Refractory Cytomegalovirus Infection

A cytomegalovirus infection that is resistant to treatment.


Gastrointestinal Stoma Leak, CTCAE

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Grade 5 Malabsorption, CTCAE

Death


Liver Neuroendocrine Tumor G3

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the liver. The Ki-67 index is higher than 20%.


Serum Glutamic Pyruvic Transaminase, CTCAE


AIDS-Related Diffuse Large Cell Lymphoma

A diffuse large cell lymphoma developing in an HIV positive patient.


Grade 2 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Fat Atrophy, CTCAE

Covering >30% BSA; associated with erythema or tenderness; limiting self-care ADL


Grade 2 Oral Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Recurrent Low Grade Endometrial Endometrioid Adenocarcinoma

The reemergence of low-grade endometrial endometrioid adenocarcinoma after a period of remission.


Deletion of Chromosome 22 Associated Meningioma

A meningioma that is associated with deletion of chromosome 22.  This abnormality is the most consistent cytogenetic finding that is detected in meningiomas.


Mouth cyst

A cystic lesion located in the oral cavity.


Grade 5 Conduction Disorder, CTCAE

Death


Stage IB Merkel Cell Carcinoma AJCC v7

Stage IB includes: T1, cN0, M0.  T1: Primary tumor equal or less than 2 cm in size.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Erectile Dysfunction, CTCAE

A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity.


Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IV Ampulla of Vater Cancer AJCC v7

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis.  (from AJCC 7th Ed.)


FEV1, CTCAE

An adverse event marked by a change in FEV1 lung function.


Grade 1 Spermatic Cord Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Bone Schwannoma

A very rare schwannoma of the bone. It is often located in the mandible and is well circumscribed.


Grade 1 Lens Intra-Operative Injury, CTCAE


Esophageal dysplasia

A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma.  Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade.  In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications.  (WHO, 2000)


Melanocytic matricoma

A rare benign pilar tumor with numerous intratumoral pigmented dendritic melanocytes. It typically affects elderly men. The most common location is the head and neck, followed by the trunk and the limbs. It manifests as a small, pigmented, purple or brownish-black papule or nodule. (WHO 2018)


Grade 3 Proptosis and Enophthalmos, CTCAE


Stage II Vaginal Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor invades paravaginal tissues but not to pelvic wall.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Uterine Infection, CTCAE

A disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues.


Precursor T-lymphoblastic lymphoma/leukemia stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in a with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Radiating Chest Pain Along Left Lower Sternal Border

The location of the radiating chest pain is along the left lower sternal border.


Grade 4 Intraoperative Cardiac Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Larynx Obstruction and Stenosis, CTCAE


Childhood Malignant Solid Neoplasm

A malignant solid neoplasm that occurs during childhood.


Suicide Attempt, CTCAE

A disorder characterized by self-inflicted harm in an attempt to end one's own life.


Grade 4 Renal Calculi, CTCAE

Life-threatening consequences; urgent invasive intervention indicated


Infant Acute Undifferentiated Leukemia

An acute undifferentiated leukemia that occurs in infancy.


Grade 1 Prolapse of Gastrointestinal Stoma, CTCAE


Grade 5 Tracheitis, CTCAE

Death


Acute gastritis

Acute inflammation of the stomach.


Periodontal Disease, CTCAE

A disorder in the gingival tissue around the teeth.


Stage IIIA Ampulla of Vater Cancer AJCC v8

Stage IIIA includes: (T1a, N1, M0); (T1b, N1, M0); (T2, N1, M0); (T3a, N1, M0); (T3b, N1, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N1: Metastasis to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Argentaffinoma

A carcinoid tumor that shows atypical characteristics and has borderline malignant potential.


Zonular dehiscence

Rupture of the fibrous strands connecting the ciliary body and the crystalline lens of the eye.


Closed dislocation

A dislocation not complicated by an external wound


Grade 1 Tremor, CTCAE

Mild symptoms


Sickle Beta 0 Thalassemia

A form of sickle cell thalassemia characterized by the absence of hemoglobin A. Patients usually have severe anemia identical to that seen in sickle cell disease.


Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


Unresectable Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma that is not amenable to surgical resection.


Grade 5 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Infant Acute Lymphoblastic Leukemia without MLL Gene Rearrangement

An acute lymphoblastic leukemia without rearrangement of the KMT2A gene that occurs in infancy.


Grade 4 Pneumonitis and Pulmonary Infiltrates, CTCAE


Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Myelodysplastic Syndrome, Not Otherwise Specified without Dysplasia

A premalignant hematologic condition characterized by cytopenia and absence of bone marrow dysplasia. There are less than 5% blasts in bone marrow and less than 2% blasts in peripheral blood.


Malposition of uterus

Orientation of the uterus in an unusual anatomic location or position.


Grade 3 Bronchopulmonary Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 1 Ureter Stricture or Stenosis, CTCAE


Grade 2 Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


Facial Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the face.


Stage III Fallopian Tube Cancer AJCC v8

Stage III includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0; IIIB: T3b, N0/N1, M0; IIIC: T3c, N0/N1, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Type II Total Anomalous Pulmonary Venous Return

Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the coronary sinus.


Grade 5 Other Sexual Reproductive Function, CTCAE


Grade 5 Gallbladder Necrosis, CTCAE

Death


Hepatocyte Nuclear Factor 4-Alpha Hyperinsulinism

Hyperinsulinism due to mutation(s) in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4-alpha. This condition may progress to diabetes later in life.


Grade 1 Paresthesia, CTCAE

Mild symptoms


Lateral developmental cyst of jaw

A developmental odontogenic cyst lined by non-keratinized epithelium, occurring on the lateral aspect or between the roots of erupted teeth. (WHO 2017)


Grade 4 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cystine urolithiasis

Urolithiasis in which the composition of the stones is predominantly cystine.


Renal Pelvis and Ureter Cancer by AJCC v8 Stage

A term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to renal pelvis and ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. It does not apply to renal cell carcinomas (are staged according to the classification for kidney), renal medullary carcinomas (are staged according to the classification for kidney), collecting duct carcinomas (are staged according to the classification for kidney),  lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and mesenchymal tumors (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs). (from AJCC 8th Ed.)


Megacystis - Megaureter

A condition characterized by a large capacity, thin-walled bladder and megaureter(s).


Grade 1 Larynx Obstruction and Stenosis, CTCAE


Grade 3 Vaginal Stenosis and Length, CTCAE


Grade 3 Papulopustular Rash, CTCAE

Papules and/or pustules covering >30% BSA with moderate or severe symptoms; limiting self-care ADL; IV antibiotics indicated


Condyloma Acuminatum with Dysplasia

Condyloma acuminatum that is associated with the presence of dysplastic epithelial changes.


Adenoma, Trabecular

A benign epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern.


Recurrent Adult Brain Neoplasm

The reemergence of brain neoplasm in adulthood after a period of remission.


Grade 4 Hepatitis Viral, CTCAE

Life-threatening consequences; severe decompensated liver function (e.g., coagulopathy, encephalopathy, coma)


Stage 0is Urethral Cancer AJCC v8

Stage 0is includes: Tis, N0, M0. Tis: For male penile urethra and female urethra: Carcinoma in situ. For prostatic urethra: Carcinoma in situ involving the prostatic urethra or periurethral or prostatic ducts without stromal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Stage I Ureter Cancer AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Gingival Pain, CTCAE

Severe pain; inability to aliment orally


Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Retinopathy of Prematurity, AE

An adverse event in a newborn characterized by bilateral retinal detachment and blindness.


Adenocarcinoma in villous adenoma

A non-invasive or invasive adenocarcinoma arising from a villous adenoma.


Advanced Anal Canal Squamous Cell Carcinoma

Anal canal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IB Osteosarcoma AJCC v7

Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


FIGO Stage IIIA Gestational Trophoblastic Tumor


Grade 4 Neonatal Respiratory Distress Syndrome, AE

A respiratory distress adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; requiring urgent care change (e.g. urgent intubation).


Paratesticular Clear Cell Adenocarcinoma

An exceedingly rare adenocarcinoma that arises from the paratesticular structures. It is characterized by the presence of columnar, hobnail, and polygonal cells with clear cytoplasm.


Grade 4 Hip Fracture, CTCAE

Life-threatening consequences; symptoms associated with neurovascular compromise


Grade 4 Hypothyroidism, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Non-Cardiac Chest Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 2 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acquired Cataract

Cataract that results from the aging process, an injury, or as a manifestation of a systemic disorder.


Oropharyngeal Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the oropharynx.


Stage IIIC1 Cervical Cancer FIGO 2018

Cervical carcinoma with pelvic lymph node metastasis only. (FIGO 2018)


Recurrent Small Cell Neuroendocrine Carcinoma

The reemergence of small cell neuroendocrine carcinoma after a period of remission.


Grade 1 Gamma-Glutamyl Transpeptidase, CTCAE


Invasive Plasmacytoid Urothelial Carcinoma

Invasive urothelial carcinoma characterized by the presence of malignant cells with plasmacytoid features.


Stage IIA Gastric Cancer AJCC v7

Stage IIA includes: (T3, N0, M0); (T2, N1, M0); (T1, N2, M0). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 3 Injection Site Reaction or Extravasation Changes, CTCAE


Grade 2 Flashing Lights, CTCAE

Limiting instrumental ADL


Death Neonatal, CTCAE

Newborn death occurring during the first 28 days after birth.


Grade 1 Vaginal Dryness, CTCAE

Mild vaginal dryness not interfering with sexual function


Locally Advanced Adenoid Cystic Carcinoma

Adenoid cystic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Ampulla of Vater Hepatoid Adenocarcinoma

A very rare adenocarcinoma that arises from the ampulla of Vater.  It is usually of the intestinal type and is characterized by the presence of malignant polygonal cells with abundant eosinophilic cytoplasm resembling hepatocytes.


Grade 3 Rectal Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Pharyngeal Mucositis, CTCAE

A disorder characterized by ulceration or inflammation involving the mucous membrane of the pharynx.


Stage IA Bone Sarcoma AJCC v7

Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 3 Weight Loss, CTCAE

>=20% from baseline; tube feeding or TPN indicated


Locally Advanced Fallopian Tube Carcinoma

Fallopian tube carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Small Intestinal Perforation, CTCAE 5.0

A disorder characterized by a rupture in the small intestine wall.


Bladder Endometrioid Adenocarcinoma

A rare bladder adenocarcinoma with the histologic characteristics of endometrioid adenocarcinoma of the endometrium.


Lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Metastatic Neuroendocrine Neoplasm

A neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Appendix Tubular Carcinoid

A neuroendocrine tumor that arises from the appendix.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


Grade 2 Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Merkel Cell Carcinoma by AJCC v8 Pathologic Stage

A term that refers to the pathologic staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


Grade 3 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Small Intestinal Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Uterine Anastomotic Leak, CTCAE

Death


Grade 5 Carbon Monoxide Diffusion Capacity, CTCAE


Smoldering Systemic Mastocytosis

Slowly progressive systemic mastocytosis with uncertain prognosis. It is characterized by organomegaly and absence of aggressive disease.


Fibrinogen Decreased

A laboratory test result which indicates decreased levels of fibrinogen in a biological specimen.


Larynx Edema, CTCAE

Laryngeal edema resulting from a known treatment.


Obesity, CTCAE

A disorder characterized by having a high amount of body fat.


Grade 4 Platelet Count Decreased, CTCAE

<25,000/mm3; <25.0 x 10e9/L


Fibrolipoma

A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue.


Stage IIA Testicular Cancer AJCC v8

Stage IIA includes: (Any pT/TX, N1, M0, S0); (Any pT/TX, N1, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Childhood Benign Skin Melanocytic Nevus

A circumscribed proliferation of melanocytes in the skin that occurs during childhood. It is characterized by the absence of atypical or malignant cytological features, and absence of invasive features or metastatic potential.


Adult Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for adult Hodgkin lymphoma based on the Ann Arbor classification criteria.


Grade 2 Localized Edema, CTCAE

Moderate localized edema and intervention indicated; limiting instrumental ADL


Stage IVA Cervical Cancer AJCC v9

Stage IVA includes: T4, Any N, M0. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 1 Peripheral Sensory Neuropathy, CTCAE

Asymptomatic


Prostate Adenocarcinoma with Neuroendocrine Differentiation

An invasive prostate adenocarcinoma characterized by the presence of malignant cells that exhibit neuroendocrine differentiation.


Psychological Dependence

A behavioral pattern characterized by a craving for the mood-altering effects of a drug and an overwhelming preoccupation with obtaining and using the drug.


Grade 3 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Pleura Intra-Operative Injury, CTCAE


Body Fluid Leakage

The loss of any normal body fluid into the surrounding tissue or body cavity.


Grade 1 Lethargy, CTCAE

Mild symptoms; reduced alertness and awareness


Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Children's Oncology Group (COG) Protocol

A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol. It is based on findings at surgery for patients who have not received chemotherapy prior to surgery. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 1 Haptoglobin Decreased, CTCAE

<LLN


Congenital postural scoliosis

Abnormal sideways curvature of the spine that is present at birth.


Grade 4 Seizure, CTCAE

Life-threatening consequences; prolonged repetitive seizures


Grade 5 Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Bronchopulmonary Hemorrhage, CTCAE

A disorder characterized by bleeding from the bronchial wall and/or lung parenchyma.


Grade 3 Pain of Skin, CTCAE

Severe pain; limiting self care ADL


Eye Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the eye.


Grade 3 Other Growth and Development, CTCAE


Grade 1 Scrotal Infection, CTCAE

Localized, local intervention indicated


Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intestinal Stoma Prolapse

An intestinal stoma complication characterized by protrusion of the intestine above the abdominal surface.


Rhabdomyolysis Related to COVID-19

Rhabdomyolysis in a patient with probable or confirmed acute COVID-19.


Cellular Blue Nevus

A blue nevus characterized by a multinodular cellular infiltrate with a dumb-bell architecture occupying the reticular dermis. The cellular infiltrate often extends into the subcutaneous tissue. The cellular infiltrate is composed of spindle-shaped melanocytes with pale cytoplasm alternating with bundles of pigmented spindle-shaped melanocytes. In occasional cases an increased mitotic activity, focal necrosis, and nuclear pleomorphism may be seen. Such cases with atypical features may have an uncertain malignant potential.


Elevated CA19-9

A laboratory test result indicating the presence of an increased level of the tumor-associated antigen (TAA) CA19-9 in a biological sample.


Grade 3 Neonatal Culture Positive Sepsis, AE

An adverse event in a newborn characterized by a positive blood culture positive with severe signs; supportive treatment escalated or initiated.


Grade 3 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Carcinoma in the Peritoneum

A carcinoma that has spread to the peritoneum from an adjacent or distal anatomic site.


Laryngitis, CTCAE

A disorder characterized by an inflammatory process involving the larynx.


Grade 3 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Clinical Stage IV Retinoblastoma AJCC v8

Stage IV includes: Any cT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Refractory Rare Malignant Solid Neoplasm

A rare malignant solid neoplasm that is resistant to treatment.


Stage I Renal Pelvis and Ureter Cancer AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent Endometrial Transitional Cell Carcinoma

The reemergence of endometrial transitional cell carcinoma after a period of remission.


Refractory Low Grade Glioma

Low grade glioma that is resistant to treatment.


Oxyntic Gland Adenoma

A benign epithelial neoplasm composed of columnar cells with differentiation to chief cells, parietal cells, or both, with a high rate of progression to adenocarcinoma (submucosal invasion). (WHO 2019)


Adult Non-T Non-B Acute Lymphoblastic Leukemia

Non-T non-B acute lymphoblastic leukemia that occurs during adulthood.


Stage IIB Digestive System Neuroendocrine Tumor AJCC v7

Stage IIB includes: T3, N0, M0.  T3: Stomach: tumor penetrates subserosa; jejunum/ileum: tumor invades through the muscularis propria into subserosal tissue without penetration of overlying serosa or invades into non-peritonealized tissues; ampulla/duodenum: tumor invades pancreas or retroperitoneum or into non-peritonealized tissues; colon or rectum: tumor invades through the muscularis propria into the subserosa, or into non-peritonealized pericolic or perirectal tissues. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Non-Obstructed Non-Refluxing Megaureter

A megaureter in which there is no obstruction at the ureterovesical junction and no vesicoureteral reflux.


Hodgkin's disease nodular sclerosis stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Resectable Melanoma

Melanoma that is amenable to surgical resection.


Grade 2 Joint Infection, CTCAE

Localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral); needle aspiration indicated (single or multiple)


Grade 2 White Blood Cell Decreased, CTCAE

<3000-2000/mm3; <3.0-2.0 x 10e9/L


Endometrial Endometrioid Adenocarcinoma with an Undifferentiated Carcinomatous Component

A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with undifferentiated malignant cells.


Stage III Gastric Neuroendocrine Tumor AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Suicidal Ideation, CTCAE

Specific plan to commit suicide without serious intent to die which may not require hospitalization


Lugano Classification Stage I Childhood Hodgkin Lymphoma AJCC v8

Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Creatinine Increased, CTCAE

>1.5-3.0 x baseline; >1.5-3.0 x ULN


Myeloproliferative Neoplasm, BCR-ABL1 Negative

A myeloproliferative neoplasm characterized by the absence of Philadelphia chromosome and BCR-ABL1 fusion gene expression. This group includes polycythemia vera, essential thrombocythemia, and primary myelofibrosis.


Stage IB2 Cervical Cancer

Stage IB2 includes: T1b2, N0, M0.  T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


High Grade Esophageal Glandular Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal glandular epithelium.


Grade 1 Urticaria, CTCAE

Urticarial lesions covering <10% BSA; topical intervention indicated


Grade 4 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Neonatal Culture Negative Sepsis, AE

An adverse event in a newborn characterized by suspected sepsis with severe signs (e.g. fever, grunting); supportive treatment escalated or initiated.


Grade 4 Lower Gastrointestinal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Mediastinum Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 1 Ear Pain, CTCAE

Mild pain


Passive-Aggressive Personality Disorder

A disorder characterized by a pattern of indirect expression of hostility, including negativistic attitudes and passive resistance to demands for adequate performance in social and occupational situations.


Grade 5 Hepatitis B Reactivation, CTCAE

Death


Grade 4 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pneumonitis, CTCAE

Severe symptoms; limiting self care ADL; oxygen indicated


Grade 1 Cecal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 1 Investigations - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 3 Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


Adverse Event Attributed to Commercial Product

An indication that an adverse event is causally related to the use of a commercially available product.


Refractory Sarcoma

A sarcoma that does not respond to treatment.


Esophageal mucositis

An inflammatory process affecting the mucous membrane of the esophagus.


Transferase Deficiency Galactosemia

A disorder characterized by the body's inability to metabolize galactose. This type of galactosemia is caused by germline mutations in the GALT gene which leads to the inhibition in the activity of the enzyme galactose-1-phosphate uridyl transferase.


Hip Fracture, CTCAE

A finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken.


Radiating Chest Pain in Back

The location of the radiating chest pain is in the back.


BCOR ITD sarcoma

A group of rare primitive round cell sarcomas characterized by the presence of BCOR internal tandem duplication. This genetic alteration has been described in infantile undifferentiated round cell sarcomas and primitive myxoid mesenchymal tumors of infancy.


Refractory Langerhans Cell Histiocytosis

Langerhans cell histiocytosis that does not respond to treatment.


Refractory Large Cell Neuroendocrine Carcinoma

Large cell neuroendocrine carcinoma that is resistant to treatment.


Mast Cell Leukemia Associated with Another Hematological Neoplasm

Mast cell leukemia associated with another clonal non-mast cell myeloid neoplasm (e.g., myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia).


Grade 1 Bladder Stricture or Stenosis, CTCAE


Extrahepatic bile duct cancer stage I

Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0).  T1: Tumor confined to the bile duct histologically.  T2: Tumor invades beyond the wall of the bile duct.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IIB Prostate Cancer AJCC v8

Stage IIB includes: T1-2, N0, M0, PSA less than 20, Grade Group 2. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. (AJCC 8th ed.)


Ocular Graft Versus Host Disease

Graft versus host disease occurring in the eye.


Liver Neuroendocrine Neoplasm

An extremely rare neoplasm with neuroendocrine differentiation that arises from the liver. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Stage IB Uterine Corpus Cancer AJCC v7

Stage IB includes: T1b, N0, M0.  T1b: Tumor invades one-half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Pancreatobiliary Carcinoma

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater.


Refractory Acute Bilineal Leukemia

Acute bilineal leukemia that is resistant to treatment.


Grade 3 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Endometrial Carcinoma

Endometrial carcinoma that is resistant to treatment


Brain Damage, Chronic

Encephalopathy that is persistent or long-standing in nature.


Grade 5 Cranial Nerve X Neuropathy, CTCAE


Grade 2 Azoospermia, CTCAE

Absence of sperm in ejaculate


Grade 2 Dental Caries, CTCAE

Dental caries involving the root


Grade 1 Salivary Gland Intra-Operative Injury, CTCAE


Disorder by Site

A term that refers to the classification of a disorder according to the anatomic site that is involved in the pathologic process.


Grade 1 Prostate Intra-Operative Injury, CTCAE


Grade 3 Urinary Retention, CTCAE

Elective invasive intervention indicated; substantial loss of affected kidney function or mass


Jejunal fistula

An abnormal communication between the jejunum and another organ or cavity.


Locally Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma

Extrapulmonary large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 1 Stoma Pulmonary Hemorrhage, CTCAE


Malignant Lymphoma Follicular, Large Noncleaved Cell Type


Symmetric Chest Appearance

Inspection of the region of the anterior surface of the chest and epigastrium reveals an approximate correspondence of form and constituent configuration on opposite sides of a vertical central dividing line.


Esophageal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Postnasal Drip, CTCAE

A disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing.


Childhood Fibrillary Astrocytoma

A fibrillary astrocytoma that occurs during childhood.


Grade 1 Vagina Intra-Operative Injury, CTCAE


Grade 1 Fecal Incontinence, CTCAE

Occasional use of pads required


Grade 5 Stomach Stricture or Stenosis, CTCAE


Cervical Florid Reactive Lymphoid Hyperplasia

A dense, superficial benign lymphoid cell proliferation in the cervix. It almost always occurs in premenopausal women. It is composed of a mixture of large and small lymphocytes including immunoblasts. Plasma cells and neutrophils are also present. Immunohistochemical studies reveal a mixture of B and T lymphocytes, and polytypic plasma cells.


Metastatic malignant neoplasm to ureter

A malignant neoplasm that has spread to the ureter from another anatomic site.


Lugano Classification Stage IE Hodgkin Lymphoma AJCC v8

Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Resectable Dedifferentiated Liposarcoma

Dedifferentiated liposarcoma that is amenable to surgical resection.


Grade 3 Gastrointestinal Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Dysphagia, CTCAE

Symptomatic, able to eat regular diet


Grade 1 Small Intestinal Mucositis, CTCAE

Asymptomatic or mild symptoms; intervention not indicated


Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Refractory Fallopian Tube Carcinoma

Fallopian tube carcinoma that is resistant to treatment.


Grade 2 Neonatal Epileptic Seizure, AE

An adverse event in a newborn characterized by electroencephalogram (EEG)-proven seizures that are controlled with one anti-seizure drug (no recurrence within three days after treatment).


Venous Thrombosis Related to Vascular Access Complication

The formation of a thrombus in the vein as a direct result of an activity associated with vascular access.


Adult Epithelioid Hemangioendothelioma

An epithelioid hemangioendothelioma that occurs during adulthood.


Radial scar

A benign breast lesion characterized by the presence of fibrosis with stellate appearance in the parenchyma.  The lesions are often multiple and bilateral.  Grossly, the lesions are irregular and firm and resemble carcinoma.  Microscopically, the stellate lesions are composed of dense, hyalinized collagen.  Entrapped in the collagen are tubules.  There is no evidence of cytologic atypia.


Non-Encapsulated Neoplasm

A neoplasm that is non-capsulated.


Tracheal Hemorrhage, CTCAE

A disorder characterized by bleeding from the trachea.


Cranial Nerve Injuries

Injury to, or disease of, the cranial nerve


Grade 3 Insomnia, CTCAE

Severe difficulty in falling asleep, staying asleep or waking up early


Grade 4 Spermatic Cord Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Grade 1 Blood Bilirubin Increased, CTCAE

>ULN-1.5 x ULN if baseline was normal; > 1.0-1.5 x baseline if baseline was abnormal


Human Papillomavirus-Related Vaginal Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the vagina and is caused by human papillomavirus infection.


Adnexal mass

An abnormal growth in the ovary, fallopian tube, or surrounding connective tissue.


Grade 3 Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Periodontal Disease, CTCAE

Spontaneous bleeding; severe bone loss with or without tooth loss; osteonecrosis of maxilla or mandible


Grade 4 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Grade 2 Urticaria, CTCAE

Urticarial lesions covering 10-30% BSA; oral intervention indicated


Non-ischemic Stroke

Any stroke that is not related to an obstructed blood vessel.


Recurrent Malignant Supratentorial Neoplasm

The reemergence of a malignant supratentorial neoplasm after a period of remission.


Grade 4 Ileum Stricture or Stenosis, CTCAE


Recurrent Childhood Anaplastic Astrocytoma

The reemergence of anaplastic astrocytoma in childhood after a period of remission.


Miniature Adult Form of AHC

An autosomal recessive or sporadic form of adrenal hypoplasia congenita frequently associated with central nervous system anomalies including anencephaly and pituitary defects. Histologically the adrenal gland is distinguished by the absence of fetal adrenal cortex and the presence of a small amount of normal, permanent adult adrenal cortex.


Congenital Coronary Artery Abnormality

A congenital condition referring to defects of the course and structure of the coronary arteries.


Arterial Injury, CTCAE

A finding of damage to an artery.


Dyspepsia, CTCAE

A disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting.


Grade 4 Rectum Stricture or Stenosis, CTCAE


Adult Benign Cerebellar Neoplasm

A benign neoplasm of the cerebellum occurring in adults.


Esophagitis, CTCAE

A disorder characterized by inflammation of the esophageal wall.


Arachnoiditis and Meningismus and Radiculitis, CTCAE


Endometrial Endometrioid Adenocarcinoma with Small Nonvillous Papillae


Stage IB Bone Cancer AJCC v8

Stage IB includes: (T2, N0, M0, G1 or GX); (T3, N0, M0, G1 or GX). T2: Tumor measuring more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


Grade 2 Urinary Urgency, CTCAE

Limiting instrumental ADL; medical management indicated


Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage III Cervical Cancer AJCC v9

Stage III includes: T3, N0, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Uterine Perforation, CTCAE

A disorder characterized by a rupture in the uterine wall.


Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Uterus Stricture or Stenosis, CTCAE


Grade 1 Spermatic Cord Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Hormone Receptor Status

An indication of the presence or absence of detection of hormone receptor expression in a sample.


Agenesis

A congenital abnormality resulting in the absence of an anatomical structure.


Grade 5 Iron Overload, CTCAE

Death


Grade 3 Hypoxic Ischemic Encephalopathy, AE

An adverse event in a newborn characterized by moderate clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event; meeting criteria for therapeutic hypothermia.


Stage I Cervical Cancer FIGO 2018

The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2018)


Grade 2 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Salivary Duct Inflammation, CTCAE

Slightly thickened saliva; slightly altered taste (e.g., metallic)


Grade II Glandular Intraepithelial Neoplasia


Grade 3 Associated with the Teeth, CTCAE


Recurrent Juvenile Myelomonocytic Leukemia

The reemergence of juvenile myelomonocytic leukemia after a period of remission.


An epithelioid hemangioendothelioma that occurs during childhood.


Grade 1 Dysuria, CTCAE

Present


Locally Advanced Osteosarcoma

Osteosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Neonatal Rash, AE

An adverse event in a newborn characterized by diffuse rash and vesicles or limited number of bullae or superficial ulcerations of mucous membranes limited to one site.


Indolent NK-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract

An indolent lymphoproliferative disorder that affects the gastrointestinal tract. The neoplastic lymphocytes have the typical phenotype of NK-cells, are of medium to large size, show mild pleomorphism, and are EBV infection negative. Features that characterize extranodal NK/T-cell lymphomas (e.g., angioinvasion and angiodestruction) are not present.


Grade 4 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IV Extrahepatic Bile Duct Cancer

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th ed.)


Grade 2 Erectile Dysfunction, CTCAE

Decrease in erectile function (frequency/rigidity of erections), erectile intervention indicated, (e.g., medication or mechanical devices such as penile pump)


Methotrexate-Associated Lymphoma

A non-Hodgkin or Hodgkin lymphoma that develops in patients who are immunosuppressed with methotrexate.


Transitory tachypnea of newborn

A respiratory disorder characterized by higher than normal respiratory rates among premature and cesarean section delivered neonates whose lungs have not fully matured. The cause is often excess fluid in the lungs, and resolution is aided by supplemental oxygen and sometimes, antibiotics.


Grade 4 Neonatal Rash, AE

An adverse event in a newborn characterized by extensive or generalized bullous lesions or ulceration of mucous membranes involving two or more distinct mucosal sites or Stevens-Johnson syndrome or toxic epidermal necrosis.


Grade 1 Nasal Cavity Intra-Operative Injury, CTCAE


Systemic lupus erythematosus, childhood onset

Systemic lupus erythematosus (SLE) diagnosed in individuals under the age of eighteen. Children frequently have multi-organ involvement and acute disease onset. Symptoms include fever, arthritis, skin lesions, anemia, and fatigue.


Grade 5 Other Constitutional Symptoms, CTCAE


Benign neoplasm of female breast

A neoplasm that arises from the breast in females and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 3 Neuralgia, CTCAE

Severe pain; limiting self care ADL


Eye Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Grade 5 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Intraoperative Musculoskeletal Injury, CTCAE

Partial resection of injured organ/structure indicated


Grade 4 Menorrhagia, CTCAE

Life-threatening consequences; urgent intervention indicated


Early T Precursor Lymphoblastic Leukemia/Lymphoma

T lymphoblastic leukemia/lymphoma in which the blasts have unique immunophenotypic and genetic characteristics suggesting only limited early T-cell differentiation.


Posterior Fossa Neoplasm

A neoplasm that arises from the posterior cranial fossa. Examples include meningiomas and medulloblastomas.


Grade 4 Necrotizing Enterocolitis, AE

A necrotizing enterocolitis adverse event in a newborn characterized by bowel perforation (pneumoperitoneum)(modified Bell stage IIIB); shock, disseminated intravascular coagulation (DIC), combined respiratory and metabolic acidosis (modified Bell stage IIIA); urgent major care change indicated.


Urine Discoloration, CTCAE

A disorder characterized by a change in the color of the urine.


Grade 1 Tendon Intra-Operative Injury, CTCAE


Recurrent Atypical Meningioma

The reemergence of atypical meningioma after a period of remission.


Grade 1 Oral Cavity NOS Intra-Operative Injury, CTCAE


Grade 1 Anal Pain, CTCAE

Mild pain


Transient Myocardial Dysfunction of Newborn

A condition in a newborn characterized by a temporary decrease in right ventricular and/or left ventricular output.


Hutch diverticulum

A congenital out pouching of the bladder involving the ureteral hiatus.


Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Pulmonary Hypertension, CTCAE

Life-threatening airway consequences; urgent intervention indicated (e.g., tracheotomy or intubation)


Grade 3 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Radiculitis, CTCAE

Moderate symptoms; medical intervention indicated; limiting instrumental ADL


Spermatic Cord Stricture or Stenosis, CTCAE


Obesity-Associated Insulin Resistance

Insulin resistance associated with obesity, which may be attributed in part to impaired insulin signaling in target tissues, or impaired insulin-stimulated glucose transport due to reduced expression of the glucose transporter protein 4.


Childhood Non-Ossifying Fibroma

A non-ossifying fibroma that occurs during childhood.


Clinical Stage IIC Cutaneous Melanoma AJCC v8

Stage IIC includes: T4b, N0, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Lymphoma, EBV-associated

Lymphoma that is caused by Epstein-Barr virus infection.


Grade 2 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage I Anal Canal Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Increased Time To Peak Drug Blood Concentration

Increased period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.


Cutaneous Malignant Melanoma 2

An autosomal dominant genetic disorder caused by mutations in the CDKN2A gene, encoding cyclin-dependent kinase inhibitor 2A. The condition is characterized by cutaneous malignant melanoma associated with this genetic alteration.


Stage IVA Appendix Carcinoma AJCC v8

Stage IVA includes: (Any T, N0, M1a); (Any T, Any N, M1b, G1). N0: No regional lymph node metastasis. M1a: Intraperitoneal acellular mucin, without identifiable tumor cells in the disseminated peritoneal mucinous deposits. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. G1: Well differentiated. (AJCC 8th ed.)


Grade 4 Vas Deferens Stricture or Stenosis, CTCAE


Lipase Increased, CTCAE

A finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen.


Chest Pain in Lower Sternum

The location of the chest pain is in the lower portion of the sternum.


Follicle Stimulating Hormone Receptor Deficiency

Reduced or absent function of the receptor for follicle stimulating hormone associated with a mutation in the FSHR gene.


Grade 3 Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


Grade 4 Lens Intra-Operative Injury, CTCAE


Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Pharynx Intra-Operative Injury, CTCAE


Vaginal Obstruction, CTCAE 5.0

A disorder characterized by blockage of vaginal canal.


Adult L2 Acute Lymphoblastic Leukemia

L2 acute lymphoblastic leukemia that occurs during adulthood.


Central Nervous System SMARCB1/INI1-Deficient Tumor

A group of SMARCB1/INI1 deficient tumors that arise from the central nervous system. It includes highly aggressive and slow-growing tumors.


Grade 4 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Intraoperative Respiratory Injury, CTCAE

Primary repair of injured organ/structure indicated


Grade 2 Breast Nipple and Areolar Deformity, CTCAE


Grade 4 Thrombotic Thrombocytopenic Purpura, CTCAE

Life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure)


Grade 5 Thrombosis or Thrombus or Embolism, CTCAE


Grade 5 Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Clinical Stage 0 Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Muscle Intra-Operative Injury, CTCAE


Grade 4 Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malignant Lymphoma by Cell Type (Working Formulation)


Old Burn Scar-Related Cutaneous Melanoma

A cutaneous melanoma that arises in an old burn scar tissue.


Stage I Intermediate Grade Adult Non-Hodgkin's Lymphoma


Vertigo, CTCAE

A disorder characterized by a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo).


Grade 3 Gamma-Glutamyl Transpeptidase, CTCAE


Grade 5 Peritoneal Infection, CTCAE

Death


Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Reactive Vascular Proliferation

A non-neoplastic proliferation of vessels in reaction to a process.


Hepatic Vein Intra-Operative Injury, CTCAE


Recurrent Platinum-Resistant Fallopian Tube Carcinoma

The reemergence of platinum-resistant fallopian tube carcinoma after a period of remission.


Grade 3 Hiccups, CTCAE

Severe symptoms; interfering with sleep; limiting self care ADL


Stage IV Vulvar Cancer AJCC v6

Stage IV includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0); IVB (Any T, Any N, M1).  T4: Tumor invades any of the following: upper urethra bladder mucosa, rectal mucosa, or is fixed to the pubic bone.  N2: Bilateral regional lymph node metastasis.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 6th ed.)


Bladder Flat Urothelial Carcinoma

An in situ or invasive urothelial carcinoma that arises from the bladder wall and does not grow toward the hollow part of the bladder.


Grade 2 Tracheal Obstruction, CTCAE

Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


Grade 2 Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intracranial Myeloid Sarcoma

A myeloid sarcoma that affects the meninges or the cerebral hemispheres.


Grade 2 Feeding Intolerance, AE

An adverse event in a newborn characterized by moderate feeding intolerance; resulting in minor discomfort or alteration of drinking behavior; minor care changes indicated (e.g. feeds withheld).


Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Esophagus Stricture or Stenosis, CTCAE


Grade 4 Other Hemorrhage and Bleeding, CTCAE


High Grade Cervical Intraepithelial Neoplasia

Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes.


Grade 2 Akathisia, CTCAE

Moderate restlessness or increased motor activity; limiting instrumental ADL


Grade 2 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IIIA Vulvar Cancer AJCC v8

Stage IIIA includes: T1-T2, N1, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 3 Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Fibrosarcoma non-metastatic

Fibrosarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Anorectal infection

An infectious process affecting the anal area and the rectum.


Grade 5 Cholecystitis, CTCAE

Death


Grade 4 Uterus Intra-Operative Injury, CTCAE


Unspecified idiopathic peripheral neuropathy

Neuropathy, the cause of which is not known.


Spotty/Minimal Hemorrhage

Small (<3mm) foci of hemorrhage within the tumor.


Grade 4 Confusion, CTCAE

Life-threatening consequences; urgent intervention indicated


Eosinophilia, CTCAE

A disorder characterized by laboratory test results that indicate an increased number of eosinophils in the blood.


Oligometastatic Malignant Solid Neoplasm

A malignant solid neoplasm that has metastasized to a limited number of sites— existing in a state intermediate between localized disease and widespread metastatic disease.


Persistent Oligoarticular Juvenile Idiopathic Arthritis

Oligoarticular juvenile idiopathic arthritis that never involves more than four separate joints after six months.


Locally Advanced Prostate Carcinoma

A prostatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Cervical Neuroendocrine Neoplasm

A neuroendocrine neoplasm that arises from the cervix. This category includes neuroendocrine tumor grade 1, neuroendocrine tumor grade 2, and neuroendocrine carcinoma (small cell and large cell neuroendocrine carcinoma).


Induration or Fibrosis of the Skin and Subcutaneous Tissue, CTCAE


Grade 2 Ascites, CTCAE

Symptomatic; medical intervention indicated


Grade 1 Breast Intra-Operative Injury, CTCAE


Grade 4 Upper Extremity Artery Intra-Operative Injury, CTCAE


Childhood Neuroendocrine Tumor

A neuroendocrine tumor that occurs during childhood.


Locally Advanced Non-Muscle Invasive Bladder Carcinoma

Non-muscle invasive bladder carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Pleural Effusion, CTCAE

A disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort.


Stage IA Uterine Corpus Cancer AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Uterine corpus carcinoma or carcinosarcoma with tumor limited to the endometrium or invading less than half the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Rectal Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the intestinal contents in the rectum.


Grade 3 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 5 Myasthenia Gravis, CTCAE

Death


Pediatric Viral Infection

A viral infection that occurs during infancy, childhood or adolescence.


Grade 4 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Vas Deferens Stricture or Stenosis, CTCAE


Immune Checkpoint Inhibitor-related Myocarditis

Myocarditis associated with the therapeutic use of an immune checkpoint inhibitor.


Meningeal Melanocytoma of Intermediate Grade

A circumscribed meningeal melanocytic neoplasm with bland histological features and increased mitotic activity or invasion of the central nervous system.


Pressing Pain

A sensation of discomfort or distress from excess weight or pressure on a specific anatomical location.


Fetus Small for Gestational Age with Abdominal Circumference Less than Tenth Percentile

A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and whose abdominal circumference falls below the tenth percentile.


Grade 2 Otitis Media, CTCAE

Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Dusky Mucosa

A finding indicating the presence of dark discoloration on the mucosal surface. It is associated with tissue necrosis.


Refractory Abdominal Neuroendocrine Neoplasm

An abdominal neuroendocrine neoplasm that does not respond to treatment.


Grade 4 Arteritis Infective, CTCAE

Life-threatening consequences; urgent intervention indicated


Nasal Cavity Intra-Operative Injury, CTCAE


Grade 3 Uterine Pain, CTCAE

Severe pain; limiting self care ADL


Grade 3 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Vaginal Large Cell Neuroendocrine Carcinoma

A rare, aggressive neuroendocrine carcinoma that arises from the vagina and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli.


Childhood Diffuse Large Cell Lymphoma

A diffuse large cell lymphoma occurring in children.


Recurrent Epstein-Barr Virus-Related Lymphoproliferative Disease with Primary Immunodeficiency

The reemergence of EBV-associated lymphoproliferative disease with primary immunodeficiency after a period of remission.


Retinoblastoma by AJCC v8 Pathologic Stage

A term that refers to the pathologic staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition.


Grade 4 Testes Stricture or Stenosis, CTCAE


Grade 5 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Diffuse Midline Glioma with EZHIP Overexpression

A diffuse midline glioma, H3 K27-altered, characterized by the presence of EZHIP overexpression.


Lymph Node Follicular Hyperplasia

Hyperplasia of the germinal centers resulting in the enlargement of the lymph node.


Latent Infection

A period in which the infection is present in the host without producing overt symptoms.  (from Online Medical Dictionary)


Grade 3 Cardiac Ischemia or Infarction, CTCAE


Grade 4 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Testicular Sclerosing Sertoli Cell Tumor

A rare testicular Sertoli cell tumor characterized by the presence of neoplastic tubules that are surrounded by a dense fibrotic stroma.


Grade 2 Investigations - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 2 Neonatal Sinus Tachycardia, AE

An adverse event in a newborn characterized by persistent sinus tachycardia; no change in age appropriate behavior; requiring minor care changes (e.g. concomitant medication changed).


Grade 2 Pneumonitis, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Grade 1 Epistaxis, CTCAE

Mild symptoms; intervention not indicated


Grade 3 Thromboembolic Event, CTCAE

Urgent medical intervention indicated (e.g., pulmonary embolism or intracardiac thrombus)


Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Elevated Serum CA-125 Tumor Antigen

A finding indicating elevated concentrations of the tumor antigen CA-125 in a blood serum sample.


Grade 1 Social Circumstances - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 2 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Stage IVA Uterine Corpus Cancer AJCC v8

Stage IVA includes: T4, Any N, M0. T4: Uterine corpus carcinoma or carcinosarcoma with tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


Hormone Therapy Refractory Neoplasm

A neoplasm that does not respond to hormone therapy.


Arbovirus hemorrhagic fever

A group of viral illnesses that are vectored by arthropods, and that are characterized by increased susceptibility to bleeding diatheses.


Grade 3 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ovulatory Pain

Painful sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.


Grade 3 Ankle Fracture, CTCAE

Limiting self care ADL; elective operative intervention indicated requiring hospitalization


Grade 2 Generalized Edema, CTCAE

Interfering with instrumental ADLs; oral therapy initiated


Grade 5 Uterine Infection, CTCAE

Death


Urinary Tract Infection, CTCAE

A disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra.


Grade 4 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Locally Advanced Cutaneous Melanoma

Cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Dysphagia, CTCAE

Death


Malignant Intracranial Neoplasm

A malignant neoplasm involving the intracranial space.


Cutaneous Acute Graft versus Host Disease

Skin manifestations of acute graft versus host disease, which typically presents as an erythematous maculopapular rash involving the face, ears, palms, and soles that may spread to the trunk and evolve to erythroderma.


Chronic Active EBV Infection of T-and NK-Cell Type, Systemic Form

An EBV-positive T-cell/NK-cell lymphoproliferative disorder characterized by repeated infectious mononucleosis-like symptoms, a very high titer of anti-EBV antibodies, and high levels of Epstein-Barr virus nucleic acids. Patients often develop progressive cellular and humoral immunodeficiency with pancytopenia and hypogammaglobulinemia.


Deep Venous Thrombosis Related to COVID-19

Deep vein thrombosis in a patient with probable or confirmed acute COVID-19.


Clinical Stage IA Cutaneous Melanoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Urinary Tract NOS Intra-Operative Injury, CTCAE


Breast Neurofibroma

A neurofibroma that arises from the breast.


Grade 2 Vasculitis, CTCAE

Moderate symptoms, medical intervention indicated


Gastric Fistula, CTCAE

A disorder characterized by an abnormal communication between the stomach and another organ or anatomic site.


Diarrhea, CTCAE

A disorder characterized by an increase in frequency and/or loose or watery bowel movements.


Advanced Cutaneous Melanoma of the Extremity

Cutaneous melanoma of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Superior Vena Cava Intra-Operative Injury, CTCAE


Grade 4 Hydrocephalus, CTCAE

Life-threatening consequences; urgent intervention indicated


Radiation-induced fibrous mediastinitis

Fibrous mediastinitis arising due to radiation therapy.


Grade 1 Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


Grade 3 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Delirium, CTCAE

Moderate and acute confusional state; limiting instrumental ADL


Recurrent Extrapulmonary Small Cell Neuroendocrine Carcinoma

The reemergence of extrapulmonary small cell neuroendocrine carcinoma after a period of remission.


Sessile Serrated Adenoma/Polyp

Polyps that arises from the large intestine and the appendix. They are characterized by the presence of serrated glands and the absence of generalized dysplasia.


Intrapartum Uterine Rupture

An acute symptomatic tearing of the uterine wall after the onset of labor.


Childhood Acute Myeloid Leukemia with Minimal Differentiation

An acute myeloid leukemia with minimal differentiation occurring in children.


Perforation of organ

A rupture in an organ(s) due to traumatic or pathologic processes.


Stage III Adult Diffuse Small Cleaved Cell Lymphoma

Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Childhood Central Nervous System Neoplasm

A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in children.  Representative examples include posterior fossa astrocytoma, optic pathway glioma, medulloblastoma, ependymoma, and craniopharyngioma.


Grade 3 Psychosis, CTCAE

Severe psychotic symptoms (e.g., paranoid, extreme disorganization); hospitalization not indicated; new onset


Grade 3 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Recurrent Adnexal Carcinoma

The reemergence of adnexal carcinoma after a period of remission.


Metastatic Adnexal Carcinoma

Adnexal carcinoma that has spread from the original site of growth to other anatomic sites.


Regimen-Limiting Toxicity

A side effect of a drug or other treatment that is serious enough to necessitate a dose modification.


Grade 4 Cranial Nerve XII Neuropathy, CTCAE


Grade 1 Blood and Lymphatic System Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 3 Malaise, CTCAE

Uneasiness or lack of well being limiting self-care ADL


Musculoskeletal toxicity

A toxicity that impairs or damages the musculoskeletal system.


Grade 3 Irritability, CTCAE

Severe abnormal or excessive response; limiting self care ADL; inconsolable; medical or psychiatric intervention indicated


Grade 3 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Injury of diaphragm with open wound into cavity

Trauma to  the diaphragm associated with a break in the tissue that extends into the thoracic cavity.


Stage IIB Osteosarcoma AJCC v7

Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 4 Postoperative Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Head Mass

An abnormal growth located on the head.


Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Lip Or Perioral Area Intra-Operative Injury, CTCAE


Defective T-Cell Receptor Signaling

An indication that T-cell receptor (TCR)-dependent signaling pathways in a immunologic sample are compromised. TCR signaling defects lead to impaired development of T-lymphocytes and are usually caused by deletion or loss of function mutations affecting one or more proteins involved in TCR-dependent signaling pathways, including the subunits of the TCR complex.


Pancreatic Cancer by AJCC v8 Stage

A term that refers to the staging of exocrine pancreatic cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to pancreatic ductal adenocarcinoma, acinar cell carcinoma, intraductal papillary mucinous neoplasm with associated invasive carcinoma, intraductal tubulopapillary neoplasm with associated invasive carcinoma, colloid carcinoma, mucinous cystic neoplasm with associated invasive carcinoma, solid pseudopapillary neoplasm, large cell neuroendocrine carcinoma, small cell neuroendocrine carcinoma, and pancreatoblastoma. Well-differentiated neuroendocrine tumors are not staged using this staging system. (from AJCC 8th Ed.)


Primary osteosarcoma of bone

A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It usually involves the long bones and predominantly affects adolescents and young adults. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs.


Grade 2 Brachial Plexus Intra-Operative Injury, CTCAE


Grade 3 Neonatal Fever, AE

An adverse event in a newborn characterized by fever, major change in baseline age-appropriate behavior and without resolution to symptomatic treatment.


Grade 4 Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


Chlamydia psittaci infection

A bacterial infection caused by Chlamydophila psittaci. Humans are infected by handling sick birds. The Chlamydiae cause respiratory infection manifests with fever, malaise, cough, dyspnea, sore throat, photophobia and headaches.


Decreased Time To Peak Drug Blood Concentration

Decreased time following drug administration at which the peak drug blood concentration occurs.


Grade 2 Hematosalpinx, CTCAE

Moderate bleeding; medical intervention indicated


Grade 2 Renal and Urinary Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Clinical Test Result

The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition.


Grade 4 Bronchus Obstruction and Stenosis, CTCAE


Stage IVB Cervical Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


Grade 4 Other Sexual Reproductive Function, CTCAE


Neonatal Constipation, AE

An adverse event in a newborn characterized by irregular and infrequent or difficult evacuation of the bowels.


Grade 2 Small Bowel Perforation NOS, CTCAE


Recurrent Adult Diffuse Small Cleaved Cell Lymphoma

The reemergence of adult diffuse small cleaved cell lymphoma after a period of remission.


Phantom Pain Associated with Missing Limb, CTCAE


Adverse Event Attributed to Other Cause

An indication that an adverse event is causally related to an entity that is a not a disease- or research-related process nor a commercial product or investigational new drug (IND).


Advanced Neuroendocrine Tumor

A neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


round cell sarcoma with EWSR1-NFATC2 gene fusion

A group of rare round and spindle cell sarcomas characterized by the presence of EWSR1-NFATC2 gene fusion.


Grade 3 Larynx Intra-Operative Injury, CTCAE


Grade 2 Adrenal Insufficiency, CTCAE

Moderate symptoms; medical intervention indicated


Refractory Gastric Carcinoma

Gastric carcinoma that does not respond to treatment.


Grade 2 Depressed Level of Consciousness, CTCAE

Sedation; slow response to stimuli; limiting instrumental ADL


Solid Pseudopapillary Neoplasm

A low-grade malignant neoplasm that arises from the exocrine pancreas. Rare cases arising from ectopic pancreatic tissue in the ovary have also been described. It is characterized by the presence of uniform cells that form solid and pseudopapillary patterns, cystic changes, and hemorrhage. It usually presents as an encapsulated, solitary, and lobulated mass. It occurs predominantly in young women. Complete removal of the tumor is curative in the majority of cases.


Grade 4 Aortic Injury, CTCAE

Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


IOL dislocation

Displacement of the intraocular lens from the visual axis.


Grade 5 Gallbladder Fistula, CTCAE

Death


Stage IIA1 Cervical Cancer FIGO 2018

Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, less than 4 cm in greatest dimension. (FIGO 2018)


Refractory Giant Cell Glioblastoma

Giant cell glioblastoma that is resistant to treatment.


Grade 1 Hyperkalemia, CTCAE

>ULN-5.5 mmol/L


Genitourinary System Carcinoma

A carcinoma arising from the genitourinary system. Representative examples include kidney carcinoma, bladder carcinoma, prostate carcinoma, endometrial carcinoma, cervical carcinoma, and ovarian carcinoma.


Toothache, CTCAE

A disorder characterized by a sensation of marked discomfort in the tooth.


Grade 5 Ovarian Rupture, CTCAE

Death


Grade 5 Upper Gastrointestinal Hemorrhage, CTCAE

Death


Reproductive System and Breast Disorders - Other, Specify, CTCAE


Grade 1 Injection Site Reaction or Extravasation Changes, CTCAE


Anti-D Hemolytic Disease of the Newborn

A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of antibodies from a mother to the child via the placenta against the D antigen, the most common Rhesus factor.


Non-Neoplastic Thoracic Disorder

A non-neoplastic disorder that affects the thorax and/or the organs of the thoracic cavity.  Representative examples include pleural infection, mediastinitis, pneumonia, and chronic obstructive pulmonary disease.


Splenic Rupture Related to Birth

Disruption of the spleen incurred during delivery.


Regional Urothelial Carcinoma of the Renal Pelvis and Ureter

Urothelial carcinoma of the renal pelvis or ureter that has spread to adjacent tissues and/or regional lymph nodes but not to distant anatomic sites.


Sarcoma of the Extremity

A sarcoma that arises from the soft tissues or bones of the upper or lower extremity.


Grade 2 Visceral Arterial Ischemia, CTCAE

Brief (<24 hrs) episode of ischemia managed medically and without permanent deficit


Fetal Hypoxia

Hypoxia in utero, caused by conditions such as inadequate placental function (often abruptio placentae), preeclamptic toxicity, prolapse of the umbilical cord, or complications from anesthetic administration.


Eye Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 3 Olfactory Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Recurrent Urinary System Carcinoma

Reemergence of a urinary system carcinoma after a period of remission.


Severe Mosquito Bite Allergy

An EBV-positive NK-cell lymphoproliferative disorder characterized by high fever and intense local skin symptoms, including erythema, bullae, ulcers, skin necrosis, and deep scarring following mosquito bites. Patients have NK-cell lymphocytosis in the peripheral blood and an increased risk of developing hemophagocytic syndrome and progressing into overt NK/T-cell lymphoma or aggressive NK-cell leukemia in the longstanding clinical course. (WHO 2017)


Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Uterine Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the uterus.


Grade 2 Ileal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Classical Hodgkin lymphoma type posttransplant lymphoproliferative disorder

A lymphoproliferative disorder that fulfills the criteria for classic Hodgkin lymphoma and arises as a result of post-transplant immunosuppression therapy. It is most often seen in renal transplant patients.


Stage I Gallbladder Cancer AJCC v7

Stage I includes: T1, N0, M0. T1: Tumor invades lamina propria or muscular layer.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Metastatic Digestive System Carcinoma

A carcinoma that arises from the gastrointestinal system and has metastasized to other anatomic sites.


Unresectable Meningioma

A meningioma that is not amenable to surgical resection.


Stage IV Adult Diffuse Large Cell Lymphoma

Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Personality Change, CTCAE

A disorder characterized by a conspicuous change in a person's behavior and thinking.


Childhood Cancer Stage by Toronto Guidelines v2

A term that refers to the staging of childhood cancers following the rules of the Toronto guidelines v2, 2019. The guidelines were developed to address the lack of consistent information on childhood cancer staging in population registries and are not intended to replace staging systems in clinical use. They include a two-tiered approach that provides less detailed criteria for registries with limited resources and/or limited data access (Tier 1) and more detailed criteria for better-resourced registries (Tier 2). They apply to acute lymphoblastic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, neuroblastoma, renal malignant tumors except renal cell carcinoma, rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, malignant bone tumors, retinoblastoma, hepatoblastoma, testicular germ cell tumors, ovarian germ cell tumors, astrocytoma, medulloblastoma and ependymoma. The following changes were noted to the original classification (v1, 2014): a staging system was no longer considered appropriate for acute myeloid leukemia; all renal tumors, with the exception of renal cell carcinomas, should use the endorsed staging systems for Wilms tumor; staging systems for osteosarcoma and Ewing sarcoma were combined into a single recommendation for all malignant bone tumors; a staging system was endorsed for astrocytomas; the S category (serum tumor markers) was confirmed as an integral part of TNM staging for testicular cancer in Tier 2 recommendations; and PRETEXT number was added to Tier 2 recommendations for hepatoblastoma. (adapted from Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Spinal Cord Hamartoma

A hamartoma that occurs in the spinal cord.


Grade 4 Other Renal or Genitourinary, CTCAE


Grade 3 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Lymphoma, AIDS-Related

An aggressive lymphoma that develops in HIV-positive patients.  There is a significant increase in the incidence of lymphomas associated with the AIDS epidemic.  These lymphomas are usually extranodal, most often express a B-cell phenotype and morphologically are classified as Burkitt, diffuse large B-cell, and Hodgkin lymphomas.  The prognosis is closely related to the severity of immunodeficiency.


Stage IV Appendix Neuroendocrine Tumor AJCC v7

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Grade 1 Other Blood and Bone Marrow, CTCAE


Rectal Ulcer, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the rectum.


Cervical Neuroendocrine Tumor

A well-differentiated neuroendocrine neoplasm that arises from the cervix. It may be classified as G1 (low grade) or G2 (intermediate grade) neuroendocrine tumor.


Gastric Antrum Carcinoma In Situ AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Primary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtype

A rare, mature T-cell lymphoma arising from the skin.


Grade 3 Non-Malignant Pericardial Effusion, CTCAE


Locally Advanced Urothelial Carcinoma

A urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Urothelial Carcinoma, High Grade

Urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


Grade 3 Edema Limbs, CTCAE

>30% inter-limb discrepancy in volume; gross deviation from normal anatomic contour; limiting self care ADL


Grade 2 Stomach Intra-Operative Injury, CTCAE


Grade 2 Small Bowel NOS Intra-Operative Injury, CTCAE


Recurrent Astrocytoma, IDH-Mutant

The reemergence of IDH-mutant astrocytoma after a period of remission.


Accidental Injuries

Unintentional trauma to the body.


Vaginal Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures).


Congenital Vena Cava Abnormality

An abnormality of the superior or inferior vena cava that is present at birth. Representative examples include persistent left superior vena cava, absence of infrarenal inferior vena cava, or absence of the entire inferior vena cava.


Grade 3 Vestibular Disorder, CTCAE

Severe symptoms; limiting self care ADL


Grade 4 Cranial Nerve III Intra-Operative Injury, CTCAE


Grade 2 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Serum CEA Level Elevated

The amount of carcinoembryonic antigen present in a serum sample is elevated.


Grade 5 Pulmonary Valve Disease, CTCAE

Death


Post-Treatment Lyme Disease Syndrome

A constellation of symptoms lasting months to years reported by some Lyme disease patients who had undergone previous antibiotic therapy.


Childhood Langerhans Cell Histiocytosis with Risk Organ Involvement

Langerhans cell histiocytosis that occurs during childhood and involves the bone marrow, spleen, liver, or lung.


Grade 1 Rectal Fistula, CTCAE

Asymptomatic


Grade 1 Body Odor, CTCAE

Mild odor; physician intervention not indicated; self care interventions


Prostate Non-Neoplastic Disorder

A non-neoplastic disorder that affects the prostate gland.  Representative examples include acute and chronic prostatitis.


Grade 5 Cranial Nerve VII Neuropathy, CTCAE


Grade 5 Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Adverse Event Associated with the Endocrine System


Grade 4 Nervous System Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Intraoperative Reproductive Tract Injury, CTCAE

Death


Grade 2 Lung Intra-Operative Injury, CTCAE


Stage IB Pancreatic Cancer AJCC v8

Stage IB includes: T2, N0, M0. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metanephric stromal tumor

A rare benign renal neoplasm composed of moderately cellular spindle cells. It occurs mostly in infancy and childhood.


Grade 5 Rectum Stricture or Stenosis, CTCAE


Extraocular Muscle Paresis, CTCAE

A disorder characterized by incomplete paralysis of an extraocular muscle.


Grade 1 Gastrointestinal Fistula, CTCAE

Asymptomatic


Device Related Infection, CTCAE

A disorder characterized by an infectious process involving the use of a medical device.


Ipsilateral Nodule

A metastatic tumor nodule located in the same side of the organ in which the primary tumor occurred.


Grade 5 Nephrotic Syndrome, CTCAE

Death


Lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 3 Hydrocephalus, CTCAE

Severe symptoms or neurological deficit; intervention indicated


Grade 2 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Joint Infection, CTCAE

A disorder characterized by an infectious process involving a joint.


Blood Cardiac Troponin I Increased

A laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen.


Grade 3 Trachea Intra-Operative Injury, CTCAE


Grade 2 Bronchus Obstruction and Stenosis, CTCAE


Miscellaneous Neoplasm

A benign or malignant neoplasm which is not further characterized.


Prolapse of Intestinal Stoma, CTCAE

A finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface.


Grade 2 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


Esophageal Adenocarcinoma by AJCC v8 Pathologic Stage

A term that refers to the pathologic staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Urinary Frequency, CTCAE

A disorder characterized by urination at short intervals.


Grade 3 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

Severe symptoms; limiting self care ADL; hospitalization


Scrotal hernia

The protrusion of abdominal cavity contents into the scrotal sac.


Integumentary System Signs and Symptoms

Patient complaints (symptoms), physical and/or laboratory findings related to the skin or integument.


Stage I Cervical Cancer AJCC v6 and v7

Stage I includes: I (T1, N0, M0); IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0); IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1: Cervical carcinoma confined to uterus (extension to corpus should be disregarded). T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread.  T1a2: Measured stromal invasion more than 3.0mm and not more than 5.0 mm with a horizontal spread 7.0mm or less. T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 1 Cranial Nerve XI Intra-Operative Injury, CTCAE


COVID-19-Associated Encephalitis

Encephalitis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Childhood Neurofibroma

A neurofibroma that occurs during childhood.


Recurrent Malignant Nongerminomatous Germ Cell Tumor

The reemergence of a malignant nongerminomatous germ cell tumor after a period of remission.


Grade 3 Rectal Pain, CTCAE

Severe pain; limiting self care ADL


Refractory Malignant Male Reproductive System Neoplasm

Malignant male reproductive system neoplasm that is resistant to treatment.


Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Extraocular Muscle Paresis, CTCAE

Bilateral paresis requiring head turning to see beyond central 60 degrees or double vision in central gaze


Grade 1 Vasculitis, CTCAE

Asymptomatic, intervention not indicated


Enterocolitis, CTCAE

A disorder characterized by inflammation of the small and large intestines.


Grade 2 Neonatal Pulmonary Hemorrhage, AE

An adverse event in a newborn characterized by hemorrhagic secretion in an endotracheal (ET) tube; without relevant increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation; requiring minor changes in care (e.g. increase in positive end-expiration pressure (PEEP)).


Ampulla of Vater Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The mitotic count is 2-20 per 10 HPF.


Advanced Lymphoma

Lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 5 Non-Infectious Wound Complication, CTCAE


Stage IIC Appendix Carcinoma AJCC v7

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades other organs or structures.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 4 Otitis Media, CTCAE

Life-threatening consequences; urgent intervention indicated


Chest Pain Along Left Anterior Axillary Line

The location of the chest pain is along the anterior axillary line on the left side.


Cervical Cancer by AJCC v9 Stage

A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 9th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to sarcomas, lymphomas, and melanomas. Sarcomas are staged according to the corpus uteri classification for sarcomas. Lymphomas are staged according to Hodgkin and non-Hodgkin lymphoma classification. Melanomas are not staged. (from AJCC 9th Ed.)


Grade 2 Hiccups, CTCAE

Moderate symptoms; medical intervention indicated; limiting instrumental ADL


Blood and Lymphatic System Disorders, CTCAE


Childhood Schwannoma

A schwannoma that occurs during childhood.


Recurring Adverse Event

An adverse event that occurs and resolves during a cycle or course of medical intervention and then reoccurs in a later cycle or course.


Digestive System Neuroendocrine Tumor by AJCC v7 Stage

A term that refers to the staging of a digestive system neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


Grade 1 Eyelid Function Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Methemoglobinemia, CTCAE

A disorder characterized by laboratory test results that indicate increased methemoglobin in the blood.


Childhood Hodgkin Lymphoma by Toronto Guidelines v2 Stage

A term that refers to the staging of childhood Hodgkin lymphoma according to the Toronto childhood cancer staging guidelines v2. Staging is the same for both tiers (tier 1 and 2).


Grade 2 Nervous System Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 2 Spinal Cord Intra-Operative Injury, CTCAE


Stage IIA1 Cervical Cancer AJCC v8

Stage IIA1 includes: T2a1, Any N, M0. T2a1: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Refractory Neuroendocrine Carcinoma

Neuroendocrine carcinoma that does not respond to treatment.


Cutaneous Melanoma by AJCC v8 Stage

A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system. This staging system does not apply to melanoma of the conjunctiva, melanoma of the uvea, mucosal melanoma arising in the head and neck, and mucosal melanoma of the urethra, vagina, rectum, and anus. (from AJCC 8th Ed.)


Pelvis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Grade 2 Small Intestinal Perforation, CTCAE

Invasive intervention not indicated


Dermal nerve sheath myxoma

A usually painless, slow growing benign tumor that most often arises from the extremities. It is characterized by the presence of abundant myxoid matrix and small epithelioid neoplastic Schwann cells.


Congenital Amegakaryocytosis

A rare disorder of infancy characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Grade 2 Thyroid Intra-Operative Injury, CTCAE


Grade 2 Stoma GI Stricture or Stenosis, CTCAE


Grade 1 Duodenal Fistula, CTCAE

Asymptomatic


Grade 1 Cranial Nerve VIII Neuropathy, CTCAE


Ventricular Fibrillation, CTCAE 5.0

A disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles.


Grade 5 Psychosis Including Hallucinations and Delusions, CTCAE


Cannabis dependence, episodic

Physical and psychological dependence on the drug cannabis, which is associated with a pattern of episodic use.


Closed dislocation of hip

A closed dislocation of the hip.


Grade 5 Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Joint Intra-Operative Injury, CTCAE


Grade 4 Lymph Gland Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Upper Extremity Vein Intra-Operative Injury, CTCAE


Metastatic Pancreatic Neuroendocrine Neoplasm

A pancreatic neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


Grade 4 Hypocalcemia, CTCAE

Corrected serum calcium of <6.0 mg/dL; <1.5 mmol/L; Ionized calcium <0.8 mmol/L; life-threatening consequences


Grade 3 Cranial Nerve V Neuropathy, CTCAE


Grade 3 Dyspnea, CTCAE

Shortness of breath at rest; limiting self care ADL


Peripheral Ischemia, CTCAE

A disorder characterized by impaired circulation to an extremity.


Grade 3 Chronic Kidney Disease, CTCAE

eGFR or CrCl 29-15 ml/min/1.73 m2


Non-Neoplastic Hematologic and Lymphocytic Disorder

A disorder that arises from the bone marrow or lymphoid system and is characterized by the absence of a clonal cellular component. It rarely progresses to a malignant neoplasm.


Grade 3 Hypoparathyroidism, CTCAE

Severe symptoms; medical intervention or hospitalization indicated


Grade 5 Treatment Related Secondary Malignancy, CTCAE

Death


Stage II Urethral Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Supraventricular Arrhythmia NOS, CTCAE


Mesonephric Hyperplasia

A hyperplasia of the mesonephric cells.


Stage IB Ampulla of Vater Cancer AJCC v7

Stage IB includes: T2, N0, M0. T2: Tumor invades the duodenal wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Corrosive injury

Destruction of tissue by a chemical substance.


Grade 4 Neonatal Bradyarrhythmia, AE

A bradyarrhythmia adverse event in a newborn characterized by life-threatening consequences (e.g. shock); requiring urgent major care changes.


Grade 4 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Contact lens overwear syndrome (disorder)

Ocular pain which may be very intense, accompanied by corneal epithelium damage, conjunctival injection, lacrimation, blepharospasm, photophobia and hazy vision following corneal edema caused by overwear of contact lenses, principally the PMMA type.