Stage 2 Neuroblastoma

Stage 2 includes stage 2A and stage 2B.  Stage 2A: Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph nodes negative for tumor microscopically. Stage 2B: Localized tumor with or without complete gross excision, with ipsilateral nonadherent lymph nodes positive for tumor. Enlarged contralateral lymph nodes must be negative microscopically. (cancer.gov)


Locally Advanced Chordoma

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A chordoma that has spread from its original site of growth to nearby tissues.


Regional Neuroblastoma

A neuroblastoma confined to a specific anatomic region without evidence of dissemination.


Stage M2 Medulloblastoma

Gross nodular seeding is detected in the cerebellar/cerebral subarachnoid space or in the third or lateral ventricles. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Extrarenal Rhabdoid Tumor of the Prostate

A rare extrarenal rhabdoid tumor affecting the prostate gland.


Stage M4 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

Metastasis outside of the central nervous system. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

A malignant small round cell tumor with or without neural differentiation that is resistant to treatment.


Unresectable Neuroblastoma

Neuroblastoma which is not amenable to surgical resection.


Stage 2A Neuroblastoma

Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph nodes negative for tumor microscopically. (cancer.gov)


Sinonasal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the nasal cavity and paranasal sinuses.


Medulloblastoma Molecular Subtypes

A term that refers to the classification of medulloblastomas according to their molecular characteristics.


Metastatic Neuroblastoma

A neuroblastoma that has metastasized from its original site of growth to another anatomic site.


Recurrent Childhood Medulloblastoma

The reemergence of childhood medulloblastoma after a period of remission.


Localized Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified

A supratentorial embryonal tumor, not otherwise specified that occurs in childhood.


Extra-osseous Ewing's sarcoma non-metastatic

Ewing sarcoma that arises from the soft tissue and is confined to a specific site without evidence of spread to other anatomic sites.


Medulloblastoma, Not Otherwise Specified

A medulloblastoma which has not been further characterized.


MS Childhood Neuroblastoma by Toronto Guidelines v2

Metastatic disease confined to skin, liver, and/or bone marrow in a patient less than 18 months (547 days). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage MS Childhood Neuroblastoma by Toronto Guidelines v2

Metastatic disease confined to skin, liver, and/or bone marrow, in a patient less than 18 months (547 days). MIBG scintigraphy must be negative in bone and bone marrow. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Benign medulloepithelioma of ciliary body

A rare, unilateral, benign embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium.


Recurrent tumors of the Ewing's family

The reemergence of a malignant small round cell tumor with or without neural differentiation after a period of remission.


Malignant medulloepithelioma of ciliary body

A rare, unilateral, malignant embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium.


Recurrent Primitive Neuroectodermal Tumor

The reemergence of a primitive neuroectodermal tumor of the central or the peripheral nervous system after a period of remission.


Anaplastic Kidney Wilms Tumor

Wilms tumor of the kidney characterized by the presence of nuclear anaplasia.  Anaplasia is defined by the presence of all of the following: multipolar polyploid mitotic figures, marked nuclear enlargement, and hyperchromasia.  When anaplasia is diffuse, it is associated with an unfavorable clinical outcome.


Disseminated neuroblastoma

Any primary tumor with dissemination to distant lymph nodes, bone, bone marrow, liver, skin, and/or other organs, except as defined for stage 4S. (cancer.gov)


Stage II Kidney Wilms Tumor

Wilms tumor that is found in the kidney and in the fat, soft tissue, or blood vessels near the kidney. It may have spread to the renal sinus. The renal sinus is the part of the kidney where blood and fluid enter and exit the organ. The tumor can be completely removed with surgery. (National Wilms Tumor Study Group Staging System)


Localized Askin Tumor

A small round cell tumor confined to a specific area of the thoracic cavity without evidence of spread to other anatomic sites.


Recurrent Kidney Wilms Tumor

The reemergence of Wilms tumor of the kidney after a period of remission.


Stage M4 Atypical Teratoid/Rhabdoid Tumor

Metastasis outside the cerebrospinal axis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Stage III Kidney Wilms Tumor

Wilms tumor that is found in areas near the kidney and cannot be completely removed with surgery. The tumor may have spread to nearby organs and blood vessels or throughout the abdomen and to nearby lymph nodes. Lymph nodes are tiny, bean-shaped organs that help fight infection. Stage III cancer has not spread outside the abdomen. (National Wilms Tumor Study Group Staging System)


Central Nervous System Embryonal Tumor with Rhabdoid Features

A central nervous system embryonal neoplasm characterized by the presence of histological features consistent with atypical teratoid/rhabdoid tumor and absence of mutations of the INI1 gene or SMARCA4 (BRG1) gene.


Central Nervous System Embryonal Tumor, Not Elsewhere Classified

A central nervous system embryonal tumor lacking molecular abnormalities that would classify it as one of the molecularly defined central nervous system embryonal neoplasms.


Stage M0 Medulloblastoma

No evidence of subarachnoid or hematogenous metastasis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Atypical Teratoid/Rhabdoid Tumor-MYC

Atypical teratoid/rhabdoid tumor characterized by overexpression of MYC gene.


Refractory Wilms Tumor

Wilms tumor that is resistant to treatment.


Metastatic Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

Disease beyond local site (e.g., other lesions in brain or spine or tumor cells in CSF or distant metastases). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Ganglioneuroblastoma, Nodular

A nodular ganglioneuroblastoma that occurs during childhood.


Unresectable Extrarenal Rhabdoid Tumor

Extrarenal rhabdoid tumor that is not amenable to surgical resection.


Stage M3 Medulloblastoma

Gross nodular seeding is detected in the spinal subarachnoid space. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Kadish Stage B Olfactory Neuroblastoma

An olfactory neuroblastoma that involves the nasal cavity and paranasal sinuses.


Fourth Ventricle Medulloblastoma

A medulloblastoma occurring in the fourth ventricle.


Localized Unresectable Neuroblastoma

Neuroblastoma that is confined to a specific site and is not amenable to surgical removal.


Stage M1 Childhood Medulloblastoma by Toronto Guidelines v2

Tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Kidney Ewing Sarcoma

A rare Ewing sarcoma arising from the kidney.


Kadish Stage A Olfactory Neuroblastoma

An olfactory neuroblastoma that is confined to the nasal cavity


Stage M3 Embryonal Tumor with Multilayered Rosettes


Metastatic Childhood Medulloblastoma by Toronto Guidelines v2


Benign Notochordal Cell Tumor

An intraosseous benign tumor of notochord origin that arises in the bones of the base of the skull, vertebral bodies, sacrum or coccyx.  It contains vacuolated tumor cells without atypia, but lacks myxoid matrix, necrosis, and lobular architecture, which are features that characterize its malignant counterpart, chordoma.  Most lesions are incidental findings.


Recurrent Extrarenal Rhabdoid Tumor

The reemergence of extrarenal rhabdoid tumor after a period of remission.


Central Nervous System Neuroblastoma, FOXR2-Activated

A rare central nervous system neoplasm with neuroblastic and/or neuronal differentiation. It is characterized by the presence of structural rearrangements of FOXR2 gene that result in the activation of the transcription factor FOXR2.


Refractory Primitive Neuroectodermal Tumor

Primitive neuroectodermal tumor that does not respond to treatment.


Metastatic Medulloblastoma

Medulloblastoma that has spread from its original site of growth to another anatomic site.


medulloblastoma non-WNT/non-SHH group 3

Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog (SHH) pathway. MYC amplifications may be present. TP53 mutations are absent. Patients in this group are usually young children. The overall survival is the worst among all the molecular groups.


Stage 1 Neuroblastoma

Localized tumor with complete gross excision, with or without microscopic residual disease; representative ipsilateral lymph nodes negative for tumor microscopically. (cancer.gov)


Vulvar Ewing Sarcoma

Ewing sarcoma arising from the vulva.


Central Nervous System Ewing Sarcoma

Ewing sarcoma that arises in the central nervous system.


Region 17p13 Allelic Loss Associated Medulloblastoma

A medulloblastoma characterized by the loss of one of the p13 regions of chromosome 17.  Loss of genetic material of chromosome arm 17p is the most common molecular genetic abnormality found in medulloblastomas.


Stage M0 Pineoblastoma

No evidence of subarachnoid or hematogenous metastasis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Recurrent Bone Ewing Sarcoma

The reemergence of Ewing sarcoma of the bone after a period of remission.


Stage M2 Pineoblastoma

Gross nodular seeding is detected in the cerebellar/cerebral subarachnoid space or in the third or lateral ventricles. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Stage M2 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

Visible metastasis in brain. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Extra-osseous Ewing's sarcoma metastatic

An Ewing sarcoma of the soft tissues which has spread from its original site of growth to another anatomic site.


Sinonasal Olfactory Neuroblastoma

An olfactory neuroblastoma that arises from the sinonasal tract.


Childhood Chordoma

A rare chordoma that occurs during childhood.


Childhood Kidney Ewing Sarcoma

An extremely rare Ewing sarcoma that arises from the kidney during childhood.


Childhood Pineoblastoma

A pineoblastoma that occurs during childhood.


Metastatic Chordoma

A chordoma that has spread from its original site of growth to other anatomic sites.


Stage M Childhood Neuroblastoma by Toronto Guidelines v2

Distant metastatic disease (i.e., not contiguous with the primary tumor) except as defined for stage MS. Nonregional (distant) lymph node involvement is metastatic disease. However, an upper abdominal tumor with enlarged lower mediastinal nodes or a pelvic tumor with inguinal lymph node involvement is considered locoregional disease. Ascites and/or a pleural effusion, even with malignant cells, do not constitute metastatic disease unless they are remote from the body compartment of the primary tumor. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Medulloblastoma, SHH-1

Medulloblastoma, SHH-activated, characterized by SUFU gene mutations and chromosome 2 gain. It affects mostly infants.


Stage I Kidney Wilms Tumor

Wilms tumor that is found in one kidney and can be completely removed with surgery. (National Wilms Tumor Study Group Staging System)


Dedifferentiated chordoma

A high-grade malignant bone tumor arising from the remnants of the notochord. It is characterized by a lobulated growth pattern, myxoid stroma formation, the presence of physaliphorous cells, and a sarcomatous component.


Recurrent Ganglioneuroblastoma

The reemergence of ganglioneuroblastoma after a period of remission.


The reemergence of SHH-activated medulloblastoma after a period of remission.


Childhood Central Nervous System Embryonal Neoplasm

A central nervous system embryonal tumor that occurs during childhood.


Peripheral Primitive Neuroectodermal Tumor of the Kidney

A small round cell tumor with neural differentiation arising from the kidney.


Recurrent Olfactory Neuroblastoma

The reemergence of olfactory neuroblastoma after a period of remission.


Childhood Ganglioneuroblastoma

A ganglioneuroblastoma that occurs during childhood.


Large cell Ewing sarcoma of bone

Ewing sarcoma characterized by the presence of large malignant cells with prominent nucleoli and irregular contours.


Medulloblastoma, SHH-3

Medulloblastoma, SHH-activated, characterized by mutations of TP53 and ELP1 genes. It affects older individuals.


Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2 Stage, Tier 1

A term that refers to the staging of childhood central nervous system embryonal tumor according to the tier 1 Toronto childhood cancer staging guidelines v2.


Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified

The reemergence of supratentorial embryonal tumor, not otherwise specified in childhood after a period of remission.


Stage M4 Pineoblastoma

Metastasis outside the cerebrospinal axis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


PNET of bone localised

A small round cell tumor with neural differentiation that is confined to a specific area of the bone and has not spread to other anatomic sites.


Embryonal Tumor with Multilayered Rosettes without C19MC Alteration

An embryonal tumor with multilayered rosettes characterized by the absence of C19MC amplification. Approximately half of embryonal tumors with multilayered rosettes that lack a C19MC alteration carry DICER1 mutations.


Kadish Stage C Olfactory Neuroblastoma

An olfactory neuroblastoma that extends beyond the nasal cavity and paranasal sinuses.


Nevoid Basal Cell Carcinoma Syndrome Associated Medulloblastoma

A medulloblastoma developing in patients with multiple basal cell carcinomas.  It is observed in patients with nevoid basal cell carcinoma syndrome and it is associated with PTCH gene inactivation.


Medulloblastoma, WNT-activated that is resistant to treatment.


Refractory Medulloblastoma

Medulloblastoma that does not respond to treatment.


Stage M2 Childhood Medulloblastoma by Toronto Guidelines v2

Visible metastasis in brain. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage M0 Embryonal Tumor with Multilayered Rosettes

No evidence of subarachnoid or hematogenous metastasis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Stage M4 Childhood Medulloblastoma by Toronto Guidelines v2

Metastasis outside of the central nervous system. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage 2B Neuroblastoma

Localized tumor with or without complete gross excision, with ipsilateral nonadherent lymph nodes positive for tumor. Enlarged contralateral lymph nodes must be negative microscopically. (cancer.gov)


Childhood Central Nervous System Neuroblastoma

A neuroblastoma that arises from the central nervous system and occurs during childhood.


SHH-activated medulloblastoma that does not respond to treatment.


Metastatic Bone Ewing Sarcoma

An Ewing sarcoma of the bone which has spread from its original site of growth to another anatomic site.


Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

A small round cell tumor with or without neural differentiation that has spread from its original site of growth to another anatomic site.


medulloblastoma non-WNT/non-SHH group 4

Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog (SHH) pathway. MYC amplifications are absent. TP53 mutations are absent. Chromosome 17 abnormalities may be present.


Stage M1 Medulloblastoma

Microscopic tumor cells are detected in the cerebrospinal fluid. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Metastatic Ewing's Sarcoma

Ewing sarcoma that has spread from its original site of growth to another anatomic site.


Refractory Ewing Sarcoma

Ewing sarcoma that does not respond to treatment.


Recurrent Peripheral Primitive Neuroectodermal Tumor

The reemergence of a small round cell tumor with neural differentiation after a period of remission.


ELP1-Associated Medulloblastoma

An SHH-activated, TP53-wildtype medulloblastoma caused by germline ELP1 gene variations and develops during childhood.


Stage M1 Atypical Teratoid/Rhabdoid Tumor


Locoregional Childhood Neuroblastoma by Toronto Guidelines v2

Locoregional tumor with spread. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Mesoblastic nephroma, mixed

A congenital mesoblastic nephroma characterized by the presence of classic and cellular areas.


Refractory Chordoma

A chordoma that does not respond to treatment.


Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2 Stage

A term that refers to the staging of childhood central nervous system embryonal tumor according to the Toronto childhood cancer staging guidelines v2.


Central Nervous System Ganglioneuroblastoma

A malignant central nervous system neoplasm characterized by the presence of poorly differentiated or undifferentiated neuroepithelial cells and ganglion cells.


Childhood Neuroblastoma

A neuroblastoma that occurs during childhood.


Ewing's sarcoma recurrent

Ewing sarcoma which has recurred after treatment and/or remission. While initial complete responses are not uncommon, there is a fair chance of relapse as late as one to two decades after initial therapy.


Stage M2 Embryonal Tumor with Multilayered Rosettes

Gross nodular seeding is detected in the cerebellar/cerebral subarachnoid space or in the third or lateral ventricles. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Stage M3 Atypical Teratoid/Rhabdoid Tumor

Gross nodular seeding is detected in the spinal subarachnoid space. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Childhood Medulloblastoma by Toronto Guidelines v2 Stage

A term that refers to the staging of childhood medulloblastoma according to the Toronto childhood cancer staging guidelines v2.


Grade 4 Urinary Hemorrhage NOS, CTCAE

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Acute cholecystitis without calculus

Acute inflammation of the gallbladder in the absence of gallstones


Calculus of gallbladder with cholecystitis

An acute or chronic inflammation of the gallbladder associated with the presence of gallstones.


Chronic acalculous cholecystitis

Chronic cholecystitis not associated with the presence of gallstones.


Grade 4 Cervix Infection with Unknown Absolute Neutrophil Count, CTCAE


Intracranial Mesenchymal Tumor, FET-CREB Fusion-Positive

A provisional entity that refers to a group of neoplasms with a broad morphological spectrum, characterized by fusion of a FET family gene (usually EWSR1 and rarely FUS) with a member of the CREB family of transcription factors (CREB1, ATF1, or CREM). It includes entities previously termed intracranial angiomatoid fibrous histiocytoma or intracranial myxoid mesenchymal tumor. It is usually located in the supratentorial brain and mostly affects children and young adults. There is a spectrum of clinical behaviors ranging from slowly growing tumors to rapid recurrences, and rarely metastases.


capsaicinoid

A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.


Grade 3 Pain, CTCAE

Severe pain; limiting self care ADL


Diffuse Low Grade Glioma, FGFR1-Mutant

Diffuse low-grade glioma characterized by FGFR1 gene mutations, an internal tandem duplication within the FGFR1 gene or the presence of an FGFR1 fusion gene.


Grade 1 Ventricular Arrhythmia NOS, CTCAE


Grade 4 Premature Delivery, CTCAE

Delivery of a liveborn infant at 24 weeks of gestation or less


Stage IV Rectosigmoid Cancer AJCC v7

Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Astler-Coller B1 Rectal Carcinoma

Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.)


Postprocedural respiratory disorders

A respiratory disorder occurring as a consequence of a procedure.


Grade 2 Salivary Duct Intra-Operative Injury, CTCAE


Salivary Duct Intra-Operative Injury, CTCAE


Grade 4 Salivary Duct Intra-Operative Injury, CTCAE


Grade 3 Salivary Duct Intra-Operative Injury, CTCAE


Grade 1 Salivary Duct Intra-Operative Injury, CTCAE


Vulvar Neoplasm of Skin Appendage Origin

A benign or malignant vulvar neoplasm with differentiating characteristics towards sweat or sebaceous glands or hair follicles.  Representative examples include trichoepithelioma, syringoma, and eccrine adenocarcinoma.


Malignant Vulvar Sweat Gland Neoplasm

A malignant neoplasm that arises from sweat glands in the vulva. Representative examples include eccrine adenocarcinoma, apocrine adenocarcinoma, and Paget disease.


Vulvar Hidradenoma Papilliferum

A benign glandular neoplasm that arises from the vulva. It presents as a mass or cystic lesion in or adjacent to the interlabial sulcus. It is characterized by the presence of complex branching papillae with fibrovascular stalks, lined by uniform columnar epithelial secretory cells and myoepithelial cells.


Vulvar Adenocarcinoma of Sweat Gland Origin

A rare adenocarcinoma arising from vulvar skin sweat glands.


Cirrhosis of the Liver Secondary to Hepatitis C

Cirrhosis of the liver that develops as a sequelae of a hepatitis c infection.


Stage IIA2 Cervical Cancer FIGO 2018

Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, equal or more than 4 cm in greatest dimension. (FIGO 2018)


Grade 3 Lymphatic Infection with Unknown Absolute Neutrophil Count, CTCAE


Compounds based on a triazine skeleton.


Any compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure.


Any compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure.


Any member of the class of 1,3,5-triazines that consists of a 1,3,5-triazine skeleton substituted by two amino groups.


quinazoline

A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.


Grade 4 Urinary Tract Obstruction, CTCAE

Life-threatening consequences; urgent intervention indicated


Anaplastic Hemispheric Astrocytoma

An anaplastic astrocytoma that arises from the cerebral hemispheres.


Frontal Lobe Anaplastic Astrocytoma

An anaplastic astrocytoma occurring in the frontal lobe.


Cerebral Hodgkin Lymphoma

A Hodgkin lymphoma that arises from the cerebral hemispheres as a primary lesion.


Infant-Type Hemispheric Glioma, MET-Altered

A high-grade cellular astrocytoma that arises in the cerebral hemisphere and occurs in early childhood. It is characterized by receptor tyrosine kinase fusions in the MET gene.


Parietal Lobe Anaplastic Astrocytoma

An anaplastic astrocytoma occurring in the parietal lobe.


Infant-Type Hemispheric Glioma, ALK-Altered

A high-grade cellular astrocytoma that arises in the cerebral hemisphere and occurs in early childhood. It is characterized by receptor tyrosine kinase fusions in the ALK gene.


Temporal Lobe Anaplastic Astrocytoma

An anaplastic astrocytoma occurring in the temporal lobe.


Adult Diffuse Hemispheric Glioma, H3 G34-Mutant

A diffuse hemispheric glioma, H3 G34-mutant that occurs in young adults.


Childhood Cerebral Anaplastic Astrocytoma

A cerebral anaplastic astrocytoma that occurs during childhood.


Childhood Diffuse Hemispheric Glioma, H3 G34-Mutant

A diffuse hemispheric glioma, H3 G34-mutant that occurs during childhood.


Infant-Type Hemispheric Glioma, NTRK-Altered

A high-grade cellular astrocytoma that arises in the cerebral hemisphere and occurs in early childhood. It is characterized by receptor tyrosine kinase fusions in the NTRK family.


Grade 4 Eye Infection, CTCAE

Life-threatening consequences; urgent intervention indicated; enucleation


Grade 3 Salivary Gland or Saliva Changes, CTCAE


Epithelioid Hemangioendothelioma with WWTR1-CAMTA1 Gene Fusion

Epithelioid hemangioendothelioma characterized by a t(1;3)(p36;q23-q25) translocation, resulting in a WWTR1-CAMTA1 gene fusion. This translocation and associated gene fusion occur in more than 90% of epithelioid hemangioendotheliomas.


Grade 3 Hyperglycemia, CTCAE

Insulin therapy initiated; hospitalization indicated


Liver Pain, CTCAE

An adverse event characterized by pain originating in the liver.


Laryngeal Inflammatory Myofibroblastic Tumor

An inflammatory myofibroblastic tumor that arises from the larynx.


Grade 2 Cushingoid, CTCAE

Moderate symptoms; medical intervention indicated


Grade 2 Tendon Reflex Decreased, CTCAE

Ankle reflex absent; other reflexes reduced


Grade 4 Lower Extremity Vein Intra-Operative Injury, CTCAE


Orbital emphysema

The presence of air or gas in the subcutaneous tissue of the orbit of the eye.


Grade 4 Urostomy Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 1 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Corrected Prolonged QT Interval by ECG Finding

An electrocardiographic finding in which the QTc interval corrected for heart rate is prolonged. Thresholds for different age, gender, and patient populations exist. (CDISC)


Hydroxychloroquine-triggered QTc Interval Prolongation

QTc interval prolongation that is seen as an adverse event in some patients with co-morbid cardiovascular disease who are treated with hydroxychloroquine.


purine ribonucleotide

Any ribonucleotide that has a purine nucleobase.


adenyl ribonucleotide

A purine riboncleotide where adenine is the purine.


Grade 3 Vagus Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Recurrent Sarcoma of the Extremity

A sarcoma of the soft tissues or bones of the upper or lower extremity that has recurred after a period of remission.


Stage II Small Intestinal Gastrointestinal Stromal Tumor

Stage II includes: T3, N0, M0, Mitotic rate: Low.  T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage III Rectal Cancer AJCC v7

Stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Advanced Colorectal Carcinoma

Colorectal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Hereditary Colon Carcinoma

Colon carcinoma that has developed in relatives of patients with a history of colon carcinoma.


Colorectal Neuroendocrine Tumor

A well differentiated,  low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the colon or rectum.


Stage IIB Small Intestinal Cancer AJCC v7

Stage IIB includes: T4, N0, M0. T4: Tumor perforates the visceral peritoneum or directly invades other organs or structures (including other loops of small intestine, mesentery, or retroperitoneum more than 2 cm, and abdominal wall by way of serosa; for duodenum only, invasion of pancreas or bile duct). N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Intestinal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the small or large intestine. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Intestinal Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small or large intestine. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Non-Neoplastic Intestinal Disorder

A disorder that affects the small or large intestine and is non-neoplastic in nature. Representative examples include acute appendicitis, colitis, and inflammatory bowel disease.


Colorectal Conventional Adenoma

A benign, premalignant colorectal neoplasm composed of dysplastic epithelium. The descriptor "conventional" distinguishes this from lesions in the serrated pathway. (WHO 2019)


Stage II Colorectal Cancer AJCC v8

Stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colon Serrated Adenocarcinoma

A rare, invasive colon adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture.


Jejunal web

The formation of tissue in the lumen of the jejunum that results in partial obstruction.


Adenoma of the Colon with Intramucosal Adenocarcinoma

An intramucosal malignant glandular epithelial infiltrate in a colonic adenoma.  There is no evidence of submucosal invasion.


Rectal Conventional Adenoma

A benign, premalignant rectal neoplasm composed of dysplastic epithelium. The descriptor "conventional" distinguishes this from lesions in the serrated pathway. (WHO 2019)


Small Intestinal Undifferentiated Carcinoma

A carcinoma that arises from the small intestine.  It is composed of malignant epithelial cells which do not display evidence of glandular, squamous, or transitional cell differentiation.


Colon Conventional Adenoma

A benign, premalignant colon neoplasm composed of dysplastic epithelium. The descriptor "conventional" distinguishes this from lesions in the serrated pathway. (WHO 2019)


Unresectable Colon Adenocarcinoma

A colon adenocarcinoma that is not amenable to surgical resection.


Stage IIC Colon Cancer AJCC v7

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Colon Cancer by AJCC v8 Stage

A term that refers to the staging of colon cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to adenocarcinomas, high-grade neuroendocrine carcinomas, and squamous cell carcinomas of the colon. (from AJCC 8th Ed.)


Colorectal Perineurioma

A perineurioma that arises from the colon or rectum.  It usually presents as a small sessile polyp.


Colitis aggravated

Exacerbation of an underlying colitis.


Small Intestinal Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

A well differentiated neuroendocrine tumor that arises from the small intestine and produces serotonin.


Stage IVB Colon Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis.  (AJCC 8th ed.)


Stage I Colorectal Cancer AJCC v6 and v7

Stage I includes: (T1, N0, M0); (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Childhood Rectal Carcinoma

A rare carcinoma of the rectum that occurs during childhood.


Stage IIIA Colorectal Cancer AJCC v7

Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2a: Metastasis in 4-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIB Colorectal Cancer AJCC v8

Stage IIB includes: T4a, N0, M0. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage II Colon Cancer AJCC v8

Stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage II Duodenal Neuroendocrine Tumor AJCC v8

Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading the muscularis propria or measuring more than 1 cm. T3: Tumor invading the pancreas or peripancreatic adipose tissue. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Duodenal web

Partial or complete obstruction of the duodenal lumen due to the presence of a membranous web.


Clostridium sordellii colitis

Inflammation of the colon resulting from Clostridium Sordelli.


Stage 0 Small Intestinal Adenocarcinoma AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: High grade dysplasia/carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Colorectal Adenocarcinoma

A colorectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with 50-95% glandular formation.


Small Intestinal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the small intestine. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Colorectal Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the colon and rectum. The Ki-67 index is higher than 20%.


Stage IVB Colorectal Cancer AJCC v7

Stage IVB includes: Any T, Any N, M1b.  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Rectosigmoid cancer recurrent

The reemergence of rectosigmoid carcinoma after a period of remission.


Ileal Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the ileum. The Ki-67 index is higher than 20%.


Stage IIIC Rectal Cancer AJCC v7

Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes. N2: Metastasis in four or more regional lymph nodes. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Rectosigmoid Cancer AJCC v6

Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


Rectosigmoid Cancer by AJCC v7 Stage

A term that refers to the staging of rectosigmoid carcinoma according to the American Joint Committee on Cancer, 7th edition.


Metastatic Malignant Colorectal Neoplasm

A malignant neoplasm that arises in the colon or rectum that has spread from its original site of growth to other anatomic sites.


Colorectal Cowden-Associated Polyp

A hamartomatous polyp that arises from the colon and rectum and it is associated with the presence of Cowden syndrome.


Colorectal Adenoma with Moderate Dysplasia

An adenoma that arises from the colon or rectum.  It is characterized by the presence of moderate epithelial dysplasia.


Metastatic Rectal Carcinoma

A carcinoma that arises from the rectum and has metastasized to another anatomic site.


Stage IV Ileal Neuroendocrine Tumor AJCC v8

Stage IV includes: (T1, N0, N1, N2, M1); (T2, N0, N1, N2, M1); (T3, N0, N1, N2, M1); (T4, N0, N1, N2, M1). T1: Tumor invading lamina propria or submucosa and measuring 1 cm or less in size. T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis in less than 12 nodes. N2: Large mesenteric masses (larger than 2 cm) and/or extensive nodal deposits (12 or greater), especially those that encase the superior mesenteric vessels. M1: Distant metastasis. (AJCC 8th ed.)


Jejunal Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the jejunum. The Ki-67 index is higher than 20%.


Stage IVC Colon Cancer AJCC v8

Stage IVC includes: Any T, Any N, M1c. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Chronic Active Colitis

Chronic colitis with superimposed neutrophilic mucosal infiltrates. It is usually seen during exacerbations of inflammatory bowel disease.


Rectal Cancer by AJCC v6 Stage

A term that refers to the staging of rectal carcinoma according to the American Joint Committee on Cancer, 6th edition.


Small Intestinal Cancer by AJCC v7 Stage

A term that refers to the staging of small intestinal cancer according to the American Joint Committee on Cancer, 7th edition.


Stage IIIA Rectal Cancer AJCC v8

Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage I Ileal Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invading lamina propria or submucosa and measuring 1 cm or less in size. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Sigmoid Colon Neuroendocrine Tumor G1

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the sigmoid colon. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Non-infective Inflammatory Bowel Disease

A disease of the intestines that is inflammatory but not infectious.


Colorectal Inflammatory Polyp

A non-neoplastic polypoid lesion in the colon and rectum.  It may arise in a background of inflammatory bowel disease or colitis.  It is characterized by the presence of a distorted epithelium, inflammation, and fibrosis.


Colorectal Benign Granular Cell Tumor

A granular cell tumor that arises from the colon or rectum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Refractory Colon Carcinoma

Colon carcinoma that is resistant to treatment.


Stage IVB Colorectal Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis.  (AJCC 8th ed.)


Rectal Mucositis

An inflammatory process affecting the mucous membrane of the rectum.


Small Intestinal Myeloid Sarcoma

An extramedullary myeloid tumor that arises from the small intestine. It often presents with abdominal pain and obstruction.


Colorectal Cancer by AJCC v6 Stage

A term that refers to the staging of colorectal carcinoma according to the American Joint Committee on Cancer, 6th edition.


Colorectal Neuroendocrine Neoplasm

A neoplasm with neuroendocrine differentiation that arises from the colon or rectum. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Unresectable Colon Carcinoma

Colon carcinoma that is not amenable to surgical resection.


Childhood Colorectal Carcinoma

A rare colorectal carcinoma that occurs during childhood.


Grade 1 Colorectal Adenocarcinoma

A colorectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with more than 95% glandular formation.


Duodenal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the duodenum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage II Colon Cancer AJCC v7

Stage II includes: IIA (T3, N0, M0); IIB (T4a, N0, M0); IIC (T4b, N0, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IVA Rectal Cancer AJCC v8

Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis to one site or organ without peritoneal metastasis. (AJCC 8th ed.)


Colorectal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the colon or rectum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Locally Recurrent Colorectal Carcinoma

The reemergence of colorectal carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Microsatellite Stable Colorectal Carcinoma

Colorectal carcinoma characterized by the absence of microsatellite instability.


Refractory Colorectal Carcinoma

Colorectal carcinoma that does not respond to treatment.


Colon Intramucosal Adenocarcinoma

An adenocarcinoma that arises from the colonic glandular epithelium and invades the lamina propria or muscularis mucosa but not the submucosa.


Colonic tubulovillous adenoma

A neoplasm that arises from the glandular epithelium of the colonic mucosa. It is characterized by tubular and villous architectural patterns. The neoplastic glandular cells have dysplastic features.


Intestinal Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the small or large intestine. The Ki-67 index is higher than 20%.


Colorectal Cribriform Comedo-Type Adenocarcinoma

A rare, invasive colorectal adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.


Refractory Colon Adenocarcinoma

Colon adenocarcinoma that is resistant to treatment.


Stage IIC Colon Cancer AJCC v8

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Colorectal Cancer AJCC v7

Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Stage II Jejunal Neuroendocrine Tumor AJCC v8

Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage II Rectal Cancer AJCC v8

Stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Unresectable Rectal Adenocarcinoma

A rectal adenocarcinoma that is not amenable to surgical resection.


Stage III Small Intestinal Adenocarcinoma AJCC v8

Stage III includes: IIIA: Any T, N1, M0; IIIB: Any T, N2, M0. N1: Metastasis in one or two regional lymph nodes. N2: Metastasis in three or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Colorectal Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon or rectum. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Stage IIIA Small Intestinal Cancer AJCC v7

Stage IIIA includes: Any T, N1, M0. N1: Metastasis in 1-3 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Intestinal Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor

A usually indolent neuroendocrine neoplasm that arises in the intestine. Patients may present with gastrointestinal hemorrhage. It is a triphasic tumor consisting of a mixture of epithelioid neuroendocrine cells, Schwann-like cells, and ganglion cell-like elements.


Rectosigmoid Mucinous Adenocarcinoma

An invasive adenocarcinoma of the rectosigmoid area characterized by the presence of pools of extracellular mucin.  Malignant glandular epithelial cells are present in the mucin collections.  Mucin constitutes more than 50% of the lesion.


Stage 0 Rectosigmoid Cancer AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial or invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Stage IVC Rectal Cancer AJCC v8

Stage IVC includes: Any T, Any N, M1c. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Colon Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the colon. The Ki-67 index is higher than 20%.


Rectal Cancer by AJCC v7 Stage

A term that refers to the staging of rectal carcinoma according to the American Joint Committee on Cancer, 7th edition.


Stage IVA Colorectal Cancer AJCC v7

Stage IVA includes: Any T, Any N, M1a.  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  (AJCC 7th ed.)


Stage IVB Colon Cancer AJCC v7

Stage IVB includes: Any T, Any N, M1b. M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Grade 2 Colon Adenocarcinoma

A colon adenocarcinoma characterized by the presence of a malignant cellular infiltrate with 50-95% glandular formation.


Stage III Colorectal Cancer AJCC v6

Stage Group III is subdivided into IIIA (T1-2, N1, M0), IIIB (T3-4, N1, M0) or IIIC (any T, N2 M0).  T1: Tumor invades the submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into the subserosa or into non-peritonealized pericolic or perirectal tissues.  T4: Tumor directly invades other organs or structures, and/or perforates visceral peritoneum.  N1: Metastasis in 1 to 3 regional lymph nodes N2: Metastasis in 4 or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 6th ed.)


Stage IV Small Intestinal Adenocarcinoma AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Grade 1 Colon Adenocarcinoma

A colon adenocarcinoma characterized by the presence of a malignant cellular infiltrate with more than 95% glandular formation.


Small Intestinal Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the small intestine. The Ki-67 index is higher than 20%.


Carcinoma of sigmoid colon

A carcinoma that arises from the sigmoid colon.


Stage II Colorectal Cancer AJCC v6

Stage Group II is subdivided into IIA and IIB on the basis of whether the primary tumor is T3 or T4, respectively.  T3: Tumor invades through the muscularis propria into the subserosa, or into non-peritonealized pericolic or perirectal tissues.  T4: Tumor directly invades other organs or structures, and/or perforates visceral peritoneum. (AJCC 6th ed.)


Suspected Necrotizing Enterocolitis

The diagnosis assigned when a health care practitioner feels strongly the patient has necrotizing enterocolitis, but lacks definitive proof.


Colorectal Angiosarcoma

An angiosarcoma that arises from the colon or rectum.


Locally Advanced Colon Adenocarcinoma

Colon adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Colorectal Mixed Adenoneuroendocrine Carcinoma

A carcinoma that arises from the colon or rectum and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Colorectal Small Cell Neuroendocrine Carcinoma

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon or rectum.  It is characterized by the presence of malignant small cells.


Metastatic Microsatellite Stable Colon Carcinoma

Microsatellite stable colon carcinoma that has spread from its original site of growth to another anatomic site.


Stage IIIA Colon Cancer AJCC v7

Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. N1: Metastasis in 1-3 regional lymph nodes. N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2a: Metastasis in 4-6 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Small Intestinal Mixed Adenoneuroendocrine Carcinoma

A carcinoma that arises from the small intestine and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Small Intestinal High Grade Intraepithelial Neoplasia

A precancerous neoplastic process that affects the small intestine.  It is characterized by moderate or severe epithelial dysplasia and complex architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


Rectal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the rectum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Congenital atresia of large intestine

A malformation characterized by the absence of a normal opening in a part of the large intestine.


Small Intestinal Low Grade Intraepithelial Neoplasia

A precancerous neoplastic process that affects the small intestine.  It is characterized by mild epithelial dysplasia and mild architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


Locally Advanced Colorectal Carcinoma

A colorectal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage 0 Rectal Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ, intramucosal carcinoma (involvement of lamina propria with no extension through muscularis mucosae). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Colon Cancer AJCC v6

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.)


Colorectal Sarcoma

A malignant soft tissue neoplasm that arises from the colon or rectum.  Representative examples include angiosarcoma, Kaposi sarcoma, and leiomyosarcoma.


Microsatellite Stable Colon Carcinoma

Colon carcinoma characterized by the absence of microsatellite instability.


Typhlitis

Inflammation of the cecum, usually accompanied by neutropenia.


Stage II Small Intestinal Adenocarcinoma AJCC v8

Stage II includes: IIA: T3, N0, M0; IIB: T4, N0, M0. T3: Tumor invading through the muscularis propria into the subserosa, or extending into nonperitonealized perimuscular tissue (mesentery or retroperitoneum) without serosal penetration. For T3 tumors, the nonperitonealized perimuscular tissue is, for the jejunum and ileum, part of the mesentery and, for the duodenum in areas where serosa is lacking, part of the interface with the pancreas. T4: Tumor perforating the visceral peritoneum or directly invading other organs or structures (e.g., other loops of small intestine, mesentery of adjacent loops of bowel, and abdominal wall by way of serosa; for duodenum only, invasion of pancreas or bile duct). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Small Intestinal Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor

A usually indolent neuroendocrine neoplasm that arises in the small intestine. Patients may present with gastrointestinal hemorrhage. It is a triphasic tumor consisting of a mixture of epithelioid neuroendocrine cells, Schwann-like cells, and ganglion cell-like elements.


Cecal Infection

An infectious process affecting the cecum.


Stage IIIB Rectal Cancer AJCC v8

Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Carcinoma in the Rectum

A carcinoma that has spread to the rectum from another anatomic site.


Stage III Ileal Neuroendocrine Tumor AJCC v8

Stage III includes: (T1, N1, N2, M0); (T2, N1, N2, M0); (T3, N1, N2, M0); (T4, N0, M0); (T4, N1, N2, M0). T1: Tumor invading lamina propria or submucosa and measuring 1 cm or less in size. T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis in less than 12 nodes. N2: Large mesenteric masses (larger than 2 cm) and/or extensive nodal deposits (12 or greater), especially those that encase the superior mesenteric vessels. M0: No distant metastasis. (AJCC 8th ed.)


Refractory Rectal Adenocarcinoma

Rectal adenocarcinoma that is resistant to treatment.


Colon Hodgkin Lymphoma

An extranodal Hodgkin lymphoma that arises from the colon.


Tubular adenoma of colon

A usually polypoid neoplasm that arises from the glandular epithelium of the colonic mucosa. It is characterized by a tubular architectural pattern. The neoplastic glandular cells have dysplastic features.


Stage II Colorectal Cancer AJCC v7

Stage II includes: IIA (T3, N0, M0); IIB (T4a, N0, M0); IIC (T4b, N0, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Unresectable Microsatellite Stable Colorectal Carcinoma

Microsatellite stable colorectal carcinoma that is not amenable to surgical resection.


Stage IIIC Rectal Cancer AJCC v8

Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Adenocarcinoma that arises from the periampullary region and is not amenable to surgical resection.


Inflammatory Bowel Disease-Associated Colorectal Adenocarcinoma

A colorectal adenocarcinoma that develops in patients with a history of inflammatory bowel disease.


Small Intestinal Adenocarcinoma by AJCC v8 Stage

A term that refers to the staging of small intestinal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition. Nonadenocarcinomas arising in the small intestine should have a TNM assigned but are not assigned a stage classification. (from AJCC 8th Ed.)


Colon Cancer by AJCC v7 Stage

A term that refers to the staging of colon carcinoma according to the American Joint Committee on Cancer, 7th edition.


Rectal Cancer by AJCC v8 Stage

A term that refers to the staging of rectal cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to adenocarcinomas, high-grade neuroendocrine carcinomas, and squamous cell carcinomas of the rectum. (from AJCC 8th Ed.)


Small Intestinal Adenosquamous Carcinoma

A carcinoma that arises from the small intestine.  It is composed of malignant glandular cells and malignant squamous cells.


Radiation enteritis of intestine

Inflammation of the small intestine caused by radiation exposure.


Colorectal Intraepithelial Neoplasia

A precancerous neoplastic process that affects the colon or rectum.  It is characterized by low or high grade dysplasia of the mucosal epithelium.  There is no evidence of invasion.


Ulcerative Colitis-Associated Colorectal Adenocarcinoma

A colorectal adenocarcinoma that develops in patients with a history of ulcerative colitis.  Such carcinomas are usually multiple and flat.  Histologically, they are usually mucinous or signet-ring cell type.


Colorectal Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

A well differentiated neuroendocrine tumor that arises from the colon or rectum and produces serotonin.


Small Intestinal Kaposi Sarcoma

A Kaposi sarcoma that arises from the small intestine.


Colon Serrated Polyposis

The presence of multiple serrated polyps in the colon. The polyps are predominantly sessile serrated adenomas/polyps. A minority of the polyps are microvesicular variants of hyperplastic polyps. According to some authors, the polyps are proximal to the sigmoid colon. According to others, the polyps are distributed throughout the entire colon.


Grade 2 Rectal Adenocarcinoma

A rectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with 50-95% glandular formation.


Stage IV Colon Cancer AJCC v7

Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Duodenal Extraskeletal Osteosarcoma

An extraskeletal osteosarcoma affecting the duodenum.


Stage IV Small Intestinal Gastrointestinal Stromal Tumor

Stage IV includes: (Any T, N1, M0, Mitotic rate: Any rate); (Any T, Any N, M1, Mitotic rate: Any rate).  N1: Regional lymph node metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


Small Intestinal Mucositis

An inflammatory process affecting the mucous membrane of the small intestine.


Stage IIIB Colorectal Cancer AJCC v8

Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Carcinoma in situ of small intestine

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Hypermutated Colorectal Carcinoma

A colorectal carcinoma characterized by a high mutational rate caused by DNA mismatch repair deficiency or POLE/POLD1 driver mutations.


Stage IIA Small Intestinal Cancer AJCC v7

Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into the subserosa or into the nonperitonealized perimuscular tissue (mesentery or retroperitoneum) with extension 2 cm or less.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Colorectal hyperplastic polyp

A serrated polypoid lesion that arises in the colon and rectum.  It is usually found in the distant colon and it rarely produces symptoms.  This group includes goblet cell rich, mucin poor, and microvesicular hyperplastic polyps.


Stage IIIA Colorectal Cancer AJCC v8

Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Colon Hyperplastic Polyp

A serrated polypoid lesion that arises in the colon.  It is usually found in the distant colon and it rarely produces symptoms.  This group includes goblet cell rich, mucin poor, and microvesicular hyperplastic polyps.


Colorectal High Grade Intraepithelial Neoplasia

A precancerous neoplastic process that affects the colon or rectum.  It is characterized by moderate or severe epithelial dysplasia and complex architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


Stage IIA Colorectal Cancer AJCC v8

Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Colorectal Mucinous Adenocarcinoma

Colorectal mucinous adenocarcinoma that has spread from the original site of growth to other anatomic sites.


Small Intestinal Medullary Carcinoma

A carcinoma that arises from the small intestine.  It is characterized by the presence of malignant epithelial cells with vesicular nucleus, distinct nucleolus, and abundant pink cytoplasm.


Stage I Rectal Cancer AJCC v8

Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IVA Colon Cancer AJCC v7

Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node). (AJCC 7th ed.)


Stage IIC Rectal Cancer AJCC v7

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Colorectal Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon or rectum.  It is characterized by the presence of malignant large cells.


Colon Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon. It is characterized by the presence of malignant large cells.


Stage I Rectal Cancer AJCC v6 and v7

Stage I includes: (T1, N0, M0); (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Colorectal Hodgkin Lymphoma

An extranodal Hodgkin lymphoma that arises from the colon or rectum.


Small Intestinal Gastrin-Producing Neuroendocrine Tumor

A gastrin-producing neuroendocrine tumor that arises from the small intestine.  It is characterized by the presence of uniform cells that form pseudorosettes.  The neoplastic cells have uniform nuclei and small amount of eosinophilic cytoplasm.


Unresectable Small Intestinal Adenocarcinoma

Small intestinal adenocarcinoma that is not amenable to surgical resection.


Colorectal Adenoma with Severe Dysplasia

An adenoma that arises from the colon or rectum.  It is characterized by the presence of severe epithelial dysplasia.


Small intestine carcinoma non-resectable

Carcinoma of the small intestine not amendable to resection.


Grade 1 Rectal Adenocarcinoma

A rectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with more than 95% glandular formation.


Recurrent Colorectal Adenocarcinoma

The reemergence of colorectal adenocarcinoma after a period of remission.


Duodenal Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the duodenum. The Ki-67 index is higher than 20%.


Rectal Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the rectum. The Ki-67 index is higher than 20%.


Rectosigmoid Cancer by AJCC v6 Stage

A term that refers to the staging of rectosigmoid carcinoma according to the American Joint Committee on Cancer, 6th edition.


Immune-mediated colitis

Colitis caused by an immune reaction to an antigen, including a therapeutically administered agent.


Stage II Rectosigmoid Cancer AJCC v6

Stage II includes IIA (T3, N0, M0) and IIB (T4, N0, M0). T3: Tumor invades through the muscularis propria into the subserosa, or into nonperitonealized pericolic or perirectal tissues. T4: Tumor directly invades other organs or structures, and/or perforates the visceral peritoneum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Unresectable Colorectal Carcinoma

A colorectal carcinoma that is not amenable to surgical resection.


Stage IV Colorectal Cancer AJCC v6

Stage IV includes: Any T, any N, M1.  M1: Distant metastasis. (AJCC 6th ed.)


Colorectal L-Cell Glucagon-Like Peptide-Producing Neuroendocrine Tumor

A neuroendocrine tumor that arises from the colon or rectum and produces glucagon-like peptides.  Morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns.


Stage III Colorectal Cancer AJCC v7

Stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIIC Colon Cancer AJCC v7

Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes. N2: Metastasis in four or more regional lymph nodes. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Recurrent Microsatellite Stable Colorectal Carcinoma

The reemergence of microsatellite stable colorectal carcinoma after a period of remission.


Colon Cribriform Comedo-Type Adenocarcinoma

A rare, invasive colon adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.


Colorectal Mucin Poor Hyperplastic Polyp

A serrated hyperplastic polyp that arises from the colon and rectum.  It is characterized by the presence of small cells in the crypts that do not contain mucin.  Reactive epithelial atypia may be present.


Rectosigmoid Signet Ring Cell Carcinoma

An infiltrating adenocarcinoma arising from the rectosigmoid area.  It is characterized by the presence of malignant glandular cells with prominent intracytoplasmic mucin.  These cells constitute more than 50% of the malignant cellular population.


Stage IIIB Rectal Cancer AJCC v7

Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. N1: Metastasis in 1-3 regional lymph nodes. N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Jejunal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the jejunum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IIA Rectal Cancer AJCC v7

Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage I Small Intestinal Adenocarcinoma AJCC v8

Stage I includes: T1-2, N0, M0. T1: Tumor invading the lamina propria or submucosa. T2: Tumor invading the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Jejunal ulcer

A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the jejunum.


Refractory Microsatellite Stable Colorectal Carcinoma

Microsatellite stable colorectal carcinoma that is resistant to treatment.


Stage IIB Colon Cancer AJCC v8

Stage IIB includes: T4a, N0, M0. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colon Micropapillary Adenocarcinoma

A rare, invasive colon adenocarcinoma characterized by the presence of clusters of malignant glandular cells within stromal spaces.


Stage IV Rectosigmoid Cancer AJCC v6

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th ed.)


Stage III Jejunal Neuroendocrine Tumor AJCC v8

Stage III includes: (T1, N1, N2, M0); (T2, N1, N2, M0); (T3, N1, N2, M0); (T4, N0, M0); (T4, N1, N2, M0). T1: Tumor invading lamina propria or submucosa and measuring 1 cm or less in size. T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis in less than 12 nodes. N2: Large mesenteric masses (larger than 2 cm) and/or extensive nodal deposits (12 or greater), especially those that encase the superior mesenteric vessels. M0: No distant metastasis. (AJCC 8th ed.)


Adenocarcinoma of colon recurrent

The reemergence of colon adenocarcinoma after a period of remission.


Crohn Disease-Associated Colorectal Adenocarcinoma

A colorectal adenocarcinoma that develops in patients with a history of Crohn disease.


Colorectal Villous Adenoma

A neoplasm that arises from the glandular epithelium of the colonic and rectal mucosa. It is characterized by a villous architectural pattern. The neoplastic glandular cells have dysplastic features.


Rectal Adenoma with Severe Dysplasia

An adenoma that arises from the rectum.  It is characterized by the presence of severe epithelial dysplasia.


Colorectal Ganglioneuroma

A ganglioneuroma that arises from the colon or rectum.  It usually presents as a small mucosal polyp.


Stage IIIA Small Intestinal Adenocarcinoma AJCC v8

Stage IIIA includes: Any T, N1, M0. N1: Metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Adenocarcinoma of colon metastatic

An adenocarcinoma that arises from the colon and has metastasized to another anatomic site.


Stage IIB Colorectal Cancer AJCC v7

Stage IIB includes: T4a, N0, M0.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Gastrointestinal stromal tumor of small intestine

A gastrointestinal stromal tumor that arises from the small intestine.  It usually affects adults over fifty years of age.  The majority of cases have spindle cell morphology.  The prognosis depends on the tumor size and the mitotic activity.


Rectal Micropapillary Adenocarcinoma

A rare, invasive rectal adenocarcinoma characterized by the presence of clusters of malignant glandular cells within stromal spaces.


Locally Advanced Microsatellite Stable Colorectal Carcinoma

A microsatellite stable colorectal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Rectal Serrated Adenocarcinoma

A rare, invasive rectal adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture.


Advanced Rectal Carcinoma

Rectal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Colon Ganglioneuroma

A ganglioneuroma that arises from the colon.  It usually presents as a small mucosal polyp.


Unresectable Colorectal Adenocarcinoma

Colorectal adenocarcinoma that is not amenable to surgical resection.


Colorectal Goblet Cell Rich Hyperplastic Polyp

A serrated hyperplastic polyp that arises from the colon and rectum.  It is characterized by the presence of goblet cells and the absence of microvacuolated columnar cells.  There is no evidence of epithelial atypia or dysplasia.


Stage IIA Rectal Cancer AJCC v8

Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colorectal Mucinous Adenocarcinoma

An invasive colorectal adenocarcinoma characterized by the presence of extracellular mucin pools that contain malignant glandular epithelial structures.  The extracellular mucin pools occupy more than 50% of the malignant lesion.


Colorectal Cancer by AJCC v8 Stage

A term that refers to the staging of colorectal cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to adenocarcinomas, high-grade neuroendocrine carcinomas, and squamous cell carcinomas of the colon and rectum. Appendiceal carcinomas, anal carcinomas, and well-differentiated neuroendocrine tumors (carcinoids) are not covered by this staging system. (from AJCC 8th Ed.)


Stage IIIB Colorectal Cancer AJCC v7

Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIA Colon Cancer AJCC v7

Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Colorectal Sarcomatoid Carcinoma

A biphasic colorectal carcinoma with a spindle cell, sarcomatoid component.


Stage IIB Rectal Cancer AJCC v7

Stage IIB includes: T4a, N0, M0. T4a: Tumor penetrates to the surface of the visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Colorectal Cancer by AJCC v7 Stage

A term that refers to the staging of colorectal carcinoma according to the American Joint Committee on Cancer, 7th edition.


Metastatic malignant neoplasm to large intestine

The spread of a malignant neoplasm to the large intestine.  This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site.


Crohn's disease of small intestine

Crohn's disease affecting the small intestine.


Refractory Rectal Carcinoma

Rectal carcinoma that is resistant to treatment.


Stage IIIB Small Intestinal Adenocarcinoma AJCC v8

Stage IIIB includes: Any T, N2, M0. N2: Metastasis in three or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Rectal Juvenile Polyp

A non-neoplastic hamartomatous polyp that arises from the rectum.  It is characterized by the presence of tortuous and cystically dilated glands, edematous changes, and inflammation.


Intestinal Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the small or large intestine.


Colorectal Undifferentiated Carcinoma

An invasive malignant epithelial tumor that arises from the colon or rectum.  There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation.


Rectal Serrated Lesions and Polyps

Polyps that arises from the rectum. They are characterized by the presence of serrated glands and the absence of generalized dysplasia.


Metastatic Colorectal Adenocarcinoma

Colorectal adenocarcinoma that has spread from the original site of growth to other anatomic sites.


Stage IV Colorectal Cancer AJCC v8

Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b); IVC: (Any T, Any N, M1c). M1a: Metastasis to one site or organ without peritoneal metastasis. M1b: Metastasis to two or more sites or organs without peritoneal metastasis. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Ileal Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of an ileal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This classification system applies to small bowel "carcinoid" tumors (NET G1 and G2, and rare well-differentiated G3) arising in the ileum. This classification system does not apply to high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and neuroendocrine tumors of the duodenum. (from AJCC 8th Ed.)


Lipoma of small intestine

A rare benign adipose tissue neoplasm of the small intestine.  It usually arises from the submucosa and occasionally protrudes into the lumen.


Refractory Colorectal Adenocarcinoma

Colorectal adenocarcinoma that is resistant to treatment.


Stage IIIC Colorectal Cancer AJCC v8

Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Anaplastic Carcinoma of the Rectum

An invasive malignant epithelial tumor that arises from the rectum.  There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation.


Stage II Rectal Cancer

Stage II includes IIA (T3, N0, M0) and IIB (T4, N0, M0). T3: Tumor invades through the muscularis propria into the subserosa, or into nonperitonealized pericolic or perirectal tissues. T4: Tumor directly invades other organs or structures, and/or perforates the visceral peritoneum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IIIA Rectal Cancer AJCC v7

Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. N1: Metastasis in 1-3 regional lymph nodes. N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2a: Metastasis in 4-6 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Colorectal Peutz-Jeghers Polyp

A non-neoplastic hamartomatous polyp that arises from the colon and rectum.  It is characterized by the presence of smooth muscle branching bands, and cystic mucosal changes.


Metastatic malignant neoplasm to small intestine

A malignant neoplasm that has spread to the small intestine from another anatomic site.


Small Intestinal Signet Ring Cell Carcinoma

An invasive adenocarcinoma that arises from the small intestine.  It is characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus.


Stage IVA Colon Cancer AJCC v8

Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis to one site or organ without peritoneal metastasis. (AJCC 8th ed.)


Stage I Jejunal Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invading lamina propria or submucosa and measuring 1 cm or less in size. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Duodenal cancer recurrent

The reemergence of a malignant duodenal neoplasm after a period of remission.


Locally Advanced Rectal Carcinoma

Rectal carcinoma that has spread to nearby tissues or lymph nodes.


Stage IIA Colorectal Cancer AJCC v7

Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Ulcerative Colitis Flare

An exacerbation of ulcerative colitis.


Stage III Rectosigmoid Cancer AJCC v7

Stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Colorectal Cancer AJCC v8

Stage III includes: IIIA: (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Intestinal Neuroendocrine Tumor

A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the small or large intestine.


Rectal Small Cell Neuroendocrine Carcinoma

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the rectum.  It is characterized by the presence of malignant small cells.


Stage 0 Colorectal Cancer AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial or invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Colitis due to radiation

Inflammation of the colon resulting from irradiation.


Grade 3 Rectal Adenocarcinoma

A rectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with less than 50% glandular formation.


Microsatellite Stable Rectal Carcinoma

Rectal carcinoma characterized by the absence of microsatellite instability.


Colorectal Tubular Adenoma

A usually polypoid neoplasm that arises from the glandular epithelium of the colonic and rectal mucosa. It is characterized by a tubular architectural pattern. The neoplastic glandular cells have dysplastic features.


Stage I Colorectal Cancer AJCC v8

Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage III Rectal Cancer AJCC v6

Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.)


Stage III Duodenal Neuroendocrine Tumor AJCC v8

Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor invading the visceral peritoneum (serosa) or other organs. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Oligometastatic Colorectal Carcinoma

Colorectal carcinoma that has metastasized to a limited number of sites.


Stage IIA Small Intestinal Adenocarcinoma AJCC v8

Stage IIA includes: T3, N0, M0. T3: Tumor invading through the muscularis propria into the subserosa, or extending into nonperitonealized perimuscular tissue (mesentery or retroperitoneum) without serosal penetration. For T3 tumors, the nonperitonealized perimuscular tissue is, for the jejunum and ileum, part of the mesentery and, for the duodenum in areas where serosa is lacking, part of the interface with the pancreas. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Locally Advanced Microsatellite Stable Colon Carcinoma

Microsatellite stable colon carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IV Duodenal Neuroendocrine Tumor AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Ileal Web

The formation of tissue in the lumen of the ileum that results in partial obstruction.


Stage I Colon Cancer AJCC v6 and v7

Stage I includes: (T1, N0, M0); (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IVC Colorectal Cancer AJCC v8

Stage IVC includes: Any T, Any N, M1c. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Short segment Hirschsprung's disease

The most common form of Hirschsprung Disease, this is characterized by a lack of nerve cells in the sigmoid colon and rectum. The bowel is not stimulated without innervation and obstruction ensues. Surgical intervention is necessary.


Colorectal Adenoma-Like Adenocarcinoma

A well differentiated colorectal adenocarcinoma with good prognosis. It resembles a villous adenoma on the surface.


Colorectal Schwannoma

A schwannoma that arises from the colon or rectum.  It may cause gastrointestinal bleeding and luminal obstruction.


Stage I Rectosigmoid Cancer AJCC v6 and v7


Stage IV Colon Cancer AJCC v8

Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b); IVC: (Any T, Any N, M1c). M1a: Metastasis to one site or organ without peritoneal metastasis. M1b: Metastasis to two or more sites or organs without peritoneal metastasis. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Small Intestinal Villous Adenoma

A neoplasm that arises from the glandular epithelium of the small intestine. It is characterized by a villous architectural pattern. The neoplastic glandular cells have dysplastic features.


Stage IIIA Small Intestinal Gastrointestinal Stromal Tumor

Stage IIIA includes: (T1, N0, M0, Mitotic rate: High); (T4, N0, M0, Mitotic rate: Low).  T1: Tumor 2 cm or less in greatest dimension.  T4: Tumor more than 10 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Rectal Gastrointestinal Stromal Tumor

Gastrointestinal stromal tumor that arises from the rectum.


Colorectal cancer recurrent

The reemergence of colorectal carcinoma after a period of remission.


Colon Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

A well differentiated neuroendocrine tumor that arises from the colon and produces serotonin.


Stage IIIB Colon Cancer AJCC v7

Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. N1: Metastasis in 1-3 regional lymph nodes. N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Colon Cancer AJCC v7

Stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Duodenal carcinoma recurrent

The reemergence of duodenal carcinoma after a period of remission.


Ileal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ileum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Transverse Colon Neuroendocrine Tumor G1

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the transverse colon. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Stage IIIC Colorectal Cancer AJCC v7

Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes.  N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Small Intestinal Angiosarcoma

An angiosarcoma that arises from the small intestine.