African iron overload

African iron overload is a rare disorder described in sub-Saharan African populations and is characterized by iron overload due to excess dietary iron intake and possibly genetic factors, leading to hepatic portal fibrosis and micronodular cirrhosis.


testicular non-seminomatous germ cell tumor

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A testicular germ cell tumor characterized by the absence of a seminomatous component. It includes embryonal carcinoma, yolk sac tumor, choriocarcinoma, teratoma, and mixed forms.


craniosynostosis cleft lip palate arthrogryposis


childhood testicular mixed germ cell cancer

A malignant mixed germ cell neoplasm that arises from the testis during childhood.


eosinophilic meningitis

Meningitis in which eosinophils predominate in the cerebrospinal fluid.


A disorder characterized by an enduring pattern of inflexibility, extreme orderliness, and perfectionism which interfere with efficiency and which may manifest in many different contexts, including work and leisure activities, financial matters, and issues of morality or ethics.


Cayman type cerebellar ataxia

Cerebellar ataxia, Cayman type is characterized by psychomotor retardation, hypotonia and cerebellar dysfunction (nystagmus, ataxic gait, truncal ataxia, dysarthric speech and intention tremor), associated with cerebellar hypoplasia.


cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 4

Any dysequilibrium syndrome in which the cause of the disease is a mutation in the ATP8A2 gene.


spondyloepiphyseal dysplasia tarda, autosomal recessive, Leroy-Spranger type


mosaic variegated aneuploidy syndrome 1

Any mosaic variegated aneuploidy syndrome in which the cause of the disease is a mutation in the BUB1B gene.


acute myeloid leukemia with t(8;16)(p11;p13) translocation

A distinct form of Acute myeloid leukemia (AML) in which this chromosomal anomaly is found de novo or in therapy-related AML cases, and is characterized by frequent extramedullary involvement (mainly hepatomegaly, splenomegaly, lymphadenopathies, cutaneous infiltration, but also gum, bone, central nervous system, testicles involvement), severe coagulation disorder (disseminated intravascular coagulopathy or primary fibrinolysis) and poor prognosis. Morphologically, a blast population with a myelomonocytic stage of differentiation is observed.


mitochondrial myopathy with reversible cytochrome C oxidase deficiency


postlingual non-syndromic genetic hearing loss

Postlingual non-syndromic genetic deafness is a rare, genetically highly heterogeneous otorhinolaryngologic disease, resulting from inner and/or middle ear or hearing nerve anomalies, typically characterized by progressive, bilateral, moderate to profound hearing loss (mean sensorineural hearing impairment equal to 40 dB or more for 500-, 1,000-, and 2,000-Hz frequency tones in the better ear) which occurs after the onset of speech development and is not associated with visible external ear abnormalities or any other medical problems. Language development is not initially significantly delayed.


amino sulfonic acid

An organosulfonic acid containing one or more amino groups.


Childhood Acute Eosinophilic Leukemia

An acute eosinophilic leukemia occurring in children.


CIC-rearranged sarcoma

An undifferentiated, high grade small round cell sarcoma affecting predominantly young adults. It is characterized by a recurrent translocation involving the CIC gene on chromosome 19 and either DUX4 gene on chromosome 4 or DUX4L gene on chromosome 10. The translocation results in either CIC-DUX4, t(4;19)(q35;q13) or CIC-DUX4L, t(10;19)(q26;q13) fusions.


Childhood CIC-Rearranged Sarcoma

A CIC-rearranged sarcoma that occurs during childhood.


Central Nervous System CIC-Rearranged Sarcoma

A rare, undifferentiated, high grade small round cell sarcoma that arises from the central nervous system. It is characterized by a recurrent translocation involving the CIC gene on chromosome 19 resulting in CIC gene fusion with different gene partners.


CIC-DUX4L Sarcoma

An undifferentiated, high grade small round cell sarcoma affecting predominantly young adults. It is characterized by a recurrent translocation involving the CIC gene on chromosome 19 and DUX4L gene on chromosome 10. The translocation results in CIC-DUX4L, t(10;19)(q26;q13) fusions.


Circumscribed Morphea

A type of morphea in which the lesions are circular or ovoid, and may be superficial or deep. The superficial lesions can have an indurated, waxy, ivory colored center with surrounding erythema or violaceous color during the active stage. Deep lesions can be sclerotic and depressed from underlying atrophy, and may show minimal skin color changes. When there are several (greater than or equal to 4), larger (greater than 3cm) lesions on two or more body areas this is classified as "generalized morphea".


Plaque morphea

Circumscribed morphea in which the lesions are restricted to the skin and the immediately underlying subcutaneous tissues.


Deep Circumscribed Morphea

Circumscribed morphea in which the lesions are found in the deep dermis, panniculus, fascia, or superficial muscle.


Unresectable Skin Squamous Cell Carcinoma

Skin squamous cell carcinoma that is not amenable to surgical resection.


Unresectable Skin Carcinoma

Skin carcinoma that is not amenable to surgical resection.


Unresectable Skin Basal Cell Carcinoma

Basal cell carcinoma of the skin that is not amenable to surgical resection.


Unresectable Merkel Cell Carcinoma

Merkel cell carcinoma that is not amenable to surgical resection.


Unresectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that is not amenable to surgical resection.


Incongruent Visual Field Defect

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

Non-identically shaped visual field defect in the same location in both eyes.


Central Visual Field Defect

Reduced or abnormal sight in the central visual field.


Peripheral visual field defect

Reduced or abnormal sight in the peripheral visual field.


Homonymous Visual Field Defect

A bilateral visual field defect on the same side of visual space of each eye (right or left).


Heteronymous Visual Field Defect

A bilateral visual field defect on opposite sides of the visual space of each eye (right or left).


Congruent Visual Field Defect

Identically shaped visual field defect in the same location in both eyes.


Conduction Abnormality and Atrioventricular Heart Block, CTCAE


Grade 1 Mobitz Type I, CTCAE

Asymptomatic, intervention not indicated


Grade 3 Sick Sinus Syndrome, CTCAE

Symptomatic, intervention indicated


Grade 3 Mobitz Type I, CTCAE

Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)


Grade 4 Conduction Abnormality NOS, CTCAE


Grade 5 Asystole, CTCAE

Death


Grade 1 Wolff-Parkinson-White Syndrome, CTCAE


Grade 2 Mobitz (Type) II Atrioventricular Block, CTCAE

Symptomatic; medical intervention indicated


Grade 1 Asystole, CTCAE

Periods of asystole; non-urgent medical management indicated


Grade 1 Mobitz (Type) II Atrioventricular Block, CTCAE


Grade 5 Wolff-Parkinson-White Syndrome, CTCAE


Grade 2 Conduction Abnormality NOS, CTCAE


Grade 3 Wolff-Parkinson-White Syndrome, CTCAE


Grade 5 Sick Sinus Syndrome, CTCAE

Death


Grade 5 Conduction Abnormality NOS, CTCAE


Grade 3 Conduction Abnormality NOS, CTCAE


Grade 4 Mobitz (Type) II Atrioventricular Block, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Conduction Abnormality NOS, CTCAE


Mobitz Type I, CTCAE

A disorder characterized by a dysrhythmia with a progressively lengthening PR interval prior to the blocking of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles.


Sick Sinus Syndrome, CTCAE

A disorder characterized by a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness.


Grade 2 Wolff-Parkinson-White Syndrome, CTCAE


Grade 2 Sick Sinus Syndrome, CTCAE

Symptomatic, intervention not indicated; change in medication initiated


Mobitz (Type) II Atrioventricular Block, CTCAE

A disorder characterized by a dysrhythmia with relatively constant PR interval prior to the block of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles.


Grade 4 Wolff-Parkinson-White Syndrome, CTCAE


Grade 5 Mobitz Type I, CTCAE

Death


Grade 3 Mobitz (Type) II Atrioventricular Block, CTCAE

Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker); new onset


Grade 5 Mobitz (Type) II Atrioventricular Block, CTCAE

Death


alpha-L-fructopyranose

A L-fructopyranose with an alpha-configuration at the anomeric position.


Small Intestinal Small Cell Neuroendocrine Carcinoma

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small intestine.  It is characterized by the presence of malignant small cells.


Grade 3 Lower Extremity Artery Injury, CTCAE


N-acylammonia

A carboxamide obtained by the formal condensation of the carboxy group of any carboxylic acid with ammonia.


A pyrazinecarboxamide in which a 6-oxo-1,6-dihydropyrazine nucleus is substituted on C-5 by a 4-hydroxyphenyl group and on C-2 by a butylcarbamyl group. A synthetic determinant of cefadroxil, it is a promising tool for determining in vitro cross-reactivity to cefadroxil in amoxicillin-allergic patients.


Acute Liver Injury without Fulminant Failure Related to COVID-19

Acute liver injury associated with abnormal liver chemistries (greater than two times the upper limit of normal) in the absence of signs of hepatic failure (e.g., no coagulopathy or encephalopathy) in a patient with probable or confirmed acute COVID-19. This is usually mild, transient, and does not require intervention.


Grade 5 Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pelvic Floor Muscle Weakness, CTCAE

Severe symptoms; limiting self care ADL


(S,S)-formoterol

An N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide in which both of the stereocentres have S configuration.


Moderate Cardiac Valve Stenosis

The cardiac valve orifice is abnormally narrow, to a moderate degree. (ACC)


Grade 5 Renal Hemorrhage, CTCAE

Death


Grade 5 Toxic Epidermal Necrolysis, CTCAE

Death


Hemorrhage of rectum and anus

Bleeding originating from the rectal wall and anus.


A benzamide obtained by formal condensation of the carboxy group of 5-chloro-2-methoxy-4-(methylamino)benzoic acid with the amino group of 1-benzyl-2-methylpyrrolidin-3-amine.


An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2.


Grade 2 Edema Limbs, CTCAE

>10-30% inter-limb discrepancy in volume or circumference at point of greatest visible difference; readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental ADL


Grade 3 Pancreatic Fistula, CTCAE

Invasive intervention indicated


Desmoplastic Neurotropic Melanoma

A desmoplastic melanoma characterized by the presence of nerve infiltration by atypical spindled melanocytes.


Ann Arbor Stage I AIDS-Related Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Magnesium ammonium phosphate urolithiasis

Urolithiasis in which the composition of the stone(s) is predominantly magnesium ammonium phosphate.


Grade 5 Bronchial Infection, CTCAE

Death


Stage IIIB Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 3 Cranial Nerve XI Neuropathy, CTCAE


Grade 3 Urethra Intra-Operative Injury, CTCAE


Stage IIIB Colon Cancer AJCC v8

Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage III Colon Cancer AJCC v8

Stage III includes: IIIA: (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIC Colon Cancer AJCC v8

Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIA Colon Cancer AJCC v8

Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Abdominal Pain, CTCAE

Mild pain


Abdominal Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the abdominal region.


Grade 2 Abdominal Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 3 Abdominal Pain, CTCAE

Severe pain; limiting self care ADL


Childhood Malignant Skin Neoplasm

A malignant neoplasm that affects the skin and occurs during childhood.


Grade 3 Testicular Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


diester

A diester is a compound containing two ester groups.


(R)-malathion

A diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate that is the R-enantiomer of malathion.


(S)-nisoldipine

A methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate that has S configuration.


(S)-malathion

A diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate that is the S-enantiomer of malathion.


(S)-bitolterol

The (S)-enantiomer of bitolterol.


(R)-nisoldipine

A methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate that has R configuration.


(R)-nicardipine

The R-enantiomer of nicardipine.


(R)-bitolterol

The (R)-enantiomer of bitolterol.


Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IIA includes: T1, N1, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Ectopic Meningioma

A meningothelial neoplasm that arises from an anatomic site outside the intracranial and intraspinal compartments.


Primary Middle Ear Meningioma

A rare extracranial meningioma that arises from the middle ear.


Primary Sinonasal Meningioma

A rare extracranial meningioma that arises from the sinonasal tract.


Grade 3 Seizure, CTCAE

New onset seizures (partial or generalized); multiple seizures despite medical intervention


Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Hepatic Artery Intra-Operative Injury, CTCAE


Grade 2 Trismus, CTCAE

Decreased ROM requiring small bites, soft foods or purees


Hodgkin's disease mixed cellularity stage II subdiaphragmatic


Ann Arbor Stage II Mixed Cellularity Classic Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Hodgkin's disease mixed cellularity stage II supradiaphragmatic


Childhood Sympathetic Paraganglioma

A sympathetic paraganglioma that occurs during childhood.


Childhood Paraganglioma

A paraganglioma that occurs during childhood.


Childhood Parasympathetic Paraganglioma

A parasympathetic paraganglioma that occurs during childhood.


Childhood Composite Paraganglioma

A composite paraganglioma that occurs during childhood.


Grade 1 Throat and Pharynx and Larynx Pain, CTCAE


delta-tocotrienol

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2 and 8 and a farnesyl chain at position 2.


chromanol

Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups.


(S,R,S)-alpha-tocopherol

The (S,R,S)-stereoisomer of alpha-tocopherol.


beta-tocotrienol

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5 and 8 and a farnesyl chain at position 2. It has been isolated from various cultivars of wheat.


(R,R,S)-alpha-tocopherol

The (R,R,S)-stereoisomer of alpha-tocopherol.


alpha-tocopherol

A tocopherol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a 4,8,12-trimethyltridecyl group at position 2.


gamma-tocopherol

A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.


delta-tocopherol

A tocopherol in which the chroman-6-ol core is substituted by a methyl group at position 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.


(S,S,R)-alpha-tocopherol

The (S,S,R)-stereoisomer of alpha-tocopherol.


(R,S,R)-alpha-tocopherol

The (R,S,R)-stereoisomer of alpha-tocopherol.


tocol

A chromanol with a chroman-6-ol skeleton that is substituted at position 2 by a saturated or triply-unsaturated hydrocarbon chain consisting of three isoprenoid units.


tocopherol

A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.


alpha-tocotrienol

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a farnesyl chain at position 2. It has been found in palm oil derived from Elaeis guineensis.


beta-tocopherol

A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 5 and 8. While it is found in low concentrations in many vegetable oils, only cottonseed oil contains significant amounts.


(S,S,S)-alpha-tocopherol

The (S,S,S)-stereoisomer of alpha-tocopherol.


(S,R,R)-alpha-tocopherol

The (S,R,R)-stereoisomer of alpha-tocopherol.


(R,S,S)-alpha-tocopherol

The (R,S,S)-stereoisomer of alpha-tocopherol.


gamma-tocotrienol

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2. A vitamin E family member that has potent anti-cancer properties against a wide-range of cancers.


Mismatch Repair-Deficient Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by mismatch repair (MMR) deficiency caused by inactivating methylation or less frequently mutation of an MMR gene (MLH1, PMS2, MSH2, or MSH6).


Grade 2 Kidney Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stent restenosis

Fifty percent or greater stenosis within an existing stent. (ACC)


Uterine Corpus Neuroendocrine Tumor G1

A very rare and well-differentiated neuroendocrine tumor that arises from the uterine corpus.


Stress ulcer

An ulcer due to stress.


Connective and Soft Tissue

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The supporting connective tissue of an organ.


soft tissue

A general term comprising tissue that is not hardened or calcified; including muscle, fat, blood vessels, nerves, tendons, ligaments and fascia.


bone tissue

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.


connective tissue

Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.


Malignant neoplasm of exocervix

A malignant neoplasm that affects the exocervix.


Grade 5 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Superior Vena Cava Vein Injury, CTCAE


carboxamidine

Compounds having the structure RC(=NR)NR2. The term is used as a suffix in systematic nomenclature to denote the -C(=NH)NH2 group including its carbon atom.


formamidines

Amidines with the general formula R(1)N=CHNR(2)R(3) (R(1), R(2), R(3) can be H).


Grade 1 Wrist Fracture, CTCAE

Mild; non-operative intervention indicated


Grade 5 Anus Stricture or Stenosis, CTCAE


Grade 3 Erythroderma, CTCAE

Erythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self care ADL


Erythroderma, CTCAE

A disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area.


Grade 4 Erythroderma, CTCAE

Erythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated


Grade 2 Erythroderma, CTCAE

Erythema covering >90% BSA without associated symptoms; limiting instrumental ADL


Grade 5 Erythroderma, CTCAE

Death


Genital Human Papillomavirus Infection

Infection of the genitalia by human papillomavirus.


Iatrogenic Hypoparathyroidism

Hypoparathyroidism resulting from medical treatment or intervention.


Acquired Hypoparathyroidism

Hypoparathyroidism, the cause of which is not present at birth.


Hypoparathyroidism, Autosomal Recessive

Hypoparathyroidism associated with homozygous mutation(s) in the PTH gene, which encodes parathyroid hormone, or in the GCM2 gene, which encodes chorion-specific transcription factor GCMb.


Transient neonatal hypoparathyroidism

A disorder of decreased production of parathyroid hormone by the parathyroid gland in a newborn. It is due to maternal hyperparathyroidism. It may be characterized by hypocalcemic seizures in the first weeks of life.


Primary hypoparathyroidism

Abnormally low levels of parathyroid hormone due to a disorder originating within the parathyroid glands.


Grade 4 Fibrosis-Deep Connective Tissue, CTCAE


Circumscribed storiform collagenoma

A benign skin tumor characterized as a small, dome-shaped dermal nodule composed of fibroblasts in a dense collagenous background with storiform organization.  Rarely, multiple lesions can occur in connection with Cowden's disease.


Senile nevus

A benign skin lesion consisting of a cluster of capillaries at the surface of the skin, forming a red papular lesion.


chlorobenzophenone

A member of the class of benzophenones that is any substituted benzophenone in which at least one of the substituents is a chlorine.


organosilicon compound

An organosilicon compound is a compound containing at least one carbon-silicon bond.


organosiloxane

A siloxane where Si is substituted with organyl groups.


Grade 2 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Feeding Intolerance, AE

An adverse event in a newborn characterized by mild feeding intolerance (e.g. increased gastric residual volume or abdominal distension); without discomfort; no change in care indicated.


Elevated AFP-L3

A finding indicating that elevated concentrations of alpha-fetoprotein (AFP) fraction L3 (AFP-L3) were detected in a sample. AFP-L3 represents a glycoform variant of AFP that is highly reactive with Lens culinaris-expressed agglutinin (LCA) due to the presence of an extra alpha-(1-6) fucose attached to the N-acetylglucosamine modification present in AFP.


AFP Level Finding

A finding that indicates the amount of alpha-fetoprotein tumor marker in a sample.


anilines

Any  aromatic amine that is benzene carrying at least one amino substituent and its substituted derivatives.


(R)-mosapride

A 4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide that has (R)-configuration.


(R)-aminoglutethimide

The (3R)-enantiomer of aminoglutethimide.


(S)-mosapride

A 4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide that has (S)-configuration.


fluorenes

An ortho-fused polycyclic arene in which the skeleton is composed of two benzene rings ortho-fused to cyclopentane.


Primary Insomnia

A sleep disorder characterized by difficulty initiating or maintaining sleep; this difficulty does not occur in the context of another sleep disorder and is not etiologically linked to a mental disorder, substance use, or a general medical condition.


tetrol

A polyol that contains 4 hydroxy groups.


A hydroxycalciol that is a synthetic fluorinated and deuterated analogue of vitamin D3 which exhibits vitamin D receptor superagonist and anti-cancer activity.


1alpha,23(S),25-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) bearing additional hydroxy substituents at positions 1, 23 and 25 (with 1alpha,23S-configuration). An intermediate in the degradation pathway of 1alpha,25-(OH)2D3.


(20S,23,24)-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration), 23 and 24.


A vitamin D that is 19-norcalcitriol carrying an additional 3-hydroxypropyl substituent at position 2. A synthetic analogue of vitamin D, it exhibits anticancer properties.


nordihydroguaiaretic acid

A tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups. Masoprocol, the meso-form found in the leaves of the creosote bush (Larrea divaricata), is a potent lipoxygenase inhibitor.


(20S,23,25)-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration), 23 and 25.


A hydroxycalciol that is calcitriol with a 4-hydroxybutoxy group at position 2.


Cor triloculare

A congenital anatomic anomaly in which the heart has only three chambers.


Grade 5 Urostomy Leak, CTCAE

Death


Splenic Manifestation of Chronic Lymphocytic Leukemia

Infiltration of the spleen by chronic lymphocytic leukemia. It primarily involves the white pulp.


Kaposi's sarcoma of oral cavity

Kaposi sarcoma arising from the oral cavity.


Parotid Gland Lipoma

A lipoma that arises from the parotid gland.


Grade 1 Irregular Menstruation, CTCAE

Intermittent/irregular menses for no more than 3 consecutive menstrual cycles


pyrazine

A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.


An  oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.


Grade 3 Headache, CTCAE

Severe pain; limiting self care ADL


Headache, CTCAE

A disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve.


Grade 1 Headache, CTCAE

Mild pain


Grade 2 Headache, CTCAE

Moderate pain; limiting instrumental ADL


Gastric Anastomotic Leakage

Leakage due to breakdown of a gastric anastomosis.


azulenes

Any carbobicyclic compound whose skeleton consists of a cyclopentane ring ortho-fused to a cycloheptane ring.


Ann Arbor Stage I Lymphocyte-Depleted Classic Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Ann Arbor Stage I Supradiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


Ann Arbor Stage I Subdiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


Diaper candidiasis

An inflammatory skin condition in the diaper area superimposed with Candida infection, characterized by a bright red rash with a sharply demarcated edge and satellite lesions. Skin folds are often involved.


Grade 4 Arachnoiditis, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage IB Adult Soft Tissue Sarcoma AJCC v7


Grade 3 Skin Breakdown or Decubitus Ulcer, CTCAE


Grade 3 Anal Pain, CTCAE

Severe pain; limiting self care ADL


Grade 1 Pyramidal Tract Dysfunction, CTCAE


Congenital anomaly of tricuspid valve

A defect of the tricuspid valve present at birth.


Midgut Neuroendocrine Tumor G1

A well-differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the jejunum, ileum, proximal colon, or appendix. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Meckel Diverticulum Neuroendocrine Tumor G1

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises in a Meckel diverticulum.


Metastatic Midgut Neuroendocrine Tumor G1

A midgut neuroendocrine tumor G1 that has spread from its original site of growth to another anatomic site.


Locally Advanced Digestive System Neuroendocrine Tumor G3

Digestive system neuroendocrine tumor G3 that has spread from its original site of growth to nearby tissues or lymph nodes.


Psoralen and long-wave ultraviolet radiation (PUVA) keratosis

A hyperkeratotic skin lesion that occurs in patients with a history of prolonged exposure to psoralen and ultraviolet A (PUVA) therapy.


Grade 5 Intestinal Stoma Obstruction, CTCAE

Death


Grade 3 Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


L-mannitol

The L-enantiomer of mannitol.


Oral Cavity Mucosal Melanoma

A rare melanoma that arises from the oral cavity. It is associated with a poor prognosis.


Childhood Posterior Fossa Ependymoma

A posterior fossa ependymoma that occurs during childhood.


Neonatal Tachyarrhythmia, AE

An adverse event in a newborn characterized by non-sinus rhythm with an abnormally high heart rate for age.


Grade 4 Neonatal Tachyarrhythmia, AE

A tachyarrhythmia adverse event in a newborn characterized by life-threatening consequences (e.g. shock); requiring urgent major care changes.


Grade 5 Neonatal Tachyarrhythmia, AE

A tachyarrhythmia adverse event in a newborn which results in death.


Grade 3 Neonatal Tachyarrhythmia, AE

A tachyarrhythmia adverse event in a newborn resulting in non-life threatening hemodynamic compromise or changes in age-appropriate behavior; requiring major care changes (e.g. new medication or intervention).


Grade 2 Neonatal Tachyarrhythmia, AE

A tachyarrhythmia adverse event in a newborn characterized by no change in age-appropriate behavior; requiring minor care changes (e.g. increased monitoring).


Grade 1 Neonatal Tachyarrhythmia, AE

An adverse event in a newborn characterized by brief, self-limiting, episodes of asymptomatic tachyarrhythmia (e.g. extra-systolic beats); no care changes.


Adult Benign Brain Stem Neoplasm

A benign neoplasm of the brain stem occurring in adults.


Medullary Hemangioblastoma

A hemangioblastoma that arises from the medulla oblongata.


Childhood Brain Stem Gliosarcoma

A gliosarcoma that arises from the brain stem and occurs during childhood.


Recurrent Childhood Brain Stem Astrocytoma

The reemergence of brain stem astrocytoma in childhood after a period of remission.


Childhood Brain Stem Mixed Glioma

A mixed glioma that arises from the brain stem and occurs during childhood.


Metastatic malignant neoplasm to brain stem

A malignant neoplasm that has spread from its original site of growth to the brain stem.


Recurrent Childhood Brain Stem Glioma

The reemergence of brain stem glioma in childhood after a period of remission.


Anaplastic Brain Stem Astrocytoma

An anaplastic astrocytoma that arises from the brain stem.


Brain Stem Glioblastoma

A glioblastoma that arises from the brain stem.


Anaplastic Brain Stem Glioma

An anaplastic glioma that arises from the brain stem.


Grade 5 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Recurrent Acute Bilineal Leukemia

The reemergence of acute bilineal leukemia after a period of remission.


Recurrent Mixed Phenotype Acute Leukemia

The reemergence of mixed phenotype acute leukemia after a period of remission.


acute biphenotypic leukemia in relapse

The reemergence of acute biphenotypic leukemia after a period of remission.


Grade 4 Oral Cavity NOS Intra-Operative Injury, CTCAE


Grade 3 Glaucoma, CTCAE

EIOP causing visual field deficits


Grade 4 Hypomagnesemia, CTCAE

<0.7 mg/dL; <0.3 mmol/L; life-threatening consequences


Ampulla of Vater Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The Ki-67 index is higher than 20%.


Low Risk Small Intestinal Gastrointestinal Stromal Tumor


Low Risk Esophageal Gastrointestinal Stromal Tumor


Low Risk Colorectal Gastrointestinal Stromal Tumor


Low Risk Gastric Gastrointestinal Stromal Tumor


Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form thin-branching papillae and exhibit high grade dysplasia.


Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that are similar to gastric foveolar epithelial cells.


Branch Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

An intraductal papillary-mucinous neoplasm of the pancreas that arises in one of the branches of the main pancreatic duct.  It usually has an indolent behavior.


Mixed Type Pancreatic Intraductal Papillary-Mucinous Neoplasm

An intraductal papillary-mucinous neoplasm of the pancreas that arises primarily from the main pancreatic duct and extends to the branch ducts.


Pancreatic Intraductal Papillary Mucinous Neoplasm, Oncocytic-Type

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells with abundant eosinophilic granular cytoplasm.


Main Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

An intraductal papillary-mucinous neoplasm of the pancreas that arises from the main pancreatic duct.


Pancreatic Intraductal Papillary Mucinous Neoplasm, Intestinal-Type

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form tall papillae, similar to those that are present in colonic villous adenomas.


Advanced Rhabdoid Tumor

Rhabdoid tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Rhabdoid Tumor

A rhabdoid tumor that has spread from the original site of growth to another anatomic site.


sialadenoma papilliferum of salivary gland

An uncommon exophytic papillary proliferation that involves mucosal surface epithelium and salivary duct epithelium. It is exceptional among salivary gland neoplasms because it manifests as an exophytic papillary excrescence of the mucosa, rather than as a submucosal or intraglandular mass. It most often affects the hard or soft palate.  It is generally asymptomatic.


aurachin C

A C-type aurachin that is quinolin-4-one which is substituted by a hydroxy group at positions 1, a methyl group at position 2, and a triprenyl group at position 3.


Elevated Sedimentation Rate

A higher than average sedimentation rate in a sample.


Low Grade Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is low grade.


Grade 1 Genital Edema, CTCAE

Mild swelling or obscuration of anatomic architecture on close inspection


Grade 1 Bruising in the Absence of Grade 3 or Grade 4 Thrombocytopenia, CTCAE


Tentorial Tear Related to Birth

Disruption of the tentorium cerebelli incurred during delivery.


Grade 2 Pericardial Effusion, CTCAE

Asymptomatic effusion size small to moderate


Classic Hydroa Vacciniforme Lymphoproliferative Disorder

Hydroa vacciniforme lymphoproliferative disorder characterized by the presence of self-limited papulovesicular skin lesions in sun-exposed areas. There is no involvement of internal organs. It has an indolent course and usually affects White individuals.


Stage II Childhood Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Carsickness

A sensation of discomfort associated with ground travel; symptoms may include nausea, vomiting, dizziness or sweating.


Grade 1 Appendix Intra-Operative Injury, CTCAE


Refractory Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that does not respond to treatment.


Refractory Head and Neck Squamous Cell Carcinoma

A head and neck squamous cell carcinoma that does not respond to treatment.


Refractory Sinonasal Squamous Cell Carcinoma

Nasal cavity and paranasal sinus squamous cell carcinoma that does not respond to treatment.


Refractory Oral Cavity Squamous Cell Carcinoma

Oral cavity squamous cell carcinoma that does not respond to treatment.


Refractory Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that does not respond to treatment.


Hodgkin's lymphoma of small intestine

A Hodgkin lymphoma that arises from the small intestine.


Resectable Pancreatic Acinar Cell Carcinoma

Pancreatic acinar cell carcinoma that is amenable to surgical resection.


Pancreas carcinoma resectable

Carcinoma of the pancreas amenable to surgical removal.


Borderline Resectable Pancreatic Ductal Adenocarcinoma

A pancreatic ductal adenocarcinoma term that refers to a continuum between resectable and locally advanced unresectable disease.


Pancreatic adenocarcinoma resectable

Pancreatic adenocarcinoma that is amenable to surgical resection.


Resectable Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma amenable to surgical resection.


Resectable Pancreatic Adenosquamous Carcinoma

Pancreatic adenosquamous carcinoma that is amenable to surgical resection.


Stage I Lip and Oral Cavity Cancer AJCC v8

Stage I includes: T1, N0, M0.  T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less depth of invasion (DOI).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


Grade 2 Parotid Gland Intra-Operative Injury, CTCAE


Hemolytic anemia due to disseminated intravascular coagulation


Anemia due to membrane defect

A group of inherited hemolytic anemias caused by erythrocyte membrane defects. This includes hereditary pyropoikilocytosis, hereditary spherocytosis and hereditary elliptocytosis.


Immune Hemolytic Anemia

An acquired anemia resulting from immune-mediated destruction of the red blood cells. Causes include autoimmune disorders, blood transfusions, and drugs.


Infantile pyknocytosis

A rare, neonatal syndrome characterized by early jaundice that becomes rapidly associated with severe hemolytic anemia. The peripheral blood smear is remarkable for small irregular, contracted red blood cells with hyper-dense spikes (pyknocytes), that progressively increase in number and then spontaneously disappear.


Angiocentric immunoproliferative lesion grade 2

Lymphomatoid granulomatosis characterized by the presence of occasional large lymphoid cells or immunoblasts in a polymorphous background. Necrosis is more commonly seen as compared to grade I lymphomatoid granulomatosis. By in situ hybridization, EBV-positive cells are readily seen.


Central Nervous System Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis that affects the brain, spinal cord, and leptomeninges.


Cutaneous Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis that affects the skin.


Childhood Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis that occurs during childhood.


Grade 2 Fallopian Tube Obstruction, CTCAE

Symptomatic; elective intervention indicated


Fallopian Tube Obstruction, CTCAE 5.0

A disorder characterized by blockage of the normal flow of the contents in the fallopian tube.


Grade 1 Fallopian Tube Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Fallopian Tube Obstruction, CTCAE

Severe symptoms; invasive intervention indicated


High Grade Anal Canal Intraepithelial Neoplasia

Intraepithelial neoplasia involving the anal canal.  The epithelial cells exhibit moderate dysplasia (grade II intraepithelial neoplasia) or severe dysplasia (grade III intraepithelial neoplasia or carcinoma in situ).


diphenylethane

Compounds containing two phenyl groups connected by an ethyl linker.


benzoins

An aromatic ketone containing a benzoin (2-hydroxy-1,2-diphenylethanone) skeleton.


HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 6

A lipid transport disorder characterized by extremely elevated levels of high density lipoprotein cholesterol (HDL C; HDLC). It is caused by heterozygous mutations in the SCARB1 gene that result in decreased transport of HCL C into the liver by scavenger receptor class B member 1.


Grade 3 Upper Extremity Vein Injury, CTCAE


carbonate ester

Any carbonate that is carbonic acid in which the hydrogens have been replaced by organyl groups.


Grade 4 Sinusoidal Obstruction Syndrome, CTCAE

Life-threatening consequences (e.g., ventilatory support, dialysis, plasmapheresis, peritoneal drainage)


(S)-salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has S configuration.


(R)-salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has R configuration.


Refractory Neuroblastoma

A neuroblastoma that does not respond to treatment.


Reactive Hyperplasia of the Retinal Pigment Epithelium

A reactive, non-neoplastic hyperplasia of the retinal pigment epithelium.


Grade 3 Neuroendocrine ACTH Deficiency, CTCAE


CPK Increased, CTCAE

A finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen.


Grade 4 CPK Increased, CTCAE

>10 x ULN


Grade 1 CPK Increased, CTCAE

>ULN-2.5 x ULN


Grade 2 CPK Increased, CTCAE

>2.5 x ULN-5 x ULN


Grade 2 Ovarian Infection, CTCAE

Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 5 Cranial Nerve VI Neuropathy, CTCAE


Grade 2 Bone Infection with Unknown Absolute Neutrophil Count, CTCAE


Bone Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Bone Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Bone Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Bone Infection with Unknown Absolute Neutrophil Count, CTCAE


Iris Implantation Cyst

A cyst that arises from the iris and is lined by squamous epithelium.


Grade 2 Neonatal Pneumothorax, AE

An adverse event in a newborn characterized by radiological evidence of pneumothorax; minor clinical signs; minor care change required (e.g. oxygen, increased monitoring).


Grade 2 Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Excessive Bleeding

Abnormally heavy or prolonged loss of blood.


Non-toxic multinodular goiter

A multinodular goiter that is not associated with changes in thyroid function or malignancy.


Multinodular Endemic Goiter

A multinodular goiter caused by inadequate iodine intake.


Adult Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm, occurring in adults.  It is characterized by a proliferation of neoplastic spindle cells.


Penile Leiomyosarcoma

A leiomyosarcoma that occurs in the penis.


Unresectable Leiomyosarcoma

A leiomyosarcoma which is not amenable to surgical resection.


Dedifferentiated Leiomyosarcoma

A pleomorphic leiomyosarcoma that lacks immunohistochemical staining for myogenic markers in the pleomorphic areas.


Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Pancreatic Leiomyosarcoma

A rare leiomyosarcoma that arises from the pancreas.


Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8

Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage I Uterine Corpus Leiomyosarcoma AJCC v8

Stage I includes: T1, N0, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IV Uterine Corpus Leiomyosarcoma AJCC v8

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus leiomyosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Primary leiomyosarcoma

Leiomyosarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


EBV-Related Leiomyosarcoma

Leiomyosarcoma that is caused by Epstein-Barr virus infection.


Inferior Vena Cava Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm, arising from the inferior vena cava.  It is characterized by a proliferation of neoplastic spindle cells.


Metastatic leiomyosarcoma

A leiomyosarcoma that has spread to other anatomic sites.


leiomyosarcoma of appendix

A rare leiomyosarcoma that arises from the appendiceal wall.


Unresectable Soft Tissue Leiomyosarcoma

A soft tissue leiomyosarcoma that is not amenable to surgical resection.


Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8

Stage IVA includes: T4, Any N, M0. T4: Uterine corpus leiomyosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Conjunctival Leiomyosarcoma

A leiomyosarcoma that arises from the conjunctiva.


Seminal Vesicle Leiomyosarcoma

A rare leiomyosarcoma that affects the seminal vesicle.


Stage IB Uterine Corpus Leiomyosarcoma AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Uterine corpus leiomyosarcoma with tumor limited to the uterus, measuring more than 5 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Pleomorphic leiomyosarcoma

A leiomyosarcoma characterized by the presence of poorly differentiated areas with pleomorphic appearance, in addition to areas with typical morphologic features.


Leiomyosarcoma NCI Grade 2

A leiomyosarcoma with less than 15% necrosis.


Refractory Leiomyosarcoma

Leiomyosarcoma that does not respond to treatment.


Leiomyosarcoma of Vessels

An aggressive malignant smooth muscle neoplasm, arising from the walls of the vascular system.  It is characterized by a proliferation of neoplastic spindle cells.


leiomyosarcoma of bladder

A leiomyosarcoma that arises from the bladder. It is the most common type of bladder sarcoma in adults.


Broad Ligament Leiomyosarcoma

A rare leiomyosarcoma that arises from the broad ligament.


Unresectable Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that is not amenable to surgical resection.


Advanced Soft Tissue Leiomyosarcoma

A soft tissue leiomyosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8

Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Uterine Corpus Leiomyosarcoma by AJCC v8 Stage

A term that refers to the staging of uterine corpus leiomyosarcoma according to the American Joint Committee on Cancer, 8th edition.


Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8

Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. T2: Uterine corpus leiomyosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Childhood Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm, occurring in children.  It is characterized by a proliferation of neoplastic spindle cells.


Leiomyosarcoma recurrent

The reemergence of leiomyosarcoma after a period of remission


Locally Recurrent Uterine Corpus Leiomyosarcoma

The reemergence of uterine corpus leiomyosarcoma after a period of remission, at or adjacent to the site of the original tumor.


Stage III Uterine Corpus Leiomyosarcoma AJCC v8

Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. T2: Uterine corpus leiomyosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Thyroid Gland Leiomyosarcoma

A leiomyosarcoma that arises from the thyroid gland.


Metastatic Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that has spread from its original site of growth to another anatomic site.


Locally Advanced Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that has spread to nearby tissues or lymph nodes.


Colorectal Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm that arises from the colon or rectum.  It is characterized by a proliferation of neoplastic spindle cells.


Metastatic Soft Tissue Leiomyosarcoma

A soft tissue leiomyosarcoma that has spread from the original site of growth to another anatomic site.


Sinonasal Leiomyosarcoma

A leiomyosarcoma that arises from the nasal cavity and paranasal sinuses.


Well Differentiated Leiomyosarcoma

Grade I malignant smooth muscle neoplasm.  It is characterized by a proliferation of neoplastic spindle cells.


Stage IA Uterine Corpus Leiomyosarcoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Uterine corpus leiomyosarcoma with tumor limited to the uterus, measuring 5 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Digestive System Leiomyosarcoma

A leiomyosarcoma arising from an anatomic site in the digestive system.


Resectable Leiomyosarcoma

Leiomyosarcoma that is amenable to surgical resection.


Advanced Leiomyosarcoma

A leiomyosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Soft Tissue Leiomyosarcoma

Soft tissue leiomyosarcoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Leiomyosarcoma

A leiomyosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Leiomyosarcoma of Deep Soft Tissue

A rare leiomyosarcoma that arises from the deep soft tissue in the retroperitoneum or abdominal cavity.


Grade 4 Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Aortic Injury, CTCAE

Operative intervention not indicated


Refractory Malignant Soft Tissue Neoplasm

Malignant soft tissue neoplasm that is resistant to treatment.


Refractory Extrarenal Rhabdoid Tumor

Extrarenal rhabdoid tumor that is  resistant to treatment.


Digestive System Solitary Fibrous Tumor

A solitary fibrous tumor arising from an anatomic site in the digestive system, including the esophagus, gallbladder, liver, pancreas, small bowel mesentery, and the serosal surfaces of the stomach and colon.


Skin tumor of smooth muscle origin

A smooth muscle neoplasm occurring in the skin.


Pilar Leiomyoma

A cutaneous leiomyoma arising from the arrector pili muscle.


Refractory Paraganglioma

A paraganglioma that does not respond to treatment.


Refractory Adrenal Gland Pheochromocytoma

A pheochromocytoma that does not respond to treatment.


Stage IB Uterine Corpus Cancer AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Uterine corpus carcinoma or carcinosarcoma with tumor invading one half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


A member of the class of benzofurans consisting of a 1-benzofuran skeleton and its substituted derivatives thereof.


hydroxybenzoic acid

Any benzoic acid carrying one or more phenolic hydroxy groups on the benzene ring.


3-hydroxyanthranilic acid

An  aminobenzoic acid that is benzoic acid substituted at C-2 by an amine group and at C-3 by a hydroxy group. It is an intermediate in the metabolism of the amino acid tryptophan.


3-amino-5-hydroxybenzoic acid

A monohydroxybenzoic acid that is 3-hydroxybenzoic acid carrying an additional amino substitutent at position 4.


3-amino-4-hydroxybenzoic acid

A monohydroxybenzoic acid that is 4-hydroxybenzoic acid carrying an additional amino substitutent at position 3.


3-amino-2,4-dihydroxybenzoic acid

An aminobenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 4, and by an amino group at position 3.


cannabidiolic acid

A dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a 3-p-mentha-1,8-dien-3-yl (limonene) group.


monohydroxybenzoic acid

Any hydroxybenzoic acid having a single phenolic hydroxy substituent on the benzene ring.


3-hydroxy-4-methylanthranilic acid

An aminobenzoic acid that is anthranilic acid substituted by a hydroxy group at position 3 and a methyl group at position 4.


dihydroxybenzoic acid

Any member of the class of  hydroxybenzoic acids carrying  two phenolic hydroxy groups on the benzene ring and its derivatives.


Beta-Catenin-Activated Inflammatory Hepatocellular Adenoma

Hepatocellular adenoma with features of both beta-catenin-activated hepatocellular adenoma and inflammatory hepatocellular adenoma.


mahuannin D

A proanthocyanidin isolated form Ephedra sinica.


proanthocyanidin

A flavonoid oligomer obtained by the the condensation of two or more units of hydroxyflavans.


arecatannin a2

a class of condensed tannins in the sub-class procyanidins contained in the seeds of Areca catechu also called betel nut. The arecatannin-type natural products from Ceylonese cassia bark and Areca seed are examples polyphenols by both current definitions, and fit the distinct definition of a polymeric phenol as well.


procyanidin B8

A proanthocyanidin that is (+)-catechin and (-)-epicatechin units joined by a bond between positions 4 and 6' respectively in an alpha-configuration. Procyanidin B8 is found in acorn and is present in fruit and leaves of blackberry (Rubus fruticosus), raspberry (Rubus idaeus) and cowberry (Vaccinium vitis idaea). It can be also found in grape seeds and in beer.


A proanthocyanidin consisting of (-)-epigallocatechin and (-)-epicatechin units joined by a (4beta->8)-linkage.


proanthocyanidin A2

A proanthocyanidin obtained by the condensation of (-)-epicatechin units.


A proanthocyanidin consisting of (+)-catechin and (+)-gallocatechin units joined by a (4alpha->6)-linkage.


A proanthocyanidin consisting of (+)-gallocatechin and (-)-epicatechin units joined by a (4alpha->8)-linkage.


cinnamtannin A2

A proanthocyanidin isolated from Cinnamomum cassia.


procyanidin B4

A proanthocyanidin obtained by the condensation of (-)-epicatechin and (+)-catechin units.


parameritannin A-1

A  proanthocyanidin  found in Cinnamomum cassia and Parameria laevigata.


A proanthocyanidin that is a doubly linked dimer composed of (-)-epicatechin and (-)-epigallocatechin as its flavanol units. Isolated from the wood of Xanthoceras sorbifolium, it exhibits inhibitory activity towards HIV-1 protease.


A proanthocyanidin consisting of (+)-gallocatechin and (+)-catechin units joined by a (4beta->8)-linkage.


A proanthocyanidin consisting of (+)-gallocatechin and (+)-catechin units joined by a (4alpha->6)-linkage.


A proanthocyanidin consisting of two molecules of (-)-epicatechin joined by a (4alpha->8)-linkage.


A proanthocyanidin consisting of (-)-epicatechin and (-)-epigallocatechin units joined by a (4beta->8)-linkage.


A proanthocyanidin consisting of (-)-epicatechin and (+)-gallocatechin units joined by a (4beta->8)-linkage.


A proanthocyanidin consisting of (+)-catechin and (-)-epigallocatechin units joined by a (4alpha->8)-linkage.


procyanidin

oligomeric compounds, formed from catechin and epicatechin molecules. They yield cyanidin when depolymerized under oxidative conditions.


A proanthocyanidin consisting of (-)-epigallocatechin and (+)-catechin units joined by a (4alpha->6)-linkage.


A biflavonoid consisting of two molecules of afzelechin joined by a (4alpha->8) linkage.


procyanidin C1

A proanthocyanidin consisting of three (-)-epicatechin units joined by two successive (4beta->8)-linkages.


procyanidin B5

A proanthocyanidin  consisting of two molecules of (-)-epicatechin joined by a bond between positions 4 and 6' in beta-configuration. It can be found in grape seeds, in Hibiscus cannabinus (kenaf) root and bark, in apple and in cacao.


procyanidin B2

A proanthocyanidin consisting of two molecules of (-)-epicatechin joined by a bond between positions 4 and 8' in a beta-configuration. Procyanidin B2 can be found in Cinchona pubescens (Chinchona, in the rind, bark and cortex), in Cinnamomum verum (Ceylon cinnamon, in the rind, bark and cortex), in Crataegus monogyna (Common hawthorn, in the flower and blossom), in Uncaria guianensis (Cat's claw, in the root), in Vitis vinifera (Common grape vine, in the leaf), in Litchi chinensis (litchi, in the pericarp), in the apple, in Ecdysanthera utilis and in red wine.


A  proanthocyanidin isolated from Cinnamomum cassia.


arecatannin B1

A proanthocyanidin consisting of two (-)-epicatechin and one (+)-catechin units joined in sequence by (4beta->8)- and (4beta->6)-linkages.


A proanthocyanidin consisting of (+)-gallocatechin and (+)-catechin units joined by a (4alpha->8)-linkage.


dracorubin

A proanthocyanidin isolated from Dracaena draco.


procyanidin B1

A proanthocyanidin consisting of (-)-epicatechin and (+)-catechin units joined by a bond between positions 4 and 8' respectively  in a beta-configuration.. Procyanidin B1 can be found in Cinnamomum verum (Ceylon cinnamon, in the rind, bark or cortex), in Uncaria guianensis (cat's claw, in the root), and in Vitis vinifera (common grape vine, in the leaf) or in peach.


cassiatannin A

A   proanthocyanidin isolated from the bark of Cinnamomum cassia.


procyanidin B3

A proanthocyanidin consisting of two molecules of (+)-catechin joined by a bond between positions 4 and 8' in alpha-configuration. It can be found in red wine, in barley, in beer, in peach or in Jatropha macrantha, the Huanarpo Macho.


cinnamtannin B-1

A  proanthocyanidin found in Cinnamomum cassia and Cinnamomum zeylanicum.


procyanidin B6

A proanthocyanidin consisting of two molecules of (+)-catechin joined by a bond between positions 4 and 6' in alpha-configuration. Procyanidin B6 is isolated from leaves and fruit of cowberry Vaccinium vitis-idaea and other plants. It can also be found in grape seeds and in beer.


cinnamtannin D-1

A proanthocyanidin found in Cinnamomum cassia.


Grade 3 Nausea, CTCAE

Inadequate oral caloric or fluid intake; tube feeding, TPN, or hospitalization indicated


Nausea, CTCAE 5.0

A disorder characterized by a queasy sensation and/or the urge to vomit.


Grade 2 Nausea, CTCAE

Oral intake decreased without significant weight loss, dehydration or malnutrition


Grade 1 Nausea, CTCAE

Loss of appetite without alteration in eating habits


Grade 3 Infusion Site Extravasation, CTCAE

Ulceration or necrosis; severe tissue damage; operative intervention indicated


Acute esophagitis

An acute inflammatory process affecting the esophageal wall.


Precocious Puberty, CTCAE 5.0

A disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys.


Grade 2 Precocious Puberty, CTCAE

Physical signs and biochemical markers of puberty for females <8 years and males <9 years


Grade 1 Precocious Puberty, CTCAE

Physical signs of puberty with no biochemical markers for females <8 years and males <9 years


Refractory Rhabdoid Tumor of the Kidney

A rhabdoid tumor of the kidney that does not respond to treatment.


Recurrent Rhabdoid Tumor of the Kidney

The reemergence of a rhabdoid tumor of the kidney after a period of remission.


Unresectable Rhabdoid Tumor of the Kidney

Rhabdoid tumor of the kidney that is not amenable to surgical resection.


Gastrointestinal stromal tumor, benign

A gastrointestinal stromal tumor that is characterized by a maximum diameter equal or less than 5 cm (gastric localization), or equal or less than 2 cm (intestinal localization) and no more than 5 mitotic figures per 50 high power fields.


Benign Gastric Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor arising from the stomach.  It is characterized by a maximum diameter equal or less than 5 cm and no more than 5 mitotic figures per 50 high power fields.


Stage IA Hepatocellular Carcinoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Solitary tumor equal to or less than 2 cm.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage I Hepatocellular Carcinoma AJCC v8

Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0). T1a: Solitary tumor equal to or less than 2 cm.  T1b: Solitary tumor larger than 2 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IB Hepatocellular Carcinoma AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Solitary tumor larger than 2 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Atelectasis, CTCAE

Supplemental oxygen indicated; hospitalization or elective operative intervention indicated (e.g., stent, laser)


inorganic potassium salt

A potassium salt that lacks C-H bonds


potassium salt

Any alkali metal salt having potassium(1+) as the cation.


Breast Myoid Hamartoma

A breast hamartoma characterized by the predominance of a smooth muscle component.


Grade 2 Dental and Teeth and Peridontal Pain, CTCAE


Grade 2 Dehydration, CTCAE

IV fluids indicated


Dehydration, CTCAE

A disorder characterized by excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis.


Grade 5 Dehydration, CTCAE

Death


Grade 4 Dehydration, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Dehydration, CTCAE

Increased oral fluids indicated; dry mucous membranes; diminished skin turgor


Grade 3 Dehydration, CTCAE

Hospitalization indicated


Grade 5 Abdomen Soft Tissue Necrosis, CTCAE


Colorectal Microvesicular Hyperplastic Polyp

A serrated hyperplastic polyp that arises from the colon and rectum.  It is characterized by the presence of microvacuolated columnar cells that are admixed with small numbers of goblet cells.  There is no evidence of epithelial atypia or dysplasia.


Refractory Visual Pathway Glioma

Visual pathway glioma that is resistant to treatment.


Stage II Gastric Neuroendocrine Tumor AJCC v8

Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Dysembryoplastic Neuroepithelial-Like Tumor of the Septum Pellucidum

A very rare, low-grade midline brain neoplasm that affects the septum pellucidum. It is characterized by similar histological features to those found in dysembryoplastic neuroepithelial tumor, but does not display multinodularity. It usually manifests with symptoms related to increased intracranial pressure. Epilepsy has been reported in approximately one third of patients. PDGFRA gene mutations have been identified in the majority of patients. Alterations in FGFR1 and NF1 genes have also been reported. BRAF mutations which represent the most common molecular alteration found in cortical dysembryoplastic neuroepithelial tumor, were absent in this rare group of midline tumors.


Childhood Parathyroid Gland Adenoma

An adenoma of the parathyroid gland that occurs during childhood.


Parathyroid Gland Lipoadenoma

A parathyroid gland adenoma that contains mature adipocytes.


Stage IV Childhood Retinoblastoma by Toronto Guidelines v2

Distant metastatic disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 2 Gingiva Intra-Operative Injury, CTCAE


Grade 4 Treatment Related Secondary Malignancy, CTCAE

Acute life-threatening secondary malignancy; blast crisis in leukemia


Thyroid Gland Cavernous Hemangioma

A rare cavernous hemangioma that arises from the thyroid gland.


Benign Thyroid Gland Vascular Neoplasm

A rare benign vascular neoplasm that arises from the thyroid gland. This category includes hemangiomas, cavernous hemangiomas, and lymphangiomas.


Thyroid Gland Hemangioma

A rare hemangioma that arises from the thyroid gland.


Thyroid Gland Lymphangioma

An extremely rare lymphangioma that arises from the thyroid gland.


Grade 5 Vasovagal Reaction, CTCAE

Death


Stage IIIB Cervical Cancer AJCC v8

Stage IIIB includes: T3b, Any N, M0. T3b: extending to pelvic wall and/or causing hydronephrosis or nonfunctioning kidney. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 5 Lung Infection, CTCAE

Death


Peritoneal mesothelioma malignant recurrent

The reemergence of malignant peritoneal mesothelioma after a period of remission.


Mesothelioma malignant recurrent

The reemergence of malignant mesothelioma after a period of remission


Grade 5 Edema Cerebral, CTCAE

Death


Grade 3 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Thoracic Esophagus Adenocarcinoma

An adenocarcinoma that arises from the thoracic esophagus.


Grade 5 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Fundic gland polyp

The most common gastric polyp in the Western hemisphere.  The lesion consists of a localized hyperplasia of the deep epithelial compartment of the oxyntic mucosa, with variable degrees of cystic dilatation.  Malignant transformation is the exception.  (WHO, 2000)


Grade 1 Pharynx Obstruction and Stenosis, CTCAE


Stage II Rectosigmoid Cancer AJCC v7

Stage II includes: IIA (T3, N0, M0); IIB (T4a, N0, M0); IIC (T4b, N0, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 2 Abducens Nerve Disorder, CTCAE

Moderate symptoms; limiting instrumental ADL


phenylalanine

An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.


Clinical Stage 0 Merkel Cell Carcinoma AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: In situ primary tumor. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Merkel Cell Carcinoma by AJCC v8 Clinical Stage

A term that refers to the clinical staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


Clinical Stage IV Merkel Cell Carcinoma AJCC v8

Stage IV includes: T0-4, Any N, M1. T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. M1: Distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Clinical Stage IIA Merkel Cell Carcinoma AJCC v8

Stage IIA includes: T2-3, N0, M0. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Clinical Stage IIB Merkel Cell Carcinoma AJCC v8

Stage IIB includes: T4, N0, M0. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Clinical Stage II Merkel Cell Carcinoma AJCC v8

Stage II includes: IIA: (T2-3, N0, M0); IIB: (T4, N0, M0). T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Clinical Stage III Merkel Cell Carcinoma AJCC v8

Stage III includes: T0-4, N1-3, M0. T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1: Metastasis in regional lymph node(s). N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Clinical Stage I Merkel Cell Carcinoma AJCC v8

Stage I includes: T1, N0, M0. T1: Maximum clinical tumor diameter equal to or less than 2 cm. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Small Intestinal Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small intestine. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Small Intestinal Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small intestine.  It is characterized by the presence of malignant large cells.


Recurrent Rectal Cancer

The reemergence of rectal carcinoma after a period of remission.


Rectal adenocarcinoma recurrent

The reemergence of rectal adenocarcinoma after a period of remission.


Adrenal Suppression

Inadequate production of cortisol due to negative feedback on the hypothalamic-pituitary-adrenal axis that is caused by exposure to exogenous glucocorticoids or endogenous hypercortisolism.


Radiating Chest Pain in Abdomen

The location of the radiating chest pain is in the abdomen.


Hemoglobin Increase Greater than or Equal to 1.5 g/dL

A semiquantitative finding indicating that the concentration of hemoglobin has increased by at least 1.5 g/dL compared to the value recorded for a previous sample from that subject.


polyatomic cation

A cation consisting of more than one atom.


phosphocholines

Any compound having phosphocholine as part of its structure.


phosphatidylcholine

A glycerophosphocholine that is glycero-3-phosphocholine bearing two acyl substituents at positions 1 and 2.


The conjugate base of a 1,2-diacyl-sn-glycero-3-phosphocholine compound formed by deprotonation of the phosphate OH group.


An ammonium ion that is the conjugate acid of pyridoxamine arising from selective protonation of the primary amino group; major species at pH 7.3.


(S)-bethanechol

The (S)-enantiomer of bethanechol.


A 1,2-diacyl-sn-glycero-3-phosphocholine where the acyl group at position 1 is unspecified while the acyl group at position 2 is palmitoyl.


glycerophosphocholine

The glycerol phosphate ester of a phosphocholine. A nutrient with many different roles in human health.


A phosphatidylcholine 36:3 in which the acyl groups specified at positions 1 and 2 are octadecanoyl and (6Z,9Z,12Z)-octadecatrienoyl respectively.


ammonium ion derivative

A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).


phosphatidylcholine 32:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 0 double bonds.


A primary ammonium ion that is the conjugate acid of thiamine(1+) resulting from the protonation of the primary amino group.


(R)-bethanechol

The (R)-enantiomer of bethanechol.


acylcholine

A choline ester formed from choline and a carboxylic acid.


cholines

A quaternary ammonium ion based on the choline ion and its substituted derivatives thereof.


quaternary ammonium ion

A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.


Lumbar Spine Joint Range of Motion Decreased

Decreased flexibility of a lumbar spine joint.


Stage IIIB Cervical Cancer FIGO 2018

Cervical carcinoma with extension to the pelvic wall and/or hydronephrosis or nonfunctioning kidney (unless known to be due to another cause). (FIGO 2018)


Grade 5 Pharynx Stricture or Stenosis, CTCAE


Grade 4 Pharynx Stricture or Stenosis, CTCAE


Grade 1 Pharynx Stricture or Stenosis, CTCAE


Grade 3 Pharynx Stricture or Stenosis, CTCAE


Grade 2 Pharynx Stricture or Stenosis, CTCAE


Leaflet Disruption Due To Calcification

The disturbance of a cusp of a heart valve secondary to the accumulation of calcium on the valve tissue. This most often results in stenosis of the valve.


Leaflet Disruption

The disturbance of a cusp of a heart valve, often resutling in dysfunction of the valve.


Leaflet Disruption Due To Infection

The disturbance of a cusp of a heart valve secondary to infection affecting the valve tissue, which can result in valvular dysfunction.


Leaflet Disruption Due To Unknown Cause

The disturbance of a cusp of a heart valve without an identifiable cause.


Leaflet Disruption Due To Host Tissue Overgrowth

The disturbance of a cusp of a heart valve secondary to an increase in tissue mass at the valve site, which can lead to valve dysfunction. This often happens as a result of fibrosis of tissue surrounding the suture line of a prosthetic valve.


Leaflet Disruption Due To Suture Abrasion

The disturbance of a cusp of a heart valve secondary to irritation by surgical sutures, which can result in valvular dysfunction.


Vulvar Fibroadenoma

A benign epithelial-stromal neoplasm that arises from the vulva and resembles the breast fibroadenoma.


Fibroadenoma of Anogenital Mammary-Type Glands

A benign epithelial-stromal neoplasm that arises from the perineum and resembles the breast fibroadenoma.


Anal Fibroadenoma

A benign epithelial-stromal neoplasm that arises from the anus and resembles the breast fibroadenoma.


Esophageal Squamous Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities involve either the lower or both the lower and the upper half of the esophageal squamous epithelium.


High Grade Esophageal Squamous Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal squamous epithelium.


Low Grade Esophageal Squamous Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal squamous epithelium.


Extramedullary Disease in Plasma Cell Myeloma Involving the Liver

Infiltration of the hepatic sinusoids by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Grade 4 Cecal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Urostomy Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Grade 3 Lipohypertrophy, CTCAE

Covering >30% BSA and associated tenderness and narcotics or NSAIDs indicated; lipohypertrophy; limiting self care ADL


Percentage Body Weight Gain

The amount of weight gained over a period of time in relation to the total weight.


A secondary amino compound that is ammonia in which nitrogen is substituted by a 1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl group and a 2-(2-ethoxyphenoxy)ethyl group.


Stage IIIA Gastric Gastrointestinal Stromal Tumor

Stage IIIA includes: T3, N0, M0, Mitotic rate: High. T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


sulfate

A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.


Long-Term Effects Secondary to Cancer Therapy in Adults

Side effects of cancer treatment received during adulthood occurring a long time after the treatment was completed.


Hemangioendothelioma, benign

A benign vascular proliferation characterized by the presence of prominent endothelial cells and the formation of vascular channels.


Grade 3 Mania, CTCAE

Severe manic symptoms (e.g., hypomania; major sexual or financial indiscretions); hospitalization not indicated; new onset


Mania, CTCAE

A disorder characterized by excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood.


Grade 4 Mania, CTCAE

Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Grade 2 Mania, CTCAE

Moderate manic symptoms (e.g., relationship and work difficulties; poor hygiene)


Grade 1 Mania, CTCAE

Mild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep)


Grade 5 Mania, CTCAE

Death


Stage IIIA Rectal Neuroendocrine Tumor AJCC v8

Stage IIIA includes: T4, N0, M0. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colorectal Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a colorectal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to colorectal "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the colon and rectum are not staged using this staging system. (from AJCC 8th Ed.)


Stage I Colorectal Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIB Colon Neuroendocrine Tumor AJCC v8

Stage IIB includes: T3, N0, M0. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIB Rectal Neuroendocrine Tumor AJCC v8


Stage IIIB Colon Neuroendocrine Tumor AJCC v8

Stage IIIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIB Rectal Neuroendocrine Tumor AJCC v8


Rectal Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a rectal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to rectal "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the rectum are not staged using this staging system. (from AJCC 8th Ed.)


Stage IIB Colorectal Neuroendocrine Tumor AJCC v8


Stage IIA Colorectal Neuroendocrine Tumor AJCC v8

Stage IIA includes: T2, N0, M0. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIA Rectal Neuroendocrine Tumor AJCC v8


Colon Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a colon neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to colon "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the colon are not staged using this staging system. (from AJCC 8th Ed.)


Stage IIIB Colorectal Neuroendocrine Tumor AJCC v8


Stage I Colon Neuroendocrine Tumor AJCC v8


Stage IIIA Colon Neuroendocrine Tumor AJCC v8


Stage IIA Colon Neuroendocrine Tumor AJCC v8


Stage IIIA Colorectal Neuroendocrine Tumor AJCC v8


Grade 1 Cardiac Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Cardiac Disorders - Other, Specify, CTCAE


Grade 2 Cardiac Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 5 Cardiac Disorders - Other, Specify, CTCAE

Death


Grade 3 Cardiac Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 4 Cardiac Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Phosphaturic mesenchymal tumor, malignant

A phosphaturic mesenchymal tumor characterized by the presence of nuclear atypia, high mitotic activity, increased cellularity, marked pleomorphism, and necrosis. It usually develops in lesions that have recurred locally and metastasizes to other sites.


Metastatic malignant neoplasm to trachea

A malignant neoplasm that has spread to the trachea from another anatomic site.


Grade 1 Ejaculation Disorder, CTCAE

Diminished ejaculation


Ejaculation Disorder, CTCAE

A disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation.


Grade 2 Ejaculation Disorder, CTCAE

Anejaculation or retrograde ejaculation


Grade 4 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Bilateral Synchronous Sporadic Renal Cell Carcinoma

Non-hereditary renal cell carcinoma arising from a kidney and detected in the other kidney within six months of the first primary. The majority are clear cell renal cell carcinomas.


Kidney Germ Cell Tumor

A rare benign or malignant germ cell tumor that arises from the kidney.


Grade 3 Sinus Pain, CTCAE

Severe pain; limiting self care ADL


paraben

A 4-hydroxybenzoate ester in which the esterifying alcohol is an alkanol (in diagram, R = alkyl). Commonly used as preservatives in cosmetic and pharmaceutical products.


Arteriovenous graft thrombosis

Partial or complete occlusion of the lumen of an arteriovenous graft by a thrombus.


Grade 5 Epistaxis, CTCAE

Death


Grade 3 Trismus, CTCAE

Decreased ROM with inability to adequately aliment or hydrate orally


Refractory Childhood Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia that occurs in childhood and does not respond to treatment.


Childhood Acute Basophilic Leukemia

An acute basophilic leukemia occurring in children.


Sinonasal Solitary Fibrous Tumor

A solitary fibrous tumor that arises from the nasal cavity and paranasal sinuses.


Supernumerary Hemivertebra

More than the usual or expected number of hemivertebra.


Malignant neoplasm of hypopharynx recurrent

The reemergence of a hypopharyngeal malignant neoplasm after a period of remission.


Benign neoplasm of pyriform sinus

A neoplasm that arises from the pyriform sinus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Neoplasm of pyriform sinus

A benign or malignant neoplasm that affects the pyriform sinus.


COVID-19-Associated Anosmia

Anosmia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Grade 3 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Tentorial tear due to birth trauma

Pertaining to tears involving the tentorium of the cerebellum.


Grade 4 Stoma Pulmonary Hemorrhage, CTCAE


Resectable Carcinoma

Carcinoma that is amenable to surgical resection.


Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that is amenable to surgical resection.


Resectable Gallbladder Adenocarcinoma

Gallbladder adenocarcinoma that is amenable to surgical resection.


Carcinoma duodenum resectable

Carcinoma of the duodenum amendable to surgical removal.


Resectable Periampullary Adenocarcinoma

Periampullary adenocarcinoma that is amenable to surgical removal.


Resectable Liver and Intrahepatic Bile Duct Carcinoma

Liver and intrahepatic bile duct carcinoma that is amenable to surgical resection.


Resectable Merkel Cell Carcinoma

Merkel cell carcinoma that is amenable to surgical resection.


Resectable Digestive System Carcinoma

Digestive system carcinoma that is amenable to surgical resection.


Resectable Skin Squamous Cell Carcinoma

Skin squamous cell carcinoma that is amenable to surgical resection.


Localized Resectable Adult Liver Carcinoma

A localized hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and it is amenable to surgical resection.


Resectable Head and Neck Squamous Cell Carcinoma

Squamous cell carcinoma of the head and neck which is amendable to surgical removal.


Resectable Ampulla of Vater Adenocarcinoma

Ampulla of Vater adenocarcinoma that is amenable to surgical resection.


Resectable Appendix Carcinoma

Appendix carcinoma that is amenable to surgical resection.


Resectable Gastric Adenocarcinoma

Gastric adenocarcinoma that is amenable to surgical resection.


Resectable Skin Carcinoma

Skin carcinoma that is amenable to surgical resection.


Small intestine carcinoma resectable

Carcinoma of the small intestine amendable to resection.


Resectable Colon Carcinoma

Colon carcinoma that is amenable to surgical resection.


Localized Resectable Adult Hepatocellular Carcinoma

A localized hepatocellular carcinoma that occurs during adulthood and it is amenable to surgical resection.


Resectable Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction adenocarcinoma that is amenable to surgical resection.


Resectable Colorectal Carcinoma

Colorectal carcinoma that is amenable to surgical resection.


Carcinoma liver resectable

A hepatocellular carcinoma that is amenable to surgical resection.


Resectable Esophageal Adenocarcinoma

Esophageal adenocarcinoma that is amenable to surgical resection.


Resectable Bladder Urothelial Carcinoma

Bladder urothelial carcinoma that is amenable to surgical resection.


Grade 1 Scalp Pain, CTCAE

Mild pain


Childhood Cerebellar Anaplastic Astrocytoma

A cerebellar anaplastic astrocytoma that occurs during childhood.


Recurrent Childhood Cerebellar Astrocytoma

Regrowth of benign and malignant childhood cerebellar astrocytomas that have previously been subjected to surgical resection and less frequently other forms of therapy such as radiation or chemotherapy.  Recurrence of benign tumors (e.g., (pilocytic astrocytoma) may respond to a second surgical procedure.


Grade 2 Oral Cavity Pulmonary Fistula, CTCAE


Stage II Lip Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Lower Gingival Verrucous Carcinoma

A verrucous carcinoma of the oral cavity that arises from the lower gingiva.


Verrucous carcinoma of the oral cavity recurrent

Reemergence of verrucous carcinoma of the oral cavity after a period of remission.


Buccal Mucosa Verrucous Carcinoma

A verrucous carcinoma of the oral cavity that arises from the buccal mucosa.


Oral Cavity Carcinoma Cuniculatum

A variant of well-differentiated squamous cell carcinoma arising from the oral cavity. It is characterized by the presence of minimal cytological atypia, multiple keratin-filled crypts, and intraepithelial neutrophils.


Upper Gingival Verrucous Carcinoma

A verrucous carcinoma of the oral cavity that arises from the upper gingiva.


Positive Laboratory Test Result

A laboratory test result that indicates that a specific disease, condition, or attribute being assessed is present.


Human Immunodeficiency Virus 1 Positive

Indicates that human immunodeficiency virus 1 has been detected in a sample.


Progesterone Receptor Positive by Immunohistochemistry

An immunohistochemical staining finding indicating that cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 1-9 Percent

An immunohistochemical staining finding indicating that between 1 and 9 percent of the cells in a tissue sample are expressing progesterone receptor.


Disseminated Tumor Cells Positive

An indication that single tumor cells or small clusters of tumor cells have been detected in a tissue sample.


Progesterone Receptor Positive by Immunohistochemistry 81-90 Percent

An immunohistochemical staining finding indicating that 81-90 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Status 3+

An immunohistochemical result of 3 for progesterone receptor expression that is considered positive for expression.


Monoclonal Band

Monoclonal immunoglobulin or monoclonal light chain that is present in the serum and/or urine. It is the result of a clonal B-cell or plasma cell proliferation.


Hormone Receptor Positive

A finding indicating that the neoplastic cells in a tissue sample test positive for hormone receptors.


Progesterone Receptor Positive by Immunohistochemistry 51-60 Percent

An immunohistochemical staining finding indicating that 51-60 percent of the cells in a tissue sample are expressing progesterone receptor.


Expression Positive

An indication that the expression of a gene, transcript or protein has been detected in a sample.


Progesterone Receptor Positive by Immunohistochemistry Less than 20 Percent

An immunohistochemical staining finding indicating that less than 20 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry Less than 1 Percent

An immunohistochemical staining finding indicating that less than 1 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 91-100 Percent

An immunohistochemical staining finding indicating that 91-100 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 21-30 Percent

An immunohistochemical staining finding indicating that 21-30 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 71-80 Percent

An immunohistochemical staining finding indicating that 71-80 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 41-50 Percent

An immunohistochemical staining finding indicating that 41-50 percent of the cells in a tissue sample are expressing progesterone receptor.


Rearrangement Detected

An indication that a cytogenetic rearrangement was detected in a sample.


Progesterone Receptor Positive by Immunohistochemistry 31-40 Percent

An immunohistochemical staining finding indicating that 31-40 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 61-70 Percent

An immunohistochemical staining finding indicating that 61-70 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 1-10 Percent

An immunohistochemical staining finding indicating that 1-10 percent of the cells in a tissue sample are expressing progesterone receptor.