Stage II Ampulla of Vater Cancer AJCC v8

Stage II includes: IIA: T3a, N0, M0; IIB: T3b, N0, M0. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Germinative Follicular Epithelium Neoplasm

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A neoplasm involving the germinative follicular epithelium.


Tremor, CTCAE 3.0

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Infectious disease of genitourinary system

An acute or chronic infectious process affecting any part of the genitourinary system.


Grade 1 Urinary Electrolyte Wasting, CTCAE


Myeloid/Lymphoid Neoplasms with ETV6-ABL1

Hematologic neoplasms characterized by t(9;12)(q34.1;p13.2) that results in ETV6-ABL1 gene fusion. They have clinicopathological features of chronic myeloid leukemia with frequent eosinophilia.


Grade 4 Pancreatic Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Mixed Failure to Thrive

Failure to thrive due to both organic and non-organic causes.


Dysgeusia, CTCAE

A disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell.


Grade 1 Urinary Tract NOS Intra-Operative Injury, CTCAE


PSA Level Finding

A finding that indicates the amount of prostate specific antigen in a sample.


Wound Complication, CTCAE

A finding of development of a new problem at the site of an existing wound.


Grade 5 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Fever Without Neutropenia, CTCAE


Grade 1 Dry Skin, CTCAE

Covering <10% BSA and no associated erythema or pruritus


Childhood Malignant Digestive System Neoplasm

A malignant neoplasm that affects any part of the digestive system and occurs during childhood.


Stage IV Lentigo Maligna Melanoma AJCC v6 and v7

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


Grade 1 Other Growth and Development, CTCAE


Pediatric Infectious Disorder

An infectious disorder that occurs during infancy, childhood, or adolescence.


Hypothalamic Cancer

A primary or metastatic malignant neoplasm that affects the hypothalamus.


Hypergranular promyelocytic leukemia

Acute Promyelocytic leukemia characterized by the presence of hypergranular promyelocytes and characteristic cells that contain bundles of Auer rods.


Grade 2 Oropharyngeal Pain, CTCAE

Moderate pain; altered oral intake; non-narcotics initiated; topical analgesics initiated


Grade 4 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Cholesterol High, CTCAE

>500 mg/dL; >12.92 mmol/L


Grade 1 Pulmonary Valve Disease, CTCAE

Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging


Primary cutaneous CD30 antigen positive T-cell lymphoproliferative disorder

A spectrum of lymphoproliferative disorders characterized by CD30 (Ki-1)-positive cutaneous T-cell infiltrates. The two ends of the spectrum include lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma.


Non-Hodgkin's Lymphoma, Lymphoblastic (WF)


Grade 3 Intraoperative Hepatobiliary Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 5 Cystitis Noninfective, CTCAE

Death


Solder Fume Exposure

Environmental, occupational, or consumer-based exposure to vaporized materials during the soldering process.


Grade 4 Prolapse of Gastrointestinal Stoma, CTCAE


Stage IVB Gallbladder Cancer AJCC v8

Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1). N2: Metastases to four or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Grade 2 Esophagus Intra-Operative Injury, CTCAE


Dyspnea with Moderate Physical Activity

Dyspnea experienced during moderate exertion.


Localized Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

An undifferentiated high grade pleomorphic sarcoma of bone that occurs in childhood and has not spread to other anatomic sites.


Grade 3 Hematuria, CTCAE

Gross hematuria; transfusion, IV medications, or hospitalization indicated; elective invasive intervention indicated; limiting self care ADL


Grade 1 Fall, CTCAE

Minor with no resultant injuries; intervention not indicated


Locally Advanced Pancreatic Neuroendocrine Carcinoma

A pancreatic neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Nodal or Junctional Rhythm, CTCAE


Grade 3 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Yolk Sac Tumor with Somatic-Type Malignancy

A yolk sac tumor that is characterized by morphologic transformation to somatic-type malignancy. The somatic-type malignant component most often is sarcomatous or carcinomatous.


Grade 4 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intraepithelial Melanocytic Hyperplasia

A hyperplasia of the intraepithelial melanocytes.


Grade 1 Stomach Stricture or Stenosis, CTCAE


FIGO Stage IVC Gestational Trophoblastic Tumor


Childhood Gastric Carcinoma

A rare carcinoma of the stomach that occurs during childhood.


Phlebitis Including Superficial Thrombosis, CTCAE


Grade 2 Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Superior Vena Cava Syndrome, CTCAE

Severe symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting)


Stage IV Gallbladder Cancer AJCC v6

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.)


Stage y-I Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

Tumor limited to kidney and completely resected. Renal capsule may be infiltrated by tumor, but tumor does not reach the outer surface. Tumor may protrude or bulge into the pelvic system or ureter but does not infiltrate. Vessel of renal sinus not involved. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 3 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Native valve endocarditis

Endocarditis affecting a native valve of the heart.


Benign germ cell neoplasm

A germ cell tumor without evidence of atypia and metastatic potential.


Pleural Infection

An infectious process affecting the pleura.


Stage II Uterine Corpus Cancer

Stage II includes: T2, N0, M0.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  Endocervical glandular involvement only should be considered as Stage I and not as Stage II.  N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Esophageal Hodgkin Lymphoma

A very rare Hodgkin lymphoma that arises from the esophagus.


Refractory Vaginal Carcinoma

Vaginal carcinoma that does not respond to treatment.


Grade 4 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Grade 2 Hypoxia, CTCAE

Decreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen


Verumontanum Mucosal Gland Hyperplasia

A benign microacinar proliferation occurring exclusively in the verumontanum and adjacent posterior urethra where the ejaculatory ducts and utricle empty into the urethra. Crystalloids and intraluminal mucin are usually absent, but; intraluminal corpora amylacea are often present. The lining epithelium typically consists of bland cuboidal to columnar luminal cells with underlying basal cells.


Unresectable Fallopian Tube Endometrioid Adenocarcinoma

Fallopian tube endometrioid adenocarcinoma that is not amenable to surgical resection.


Grade 2 Genitourinary Stoma Prolapse, CTCAE


Acute Myeloid Leukemia with t(1;17)(q42.3;q21.2); IRF2BP2-RARA

Acute myeloid leukemia with variant RARA rearrangement associated with t(1;17)(q42.3;q21.2) resulting in IRF2BP2-RARA fusion protein expression.


Salivary Gland Infection, CTCAE

A disorder characterized by an infectious process involving the salivary gland.


Grade 3 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pelvis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Vascular Access Graft Failure

Failure to achieve vascular access due to damage of the graft that was created for this purpose.


Grade 1 Muscle Weakness Right-Sided, CTCAE

Symptomatic; perceived by patient but not evident on physical exam


Anal Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the anal region.


Grade 1 Upper Extremity Artery Injury, CTCAE


Retinal Vascular Disorder, CTCAE

A disorder characterized by pathological retinal blood vessels that adversely affects vision.


Recurrent Adult Diffuse Large Cell Lymphoma

The reemergence of adult diffuse large cell lymphoma after a period of remission.


Grade 1 Transient Ischemic Attacks, CTCAE

Mild neurologic deficit with or without imaging confirmation


Benign Anal Granular Cell Tumor

A granular cell tumor that arises from the anus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 4 Vision Decreased, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Acquired Facial Nerve Palsy

A condition characterized by reduced or absent movement of the ipsilateral face as a consequence of an injury to the seventh cranial nerve that has occurred after birth.


Grade 5 Pulmonary Edema, CTCAE

Death


Unresectable Fibrosarcoma

A fibrosarcoma that is not amenable to surgical resection.


Central line complication

A problem with a central venous access catheter or site of insertion.


Grade 4 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Urinary Tract Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the urinary tract.


Beta Thalassemia Plus Structural Variants

A heterozygous state in which a person has a mutation in a beta globin allele causing beta thalassemia, together with other structural variants in the other allele.


Esthesioneurocytoma

A rare benign neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity. Microscopically, it is characterized by the absence of malignant characteristics and the absence of rosettes formation.


Small Intestinal Mucositis, CTCAE

A disorder characterized by ulceration or inflammation of the mucous membrane of the small intestine.


Recurrent Primary Amyloidosis

The reemergence of primary amyloidosis after a period of remission.


Metastatic transitional cell carcinoma

A carcinoma that arises from transitional cells and has spread from its original site of growth to another anatomic site.


Grade 3 Radiation Recall Reaction (Dermatologic), CTCAE

Moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion


Grade 2 Esophageal Varices Hemorrhage, CTCAE

Self-limited; intervention not indicated


Asystole, CTCAE 5.0

A disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart.


Grade 3 Apnea, CTCAE

Present; medical intervention indicated


Neonatal Gastrointestinal Bleeding, AE

An adverse event in a newborn characterized by hemorrhage originating at any site located within the gastrointestinal tract.


Localized Childhood Malignant Bone Neoplasm by Toronto Guidelines v2

Tumor confined to the area of origin including the regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 2 Neuroendocrine ADH Secretion Abnormality, CTCAE


Grade 2 Blood Antidiuretic Hormone Abnormal, CTCAE

Symptomatic; medical intervention indicated


Solvent Exposure

Environmental, occupational, or consumer-based exposure to volatiles associated with production, handling and use of chemical solvents.


Non-Neoplastic Peritoneal Disorder

A non-neoplastic disorder that affects the peritoneum. Representative examples include peritonitis and panniculitis.


Inherited neuropathies

A hereditary disorder that affects the sensory and/or motor nerves or the autonomic nerves.


Grade 2 Thoracic Duct Intra-Operative Injury, CTCAE


Skin Reaction Secondary to Radiation Therapy


Intracranial Laceration Related to Birth

Tearing of the cerebral or cerebellar parenchyma or vessels of a newborn infant due to forces occurring during labor and delivery.


Grade 1 Hypernatremia, CTCAE

>ULN-150 mmol/L


Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8

Stage IIIA includes: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Grade 1 Pituitary Intra-Operative Injury, CTCAE


Grade 3 Pancreatic Enzymes Decreased, CTCAE

Sequelae of absorption deficiency


Grade 3 Esophagitis, CTCAE

Severely altered eating/swallowing; tube feeding, TPN, or hospitalization indicated


Fracture, CTCAE

A finding of traumatic injury to the bone in which the continuity of the bone is broken.


Grade 1 Intraoperative Musculoskeletal Injury, CTCAE

Primary repair of injured organ/structure indicated


Tumor Mass of the Extremity

A mass-forming benign or malignant neoplasm that affects a limb of the body.


Esophageal Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The Ki-67 index is higher than 20%.


Grade 2 Tendon Intra-Operative Injury, CTCAE


Grade 1 Female Genital Tract Fistula, CTCAE


Grade 1 Pleural Hemorrhage, CTCAE

Asymptomatic; mild hemorrhage confirmed by thoracentesis


Advanced Malignant Germ Cell Tumor

A malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Endometrial Carcinoma

Endometrial carcinoma that is not amenable to surgical resection.


intraductal papillary-mucinous neoplasm of pancreas with moderate dysplasia

A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that exhibit nuclear stratification, loss of polarity, and crowding.  There is moderate nuclear hyperchromasia.


Aplastic anemia due to infection

Aplastic anemia caused by an infection.


Grade 3 Keratitis, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); corneal ulcer; limiting self care ADL


Otitis Media, CTCAE

A disorder characterized by an infectious process involving the middle ear.


Grade 5 Neonatal Fever, AE

A febrile adverse event in a newborn which results in death.


Schizoaffective disorder, depressive type

Schizoaffective disorder with episodes of depression only.


Grade 2 Rectal Obstruction, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Esophageal High Grade Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal mucosa.  It includes lesions termed moderate dysplasia, and carcinoma in situ (severe dysplasia).  (WHO, 2000)


Grade 4 Vasculitis, CTCAE

Life-threatening consequences; evidence of peripheral or visceral ischemia; urgent intervention indicated


Advanced Primary Malignant Brain Neoplasm

A malignant neoplasm that arises from the brain and has spread extensively or is no longer responding to treatment.


Stage IIIB Fallopian Tube Cancer AJCC v7

Stage IIIB includes: T3b, N0, M0.  T3b: Macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Ileal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 CNS Cerebrovascular Ischemia, CTCAE


Pathologic Stage I Esophageal Adenocarcinoma AJCC v8

Stage I includes: IA: (T1a, N0, M0, G1); (T1a, N0, M0, GX); IB: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX); IC: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Neoplasm by Special Category

A neoplasm defined by its unique characteristic as they apply to clinical presentation and course, morphologic patterns, frequency, and/or age distribution.


Grade 3 Laryngeal Edema, CTCAE

Stridor; respiratory distress; hospitalization indicated


Grade 5 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Upper Gastrointestinal Hemorrhage, CTCAE

A disorder characterized by bleeding from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach).


Grade 3 Superior Vena Cava Vein Injury, CTCAE


Vomiting, CTCAE

A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth.


Grade 2 International Normalized Ratio of Prothrombin Time, CTCAE


Grade 4 Colonic Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Hypoalbuminemia, CTCAE

<3-2 g/dL; <30-20 g/L


Localized Gastric Carcinoma

A carcinoma that arises from the stomach and has not spread to other anatomic sites.


Uterine Ligament Wolffian Tumor

An epithelial neoplasm of Wolffian (mesonephric) origin arising from a uterine ligament. Most tumors behave in a benign fashion.


Grade 5 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Retrobulbar Hemorrhage

Bleeding in the orbital cavity that results in compression of orbital structures, resulting in ischemia of the optic nerve, and possible loss of vision.


Grade 1 Aspiration, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Transient Hyperinsulinism

Hyperinsulinism that resolves spontaneously. This is the most common cause of neonatal hypoglycemia.


Recurrent Malignant Solid Neoplasm

A malignant solid neoplasm that has recurred after a period of remission.


Chronic Decubitus

A longstanding lesion caused by death of tissue due to external pressure.


Sinusoidal hemangioma

A rare hemangioma occurring mainly in middle-aged adults. The most common location is in the trunk. The lesions are small, asymptomatic, and bluish. They are composed of irregular, dilated, congested thin-walled vascular channels with scant smooth muscle in a sinusoidal or sieve-like pattern. (WHO 2018)


Stage IB Cervical Cancer AJCC v9

Stage IB includes: T1b, N0, M0. T1b: Tumor with measured deepest invasion more than 5 mm (greater than FIGO stage IA); lesion limited to the cervix uteri with size measured by maximum tumor diameter. Note: The involvement of vascular/lymphatic spaces should not change the staging. The lateral extent of the lesion is no longer considered. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Febrile Neutropenia without Clinically or Microbiologically Documented Infection with Absolute Neutrophil Count Less Than 1 X 10e9 per Liter and Temperature Greater Than or Equal to 38 Point 5 Degrees Celsius, CTCAE


Grade 3 Atrial Fibrillation, CTCAE

Symptomatic, urgent intervention indicated; device (e.g., pacemaker); ablation; new onset


Grade 1 Cervical Spine Range of Motion, CTCAE


General Disorders and Administration Site Conditions - Other, Specify, CTCAE


Stage IVB Cervical Cancer AJCC v6 and v7

Stage IVB includes: Any T, Any N, MI. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Stage IIIC Gastric Cancer AJCC v7

Stage IIIC includes: (T4b, N2, M0); (T4b, N3, M0); (T4a, N3, M0).  T4a: Tumor invades serosa (visceral peritoneum).  T4b: Tumor invades adjacent structures. N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Killing Pain

A sensation of extreme discomfort and anguish that is perceived as severe enough to cause one's death.


Grade 2 Stoma Pulmonary Hemorrhage, CTCAE


Grade 2 Other Musculoskeletal and Soft Tissue, CTCAE


Metastatic Pancreatic Ductal Adenocarcinoma

An adenocarcinoma that arises from the exocrine pancreatic ducts and has metastasized to other anatomic sites.


Grade 1 Bullous Dermatitis, CTCAE

Asymptomatic; blisters covering <10% BSA


Grade 2 Glossopharyngeal Nerve Disorder, CTCAE

Moderate symptoms; limiting instrumental ADL


CTCAE v4 Grade 2

An adverse event for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated; or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances).


Hematologic Malignancy-Associated Skin Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the skin in a patient with a history of hematologic malignancy, usually non-Hodgkin lymphoma or chronic lymphocytic leukemia.


Marginal ulcer

An ulcer that develops in the jejunal mucosa close to the anastomosis site following a gastroenterostomy procedure.


Metastatic Carcinoma to the Uterine Cervix

A carcinoma that has spread to the cervix from another anatomic site.


Conjunctival foreign body

External material in or on the conjunctiva.


Gum Infection, CTCAE

A disorder characterized by an infectious process involving the gums.


A high grade poorly differentiated carcinoma arising from the digestive system.  It is composed of small or large neoplastic cells that express immunohistochemical evidence of neuroendocrine differentiation.  There is marked nuclear atypia, necrosis, and more than 20 mitoses per 10 HPF.


Low Glutathione Level

An indication that a lower than average level of glutathione was detected in a sample.


Grade 2 Intraoperative Endocrine Injury, CTCAE

Partial resection of injured organ/structure indicated


Nevus of Female Genitalia

A nevus that arises from the female genital organs. This category includes congenital nevus, acquired nevus, dysplastic nevus, blue nevus, and atypical melanocytic nevus of the genital type.


Increased Porphyrin

Increase in the amount of porphyrin.


Metabolic or Respiratory Acidosis, CTCAE


Grade 5 Hypertriglyceridemia, CTCAE

Death


Acute Myocardial Injury with Type I Myocardial Infarction Related to COVID-19

Acute myocardial injury with clinical presentation suggestive of type I myocardial infarction with detection of a rise or fall of cardiac troponin values with at least one value above the 99th percentile upper reference limit and with at least 1 of the following: 1. Symptoms of acute myocardial ischemia; 2. New ischemic ECG changes; 3. Development of pathological Q waves; 4. Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology; 5. Identification of a coronary thrombus by angiography including intracoronary imaging or by autopsy, occurring in a patient with probable or confirmed acute COVID-19.


Intraepithelial neoplasia of the penis or vulva. It usually presents as a solitary white or pink macule or plaque that may be slightly elevated. A background of long-standing lichen sclerosus is often present.


Grade 3 Upper Extremity Artery Intra-Operative Injury, CTCAE


Ectromelia

A congenital defect characterized by the absence or hypoplasia of one or more extremities.


Grade 3 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 5 Pancreas Infection, CTCAE

Death


Grade 5 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute Bacterial Prostatitis

An acute infection of the prostate gland caused by bacteria, most often Escherichia coli, Proteus mirabilis, Klebsiella, and Pseudomonas aeruginosa. Signs and symptoms include fever, lower back pain, urinary frequency, and painful urination.  The urinalysis reveals the presence of white cells.  Risk factors include intraprostatic ductal reflux, phimosis, urinary tract infections, and unprotected anal intercourse.


Postoperative Hemorrhage, CTCAE

A disorder characterized by bleeding occurring after a surgical procedure.


Grade 3 Neck Edema, CTCAE

Generalized neck edema (e.g., difficulty in turning neck); limiting self care ADL


Grade 5 Bile Duct Stenosis, CTCAE

Death


Stage IIIC1 Uterine Corpus Cancer AJCC v8

Stage IIIC1 includes: T1-T3, N1/N1mi/N1a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


Breast Nipple and Areolar Deformity, CTCAE


Refractory Malignant Neoplasm of Multiple Primary Sites

Malignant neoplasm of multiple primary sites that is resistant to treatment.


Grade 2 Vagina Stricture or Stenosis, CTCAE


Urethral Melanoma

A rare melanoma that arises from the urethral mucosa.


Grade 3 Vein Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Anus Intra-Operative Injury, CTCAE


Refractory Invasive Pulmonary Aspergillosis

Invasive pulmonary aspergillosis that is resistant to treatment.


Thoracotomy Scar

Replacement of destroyed tissue by fibrous tissue due to a surgical procedure where an incision was made into the chest wall to the left or to the right of the midline.


Pharyngeal Stenosis, CTCAE

A disorder characterized by a narrowing of the pharyngeal airway.


Grade 3 Pulmonary Fibrosis Radiographic Changes, CTCAE


Grade 5 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


P2 Hydronephrosis

Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is greater than or equal to 15 mm, 2) the calyces may be dilated centrally and peripherally, 3) or a dilated ureter is visible, 4) the parenchymal thickness and appearance is normal, and 5) the bladder is normal. Cases in which there is peripheral calyceal dilation but the APRPD is less than 15 mm are classified as UTD P2. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Prostatic Intraepithelial Neoplasia-Like Adenocarcinoma

A rare subtype of prostate acinar adenocarcinoma that morphologically resembles high-grade prostatic intraepithelial neoplasia. It is characterized by the presence of large malignant glands lined with pseudostratified epithelium. It is graded as Gleason score 3+3=6.


Resectable Malignant Female Reproductive System Neoplasm

A malignant female reproductive system neoplasm that is amenable to surgical resection.


Skin Atrophy, CTCAE 5.0

A disorder characterized by the degeneration and thinning of the epidermis and dermis.


Stage I Gastric Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Cervical Mesonephric Remnants and Hyperplasia

The presence of embryonic remnants of mesonephric ducts in the cervix and their benign hyperplastic proliferations.


Grade 3 Uveitis, CTCAE

Anterior uveitis with 3+ or greater cells; intermediate posterior or pan-uveitis


Glucagonoma, malignant

A glucagon-producing neuroendocrine tumor arising from the alpha cells of the pancreas.  It may be associated with necrolytic erythema migrans, diarrhea, diabetes, glossitis, weight loss, malabsorption, and anemia.  It displays vascular invasion and metastasizes to other anatomic sites.


Benign Osteoclastic Giant Cell-Rich Tumor of Bone

A giant cell tumor that arises from the bone and is characterized by the absence of local aggression and lack of metastatic potential.


Neonatal rickets

Rickets that usually affects premature infants. Factors that contribute to the development of neonatal rickets include calcium, phosphorus, or calciferol deficiency. It manifests with spontaneous fractures, respiratory distress, and growth developmental delays.


Unresectable Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma that is not amenable to surgical resection.


Grade 2 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


Recurrent Plasma Cell Neoplasm

The reemergence of a plasma cell neoplasm after a period of remission.


Prostate Paraganglioma

A paraganglioma that affects the prostate gland.


Anxiety, CTCAE 5.0

A disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.


Adenoma of the Retinal Pigment Epithelium

A benign neoplasm that arises from the retinal pigment epithelium. It consists of cords and tubules of variably pigmented proliferating retinal pigment epithelium cells, separated by fibrous stroma. Malignant transformation is rare. (WHO 2018)


Neonatal Herpes Simplex Infection

Infection in the first month of life caused by the Herpes simplex virus.


Grade 2 Esophageal Infection, CTCAE

Local intervention indicated (e.g., oral antibiotic, antifungal, antiviral)


Grade 3 Other Allergy and Immunology, CTCAE


Grade 2 Movements Involuntary, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 4 Pelvis NOS Intra-Operative Injury, CTCAE


Low Grade Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Grade 1 Nail Ridging, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Neuroendocrine carcinoma of the bladder

A malignant, high grade neuroendocrine neoplasm that arises from the bladder. This category includes small cell and large cell neuroendocrine carcinoma.


Grade 3 Urostomy Obstruction, CTCAE

Altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); elective operative intervention indicated


Grade 1 Urinary Retention, CTCAE

Urinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual


Grade 1 Upper Extremity Vein Intra-Operative Injury, CTCAE


Drug Resistant Epilepsy

Epilepsy that is refractory to treatment.


Grade 1 Bronchopulmonary Dysplasia, AE

An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND breathing room air at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; breathing room air by 56 days postnatal age in infants born greater than 32 weeks' gestation; breathing room air at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


Stage IIIC Esophageal Adenocarcinoma AJCC v7

Stage IIIC includes: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent WHO Grade 3 Glioma

The reemergence of a WHO grade III glioma after a period of remission.


Advanced Adenoid Cystic Carcinoma

Adenoid cystic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 5 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Lacrimal Drainage System Lymphoepithelial Carcinoma

A rare nonkeratinizing squamous cell carcinoma that arises from the lacrimal sac or nasolacrimal duct. It is characterized by the presence of large cells with vesicular nuclei and prominent nucleoli, a syncytial growth pattern, and a lymphoplasmacytic infiltrate.


Thrombosis of abdominal aorta

Formation of blood clot in the lumen of the abdominal aorta. It may lead to severe abdominal pain and ischemic necrosis of the intestine.


Grade 2 Breast Infection, CTCAE

Local infection with moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage IIIA Cervical Cancer FIGO 2018

Cervical carcinoma that involves the lower third of the vagina, with no extension to the pelvic wall. (FIGO 2018)


Facial Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the facial nerve (seventh cranial nerve).


Grade 5 Bronchopulmonary Dysplasia, AE

A bronchopulmonary dysplasia adverse event in a newborn which results in death.


Acquired factor IX deficiency disease

An acquired coagulation disorder characterized by the partial or complete absence of factor IX activity in the blood.


Grade 3 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Life Threatening Adverse Event

An adverse event that has life-threatening consequences; for which urgent intervention is indicated; that puts the patient at risk of death at the time of the event if immediate intervention is not undertaken.


Burn, CTCAE

A finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment.


Refractory Fallopian Tube Adenocarcinoma

Fallopian tube adenocarcinoma that is resistant to treatment.


Grade 3 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Splenic Hamartoma

A rare hamartoma that arises from the spleen. The majority of cases are incidental findings in splenectomy specimens or during autopsy.


Grade 4 Pancreatic Duct Intra-Operative Injury, CTCAE


Grade 4 Carbon Monoxide Diffusion Capacity, CTCAE


Recurrent Childhood Fibrillary Astrocytoma

The reemergence of fibrillary astrocytoma in childhood after a period of remission.


Recurrent Pineal Parenchymal Cell Neoplasm

The reemergence of pineal parenchymal cell neoplasm after a period of remission.


Vagus Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the vagus nerve (tenth cranial nerve).


Grade 3 Social Circumstances - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Gallbladder Pain, CTCAE

Mild pain


Ureteric fistula

An abnormal communication between the ureter and another organ or anatomic site.


Grade 1 Anus Intra-Operative Injury, CTCAE


Grade 4 Stridor, CTCAE

Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Grade 2 Hepatitis B Reactivation, CTCAE

Moderate symptoms; medical intervention indicated


Grade 1 Shingles, CTCAE

Localized, local intervention indicated


Cardiac Enzyme Elevation

An increase from the normal levels of cardiac enzymes measurement.


Grade 2 Meninges Intra-Operative Injury, CTCAE


Broad Ligament Serous Cystadenofibroma

A rare serous cystadenofibroma arising from the broad ligament.


Grade 2 Colonic Obstruction, CTCAE

Symptomatic; altered GI function


Grade 2 Amnesia, CTCAE

Moderate; short term memory loss; limiting instrumental ADL


FNCLCC Sarcoma Grade 3

A sarcoma with a total score of 6 or higher according to the FNCLCC guidelines.


Grade 3 Arterial Injury, CTCAE

Severe symptoms; limiting self care ADL; repair or revision indicated


Grade 3 Esophageal Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated; limiting self care ADL


Male Reproductive System Precancerous Condition

A premalignant pathologic process arising from an organ of the male reproductive system.  It is characterized by cellular atypia and/or dysplasia but does not show morphologic evidence of stromal invasion at the time of diagnosis.  Representative examples include prostatic intraepithelial neoplasia, giant condyloma acuminatum of the penis, and penile intraepithelial neoplasia.


Grade 1 Dermatitis Radiation, CTCAE

Faint erythema or dry desquamation


Grade 1 Jejunal Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Unresectable Ampulla of Vater Adenocarcinoma

Adenocarcinoma that arises from the ampulla of Vater and is not amenable to surgical resection.


Metastatic Bone Sarcoma

Bone sarcoma that has spread from the original site of growth to another anatomic site.


Hepatic Failure, CTCAE

A disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, alkaline phosphatase, aminotransferase, and/or prolongation of prothrombin time (INR.) Drug-induced liever injury (DILI) as defined by Hy's Law.


BAP1-Inactivated Skin Melanocytic Neoplasm

A group of cutaneous melanocytic neoplasms that includes the combined BAP1-inactivated nevus and the BAP1-inactivated melanocytoma.


Hyperplasia of Brunner glands of duodenum

A rare hyperplastic lesion of Brunner's gland in the duodenum. Although it is usually asymptomatic and discovered incidentally during upper gastrointestinal endoscopy, it may cause hemorrhage.


Grade 1 Testis Intra-Operative Injury, CTCAE


Grade 2 Pleural Effusion, CTCAE

Symptomatic; intervention indicated (e.g., diuretics or therapeutic thoracentesis)


Stage IVA Oral Cavity Verrucous Carcinoma


B-Cell Proliferation of Uncertain Malignant Potential

A B-cell lymphoproliferative disorder with uncertain malignant potential. The representative example of this category is lymphomatoid granulomatosis.


Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Vulvar Carcinoma

Vulvar carcinoma that does not respond to treatment.


Grade 3 Cataract, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Premature Delivery, CTCAE

A disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation.


Grade 3 Sleep Apnea, CTCAE

Oxygen desaturation; associated with pulmonary hypertension; medical intervention indicated; limiting self care ADL


Grade 1 Bronchopulmonary Hemorrhage NOS, CTCAE


Grade 5 Lymph Leakage, CTCAE

Death


Grade 2 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 3 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Appendicitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Foreign-Body Reaction

An inflammatory lesion comprised of epithelioid histiocytes and chronic inflammation that is caused by the presence of extraneous material.


Non-Neoplastic Musculoskeletal Disorder

A non-neoplastic disorder that affects muscles and bones.


Grade 3 Pharynx Obstruction and Stenosis, CTCAE


Grade 2 Blood Bilirubin Increased, CTCAE

>1.5-3.0 x ULN if baseline was normal; >1.5-3.0 x baseline if baseline was abnormal


lymphomatoid papulosis, type C

A variant of lymphomatoid papulosis characterized clinically by regressing skin papules, and morphologically by features resembling anaplastic large cell lymphoma.


Ovarian or testicular dysfunction associated with high levels of gonadotropins, that is present at birth.


Recurrent Ampulla of Vater Adenocarcinoma

The reemergence of ampulla of Vater adenocarcinoma after a period of remission.


Maternal Weight Gain in Pregnancy

The last recorded maternal weight prior to birth minus the last recorded weight immediately prior to pregnancy. (reVITALize)


Congenital Cystic Hygroma

A congenital lymphatic malformation usually arising from the neck and characterized by cystic dilation of the lymphatic vessels.


Adenocarcinoma endometrial metastatic

An adenocarcinoma which originated in the endometrium and has spread to another anatomic site.


Seminal Versicle Carcinoma

A carcinoma that arises from the seminal vesicle.


Refractory Acute Myeloid Leukemia Not Otherwise Specified

Acute myeloid leukemia not otherwise specified that does not respond to treatment.


Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder

The reemergence of monomorphic post-transplant lymphoproliferative disorder after a period of remission.


Grade 5 Splenic Infection, CTCAE

Death


An exceedingly rare adenocarcinoma that arises from the endometrium and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Grade 1 Flatulence, CTCAE

Mild symptoms; intervention not indicated


Stage IB Gastric Carcinoma

Stage IB includes: (T2, N0, M0); (T1, N1, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Appendicitis Perforated, CTCAE

A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.


Grade 3 Prolapse of Intestinal Stoma, CTCAE

Severe symptoms; elective operative intervention indicated; limiting self care ADL


Female urinary-genital tract fistula

An abnormal connection between the urinary system and the genitals in a female.


Grade 3 Lymph Node Pain, CTCAE

Severe pain; limiting self care ADL


Primary Malignant Pelvic Neoplasm

A malignant neoplasm that arises from the organs and structures of the pelvis.


Grade 2 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Severe Cardiac Valve Regurgitation

Evidence of severe retrograde blood flow through the valve(s) of the heart. (ACC)


FIGO Grade 1 Endometrial Mucinous Adenocarcinoma

A primary mucinous adenocarcinoma of the endometrium that contains equal to or less than 5% non-squamous solid areas.


Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Gallbladder Intra-Operative Injury, CTCAE


Grade 5 Middle Ear Inflammation, CTCAE

Death


Mixed Cellularity Classic Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for mixed cellularity classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Grade 4 Gallbladder Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Breast Atrophy, CTCAE

Minimal asymmetry; minimal atrophy


Grade 3 Bladder Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Stage III Urethral Cancer AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0). T1: For male penile urethra and female urethra: Tumor invades subepithelial connective tissue. For prostatic urethra: Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. T3: For male penile urethra and female urethra: Tumor invades any of the following: corpus cavernosum, anterior vagina. For prostatic urethra: Tumor invades the periprostatic fat. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IIIA Appendix Carcinoma AJCC v8

Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


clear cell adenocarcinoma of gallbladder

A rare morphologic variant of gallbladder adenocarcinoma composed of malignant glandular epithelium with a predominance of glycogen rich clear cells.  The cells display hyperchromic nuclei and well-defined cytoplasmic borders.


Nervous System Disorders - Other, Specify, CTCAE


Chronic inflammation

An inflammatory process characterized by the presence of lymphocytes and plasma cells and the absence of polymorphonuclear neutrophils.


Fetal Neurodevelopmental Disorder

A fetal affliction that has a neurological basis and manifests as a developmental disability.


Grade 3 Colonic Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Recurrent Anaplastic Astrocytoma

The reemergence of anaplastic astrocytoma after a period of remission.


Grade 4 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


Grade 5 Neonatal Respiratory Insufficiency, AE

A respiratory insufficiency adverse event in a newborn which results in death.


Miserable Pain

A sensation of discomfort or distress that renders an individual unable to find any happiness.


Grade 3 Bullous Dermatitis, CTCAE

Blisters covering >30% BSA; limiting self care ADL


Stage I Vulvar Cancer

Stage I includes: T1, N0, M0. T1: Invasive vulvar cancer confined to the vulva or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 5 Vagus Nerve Disorder, CTCAE

Death


T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta

An uncommon variant of T-cell large granular lymphocyte leukemia expressing the gamma-delta T-cell receptor. Approximately 60% of these cases are CD8-positive and the remainder are CD4/CD8-negative.


Unresectable Low Grade Glioma

Low grade glioma that is not amenable to surgical removal.


trauma to the abdomen

Trauma to the abdomen.


Gastrointestinal Perforation, CTCAE

An adverse event marked by rupture in the wall of a structure of the gastrointestinal system.


Stage III Bone Cancer AJCC v8

Stage III includes: T3, N0, M0, G2 or G3. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Grade 2 Colon Intra-Operative Injury, CTCAE


Radiating Chest Pain Along Right Middle Sternal Border

The location of the radiating chest pain is along the right middle sternal border.


Pancreatic Enzymes Decreased

A laboratory test result which indicates decreased levels of pancreatic enzymes in a biologic specimen.


Grade 1 Upper Extremity Intra-Operative Injury, CTCAE


Nevoid Melanoma

A rare variant of cutaneous melanoma occurring mostly in adults in their fifth decade. Morphologically it resembles an ordinary compound or dermal nevus.


Stage I Bone Cancer AJCC v7

Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 1 Leukoencephalopathy Radiographic Findings, CTCAE


Metastatic malignant neoplasm to retina

A malignant neoplasm that has spread to the retina from another anatomic site.


Stage IVB Uterine Corpus Cancer AJCC v7

Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone.  It excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa). This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Stage IB3 Cervical Cancer FIGO 2018

Invasive cervical carcinoma equal or more than 4 cm in greatest dimension. (FIGO 2018)


Cutaneous Mature B-Cell Neoplasm

A B-cell neoplasm that arises from the skin.


Grade 3 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Prostate Melanoma

An exceptionally rare melanoma arising from the prostate gland.


Grade 3 Retinal Vascular Disorder, CTCAE

Retinal vascular disorder with neovascularization


Deep Lipoma

A benign well-circumscribed tumor, composed of mature adipocytes, that arises within deep soft tissues.


Craniofacial Fibrous Dysplasia

Fibrous dysplasia affecting the craniofacial bones.


Grade 5 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Muscular and Skeletal Hypoplasia, CTCAE


Grade 2 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cardiac granuloma

A granuloma located in the myocardium.


Stage III Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

Residual tumor or nonhematogenous metastases confined to abdomen. Involved abdominal nodes. Peritoneal contamination or tumor implant. Tumor spillage of any degree occurring before or during surgery. Gross residual tumor in abdomen. Biopsy of tumor (including fine-needle aspiration) prior to removal of kidney. Resection margins involved by tumor. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 3 Pancreatic Duct Intra-Operative Injury, CTCAE


Grade 2 Proctitis, CTCAE

Symptomatic (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental ADL


Persistent Pulmonary Hypertension of the Newborn, AE

An adverse event in a newborn characterized by elevated pulmonary vascular pressure in a neonate.


Grade 5 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Elevated DKK1

A finding indicating elevated concentrations of DKK1 in a sample.


Grade 5 Cecal Infection, CTCAE

Death


childhood round cell sarcoma with EWSR1-non-ETS fusion

A round cell sarcoma with EWSR1-non-ETS fusion that occurs during childhood.


Neonatal Spell

Cardiorespiratory events that are characterized by variable combinations of cessation of breathing, decrease in blood oxygen saturation, and decreased heart rate.


Stage IIA Esophagus Carcinoma

Stage IIA includes: For squamous cell carcinoma: (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X).  For adenocarcinoma: (T2, N0, M0, G3).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Grade 4 Ovary Intra-Operative Injury, CTCAE


Mucositis and Stomatitis by Functional and Symptomatic Classification, CTCAE


Leukopenia neonatal

Leukopenia that occurs in the neonatal period.


Acute lymphoblastic leukemia recurrent

The reemergence of acute lymphoblastic leukemia after a period of remission.


Unresectable Small Cell Neuroendocrine Carcinoma

Small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Pancreatic intraepithelial neoplasia

A pre-cancerous, non-invasive pancreatic epithelial neoplasm that arises from and is confined to the pancreatic ducts.  It is a papillary or flat neoplasm that usually measures less than 5 mm in diameter.


Esophageal Cancer by AJCC v8 Stage

A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 8th edition.


Stage IIIB Merkel Cell Carcinoma AJCC v7

Stage IIIB includes: Any T, N1b/N2, M0.  N1b: Macrometastasis in regional lymph nodes.  N2: In transit metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Recurrent Myeloproliferative Neoplasm

The reemergence of a myeloproliferative neoplasm after a period of remission.


Burn of axilla

A traumatic injury to the axilla resulting from exposure to caustic chemicals, extreme heat, extreme cold, or excessive radiation.


Grade 3 Hematosalpinx, CTCAE

Transfusion indicated; invasive intervention indicated


Bladder Infection, CTCAE

A disorder characterized by an infectious process involving the bladder.


Adverse Event Attributed to Disease

An indication that an adverse event is causally related to the natural history of disease.


Grade 2 Mucositis Oral, CTCAE

Moderate pain or ulcer that does not interfere with oral intake; modified diet indicated


Grade 5 Arteritis Infective, CTCAE

Death


Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Pancreatic Endocrine Glucose Intolerance, CTCAE


Sexual Aversion Disorder

A disorder characterized by recurrent or persistent extreme aversion to, and avoidance of, all genital contact with a sexual partner. The aversion to sexual contact is not attributable to another psychiatric disorder.


Gallbladder Tubular Carcinoid

A neuroendocrine tumor that arises from the gallbladder.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


Grade 2 Breast Volume and Hypoplasia, CTCAE


Grade 3 Intraoperative Gastrointestinal Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 2 Small Intestinal Mucositis, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Benign Thymoma

A thymoma that is completely surrounded by a capsule, without evidence of capsular invasion, infiltration of the surrounding tissues, and metastases.


Cutaneous Melanoma by AJCC v8 Clinical Stage

A term that refers to the clinical staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


Grade 4 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Proctitis, CTCAE

Severe symptoms; fecal urgency or stool incontinence; limiting self care ADL


Grade 3 Vaginal Perforation, CTCAE

Invasive intervention indicated


Childhood Osteoid Osteoma

An osteoid osteoma that occurs during childhood.


Grade 2 Lymph Leakage, CTCAE

Symptomatic; medical intervention indicated


Grade 4 Nephrotic Syndrome, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage IA Cervical Cancer FIGO 2009

Cervical carcinoma measuring equal or less than 5 mm in depth and equal or less than 7 mm in width. (FIGO 2009)


Primary Valvular Disorder

Heart disease that is primarily due to a valvular defect or abnormality. Valve disease that is felt to be significant but does not fulfill the definition for primary valvular heat disease is considered contributory valvular heart disease.


Grade 3 Genitourinary Stoma Obstruction, CTCAE


Merkel Cell Carcinoma by AJCC v7 Stage

A term that refers to the staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v7 classification system.


Complication of transplanted organ, NOS

A disease or disorder that is associated with a transplanted organ.


Grade 2 Hallucinations, CTCAE

Moderate hallucinations


Childhood Benign Nervous System Neoplasm

A childhood neoplasm that arises from the nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 3 Serum Hypertriglyceridemia, CTCAE


Grade 5 Nervous System Disorders - Other, Specify, CTCAE

Death


Opportunistic Infection Associated with Grade 2 or Greater Lymphopenia, CTCAE


Grade 2 Pain of Skin, CTCAE

Moderate pain; limiting instrumental ADL


Pelvic Undifferentiated High Grade Pleomorphic Sarcoma

Undifferentiated high grade pleomorphic sarcoma  involving the bones of the pelvis.


Marasmic kwashiorkor

Evidence of marasmic kwashiorkor.


Grade 2 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Chronic Orthostatic Intolerance

A condition in which there is orthostatic intolerance lasting for at least three months with associated functional impairment. (ACC/AHA)


Grade 3 Scrotal Pain, CTCAE

Severe pain; limiting self care ADL


FIGO Grade 2 Endometrioid Adenocarcinoma

Endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


Recurrent Malignant Urinary System Neoplasm

Reemergence of a malignant urinary system neoplasm after a period of remission.


Grade 4 Hyperphosphatemia, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., dialysis)


Grade 5 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Grade 1 Thyroid Stimulating Hormone Increased, CTCAE

TSH increased and no intervention initiated


Iron deficiency without anemia

Subnormal concentrations of iron resulting from low iron intake, inefficient iron absorption in the gastrointestinal tract, or increased iron loss; occurring in the absence of anemia.


Stage I Esophageal Adenocarcinoma AJCC v7

Stage I includes: IA (T1, N0, M0, G1-2, X); IB (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Acute Myocardial Injury without Ischemia, Heart Failure, Ventricular Dysfunction, or Myocarditis Related to COVID-19

Acute myocardial injury, without evidence of acute ischemia, heart failure, a newly reduced left or right ventricular ejection fraction, cardiogenic shock, or myocarditis in a patient with probable or confirmed acute COVID-19.


Grade 3 Alcohol Intolerance, CTCAE

Severe symptoms; limiting self care ADL


Grade 3 Acidosis, CTCAE

pH <7.3


Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8

Stage IIIB includes: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Advanced gastric carcinoma

Gastric carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Refractory Dedifferentiated Liposarcoma

Dedifferentiated liposarcoma that does not respond to treatment.


Unresectable Prostate Small Cell Neuroendocrine Carcinoma

Prostate small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Flushing, CTCAE 5.0

A disorder characterized by episodic reddening of the skin, especially face, neck, or chest.


Cellulitis of pharynx

Cellulitis of the pharynx.


Grade 2 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


High grade cervical glandular intraepithelial neoplasia

Cervical glandular intraepithelial neoplasia characterized by the presence of severe dysplastic changes.


Grade 3 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Severe Adverse Event

An adverse event experience that requires intensive therapeutic intervention and interrupts usual daily activities.


Extrahepatic bile duct cancer stage III

Stage III includes: T4, Any N, M0.  T4: Tumor invades any of the following main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: Distant metastasis. (AJCC 6th ed.)


Aplastic bone marrow

Depletion of stem cells in the bone marrow that results in the lack of production of hematopoietic cells.


Grade 2 Pleura Intra-Operative Injury, CTCAE


Cerebellar Paraganglioma

An extra-adrenal paraganglioma arising from the cerebellum.


Grade 4 Oral Intra-Operative Injury, CTCAE


Lymphoma by Lukes-Collins Classification (Antiquated)


High Grade Prostatic Intraepithelial Neoplasia

Prostatic intraepithelial neoplasia characterized by the presence of morphologically malignant cells lining the acini and ducts.  The malignant cells are enlarged, contain prominent nucleoli, and have increased nuclear/cytoplasmic ratio.  The malignant cells may grow within the ducts and acini in four architectural patterns: flat, tufting, micropapillary, and cribriform.  The presence of high grade prostatic intraepithelial neoplasia in needle biopsy is a risk factor for the subsequent detection of carcinoma on repeat biopsy.


Grade 5 Intraoperative Renal Injury, CTCAE

Death


Grade 5 Pyramidal Tract Syndrome, CTCAE

Death


Grade 2 Feminization Acquired, CTCAE

Moderate symptoms; medical intervention indicated


Stage IV Ureter Cancer AJCC v7

Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  N1: Distant metastasis.  (AJCC 7th ed.)


Grade 2 Urinary Incontinence, CTCAE

Spontaneous; pads indicated; limiting instrumental ADL


Grade 5 Duodenal Hemorrhage, CTCAE

Death


Grade 4 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Mixed Phenotype Acute Leukemia, B/T/Myeloid, Not Otherwise Specified

A very rare mixed phenotype acute leukemia in which the blasts show evidence of B-cell, T-cell, and myeloid lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


Grade 3 Ileal Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Bladder Urothelial Carcinoma, High Grade

Bladder urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


Grade 3 Hypoxia, CTCAE

Decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg)


Crude Oil Exposure

Environmental, occupational, or consumer-based exposure to volatiles derived from the organic compounds and polycyclic aromatic hydrocarbons and particulates that are present in crude oil.


EBV-Related Post-Transplant Lymphoproliferative Disorder

A lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection.


Stage I Lentigo Maligna Melanoma AJCC v7

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 3 Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


Lacrimal Drainage System Mucoepidermoid Carcinoma

A carcinoma that arises from the lacrimal sac. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Paratesticular tumor

A benign, borderline, or malignant neoplasm that affects the paratesticular structures.


Grade 4 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 1 Pulmonary Hypertension, CTCAE

Minimal dyspnea; findings on physical exam or other evaluation


Pathologic Stage III Merkel Cell Carcinoma AJCC v8

Stage III includes: IIIA: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0); IIIB: (T1-4, N1b-3, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Hypothalamic Gangliocytoma

A tumor characterized by the presence of mature ganglion cells and neuronal differentiation, arising in the hypothalamus. It is often associated with the presence of pituitary gland adenomas. Symptoms include acromegaly and precocious puberty.


Solicited Adverse Event

An adverse event that is reported by a healthcare professional, consumer, or patient through an organized data collection system.


Grade 5 Gastrointestinal Stoma Necrosis, CTCAE

Death


AIDS-Related Cervical Carcinoma

A carcinoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


CNS Necrosis and Cystic Progression, CTCAE


First-degree perineal laceration during delivery

Injury to perineal skin only. (reVITALize)


Emaciation

An extreme loss of muscle and subcutaneous fat that is caused by malnutrition, and which results in a severely thin (emaciated) appearance.


Grade 4 Vaginal Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


P1 Hydronephrosis

Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is 10 to less than 15 mm, 2) central calyceal dilation may be present, but peripheral calyceal dilation is considered to increase risk, 3) renal parenchyma should have normal thickness and appearance, 4) the ureter is not seen, and 5) the bladder is normal. If there is central calyceal dilation but the APRPD is less than 10 mm, it is still considered UTD P1. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Anosmia, CTCAE

A disorder characterized by a change in the sense of smell.


Grade 4 Prostate Stricture or Stenosis, CTCAE


Acute Myeloid Leukemia with t(4;11)(q21.3;q23.3); AFF1-KMT2A

An acute myeloid leukemia associated with t(4;11)(q21.3;q23.3) resulting in AFF1-KMT2A gene fusion.


Upper Aerodigestive Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Psoriatic arthritis with distal interphalangeal joint involvement

Psoriatic arthritis with a particular pattern of involvement that affects the joints closest to the nails in both fingers and toes.


Grade 1 Conjunctiva Intra-Operative Injury, CTCAE


Hereditary Transthyretin Amyloid Cardiomyopathy

Transthyretin amyloid cardiomyopathy caused by mutation(s) in the TTR gene, encoding transthyretin.


Grade 4 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Aerodigestive Invasive Malignancy

A finding indicating the presence of an invasive malignant neoplasm involving the respiratory tract and the upper digestive tract.


Grade 4 Bronchopulmonary Dysplasia, AE

An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND need for greater than 30% oxygen AND positive pressure at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; need for greater than 30% oxygen AND positive pressure by 56 days postnatal age in infants born greater than 32 weeks' gestation; need for greater than 30% oxygen AND positive pressure at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


Grade 1 Gastroesophageal Reflux Disease, CTCAE

Mild symptoms; intervention not indicated


Acute Myeloid Leukemia with BCOR-RARA

Acute myeloid leukemia with variant RARA rearrangement and expression of BCOR-RARA fusion protein.


Childhood Endocrine Neoplasm

A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ during childhood.


Stage IA Pancreatic Cancer AJCC v8

Stage IA includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Urostomy Site Bleeding, CTCAE

A disorder characterized by bleeding from the urostomy site.


Grade 2 Cranial Nerve X Neuropathy, CTCAE


Grade 1 Eye Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated; no change in vision


Hepatic Hemorrhage, CTCAE

A disorder characterized by bleeding from the liver.


Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Necrotizing Enterocolitis, AE

An adverse event in a newborn characterized by confirmed necrotizing enterocolitis; major care change indicated (e.g. NPO, antibiotics, non-urgent surgery).


Childhood Acute Lymphoblastic Leukemia CNS-Positive Toronto Guidelines v2

Clinical signs of CNS involvement or blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Substance Intoxication Delirium

A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance intoxication.


Lip Infection, CTCAE

A disorder characterized by an infectious process involving the lips.


Grade 5 Oral Hemorrhage, CTCAE

Death


Stage IIIA Uterine Corpus Cancer AJCC v7

Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Grade 3 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pericarditis, CTCAE

A disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart).


Grade 4 Hypokalemia, CTCAE

<2.5 mmol/L; life-threatening consequences


Grade 4 Lipase Increased, CTCAE

>5.0 x ULN and with signs or symptoms


Grade 3 Fallopian Tube Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Cutaneous Hematopoietic and Lymphoid Cell Neoplasm

A myeloid or lymphoid cell neoplasm involving the skin.


Grade 2 Intraoperative Reproductive Tract Injury, CTCAE

Partial resection of injured organ/structure indicated


Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during adulthood.


Acute Myeloid Leukemia with SRSF2 Mutation

An acute myeloid leukemia associated with SRSF2 gene mutation.


Stage IV Vulvar Cancer AJCC v8

Stage IV includes: T1-T3, N3, M0-M1. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


Grade 4 Papulopustular Rash, CTCAE

Life-threatening consequences


Adverse Event Associated with Growth and Development


Shingles, CTCAE

A disorder characterized by the reactivation of herpes zoster virus.


Adverse Event Associated with the Nervous System


Locally Advanced Lymphoma

Lymphoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 4 Visceral Arterial Ischemia, CTCAE

Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


High Grade Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is high grade.


Prostatic Hemorrhage, CTCAE

A disorder characterized by bleeding from the prostate gland.


Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Conditioned Insomnia

Insomnia that results from a developed tendency to not sleep well under particular conditions.


Broad Ligament Serous Cystadenoma

A rare serous cystadenoma arising from the broad ligament.


Grade 3 Aortic Valve Disease, CTCAE

Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention


Grade 3 Jejunal Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated


Childhood Dermal Nevus

A dermal nevus that occurs during childhood.


Adenocarcinoma in situ in villous adenoma

A non-invasive adenocarcinoma arising from a villous adenoma.


Childhood Gemistocytic Astrocytoma

A gemistocytic astrocytoma that occurs during childhood.


Grade 1 Trachea Intra-Operative Injury, CTCAE


Vaginal Mesonephric Adenocarcinoma

Vaginal adenocarcinoma that derives from Wolffian duct remnants and shows mesonephric differentiation.


FIGO Stage IIB Gestational Trophoblastic Tumor


Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Adult Acquired Toxoplasmosis

Toxoplasmosis acquired in adulthood.


High Grade Sarcoma

A sarcoma with the morphologic features of a high grade tumor and lack of differentiation.


Grade 4 Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Conduction Disorder, CTCAE

A disorder characterized by pathological irregularities in the cardiac conduction system.


Grade 2 Pharyngeal Mucositis, CTCAE

Moderate pain, analgesics indicated; altered oral intake; limiting instrumental ADL


Grade 4 Extrapyramidal Disorder, CTCAE

Life-threatening consequences; urgent intervention indicated


Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Uterus Stricture or Stenosis, CTCAE


Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Infusion Related Toxicity

Toxicity related to an infusion.


Locally Recurrent Malignant Neoplasm

The reemergence of a malignant neoplasm after a period of remission at the site of the original tumor or adjacent to it.


Pediatric Obesity

A condition in which a child's body mass index (BMI) falls at or above the 95th percentile based on the normative values for the age and sex of the reference population.


Grade 5 Abdominal Infection, CTCAE

Death


Cerebellar Glioblastoma

A glioblastoma that occurs in the cerebellum.


Grade 4 Sinus Disorder, CTCAE

Necrosis of soft tissue or bone; urgent operative intervention indicated


Acute Lymphoblastic Leukemia by ROSE Cluster

Unique gene expression-based patient cluster groups in high-risk B-precursor acute lymphoblastic leukemia determined by Recognition of Outliers by Sampling Ends (ROSE).


Bilateral Proliferative Retinopathy

Proliferative retinopathy occurring in both eyes.


Grade 2 Duodenum Stricture or Stenosis, CTCAE


Stage IVB Bone Cancer AJCC v7

Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 2 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Ureter Stricture or Stenosis, CTCAE


Cervix Intraepithelial Neoplasia Grade 3 AJCC v7

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Umbilical hernia without mention of obstruction or gangrene

The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the umbilicus, without mention of obstruction or necrosis of the herniated contents.


Grade 2 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Locally Advanced Cervical Adenocarcinoma

A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Non-small cell carcinoma

A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma.


Tumors Derived from Langerhans Cells

This category includes two main sub-groups, according to the degree of cytological atypia and clinical aggressiveness: Langerhans cell histiocytosis and Langerhans cell sarcoma. (WHO 2017)


Racial Melanosis

A benign conjunctival finding noted especially among darker pigmented individuals. While it is typically found perilimbally and bilaterally, it can also cover the conjunctivae extensively and may present asymmetrically. The flat, non-cystic pigmentation may increase in size with age. It is rare to have this finding evolve into conjunctival melanoma.


Grade 5 Tracheal Obstruction, CTCAE

Death


Broad Ligament Wolffian Tumor

An epithelial neoplasm of Wolffian (mesonephric) origin arising from the broad ligament. Most tumors behave in a benign fashion.


Grade 1 Tendon Reflex Decreased, CTCAE

Ankle reflex reduced


Grade 3 Central Nervous System Hemorrhage, CTCAE


Grade 4 Genitourinary Stoma Obstruction, CTCAE


Pathologic Stage IIID Cutaneous Melanoma AJCC v8

Stage IIID includes: T4b, N3a/b/c, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 3 Intraoperative Neurological Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 1 Duodenum Stricture or Stenosis, CTCAE


Recurrent Acute Promyelocytic Leukemia with PML-RARA

The reemergence of acute promyelocytic leukemia with t(15;17)(q24.1;q21.2); PML-RARA after a period of remission.


Chest Pain - Cardiac, CTCAE

A disorder characterized by substernal discomfort due to insufficient myocardial oxygenation e.g., angina pectoris.


Grade 3 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Atelectasis, CTCAE

Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Grade 2 Agitation, CTCAE

Moderate mood alteration


Stage M3 Childhood Ependymoma by Toronto Guidelines v2

Visible metastasis in spine or visible metastasis in cervicomedullary junction. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Midgut Neuroendocrine Tumor

A well differentiated, low, intermediate, or high grade neoplasm that arises from the jejunum, ileum, proximal colon, or appendix.


Grade 1 Muscular and Skeletal Hypoplasia, CTCAE


Grade 3 Retroperitoneum Hemorrhage, CTCAE


Idiopathic Dysplasia of Uncertain Significance

Prominent hematopoietic cell dysplasia with mild or absent cytopenia. It may progress to an overt myelodysplastic syndrome or other myeloid neoplasms such as acute myeloid leukemia, myeloproliferative neoplasm, or mast cell disorder.


Schizophrenia and other psychotic disorders

A category of psychiatric disorders characterized by the presence of psychotic symptoms such as delusions or hallucinations or negative symptoms such as affective flattening.


Tubal Hyperplasia

Benign proliferation of the fallopian tube epithelium.


Grade 3 Concentration Impairment, CTCAE

Severe impairment in attention or decreased level of concentration; limiting self care ADL


acute combined systolic and diastolic congestive heart failure

Acute congestive heart failure due to reduced contractility of the left ventricle and which does not fill properly due to decreased compliance.


Atrioventricular Block Complete, CTCAE

A disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles.


Abnormal Finding

A decision that an observation or result is outside the parameters considered normal.


Trichilemmal carcinoma

A rare malignant tumor arising from the outer hair sheath and infundibulum on the face. It is considered the malignant counterpart of tricholemmoma. Complete surgical excision is required.


Grade 3 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Stage IIIB Vulvar Cancer AJCC v7

Stage IIIB includes: (T1/T2, N2a/N2b, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less.  N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Carbon Monoxide Diffusing Capacity Decreased, CTCAE

Asymptomatic decrease of >8 units drop; >5 units drop along with the presence of pulmonary symptoms (e.g., >Grade 2 hypoxia or >Grade 2 dyspnea); intervention indicated


Low Grade Gastric Intraepithelial Neoplasia

A gastric intraepithelial lesion characterized by the presence of neoplastic cells with mild cytologic atypia, mild architectural changes, and low number of mitotic figures.


Laryngeal Hemorrhage, CTCAE

A disorder characterized by bleeding from the larynx.


Anaplastic Large Cell Lymphoma, Lymphomatoid Papulosis-Like Histology

An anaplastic large cell lymphoma characterized by the presence of histopathologic features reminiscent of lymphomatoid papulosis. These features include the presence of Hodgkin-like cells in a background of acute and chronic inflammation.


Grade 3 Ascites, CTCAE

Severe symptoms; invasive intervention indicated


Sinus Tachycardia, CTCAE 5.0

A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node.


Hodgkin's disease, lymphocytic depletion of lymph nodes of multiple sites

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Adenocarcinoma of the prostate stage III

Stage III includes: T3a-b, N0, M0, Any PSA, Any Gleason.  cT3a: Tumor with extracapsular extension (unilateral or bilateral).  pT3a: Tumor with extraprostatic extension or microscopic invasion of bladder neck.  T3b: Tumor invades seminal vesicle(s).  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Neonatal Intraventricular Hemorrhage, AE

An adverse event in a newborn characterized by bleeding into the lateral cerebral ventricles.


Grade 3 Peritoneal Cavity Intra-Operative Injury, CTCAE


Grade 1 Pleuritic Pain, CTCAE

Mild pain


Erosion lesion

An eating away or breakdown of any type of external or internal human tissue including but not limited to skin, teeth, mucosa, or somatic, which involves only the outer tissue layer. When tissue surrounds an implanted device, the tissue breakdown may result in migration and loss of the implant material and may result in further complications such as infection or abscess.


Grade 1 Myelitis, CTCAE

Asymptomatic; mild signs (e.g., Babinski's reflex or Lhermitte's sign)


Unresectable Ampulla of Vater Carcinoma

Carcinoma that arises from the ampulla of Vater and is not amenable to surgical resection.


Grade 3 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Biliary Tract Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 5 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Carcinoma Metastatic to the Skin

A carcinoma that has spread to the skin from its original site of gowth.


Testicular Non-Neoplastic Disorder

A non-neoplastic disorder that affects the testis.  Representative examples include infection, torsion, and infarction.


Grade 3 Injury To Inferior Vena Cava, CTCAE

Severe symptoms; limiting self care ADL; repair or revision indicated


Endocrine Disorders - Other, Specify, CTCAE


Mucosal Infection, CTCAE

A disorder characterized by an infectious process involving a mucosal surface.


Grade 3 Hematoma, CTCAE

Transfusion; invasive intervention indicated


Advanced Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Metastatic Melanoma

Metastatic melanoma that is resistant to treatment.


Stage IV Bone Sarcoma AJCC v7

Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 5 Fallopian Tube Obstruction, CTCAE


Pancreatic Hepatoid Adenocarcinoma

A rare adenocarcinoma that arises from the pancreas.  It is characterized by marked hepatocellular differentiation.


Stage I Ampulla of Vater Cancer AJCC v8

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2, N0, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Other Dermatology or Skin, CTCAE


Mammary duct ectasia

Dilatation of the lumen of the mammary ducts without evidence of epithelial atypia.


Acute Myeloid Leukemia with idic(X)(q13)

Acute myeloid leukemia associated with isodicentric chromosome Xq13 [idic(X)(q13)].


Grade 3 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Kidney Pain, CTCAE

Kidney pain that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


Grade 4 Urethral Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Non-Muscle Invasive Bladder Urothelial Carcinoma

An infiltrating urothelial carcinoma of the bladder that has not invaded into the bladder muscularis propria.


Cranial Nerve VIII Intra-Operative Injury, CTCAE


Grade 1 Prolapse of Intestinal Stoma, CTCAE

Asymptomatic; reducible


Grade 5 Surgical and Medical Procedures - Other, Specify, CTCAE

Death


Grade 1 Gallbladder Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Non-Invasive Cribriform Carcinoma

A carcinoma characterized by the presence of a cribriform architectural pattern. There is no evidence of surrounding stromal invasion by the malignant cells.


Chronic Myelomonocytic Leukemia with Eosinophilia Associated with t(5;12)(q31;p12)

Chronic myelomonocytic leukemia characterized by the presence of eosinophilia, PDGFRB gene rearrangement, and t(5;12)(q31;p12).


Torsade de Pointes, CTCAE

A type of polymorphic ventricular tachycardia (VT) characterized by a gradual change in the amplitude and twisting of the QRS complexes around the isoelectric line.


Grade 1 Platelet Count Decreased, CTCAE

<LLN-75,000/mm3; <LLN-75.0 x 10e9/L


Stage IVB Oral Cavity Verrucous Carcinoma


Stage IVA Gallbladder Cancer AJCC v8

Stage IVA includes: T4, N0-1, M0. T4: Tumor invading the main portal vein or hepatic artery or invading two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 3 Aspartate Aminotransferase Increased, CTCAE

>5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


Grade 4 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Urinary Tract Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Mitochondrial Uncoupling Protein 2 Hyperinsulinism

Hyperinsulinism due to mutation(s) in the gene UCP2, encoding mitochondrial uncoupling protein 2, which plays a role in attenuating insulin secretion.


Supratentorial Ependymoma

A circumscribed ependymoma that arises from the supratentorial region of the brain. The diagnosis of supratentorial ependymoma should be made either when genetic analysis did not reveal a fusion gene involving ZFTA or YAP1 genes (not elsewhere classified -NEC) or when the genetic analysis was unsuccessful or not reported (not otherwise specified-NOS).


Pediatric Disorder

A non-neoplastic or neoplastic disorder which occurs during infancy, childhood, or adolescence.


Grade 4 Atrioventricular Block Complete, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Renal Colic, CTCAE

Hospitalization indicated; limiting self care ADL


Non-Neoplastic Anorectal Disorder

A non-neoplastic disorder that affects the anus and rectum.


Grade 5 Pleural Effusion, CTCAE

Death


Grade 4 Spinal Fracture, CTCAE

Life-threatening consequences; symptoms associated with neurovascular compromise


Grade 1 Major Visceral Artery Intra-Operative Injury, CTCAE


Grade 4 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Uterine Fistula, CTCAE

A disorder characterized by an abnormal communication between the uterus and another organ or anatomic site.


Grade 1 Breast Volume and Hypoplasia, CTCAE


Grade 3 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Libido Increased, CTCAE

A disorder characterized by an increase in sexual desire.


Columnar Cell Change of the Breast with Atypia

A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by one or two layers of columnar epithelial cells.  Cytologic atypia is present.


Grade 3 Cranial Nerve IV Intra-Operative Injury, CTCAE


Grade 1 Teeth Intra-Operative Injury, CTCAE


Grade 5 Hypophysitis, CTCAE

Death


Grade 2 Glaucoma, CTCAE

EIOP which can be reduced to 21 mmHg or under with topical medications and no visual field deficit


Grade 2 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Ear and Labyrinth Disorders - Other, Specify, CTCAE


Body Odor, CTCAE

A disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body.


Asymptomatic Inflammatory Prostatitis

Inflammation of the prostate gland that is not associated with any symptoms. It is characterized by the presence of inflammatory cells in the prostatic fluid.


Extramural Nodule

A small aggregate of cells found in adipose tissues, particularly those attached to the colon where the architectural details of the lymph node cannot be identified with certainty under the microscope.  It may represent a lymph node completely replaced by metastatic cancer.


Complete unbalanced atrioventricular canal defect

Atrioventricular septal defect in which there is usually a single dominant ventricle and a hypoplastic ventricle.