Normal Virilization

The normal development of male secondary sexual characteristics (such as hirsutism, deepening of the voice) in pubertal boys due to testosterone effects.


Insulin Coma

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A hypoglycemia-induced comatose state resulting from a large dose of exogenous insulin.


Adult Third Ventricle Colloid Cyst

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Large Pleural Effusion

A pleural effusion that is typically characterized as more than one liter.


Paroxysmal Supraventricular Tachycardia by ECG Finding

An electrocardiographic finding of episodic supraventricular tachycardia with abrupt onset and termination.


Pregnancy Outcome

Findings observed at the end of a pregnancy.


Maximum ST Segment Depression by ECG Finding

An electrocardiographic finding of the maximum depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Dichorionic Diamniotic Twin Pregnancy

A pregnancy involving two fetuses that each have separate chorions and amniotic sacs.


Jejunal Stenosis

Narrowing of the lumen of jejunum.


Hypotension due to Cardiac Dysfunction

A condition in which there is hypotension because of inadequate pumping function of the heart. (ACC/AHA)


Right Ventricular Hypertrophy by ECG Finding

An electrocardiographic finding suggestive of a hypertrophied right ventricle, characterized by large R wave amplitudes in the right precordial leads and secondary findings of right atrial enlargement, right axis deviation, and typical pattern of ST depression and T wave inversion in the right precordial leads. (CDISC)


Intestinal Stoma Obstruction

A blockage of the intestinal stoma.


Lightheadedness

A feeling of faintness; a reeling sensation. Lightheadedness is medically distinct from dizziness, unsteadiness, and vertigo.


Cyst of thyroid

Abnormal fluid filled sac within the thyroid gland.


Secondary pulmonary hypertension

Pulmonary hypertension that is caused by an underlying condition.


Reproductive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the reproductive system.


Vaginal Perforation

A rupture in the vaginal wall due to traumatic or pathologic processes.


Intraoperative Arterial Injury

Damage to an artery during a surgical procedure.


Pregnancy Status

The pregnancy status of an individual.


High Grade Atrioventricular Block by ECG Finding

An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by two or more consecutive non-conducted P waves. (CDISC)


Ureter Compression

Narrowing of the luminal diameter of one or both ureters due to extrinsic pressure.


COVID-19-Associated Acute Liver Injury

Acute liver injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Foreign body in esophagus

Extraneous material located within the esophagus.


Postpartum Mental or Behavioral Disorder

A maternal mental or behavioral disorder that occurs in the period following the birth of a child and extending up to six weeks after delivery.


Hyperreninemic hypoaldosteronism

Hypoaldosteronism characterized by impaired secretion of aldosterone, despite increased renin activity. This condition may be caused by chronic or critical illness, aldosterone synthase deficiency or other genetic conditions.


Immunodeficiency due to Functional Defects

An indication that an immunodeficiency disorder is caused by the presence of immune cells that are dysfunctional.


Moderate Hepatic Insufficiency

Findings indicating moderate impairment of liver function.


Chronic Maternal Hypertension with Superimposed Preeclampsia

Chronic hypertension in association with preeclampsia.


Reproductive System Hemorrhage

Bleeding originating in the organs and tissue that aid in reproduction.


Monochorionic Monoamniotic Twin Pregnancy

A pregnancy involving two fetuses that share both the chorion and amniotic sac. These twins are invariably identical.


Cardiovascular injury

Trauma to the heart and/or blood vessels.


Urostomy Obstruction

Blockage of the urostomy.


Esophageal injury

Trauma to the esophagus.


Extreme Preterm Birth

Birth when a fetus is less than 28 weeks gestational age.


Female Virilization

The development of male secondary sexual characteristics (such as hirsutism, deepening of the voice, or clitoral enlargement) in girls or adult females.


Vaginal obstruction

Congenital or acquired blockage of the vagina.


Anterior segment ischemia

Compromise of blood supply to the anterior segment of the eye.


Esophageal Anastomotic Leakage

Leakage due to breakdown of an esophageal anastomosis.


Burn of esophagus

Thermal or caustic injury to the esophagus.


Spinal Meningeal Cyst

A cerebrospinal fluid-filled pouch or sac-like protrusion of the arachnoid, dura mater, or nerve root sheath which may contain neural tissue.


Oversedated

A level of sedation that is greater than the intended level.


Eye and Ear Finding

Symptoms, physical examination results, and/or laboratory test results related to the organs of special sense.


Intrapartum Stillbirth

Fetal death greater than or equal to 20 weeks of gestation during labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond.


Visual Halo

Hazy ring around bright lights seen by some patients with refractive error or optical defects, e.g. cataracts, or corneal swelling.


Injury of conjunctiva

Trauma to the conjunctiva of the eye.


Elective Abortion Finding

An abortion performed due to individual choice, in the absence of a harmful medical condition caused by pregnancy.


Leg Injuries

Trauma to the lower extremity, which is confined to the area between the hip and ankle joints.


Fetal Heart Finding

An observation of the fetal heart that may or may not be abnormal.


Urethral cyst

A cystic lesion located in the urethra.


Pulmonary vein obstruction

Blockage of the lumen of the pulmonary vein.


Testosterone Excess

Abnormally high level of testosterone.


Ureteric Perforation

A rupture in the wall of the ureter due to traumatic or pathologic processes.


Minimum ST Segment Depression by ECG Finding

An electrocardiographic finding of the minimum depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Urinary System Finding

Symptoms, physical examination results, and/or laboratory test results related to the urinary system.


Reperfusion Injury

Tissue damage caused when blood supply returns to tissue after a period of ischemia or lack of oxygen. The restoration of circulation results in inflammation and oxidative damage.


Cardiogenic Shock Stage D Related to COVID-19

Clinical signs of deteriorating cardiogenic shock in a patient with probable or confirmed acute COVID-19. Failure to respond to initial interventions to restore adequate perfusion after 30 minutes. Further more intensive therapies are required, including the addition of mechanical circulatory support.


Undesired Nerve Stimulation

Unintended reaction in nervous system caused by electrical stimulation.


Carotenosis Cutis

Orange or yellow discoloration of the skin caused by excessive deposits of carotene.


Anticipatory Vomiting

A situation in which an individual vomits prior to a medical treatment, commonly chemotherapy, as part of a conditioned/learned response after having previously experienced nausea and/or vomiting as a direct result of that same (or a similar) treatment.


Pulmonary Artery Wedge Pressure

The pressure measured by wedging a pulmonary catheter with an inflated balloon into a small pulmonary arterial branch.


COVID-19-Associated Acute Gastrointestinal Tract Injury

Acute gastrointestinal tract injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Enhanced Tendon Reflex

Greater than normal deep tendon reflexes.


Visceral Artery Ischemia

Decreased blood supply to the small or large intestine due to narrowing or blockage of a visceral (mesenteric) artery. The ischemia results to the damage of the intestinal tissues. It may be chronic, caused by atherosclerosis or acute, secondary to the formation of a thrombus or embolus in the mesenteric arterial lumen. In chronic ischemia, patients present with abdominal pain manifested in a short time after a meal and weight loss. In acute ischemia, patients present with sudden and acute abdominal pain, nausea and vomiting, and blood in the stool.


Obstruction of colon

Blockage of the normal flow of the intestinal contents in the colon.


Caries Restricted to Enamel

Tooth decay that is restricted to the enamel layer.


Adrenal Cyst

A cyst located in the adrenal gland.


Duodenal hemorrhage

Bleeding originating from the duodenum.


Congenital Neurogenic Bladder

Neurogenic bladder, the cause of which is present at birth.


AV Block Second Degree by ECG Finding

An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles. This is manifest on the ECG by regular P waves which intermittently are not followed by QRS complexes. (CDISC)


Borderline hypertension

Blood pressure in the zone between the highest normal level and the level that is considered hypertensive.


Jacksonian Seizure

A partial motor seizure that begins in a single area of the body and progresses to include other areas on the same side of the body.


Oculocardiac Reflex

Slowing or cessation of the heart rate secondary to traction on the extraocular muscle.


Intraoperative cardiac valve injury

An intraoperative event that causes abnormal valve function; this is usually a tear in the leaflet or the chordae tendinae.


Rheumatic tricuspid valve stenosis

Tricuspid valve stenosis secondary to rheumatic fever.


Cardiogenic Shock with Distributive Shock Related to COVID-19


Intervertebral Disc Compression or Protrusion

Degenerative, pathological or traumatic changes in the cartilaginous tissue of the spine leading to unwanted compression or protrusion of the disc.


Ventricular Arrhythmia by ECG Finding

An electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles.


Ear Finding

Symptoms, physical examination results, and/or laboratory test results related to the ear.


Coronary Artery Aneurysm Related to COVID-19

Coronary artery aneurysm in a patient with probable or confirmed acute COVID-19.


Alterations in Smell or Taste

A change to taste and/or olfactory perception resulting from disease processes or treatment.


Non-Febrile Seizure

A seizure that is not associated with fever.


Jugular vein injury

Damage to the jugular vein from traumatic or pathologic processes.


Psychosexual dysfunction with inhibited sexual excitement

Recurrent and persistent suppression of sexual excitement during sexual activity.


Impaired Balance

A deficit in equilibrium, which may manifest as unsteady ambulation or inability to maintain an upright position.


Decreased Physical Activity

A reduction in the normal physical activity for an individual.


Gastrointestinal Stoma Stenosis

Narrowing of the lumen of a gastrointestinal stoma.


Cecal Hemorrhage

Bleeding originating in the cecum.


Mean ST Segment Depression by ECG Finding

An electrocardiographic finding of the average depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Arrhythmogenic Syncope

A condition in which syncope occurs due to an arrhythmia. (ACC/AHA)


Melanocortin Pathway Defect

An abnormality in the biochemical pathway involving the melanocortins, a group of peptide hormones associated with anorexogenic signaling in the brain and hypothalamus.


Delayed Orgasm

Sexual dysfunction characterized by a delay in climax.


Intraoperative Ear Injury

Damage to the ear during a surgical procedure.


Endocrine System Signs and Symptoms

Patient complaints, physical findings, laboratory findings referable to the endocrinologic system.


Therapeutic Abortion Finding

An abortion performed on the individual due to a harmful medical condition caused by pregnancy.


Drug-induced hypotension

A condition in which there is hypotension because of the effects of a medication or other substance. (ACC/AHA)


Micropsia

An alteration in visual perception that causes objects to appear smaller than their actual size.


Hormone Imbalance

An abnormal finding indicating that the level of a particular hormone is not within the expected normal values.


Syncope due to Congenital Heart Lesion

A condition in which syncope occurs due to a disease process of the heart with which the patient was born. (ACC/AHA)


Rheumatic mitral stenosis

Mitral valve stenosis secondary to rheumatic fever.


Headache due to external compression of head

Headache resulting from pressure applied to the cutaneous nerves of the head.


Acoustic Trauma

Injury to the hearing mechanisms within the inner ear, caused by excessively loud noise.


Cyst of pharynx

A cervical cyst that occurs as a result of the persistence of one or more of the pharyngeal grooves.


Intraoperative Renal Injury

Damage to the kidney during a surgical procedure.


Perforation of great vessels

Damage to the venae cavae, pulmonary artery, pulmonary veins or aorta resulting from a full thickness disruption in the integrity of the vessel wall.


Congenital isolated adrenocorticotropic hormone deficiency

Adrenocorticotropic hormone (ACTH) deficiency due to mutation(s) in the TBX19 gene.


Malignant Bowel Obstruction

Obstruction of the bowel by an advanced malignant tumor. It is a complication especially in patients with an advanced abdominal malignant tumor.


Ileal hemorrhage

Bleeding originating from the ileal wall.


Pneumopericardium

The presence of air in the pericardial cavity. Causes include chest injury in adults, and respiratory distress syndrome in infants.


Intraoperative Cardiac Injury

Damage to the heart during a surgical procedure.


Embolus

A mass of clotted blood or other formed elements, such as bubbles of air, calcium fragments, etc. brought by the blood from another vessel and forced into a smaller one, thus obstructing the circulation.


Incomplete Bundle Branch Block by ECG Finding

An electrocardiographic finding of partially blocked cardiac electrical impulse conduction along the fibers of one or both bundle branches.


Visual Disturbance

An interference to normal eyesight.


Umbilical Cord Finding

Clinical and laboratory findings about the umbilical cord.


Aldosterone Synthase Deficiency

An autosomal recessive condition due to mutation(s) in the CYP11B2 gene that results in decreased activity of mitochondrial cytochrome P450 11B2 with reduced aldosterone synthesis and salt wasting.


First Trimester Antepartum Hemorrhage

Excessive blood loss within the first trimester but prior to onset of labor.


Injury of liver with open wound into abdominal cavity

Trauma to the liver associated with a break in the tissue that extends into the abdominal cavity.


Aneurysm, Bacterial

An aneurysm caused by an infection.


Endometrioma

A cystic form of endometriosis affecting the ovary.  It may or may not be associated with endometriosis in other areas in the pelvis.


Lamellar laceration of the globe

Traumatic injury to the globe, resulting in a partial thickness wound of the eyewall (cornea and/or sclera). (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Acute Liver Injury with Fulminant Failure Related to COVID-19

Acute liver injury manifested by rapid loss of liver function associated with abnormal liver enzyme levels, coagulopathy or encephalopathy, and often multiorgan failure in a patient with probable or confirmed acute COVID-19.


Cerebrospinal Fluid Otorrhea

Discharge of cerebrospinal fluid through the ear structures.


In-Hospital Cardiac Arrest

Cardiac arrest which occurs in the hospital setting.


Knee Injuries

Trauma to the knee.


Malignant Effusion

An accumulation of fluid that contains floating individual or groups of malignant cells in a body cavity. It results from either the development of a primary malignant neoplasm in the lining of the cavity or spread of a malignant neoplasm in the cavity from another site.


Elbow Injuries

Trauma to the elbow joint.


Intracranial Colloid Cyst

Colloid cysts i.e. cysts filled with gelatinous material, in the central nervous system often are found in the third ventricle. Due to their location, chronic or intermittent hydrocephalus can result. Case reports of sudden death due to acute obstructive hydrocephalus are in the literature. Colloid cysts are benign lesions that should be considered for neurosurgical resection.


Acquired Neurogenic Bladder

Neurogenic bladder, the cause of which is not present at birth.


Migraine-triggered seizure

A seizure triggered by a migraine.


Musculoskeletal Finding

Symptoms, physical examination results, and/or laboratory rest results related to the muscles and bones.


Monochorionic Diamniotic Twin Pregnancy

A pregnancy involving two fetuses that share the same chorion but have separate amniotic sacs.


Kidney perforation

A rupture in the kidney due to traumatic or pathologic processes.


Decreased Uncorrected Visual Acuity

Diminished clarity of vision without optical correction (glasses and/or contacts).


Cardiac Arrest/Arrhythmia Etiology Unknown

An episode of cardiac arrest or arrhythmia where the etiology was unknown. (ACC)


Acquired Urinary Tract Obstruction

A urinary tract obstruction, the cause of which is not present at birth.


Adrenal Androgen Excess

Excessive secretion of the androgen hormones dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione, from the adrenal gland. Clinical manifestations may include virilization.


Cardiogenic Shock Stage E Related to COVID-19

Clinical signs of extremis in a patient with cardiogenic shock and probable or confirmed acute COVID-19. Highly unstable, often with circulatory collapse and/or refractory cardiac arrest with ongoing cardiopulmonary resuscitation (CPR). They are being supported by multiple simultaneous acute interventions including extracorporeal membrane oxygenation (ECMO)-facilitated CPR (eCPR).


Complicated Parapneumonic Pleural Effusion

An accumulation of fluid in the pleural space adjacent to an infectious pulmonary process, such as a pneumonia or a lung abscess, and that requires therapeutic drainage.


Mitral perforation

A rupture in the mitral valve tissue due to traumatic or pathologic processes.


Male Reproductive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the male reproductive system.


Injury of esophagus without open wound into thoracic cavity

Trauma to the esophagus without indication of associated damage to the skin and other internal and external tissues.


Hemorrhage of prostate

Bleeding originating from the prostate gland.


Fallopian tube perforation

A rupture of the fallopian tube wall due to tubal pregnancy, or other traumatic or pathologic processes.


Postpartum Complication

Any adverse event that arises in the six week period immediately following the delivery of a fetus.


Fetal virilism

Inappropriate secondary sex characteristics in the neonate usually due to in utero androgen exposure.


Subclinical Seizure

A seizure with no apparent symptoms.


Pathologic Laughter

A condition defined by relatively uncontrollable episodes of laughing.


Injury of larynx

Trauma to the larynx.


Injury of anus

Trauma to the anus.


Syphilitic aneurysm of aorta

Aneurysm of the aorta secondary to syphilis.


Early Pregnancy Loss

Pregnancy loss before 10th week of gestation with documentation of a confirmed pregnancy.


Endocrine System Finding

Symptoms, physical examination results, and/or laboratory test results related to the endocrine system.


Laceration of the Globe

Full-thickness wound of the eyewall (cornea and/or sclera) caused by a sharp object.


Foreign body in stomach

Extraneous material located within the stomach.


Arteriovenous fistula aneurysm

A bulge in a weakened vessel wall segment of an arteriovenous fistula.


Insulin Shock

A hypoglycemic reaction to overdosage of insulin, a skipped meal, or strenuous exercise in an insulin-dependent diabetic.


Coma Greater than 24 Hours

An indication that coma has lasted more than 24 hours.


Proximal Left Anterior Descending Coronary Artery Stenosis

A narrowing of the proximal portion of the left main coronary artery, usually considered significant if the stenosis is 70% or greater.


Tearing

Shedding of tears.


Fine corneal edema

Corneal edema of inflammatory origin associated with contact lens wear and morphologically characterized by presence of epithelial microcysts. Microcysts are small (typically 10-50 microns in diameter), clear, irregularly shaped high refractive inclusions that form in the basal layers of the epithelium and move towards the anterior surface of the cornea, surrounding epithelial haze. The cause of microcytic edema is related to the physical presence of contact lenses and possibly a mechanical effect of lens wear.


Penetrating open globe injury

Full thickness wound of the eyewall (cornea and/or sclera) caused by the entry of a sharp object into the eye. (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Achalasia

Failure of the smooth muscle fibers of the gastrointestinal tract to relax at any one point of junction of one part with another.


Macropsia

An alteration in visual perception that causes objects to appear larger than their actual size.


Erythema of the Oropharyngeal Mucosa

Erythema of the mucus membranes lining the part of the pharynx located between the soft palate and the upper portion of the epiglottis.


Tracheostomy Site Bleeding

Bleeding from the tracheostomy site.


left main coronary artery stenosis

Percent luminal narrowing of the left main coronary artery, at the point of maximal stenosis of the left main coronary artery.


Eye muscle weakness

A reduction in the strength of the eye muscles.


Urinary Tract Stenosis

An intrinsic narrowing of a lumen of the urinary tract.


Sensory Change

An alteration in the perceptual senses an individual.


Ileal Obstruction

Blockage of the normal flow of the small intestinal contents in the ileum.


Ventricular Tachycardia/Ventricular Fibrillation Arrest

A cardiac arrest attributed to ventricular tachycardia or ventricular fibrillation.


AV Block Second Degree Mobitz Type I by ECG Finding

An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a progressively lengthening PR interval prior to the block of an atrial impulse. (CDISC)


Familial Male Precocious Puberty

Early development of isosexual secondary characteristics in boys, due to autosomal dominant mutations in the LHCGR gene.


Pigmentary Change in Skin

Abnormal skin pigmentation.


Injury to Superior Vena Cava

Damage to the superior vena cava from traumatic or pathologic processes.


Refractory Esophageal Anastomotic Stricture

Esophageal anastomotic stricture that remains narrowed despite repeated therapeutic dilations.


Antepartum Uterine Rupture

An acute symptomatic tearing of the uterine wall prior to the onset of labor.


Carotid Artery Injuries

Damage to the carotid artery. Causes include blunt injuries (e.g., motor vehicle accidents and sports-related injuries) and penetrating traumas (e.g., gunshot and knife injuries).


Dissecting Abdominal Aortic Aneurysm

A dissecting aneurysm in the portion of the descending aortic wall that is within the abdomen.


Chronic peritoneal effusion (disorder)

Persistent or recurring accumulation of fluid in the peritoneal cavity.


Vaginal Discharge

Normal or abnormal secretions from the vagina. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Causes of abnormal vaginal discharge include infectious agents (e.g., Neisseria gonorrhea, Chlamydia trachomatis, Trichomonas, and Candida albicans), the presence of foreign bodies, and cervical or vaginal cancer.


Erb-Duchenne Paralysis

Weakness or paralysis of muscles in the arm due to damage in the upper brachial plexus.


Spontaneous Intestinal Perforation

A focal intestinal perforation without a definite cause, commonly located in the terminal ileum, lacking the transmural inflammation and/or pneumatosis typically seen in necrotizing enterocolitis.


Cardioinhibitory Syncope

A condition in which neurally-mediated syncope occurs in which the blood pressure falls and heart rate falls. (ACC/AHA)


Nail Changes

Alteration of the normal characteristics of the fingernails or toenails. Examples include thickening, thinning, deformity, and separation from the nail bed.


Zenker Diverticulum

A diverticulum of the posterior pharyngeal wall opening, which is located just posterior the cricoid cartilage, between the inferior pharyngeal constrictor and the cricopharyngeus muscles.


Visual Change

An alteration in the visual system of an individual.


Foot Or Leg Hypoesthesia

Consisting of abnormally decreased sensitivity, particularly to touch in the foot or leg.


Hormone Resistance

A finding indicating decreased tissue sensitivity to a hormone.


Finger Injuries

Trauma to one of the digits on the hand.


Gastrointestinal Adhesion

A fibrous connection of tissue that joins together normally separate gastrointestinal regions.


Urostomy perforation

A perforation in the anatomic parts which are used in the construction of a urostomy.


Heart Block by ECG Finding

An electrocardiographic finding of blocked cardiac electrical impulses along the fibers normally responsible for impulse conduction.


Unilateral Numbness

A loss of the sensation of feeling on one side of the body.


Perforating open globe injury

Open globe injury with both entrance and exit wounds in the eyewall (cornea and/or sclera) caused by the same object.


Cushing Triad

A group of signs that often occurs in response to increased intracranial pressure: hypertension, bradycardia, and irregular breathing.


Flasher

The perception of sudden or brief bursts (flashes) of light.


Acquired Adrenocorticotropic Hormone Deficiency

Adrenocorticotropic hormone (ACTH) deficiency, the cause of which is not present at birth.


Hemorrhage of digestive system

Bleeding originating from any part of the digestive system.


Recurrent Esophageal Anastomotic Stricture

Recurrence of an esophageal anastomotic stricture following therapeutic dilation.


Syncope due to Migraine

A condition in which syncope occurs associated with the occurrence of cerebral vasospasm. (ACC/AHA)


Caries, Region Unknown

Tooth decay of an unspecified location.


Cardiogenic Shock Stage B Related to COVID-19

Clinical signs of shock or compensated shock in a patient with probable or confirmed acute COVID-19 wherein they may be volume overloaded, tachycardic, and/or hypotensive but no evidence of hypoperfusion on physical exam or laboratory studies.


Vasoconstriction

Vasoconstriction involves narrowing of a blood vessel lumen due to smooth muscle contraction in the vessel wall and leads to decreased blood flow.


Connective and Soft Tissue Injury

Damage inflicted on the soft tissues and their supporting structures as the direct or indirect result of an external force, with or without disruption of structural continuity.


Motor Manifestations

The presence of an alteration in the ability to move one's body or any body parts in accordance with one's intent.


Stricture of ureter

Narrowing of the lumen of the ureter.


Ureterovesical Obstruction

Blockage of the opening between the ureter and the bladder resulting in the reduction or prevention of the urine flow from the ureter to the bladder.


Supraventricular Arrhythmia by ECG Finding

An electrocardiographic finding of an arrhythmia originating in the atrium, AV node or AV junction.


Electrocardiographic Finding

Graphic representation and categorization of the electrical vectors produced by the depolarization and repolarization of myocardial tissue.


Unspecified antepartum hypertension

High blood pressure in the period of time preceding labor and delivery.


Primary Cough Headache

Headache triggered by coughing or straining in the absence of an intracranial disorder.


Seizure Related to COVID-19

Seizure in a patient with probable or confirmed acute COVID-19.


Bronchial Stricture

Narrowing of a bronchial tube.


Digestive System Signs and Symptoms

Signs and symptoms associated with disturbances within the digestive system, which includes the stomach, intestines and all associated organs that aid in digestion.


Intestinal Stoma Site Hemorrhage

A finding of blood leakage from the intestinal stoma.


Vaginal Cyst

A cyst located in the vagina.


Cardiogenic Shock Stage C Related to COVID-19

Clinical signs of cardiogenic shock with clinical evidence of hypotension and hypoperfusion (cold and wet) on physical examination that requires intervention (inotrope, pressor or mechanical support, including extracorporeal membrane oxygenation (ECMO)) beyond volume resuscitation to restore normal perfusion in a patient with probable or confirmed acute COVID-19.  Invasive hemodynamics may demonstrate the classic depressed cardiac index associated with cardiogenic shock.


Conjunctival Ecchymosis

Bleeding between the conjunctiva and episclera in the absence of discharge or inflammation.


Jejunal hemorrhage

Bleeding originating from the jejunal wall.


Recurrent Large Pleural Effusion

The reemergence of a large pleural effusion after a period of remission.


Uncomplicated hypertension

A condition of high blood pressure without resulting clinical disorders.


Vascular stenosis

Narrowing of the lumen of an artery or vein.


Delayed Nausea and Vomiting

Nausea and vomiting occurring more than 24 hours following chemotherapy.


Cervical Spine Joint Range of Motion Decreased

Decreased flexibility of a cervical spine joint.


Phosphene Visualization

An objective visual sensation that appears with the eyes closed and in the absence of visual light.


Testicular Cyst

A cystic lesion located in the testes.


Valvular stenosis

Narrowing of the opening of one or more of the four valves of the heart.


Inferior vena cava stenosis

Abnormal narrowing of the lumen of the inferior vena cava.


Page kidney

Hypertension resulting from activation of the renin-angiotensin system in response to prolonged compression of the renal parenchyma and blood vessels.


Decreased Visual Acuity with Current Correction

Diminished clarity of vision with current correction (glasses and/or contacts).


Congenital obstruction of ureteropelvic junction

Complete or partial blockage of the ureter at the point where it enters the kidney that is present at birth.


Phantogeusia

A lingering, usually unpleasant, taste without the associated stimulus.


Vas deferens stenosis

Narrowing of the lumen of the vas deferens.


Breastfeeding Jaundice

Yellow coloring of skin, mucous membranes and eyes in an otherwise healthy breast-fed newborn due to insufficient intake of maternally-expressed milk. It commonly appears four to seven days after birth.


Carcinomatous ascites

Accumulation of fluid in the peritoneal cavity resulting from the growth of primary or metastatic carcinoma in the peritoneum.


Neck sprain

Stretching or tearing of ligaments in the neck.


Radiation-induced stricture of esophagus


Laceration of liver

A cut or tear in the liver.


Incomplete Left Bundle Branch Block by ECG Finding

An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the left ventricle, manifest as a widened initial portion of the QRS complex in leads V5, V6, I and aVL and with QRS duration less than 120 ms. (CDISC)


Left Main Coronary Artery Stenosis, Percentage

The percentage of narrowing of the left main coronary artery.


Extraocular Muscle Paresis

A slight or incomplete paralysis of an extraocular muscle.


Laryngeal Hemorrhage

Bleeding originating from the larynx.


Loss of Vision

A condition in which the ability to see is impaired.


Open globe injury

A full thickness wound of the eyewall (sclera and cornea). (Birmingham Eye Trauma Terminology System (BETTS))


Primary Exertional Headache

Headache triggered by exercise.


Pregnancy Related Skin Change

Alterations in the skin's appearance during pregnancy due to hormonal level changes.


Numbness

A loss of the sensation of feeling in an area of the body.


Decreased Sperm Count

A finding indicating the presence of a lower than expected number of spermatozoa in the semen.


Active Caries

Tooth decay that is increasing in size or scope.


Hemorrhagic ascites

Accumulation of hemorrhagic fluid in the peritoneal cavity.


Late Fetal Death

Death of a fetus at 16 weeks, 0 days to 19 weeks, 6 days of gestation.


Hemorrhage of spermatic cord

Bleeding originating from the spermatic cord.


Chemical burns of eye

Injury to the eye secondary to a chemical substance.


Diastolic hypertension

Hypertension characterized diastolic blood pressure greater than 90 mmHg on two occasions.


Sternocleidomastoid Injury Related to Birth

Disruption of the sternocleidomastoid muscle incurred during delivery.


Aldosterone Synthase Deficiency Type 1

Aldosterone synthase deficiency characterized by decreased conversion of corticosterone to 18-hydroxycorticosterone.


Vas deferens obstruction

Blockage of the normal flow of the sperm in the vas deferens.


Bowel Burn

A thermal, chemical or radiation injury to the bowels.


injury of rectum with open wound into cavity

Trauma to the rectum associated with a break in the tissue that extends into the rectum.


Ligament injury

An injury to any of the fibrous bands of tissue that comprise an articulation (joint).


Brachial Plexus Palsy

An injury that results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm. In the majority of cases there is spontaneous recovery.


Bone injury

Trauma to bone.


Endoleak

Persistent blood flow/pressure in the aneurysm sac following an endovascular aneurysm repair (EVAR) procedure.


Blacking Out

A temporary loss of consciousness or a temporary state of altered consciousness that results in memory loss.


Bradycardia Arrest

Cardiac arrest that was a result of bradycardia.


Connective and Soft Tissue Finding

Symptoms, physical examination results, and/or laboratory test results related to the connective and soft tissue.


Fetal Hypoxemia

Abnormally low arterial blood oxygen concentration in a fetus.


Muscular Tic

An involuntary, compulsive, repetitive stereotyped movement, usually of the face or shoulders.


Unspecified renovascular hypertension

High blood pressure caused by renal artery stenosis.


Nervous System Finding

Symptoms, physical examination results, and/or laboratory test results related to the nervous system.


Early Fetal Death

Death of a fetus at 10 weeks, 0 days to 15 weeks, 6 days of gestation.


Neurogenic Orthostatic Hypotension

Orthostatic hypotension due to autonomic dysfunction. Primary neurogenic orthostatic hypotension (nOH) may be associated with disorders such as Parkinson disease (PD) and multiple system atrophy (MSA) whereas secondary nOH may be seen in peripheral neuropathies.


Delayed Postpartum Hemorrhage

Excessive blood loss between 24 hours after delivery through four weeks that requires intervention.


Tingling

A sensation as of repetitive pin pricks, caused by cold or by striking a nerve, or as a result of various diseases of the central or peripheral nervous system.


Abnormal Sensation of Face and Limbs

Sensations of the face and limbs that are not considered normal.


Small Intestinal Anastomotic Leakage

Leakage due to breakdown of a small intestinal anastomosis.


Chronic Maternal Hypertension

Hypertension that predates pregnancy.


Junctional premature complex (disorder)

An electrocardiographic finding of an ectopic impulse originating in the AV junction presenting as a QRS complex of supraventricular origin which is not preceded by a P wave. (CDISC)


Immunodeficiency due to Quantitative Defects

An indication that an immunodeficiency disorder is caused by a partial or complete loss of one or more of the hematopoietic cell lineages that are involved in host defense.


Injury of duodenum with open wound into abdominal cavity

Trauma to the duodenum associated with a break in the tissue that extends into the abdominal cavity.


Drug-induced Syncope

A condition in which syncope occurs due to the ingestion or administration of a chemical substance. (ACC/AHA)


Fetal Presentation

The first part of the fetus that is visible at the cervical opening during delivery.


Hand Injuries

Trauma to the hand.


Bursa injury

Trauma to a bursa.


Abnormal Gait and Coordination

Gait and coordination movements that are not considered normal.


Postoperative Hypertension

A transient increase in blood pressure following a surgical procedure.


Fecal Occult Blood

Blood in the feces that is not visibly apparent.


Endobronchial Obstruction

Partial or complete blockage of the bronchial lumen by a pathological process that occurs within the bronchus.


Mottling

Irregularly shaped, patchy discolorations in the skin.


Third Trimester Antepartum Hemorrhage

Excessive blood loss within the third trimester but prior to onset of labor.


Iris pigment epithelial cyst

A cystic lesion arising from the iris pigment epithelium at the posterior iris surface. (WHO 2018)


Abortion complete

Expulsion of all the products of conception following spontaneous, medical or operative pregnancy termination.


Induced Abortion Finding

Abortion brought on intentionally.


Corneal burn

Chemical or radiant injury to the cornea.


Arteriovenous graft aneurysm

A bulge in a weakened wall segment of an arteriovenous graft.


Spermatic cord obstruction

Blockage of the normal flow of the contents of the spermatic cord.


Systolic Hypertension

Abnormally high systolic blood pressure.


Hematosalpinx

The presence of blood in a fallopian tube.


Associated Pulmonary Arterial Hypertension

Pulmonary hypertension that results from another disorder (e.g., connective tissue disorder).


ST Segment Abnormality by ECG Finding

An electrocardiographic finding of ST segment elevation or depression.


Ovarian Hyperandrogenism

Increased production of androgens by the ovaries.


Exit Block by ECG Finding

An electrocardiographic finding in which impaired conduction or automaticity within the sinus node results in the failure of impulse transmission from the sinoatrial node. This is manifested as dropped P waves during sinus rhythm. (CDISC)


Intraoperative Venous Injury

Damage to a vein during a surgical procedure.


Severe Cardiac Valve Stenosis

The cardiac valve orifice is abnormally narrow, to a severe degree. (ACC)


Urinary Tract Diverticulum

A pouch or sac-like protrusion in the urinary tract.


Hemorrhage of testis

Bleeding originating from the testis.


Resuscitated Cardiac Arrest Event

Cardiac arrest that is reversed, usually by CPR and/or defibrillation or cardioversion, or cardiac pacing.


Disturbance of Skin Sensation

Disruption of the normal functioning of the sensory nerves in the skin.


Early Stillbirth

Delivery of a dead fetus greater than 22 weeks but less than 28 weeks gestational age, and/or whose birth weight is greater than 500 grams but less than 1,000 grams.


Antibiotic-associated diarrhea

Diarrhea that is associated with current or recent antibiotic use.


Intraoperative Ocular Injury

Damage to the eye during a surgical procedure.


Neonatal melena

Abnormally dark tarry feces containing blood, usually due to gastrointestinal bleeding or swallowed maternal blood in neonates.


Congenital jejunal stenosis

Narrowing of the lumen of the jejunum that is present at birth.


Opioid-Induced Constipation

Constipation that results from, or follows, treatment with an opioid or opioid-containing medication.


Closed injury of kidney

Trauma to the kidney without indication of associated damage to the skin and other internal and external tissues.


Paroxysmal atrioventricular block

An electrocardiographic finding of the sudden onset of transient AV block, which is often associated with preexisting conduction disorders. (CDISC)


Arm Or Hand Hypoesthesia

Consisting of abnormally decreased sensitivity, particularly to touch in the arm or hand.


Congenital ileal stenosis

Narrowing of the lumen of the ileum that is present at birth.


Surgical Shock

Hypoperfusion of body tissues occurring during or after a surgical procedure, and resulting in cellular injury and vital organ dysfunction.


Cardiac perforation

The presence of an acquired hole in the heart. Cardiac perforation may or may not be symptomatic and may or may not be self sealing. (ACC)


Female Reproductive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the female reproductive system.


Sprain

A stretching or tearing of a ligament.


Ambulation or Postural Difficulties

Any persistent problem with walking, gait or maintaining posture (sitting, standing).


Central Nervous System Signs and Symptoms

Signs and symptoms associated with disturbances within the central nervous system, which includes the brain, spinal cord and meninges.


Intraoperative Digestive System Injury

Damage to any part of the digestive system during a surgical procedure.


Proprioceptive Hallucination

Perception of the orientation of the body in space, manifesting as a sensation of floating, flying, in the absence of a corresponding stimulus.


Syncope with Exertion

A condition in which syncope occurs either during or after physical activity. (ACC/AHA)


Vasodepressor Syncope

A condition in which neurally-mediated syncope occurs in which the blood pressure falls and the heart rate increases. (ACC/AHA)


Cardiac Arrest Prior to Percutaneous Coronary Intervention

Cardiac arrest which occurs before a percutaneous coronary intervention can take place. (ACC)


Stenosis of bladder neck

Narrowing or stricture of the bladder neck.


Neonatal Vaginal Discharge

Secretions which may be thin or tenacious, mucoid or glairy, grayish or milky, occasionally blood tinged, that originate in the vagina and are a consequence of the residual influence of maternal estrogen.


Vasovagal Reaction

Sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the activity of the vagus nerve. It may be triggered by emotions of fear or pain or gastrointestinal upset and may be relieved by lying down while keeping the legs elevated.


Illegal Abortion

Unlawfully induced expulsion of all products of conception.


Postcoital bleeding

Non-menstrual bleeding that occurs during or after sexual intercourse.


Hemorrhage of vas deferens

Bleeding originating from the vas deferens.


Immediate Postpartum Hemorrhage

Cumulative blood loss of greater than or equal to 1000 ML or blood loss accompanied by signs or symptoms of hypovolemia within 24 hours following the birth process (includes intrapartum loss). (reVITALize)


Infectious Hidradenitis

Hidradenitis that is caused by an infectious agent, usually a bacterium.


Gastric Stenosis

Narrowing of the lumen of the stomach.


Skin Type

A distinctive characteristic of the skin marked by the amount of sebum secreted by sebaceous glands.


Binocular Diplopia

Perception of two images secondary to misalignment of the eyes.


Gum injury

Trauma to the gingiva


Atrioventricular Reentrant Tachycardia by ECG Finding

An electrocardiographic finding of a regular supraventricular tachycardia which utilizes an atrioventricular bypass tract as its retrograde limb (orthodromic tachycardia) or as its antegrade limb (antidromic tachycardia). QRS complexes during sinus rhythm may show preexcitation. During orthodromic tachycardia the preexcitation is not present and a retrograde P wave may appear after the QRS complex. During antidromic tachycardia the QRS complex is preexcited. (CDISC)


Esophageal anastomotic stricture

Luminal narrowing at the site of surgical resection and reconstruction of the esophagus.


Labial Fusion

Usually found in girls between 6 months and 6 years of age, this condition occurs wherein the labia grow together instead of as 2 separate folds, thereby blocking the opening of the vagina. It is caused by conditions such as repeated diaper rash, urine and stool infections, and sexual abuse. The condition often spontaneously corrects or responds to the application of estrogen cream.


Fecal Urgency

A continual or recurrent inclination to evacuate the bowels.


Eye foreign bodies

External material inside the eyeball.


Infertility Related to Medical Condition

Infertility that is associated with a medical condition.


Rathke Cleft Cysts

Rathke's pouch cysts are rarely symptomatic in the first two decades of life though they may produce symptoms in the third and fourth decades of life.  When the cysts do present in the first decades of life, the symptoms are generally associated with diabetes insipidus or other conditions related to hypopituitarism.


COVID-19-Associated Acute Digestive System Injury

Acute digestive system injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Hypertension Secondary To Endocrine Disorders

Evidence of hypertension secondary to endocrine disorders.


In Utero Bowel Perforation

Bowel perforation in utero that may result in meconium peritonitis.


Benign congenital hypotonia

Mild hypotonia that usually appears early in infancy and has a favorable outcome. It is not a manifestation of another disorder that may cause hypotonia (e.g., cerebral palsy or muscular dystrophy).


Malignant biliary obstruction

Blockage in the biliary tract caused by a malignant neoplasm.


Hepatojugular Reflex

Distension of the neck veins precipitated by sustained pressure over the liver while patient is semi-recumbent. With normal heart function, pressure on the liver does not elevate the venous blood level in the neck veins.


Aortic Injury

Damage to the aorta from traumatic or pathologic processes.


Secondary caries

A carious lesion adjacent to an existing restoration.


Reflex

An automatic instinctive unlearned reaction to a stimulus.


Focal Motor Weakness

Impairments of brain function, the nerve or spinal cord that affect a specific region of the body.


psychogenic syncope

A condition in which syncope occurs due to a conversion disorder. (ACC/AHA)


Conjunctival cyst

Abnormal fluid filled sac within the conjunctiva.


Urostomy Site Bleeding

Hemorrhage from the urostomy site.


Spontaneous Preterm Birth

Preterm birth from 20 weeks to 36 weeks, 6 days of gestation associated with one of the following: classic preterm labor or preterm premature rupture of membranes.


Peritumoral Brain Edema

An intracranial edema that develops around a tumor in the meninges or brain.


Perforation of jejunum

A rupture in the jejunal wall due to traumatic or pathologic processes.


Prostatic perforation

An opening in the prostate gland due to traumatic or pathologic processes.


Heat Sensation

An internal feeling of being warmer without a concomitant change in the ambient environment. (ACC/AHA)


Varicose veins of lower extremity

An abnormally dilated superficial vein in the legs.


Injury of cardiac valve

An event causes abnormal valve function; this is usually a tear in leaflet or chordae tendinae and manifests as a new regurgitant. (ACC)


Muscle Weakness Trunk

A reduction in the strength of the trunk muscles.


Fallopian tube stenosis

Narrowing of the lumen of the fallopian tube.


Blood Pressure Finding

A test result that reports the diastolic and systolic pressure of the blood.


Syncope with High Risk Cardiac Characteristics

A sudden loss of consciousness with loss of postural tone not related to anesthesia with high risk characteristics. High risk characteristics include non-ischemic dilated cardiomyopathy, or ischemic heart disease with significant ventricular dysfunction, hypertrophic cardiomyopathy, Brugada Syndrome, or Long QT Syndrome. (ACC)


COVID-19-Associated Acute Intestinal Injury

Acute intestinal injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Berry Aneurysm

A small cerebral artery aneurysm, characterized by a saccular appearance, that typically forms at the junction of vessels in the circle of Willis.


Cisplatin-Induced Tinnitus

Tinnitus that is caused by exposure to cisplatin.


Uterine Cervical Stenosis

Congenital or acquired narrowing of the lumen of the uterine cervix.


Rectal Anastomotic Leakage

Leakage due to breakdown of a rectal anastomosis.


Grade 3 Seizure, ASTCT ICANS

Any clinical seizure focal or generalized that resolves rapidly or nonconvulsive seizures on EEG that resolve with intervention, as defined by the American Society for Transplantation and Cellular Therapy (ASTCT) and the Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) Consensus Grading for Adults.


Congenital obstruction of ureteral orifice

Complete or partial blockage of the ureter at the point where it enters the bladder that is present at birth.


Pancreatic Anastomotic Leakage

Leakage due to breakdown of a pancreatic anastomosis.


Digestive System Finding

Symptoms, physical examination results, and/or laboratory test results related to the digestive system.


Muscle Weakness Left-Sided

A reduction in the strength of the muscles in the left side of the body.


Ventricular Tachycardia by ECG Finding

An electrocardiographic finding of three or more consecutive complexes of ventricular organ with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC)


Varicose veins of lower extremities with inflammation

Inflammation of enlarged and tortuous veins in the hip, thigh, leg and/or foot.


Blood Clot

An aggregation of blood factors, primarily platelets and fibrin with entrapment of cellular elements, frequently causing vascular obstruction at the point of its formation.


Spermatic Cord Perforation

An opening in the wall of the spermatic cord.


Hemorrhage in bile duct

Bleeding originating from the bile duct.


Closed injury of eyeball

Traumatic injury to one or more intraocular structures without full thickness wound of the eyewall (sclera and cornea). (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Hemorrhage of pancreas

Bleeding originating from the pancreas.


Cardiac Arrest Requiring Cardiopulmonary Resuscitation

Cardiac arrest that is treated by CPR and/or defibrillation, regardless of outcome.


Integumentary System Finding

Symptoms, physical examination results, and/or laboratory test results related to the integumentary system.


Diplopia, Unilateral

Perception of more than one image when viewing with one eye.


Pharyngeal Stenosis

Narrowing of the pharyngeal airway.


Neutrophilic Eccrine Hidradenitis

Painful red or pink edematous nodules most commonly found on the palmar and/or plantar regions.


Injury of nose

Trauma to the nose.


Traumatic chylothorax

Accumulation of lymph fluid in the pleural cavity as a result of thoracic trauma.


Jaundice, Hemolytic

Jaundice occurring as a result of red blood cell rupture.


Immune-Mediated Diarrhea

Diarrhea caused by an immune reaction to an antigen, including a therapeutically administered agent.


Indicated Preterm Birth

Preterm birth from 20 weeks to 36 weeks, and 6 days of gestation that is necessitated by the medical condition of the mother or fetus.


Arteriovenous graft stenosis

Narrowing of the lumen of an arteriovenous graft.


Acquired supradiaphragmatic diverticulum of esophagus


Pericardial Effusion Related to COVID-19

Pericardial effusion in a patient with probable or confirmed acute COVID-19.


Testicular perforation

A rupture through the testicular tissue.


Arrhythmia by ECG Finding

An arrhythmia that is detected on an electrocardiograph.


Late Pregnancy Loss

The loss of a pregnancy between 13 and 22 weeks.


Carious Dentin

Tooth decay that has invaded the dentin, creating dentin that is partially demineralized and containing mineral crystals in the tubules.


Myocardial Contusions

A bruise to the heart.


Spermatic cord stenosis

Narrowing or stricture of the spermatic cord.


Faceplant

A syncopal event in which there is no attempt to protect oneself from the effects of the fall.


Acral Erythema

Reddening of the palmar and plantar regions of the body with occasional involvement of the distal extremities.


Injury to kidney with open wound into cavity

Trauma to the kidney associated with a break in the tissue that extends into the retroperitoneum.


Large Intestinal Anastomotic Leakage

Leakage due to breakdown of a large intestinal anastomosis.


Grade 4 Seizure, ASTCT ICANS

Life-threatening prolonged seizure (>5 min); or repetitive clinical or electrical seizures without return to baseline in between seizures, as defined by the American Society for Transplantation and Cellular Therapy (ASTCT) and the Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) Consensus Grading for Adults.


Congenital Testicular Failure

Testicular failure, the cause of which is present at birth.


Miscarriage in second trimester

Pregnancy loss between 14 weeks 0 days and 21 weeks 6 days gestation.


Diminished mental function after chemotherapy.


Postpartum Shock

Severe loss of blood pressure leading to inadequate tissue perfusion after the delivery of the fetus.


Acquired solitary multilocular renal cyst

A single cyst in the kidney with several compartments.


injury of esophagus with open wound into cavity

Trauma to the esophagus associated with a break in the tissue that extends into the thoracic cavity.


Left Bundle Branch Block by ECG Finding

An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the left ventricle, manifested as a widened initial portion of the QRS complex in leads V5, V6, I and aVL and with QRS duration greater than or equal to 120 ms. (CDISC)


Persistent Fetal Bradycardia

A decrease in the fetal heart beat rate below 110 per minute or below the normal baseline value expected for the particular fetal age for a period of more than 10 minutes.


Contusion of liver

Bruising of the liver.


Rupture of globe

Full thickness wound of the eyewall (cornea and/or sclera) due to blunt trauma. (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Intraocular Pressure

The fluid pressure within the eye.


Cardiogenic Shock Stage A Related to COVID-19

Clinical signs of warmth and perfusion without volume overload or hypoperfusion and with a normal cardiac index in a patient with probable or confirmed acute COVID-19 that is not currently experiencing signs or symptoms of cardiogenic shock but is at risk for its development. These patients may include those with large acute myocardial infarction or prior infarction, or those with acute or acute on chronic heart failure symptoms.


Cardiac Arrest Requiring Defibrillation

Cardiac arrest that is treated by defibrillation, regardless of outcome.


Injury of liver without open wound into abdominal cavity

Trauma to the liver without indication of associated damage to the skin and other internal and external tissues.


Hemorrhage of liver

Bleeding originating from the liver.


Left ventricular aneurysm

A bulge or ballooning in the wall of the left ventricle of the heart.


Nontraumatic rupture of bladder

Rupture in the bladder wall due to a pathologic process, in the absence of trauma.


Distributive Shock Related to COVID-19

Systemic vasodilation leading to decreased blood flow to organs in a patient with probable or confirmed acute COVID-19.


Cerebral Venous Aneurysm

A balloon type pouch or bulge in the wall of a cerebral vein.


Rectal Obstruction

Blockage of the normal flow of the intestinal contents in the rectum.


Foot Injuries

Trauma to the foot.


Urethral Perforation

A rupture in the wall of the urethra due to traumatic or pathologic processes.


Intraoperative Hepatobiliary Injury

Damage to the hepatic parenchyma and biliary tract during a surgical procedure.


Central nervous system epidermoid tumor

A lesion which is characterized by an irregularly nodular opalescent wall which has caused it to be termed a "pearly tumor". The Intramural contents are soft and waxy with a variable amount of cholesterol.


Laryngopharyngeal Dysesthesia

A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx.


Legally Induced Abortion

Lawfully induced expulsion of all products of conception.


Prostatic Obstruction

Squeezing of the urethra secondary to enlargement of the prostate gland, resulting in voiding symptoms (straining to void, slow urine stream, and incomplete emptying of the bladder).


Fetal Malpresentation

Any presentation other than a vertex presentation. (reVITALize)


Decreased Best Corrected Visual Acuity

Diminished clarity of vision despite optimal optical correction (glasses and/or contacts).


Eye Finding

Symptoms, physical examination results, and/or laboratory test results related to the eye.


Lupus Headache

A severe, persistent headache that occurs in patients with systemic lupus erythematosus, and is nonresponsive to narcotic analgesia.


Unspecified postpartum hypertension

High blood pressure in the period of time immediately after labor and delivery.


idiopathic precocious puberty

Precocious puberty for which no underlying cause can be identified.


Normal Sinus Rhythm

An electrocardiographic finding of an atrial rhythm which originates from the sinoatrial node that is considered normal for the population. There are no extra beats or conduction abnormalities. (CDISC)


Late Preterm Birth

Birth when a fetus is between 34 weeks and 0 days through 36 weeks and 6 days gestational age.


Back Arching

A convex curvature of the spine that occurs when an individual thrusts forward the shoulders and pulls back the abdomen.


Antepartum Stillbirth

Fetal death greater than or equal to 20 weeks of gestation prior to labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond.


Injury of pancreas

Trauma to the pancreas.


Urostomy Stenosis

Narrowing of the opening of a urostomy.


Retinal damage

Injury to the retina due to advanced age, toxicity, exposure to bright lights, or trauma.


Syncope due to Pulmonary Hypertension

A condition in which syncope occurs associated with a sudden and severe increase in pulmonary vascular resistance. (ACC/AHA)


Pharyngeal Dysesthesia

An unusual sensation in the area of pharynx. It may be the initial manifestation of seizures associated with temporal lobe epilepsy.


Vessel perforation

Damage to a blood vessel resulting from a full thickness disruption in the integrity of the vessel wall.


Foreign Body in Digestive Tract

Extraneous material located within the gastrointestinal tract.


Ocular Contusion

A closed globe injury without violation of the eyewall (cornea and/or sclera), resulting in injury to one or more intraocular structures. (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Acute Ischemic Limb Related to COVID-19

A sudden or severe decrease in limb perfusion in a patient with probable or confirmed acute COVID-19, usually producing new or worsening symptoms or signs, and often threatening limb viability or resulting in limb amputation.


Atrial perforation

A rupture in atrial tissue due to traumatic or pathologic processes.


Cardiovascular System Finding

Symptoms, physical examination results, and/or laboratory test results related to the cardiovascular system.


Second trimester bleeding

Excessive blood loss within the second trimester but prior to onset of labor.


Superior vena cava stenosis

Abnormal narrowing of the lumen of the superior vena cava.


Hemorrhage of colon

Bleeding originating from the colon.


Cold Sensation

An internal feeling of being cooler without a concomitant change in the ambient environment. (ACC/AHA)


Injury to Inferior Vena Cava

Damage to the inferior vena cava from traumatic or pathologic processes.


Immune System Finding

Symptoms, physical examination results, and/or laboratory test results related to the immune system.


Syncope Related to COVID-19

Syncope in a patient with probable or confirmed acute COVID-19.


Cyst of parathyroid

An epithelium-lined, fluid-filled cyst containing parathyroid hormone that is usually located in an inferior parathyroid gland, but may be found in other locations in the neck or mediastinum.


Malignant pericardial effusion

Presence of fluid in the pericardial space as a complication of malignant disease.


Laceration of esophagus

A torn, ragged, mangled wound, or an accidental cut of esophagus.


Miscarriage in first trimester

Pregnancy loss at less than 14 weeks 0 days gestation.


Hemorrhage from ureter

Bleeding originating from the ureter.


Head and Neck Finding

Symptoms, physical examination results, and/or laboratory test results related to the head and neck.


Dissecting Thoracic Aortic Aneurysm

A dissecting aneurysm formed between the intimal and medial layers of the wall of the proximal portion of the descending aorta proceeding from the arch of the aorta.


Biliary Anastomotic Leakage

Leakage of bile due to breakdown of a biliary anastomosis.


Fetal Finding

Any intrauterine symptom or result related to the fetus.


Incomplete Right Bundle Branch Block by ECG Finding

An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the right ventricle, manifested by a widened initial portion of the QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration less than 120 ms. (CDISC)


Disturbance in Bowel Function

Abnormal functioning of the small and/or large intestine.


Acquired chylothorax

Chylothorax that results from malignancies (usually lymphoma), trauma to the thoracic duct, tuberculosis, or sarcoidosis.


Heart Injuries

Trauma to the cardiac muscle or valves.


Respiratory System Finding

Symptoms, physical examination results, and/or laboratory test results related to the respiratory system.


Refractory Erectile Dysfunction

Erectile dysfunction that does not respond to treatment.


Level of Consciousness

The level of awareness of an organism.


Locally Advanced Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Vulvar Acquired Melanocytic Nevus

A benign nevus that arises from the vulva during childhood and grows with increasing age.


Cocarboxylase

An organic chloride salt of thiamine(1+) diphosphate.


Grade 3 Tooth Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Tooth Infection, CTCAE

A disorder characterized by an infectious process involving a tooth.


Grade 4 Tooth Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Tooth Infection, CTCAE

Death


Grade 2 Tooth Infection, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Mucous polyp of cervix

A polypoid lesion that arises from the cervix and contains mucus.


Grade 2 Lower Gastrointestinal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


WHO Grade 1 Glioma

A category of low grade gliomas that includes subependymal giant cell astrocytoma, pilocytic astrocytoma, angiocentric glioma, and subependymoma.


Third Ventricle Pilocytic Astrocytoma

A pilocytic astrocytoma occurring in the third ventricle.


Recurrent Pilocytic Astrocytoma

The reemergence of pilocytic astrocytoma after a period of remission.


Adult Pilocytic Astrocytoma

A pilocytic astrocytoma occurring in adults.


Recurrent WHO Grade 1 Glioma

The reemergence of WHO grade 1 glioma after a period of remission.


Adult Subependymoma

A subependymoma that occurs during adulthood.


Refractory WHO Grade 1 Glioma

WHO grade 1 glioma that is resistant to treatment.


Adult Subependymal Giant Cell Astrocytoma

A subependymal giant cell astrocytoma occurring in adults.


Recurrent Childhood Subependymal Giant Cell Astrocytoma

The reemergence of subependymal giant cell astrocytoma in childhood after a period of remission.


Childhood Subependymal Giant Cell Astrocytoma

Subependymal giant cell astrocytoma that occurs during childhood.


Recurrent Childhood Pilocytic Astrocytoma

The reemergence of pilocytic astrocytoma in childhood after a period of remission.


Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Perinatal intracranial hemorrhage

Bleeding within the skull of a newborn infant occurring around the time of birth.


Perinatal subependymal hemorrhage with intraventricular and intracerebral extension

A hemorrhage that involves the subependymal region, the lateral cerebral ventricles and the brain tissue occurring around the time of birth.


Subependymal haemorrhage

Bleeding within the subependymal germinal matrix.


Intraventricular hemorrhage of prematurity

Bleeding within the cerebral ventricles in a preterm infant.


Intraventricular Hemorrhage Related to Birth

Bleeding into the cerebral ventricles that occurs during labor and/or delivery.


Grade 2 Intraventricular Hemorrhage of the Newborn

Bleeding into the lateral cerebral ventricles of a newborn infant without acute ventricular dilatation.


Intraventricular (nontraumatic) hemorrhage, grade 3, of fetus and newborn

Bleeding into the lateral cerebral ventricles of a newborn infant with ventricular dilatation directly attributable to the acute bleeding.


Intracranial Hemorrhage Related to Birth

Bleeding within the skull of a newborn infant occurring during labor and/or delivery.


Intraventricular Hemorrhage with Parenchymal Hemorrhage of the Newborn

Bleeding into the lateral cerebral ventricles and the adjacent brain tissue of a newborn infant.


Cerebral Hemorrhage Related to Birth

Intracranial bleeding in the tissue of the cerebrum of a newborn infant occurring during labor and/or delivery.


Grade 3 Ovary Intra-Operative Injury, CTCAE


Parotid Gland Warthin Tumor

An adenoma that arises from the parotid gland. It is characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. A strong association with smoking has been reported. It typically presents as a painless swelling in the lower portion of the parotid gland.


Skin Cavernous Hemangioma

A cavernous hemangioma arising from the skin.


Penile Lymphoepithelioma-Like Carcinoma

A variant of penile squamous cell carcinoma characterized by the presence of islands of malignant cells with uniform vesicular nuclei and prominent nucleoli, and a dense lymphocytic infiltrate.


Penile Carcinoma Cuniculatum

A variant of verrucous carcinoma of the penis. It is characterized by a labyrinthine growth pattern.


Penile Lymphoma

A lymphoma that arises from penile skin, subcutis, corpora cavernosa, and spongiosum. Diffuse large B-cell lymphoma is the most common primary penile lymphoma. (WHO 2016)


Stage 0is Penile Cancer AJCC v8

Stage 0is includes: Tis, N0, M0. Tis: Penile cancer with a finding of carcinoma in situ (penile intraepithelial neoplasia [PeIN]). N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Refractory Penile Carcinoma

Penile carcinoma that is resistant to treatment.


Penile Lymphangioma

A lymphangioma that occurs in the skin of the penis.


Childhood Malignant Penile Neoplasm

A rare malignant neoplasm of the penis that occurs during childhood.


Stage IIA Penile Cancer AJCC v8

Stage IIA includes: (T1b, N0, M0); (T2, N0, M0). T1b: Penile cancer with tumor exhibiting lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid). T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage III Penile Cancer AJCC v8

Stage III includes: IIIA: T1-3, N1, M0; IIIB: T1-3, N2, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N1: Penile cancer with two or less unilateral inguinal metastases, no extranodal extension. N2: Penile cancer with three or more unilateral inguinal metastases or bilateral metastases. M0: No distant metastasis. (AJCC 8th ed.)


Penile Hemangioma

A hemangioma that occurs in the skin of the penis.


Grade II Penile Intraepithelial Neoplasia

Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy the lower two thirds of the epithelial thickness.


Penis carcinoma recurrent

A carcinoma of the penis that reappears after a period of remission.


Penile Mucosal Melanoma

A melanoma that arises from the mucosa of the penis.


Penile Human Papillomavirus-Independent Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the penis and is not caused by human papillomavirus infection. Morphologic variants include pseudohyperplastic, pseudoglandular, verrucous, papillary, and sarcomatoid carcinoma.


Penile intraepithelial neoplasia

A precancerous neoplastic lesion that arises from the penis. It is characterized by dysplastic changes of the squamous epithelium with an intact basement membrane.


Bowenoid papulosis of penis

A cutaneous, usually multifocal lesion in the penis characterized by the presence of verrucous papules.  It is caused by human papillomavirus infection.  Morphologically there is bowenoid dysplasia present.  Progression to invasive carcinoma is infrequent.


Penile Schwannoma

A schwannoma that occurs in the penis.


Myointimoma

A rare benign mesenchymal neoplasm that occurs in the glans and corpora of the penis. It is characterized by the proliferation of spindle-shaped myofibroblasts in the intravascular spaces.


Penile Neurofibroma

A neurofibroma that occurs in the penis.


Basaloid (Undifferentiated) Penile Intraepithelial Neoplasia

Intraepithelial neoplasia of the penis characterized by full-thickness replacement of the squamous epithelium by immature, small, monotonous, basophilic cells. The cells have round to oval nuclei, inconspicuous nucleoli, and scant cytoplasm. Apoptosis and mitotic figures are prominent. (WHO 2016)


Stage IV Penile Cancer AJCC v8

Stage IV includes: (T4, Any N, M0); (Any T, N3, M0); (Any T, Any N, M1). T4: Penile cancer with tumor invading into adjacent structures (i.e., scrotum, prostate, pubic bone). N3: Penile cancer with extranodal extension of lymph node metastases or pelvic lymph node metastases. M1: Distant metastasis present. (AJCC 8th ed.)


Penile Clear Cell Squamous Cell Carcinoma

A variant of penile squamous cell carcinoma characterized by the presence of malignant cells with clear cytoplasm.


Penile Squamous Cell Carcinoma, Not Otherwise Specified

A penile squamous cell carcinoma characterized by the absence of special morphologic features and lack of information on p16 immunohistochemistry and human papilloma virus testing status.


Warty (Bowenoid) Penile Intraepithelial Neoplasia

Intraepithelial neoplasia of the penis characterized by a slightly spiking papillomatous surface with atypical parakeratosis. There is prominent cellular pleomorphism, koilocytosis, and mitoses. Unlike in basaloid penile intraepithelial neoplasia, there is squamous maturation. (WHO 2016)


Stage IIIA Penile Cancer AJCC v8

Stage IIIA includes: T1-3, N1, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N1: Penile cancer with two or less unilateral inguinal metastases, no extranodal extension. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIB Penile Cancer AJCC v8

Stage IIB includes: T3, N0, M0. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Condyloma Acuminatum

A human papillomavirus-related benign neoplasm affecting the penis. Most often it arises from the glans penis in young men. It usually presents with a nodular wart. Morphologically, it is characterized by an exophytic papillary proliferation of squamous cells and acanthosis. Most cases either resolve spontaneously or do not recur following removal.


Penile Adenosquamous Carcinoma

An extremely rare carcinoma that arises from the penis and is characterized by the presence of glandular and squamous components.


Penile Cancer by AJCC v8 Stage

A term that refers to the staging of penile cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to penile squamous cell carcinoma and associated histologic subtypes. It does not apply to urethral carcinomas, sarcomas, and melanomas. (from AJCC 8th Ed.)


Penile Cutaneous Melanoma

A melanoma that arises from the skin of the penis.


Differentiated penile intraepithelial neoplasia

Intraepithelial neoplasia of the penis that is not caused by human papillomavirus infection. It usually presents as a solitary white or pink macule or plaque that may be slightly elevated. A background of long-standing lichen sclerosus is often present. It is characterized by a thickened epithelium, subtle abnormal cellular maturation, and atypical basal layer cells. Parakeratosis is common. (WHO 2016)


Penile Pseudohyperplastic Carcinoma

A multifocal, extremely differentiated squamous cell carcinoma of the penis. It typically occurs in older patients and is associated with lichen sclerosus.


Adult Penile Carcinoma

A carcinoma of the penis that occurs during adulthood.


Penile Epithelioid Hemangioendothelioma

An epithelioid hemangioendothelioma that occurs in the penis.


Penile Leiomyoma

A leiomyoma that occurs in the penis.


Penile Soft Tissue Neoplasm

A rare mesenchymal neoplasm that arises from the penis.


Penile Pseudoglandular Carcinoma

A penile squamous cell carcinoma characterized by the formation of gland-like structures.


Stage 0 Penile Cancer AJCC v8

Stage 0 includes: 0is: Tis, N0, M0; 0a: Ta, N0, M0. Tis: Penile cancer with a finding of carcinoma in situ (penile intraepithelial neoplasia [PeIN]). Ta: Penile cancer with a finding of noninvasive localized squamous cell carcinoma. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIB Penile Cancer AJCC v8

Stage IIIB includes: T1-3, N2, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N2: Penile cancer with three or more unilateral inguinal metastases or bilateral metastases. M0: No distant metastasis. (AJCC 8th ed.)


Human Papillomavirus-Related Penile Intraepithelial Neoplasia

Intraepithelial neoplasia of the penis caused by human papillomavirus infection.


Penile Malignant Peripheral Nerve Sheath Tumor

A rare malignant peripheral nerve sheath tumor that occurs in the penis.


Penile Papillary-Basaloid Carcinoma

A variant of penile basaloid squamous cell carcinoma. It is characterized by a papillary exophytic or endophytic growth pattern.


Stage 0a Penile Cancer AJCC v8

Stage 0a includes: Ta, N0, M0. Ta: Penile cancer with a finding of noninvasive localized squamous cell carcinoma. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Low Grade Penile Intraepithelial Neoplasia

Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy the lower one third of the epithelial thickness.


Penile Epithelioid Hemangioma

An epithelioid hemangioma that occurs in the skin of the penis.


High Grade Penile Intraepithelial Neoplasia

Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy either the lower two thirds of the epithelial thickness (grade II) or the entire thickness of the epithelium (grade III, Bowen atypia, or squamous cell carcinoma in situ).


Stage II Penile Cancer AJCC v8

Stage II includes: IIA: (T1b, N0, M0); (T2, N0, M0); IIB: (T3, N0, M0). T1b: Penile cancer with tumor exhibiting lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid). T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Warty-Basaloid Carcinoma

A squamous cell carcinoma that arises from the penis. It is characterized by warty (condylomatous) and basaloid features.


Penile Angiosarcoma

A rare angiosarcoma that affects the penis.


Warty-Basaloid Penile Intraepithelial Neoplasia

Intraepithelial neoplasia of the penis characterized by the presence of a variable mixture of warty and basaloid cells. (WHO 2016)


melanoma of penis

A melanoma that arises from the penis. It may be cutaneous or mucosal. The most common site of involvement is glans penis.


Metastatic Penile Cancer

Carcinoma of the penis that has spread from its original site of growth to another anatomic site.


Stage I Penile Cancer AJCC v8

Stage I includes: T1a, N0, M0. T1a: Penile cancer with tumor without lymphovascular invasion or perineural invasion and is not high grade (i.e., grade 3 or sarcomatoid). N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Mucoepidermoid Carcinoma

An extremely rare carcinoma that arises from the penis and is characterized by the presence of mucinous and squamous components.


Locally Advanced Penile Carcinoma

Penile carcinoma that has spread to nearby tissues or lymph nodes.


Grade 2 Dysphagia, CTCAE

Symptomatic and altered eating/swallowing


nitrogen-13 atom

The radioactive isotope of nitrogen with relative atomic mass 13.0057386. The longest-lived nitrogen radionuclide with half-life of 9.965 min.


nitrogen-14 atom

The stable isotope of nitrogen with relative atomic mass 14.003074. The most abundant (99.63 atom percent) isotope of naturally occurring nitrogen.


nitrogen-15 atom

The stable isotope of nitrogen with relative atomic mass 15.000109. The least abundant (0.368 atom percent) isotope of naturally occurring nitrogen.


Current Hepatitis B Infection

Hepatitis B infection is evident at the time of testing.


Grade 3 Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute Intrapartum Hypoxic Event

A sentinel hypoxic event occurring during labor, with evidence of fetal metabolic acidosis in the fetal umbilical arterial blood; a sudden and sustained fetal bradycardia or the absence of fetal heart rate variability in the presence of persistent, late, or variable decelerations (category III tracing); previously normal Apgar scores that are 0-3 beyond 5 minutes.


Stage IIIB Anal Cancer AJCC v8

Stage IIIB includes: T4, N0, M0. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Postoperative Hemorrhage

Bleeding occurring after completion of a surgical procedure, which may occur immediately or may be delayed, and which may or may not be wound related.


Grade 2 Proteinuria, CTCAE

Adult: 2+ and 3+ proteinuria; urinary protein 1.0-<3.5 g/24 hrs; Pediatric: Urine P/C (Protein/Creatinine) ratio 0.5-1.9


Grade 3 Proteinuria, CTCAE

Adult: Urinary protein >=3.5 g/24 hrs; 4+ proteinuria; Pediatric: Urine P/C (Protein/Creatinine) ratio >1.9


Grade 1 Proteinuria, CTCAE

1+ proteinuria; urinary protein > or = to ULN-<1.0 g/24 hrs


Uterine Corpus Spindle Smooth Muscle Tumor of Uncertain Malignant Potential

A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and is composed of neoplastic spindle cells.


Developmental and Epileptic Encephalopathy 65

An autosomal dominant form of developmental and epileptic encephalopathy, caused by mutation(s) in the CYFIP2 gene, encoding cytoplasmic FMR1-interacting protein 2.


A rare serous cystadenocarcinoma that arises from the paratesticular structures.


D-threonine

An optically active form of threonine having D-configuration.


Fumarate Hydratase-Deficient Renal Cell Carcinoma

A rare, highly aggressive renal cell carcinoma caused by germline or (in a subset) somatic mutation of fumarate hydratase gene. It arises mostly in the setting of hereditary leiomyomatosis-renal cell carcinoma syndrome.


Grade 3 Encephalitis Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; severe changes in mental status; self-limited seizure activity; focal neurologic abnormalities


Acephalostomia

A congenital defect characterized by the absence of most or all of the head, with the presence of a mouth-like opening on the upper thorax.


Grade 1 Colonic Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Hemorrhoidal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Myositis, Proliferative

A rapidly growing, poorly circumscribed, mass-forming proliferation that arises from the skeletal muscle. It is characterized by the presence of spindle-shaped fibroblasts, round ganglion-like cells, myxoid to collagenous stroma formation, and high mitotic activity. It recurs only rarely following local excision and does not metastasize.


Vascular Access Complication, CTCAE

A finding of a previously undocumented problem related to the vascular access site.


Grade 1 Vascular Access Complication, CTCAE

TPA administration into line with no intent for systemic therapy indicated


Grade 3 Vascular Access Complication, CTCAE

Pulmonary embolism, deep vein or cardiac thrombosis; intervention indicated (e.g., anticoagulation, lysis, filter, invasive procedure)


Grade 2 Vascular Access Complication, CTCAE

Device dislodgement, blockage, leak, or malposition; device replacement indicated


Grade 5 Vascular Access Complication, CTCAE

Death


Grade 4 Vascular Access Complication, CTCAE

Life-threatening consequences with hemodynamic or neurologic instability


Grade 4 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Pancreatic Beta Cell Adenoma

An adenoma arising from the beta cells of the pancreas.  It produces insulin.


Carcinoma of lower gum

A carcinoma of the oral cavity that arises from the lower gingiva.


Carcinoma of upper gum

A carcinoma of the oral cavity that arises from the upper gingiva.


Gingival Spindle Cell Carcinoma

A poorly differentiated squamous cell carcinoma that arises from the gingiva. It is characterized by the presence of malignant pleomorphic spindle cells.


Gingival Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the gingival mucosa. It presents as an ulcerated lesion or exophytic mass. The prognosis is usually poor.


Gingival Angiofibroma

A benign neoplasm arising from the fibrous soft tissues of the gingiva. It is characterized by the presence of spindle-shaped fibroblasts and numerous dilated vascular channels.


Lower Gingival Squamous Cell Carcinoma

A squamous cell carcinoma of the oral cavity that arises from the lower gingiva.


carcinoma of gingiva

A carcinoma of the oral cavity that arises from the upper or lower gingiva.


Upper Gingival Squamous Cell Carcinoma

A squamous cell carcinoma of the oral cavity that arises from the upper gingiva.


Retromolar Trigone Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the retromolar trigone. Pain, often radiating to the ear, is the presenting symptom. The prognosis is poor.


Paranasal sinus teratocarcinosarcoma (type)

A malignant sinonasal neoplasm with combined histological features of teratoma and carcinosarcoma, lacking malignant germ cell components. (WHO 2017)


carcinosarcoma of salivary gland

An aggressive, high grade malignant tumor that arises from the salivary gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Lacrimal Gland Carcinosarcoma

An aggressive, high grade malignant neoplasm that arises from the lacrimal gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Pleomorphic adenoma of parotid gland

A benign, slow-growing tumor that arises from the parotid gland.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation. It is the most common neoplasm of salivary gland origin and women are more often affected than men.


Recurrent Childhood Anaplastic Oligoastrocytoma

The reemergence of anaplastic oligoastrocytoma in childhood after a period of remission.


Malignant Mixed Tumor of the Major Salivary Gland

A malignant tumor arising from the parotid gland, submandibular gland, or sublingual gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Conjunctival Adenosquamous Carcinoma

A carcinoma that arises from the conjunctiva. It is characterized by the presence of a variable combination of squamous (epidermoid) cells and mucous cells, arranged in invasive sheets, cords, and ducts. (WHO 2018)


Stage III Uterine Corpus Adenosarcoma AJCC v8

Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Adenocarcinoma with cartilaginous and osseous metaplasia

An invasive adenocarcinoma characterized by focal or extensive cartilage and/or bone formation.


Recurrent Anaplastic Oligoastrocytoma

The reemergence of anaplastic oligoastrocytoma after a period of remission.


Uterine Carcinosarcoma, Homologous Type

A carcinosarcoma of the uterus characterized by the presence of sarcomatous elements that arise from the tissues of the uterus.


Uterine Corpus Adenosarcoma by AJCC v8 Stage

A term that refers to the staging of uterine corpus adenosarcoma according to the American Joint Committee on Cancer, 8th edition.


Testicular Mixed Embryonal Carcinoma and Teratoma with Seminoma

A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a mixture of embryonal carcinoma, a teratomatous component, and a seminomatous component.


Metastatic Endometrial Adenosquamous Carcinoma

Endometrial adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


mixed acinar-endocrine carcinoma of pancreas

A carcinoma that arises from the pancreas showing a mixture of acinar and neuroendocrine malignant cells.


Benign Cervical Mixed Epithelial and Mesenchymal Neoplasm

A neoplasm that arises from the cervix and is characterized by the presence of benign epithelial and benign mesenchymal elements. This category includes adenofibroma and adenomyoma.


Primary peritoneal carcinosarcoma

An extremely rare and highly aggressive malignant neoplasm arising from the peritoneum.  Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements.


Hybrid Salivary Gland Tumor

A rare neoplasm that arises from the salivary gland and consists of at least two histologically distinct types of tumor within the same topographic location. The tumor components can be either benign or malignant.


Uterine Carcinosarcoma, Heterologous Type

A carcinosarcoma of the uterus characterized by the presence of sarcomatous elements composed of tissues that are not found in the uterus (e.g., bone, cartilage, skeletal muscle).


Appendix Mixed Adenoneuroendocrine Carcinoma

A carcinoma that arises from the appendix.  It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Metastasizing Pleomorphic Adenoma of the Salivary Gland

A very rare pleomorphic adenoma of the salivary glands that metastasizes inexplicably, despite the benign histopathologic features.  The most common sites of metastasis are bone, lung, and head and neck.


Oropharyngeal Pleomorphic Adenoma

A pleomorphic adenoma that arises from the oropharynx.


Stage IIIA Uterine Corpus Adenosarcoma AJCC v8

Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Borderline Serous Cystadenofibroma

A neoplasm of low malignant potential arising from a site in the female reproductive system. Almost all cases have been reported in the ovary. It is characterized by the presence of cystic spaces which are lined by atypical serous epithelial cells. The surrounding ovarian stroma is fibrotic. There is no evidence of stromal invasion.


Advanced Uterine Corpus Carcinosarcoma

Uterine corpus carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIIC Uterine Corpus Adenosarcoma AJCC v8

Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Advanced Malignant Mixed Mesodermal (Mullerian) Tumor

A malignant mixed mesodermal (Mullerian) tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm


Stage I Uterine Corpus Adenosarcoma AJCC v8

Stage I includes: T1, N0, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Metastatic Cervical Adenosquamous Carcinoma

A cervical adenosquamous carcinoma that has spread to another anatomic site.


Testicular Mixed Choriocarcinoma and Seminoma

A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of choriocarcinoma and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


Metastatic Pancreatic Adenosquamous Carcinoma

Pancreatic adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


Skin Squamous Cell Carcinoma with Sarcomatoid Differentiation

A rare carcinoma of the skin characterized by the presence of squamous cell carcinomatous and sarcomatous components.


Sellar Mixed Germ Cell Tumor

A mixed germ cell tumor that arises from or adjacent to the sellar region.


Cellular Pleomorphic Adenoma

A pleomorphic adenoma with increased cellularity.


Metastatic Vaginal Adenosquamous Carcinoma

Vaginal adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


Anal Canal Mixed Adenoneuroendocrine Carcinoma

A carcinoma that arises from the anal canal.  It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Recurrent Childhood Oligoastrocytoma

The reemergence of oligoastrocytoma in childhood after a period of remission.


Hard Palate Pleomorphic Adenoma

A benign, slow-growing and painless neoplasm that arises from the minor salivary glands in the hard palate.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


carcinosarcoma of gallbladder

A carcinoma that arises from the gallbladder and it is characterized by the presence of a sarcomatous component.  The sarcomatous component may contain osteosarcoma, chondrosarcoma, or rhabdomyosarcoma elements.


Mixed neuroendocrine-non neuroendocrine neoplasm

A rare neoplasm that consists of neuroendocrine and non-neuroendocrine cellular components. At least 30% of either component should be present for the diagnosis to be made.


Metastatic Uterine Corpus Carcinosarcoma

Uterine corpus carcinosarcoma that has spread from its original site of growth to another anatomic site.


Testicular Mixed Embryonal Carcinoma and Teratoma

A malignant mixed germ cell tumor arising from the testis, characterized by the presence of an embryonal carcinomatous component and a teratomatous component.


Gallbladder Mixed Adenoneuroendocrine Carcinoma

A carcinoma that arises from the gallbladder and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Benign Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm

A mixed epithelial and mesenchymal neoplasm that arises from the hair follicle. It is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Sinonasal Pleomorphic Adenoma

A pleomorphic adenoma that arises from the sinonasal tract.


Metastatic Carcinosarcoma

Carcinosarcoma that has spread from its original site of growth to another anatomic site.


Recurrent Fallopian Tube Carcinosarcoma

The reemergence of fallopian tube carcinosarcoma after a period of remission.


Hybrid Salivary Gland Carcinoma

A rare carcinoma that arises from the salivary gland and consists of at least two histologically distinct types of carcinoma within the same topographic location. The carcinoma components usually are adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, and/or salivary duct carcinoma. Adenoid cystic carcinoma is commonly the predominant component.


Adult Mixed Glioma

A mixed glioma that occurs during adulthood.


Malignant chondroid syringoma

A rare malignant skin neoplasm that arises from a benign mixed tumor of the skin (chondroid syringoma).


Uterine Ligament Adenomyoma

A benign neoplasm that arises from the broad or other uterine ligaments. It is characterized by the presence of a glandular and a mesenchymal component.


Testicular Mixed Choriocarcinoma and Embryonal Carcinoma

A malignant mixed germ cell tumor that arises from the testis and is characterized by the presence of choriocarcinoma and embryonal carcinoma morphologic components.


Stage IIIB Uterine Corpus Adenosarcoma AJCC v8

Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Mixed parotid tumor

A benign or malignant neoplasm that arises from the parotid gland.  It is characterized by the presence of epithelial and mesenchymal elements.  This category includes pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and carcinosarcoma.


Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal-Type

A very rare testicular germ cell tumor that combines teratoma and yolk sac tumor. It usually affects young children. It is not associated with chromosome 12p amplification or germ cell neoplasia in situ.


Childhood Oligoastrocytoma

An oligoastrocytoma that occurs during childhood.


Gastric Mixed Adenoneuroendocrine Carcinoma

A carcinoma that arises from the stomach and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Minor Salivary Gland Carcinoma ex Pleomorphic Adenoma

A carcinoma that arises from a pleomorphic adenoma in the minor salivary glands.  Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months.  Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis.  In cases where there is invasion of the surrounding tissues, the clinical course is aggressive.


Oral Cavity Pleomorphic Adenoma

A benign, slow-growing and painless neoplasm that arises from the salivary glands in the oral cavity.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


Stage IA Uterine Corpus Adenosarcoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Uterine corpus adenosarcoma with tumor limited to the endometrium/endocervix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of choriocarcinoma and yolk sac tumor morphologic elements.  Patients may present with painless or painful testicular swelling.