Grade 1 Mucosal Infection, CTCAE

Localized, local intervention indicated


Grade 4 Hematoma, CTCAE

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Life-threatening consequences; urgent intervention indicated


Grade 2 Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Laryngeal Inflammation, CTCAE

Severe throat pain; endoscopic intervention indicated


Refractory Glioma

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Glioma that does not respond to treatment.


cytotoxicity

The adverse effect of some iatrogenic therapies. It is an accepted side effect in radiation therapy where the desired effect is to kill rapidly growing tumor cells.  In the killing of tumor cells, other cells that are rapidly growing e.g hair, mucous membranes are also killed.


Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acute Myeloid Leukemia with FUS-ERG

Acute myeloid leukemia associated with FUS-ERG gene fusion. The prognosis is poor.


Grade 1 Uterus Intra-Operative Injury, CTCAE


Splenic marginal zone lymphoma stage III


Clotting of extracorporeal circuit

Thrombus formation within an apparatus that carries blood outside of the body, such as pheresis, dialysis or extracorporeal membrane oxygenation (ECMO).


Grade 5 Cranial Nerve Infection, CTCAE

Death


Grade 4 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Prostate Intra-Operative Injury, CTCAE


Regional Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that has not spread to other regions.


Chronic iridocyclitis

Uveitis that is usually insidious in onset, bilateral, and can be asymptomatic, most often affecting the anterior uveal tract, including the iris and ciliary body, and can result in long-term complications. It is most commonly associated with certain forms of juvenile idiopathic arthritis, but may occur independent of arthritis.


Castration-Sensitive Prostate Carcinoma

Metastatic prostatic carcinoma which is sensitive to androgen-deprivation therapy.


Stage I Adult Diffuse Mixed Cell Lymphoma

Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Grade 2 Blurred Vision, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL


Benign tumor of seminal vesicle

A neoplasm that arises from the seminal vesicle and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Gastrointestinal Anastomotic Leak, CTCAE

Death


Ectopic adrenal cortex

A term that refers to the presence of benign adrenal cortical tissue outside the adrenal glands.


Grade 4 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Vaginal Fistula, CTCAE

A disorder characterized by an abnormal communication between the vagina and another organ or anatomic site.


Portal Vein Thrombosis, CTCAE

A disorder characterized by the formation of a thrombus (blood clot) in the portal vein.


Cervical intraepithelial neoplasia grade 2

Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper half of the squamous epithelium and conspicuous nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal two thirds of the epithelium.


Grade 4 Aortic Valve Disease, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)


Grade 1 Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Prostate cancer stage A

A clinically undetectable tumor confined to the prostate gland, normally an incidental finding during surgery.


Autoimmune Lymphoproliferative Syndrome-Related Lymphoma

A lymphoma that arises in the context of autoimmune lymphoproliferative syndrome.


Grade 5 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Melanotic neurofibroma

A rare neurofibroma characterized by the presence of melanin-laden cells and the absence of atypia.


Grade 2 Vulval Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 2, Children's Oncology Group (COG) Protocol

A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 2 Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol.


Grade 3 Tracheal Mucositis, CTCAE

Severe pain; hemorrhage or respiratory symptoms; limiting self care ADL


Grade 5 Laryngeal Edema, CTCAE

Death


Grade 3 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


Pancreatic Cystic Neoplasm

A benign, borderline, or malignant cystic neoplasm that arises from the exocrine pancreas. This category includes pancreatic mucinous-cystic neoplasms, pancreatic cystadenomas, and pancreatic cystadenocarcinomas.


Grade 1 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Other Musculoskeletal and Soft Tissue, CTCAE


Grade 4 Optic Nerve Disorder, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


astrocytoma, IDH-mutant, grade 4

IDH-mutant astrocytoma characterized by the presence of necrosis and/or microvascular proliferation or homozygous deletion of CDKN2A and/or CDKN2B genes. The term glioblastoma no longer applies to central nervous system WHO grade 4 IDH-mutant astrocytomas. (WHO 2021)


Maturing Ganglioneuroma

A ganglioneuroma characterized by the presence of differentiating neuroblasts, maturing and mature ganglion cells.


Grade 1 Lymph Node Pain, CTCAE

Mild pain


Unresectable Paraganglioma

Paraganglioma that is not amenable to surgical resection.


Prostatic Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the prostate gland.


Stage III Osteosarcoma AJCC v7

Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 1 Fibrinogen Decreased, CTCAE

<1.0-0.75 x LLN; if abnormal, <25% decrease from baseline


Grade 3 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


Grade 3 Amnesia, CTCAE

Severe; long term memory loss; limiting self care ADL


Fever Chills

Shivering secondary to a febrile process.


Grade 3 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Neck NOS Intra-Operative Injury, CTCAE


Nodular Neoplasm

A benign or malignant neoplasm characterized by the formation of nodules by the proliferating neoplastic cells.


Grade 2 Psychosis, CTCAE

Moderate psychotic symptoms (e.g., disorganized speech; impaired reality testing)


Stage IV Adult Diffuse Mixed Cell Lymphoma

Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Grade 3 Hot Flashes, CTCAE

Severe symptoms; limiting self care ADL


Metastatic Childhood Malignant Bone Neoplasm by Toronto Guidelines v2

Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Refractory Acute Myeloid Leukemia with Myelodysplasia-Related Changes

Acute myeloid leukemia, myelodysplasia-related that is resistant to treatment.


Sharp Chest Pain

The sensation of chest pain described as a stabbing feeling.


Pharyngeal Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures).


Bilateral Thalamic Glioma

A glioma affecting both sides of the thalamus.


Grade 2 Nipple Deformity, CTCAE

Symptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex


Solid Angioleiomyoma

A morphologic variant of angioleiomyoma characterized by the presence of numerous small, slit-like vascular channels.


Other Neurology, CTCAE

A finding indicating the presence of multiple pouches, usually in the colonic or gastric wall.


Childhood Pancreatic Acinar Cell Cystadenocarcinoma

An acinar cell cystadenocarcinoma that arises from the pancreas during childhood.


Myeloid Neoplasms with Germline Predisposition and Preexisting Platelet Disorders

Hematologic neoplasms associated with germline mutations and familial platelet disorders.


Conjunctivitis Infective, CTCAE

A disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes.


Primary Neoplasm

A tumor at the original site of origin.


Pathologic Stage IIB Cutaneous Melanoma AJCC v8

Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0). T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 2 Hyperparathyroidism, CTCAE

Moderate symptoms; medical intervention indicated


Adult Acute Promyelocytic Leukemia with PML-RARA

An acute promyelocytic leukemia with t(15;17)(q24.1;q21.2); PML-RARA occurring in adults.


Carcinoma of urinary bladder, invasive

A carcinoma that arises from the bladder mucosa and invades the bladder wall.


Grade 1 Hypomagnesemia, CTCAE

<LLN-1.2 mg/dL; <LLN-0.5 mmol/L


Grade 4 Upper Extremity Vein Intra-Operative Injury, CTCAE


Grade 1 Hyperhidrosis, CTCAE

Limited to one site (palms, soles, or axillae); self care interventions


Infiltrating Cervical Carcinoma

A carcinoma that arises from the cervix and invades into the stromal tissue.


Hyperparathyroidism, CTCAE

A disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood).


Intraoperative injury

Trauma to the body occurring during a surgical intervention.


Invasive Clear Cell (Glycogen-Rich) Urothelial Carcinoma

An invasive urothelial carcinoma characterized by the presence of clear (glycogen-rich) cells.


Proximal Urethral Carcinoma

A carcinoma that arises from the proximal part of the urethra.


Foveolar hyperplasia

A hyperplasia of the gastric foveolar epithelium.


Diffuse Low Grade Glioma, FGFR1 Tyrosine Kinase Domain-Duplicated

Diffuse low-grade glioma characterized by internal tandem duplications of the sequences in the FGFR1 gene encoding the tyrosine kinase domain.


Grade 5 Cervix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Portal Hypertension, CTCAE

Reversal/retrograde portal vein flow; associated with varices and/or ascites


Endometrial Endometrioid Adenocarcinoma with Metaplastic Changes


Hepatocyte Nuclear Factor 1-Alpha Hyperinsulinism

Hyperinsulinism due to mutation(s) in the gene HNF1A, encoding the transcription factor hepatocyte nuclear factor 1-alpha. This condition may progress to diabetes later in life.


Injury of brachial plexus

Damage to the nerves in the brachial plexus network. These nerves originate in the spinal column and innervate the shoulder, arm and hand. Often, damage is sustained from overstretching or motor vehicle accidents.


Localized Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

Tumor confined to area of origin including abdominal lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 3 Pelvis NOS Intra-Operative Injury, CTCAE


Grade 4 Fallopian Tube Obstruction, CTCAE


Grade 1 Gallbladder Intra-Operative Injury, CTCAE


Alanine Aminotransferase Increased, CTCAE

A finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen.


Grade 5 Female Genital Tract Fistula, CTCAE


Antepartum Obstetric Air Embolism

Presence of a large air bubble in the maternal vascular system which originated from a distant site during the antepartum period.


Grade 5 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ischemia Cerebrovascular, CTCAE

A disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage.


Paroxysmal Atrial Tachycardia, CTCAE

A disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria.


Grade 2 Laryngeal Nerve Dysfunction, CTCAE


Examination phobia

An overwhelming, irrational, and persistent fear of taking and failing tests.


Borderline Uterine Ligament Neoplasm

A rare borderline tumor that arises from the broad or other uterine ligaments. The majority of the reported cases are serous cystic tumors.


Progesterone Receptor Status

Indicates the progesterone receptor level measured in a primary tumor or in metastases. (>=10 is positive if measured in fmols/mg cytosol protein; Otherwise use institutional standards)


Adult L1 Acute Lymphoblastic Leukemia

L1 acute lymphoblastic leukemia that occurs during adulthood.


Mucolipidosis Type IIIA

A lysosomal storage disease characterized by multiple bone formation abnormalities, progressive joint stiffness, developmental abnormalities, hearing loss, hepatosplenomegaly, increased acne, enlarged tongue, and cornea clouding due to accumulation of lipid substances.


Posterior Fossa Ependymoma, Not Elsewhere Classified

A circumscribed ependymoma that arises in the posterior fossa in which molecular analysis for DNA methylation profiling cannot assign a molecular group.


Grade 2 Hyponatremia, CTCAE

125-129 mmol/L and asymptomatic


Non-Neoplastic Stomach Disorder

A non-neoplastic disorder that affects the stomach. Representative examples include gastritis and ulcer.


Grade 2 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


Scrotal Infection, CTCAE

A disorder characterized by an infectious process involving the scrotum.


Poorly Differentiated Angiosarcoma

An angiosarcoma characterized by the presence of significant cytologic atypia, necrosis and high mitotic activity.


Grade 3 Lower Extremity Intra-Operative Injury, CTCAE


Papulopustular Rash

Skin eruption consisting of papules and pustules, most often appearing in the face, scalp, and upper trunk.  It is usually caused by corticosteroids or epidermal growth factor receptor inhibitors.


Grade 4 Intraoperative Ocular Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Laryngospasm, CTCAE

Death


Grade 5 Herpes Simplex Reactivation, CTCAE

Death


Genitourinary tract gonococcal infection

A genitourinary infection that is caused by Neisseria gonorrhoeae.


Grade 2 Urethral Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Adult Pineal Gland Astrocytoma

A pineal gland astrocytoma that occurs during adulthood.


Ulcer of nipple

Ulcer that develops in the nipple.  Causes include trauma and Paget disease.


Acquired Unilateral Cataract

A cataract in one eye that results from the aging process, an injury, or as a manifestation of a systemic disorder.


Grade 3 Neonatal Pneumothorax, AE

An adverse event in a newborn characterized by radiological evidence of pneumothorax; with clinical signs; major care change required (e.g. chest drainage).


Grade 4 Gastric Ulcer, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Urethral Pain

A painful sensation in the urethra.


Azoospermia, CTCAE

A disorder characterized by laboratory test results that indicate complete absence of spermatozoa in the semen.


Grade 3 Biliary Tree Common Bile Duct Intra-Operative Injury, CTCAE


High Grade Appendix Mucinous Neoplasm

A rare appendix mucinous neoplasm characterized by the presence of neoplastic epithelial cells with high grade features.


Non-Malignant Pericardial Effusion, CTCAE


Stage IB3 Cervical Cancer AJCC v9

Stage IB3 includes: T1b3, N0, M0. T1b3: Tumor measuring more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 2 Dysgeusia, CTCAE

Altered taste with change in diet (e.g., oral supplements); noxious or unpleasant taste; loss of taste


Bilateral Malignant Neoplasm

A malignant neoplasm that affects both sides of an organ in a simultaneous or non-simultaneous manner.


End stage cardiac failure

The terminal phase of heart failure in patients. The disease course may have progressed despite intervention and may be characterized by dyspnea, fatigue, and weakness.


Thoracic myelocele

Herniation of spinal cord tissue and meninges through a defect in the thoracic region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage II Uterine Corpus Cancer AJCC v6

Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIB (T2b, N0, M0).  T2: Tumor invades cervix but does not extend beyond uterus.  T2a: Tumor limited to the glandular epithelium of the endocervix.  There is no evidence of connective tissue stromal invasion.  T2b: Invasion of the stromal connective tissue of the cervix.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Grade 4 Vitreous Hemorrhage, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Refractory Glioblastoma

A glioblastoma that is resistant to treatment.


Grade 1 Vital Capacity Abnormal, CTCAE

90-75% of predicted value


Prostate Cancer by AJCC v6 Stage

A term that refers to the staging of prostate carcinoma according to the American Joint Committee on Cancer, 6th edition.


Grade 2 Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Benign Liver Epithelial Neoplasm

A neoplasm that arises from the hepatocytes or intrahepatic bile duct epithelial cells and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hepatocellular adenoma and bile duct adenoma.


Grade 5 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Metastatic Endometrial Serous Adenocarcinoma

An endometrial serous adenocarcinoma that has spread to other anatomic sites.


Abdominal and gastrointestinal infections

An infection that affects the gastrointestinal system and the abdomen.


Metastatic Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

Distant metastases present at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Recurrent Uterine Corpus Cancer

The reemergence of uterine corpus cancer after a period of remission.


Pulmonary Valve Disease, CTCAE

A disorder characterized by a defect in pulmonary valve function or structure.


Grade 4 Soft Tissue Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Locally Recurrent Anal Canal Squamous Cell Carcinoma

The reemergence of anal canal squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Lymphangioma circumscriptum

A localized lymphangioma characterized by microcystic changes.


Hyperglucagonemia

Abnormally high levels of glucagon in the blood, which may manifest as hyperglycemia and/or necrolytic migratory erythema.


ADAMTS13 Activity Less than 10 Percent

A finding indicating that the ADAMTS13 activity expressed by a sample is less than 10 percent of the expected value.


Grade 1 Neonatal Hypertension, AE

An adverse event in a newborn characterized by systolic or diastolic blood pressure above the 90th percentile but below the 95th percentile; self-limiting.


Grade 3 Nephrotic Syndrome, CTCAE

Not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Edema Cerebral, CTCAE

New onset; worsening from baseline


Grade 5 Cranial Nerve XI Neuropathy, CTCAE


Glandular intraepithelial neoplasia, low grade


Grade 1 Carbon Monoxide Diffusion Capacity, CTCAE


Grade 2 Breast Atrophy, CTCAE

Moderate asymmetry; moderate atrophy


Grade 2 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Refractory Malignant Mesothelioma

Malignant mesothelioma that is resistant to treatment.


anaplastic carcinoma of ureter

Undifferentiated carcinoma that affects the ureter.


Grade 3 Lingual Nerve Intra-Operative Injury, CTCAE


Grade 3 Fever, CTCAE

>40.0 degrees C (>104.0 degrees F) for <=24 hrs


Defective Mu Heavy Chain Present

An indication that cells expressing a mutated or defective form of immunoglobulin heavy chain mu have been detected in a sample.


Grade 4 Urostomy Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Feminization Acquired, CTCAE

A disorder characterized by the development of secondary female sex characteristics in males due to extrinsic factors.


Abdominal Neoplasm, Excluding Pancreas Neoplasm

A  finding of a neoplastic disease in the abdominal cavity, excluding pancreatic neoplastic disease.


Atypical Small Acinar Proliferation of the Prostate Gland

Focal proliferation of small acinar glandular cells in the prostate gland with cytologic changes ranging from atypia to highly suggestive of malignancy.


Grade 4 Abdomen Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Pharynx Intra-Operative Injury, CTCAE


Stage IV Gastric Cancer AJCC v6

Stage IV includes: (T4, N1-3, M0); (T1-3, N3, M0); (Any T, Any N, M1).  M1:Distant metastasis. (AJCC 6th ed.)


Grade 3 Paronychia, CTCAE

Operative intervention indicated; IV antibiotics indicated; limiting self care ADL


Grade 1 Hypoglossal Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Herpes Simplex Reactivation, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated


Grade 3 Scleral Necrosis and Melt, CTCAE


Invasive Giant Cell Urothelial Carcinoma

An invasive urothelial carcinoma characterized by the presence of giant cells.


Grade 4 Upper Aerodigestive Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Stomach Stricture or Stenosis, CTCAE


Probable Adverse Event Relationship to Product or Procedure

Probable adverse event relationship to study product or procedure is defined when there is a clear-cut temporal association between product or procedure administration and adverse event, and a potential alternative etiology of the event is not apparent.


Prostate Carcinoma Metastatic in the Pelvic Cavity

A carcinoma that arises from the prostate gland and has spread to the pelvic cavity.


Recurrent Oligodendroglioma

The reemergence of oligodendroglioma after a period of remission.


Stage IV Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

Hematogenous metastases or spread beyond abdomen at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 4 Neonatal Respiratory Insufficiency, AE

A respiratory insufficiency adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; requiring urgent care change (e.g. urgent intubation).


Cesarean wound disruption

Asymptomatic separation of the uterine wall, usually at the site of a prior uterine scar, that does not include the overlying serosa.


Male Reproductive System Carcinoma

A malignant neoplasm that arises from the epithelium of any part of the male reproductive system. Representative examples include prostate carcinoma and penile carcinoma.


Affective Disorders, Psychotic

The manifestation of psychotic symptoms, such as hallucinations or delusions, in the presence of a mood disorder.


Holorachischisis

A form of the neural tube defect spina bifida in which the entire spinal column is open.


Diffuse Pediatric-Type High Grade Glioma RTK2

An aggressive, WHO grade 4 diffuse glioma usually affecting children, adolescents, or young adults. It is characterized by receptor tyrosine kinase type 2 (RTK2) alterations.


Stage IV Intermediate Grade Adult Non-Hodgkin's Lymphoma


Exhaustion

A state in which an entity is functionally inept and incapable of exhibiting the usual array of activities.


Grade 5 Guillain-Barre Syndrome, CTCAE

Death


Lugano Classification Stage I Adult Lymphoma AJCC v8

Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Stage III Cervical Cancer AJCC v8

Stage III includes: T3, Any N, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. M0: No distant metastasis. (AJCC 8th Ed.)


Laboratory Test Toxicity

A laboratory test designed to quantify or qualify the poisonous nature of a sample.


Grade 2 Pneumothorax, CTCAE

Symptomatic; intervention indicated


Squamous cell carcinoma, large cell, nonkeratinizing

A squamous cell carcinoma composed of large atypical cells, without morphologic evidence of keratin production.


Stage II Esophageal Cancer

Stage II includes: IIA: (T2, N0, M0); (T3, N0, M0) and IIB: (TI, NI, M0); (T2, NI, M0).  TI: Tumor invades lamina propria or submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) -2003


Conjunctivitis, CTCAE

A disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye.


Benign Lacrimal Drainage System Neoplasm

A neoplasm that arises from the lacrimal drainage system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Hepatobiliary Inflammation

An inflammatory process affecting the liver, bile ducts and gallbladder.


Grade 3 Brachial Plexopathy, CTCAE

Severe symptoms; limiting self care ADL


Grade 2 Urostomy Stenosis, CTCAE

Symptomatic but no hydronephrosis, sepsis, or renal dysfunction; dilation or endoscopic repair or stent placement indicated


Gastroesophageal Junction Adenocarcinoma by AJCC v8 Clinical Stage

A term that refers to the clinical staging of gastroesophageal junction adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Grade 4 Non-Malignant Pleural Effusion, CTCAE


Grade 5 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

Death


Diffuse Midline Glioma, EGFR-Mutant

A diffuse midline glioma, H3 K27-altered, characterized by the presence of EGFR gene mutation.


Grade 5 Erythema Multiforme, CTCAE

Death


autosomal recessive dyskeratosis congenita 3

Dyskeratosis congenita caused by autosomal recessive mutation(s) in the WRAP53 gene, encoding telomerase Cajal body protein 1.


Grade 2 Phrenic Nerve Dysfunction, CTCAE


Stage IIIC2 Cervical Cancer AJCC v9

Stage IIIC2 includes: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 9th Ed.)


Endobronchial Nodule

A nodule entirely contained within a bronchus; it may obstruct the airway, but does not breach the bronchial wall.


Breast Adenohibernoma

A breast hamartoma characterized by the presence of brown fat that contains entrapped glands.


Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

An acute lymphoblastic leukemia that originates from pre-B lymphocytes. The pre-B lymphoblasts contain cytoplasmic immunoglobulin.


Grade 5 Ovarian Hemorrhage, CTCAE

Death


Grade 1 Burn, CTCAE

Minimal symptoms; intervention not indicated


Grade 4 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Stage IIA Prostate Cancer AJCC v8

Stage IIA includes: (cT1a-c, cT2a, N0, M0, PSA equal or more than 10 and less than 20, Grade Group 1); (cT2b-c, N0, M0, PSA less than 20, Grade Group 1). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. cT2b: Prostate cancer in which the tumor involves more than one-half of one side but not both sides. cT2c: Prostate cancer in which the tumor involves both sides. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. (AJCC 8th ed.)


Anal Cancer by AJCC v8 Stage

A term that refers to the staging of anal cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to all carcinomas arising in the anal canal, including carcinomas that arise within anorectal fistulas and those arising in the perianal area (anal margin). High-grade neuroendocrine carcinomas (small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma) are staged using this system. There is no AJCC staging system for anal mucosal melanomas and anal well-differentiated neuroendocrine tumors. (from AJCC 8th Ed.)


Well Differentiated Prostate Adenocarcinoma

An invasive prostate adenocarcinoma characterized by the presence of well differentiated malignant glandular epithelial components.


Primary Cutaneous Hodgkin Lymphoma

Hodgkin lymphoma primarily involving the skin.  This diagnosis can only be made when there is no evidence of Hodgkin lymphoma in the lymph nodes or other anatomic sites.  Patients usually present with papules or nodular lesions.  Morphologically, primary cutaneous Hodgkin lymphoma may resemble lymphomatoid papulosis or anaplastic large cell lymphoma.  Immunohistochemical tissue evaluation is essential in establishing the diagnosis.


Grade 5 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Stroke, CTCAE

A disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage.


Grade 5 Pancreatitis, CTCAE

Death


Grade 3 Blood Antidiuretic Hormone Abnormal, CTCAE

Hospitalization indicated


Human Papillomavirus-Related Cervical Adenocarcinoma

A cervical adenocarcinoma associated with the presence of human papillomavirus infection.


Mucocele of gallbladder

The enlargement of the gallbladder secondary to prolonged obstruction of the cystic duct.


Grade 1 Erectile Dysfunction, CTCAE

Decrease in erectile function (frequency or rigidity of erections) but intervention not indicated (e.g., medication or use of mechanical device, penile pump)


Grade 4 Small Bowel NOS Intra-Operative Injury, CTCAE


Biliary Tract Carcinoma

A carcinoma arising from the intrahepatic bile ducts, hepatic ducts, common bile duct, cystic duct, or gallbladder.


Pancreatic Teratoma

A teratoma that arises from the pancreas.


Tobacco Induced Hyperparakeratosis

Hyperparakeratosis of the oral mucosa caused by chronic tobacco use.  It manifests as oral leukoplakia.


Locally Advanced Endometrioid Adenocarcinoma

Endometrioid adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Sinusoidal Obstruction Syndrome, CTCAE

Blood bilirubin 2-5 mg/dL; minor interventions required (i.e., blood product, diuretic, oxygen)


Grade 2 Prolapse of Gastrointestinal Stoma, CTCAE


Grade 2 Cardiac Ischemia or Infarction, CTCAE


Grade 2 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Upper Gastrointestinal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 Small Intestinal Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


COL1A1 Associated Connective Tissue Disorder

A group of connective tissue disorder caused by mutations in the COL1A1 gene mapped to chromosome 17q21. It includes the Ehlers-Danlos syndrome, osteogenesis imperfecta, and osteoporosis.


Stage 0 Esophageal Cancer AJCC v6

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.)


Grade 1 Fallopian Tube Anastomotic Leak, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Splenic Infection

An infectious process affecting the spleen. Predisposing factors include immunosuppression, diabetes mellitus, and sickle cell anemia. Infectious agents include bacteria (e.g., staphylococcus and streptococcus) and fungi.


Grade 2 CNS Cerebrovascular Ischemia, CTCAE


Grade 5 Encephalitis Infection, CTCAE

Death


High Grade Corneal Squamous Intraepithelial Neoplasia

A precancerous neoplastic intraepithelial process with high-grade dysplastic features involving the corneal epithelium.


Grade 2 Kidney Intra-Operative Injury, CTCAE


Grade 2 Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


Skin Verrucous Carcinoma

A verrucous carcinoma that arises from the skin. It usually affects the palms, soles, and distal digits.


Glucose-6-Phosphatase 3 Deficiency

An autosomal recessive inherited disorder caused by mutations in the G6PC3 gene. It is characterized by the absence or presence of very low levels of glucose-6-phosphatase 3. Patients may develop severe congenital neutropenia.


Conventional Follicular Dendritic Cell Sarcoma

Follicular dendritic cell sarcoma that is not associated with Epstein-Barr virus.


Grade 4 Small Bowel Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Breast fibroadenolipoma

A benign, circumscribed and usually encapsulated lesion of the breast.  It contains all the components of the breast tissue.


Prostate Intraductal Carcinoma

An intra-acinar and/or intraductal neoplastic epithelial proliferation in the prostate gland that has some features of high-grade prostatic intraepithelial neoplasia but exhibits much greater architectural and/or cytological atypia, typically associated with high-grade, high-stage prostate carcinoma. (WHO 2016)


Resectable Osteosarcoma

Osteosarcoma that is amenable to surgical resection.


Ionizing Radiation-Related Malignant Neoplasm

A malignant neoplasm arising in an anatomic site exposed to ionizing radiation.


Grade 5 Injury To Inferior Vena Cava, CTCAE

Death


Dry Skin, CTCAE

A disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture.


Fascial fibrosarcoma

A malignant fibroblastic neoplasm arising from the fascial connective tissue.


Transplant-Related Bladder Urothelial Carcinoma

A bladder urothelial carcinoma that arises in a patient with a history of organ transplantation.


Serum Prostate Specific Antigen Increased


Grade 5 Local Complication of Device and Prosthesis, CTCAE


Vaginal Basaloid Carcinoma

A squamous cell carcinoma that arises from the vagina and is characterized by the presence of nests of malignant basaloid squamous cells with scant amounts of cytoplasm.


Grade 2 Phlebitis, CTCAE

Present


Ventral Hernia with Obstruction without Mention of Gangrene

The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, which results in obstruction, without mention of necrosis of the herniated contents.


Autosomal Dominant Neurohypophyseal Diabetes Insipidus

An autosomal dominant form of diabetes insipidus caused by mutation(s) in the AVP gene encoding arginine vasopressin.


Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Vaginal Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Advanced Bone Sarcoma

A bone sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Lipid-Rich Urothelial Carcinoma

Lipid-rich urothelial carcinoma that has spread to another anatomic site.


Stage IV Fallopian Tube Cancer AJCC v8

Stage IV includes: Any T, Any N, M1: M1: Distant metastasis, including pleural effusion with positive cytology; liver or splenic parenchymal metastasis; metastasis to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); and transmural involvement of intestine. (from AJCC 8th Ed.)


Adverse Event Associated with the Ear and Auditory System


Grade 3 Ileal Fistula, CTCAE

Invasive intervention indicated


Decreased PARP Enzyme Activity

A finding indicating that a sample is expressing lower levels of poly [ADP-ribose] polymerase enzyme activity than that expressed by a reference or comparative sample.


Grade 3 Intraoperative Splenic Injury, CTCAE

Resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Recurrent Vulvar Squamous Cell Carcinoma

The reemergence of vulvar squamous cell carcinoma after a period of remission.


Grade 2 Lymphedema-Related Fibrosis, CTCAE


Grade 4 Ophthalmoplegia and Diplopia, CTCAE


Metastatic Anal Carcinoma

Anal carcinoma that has spread from its primary site to another anatomic site.


Undifferentiated Fallopian Tube Carcinoma

An invasive carcinoma arising from the fallopian tube. It is characterized by the presence of a diffuse malignant infiltrate that is composed of epithelial cells without evidence of glandular or squamous differentiation.


Grade 2 Uterus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Transfusion dependent thalassaemia

Thalassemia that results in severe anemia and requires regular blood transfusions for patient survival.


Metastatic malignant neoplasm to nervous system

The spread of a malignant neoplasm to the nervous system.  This may be from a primary nervous system malignant neoplasm, or from a malignant neoplasm at a distant site.


Grade 3 Small Bowel Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage III Childhood Hodgkin Lymphoma by Toronto Guidelines v2

Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


large cell neuroendocrine carcinoma of anal canal

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal.  It is characterized by the presence of malignant large cells.


Hilar Mass

An abnormal growth located in the hilum of the lung.


Appendix Mucinous Neoplasm

An appendiceal neoplasm characterized by mucinous epithelial proliferation with extracellular mucin and pushing tumour margins. (WHO 2019)


Grade 5 Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Primary Immune Regulatory Disorder

A group of immune diseases characterized predominantly by immune dysregulation leading to organ-specific autoimmunity, excessive inflammation, and non-malignant lymphoproliferation. Unlike classical primary immunodeficiencies, susceptibility to infections is typically less prominent in these disorders.


acute myelomonocytic leukemia in relapse

The reemergence of acute myelomonocytic leukemia after a period of remission.


Bile Duct Intraductal Papillary Neoplasm with Intermediate Grade Intraepithelial Neoplasia

An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of moderate epithelial atypia.


Grade 4 Tumor Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage IVA Fallopian Tube Cancer AJCC v8

Stage IVA includes: Any T, Any N, M1a. M1a: Fallopian tube cancer with pleural effusion with positive cytology. (from AJCC 8th Ed.)


Retinoma

A rare, unilateral or bilateral benign neoplasm that arises from the retina. There is an increased risk of malignant transformation to retinoblastoma; therefore, patients with a diagnosis of retinocytoma should be closely observed.


Intra-Abdominal Lymphangioma

A lymphangioma arising from the organs of the abdominal cavity.


Grade 5 Infusion Site Extravasation, CTCAE

Death


Grade 3 White Blood Cell Decreased, CTCAE

<2000-1000/mm3; <2.0-1.0 x 10e9/L


Extrahepatic Bile Duct Neuroendocrine Neoplasm

A neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Flashing Lights and Floaters in Vision, CTCAE


Epithelioid Malignant Peripheral Nerve Sheath Tumor of the Skin

An epithelioid malignant peripheral nerve sheath tumor that arises from the skin.


Refractory Brain Neoplasm

Brain neoplasm that is resistant to treatment.


Grade 2 Psychiatric Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 4 Upper Extremity Intra-Operative Injury, CTCAE


Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Extracutaneous Merkel Cell Carcinoma

An extremely rare Merkel cell carcinoma affecting the lymph nodes. It may represent metastasis from a regressed dermal primary. (WHO 2017)


Stage I Childhood Hodgkin Lymphoma by Toronto Guidelines v2

Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. This definition applies to both tiers (tier 1 and 2).  (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 1 Electrocardiogram T Wave Abnormal, CTCAE

T wave flattening


Adenocarcinoma in situ in a polyp

An adenocarcinoma arising in a polyp.


Injury of ovary

Trauma to an ovary.


Grade 5 Jejunal Stenosis, CTCAE

Death


Grade 4 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Cranial Nerve VI Neuropathy, CTCAE


Grade 3 Stomal Ulcer, CTCAE

Severe symptoms; elective operative intervention indicated


Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Corneal Infection, CTCAE

Death


Death Not Associated with More Specific Term, CTCAE


Grade 3 Cranial Nerve IX Neuropathy, CTCAE


Skin Hypopigmentation, CTCAE

A disorder characterized by loss of skin pigment (e.g., vitiligo).


Appendix Tubular Adenoma

An adenoma arising from the appendix.  It is characterized by the presence of tubular epithelial structures and it is associated with dysplasia.


Refractory Childhood Acute Myeloid Leukemia

Childhood acute myeloid leukemia that does not respond to treatment.


Grade 2 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acute Myeloid Leukemia with t(11;19)(q23.3;p13.3); KMT2A-MLLT1

An acute myeloid leukemia associated with t(11;19)(q23.3;p13.3) resulting in KMT2A-MLLT1 gene fusion. It usually affects infants and children.


Annoying Pain

A sensation of discomfort or distress that is bothersome and irritating.


Grade 3 Right Ventricular Dysfunction, CTCAE

Severe symptoms, associated with hypoxia, right heart failure; oxygen indicated


Grade 2 Vein Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Intraoperative Splenic Injury

Damage to the spleen during a surgical procedure.


Indolent T-Lymphoblastic Proliferation

A non-neoplastic T-cell lymphoproliferation that may mimic T-lymphoblastic lymphoma. It usually involves the lymphoid tissues of the upper aerodigestive tract. It recurs locally, but systemic dissemination is rare.


Grade 2 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Small Bowel Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Stage IIB Esophageal Adenocarcinoma AJCC v7

Stage IIB includes: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent Acute Myeloid Leukemia with t (9;11) (p21.3; q23.3); MLLT3-MLL

The reemergence of acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A after a period of remission.


Grade 3 Malabsorption, CTCAE

Inability to aliment adequately; TPN indicated


Grade 5 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Recurrent Lymphoproliferative Disorder

The reemergence of a lymphoproliferative disorder after a period of remission.


Recurrent Digestive System Carcinoma

The reemergence of carcinoma in any part of the digestive system after a period of remission.


Blennorrhagic arthritis

A form of reactive arthritis that is associated with lesions on both the palms of the hands and the soles of the feet.


Metastatic Distal Esophagus Adenocarcinoma

Distal esophagus adenocarcinoma that has spread from its original site of growth to another anatomic site.


Invasive Bladder Urothelial Carcinoma with Glandular Differentiation

An invasive urothelial carcinoma of the bladder that exhibits glandular differentiation.


Grade 2 Optic Nerve Disorder, CTCAE

Moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


Myelophthisis

A condition resulting from the destruction of bone marrow precursor cells and their stroma. Bone marrow is displaced by fibrosis, tumors, or granulomas.


Jejunal Hemorrhage, CTCAE

A disorder characterized by bleeding from the jejunal wall.


Congenital Unilateral Cataract

Cataract in one eye that is present at birth.


Grade 4 Blurred Vision, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Grade 4 Otitis External Ear Non Infectious, CTCAE


Keratitis caused by infection

Inflammation of the cornea secondary to an infectious process.


Craniopharyngioma malignant

A rare condition characterized by the development of a carcinoma in a pre-existing craniopharyngioma.


Grade 2 Neonatal Edema, AE

An adverse event in a newborn characterized by moderate edema; no change in age appropriate behavior; requiring minor care changes (e.g. alteration in fluid management).


Stage III Adult Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 2 External Ear Pain, CTCAE

Moderate pain; limiting instrumental ADL


Localized Carcinoma

A carcinoma that is confined to a specific site without evidence of spread to other anatomic sites.


Stage I Adult Diffuse Large Cell Lymphoma

Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Grade 3 Female Genital Tract Fistula, CTCAE


Gastric Pylorus Carcinoma In Situ AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Hodgkin's disease, nodular sclerosis - mixed cellularity

Nodular sclerosis Hodgkin lymphoma in which at least 75% of the tumor nodules contain scattered Reed-Sternberg cells. The background cellular infiltrate is lymphocytic, mixed, or fibrohistiocytic.


Grade 2 Testicular Disorder, CTCAE

Symptomatic but not interfering with sexual function; intervention not indicated; limiting instrumental ADL


Recurrent T-Cell Prolymphocytic Leukemia

The reemergence of T-cell prolymphocytic leukemia after a period of remission.


Grade 1 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Cheilognathouranoschisis

A congenital abnormality consisting of a fissure in the midline of the lip, hard and/or soft palate and upper jaw.


Lymphocyte Predominant Type Hodgkin's Disease

An antiquated term that refers either to nodular lymphocyte predominant Hodgkin lymphoma or to lymphocyte-rich classical Hodgkin lymphoma.


Fetomaternal Transfusion

Loss of fetal blood into the maternal circulation.


Cerebellar Peduncle Neoplasm

A benign or malignant neoplasm that affects the cerebellar peduncle.


Grade 5 Neuroendocrine ADH Secretion Abnormality, CTCAE


Grade 2 Memory Impairment, CTCAE

Moderate memory impairment; limiting instrumental ADL


Grade 4 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Lymph Gland Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Anal Hidradenoma Papilliferum

A benign neoplasm arising from the perianal sweat glands. It presents as a cystic nodular lesion and is characterized by the presence of cystic and papillary structures. The papillary structures contain connective tissue and are covered by two layers of epithelium.


Metastatic Low Grade Astrocytoma

Low grade astrocytoma that has spread from its primary site to another anatomic site.


Clonal Monocytosis of Undetermined Significance

A myelodysplastic/myeloproliferative neoplasm characterized by the presence of persistent monocytosis, presence of at least one myeloid neoplasm-associated mutation, absence of significant dysplasia or increased blasts in the bone marrow, absence of morphologic findings suggestive of chronic myelomonocytic leukemia in the bone marrow, and absence of history of a reactive condition that would explain the persistent monocytosis.


Grade 3 Gastrointestinal Stoma Hemorrhage, CTCAE


Grade 1 Urostomy Site Bleeding, CTCAE

Minimal bleeding identified on clinical exam; intervention not indicated


Recurrent Vulvar Carcinoma

The reemergence of vulvar carcinoma after a period of remission.


Grade 4 Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Acute Kidney Injury, CTCAE

Life-threatening consequences; dialysis indicated


Grade 2 Peripheral Ischemia, CTCAE

Brief (<24 hrs) episode of ischemia managed medically and without permanent deficit


Heart Failure, CTCAE

A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure.


Pathologic Stage 0 Merkel Cell Carcinoma AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: In situ primary tumor. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Grade 4 Anus Stricture or Stenosis, CTCAE


Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Atrial Flutter, CTCAE

Death


Grade 5 Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Kidney Intra-Operative Injury, CTCAE


Grade 2 Postnasal Drip, CTCAE

Moderate symptoms; medical intervention indicated


Hodgkin's disease lymphocyte depletion type recurrent

The reemergence of lymphocyte-depleted classic Hodgkin lymphoma after a period of remission.


Stage IB1 Cervical Cancer AJCC v9

Stage IB1 includes: T1b1, N0, M0. T1b1: Tumor measuring more than 5 mm in depth and equal or less than 2 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Locally Advanced Carcinoid Tumor

A carcinoid tumor that has spread to nearby tissues or lymph nodes.


Gemistocytic Astrocytoma, IDH-Mutant

Gemistocytic astrocytoma carrying IDH mutations.


Grade 1 Central Nervous System Hemorrhage, CTCAE


Pathologic Stage IV Merkel Cell Carcinoma AJCC v8

Stage IV includes: T0-4, Any N, M1. T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. M1: Distant metastasis microscopically confirmed. (AJCC 8th ed.)


Grade 1 Cervix Intra-Operative Injury, CTCAE


Grade 1 Anal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 3 Bronchus Intra-Operative Injury, CTCAE


Grade 4 Pituitary Intra-Operative Injury, CTCAE


Vaginal Papillary Carcinoma

A rare squamous cell carcinoma that arises from the vagina resembling transitional cell carcinoma of the urinary tract.


Refractory Fallopian Tube Transitional Cell Carcinoma

Fallopian tube transitional cell carcinoma that is resistant to treatment.


Grade 4 Obstruction Gastric, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Localized Malignant Solid Neoplasm

A malignant solid neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Metabolism and Nutrition Disorders - Other, Specify, CTCAE


Grade 4 Nose Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Serum Immunoglobulin Free Light Chain Increased

A laboratory test result indicating higher than normal levels of immunoglobulin free light chain in the serum.


Grade 5 Respiratory Tract Hemorrhage NOS, CTCAE


Grade 5 Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Cholesterol High, CTCAE

>ULN-300 mg/dL; >ULN-7.75 mmol/L


Grade 5 Cytomegalovirus Infection Reactivation, CTCAE

Death


Stage II Bladder Cancer AJCC v8

Stage II includes: (T2a, N0, M0); (T2b, N0, M0). T2a: Tumor invades superficial muscularis propria (inner half). T2b: Tumor invades deep muscularis propria (outer half). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Idiopathic Ketotic Hypoglycemia

Ketotic hypoglycemia that usually occurs in young, thin children in association with infection or fasting, and which typically resolves by age 6-8 years.


Esophageal Varices Hemorrhage, CTCAE 3.0


Stage IIIA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 2 Rash Maculo-Papular, CTCAE

Macules/papules covering 10-30% BSA with or without symptoms (e.g., pruritus, burning, tightness); limiting instrumental ADL; rash covering > 30% BSA with or without mild symptoms


Grade 2 Oral Dysesthesia, CTCAE

Moderate pain; interfering with oral intake


Lacrimal Drainage System Exophytic Papilloma

A benign exophytic papillary neoplasm that arises from the lacrimal drainage system. It consists of fibrovascular cores lined by epithelial cells.


Grade 2 Gastric Ulcer, CTCAE

Symptomatic; altered GI function; medical intervention indicated; limiting instrumental ADL


Abnormal Blood Chemistry and Hematology Test Result

A laboratory test result that indicates the presence of abnormal blood chemistry and/or hematology values.


Grade 5 Ventricular Tachycardia, CTCAE

Death


Grade 4 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Hodgkin's disease mixed cellularity stage I subdiaphragmatic


Beta-2 Microglobulin Greater than 5.5 g/mL

A laboratory test result indicating the presence of high levels of beta-2 microglobulin in blood or urine, exceeding 5.5 g/mL.


Anal infection

An infectious process affecting the anal area.


Grade 1 Encephalopathy, CTCAE

Mild symptoms


Grade 4 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Reserve Cell Hyperplasia

Hyperplasia of the immature cells located between the surface columnar epithelium and the basal layer.


Grade 3 Pleural Hemorrhage, CTCAE

>1000 ml of blood evacuated; persistent bleeding (150-200 ml/hr for 2-4 hr); persistent transfusion indicated; elective operative intervention indicated; hospitalization


Physical Entrapment

Patient becomes entangled or caught in a bed, particularly in side rails, or mattress, or head/foot boards.


Hodgkin's Disease, Lymphocyte Depletion, Reticular

A lymphocyte depleted Hodgkin lymphoma characterized by the presence of reticular fibrosis.


Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Limited stage Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Restlessness, CTCAE

A disorder characterized by an inability to rest, relax or be still.


Neuroendocrine ADH Secretion Abnormality, CTCAE


Lacrimal Gland Acinic Cell Carcinoma

An extremely rare, low-grade, salivary gland-type carcinoma that arises from the lacrimal gland. It exhibits acinar differentiation.


Grade 2 Cranial Nerve V Neuropathy, CTCAE


Grade 2 Hypothyroidism, CTCAE

Symptomatic; thyroid replacement indicated; limiting instrumental ADL


Urethral Infection

A bacterial, viral, or fungal infectious process affecting the urethra.


Biliary Intraepithelial Neoplasia-2

Biliary intraepithelial neoplasia characterized by the presence of moderate epithelial atypia.


Recurrent Malignant Brain Neoplasm

The reemergence of a malignant brain neoplasm after a period of remission.


Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 1 Hallucinations, CTCAE

Mild hallucinations (e.g., perceptual distortions)


Injection site thrombophlebitis

Thrombophlebitis in the veins surrounding an injection site.


Refractory Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Accelerated phase chronic myeloid leukemia, BCR-ABL1 positive that is resistant to treatment.


Rare Diseases

A disease that affects fewer than 200,000 people in the United States.


Microvascular Thrombosis Related to COVID-19

Blood clot formation in the small blood vessels of the body in a patient with probable or confirmed acute COVID-19.


Ann Arbor Stage II Lymphocyte-Depleted Classic Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 5 Ureteric Anastomotic Leak, CTCAE

Death


Grade 2 Alkaline Phosphatase Increased, CTCAE

>2.5-5.0 x ULN if baseline was normal; >2.5-5.0 x baseline if baseline was abnormal


Prosthetic Valve Thrombosis

The formation of a blood clot that is attached to or near an artificial heart valve; this can cause dysfunction of the valve, and possibly lead to an embolic event should the thrombus become dislodged.


Grade 3 Postoperative Hemorrhage, CTCAE

Transfusion indicated of >=2 units (10 cc/kg for pediatrics) pRBCs; invasive intervention indicated; hospitalization


Vulvar Dysplastic Melanocytic Nevus

A rare, elevated and pigmented, compound or junctional nevus that arises from the vulva. It affects women in their reproductive years and may be associated with the presence of dysplastic nevi in other anatomic areas. It is characterized by the presence of epithelioid or spindle-shaped melanocytes exhibiting nuclear pleomorphism and prominent nucleoli.


Grade 4 Conjunctivitis, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


Grade 5 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Hepatitis B Reactivation, CTCAE

Life-threatening consequences; urgent intervention indicated; severe decompensated liver function (e.g., coagulopathy, encephalopathy, coma)


Borderline Ovarian Serous Papillary Cystic Tumor

A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of papillary proliferations of atypical serous epithelial cells and a cystic component.  There is no evidence of stromal invasion.


Vaginal Perforation, CTCAE 5.0

A disorder characterized by a rupture in the vaginal wall.


Grade 3 Upper Extremity Vein Intra-Operative Injury, CTCAE


Unresectable Malignant Gastric Neoplasm

A malignant gastric neoplasm that is not amenable to surgical resection.


Pain of Skin, CTCAE

A disorder characterized by a sensation of marked discomfort in the skin.


Grade 3 Eye NOS Intra-Operative Injury, CTCAE


Grade 3 Intraoperative Head and Neck Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 1 Non-Malignant Pleural Effusion, CTCAE


Grade 3 Oral Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 Splenic Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Invasive Bladder Urothelial Carcinoma with Trophoblastic Differentiation

An invasive bladder urothelial carcinoma characterized by the presence of trophoblastic differentiation.


Metastatic NUT Carcinoma

NUT carcinoma that has spread from its original site of growth to another anatomic site.


Peritoneal Sarcomatosis

A condition in which a sarcoma has spread extensively throughout the peritoneum.


Vaginal Infection, CTCAE

A disorder characterized by an infectious process involving the vagina.


Grade 3 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Hemolysis, CTCAE

A disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction.


Dehiscence

A splitting open of an anatomical structure, zone, or organ with the exposure or discharge of its content.


Grade 5 Ileal Fistula, CTCAE

Death


Grade 2 Cranial Nerve IX Neuropathy, CTCAE


Diffuse Midline Glioma, H3 K27-Altered

A diffuse midline glioma characterized by H3 K27 alteration and usually either a histone H3 K27M mutation, an EGFR mutation, or aberrant overexpression of EZHIP. The prognosis is poor.


Refractory WHO Grade 2 Glioma

WHO grade 2 glioma that is resistant to treatment.


Grade 5 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Cecum Intra-Operative Injury, CTCAE


Metastatic Bladder Plasmacytoid Urothelial Carcinoma

Bladder plasmacytoid urothelial carcinoma that has spread to another anatomic site.


Grade 2 Gait Disturbance, CTCAE

Moderate change in gait (e.g., wide-based, limping or hobbling); assistive device indicated; limiting instrumental ADL


IgM Monoclonal Gammopathy of Undetermined Significance, Plasma Cell Type

A subtype of IgM monoclonal gammopathy of undetermined significance characterized by the presence of clonal plasma cells, absence of clonal B-lymphocytes, and absence of MYD88 gene mutation. The t(11;14)(q13;q32) is present in some cases. This subtype is considered a precursor of multiple myeloma.


Small Intestine Ulcer, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the small intestine.


Unresectable Digestive System Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from any part of the digestive system and is not amenable to surgical resection.


Grade 2 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Chest Pain in Right Second Intercostal Space

The location of the chest pain is within the second intercostal space on the right side.


Non-Neoplastic Mediastinal Disorder

A non-neoplastic disorder that affects the structures of the mediastinum.  Representative examples include mediastinitis and thymic hyperplasia.


Grade 5 Hyperthyroidism, CTCAE

Death


Grade 4 Left Ventricular Systolic Dysfunction, CTCAE

Refractory or poorly controlled heart failure due to drop in ejection fraction; intervention such as ventricular assist device, intravenous vasopressor support, or heart transplant indicated


Grade 1 Fibrosis-Deep Connective Tissue, CTCAE


Grade 5 Hypocalcemia, CTCAE

Death


Grade 3 Tremor, CTCAE

Severe symptoms; limiting self care ADL


Chills, CTCAE

A disorder characterized by a sensation of cold that often marks a physiologic response to sweating after a fever.


Hair Color Changes, CTCAE

A disorder characterized by change in hair color or loss of normal pigmentation.


Childhood Digestive System Neoplasm

A neoplasm that affects any part of the digestive system and occurs during childhood.


Mixed Trophoblastic Tumor

A gestational trophoblastic tumor characterized by the presence of two or three histological types of gestational trophoblastic tumor, including choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor.


Grade 3 Infertility and Sterility, CTCAE


Stage 0 Gallbladder Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Neuropathy, Recurrent, with Pressure Palsies

An autosomal dominant condition caused by mutation(s) in the PMP22 gene, encoding peripheral myelin protein 22. Neuropathy is precipitated by mechanical compression on a nerve, typically with onset in the first and second decades.


Grade 4 Upper Extremity Artery Injury, CTCAE


Grade 4 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Vomiting, CTCAE

Death


Stage III Merkel Cell Carcinoma AJCC v7

Stage III includes: IIIA: (Any T, N1a, M0) and IIIB: (Any T, N1b/N2, M0).  N1a: Micrometastasis in regional lymph nodes.  N1b: Macrometastasis in regional lymph nodes.  N2: In transit metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Stage IIA Gallbladder Cancer AJCC v8

Stage IIA includes: T2a, N0, M0. T2a: Tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Infections and Infestations - Other, Specify, CTCAE

Death


Fibrohistiocytic Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes, in a storiform pattern.


Grade 1 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 3 Skin Intra-Operative Injury, CTCAE


Stage IIB Cervical Cancer AJCC v9

Stage IIB includes: T2b, N0, M0. T2b: Tumor with parametrial invasion but not up to the pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Unresectable Sarcoma

A sarcoma which is not amenable to surgical resection.


Grade 3 Hepatic Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Decreased NCF1 Expression

An indication that the expression of NCF1 is lower than the normal range of values.


Grade 4 Infant Irritability, AE

An adverse event in a newborn characterized by life threatening irritability, with loss of autonomic control of temperature or heart rate; requiring urgent care change.


Smoldering Systemic Mastocytosis with an Associated Hematological Neoplasm

Smoldering systemic mastocytosis associated with the presence of a clonal non-mast cell myeloid neoplasm (e.g., myelodysplastic syndrome,  myeloproliferative neoplasm, and acute myeloid leukemia).


Human papillomavirus negative squamous cell carcinoma

A squamous cell carcinoma not associated with human papilloma virus infection.


Stage II Cervical Cancer AJCC v6

Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIB (T2b, N0, M0). T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion. T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Grade 3 Small Intestinal Perforation, CTCAE

Invasive intervention indicated


Grade 2 Cranial Nerve IV Neuropathy, CTCAE


Grade 3 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Jejunal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Recurrent Anal Mucinous Adenocarcinoma

The reemergence of anal mucinous adenocarcinoma after a period of remission.


Prostate Cancer by AJCC v7 Stage

A term that refers to the staging of prostate carcinoma according to the American Joint Committee on Cancer, 7th edition.


PALB2-Associated Malignant Neoplasm

A malignant neoplasm caused by deleterious germline mutation in the PALB2 gene. This mutation is associated with the development of breast carcinoma and pancreatic carcinoma.


Maternal Proteinuria

The presence of excessive protein, chiefly albumin but also globulin, in the urine of a pregnant woman.


Grade 1 Renal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Liver Neuroendocrine Tumor G1

A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the liver. The mitotic count is less than 2 per 10 HPF.


Rare Malignant Solid Neoplasm

A malignant solid neoplasm with an annual incidence of less than 6 per 100,000 people.


Pancreatic Moderately Differentiated Ductal Adenocarcinoma

A pancreatic ductal adenocarcinoma characterized by the presence of medium-sized duct-like structures and small malignant tubular glandular structures.


Grade 3 Tumor Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Cervix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Paresthesia, CTCAE

A disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and/or warmth.


Grade 1 Neonatal Convulsion, AE

An adverse event in a newborn characterized by a single, self-limited suspected seizure requiring no treatment.


Grade 2 Gastroesophageal Reflux Disease, CTCAE

Moderate symptoms; medical intervention indicated


Grade 3 Hypercalcemia, CTCAE

Corrected serum calcium of >12.5-13.5 mg/dL; >3.1-3.4 mmol/L; Ionized calcium >1.6-1.8 mmol/L; hospitalization indicated


Esophageal Cancer by AJCC v7 Stage

A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 7th edition.


Grade 5 Uterine Hemorrhage, CTCAE

Death


Personality and Behavioral Change, CTCAE


Type I Endometrial Adenocarcinoma

A classification of primary endometrial adenocarcinomas that refers to endometrioid adenocarcinoma and mucinous adenocarcinoma.


Grade 4 Carotid Artery Intra-Operative Injury, CTCAE


Stage 0 Vulvar Cancer AJCC v6

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Low Grade Endometrioid Adenocarcinoma

Endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Retention cyst

A cyst that is formed because of the blockage of the duct of a glandular organ. This results in the retention of the glandular secretions.


Grade 1 Colonic Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Hemolytic disease of fetus OR newborn due to ABO immunization

A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of anti-A or anti-B antibodies from a mother to the child via the placenta against A or B antigens of the newborn's blood.


Pancreas Exocrine Enzyme Deficiency, CTCAE


Prostate Carcinoma Metastatic in the Soft Tissue

A carcinoma that arises from the prostate gland and has spread to the soft tissues.


Grade 2 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8

Stage IIIA includes: T0-2, N1, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Hyperphosphatemia, CTCAE

Laboratory finding only and intervention not indicated


Death Not Associated with More Specific Term NOS, CTCAE


Grade 3 Wound Complication, CTCAE

Operative intervention indicated


Metastatic malignant neoplasm to viscera

A malignant neoplasm which has spread from its original site of growth to any visceral site.


Grade 2 Non-Infectious Wound Complication, CTCAE


Grade 1 Pulmonary Fibrosis, CTCAE

Radiologic pulmonary fibrosis <25% of lung volume associated with hypoxia


Tracheal Obstruction, CTCAE

A disorder characterized by blockage of the lumen of the trachea.


Cytogenetically normal acute myeloid leukemia

Acute myeloid leukemia not associated with cytogenetic abnormalities.


Adenocarcinoma in tubulovillous adenoma

A non-invasive or invasive adenocarcinoma arising from a tubulovillous adenoma.


Grade 4 Tracheal Obstruction, CTCAE

Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Orthokeratinized odontogenic cyst

An odontogenic cyst that is entirely or predominantly lined by orthokeratinized stratified squamous epithelium. (WHO 2017)


Breast Solid Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from the breast.  It is characterized by the presence of cellular solid nests and trabeculae that contain spindle-shaped, plasmacytoid, and large neuroendocrine cells.


Grade 1 Tracheostomy Site Bleeding, CTCAE

Minimal bleeding identified on clinical exam; intervention not indicated


Grade 3 Facial Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Grade 3 Skin Infection with Unknown Absolute Neutrophil Count, CTCAE


Primary Meningeal Melanocytic Neoplasm

A benign, intermediate, or malignant circumscribed or diffuse neoplasm that arises from melanocytes in the leptomeninges.  It includes meningeal melanocytoma, meningeal melanoma, meningeal melanocytoma of intermediate grade, and meningeal melanocytosis.


Lugano Classification Stage IV Hodgkin Lymphoma AJCC v8

Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the CSF, bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


Grade 3 Edema Trunk, CTCAE

Gross deviation from normal anatomic contour; limiting self care ADL


Carbon Monoxide Diffusing Capacity Decreased, CTCAE

A finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide.


Grade 4 Cranial Nerve I Neuropathy, CTCAE


Anal Inflammatory Cloacogenic Polyp

A non-neoplastic polypoid lesion that arises from the anal transitional zone.  It is characterized by the presence of hyperplastic rectal mucosa that is partially covered by squamous or transitional epithelium.


Grade 4 Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Hypoxic Ischemic Encephalopathy, AE

An hypoxic ischemic encephalopathy adverse event in a newborn which results in death.


Peritoneal and retroperitoneal disorders

A non-neoplastic or neoplastic disorder that affects the peritoneum and/or retroperitoneum.


Grade 3 Obesity, CTCAE

BMI 30-39.9 kg/m2


Recurrent Childhood Pleomorphic Xanthoastrocytoma

The reemergence of pleomorphic xanthoastrocytoma in childhood after a period of remission.


Stage IIB Cervical Cancer AJCC v8

Stage IIB includes: T2b, Any N, M0. T2b: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina with parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Life Threatening or Disabling Adverse Event

Any adverse event that places the patient, in the view of the initial reporter, at immediate risk of death from the adverse event as it occurred, i.e., it does not include an adverse experience that, had it occurred in a more severe form, might have caused death.


Single Ventricle Defect

A diverse group of congenital cardiovascular abnormalities that share one characteristic, the presence of a single functional cardiac ventricle.


Grade 4 Retroperitoneal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Non-Neoplastic Digestive System Disorder

A non-neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. Representative examples include infections, ulcers, cirrhosis, and diverticulosis.


Grade 4 Neutrophils and Granulocytes, CTCAE


Pancreas Infection, CTCAE

A disorder characterized by an infectious process involving the pancreas.


Grade 3 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Hepatitis B Reactivation, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 2 Vaginal Stenosis and Length, CTCAE


Second Primary Tumor

A new primary neoplasm that occurs in a person who was previously diagnosed with another primary neoplasm.


Infiltrating Ureter Urothelial Carcinoma with Mixed Differentiation


Metastatic non-small cell carcinoma

Non-small cell carcinoma that has spread from its original site of growth to another anatomic site.


Malignant Visual Pathway Neoplasm

A primary or metastatic malignant neoplasm that affects the visual pathway.


Grade 3 Dermatitis Radiation, CTCAE

Moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion


Grade 4 Jejunal Ulcer, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Metastatic Ampulla of Vater Carcinoma

Carcinoma that arises from the ampulla of Vater and has spread to another anatomic site.


Grade 4 Lung Thoracic Nerve Intra-Operative Injury, CTCAE


Grade 2 Cervicitis Infection, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Firearm Injury

An injury sustained by a gun.


Sternotomy Scar

Replacement of destroyed tissue by fibrous tissue due to a surgical procedure where a vertical inline incision is made along the sternum, after which the sternum itself is divided. (ACC/AHA)


Grade 5 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Outer Ear NOS Intra-Operative Injury, CTCAE


Refractory Histiocytic and Dendritic Cell Neoplasm

A histiocytic and dendritic cell neoplasm that does not respond to treatment.


Stage IIC Merkel Cell Carcinoma AJCC v7

Stage IIC includes: T4, N0, M0.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Nail Matrix Nevus

An acral nevus that arises from the nail matrix.


Myeloid Neoplasm with Mutated TP53

Myeloid neoplasm characterized by the presence of TP53 gene mutations. This category includes myelodysplastic syndrome, myelodysplastic syndrome/acute myeloid leukemia, and acute myeloid leukemia with mutated TP53.


Grade 1 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Death Due to Multi-Organ Failure Not Associated with More Specific Term, CTCAE


Lugano Classification Stage II Childhood Hodgkin Lymphoma AJCC v8

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Grade 1 Edema Face, CTCAE

Localized facial edema


Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8

Stage IVA includes: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Epilepsy congenital

A seizure disorder that is present at the time of birth.


Stage IIIA Cervical Cancer AJCC v6 and v7

Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 1 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Hematosalpinx, CTCAE

A disorder characterized by the presence of blood in a fallopian tube.


Grade 2 Leukoencephalopathy Radiographic Findings, CTCAE


Grade 3 Rash Hand or Foot Skin Reaction, CTCAE


Grade 2 Enterocolitis Infectious, CTCAE

Passage of >3 unformed stools per 24 hrs or duration of illness >48 hrs; moderate abdominal pain; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Injury to spleen with open wound into cavity

Trauma to the spleen associated with a break in the tissue that extends into the abdominal cavity.


Grade 3 Uterus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Cytomegalovirus Infection Reactivation, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated


Chemically Induced Cytotoxicity

The adverse effect of some iatrogenic therapies. It is an accepted side effect in radiation therapy where the desired effect is to kill rapidly growing tumor cells.  In the killing of tumor cells, other cells that are rapidly growing e.g hair, mucous membranes are also killed.


Grade 2 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Appendix Tubulovillous Adenoma

An adenoma arising from the appendix.  It is characterized by the presence of tubular and villous epithelial structures and it is associated with dysplasia.


Favorable Hodgkin Lymphoma

A Hodgkin lymphoma with favorable prognosis.


Unspecified dermatitis due to sun

Inflammation of the skin resulting from exposure to the sun.


Gastric Hemorrhage, CTCAE

A disorder characterized by bleeding from the gastric wall.


Hyperkalemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs.


Grade 5 Genitourinary Stoma Obstruction, CTCAE


Intraoperative Head and Neck Injury, CTCAE

A finding of damage to the head and neck during a surgical procedure.


Stage III Testicular Cancer AJCC v8

Stage III includes: Any pT/TX, Any N, M1, SX. TX: Testicular cancer in which the primary tumor cannot be assessed. M1: Testicular cancer with distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Benign Musculoskeletal Neoplasm

A mesenchymal neoplasm that arises from muscle or bone and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 2 Pelvis NOS Intra-Operative Injury, CTCAE


Grade 5 Febrile Neutropenia, CTCAE

Death


Acute Myeloid Leukemia with t(5;17)(q35;q21)

Acute myeloid leukemia with the variant RARA t(5;17)(q35;q21) and the expression of NPM1-RARA fusion protein.


Vaginal intraepithelial neoplasia grade 1

Vaginal intraepithelial neoplasia characterized by the presence of koilocytosis and disorganization and thickening of the basal layer.


Hyperpigmentation, CTCAE

An adverse reaction characterized by darkening of the skin.


Grade 1 Virilization, CTCAE

Mild symptoms; intervention not indicated


Grade 4 Hypermagnesemia, CTCAE

>8.0 mg/dL; >3.30 mmol/L; life-threatening consequences


Localized Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that is restricted to the site of origin without evidence of metastasis.


Pulmonary and Upper Respiratory Hemorrhage, CTCAE


Grade 1 Vulva Intra-Operative Injury, CTCAE


Grade 5 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Spermatic Cord Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 2 Bladder Intra-Operative Injury, CTCAE


Grade 4 Depression, CTCAE

Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Recurrent Malignant Endocervical Neoplasm

The reemergence of a malignant neoplasm of the endocervix after a period of remission.


Grade 3 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IA Gestational Trophoblastic Tumor AJCC v7

Stage IA includes: T1, M0, Risk factors: low risk.  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 4 Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Sclerodermatous Graft Versus Host Disease

A rare form of chronic graft-versus-host disease characterized by cutaneous features and/or mucocutaneous features including sclerosis, atrophy, and contractures. It may manifest as localized or generalized disease.


Chronic Myelomonocytic Leukemia-1

A chronic myelomonocytic leukemia characterized by the presence of less than 10 percent blasts in the bone marrow and less than 5 percent blasts in the peripheral blood.


Stage 0 Gallbladder Cancer AJCC v6 and v7

Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Differentiated Granulocytic Sarcoma

A granulocytic sarcoma composed of promyelocytes and more mature neutrophils (WHO 2001).


Malignant mesothelioma of the tunica vaginalis

A rare malignant mesothelioma that arises from the tunica vaginalis.


Grade 2 Testes Stricture or Stenosis, CTCAE


Grade 3 Dental-Tooth Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Burn, CTCAE

Moderate to major debridement or reconstruction indicated


Celosomy

A developmental abnormality characterized by the complex protrusion of viscera outside the abdominal wall.


Phobia, School

An overwhelming, irrational, and persistent fear of attending school.


Grade 2 Uterine Obstruction, CTCAE

Symptomatic; elective intervention indicated


Grade 5 Injury To Jugular Vein, CTCAE

Death


squamous cell carcinoma of urinary tract

A rare squamous cell carcinoma that arises from the urinary tract. Almost all cases have been reported in the bladder. Causes include urinary stasis, recurrent chronic inflammation, and smoking. In regions where schistosomiasis is endemic, it is the major etiologic factor of bladder squamous cell carcinoma.


Grade 1 International Normalized Ratio of Prothrombin Time, CTCAE


Grade 1 Cognitive Disturbance, CTCAE

Mild cognitive disability; not interfering with work/school/life performance; specialized educational services/devices not indicated


Grade 3 Tracheitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Diffuse Mixed-Cell Lymphoma

An antiquated term referring to non-Hodgkin lymphomas with a mixed cellular composition. This term applies to both B- and T- cell non-Hodgkin lymphomas.


Grade 1 GGT Increased, CTCAE

>ULN-2.5 x ULN if baseline was normal; 2.0-2.5 x baseline if baseline was abnormal


Grade 1 Muscle Weakness Left-Sided, CTCAE

Symptomatic; perceived by patient but not evident on physical exam


Grade 3 Catheter Related Infection, CTCAE


Grade 3 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 4 Pancreatic Endocrine Glucose Intolerance, CTCAE


Agonizing Pain

A sensation of great anguish and suffering.


Recurrent Cervical Squamous Cell Carcinoma

The reemergence of cervical squamous cell carcinoma after a period of remission.


Intrahepatic Bile Duct Microcystic Adenoma

An adenoma that arises from the intrahepatic bile ducts and it is characterized by the presence of microcystic changes.


Grade 3 Cervical Spine Range of Motion, CTCAE


Refractory WHO Grade 3 Glioma

A WHO grade 3 glioma that is resistant to treatment.


Non-Hematologic Malignancy

A malignant neoplasm that arises from a site other than the bone marrow and lymphoid tissue.


Metastatic Micropapillary Urothelial Carcinoma

Micropapillary urothelial carcinoma that has spread to another anatomic site.


Pathologic Stage II Cutaneous Melanoma AJCC v8

Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Stage IC Fallopian Tube Cancer AJCC v8

Stage IC includes: T1c, N0, M0. T1c: Fallopian tube cancer with tumor limited to fallopian tubes, with any of the following: surgical spill, capsule ruptured before surgery or tumor on fallopian tube surface, or malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Metastatic gastric adenocarcinoma

A gastric adenocarcinoma that has spread from its original site of growth to another anatomic site.


Endometrial Endometrioid Adenocarcinoma with Small Glands, Tubules or Cords


Unresectable Vulvar Carcinoma

Vulvar carcinoma that is not amenable to surgical resection.


Grade 3 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Stage I Gastric Cancer AJCC v6

Stage I includes: IA: (T1, N0, M0) and IB: (T1, N1, M0); (Ta/b, N0, M0).  T1: Tumor invades lamina propria or submucosa.  T2: Tumor invades the muscularis propria or the subserosa.  T2a: Tumor invades muscularis propria. T2b: Tumor invades subserosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1 to 6 regional lymph nodes.  N2: Metastasis in 7 to 15 regional lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.)


Dysesthesia, CTCAE

A disorder characterized by distortion of sensory perception, resulting in an abnormal and unpleasant sensation.


Esophageal Mass

An abnormal growth located in the esophagus.


Grade 4 Spinal Cord Intra-Operative Injury, CTCAE


Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage I Ampulla of Vater Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor measuring 1 cm or less and is confined within the sphincter of Oddi. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Neuronevus

An intradermal nevus characterized by the presence of nests of atrophic nevus cells which are hyalinized and resemble nerve bundles.


Superior Vena Cava Syndrome, CTCAE

A disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache.


Late effect of radiation

Late radiation injury (LRI) is the damage to the soft tissue and bone following radiation therapy that occurs weeks and years after the radiation exposure. Pathogenesis of LRI stems from ischemia, interruption of the blood supply and direct cell damage. LRIs include but not limited to the skin atrophy, ulceration and non-healing wounds; cystitis, proctosigmoiditis, resulting to fistulas, abscesses, fibrosis and scaring; laryngitis, osteoradionecrosis; central nervous system injury, optic neuropathy.


MGMT-Unmethylated Glioblastoma

A glioblastoma characterized by the absence of DNA methylation in the promoter region of the MGMT gene. It is associated with a poor outcome.


Shunt thrombosis

The presence of a thrombus within a vascular shunt.


Grade 3 Thrombotic Thrombocytopenic Purpura, CTCAE

Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae)


Benign Peritoneal and Retroperitoneal Neoplasm

A neoplasm that arises from the peritoneum and/or retroperitoneum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 4 Ileus, CTCAE

Life-threatening consequences; urgent intervention indicated


Metastatic Large Cell Neuroendocrine Carcinoma

A large cell neuroendocrine carcinoma that has metastasized from its original site of growth to another anatomic site.


Localized Childhood Astrocytoma by Toronto Guidelines v2

Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIIA Bladder Cancer AJCC v8

Stage IIIA includes: (T3a, T3b, T4a, N0, M0); (T1-T4a, N1, M0). T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T3a: Tumor invades perivesical soft tissue, microscopically. T3b: Tumor invades perivesical soft tissue, macroscopically (extravesical mass). T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node). M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Lymphocyte Count Increased, CTCAE


Moderate Grade Fever

Body temperature ranging between 102.1 degrees Fahrenheit (39 degrees Celsius) and 103.9 degrees Fahrenheit (39.9 degrees Celsius).


Agoraphobia without history of panic disorder

An anxiety disorder characterized by agoraphobia in the absence of a history of panic attacks; the individual fears incapacitation or humiliation in open, public places or situations due to panic-like symptoms rather than a full-blown panic attack.