Refractory Endometrial Clear Cell Adenocarcinoma

Endometrial clear cell adenocarcinoma that is resistant to treatment.


Grade 3 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE

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Locally Advanced Extrapulmonary Neuroendocrine Carcinoma

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Extrapulmonary neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Growth Hormone Abnormal, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Reflux

An abnormal backward flow of a body fluid.


Ileal Hemorrhage, CTCAE

A disorder characterized by bleeding from the ileal wall.


Infant T Acute Lymphoblastic Leukemia

A T-acute lymphoblastic leukemia that occurs in infancy.


Grade 2 Cecal Infection, CTCAE

Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Metastatic Urethral Carcinoma

Urethral carcinoma that has spread to another anatomical site.


Mediastinum Intra-Operative Injury, CTCAE


FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


Mucositis Oral, CTCAE

A disorder characterized by ulceration or inflammation of the oral mucosal.


Cataract, CTCAE 5.0

A disorder characterized by partial or complete opacity of the crystalline lens of one or both eyes. This results in a decrease in visual acuity and eventual blindness if untreated.


Beta-2-Microglobulin Greater than 3 g/mL

A laboratory test result indicating that beta-2-microglobulin is present in a sample at concentrations exceeding 3 g/mL.


Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia

Acute myeloid leukemias arising as a result of the mutagenic effect of therapeutic agents targeting DNA-topoisomerase II. The vast majority of patients present without a preceding myelodysplastic phase. The acute myeloid leukemias are usually of the monoblastic or myelomonocytic type. Clonal cytogenetic abnormalities are frequently present and usually involve chromosome 11q23 (MLL gene).


Grade 5 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Neonatal Fever, AE

An adverse event in a newborn characterized by elevation of body temperature above normal due to the production of more heat than the body is able to dissipate.


Insomnia, CTCAE 5.0

A disorder characterized by difficulty in falling asleep and/or remaining asleep.


Grade 5 Neonatal Bradyarrhythmia, AE

A bradyarrhythmia adverse event in a newborn which results in death.


Grade 4 Cranial Nerve IV Intra-Operative Injury, CTCAE


Refractory Mucosal Melanoma

Mucosal melanoma that is resistant to treatment.


Glucokinase-Associated Hyperinsulinism

Hyperinsulinism due to activating mutation(s) in the gene GCK, encoding glucokinase.


Grade 4 Neonatal Pneumothorax, AE

A pneumothorax adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise (e.g. tension pneumothorax); urgent major care change required.


Childhood Grade I Meningioma

A grade I meningioma that occurs during childhood.


Grade 4 Rectal Ulcer, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 1 Accessory Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Pelvic Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the pelvis.


Adverse Event Associated with Sexual and Reproductive Function


Grade 1 Blood Gonadotrophin Abnormal, CTCAE


Serum Glutamic Oxaloacetic Transaminase, CTCAE


Grade 4 Cervicitis Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Associated with the Teeth, CTCAE


Grade 3 Duodenal Perforation, CTCAE

Invasive intervention indicated


Grade 3 Serum Amylase Increased, CTCAE

>2.0-5.0 x ULN with signs or symptoms; >5.0 x ULN and asymptomatic


Serum Bicarbonate Decreased

A laboratory test result which indicates decreased levels of bicarbonate in the serum.


Stage 0 Childhood Retinoblastoma by Toronto Guidelines v2

The tumor is confined to the globe. Enucleation has not been performed. (The patient is treated "conservatively" with either focal therapies or chemotherapy.) (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 2 Bloating, CTCAE

Symptomatic, decreased oral intake; change in bowel function


Grade 3 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Larynx Intra-Operative Injury, CTCAE


Childhood Astroblastoma, MN1-Altered

An astroblastoma, MN1-altered that occurs during childhood.


Stage IIIA Prostate Cancer AJCC v8

Stage IIIA includes: T1-2, N0, M0, PSA 20 or more, Grade Group 1-4; T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


Invasive Bladder Conventional Urothelial Carcinoma

Invasive bladder urothelial carcinoma characterized by the presence of malignant cells forming trabeculae, cords, sheets, and nests. Individual malignant cells are also present.


Grade 2 Nystagmus, CTCAE

Moderate symptoms; limiting instrumental ADL


FNCLCC Sarcoma Grade 1

A sarcoma with a total score of 2 or 3 according to the FNCLCC guidelines.


Refluxing Megaureter

A megaureter that demonstrates retrograde urine flow without ureteral obstruction.


Grade 5 Photosensitivity, CTCAE

Death


Grade 3 Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Prolapse of Intestinal Stoma, CTCAE

Recurrent after manual reduction; local irritation or stool leakage; difficulty to fit appliance; limiting instrumental ADL


Grade 2 Periorbital Infection, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Grade 4 Small Bowel Obstruction NOS, CTCAE


Grade 3 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malignant urinary tract neoplasm metastatic

The spread of a malignant neoplasm to the urinary tract from an adjacent or distant anatomic site.


Prolonged QTc Interval, CTCAE

An adverse event characterized by an abnormally long interval between the start of the Q wave and the end of the T wave in the heart's electrical cycle, corrected for heart rate.


Grade 3 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


Grade 1 Neonatal Pneumothorax, AE

An adverse event in a newborn characterized by radiological evidence of pneumothorax; no clinical signs; no care change required.


Grade 5 Joint Infection, CTCAE

Death


transvestism

A disorder characterized by recurrent sexual urges, fantasies, or behaviors in a heterosexual male involving cross-dressing.


Grade 4 Death Neonatal, CTCAE

Neonatal loss of life


adenocarcinoma of gallbladder with squamous metaplasia

An infiltrating adenocarcinoma of the gallbladder characterized by the presence of metaplastic changes of the malignant glandular cells to squamous cells.


Grade 3 Adult Respiratory Distress Syndrome, CTCAE

Present with radiologic findings; intubation not indicated


Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for Hodgkin lymphomas based on the Ann Arbor classification criteria.


Complicated malaria

Acute malaria with signs of organ dysfunction, severe anemia (hemoglobin less than 5 g/dL or hematocrit less than 15%) and/or hyperparasitemia (greater than 5% of red blood cells infected).


Papillary transitional cell carcinoma, non-invasive

A transitional cell carcinoma characterized by a papillary growth pattern and lack of stromal invasion.


Grade 3 Encephalomyelitis Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


High Grade Prostatic Intraepithelial Neoplasia, Inverted Variant

High grade prostatic intraepithelial neoplasia characterized by the presence of secretory cells with their nuclei polarized towards the lumen of the glands.


Grade 3 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gallbladder Intra-Operative Injury, CTCAE


Non-Neoplastic Conjunctival Disorder

A non-neoplastic disorder that affects the conjunctiva.


Unresectable Bladder Carcinoma

Bladder carcinoma that is not amenable to surgical resection.


Grade 3 Psychiatric Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; limiting self care ADL


Stage I Adult Diffuse Small Cleaved Cell Lymphoma

Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Stage IV Prostate Cancer AJCC v7

Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


Ileal Fistula, CTCAE

A disorder characterized by an abnormal communication between the ileum and another organ or anatomic site.


Sinus Disorder, CTCAE

A disorder characterized by involvement of the paranasal sinuses.


Diffuse Low Grade Glioma, BRAF p.V600E-Mutant

Diffuse low-grade glioma characterized by the presence of BRAF gene mutations encoding a p.V600E substitution mutation.


Grade 5 Colon or Cecum or Appendix Fistula, CTCAE


Pathologic Stage IIIB Cutaneous Melanoma AJCC v8

Stage IIIB includes: (T0, N1b, N1c, M0); (T1a/b-T2a, N1b/c or N2b, M0); (T2b/T3a, N1a-N2b, M0). T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration.  T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 3 Lung Thoracic Nerve Intra-Operative Injury, CTCAE


Recurrent Brain Neoplasm

The reemergence of a brain neoplasm after a period of remission.


A myelodysplastic/myeloproliferative neoplasm that is resistant to treatment.


Grade 2 Productive Cough, CTCAE

Moderate sputum production; limiting instrumental ADL


Postoperative Spindle Cell Nodule of the Vagina

A rare, benign, non-neoplastic reactive lesion that develops in the vagina at the site of a prior operative procedure. It is composed of spindle cells, small blood vessels, and chronic inflammation.


Chemical Exposure

Contact with a chemical substance through touch, inhalation, or ingestion.


Radiation-Induced Cancer

A malignant neoplasm arising in a site exposed to radiation therapy.


Carbon Monoxide Diffusion Capacity, CTCAE


Grade 1 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Vulvar Blue Nevus

A benign nevus that arises from the vulva and is characterized by the presence of heavily pigmented dendritic melanocytes exclusively in the dermis.


Grade 2 Pelvis Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Weight Change

An increase or decrease in the weight of an individual.


Non-Malignant Neoplasm

A category that includes benign neoplasms and neoplasms with uncertain malignant potential. The latter are characterized by clinicopathological features that are not benign, including some degree of mild or mild/moderate atypia/dysplasia, but lack overt malignant morphologic characteristics and there is no evidence of metastasis at the time of diagnosis.


Edema Face, CTCAE

A disorder characterized by swelling due to excessive fluid accumulation in facial tissues.


Grade 2 Rash Acneiform, CTCAE

Papules and/or pustules covering 10-30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL; papules and/or pustules covering > 30% BSA with or without mild symptoms


Gonadal Thrombosis

Formation of a blood clot (thrombus) in the lumen of the vein that carries blood away from the testis or ovary.


Grade 2 Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Endocrine Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 4 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Gastric carcinoma stage IV without metastases

T4,N2,MO (from PDQ)


Grade 4 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Anorexia, CTCAE

A disorder characterized by a loss of appetite.


Therapy-Related Toxicity

The finding of bodily harm due to the poisonous effects associated with the action or administration of therapeutic agents.


Grade 5 External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Soft Tissue Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Myelitis, CTCAE

A disorder characterized by inflammation involving the spinal cord. Symptoms include weakness, paresthesia, sensory loss, marked discomfort and incontinence.


Stage IIIB Testicular Cancer AJCC v8

Stage IIIB includes: (Any pT/TX, N1-3, M0, S2); (Any pT/TX, Any N, M1a, S2). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. S2: LDH 1.5-10 x N or hCG (mlU/mL) 5,000-50,000 or AFP (ng/mL) 1,000-10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Endocarditis Infective, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Goblet Cell Adenocarcinoma

A rare adenocarcinoma that exhibits neuroendocrine differentiation and is associated with the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.


Grade 2 Esophageal Obstruction, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Transplant-Related Carcinoma

A carcinoma that arises in a patient with a history of organ transplantation.


Stage IA2 Cervical Cancer AJCC v9

Stage IA2 includes: T1a2, N0, M0. T1a2: Tumor with measured stromal invasion of more than 3.0 mm and equal or less than 5.0 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Duodenal fistula

An abnormal communication between the duodenum and another organ or cavity.


Stage I Gallbladder Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or muscular layer. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Neonatal Edema, AE

An adverse event in a newborn characterized by mild edema; no change in age appropriate behavior; no care changes indicated.


Grade 1 Intraoperative Reproductive Tract Injury, CTCAE

Primary repair of injured organ/structure indicated


Peritoneal gliomatosis

A benign condition characterized by the presence of peritoneal implants composed of mature glial tissue. It is usually accompanied by an ovarian teratoma.


Grade 5 Neuroendocrine ACTH Deficiency, CTCAE


Grade 3 Wound Dehiscence, CTCAE

Fascial disruption or dehiscence without evisceration; revision by operative intervention indicated


Grade 2 Neutrophils and Granulocytes, CTCAE


Grade 4 Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Defined Adverse Event

An adverse event that has a concise explanation of the meaning of term.


Recurrent Hematologic Malignancy

The reemergence of a hematologic malignancy after a period of remission.


Stage II Adult Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 4 Mucositis Oral, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

Death


Seizure, CTCAE 5.0

A disorder characterized by a sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin.


Hemoglobin Lepore Syndrome

A beta thalassemia resulting from an unequal crossover/recombination event involving portions of the delta and beta globin genes, resulting in underproduction of the abnormal delta-beta globin.


Unresectable Pancreatic Neuroendocrine Tumor

Pancreatic neuroendocrine tumor that is not amenable to surgical resection.


round cell sarcoma with FUS-NFATC2 gene fusion

A group of rare round and spindle cell sarcomas characterized by the presence of FUS-NFATC2 gene fusion.


Grade 3 Ileal Obstruction, CTCAE

Hospitalization indicated; invasive intervention indicated; limiting self care ADL; long intestinal tube indicated


Lupus Flare

An exacerbation of the chronic disease lupus.


Grade 3 Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Palisaded encapsulated neuroma

A benign peripheral nerve sheath tumor characterized by the presence of Schwann cells, axons, and perineurial fibroblasts.  It usually arises from the skin of the head and neck or the oral mucosa.  It presents as a solitary and painless nodular mass.


Papilledema, CTCAE

A disorder characterized by swelling around the optic disc.


Refractory Meningioma

Meningioma that is resistant to treatment.


Mental and Behavioral Signs and Symptoms

Clinical evidence of disease resulting from mental and/or behavioral dysfunction.


Small Bowel NOS Intra-Operative Injury, CTCAE


Grade 3 Eye Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Advanced Carcinoma

Carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Heart Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Vein Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage II Cervical Cancer AJCC v9

Stage II includes: T2, N0, M0. T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Cholecystitis, CTCAE 5.0

A disorder characterized by inflammation involving the gallbladder. It may be associated with the presence of gallstones.


Grade 4 Upper Gastrointestinal Hemorrhage, CTCAE


Grade 3 Cranial Nerve I Neuropathy, CTCAE


Pathologic Stage IIIC Cutaneous Melanoma AJCC v8

Stage IIIC includes: (T0, N2b, N2c, N3b or N3c); (T1a-T3a, N2c or N3a/b/c, M0); (T3b/T4a, Any N greater than or equal to N1, M0); (T4b, N1a-N2c, M0). T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N2c: One clinically occult nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 3 Inner Ear Intra-Operative Injury, CTCAE


Grade 4 Neonatal Epileptic Seizure, AE

An adverse event in a newborn characterized by electroencephalogram (EEG)- proven seizures with life-threatening consequences (e.g. need for ventilation); status epilepticus (greater than 30 minutes of seizure activity within any 60 minute period) despite multiple anti-seizure drugs.


Concentration Impairment, CTCAE

A disorder characterized by a deterioration in the ability to concentrate.


Localized Non-Muscle Invasive Bladder Urothelial Carcinoma

A bladder urothelial carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites, and has not invaded the bladder muscularis propria.


Grade 3 Colon or Cecum or Appendix Fistula, CTCAE


Epilepsy aggravated

An increase in the duration or intensity of epileptic symptoms in the setting of chronic epilepsy.


Epithelioid Hemangioendothelioma with YAP1-TFE3 Gene Fusion

Epithelioid hemangioendothelioma characterized by a YAP1-TFE3 gene fusion. This gene fusion occurs in a subset of epithelioid hemangioendotheliomas characterized by the presence of well-formed vessels lined by epithelioid endothelial cells with abundant eosinophilic cytoplasm. Patients with YAP1-TFE3 gene fusion tumors tend to be younger than those with a WWTR1-CAMTA1 gene fusion.


Neoantigen-Positive Malignant Solid Neoplasm

A malignant solid neoplasm characterized by the expression of antigens resulting from cancer-specific mutations (neoantigens).


Capillary Leak Syndrome, CTCAE

A disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure.


Grade 3 Visceral Arterial Ischemia, CTCAE

Prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated


Peripheral Sensory Neuropathy, CTCAE

A disorder characterized by damage or dysfunction of the peripheral sensory nerves.


Grade 2 Personality Change, CTCAE

Moderate personality change


Lugano Classification Stage IIE Adult Hodgkin Lymphoma AJCC v8

Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Femoral Hernia with Obstruction without Mention of Gangrene

The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis, with no mention of necrosis of the herniated contents.


Grade 2 Esophagus Stricture or Stenosis, CTCAE


Postoperative Thoracic Procedure Complication, CTCAE

A finding of a previously undocumented problem that occurs after a thoracic procedure.


Grade 2 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Pancreatic Enzymes Decreased, CTCAE

Increase in stool frequency, bulk, or odor; steatorrhea


Vaginal Inflammation, CTCAE

A disorder characterized by inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge.


Refractory Ependymoma

Ependymoma that does not respond to treatment.


Bodily Pain

The sensation of acute or chronic suffering in a body region.


Stage II Osteosarcoma AJCC v7

Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Metastatic Malignant Neoplasm in the Genitourinary System

The spread of a malignant neoplasm to the genitourinary system from an adjacent or distant anatomic site.


Grade 3 Testicular Disorder, CTCAE

Severe symptoms; interfering with sexual function; limiting self care ADL; intervention indicated


CRP Level Greater than or Equal to 3 mg/L

A laboratory test result indicating that C-reactive protein is present in a sample at concentrations of 3 mg/L or more.


Papulopustular Rash, CTCAE

A disorder characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back. Unlike acne, this rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions.


Grade 1 Non-Cardiac Chest Pain, CTCAE

Mild pain


Grade 2 Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


Lip Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort of the lip.


Disruptive mood dysregulation disorder

A condition in which children or adolescents experience irritability, anger, and intense temper outbursts. The episodes may be frequent and may eventually impact functioning at school, at home or with peers.


Mild Cardiac Valve Regurgitation

Evidence of mild retrograde blood flow through the valve(s) of the heart. (ACC)


Domestic Accident

An accident taking place within a home.


Grade 4 Joint Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Neuroendocrine ADH Secretion Abnormality, CTCAE


Grade 3 Intraoperative Renal Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 2 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IV Vulvar Cancer AJCC v7

Stage IV includes: IVA: (T1/T2, N3, M0); (T3, Any N, M0); IVB: (Any T, Any N, M1).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.  N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 7th ed.)


Grade 5 Voice Changes and Dysarthria, CTCAE


Stage IV Anal Canal Cancer AJCC v6 and v7

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


Grade 2 Prostatic Pain, CTCAE

Moderate pain; limiting instrumental ADL


Central Nervous System Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the brain and/or spinal cord.


Grade 5 Prolapse of Intestinal Stoma, CTCAE

Death


Transient Ischemic Attacks, CTCAE

A disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit.


Radiating Chest Pain Along Left Upper Sternal Border

The location of the radiating chest pain is along the left upper sternal border.


Acute Myeloid Leukemia with t(3;8)(q26.2;q24); MYC, MECOM

An acute myeloid leukemia associated with t(3;8)(q26.2;q24) resulting in MYC and MECOM rearrangement.


Grade 1 Laryngeal Hemorrhage, CTCAE

Mild cough or trace hemoptysis; laryngoscopic findings


Myeloid Neoplasms with Germline Predisposition without a Preexisting Disorder or Organ Dysfunction

Familial hematologic neoplasms associated with germline mutations without a preexisting disorder or organ dysfunction.


Grade 2 Soft Tissue NOS Intra-Operative Injury, CTCAE


Grade 4 Gastric Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Soft Tissue Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Chronic pulmonary aspergillosis

A spectrum of disorders associated with long-term Aspergillus infection of the lung that usually occur in immunocompetent individuals with underlying respiratory disorders, and may be characterized by pulmonary fibrosis or cavitation.


Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma

Extrapulmonary small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Middle Ear Inflammation, CTCAE

A disorder characterized by inflammation (physiologic response to irritation), swelling and redness to the middle ear.


Unresectable Digestive System Adenocarcinoma

An adenocarcinoma that arises from the gastrointestinal system and is not amenable to surgical resection.


Acquired kyphosis

Kyphosis, the cause of which is not present at birth.


Hepatic Necrosis, CTCAE 5.0

A disorder characterized by a necrotic process occurring in the hepatic parenchyma.


Cardiovascular Radiation Injury

Radiation injury of the cardiovascular system.


Grade 3 Pulmonary Valve Disease, CTCAE

Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention


COVID-19-Associated Nervous System Disorder

A central or peripheral nervous system disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Coronary Artery Ectasia Related to COVID-19

Coronary artery ectasia in a patient with probable or confirmed acute COVID-19.


Grade 2 Urinary Conduit Intra-Operative Injury, CTCAE


Grade 3 Non-Cardiac Chest Pain, CTCAE

Severe pain; limiting self care ADL


Childhood Pleomorphic Xanthoastrocytoma

A pleomorphic xanthoastrocytoma that occurs during childhood.


Glucosuria, CTCAE

A disorder characterized by laboratory test results that indicate glucose in the urine.


Grade 2 Enterocolitis, CTCAE

Abdominal pain; mucus or blood in stool


Soft Tissue Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Grade 3 Vital Capacity Abnormal, CTCAE

<50% of predicted value; limiting self care ADL


Grade 5 Recurrent Laryngeal Nerve Palsy, CTCAE

Death


Bleeding on Probing

Bleeding that is induced by gentle manipulation of the gingival tissue at the depth of the gingival sulcus.


Stage III Esophageal Cancer AJCC v7

Stage III includes: For squamous cell carcinoma: IIIA (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any); IIIB (T3, N2, M0, Any G, Tumor location: Any); IIIC (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIIA (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G); IIIB (T3, N2, M0, Any G); IIIC (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Epididymal Papillary Cystadenoma

A cystadenoma that arises from the epididymis. It is characterized by the presence of small papillary projections in the inner surface of the cysts. It may be sporadic or associated with von Hippel-Lindau disease.


Advanced Basal Cell Carcinoma

Basal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIB Bone Sarcoma AJCC v7

Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 3 Ophthalmoplegia and Diplopia, CTCAE


Grade 1 Cranial Nerve III Intra-Operative Injury, CTCAE


Grade 3 Persistent Pulmonary Hypertension of the Newborn, AE

An adverse event in a newborn characterized by Increased estimated right ventricular pressures; with severe clinical symptoms; oxygenation index greater than 25; major care changes required (e.g. inhaled nitric oxide (iNO)).


Grade 4 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Urethral Anastomotic Leak, CTCAE

Death


Grade 2 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Peritoneal Cavity Hemorrhage, CTCAE


Pathologic Stage IIA Cutaneous Melanoma AJCC v8

Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 5 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Acquired Phrenic Nerve Palsy

Damage to the phrenic nerve that results in paralysis of the hemidiaphragm and was not present at birth.


Grade 3 Genitourinary Stoma Hemorrhage, CTCAE


Grade 5 Intraoperative Endocrine Injury, CTCAE

Death


Circumscribed Meningeal Melanocytic Neoplasm

A circumscribed neoplasm that arises from leptomeningeal melanocytes. This category includes meningeal melanocytoma, meningeal melanoma, and meningeal melanocytoma of intermediate grade.


Mycosis fungoides (Working Formulation)

A peripheral (mature) T-cell lymphoma presenting in the skin with patches/plaques and it is characterized by epidermal and dermal infiltration of small to medium-sized T-cells with cerebriform nuclei.  Patients with limited disease generally have an excellent prognosis.  In the more advanced stages, the prognosis is poor. (WHO, 2001)


First degree uterine prolapse

The uterus has descended above the hymen.


Stage III Uterine Corpus Cancer AJCC v6

Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Local and/or regional spread as defined below.  T3a: Tumor invades serosa and/or adnexa (direct extension or metastasis) and/or cancer cells in ascites or peritoneal washings.  T3b Vaginal involvement (direct extension or metastasis). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic and/or para-aortic nodes.  M0: No distant metastasis. (AJCC 6th ed.)


Stage M1 Childhood Ependymoma by Toronto Guidelines v2

Tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Human Papillomavirus-Independent Vaginal Squamous Cell Carcinoma

Vaginal squamous cell carcinoma not associated with human papillomavirus infection.


Stage IIA Cervical Cancer AJCC v9

Stage IIA includes: T2a, N0, M0. T2a: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Post-streptococcal reactive arthritis

The occurrence of arthritis after infection with group A streptococcus. It is non-migratory, protracted in course, and poorly responsive to anti-inflammatory agents. (from Textbook of Pediatric Rheumatology, 6th ed. Cassidy, Petty, Laxer, and Lindsley)


Refractory Female Reproductive System Carcinoma

Female reproductive system carcinoma that is resistant to treatment.


Exercise Tolerance Test Result

The result of an evaluation of an individual's ability to endure the workload that is achieved during a specified period of exercise.


Low Grade Corneal Squamous Intraepithelial Neoplasia

A precancerous neoplastic intraepithelial process with low-grade dysplastic features involving the corneal epithelium.


Intraductal papillary neoplasm with high grade intraepithelial neoplasia

An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of severe epithelial atypia.


Grade 4 Tendon Intra-Operative Injury, CTCAE


Nuclear Cataract Grade 3

A stage of nuclear sclerotic cataract marked by pronounced yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Grade 2 Gastrointestinal Stoma Intra-Operative Injury, CTCAE


Grade 2 Irritability in Children Less Than 3 Years of Age, CTCAE


Grade 5 Upper Extremity Soft Tissue Necrosis Adverse Event, CTCAE


Platinum-Sensitive Fallopian Tube Carcinoma

Fallopian tube carcinoma that has a documented response to platinum-based chemotherapy.


Grade 4 Hearing Impaired, CTCAE

Adults: Decrease in hearing to profound bilateral loss (absolute threshold >80 dB HL at 2 kHz and above); nonservicable hearingPediatric: Audiologic indication for cochlear implant; > 40 dB HL (i.e., 45 dB HL or more); SNHL at 2 kHz and above


Gastric mucositis

An inflammatory process affecting the mucous membrane of the stomach.


Hypoxia, CTCAE

A disorder characterized by a decrease in the level of oxygen in the body.


Grade 1 Cranial Nerve IX Neuropathy, CTCAE


Stage IVA Cervical Cancer AJCC v6 and v7

Stage IVA includes: T4, Any N, M0). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (AJCC 6th and 7th eds.)


Benign neoplasm of lacrimal apparatus

A neoplasm that arises from the lacrimal gland or lacrimal drainage system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


FIGO Stage IIC Gestational Trophoblastic Tumor


Grade 2 Ventricular Tachycardia, CTCAE

Non-urgent medical intervention indicated


Grade 1 Hearing Impaired, CTCAE

Adults enrolled on a Monitoring Program (on a 1, 2, 4, 3, 6, and 8 kHz audiogram): Threshold shift of 15-25 dB averaged at 2 contiguous test frequencies in at least one ear; Adults not enrolled on a Monitoring Program: Subjective change in hearing in the absence of documented hearing loss; Pediatric (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift >20 dB hearing loss (HL) (i.e., 25 dB HL or greater); sensorineural hearing loss (SNHL) above 4 kHz (i.e., 6 or 8 kHz) in at least one ear


Lumbar myelocele

Herniation of spinal cord tissue and meninges through a defect in the lumbar region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma

Bladder clear cell (glycogen-rich) urothelial carcinoma that has spread to another anatomic site.


Grade 4 Intracranial Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Tumor Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis.


Grade 2 Non-Malignant Pleural Effusion, CTCAE


Grade 2 Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Myelodysplastic Syndrome, Unclassifiable, Based on Defining Cytogenetic Abnormality

Myelodysplastic syndrome, unclassifiable characterized by persistent cytopenia (s) with 1 percent or fewer blasts in the blood and fewer than 5% in the bone marrow, unequivocal dysplasia in less than 10 percent of the cells in one or more myeloid lineages, and cytogenetic abnormalities considered as presumptive evidence of myelodysplastic syndrome.


Achromic nevus

A benign nevus characterized by the absence of melanin pigment in the melanocytes.


Papillary neoplasm

A benign, intermediate, or malignant neoplasm characterized by the formation of papillary structures.


Grade 4 Uterus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Childhood Langerhans Cell Histiocytosis without Risk Organ Involvement

Langerhans cell histiocytosis that occurs during childhood and does not involve the bone marrow, spleen, liver, or lung.


Grade 2 Hyperphosphatemia, CTCAE

Noninvasive intervention indicated


Esophageal adenocarcinoma stage IV

An adenocarcinoma that arises from the esophagus and has metastasized to another anatomic site.


Advanced Carcinoid Tumor

A carcinoid tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Destructive Arthritis

Arthritis associated with the destruction of the cartilage and the articular surface of the bone of the joint. This process severely interferes with movement in the joint.


Grade 2 Laryngospasm, CTCAE

Transient episode; intervention not indicated


Lymphoma by Ann Arbor Stage

An anatomic stage for Hodgkin and non-Hodgkin lymphomas  based on the Ann Arbor classification criteria.


Lower Extremity Vein Intra-Operative Injury, CTCAE


Bilateral glaucoma

Increased pressure in both eyeballs due to obstruction of the outflow of aqueous humor.


Chest Pain Along Left Midclavicular Line

The location of the chest pain is along the left midclavicular line.


Recurrent Childhood Malignant Neoplasm

The reemergence of a childhood malignant neoplasm after a period of remission.


Grade 4 Aspartate Aminotransferase Increased, CTCAE

>20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal


Grade 1 Recurrent Laryngeal Nerve Palsy, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Locally Advanced Malignant Female Reproductive System Neoplasm

A malignant female reproductive system neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Intraoperative Reproductive Tract Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Intercalated Duct Hyperplasia

A salivary ductal proliferation resembling intercalated ducts. (WHO 2017)


Childhood Diabetes Mellitus

Diabetes mellitus that develops during childhood.


Grade 3 Vein NOS Intra-Operative Injury, CTCAE


Grade 2 Pancreatic Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Precursor T-lymphoblastic lymphoma/leukemia recurrent

The reemergence of T-lymphoblastic leukemia/lymphoma after a period of remission.


Vaginal Undifferentiated Carcinoma

A carcinoma that arises from the vagina and is characterized by the lack of specific cellular differentiation.


Neuroendocrine Gonadotropin Secretion Abnormality, CTCAE


autosomal recessive dyskeratosis congenita 5

Dyskeratosis congenita caused by mutation(s) in the RTEL1 gene, encoding regulator of telomere elongation helicase 1.


Musculoskeletal Chest Pain due to Costochondritis

A condition in which there is musculoskeletal chest pain associated with inflammation of one or more ribs and/or cartilages. (ACC/AHA)


Grade 2 Platelet Count Decreased, CTCAE

<75,000-50,000/mm3; <75.0-50.0 x 10e9/L


Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8

Stage IV includes: IVA: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G); IVB: (Any T, Any N, M1, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Cutaneous Mature T-Cell and NK-Cell Neoplasm

A group of neoplasms composed of T-lymphocytes with a mature (peripheral/post-thymic) immunophenotypic profile and/or NK-cells affecting the skin.


Refractory Adenocarcinoma

An adenocarcinoma that does not respond to treatment.


EBV-Related Hodgkin Lymphoma

Hodgkin lymphoma that is caused by Epstein-Barr virus infection.


Grade 2 Extraocular Muscle Paresis, CTCAE

Unilateral paresis without double vision


High Grade Pancreatic Intraepithelial Neoplasia

A pancreatic epithelial neoplasia characterized by the presence of papillary and rarely flat architectural patterns with formation of cribriform patterns and luminal necrosis.  Severe dysplasia is present.


Grade 1 Urinary Tract Pain, CTCAE

Mild pain


Intraoperative Hemorrhage, CTCAE

A finding of uncontrolled bleeding during a surgical procedure.


Grade 2 Sore Throat, CTCAE

Moderate pain; limiting instrumental ADL


Grade 1 Outer Ear NOS Intra-Operative Injury, CTCAE


Neonatal Respiratory Insufficiency, AE

An adverse event in a newborn characterized by significant impairment of gas exchange resulting in compensatory breathing efforts and eventually hypoxia and/or hypercarbia. Note: Consider this adverse event for any patient whose respiratory condition deteriorates from baseline. If any specific diagnosis is identified: use diagnosis-specific scale (e.g. respiratory distress syndrome (RDS), pulmonary hemorrhage).


Ileal Ulcer, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the ileum.


Neuroendocrine carcinoma of appendix

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the appendix. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Grade 2 Brain Intra-Operative Injury, CTCAE


Grade 4 Stroke, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Colonic Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Locally Advanced Neuroendocrine Carcinoma

A neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Gallbladder Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Adrenal Insufficiency, CTCAE

A disorder characterized by the adrenal cortex not producing enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency.


Grade 3 Ileus, CTCAE

Severely altered GI function; TPN indicated; tube placement indicated


Grade 4 Disseminated Intravascular Coagulation, CTCAE


Remote Placental Infarction

A focus of necrotic placental parenchyma with marked hyalinization and fibrosis with complete absence of the necrotic chorionic villi, which is frequently more than 7 days of duration.


Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8

Stage IIA includes: (T2, N0, M0, G3); (T2, N0, M0, GX). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Social Circumstances - Other, Specify, CTCAE


Stage IIIB Bladder Cancer AJCC v8

Stage IIIB includes: T1-T4a, N2, N3, M0. T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N2: Multiple regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node metastasis). N3: Lymph node metastasis to the common iliac lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Spine Kyphosis or Lordosis, CTCAE


Grade 3 Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Acquired methemoglobinemia

Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene) and nitrate-rich foods.


Stage I Fallopian Tube Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 5 Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage I Vulvar Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Prolapse of Gastrointestinal Stoma, CTCAE


Stage IV Bladder Cancer AJCC v8

Stage IV includes: IVA: (T4b, N0, M0); (Any T, Any N, M1a); IVB: (Any T, Any N, M1b). T4b: Extravesical tumor invades pelvic wall, abdominal wall. N0: No regional lymph node metastasis. M0: No distant metastasis. M1a: Distant metastasis limited to lymph nodes beyond the common iliacs. M1b: Non-lymph node distant metastases. (AJCC 8th ed.)


Grade 1 Irritability, CTCAE

Mild; easily consolable


Sharp Pain

A sensation of discomfort or distress that is distinct and intensely focused.


Grade 3 Spasticity, CTCAE

Severe increase in muscle tone and increase in resistance through range of motion


Helicobacter Pylori-Related Gastric Adenocarcinoma

An adenocarcinoma that arises from the gastric mucosa and is caused by persistent infection with Helicobacter pylori.


Locally Advanced Transitional Cell Carcinoma

Transitional cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Gastrointestinal Fistula, CTCAE

Invasive intervention indicated


Grade 4 Supraventricular Tachycardia, CTCAE

Life-threatening consequences


Grade 3 Laryngitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 3 Neonatal Convulsion, AE

An adverse event in a newborn characterized by suspected seizures uncontrolled with one anti-seizure drug (recurrence within three days after treatment or requiring two or more anti-seizure drugs).


Grade 1 Lower Gastrointestinal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 3 Gastric Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 Skin Infection with Unknown Absolute Neutrophil Count, CTCAE


Chemical esophagitis

Esophagitis secondary to chemical exposure.


Endocrine disorder arising from mental factors

An endocrine disorder that is caused by abnormal mental function.


Grade 5 Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Recurrent Childhood Oligodendroglioma

The reemergence of oligodendroglioma in childhood after a period of remission.


Grade 4 Personality Change, CTCAE

Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Brachial Plexus Intra-Operative Injury, CTCAE


Grade 4 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

Life-threatening consequences


Glucose Intolerance, CTCAE

A disorder characterized by an inability to properly metabolize glucose.


Familial Testicular Germ Cell Tumor

Germ cell tumor that arises from the testis and is diagnosed in at least two relatives.


Grade 2 Colitis, CTCAE

Abdominal pain; mucus or blood in stool


Grade 2 Neck Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Ileal Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the intestinal contents in the ileum.


Floaters, CTCAE

A disorder characterized by an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens.


Stage II Adult Diffuse Small Cleaved Cell Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Immune System and Related Disorders

A group of non-neoplastic and neoplastic disorders resulting from the deregulation and/or deficiency of immune system functions. It includes autoimmune disorders (e.g., lupus erythematosus, dermatomyositis, rheumatoid arthritis), congenital and acquired immunodeficiency syndromes including the acquired immune deficiency syndrome (AIDS), and neoplasms (e.g., lymphomas and malignancies secondary to transplantation).


Grade 5 Hyperphosphatemia, CTCAE

Death


Grade 1 Bile Duct Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Cervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma

A carcinoma that arises from the cervix and is characterized by the presence of a cervical adenocarcinoma variant and a neuroendocrine carcinoma component.


Phrenic Nerve Palsy Related to Birth

A condition characterized by reduced or absent movement of the ipsilateral diaphragm as a consequence of an injury to the phrenic nerve or its origin in cervical roots 3 through 5 sustained during the birthing process.


Carotid Artery Intra-Operative Injury, CTCAE


Metastatic Malignant Neoplasm in the Visual Pathway

A malignant neoplasm that has spread to the visual pathway from another anatomic site.


Grade 2 Hydrocephalus, CTCAE

Moderate symptoms; intervention not indicated


Grade 4 Somnolence and Depressed Level of Consciousness, CTCAE


Grade 2 Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Advanced Ampulla of Vater Carcinoma

Carcinoma that arises from the ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IVA Bladder Cancer

Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1 : T4b: Tumor invades the pelvic wall, abdominal wall. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M1: Distant metastasis.


Moderately Differentiated Malignant Neoplasm

A neoplasm whose histologic characteristics are intermediate between poorly differentiated and well differentiated.


Refractory Urothelial Carcinoma

Urothelial carcinoma that does not respond to treatment.


Nuclear Cataract Grade 1

A stage of nuclear sclerotic cataract marked by mild yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Grade 4 Genitourinary Stoma Stricture or Stenosis, CTCAE


Grade 2 Thrush, CTCAE

Oral intervention indicated (e.g., antifungal)


Grade 1 Infusion Site Extravasation, CTCAE

Painless edema


Grade 3 Facial Muscle Weakness, CTCAE

Severe symptoms; limiting self care ADL


Paratesticular Endometrioid Tumor

A group of very rare tumors with endometrioid epithelial differentiation arising from the paratesticular structures. It includes benign tumors, borderline tumors (tumors with atypical epithelial proliferation), and malignant tumors (endometrioid adenocarcinomas).


Stage IVA Gestational Trophoblastic Tumor AJCC v7

Stage IVA includes: Any T, M1b, Risk factors: low risk.  M1b: All other distant metastasis.  (AJCC 7th ed.)


Grade 5 Thrombosis or Embolism Vascular Access Related, CTCAE


Refractory Malignant Glioma

Malignant glioma that does not respond to treatment.


Grade 2 Urostomy Obstruction, CTCAE

Symptomatic; dilation or endoscopic repair or stent placement indicated


Childhood Acute Lymphoblastic Leukemia Toronto Guidelines v2, Tier 2

A term that refers to the staging of childhood acute lymphoblastic leukemia according to the tier 2 Toronto childhood cancer staging guidelines v2.


Dry Mouth, CTCAE

A disorder characterized by reduced salivary flow in the oral cavity.


Grade 4 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Bronchus Obstruction and Stenosis, CTCAE


Retinopathy, CTCAE

A disorder involving the retina.


Grade 2 Gallbladder Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Malignant Neoplasm by Grade

A term that refers to the categorization of malignant neoplasm by histologic grade.


Grade 1 Hot Flashes, CTCAE

Mild symptoms; intervention not indicated


Stage IIA Cervical Cancer FIGO 2009

Cervical carcinoma limited to the upper two-thirds of the vagina. (FIGO 2009)


Grade 5 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Perinatal Brain Injury

Injury to the brain of a newborn infant occurring around the time of birth.


Vascular implant infection

An infectious process originating from an implanted vascular device.


Renal Hemorrhage, CTCAE

A disorder characterized by bleeding from the kidney.


Opisthorchis viverrini Infection

An infection caused by the parasite Opisthorchis viverrini. It results from the ingestion of raw or undercooked food. The clinical features vary from mild to severe and include gastrointestinal symptoms, anorexia, weight loss, hepatomegaly, and cholangitis. Patients are at an increased risk of developing cholangiocarcinoma.


Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Fallopian Tube Undifferentiated Carcinoma

The reemergence of fallopian tube undifferentiated carcinoma after a period of remission.


Grade 4 Sinus Intra-Operative Injury, CTCAE


Activated Partial Thromboplastin Time Prolonged, CTCAE

A finding based on laboratory test results in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment.


Grade 5 CNS Cerebrovascular Ischemia, CTCAE


Conjunctival Lymphangioma

A lymphangioma that arises from the conjunctiva.


perinatal respiratory distress

A pathological increase in the effort and frequency or breathing movements during the perinatal period.


Castleman Disease, Plasma Cell Type

Castleman disease characterized by the presence of prominent hyalinized vessels in the germinal centers and prominent sheets of plasma cells in the interfollicular areas.


Grade 3 Lip Or Perioral Area Intra-Operative Injury, CTCAE


Vaso-Occlusive Crisis in Sickle Cell-SS Disease

Sickle cell-SS disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.


Grade 2 Neonatal Convulsion, AE

An adverse event in a newborn characterized by suspected seizures controlled with one anti-seizure drug (no recurrence within three days after treatment).


Grade 4 Vaginal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


CALLA Positive Lymphoblastic Leukemia

Acute lymphoblastic leukemia which is positive for the common acute lymphoblastic leukemia antigen.


Grade 3 Leukoencephalopathy Radiographic Findings, CTCAE


Movements Involuntary, CTCAE

A disorder characterized by uncontrolled and purposeless movements.


Gastric Mixed Adenocarcinoma

An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of both glandular and poorly cohesive malignant cellular components.


Grade 2 Postoperative Thoracic Procedure Complication, CTCAE

Extubated within 24-72 hrs postoperatively


Grade 2 Rectal Mucositis, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Grade 3 Lymph Leakage, CTCAE

Severe symptoms; invasive intervention indicated


Liposarcoma non-metastatic

Liposarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Non-Neoplastic Disorder

Any disorder other than abnormal tissue growth resulting from uncontrolled cell proliferation.


Stage II Ampulla of Vater Neuroendocrine Tumor AJCC v8

Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading through the sphincter of Oddi into duodenal submucosa or muscularis propria, or measuring more than 1 cm. T3: Tumor invading the pancreas or peripancreatic adipose tissue. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Locally Advanced Midgut Neuroendocrine Tumor

A midgut neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Genitourinary Stoma Hemorrhage, CTCAE


Lugano Classification Stage II Bulky Childhood Hodgkin Lymphoma AJCC v8

Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Increased Red Cell Mass

An indication that the portion of total blood volume occupied by erythrocytes in a sample have increased when compared to normal levels or a previous measurement.


Grade 3 Cartilage Intra-Operative Injury, CTCAE


Central Nervous System Vascular Malformations

A congenital abnormality of the arteries and veins that is located in the brain or spina cord, and which may increase the risk of bleeding, possibly resulting in impaired mental or physical function.


Spindle cell nodule

A benign, reactive lesion occurring status post instrumentation; histologic examination demonstrates a fascicular growth pattern of plump or elongated spindle cells infiltrating the wall of an organ without atypia or necrosis.


Grade 2 Ileal Stenosis, CTCAE

Symptomatic; altered GI function


Grade 3 Duodenal Obstruction, CTCAE

Hospitalization indicated; invasive intervention indicated


Recurrent Male Reproductive System Carcinoma

The reemergence of a carcinoma that affects the male reproductive system after a period of remission.


Grade 4 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Corneal Infection, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Nonresorbable Material Unretrieved In Body


Locally Advanced Neuroendocrine Neoplasm

A neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Childhood Benign Endocrine Neoplasm

A childhood epithelial neoplasm that arises from an endocrine organ and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Stage IA2 Cervical Cancer AJCC v8

Stage IA2 includes: T1a2, Any N, M0. T1a2: Invasive cervical carcinoma with measured stromal invasion of more than 3.0 mm and not more than 5.0 mm, with a horizontal spread of 7.0 mm or less. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 2 Hirsutism, CTCAE

In women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact


Intracranial Melanoma

A melanoma that arises from the structures within the cranium.


Grade 4 Hepatic Artery Intra-Operative Injury, CTCAE


Chest Pain in Right Third Intercostal Space

The location of the chest pain is within the third intercostal space on the right side.


Adnexitis

Inflammation of the appendages of the uterus.


Grade 5 Bronchopulmonary Hemorrhage NOS, CTCAE


Injury To Jugular Vein, CTCAE

A finding of damage to the jugular vein.


Metastatic Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma that has spread to other anatomic sites.


Grade 5 Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


Vulvar Cancer by AJCC v7 Stage

A term that refers to the staging of vulvar carcinoma according to the American Joint Committee on Cancer, 7th edition.


Genitourinary Cancer

A primary or metastatic malignant neoplasm that affects the genitourinary system.


COVID-19-Associated Thromboembolism

Thromboembolism caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Hemangioblastic Meningioma

An obsolete term referring to hemangiopericytoma of the central nervous system.


Grade 4 Dysphagia, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage IV Gallbladder Cancer AJCC v8

Stage IV includes: IVA: T4, N0-1, M0; IVB: (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invading the main portal vein or hepatic artery or invading two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. N2: Metastases to four or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Recurrent Neuroendocrine Neoplasm

The reemergence of a neuroendocrine neoplasm after a period of remission.


Neuroendocrine Growth Hormone Secretion Abnormality, CTCAE


Grade 3 Depression, CTCAE

Severe depressive symptoms; limiting self care ADL; hospitalization not indicated


Grade 2 Laryngeal Edema, CTCAE

Symptomatic; medical intervention indicated (e.g., dexamethasone, epinephrine, antihistamines)


Loss of BRG1 Protein Expression

An immunohistochemical finding indicating negative staining of tumor cells for BRG1 protein, resulting from the mutation of the SMARCA4 gene.


Grade 4 Vagina Stricture or Stenosis, CTCAE


Obesity-Related Malignant Neoplasm

A malignant neoplasm that occurs in the context of obesity.


Arteritis Infective, CTCAE

A disorder characterized by an infectious process involving an artery.


Decreased Concomitant Drug Level

A reduction in the level of a concomitant drug.


Renal Pelvis and Ureter Cancer by AJCC v7 Stage

A term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 7th edition.


Grade 1 Jejunal Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Adult Acute Basophilic Leukemia

An acute basophilic leukemia occurring in adults.


Grade 4 White Blood Cell Decreased, CTCAE

<1000/mm3; <1.0 x 10e9/L


Benign Genitourinary System Neoplasm

A neoplasm that arises from the genitourinary system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 5 Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Major Visceral Artery Intra-Operative Injury, CTCAE


Grade 5 Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


X-linked dyskeratosis congenita

Dyskeratosis congenita inherited in an X-linked recessive pattern. It is caused by mutations in the DKC1 gene.


Factor I Inactivation

Presence of inactivating antibodies to fibrinogen (factor I) in the blood.


Grade 2 Rectum Stricture or Stenosis, CTCAE


Grade 2 Injection Site Reaction, CTCAE

Pain; lipodystrophy; edema; phlebitis


Grade 3 Hypoalbuminemia, CTCAE

<2 g/dL; <20 g/L


Stage I Pancreatic Cancer AJCC v8

Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Frotteurism

A disorder characterized by recurrent sexual urges, fantasies, or behaviors involving touching the genitals of or rubbing the genitals against a nonconsenting person.


Grade 2 Peristomal Infection with Unknown Absolute Neutrophil Count, CTCAE


Cyst of Skene's duct

A rare benign lesion that arises from the vagina. It is characterized by the presence of squamous epithelial and tubular structures in a fibrovascular stroma.


Radiating Chest Pain in Lower Sternum

The location of the radiating chest pain is in the lower portion of the sternum.


Grade 4 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Renal and perinephric abscess

An abscess that is located both in the kidney and across the renal capsule into the perinephric space.


Grade 5 Intraoperative Gastrointestinal Injury, CTCAE

Death


Unresectable Fallopian Tube Adenocarcinoma

Fallopian tube adenocarcinoma that is not amenable to surgical resection.


Recurrent Platinum-Sensitive Fallopian Tube Carcinoma

The reemergence of platinum-sensitive fallopian tube carcinoma after a period of remission.


Polycythemia Vera, Polycythemic Phase

Polycythemia vera characterized by the proliferation of the erythroid, granulocytic, and megakaryocytic lineages. The peripheral blood shows excess of red blood cells, neutrophilia, and thrombocytosis. The bone marrow is hypercellular for the patient's age.


Grade 4 Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Meningismus, CTCAE

Severe symptoms; limiting self care ADL


Adenocarcinoma in situ in tubulovillous adenoma

A non-invasive adenocarcinoma arising from a tubulovillous adenoma.


Leukoencephalopathy, CTCAE

A disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.


Grade 1 Neonatal Hypotension, AE

An adverse event in a newborn characterized by transient (less than 60 minutes), asymptomatic hypotension; not affecting perfusion; not requiring intervention.


Cystic Trophoblastic Tumor

A rare trophoblastic neoplasm that arises in metastatic sites of testicular mixed germ cell tumors following chemotherapy, or is part of treated or untreated testicular mixed germ cell tumors, or is secondary to either chemotherapy-induced or spontaneous regression of testicular choriocarcinoma. It has also been described in central nervous system post-chemotherapy primary germ cell tumors. It is characterized by the presence of cysts lined by squamoid trophoblastic cells. The cysts are often compressed surrounded by other germ cell components.


Infectious mononucleosis-like post-transplant lymphoproliferative disorder

An early post-transplant lymphoproliferative lesion characterized by immunoblastic proliferation and paracortical expansion as seen in infectious mononucleosis.  There is architectural preservation of the involved tissues.  Oligoclonal or monoclonal cellular populations have been detected in a small number of cases.  In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion.


Grade 4 Tracheostomy Site Bleeding, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Dry Eye, CTCAE

Asymptomatic; clinical or diagnostic observations only; symptoms relieved by lubricants


Recurrent Myxoid Liposarcoma

The reemergence of myxoid liposarcoma after a period of remission.


Stage II Gastric Cancer AJCC v6

Stage II includes: (T1, N2, M0), (T2a/b, N1, M0), (T3, N0, M0).  T1: Tumor invades lamina propria or submucosa. T2: Tumor invades muscularis propria or submucosa.  T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa.  T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. N1: Metastasis in 1 to 6 regional lymph nodes. Metastasis in 7 to 15 regional lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.)


Cystic Oncocytic Neoplasm

An oncocytoma with cystic degenerative changes.


Grade 1 Hypertrichosis, CTCAE

Increase in length, thickness or density of hair that the patient is either able to camouflage by periodic shaving or removal of hairs or is not concerned enough about the overgrowth to use any form of hair removal


Decreased Drug Half Life

Decreased period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.


Photosensitivity, CTCAE

A disorder characterized by an increase in sensitivity of the skin to light.


Grade 2 Hypothermia, CTCAE

35->32 degrees C; 95->89.6 degrees F


Cervix Infection with Unknown Absolute Neutrophil Count, CTCAE


Sarcoma by FNCLCC Grade

Grading of sarcomas according to the French Federation of Cancer Centers Sarcoma Group (FNCLCC). This sarcoma grading system is based on three factors: differentiation, mitotic count, and tumor necrosis. The scores for each factor are added to determine the grade (1 to 3) for the sarcoma.


Grade 1 Delirium, CTCAE

Mild acute confusional state


Compound nevus

A nevus composed of neoplastic melanocytes that infiltrate both the epidermis and the dermis.


Hodgkin's disease mixed cellularity stage I supradiaphragmatic


Unresectable Gallbladder Carcinoma

A carcinoma that arises from the gallbladder and it is not amenable to surgical resection.


Cecum Perforation, CTCAE

Cecum Perforation that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


Elevated Serum CA 27-29 Tumor Antigen Levels


Intraoperative Pain

Pain occurring during a surgical operation.


Stage IIIA Cutaneous Melanoma AJCC v7

Stage IIIA includes: (T1-4a, N1a, M0); (T1-4a, N2a, M0).  T1-4a: Non-ulcerated cutaneous melanoma of any thickness.  N1a: Cutaneous melanoma with micrometastasis in one regional lymph node.  N2a: Cutaneous melanoma with micrometastases in 2-3 regional lymph nodes.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Sustained Ventricular Arrhythmia Related to COVID-19

Ventricular tachycardia or ventricular fibrillation lasting greater than or equal to 30 seconds, or requiring direct current cardioversion (DCCV) in a patient with probable or confirmed acute COVID-19.


Breast Columnar Cell Hyperplasia with Atypia

A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by more than two layers of columnar epithelial cells.  Cytologic atypia is present.  Prominent apical cytoplasmic snouts and intraluminal secretions are also present.


Grade 3 Cervix Intra-Operative Injury, CTCAE


Grade 5 Chronic Kidney Disease, CTCAE

Death


Nail Changes, CTCAE 5.0

A disorder characterized by a change in the nails.


Resectable Liposarcoma

Liposarcoma that is amenable to surgical resection.


Stage IIIC Testicular Cancer AJCC v8

Stage IIIC includes: (Any pT/TX, N1-3, M0, S3); (Any pT/TX, Any N, M1a, S3); (Any pT/TX, Any N, M1b, Any S). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. M1b: Testicular cancer with non-pulmonary visceral metastases. S3: LDH more than 10 x N or hCG (mlU/mL) more than 50,000 or AFP (ng/mL) more than 10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Recurrent Adult Acute Lymphoblastic Leukemia

The reemergence of acute lymphoblastic leukemia in adults after a period of remission.


Grade 3 Hypophysitis, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 5 Cranial Nerve V Neuropathy, CTCAE


Biliary Intraepithelial Neoplasia-1

Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial atypia.


Grade 4 Joint Intra-Operative Injury, CTCAE


Grade 4 Ileal Perforation, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Cranial Nerve XI Intra-Operative Injury, CTCAE


Primary Graft Failure After Hematopoietic Cell Transplantation

Failure of initial engraftment of donor hematopoietic cells.


Refractory Aggressive NK-Cell Leukemia

Aggressive NK-cell leukemia that is resistant to treatment.


Grade 2 Malaise, CTCAE

Uneasiness or lack of well being limiting instrumental ADL


Grade 3 Spinal Fracture, CTCAE

Severe back pain; hospitalization or intervention indicated for pain control (e.g., vertebroplasty); limiting self care ADL; disability


Grade 1 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Grade 5 Peritoneal Necrosis, CTCAE

Death


Cystitis Noninfective, CTCAE

A disorder characterized by inflammation of the bladder which is not caused by an infection of the urinary tract.


Grade 5 Intraoperative Splenic Injury, CTCAE

Death


Factor VIII Inactivation

Presence of inactivating antibodies to factor VIII in the blood.


Peritoneal Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the peritoneum.


Grade 3 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Upper Respiratory Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Chest Pain in Sternum

The location of the chest pain is in the middle of the anterior wall of the thorax, bounded by the clavicles, above, and with the cartilages of the first seven ribs, along the sides.


Scrotal Infection

A bacterial, fungal or viral infectious process affecting the scrotum.


Tubular adenoma of breast

A benign, well circumscribed neoplasm that arises from the breast.  It is composed entirely of tubular structures that contain epithelial and myoepithelial cells.


Stage IVA Gallbladder Cancer AJCC v7

Stage IVA includes: T4, N0-1, M0. T4: Tumor invades the main portal vein or hepatic artery, or invades two or more extrahepatic organs or structures.  N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. M0: No distant metastasis.  (from AJCC 7th Ed.)


Ocular surface squamous neoplasia

An umbrella term that comprises the spectrum of squamous neoplasms of the conjunctiva, ranging  from low-grade squamous intraepithelial neoplasia to invasive conjunctival squamous cell carcinoma.


Urethritis Cystica and Glandularis

A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by urothelial cells and metaplastic glandular cells.


Grade 1 Skin Hypopigmentation, CTCAE

Hypopigmentation or depigmentation covering <10% BSA; no psychosocial impact


Grade 5 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Outer Ear Pinna Intra-Operative Injury, CTCAE


Intraocular Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that occurs in the intraocular area.


Congenital spondylolysis of lumbosacral region

A defect in the pars interarticularis of the vertebral arch of a lumbar or sacral vertebra that is present at the time of birth.


Grade 1 Bronchospasm and Wheezing, CTCAE


Chronic Phase Primary Myelofibrosis

Primary myelofibrosis characterized by the presence of less than 10% blasts in the peripheral blood or bone marrow.


Advanced NUT Carcinoma

NUT carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Immature Granulocytic Sarcoma

A granulocytic sarcoma composed of myeloblasts and promyelocytes (WHO 2001).


Foreign body in genitourinary tract

Extraneous material located within the genital and urinary organs.


Staphylococcal osteomyelitis

Osteomyelitis resulting from an infection with Staphylococcus.


Non-Neoplastic Lacrimal System Disorder

A non-neoplastic disorder that affects the lacrimal gland and/or the lacrimal drainage system.


Neonatal Rash, AE

An adverse event in a newborn characterized by an eruption in the skin which affects its appearance and/or texture.


Unresectable Fallopian Tube Carcinoma

Fallopian tube carcinoma that is not amenable to surgical resection.


Grade 4 Iron Overload, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Left Ventricular Systolic Dysfunction, CTCAE


Grade 1 Hepatitis Viral, CTCAE

Asymptomatic, intervention not indicated


Childhood Sarcoma

A sarcoma that occurs during childhood.


Grade 3 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Locally Advanced Anal Carcinoma

Anal carcinoma that has spread to nearby tissues or lymph nodes.


Grade 1 Lung Intra-Operative Injury, CTCAE


Rectal Fistula, CTCAE

A disorder characterized by an abnormal communication between the rectum and another organ or anatomic site.


Small Intestine Infection, CTCAE

A disorder characterized by an infectious process involving the small intestine.


Mental disorder due to a general medical condition

A category of psychiatric disorders which are the direct physiologic consequence of a general medical condition.


Necrotising vasculopathy

Disorders of blood vessels characterized by luminal narrowing due to intramural immune deposits.


Liver Dysplastic Nodule

A premalignant neoplastic nodular lesion of the liver that usually measures less than 15 mm.  It is found during microscopic examination of liver tissues, usually in cirrhotic livers.  Based on the degree of atypia, it is classified as low or high grade.


Grade 4 Ascites, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Pathologic Stage III Retinoblastoma AJCC v8

Stage III includes: Any pT, pN1, cM0, Any H. pN1: Regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Grade 2 Uterine Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 5 Cranial Nerve XII Neuropathy, CTCAE


Grade 1 Vaginal Infection, CTCAE

Localized, local intervention indicated


Grade 4 Injury To Superior Vena Cava, CTCAE


Stage I Uterine Corpus Cancer

Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0). T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium or invades less than one-half of the myometrium. T1b: Tumor invades one-half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Central Nervous System Dermoid Cyst

A dermoid cyst arising in the central nervous system.


Grade 2 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Intraoperative Urinary Injury, CTCAE

Partial resection of injured organ/structure indicated


Mild Chronic Inflammation

A chronic inflammatory process characterized by the accumulation of a small number of lymphocytes and plasma cells.


Hypernatremia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood.


Grade 1 Aspartate Aminotransferase Increased, CTCAE

>ULN-3.0 x ULN if baseline was normal; 1.5-3.0 x baseline if baseline was abnormal


Grade 4 Anal Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Traumatic arthropathy

Any arthropathy that is caused by trauma.


Grade 5 Blood and Lymphatic System Disorders - Other, Specify, CTCAE

Death


Locally Advanced Pancreatic Adenocarcinoma

A pancreatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adverse Event Associated with Secondary Malignancy


Ileal Perforation, CTCAE 5.0

A disorder characterized by a rupture in the ileal wall.


Pancreatic Duct Intra-Operative Injury, CTCAE


Grade 2 Vitreous Hemorrhage, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL


Laryngeal Carcinoid Tumor

A rare, well differentiated, low grade neuroendocrine neoplasm that arises from the larynx.


Grade 5 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Anal Sphincter Intra-Operative Injury, CTCAE


Grade 1 Sleep Apnea, CTCAE

Snoring and nocturnal sleep arousal without apneic periods


Grade 4 Face NOS Intra-Operative Injury, CTCAE


Grade 2 Hearing Patients without Baseline Audiogram and Not Enrolled in a Monitoring Program, CTCAE


Grade 4 Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


Skin Ulceration, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the skin.


Grade 2 External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Advanced Neuroendocrine Neoplasm

A neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Systemic Mastocytosis Associated with Germ Cell Tumor

A disorder characterized by systemic infiltration of internal organs by aggregates of neoplastic mast cells and the presence of a co-occurring germ cell tumor.


Grade 4 Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IV Testicular Non-Seminomatous Germ Cell Tumor


Grade 2 Skin Induration, CTCAE

Moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL


Mesonephric-like adenocarcinoma

An exceedingly rare adenocarcinoma that arises from the uterine corpus and ovary and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Adult Acute Megakaryoblastic Leukemia

An acute megakaryoblastic leukemia occurring in adults.


Treatment-sensitive HIV Infection

An infection with human immunodeficiency virus that responds to therapy.


Acute Myeloid Leukemia with del(20q)

Acute myeloid leukemia associated with deletion of the long arm of chromosome 20 [del(20q)].


Deep Penetrating Nevus

A distinctive melanocytic nevus characterized by a sharply demarcated, circumscribed, and usually wedge-shaped configuration, with the base toward the epidermis and the tip toward the reticular dermis and subcutis. It may simulate melanoma both clinically and histologically.


Allergic Rhinitis Including Sneezing Nasal Stuffiness Postnasal Drip, CTCAE


neoplasm of basal ganglia

A benign or malignant neoplasm that affects the basal ganglia.


Grade 1 Atelectasis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Hyperlactemia

Abnormally high level of lactate in the blood.


Coagulation disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Cavernous Angioleiomyoma

A morphologic variant of angioleiomyoma characterized by the presence of markedly dilated vascular channels.


Peri-prosthetic Joint Infection

Infection around an implant following joint replacement.


Grade 3 Urinary Conduit Intra-Operative Injury, CTCAE


Grade 1 Persistent Pulmonary Hypertension of the Newborn, AE

An adverse event in a newborn characterized by technical evidence of increased right ventricular pressures; no clinical symptoms.


Adverse Event Associated with the Kidney and Genitourinary System


Grade 2 Abdominal Distension or Bloating, CTCAE


Grade 2 Nails Intra-Operative Injury, CTCAE


Renal Calculi, CTCAE

A disorder characterized by the formation of crystals/kidney stones in the pelvis of the kidney.


Other Iatrogenic Immunodeficiency-Related Lymphoproliferative Disorders

Lymphoid proliferations or lymphomas that arise in patients treated with immunosuppressive drugs for autoimmune diseases or conditions other than in the post-transplant setting. (WHO 2017)


Grade 3 Testicular Pain, CTCAE

Severe pain; limiting self care ADL


Grade 1 Neuralgia and Peripheral Nerve Pain, CTCAE


adenocarcinoma of urinary tract

A rare carcinoma with pure glandular differentiation arising anywhere in the urinary tract. This group does not include clear cell and endometrioid adenocarcinomas.


Occlusion

Obstruction or a closure of hollow organ, passageway or vessel; also the transient approximation of the edges of a natural opening; imperforation.


Metastatic Childhood Ependymoma by Toronto Guidelines v2

Disease beyond local site (e.g., other lesions in brain or spine or tumor cells in CSF or distant metastases). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Clinical Course of Disease

A term that refers to the nature and/or clinical outcome of a disease (e.g., acute or chronic disease, aggressive or indolent disease, recurrent disease, etc.).


Grade 1 Pulmonary Edema, CTCAE

Radiologic findings only; minimal dyspnea on exertion


Grade 3 Creatinine Increased, CTCAE

>3.0 x baseline; >3.0-6.0 x ULN


Non-serious Adverse Event

Any adverse experience that does not meet the definition of serious. Non-serious adverse events are classified as mild, moderate and severe.


White Matter Injury

Focal areas of necrosis, with or without cysts, and diffuse areas of white matter dysmaturation with maturation arrest of the pre-oligodendroglia cells, located in the cerebral white matter.


Gastric Hodgkin's Lymphoma

An extremely rare Hodgkin lymphoma that arises from the stomach.


Amnesia, CTCAE

A disorder characterized by systematic and extensive loss of memory.


Cervical high grade squamous intraepithelial lesion

A precancerous neoplastic process that affects the cervical squamous epithelium. It is usually associated with human papillomavirus infection. It is classified as cervical squamous intraepithelial neoplasia 2 when there is nuclear atypia in both the upper and lower epithelial layers, mitotic figures are confined to the basal two-thirds of the epithelium, and maturation is present in the upper half of the epithelium. It is classified as cervical squamous intraepithelial neoplasia 3 when there is nuclear atypia and mitotic figures throughout the entire thickness of the epithelium, and maturation is absent or confined to the upper third of the epithelium.


Grade 5 Infusion Related Reaction, CTCAE

Death


Pathologic Stage II Esophageal Adenocarcinoma AJCC v8

Stage II includes: IIA: (T2, N0, M0, G3); (T2, N0, M0, GX); IIB: (T1, N1, M0, Any G); (T3, N0, M0, Any G). T2: Tumor invades the muscularis propria. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


A meningioma that arises within the cranial cavity and results from exposure to radiation.


Astrocytoma, IDH-Wildtype

Astrocytoma lacking mutations in IDH1 or IDH2 genes. It includes diffuse astrocytoma, IDH-wildtype and anaplastic astrocytoma, IDH-wildtype.


Grade 3 Neonatal Intraventricular Hemorrhage, AE

An adverse event in a newborn characterized by hemorrhage occupying greater than 50% of the ventricle volume; ventricular dilatation greater than 4mm above the 97th percentile; parenchymal venous infarction; requiring temporizing neurosurgical procedure (drain, shunt or reservoir).


Grade 4 Hallucinations, CTCAE

Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Stage IA Ampulla of Vater Cancer AJCC v7

Stage IA includes: T1, N0, M0. T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Locally Advanced Malignant Skin Neoplasm

A malignant neoplasm of the skin that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Fallopian Tube Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 2 Mucosal Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 4 Pericardial Tamponade, CTCAE

Life-threatening consequences; urgent intervention indicated


Myolipoma

A benign extrauterine tumor composed of mature adipocytes and smooth muscle cells.


Glandular odontogenic cyst

A developmental odontogenic cyst with epithelial features that simulate salivary gland or glandular differentiation. (WHO 2017)


Stage IIIA Merkel Cell Carcinoma AJCC v7

Stage IIIA includes: Any T, N1a, M0.  N1a: Micrometastasis in regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th Ed.)


Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Vulvar Tubulovillous Adenoma

An intestinal-type adenoma that arises from the vulva. It is characterized by the presence of a tubulovillous architectural pattern.


Grade 2 Epistaxis, CTCAE

Moderate symptoms; medical intervention indicated (e.g., nasal packing, cauterization; topical vasoconstrictors)


Grade 1 Intraoperative Ocular Injury, CTCAE

Primary repair of injured organ/structure indicated


FIGO Stage IVB Gestational Trophoblastic Tumor


Benign Thalamic Neoplasm

A neoplasm that arises from the thalamus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 5 Tracheal Mucositis, CTCAE

Death


Grade 3 Guillain-Barre Syndrome, CTCAE

Severe symptoms; limiting self care ADL


Nodular and Massive Retinal Gliosis

A spectrum of discrete retinal glial proliferations surrounding blood vessels, ranging in size from small nodules to massive lesions that fill the eye. (WHO 2018)


Conventional Schwannoma

A common, usually encapsulated benign nerve sheath tumor composed of well-differentiated Schwann cells.