CD38_HUMAN ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (sprot)

An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 that is encoded in the genome of human.


PCFT_HUMAN Proton-coupled folate transporter (sprot)

A proton-coupled folate transporter that is encoded in the genome of human.


S19A1_HUMAN Reduced folate transporter (sprot)

A reduced folate transporter that is encoded in the genome of human.


S22AD_HUMAN Solute carrier family 22 member 13 (sprot)

A solute carrier family 22 member 13 that is encoded in the genome of human.


SC5A8_HUMAN Sodium-coupled monocarboxylate transporter 1 (sprot)

A sodium-coupled monocarboxylate transporter 1 that is encoded in the genome of human.


MDR3_HUMAN Phosphatidylcholine translocator ABCB4 (sprot)

A phosphatidylcholine translocator ABCB4 that is encoded in the genome of human.


S27A1_HUMAN Long-chain fatty acid transport protein 1 (sprot)

A long-chain fatty acid transport protein 1 that is encoded in the genome of human.


PTPRZ_HUMAN Receptor-type tyrosine-protein phosphatase zeta (sprot)

A receptor-type tyrosine-protein phosphatase zeta that is encoded in the genome of human.


CATZ_HUMAN Cathepsin Z (sprot)

A cathepsin Z that is encoded in the genome of human.


S38A1_HUMAN Sodium-coupled neutral amino acid symporter 1 (sprot)

A sodium-coupled neutral amino acid symporter 1 that is encoded in the genome of human.


PERT_HUMAN Thyroid peroxidase (sprot)

A thyroid peroxidase that is encoded in the genome of human.


SC5A5_HUMAN Sodium/iodide cotransporter (sprot)

A sodium/iodide cotransporter that is encoded in the genome of human.


S38A2_HUMAN Sodium-coupled neutral amino acid symporter 2 (sprot)

A sodium-coupled neutral amino acid symporter 2 that is encoded in the genome of human.


AOC2_HUMAN Retina-specific copper amine oxidase (sprot)

A retina-specific copper amine oxidase that is encoded in the genome of human.


LRP1_HUMAN Prolow-density lipoprotein receptor-related protein 1 (sprot)

A low-density lipoprotein receptor-related protein 1 that is encoded in the genome of human.


solute carrier organic anion transporter family member 2B1 isoform h1 (human)

A solute carrier organic anion transporter family member 2B1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O94956-1.


S22A7_HUMAN Solute carrier family 22 member 7 (sprot)

A solute carrier family 22 member 7 that is encoded in the genome of human.


RPE65_HUMAN Retinoid isomerohydrolase (sprot)

A retinal pigment epithelium-specific 65 kDa protein that is encoded in the genome of human.


NCKX1_HUMAN Sodium/potassium/calcium exchanger 1 (sprot)

A sodium/potassium/calcium exchanger 1 that is encoded in the genome of human.


sodium-dependent phosphate transport protein 4 isoform h2 (human)

A sodium-dependent phosphate transport protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00476-2.


protein tweety homolog 1 isoform h3 (human)

A protein tweety homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H313-3.


ANO1_HUMAN Anoctamin-1 (sprot)

An anoctamin-1 that is encoded in the genome of human.


TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 (sprot)

A transient receptor potential cation channel TRPV1 that is encoded in the genome of human.


IOD3_HUMAN Thyroxine 5-deiodinase (sprot)

A thyroxine 5-deiodinase that is encoded in the genome of human.


PTPRA_HUMAN Receptor-type tyrosine-protein phosphatase alpha (sprot)

A receptor-type tyrosine-protein phosphatase alpha that is encoded in the genome of human.


CTR3_HUMAN Cationic amino acid transporter 3 (sprot)

A cationic amino acid transporter 3 that is encoded in the genome of human.


S36A1_HUMAN Proton-coupled amino acid transporter 1 (sprot)

A proton-coupled amino acid transporter 1 that is encoded in the genome of human.


SATT_HUMAN Neutral amino acid transporter A (sprot)

A neutral amino acid transporter A that is encoded in the genome of human.


CTR1_HUMAN High affinity cationic amino acid transporter 1 (sprot)

A high affinity cationic amino acid transporter 1 that is encoded in the genome of human.


S6A19_HUMAN Sodium-dependent neutral amino acid transporter B(0)AT1 (sprot)

A sodium-dependent neutral amino acid transporter B(0)AT1 that is encoded in the genome of human.


S38A5_HUMAN Sodium-coupled neutral amino acid transporter 5 (sprot)

A sodium-coupled neutral amino acid transporter 5 that is encoded in the genome of human.


cationic amino acid transporter 2 isoform 1 (human)

A cationic amino acid transporter 2 isoform 1 that is encoded in the genome of human.


cationic amino acid transporter 2 isoform h2 (human)

A cationic amino acid transporter 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P52569-2.


LAT4_HUMAN Large neutral amino acids transporter small subunit 4 (sprot)

A large neutral amino acids transporter small subunit 4 that is encoded in the genome of human.


S36A4_HUMAN Neutral amino acid uniporter 4 (sprot)

A neutral amino acid uniporter 4 that is encoded in the genome of human.


S6A12_HUMAN Sodium- and chloride-dependent betaine transporter (sprot)

A sodium- and chloride-dependent betaine transporter that is encoded in the genome of human.


S38A3_HUMAN Sodium-coupled neutral amino acid transporter 3 (sprot)

A sodium-coupled neutral amino acid transporter 3 that is encoded in the genome of human.


S6A18_HUMAN Inactive sodium-dependent neutral amino acid transporter B(0)AT3 (sprot)

An inactive sodium-dependent neutral amino acid transporter B(0)AT3 that is encoded in the genome of human.


S36A2_HUMAN Proton-coupled amino acid transporter 2 (sprot)

A proton-coupled amino acid transporter 2 that is encoded in the genome of human.


LAT3_HUMAN Large neutral amino acids transporter small subunit 3 (sprot)

A large neutral amino acids transporter small subunit 3 that is encoded in the genome of human.


S38A4_HUMAN Sodium-coupled neutral amino acid transporter 4 (sprot)

A sodium-coupled neutral amino acid transporter 4 that is encoded in the genome of human.


AAAT_HUMAN Neutral amino acid transporter B(0) (sprot)

A neutral amino acid transporter B(0) that is encoded in the genome of human.


S6A14_HUMAN Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (sprot)

A sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) that is encoded in the genome of human.


S6A15_HUMAN Sodium-dependent neutral amino acid transporter B(0)AT2 (sprot)

A sodium-dependent neutral amino acid transporter B(0)AT2 that is encoded in the genome of human.


MOT10_HUMAN Monocarboxylate transporter 10 (sprot)

A monocarboxylate transporter 10 that is encoded in the genome of human.


SC6A6_HUMAN Sodium- and chloride-dependent taurine transporter (sprot)

A sodium- and chloride-dependent taurine transporter that is encoded in the genome of human.


TOMT_HUMAN Transmembrane O-methyltransferase (sprot)

A transmembrane O-methyltransferase that is encoded in the genome of human.


ECE1_HUMAN Endothelin-converting enzyme 1 (sprot)

An endothelin-converting enzyme 1 that is encoded in the genome of human.


SC6A3_HUMAN Sodium-dependent dopamine transporter (sprot)

A sodium-dependent dopamine transporter that is encoded in the genome of human.


DPP4_HUMAN Dipeptidyl peptidase 4 (sprot)

A dipeptidyl peptidase 4 that is encoded in the genome of human.


CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (sprot)

A cystic fibrosis transmembrane conductance regulator that is encoded in the genome of human.


ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein 10 (sprot)

A disintegrin and metalloproteinase domain-containing protein 10 that is encoded in the genome of human.


SOAT_HUMAN Sodium-dependent organic anion transporter (sprot)

A sodium-dependent organic anion transporter that is encoded in the genome of human.


S4A4_HUMAN Electrogenic sodium bicarbonate cotransporter 1 (sprot)

An electrogenic sodium bicarbonate cotransporter 1 that is encoded in the genome of human.


NCLX_HUMAN Mitochondrial sodium/calcium exchanger protein (sprot)

A mitochondrial sodium/calcium exchanger protein that is encoded in the genome of human.


ZNT10_HUMAN Calcium/manganese antiporter SLC30A10 (sprot)

A calcium/manganese antiporter SLC30A10 that is encoded in the genome of human.


COPT1_HUMAN High affinity copper uptake protein 1 (sprot)

A high affinity copper uptake protein 1 that is encoded in the genome of human.


NRAM2_HUMAN Natural resistance-associated macrophage protein 2 (sprot)

A natural resistance-associated macrophage protein 2 that is encoded in the genome of human.


NPT2C_HUMAN Sodium-dependent phosphate transport protein 2C (sprot)

A sodium-dependent phosphate transport protein 2C that is encoded in the genome of human.


S2611_HUMAN Sodium-independent sulfate anion transporter (sprot)

A sodium-independent sulfate anion transporter that is encoded in the genome of human.


S26A4_HUMAN Pendrin (sprot)

A pendrin that is encoded in the genome of human.


SC5AC_HUMAN Sodium-coupled monocarboxylate transporter 2 (sprot)

A sodium-coupled monocarboxylate transporter 2 that is encoded in the genome of human.


NPT1_HUMAN Sodium-dependent phosphate transport protein 1 (sprot)

A sodium-dependent phosphate transport protein 1 that is encoded in the genome of human.


MYCT_HUMAN Proton myo-inositol cotransporter (sprot)

A proton myo-inositol cotransporter that is encoded in the genome of human.


SC5A3_HUMAN Sodium/myo-inositol cotransporter (sprot)

A sodium/myo-inositol cotransporter that is encoded in the genome of human.


SC5AB_HUMAN Sodium/myo-inositol cotransporter 2 (sprot)

A sodium/myo-inositol cotransporter 2 that is encoded in the genome of human.


S13A4_HUMAN Solute carrier family 13 member 4 (sprot)

A solute carrier family 13 member 4 that is encoded in the genome of human.


S13A2_HUMAN Solute carrier family 13 member 2 (sprot)

A solute carrier family 13 member 2 that is encoded in the genome of human.


S13A1_HUMAN Solute carrier family 13 member 1 (sprot)

A solute carrier family 13 member 1 that is encoded in the genome of human.


S13A3_HUMAN Na(+)/dicarboxylate cotransporter 3 (sprot)

A Na(+)/dicarboxylate cotransporter 3 that is encoded in the genome of human.


S13A5_HUMAN Na(+)/citrate cotransporter (sprot)

A Na(+)/citrate cotransporter that is encoded in the genome of human.


LRP8_HUMAN Low-density lipoprotein receptor-related protein 8 (sprot)

A low-density lipoprotein receptor-related protein 8 that is encoded in the genome of human.


ZNT1_HUMAN Proton-coupled zinc antiporter SLC30A1 (sprot)

A proton-coupled zinc antiporter SLC30A1 that is encoded in the genome of human.


S39A5_HUMAN Zinc transporter ZIP5 (sprot)

A zinc transporter ZIP5 that is encoded in the genome of human.


S39AA_HUMAN Zinc transporter ZIP10 (sprot)

A zinc transporter ZIP10 that is encoded in the genome of human.


RHCG_HUMAN Ammonium transporter Rh type C (sprot)

An ammonium transporter Rh type C that is encoded in the genome of human.


RHBG_HUMAN Ammonium transporter Rh type B (sprot)

An ammonium transporter Rh type B that is encoded in the genome of human.


SC6A2_HUMAN Sodium-dependent noradrenaline transporter (sprot)

A sodium-dependent noradrenaline transporter that is encoded in the genome of human.


MAGT1_HUMAN Magnesium transporter protein 1 (sprot)

A magnesium transporter protein 1 that is encoded in the genome of human.


ANKH_HUMAN Mineralization regulator ANKH (sprot)

A progressive ankylosis protein that is encoded in the genome of human.


TUSC3_HUMAN Tumor suppressor candidate 3 (sprot)

A tumor suppressor candidate 3 that is encoded in the genome of human.


S22A3_HUMAN Solute carrier family 22 member 3 (sprot)

A solute carrier family 22 member 3 that is encoded in the genome of human.


S22A4_HUMAN Solute carrier family 22 member 4 (sprot)

A solute carrier family 22 member 4 that is encoded in the genome of human.


S22AC_HUMAN Solute carrier family 22 member 12 (sprot)

A solute carrier family 22 member 12 that is encoded in the genome of human.


CORIN_HUMAN Atrial natriuretic peptide-converting enzyme (sprot)

An atrial natriuretic peptide-converting enzyme that is encoded in the genome of human.


AT2B4_HUMAN Plasma membrane calcium-transporting ATPase 4 (sprot)

A plasma membrane calcium-transporting ATPase 4 that is encoded in the genome of human.


CTL1_HUMAN Choline transporter-like protein 1 (sprot)

A choline transporter-like protein 1 that is encoded in the genome of human.


PTPRJ_HUMAN Receptor-type tyrosine-protein phosphatase eta (sprot)

A receptor-type tyrosine-protein phosphatase eta that is encoded in the genome of human.


ST14_HUMAN Suppressor of tumorigenicity 14 protein (sprot)

A suppressor of tumorigenicity 14 protein that is encoded in the genome of human.


GDE1_HUMAN Glycerophosphodiester phosphodiesterase 1 (sprot)

A glycerophosphodiester phosphodiesterase 1 that is encoded in the genome of human.


ENPP6_HUMAN Glycerophosphocholine cholinephosphodiesterase ENPP6 (sprot)

A glycerophosphocholine cholinephosphodiesterase ENPP6 that is encoded in the genome of human.


PAI2_HUMAN Plasminogen activator inhibitor 2 (sprot)

A plasminogen activator inhibitor 2 that is encoded in the genome of human.


S29A4_HUMAN Equilibrative nucleoside transporter 4 (sprot)

An equilibrative nucleoside transporter 4 that is encoded in the genome of human.


S28A2_HUMAN Sodium/nucleoside cotransporter 2 (sprot)

A sodium/nucleoside cotransporter 2 that is encoded in the genome of human.


S28A3_HUMAN Solute carrier family 28 member 3 (sprot)

A solute carrier family 28 member 3 that is encoded in the genome of human.


S28A1_HUMAN Sodium/nucleoside cotransporter 1 (sprot)

A sodium/nucleoside cotransporter 1 that is encoded in the genome of human.


SO4C1_HUMAN Solute carrier organic anion transporter family member 4C1 (sprot)

A solute carrier organic anion transporter family member 4C1 that is encoded in the genome of human.


SO2A1_HUMAN Solute carrier organic anion transporter family member 2A1 (sprot)

A solute carrier organic anion transporter family member 2A1 that is encoded in the genome of human.


solute carrier organic anion transporter family member 3A1 isoform 1 (human)

A solute carrier organic anion transporter family member 3A1 isoform 1 that is encoded in the genome of human.


SO2B1_HUMAN Solute carrier organic anion transporter family member 2B1 (sprot)

A solute carrier organic anion transporter family member 2B1 that is encoded in the genome of human.


BLK_HUMAN Tyrosine-protein kinase Blk (sprot)

A tyrosine-protein kinase BLK that is encoded in the genome of human.


NAC3_HUMAN Sodium/calcium exchanger 3 (sprot)

A sodium/calcium exchanger 3 that is encoded in the genome of human.


LDLR_HUMAN Low-density lipoprotein receptor (sprot)

A low-density lipoprotein receptor that is encoded in the genome of human.


SC5A1_HUMAN Sodium/glucose cotransporter 1 (sprot)

A sodium/glucose cotransporter 1 that is encoded in the genome of human.


GTR5_HUMAN Solute carrier family 2, facilitated glucose transporter member 5 (sprot)

A solute carrier family 2, facilitated glucose transporter member 5 that is encoded in the genome of human.


TRPC3_HUMAN Short transient receptor potential channel 3 (sprot)

A short transient receptor potential cation channel TRPC3 that is encoded in the genome of human.


tyrosine-protein kinase Fyn isoform 1 (human)

A tyrosine-protein kinase Fyn isoform 1 that is encoded in the genome of human.


S22AH_HUMAN Solute carrier family 22 member 17 (sprot)

A solute carrier family 22 member 17 that is encoded in the genome of human.


ABCA6_HUMAN ATP-binding cassette sub-family A member 6 (sprot)

An ATP-binding cassette sub-family A member 6 that is encoded in the genome of human.


RASK_HUMAN GTPase KRas (sprot)

A GTPase KRas that is encoded in the genome of human.


KCNJ2_HUMAN Inward rectifier potassium channel 2 (sprot)

An inward rectifier potassium channel 2 that is encoded in the genome of human.


OTOP1_HUMAN Proton channel OTOP1 (sprot)

A proton channel OTOP1 that is encoded in the genome of human.


PLCB2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (sprot)

A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 that is encoded in the genome of human.


CHLE_HUMAN Cholinesterase (sprot)

A cholinesterase that is encoded in the genome of human.


CD320_HUMAN CD320 antigen (sprot)

A CD320 molecule that is encoded in the genome of human.


S22A1_HUMAN Solute carrier family 22 member 1 (sprot)

A solute carrier family 22 member 1 that is encoded in the genome of human.


ANO9_HUMAN Anoctamin-9 (sprot)

An anoctamin-9 that is encoded in the genome of human.


SERC4_HUMAN Serine incorporator 4 (sprot)

A serine incorporator 4 that is encoded in the genome of human.


CLCA1_HUMAN Calcium-activated chloride channel regulator 1 (sprot)

A calcium-activated chloride channel regulator 1 that is encoded in the genome of human.


HYAS3_HUMAN Hyaluronan synthase 3 (sprot)

A hyaluronan synthase 3 that is encoded in the genome of human.


PLPP3_HUMAN Phospholipid phosphatase 3 (sprot)

A phospholipid phosphatase 3 that is encoded in the genome of human.


PLD2_HUMAN Phospholipase D2 (sprot)

A phospholipase D2 that is encoded in the genome of human.


S22A2_HUMAN Solute carrier family 22 member 2 (sprot)

A solute carrier family 22 member 2 that is encoded in the genome of human.


AT8B1_HUMAN Phospholipid-transporting ATPase IC (sprot)

A phospholipid-transporting ATPase IC that is encoded in the genome of human.


PLPP2_HUMAN Phospholipid phosphatase 2 (sprot)

A phospholipid phosphatase 2 that is encoded in the genome of human.


ATP9B_HUMAN Probable phospholipid-transporting ATPase IIB (sprot)

A probable phospholipid-transporting ATPase IIB that is encoded in the genome of human.


AT10A_HUMAN Phospholipid-transporting ATPase VA (sprot)

A phospholipid-transporting ATPase VA that is encoded in the genome of human.


AT8B3_HUMAN Phospholipid-transporting ATPase IK (sprot)

A phospholipid-transporting ATPase IK that is encoded in the genome of human.


ABCC9_HUMAN ATP-binding cassette sub-family C member 9 (sprot)

An ATP-binding cassette sub-family C member 9 that is encoded in the genome of human.


S19A2_HUMAN Thiamine transporter 1 (sprot)

A thiamine transporter 1 that is encoded in the genome of human.


ATP9A_HUMAN Probable phospholipid-transporting ATPase IIA (sprot)

A probable phospholipid-transporting ATPase IIA that is encoded in the genome of human.


TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 (sprot)

A transient receptor potential cation channel TRPA1 that is encoded in the genome of human.


DGKI_HUMAN Diacylglycerol kinase iota (sprot)

A diacylglycerol kinase iota that is encoded in the genome of human.


TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 (sprot)

A transient receptor potential cation channel subfamily M member 2 that is encoded in the genome of human.


AT10B_HUMAN Phospholipid-transporting ATPase VB (sprot)

A phospholipid-transporting ATPase VB that is encoded in the genome of human.


MRP6_HUMAN ATP-binding cassette sub-family C member 6 (sprot)

An ATP-binding cassette sub-family C member 6 that is encoded in the genome of human.


NPT2B_HUMAN Sodium-dependent phosphate transport protein 2B (sprot)

A sodium-dependent phosphate transport protein 2B that is encoded in the genome of human.


VNN1_HUMAN Pantetheinase (sprot)

A pantetheinase that is encoded in the genome of human.


VNN2_HUMAN Pantetheine hydrolase VNN2 (sprot)

A pantetheine hydrolase VNN2 that is encoded in the genome of human.


GTR10_HUMAN Solute carrier family 2, facilitated glucose transporter member 10 (sprot)

A solute carrier family 2, facilitated glucose transporter member 10 that is encoded in the genome of human.


RASN_HUMAN GTPase NRas (sprot)

A GTPase NRas that is encoded in the genome of human.


B3AT_HUMAN Band 3 anion transport protein (sprot)

A band 3 anion transport protein that is encoded in the genome of human.


B3A2_HUMAN Anion exchange protein 2 (sprot)

An anion exchange protein 2 that is encoded in the genome of human.


GDN_HUMAN Glia-derived nexin (sprot)

A glia-derived nexin that is encoded in the genome of human.


GTR1_HUMAN Solute carrier family 2, facilitated glucose transporter member 1 (sprot)

A solute carrier family 2, facilitated glucose transporter member 1 that is encoded in the genome of human.


GRAH_HUMAN Granzyme H (sprot)

A granzyme H that is encoded in the genome of human.


ACES_HUMAN Acetylcholinesterase (sprot)

An acetylcholinesterase that is encoded in the genome of human.


DGKA_HUMAN Diacylglycerol kinase alpha (sprot)

A diacylglycerol kinase alpha that is encoded in the genome of human.


SC6A1_HUMAN Sodium- and chloride-dependent GABA transporter 1 (sprot)

A sodium- and chloride-dependent GABA transporter 1 that is encoded in the genome of human.


I5P2_HUMAN Type II inositol 1,4,5-trisphosphate 5-phosphatase (sprot)

A type II inositol 1,4,5-trisphosphate 5-phosphatase that is encoded in the genome of human.


NAC1_HUMAN Sodium/calcium exchanger 1 (sprot)

A sodium/calcium exchanger 1 that is encoded in the genome of human.


SPB6_HUMAN Serpin B6 (sprot)

A serpin B6 that is encoded in the genome of human.


CLCN1_HUMAN Chloride channel protein 1 (sprot)

A chloride channel protein, skeletal muscle that is encoded in the genome of human.


S26A3_HUMAN Chloride anion exchanger (sprot)

A chloride anion exchanger that is encoded in the genome of human.


EAA1_HUMAN Excitatory amino acid transporter 1 (sprot)

An excitatory amino acid transporter 1 that is encoded in the genome of human.


S15A1_HUMAN Solute carrier family 15 member 1 (sprot)

A solute carrier family 15 member 1 that is encoded in the genome of human.


SC6A8_HUMAN Sodium- and chloride-dependent creatine transporter 1 (sprot)

A sodium- and chloride-dependent creatine transporter 1 that is encoded in the genome of human.


S6A11_HUMAN Sodium- and chloride-dependent GABA transporter 3 (sprot)

A sodium- and chloride-dependent GABA transporter 3 that is encoded in the genome of human.


SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (sprot)

A sodium- and chloride-dependent glycine transporter 1 that is encoded in the genome of human.


B3A3_HUMAN Anion exchange protein 3 (sprot)

An anion exchange protein 3 that is encoded in the genome of human.


SL9A3_HUMAN Sodium/hydrogen exchanger 3 (sprot)

A sodium/hydrogen exchanger 3 that is encoded in the genome of human.


DGKG_HUMAN Diacylglycerol kinase gamma (sprot)

A diacylglycerol kinase gamma that is encoded in the genome of human.


S26A2_HUMAN Sulfate transporter (sprot)

A sulfate transporter that is encoded in the genome of human.


SPB8_HUMAN Serpin B8 (sprot)

A serpin B8 that is encoded in the genome of human.


MMP16_HUMAN Matrix metalloproteinase-16 (sprot)

A matrix metalloproteinase-16 that is encoded in the genome of human.


CLCN2_HUMAN Chloride channel protein 2 (sprot)

A chloride channel protein 2 that is encoded in the genome of human.


DGKE_HUMAN Diacylglycerol kinase epsilon (sprot)

A diacylglycerol kinase epsilon that is encoded in the genome of human.


DGKQ_HUMAN Diacylglycerol kinase theta (sprot)

A diacylglycerol kinase theta that is encoded in the genome of human.


AT11A_HUMAN Phospholipid-transporting ATPase IH (sprot)

A phospholipid-transporting ATPase IH that is encoded in the genome of human.


AT8B2_HUMAN Phospholipid-transporting ATPase ID (sprot)

A phospholipid-transporting ATPase ID that is encoded in the genome of human.


PLCB3_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (sprot)

A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 that is encoded in the genome of human.


NPT2A_HUMAN Sodium-dependent phosphate transport protein 2A (sprot)

A sodium-dependent phosphate transport protein 2A that is encoded in the genome of human.


S20A2_HUMAN Sodium-dependent phosphate transporter 2 (sprot)

A sodium-dependent phosphate transporter 2 that is encoded in the genome of human.


NIPA4_HUMAN Magnesium transporter NIPA4 (sprot)

A magnesium transporter NIPA4 that is encoded in the genome of human.


UT1_HUMAN Urea transporter 1 (sprot)

A urea transporter 1 that is encoded in the genome of human.


S39A6_HUMAN Zinc transporter ZIP6 (sprot)

A zinc transporter ZIP6 that is encoded in the genome of human.


ADAM9_HUMAN Disintegrin and metalloproteinase domain-containing protein 9 (sprot)

A disintegrin and metalloproteinase domain-containing protein 9 that is encoded in the genome of human.


ADA15_HUMAN Disintegrin and metalloproteinase domain-containing protein 15 (sprot)

A disintegrin and metalloproteinase domain-containing protein 15 that is encoded in the genome of human.


SERC3_HUMAN Serine incorporator 3 (sprot)

A serine incorporator 3 that is encoded in the genome of human.


DGKZ_HUMAN Diacylglycerol kinase zeta (sprot)

A diacylglycerol kinase zeta that is encoded in the genome of human.


S29A2_HUMAN Equilibrative nucleoside transporter 2 (sprot)

An equilibrative nucleoside transporter 2 that is encoded in the genome of human.


I5P1_HUMAN Inositol polyphosphate-5-phosphatase A (sprot)

An inositol polyphosphate-5-phosphatase A that is encoded in the genome of human.


SL9A5_HUMAN Sodium/hydrogen exchanger 5 (sprot)

A sodium/hydrogen exchanger 5 that is encoded in the genome of human.


CLCA4_HUMAN Calcium-activated chloride channel regulator 4 (sprot)

A calcium-activated chloride channel regulator 4 that is encoded in the genome of human.


S39AE_HUMAN Metal cation symporter ZIP14 (sprot)

A metal cation symporter ZIP14 that is encoded in the genome of human.


PLCB4_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (sprot)

A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 that is encoded in the genome of human.


UT2_HUMAN Urea transporter 2 (sprot)

A urea transporter 2 that is encoded in the genome of human.


DGKD_HUMAN Diacylglycerol kinase delta (sprot)

A diacylglycerol kinase delta that is encoded in the genome of human.


PTPRO_HUMAN Receptor-type tyrosine-protein phosphatase O (sprot)

A receptor-type tyrosine-protein phosphatase O that is encoded in the genome of human.


S4A8_HUMAN Electroneutral sodium bicarbonate exchanger 1 (sprot)

An electroneutral sodium bicarbonate exchanger 1 that is encoded in the genome of human.


ANO4_HUMAN Anoctamin-4 (sprot)

An anoctamin-4 that is encoded in the genome of human.


PLPR5_HUMAN Phospholipid phosphatase-related protein type 5 (sprot)

A phospholipid phosphatase-related protein type 5 that is encoded in the genome of human.


ANO6_HUMAN Anoctamin-6 (sprot)

An anoctamin-6 that is encoded in the genome of human.


AT135_HUMAN Probable cation-transporting ATPase 13A5 (sprot)

A probable cation-transporting ATPase 13A5 that is encoded in the genome of human.


AT134_HUMAN Probable cation-transporting ATPase 13A4 (sprot)

A probable cation-transporting ATPase 13A4 that is encoded in the genome of human.


SL9B1_HUMAN Sodium/hydrogen exchanger 9B1 (sprot)

A sodium/hydrogen exchanger 9B1 that is encoded in the genome of human.


CTL4_HUMAN Choline transporter-like protein 4 (sprot)

A choline transporter-like protein 4 that is encoded in the genome of human.


DGKK_HUMAN Diacylglycerol kinase kappa (sprot)

A diacylglycerol kinase kappa that is encoded in the genome of human.


MRP7_HUMAN ATP-binding cassette sub-family C member 10 (sprot)

An ATP-binding cassette sub-family C member 10 that is encoded in the genome of human.


SL9C2_HUMAN Sodium/hydrogen exchanger 11 (sprot)

A sodium/hydrogen exchanger 11 that is encoded in the genome of human.


MFS4B_HUMAN Sodium-dependent glucose transporter 1 (sprot)

A sodium-dependent glucose transporter 1 that is encoded in the genome of human.


PLPP4_HUMAN Phospholipid phosphatase 4 (sprot)

A phospholipid phosphatase 4 that is encoded in the genome of human.


SL9A4_HUMAN Sodium/hydrogen exchanger 4 (sprot)

A sodium/hydrogen exchanger 4 that is encoded in the genome of human.


ANO7_HUMAN Anoctamin-7 (sprot)

An anoctamin-7 that is encoded in the genome of human.


NIPA3_HUMAN Magnesium transporter NIPA3 (sprot)

A magnesium transporter NIPA3 that is encoded in the genome of human.


S27A4_HUMAN Long-chain fatty acid transport protein 4 (sprot)

A long-chain fatty acid transport protein 4 that is encoded in the genome of human.


NPAL3_HUMAN NIPA-like protein 3 (sprot)

A NIPA-like protein 3 that is encoded in the genome of human.


S39A4_HUMAN Zinc transporter ZIP4 (sprot)

A zinc transporter ZIP4 that is encoded in the genome of human.


GTR7_HUMAN Solute carrier family 2, facilitated glucose transporter member 7 (sprot)

A solute carrier family 2, facilitated glucose transporter member 7 that is encoded in the genome of human.


PLPR3_HUMAN Phospholipid phosphatase-related protein type 3 (sprot)

A phospholipid phosphatase-related protein type 3 that is encoded in the genome of human.


S4A10_HUMAN Sodium-driven chloride bicarbonate exchanger (sprot)

A sodium-driven chloride bicarbonate exchanger that is encoded in the genome of human.


LIPI_HUMAN Lipase member I (sprot)

A lipase member I that is encoded in the genome of human.


ANO5_HUMAN Anoctamin-5 (sprot)

An anoctamin-5 that is encoded in the genome of human.


S26A9_HUMAN Solute carrier family 26 member 9 (sprot)

A solute carrier family 26 member 9 that is encoded in the genome of human.


NIPA1_HUMAN Magnesium transporter NIPA1 (sprot)

A magnesium transporter NIPA1 that is encoded in the genome of human.


PLPR4_HUMAN Phospholipid phosphatase-related protein type 4 (sprot)

A phospholipid phosphatase-related protein type 4 that is encoded in the genome of human.


TRPM8_HUMAN Transient receptor potential cation channel subfamily M member 8 (sprot)

A transient receptor potential cation channel TRPM8 that is encoded in the genome of human.


LRP10_HUMAN Low-density lipoprotein receptor-related protein 10 (sprot)

A low-density lipoprotein receptor-related protein 10 that is encoded in the genome of human.


TRPM1_HUMAN Transient receptor potential cation channel subfamily M member 1 (sprot)

A transient receptor potential cation channel subfamily M member 1 that is encoded in the genome of human.


SERC5_HUMAN Serine incorporator 5 (sprot)

A serine incorporator 5 that is encoded in the genome of human.


S22AG_HUMAN Solute carrier family 22 member 16 (sprot)

A solute carrier family 22 member 16 that is encoded in the genome of human.


DGKH_HUMAN Diacylglycerol kinase eta (sprot)

A diacylglycerol kinase eta that is encoded in the genome of human.


TMPS6_HUMAN Transmembrane protease serine 6 (sprot)

A transmembrane protease serine 6 that is encoded in the genome of human.


ABCA9_HUMAN ATP-binding cassette sub-family A member 9 (sprot)

An ATP-binding cassette sub-family A member 9 that is encoded in the genome of human.


S41A1_HUMAN Solute carrier family 41 member 1 (sprot)

A solute carrier family 41 member 1 that is encoded in the genome of human.


CTL2_HUMAN Choline transporter-like protein 2 (sprot)

A choline transporter-like protein 2 that is encoded in the genome of human.


S22AF_HUMAN Solute carrier family 22 member 15 (sprot)

A solute carrier family 22 member 15 that is encoded in the genome of human.


BEST3_HUMAN Bestrophin-3 (sprot)

A bestrophin-3 that is encoded in the genome of human.


ABD12_HUMAN Lysophosphatidylserine lipase ABHD12 (sprot)

A lysophosphatidylserine lipase ABHD12 that is encoded in the genome of human.


CTL3_HUMAN Choline transporter-like protein 3 (sprot)

A choline transporter-like protein 3 that is encoded in the genome of human.


NIPA2_HUMAN Magnesium transporter NIPA2 (sprot)

A magnesium transporter NIPA2 that is encoded in the genome of human.


AT11C_HUMAN Phospholipid-transporting ATPase IG (sprot)

A phospholipid-transporting ATPase IG that is encoded in the genome of human.


DGLB_HUMAN Diacylglycerol lipase-beta (sprot)

A diacylglycerol lipase-beta that is encoded in the genome of human.


CTL5_HUMAN Choline transporter-like protein 5 (sprot)

A choline transporter-like protein 5 that is encoded in the genome of human.


PLPP5_HUMAN Phospholipid phosphatase 5 (sprot)

A phospholipid phosphatase 5 that is encoded in the genome of human.


TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (sprot)

A transient receptor potential cation channel TRPV3 that is encoded in the genome of human.


NCKX4_HUMAN Sodium/potassium/calcium exchanger 4 (sprot)

A sodium/potassium/calcium exchanger 4 that is encoded in the genome of human.


BEST4_HUMAN Bestrophin-4 (sprot)

A bestrophin-4 that is encoded in the genome of human.


BEST2_HUMAN Bestrophin-2 (sprot)

A bestrophin-2 that is encoded in the genome of human.


PLPR1_HUMAN Phospholipid phosphatase-related protein type 1 (sprot)

A phospholipid phosphatase-related protein type 1 that is encoded in the genome of human.


SPP2B_HUMAN Signal peptide peptidase-like 2B (sprot)

A signal peptide peptidase-like 2B that is encoded in the genome of human.


SPP2A_HUMAN Signal peptide peptidase-like 2A (sprot)

A signal peptide peptidase-like 2A that is encoded in the genome of human.


GTR12_HUMAN Solute carrier family 2, facilitated glucose transporter member 12 (sprot)

A solute carrier family 2, facilitated glucose transporter member 12 that is encoded in the genome of human.


TRPM4_HUMAN Transient receptor potential cation channel subfamily M member 4 (sprot)

A transient receptor potential cation channel subfamily M member 4 that is encoded in the genome of human.


MCLN3_HUMAN Mucolipin-3 (sprot)

A mucolipin-3 that is encoded in the genome of human.


S26A7_HUMAN Anion exchange transporter (sprot)

An anion exchange transporter that is encoded in the genome of human.


TP4AP_HUMAN Short transient receptor potential channel 4-associated protein (sprot)

A short transient receptor potential channel 4-associated protein that is encoded in the genome of human.


AT8B4_HUMAN Probable phospholipid-transporting ATPase IM (sprot)

A probable phospholipid-transporting ATPase IM that is encoded in the genome of human.


S20A1_HUMAN Sodium-dependent phosphate transporter 1 (sprot)

A sodium-dependent phosphate transporter 1 that is encoded in the genome of human.


LIPH_HUMAN Lipase member H (sprot)

A lipase member H that is encoded in the genome of human.


ABCAA_HUMAN ATP-binding cassette sub-family A member 10 (sprot)

An ATP-binding cassette sub-family A member 10 that is encoded in the genome of human.


HYAS2_HUMAN Hyaluronan synthase 2 (sprot)

A hyaluronan synthase 2 that is encoded in the genome of human.


HYAS1_HUMAN Hyaluronan synthase 1 (sprot)

A hyaluronan synthase 1 that is encoded in the genome of human.


SO4A1_HUMAN Solute carrier organic anion transporter family member 4A1 (sprot)

A solute carrier organic anion transporter family member 4A1 that is encoded in the genome of human.


PLD4_HUMAN 5'-3' exonuclease PLD4 (sprot)

A 5'-3' exonuclease PLD4 that is encoded in the genome of human.


PLPR2_HUMAN Phospholipid phosphatase-related protein type 2 (sprot)

A phospholipid phosphatase-related protein type 2 that is encoded in the genome of human.


MRP8_HUMAN ATP-binding cassette sub-family C member 11 (sprot)

An ATP-binding cassette sub-family C member 11 that is encoded in the genome of human.


S41A2_HUMAN Solute carrier family 41 member 2 (sprot)

A solute carrier family 41 member 2 that is encoded in the genome of human.


B3A4_HUMAN Anion exchange protein 4 (sprot)

An anion exchange protein 4 that is encoded in the genome of human.


TRPM7_HUMAN Transient receptor potential cation channel subfamily M member 7 (sprot)

A transient receptor potential cation channel subfamily M member 7 that is encoded in the genome of human.


SERC2_HUMAN Serine incorporator 2 (sprot)

A serine incorporator 2 that is encoded in the genome of human.


S29A1_HUMAN Equilibrative nucleoside transporter 1 (sprot)

An equilibrative nucleoside transporter 1 that is encoded in the genome of human.


S39A3_HUMAN Zinc transporter ZIP3 (sprot)

A zinc transporter ZIP3 that is encoded in the genome of human.


TTYH2_HUMAN Protein tweety homolog 2 (sprot)

A protein tweety homolog 2 that is encoded in the genome of human.


ABHD6_HUMAN Monoacylglycerol lipase ABHD6 (sprot)

A monoacylglycerol lipase ABHD6 that is encoded in the genome of human.


TRPM6_HUMAN Transient receptor potential cation channel subfamily M member 6 (sprot)

A transient receptor potential cation channel subfamily M member 6 that is encoded in the genome of human.


S26A6_HUMAN Solute carrier family 26 member 6 (sprot)

A solute carrier family 26 member 6 that is encoded in the genome of human.


S4A5_HUMAN Electrogenic sodium bicarbonate cotransporter 4 (sprot)

An electrogenic sodium bicarbonate cotransporter 4 that is encoded in the genome of human.


ANO3_HUMAN Anoctamin-3 (sprot)

An anoctamin-3 that is encoded in the genome of human.


GTR11_HUMAN Solute carrier family 2, facilitated glucose transporter member 11 (sprot)

A solute carrier family 2, facilitated glucose transporter member 11 that is encoded in the genome of human.


ABCA2_HUMAN ATP-binding cassette sub-family A member 2 (sprot)

An ATP-binding cassette sub-family A member 2 that is encoded in the genome of human.


S19A3_HUMAN Thiamine transporter 2 (sprot)

A thiamine transporter 2 that is encoded in the genome of human.


TTYH3_HUMAN Protein tweety homolog 3 (sprot)

A protein tweety homolog 3 that is encoded in the genome of human.


S39A8_HUMAN Metal cation symporter ZIP8 (sprot)

A metal cation symporter ZIP8 that is encoded in the genome of human.


TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 (sprot)

A transient receptor potential cation channel subfamily V member 6 that is encoded in the genome of human.


S26A1_HUMAN Sulfate anion transporter 1 (sprot)

A sulfate anion transporter 1 that is encoded in the genome of human.


S12A5_HUMAN Solute carrier family 12 member 5 (sprot)

A solute carrier family 12 member 5 that is encoded in the genome of human.


NPAL2_HUMAN NIPA-like protein 2 (sprot)

A NIPA-like protein 2 that is encoded in the genome of human.


S52A2_HUMAN Solute carrier family 52, riboflavin transporter, member 2 (sprot)

A solute carrier family 52, riboflavin transporter, member 2 that is encoded in the genome of human.


TRPV4_HUMAN Transient receptor potential cation channel subfamily V member 4 (sprot)

A transient receptor potential cation channel TRPV4 that is encoded in the genome of human.


FOH1B_HUMAN Putative N-acetylated-alpha-linked acidic dipeptidase (sprot)

A prostate-specific membrane antigen-like protein that is encoded in the genome of human.


NCKX3_HUMAN Sodium/potassium/calcium exchanger 3 (sprot)

A sodium/potassium/calcium exchanger 3 that is encoded in the genome of human.


ANO8_HUMAN Anoctamin-8 (sprot)

An anoctamin-8 that is encoded in the genome of human.


TRPM3_HUMAN Transient receptor potential cation channel subfamily M member 3 (sprot)

A transient receptor potential cation channel subfamily M member 3 that is encoded in the genome of human.


TRPC7_HUMAN Short transient receptor potential channel 7 (sprot)

A short transient receptor potential cation channel TRPC7 that is encoded in the genome of human.


S39A2_HUMAN Zinc transporter ZIP2 (sprot)

A zinc transporter ZIP2 that is encoded in the genome of human.


S52A3_HUMAN Solute carrier family 52, riboflavin transporter, member 3 (sprot)

A solute carrier family 52, riboflavin transporter, member 3 that is encoded in the genome of human.


PLCB1_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (sprot)

A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 that is encoded in the genome of human.


ANO2_HUMAN Anoctamin-2 (sprot)

An anoctamin-2 that is encoded in the genome of human.


TRPV5_HUMAN Transient receptor potential cation channel subfamily V member 5 (sprot)

A transient receptor potential cation channel subfamily V member 5 that is encoded in the genome of human.


DUOX2_HUMAN Dual oxidase 2 (sprot)

A dual oxidase 2 that is encoded in the genome of human.


DUOX1_HUMAN Dual oxidase 1 (sprot)

A dual oxidase 1 that is encoded in the genome of human.


SERC1_HUMAN Serine incorporator 1 (sprot)

A serine incorporator 1 that is encoded in the genome of human.


S22AB_HUMAN Solute carrier family 22 member 11 (sprot)

A solute carrier family 22 member 11 that is encoded in the genome of human.


S6A13_HUMAN Sodium- and chloride-dependent GABA transporter 2 (sprot)

A sodium- and chloride-dependent GABA transporter 2 that is encoded in the genome of human.


AT8A2_HUMAN Phospholipid-transporting ATPase IB (sprot)

A phospholipid-transporting ATPase IB that is encoded in the genome of human.


ANO10_HUMAN Anoctamin-10 (sprot)

An anoctamin-10 that is encoded in the genome of human.


S52A1_HUMAN Solute carrier family 52, riboflavin transporter, member 1 (sprot)

A solute carrier family 52, riboflavin transporter, member 1 that is encoded in the genome of human.


S39A1_HUMAN Zinc transporter ZIP1 (sprot)

A zinc transporter ZIP1 that is encoded in the genome of human.


SL2A8_HUMAN Solute carrier family 2, facilitated glucose transporter member 8 (sprot)

A solute carrier family 2, facilitated glucose transporter member 8 that is encoded in the genome of human.


SC5A4_HUMAN Probable glucose sensor protein SLC5A4 (sprot)

A probable glucose sensor protein SLC5A4 that is encoded in the genome of human.


SO1C1_HUMAN Solute carrier organic anion transporter family member 1C1 (sprot)

A solute carrier organic anion transporter family member 1C1 that is encoded in the genome of human.


TRPM5_HUMAN Transient receptor potential cation channel subfamily M member 5 (sprot)

A transient receptor potential cation channel subfamily M member 5 that is encoded in the genome of human.


AT10D_HUMAN Phospholipid-transporting ATPase VD (sprot)

A phospholipid-transporting ATPase VD that is encoded in the genome of human.


TRPC4_HUMAN Short transient receptor potential channel 4 (sprot)

A short transient receptor potential cation channel TRPC4 that is encoded in the genome of human.


SL9A2_HUMAN Sodium/hydrogen exchanger 2 (sprot)

A sodium/hydrogen exchanger 2 that is encoded in the genome of human.


S23A2_HUMAN Solute carrier family 23 member 2 (sprot)

A solute carrier family 23 member 2 that is encoded in the genome of human.


GTR6_HUMAN Solute carrier family 2, facilitated glucose transporter member 6 (sprot)

A solute carrier family 2, facilitated glucose transporter member 6 that is encoded in the genome of human.


S23A1_HUMAN Solute carrier family 23 member 1 (sprot)

A solute carrier family 23 member 1 that is encoded in the genome of human.


NCKX2_HUMAN Sodium/potassium/calcium exchanger 2 (sprot)

A sodium/potassium/calcium exchanger 2 that is encoded in the genome of human.


TRPC5_HUMAN Short transient receptor potential channel 5 (sprot)

A short transient receptor potential channel 5 that is encoded in the genome of human.


S12A4_HUMAN Solute carrier family 12 member 4 (sprot)

A solute carrier family 12 member 4 that is encoded in the genome of human.


NAC2_HUMAN Sodium/calcium exchanger 2 (sprot)

A sodium/calcium exchanger 2 that is encoded in the genome of human.


CLCA2_HUMAN Calcium-activated chloride channel regulator 2 (sprot)

A calcium-activated chloride channel regulator 2 that is encoded in the genome of human.


TRPC6_HUMAN Short transient receptor potential channel 6 (sprot)

A short transient receptor potential channel 6 that is encoded in the genome of human.


AT11B_HUMAN Phospholipid-transporting ATPase IF (sprot)

A phospholipid-transporting ATPase IF that is encoded in the genome of human.


S27A6_HUMAN Long-chain fatty acid transport protein 6 (sprot)

A long-chain fatty acid transport protein 6 that is encoded in the genome of human.


AT8A1_HUMAN Phospholipid-transporting ATPase IA (sprot)

A phospholipid-transporting ATPase IA that is encoded in the genome of human.


SC6A5_HUMAN Sodium- and chloride-dependent glycine transporter 2 (sprot)

A sodium- and chloride-dependent glycine transporter 2 that is encoded in the genome of human.


DGLA_HUMAN Diacylglycerol lipase-alpha (sprot)

A diacylglycerol lipase-alpha that is encoded in the genome of human.


LRP12_HUMAN Low-density lipoprotein receptor-related protein 12 (sprot)

A low-density lipoprotein receptor-related protein 12 that is encoded in the genome of human.


TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 (sprot)

A transient receptor potential cation channel TRPV2 that is encoded in the genome of human.


S12A7_HUMAN Solute carrier family 12 member 7 (sprot)

A solute carrier family 12 member 7 that is encoded in the genome of human.


S4A7_HUMAN Sodium bicarbonate cotransporter 3 (sprot)

A sodium bicarbonate cotransporter 3 that is encoded in the genome of human.


CLCA3_HUMAN Calcium-activated chloride channel regulator family member 3 (sprot)

A calcium-activated chloride channel regulator family member 3 that is encoded in the genome of human.


DGKB_HUMAN Diacylglycerol kinase beta (sprot)

A diacylglycerol kinase beta that is encoded in the genome of human.


optic choroid

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP].


endometrium luminal epithelium

A luminal layer of epithelium that is part of a endometrium epithelium.


submandibular gland primordium

A primordium that has the potential to develop into a submandibular gland.


ciliary basal body

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.


apical junction complex

A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.


cilium

A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.


centriole

A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.


basolateral part of cell

The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells.


cell periphery

The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.


basal plasma membrane

The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.


non-motile cilium

A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.


lateral plasma membrane

The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.


basal part of cell

The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.


stereocilium bundle

A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes.


intracellular estrogen receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


cell growth

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.


epithelial cilium movement involved in extracellular fluid movement

The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.


cilium assembly

The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.


microtubule binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to a microtubule, a filament composed of tubulin monomers.


melanosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.


cell-cell junction organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.


establishment of epithelial cell apical/basal polarity

The specification and formation of the apicobasal polarity of an epithelial cell.


water transport

The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


platelet-derived growth factor receptor signaling pathway

The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


response to estrogen

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.


muramyl dipeptide binding

Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan.


peroxisome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.


interleukin-4 production

The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


mitotic cytokinesis

A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.


detection of mechanical stimulus

The series of events by which a mechanical stimulus is received and converted into a molecular signal.


metaphase/anaphase transition of mitotic cell cycle

The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


apoptotic process involved in mammary gland involution

Any apoptotic process that triggers the activity of proteolytic caspases whose actions dismantle the mammary epithelial cells resulting in their programmed cell death.


intestinal absorption

Any process in which nutrients are taken up from the contents of the intestine.


vascular endothelial growth factor receptor signaling pathway

The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


prostatic bud formation

The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth.


apoptotic process involved in morphogenesis

Any apoptotic process that contributes to the shaping of an anatomical structure.


calcium-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+).


interleukin-5 production

The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


hormone-mediated apoptotic signaling pathway

The series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered.


epithelial cell apoptotic process involved in palatal shelf morphogenesis

An apoptotic process in a palatal shelf epithelial cell that contributes to the shaping of the palatal shelf.


mitochondrial membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.


cellular response to estrogen stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.


ATP-dependent activity

A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.


interleukin-13 production

The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


cellular component biogenesis

A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.


cellular component assembly

The aggregation, arrangement and bonding together of a cellular component.


T cell differentiation

The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.


mammary gland epithelial cell differentiation

The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland.


epithelial cell proliferation

The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.


mammary gland epithelial cell proliferation

The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.


epithelial cell differentiation involved in prostate gland development

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland.


ameboidal-type cell migration

Cell migration that is accomplished by extension and retraction of a pseudopodium.


epithelial cell proliferation involved in prostate gland development

The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time.


epithelial cell proliferation involved in salivary gland morphogenesis

The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland.


cell proliferation involved in metanephros development

The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros.


epithelial cell proliferation involved in mammary gland duct elongation

The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth.


intestinal epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine.


epithelial cell migration

The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.


epithelial cell maturation involved in prostate gland development

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.


secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate.


OSPC3_SHIFL Arginine ADP-riboxanase OspC3 (sprot)


OSPC1_SHIFL Arginine ADP-riboxanase OspC1 (sprot)


cell division

The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.


lens fiber cell development

The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


layer of retina

Any of the layers that make up the retina[MP].


retinoic acid receptor gamma isoform 2 (mouse)

A retinoic acid receptor gamma (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18911-2.


Wilms tumor protein homolog isoform 2 (mouse)

A Wilms tumor protein isoform 2 that is encoded in the genome of mouse.


roof of mouth development

The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.


GDF6_HUMAN Growth/differentiation factor 6 (sprot)

A growth/differentiation factor 6 that is encoded in the genome of human.


The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.


embryonic skeletal system morphogenesis

The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.


postcranial axial skeletal system

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.


regulation of canonical Wnt signaling pathway

Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


ectoplacental cone

Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta.


presumptive midbrain

A presumptive structure that has the potential to develop into a midbrain.


forelimb bud

A limb bud that develops into a forelimb.


female reproductive system

The organs and associated structures associated with bearing offspring in a female animal.


negative regulation of Wnt signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.


transmembrane receptor protein phosphatase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate.


sonic hedgehog protein N-product dually lipidated 1 (mouse)

A sonic hedgehog protein N-product in mouse that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314.


motile cilium

A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.


axoneme

The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.


protein localization to cilium

A process in which a protein is transported to, or maintained in, a location within a cilium.


CCD40_HUMAN Coiled-coil domain-containing protein 40 (sprot)

A coiled-coil domain-containing protein 40 that is encoded in the genome of human.


DRC4_HUMAN Dynein regulatory complex subunit 4 (sprot)

A dynein regulatory complex subunit 4 that is encoded in the genome of human.


CCD39_HUMAN Coiled-coil domain-containing protein 39 (sprot)

A coiled-coil domain-containing protein 39 that is encoded in the genome of human.


cilium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.


Golgi to plasma membrane protein transport

The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.


cilium movement

The directed, self-propelled movement of a cilium.


trans-Golgi network membrane

The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.


ciliated cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A cell that has a filiform extrusion of the cell surface.


cultured cell

A cell in vitro that is or has been maintained or propagated as part of a cell culture.


DRC3_HUMAN Dynein regulatory complex subunit 3 (sprot)

A dynein regulatory complex subunit 3 that is encoded in the genome of human.


ASAP1_HUMAN Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (sprot)

An Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 that is encoded in the genome of human.


RFIP3_HUMAN Rab11 family-interacting protein 3 (sprot)

A Rab11 family-interacting protein 3 that is encoded in the genome of human.


RB11A_HUMAN Ras-related protein Rab-11A (sprot)

A Ras-related protein Rab-11A that is encoded in the genome of human.


ARF4_HUMAN ADP-ribosylation factor 4 (sprot)

An ADP-ribosylation factor 4 that is encoded in the genome of human.


RAB8A_HUMAN Ras-related protein Rab-8A (sprot)

A Ras-related protein Rab-8A that is encoded in the genome of human.


positive regulation of cilium assembly

Any process that activates or increases the frequency, rate or extent of the formation of a cilium.


axonemal dynein complex

A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.


polycystin complex

A stable heterodimeric complex composed of polycystin-1 and polycystin-2.


SMO_MOUSE Protein smoothened (sprot)

A protein smoothened that is encoded in the genome of mouse.


sperm flagellum

A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.


9+2 motile cilium

A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).


photoreceptor cell cilium

A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment.


photoreceptor outer segment

The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.


flagellated sperm cell

A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion.


nephron tubule epithelial cell

An epithelial cell that is part of a nephron tubule.


9+0 motile cilium

A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme).


radial spoke head 1

The portion of the radial spoke 1 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme.


radial spoke head 3

The portion of the radial spoke 3 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme.


CFA61_HUMAN Cilia- and flagella-associated protein 61 (sprot)

A cilia- and flagella-associated protein 61 that is encoded in the genome of human.


cilia- and flagella-associated protein 61 isoform h4 (human)

A cilia- and flagella-associated protein 61 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NHU2-4.


cystin-1 isoform 1, N-terminal myristoylated form (mouse)

A cystin-1 isoform 1, N-terminal myristoylated form in mouse. UniProtKB:Q8R4T1-1, 2-145, Gly-2, MOD:00068.


stomach development

The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ.


fusion of sperm to egg plasma membrane involved in single fertilization

The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.


maintenance of protein localization in endoplasmic reticulum

Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum.


regulation of protein-containing complex assembly

Any process that modulates the frequency, rate or extent of protein complex assembly.


negative regulation of protein-containing complex assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.


pyruvate dehydrogenase complex

Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).


gamma-tubulin small complex

A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex.


TRAPPII protein complex

A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself.


SAGA complex

A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).


mitochondrial proton-transporting ATP synthase complex

A proton-transporting ATP synthase complex found in the mitochondrial membrane.


mitochondrial outer membrane translocase complex

A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments.


mitochondrial respiratory chain complex IV

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).


catenin complex

Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton.


clathrin coat

A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.


vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.


mitochondrial respirasome

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.


interferon regulatory factor 3 complex

An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3.


gamma-tubulin ring complex

A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe.


SLIK (SAGA-like) complex

A SAGA-type histone acetyltransferase complex that contains a smaller form of Spt7 (lacking the SPT8 binding region) than the fungal SAGA complex, and consequently lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction.


MICOS complex

Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60.


vacuolar proton-transporting V-type ATPase, V0 domain

The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.


CBF3 complex

A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p.


biolink:MacromolecularComplex biolink:BiologicalEntity biolink:NamedThing biolink:MacromolecularMachineMixin biolink:ThingWithTaxon


ciliary basal body organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum).


basal body patch

The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster.


cerebrospinal fluid circulation

The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional.


motile cilium assembly

The aggregation, arrangement and bonding together of a set of components to form a motile cilium.


axoneme assembly

The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.


choroid plexus epithelial cell

Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord.


glycolytic process through fructose-6-phosphate

The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.


positive regulation of glycolytic process

Any process that activates or increases the frequency, rate or extent of glycolysis.


negative regulation of glycolytic process through fructose-6-phosphate

Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate.


negative regulation of glycolytic process

Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.


beta-D-fructofuranose 2,6-bisphosphate

A D-fructofuranose 2,6-bisphosphate with a beta-configuration at the anomeric centre.


An organophosphate oxoanion that is the tetraanion of beta-D-fructofuranose 2,6-bisphosphate.


canonical glycolysis

The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.


citric acid

A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.


beta-D-fructofuranose 6-phosphate(2-)

An organophosphate oxoanion that is the dianion of beta-D-fructofuranose 6-phosphate arising from deprotonation of the phosphate OH groups.


A D-fructofuranose 1,6-bisphosphate(4-) that is the conjugate base of beta-D-fructofuranose 1,6-bisphosphate.


sperm principal piece

The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.


phosphofructokinase activity

Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule.


glycogen catabolic process

The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.


positive regulation of insulin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.


glycolysis from storage polysaccharide through glucose-1-phosphate

The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH.


protein localization to cytoskeleton

A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.


D-xylulose 5-phosphate(2-)

An organophosphate oxoanion that is the dianion of D-xylulose 5-phosphate arising from deprotonation of the phosphate OH groups; major species at pH 7.3.


cell body

The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.


acrosomal vesicle

A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.


outer acrosomal membrane

The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.


nuclear inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.


sperm midpiece

The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.


axonemal A tubule inner sheath

A structural network of microtubule inner proteins (MIPs) located inside the lumen of the A tubule of the axonemal microtubule doublet that helps stabilize the A tubule.


axonemal B tubule inner sheath

A structural network of microtubule inner proteins (MIPs) located inside the lumen of the B tubule of the axonemal microtubule doublet that helps stabilize the B tubule.


sperm fibrous sheath

A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat.


acrosomal membrane

The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.


acrosomal matrix

A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction.


sperm mitochondrial sheath

The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.


axonemal central apparatus

Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules.


sperm cytoplasmic droplet

A small amount of cytoplasm surrounded by a cell membrane that is generally retained in spermatozoa after spermiogenesis, when the majority of the cytoplasm is phagocytosed by Sertoli cells to produce what are called residual bodies. Initially, the droplet is located at the neck just behind the head of an elongated spermatid. During epididymal transit, the cytoplasmic droplet migrates caudally to the annulus at the end of the midpiece; the exact position and time varies by species. The cytoplasmic droplet consists of lipids, lipoproteins, RNAs, a variety of hydrolytic enzymes, receptors, ion channels, and Golgi-derived vesicles. The droplet may be involved in regulatory volume loss (RVD) at ejaculation, and in most species, though not in humans, the cytoplasmic droplet is lost at ejaculation. Note that the cytoplasmic droplet is distinct from 'excessive residual cytoplasm' that sometimes remains in epididymal spermatozoa, particularly when spermiogenesis has been disrupted.


inner acrosomal membrane

The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.


glycocalyx

A carbohydrate rich layer at the outermost periphery of a cell.


protein disulfide isomerase activity

Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.


inner dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


protein polyglutamylation

The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid.


flagellated sperm motility

The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.


glycolytic process

The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.


calcium channel regulator activity

Modulates the activity of a calcium channel.


cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.


establishment of protein localization

The directed movement of a protein to a specific location.


regulation of cilium beat frequency involved in ciliary motility

Any process that modulates the frequency of cilium beating involved in ciliary motility.


nuclear envelope organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.


beta-N-acetylhexosaminidase activity

Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.


spermatid development

The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.


acrosome reaction

The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.


store-operated calcium entry

A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.


sperm axoneme assembly

The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.


acrosome assembly

The formation of the acrosome from the spermatid Golgi.


P-type sodium:potassium-exchanging transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).


unidimensional cell growth

The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell.


potassium ion transport

The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


sperm capacitation

A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.


nitric oxide mediated signal transduction

An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.


regulation of acrosome reaction

Any process that modulates the frequency, rate or extent of the acrosome reaction.


regulation of calcium ion transport

Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cilium movement involved in cell motility

Movement of cilia mediated by motor proteins that contributes to the movement of a cell.


spermatid nucleus differentiation

The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.


sperm mitochondrion organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm.


peptidyl-tyrosine sulfation

The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine.


Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.


cell motility in response to calcium ion

Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus.


microtubule sliding

The movement of one microtubule along another microtubule.


acrosomal vesicle exocytosis

The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction.


antibacterial humoral response

An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.


glycolytic process through glucose-6-phosphate

The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP.


establishment of mitochondrion localization

The directed movement of the mitochondrion to a specific location.


cellular anatomical entity morphogenesis

The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system.


spermatid differentiation

The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


calcineurin complex

A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.


dynein axonemal heavy chain 8 isoform 1 (mouse)

A dynein axonemal heavy chain 8 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91XQ0-1.


acrosin-binding protein isoform m1 cleaved 1 (mouse)

An acrosin-binding protein isoform m1 (mouse) that has been processed by proteolytic cleavage. UniProtKB:Q3V140-1, 273-540.


gluconeogenesis

The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.


The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis.


malate transmembrane transporter activity

Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out).


pyruvate carboxylase activity

Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate.


acidic amino acid transmembrane transporter activity

Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3.


pyruvate transmembrane transporter activity

Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other.


dicarboxylic acid transmembrane transporter activity

Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups.


alpha-ketoglutarate transmembrane transporter activity

Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle.


glucose 6-phosphate:inorganic phosphate antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out).


glucose-6-phosphatase activity

Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate.


phosphonatoenolpyruvate

An organophosphate oxoanion obtained by deprotonation of the carboxy and phosphate groups of phosphoenolpyruvic acid.


An organophosphate oxoanion arising from deprotonation of the phosphate OH and carboxy groups of 2-phospho-D-glyceric acid; major species at pH 7.3.


MDHM_HUMAN Malate dehydrogenase, mitochondrial (sprot)

A malate dehydrogenase, mitochondrial that is encoded in the genome of human.


DIC_HUMAN Mitochondrial dicarboxylate carrier (sprot)

A mitochondrial dicarboxylate carrier that is encoded in the genome of human.


PYC_HUMAN Pyruvate carboxylase, mitochondrial (sprot)

A pyruvate carboxylase, mitochondrial that is encoded in the genome of human.


ODC_HUMAN Mitochondrial 2-oxodicarboxylate carrier (sprot)

A mitochondrial 2-oxodicarboxylate carrier that is encoded in the genome of human.


PCKGM_HUMAN Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (sprot)

A phosphoenolpyruvate carboxykinase [GTP], mitochondrial that is encoded in the genome of human.


positive regulation of insulin secretion involved in cellular response to glucose stimulus

Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.


ATP

An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways.


D-glyceraldehyde 3-phosphate(2-)

Dianion of D-glyceraldehyde 3-phosphate arising from deprotonation of both OH groups of the phosphate.


alpha-D-glucose 6-phosphate(2-)

A D-glucopyranose 6-phosphate(2-) obtaned by deprotonation of the phosphate OH groups of alpha-D-glucose 6-phosphate; major species at pH 7.3.


alpha-D-glucose

D-Glucopyranose having alpha-configuration at the anomeric centre.


3',5'-cyclic AMP(1-)

An organophosphate oxoanion that is the conjugate base of 3',5'-cyclic AMP arising from deprotonation of the free phosphate OH group; major species at pH 7.3.


pyruvate

A 2-oxo monocarboxylic acid anion that is the conjugate base of pyruvic acid, arising from deprotonation of the carboxy group.


An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.


Dianion of NADH arising from deprotonation of the two diphosphate OH groups; major species at pH 7.3.


3-phosphonato-D-glyceroyl phosphate(4-)

Tetraanion of 3-phospho-D-glyceroyl dihydrogen phosphate arising from deprotonation of both phosphate groups.


An organophosphate oxoanion arising from deprotonation of the carboxy and phosphate OH groups of 3-phospho-D-glyceric acid; major species at pH 7.3.


hexokinase activity

Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.