot)

An olfactory receptor 4E1 that is encoded in the genome of human.


O52Z1_HUMAN Olfactory receptor 52Z1P (sprot)

An olfactory receptor 52Z1P that is encoded in the genome of human.


OR8U8_HUMAN Olfactory receptor 8U8 (sprot)

An olfactory receptor 8U8 that is encoded in the genome of human.


OR8U9_HUMAN Olfactory receptor 8U9 (sprot)

A class II olfactory receptor that is a translation product of the OR8U9 gene in human.


OR9G9_HUMAN Olfactory receptor 9G9 (sprot)

An olfactory receptor 9G9 that is encoded in the genome of human.


OR2T7_HUMAN Olfactory receptor 2T7 (sprot)

An olfactory receptor 2T7 that is encoded in the genome of human.


O56A5_HUMAN Olfactory receptor 56A5 (sprot)

An olfactory receptor 56A5 that is encoded in the genome of human.


OR1E1_HUMAN Olfactory receptor 1E1 (sprot)

An olfactory receptor 1E1 that is encoded in the genome of human.


O10J1_HUMAN Olfactory receptor 10J1 (sprot)

An olfactory receptor 10J1 that is encoded in the genome of human.


OR1D2_HUMAN Olfactory receptor 1D2 (sprot)

An olfactory receptor 1D2 that is encoded in the genome of human.


OR3A1_HUMAN Olfactory receptor 3A1 (sprot)

An olfactory receptor 3A1 that is encoded in the genome of human.


OR1D4_HUMAN Olfactory receptor 1D4 (sprot)

An olfactory receptor 1D4 that is encoded in the genome of human.


OR1E2_HUMAN Olfactory receptor 1E2 (sprot)

An olfactory receptor 1E2 that is encoded in the genome of human.


OR3A3_HUMAN Olfactory receptor 3A3 (sprot)

An olfactory receptor 3A3 that is encoded in the genome of human.


OR1G1_HUMAN Olfactory receptor 1G1 (sprot)

An olfactory receptor 1G1 that is encoded in the genome of human.


OR3A2_HUMAN Olfactory receptor 3A2 (sprot)

An olfactory receptor 3A2 that is encoded in the genome of human.


OR1D5_HUMAN Olfactory receptor 1D5 (sprot)

An olfactory receptor 1D5 that is encoded in the genome of human.


OR2B6_HUMAN Olfactory receptor 2B6 (sprot)

An olfactory receptor 2B6 that is encoded in the genome of human.


OR4D2_HUMAN Olfactory receptor 4D2 (sprot)

An olfactory receptor 4D2 that is encoded in the genome of human.


O10A3_HUMAN Olfactory receptor 10A3 (sprot)

An olfactory receptor 10A3 that is encoded in the genome of human.


O12D2_HUMAN Olfactory receptor 12D2 (sprot)

An olfactory receptor 12D2 that is encoded in the genome of human.


OR5I1_HUMAN Olfactory receptor 5I1 (sprot)

An olfactory receptor 5I1 that is encoded in the genome of human.


OR2F1_HUMAN Olfactory receptor 2F1 (sprot)

An olfactory receptor 2F1 that is encoded in the genome of human.


OR1Q1_HUMAN Olfactory receptor 1Q1 (sprot)

An olfactory receptor 1Q1 that is encoded in the genome of human.


OR4D1_HUMAN Olfactory receptor 4D1 (sprot)

An olfactory receptor 4D1 that is encoded in the genome of human.


OR8G1_HUMAN Olfactory receptor 8G1 (sprot)

An olfactory receptor 8G1 that is encoded in the genome of human.


OR1C1_HUMAN Olfactory receptor 1C1 (sprot)

An olfactory receptor 1C1 that is encoded in the genome of human.


OR8B8_HUMAN Olfactory receptor 8B8 (sprot)

An olfactory receptor 8B8 that is encoded in the genome of human.


OR7A5_HUMAN Olfactory receptor 7A5 (sprot)

An olfactory receptor 7A5 that is encoded in the genome of human.


OR2BB_HUMAN Olfactory receptor 2B11 (sprot)

An olfactory receptor 2B11 that is encoded in the genome of human.


O10J3_HUMAN Olfactory receptor 10J3 (sprot)

An olfactory receptor 10J3 that is encoded in the genome of human.


OR2G6_HUMAN Olfactory receptor 2G6 (sprot)

An olfactory receptor 2G6 that is encoded in the genome of human.


OR5MA_HUMAN Olfactory receptor 5M10 (sprot)

An olfactory receptor 5M10 that is encoded in the genome of human.


OR4CB_HUMAN Olfactory receptor 4C11 (sprot)

An olfactory receptor 4C11 that is encoded in the genome of human.


OR4F3_HUMAN Olfactory receptor 4F3/4F16/4F29 (sprot)

An olfactory receptor 4F3/4F16/4F29 that is encoded in the genome of human.


OR2T5_HUMAN Olfactory receptor 2T5 (sprot)

An olfactory receptor 2T5 that is encoded in the genome of human.


OR2T2_HUMAN Olfactory receptor 2T2 (sprot)

An olfactory receptor 2T2 that is encoded in the genome of human.


O8G2P_HUMAN Putative olfactory receptor 8G2 (sprot)

A putative olfactory receptor 8G2 that is encoded in the genome of human.


OR2A2_HUMAN Olfactory receptor 2A2 (sprot)

An olfactory receptor 2A2 that is encoded in the genome of human.


O52W1_HUMAN Olfactory receptor 52W1 (sprot)

An olfactory receptor 52W1 that is encoded in the genome of human.


O4A47_HUMAN Olfactory receptor 4A47 (sprot)

An olfactory receptor 4A47 that is encoded in the genome of human.


O10K2_HUMAN Olfactory receptor 10K2 (sprot)

An olfactory receptor 10K2 that is encoded in the genome of human.


O52E8_HUMAN Olfactory receptor 52E8 (sprot)

An olfactory receptor 52E8 that is encoded in the genome of human.


OR6B2_HUMAN Olfactory receptor 6B2 (sprot)

An olfactory receptor 6B2 that is encoded in the genome of human.


O7E24_HUMAN Olfactory receptor 7E24 (sprot)

An olfactory receptor 7E24 that is encoded in the genome of human.


OR2W3_HUMAN Olfactory receptor 2W3 (sprot)

An olfactory receptor 2W3 that is encoded in the genome of human.


OR4N5_HUMAN Olfactory receptor 4N5 (sprot)

An olfactory receptor 4N5 that is encoded in the genome of human.


OR4N4_HUMAN Olfactory receptor 4N4 (sprot)

An olfactory receptor 4N4 that is encoded in the genome of human.


OR8I2_HUMAN Olfactory receptor 8I2 (sprot)

An olfactory receptor 8I2 that is encoded in the genome of human.


O5AS1_HUMAN Olfactory receptor 5AS1 (sprot)

An olfactory receptor 5AS1 that is encoded in the genome of human.


OR8H3_HUMAN Olfactory receptor 8H3 (sprot)

An olfactory receptor 8H3 that is encoded in the genome of human.


OR6V1_HUMAN Olfactory receptor 6V1 (sprot)

An olfactory receptor 6V1 that is encoded in the genome of human.


OR8H2_HUMAN Olfactory receptor 8H2 (sprot)

An olfactory receptor 8H2 that is encoded in the genome of human.


OR2LD_HUMAN Olfactory receptor 2L13 (sprot)

An olfactory receptor 2L13 that is encoded in the genome of human.


OR2C3_HUMAN Olfactory receptor 2C3 (sprot)

An olfactory receptor 2C3 that is encoded in the genome of human.


OR5T1_HUMAN Olfactory receptor 5T1 (sprot)

An olfactory receptor 5T1 that is encoded in the genome of human.


O2T33_HUMAN Olfactory receptor 2T33 (sprot)

An olfactory receptor 2T33 that is encoded in the genome of human.


O2T12_HUMAN Olfactory receptor 2T12 (sprot)

An olfactory receptor 2T12 that is encoded in the genome of human.


OR8G5_HUMAN Olfactory receptor 8G5 (sprot)

An olfactory receptor 8G5 that is encoded in the genome of human.


OR2L5_HUMAN Olfactory receptor 2L5 (sprot)

An olfactory receptor 2L5 that is encoded in the genome of human.


OR2M7_HUMAN Olfactory receptor 2M7 (sprot)

An olfactory receptor 2M7 that is encoded in the genome of human.