neuroendocrine carcinoma of anal canal

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Grade 3 Restrictive Cardiomyopathy, CTCAE

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

Symptomatic heart failure or other cardiac symptoms, responsive to intervention; new onset of symptoms


Grade 2 Bullous Dermatitis, CTCAE

Blisters covering 10-30% BSA; painful blisters; limiting instrumental ADL


Lugano Classification Limited Stage Adult Hodgkin Lymphoma AJCC v8

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

Limited stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Burning Chest Pain

The sensation of chest pain described as an intense discomfort, similar to that experience as a result of a thermal burn, distinct from sharp, stabbing or aching, often related to nerves; sometimes used to describe gastric or esophageal pain.


Unresectable Adenoid Cystic Carcinoma

Adenoid cystic carcinoma that is not amenable to surgical resection.


Intraoperative Head and Neck Injury

Damage to head and neck during a surgical procedure.


AIDS-Related Diffuse Small Cleaved Cell Lymphoma

A non-Hodgkin lymphoma occurring in HIV-positive patients.  It is composed of small cleaved lymphocytes.


Grade 3 Hypertriglyceridemia, CTCAE

>500 mg/dL-1000 mg/dL; >5.7 mmol/L-11.4 mmol/L


Bile Duct Mucinous Cystic Neoplasm, Low Grade

A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of mild atypia.


Childhood Gliosarcoma

A gliosarcoma that occurs during childhood.


Grade 1 Radiculitis, CTCAE

Mild symptoms


Grade 5 Hepatic Hemorrhage, CTCAE

Death


Undifferentiated Carcinoma of Unknown Primary

An undifferentiated carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified.


Grade 4 Wheezing, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Parapsoriasis lichenoides

A rare condition that stimulated chronic radiodermatitis.  It is considered a variant of mycosis fungoides.


acute undifferentiated leukemia in relapse

The reemergence of acute undifferentiated leukemia after a period of remission.


Sweat Gland Tubular Carcinoma

An aggressive adenocarcinoma that arises from the sweat glands. It usually presents as a firm, erythematous nodular lesion in the axilla. Morphologically, it is characterized by the presence of tubular structures and apocrine differentiation.


Grade 3 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage III Vulvar Cancer AJCC v8

Stage III includes: T1-T2, N1-N2c, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. N2a: Three or more lymph node metastases each less than 5 mm. It includes micrometastasis, N2mi. N2b: Two or more lymph node metastases equal to 5 mm. N2c: Lymph node(s) metastasis with extranodal extension. M0: No distant metastasis. (AJCC 8th Ed.)


Reaction to Medicinal Component of Device

Any local or systemic adverse reaction to the medicinal component of a combination product.


Parathyroid chief-cell hyperplasia

A hyperplasia of the chief cells of the parathyroid gland.


Grade 5 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Lower Thigh Pain

A painful sensation in the distal thigh area.


Grade 3 Esophageal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 2 Vaginal Discharge, CTCAE

Moderate to heavy vaginal discharge; use of perineal pad or tampon indicated


Balloon cell nevus

An uncommon variant of melanocytic nevus. It presents as a small pigmented skin lesion. It is characterized by the presence of large melanocytes with clear, foamy or finely vacuolated cytoplasm. It may recur if it is not completely excised.


Endocrine Therapy Toxicity

Indicates that a toxicity adverse effect has been experienced during endocrine drug treatment.


Microcyst

A tiny cyst that is usually identified by microscopic examination in a tissue specimen.


Sacral Myelocele

Herniation of spinal cord tissue and meninges through a defect in the sacral region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Grade 2 Neonatal Sinus Bradycardia, AE

An adverse event in a newborn characterized by persistent sinus bradycardia; no change in age-appropriate behavior; requiring minor care changes (e.g. concomitant medication adapted, intermittent increase of fraction of inspired oxygen (FiO2)).


Gallbladder Perforation, CTCAE 5.0

A disorder characterized by a rupture in the gallbladder wall.


Grade 4 Pancreatic Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Hepatic Infection, CTCAE

Death


Grade 3 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Anorectal Infection, CTCAE

Death


Metastatic Neoplasm to the Bladder

The spread of a malignant neoplasm to the urinary bladder wall from an adjacent or distant anatomic site.


Grade 5 Tracheal Hemorrhage, CTCAE

Death


Stage y-III Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

Incomplete excision of the tumor (gross or microscopic extension beyond the resection margins). Involved abdominal lymph nodes, including necrotic tumor or chemotherapy-induced changes. Tumor rupture before or intraoperatively. Tumor has penetrated the peritoneal surface. Tumor thrombi present at resection margins. Surgical biopsy prior to resection (does not include needle biopsy). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 3 Hypomagnesemia, CTCAE

<0.9-0.7 mg/dL; <0.4-0.3 mmol/L


Long-Term Effects Secondary to Cancer Therapy in Children


Lugano Classification Stage III Adult Lymphoma AJCC v8

Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Prolapse of Urostomy, CTCAE

A finding of displacement of the urostomy.


Acute Submassive Pulmonary Embolism

Acute pulmonary embolism with evidence of right ventricular dysfunction, but not associated with systemic hypotension.


Enterochromaffin-Like Cell Neuroendocrine Tumor G1

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) arising from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like type granules in the neoplastic cells.


Colonic Fistula, CTCAE

A disorder characterized by an abnormal communication between the large intestine and another organ or anatomic site.


Invasive Conventional Urothelial Carcinoma

Invasive urothelial carcinoma characterized by the presence of malignant cells forming trabeculae, cords, sheets, and nests. Individual malignant cells are also present.


Grade 4 Small Bowel Perforation NOS, CTCAE


Stage IVB Gallbladder Cancer AJCC v7

Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1).  N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis. (from AJCC 7th Ed.)


Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Malignant Neoplasm in the Female Reproductive System

The spread of a malignant neoplasm to the female reproductive system from an adjacent or distant anatomic site.


IgM Monoclonal Gammopathy of Undetermined Significance, Not Otherwise Specified

A subtype of IgM monoclonal gammopathy of undetermined significance that includes cases associated with MYD88 mutation and cases associated with the presence of monoclonal B-lymphocytes without the presence of abnormal lymphoplasmacytic aggregates that are diagnostic of lymphoplasmacytic lymphoma or other small B-lymphocytic neoplasms.


Grade 5 Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


Folliculitis, CTCAE

A disorder characterized by inflammation or infection of the hair follicles.


Chronic Total Occlusion Vessel

A longstanding, complete blockage of a vessel. (ACC)


Grade 2 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Hematoma of rectus sheath

A collection of blood in the rectus sheath due to disruption of the superior or inferior epigastric arteries, which may present following direct trauma to the rectus abdominis muscle or anticoagulation therapy.


Malignant Germinative Follicular Epithelium Neoplasm

A malignant neoplasm that arises from germinative follicular epithelial cells.


Ampulla of Vater Cancer by AJCC v7 Stage

A term that refers to the staging of ampulla of Vater cancer according to the American Joint Committee on Cancer, 7th edition.


Recurrent Childhood Central Nervous System Neoplasm

The reemergence of central nervous system neoplasm in childhood after a period of remission.


Grade 4 Conduction Disorder, CTCAE

Life-threatening consequences


Grade 2 Upper Extremity Artery Intra-Operative Injury, CTCAE


Grade 4 Anal Necrosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 1 Cranial Nerve VII Neuropathy, CTCAE


Hypothyroidism, CTCAE

A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland.


Grade 3 Stroke, CTCAE

Severe neurologic deficit; limiting self care ADL; hospitalization


Grade 2 Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE


COVID-19-Associated Stroke

Cerebrovascular accident caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Stage 0 Uterine Corpus Cancer

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas.  FIGO no longer includes Stage 0 (Tis). (AJCC 7th ed.)


Grade 4 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pulmonary Edema, CTCAE

Severe dyspnea or dyspnea at rest; oxygen indicated; limiting self care ADL


Metastatic Digestive System Neuroendocrine Tumor G2

Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to another anatomic site.


Grade 4 Laryngeal Obstruction, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Hirsutism, CTCAE

In women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair


Grade 3 Dental and Teeth and Peridontal Pain, CTCAE


Stage IVB Cervical Cancer FIGO 2018

The cervical carcinoma has spread to distant organs. (FIGO 2018)


Grade 1 Brain Intra-Operative Injury, CTCAE


Cervical Papillary Squamous Cell Carcinoma

A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures covered with epithelial cells which show features of cervical intraepithelial neoplasia. The malignant cellular component below the papillary structures is a squamous cell carcinoma.


Intraoperative Hemorrhage

Uncontrolled bleeding during a surgical procedure.


Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during childhood.


Grade 4 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Refractory Primary Amyloidosis

Primary amyloidosis that does not respond to treatment.


Conjunctiva Intra-Operative Injury, CTCAE


Grade 5 Other Dermatology or Skin, CTCAE


Plasma Kallikrein Deficiency

A coagulation disorder characterized by the partial or complete absence of plasma-type kallikrein activity in the blood.


Grade 2 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Nipple Deformity, CTCAE

A disorder characterized by a malformation of the nipple.


Lactation Disorder, CTCAE

A disorder characterized by disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males.


Grade 5 Ventricular Fibrillation, CTCAE

Death


Grade 2 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Childhood Refractory Malignant Solid Neoplasm

A childhood malignant solid neoplasm that does not respond to treatment.


Factor VII Inactivation

Presence of inactivating antibodies to factor VII in the blood.


Intraoperative Urinary System Injury

Damage to any part of the urinary system during a surgical procedure.


Blast Injuries

The result of physical trauma sustained in an explosion.


Grade 3 Conjunctivitis, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Grade 2 Urethral Infection, CTCAE

Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Discoid Rash

A disc-shaped patch(es) of skin inflammation that is red, raised, and scaly; it typically develops on the face, scalp, and neck, and often leaves scars and dyspigmentation as a result of postinflammatory hyperpigmentation.


Grade 4 Perforation Bile Duct, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Facial Muscle Weakness, CTCAE

Moderate symptoms; limiting instrumental ADL


Adult Hodgkin Lymphoma

Hodgkin lymphoma occurring in adults.


Signet Ring Cell/Histiocytoid Carcinoma

A rare aggressive adnexal carcinoma preferentially affecting the eyelid and histopathologically resembling a metastatic lobular carcinoma of the breast and/or some adenocarcinomas arising in the gastrointestinal tract. (WHO 2018)


benign mature teratoma of pancreas

A mature teratoma that arises from the pancreas.


Recurrent Low Grade Adult Non-Hodgkin's Lymphoma


Early Prosthetic Valve Endocarditis

Prosthetic valve endocarditis that occurs days to weeks after surgery.


Advanced Pancreatic Carcinoma

Pancreatic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Meningohydroencephalocele

A congenital neural tube closure defect resulting in protrusion of the brain, the meninges, and the ventricular system through an opening in the skull, usually involving the squamous part of the occipital bone..


Skin squamous cell carcinoma metastatic

Squamous cell carcinoma of the skin which has spread to other anatomic sites.


Confusion, CTCAE 5.0

A disorder characterized by a lack of clear and orderly thought and behavior.


Grade 2 Cough, CTCAE

Moderate symptoms, medical intervention indicated; limiting instrumental ADL


Grade 4 Cerebral Artery Intra-Operative Injury, CTCAE


Refractory Cervical Adenocarcinoma

Cervical adenocarcinoma that is resistant to treatment.


Grade 1 Cerebrospinal Fluid Leakage, CTCAE

Post-craniotomy: asymptomatic; Post-lumbar puncture: transient headache; postural care indicated


Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Chest Pain Along Midclavicular Line

The location of the chest pain is along an imaginary vertical line on the chest originating from the midpoint of a clavicle.


High Grade Osteosarcoma

An aggressive osteosarcoma with high-grade morphological features. This category includes high-grade surface osteosarcoma and conventional osteosarcoma.


Grade 2 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Poorly Differentiated Prostate Adenocarcinoma

An invasive prostate adenocarcinoma characterized by the presence of poorly differentiated malignant cells.


Grade 3 Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Invasive Nested Urothelial Carcinoma

Invasive urothelial carcinoma characterized by a nested growth pattern.


Grade 3 Bronchus Obstruction and Stenosis, CTCAE


Sickle cell-thalassemia disease

Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene.


Unfavorable Hodgkin Lymphoma

A Hodgkin lymphoma with unfavorable prognosis.


Primary Parathyroid Gland Hyperplasia

Parathyroid gland hyperplasia that occurs in the absence of physiological stimuli.


Stage IVB Osteosarcoma AJCC v7

Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 2 Muscle Intra-Operative Injury, CTCAE


Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Prostatic Hemorrhage, CTCAE

Death


Lower Ribs Pain

A sensation of discomfort emanating from the inferiormost (verterbrochondral or vertebral) ribs.


Hereditary Angioedema Types I and II

Autosomal dominant inherited disorders characterized by abnormalities of C1 inhibitor. Patients present with swelling of the skin, subcutaneous tissues, and mucosa sites. In type I hereditary angioedema, the plasma levels of C1 inhibitor are decreased. In type II hereditary angioedema, the C1 inhibitor is dysfunctional and its plasma levels may be normal or elevated.


Grade 2 Portal Hypertension, CTCAE

Decreased portal vein flow


Grade 4 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Uterine Corpus Cancer by AJCC v7 Stage

A term that refers to the staging of uterine corpus cancer (carcinoma or carcinosarcoma) according to the American Joint Committee on Cancer, 7th edition.


Grade 1 Penile Infection, CTCAE

Localized, local intervention indicated


Injury To Carotid Artery, CTCAE

A finding of damage to the carotid artery.


Recurrent Malignant Bone Neoplasm

Reemergence of a malignant bone neoplasm after a period of remission.


Gallbladder Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma

A mucinous cystic neoplasm that arises from the gallbladder and it is associated with an invasive carcinomatous component.


Sporadic Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is not caused by inherited genetic mutations.


Carcinoid tumor of the liver

An extremely rare, well differentiated neuroendocrine neoplasm arising from the liver. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation.


Grade 2 Glucose Intolerance, CTCAE

Symptomatic; dietary modification or oral agent indicated


Voice Alteration

Change in the sound and/or speed of the voice. Causes include laryngeal polyp, laryngitis, laryngeal carcinoma, throat carcinoma, Parkinson's disease, multiple sclerosis, stroke, hypothyroidism, oral surgery, tracheostomy, tracheal injury, and laryngeal injury.


Grade 4 Anal Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Mediastinal Infection, CTCAE

A disorder characterized by an infectious process involving the mediastinum.


Grade 3 Sinusitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 1 Malaise, CTCAE

Uneasiness or lack of well being


TdT Positive Acute Lymphoblastic Leukemia


Anoxia

Absence or reduction of oxygen in body tissue.


Adult Gliosarcoma

A gliosarcoma occurring in adults.


Grade 1 Pancreas Intra-Operative Injury, CTCAE


Stage II Ureter Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Reactogenicity

An expected set of reactions that may occur soon after injection of a vaccine. These expected adverse reactions are a physical manifestation of the inflammatory response to the vaccine.


Mosquito-borne hemorrhagic fever

A group of viral illnesses that are vectored by mosquitoes, and that are characterized by increased susceptibility to bleeding diatheses.


Grade 2 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Intraoperative Breast Injury, CTCAE

Primary repair of injured organ/structure indicated


congenital renal arteriovenous malformation

A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the kidney.


Grade 2 Cerebrospinal Fluid Leakage, CTCAE

Post-craniotomy: moderate symptoms; medical intervention indicated; Post-lumbar puncture: persistent moderate symptoms; blood patch indicated


Grade 5 Neonatal Edema, AE

An edema adverse event in a newborn which results in death.


Craniotubular Hyperostosis

A group of sclerosing bone dysplasias characterized by pronounced sclerosis of the cranial vault and the long bones, resulting in increased cortical bone density. Most cases are caused by mutation(s) in the SOST or LRP5 genes, encoding sclerostin and low-density lipoprotein receptor-related protein 5, respectively. Other genes have been implicated, and some cases have been described, but do not yet have identified genetic mutations.


Hepatic Artery Intra-Operative Injury, CTCAE


Grade 5 Papulopustular Rash, CTCAE

Death


Middle Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


Stage IB Gestational Trophoblastic Tumor AJCC v7

Stage IB includes: T1, M0, Risk factors: high risk.  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


Premature Ventricular Contraction, CTCAE


Grade 1 Vaginal Fistula, CTCAE

Asymptomatic


Major Visceral Artery Intra-Operative Injury, CTCAE


Disseminated carcinoma

Carcinoma that is spread throughout the body.


Insomnia due to organic factors

Insomnia as a result of a physiological cause.


Grade 3 Urinary Frequency or Urgency, CTCAE


Congenital kyphosis

An abnormally increased curvature of the thoracic portion of the spine that is present at the time of birth.


Human Papillomavirus-Related Malignant Neoplasm in AIDS Patient

A malignant neoplasm caused by human papillomavirus in an a patient with a history of AIDS.


Fallopian Tube Intra-Operative Injury, CTCAE


Hypocalcemia, CTCAE

A disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the blood.


Metastatic Malignant Solid Neoplasm

A malignant solid neoplasm that has spread from its original site of growth to another anatomic site.


Grade 3 Scrotal Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 5 Pneumothorax, CTCAE

Death


Tiring Pain

A sensation of discomfort or distress that renders an individual weary and without energy.


Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Reproductive System and Breast Disorders, CTCAE


Alkylating Agent-Related Acute Myeloid Leukemia

Acute myeloid leukemia occurring as late complication of prior therapy with alkylating agents.


Invasive Bladder Large Nested Urothelial Carcinoma

A rare invasive bladder urothelial carcinoma characterized the presence of medium to large nests of malignant cells.


Complication of labor and delivery, unspecified

The occurrence of a pregnancy complication during childbirth, which includes both labor (the process of childbirth) and delivery (the birth itself).


Fibromyxolipoma

A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue and extensive myxoid change.


Salt-Wasting 21-Hydroxylase Deficiency

A classic form of congenital adrenal hyperplasia characterized by complete absence of 21-hydroxylase activity resulting in deficiency of glucocorticoids and mineralocorticoids accompanied by androgen excess causing virilization in female infants. Mineralocorticoid deficiency results in renal salt-wasting, and if untreated, hyponatremia, hyperkalemia, and shock.


Grade 2 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Appendix Mucinous Cystadenoma

A cystically dilated epithelial neoplasm arising from the appendix.  It is characterized by the presence of a cystic structure that is filled with mucus.


Hodgkin's disease, nodular sclerosis of lymph nodes of multiple sites

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 3 Gastroparesis, CTCAE

Weight loss >=20% from baseline; tube feeding or TPN indicated; elective operative intervention indicated


Metastatic Bladder Small Cell Neuroendocrine Carcinoma

Bladder small cell neuroendocrine carcinoma that has spread to another anatomic site.


Prostate Cancer by Whitmore-Jewett Stage

A term that refers to the staging of prostate carcinoma according to the Whitmore-Jewett staging system.


Grade 3 Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Injury To Inferior Vena Cava, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Chylothorax, CTCAE

A disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity.


Small Bowel Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Clinical Stage II Cutaneous Melanoma AJCC v8

Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 4 Thorax Soft Tissue Necrosis, CTCAE


Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA

Chronic eosinophilic leukemia characterized by the rearrangement of the PDGFRA gene, most often resulting in the formation of FIP1L1-PDGFRA fusion transcripts.


Suicidal Ideation, CTCAE

A disorder characterized by thoughts of taking one's own life.


Childhood Acute Lymphoblastic Leukemia by Toronto Guidelines v2

A term that refers to the staging of childhood acute lymphoblastic Leukemia according to the Toronto childhood cancer staging guidelines v2.


Grade 5 Social Circumstances - Other, Specify, CTCAE

Death


Angiosarcoma recurrent

The reemergence of angiosarcoma after a period of remission.


Glioblastoma by Gene Expression Profile

Classification of glioblastoma into molecular subtypes as defined by gene expression profiling.


Metastatic Midgut Neuroendocrine Tumor

A midgut neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Grade 1 Chylothorax, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Fluid Discharge

The pouring forth of a fluid.


Grade 3 Uterus Stricture or Stenosis, CTCAE


Stage III Anal Cancer AJCC v8

Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T4, N0, M0); IIIC: (T3, N1, M0); (T4, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. T3: Tumor larger than 5 cm. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


Photophobia, CTCAE 5.0

A disorder characterized by fear and avoidance of light.


Grade 1 Memory Impairment, CTCAE

Mild memory impairment


Grade 5 Spermatic Cord Perforation, CTCAE


Primary acquired melanosis

A spectrum of neoplastic changes that occur in the conjunctiva and range from melanocytic hyperplasia through degrees of atypia to melanoma in situ. The lesions are generally unilateral but often multifocal and appear as flat, irregular brown discolorations of the conjunctiva. They usually affect middle-aged and elderly Caucasians. (WHO 2018)


Meningeal Gliomatosis

Diffuse or multifocal infiltration of the meninges by malignant glioma.


Mediastinal Hemorrhage

Bleeding originating from the mediastinum.


Upper Airway Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Grade 2 Middle Ear Inflammation, CTCAE

Serous otitis, medical intervention indicated


Grade 5 Hypoxia, CTCAE

Death


Grade 2 Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Gallbladder Goblet Cell Carcinoid

An invasive mixed adenoneuroendocrine carcinoma of the gallbladder characterized by the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.


Post-Study Adverse Event

An adverse event that occurred after the patient had completed a clinical study (including any protocol-required post-treatment follow-up).


High Grade Prostatic Intraepithelial Neoplasia, Small Cell Neuroendocrine Variant

High grade prostatic intraepithelial neoplasia characterized by the presence of small neuroendocrine cells in the affected glands.


Grade 3 Uterine Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Locally Advanced Ampulla of Vater Carcinoma

Carcinoma that arises from the ampulla of Vater and has spread to nearby tissues or lymph nodes.


Grade 4 Infantile Apnea, AE

An apneic adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; (semi-)urgent intubation required.


Intraoperative Respiratory Injury

Damage to the respiratory system during a surgical procedure.


Pleural Infection, CTCAE

A disorder characterized by an infectious process involving the pleura.


Grade 2 CNS Necrosis and Cystic Progression, CTCAE


Grade 5 Ileal Perforation, CTCAE

Death


Grade 3 Breast Pain, CTCAE

Severe pain; limiting self care ADL


Monomorphic Post-Transplant Lymphoproliferative Disorder

A clonal lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed lymphocytes or plasma cells.  It includes two variants: monomorphic B-cell and monomorphic T/NK cell post-transplant lymphoproliferative disorders.


Grade 4 Respiratory Failure, CTCAE

Life-threatening consequences; urgent intervention, intubation, or ventilatory support indicated


Grade 4 Oral Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Laryngopharyngeal Dysesthesia, CTCAE

Mild symptoms; no anxiety; intervention not indicated


Grade 4 Lower Extremity Soft Tissue Necrosis, CTCAE


Grade 1 Spasticity, CTCAE

Mild or slight increase in muscle tone


Zoonotic Spillover

Transmission of an infectious disease from a reservoir vertebrate population with a high pathogen prevalence coming into contact with a naive human population.


Grade 5 Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Lower Extremity Vein Intra-Operative Injury, CTCAE


Pathologic Stage IV Retinoblastoma AJCC v8

Stage IV includes: Any pT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


EBV-Associated Smooth Muscle Tumor

A rare smooth muscle neoplasm of uncertain biological potential. It is associated with Epstein-Barr virus infection and seen in patients with immunodeficiency, including primary immunodeficiency, HIV/AIDS infection, and post-transplant immunosuppression.


Grade 5 Soft Tissue Infection, CTCAE

Death


Thoracic Duct Intra-Operative Injury, CTCAE


Grade 3 Bronchial Stricture, CTCAE

Shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement)


Locally Advanced Carcinoma

A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Chest Pain Along Left Middle Sternal Border

The location of the chest pain is along the left middle border of the sternum.


Grade 1 Pharynx Intra-Operative Injury, CTCAE


Grade 5 Oral Cavity Fistula, CTCAE

Death


Myocardial degeneration

Degeneration of myocardial tissue.


Grade 2 Cervical Spine Range of Motion, CTCAE


Astler-Coller C2 Colon Carcinoma

Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


Postneoadjuvant Therapy Stage IVB Esophageal Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Gastrinoma, malignant

A gastrin-producing neuroendocrine tumor.  It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome.  It displays vascular invasion and metastasizes to other anatomic sites.


Congenital Defects of Phagocyte Number, Function, or Both

A group of diseases or disorders caused by genetic defects within the immune system and comprising: Congenital neutropenia; Defects of motility; Defects of respiratory burst; and other nonlymphoid defects.


Neonatal Convulsion, AE

An adverse event in a newborn characterized by sudden, involuntary, rapid rhythmic or stereotyped skeletal muscular contraction.


Grade 1 Ovarian Rupture, CTCAE

Asymptomatic clinical or diagnostic observations only; intervention not indicated


Megakaryocytic Neoplasm

A neoplasm affecting cells of the megakaryocytic lineage.


Grade 4 Neonatal Convulsion, AE

An adverse event in a newborn characterized by suspected seizures with life-threatening consequences (e.g. need for ventilation); suspected status epilepticus (greater than 30 minutes of convulsions within any 60 minute period) despite multiple anti-seizure drugs.


Grade 1 Esophageal Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Pyramidal Tract Syndrome, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 1 Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Grade 2 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Blood Lactate Dehydrogenase Increased, CTCAE

>ULN


Resin Fume Exposure

Environmental, occupational, or consumer-based exposure epoxy compounds and other volatile chemicals associated with production and handling of resins (liquid plastics).


Grade 3 Gastric Necrosis, CTCAE

Inability to aliment adequately by GI tract; invasive intervention indicated


Grade 2 Tongue Intra-Operative Injury, CTCAE


Acidosis, CTCAE

A disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues.


Chronic Cutaneous Graft Versus Host Disease

Chronic graft versus host disease (GvHD) occurring in the skin.


Injury of bronchus

Trauma to the lung bronchi.


Malignant melanoma in junctional nevus

A melanoma arising from a melanocytic nevus which involves the dermal-epidermal junction of the skin.


Childhood Malignant Bone Neoplasm by Toronto Guidelines v2 Stage

A term that refers to the staging of childhood malignant bone neoplasm according to the Toronto childhood cancer staging guidelines v2. Staging is the same for both tiers (tier 1 and 2).


Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


Grade 5 Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE


A rare mucinous cystadenocarcinoma that arises from the paratesticular structures.


Grade 5 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Serum Hypertriglyceridemia, CTCAE


Recurrent Cancer of Gallbladder

The reemergence of gallbladder carcinoma after a period of remission.


Grade 5 Mediastinal Infection, CTCAE

Death


Grade 1 Outer Ear Pinna Intra-Operative Injury, CTCAE


INR Increased, CTCAE

A finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood.


Orbivirus infection

An infection that is caused by Orbivirus.


Phlebitis, CTCAE

A disorder characterized by inflammation of the wall of a vein.


Grade 1 Pancreatic Endocrine Glucose Intolerance, CTCAE


Unclassified Hepatocellular Adenoma

A hepatocellular adenoma without distinguished morphologic characteristics or known molecular abnormalities.


Grade 4 Eye Disorders - Other, Specify, CTCAE

Sight-threatening consequences; urgent intervention indicated; best corrected visual acuity of 20/200 or worse in the affected eye


Grade 1 Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


Grade 2 Cranial Nerve II Intra-Operative Injury, CTCAE


Grade 5 Jejunal Fistula, CTCAE

Death


Gastric Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the stomach.


Grade 4 Gastric Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Congenital arteriovenous malformation of gastrointestinal tract

A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the gastrointestinal tract.


Serum Amylase Increased, CTCAE

A finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen.


Grade 2 Fetal Growth Retardation, CTCAE

<10% percentile of weight for gestational age


Grade 2 Upper Gastrointestinal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 2 Phantom Pain, CTCAE

Moderate pain; limiting instrumental ADL


Increased Fibroblast Growth Factor Pathway Activation

A finding indicating increases in fibroblast growth factor (FGF) activity, activation of FGF-dependent pathways and proliferation of cells in a cellular sample.


Adverse event following immunization

Any unfavorable or unintended symptom, sign, or disease including an abnormal laboratory finding) temporally associated with the previous administration of vaccine(s) that may or may not be considered related to the vaccine administration. Such events can be intervention related, dose related, route related, patient related, or caused by an interaction with other product(s) or procedure(s).


Grade 3 Non-Malignant Pleural Effusion, CTCAE


Grade 1 Hoarseness, CTCAE

Mild or intermittent voice change; fully understandable; self-resolves


Tracheostomy Site Bleeding, CTCAE

A disorder characterized by bleeding from the tracheostomy site.


Contact dermatitis due to acid

Contact dermatitis caused by exposure to acids.


Congenital His bundle tachycardia

A congenital disorder characterized by an electrocardiographic finding of tachycardia that affects neonates and infants. It results from an increased automaticity in the atrioventricular node and His bundle.


Extracranial Solid Neoplasm

A solid neoplasm involving any anatomic site other than the brain.


Grade 4 Heart Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Tumor Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Childhood Ganglioneuroma

A ganglioneuroma that occurs during childhood.


High Metal Ion Levels

High blood or serum levels of ions which are attributed to one or more medical devices used, such as but not limited to Co, Cr, Ti, Ni, Mo.


Pancreatic Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures).


Adenocarcinoma endometrial recurrent

The reemergence of endometrioid adenocarcinoma after a period of remission.


Grade 2 Intraoperative Head and Neck Injury, CTCAE

Partial resection of injured organ/structure indicated


A myelodysplastic/myeloproliferative neoplasm arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders.


Adult Favorable Prognosis Hodgkin Lymphoma

A Hodgkin lymphoma with favorable prognosis that occurs during adulthood.


Grade 5 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Unresectable Mucosal Melanoma

Mucosal melanoma that is not amenable to surgical resection.


Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Shingles, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated; limiting self-care ADL


Grade 2 Fever Without Neutropenia, CTCAE


Childhood Malignant Bone Neoplasm

A malignant neoplasm that affects the bone or articular cartilage and occurs during childhood.


Metastatic malignant neoplasm to soft tissues

A malignant neoplasm that has spread to the soft tissues from another anatomic site.


Grade 1 Colonic Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Cranial Nerve III Neuropathy, CTCAE


Grade 1 Gastrointestinal Leak NOS, CTCAE


Grade 5 Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Uterine Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


A2/3 Hydronephrosis

Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of greater than or equal to 7mm at less than 28 weeks, 2) greater than or equal to10 mm at greater than or equal to 28 weeks, or 3) any one of the following findings: a)dilation of peripheral calyces, b) abnormal parenchymal thickness or appearance, c) visibly dilated ureter, d) an abnormal bladder, or e) the presence of oligohydramnios suspected to be related to the urinary tract. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Laryngospasm, CTCAE

A disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords.


Grade 4 Fallopian Tube Hemorrhage, CTCAE


Grade 4 Otitis Externa, CTCAE

Life-threatening consequences; urgent intervention indicated


Carcinoma Unspecified Site

Carcinoma in which the site of involvement is not specified.


Locally Advanced Gallbladder Carcinoma

Gallbladder carcinoma that has spread to nearby tissues or lymph nodes.


Grade 4 Flashing Lights and Floaters in Vision, CTCAE


Grade 2 Phlebitis Infective, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage I Adult Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Grade 3 Brain Intra-Operative Injury, CTCAE


Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage II Esophageal Cancer AJCC v7

Stage II includes: For squamous cell carcinoma: IIA (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X); IIB (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIA (T2, N0, M0, G3); IIB (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Acute Myeloid Leukemia with t(17;17)(q21;q21)

Acute myeloid leukemia with variant RARA rearrangement and expression of STAT5B-RARA fusion protein.


Grade 2 Ventricular Arrhythmia, CTCAE

Non-urgent medical intervention indicated


Posterior Subcapsular Cataract Grade 2

A stage of posterior subcapsular cataract characterized by 30% of the posterior capsule obscured by opacity. (Modified LOCS II)


Hypophysitis, CTCAE

A disorder characterized by inflammation and cellular infiltration of the pituitary gland.


Grade 5 Hemorrhoidal Hemorrhage, CTCAE

Death


Grade 3 Investigations - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Recurrent T-Cell and NK-Cell Neoplasm

The reemergence of T-cell and NK-cell neoplasm after a period of remission.


Splenic Infection, CTCAE

A disorder characterized by an infectious process involving the spleen.


ASS1 Gene Deficiency

A genetic finding indicating that low expression of the ASS1 gene has been detected in a sample.


Blood and Lymphatic System Disorders - Other, Specify, CTCAE


Grade 3 Intraoperative Hemorrhage, CTCAE

Postoperative invasive intervention indicated; hospitalization


Cannabis dependence, continuous

Physical and psychological dependence on the drug cannabis, which is associated with a pattern of continuous use.


Creatinine Increased, CTCAE

A finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen.


Grade 2 Pulmonary Fibrosis, CTCAE

Evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25-50% associated with hypoxia


Grade 4 Myasthenia Gravis, CTCAE

Life-threatening consequences; urgent intervention indicated


Other Sexual Reproductive Function, CTCAE


Locally Advanced Gastric Adenocarcinoma

A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 4 Spine Kyphosis or Lordosis, CTCAE


Grade 2 Peritoneal Cavity Intra-Operative Injury, CTCAE


Anal Canal Neuroendocrine Tumor G1

A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Grade 5 Intraoperative Urinary Injury, CTCAE

Death


Bile Duct Biliary Intraepithelial Neoplasia

A neoplastic, non-invasive lesion that affects the intrahepatic or extrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Grade 3 Gastrointestinal Pain, CTCAE

Severe pain; limiting self care ADL


Locally Advanced Sarcoma

Sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 4 Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Hypohidrosis, CTCAE

Death


Childhood EBV-Associated Smooth Muscle Tumor

An EBV-associated smooth muscle tumor that occurs during childhood.


Childhood Pilomatricoma

A pilomatricoma that occurs during childhood.


Locally Advanced Unresectable Bone Sarcoma

A bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Borderline Fallopian Tube Neoplasm

A rare epithelial tumor arising from the fallopian tube without definitive morphologic characteristics of malignancy.  This category includes borderline mucinous and serous neoplasms and borderline endometrioid tumor.


Grade 2 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Recurrent Endometrial Serous Adenocarcinoma

The reemergence of endometrial serous adenocarcinoma after a period of remission.


Platinum-Refractory Fallopian Tube Carcinoma

Fallopian tube carcinoma that progresses during platinum therapy or within one month of completing the last platinum therapy.


Haptoglobin Decreased, CTCAE

A finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen.


Mild Adverse Event

An experience that is usually transient, and requires no special treatment or intervention. The event does not generally interfere with usual daily activities. Includes transient laboratory test alterations.


Stage IV Skin Cancer

Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T Any, N3, M0); (T4, N Any, M0); (T Any, N Any, M1).  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T4: Tumor with invasion of skeleton or perineural invasion of skull base.  N0: No regional lymph node metastasis.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M1: Distant metastases.  (AJCC 7th Ed.)


Sebaceoma

A benign sebaceous neoplasm arising in the deep dermis.


Breast Papillary Neoplasm

A benign or malignant papillary neoplasm that arises from the breast.  It is characterized by the presence of epithelial proliferations that are supported by fibrovascular cores.  Representative examples are intraductal papilloma and papillary carcinoma.


Grade 2 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Grade 2 Artery NOS Intra-Operative Injury, CTCAE


Castleman Disease, Hyaline-Vascular Type

The commonest type of Castleman disease. It is seen most commonly in the mediastinum. Histologically this is characterized by hyalinized germinal centers surrounded by small lymphocytes in a concentric fashion, giving an onion skin appearance.


Invasive Bladder Giant Cell Urothelial Carcinoma

An invasive urothelial carcinoma of the bladder with giant cells.


Grade 1 Hypothyroidism, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Spinal Cord Compression, CTCAE

Severe symptoms; limiting self care ADL


Grade 1 Urinary Tract Obstruction, CTCAE


Childhood Classic Hodgkin Lymphoma

Classic Hodgkin lymphoma that occurs during childhood.


Grade 2 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Pelvic hemorrhage

Bleeding within the pelvic cavity.


Unresectable Digestive System Neuroendocrine Neoplasm

A digestive system neuroendocrine neoplasm that is not amenable to surgical resection.


Grade 3 Leukoencephalopathy, CTCAE

Severe symptoms; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly


Enteroglucagonoma

An endocrine neoplasm producing glucagon.


Grade 2 Injury To Superior Vena Cava, CTCAE

Symptomatic; repair or revision not indicated


Grade 2 Ileal Ulcer, CTCAE

Symptomatic; altered GI function


Grade 3 Myelitis, CTCAE

Severe weakness or sensory loss; limiting self care ADL


Grade 1 Restlessness, CTCAE

Mild symptoms; intervention not indicated


Grade 1 Laryngeal Inflammation, CTCAE

Mild sore throat; raspy voice


Recurrent Nevus

A nevus that recurs after incomplete surgical removal, biopsy, or trauma. (WHO 2018)


Venomous Animal Contact

Contact with a venomous animal.


Locally Advanced Squamous Cell Carcinoma

A squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Fallopian Tube Perforation, CTCAE

Invasive intervention indicated


Grade 4 Alkalosis, CTCAE

Life-threatening consequences


Grade 4 Neck NOS Intra-Operative Injury, CTCAE


Major Congenital Anomaly

A major congenital anomaly is a structural or functional defect with the following three characteristics: 1) Of prenatal origin; 2) Present at the time of live birth or fetal demise, or in utero; 3) Affecting (or has the propensity to affect) the health, survival, or physical or cognitive functioning of the individual.


Carcinoma of unknown primary

A carcinoma which has metastasized from an unknown primary anatomic site.


Grade 2 Anal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Acute Kidney Injury, CTCAE

A disorder characterized by the acute loss of renal function (within 2 weeks) and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction).


Hematopoietic and Lymphoid Neoplasm (Antiquated)


Grade 3 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Blood Bicarbonate Decreased, CTCAE

A finding based on laboratory test results that indicate a decrease in levels of bicarbonate in a venous blood specimen.


Grade 1 Colonic Fistula, CTCAE

Asymptomatic


Adverse Event with No Consequence or Impact

No apparent harm occurred in relation to the adverse event.


Invasive Lymphoepithelioma-Like Urothelial Carcinoma

Invasive urothelial carcinoma with lymphoepithelioma-like features.


Clinical Chorioamnionitis

Inflammation of the fetal sac membranes, characterized by otherwise unexplained fever (at or above 38 degree C (100.4F)) with one or more of the following: uterine tenderness and/or irritability, leukocytosis, fetal tachycardia, maternal tachycardia, or malodorous vaginal discharge.


Ventral hernia without mention of obstruction or gangrene

The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, without mention of obstruction or necrosis of the herniated contents.


Lumbar meningomyelocele

A congenital abnormality in the lumbar region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Grade 4 Pharyngeal Hemorrhage, CTCAE

Life-threatening consequences; intubation or urgent intervention indicated


Grade 5 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Grade 3 Dysarthria, CTCAE

Severe impairment of articulation or slurred speech


Grade 4 Brachial Plexus Intra-Operative Injury, CTCAE


Adverse Event by CTCAE v4 Severity Grade


Autoimmune Atrophic Chronic Gastritis

Chronic atrophic gastritis that is caused by autoimmune destruction of parietal cells in the stomach resulting in hypochlorhydria and decreased production of intrinsic factor.


Stage I Low-CSD Melanoma AJCC v7

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 3 Papilledema, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200)


Grade 5 Intraoperative Head and Neck Injury, CTCAE

Death


Grade 4 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Central Nervous System Hemorrhage, CTCAE


Grade 4 Intraoperative Gastrointestinal Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Urinary Tract NOS Intra-Operative Injury, CTCAE


Grade 2 Hepatobiliary Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 4 Nails Intra-Operative Injury, CTCAE


Malignant Bladder Paraganglioma

An extra-adrenal sympathetic paraganglioma of the bladder that metastasizes to other anatomic sites.


Grade 2 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Gallbladder Infection, CTCAE

A disorder characterized by an infectious process involving the gallbladder.


Grade 4 Persistent Pulmonary Hypertension of the Newborn, AE

A persistent pulmonary hypertension adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; extracorporeal membrane oxygenation (ECMO) required; oxygenation index greater than 40.


Grade 4 Artery NOS Intra-Operative Injury, CTCAE


Infant Leukemia

An acute lymphoblastic or acute myeloid leukemia that occurs in infancy.


Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Complication due to Medical/Surgical Care

An untoward event that can be attributed to care received during a medical/surgical event.


Ancylostomiasis due to Ancylostoma ceylonicum (disorder)

Infection by Ancylostoma ceylanicum.


Distal Esophagus Adenocarcinoma

An adenocarcinoma arising from the lower third of the esophagus. The vast majority of esophageal adenocarcinomas involve the lower third of the esophagus.


Grade 3 Rectal Necrosis, CTCAE

Tube feeding or TPN indicated; invasive intervention indicated


Grade 2 Peripheral Sensory Neuropathy, CTCAE

Moderate symptoms; limiting instrumental ADL


Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Neonatal Intraventricular Hemorrhage, AE

An adverse event in a newborn characterized by hemorrhage occupying less than 50% of ventricular volume without ventricular dilatation greater than 4mm above the 97th percentile.


Elevated EBV DNA

A finding indicating elevated concentrations of Epstein-Barr virus DNA in a sample.


Cervical intraepithelial neoplasia grade 1

Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Diffuse KATP-Associated Hyperinsulinism

KATP-associated hyperinsulinism affecting all pancreatic beta cells.


Recurrent Acute Erythroid Leukemia

The reemergence of acute erythroid leukemia after a period of remission.


Anxiety disorder due to a general medical condition

An anxiety disorder in which the symptoms of anxiety have been determined to be the direct physiological consequence of a general medical condition.


Aspiration, CTCAE

A disorder characterized by inhalation of solids or liquids into the lungs.


Grade 2 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Stage IVB Cervical Cancer FIGO 2009

Cervical carcinoma involving distal organs outside the pelvis. (FIGO 2009)


Basal cell carcinoma - keratotic

A variant of basal cell carcinoma with the architectural features of a nodular basal cell carcinoma.  It is characterized by the formation of keratin (horn cysts) in the center of the tumor islands.  Dystrophic calcification is frequently present.


Grade 5 Pyramidal Tract Dysfunction, CTCAE


Grade 4 Bronchopleural Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Complication

Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure.


Anaplastic Diencephalic Astrocytoma

An anaplastic astrocytoma that occurs in the diencephalon.


Grade 4 Respiratory Tract Hemorrhage NOS, CTCAE


A reactive proliferation of the conjunctival squamous epithelium not associated with glandular elements.


Philadelphia Chromosome Negative BCR-ABL1 Negative Chronic Myelogenous Leukemia


Recurrent Lymphoid Leukemia

The reemergence of lymphoid leukemia after a period of remission.


Grade 2 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Lymphoproliferative Disease Associated with Primary Immune Disorder

A lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder. The primary immune disorders most frequently associated with lymphoproliferative disorders are ataxia-telangiectasia, Wiskott-Aldrich syndrome, common variable immunodeficiency, severe combined immunodeficiency, X-linked lymphoproliferative disease, Nijmegen breakage syndrome, hyper-IgM syndrome, and autoimmune lymphoproliferative syndrome. (WHO 2017)


Grade 4 Leukocytosis, CTCAE

Clinical manifestations of leucostasis; urgent intervention indicated


Grade 2 Bladder Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Radiating Chest Pain Along Right Lower Sternal Border

The location of the radiating chest pain is along the right lower sternal border.


Recurrent Histiocytic and Dendritic Cell Neoplasm

The reemergence of a histiocytic and dendritic cell neoplasm after a period of remission.


Grade 1 Pancreatic Fistula, CTCAE

Asymptomatic


Stage III Childhood Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Vascular anomaly of eyelid

Any non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels of the eyelid.


Stage III Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0). T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. T3: Tumor of any size with invasion into surrounding tissues (e.g., liver, pancreas, spleen, kidneys). N1: Regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Stage IIIA Esophageal Adenocarcinoma AJCC v7

Stage IIIA includes: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Oligospermia, CTCAE

A disorder characterized by a decrease in the number of spermatozoa in the semen.


Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Grade 3 Appendix Intra-Operative Injury, CTCAE


verrucous carcinoma of vagina

A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, acanthotic epithelium with minimal or absent atypia, and pushing borders.


Elevated LDH

An indication that the concentration of lactate dehydrogenase found in a sample is higher than previous noted or above the normal range.


Grade 1 Injection Site Reaction, CTCAE

Tenderness with or without associated symptoms (e.g., warmth, erythema, itching)


Grade 4 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Injection Site Reaction, CTCAE

Death


Grade 5 Laryngeal Stenosis, CTCAE

Death


Grade 4 Blood Bilirubin Increased, CTCAE

>10.0 x ULN if baseline was normal; >10.0 x baseline if baseline was abnormal


Grade 1 Lower Extremity Intra-Operative Injury, CTCAE


Testicular Seminoma with Syncytiotrophoblastic Cells

A testicular seminoma characterized by the presence of syncytiotrophoblastic giant cells.


Peritoneal Implant

Deposits of borderline, malignant, and rarely benign tumors, usually from the ovary, on the peritoneal surface.


Grade 1 Anorgasmia, CTCAE

Inability to achieve orgasm not adversely affecting relationship


Resectable Cutaneous Melanoma

Cutaneous melanoma that is amenable to surgical resection.


Infections and Infestations - Other, Specify, CTCAE


Sinusitis, CTCAE

A disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses.


Grade 2 Recurrent Laryngeal Nerve Palsy, CTCAE

Moderate symptoms


Grade 4 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Cranial Nerve VI Intra-Operative Injury, CTCAE


Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

An acute myeloid leukemia with recurrent genetic abnormalities occurring in adults.


High Grade Liver Dysplastic Nodule

A hepatic dysplastic nodule characterized by the presence of high grade atypical cellular changes.


Sporadic Gastric Adenocarcinoma

A primary adenocarcinoma of the stomach in a patient with no family history of gastric cancer or inherited high risk mutations.


Subacute Placental Infarction

A focus of necrotic placental parenchyma with moderate hyalinization and fibrosis with partial absence of the necrotic chorionic villi, which is frequently 3-5 days of duration.


K ATP Permanent Neonatal Diabetes

K ATP channel-associated neonatal diabetes mellitus that does not resolve spontaneously.


Grade 5 Superior Vena Cava Syndrome, CTCAE

Death


Resectable Sarcoma

Sarcoma that is amenable to surgical resection.


Periorbital Edema, CTCAE

A disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face.


Grade 3 Renal and Urinary Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Accident

An unforeseen and unplanned event or circumstance frequently causing loss or injury.


Clinical Stage I Cutaneous Melanoma AJCC v8

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 2 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Laryngeal Nerve Dysfunction, CTCAE


Grade 3 Hemolytic Uremic Syndrome, CTCAE

Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae)


Grade 2 Cranial Nerve VIII Intra-Operative Injury, CTCAE


Advanced Adnexal Carcinoma

Adnexal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Endometrial cystic hyperplasia

Benign endometrial hyperplasia characterized by the presence of cystically dilated glands.


Pulmonary Fibrosis Radiographic Changes, CTCAE


Grade 2 Pancreas Exocrine Enzyme Deficiency, CTCAE


Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Childhood Skin Neoplasm

A benign, intermediate, or malignant neoplasm that affects the skin and occurs during childhood.


Grade 1 Otitis Externa, CTCAE

Localized, local intervention indicated


Imaging Finding

The result of an evaluation technique using a visual display of structural or functional patterns of organs or tissues that is performed to determine the presence, absence, or degree of a condition.


Meniscal Cyst

A cyst located at the periphery of the meniscus.


Grade 1 Hypotension, CTCAE

Asymptomatic, intervention not indicated


Grade 3 Neuralgia and Peripheral Nerve Pain, CTCAE


Malignant Lymphoma, Histiocytic, Diffuse


Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Papillary mucinous cystadenoma

A usually benign and less often low malignant potential cystic epithelial neoplasm composed of cells which contain intracytoplasmic mucin. It is characterized by the presence of papillary structures.


Acute gonococcal infection of lower genitourinary tract

A gonococcal infection of the lower urinary tract that is rapid in onset.


Musculoskeletal Chest Pain due to Rib Injury

A condition in which there is musculoskeletal chest pain secondary to trauma to one or more ribs. (ACC/AHA)


Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Bronchial Infection, CTCAE

A disorder characterized by an infectious process involving the bronchi.


Parathyroid Clear Cell Hyperplasia

A hyperplasia of the clear cells of the parathyroid gland.


Paradental Cyst

An inflammatory collateral cyst that arises on the lower third molars. (WHO 2017)


FIGO Stage II Gestational Trophoblastic Tumor

Lesion invades outside of the uterus, but it is limited to the genital structures.


Malignant Paraganglionic Neoplasm

A paraganglioma that metastasizes to regional or distant anatomic sites.  Extraadrenal paragangliomas have a higher tendency to metastasize, as compared to pheochromocytomas.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


Grade 1 Lymphedema, CTCAE

Trace thickening or faint discoloration


Grade 4 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Grade 2 Ileus, CTCAE

Symptomatic; altered GI function; bowel rest indicated


Grade 1 Hematuria, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 5 Laryngitis, CTCAE

Death


Stage II Prostate Cancer AJCC v7

Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Stage IV Cervical Cancer FIGO 2018

The cervical carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. (A bullous edema, as such, does not permit a case to be allotted to Stage IV). (FIGO 2018)


Encephalopathy of Prematurity

A condition affecting premature infants characterized by white matter injury, which is frequently accompanied by neuronal/axonal disease, that may affect all brain parenchymal structures and is due to a combination of destructive processes as well as maturational and trophic disturbances.


Grade 2 Alcohol Intolerance, CTCAE

Present


Grade 3 Prolonged Intubation After Pulmonary Resection, CTCAE


Grade 4 Tracheitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Severe Aplastic Anemia

Life-threatening anemia associated with a high risk of infection or bleeding.


Refractory Extracranial Malignant Solid Neoplasm

An extracranial malignant solid neoplasm that is resistant to treatment.


Flat adenoma

An adenoma of the gastrointestinal tract mucosa which grossly and morphologically does not appear as an elevated or polypoid lesion.


Grade 2 Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


Aorta Artery Intra-Operative Injury, CTCAE


Pathologic Stage III Esophageal Adenocarcinoma AJCC v8

Stage III includes: IIIA: (T1, N2, M0, Any G); (T2, N1, M0, Any G); IIIB: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Adult Solid Neoplasm

A solid neoplasm (e.g., carcinoma, sarcoma) occurring in adults.


Grade 2 Conjunctiva Intra-Operative Injury, CTCAE


Grade 2 Gastrointestinal Stoma Hemorrhage, CTCAE


Grade 5 Colon Stricture or Stenosis, CTCAE


Disseminated Intravascular Coagulation, CTCAE

A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors.


Ampulla of Vater Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of an ampulla of Vater neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to well-differentiated neuroendocrine tumors of the ampulla of Vater. Carcinomas of the ampulla of Vater, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not included in this staging system. (from AJCC 8th Ed.)


Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


Aggressive digital papillary adenoma

An eccrine sweat gland adenoma with aggressive local growth. Most cases present as nodular lesions on the digits. It is characterized by the presence of tubular and ductal structures with areas of papillary projections into cystic lumina.


Sustained Atrial Tachyarrhythmia Related to COVID-19 other than Atrial Fibrillation or Atrial Flutter

A supraventricular tachycardia, including AV nodal re-entry, orthodromic re-entrant tachycardia, multifocal atrial tachycardia, other atrial tachycardia that lasts more then 30 seconds in a patient with probable or confirmed acute COVID-19.


Grade 1 Hypophosphatemia, CTCAE

Laboratory finding only and intervention not indicated


Ductal Eccrine Carcinoma with Spindle Cell Elements

A variant of ductal eccrine carcinoma with spindled cell appearance.


Pancreatic carcinoma recurrent

The reemergence of pancreatic carcinoma after a period of remission.


Seropositive rheumatoid arthritis

Rheumatoid arthritis in which a patient's serum is positive for certain disease-related antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is more specific than RF which can be found in other pathologic conditions. The production of these disease-associated antibodies may precede the development of clinical symptoms by several years. Seropositive patients have a greater likelihood of developing extra-articular complications and a more severe course of disease.


Spitzoid melanoma

A melanoma that shares histopathologic and clinical features with atypical Spitz nevus.


Grade 2 Fall, CTCAE

Symptomatic; noninvasive intervention indicated


Acquired Rickets

Rickets that is caused by vitamin D deficiency, hypocalcemia, or renal failure.


Diffuse Glioma

A glioma that has diffusely infiltrated the surrounding central nervous system tissues.


Grade 4 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Urethra Stricture or Stenosis, CTCAE


Acquired Phrenic Nerve Injury

Damage to the phrenic nerve that was not present at birth.


Grade 4 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Non-Infectious Wound Complication, CTCAE


Grade 1 Trigeminal Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Cranial Nerve VI Intra-Operative Injury, CTCAE


Vulvar Squamous Intraepithelial Lesion, HPV-Associated

An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by maturation abnormalities and nuclear hyperchromasia that are confined to the basement membrane.


Grade 1 Enterovesical Fistula, CTCAE

Asymptomatic


Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8

Stage IC includes: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Childhood Mixed Cellularity Classic Hodgkin Lymphoma

Mixed cellularity classic Hodgkin lymphoma occurring in childhood.


Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Cebocephaly

A congenital abnormality characterized by a malformation of the head. The eyes are hypoteleric and the nose may be absent or misshapen (small, flattened, single nostril) and defective.


Stage I Skin Cancer

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness, Clark level equal or greater than IV, and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


Grade 2 Presyncope, CTCAE

Present (e.g., near fainting)


Eyelid Function Disorder

A disorder characterized by impaired eyelid function.


Wrist Fracture, CTCAE

A finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken.


Stage IVB Prostate Cancer AJCC v8

Stage IVB includes: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


Grade 5 Neonatal Diarrhea, AE

A diarrhea adverse event in a newborn which results in death.


Stage IIC Testicular Cancer AJCC v8

Stage IIC includes: (Any pT/TX, N3, M0, S0); (Any pT/TX, N3, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Grade 3 Nasopharynx Intra-Operative Injury, CTCAE


More Than Two Separate Tumor Masses Present in the Same Organ

A finding indicating the presence of more than two separate tumor masses in the same organ.


Disinfectant Exposure

Environmental, occupational, or consumer-based exposure to epoxy compounds and other volatile chemicals associated with production, handling and use of disinfectants.


Grade 4 Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Oral Dysesthesia, CTCAE

Disabling pain; tube feeding or TPN indicated


Grade 4 Uterine Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Eye Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Peripheral Arterial Ischemia, CTCAE


Grade 3 Other Pulmonary and Upper Respiratory, CTCAE


Grade 2 Platelets, CTCAE

<75,000 - 50,000/mm(3); <75.0 - 50.0 x 10e9 /L


Glossopharyngeal Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the glossopharyngeal nerve (ninth cranial nerve).


Breast Columnar Cell Lesion

A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma.  These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units.  Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ.  Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known.


Lymphoma, Mixed-Cell

An antiquated term that refers to a lymphoma composed of a mixture of small and large lymphocytes.


Lugano Classification Stage III Adult Hodgkin Lymphoma AJCC v8

Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Pre-Gestational Diabetes

Diabetes diagnosed before current pregnancy. (reVITALize)


Grade 5 Other Blood and Bone Marrow, CTCAE


Type II Endometrial Adenocarcinoma

A classification of primary endometrial adenocarcinomas that refers to clear cell adenocarcinoma, serous adenocarcinoma, and serous endometrial intraepithelial carcinoma.


Adenovirus DNA Viremia

A laboratory test result indicating the presence of adenovirus DNA in the blood.


Grade 2 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Degenerated Schwannoma

A schwannoma that is characterized by degenerative changes such as hyalinization, hemorrhage, calcification and cystic change.


Retinopathy of Prematurity, AE

An adverse event characterized by a retinal condition of very immature infants that may be characterized by non-vascularized retinae that may lead to neovascularization, scarring, retinal detachment, and blindness.


Grade 5 Enterocolitis, CTCAE

Death


Grade 5 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Hypothermia, CTCAE

<=28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation)


Grade 2 Hypoxic Ischemic Encephalopathy, AE

An adverse event in a newborn characterized by mild transient clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event;  necessitating observation and additional care.


Lymph Gland Infection, CTCAE

A disorder characterized by an infectious process involving the lymph nodes.


Unresectable Midgut Neuroendocrine Tumor

A midgut neuroendocrine tumor that is not amenable to surgical resection.


Factor II Inactivation

Presence of inactivating antibodies to prothrombin (factor II) in the blood.


Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8

Stage IB includes: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. (AJCC 8th ed.)


Grade 1 Small Bowel Obstruction NOS, CTCAE


Fetus Small for Gestational Age with Abnormal Doppler

A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and has abnormal Doppler studies.


Grade 3 Urine Output Decreased, CTCAE

Adult: Oliguria (<80 ml in 8 hr); Infants: < 0.5 mL/kg per hour for 24 hours; Children: < 500 mL/1.73 m2 body surface area per day


Grade 2 Large Intestinal Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 2 Hypopituitarism, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 5 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Cranial Nerve VIII Neuropathy, CTCAE


Grade 4 Urethra Stricture or Stenosis, CTCAE


Grade 3 Otitis External Ear Non Infectious, CTCAE


Grade 3 Hepatic Pain, CTCAE

Severe pain; limiting self care ADL


Grade 3 Dysesthesia, CTCAE

Severe sensory alteration; limiting self care ADL


Anorgasmia, CTCAE

A disorder characterized by an inability to achieve orgasm.


Grade 5 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic squamous cell carcinoma to skin

A squamous cell carcinoma that has spread to the skin from another anatomic site.


Peripheral neuropathy due to and following antineoplastic therapy

Any disorder affecting the peripheral nerves resulting from exposure to chemotherapeutic agents.


Grade 4 Cranial Nerve XI Intra-Operative Injury, CTCAE


Finding

Clinical, laboratory or molecular evidence, or absence of evidence of disease.


Grade 5 Gastrointestinal Leak NOS, CTCAE


Depression, CTCAE

A disorder characterized by melancholic feelings of grief or unhappiness.


Type I Total Anomalous Pulmonary Venous Return

Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the superior vena cava.


Corneal Ulcer, CTCAE

A disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber.


Grade 3 Thorax Soft Tissue Necrosis, CTCAE


Grade 3 Non-Myocardial Visceral Arterial Ischemia, CTCAE


Childhood Solid Neoplasm

A solid neoplasm (e.g., carcinoma, sarcoma) occurring in children.


Salivary Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic Low Grade Glioma

Low grade glioma that has spread from its primary site to another anatomic site.


Grade 5 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Substance-Induced Persisting Amnestic Disorder

A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the persisting effects of substance use. The memory impairment persists beyond the usual duration of substance intoxication or withdrawal.


Pulmonary Artery Intra-Operative Injury, CTCAE


Grade 3 Cerebral Artery Intra-Operative Injury, CTCAE


Grade 3 Cerebrospinal Fluid Leakage, CTCAE

Severe symptoms; medical intervention indicated


Platinum-Resistant Urothelial Carcinoma

Urothelial carcinoma that is resistant to platinum therapy.


Liver Lymphangiomatosis

Multiple lymphangiomas that affect the liver and other anatomic sites. Although histologically benign, diffuse lymphangiomatosis that affects the liver and multiple organs has a poor prognosis.


Supratentorial Ependymoma, Not Otherwise Specified

A circumscribed ependymoma that arises from the supratentorial region of the brain in which the genetic analysis for fusion genes involving ZFTA or YAP1 genes was unsuccessful or not reported.


Thoracic Nodule

A nodular lesion that develops in the chest wall.


Grade 1 Tongue Intra-Operative Injury, CTCAE


Stage II Merkel Cell Carcinoma AJCC v7

Stage II includes: IIA: (T2/T3, pN0, M0), IIB: (T2/T3, cN0, M0), and IIC: (T4, N0, M0).  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Grade 2 Neck Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pharyngeal Fistula, CTCAE

A disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site.


Mixed subtype adenocarcinoma of lung

The most frequently seen morphologic variant of lung adenocarcinoma characterized by a mixture of architectural patterns, including acinar, papillary, bronchioloalveolar, and solid pattern.


Grade 3 Acute Vascular Leak Syndrome, CTCAE


Vital Exhaustion

A condition characterized by excessive fatigue and lack of energy, increasing irritability, and feelings of demoralization. Persons who experience this condition are not at an increased risk for cancer.


Arachnoiditis, CTCAE

A disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space.


Hemorrhagic cyst

A cyst containing blood.


Grade 4 Lymphocyte Count Decreased, CTCAE

<200/mm3; <0.2 x 10e9/L


Recurrent Anal Canal Squamous Cell Carcinoma

The reemergence of anal canal squamous cell carcinoma after a period of remission.


Grade 2 Other Sexual Reproductive Function, CTCAE


Peripheral Nerve Infection, CTCAE

A disorder characterized by an infectious process involving the peripheral nerves.


Stage IIA1 Cervical Cancer FIGO 2009

Cervical carcinoma limited to the upper two-thirds of the vagina and is equal or less than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Muscle Disorder

A non-neoplastic disorder that affects the smooth, skeletal, or cardiac muscles.


Cranial Nerve Infection, CTCAE

A disorder characterized by an infectious process involving a cranial nerve.


Grade 2 Biliary Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 1 Wheezing, CTCAE

Detectable airway noise with minimal symptoms


Stage III Extragonadal Non-Seminomatous Germ Cell Tumor


Grade 1 Blood Bicarbonate Decreased, CTCAE

<LLN and no intervention initiated


Vaginal Adenoid Basal Carcinoma

A carcinoma that arises from the vagina and is characterized by the presence of nests of basaloid cells with focal glandular formations.


Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 1 Meninges Intra-Operative Injury, CTCAE


Nose Deformities, Acquired

A non-congenital malformation of the nose.


Retinoblastoma by AJCC v8 Stage

A term that refers to the staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition. This staging system does not apply to central nervous system component of "trilateral retinoblastoma" (is staged according to the classification for brain and spinal cord), retinoma (or retinocytoma) (no AJCC staging system), and medulloepithelioma (no AJCC staging system). (from AJCC 8th Ed.)


Serious Adverse Drug Reaction

A noxious and unintended response to a medicinal product occurring at any dose that results in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in a persistent or significant disability/incapacity, or results in a congenital anomaly/birth defect.


Gallbladder Intracholecystic Papillary (Tubular) Neoplasm with Intermediate Grade Intraepithelial Neoplasia

An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of moderate epithelial atypia.


Grade 3 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Bullous Dermatitis, CTCAE

Death


Grade 3 Endophthalmitis, CTCAE

Systemic intervention; hospitalization indicated


Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Unresectable Distal Esophagus Adenocarcinoma

Distal esophagus adenocarcinoma that is not amenable to surgical resection.


Grade 3 Breast Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; severe infection; axillary adenitis


Grade 2 Seroma, CTCAE

Symptomatic; simple aspiration indicated


Recurrent Anaplastic Astrocytoma, IDH-Wildtype

The reemergence of anaplastic astrocytoma, IDH-wildtype after a period of remission.


Grade 3 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Thoracoschisis

A congenital fissure of the thoracic wall.


Grade 4 Edema of the Head and Neck, CTCAE


Grade 3 Hypophosphatemia, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated


Grade 5 Intraoperative Ocular Injury, CTCAE

Death


Grade 2 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intraepithelial Neoplasia in Barrett Esophagus

Glandular intraepithelial neoplasia arising in Barrett esophagus.


Grade 3 Hyperkalemia, CTCAE

>6.0-7.0 mmol/L; hospitalization indicated


Small plaque parapsoriasis

A variant of parapsoriasis in which the plaques are small.


Advanced Digestive System Neuroendocrine Tumor G2

Digestive system neuroendocrine tumor G2 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Chylothorax, CTCAE

Death


Gallbladder Cribriform Carcinoma

A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate with a cribriform growth pattern.


Grade 1 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 2 Anorexia, CTCAE

Oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated


Grade 2 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Aspiration, CTCAE

Altered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen)


Grade 4 Lung Intra-Operative Injury, CTCAE


Parathyroid Intra-Operative Injury, CTCAE


Grade 4 Gastrointestinal Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Accelerated Phase Myeloproliferative Neoplasm

Rapid progression of a myeloproliferative neoplasm, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


Refractory Epstein-Barr Virus-Related Lymphoproliferative Disease with Primary Immunodeficiency

EBV-associated lymphoproliferative disease with primary immunodeficiency that is resistant to treatment.


Overt Primary Myelofibrosis

Primary myelofibrosis characterized by reticulin or collagen fibrosis in the bone marrow. The bone marrow is usually normocellular or hypocellular. Myeloblasts account for less than 10% of the bone marrow cells. Atypical megakaryocytes are present.


Grade 3 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


Grade 1 Serum Amylase Increased, CTCAE

>ULN-1.5 x ULN


Perineal Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus.


Grade 3 Pericarditis, CTCAE

Pericarditis with physiologic consequences (e.g., pericardial constriction)


Flashing Lights, CTCAE

A disorder characterized by a sudden or brief burst of light.


Atelectasis, CTCAE

A disorder characterized by the collapse of part or the entire lung.


Grade 5 Supraventricular Tachycardia, CTCAE

Death


Grade 1 Fever Without Neutropenia, CTCAE


Left Ventricular Diastolic Dysfunction, CTCAE

An adverse event characterized by impaired functioning of the left ventricle of the heart during the diastole phase of the cardiac cycle.


Radiating Chest Pain in Sternum

The location of the radiating chest pain is in the middle of the anterior wall of the thorax, bounded by the clavicles, above, and with the cartilages of the first seven ribs, along the sides.


Reduced WAS Protein Expression

An indication that reduced expression of Wiskott-Aldrich Syndrome protein (WASP; WASp) has been detected in a sample.