Progesterone Receptor Positive by Immunohistochemistry 11-20 Percent

An immunohistochemical staining finding indicating that 11-20 percent of the cells in a tissue sample are expressing progesterone receptor.


Refractory Hairy Cell Leukemia Variant

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Hairy cell leukemia variant that is resistant to treatment.


HHV-8-Associated Multicentric Castleman Disease

Multicentric Castleman disease associated with HHV8 infection.


Sellar Chondroid Chordoma

A chondroid chordoma that arises from the sellar region.


Conventional Chordoma

A malignant bone tumor arising from the remnants of the fetal notochord. It is characterized by the presence of large epithelioid cells with clear to light eosinophilic cytoplasm. Some of the cells are large with bubbly, vacuolated cytoplasm (physaliphorous cells). The cells form cords and nests that are embedded within an extracellular myxoid matrix.


Grade 1 Abducens Nerve Disorder, CTCAE

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Asymptomatic; clinical or diagnostic observations only; intervention not indicated


An adenocarcinoma that arises from the sinonasal tract. It is characterized by the absence of features that resemble intestinal adenocarcinoma.


Recurrent Malignant Mastocytosis

The reemergence of malignant mastocytosis after a period of remission.


Recurrent Mast Cell Leukemia

The reemergence of mast cell leukemia after a period of remission.


Psychogenic Musculoskeletal Chest Pain with Dysfunctional Breathing

A condition in which there is musculoskeletal chest pain associated with inappropriate hyperpnea or tachypnea. (ACC/AHA)


Psychogenic Musculoskeletal Chest Pain

A condition in which there is the sensation of musculoskeletal chest pain due to a conversion disorder. (ACC/AHA)


Sellar Gangliocytoma

A tumor that arises in the sellar region and is characterized by the presence of mature ganglion cells and neuronal differentiation. It is often associated with the presence of pituitary neuroendocrine tumors/adenomas.


Double-Negative Prostate Carcinoma

A metastatic, castration-resistant prostate carcinoma that is composed of fibroblast growth factor-driven malignant cells.


Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents

Castration-resistant prostate carcinoma which is refractory to second-generation androgen receptor axis-targeted agents, namely abiraterone and enzalutamide.


Intermediate Atypical Prostate Carcinoma

An aggressive, castration-resistant, histologically distinct, metastatic carcinoma arising from the prostate gland. It is characterized by the presence of a pure population of cytologically bland malignant epithelial cells with moderate to abundant cytoplasm and rare mitotic figures. The prognosis is poor.


Aggressive Variant Prostate Carcinoma

A lethal form of advanced castration-resistant prostate carcinoma that emerges in the later stages of castration-resistant treatment. It is an adaptive response to androgen receptor pathway inhibition. The morphologic features vary, ranging from poorly differentiated carcinomas to mixed adenocarcinoma-small cell carcinomas to pure small cell carcinomas expressing neuroendocrine markers. Clinically, it manifests with rapidly progressive disease, visceral or lytic bone metastases and bulky tumor masses. Molecular studies have shown the loss of tumor suppressor genes TP53 and RB1.


Grade 4 Pericardial Effusion, CTCAE

Life-threatening consequences; urgent intervention indicated


Advanced Unfavorable Hodgkin Lymphoma

An advanced Hodgkin lymphoma with unfavorable prognosis.


allylamine antifungal drug

An organonitrogen compound that contains an amino group that is attached to a carbon which is itself attached to an olefinic carbon and which has been used as an antifungal drug.


Situs inversus thoracis

A congenital condition in which there is complete right-to-left reversal of the position of the thoracic organs.


Urethritis Glandularis

A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by metaplastic glandular cells.


magnesium oxide nanocrystal

A nanocrystal composed of magnesium oxide.


Dialysis Catheter Tunnel Infection

Local infection involving the subcutaneously tunneled portion of a dialysis catheter.


Grade 4 Stevens-Johnson Syndrome, CTCAE

Skin sloughing covering 10-30% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment)


Grade 4 Gastrointestinal Stoma Hemorrhage, CTCAE


Lugano Classification Stage IV Adult Hodgkin Lymphoma AJCC v8

Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the CSF, bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


Lugano Classification Stage IV Adult Lymphoma AJCC v8


Grade 2 Musculoskeletal Deformity, CTCAE

Deformity, hypoplasia, or asymmetry able to be remediated by prosthesis (e.g., shoe insert) or covered by clothing


Pelvic Infection, CTCAE

A disorder characterized by an infectious process involving the pelvic cavity.


Grade 3 Pelvic Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Pelvic Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 5 Pelvic Infection, CTCAE

Death


Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Grade 3 Middle Ear Intra-Operative Injury, CTCAE


Astrocytoma, Not Otherwise Specified

A central nervous system tumor with morphological features of astrocytoma in which there is insufficient information on the IDH genes status.


Grade 3 Superficial Soft Tissue Fibrosis, CTCAE

Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL


Grade 1 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Ciliary Body Benign Teratoid Medulloepithelioma

A rare, unilateral, benign embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium and contains heterologous elements, particularly cartilage, skeletal muscle, and brain tissue.


Recurrent Extragonadal Seminoma

The reemergence of extragonadal seminoma after a period of remission.


Recurrent Malignant Extragonadal Germ Cell Tumor

The reemergence of malignant extragonadal germ cell tumor after a period of remission.


Recurrent Malignant Extragonadal Nongerminomatous Germ Cell Tumor

The reemergence of a malignant extragonadal nongerminomatous germ cell tumor after a period of remission.


Stage IA Cervical Cancer FIGO 2018

Invasive cervical carcinoma that can be diagnosed only by microscopy, with maximum depth of invasion less than 5 mm. (FIGO 2018)


Stage IA2 Cervical Cancer FIGO 2018

Cervical carcinoma with measured stromal invasion equal or more than 3 mm and less than 5 mm in depth. (FIGO 2018)


Stage IA1 Cervical Cancer FIGO 2018

Cervical carcinoma with measured stromal invasion less than 3 mm in depth. (FIGO 2018)


quinoxaline

A naphthyridine in which the nitrogens are at positions 1 and 4.


Grade 3 Vagina Stricture or Stenosis, CTCAE


Stage I Pancreatic Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor limited to the pancreas and measuring less than 2 cm. N0: No regional lymph node involvement. M0: No distant metastasis. (AJCC 8th ed.)


Infiltrating Intramuscular Lipoma

An infiltrating lipoma that affects skeletal muscle.  It has a higher rate of local recurrence.


Refractory Endometrial Dedifferentiated Carcinoma

Endometrial dedifferentiated carcinoma that is resistant to treatment.


Campylobacter jejuni infection

An infection that is caused by Campylobacter jejuni.


Small Intestinal Infection

An infectious process affecting the small intestine.


Duodenal Infection

An infectious process affecting the duodenum.


Stage IVB Rectal Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis.  (AJCC 8th ed.)


Cervical Mucinous Adenocarcinoma, Not Otherwise Specified

A cervical mucinous adenocarcinoma in which more than 50% of malignant cells contain intracytoplasmic mucin. There is no evidence of gastric, intestinal, or signet ring cell differentiation.


Localized PRETEX IV Hepatoblastoma

PRETEX IV hepatoblastoma confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


glycerolipid

Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.


triradylglycerol

A glycerol compound having one of three possible substituent groups - either acyl, alkyl, or alk-1-enyl - at each of the three possible positions sn-1, sn-2 or sn-3. has functional parent glycerol (CHEBI:17754), children: triglyceride (CHEBI:17855). Parent: is_a glycerolipid (CHEBI:35741)


glyceride

Any ester resulting from the condensation of one or more of the hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl substituents at positions 1 and 2 are specified as gamma-linolenoyl and oleoyl respectively.


An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.


glycerophospholipid

Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.


triglyceride

Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


Hepatitis Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis virus exposure and injury of the liver parenchyma.


Stage IIIA Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage IIIA includes: T3a, N0, M0. T3a: Multiple tumors more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Epithelioid hemangioendothelioma of liver

A low-grade malignant blood vessel neoplasm that arises from the liver.  It is characterized by the presence of epithelioid endothelial cells.  The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma.  Patients may be asymptomatic or present with an abdominal mass, ascites, and jaundice.


Stage I Intrahepatic Bile Duct Cancer AJCC v8

Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0). T1a: Solitary tumor equal to or less than 5 cm without vascular invasion.  T1b: Solitary tumor larger than 5 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Unresectable Fibrolamellar Carcinoma

A fibrolamellar carcinoma that is not amenable to surgical resection.


Hepatoblastoma with Pure Fetal Epithelial Differentiation

A hepatoblastoma composed of small cells resembling the fetal hepatocytes, forming thin trabeculae.


Recurrent Adult Hepatocellular Carcinoma

A hepatocellular carcinoma that occurs during adulthood and has recurred after a period of remission.


Locally Advanced Hepatocellular Carcinoma

Hepatocellular carcinoma that has spread to nearby tissues or lymph nodes.


Hepatoblastoma recurrent

The reemergence of hepatoblastoma after a period of remission.


Stage IV Childhood Hepatocellular Carcinoma AJCC v7

Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


BCLC Stage 0 Hepatocellular Carcinoma

Very early hepatocellular carcinoma. Patients are optimal candidates for resection. (HPB (Oxford) 2005; 7(1):35-41)


BCLC Stage D Hepatocellular Carcinoma

End-stage hepatocellular carcinoma.  Patients will receive symptomatic treatment. (HPB (Oxford) 2005; 7(1):35-41)


Localized PRETEX III Hepatoblastoma

PRETEX III hepatoblastoma confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Adult Liver Carcinoma

A hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood.


Stage IV Liver Cancer

Stage IV carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Metastatic Fibrolamellar Carcinoma

A fibrolamellar carcinoma that has spread from the liver to another anatomic site.


Stage III Hepatocellular Carcinoma AJCC v7

Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVA Hepatocellular Carcinoma AJCC v7

Stage IVA includes: Any T, N1, M0.  N1: Regional lymph node metastasis. M0: No distant metastasis.  (AJCC 7th ed.)


PRETEXT IV Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves all 4 quadrants; there is no quadrant free of tumor. (from PDQ 2004)


Non-Resectable Malignant Liver Neoplasm

A malignant liver neoplasm that is not amenable to surgical resection.


Adult Pleomorphic Hepatocellular Carcinoma

A pleomorphic hepatocellular carcinoma that occurs during adulthood.


Childhood Hepatoblastoma by Toronto Guidelines v2 Stage, Tier 2

A term that refers to the staging of childhood hepatoblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2. It includes localized tumors, metastatic tumors, and the PRETEXT system. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IV Hepatocellular Carcinoma AJCC v7


BCLC Stage C Adult Hepatocellular Carcinoma

Advanced hepatocellular carcinoma.  Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41)


Stage IV Hepatocellular Carcinoma AJCC v6

Stage IV includes (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.)


Extrarenal Rhabdoid Tumor of the Liver

A rare, aggressive primary malignant tumor of the liver that occurs in childhood.  It is characterized by the presence of a diffuse infiltrate of undifferentiated cells with rhabdoid features.


Adult Liver Embryonal Sarcoma

An embryonal sarcoma of the liver that occurs during adulthood.


Stage II Liver Cancer

Stage II carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Postsurgical Stage III Hepatoblastoma

No distant metastases, tumor unresectable or resected with gross residual tumor, or positive lymph nodes. (from PDQ 2004)


PRETEXT III Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 3 adjoining quadrants or 2 nonadjoining quadrants; 1 quadrant or 2 nonadjoining quadrants are free of tumor. (from PDQ 2004)


Refractory Hepatoblastoma

Hepatoblastoma that does not respond to treatment.


Uveal Melanoma Metastatic in the Liver

A melanoma that originates from melanocytes of the uveal tract and has spread to the liver.


Stage II Hepatocellular Carcinoma AJCC v8

Stage II includes: T2, N0, M0. T2: Solitary tumor larger than 2 cm with vascular invasion, or multiple tumors, none larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Liver Small Cell Neuroendocrine Carcinoma

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver. It is characterized by the presence of malignant small cells.


Stage IV Intrahepatic Bile Duct Cancer AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Stage IIIA Hepatocellular Carcinoma AJCC v7

Stage IIIA includes: T3a, N0, M0.  T3a: Multiple tumors more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Liver Cancer

Stage III carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Epithelial Hepatoblastoma with Pleomorphic Pattern

Epithelial hepatoblastoma characterized by the presence of fetal or embryonal cells showing nuclear pleomorphism. Malignant giant cells may be present.


Stage IIIC Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage IIIC includes: T4, N0, M0.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage I Hepatocellular Carcinoma AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Solitary tumor without vascular invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Colon Carcinoma Metastatic in the Liver

A carcinoma that originates from the colonic wall and has spread to the liver.


Stage III Hepatocellular Carcinoma AJCC v8

Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0). T3: Multiple tumors, at least one of which is larger than 5 cm. T4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Non-Teratoid Hepatoblastoma

A mixed epithelial and mesenchymal hepatoblastoma characterized by the absence of heterologous elements, muscle, cartilage or osteoid.


Stage IIIA Intrahepatic Bile Duct Cancer AJCC v8

Stage IIIA includes: T3, N0, M0. T3: Tumor perforating the visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Liver Mixed Adenoneuroendocrine Carcinoma

A carcinoma that arises from the liver and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Moderately Differentiated Hepatocellular Carcinoma

A hepatocellular carcinoma characterized by the presence of malignant cells with abundant eosinophilic cytoplasm forming trabecular and pseudoglandular patterns.  It is usually associated with tumors that are larger than 3 cm in diameter.


Hepatocellular carcinoma, spindle cell variant

A morphologic variant of hepatocellular carcinoma characterized by the presence of malignant spindle cells or atypical giant cells.


carcinosarcoma of liver

An aggressive carcinoma with a sarcomatous component that arises from the liver.  The sarcomatous component is clonally related to the more differentiated, carcinomatous component.  The prognosis is usually poor.


Hepatic cancer stage IVA

Stage IVA carcinoma of the liver according to the American Joint Committee on Cancer, 7th and 8th editions.


Stage II Intrahepatic Bile Duct Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Solitary tumor with intrahepatic vascular invasion, or multiple tumors, with or without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Hepatocellular Malignant Neoplasm, Not Otherwise Specified

A rare childhood malignant liver neoplasm with overlapping features of hepatoblastoma and hepatocellular carcinoma.


Stage I Childhood Hepatocellular Carcinoma AJCC v6 and v7


Locally Advanced Liver Carcinoma

Liver carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Teratoid Hepatoblastoma

A mixed epithelial and mesenchymal hepatoblastoma characterized by the presence of heterologous elements. The latter include neuroectoderm, endoderm, or melanin-holding cells. Muscle, cartilage and osteoid may or may not be present.


BCLC Stage B Hepatocellular Carcinoma

Intermediate hepatocellular carcinoma.  Patients may benefit from chemoembolization. (HPB (Oxford) 2005; 7(1):35-41)


Kaposi's sarcoma of liver

A Kaposi sarcoma that arises from the liver.


Stage IA Intrahepatic Bile Duct Cancer AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Solitary tumor equal to or less than 5 cm without vascular invasion.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Hepatocellular carcinoma characterized by the presence of diffuse neutrophil infiltrates within the tumor.


Stage IIIB Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage IIIB includes: T3b, N0, M0. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Childhood Hepatoblastoma by Toronto Guidelines v2 Stage

A term that refers to the staging of childhood hepatoblastoma according to the Toronto childhood cancer staging guidelines v2.


Stage 0 Intrahepatic Bile Duct Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ (intraductal tumor). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic hepatocellular carcinoma

A hepatocellular carcinoma that has spread to another anatomic site.


Unresectable Liver and Intrahepatic Bile Duct Carcinoma

Liver and intrahepatic bile duct carcinoma that is not amenable to surgical resection.


Childhood Liver Embryonal Sarcoma

An embryonal sarcoma of the liver that occurs during childhood.


Recurrent Childhood Hepatocellular Carcinoma

A hepatocellular carcinoma that occurs during childhood and has recurred after a period of remission.


Malignant Liver Non-Epithelial Neoplasm

A primary or metastatic malignant non-epithelial neoplasm that affects the liver.


BCLC Stage B Adult Hepatocellular Carcinoma


Hepatocellular Carcinoma by AJCC v8 Stage

A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to hepatocellular carcinomas and fibrolamellar carcinomas (fibrolamellar variant of hepatocellular carcinoma). Intrahepatic cholangiocarcinomas, combined hepatocellular-cholangiocarcinomas, and sarcomas of the liver are not staged using this staging system. (from AJCC 8th Ed.)


A hepatocellular carcinoma that arises in a patient with a history of organ transplantation.


Hepatitis B Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis B virus exposure and injury of the liver parenchyma.


Hepatitis C Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis C virus exposure and injury of the liver parenchyma.


BCLC Stage 0 Adult Hepatocellular Carcinoma

Very early hepatocellular carcinoma. Patients are optimal candidates for resection. (HPB (Oxford) 2005; 7(1):35-41)


Localized Non-Resectable Adult Liver Carcinoma

A localized hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and it is not amenable to surgical resection.


Recurrent Childhood Liver Cancer

A malignant neoplasm of the liver that occurs during childhood and has recurred after a period of remission.


Liver Yolk Sac Tumor

A yolk sac tumor that arises from the liver.


Stage I Liver Carcinoma

Stage I carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Colorectal Adenocarcinoma Metastatic in the Liver

An adenocarcinoma that originates from the colorectal area and has spread to the liver.


Stage IV Hepatocellular Carcinoma AJCC v8

Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Postsurgical Stage IV Hepatoblastoma

Distant metastases, regardless of the extent of liver involvement. (from PDQ 2004)


Localized Childhood Hepatoblastoma by Toronto Guidelines v2, Tier1

Tumor confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Small Cell Undifferentiated Hepatoblastoma

A hepatoblastoma composed exclusively of noncohesive sheets of small undifferentiated cells. Cases showing loss of INI1 nuclear staining should be classified as rhabdoid tumors.


Metastatic Childhood Hepatoblastoma by Toronto Guidelines v2, Tier 2

Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Postsurgical Stage I Hepatoblastoma

No metastases, tumor completely resected. (from PDQ 2004)


Well Differentiated Hepatocellular Carcinoma

A hepatocellular carcinoma characterized by the presence of malignant cells with mild atypia and an increased nuclear/cytoplasmic ratio forming thin trabecular patterns.  It is usually associated with small tumors and an early stage.


Stage IB Intrahepatic Bile Duct Cancer AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Solitary tumor larger than 5 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Childhood Fibrolamellar Carcinoma

A fibrolamellar variant of hepatocellular carcinoma that occurs during childhood.


Stage IVA Hepatocellular Carcinoma AJCC v8

Stage IVA includes: Any T, N1, M0. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


BCLC Stage A Adult Hepatocellular Carcinoma

Early hepatocellular carcinoma.  Patients are candidates for radical therapies (resection, liver transplantation, or percutaneous treatments). (HPB (Oxford) 2005; 7(1):35-41)


Metastatic Hepatoblastoma

Hepatoblastoma that has spread from its original site of growth to another anatomic site.


Childhood Hepatoblastoma by Toronto Guidelines v2 Stage, Tier 1

A term that refers to the staging of childhood hepatoblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Stage II Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage II includes: T2, N0, M0. T2: Solitary tumor with vascular invasion or multiple tumors none more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis.  For intrahepatic cholangiocarcinoma: Stage II includes: T2, N0, M0. T2: Solitary tumor with vascular invasion or multiple tumors, with or without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 7th Ed.)


Stage III Childhood Hepatocellular Carcinoma AJCC v7

Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Hepatoblastoma by PRETEXT Stage

A term that refers to the staging of hepatoblastoma, following the rules of the PRETEXT (pre-treatment extent of tumor) system.


Localized PRETEX I Hepatoblastoma

PRETEX I hepatoblastoma confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Hepatoblastoma resectable

Hepatoblastoma amenable to surgical removal.


Stage IVB Hepatocellular Carcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Hepatocellular Carcinoma by AJCC v7 Stage

A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 7th edition.


Stage IIIB Hepatocellular Carcinoma AJCC v8

Stage IIIB includes: T4, N0, M0. T4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Localized Unresectable Adult Hepatocellular Carcinoma

A localized hepatocellular carcinoma that occurs during adulthood and it is not amenable to surgical resection.


Adult Fibrolamellar Carcinoma

Fibrolamellar variant of hepatocellular carcinoma that occurs during adulthood.


Poorly Differentiated Hepatocellular Carcinoma

A hepatocellular carcinoma characterized by the presence of malignant pleomorphic cells forming solid patterns.


Recurrent Fibrolamellar Carcinoma

The reemergence of fibrolamellar carcinoma after a period of remission.


undifferentiated carcinoma of liver

A rare carcinoma that arises from the liver.  The diagnosis is made by immunohistochemical studies.  Morphologic studies alone cannot establish the diagnosis of carcinoma or further subclassify the malignant tumor.


A hepatocellular carcinoma that develops following alcohol-induced injury of the liver parenchyma.


Stage IVB Hepatocellular Carcinoma AJCC v7

Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


BCLC Stage C Hepatocellular Carcinoma

Advanced hepatocellular carcinoma.  Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41)


Stage I Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage I includes: T1, N0, M0. T1: Solitary tumor without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis.  For intrahepatic cholangiocarcinoma: Stage I includes: T1, N0, M0. T1: Solitary tumor without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 7th Ed.)


Small Hepatocellular Carcinoma

Hepatocellular carcinoma measuring equal to or less than 2 cm in diameter. It includes early hepatocellular carcinoma and small progressed hepatocellular carcinoma.


Hepatoblastoma by Postsurgical Stage

A term that refers to the staging of hepatoblastoma according to post-operative findings.


Pleomorphic Hepatocellular Carcinoma

A morphologic variant of hepatocellular carcinoma, characterized by the presence of malignant cells which show marked variation in their size and shape. Bizarre mononuclear or multinucleated giant cells are often present.


Stage IIIB Hepatocellular Carcinoma AJCC v7

Stage IIIB includes: T3b, N0, M0. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein. T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis.  For intrahepatic cholangiocarcinoma: Stage III includes: T3, N0, M0. T3: Tumor perforating the visceral peritoneum or involving the local extra hepatic structures by direct invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 7th Ed.)


large cell neuroendocrine carcinoma of liver

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver. It is characterized by the presence of malignant large cells.


PRETEXT I Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves only 1 quadrant; 3 adjoining liver quadrants are free of tumor. (from PDQ 2004)


Hepatocellular Carcinoma by AJCC v6 Stage

A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 6th edition.


Childhood Liver Angiosarcoma

An angiosarcoma that arises from the liver during childhood. Most cases arise within preexisting liver infantile hemangiomas.


Epithelial Hepatoblastoma

A subtype of hepatoblastoma characterized by the presence of an epithelial component and absence of mesenchymal elements. It includes hepatoblastoma with pure fetal epithelial differentiation, hepatoblastoma with combined fetal and embryonal epithelial differentiation, macrotrabecular hepatoblastoma, and small cell undifferentiated hepatoblastoma (small cell undifferentiated hepatoblastoma with loss of INI1 nuclear staining should be classified as rhabdoid tumor).


Hepatocellular Carcinoma by BCLC Stage

A staging classification system for hepatocellular carcinoma that uses variables related to tumor stage, liver functional status, physical status, and cancer-related symptoms, and links the stages with a treatment algorithm. (HPB (Oxford) 2005; 7(1):35-41)


Metastatic Childhood Hepatoblastoma by Toronto Guidelines v2, Tier 1

Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Hepatoblastoma non-resectable

Hepatoblastoma not amenable to surgical removal.


Intrahepatic Bile Duct Cancer by AJCC v8 Stage

A term that refers to the staging of intrahepatic bile duct cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to intrahepatic cholangiocarcinomas, combined hepatocellular-cholangiocarcinomas (mixed hepatocholangiocarcinomas), and primary neuroendocrine tumors of the liver. Primary sarcomas of the liver, pure hepatocellular carcinomas, hilar cholangiocarcinomas, and gallbladder carcinomas are not staged using this staging system. (from AJCC 8th Ed.)


Stage III Intrahepatic Bile Duct Cancer AJCC v8

Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0); (Any T, N1, M0). T3: Tumor perforating the visceral peritoneum. T4: Tumor involving local extrahepatic structures by direct invasion. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Chromophobe Hepatocellular Carcinoma

Hepatocellular carcinoma characterized by the presence of malignant cells with smooth chromophobic cytoplasm, abrupt focal nuclear anaplasia, and scattered microscopic pseudocysts.


Recurrent Hepatocellular Carcinoma

The reemergence of hepatocellular carcinoma after a period of remission


BCLC Stage A Hepatocellular Carcinoma

Early hepatocellular carcinoma.  Patients are candidates for radical therapies (resection, liver transplantation, or percutaneous treatments). (HPB (Oxford) 2005; 7(1):35-41)


Refractory Liver Carcinoma

Liver carcinoma that is resistant to treatment.


Stage IVB Liver Cancer

Stage IVB carcinoma of the liver according to the American Joint Committee on Cancer, 7th and 8th editions.


Metastatic PRETEX III Hepatoblastoma

PRETEX III hepatoblastoma with distant metastases. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Refractory Hepatocellular Carcinoma

Hepatocellular carcinoma that is resistant to treatment.


Localized PRETEX II Hepatoblastoma

PRETEX II hepatoblastoma confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Metastatic carcinoma to liver

A carcinoma that has spread to the liver from another primary anatomic site.  Representative examples include metastatic carcinomas from the colon, breast, and lung.


Localized Childhood Hepatoblastoma by Toronto Guidelines v2, Tier 2

Tumor confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Early Hepatocellular Carcinoma

A low grade, well differentiated small hepatocellular carcinoma. It lacks obvious stromal invasion and significant atypia.


Metastatic PRETEX IV Hepatoblastoma

PRETEX IV hepatoblastoma with distant metastases. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Liver Plasmacytoma

A plasmacytoma that arises in the liver.


Stage II Hepatocellular Carcinoma AJCC v6 and v7

Stage II includes: T2, N0, M0.  T2: Solitary tumor with vascular invasion or multiple tumors none more than 5 cm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


A rare type of hepatocellular carcinoma characterized by the presence of pleomorphic malignant cells that are intermixed with lymphocytes.


Stage III Hepatocellular Carcinoma AJCC v6

Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0); IIIC: (Any T, Any N, M0).  IIIA: T3: Multiple tumors more than 5 cm or tumor involving a major branch of the portal or hepatic vein(s).  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


PRETEXT II Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 2 adjoining quadrants; 2 adjoining quadrants are free of tumor. (from PDQ 2004)


Stage IV Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis.  For intrahepatic cholangiocarcinoma: Stage IVA includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor with periductal invasion. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis.  Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 7th Ed.)


Unresectable Hepatocellular Carcinoma

A hepatocellular carcinoma that is not amenable to surgical resection.


Hepatoblastoma with Combined Fetal and Embryonal Epithelial Differentiation

A hepatoblastoma composed of cells resembling fetal epithelial cells and small round cells resembling blastema cells.


Rectal Carcinoma Metastatic in the Liver

A carcinoma that originates from the rectum and has spread to the liver.


Adult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

A combined hepatocellular carcinoma and cholangiocarcinoma that occurs during adulthood.


Stage IIIA Hepatocellular Carcinoma AJCC v8

Stage IIIA includes: T3, N0, M0. T3: Multiple tumors, at least one of which is larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIC Hepatocellular Carcinoma AJCC v7

Stage IIIC includes: T4, N0, M0.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Childhood Malignant Liver Neoplasm

A malignant neoplasm that affects the liver and occurs during childhood.


BCLC Stage D Adult Hepatocellular Carcinoma

End-stage hepatocellular carcinoma.  Patients will receive symptomatic treatment. (HPB (Oxford) 2005; 7(1):35-41)


Macrotrabecular Massive Hepatocellular Carcinoma

Hepatocellular carcinoma characterized by more than 50% growth of macrotrabecular pattern (equal to or more than 6 to 10 cells thick). It presents with higher grade and stage compared to conventional hepatocellular carcinoma. It has poor prognosis with early recurrence and poor overall survival.


Stage II Childhood Hepatocellular Carcinoma AJCC v6 and v7


Metastatic PRETEX II Hepatoblastoma

PRETEX II hepatoblastoma with distant metastases. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIIB Intrahepatic Bile Duct Cancer AJCC v8

Stage IIIB includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor involving local extrahepatic structures by direct invasion. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Hepatocellular carcinoma characterized by the presence of steatohepatitis features, including macrovesicular steatosis, fibrosis, ballooning of malignant hepatocytes, Mallory bodies, and inflammation.


Colorectal Carcinoma Metastatic in the Liver

A carcinoma that originates from the colorectal area and has spread to the liver.


Metastatic PRETEX I Hepatoblastoma

PRETEX I hepatoblastoma with distant metastases. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Small Progressed Hepatocellular Carcinoma

A well to moderately differentiated small hepatocellular carcinoma. It is characterized by the presence of obvious stromal invasion and increase atypia compared with early hepatocellular carcinoma.


Recurrent Adult Liver Carcinoma

A hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and has recurred after a period of remission.


Grade 3 Joint Infection, CTCAE

Arthroscopic intervention indicated (e.g., drainage) or arthrotomy (e.g., open surgical drainage)


Grade II Prostatic Intraepithelial Neoplasia

High grade prostatic intraepithelial neoplasia characterized by the presence of moderate architectural and cytologic abnormalities.


recurrent childhood acute myeloid leukemia

The reemergence of acute myeloid leukemia in childhood after a period of remission.


Testicular Tumor of the Thecoma/Fibroma Group

A group of rare, slow-growing stromal tumors that arise from the testis.  This category includes thecoma and fibroma.


Testicular Signet Ring Stromal Tumor

An extremely rare tumor that arises from the testis. It is characterized by the proliferation of epithelioid cells with signet ring appearance separated by fibrous tissue into trabeculae and nests. The histologic features are bland and there is no mucin production. Mutations of CTNNB1 gene have been identified in the reported cases. It is considered a special type of sex cord-stromal tumor. All reported cases had a benign clinical course without metastases.


Grade 4 Uterine Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Childhood Unfavorable Prognosis Hodgkin Lymphoma

A Hodgkin lymphoma with unfavorable prognosis that occurs during childhood.


Acquired Factor III Deficiency

An acquired coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Factor III deficiency

A coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Factor III Inactivation

Presence of inactivating antibodies to tissue factor (factor III) in the blood.


Hereditary Factor III Deficiency

An autosomal recessive, inherited coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Grade 4 Nodal or Junctional Rhythm, CTCAE


Acardius

A severe form of twin-twin transfusion syndrome that occurs in monochorionic pregnancies. The normal twin (pump twin) supplies the blood flow to its sibling that lacks heart or brain or both (acardiac/acephalic twin). Untreated, it may lead to the demise of the pump twin in some cases.


Suture Abrasion

Wearing away of the surface of a suture as a result of bending and frictional forces.


skin abrasion

Superficial damage to the skin caused by rubbing or scraping.


Parkinson Disease 14, Autosomal Recessive

An autosomal recessive subtype of Parkinson disease, caused by mutation(s) in the PLA2G6 gene, encoding 85/88 kDa calcium-independent phospholipase A2.


Parkinsonism with Polyneuropathy

An autosomal dominant subtype of Parkinson disease, caused by mutation(s) in the UQCRC1 gene, encoding cytochrome b-c1 complex subunit 1, mitochondrial.


Parkinson Disease 17

An autosomal dominant subtype of Parkinson disease, caused by mutation(s) in the VPS35 gene, encoding vacuolar protein sorting-associated protein 35.


Parkinson Disease 2, Autosomal Recessive Juvenile

An autosomal recessive subtype of Parkinson disease, caused by mutation(s) in the PRKN gene, encoding E3 ubiquitin-protein ligase parkin.


Parkinson Disease 1, Autosomal Dominant

An autosomal dominant subtype of Parkinson disease, caused by mutation(s) in the SNCA gene, encoding alpha-synuclein. Mutation(s) in the SNCA gene are responsible for PARK4 and Lewy body dementia, and have overlapping phenotypes.


Parkinson Disease 15, Autosomal Recessive Early-Onset

An autosomal recessive subtype of Parkinson disease, caused by mutation(s) in the FBXO7 gene, encoding F-box only protein 7.


Parkinson Disease 4, Autosomal Dominant

An autosomal dominant subtype of Parkinson disease, caused by mutation(s) in the SNCA gene, encoding alpha-synuclein. Mutation(s) in the SNCA gene are responsible for PARK1 and Lewy body dementia, and have overlapping phenotypes.


Parkinson Disease 19B, Early-Onset

An autosomal recessive subtype of Parkinson disease, caused by mutation(s) in the DNAJC6 gene, encoding putative tyrosine-protein phosphatase auxilin. It is characterized by an onset of Parkinsonism between the third and fifth decades. Mutations(s) in DNAJC6, are also causative in PARK19A.


Parkinson Disease 7, Autosomal Recessive Early-Onset

An autosomal recessive subtype of Parkinson disease, caused by mutation(s) in the PARK7 gene, encoding Parkinson disease protein 7.


Parkinson Disease 8, Autosomal Dominant

An autosomal dominant subtype of Parkinson disease, caused by mutation(s) in the LRRK2 gene, encoding leucine-rich repeat serine/threonine-protein kinase 2.


Parkinson Disease 19A, Juvenile-Onset

An autosomal recessive subtype of Parkinson disease, caused by mutation(s) in the DNAJC6 gene, encoding putative tyrosine-protein phosphatase auxilin. It is characterized by an onset of Parkinsonism in the first or second decade. Mutations(s) in DNAJC6, are also causative in PARK19B.


Grade 5 Necrotizing Enterocolitis, AE

A necrotizing enterocolitis adverse event in a newborn which results in death.


Grade 3 Jugular Vein Intra-Operative Injury, CTCAE


Benign neoplasm of supraglottis

A neoplasm that arises from the supraglottis and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Acute Myeloid Leukemia without Maturation

An acute myeloid leukemia without maturation occurring in children.


Grade 3 Tracheal Fistula, CTCAE

Invasive intervention indicated


Pulmonary and Upper Respiratory Fistula, CTCAE


Grade 3 Laryngeal Fistula, CTCAE

Invasive intervention indicated


Grade 1 Oral Cavity Pulmonary Fistula, CTCAE


Grade 2 Laryngeal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 3 Oral Cavity Pulmonary Fistula, CTCAE


Laryngeal Fistula, CTCAE

A disorder characterized by an abnormal communication between the larynx and another organ or anatomic site.


Grade 4 Pharynx Pulmonary Fistula, CTCAE


Grade 4 Oral Cavity Pulmonary Fistula, CTCAE


Tracheal Fistula, CTCAE

A disorder characterized by an abnormal communication between the trachea and another organ or anatomic site.


Grade 5 Laryngeal Fistula, CTCAE

Death


Grade 4 Laryngeal Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Oral Cavity Pulmonary Fistula, CTCAE


Grade 5 Pharynx Pulmonary Fistula, CTCAE


Grade 3 Pharynx Pulmonary Fistula, CTCAE


Grade 1 Laryngeal Fistula, CTCAE

Asymptomatic


Grade 1 Tracheal Fistula, CTCAE

Asymptomatic


Grade 2 Pharynx Pulmonary Fistula, CTCAE


Grade 1 Pharynx Pulmonary Fistula, CTCAE


Parasite-Related Carcinoma

A term that refers to a group of carcinomas that are caused by parasites.


Schistosoma Hematobium-Related Bladder Squamous Cell Carcinoma

A squamous cell carcinoma of the bladder that is caused by Schistosoma hematobium.


Schistosoma Hematobium-Related Bladder Verrucous Carcinoma

A verrucous squamous cell carcinoma of the bladder that is caused by Schistosoma hematobium.


Metastatic malignant neoplasm to choroid

A malignant neoplasm that has spread to the choroid from another anatomic site.


Gallbladder Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the gallbladder.


Childhood Osteochondroma

An osteochondroma that occurs during childhood.


Osteochondromatosis

An autosomal dominant neoplastic chondrogenic process affecting multiple sites. It is caused by mutations in the EXT1 or EXT2 genes.  Grossly and microscopically, the lesions resemble an osteochondroma.


Childhood Chondroblastoma

A chondroblastoma that occurs during childhood.


Maxillofacial Chondroblastoma

A benign chondroid-producing neoplasm arising in a maxillofacial bone.


Laryngeal Chondroma

A benign neoplasm arising from hyaline cartilage of the larynx. It is characterized by the presence of chondrocytes, a lobulated growth pattern, and calcification.


Maxillofacial Chondroma

A benign neoplasm of hyaline cartilage that arises within the medullary cavity of a maxillofacial bone. It is characterized by the presence of chondrocytes, a lobulated growth pattern, and calcification.


Childhood Chondromyxoid Fibroma

A chondromyxoid fibroma that occurs during childhood.


Childhood Subungual Exostosis

Subungual exostosis that occurs during childhood.


Maxillofacial Chondromyxoid Fibroma

An uncommon benign cartilaginous neoplasm arising in a maxillofacial bone. It is characterized by the presence of spindle-shaped or stellate chondrocytes, a lobulated growth pattern, myxoid stroma formation, and sometimes multinucleated giant cells.


Chondromatosis

A multifocal benign neoplasm arising from bone or soft tissue.  It is characterized by the presence of chondrocytes and is composed of hyaline cartilage.


Bizarre parosteal osteochondromatous proliferation

A benign lesion that usually affects the proximal small bones of the hands or feet.  Grossly it consists of a cartilage cap and a bony stalk.  Microscopically it is characterized by the presence of spindle cells, cartilage, and bone, usually in a disorganized pattern compared to subungual exostosis.  Enlarged (bizarre) chondrocytes are present in the cartilage.  Swelling with or without pain is present.  Recurrences following resection have been reported in approximately half of cases.


Solitary Osteochondroma

An osteochondroma affecting a single anatomical site.


hemisuccinate

A succinate ester in which only one of the carboxy groups of succinic acid has been esterified.


Tactile Disorder

Conditions characterized by an alteration in the ability to perceive touch.


Uterine Obstruction

Blockage of the uterine outlet. Causes include uterine tumors and adhesions.


Refractory Lymphoma

A lymphoma that does not respond to treatment.


Refractory Central Nervous System Lymphoma

Central nervous system lymphoma that is resistant to treatment.


Refractory Primary Cutaneous Lymphoma

Primary cutaneous lymphoma that does not respond to treatment.


Refractory EBV-Related Lymphoma

EBV-related lymphoma that is resistant to treatment.


Hodgkin's disease mixed cellularity refractory

Mixed cellularity classic Hodgkin lymphoma that is resistant to treatment.


Classical Hodgkin lymphoma refractory

Classic Hodgkin lymphoma that is resistant to treatment.


Refractory Primary Bone Lymphoma

Primary lymphoma of bone that is resistant to treatment.


Refractory Hodgkin Lymphoma

Hodgkin lymphoma resistant to treatment


Hodgkin's disease nodular sclerosis refractory

Nodular sclerosis classic Hodgkin lymphoma that is resistant to treatment.


Refractory Lymphocyte-Rich Classic Hodgkin Lymphoma

Lymphocyte-rich classic Hodgkin lymphoma that does not respond to treatment.


Hodgkin's disease lymphocyte depletion type refractory

Lymphocyte-depleted classic Hodgkin lymphoma that is resistant to treatment.


Laryngeal Neuroendocrine Tumor G1

A well-differentiated, low grade neuroendocrine neoplasm that arises from the larynx.


Head and Neck Neuroendocrine Tumor

A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the head and neck.


Head and Neck Neuroendocrine Tumor G2

A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the head and neck.


Laryngeal Neuroendocrine Tumor

A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the larynx.


Head and Neck Neuroendocrine Tumor G1

A well-differentiated, low grade neuroendocrine neoplasm that arises from the head and neck.


Laryngeal Neuroendocrine Tumor G2

A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the larynx.


Grade 4 Intestinal Stoma Obstruction, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Refractory Bladder Small Cell Neuroendocrine Carcinoma

Bladder small cell neuroendocrine carcinoma that is resistant to treatment.


18,25-dihydroxyvitamin D3 / 18,25-dihydroxycholecalciferol


vitamin D4

It is present in mushrooms.


1alpha,25-dihydroxy-11alpha-methoxyvitamin D3 / 1alpha,25-dihydroxy-11alpha-methoxycholecalciferol


1alpha,25-dihydroxy-2beta-(6-hydroxyhexyl)vitamin D3 / 1alpha,25-dihydroxy-2beta-(6-hydroxyhexyl)cholecalciferol


1,25-dihydroxy-22-oxavitamin D3 3-hemiglutarate/ 1,25-dihydroxy-22-oxacholecalciferol 3-hemiglutarate


(6R)-vitamin D2 6,19-sulfur dioxide adduct / (6R)-ergocalciferol 6,19-sulfur dioxide adduct


previtamin D3

A hydroxy seco-steroid which is an intermediate in the production of vitamin D3 in human skin.


23(S),25-dihydroxy-24-oxovitamin D3

A hydroxycalciol that is 25-hydroxyvitamin D3 carrying an additional hydroxy group at position 23 (with 23S-configuration) and an oxo group at position 24. An intermediate in the degradation pathway of 25-OH-vitamin D3.


24-(dimethoxyphosphoryl)-25,26,27-trinorvitamin D3 / 24-(dimethoxyphosphoryl)-25,26,27-trinorcholecalciferol


(20S,24S)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 and 24 (both with S-configuration).


2alpha-chloro-1beta,25-dihydroxyvitamin D3 / 2alpha-chloro-1beta,25-dihydroxycholecalciferol


(20S)-1alpha,20,25-trihydroxy-24a-homovitamin D3 / (20S)-1alpha,20,25-trihydroxy-24a-homocholecalciferol


(6R)-vitamin D3 6,19-(4-phenyl-1,2,4-triazoline-3,5-dione) adduct


(24R)-6,19-epidioxy-1,24-dihydroxy-6,19-dihydrovitamin D3 / (24R)-6,19-epidioxy-1,24-di hydroxy-6,19-dihydrocholecalciferol


1alpha,25-dihydroxy-24-oxo-23-azavitamin D2 / 1alpha,25-dihydroxy-24-oxo-23-azaergocalciferol


(24R,25S)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24R,25S)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


(23R)-1alpha,23,25-trihydroxy-23-methylvitamin D3 / (23R)-1alpha,23,25-trihydroxy-23-methylcholecalciferol


25-hydroxy-16,17-didehydrovitamin D3 / 25-hydroxy-16,17-didehydrocholecalciferol


1alpha,25-dihydroxy-18-oxovitamin D3 / 1alpha,25-dihydroxy-18-oxocholecalciferol


calcidiol 3-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 3 has been replaced by a beta-D-glucuronyl residue.


1alpha,25-dihydroxy-11alpha-(hydroxymethyl)vitamin D3 / 1alpha,25-dihydroxy-11alpha-(hydroxymethyl)cholecalciferol


1alpha,24,25,28-tetrahydroxyvitamin D2 / 1alpha,24,25,28-tetrahydroxyergocalciferol


1alpha,25-dihydroxy-(26,26)-(27,27)-diethanovitamin D3 / 1alpha,25-dihydroxy-(26,26)-(27,27)-diethanocholecalciferol


1,24(S)-dihydroxyvitamin D2

Metabolite of vitamin D2. It  present in the circulation of humans, cows, and rats given pharmacologic doses of vitamin D2


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity.


(20S)-hydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying an additional hydroxy group at position 20 with S-configuration.


18-acetoxy-1alpha-hydroxyvitamin D3

A hydroxycalciol that is calciol with an additional hydroxy group at position C-1 and an acetoxy group at C-18.


1alpha,25-dihydroxy-24a,24b-dihomo-23-oxavitamin D3 / 1alpha,25-dihydroxy-24a,24b-dihomo-23-oxacholecalciferol


(20S,23)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 23.


(25R)-26,26,26-trifluoro-1alpha,25-dihydroxyvitamin D3 / (25R)-26,26,26-trifluoro-1alpha,25-dihydroxycholecalciferol


1alpha-Hydroxy-25,26,27-trinorvitamin D3 24-carboxylic acid


1alpha,25-dihydroxy-20-epivitamin D2 / 1alpha,25-dihydroxy-20-epiergocalciferol


(23Z)-25-hydroxy-16,17,23,24-tetradehydrovitamin D3 / (23Z)-25-hydroxy-16,17,23,24-tetradehydrocholecalciferol


(23S,25R)-25-hydroxyvitamin D3 26,23-lactol / (23S,25R)-25-hydroxycholecalciferol 26,23-lactol


vitamin D5

A vitamin D in which the side-chain at position 17 consists of a (5R)-5-ethyl-6-methylheptan-2-yl group.


(20S)-1alpha,25-dihydroxy-20-methoxyvitamin D3 / (20S)-1alpha,25-dihydroxy-20-methoxycholecalciferol


1alpha,25-dihydroxy-24a,24b-dihomo-22-oxavitamin D3 / 1alpha,25-dihydroxy-24a,24b-dihomo-22-oxacholecalciferol


(24R)-1alpha,24,25,26-tetrahydroxyvitamin D2 / (24R)-1alpha,24,25,26-tetrahydroxyergocalciferol


(24S,25S)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24S,25S)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


23,23-difluoro-1alpha,25-dihydroxyvitamin D3 / 23,23-difluoro-1alpha,25-dihydroxycholecalciferol


1alpha,25-dihydroxy-24a-homo-22-thiavitamin D3 / 1alpha,25-dihydroxy-24a-homo-22-thiacholecalciferol


1alpha,25-Dihydroxyvitamin D3 25-trimethylsilyl ether


(24S,25R)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24S,25R)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


1alpha,2beta,25-trihydroxy vitamin D3

A hydroxy seco-steroid that is calciol carrying three additional hydroxy substituents at positions 1alpha, 2beta and 25.


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity


D3 vitamins

A vitamin D that is calciol or its hydroxylated metabolites calcidiol and calcitriol. Calciol (also known as vitamin D3) acts as a hormone precursor, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.


A hydroxycalciol that is calcitriol with an acetoxy group at C-18.


1alpha,25-dihydroxy-24-nor-22-oxavitamin D3 / 1alpha,25-dihydroxy-24-nor-22-oxacholecalciferol


25-hydroxyvitamin D2

A hydroxycalciol that is vitamin D2 in which the hydrogen at position 25 has been replaced by a hydroxy group.


5,6-trans-vitamin D3

A member of the class of D3 vitamins that is calciol in which the double bond at position 5 adopts a trans-configuration. During exposure to sunlight, previtamin D3 and vitamin D3 in the skin become photoisomerized to 5,6-trans-vitamin D3.


(20S,24R)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration) and 24 (with R-configuration).


20(S),25-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 25.


1alpha,25-dihydroxyvitamin D2

A hydroxycalciol that is vitamin D2 bearing additional hydroxy substituents at positions 1alpha and 25.


26,26,26-trifluoro-25-hydroxyvitamin D3 / 26,26,26-trifluoro-25-hydroxycholecalciferol


calcidiol 25-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 25 has been replaced by a beta-D-glucuronyl residue.


1alpha,25-dihydroxy-11beta-methoxyvitamin D3 / 1alpha,25-dihydroxy-11beta-methoxycholecalciferol


(24R,25R)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24R,25R)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


Grade 2 Jejunal Obstruction, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Grade 2 Head Soft Tissue Necrosis, CTCAE

Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Splenic Plasmacytoma

A plasmacytoma that arises in the spleen.


Littoral Cell Angioma

A very rare benign vascular neoplasm that is unique to the spleen and is characterized by vascular proliferations with a hybrid endothelial-histiocytic phenotype. Most patients are asymptomatic, and the tumor is discovered incidentally on imaging studies performed for other reasons.


Splenic B-Cell Lymphoma/Leukemia, Unclassifiable

A small B-cell clonal lymphoproliferative disorder of the spleen that does not fall into any of the other categories of mature B-cell neoplasms.


Malignant Splenic Soft Tissue Neoplasm

A malignant mesenchymal neoplasm that arises from the spleen.


Recurrent Hairy Cell Leukemia Variant

The reemergence of hairy cell leukemia variant after a period of remission.


Splenic Manifestation of Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Infiltration and expansion of the red pulp and sinusoids of the spleen by chronic myeloid leukemia, BCR-ABL1 positive.


Splenic Manifestation of B-Cell Prolymphocytic Leukemia

Infiltration and expansion of the white and red pulp of the spleen by B-cell prolymphocytic leukemia.


Extramedullary Disease in Plasma Cell Myeloma Involving the Spleen

Infiltration of the spleen by malignant (clonal) plasma cells in patients with history of multiple myeloma


Sclerosing Angiomatoid Nodular Transformation of Spleen

A benign, circumscribed lesion that arises from the spleen and is composed of multiple angiomatoid nodules in a fibrosclerotic stroma. It most often affects middle-aged females. It is usually asymptomatic, and most cases are detected incidentally on imaging studies.


Splenic Manifestation of T-Cell Prolymphocytic Leukemia

Infiltration and expansion of the white and red pulp of the spleen by T-cell prolymphocytic leukemia.


Malignant lymphoma of spleen

A non-Hodgkin lymphoma or rarely Hodgkin lymphoma that arises from the spleen.


Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia

Infiltration and expansion of the red pulp cords and sinusoids of the spleen by T-cell large granular lymphocyte leukemia. The white pulp of the spleen is not involved and is often hyperplastic.


thiazolidinediones

A thiadiazolidine in which the 1,3-thiazolidine ring is substituted by two oxo groups.


Paratesticular Paraganglioma

An extremely rare paraganglioma that arises from the paratesticular structures.


Myeloid Neoplasms with Germline Predisposition Associated with Other Organ Dysfunction

Familial hematologic neoplasms associated with germline mutations and a preexisting disorder or organ dysfunction other than a platelet disorder.


Myeloid Neoplasms with Germline Predisposition Associated with Inherited Bone Marrow Failure Syndromes

Familial myelodysplastic syndromes/ acute myeloid leukemias associated with inherited bone marrow failure syndromes.


Myeloid Neoplasms with Germline GATA2 Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline GATA2 mutation.


Myeloid Neoplasms with Germline SAMD9 Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9 mutation.


Myeloid Neoplasms with Germline SAMD9L Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9L mutation.


Juvenile Myelomonocytic Leukemia Associated with Neurofibromatosis

Juvenile myelomonocytic leukemia that is associated with neurofibromatosis type 1 (NF1).


Juvenile Myelomonocytic Leukemia Associated with Noonan Syndrome-Like Disorder

Juvenile myelomonocytic leukemia that is associated with a genetic disorder caused by germline mutations in the CBL gene and phenotypically resembles Noonan syndrome (Noonan syndrome-like disorder).


Myeloid Proliferations Associated with Down Syndrome

Hematologic neoplasms occurring in individuals with Down syndrome.  There is an increased risk of acute leukemias in both children and adults with Down syndrome.  In particular, the incidence of acute myeloid leukemia in Down syndrome children of less than five years of age is particularly high, it is usually an acute megakaryoblastic leukemia, and is associated with GATA1 gene mutation.  This group of disorders also includes the entity transient abnormal myelopoiesis which occurs in neonates and is associated with GATA1 gene mutation.


Myeloid Neoplasms with Germline Predisposition Associated with Telomerase Biology Disorders

Familial myelodysplastic syndromes/ acute myeloid leukemias associated with telomerase biology disorders.


Serous Tubal Intraepithelial Lesion

A non-invasive, precursor epithelial proliferation that arises from the fallopian tube, lacks severe atypia, and demonstrates serous differentiation.


Fracture of Ulna Related to Birth

A broken ulna sustained during the birthing process.


Closed Monteggia's fracture

Proximal radial head dislocation in association with a proximal ulnar fracture that does not involve a break in the adjacent skin.


Fracture of Clavicle Related to Birth

An injury sustained during the birthing process in which the continuity is broken in the clavicle.


Fracture of Femur Related to Birth

A broken femur sustained during the birthing process.


Closed fracture of rib

A traumatic break in one of the bones in the rib cage that does not involve a break in the adjacent skin.


Fracture of metacarpal bone

A traumatic break in one or more of the metacarpal bones.


Closed fracture of shaft of metacarpal bone

A traumatic break in the diaphysis of the metacarpal bone that does not involve a break in the adjacent skin.


Closed fracture of multiple ribs

A traumatic break in two or more places in one rib, or a traumatic break in more than one rib, that does not involve a break in the adjacent skin.


Closed fracture of pelvis

A traumatic break in one or more of the bones comprising the bony structure of the pelvis that does not involve a break in the adjacent skin.


Open fracture of rib

A traumatic break in one of the bones in the rib cage  that involves a break in the adjacent skin.


Closed fracture of metacarpal bone

A traumatic break in one or more of the metacarpal bones that does not involve a break in the adjacent skin.


Fracture of mandible, closed

A traumatic break in the mandible  that does not involve a break in the adjacent skin.


Closed fracture of malar AND/OR maxillary bones

A traumatic break in the malar and maxillary bones  that does not involve a break in the adjacent skin.


Fracture Related to Birth

A broken bone sustained during the birthing process.


Closed fracture of neck of metacarpal bone

A traumatic break in the area of the metacarpal bone located between the diaphysis and the distal metaphysis that does not involve a break in the adjacent skin.


Fracture of bone involving growth plate

A traumatic break in a long bone that involves the epiphyseal plate.


Lumbar vertebral fracture L2

A traumatic break in the second lumbar spinal vertebra.


Fracture of Humerus Related to Birth

A broken humerus sustained during the birthing process.


Fracture of phalanx of finger

A traumatic break in one or more of the bones in one of the digits of the hand.


Open fracture of neck of metacarpal bone

A traumatic break in the area of the metacarpal bone located between the diaphysis and the distal metaphysis that involves a break in the adjacent skin.


Closed Colles' fracture

An extra-articular traumatic break in the distal radius with dorsal displacement of the distal fragment that does not involve a break in the adjacent skin.


Fracture of Spine Related to Birth

A broken vertebra sustained during the birthing process.


Fracture of Radius Related to Birth

A broken radius sustained during the birthing process.


Colles' Fracture

An extra-articular traumatic break in the distal radius with dorsal displacement of the distal fragment.


Open fracture of pelvis

A traumatic break in one or more of the bones comprising the bony structure of the pelvis that involves a break in the adjacent skin..


Fracture of Skull Related to Birth

An injury sustained during the birthing process in which the continuity is broken in the skull.


Limb fracture

A traumatic break in one or more bones in a limb.


Open fracture of metacarpal bone

A traumatic break in one or more of the metacarpal bones that involves a break in the adjacent skin.


Fracture of Nose Related to Birth

A broken nasal bone sustained during the birthing process.


Grade 2 Vaginal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Parotid Gland Lymphangioma

A lymphangioma arising from the parotid gland.


dichlorobenzene

Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.


A member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1.


(S)-fenticonazole

A 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole that is the (S)-enantiomer of fenticonazole.


(S)-econazole

A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of econazole.


(S)-butoconazole

The (S)-enantiomer of butoconazole.


(S)-tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of tioconazole.


(R)-econazole

A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of econazole.


clonidine (amino form)

A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.


(R)-fenticonazole

A 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole that is the (R)-enantiomer of fenticonazole.


(S)-miconazole

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has S) configuration.


(S)-enilconazole

A 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that is the (S)-enantiomer of enilconazole


(R)-enilconazole

A 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that is the (R)-enantiomer of enilconazole.


arasertaconazole

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the active R-enantiomer of sertaconazole and is used (as its nitrate salt) for treatment of vulvovaginal candidiasis. The racemate itself is also used as a broad-spectrum antifungal drug.


(R)-butaconazole

The (R)-enantiomer of butaconazole.


(R)-miconazole

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has R configuration.


A salicylanilide derivative with chloride substituents at C-3 and C-5 of the salicylate moiety and at C-3 and C-4 of the anilide moiety.


(R)-tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of tioconazole.


(S)-sertaconazole

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of sertaconazole.


A pyrazolylpiperidine that consists of 4-(pyrazol-1-yl)piperidine carrying a 2-amino-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-5-yl group at the 4-position of the pyrazole ring.


Stage IV Adrenal Cortex Carcinoma AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


A sympathetic paraganglioma arising from the retroperitoneum, outside the adrenal gland.


Childhood Adrenal Cortical Carcinoma

A carcinoma that arises from the adrenal cortex and occurs during childhood.


Retroperitoneal Ganglioneuroma

A ganglioneuroma arising from the retroperitoneum.


Adrenal Cortical Carcinoma by AJCC v7 Stage

A term that refers to the staging of adrenal cortical carcinoma, following the rules of the TNM AJCC v7 classification system.


Adrenal Cortical Oncocytic Carcinoma

A carcinoma that arises from the adrenal cortex and is composed of oncocytic cells that constitute more than 90% of malignant cells.


Stage III Adrenal Cortex Carcinoma AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0); (T4, Any N, M0). T1: Tumor measuring 5 cm or less in greatest dimension, with no extra-adrenal invasion. T2: Tumor measuring more than 5 cm in greatest dimension, with no extra-adrenal invasion. T3: Tumor of any size with local invasion but not invading adjacent organs. T4: Tumor of any size that invades adjacent organs (kidney, diaphragm, pancreas, spleen, or liver) or large blood vessels (renal vein or vena cava). N1: Metastasis in regional lymph node(s). M0: No distant metastasis. (from AJCC 8th Ed.)


Adrenal Cortical Carcinoma by AJCC v8 Stage

A term that refers to the staging of adrenal cortical carcinoma, following the rules of the TNM AJCC v8 classification system. Adrenal medullary pheochromocytoma is staged according to the classification for adrenal neuroendocrine tumors. There is no AJCC staging system for neuroblastic tumors of the adrenal gland. (from AJCC 8th Ed.)


Adrenal Cortical Oncocytic Adenoma

A usually non-functioning variant of adrenal cortex adenoma, composed of large cells with abundant granular eosinophilic cytoplasm.


Glomerulosa Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of neoplastic cells with cytologic features of glomerulosa cells.


Stage III Adrenal Cortex Carcinoma AJCC v7

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0).  T1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion.  T2: Tumor greater than 5 cm, no extra-adrenal invasion.  T3: Tumor of any size with local invasion, but not invading adjacent organs.  N1: Metastasis in regional lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adrenal Gland Ganglioneuroma

A ganglioneuroma arising from the adrenal gland.


Adrenal Gland Lipoma

A rare lipoma that arises from the adrenal gland.


Recurrent Adrenal Gland Pheochromocytoma

The reemergence of pheochromocytoma following surgical removal.


Clear Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of neoplastic clear cells containing intracytoplasmic lipid droplets.


Stage IV Adrenal Cortex Carcinoma AJCC v7

Stage IV includes: (T3, N1, M0); (T4, N0, M0); (T4, N1, M0); (Any T, Any N, M1).  T3: Tumor of any size with local invasion, but not invading adjacent organs.  T4: Tumor of any size with invasion of adjacent organs.  N1: Metastasis in regional lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. M1: Distant metastasis.  (AJCC 7th ed.)


Retroperitoneal Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor that arises from the retroperitoneum. This is an extragastrointestinal tumor, meaning that it does not arise directly from the gastrointestinal tract.


Leiomyoma of the adrenal gland

A rare leiomyoma that arises from the adrenal gland.


Benign neoplasm of retroperitoneum

A neoplasm that arises from the retroperitoneum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Benign neoplasm of adrenal cortex

A neoplasm that arises from the adrenal cortex and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Adrenal Cortical Adenoma

An adenoma of the adrenal cortex that occurs during childhood.


Stage I Adrenal Cortex Carcinoma AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Hereditary Adrenal Gland Pheochromocytoma

A hereditary adrenal gland pheochromocytoma caused by mutations in SDHB, SDHC, and SDHD genes.


Adrenal Cortical Adenomatoid Tumor

A benign adrenal cortical neoplasm deriving from mesothelial cells.


Locally Advanced Adrenal Gland Pheochromocytoma

Adrenal gland pheochromocytoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adrenal Cortical Myxoid Carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the presence of abundant extracellular connective tissue mucin.


Locally Advanced Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adrenal Gland Lymphangioma

A rare lymphangioma that arises from the adrenal gland.


Stage II Adrenal Cortex Carcinoma AJCC v7

Stage II includes: T2, N0, M0.  T2: Tumor greater than 5 cm, no extra-adrenal invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adrenal Gland Lymphoma

A rare lymphoma that arises from the adrenal gland.


Adrenal Cortical Low Grade Carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the presence of twenty or less mitoses per ten square millimeters.


Metastatic Adrenal Gland Composite Pheochromocytoma

An adrenal gland composite pheochromocytoma that metastasizes to other anatomic sites.


Metastatic Adrenal Cortical Carcinoma

A carcinoma that arises from the adrenal cortex and has metastasized to another anatomic site.


Adrenal Gland Hemangioma

A rare hemangioma that arises from the adrenal gland.


Superior and Inferior Paraaortic Paraganglioma

An extra-adrenal sympathetic paraganglioma arising from paraganglia located along the aorta, including suprarenal, infrarenal, and renal hilar sites.  In functional tumors, the hypersecretion of catecholamines results in hypertension.


Metastatic Carcinoma in the Adrenal Cortex

A carcinoma that has spread to the adrenal cortex from an adjacent or distal anatomic site.


Androgen-Producing Adrenal Cortical Adenoma

A rare adenoma of the adrenal cortex that produces androgens.  Female patients usually have symptoms related to virilism.


Unresectable Adrenal Gland Pheochromocytoma

Adrenal gland pheochromocytoma that is not amenable to surgical resection.


Compact Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of neoplastic compact cells with eosinophilic cytoplasm.


Adrenal Cortical Sex Cord-Stromal Tumor

An extremely rare sex cord-stromal tumor that arises from the adrenal cortex. The reported cases were solitary and unilateral.


Adrenal Gland Composite Pheochromocytoma

A neoplasm that arises from the adrenal medulla and combines morphologic characteristics of pheochromocytoma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor.


Adrenal Gland Ganglioneuroblastoma, Intermixed

An intermixed ganglioneuroblastoma arising from the adrenal gland.


Adrenal Cortical High Grade Carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the presence of more than twenty mitoses per ten square millimeters.


Stage I Adrenal Cortex Carcinoma AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor measuring 5 cm or less in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Advanced Adrenal Gland Pheochromocytoma

An adrenal gland pheochromocytoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adrenal Cortical Melanoma

A rare melanoma that arises within the adrenal cortex.


Adrenal Gland Schwannoma

A rare schwannoma that arises from the adrenal medulla.


Mixed Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of a mixed neoplastic cellular population, including varying numbers of neoplastic clear and compact cells.


Stage II Adrenal Cortex Carcinoma AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor measuring more than 5 cm in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Adrenal Gland Ganglioneuroblastoma, Nodular

A nodular ganglioneuroblastoma arising from the adrenal gland.


Unresectable Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that is not amenable to surgical resection.


Recurrent Malignant Retroperitoneal Neoplasm

The reemergence of a malignant retroperitoneal neoplasm after a period of remission.


Non-Metastatic Adrenal Gland Composite Pheochromocytoma

A composite pheochromocytoma that is confined to the adrenal gland.


Regional Adrenal Gland Pheochromocytoma

A pheochromocytoma that has not spread to other regions.


Heavily Pigmented Adrenal Cortical Adenoma

A usually functioning adenoma of the adrenal cortex. Grossly, it has a dark brown appearance and is characterized by the presence of neoplastic cells containing abundant intracytoplasmic lipofuscin. It may be associated with Cushing syndrome.


Recurrent Adrenal Cortical Carcinoma

The reemergence of adrenal cortical carcinoma after a period of remission.


Anaplastic adrenocortical carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the partial or complete loss of adrenal cortical differentiation.


Refractory Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that is resistant to treatment.


estrogen-producing adrenal cortical adenoma

A rare adenoma of the adrenal cortex that produces estrogens.  Male patients may develop gynecomastia and impotence.


Grade 1 Conjunctivitis, CTCAE

Asymptomatic or mild symptoms; intervention not indicated


Grade 5 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute Myeloid Leukemia with Complex Karyotype

Acute myeloid leukemia associated with at least 3 unrelated clonal chromosomal abnormalities.


Forceps Injury

Birth injury sustained during a forceps-assisted delivery.


Grade 5 Pericardial Tamponade, CTCAE

Death


Grade 1 Upper Extremity Vein Injury, CTCAE


Grade 4 Upper Extremity Vein Injury, CTCAE


Grade 2 Upper Extremity Vein Injury, CTCAE


Grade 5 Upper Extremity Vein Injury, CTCAE


Childhood Neuroblastoma by Toronto Guidelines v2 Stage

A term that refers to the staging of childhood neuroblastoma according to the Toronto childhood cancer staging guidelines v2.


Familial Adenomatous Polyposis Associated Medulloblastoma

A medulloblastoma developing in patients with familiar adenomatous polyposis syndrome.  It is observed in patients with Turcot syndrome, type 2.


Medulloblastoma, SHH-4

Medulloblastoma, SHH-activated, characterized by mutations of U1-snRNA and TERT genes. Mutations of PTCH1 or SMO genes are usually also present. It affects mostly adults.


Sellar Neuroblastoma

A rare neuroblastoma arising from the sella turcica.


Refractory Ganglioneuroblastoma

Ganglioneuroblastoma that does not respond to treatment.


Embryonal Tumor with Multilayered Rosettes, DICER1-Mutated

An embryonal tumor with multilayered rosettes characterized by the presence of DICER1 mutation. Approximately half of embryonal tumors with multilayered rosettes that lack a C19MC alteration carry DICER1 mutations.


Refractory Dedifferentiated Chordoma

A dedifferentiated chordoma that does not respond to treatment.


Childhood Brain Neuroblastoma

A neuroblastoma that arises from the brain during childhood.


Refractory Rhabdoid Tumor

Rhabdoid tumor that does not respond to treatment.


Stage M1 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

Tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Hereditary Neuroblastoma

Genetic inheritance of neuroblastoma caused by mutations in the ALK or PHOX2B genes.  Familial neuroblastomas have a higher incidence of multiple primary tumors and are diagnosed at an earlier age.


Childhood Central Nervous System Ganglioneuroblastoma

A central nervous system ganglioneuroblastoma that occurs during childhood.


Stage L1 Childhood Neuroblastoma by Toronto Guidelines v2

Localized tumor that does not involve any vital structures as defined by the list of IDRFs (i.e., there are no IDRFs) and the tumor must be confined within one body compartment, neck, chest, abdomen, or pelvis. An intraspinal tumor extension that does not fulfill the criteria for an IDRF is consistent with stage L1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Advanced Chordoma

A chordoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Central Nervous System Embryonal Tumor, Not Otherwise Specified with Leptomeningeal Spread

A central nervous system embryonal tumor, not otherwise specified which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.


Visual Pathway Medulloepithelioma

A very rare, benign or malignant embryonal neoplasm affecting the visual pathway during childhood. It arises from primitive medullary epithelium.


Stage M4 Medulloblastoma

Metastasis outside the cerebrospinal axis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Stage M3 Childhood Medulloblastoma by Toronto Guidelines v2

Visible metastasis in spine or visible metastasis in cervicomedullary junction. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Atypical Teratoid/Rhabdoid Tumor-TYR

Atypical teratoid/rhabdoid tumor characterized by overexpression of melanosomal genes (TYR, TYRP, MITF, and OTX2).


nodular medulloblastoma

A medulloblastoma characterized by nodularity and neuronal differentiation.


Stage M3 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2


Neuroblastoma of the Adrenal Gland and Sympathetic Nervous System

A common pediatric extracranial tumor arising from neural crest cells.  It involves the adrenal medulla and the sympathetic nervous system.


Adult Supratentorial Embryonal Tumor, Not Otherwise Specified

A supratentorial embryonal tumor, not otherwise specified that occurs in adults.


An intermixed ganglioneuroblastoma that occurs during childhood.


Anaplastic Medulloblastoma

A medulloblastoma characterized by marked nuclear pleomorphism, and high mitotic activity.


Paratesticular Wilms Tumor

A rare Wilms tumor that arises from the paratesticular structures.


Childhood Neuroblastoma by Toronto Guidelines v2 Stage, Tier 2

A term that refers to the staging of childhood neuroblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


Atypical Teratoid/Rhabdoid Tumor-SHH

Atypical teratoid/rhabdoid tumor characterized by overexpression of genes in the sonic hedgehog (SHH) pathway (GLI2, BOC, PTCHD2, and MYCN).


Prostate Wilms Tumor

A rare Wilms tumor affecting the prostate gland.


Childhood Atypical Teratoid/Rhabdoid Tumor

An atypical teratoid/rhabdoid tumor occurring in children.


Stage M0 Childhood Medulloblastoma by Toronto Guidelines v2

No visible disease on imaging (MRI brain and spine) beyond primary site of disease and no tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Localized Childhood Neuroblastoma by Toronto Guidelines v2

Localized tumor not involving vital structures and confined to one body compartment. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


medulloblastoma SHH activated and TP53 mutant

Medulloblastoma associated with activation of the sonic hedgehog (SHH) pathway and the presence of TP53 mutations.


Localized Resectable Neuroblastoma

Neuroblastoma that is confined to a specific site and is amenable to surgical removal.


Refractory Peripheral Primitive Neuroectodermal Tumor

Peripheral primitive neuroectodermal tumor that does not respond to treatment.


Recurrent Rhabdoid Tumor

The reemergence of rhabdoid tumor after a period of remission.


Thyroblastoma

A high-grade, rapidly growing malignant embryonal neoplasm that arises from the thyroid gland. It is characterized by the presence of primitive follicular-like structures surrounded by primitive small cells and primitive spindle cell mesenchymal stroma. It is associated with DICER1 gene mutations. The prognosis is poor.


Extra-osseous Ewing's sarcoma recurrent

Reemergence of extraskeletal Ewing sarcoma after a period of remission.


Peripheral neuroepithelioma of bone metastatic

A small round cell tumor of the bone with neural differentiation that has spread from its original site of growth to another anatomic site.


Unresectable Ewing Sarcoma

A Ewing sarcoma which is not amenable to surgical resection.


Stage M4 Embryonal Tumor with Multilayered Rosettes

Metastasis outside the cerebrospinal axis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Central Nervous System Embryonal Neoplasm

A malignant neoplasm of embryonal origin, arising from the central nervous system.  It usually affects children.  Representative examples include ependymoblastoma, medulloblastoma, and atypical teratoid/rhabdoid tumor.


Locally Advanced Ewing Sarcoma

Ewing sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Childhood Medulloblastoma by Toronto Guidelines v2 Stage, Tier 1

A term that refers to the staging of childhood medulloblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Stage M1 Pineoblastoma

Microscopic tumor cells are detected in the cerebrospinal fluid. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Sellar Dedifferentiated Chordoma

A dedifferentiated chordoma that arises from the sellar region.


Stage M2 Atypical Teratoid/Rhabdoid Tumor

Gross nodular seeding is detected in the cerebellar/cerebral subarachnoid space or in the third or lateral ventricles. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Stage M0 Atypical Teratoid/Rhabdoid Tumor

No evidence of subarachnoid or hematogenous metastasis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Recurrent Childhood Central Nervous System Embryonal Neoplasm

The reemergence of childhood central nervous system embryonal neoplasm after a period of remission.


Resectable Neuroblastoma

Neuroblastoma that is amenable to surgical resection.


Childhood Brain Ganglioneuroblastoma

A ganglioneuroblastoma that arises from the brain and occurs during childhood.


Stage L2 Childhood Neuroblastoma by Toronto Guidelines v2

Locoregional tumor with one or more IDRFs. The tumor may be ipsilateral contiguous within body compartments (i.e., a left-sided abdominal tumor with left-sided lung, bone or pleura involvement should be considered stage L2). However, a clearly left-sided abdominal tumor with right-sided lung, bone or pleura (or vice-versa) involvement is defined as metastatic disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Neuroblastoma by Toronto Guidelines v2 Stage, Tier 1

A term that refers to the staging of childhood neuroblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


High Risk Neuroblastoma

Neuroblastoma usually presenting with metastatic disease and MYCN gene amplifications.


embryonal tumor with multilayered rosettes

A central nervous system embryonal tumor characterized by the presence of multilayered rosette formation and typically the presence of amplification of the C19MC region on chromosome 19 (19q13.42) or rarely a DICER1 mutation.


Peripheral neuroepithelioma of bone recurrent

The reemergence of peripheral primitive neuroectodermal tumor of the bone after a period of remission.


Cribriform Neuroepithelial Tumor

A very rare, nonrhabdoid, intraventricular tumor with relatively favorable prognosis.  It is characterized by the presence of neuroepithelial cells forming cribriform patterns, trabeculae, epithelial membrane antigen immunopositivity on epithelial surfaces, and loss of nuclear INI 1 expression.


Sellar Chordoma

A chordoma that arises from the sellar region.


The reemergence of medulloblastoma, WNT-activated after a period of remission.


Stage 3 Neuroblastoma

Unresectable unilateral tumor infiltrating across the midline, with or without regional lymph node involvement; or localized unilateral tumor with contralateral regional lymph node involvement; or midline tumor with bilateral extension by infiltration (unresectable) or by lymph node involvement. The midline is defined as the vertebral column. Tumors originating on one side and crossing the midline must infiltrate to or beyond the opposite side of the vertebral column. (cancer.gov)


Refractory Atypical Teratoid/Rhabdoid Tumor

An atypical teratoid/rhabdoid tumor that does not respond to treatment.


Stage 4S neuroblastoma

Localized primary tumor, as defined for stage 1, 2A, or 2B, with dissemination limited to skin, liver, and/or bone marrow (limited to infants younger than 1 year). Marrow involvement should be minimal (i.e., <10% of total nucleated cells identified as malignant by bone biopsy or by bone marrow aspirate). More extensive bone marrow involvement would be considered stage 4 disease. The results of the MIBG scan, if performed, should be negative for disease in the bone marrow. (cancer.gov)


Metastatic Childhood Neuroblastoma by Toronto Guidelines v2

Distant metastatic disease (except stage MS). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2 Stage, Tier 2

A term that refers to the staging of childhood central nervous system embryonal tumor according to the tier 2 Toronto childhood cancer staging guidelines v2.


Localized Childhood Medulloblastoma by Toronto Guidelines v2

Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Medulloblastoma with Leptomeningeal Spread

A medulloblastoma which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.


Unresectable Rhabdoid Tumor

A rhabdoid tumor that is not amenable to surgical resection.


Stage IV Kidney Wilms Tumor

Wilms tumor that has spread to other more distant organs, such as the lungs, liver, bones, and brain, or to lymph nodes outside the abdomen (National Wilms Tumor Study Group Staging System)


Poorly Differentiated Neuroblastoma

A neuroblastoma in which the differentiating neuroblasts constitute less than five-percent of the tumor cells.


Childhood Ewing Sarcoma

A Ewing sarcoma that occurs during childhood.


Skin Ewing Sarcoma

A rare Ewing sarcoma that arises from the skin.


Recurrent Atypical Teratoid/Rhabdoid Tumor

The reemergence of an atypical teratoid/rhabdoid tumor after a period of remission.


Stage M0 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

No visible disease on imaging (MRI brain and spine) beyond primary site of disease and no tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Atypical Teratoid/Rhabdoid Tumor Molecular Subtypes

A term that refers to the classification of atypical teratoid/rhabdoid tumors according to their molecular characteristics.


Unresectable Chordoma

A chordoma which is not amenable to surgical resection.


Ciliary Body Teratoid Medulloepithelioma

A rare, unilateral, benign or malignant embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium and contains heterologous elements, particularly cartilage, skeletal muscle, and brain tissue.


Undifferentiated Neuroblastoma

A neuroblastoma characterized by the absence of differentiating neuroblasts.


Childhood Medulloblastoma by Toronto Guidelines v2 Stage, Tier 2

A term that refers to the staging of childhood medulloblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2.