Stage IVA Rectal Cancer AJCC v7

Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node). (AJCC 7th ed.)


Stage IIC Rectal Cancer AJCC v8

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Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Locally Advanced Colorectal Adenocarcinoma

Colorectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


A rare, invasive colorectal adenocarcinoma characterized by the presence of clusters of malignant glandular cells within stromal spaces.


Secondary malignant neoplasm of rectum

The spread of a malignant neoplasm to the rectum.  This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site.


Stage IIB Colon Cancer AJCC v7

Stage IIB includes: T4a, N0, M0. T4a: Tumor penetrates to the surface of the visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage I Duodenal Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invading the mucosa or submucosa only and is equal or less than 1 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Rectosigmoid Adenocarcinoma

An adenocarcinoma arising from the rectosigmoid area.  It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease.  Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits.  According to the degree of cellular differentiation, rectosigmoid adenocarcinomas are divided into well, moderately, and poorly differentiated.  Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.


Metastatic Colorectal Carcinoma

A carcinoma that arises from the colon or rectum and has metastasized to another anatomic site.


Stage IV Rectal Cancer AJCC v6

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th ed.)


Stage I Small Intestinal Gastrointestinal Stromal Tumor

Stage I includes: T1 or T2, N0, M0, Mitotic rate: Low.  T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm, but not more than 5 cm, in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Advanced Colon Carcinoma

Colon carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage III Rectal Cancer AJCC v8

Stage III includes: IIIA: (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIB Small Intestinal Gastrointestinal Stromal Tumor

Stage IIIB includes: (T2, N0, M0, Mitotic rate: High); (T3, N0, M0, Mitotic rate: High); (T4, N0, M0, Mitotic rate: High).  T2: Tumor more than 2 cm, but not more than 5 cm, in greatest dimension. T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension. T4: Tumor more than 10 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Colon Cancer by AJCC v6 Stage

A term that refers to the staging of colon carcinoma according to the American Joint Committee on Cancer, 6th edition.


Small intestine carcinoma recurrent

The reemergence of small intestine carcinoma after a period of remission.


Rectal Cribriform Comedo-Type Adenocarcinoma

A rare, invasive rectal adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.


Stage IIIB Small Intestinal Cancer AJCC v7

Stage IIIB includes: Any T, N2, M0. N2: Metastasis in four or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IV Rectal Cancer AJCC v8

Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b); IVC: (Any T, Any N, M1c). M1a: Metastasis to one site or organ without peritoneal metastasis. M1b: Metastasis to two or more sites or organs without peritoneal metastasis. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Colon Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the colon. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Colorectal Adenoma with Mild Dysplasia

An adenoma that arises from the colon or rectum.  It is characterized by the presence of mild epithelial dysplasia.


Stage IIC Colorectal Cancer AJCC v8

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colorectal Low Grade Intraepithelial Neoplasia

A precancerous neoplastic process that affects the colon or rectum.  It is characterized by mild epithelial dysplasia and mild architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


Refractory Rectal Squamous Cell Carcinoma

Rectal squamous cell carcinoma that is resistant to treatment.


Grade 3 Colorectal Adenocarcinoma

A colorectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with less than 50% glandular formation.


Stage II Ileal Neuroendocrine Tumor AJCC v8

Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Microsatellite Stable Colorectal Carcinoma

A microsatellite stable carcinoma that arises from the colon or rectum and has metastasized to other anatomic sites.


Stage 0 Colorectal Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ, intramucosal carcinoma (involvement of lamina propria with no extension through muscularis mucosae). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIC Colorectal Cancer AJCC v7

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Locally Advanced Colon Carcinoma

Colon carcinoma that has spread to nearby tissues or lymph nodes.


Stage IVA Colorectal Cancer AJCC v8

Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis to one site or organ without peritoneal metastasis. (AJCC 8th ed.)


Stage IV Jejunal Neuroendocrine Tumor AJCC v8

Stage IV includes: (T1, N0, N1, N2, M1); (T2, N0, N1, N2, M1); (T3, N0, N1, N2, M1); (T4, N0, N1, N2, M1). T1: Tumor invading lamina propria or submucosa and measuring 1 cm or less in size. T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis in less than 12 nodes. N2: Large mesenteric masses (larger than 2 cm) and/or extensive nodal deposits (12 or greater), especially those that encase the superior mesenteric vessels. M1: Distant metastasis. (AJCC 8th ed.)


Stage IV Rectal Cancer AJCC v7

Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Colon Adenoma with Severe Dysplasia

An adenoma that arises from the colon.  It is characterized by the presence of severe epithelial dysplasia.


Rectal Large Cell Neuroendocrine Carcinoma

A rare, aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the rectum. It is characterized by the presence of malignant large cells.


Small Intestinal Somatostatin-Producing Neuroendocrine Tumor

A somatostatin-producing neuroendocrine tumor that arises from the small intestine.


Small Intestinal Mucinous Adenocarcinoma

An invasive adenocarcinoma that arises from the small intestine.  It is composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation.


Colorectal Poorly Cohesive Adenocarcinoma

An adenocarcinoma that arises from the colorectal mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.


Intestinal Intraepithelial Neoplasia

A precancerous neoplastic process that affects the small or large intestine.  It is characterized by low or high grade dysplasia of the mucosal epithelium.  There is no evidence of invasion.


Congenital Abnormality of the Large Intestine

A malformation in any part of the large intestine that is present at birth.


Necrotizing Enterocolitis Totalis

A severe and often fatal form of necrotizing enterocolitis, in which diffuse ischemia, necrosis, and pneumatosis intestinalis are evident in the small and large intestine. Short bowel syndrome is common among survivors.


Stage IIB Small Intestinal Adenocarcinoma AJCC v8

Stage IIB includes: T4, N0, M0. T4: Tumor perforating the visceral peritoneum or directly invading other organs or structures (e.g., other loops of small intestine, mesentery of adjacent loops of bowel, and abdominal wall by way of serosa; for duodenum only, invasion of pancreas or bile duct). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colorectal Sporadic Serrated Polyp

A term that refers to a group of polypoid lesions in the colon and rectum that are characterized by the presence of serrated architecture of the epithelial component.  This group includes hyperplastic polyps, traditional serrated adenomas, and sessile serrated adenomas/polyps.


Rectal Epithelioid Cell Melanoma

An epithelioid cell melanoma arising from the rectum.


Stage IVB Rectal Cancer AJCC v7

Stage IVB includes: Any T, Any N, M1b. M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Undifferentiated Carcinoma of Colon

An invasive malignant epithelial tumor that arises from the colon.  There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation.


Duodenal Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a duodenal neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to well-differentiated neuroendocrine tumors of the duodenum. Carcinomas of the duodenum, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not included in this staging system. (from AJCC 8th Ed.)


Advanced Microsatellite Stable Colorectal Carcinoma

A microsatellite stable carcinoma that arises from the colon or rectum and has spread extensively to other anatomic sites or is no longer responding to treatment.


Jejunal Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a jejunal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This classification system applies to small bowel "carcinoid" tumors (NET G1 and G2, and rare well-differentiated G3) arising in the jejunum. This classification system does not apply to high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and neuroendocrine tumors of the duodenum. (from AJCC 8th Ed.)


Juvenile Polyp of the Small Intestine

A non-neoplastic hamartomatous polyp that arises from the small intestine.  It is characterized by the presence of tortuous and cystically dilated glands, edematous changes, and inflammation.


Stage IIB Rectal Cancer AJCC v8

Stage IIB includes: T4a, N0, M0. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Large intestinal mucositis

An inflammatory process affecting the mucous membrane of the large intestine.


Grade 5 Alcohol Intolerance, CTCAE

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Death


Thyroid-Binding Globulin Excess

Supranormal concentration of thyroid-binding globulin.


Variant Autoimmune Hepatitis

A form of autoimmune hepatitis (AIH) that has features of overlapping cholestatic autoimmune liver diseases including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), or autoimmune cholangitis (AIC).


Childhood Paranasal Sinus Carcinoma

A rare carcinoma of the paranasal sinus that occurs during childhood.


Childhood Head and Neck Neoplasm

A benign or malignant neoplasm that affects the anatomic structures of the head and neck region and occurs during childhood.


Childhood Benign Head and Neck Neoplasm

A childhood neoplasm that arises from the head and neck and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Ameloblastic Fibroma

An ameloblastic fibroma that occurs during childhood.


Childhood Odontogenic Neoplasm

A benign or malignant neoplasm that arises from tooth-forming tissues and occurs during childhood.


Childhood Thyroid Gland Follicular Adenoma

A follicular adenoma of the thyroid gland that occurs during childhood.


Childhood Head and Neck NUT Carcinoma

A NUT carcinoma that arises from the head and neck and occurs during childhood.


Childhood Ameloblastoma

An ameloblastoma that occurs during childhood.


Childhood Salivary Gland Carcinoma

A rare carcinoma of the salivary gland that occurs during childhood.


Childhood Laryngeal Squamous Papilloma

A squamous papilloma of the larynx that occurs during childhood.


Childhood Salivary Gland Pleomorphic Adenoma

A salivary gland pleomorphic adenoma that occurs during childhood.


Childhood Nasal Cavity Carcinoma

A rare carcinoma of the nasal cavity that occurs during childhood.


Childhood Ossifying Fibroma

An ossifying fibroma that occurs during childhood.


Childhood Adenomatoid Odontogenic Tumor

An adenomatoid odontogenic tumor that occurs during childhood.


Childhood Salivary Gland Acinic Cell Carcinoma

An acinic cell carcinoma of the salivary gland that occurs during childhood.


Childhood Craniopharyngioma

A craniopharyngioma that occurs during childhood.  The vast majority of cases are adamantinomatous craniopharyngiomas.  Clinical signs and symptoms include endocrine deficiencies and visual disturbances.


Childhood Odontogenic Myxoma

An odontogenic myxoma that occurs during childhood.


An adamantinomatous craniopharyngioma that occurs during childhood.


Sialoblastoma

A rare, congenital or perinatal, aggressive and potentially low-grade malignant basaloid neoplasm that occurs in the major salivary glands. It typically presents as a mass over the angle of the mandible. Most involve the parotid gland.


Childhood Salivary Gland Mucoepidermoid Carcinoma

A mucoepidermoid carcinoma of the salivary gland that occurs during childhood.


Childhood Malignant Head and Neck Neoplasm

A malignant neoplasm that affects the anatomic structures of the head and neck region and occurs during childhood.


Childhood Mucoepidermoid Carcinoma

A mucoepidermoid carcinoma that occurs during childhood.


Bone Erdheim-Chester Disease

Erdheim-Chester disease affecting the bone.


Grade 3 Gastrointestinal Stoma Intra-Operative Injury, CTCAE


Grade 2 Conjunctiva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Conjunctiva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Conjunctiva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Conjunctiva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Conjunctiva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Duodenal Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Esophageal Hemorrhage, CTCAE

A disorder characterized by bleeding from the esophagus.


Grade 2 Esophageal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 4 Esophageal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Esophageal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 1 Esophageal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 5 Esophageal Hemorrhage, CTCAE

Death


Recurrent Childhood Optic Nerve Glioma

The reemergence of optic nerve glioma in childhood after a period of remission.


Childhood Intracranial Neoplasm

A neoplasm that arises within the skull and occurs during childhood.


Recurrent Childhood Visual Pathway Glioma

The reemergence of visual pathway glioma in childhood after a period of remission.


Childhood Supratentorial Ependymoma ZFTA Fusion-Positive

A supratentorial ependymoma ZFTA fusion-positive that occurs during childhood.


Childhood Supratentorial Neoplasm

A neoplasm that affects the supratentorial region of the brain and occurs during childhood.


Childhood Benign Brain Neoplasm

A childhood neoplasm that arises from the brain and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Refractory Childhood Brain Neoplasm

A childhood brain neoplasm that is resistant to treatment.


Childhood Atypical Choroid Plexus Papilloma

An atypical choroid plexus papilloma that occurs during childhood.


Childhood Pineal Parenchymal Cell Neoplasm

A pineal parenchymal cell neoplasm that occurs during childhood.


Childhood Gliomatosis Cerebri

Gliomatosis cerebri that occurs during childhood.


Supratentorial Ependymoma, YAP1-MAMLD1 Fusion-Positive

A supratentorial ependymoma characterized by a gene fusion involving YAP1 and MAMLD1 genes.


Metastatic Childhood Malignant Brain Neoplasm

A childhood malignant neoplasm that arises from the brain and has spread from its original site of growth to other anatomic sites.


Childhood Dysembryoplastic Neuroepithelial Tumor

A dysembryoplastic neuroepithelial tumor that occurs during childhood.


Recurrent Childhood Gliomatosis Cerebri

The reemergence of gliomatosis cerebri in childhood after a period of remission.


Recurrent Childhood Brain Neoplasm

The reemergence of brain neoplasm in childhood after a period of remission.


Childhood Pineal Parenchymal Tumor of Intermediate Differentiation

A pineal parenchymal tumor of intermediate differentiation that occurs during childhood.


Childhood Diffuse Midline Glioma, H3 K27-Altered

A diffuse midline glioma, H3 K27-altered that occurs during childhood.


Childhood Cerebral Ependymoma, Not Otherwise Specified

An ependymoma, not otherwise specified that arises from the cerebral hemispheres and occurs during childhood.


Childhood Brain Anaplastic Astrocytoma

An anaplastic astrocytoma that arises from the brain and occurs during childhood.


Recurrent Childhood Visual Pathway Astrocytoma

The reemergence of visual pathway astrocytoma in childhood after a period of remission.


Childhood Brain Oligodendroglioma

An oligodendroglioma that arises from the brain and occurs during childhood.


Childhood Brain Glioblastoma

A brain glioblastoma that occurs during childhood.


Childhood Malignant Brain Neoplasm

A primary or metastatic malignant neoplasm affecting the brain during childhood.


Metastatic Childhood Malignant Neoplasm in the Brain

A childhood malignant neoplasm that has spread from its original site of growth to the brain.


Childhood Brain Neoplasm

A benign or malignant, primary or metastatic neoplasm of the brain occurring in children.


Childhood Benign Supratentorial Neoplasm

A childhood neoplasm that arises from the supratentorial region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Multinodular and Vacuolated Neuronal Tumor

A multinodular and vacuolated neuronal tumor that occurs during childhood.


Childhood Cerebral Diffuse Astrocytoma

A diffuse astrocytoma that arises from the cerebral hemispheres and occurs during childhood.


Advanced Childhood Malignant Brain Neoplasm

A childhood malignant brain neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Childhood Optic Nerve Astrocytoma

The reemergence of optic nerve astrocytoma in childhood after a period of remission.


Recurrent Childhood Cerebral Astrocytoma

The reemergence of cerebral astrocytoma in childhood after a period of remission.


Childhood Benign Cerebral Neoplasm

A childhood neoplasm that arises from the cerebrum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 2 Teeth Intra-Operative Injury, CTCAE


Retropharyngeal Neoplasm

A benign or malignant neoplasm that affects the retropharyngeal space.


Malignant Retropharyngeal Neoplasm

A primary or metastatic malignant neoplasm that affects the retropharyngeal space.


Benign Retropharyngeal Neoplasm

A neoplasm that arises from the retropharyngeal space and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 4 Rectal Perforation, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Rectal Perforation, CTCAE 5.0

A disorder characterized by a rupture in the rectal wall.


Grade 2 Rectal Perforation, CTCAE

Invasive intervention not indicated


Grade 5 Rectal Perforation, CTCAE

Death


Grade 3 Rectal Perforation, CTCAE

Invasive intervention indicated


Grade 2 Infant Sedation, AE

An adverse event in a newborn characterized by moderate sedation; limiting interactions and minor changes in feeding behavior; requiring increased monitoring.


Infant Sedation, AE

An adverse event in a newborn characterized by a state of a lowered level of consciousness.


Grade 4 Infant Sedation, AE

An adverse event in a newborn characterized by life-threatening sedation with cardiorespiratory instability; requiring urgent care change.


Grade 3 Infant Sedation, AE

An adverse event in a newborn characterized by severe sedation, major changes in feeding behavior; requiring support other than oral feeding (e.g. tube feeding).


Grade 1 Infant Sedation, AE

An adverse event in a newborn characterized by mild, self-limiting or transient sedation or sleepiness; transient loss of interactions; not requiring care change.


Group B Streptococcal Infection, Late-Onset

Infection of an infant from seven days to three months of life caused by Group B Streptococcus (Streptococcus agalactiae).


Group B Streptococcal Infection, Early-Onset

Infection of an infant from birth to less than seven days of life caused by Group B Streptococcus (Streptococcus agalactiae) from a colonized mother.


Stage IVC Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Umbilical hernia with gangrene

A protrusion of necrotic tissue through the abdominal wall under the skin near the umbilicus.


Grade 2 Dermal Change Lymphedema or Phlebolymphedema, CTCAE


Cerebral abscess

A bacterial, fungal, or parasitic abscess that develops in the cerebral hemispheres. Causes include skull trauma, middle ear infection, congenital heart disease, and frontal and ethmoid sinus infection.


Epithelioid Schwannoma

A schwannoma characterized by the presence of epithelioid cells with eosinophilic cytoplasm, within a myxoid and/or hyalinized stroma.


cardenolide

A steroid lactone that is a C23 steroid with methyl groups at C-10 and C-13 and a butenolide ring at C-17.


cardenolide glycoside

Any member of the class of cardenolides with glycosyl residues attached to position 3.


Grade 2 Vaginal Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Adult Diffuse Midline Glioma, H3 K27-Altered

A rare diffuse midline glioma, H3 K27-altered that occurs during adulthood.


Metastatic Adult Malignant Neoplasm in the Brain

A malignant neoplasm that has spread from its original site of growth to the brain in an adult patient.


Adult Brain Glioblastoma

A brain glioblastoma that occurs during adulthood.


Recurrent Childhood Glioblastoma

The reemergence of glioblastoma in childhood after a period of remission.


Recurrent WHO Grade 4 Glioma

The reemergence of WHO grade 4 glioma after a period of remission.


Recurrent Supratentorial Glioblastoma

The reemergence of supratentorial glioblastoma after a period of remission.


Recurrent Glioblastoma

The reemergence of glioblastoma after a period of remission.


Recurrent Childhood Gliosarcoma

The reemergence of gliosarcoma in childhood after a period of remission.


Recurrent Glioblastoma, IDH-Wildtype

The reemergence of glioblastoma, IDH-wildtype after a period of remission.


Recurrent MGMT-Methylated Glioblastoma

The reemergence of MGMT-methylated glioblastoma after a period of remission.


Recurrent Childhood Giant Cell Glioblastoma

The reemergence of giant cell glioblastoma in childhood after a period of remission.


Recurrent Small Cell Glioblastoma

The reemergence of small cell glioblastoma after a period of remission.


Recurrent Giant Cell Glioblastoma

The reemergence of giant cell glioblastoma after a period of remission.


Recurrent Gliosarcoma

The reemergence of gliosarcoma after a period of remission.


Recurrent Astrocytoma, IDH-Mutant, Grade 4

The reemergence of astrocytoma, IDH-mutant, Grade 4, after a period of remission.


Recurrent Diffuse Midline Glioma, H3 K27M-Mutant

The reemergence of diffuse midline glioma, H3 K27M mutant, after a period of remission.


Recurrent Brain Glioblastoma

The reemergence of brain glioblastoma after a period of remission.


Congenital anomaly of the urinary tract proper

An abnormality of the kidney, ureter, bladder, or urethra that is present at birth. Representative examples include renal hypoplasia, renal agenesis, accessory kidney, absence of ureter, atresia of bladder neck, and atresia of urethra.


Urachal remnant

Remaining collapsed and obliterated urachal tissue between the bladder dome and umbilicus.


Posterior Urethral Valves Type 1

A posterior urethral valve extending from the vera montanum towards the distal meatus.


Posterior Urethral Valves Type 3

A posterior urethral valve, presumed to result from incomplete canalization of the urethra, that is located immediately distal to the vera montanum.


Congenital Renal Hypoplasia

The underdevelopment of otherwise normal renal parenchyma, characterized by decreased nephron size and possibly a decreased number of nephrons at birth.


Prostatic Duct Urothelial Carcinoma

An urothelial carcinoma that arises from the urothelial lining of the prostatic ducts.


Ann Arbor Stage II Supradiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


large cell neuroendocrine carcinoma of kidney

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the kidney.  It is characterized by the presence of malignant large cells.


Solitary mass

A single isolated mass.


Squamous cell carcinoma of the oral cavity stage I

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage I Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage I includes: T1, N0, M0. T1: Tumor 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 5 Hyperglycemia, CTCAE

Death


Grade 4 Infections and Infestations - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Rectum Intra-Operative Injury, CTCAE


Childhood Bone Osteosarcoma

An osteosarcoma that arises from the bone and occurs during childhood.


Refractory Childhood Osteosarcoma

Childhood osteosarcoma that is resistant to treatment.


(R)-thalidomide

A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre.


Benign Extrahepatic Bile Duct Non-Epithelial Neoplasm

A neoplasm that arises from the non-epithelial tissues of the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Extrahepatic Bile Duct Fibroma

A benign neoplasm arising from the extra hepatic bile duct. It is characterized by the presence of spindle-shaped fibroblasts.


Benign Extrahepatic Bile Duct Soft Tissue Neoplasm

A mesenchymal neoplasm that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Extrahepatic Bile Duct Benign Granular Cell Tumor

A granular cell tumor that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Pigmented epithelioid melanocytoma

A cutaneous melanocytic neoplasm composed of heavily pigmented epithelioid and dendritic cells, with metastatic potential limited to regional lymph nodes. It can occur as a sporadic lesion or in patients with Carney complex. (WHO 2018)


Grade 3 or 4 Elevation of AST, ALT, and/or Bilirubin

A finding of grade 3 or 4 AST, Grade 3 or 4 ALT, and/or grade 3 or 4 bilirubin.


Grade 3 Sinus Bradycardia, CTCAE

Symptomatic, intervention indicated


Sinus Bradycardia, CTCAE

A disorder characterized by a dysrhythmia with a heart rate less than 60 beats per minute that originates in the sinus node.


Grade 1 Sinus Bradycardia, CTCAE

Asymptomatic, intervention not indicated


Grade 2 Sinus Bradycardia, CTCAE

Symptomatic, intervention not indicated; change in medication initiated


Grade 5 Sinus Bradycardia, CTCAE

Death


follicular dendritic cell sarcoma of thyroid gland

A rare follicular dendritic cell sarcoma involving the thyroid gland. It may be associated with chronic lymphocytic thyroiditis.


Acquired hallux valgus

A non-congenital deformity characterized by lateral deviation of the great toe.


Moderate Bronchopulmonary Dysplasia

A chronic lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates exposed to supplemental oxygen for at least 28 days. For infants born before 32 weeks gestation with moderate BPD, there is a supplemental oxygen requirement of less than 30% at 36 weeks postmenstrual age or earlier discharge. For infants born after 32 weeks with moderate BPD, there is a supplemental oxygen requirement of less than 30% at 56 days post-natal age or at earlier discharge.


Kidney Lymphangioma

A rare lymphangioma arising from the kidney.


Prostate Hemangioma

A rare hemangioma that arises from the prostate gland.


Vulvar Congenital Melanocytic Nevus

A benign nevus that arises from the vulva and is present at birth.


Congenital small melanocytic nevus

A congenital nevus of small size, with a diameter smaller than 1.5 cm. It presents as a macular, papular or plaque-like lesion.


Proliferative dermal lesion in congenital nevus

A benign proliferation of epithelioid or spindled melanocytes usually in the upper or mid dermis in a background of congenital melanocytic nevus. The congenital melanocytic nevus is usually of the deep type, involving the dermis and extending into the subcutaneous tissue. It presents as a dark plaque or nodule above a giant congenital melanocytic nevus.


Central Nervous System Solitary Fibrous Tumor, Grade 1

A solitary fibrous tumor that arises from the central nervous system. It corresponds most often to the collagenous and low cellularity spindle cell tumor which was diagnosed as central nervous system solitary fibrous tumor in the past.


Stomach Mass

An abnormal growth located in the stomach.


Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Duodenum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Refractory Fungal Infection

A fungal infection that is resistant to treatment.


Renal Benign Mesenchymoma

A benign mesenchymoma arising from the kidney.


Mild Bronchopulmonary Dysplasia

A chronic lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates exposed to supplemental oxygen for at least 28 days. For infants born before 32 weeks gestation with mild BPD, there is no supplemental oxygen requirement at 36 weeks postmenstrual age or earlier discharge. For infants born after 32 weeks with mild BPD, there is no supplemental oxygen requirement at 56 days post-natal age or at earlier discharge.


H influenze type B Pneumonia

Pneumonia that is attributed to the bacteria H influenze type B.


Collapsed Lung

Atelectasis of an entire lung.


Somatoform autonomic dysfunction - respiratory tract

A respiratory malfunction for which mental factors play a causative role.


Acute pneumonia

Acute inflammation of the lung parenchyma caused by viruses, bacteria, fungi, radiation treatment, or exposure to chemicals.  Signs and symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness.


Non-Neoplastic Lung Disorder

A lung disorder not caused by a neoplasm. Representative examples include chronic obstructive pulmonary disease, atelectasis, lung infections, pulmonary fibrosis, and pneumoconiosis.


Follicular Bronchitis/Bronchiolitis

A non-neoplastic disorder characterized by the formation of reactive lymphoid follicles adjacent to distal bronchi and bronchioles.  It presents with mild shortness of breath and is associated with immunodeficiency syndromes and collagen vascular disorders.


COVID-19-Associated Pneumonia

Pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is characterized by the presence of ground glass opacities on CT scan images.


Congenital anomaly of lung

A malformation in the lung that is present at birth. Representative examples include pulmonary hypoplasia, pulmonary agenesis, congenital lobar emphysema, and alveolar capillary dysplasia.


Pulmonary alveolitis

Inflammation of the alveoli of the lung.


Respiratory Failure Related to Neuromuscular Disorder

Impaired gas exchange by the respiratory system resulting in hypoxemia and decreased oxygenation of the tissues that may be associated with increased arterial levels of carbon dioxide; the respiratory failure is due to a neuromuscular disorder.


Paracicatricial Emphysema

The development of dilated terminal airspaces in the lung adjacent to parenchymal scarring.


Chronic obstructive asthma (with obstructive pulmonary disease)

Chronic airway obstruction caused by asthma.


Steroid-Refractory Pneumonitis

Pneumonitis that does not respond to corticosteroid therapy.


Tuberculous bronchiectasis

Bronchiectasis that develops in patients with a history of pulmonary tuberculosis.  It is usually associated with healed scars but occasionally may be seen in patients with active pulmonary tuberculosis.


Severe acute respiratory infection

A respiratory infectious disorder that leads to an acute illness that requires medical attention.


Stannosis

A disorder associated with chronic exposure to inhaled tin oxide dust or fumes.


Severe Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia that results in severe respiratory complications. The infants with severe symptoms are usually premature, have low birth weight, and the oxygen and ventilation support requirements are increased.


Pneumonia due to methicillin resistant Staphylococcus aureus

Pneumonia that is caused by Staphylococcus aureus that is resistant to methicillin treatment.


Cannabinosis

A disorder associated with chronic exposure to inhaled dust during the processing of hemp.


Asbestos-Related Lung Disorder

A disorder affecting the lungs due to asbestos exposure. Examples include asbestosis and lung carcinoma.


Toxoplasma Pneumonia

Pneumonia caused by the parasite Toxoplasma gondii.  It usually presents as an opportunistic infection in immunocompromised patients, especially patients with AIDS.  It is rare in immunocompetent individuals.  Signs and symptoms include cough, fever, and dyspnea.


Secondary Pneumonia

A pneumonia that occurs during or following treatment for an acute (primary) pneumonia that was caused by a different organism. It may be the result of increased susceptibility due to the initial treatment.


Pulmonary trunk hypoplasia

Underdeveloped pulmonary arteries.


Respiratory Failure Related to Central Nervous System Disorder

Impaired gas exchange by the respiratory system resulting in hypoxemia and decreased oxygenation of the tissues that may be associated with increased arterial levels of carbon dioxide; the respiratory failure is due to a central nervous system disorder.


Sickle Cell Chronic Lung Disease

A pulmonary complication of sickle cell disease characterized by radiographic interstitial abnormalities and impaired pulmonary function. In severe cases, pulmonary hypertension is present.


Hyaline Membrane Syndrome

A serious disorder affecting newborns, particularly premature infants. It is caused by deficiency of surfactant, resulting in the formation of a membrane in the alveoli lining. This membrane contains fibrin and cellular debris and interferes with respiration. Infants with this disorder develop breathing problems immediately or in a few hours after delivery. It may lead to respiratory failure.


Fibrotic Hypersensitivity Pneumonitis

Interstitial lung fibrosis resulting from chronic hypersensitivity pneumonitis.


AIDS-Related Pneumocystis Pneumonia

A serious AIDS-related opportunistic infection of the lungs, caused by Pneumocystis jirovecii.  It is one of the most common AIDS-related illnesses and is a major cause of morbidity in patients with AIDS.  Signs and symptoms include cough, fever, dyspnea, and pain or tightness in the chest.


Pulmonary Precancerous Condition

A premalignant pathologic process that affects the lungs.  This category includes bronchial intraepithelial neoplasia and atypical adenomatous hyperplasia.


Grade 4 Venous Injury, CTCAE

Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


Mesothelial hyperplasia

A hyperplasia of the mesothelial cells.


Atypical Mesothelial Hyperplasia

An atypical hyperplasia of the mesothelial cells.


Infectious Salpingitis

An acute or chronic infectious process affecting the fallopian tube. Chlamydia trachomatis, Neisseria gonorrhea, Mycoplasma, Staphylococcus, and Streptococcus are the most common causative agents.


mitomycin

A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.


onium betaine

Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


O-acetylcarnitine

An O-acylcarnitine having acetyl as the acyl substituent.


saturated fatty acyl-L-carnitine

An O-acylcarnitine in which the R is a saturated fatty acyl chain.


thiamine(1+) diphosphate(1-)

An ammonium betaine that is the conjugate base of thiamine(1+) diphosphate arising from the deprotonation of one of the hydroxy groups of the terminal phosphate group.


O-acylcarnitine

Any carboxylic ester obtained by the O-acylation of carnitine.


thiaminium carboxylate betaine

An ammonium betaine that is the conjugate base of thiamine(1+) carboxylic acid arising from the deprotonation of the carboxy group.


amino-acid betaine

Any amino acid-derived zwitterion - such as glycine betaine (N,N,N-trimethylammonioacetate) - in which the ammonium nitrogen carries methyl substituents and bears no hydrogen atoms.


fatty acyl-L-carnitine

Any O-acylcarnitine in which the carnitine component has L-configuration and the acyl group is a fatty acid.


carnitine

An amino-acid betaine that is butanoate substituted with a hydroxy group at position C-3 and a trimethylammonium group at C-4.


thiamine(1+) triphosphate(1-)

An ammonium betaine that is the conjugate base of thiamine(1+) triphosphate arising from the deptoronation of one of the hydroxy groups of the terminal phosphate group.


thiamine(1+) monophosphate(1-)

An ammonium betaine that is the conjugate base of thiamine(1+) monophosphate arising from the deprotonation of one of the phosphate hydroxy groups.


O-acyl-L-carnitine

An O-acylcarnitine in which the carnitine component has L-configuration.


sulfonium betaine

Neutral molecules having charge-separated forms with an sulfonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


ammonium betaine

Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


Grade 4 Intra-Abdominal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Rectal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Rectal Hemorrhage, CTCAE

A disorder characterized by bleeding from the rectal wall and discharged from the anus.


Grade 1 Rectal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 5 Rectal Hemorrhage, CTCAE

Death


Grade 2 Rectal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Stage IA Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

pT1, N0, M0, S0. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Immature Teratoma

An immature teratoma occurring in children.


Localized Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Tumor confined to the testes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Choriocarcinoma

A choriocarcinoma occurring in children.


Stage III Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Any pT, Any N, M1, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Testicular Yolk Sac Tumor, Prepubertal-Type

Testicular yolk sac tumor that almost always occurs in pure form and is not associated with germ cell neoplasia in situ. It affects young children and is the most frequently seen testicular neoplasm in prepubertal children.


Childhood Mature Teratoma

A mature teratoma occurring in children.


Refractory Childhood Malignant Germ Cell Tumor

A malignant germ cell tumor that occurs during childhood and is resistant to treatment.


Stage IIIC Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Any pT, N1-N3, M0, S3 or Any pT, Any N, M1, S3. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIIB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Any pT, N1-N3, M0, S2 or Any pT, Any N, M1, S2. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Malignant Testicular Germ Cell Tumor

A malignant germ cell tumor in children arising from the testis.  It includes the embryonal carcinoma, yolk sac tumor, choriocarcinoma, and mixed germ cell tumors.


Recurrent Childhood Malignant Germ Cell Tumor

The reemergence of a malignant germ cell tumor in children after a period of remission.


Stage IB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

pT2-4, N0, M0, S0. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Germinomatous Germ Cell Tumor

A germinomatous germ cell tumor occurring in children.


Childhood Mixed Germ Cell Tumor

A mixed germ cell tumor occurring in children.


Stage IIA Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Any pT, N1, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage II Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Any pT, N1-3, M0, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Extracranial Germ Cell Tumor

A childhood benign or malignant germ cell tumor arising from an anatomic site other than the brain.


Metastatic Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Teratoma

A mature or immature teratoma occurring in children.


Childhood Seminoma

A seminoma occurring in children.


Childhood Embryonal Carcinoma

An embryonal carcinoma occurring in children.


Childhood Extragonadal Teratoma

An extragonadal teratoma that occurs during childhood.


Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage, Tier 2

A term that refers to the staging of childhood testicular germ cell tumor according to the tier 2 Toronto childhood cancer staging guidelines v2.


Regional Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Tumor extension to regional lymph nodes: interaortocaval, para-aortic (periaortic), paracaval, preaortic, precaval, retroaortic, retrocaval, and along spermatic cord. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Any pT, N2, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Extragonadal Malignant Germ Cell Tumor

A malignant germ cell tumor in children arising from an anatomic site other than the testis or ovary.


Childhood Central Nervous System Teratoma

A mature or immature teratoma affecting the central nervous system and occurring in children.


Childhood Benign Germ Cell Tumor

A germ cell tumor that occurs during childhood and is characterized by the absence of atypia and metastatic potential.


Childhood Nongerminomatous Germ Cell Tumor

A nongerminomatous germ cell tumor occurring in children.


Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage, Tier 1

A term that refers to the staging of childhood testicular germ cell tumor according to the tier 1 Toronto childhood cancer staging guidelines v2.


Childhood Testicular Non-Seminomatous Germ Cell Tumor

A non-seminomatous germ cell tumor that arises in the testis and occurs in children.


Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage

A term that refers to the staging of childhood testicular germ cell tumor according to the Toronto childhood cancer staging guidelines v2.


Stage IS Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Any pT, N0, M0, S1-3. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage I Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

pT1-4, N0, M0, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIC Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

Any pT, N3, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Testicular Yolk Sac Tumor

A yolk sac tumor that arises from the testis during childhood.


Primary Cutaneous Amyloidosis

Amyloidosis that arises and remains localized in the skin. There are three main forms of primary cutaneous amyloidosis: lichen amyloidosis presenting with multiple itchy, raised, scaly red/brown spots; macular amyloidosis presenting with itchy, flat, brown or grey spots that form patches of darkened skin; and nodular amyloidosis presenting with brown or red nodules.


Intermediate Grade Osteosarcoma

An osteosarcoma with intermediate-grade morphological features. A representative example is periosteal osteosarcoma.


Peripheral Nervous System Infectious Disorder

An infectious process affecting the peripheral nerves.


Grade 5 Renal Calculi, CTCAE

Death


B-Cell Malignant Neoplasm

A clonal lymphoproliferative disorder composed of neoplastic B-cells. It includes B-cell non-Hodgkin lymphomas, B-cell leukemias, and plasma cell myeloma.


Chronic lymphocytic leukemia stage 1

Risk: Intermediate; Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


Multiple Myeloma with MAF Family Translocation

Multiple myeloma characterized by the presence of a translocation involving a MAF family gene.


DS Stage IA Plasma Cell Myeloma

Durie/Salmon stage I multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


B Acute Lymphoblastic Leukemia with t(4;11)(q21;23)

A B-cell acute lymphoblastic leukemia associated with t(4;11)(q21;23.3). This translocation leads to the generation of the fusion gene KMT2A-AFF1.


Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

A B acute lymphoblastic leukemia that occurs during childhood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


Hypodiploid B Acute Lymphoblastic Leukemia

A B-cell acute leukemia characterized by the presence of lymphoblasts which contain less than 46 chromosomes. It occurs in both children and adults. It has an unfavorable clinical outcome.


Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Chronic lymphocytic leukemia/small lymphocytic lymphoma that does not respond to treatment.


Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

The reemergence of chronic lymphocytic leukemia/small lymphocytic lymphoma after a period of remission.


Refractory B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

B-acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 that is resistant to treatment.


Leptomeningeal myelomatosis

A central nervous system multiple myeloma involving the leptomeninges.


B Acute Lymphoblastic Leukemia with Recurrent Genetic Abnormalities

B-acute lymphoblastic leukemias characterized by the presence of recurring cytogenetic and/or molecular abnormalities.


Refractory B Acute Lymphoblastic Leukemia

B-acute lymphoblastic leukemia that does not respond to treatment.


DS Stage IIIB Plasma Cell Myeloma

Durie/Salmon stage III multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


Recurrent B Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features

The reemergence of  B-acute lymphoblastic leukemia, BCR-ABL1-like after a period of remission.


B Acute Lymphoblastic Leukemia with ETV6-RUNX1-Like Features

B acute lymphoblastic leukemia characterized by a gene-expression profile similar to that of ETV6-RUNX1-positive B acute lymphoblastic leukemia, absence of the pathognomonic ETV6-RUNX1 rearrangement, and rearrangements or deletions of ETV6 and IKZF1 genes.


Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder

A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed B-lymphocytes or plasma cells. The clonal cellular infiltrates fulfill the criteria for a diffuse large B-cell lymphoma, Burkitt lymphoma, or a plasma cell neoplasm.


Recurrent B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

The reemergence of B acute lymphoblastic leukemia, Philadelphia chromosome negative, after a period of remission.


Multiple Myeloma, Not Otherwise Specified

Multiple myelomas characterized by the absence of recurrent genetic abnormalities.


B Acute Lymphoblastic Leukemia, Not Otherwise Specified

B-acute lymphoblastic leukemias characterized by the absence of recurrent genetic abnormalities.


Extramedullary Disease in Plasma Cell Myeloma Involving the Central Nervous System

Multiple myeloma involving the central nervous system. It manifests with single or multiple intraparenchymal lesions and/or leptomeningeal involvement. Patients present with diffuse cerebral dysfunction and nerve paralysis. The prognosis is poor.


Stage A Chronic Lymphocytic Leukemia

Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

Chronic lymphocytic leukemia characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


B Acute Lymphoblastic Leukemia with Mutated ZEB2 (p.H1038R)

B-acute lymphoblastic leukemia associated with mutations in the ZEB2 gene that encode a histidine to arginine amino acid substitution at codon 1038. This variation appears to phenocopy the IGH-CEBPE gene fusion. This is a provisional entity.


Refractory B-Cell Prolymphocytic Leukemia

B-cell prolymphocytic leukemia that is resistant to treatment.


Chronic Lymphocytic Leukemia- Binet Staging System

A term that refers to the staging of chronic lymphocytic leukemia according to Binet staging system. This system is in wide use outside the United States.


Chronic lymphocytic leukemia stage 4

Risk: High; Findings: Lymphocytosis and platelets less than 100,000/microliter; Survival (months): 30. (from AJCC 8th Ed.)


Cutaneous B Lymphoblastic Leukemia/Lymphoma

B-lymphoblastic leukemia/lymphoma that arises from the skin.


Recurrent Extraosseous Plasmacytoma

The reemergence of extraosseous plasmacytoma after a period of remission.


Recurrent Solitary Plasmacytoma

The reemergence of solitary plasmacytoma after a period of remission.


Stage B Chronic Lymphocytic Leukemia

Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


Plasma Cell Myeloma Post-Transplant Lymphoproliferative Disorder

A lymphoproliferative disorder that develops following an organ transplantation and exhibits multiple myeloma features.


Multiple Myeloma with Recurrent Genetic Abnormalities

Multiple myelomas characterized by the presence of recurring cytogenetic abnormalities.


Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorder

A plasmacytoma-like hematologic malignancy that arises in a patient with a history of organ transplantation.


B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 with Multilineage Involvement

B-acute lymphoblastic leukemia associated with t(9;22)(q34.1;q11.2); BCR-ABL1 and characterized by both lymphoblastic and differentiating myeloid cell proliferation.


B Acute Lymphoblastic Leukemia with Germline IKZF1 Mutation

B-acute lymphoblastic leukemia that results from germline mutation of the IKZF1 gene.


Chronic lymphocytic leukemia stage 2

Risk: Intermediate; Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


Adult B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

A B acute lymphoblastic leukemia that occurs during adulthood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


Multiple Myeloma with CCND Family Translocation

Multiple myeloma characterized by the presence of a translocation involving a CCND family gene.


RISS Stage I Plasma Cell Myeloma

Serum beta-2-microglobulin less than 3.5 mg/L and serum albumin 3.5 g/dL or more and no high-risk cytogenetics and normal LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


DS Stage IIB Plasma Cell Myeloma

Durie/Salmon stage II multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation

A chronic lymphocytic leukemia characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology.


Near-Haploid B Acute Lymphoblastic Leukemia

B-acute lymphoblastic leukemia associated with a near haploid karyotype.


B Acute Lymphoblastic Leukemia with IKZF1 N159Y Mutation

B-acute lymphoblastic leukemia associated with IKZF1 missense mutation p.Asn159Tyr (N159Y).


B Acute Lymphoblastic Leukemia with UBTF-ATXN7L3/PAN3, CDX2 ("CDX2/UBTF")

B-acute lymphoblastic leukemia associated with concomitant CDX2 deregulation and expression of the chimeric UBTF-ATXN7L3 fusion oncoprotein. It usually affects female adolescents and young adults. The prognosis is poor following treatment with conventional chemotherapy.


B acute lymphoblastic leukemia with DUX4 rearrangement

B-acute lymphoblastic leukemia associated with DUX4 gene rearrangement. The prognosis is good.


Extramedullary Disease in Plasma Cell Myeloma

Infiltration of organs and soft tissues by malignant (clonal) plasma cells in patients with history of multiple myeloma. Skin, liver, lymph nodes, pleura, and central nervous system are the most frequently affected sites.


Sinonasal Plasmacytoma

A plasmacytoma that arises in the sinonasal tract.


DS Stage IIA Plasma Cell Myeloma

Durie/Salmon stage II multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


Progressive Hairy Cell Leukemia Initial Treatment

A hairy cell leukemia requiring initial treatment because of the presence of signs of progression.  Signs of progression include cytopenia (especially if symptomatic), increasing splenomegaly, and infectious complications.  Therapy is not necessary if the patients are asymptomatic and the blood counts are maintained in an acceptable range.


Refractory Transformed Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia which has undergone histologic transformation to an aggressive diffuse large B-cell lymphoma (Richter's transformation) and has become resistant to treatment.


B Lymphoblastic Leukemia/Lymphoma with MYC Rearrangement

B-lymphoblastic leukemia/lymphoma associated with MYC gene rearrangement. The prognosis is poor.


Primary cutaneous plasmacytoma

A plasmacytoma that arises in the skin.


B Acute Lymphoblastic Leukemia with PAX5 Alteration

B-acute lymphoblastic leukemia associated with PAX5 gene alteration, including rearrangements, point mutations, and intragenic lesions. This is a provisional entity.


B Lymphoblastic Leukemia/Lymphoma with TCF3-HLF Rearrangement

An exceptionally rare childhood B-lymphoblastic leukemia/lymphoma associated with TCF3-HLF gene rearrangement resulting in the formation of TCF3-HLF chimeric transcription factor. The prognosis is poor.


B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, JAK-STAT Activated

B-acute lymphoblastic leukemia, BCR-ABL1-like associated with aberrant activation of the JAK-STAT signaling pathway.


Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

Chronic lymphocytic leukemia characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.


Testicular Plasmacytoma

A rare plasmacytoma that arises in the testis. At presentation the involvement is usually unilateral.


B Acute Lymphoblastic Leukemia with Germline PAX5 Mutation

B-acute lymphoblastic leukemia that results from germline mutation of the PAX5 gene.


DS Stage II Plasma Cell Myeloma

Multiple myeloma that fits in neither stage I nor stage III.  Estimated myeloma cell mass: 0.6 to 1.2 trillion (1012)/m2 (intermediate burden).  The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL.  Impaired renal function worsens prognosis regardless of stage.  Note that the newer International Staging System defines stage II quite differently: Beta-2-microglobulin less than 3.5 and albumin less than 3.5 or beta-2-microglobulin 3.5 to less than 5.5 (median survival of 44 months).  (PDQ)


B Acute Lymphoblastic Leukemia with MEF2D Rearrangement

B-acute lymphoblastic leukemia associated with MEF2D gene rearrangement. The prognosis is poor.


Chronic lymphocytic leukemia refractory

Chronic lymphocytic leukemia that is resistant to treatment.


Recurrent B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

The reemergence of B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 after a period of remission.


Extramedullary Disease in Plasma Cell Myeloma Involving the Uterine Corpus

Infiltration of the uterine corpus by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Childhood B Lymphoblastic Leukemia/Lymphoma

B lymphoblastic leukemia/lymphoma that occurs during childhood.


Multiple Myeloma with t(11;14)(q13;q32)

Multiple myeloma characterized by the presence of t(11;14)(q13;q32). It is the most common immunoglobulin heavy chain translocation found in multiple myeloma and results in CCND1 overexpression.


B Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features

B acute lymphoblastic leukemia characterized by a gene-expression profile similar to that of BCR-ABL1-positive B acute lymphoblastic leukemia, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome.


B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, ABL1 Rearranged

B-acute lymphoblastic leukemia, BCR-ABL1-like associated with ABL1 gene rearrangement.


Chronic Lymphocytic Leukemia- Modified Rai Staging System

A term that refers to the staging of chronic lymphocytic leukemia according to modified Rai staging system. This system is mainly used in North America.


Chronic lymphocytic leukemia stage 3

Risk: High; Findings: Lymphocytosis and hemoglobin less than 11 g/dL; Survival (months): 30. (from AJCC 8th Ed.)


RISS Stage II Plasma Cell Myeloma

Not stage I or III. (from AJCC 8th Ed.)


Low-Hypodiploid B Acute Lymphoblastic Leukemia

B-acute lymphoblastic leukemia associated with a low hypodiploid karyotype.


Plasma Cell Myeloma by ISS Stage

A header term that refers to the staging of multiple myeloma according to the International Staging System.


Recurrent Burkitt Leukemia

The reemergence of Burkitt leukemia after a period of remission.


Plasma Cell Post-Transplant Lymphoproliferative Disorder

A plasma cell neoplasm that arises in a patient with a history of organ transplantation.


Plasma Cell Myeloma by RISS Stage

A staging system for multiple myeloma based on the Revised International Staging System (RISS) criteria. This staging system does not apply to smoldering multiple myeloma (no AJCC staging system), monoclonal gammopathy of undetermined significance (no AJCC staging system), and Waldenstrom macroglobulinemia (no AJCC staging system). (from AJCC 8th Ed.)


B Acute Lymphoblastic Leukemia with Germline Predisposition

B-acute lymphoblastic leukemia that results from germline gene mutations. This category includes B-acute lymphoblastic leukemia with germline PAX5 mutation and B-acute lymphoblastic leukemia with germline IKZF1 mutation.


B acute lymphoblastic leukemia with PAX5 P80R mutation

B-acute lymphoblastic leukemia associated with PAX5 P80R mutation.


Adult Burkitt Leukemia

The leukemic counterpart of Burkitt lymphoma occurring in adults.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


ISS Stage II Plasma Cell Myeloma

Multiple myeloma with blood levels of beta-2-microglobulin between 3.5 and 5.5 mg/L.


Plasmacytoma anaplastic

A plasmacytoma characterized by the presence of malignant plasma cells with anaplastic features.


B Acute Lymphoblastic Leukemia with MYC Rearrangement

B-acute lymphoblastic leukemia associated with MYC gene rearrangement. The prognosis is poor.


Refractory Burkitt Leukemia

Burkitt leukemia resistant to treatment.


Advanced B-Cell Malignant Neoplasm

A B-cell malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Multiple Myeloma with NSD2 Translocation

Multiple myeloma characterized by the presence of a translocation involving the NSD2 gene.


Recurrent Transformed Chronic Lymphocytic Leukemia

The reemergence of chronic lymphocytic leukemia transformed to aggressive diffuse large B-cell lymphoma (Richter's transformation) after a period of remission.


Extramedullary Disease in Plasma Cell Myeloma Involving the Skin

Infiltration of the skin by malignant (clonal) plasma cells in patients with history of multiple myeloma.


B Acute Lymphoblastic Leukemia with ZNF384 Rearrangement

B-acute lymphoblastic leukemia associated with ZNF384 gene rearrangement. The prognosis is variable.


B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 with Lymphoid Only Involvement

B-acute lymphoblastic leukemia associated with t(9;22)(q34.1;q11.2); BCR-ABL1 and characterized by lymphoblastic proliferation without differentiating myeloid cell proliferation.


Stage C Chronic Lymphocytic Leukemia

Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


Cutaneous Chronic Lymphocytic Leukemia

A chronic lymphocytic leukemia that affects the skin.


DS Stage III Plasma Cell Myeloma

Multiple myeloma with one or more of the following: 1. Hemoglobin less than 8.5 g/dL. 2. Serum calcium greater than 12.0 mg/dL. 3. More than three lytic bone lesions. 4. High M protein production as shown by: a. IgG greater than 7.0 g/dL. b. IgA greater than 5.0 g/dL. c. Urinary kappa or lamda greater than 12.0 g/24 hours. Estimated myeloma cell mass: greater than 1.2 trillion (1012)/m2 (high burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL. b. Creatinine greater than or equal to 2.0 mg/dL. Serum beta-2-microglobulin has been shown to be a reliable marker for prognosis. Since the great majority of symptomatic myeloma patients are classified as stage III by the Durie/Salmon criteria, this staging system has not proven to be very useful for identifying the patients with intermediate and poor prognosis. Note that the newer International Staging System defines stage III quite differently: Beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months). (PDQ)


DS Stage I Plasma Cell Myeloma

Multiple myeloma with all of the following: 1. Hemoglobin greater than 10 g/Dl, 2. Normal serum calcium, 3. Normal bone structure, 4. Low monoclonal (or myeloma) protein (M protein) production as shown by: a. IgG less than 5.0 g/dL, b. IgA less than 3.0 g/dL, c. Urinary kappa or lamda less than 4 g/24 hours. Estimated myeloma cell mass: less than 0.6 trillion (1012)/m2 (low burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note that the newer International Staging System defines stage I quite differently: Beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months). (PDQ)


B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

A B-acute lymphoblastic leukemia (B-ALL) that does not have the cytogenetic abnormality t(9;22)(q34;q11.2). Most cases of B-ALL do not have this translocation.


DS Stage IIIA Plasma Cell Myeloma

Durie/Salmon stage III multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


B Lymphoblastic Leukemia/Lymphoma with ETV6-RUNX1-Like Features

B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of ETV6-RUNX1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic ETV6-RUNX1 rearrangement, and rearrangements or deletions of ETV6 and IKZF1 genes.


Recurrent B Acute Lymphoblastic Leukemia

The reemergence of B acute lymphoblastic leukemia after a period of remission.


RISS Stage III Plasma Cell Myeloma

Serum beta-2-microglobulin 5.5 mg/L or more and high-risk cytogenetics and/or high LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


B Acute Lymphoblastic Leukemia Associated with Down Syndrome

A B-acute lymphoblastic leukemia that occurs in patients with Down syndrome. It usually affects young children, but it can occur in adults as well. It has an unfavorable clinical outcome. Cases of T-acute lymphoblastic leukemia in patients with Down syndrome have not been reported.


Hyperdiploid B Acute Lymphoblastic Leukemia

A B-cell acute leukemia characterized by the presence of lymphoblasts which contain more than 50 and usually less than 66 chromosomes. It is commonly seen in children and rarely in adults. It has a favorable clinical outcome.


B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

B-lymphoblastic leukemias/lymphomas characterized by the absence of recurrent genetic abnormalities.


B Acute Lymphoblastic Leukemia with NUTM1 Rearrangement

B-acute lymphoblastic leukemia associated with NUTM1 gene rearrangement. The prognosis is good.


ISS Stage III Plasma Cell Myeloma

Multiple myeloma with beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months).  Note that the older Durie/Salmon staging system defines stage III quite differently. (PDQ)


DS Stage IB Plasma Cell Myeloma

Durie/Salmon stage I multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, ABL Class Rearranged

B-acute lymphoblastic leukemia, BCR-ABL1-like associated with rearrangement of an ABL class gene (e.g., ABL1, ABL2, CSF1R, PDGFRA, and PDGFRB).


Recurrent B-Cell Prolymphocytic Leukemia

The reemergence of a B-cell prolymphocytic leukemia after a period of remission.


Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma

Histologic transformation of an indolent chronic lymphocytic leukemia to an aggressive diffuse large B-cell lymphoma.


Extramedullary Disease in Plasma Cell Myeloma Involving the Kidney

Infiltration of the kidney by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Multiple Myeloma with Hyperdiploidy

Multiple myeloma characterized by the presence of plasma cells in which the chromosomal number is greater than the normal diploid number.


Chronic lymphocytic leukemia stage 0

Risk: Low; Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


Refractory B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

B acute lymphoblastic leukemia, Philadelphia chromosome negative, that does not respond to treatment.


B Acute Lymphoblastic Leukemia with ZNF362 Rearrangement

B-acute lymphoblastic leukemia associated with ZNF362 gene rearrangement. The prognosis is variable.


Refractory B Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features

B-acute lymphoblastic leukemia, BCR-ABL1-like that does not respond to treatment.


ISS Stage I Plasma Cell Myeloma

Multiple myeloma with beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months).  Note that the older Durie/Salmon staging system defines stage I quite differently. (PDQ)


B-lymphoblastic leukemia lymphoma BCR-ABL1-like

B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of BCR-ABL1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome.


B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, Not Otherwise Specified

B-acute lymphoblastic leukemia, BCR-ABL1-like in which further genetic/molecular characterization is not available.


Plasma Cell Myeloma by DS Stage

A header term that refers to the staging of multiple myeloma according to the Durie/Salmon staging system.


Childhood Burkitt Leukemia

The leukemic counterpart of Burkitt lymphoma occurring in children.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


Penile Undifferentiated Pleomorphic Sarcoma

A rare undifferentiated pleomorphic sarcoma that occurs in the penis.


Grade 1 Scrotum Intra-Operative Injury, CTCAE


Non-Neoplastic Vision Disorder

A non-neoplastic disorder that causes a disturbance in normal vision. Representative examples include amblyopia, astigmatism, myopia, and cataracts.


Color Blindness, Inherited

Genetic based difficulty in distinguishing colors.


Advanced Extracranial Malignant Solid Neoplasm

A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


Ciliary Body Adenocarcinoma

An adenocarcinoma arising from the pigmented or non-pigmented ciliary epithelium.


Stage IIB Uveal Melanoma AJCC v7

Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIA Uveal Melanoma AJCC v7

Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0). T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Metastatic Choroid Melanoma

Choroid melanoma that has spread from its primary site to another anatomic site.


Metastatic Malignant Neoplasm in the Uvea

A malignant neoplasm that has spread to the uvea from another anatomic site.


Uveal Melanocytoma

A subtype of ciliary body, iris, and choroidal nevi. It is intensely pigmented and composed of large, plump, polyhedral cells.


Choroid Spindle Cell Type A Melanoma

A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Uveal Melanoma by Gene Expression Profile


Locally Advanced Unresectable Uveal Melanoma

Uveal melanoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Uveal Spindle Cell Type A Melanoma

A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage III Uveal Melanoma AJCC v7

Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC (T4d-e, N0, M0).  T2c: Ciliary body and choroid: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T2d: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T3b: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement. T3c: Ciliary body and choroid: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T4a: Iris: Tumor with extrascleral extension less than or equal to 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 without ciliary body involvement and extraocular extension.  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Uveal Class 2 Melanoma

Gene expression profiling that classifies uveal melanomas into a high-grade group.


Uveal Class 1a Melanoma

Uveal melanoma with low metastatic risk as defined by gene expression profiling.


Ciliary Body Nevus

A benign nevus that arises from the ciliary body. Only a small percentage of cases progress to ciliary body melanoma.


Stage IIIC Uveal Melanoma AJCC v7

Stage IIIC includes: T4d-e, N0, M0.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Uveal Melanoma

Uveal melanoma that is resistant to treatment.


Choroidal Ganglioneuroma

A rare ganglioneuroma that arises from the choroid.


Choroidal and Ciliary Body Melanoma by AJCC v8 Stage

A term that refers to the staging of choroidal and ciliary body melanoma, following the rules of the TNM AJCC v8 classification system.


Stage IIB Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Choroid Spindle Cell Type B Melanoma

A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Stage IIIB Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0). T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Uveal Class 1b Melanoma

Uveal melanoma with intermediate metastatic risk as defined by gene expression profiling.


Ciliary Body Spindle Cell Type B Melanoma

A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Stage II Uveal Melanoma AJCC v7

Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Choroidal and Ciliary Body Melanoma AJCC v8

Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC: (T4d-e, N0, M0). T2c: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T2d: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T3b: Tumor size category 3 with ciliary body involvement. T3c: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4a: Tumor size category 4 without ciliary body involvement and extraocular extension. T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Stage I Uveal Melanoma AJCC v7

Stage I includes: T1a, N0, M0.  T1a: Iris: Tumor limited to the iris not more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIA Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Stage I Choroidal and Ciliary Body Melanoma AJCC v8

Stage I includes: T1a, N0, M0. T1a: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 8th ed.)


Stage IV Choroidal and Ciliary Body Melanoma AJCC v8

Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c). N1: Regional lymph node metastasis or discrete tumor deposits in the orbit. M0: No distant metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less. M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm. M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.1 cm or more.  (AJCC 8th ed.)


Ciliary Body Spindle Cell Type A Melanoma

A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage IIIB Uveal Melanoma AJCC v7

Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0).  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Iris Mixed Cell Melanoma

A melanoma arising from the iris. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells.


Stage IV Uveal Melanoma AJCC v7

Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c).  N1: Regional lymph node metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less.  M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm.  M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.0 cm or more.  (AJCC 7th ed.)


Benign neoplasm of uveal tract

A neoplasm that arises from the uvea and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential..


Stage IIIC Choroidal and Ciliary Body Melanoma AJCC v8

Stage IIIC includes: T4d-e, N0, M0. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Metastatic Malignant Neoplasm in the Iris

A malignant neoplasm that has spread to the iris from another anatomic site.


Stage II Choroidal and Ciliary Body Melanoma AJCC v8

Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Uveal Melanoma by AJCC v7 Stage

A term that refers to the staging of uveal melanoma, following the rules of the TNM AJCC v7 classification system.


Uveal Spindle Cell Type B Melanoma

A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Uveal Class 1 Melanoma

Gene expression profiling that classifies uveal melanomas into a low-grade group.


Uveal Nevus

A benign nevus derived from melanocytes of the uveal tract. Only a small percentage of cases progress to uveal melanoma.


Advanced Uveal Melanoma

Uveal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Iridociliary Melanoma

Melanoma that affects both the iris and ciliary body.


Iris Epithelioid Cell Melanoma

An iris melanoma characterized by the presence of malignant large epithelioid melanocytes.


Metastatic malignant neoplasm to ciliary body

A malignant neoplasm that has spread to the ciliary body from another anatomic site.


Conjunctival keratoacanthomas

A rapidly growing neoplasm that arises from the conjunctiva. It is characterized by a proliferation of squamous cells, acanthosis, keratinization, dysplasia, increased mitotic activity, and a central crater filled with keratinocytes. It is considered a variant of well-differentiated squamous cell carcinoma with distinct clinical behavior.


Conjunctival Spindle Cell Carcinoma

A variant of conjunctival squamous cell carcinoma characterized by the presence of malignant spindle cells and/or pleomorphic cells.


Stage II Fallopian Tube Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Fallopian Tube Cancer AJCC v8

Stage IIA includes: T2a, N0, M0. T2a: Fallopian tube cancer with extension and/or implants on the uterus and/or fallopian tube(s) and/or ovaries. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIB Fallopian Tube Cancer AJCC v8

Stage IIB includes: T2b, N0, M0. T2b: Fallopian tube cancer with tumor extension to and/or implants on other pelvic tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 5 Sepsis, CTCAE

Death


Sepsis, CTCAE

A disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause a rapidly progressing systemic reaction that may lead to shock.


Grade 4 Sepsis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Sepsis, CTCAE

Blood culture positive with signs or symptoms; treatment indicated


Grade 1 Hepatobiliary Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Laryngeal Paraganglioma

An extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to the larynx.  Patients may present with hoarseness and dysphagia.


Finding by Site or System

A term that refers to the classification of a clinical or laboratory finding according to the anatomic site or system that is involved.


Muscle Weakness Right-Sided

A reduction in the strength of the muscles in the right side of the body.


Congenital urinary tract obstruction

An impediment to the flow of urine along the urinary tract, which is present at birth.


Shakes

Unsteadiness or trembling movements of the whole body or a body part.


Right Bundle Branch Block by ECG Finding

An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the right ventricle, manifested by a widened initial portion of the QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration greater than or equal to 120 ms.  An RsR' complex is typically present in leads V1 and V2. (CDISC)


AV Block Second Degree Mobitz Type II by ECG Finding


Jejunal Obstruction

Blockage of the normal flow of the small intestinal contents in the jejunum.


Todd's Paralysis

A neurological condition experienced by individuals with epilepsy, in which a seizure is followed by a brief period of temporary paralysis.


Mild Cardiac Valve Stenosis

The cardiac valve orifice is abnormally narrow, to a mild degree. (ACC)


Fallopian tube obstruction

Blockage of the normal flow of the contents in the fallopian tube.


Carpal Spasm

A spasmodic contraction of the muscles of the hands, especially the wrists, such as during alkalosis or tetany. (ACC/AHA)


Pancreatic Duct Stenosis

Narrowing of the lumen of the pancreatic duct.


New daily persistent headache

A bilateral, unremitting headache of mild to moderate intensity that occurs daily and may be associated with photophobia, phonophobia, or mild nausea.


Pregnancy Finding

Symptoms, signs, diagnostic examinations or a test results in a pregnant mother.


Nausea and Vomiting During the First 24 Hours After Chemotherapy

Nausea and vomiting occurring during the first 24 hours following chemotherapy.


Aldosterone Synthase Deficiency Type 2

Aldosterone synthase deficiency characterized by decreased conversion of 18-hydroxycorticosterone to aldosterone.


AV Block Third Degree by ECG Finding

An electrocardiographic finding of complete failure of atrial electrical impulse conduction to the ventricles. This is manifested on the ECG by disassociation of atrial and ventricular rhythms. The atrial rate must be faster than the ventricular rate. (CDISC)


Lumbar Puncture Headache

Headache in erect position, after lumbar puncture; due to lowering of intracranial pressure by leakage of cerebrospinal fluid through the needle tract.


Hypotonic-hyporesponsive episode

Acute onset of unresponsiveness or diminished level of consciousness, associated with loss of muscle tone and pallor or cyanosis, that occurs within 48 hours after childhood immunizations. It is primarily associated with pertussis-containing vaccines administered to children under two years of age.


Subclavian vein stenosis

Narrowing of the lumen of the subclavian vein.


Obstruction of trachea

Blockage of the lumen of the trachea. Causes include secretions, foreign bodies, and tumors.


Damage of Vaginal Mucosa

Injury to vaginal mucosa.


Caries into Dentin

Tooth decay that extends through the enamel into the dentin layer.


Intrapartum Shock

Severe loss of blood pressure leading to inadequate tissue perfusion after the onset of labor but prior to the delivery of the fetus.


Brachial plexus palsy due to birth trauma

Birth injury to the brachial plexus. It results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm, usually in the first week of life. In the majority of cases there is spontaneous recovery.


Pedal Spasm

A spasmodic contraction of the muscles of the feet, especially the ankles, such as during alkalosis or tetany. (ACC/AHA)


Syncope due to Acquired Heart Lesion

A condition in which syncope occurs due to a disease process of the heart with which the patient was not born. (ACC/AHA)


Superficial injury of cornea

Trauma to the corneal epithelium.


Palsy

Muscle weakness or paralysis of neurologic origin.


Cardiac septal defect residual shunt

Irregular blood flow in the heart after surgical correction of a septal defect.


Shock, Traumatic

Any shock produced by trauma.


Psychogenic tremor

An involuntary, compulsive, repetitive stereotyped movement.


Infertility Related to Treatment

Infertility that is associated with a treatment.


Cardiogenic Shock Related to COVID-19

Cardiogenic shock in a patient with probable or confirmed acute COVID-19.