Inflamed Juvenile Conjunctival Nevus

A compound nevus that arises from the conjunctiva in children and adolescents. It is characterized by the presence of chronic inflammatory features.


Unresectable Myxoid Liposarcoma

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A myxoid liposarcoma that is not amenable to surgical resection.


Grade 1 Amylase, CTCAE

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Cheilitis, CTCAE

A disorder characterized by inflammation of the lip.


Grade 4 Hyperthyroidism, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Edema of the Trunk and Genital Area, CTCAE


Grade 3 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Fallopian Tube Hemorrhage, CTCAE


Disseminated Intravascular Coagulation Related to COVID-19

Disseminated intravascular coagulation in a patient with probable or confirmed acute COVID-19.


Grade 4 Neonatal Culture Negative Sepsis, AE

A culture negative neonatal sepsis adverse event in a newborn characterized by life-threatening consequences (e.g. shock, disseminated intravascular coagulation (DIC)); urgent major care change required.


Grade 5 Pneumonitis and Pulmonary Infiltrates, CTCAE


Upper Aerodigestive Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Grade 2 Gamma-Glutamyl Transpeptidase, CTCAE


Stage III Adult Diffuse Mixed Cell Lymphoma

Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Grade 4 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Appendix Carcinoma by AJCC v8 Stage

A term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas of the appendix, including high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and goblet cell carcinoids. Well-differentiated neuroendocrine tumors (carcinoids) are staged according to the classification for neuroendocrine tumors of the appendix. (from AJCC 8th Ed.)


Grade 3 Capillary Leak Syndrome, CTCAE

Severe symptoms; intervention indicated


Stage IA Vulvar Carcinoma AJCC v6

Stage IA includes: Tia, N0, M0.  T1a: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion no greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Assault by firearms

A physical attack with a gun.


Adenocarcinoma of the prostate stage II

Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Long-Term Effects Secondary to Cancer Therapy

Side effects of cancer treatment occurring a long time after the treatment was completed.


Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

A disorder characterized by headaches, mental status changes, visual disturbances, and/or seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition. Also known as posterior reversible encephalopathy syndrome (PRES).


Advanced Malignant Digestive System Neoplasm

A malignant digestive system neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Intraoperative Breast Injury, CTCAE

Partial resection of injured organ/structure indicated


Grade 1 Pneumothorax, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Localized Gastric Adenocarcinoma

An adenocarcinoma that arises from the stomach and has not spread to other anatomic sites.


Subjective Fever

A symptom report of fever without an objective temperature measurement.


FIGO Stage III Gestational Trophoblastic Tumor

Lesion affects the lungs, with or without known genital structures invasion.


Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive

A chronic myeloid leukemia, BCR-ABL1 positive occurring during childhood.


Grade 1 Myasthenia Gravis, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Chemically Induced Cardiotoxicity

Damage or injury to the heart caused by a chemical agent.


Mucosal nodular melanoma

Nodular melanoma that arises from a mucosal site.


Stage IIB Cervical Cancer FIGO 2009

Cervical carcinoma with parametrial invasion. (FIGO 2009)


Stage IVB Gestational Trophoblastic Tumor AJCC v7

Stage IVB includes: Any T, M1b, Risk factors: high risk.  M1b: All other distant metastasis.  (AJCC 7th ed.)


Chest Pain Along Anterior Axillary Line

The location of the chest pain is along an imaginary vertical line that descends along the lateral aspect of the chest wall originating from the armpit.


ALK-Positive Histiocytosis

A rare histiocytic neoplasm associated with ALK gene rearrangement leading to activation of signaling pathways. The neoplastic cells have a mature histiocytic phenotype, and usually have a foamy cytoplasm. It is characterized by frequent neurologic involvement and responds to ALK inhibition treatments.


Astler-Coller B3 Colon Carcinoma

Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


FIGO Stage IIA Gestational Trophoblastic Tumor


Grade 1 Mucositis Oral, CTCAE

Asymptomatic or mild symptoms; intervention not indicated


Rectal Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the rectal region.


Grade 2 Rhinitis Infective, CTCAE

Localized; local intervention indicated


Liquid Tumor

A malignant tumor that originates from myeloid or lymphoid cells i.e., leukemias and lymphomas.


Benign fibrohistiocytic neoplasm

A mesenchymal neoplasm composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes, in a storiform pattern. There is no evidence of atypical or malignant cytological and architectural features, invasive features, or metastases.


Bone Malignant Peripheral Nerve Sheath Tumor

An exceedingly rare malignant peripheral nerve sheath tumor that arises from the bone.


Lung Adenocarcinoma with Mixed Bronchioloalveolar and Invasive Components

A lung adenocarcinoma consisting of a bronchioloalveolar component and an invasive adenocarcinomatous component.


Grade 4 Pneumothorax, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Rectum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Multi-Organ Failure, CTCAE

A disorder characterized by progressive deterioration of the lungs, liver, kidney and clotting mechanisms.


Stage II Bone Cancer AJCC v7

Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 5 Somnolence and Depressed Level of Consciousness, CTCAE


Sarcoma of pelvis

Sarcoma involving the organs and structures of the pelvis.


Refractory Anaplastic Astrocytoma

An anaplastic astrocytoma that is resistant to treatment.


Old Burn Scar-Related Skin Squamous Cell Carcinoma

A squamous cell carcinoma of the skin that arises from burn scars. It usually manifests between 20 and 40 years after the original burn.


Grade 1 Weight Loss, CTCAE

5 to <10% from baseline; intervention not indicated


Grade 5 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Cartilage Intra-Operative Injury, CTCAE


Grade 3 Colonic Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 2 Penile Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Upper Aerodigestive Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Cervical Invasive Stratified Mucinous Adenocarcinoma

A rare, distinct form of invasive cervical mucinous adenocarcinoma associated with human papillomavirus infection. It is characterized by the presence of stratiﬁed, immature epithelial cells containing varying quantities of intracytoplasmic mucin.


Ileal Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the ileum.


Grade 1 Hemolysis, CTCAE

Laboratory evidence of hemolysis only (e.g., direct antiglobulin test; DAT; Coombs'; schistocytes; decreased haptoglobin)


Stage IVB Appendix Carcinoma AJCC v7

Stage IVB includes: (Any T, N0, M1a, G2, G3); (Any T, N1, M1a, Any G); (Any T, N2, M1a, Any G).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N2: Metastasis in four or more regional lymph nodes.  M1a: Intraperitoneal metastasis beyond the right lower quadrant, including pseudomyxoma peritonei.  G2: Moderately differentiated tumor. G3: Poorly differentiated tumor.  (AJCC 7th ed.)


Neoplasm of uncertain behavior

A neoplasm displaying morphologic, phenotypic, or genotypic characteristics that are clearly not benign but do not permit the establishment of a definitive diagnosis of malignancy.  Such neoplasms may or may not eventually have a more aggressive clinical course.  Representative examples include lymphoproliferations of uncertain malignant potential (e.g., lymphomatoid granulomatosis and lymphomatoid papulosis), borderline ovarian epithelial neoplasms (e.g., borderline ovarian endometrioid tumor and borderline ovarian mucinous tumor), borderline exocrine pancreatic neoplasm (e.g., pancreatic borderline intraductal papillary-mucinous neoplasm), and primary borderline peritoneal epithelial neoplasm.


Grade 2 Fatigue, CTCAE

Fatigue not relieved by rest; limiting instrumental ADL


Hernia, Diaphragmatic, Traumatic

The protrusion of abdominal cavity contents into the thoracic cavity via a hole in the diaphragm, which was acquired via a traumatic etiology.


Peritoneal and retroperitoneal haemorrhages

Bleeding originating in and behind the tissues that line the wall of the abdominal cavity, intestine, and mesentery.


Grade 1 Vomiting, CTCAE

Intervention not indicated


Grade 2 Menorrhagia, CTCAE

Moderate symptoms; medical intervention indicated (e.g., hormones)


Grade 2 Neonatal Culture Positive Sepsis, AE

An adverse event in a newborn characterized by a positive blood culture positive with mild or ambiguous signs; anti-infectives initiated.


Grade 5 Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Unresectable Urothelial Carcinoma

Urothelial carcinoma that is not amenable to surgical resection.


Adverse Event Associated with Dermatology and Skin


Grade 4 Neonatal Hypotension, AE

A hypotensive adverse event in a newborn characterized by life-threatening consequences (e.g. shock, organ failure).


Recurrent Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

The reemergence of undifferentiated high grade pleomorphic sarcoma of bone in adulthood after a period of remission.


Pyramidal Tract Syndrome, CTCAE

A disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination.


Metastatic Sarcoma in the Peritoneum

A sarcoma that has spread to the peritoneum from an adjacent or distal anatomic site.


Tumor Flare Reaction

A side effect of cancer treatment. It has been described in patients with chronic lymphocytic leukemia treated with lenalidomide, breast cancer patients during the initial phase of hormonal treatment, and in prostate cancer patients treated with luteinizing hormone-releasing hormone agonists. Symptoms include a sudden and painful increase in the tumor size, rash, low grade fever, bone pain, hypercalcemia, and an increase in the tumor markers levels.


Grade 5 Upper Extremity Artery Injury, CTCAE


Grade 3 Gait Disturbance, CTCAE

Limiting self care ADL


Grade 3 Cranial Nerve III Intra-Operative Injury, CTCAE


Refractory Pancreatobiliary Carcinoma

Pancreatobiliary carcinoma that is resistant to treatment.


Grade 2 Renal Calculi, CTCAE

Symptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated


Acquired phimosis

Phimosis that develops in an uncircumcised male with a previously loose foreskin.


Platinum-Resistant Fallopian Tube Carcinoma

Fallopian tube carcinoma that progresses between one and six months of completing the last platinum therapy.


Recurrent Langerhans Cell Histiocytosis

The reemergence of Langerhans cell histiocytosis after a period of remission.


Grade 3 Ileum Stricture or Stenosis, CTCAE


Undifferentiated schizophrenia

A subtype of schizophrenia in which the individual exhibits the characteristic symptoms of schizophrenia but the overall picture is not one of catatonic type, paranoid type, or disorganized type schizophrenia.


Stent thrombosis

The formation of a blood clot of a vessel or heart chamber after and due to the placement of a stent.


Grade 1 Generalized Edema, CTCAE

Noted on exam; 1+ pitting edema


Foregut Cyst

A cyst originating from the primitive foregut.  It may arise from the upper aerodigestive tract, tracheobronchial tree, liver, and pancreas.


Stage IIB Nasopharyngeal Keratinizing Squamous Cell Carcinoma


Hairy Polyp

A benign polypoid lesion that usually arises from the nasopharynx. It may also occur in the oropharynx, palate, tonsil, tongue, lip, and middle ear. It usually affects neonates and older infants and is composed of ectoderm and mesoderm.


Chronic Bacterial Prostatitis

A chronic infection of the prostate gland caused by bacteria.  It is manifested with recurring urinary tract infections.  The culture of the prostatic fluid, semen, or post-massage urine specimen reveals the presence of bacteria.


Abducens Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the abducens nerve (sixth cranial nerve).


Grade 4 Hypernatremia, CTCAE

>160 mmol/L; life-threatening consequences


Oculomotor Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the oculomotor nerve (third cranial nerve).


Stage I Cervical Cancer AJCC v9

Stage I includes: T1, N0, M0. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


MAC lymphadenitis

Lymph node infection by Mycobacterium avium or Mycobacterium intracellulare. It most often affects children and usually presents with cervical lymph node enlargement. It generally follows a benign clinical course.


Malignant fibrohistiocytic neoplasm

A fibrohistiocytic neoplasm that metastasizes to other anatomic sites.


Grade 5 Urinary Retention, CTCAE

Death


Oligometastatic Prostate Carcinoma

Prostate carcinoma that has metastasized to a limited number of sites.


Grade 2 Colonic Stenosis, CTCAE

Symptomatic; altered GI function


Grade 3 Ureter Intra-Operative Injury, CTCAE


Terrifying Pain

A sensation of discomfort or distress that is frightening or scary.


Grade 3 Prostate Stricture or Stenosis, CTCAE


Grade 5 Renal and Urinary Disorders - Other, Specify, CTCAE

Death


Grade 3 Esophageal Perforation, CTCAE

Invasive intervention indicated


Mixed Morphea

The presence of more than one variant of morphea in a single patient.


Stage III Vaginal Cancer AJCC v6 and v7

Stage III includes: (T1-3, N1, M0) and (T3, N0, M0). T1: Tumor confined to vagina.  T2: Tumor invades paravaginal tissues but not to pelvic wall.  T3: Tumor extends to pelvic wall.  N0: No regional lymph node metastasis.  N1: Pelvic or inguinal lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 5 Anal Fistula, CTCAE

Death


Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Airway Tumor Mass

A tumor mass that is located in the airways.


Grade 1 Scrotal Pain, CTCAE

Mild pain


FIGO Grade 1 Endometrioid Adenocarcinoma

Endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


Grade 2 Upper Aerodigestive Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


Psammocarcinoma

An extremely rare variant of serous carcinoma arising from the ovary or peritoneum. It is characterized by extensive formation of psammoma bodies, low-grade cytological features, and invasion of surrounding structures.


Grade 4 Atrial Fibrillation, CTCAE

Life-threatening consequences; embolus requiring urgent intervention


Refractory Adenoid Cystic Carcinoma

Adenoid cystic carcinoma that is resistant to treatment.


Recurrent Skin Carcinoma

A carcinoma of the skin that has recurred after a period of remission.


Locally Advanced Malignant Digestive System Neoplasm

A malignant digestive system neoplasm that has spread to nearby tissues or lymph nodes.


Stage III Esophageal Adenocarcinoma AJCC v7

Stage III includes: IIIA (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G); IIIB (T3, N2, M0, Any G); IIIC (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 1 Gallbladder Fistula, CTCAE

Asymptomatic


Grade 4 Parathyroid Intra-Operative Injury, CTCAE


High-Grade Biliary Intraepithelial Neoplasia

Biliary intraepithelial neoplasia characterized by the presence of high grade epithelial dysplasia.


Grade 4 Small Intestinal Mucositis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Delusions, CTCAE

Moderate delusional symptoms


Eyelid Function Disorder, CTCAE

A disorder characterized by impaired eyelid function.


autosomal dominant dyskeratosis congenita 1

Dyskeratosis congenita caused by autosomal dominant mutation(s) in the TERC gene, encoding telomerase RNA component.


Stage IVA Bone Sarcoma AJCC v7

Stage IVA includes: Any T, N0, M1a, Any G.  N0: No regional lymph node metastasis.  M1a: Distant metastasis to lung. (AJCC 7th ed.)


Grade 3 Rectal Mucositis, CTCAE

Severe symptoms; limiting self care ADL


Metastatic Neoplasm to the Gallbladder

A malignant neoplasm that has spread to the gallbladder from another anatomic site.  Representative examples include metastatic melanoma, and metastatic carcinomas from the breast and the stomach.


Appendix Low Grade Intraepithelial Neoplasia

A precancerous intraepithelial neoplastic lesion that affects the appendix.  It is characterized by the presence of mild dysplasia and mild architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


Grade 2 Stomal Ulcer, CTCAE

Symptomatic; medical intervention indicated


Suppurative Granuloma

A granuloma caused by infectious organisms and characterized by the presence of abscess formation.


Grade 1 Pelvis NOS Intra-Operative Injury, CTCAE


Neuroendocrine Carcinoma, Excluding Head and Neck

A high-grade carcinoma with neuroendocrine differentiation. This category includes small cell carcinomas, large cell neuroendocrine carcinomas, and Merkel cell carcinomas and excludes neuroendocrine carcinomas that arise from the head and neck. The head and neck neuroendocrine carcinomas include well-differentiated, moderately-differentiated, and poorly-differentiated (high-grade) neuroendocrine carcinomas.


Thrombosis of blood vessel

The formation of a blood clot in the lumen of a vessel; causes include coagulation disorders, and vascular endothelial injury.


Grade 3 Ileal Perforation, CTCAE

Invasive intervention indicated


Stoma Site Infection, CTCAE

A disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body).


CD4 Lymphocytes Decreased, CTCAE

A finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen.


Grade 3 Generalized Edema, CTCAE

Interferes with self care ADL; intravenous therapy indicated; skin breakdown


Trichoadenoma

A rare benign tumor of the hair follicle occurring usually in the face or buttocks.


Hepatitis B Reactivation, CTCAE

A disorder characterized by the reactivation of hepatitis B virus.


Pathologic Stage III Cutaneous Melanoma AJCC v8

Stage III includes: IIIA: (T1a/b-T2a, N1a or N2a, M0); IIIB: (T0, N1b, N1c, M0); (T1a/b-T2a, N1b/c or N2b, M0); (T2b/T3a, N1a-N2b, M0); IIIC: (T0, N2b, N2c, N3b or N3c); (T1a-T3a, N2c or N3a/b/c, M0); (T3b/T4a, Any N greater than or equal to N1, M0); (T4b, N1a-N2c, M0); IIID: (T4b, N3a/b/c, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N2c: One clinically occult nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 1 Testicular Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 3 Pancreas Intra-Operative Injury, CTCAE


Supraventricular Tachycardia, CTCAE

A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles.


Pancreatic Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the pancreas.


Stage I Anal Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor 2 cm or smaller. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Upper Airway Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Grade 3 Infusion Related Reaction, CTCAE

Prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae


A hepatocellular adenoma caused by inactivating mutations of the HNF1A gene.  It is characterized by the presence of lobulated contours, steatosis, and absence of inflammation or nuclear atypia.


Lower Extremity Soft Tissue Necrosis, CTCAE


Pharyngeal Hemorrhage, CTCAE

A disorder characterized by bleeding from the pharynx.


Chest Pain in Mid Sternum

The location of the chest pain is in the middle of the sternum.


Grade 4 Pleura Intra-Operative Injury, CTCAE


Grade 5 Gallbladder Obstruction, CTCAE

Death


Simple Endometrial Hyperplasia with Atypia

A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is present.


Grade 1 Paronychia, CTCAE

Nail fold edema or erythema; disruption of the cuticle


Stage II Cervical Cancer AJCC v7

Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0); IIB (T2b, N0, M0); T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 4 Rectal Mucositis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 1 Neck Edema, CTCAE

Asymptomatic localized neck edema


Childhood Malignant Central Nervous System Neoplasm

A primary or metastatic malignant neoplasm that affects the central nervous system and occurs during childhood.


Grade 3 Glossopharyngeal Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Juvenile systemic scleroderma

Systemic sclerosis that is diagnosed in children. Juvenile systemic sclerosis is more likely to be of the overlap variant and presents with musculoskeletal involvement.


Grade 5 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Spontaneous Perforation

A hole through the wall of an organ that occurs without external influence.


Grade 4 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cancer Fatigue

A debilitating tiredness or total lack of energy, often reported as the most common symptom in individuals with cancer.  Cancer fatigue can result from chemotherapy, radiation therapy, surgery, and other treatments; chemotherapy-induced anemia is a very frequent cause. -- 2004


Pancreatic Hemorrhage, CTCAE

A disorder characterized by bleeding from the pancreas.


Grade 4 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


Uterine Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures).


Grade 1 Sinus Pain, CTCAE

Mild pain


Precursor T-lymphoblastic lymphoma/leukemia stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, or nodular involvement of the lungs(s).


Clinical Stage III Retinoblastoma AJCC v8

Stage III includes: (cT4b, cN0, cM0, Any H); (Any cT, cN1, cM0, Any H). cT4b: Extraocular tumor clinically evident with proptosis and/or an orbital mass. cN0: No regional lymph node involvement. cN1: Evidence of preauricular, submandibular, and cervical lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Grade 3 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Grade 1 Phlebitis Infective, CTCAE

Localized, local intervention indicated


Stage II Testicular Cancer AJCC v8

Stage II includes: Any pT/TX, N1-3, M0, SX. TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Grade 4 Urostomy Site Bleeding, CTCAE

Life-threatening consequences; urgent intervention indicated


Congenital ankyloblepharon

A congenital abnormality in which the margins of the upper and lower eyelids are fused together by bands of tissue.


Grade 3 Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Spiradenocylindroma

A benign adnexal neoplasm with histological features of both spiradenoma and cylindroma in a single nodular lesion.


Grade 4 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Facial Pain, CTCAE

Mild pain


Midgut Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the jejunum, ileum, proximal colon, or appendix. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Grade 4 Ventricular Arrhythmia NOS, CTCAE


Thrombosis or Thrombus or Embolism, CTCAE


Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Cutaneous Fistula

An abnormal communication between the skin and another organ or cavity.


Grade 4 Duodenum Stricture or Stenosis, CTCAE


Grade 4 Jejunum Intra-Operative Injury, CTCAE


Metastatic Genitourinary System Carcinoma

A carcinoma that arises from the genitourinary system and has metastasized to other anatomic sites.


Unresectable Anal Squamous Cell Carcinoma

Anal squamous cell carcinoma that is not amenable to surgical resection.


Malignant cylindroma

A carcinoma that arises in a cylindroma.


Grade 2 Hepatitis Viral, CTCAE

Moderate symptoms; medical intervention indicated


Grade 5 Obstruction Gastric, CTCAE

Death


Grade 1 Supraventricular Tachycardia, CTCAE

Asymptomatic, intervention not indicated


Unresectable Pancreatic Neuroendocrine Neoplasm

A pancreatic neuroendocrine neoplasm that is not amenable to surgical resection.


Grade 2 Tracheal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Radiating Chest Pain Along Left Middle Sternal Border

The location of the radiating chest pain is along the left middle sternal border.


Non-Neoplastic Hair Disorder

A non-neoplastic disorder that affects the hair. Representative examples may include alopecia, male pattern baldness, hirsutism, and hair shaft disorders.


Increased NPN

A laboratory test result indicating abnormally high concentration of non-protein nitrogen in the blood.


Grade 5 Intraoperative Musculoskeletal Injury, CTCAE

Death


High Grade Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


Acute Myocardial Injury Related to Acute COVID-19

Acute myocardial injury in an individual with probable or confirmed COVID-19 infection and no alternative explanation for acute myocardial injury.


Grade 1 Small Intestinal Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Major Visceral Vein Intra-Operative Injury, CTCAE


Grade 4 Vein NOS Intra-Operative Injury, CTCAE


Lugano Classification Stage IE Adult Hodgkin Lymphoma AJCC v8

Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Grade 2 Nose Intra-Operative Injury, CTCAE


Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Iron Overload, CTCAE

Severe symptoms; intervention indicated


Grade 2 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent

Acute myeloid leukemias and myelodysplastic syndromes arising as a result of the mutagenic effect of alkylating agents that are used for the treatment of malignant tumors. Patients usually develop a myelodysplastic syndrome which may evolve to a higher grade myelodysplastic syndrome or acute myeloid leukemia. A minority of patients present with an acute myeloid leukemia. Clonal cytogenetic abnormalities are frequently present and usually are unbalanced translocations or deletions of chromosomes 5 and 7. Patients with acute myeloid leukemia usually do not respond to treatment and have an unfavorable clinical outcome.


Seminal Vesicle Squamous Cell Carcinoma

An extremely rare squamous cell carcinoma that arises from the seminal vesicle. Glandular formation and mucin secretion are absent.


Grade 4 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Gastrointestinal Leak NOS, CTCAE


Childhood Diffuse Astrocytoma, MYB-Altered

A rare diffuse astrocytoma, MYB-altered that occurs during childhood.


Respiratory, Thoracic and Mediastinal Disorders, CTCAE


Grade 2 Irregular Menstruation, CTCAE

Intermittent/irregular menses for more than 3 consecutive menstrual cycles


Intermediate Grade Lung Neuroendocrine Neoplasm

An intermediate grade malignant neoplasm with neuroendocrine differentiation that arises from the lung.  This category includes atypical carcinoid tumor.


Disorder of AMH Receptor

A defect in the Anti-Muellerian hormone receptor.


Childhood L2 Acute Lymphoblastic Leukemia

L2 acute lymphoblastic leukemia that occurs during childhood.


Grade 3 Cranial Nerve X Intra-Operative Injury, CTCAE


Grade 1 Vulval Infection, CTCAE

Localized, local intervention indicated


Grade 3 Cranial Nerve VII Neuropathy, CTCAE


Grade 2 Breast Function and Lactation, CTCAE


Mitochondrial Hydroxyacyl-Coenzyme A Dehydrogenase Hyperinsulinism

Hyperinsulinism due to inactivating mutation(s) in the gene HADH, encoding mitochondrial (short-chain) hydroxyacyl-coenzyme A dehydrogenase, resulting in loss of inhibition of glutamate dehydrogenase (GDH). This condition is also characterized by protein-induced hypoglycemia, but in contrast to GLUD1-associated hyperinsulinism, hyperammonemia is absent.


Grade 5 Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Human Papillomavirus-Related Cervical Squamous Cell Carcinoma

A cervical squamous cell carcinoma associated with human papillomavirus infection.


Circumferential Endothelial Hyperplasia

Intraluminal hyperplasia of endothelial cells, encircling the entire lumen.


Syncope, CTCAE 5.0

A disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain.


Grade 5 Central Nervous System Necrosis, CTCAE

Death


Grade 3 Wound Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 4 Neonatal Edema, AE

An edema adverse event in a newborn characterized by life threatening consequences (e.g. respiratory failure, shock); requiring urgent major care changes (e.g. intubation, dialysis).


Grade 4 Superior Vena Cava Vein Injury, CTCAE


Grade 2 Persistent Pulmonary Hypertension of the Newborn, AE

An adverse event in a newborn characterized by increased estimated right ventricular pressures; with moderate clinical symptoms; oxygenation index less than 25; minor care changes required.


Refractory Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma that is resistant to treatment.


Grade 4 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Arterial Thromboembolism, CTCAE

Life-threatening consequences; hemodynamic or neurologic instability; organ damage; loss of extremity(ies)


Grade 1 Neuroendocrine Gonadotropin Secretion Abnormality, CTCAE


Grade 4 Spinal Cord Compression, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Grade 5 Fallopian Tube Anastomotic Leak, CTCAE

Death


Grade 3 Pelvic Pain, CTCAE

Severe pain; limiting self care ADL


Stage I Uterine Corpus Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


acute systolic congestive heart failure

Acute congestive heart failure due to reduced contractility of the left ventricle.


Second degree uterine prolapse

The uterus has descended to the level of the hymen.


Grade 2 Hyperkalemia, CTCAE

>5.5-6.0 mmol/L; intervention initiated


Grade 3 Cranial Nerve VI Neuropathy, CTCAE


Grade 4 Other Metabolic and Laboratory, CTCAE


Grade 4 Hyperuricemia, CTCAE

Life-threatening consequences


High grade glandular intraepithelial neoplasia

A high grade intraepithelial neoplasia in which there is marked architectural distortion and crowding of the glands, associated with severe cellular atypia. The neoplastic cells display pleomorphic and hyperchromatic nuclei.


Grade 1 Heart Failure, CTCAE

Asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities


Pancreatic Enzymes Decreased, CTCAE

A finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen.


Malignant tumor of epidermal appendage

A malignant neoplasm that arises from the skin appendages.


Stage III Adult Diffuse Large Cell Lymphoma

Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Lipomatosis of Nerve

A tumor composed of mature adipocytes and fibrous tissue infiltrating the epineurium and peripheral nerves.  It is often seen at birth or during childhood and may be associated with macrodactyly.


Grade 2 Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Lower Extremity Intra-Operative Injury, CTCAE


Human Papillomavirus-Related Anal Squamous Cell Carcinoma

An anal squamous cell carcinoma related to infection with sexually transmittable human papillomavirus.


Grade 3 Retroperitoneal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Helicobacter Pylori-Related Carcinoma

A carcinoma that is caused by Helicobacter pylori.


Unresectable Neuroendocrine Tumor

A neuroendocrine tumor that is not amenable to surgical resection.


Local infection skin/subcut tissue NOS

An infection involving the surface of the skin and subcutaneous tissues in a defined area of the body.


Stage IIIB Uterine Corpus Cancer AJCC v7

Stage IIIB includes: T3b, N0, M0.  T3b: Tumor involves vagina (direct extension or metastasis) or parametrial tissue. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Grade 2 Pelvic Floor Muscle Weakness, CTCAE

Symptomatic, not interfering with bladder, bowel, or vaginal function; limiting instrumental ADL


Metastatic Non-Functioning Neuroendocrine Tumor

A non-functioning, well-differentiated neuroendocrine neoplasm that has spread from the original site of growth to another anatomic site.


Grade 2 Neonatal Respiratory Distress Syndrome, AE

An adverse event in a newborn characterized by clinical evidence of increased respiratory distress without significant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); corrected by minor adjustments in current ventilatory support, supplemental oxygen or non-invasive support.


Grade 1 Small Intestine Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


High Grade Prostatic Intraepithelial Neoplasia, Foamy Variant

High grade prostatic intraepithelial neoplasia characterized by the presence of large glands with papillary infoldings that contain cells with xanthomatous cytoplasm.


Urinary Incontinence, CTCAE 5.0

A disorder characterized by inability to control the flow of urine from the bladder.


Childhood Fibrous Histiocytoma

A fibrous histiocytoma that occurs during childhood.


Tooth Abrasion

Wearing away of tooth enamel by an outside mechanical force.


Monoclonal B-Cell Lymphocytosis, Non-Chronic Lymphocytic Leukemia Type

Monoclonal B-cell lymphocytosis characterized by the presence of fewer than 5 x 10^9/L abnormal B-lymphocytes in peripheral blood and absence of the characteristic immunophenotype of chronic lymphocytic leukemia. This type of monoclonal B-cell lymphocytosis does not progress to chronic lymphocytic leukemia.


Lacrimal Drainage System Carcinoma

A carcinoma that arises from the lacrimal sac, canaliculi, or nasolacrimal duct.


Chronic Intestinal Cryptosporidiosis

A chronic infection caused by Cryptosporidium parvum or hominis that manifests as enteritis. It usually occurs in immunocompromised patients including persons with AIDS, transplant recipients, patients receiving cytotoxic chemotherapy, and patients with hematologic malignancies.


Cortical Cataract Grade 2

A stage of cortical cataract characterized by 10-50% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Grade 3 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Automobile Accident

An accident occurring while aboard, or involving, an automobile.


Otitis External Ear Non Infectious, CTCAE


Grade 2 Biliary Tree NOS Intra-Operative Injury, CTCAE


Grade 3 Other Hemorrhage and Bleeding, CTCAE


Grade 3 Gastritis, CTCAE

Severely altered eating or gastric function; TPN or hospitalization indicated


Grade 1 Pancreatic Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 4 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Tumor Hemorrhage, CTCAE

Death


Grade 5 Upper Respiratory Infection, CTCAE

Death


Vaccine associated paralytic poliomyelitis

A rare, paralytic poliomyelitis associated with the orally administered live attenuated strain of the poliovirus, OPV.


Esophageal Adenocarcinoma by AJCC v8 Postneoadjuvant Therapy Stage

A term that refers to the postneoadjuvant therapy staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Diesel Exhaust Exposure

Environmental, occupational, or consumer-based exposure to volatiles and particulates present in diesel exhaust.


Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 2 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Urostomy Obstruction, CTCAE

A disorder characterized by blockage of the urostomy.


Stage III Cervical Cancer FIGO 2018

Cervical carcinoma that involves the lower third of the vagina and/or extends to the pelvic wall and/or causes hydronephrosis or nonfunctioning kidney and/or involves pelvic and/or para-aortic lymph nodes. (FIGO 2018)


Grade 4 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Malignant Digestive System Neoplasm

A malignant neoplasm that arises in the digestive system and has spread from its original site of growth to other anatomic sites.


Stage IV Pancreatic Cancer AJCC v6 and v7

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


Grade 2 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Fallopian Tube Mucinous Adenocarcinoma

The reemergence of fallopian tube mucinous adenocarcinoma after a period of remission.


Bladder Granular Cell Tumor

A rare granular cell tumor arising from the bladder. Most tumors are benign.


Epididymal Cystadenoma

A benign cystadenoma that arises from the epididymis.


Anal Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the anal canal.


Venous lake

A condition that is characterized by venous dilation, which presents as soft, compressible lesions.


Grade 1 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Central Nervous System Neoplasms, Primary

A benign or malignant neoplasm that arises from the brain or the spinal cord.


Serum Calcitonin Level Increased

A laboratory test result indicating an increased concentration of calcitonin in the blood serum.


Grade 4 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Moderate Adverse Event

An experience that is alleviated with simple therapeutic treatments. The event impacts usual daily activities. Includes laboratory test alterations indicating injury, but without long-term risk.


Cystic urethritis

A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by urothelial cells.


Peritoneal Infection, CTCAE

A disorder characterized by an infectious process involving the peritoneum.


Grade 1 Pulmonary Fibrosis Radiographic Changes, CTCAE


Substance Withdrawal Delirium

A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance withdrawal.


Grade 3 Infective Myositis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Venous Angioleiomyoma

A morphologic variant of angioleiomyoma characterized by the presence of thick-walled veins.


Grade 4 Hypoxic Ischemic Encephalopathy, AE

An adverse event in a newborn characterized by severe clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event with life-threatening consequences (e.g. respiratory depression, refractory seizures).


Malignant neoplasm musculoskeletal

A primary or metastatic malignant neoplasm that affects muscles and bones.


Sacral Plexus Intra-Operative Injury, CTCAE


Gingival odontogenic cyst

An odontogenic cyst found in the alveolar mucosa. (WHO 2017)


Grade 1 Kidney Intra-Operative Injury, CTCAE


Grade 4 Pancreatic Necrosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Childhood Benign Bone Neoplasm

A childhood neoplasm that arises from bone and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Direct Contact Transmission Infection

Infection produced by direct contact with another person.


Congenital hydroureter

Dilatation of the ureter caused by obstruction of urine flow that is present at birth.


Vulval Infection

An infectious process affecting the vulva. Causative agents include human papillomavirus, herpes virus, Trichomonas, and Candida. Symptoms include itching and pain in the genital area and discharge.


Adult Lymphocyte-Rich Classical Hodgkin Lymphoma

Lymphocyte-rich classic Hodgkin lymphoma that occurs in adults.


Grade 4 Bladder Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Mediastinum Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Forced Expiratory Volume Decreased, CTCAE


Conjunctival Compound Nevus

A compound nevus that arises from the conjunctiva. It usually occurs in the bulbar conjunctiva, caruncle, and plica semilunaris. It is characterized by the presence of nevus cells within the epithelium and in the substantia propria. Type A nevus cells are present in the junctional nests and superficial substantia propria, and type B nevus cells are present in the deeper layers of the subepithelial compartment.


Grade 3 Hyperlipidemia, CTCAE

Hospitalization; pancreatitis


Grade 5 Ascites, CTCAE

Death


Grade 2 Nasopharynx Intra-Operative Injury, CTCAE


Troublesome Pain

A sensation of discomfort or distress that worries an individual or interrupts their ability to complete desired activities.


Childhood Acute Myelomonocytic Leukemia

An acute myelomonocytic leukemia occurring in children.


Telangiectasia, CTCAE 5.0

A disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes.


Pneumococcal arthritis and polyarthritis


Third degree perineal laceration

Injury to perineum involving anal sphincter complex. (adapted from reVITALize)


Aggressive osteoblastoma

An osteoblastoma characterized by the presence of prominent epithelioid osteoblasts and recurrences.


Upper Airway NOS Intra-Operative Injury, CTCAE


Grade 2 Device Related Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal)


Advanced Digestive System Neuroendocrine Neoplasm

A digestive system neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Childhood Benign Neoplasm

A neoplasm that occurs during childhood and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Jejunal Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the intestinal contents in the jejunum.


Refractory Malignant Brain Neoplasm

A malignant brain neoplasm that is resistant to treatment.


Grade 1 Seroma, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IB Bone Sarcoma AJCC v7

Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Laryngopharyngeal Dysesthesia, CTCAE

A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx.


Invasive Ureter Urothelial Carcinoma with Glandular Differentiation

An invasive urothelial carcinoma of the ureter that exhibits glandular differentiation.


Grade 1 Spermatic Cord Perforation, CTCAE


Grade 3 Perforation Bile Duct, CTCAE

Invasive intervention indicated


Infant Acute Lymphoblastic Leukemia with MLL Rearrangement

An acute lymphoblastic leukemia with rearrangement of the KMT2A gene that occurs in infancy.


Multicystic mesothelioma, benign

A mesothelial neoplasm that arises from the peritoneum and rarely the pleura. It is characterized by the presence of multiple cysts lined by flattened or cuboidal mesothelial cells. There is no evidence of significant cytologic atypia or increased mitotic activity. It may reoccur. Rare cases of transformation to malignant mesothelioma have been reported.


Myeloid Neoplasms with Germline ETV6 Mutation

Autosomal dominant familial thrombocytopenia associated with germline ETV6 mutation and hematologic malignancies. The hematologic malignancies reported are diverse, including myelodysplastic syndrome, acute myeloid leukemia, chronic myelomonocytic leukemia, B lymphoblastic leukemia, and plasma cell myeloma. Non-hematological neoplasms, including colorectal adenocarcinoma, have been also reported in affected families. (WHO 2017)


supravesical fissure of urinary bladder

A urogenital anomaly characterized by infraumbilical exstrophy of a bladder open only in its upper portion and pubic diastasis.  It has been described in both males and females and may be associated with trisomy 18, omphalocele, and urethral duplication.


Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pulmonary Vein Intra-Operative Injury, CTCAE


Grade 1 Cranial Nerve XII Neuropathy, CTCAE


Vaginal Discharge, CTCAE

A disorder characterized by vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years.


Thrombosis or Embolism Vascular Access Related, CTCAE


Lymphangitis carcinomatosa

Extensive infiltration of the lymphatic vessels by cancer cells, resulting in widespread cancer dissemination.  The lymphatic vessels appear as palpable, cord-like structures, especially in skin areas overlying the carcinoma.


Grade 5 Small Intestine Ulcer, CTCAE

Death


Grade 3 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Postneoadjuvant Therapy Stage I Esophageal Adenocarcinoma AJCC v8

Stage I includes: T0-2, N0, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Lower Extremity Artery Intra-Operative Injury, CTCAE


Intratubular large cell hyalinizing Sertoli cell neoplasia

A clinically benign intratubular neoplastic proliferation of large Sertoli cells in the testis. It is associated with prominent basement membrane deposits. It occurs almost exclusively in patients with Peutz-Jeghers syndrome.


Grade 5 Urinary Tract Obstruction, CTCAE

Death


Grade 2 Hematuria, CTCAE

Symptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL


Voiding Disorders

A group of conditions comprising dysfunction of the storage and elimination of urine.


Grade 4 Mediastinum Intra-Operative Injury, CTCAE


Alcohol Intolerance, CTCAE

A disorder characterized by an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches.


Grade 1 Duodenal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Spongioneuroblastoma

A neuroectodermal tumor composed of neoplastic neural elements.


Grade 4 Restrictive Cardiomyopathy, CTCAE

Refractory heart failure or other poorly controlled cardiac symptoms


Grade 2 Eyelid Function Disorder, CTCAE

Symptomatic; nonoperative intervention indicated; limiting instrumental ADL


Cyst of hydatid of Morgagni

A cystic structure located between the ovary and fallopian tube.


Stage IV Gestational Trophoblastic Tumor AJCC v7

Stage IV includes: (Any T, M1b, Risk factors: unknown); IVA (Any T, M1b, Risk factors: low risk); IVB (Any T, M1b, Risk factors: high risk).  M1b: All other distant metastasis.  (AJCC 7th ed.)


Inferior Vena Cava Intra-Operative Injury, CTCAE


Pathologic Stage IA Esophageal Adenocarcinoma AJCC v8

Stage IA includes: (T1a, N0, M0, G1); (T1a, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. (AJCC 8th ed.)


Grade 2 Pancreatic Endocrine Glucose Intolerance, CTCAE


Grade 2 Urinary Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 1 Herpes Simplex Reactivation, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Post-biopsy Pain

A sensation of discomfort secondary to sampling of tissue or bodily fluid.


Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Childhood Giant Cell Tumor of Bone

A giant cell tumor of bone that occurs during childhood.


Differentiated vulvar intraepithelial neoplasia

HPV-negative vulvar squamous intraepithelial proliferation characterized by atypia of the basal and parabasal keratinocytes in an otherwise well-differentiated epithelium. Despite its subtle appearance, it has a high risk of malignant transformation. (WHO 2020)


Stage II Contiguous Adult Diffuse Large Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 2 Peritoneal Cavity Hemorrhage, CTCAE


Gallbladder Hyperplastic Polyp

A polypoid tumor that arises from the gallbladder.  It is characterized by the presence of elongated, serrated crypts lined by proliferative epithelium.


Grade 1 Intraoperative Neurological Injury, CTCAE

Primary repair of injured organ/structure indicated


Hernia of unspecified site without mention of obstruction or gangrene

The protrusion of an organ, or the fascia of an organ, through the wall of the cavity that normally contains it, without mention of obstruction or necrosis of the herniated contents.


Stage IB2 Cervical Cancer FIGO 2018

Invasive cervical carcinoma equal or more than 2 cm and less than 4 cm in greatest dimension. (FIGO 2018)


Combined Nevus

A nevus that contains two or more melanocytic nevus components in the same lesion. The cellular components can be any combination of any nevus variants, but most frequently, a common nevus component is combined with a blue nevus, deep penetrating nevus, or Spitz nevus component. (WHO 2018)


Grade 2 Larynx Obstruction and Stenosis, CTCAE


Luminal A Prostate Carcinoma

Prostate carcinoma associated with increased androgen receptor expression and signaling (androgen activity pathway), increased luminal markers, and a lower proliferation score than the luminal B and basal-like prostate carcinomas.


Pancreatic Medullary Carcinoma

A pancreatic ductal adenocarcinoma characterized by poor differentiation and a prominent syncytial growth pattern.  The prognosis is more favorable compared to conventional pancreatic ductal adenocarcinoma.


Sudden Death Not Associated with More Specific CTCAE Term, CTCAE


Refractory Urethral Urothelial Carcinoma

Urethral urothelial carcinoma that is resistant to treatment.


Acute perforated appendicitis

Acute appendicitis with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.


Childhood Hematopoietic and Lymphoid Cell Neoplasm

A myeloid or lymphoid cell neoplasm that occurs during childhood. Representative examples include acute leukemias and lymphomas.


Weight Gain, CTCAE

A finding characterized by an unexpected or abnormal increase in overall body weight; for pediatrics, greater than the baseline growth curve.


Grade 4 Esophageal Ulcer, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Urostomy Obstruction, CTCAE

Death


Refractory Acute Graft Versus Host Disease

Acute graft versus host disease that is resistant to treatment.


Grade 4 Constipation, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Injury of upper respiratory tract

Mechanical or chemical injuries to the upper airways, including trachea, pharynx and larynx.


Childhood Anaplastic Oligodendroglioma

An anaplastic oligodendroglioma that arises from the central nervous system and occurs during childhood.


Refractory Uterine Corpus Cancer

Uterine corpus cancer that is resistant to treatment.


Grade 3 Anal Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated


Grade 3 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IVA Cervical Cancer FIGO 2018

The cervical carcinoma has spread to adjacent pelvic organs. (FIGO 2018)


Grade 1 Ileum Stricture or Stenosis, CTCAE


Grade 2 Rash Hand or Foot Skin Reaction, CTCAE


Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Bronchospasm, CTCAE

A disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall.


Grade 3 Nasal Cavity Intra-Operative Injury, CTCAE


Grade 3 Parathyroid Intra-Operative Injury, CTCAE


Grade 3 Rectal Fistula, CTCAE

Invasive intervention indicated


Unresectable Digestive System Neuroendocrine Tumor G2

Digestive system neuroendocrine tumor G2 that is not amenable to surgical resection.


Incontinent Epispadias

Epispadias with urinary incontinence.


Acute Myeloid Leukemia with Variant MLL Translocations

A term referring to acute myeloid leukemias with rearrangement of the KMT2A gene that results in translocations with various genes other than the MLLT3 (AF9) gene.


Chylous Ascites, CTCAE

A disorder characterized by accumulation of milky fluid in the peritoneal cavity.


Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Erythema Multiforme, CTCAE

Target lesions covering <10% BSA and not associated with skin tenderness


Gestational Trophoblastic Tumor by AJCC v7 Stage

A term that refers to the staging of gestational trophoblastic tumor according to the American Joint Committee on Cancer, 7th edition.


Grade 4 Urinary Tract NOS Intra-Operative Injury, CTCAE


Grade 4 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Intraoperative Respiratory Injury, CTCAE

Partial resection of injured organ/structure indicated


Sinus Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses.


Grade 3 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Superficial Thrombophlebitis, CTCAE

A disorder characterized by a blood clot and inflammation involving a superficial vein of the extremities.


Hypoalbuminemia, CTCAE

A disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood.


Grade 2 Pulmonary Vein Intra-Operative Injury, CTCAE


Grade 2 Induration or Fibrosis of the Skin and Subcutaneous Tissue, CTCAE


Grade 3 Dental Caries, CTCAE

Dental caries resulting in pulpitis or periapical abscess or resulting in tooth loss


Grade 1 Ventricular Arrhythmia, CTCAE

Asymptomatic, intervention not indicated


Grade 5 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Epstein-Barr Virus Infection Reactivation, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated


Gastrointestinal Carcinomatosis

Carcinoma that has spread diffusely to the gastrointestinal system.


Allergic contact dermatitis caused by Arnica

Dermatitis caused by an allergic reaction to arnica.


Grade 4 Fallopian Tube Perforation, CTCAE

Life-threatening consequences; urgent operative intervention indicated (e.g., organ resection)


Other Musculoskeletal and Soft Tissue, CTCAE


Indolent T-cell lymphoproliferative disorder of gastrointestinal tract

A clonal T-cell lymphoproliferative disorder that can involve the mucosa in all sites of the gastrointestinal tract, but is most common in the small intestine and colon. The lymphoid cells infiltrate the lamina propria but usually do not show invasion of the epithelium. The clinical course is indolent, but most patients do not respond to conventional chemotherapy. A subset of cases progress to a higher-grade T-cell lymphoma with spread beyond the gastrointestinal tract. (WHO 2017)


Grade 1 Fracture, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Acute Myeloid Leukemia with BCOR Mutation

An acute myeloid leukemia associated with BCOR gene mutation.


Advanced Malignant Genitourinary System Neoplasm

A malignant genitourinary neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refluxing Obstructed Megaureter

A megaureter in which there is retrograde flow of urine and a concomitant, episodic obstruction resulting from ureteral folding.


Uterine Corpus Germ Cell Tumor

A benign or malignant germ cell tumor that arises from the uterine corpus. Representative examples include teratoma and yolk sac tumor.


Enterocolitis Infectious, CTCAE

A disorder characterized by an infectious process involving the small and large intestines.


Postneoadjuvant Therapy Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage I includes: T0-2, N0, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Prostate Adenocarcinoma by AJCC v7 Stage

A term that refers to the staging of prostate adenocarcinoma according to the American Joint Committee on Cancer, 7th edition.


Non-Neoplastic Appendix Disorder

A non-neoplastic disorder that affects the appendix.


Grade 4 Testis Intra-Operative Injury, CTCAE


Grade 3 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Skin Hyperpigmentation, CTCAE

Hyperpigmentation covering <10% BSA; no psychosocial impact


Lymphoproliferative Disorder of the Skin

A lymphoproliferative disorder that affects the skin.


Diffuse Astrocytoma, MYB-Altered

A rare IDH-and H3-wildtype diffuse astrocytoma characterized by the presence of a monomorphic population of neoplastic cells that exhibit alteration in the MYB gene. This alteration is associated with fusion between MYB gene and a partner gene, usually PCDHGA1, MMP16, and MAML2 genes.


Tooth Discoloration, CTCAE

A disorder characterized by a change in tooth hue or tint.


Encephalomyelitis Infection, CTCAE

A disorder characterized by an infectious process involving the brain and spinal cord tissues.


Right Ventricular Dysfunction, CTCAE

A disorder characterized by impairment of right ventricular function associated with low ejection fraction and a decrease in motility of the right ventricular wall.


Benign Intracranial Meningioma

A grade I, slowly growing meningioma within the cranial cavity.


Grade 3 Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Fever Without Neutropenia, CTCAE


Isolated Non-Pigmented Micronodular Adrenal Hyperplasia

A subtype of micronodular adrenal hyperplasia, characterized by multiple non-pigmented nodules.


Metastatic Endometrial Clear Cell Adenocarcinoma

Endometrial clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


Fallopian Tube Cancer by AJCC v7 Stage

A term that refers to the staging of fallopian tube carcinoma according to the American Joint Committee on Cancer, 7th edition.


Type E Lymphomatoid Papulosis

A variant of lymphomatoid papulosis characterized by the presence of atypical lymphocytes which exhibited distinct angioinvasion.


Grade 2 Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Upper aerodigestive tract infection

An infectious process affecting the oral cavity, pharynx, and/or larynx.


Benign neoplasm of lymph vessels

A benign neoplasm arising from the lymphatic vessels.


Grade 2 Urostomy Site Bleeding, CTCAE

Moderate bleeding; medical intervention indicated


Coup de sabre scleroderma

A type of linear scleroderma characterized by a linear, colorless, atrophied band across the forehead or scalp. This disorder can affect the tissues under or near the lesion including brain, bone and eyes.


Unexpected Adverse Event

Any adverse event associated with a medical product or procedure that has not been previously observed, whether or not the event was anticipated because of the pharmacologic properties of the study agent or the nature of the medical procedure. This includes events that are more serious than expected or occur more frequently than expected, particularly, any adverse experience, the nature, severity or frequency of which is not consistent with the product label, or with the current investigator brochure for investigational agent; or with the risk information described in the investigational plan or protocol or consent form.


Grade 3 Ejection Fraction Decreased, CTCAE

Resting ejection fraction (EF) 39-20%; >=20% drop from baseline


Grade 2 Flushing, CTCAE

Moderate symptoms; limiting instrumental ADL


Cranial Nerve XII Intra-Operative Injury, CTCAE


Vulvar Merkel Cell Carcinoma

A Merkel cell carcinoma that arises from the vulva. It usually presents as a cutaneous nodular lesion. Most small cell neuroendocrine carcinomas of the vulva are Merkel cell carcinomas.


Leukemia, Eosinophilic, Acute

A poorly defined concept which at best is described as an extremely rare entity, possibly related to various subtypes of acute myeloid leukemia with abnormal eosinophils.  (WHO, 2001)


Stage IA Bone Cancer AJCC v8

Stage IA includes: T1, N0, M0, G1 or GX. T1: Tumor measuring 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


Chondroblastoma, malignant

A rare chondroblastoma that has metastasized to another anatomic site.


Grade 5 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Human Papillomavirus-Related Cervical Adenocarcinoma In Situ

Cervical adenocarcinoma in situ associated with human papillomavirus infection.


Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE


Grade 1 Fallopian Tube Perforation, CTCAE


Condyloma acuminata of vagina

A human papillomavirus-related neoplasm that arises from the vagina. It is characterized by papillomatosis, acanthotic changes, and hyperkeratosis. Koilocytosis is usually present.


Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


Disease due to Papovaviridae

An infection caused by any papovavirus.


Lugano Classification Stage IIE Childhood Hodgkin Lymphoma AJCC v8

Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Grade 3 Neonatal Respiratory Insufficiency, AE

An adverse event in a newborn characterized by clinical evidence of increased respiratory distress with relevant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); requiring major care change (e.g. starting invasive support).


Melanoma Metastatic in the Brain

A melanoma that has spread to the brain from its original site of growth, through the hematogenous route.


Vaginal high grade squamous intraepithelial lesion

Vaginal intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes.


Stage II Low Grade Adult Non-Hodgkin's Lymphoma


Grade 5 Neonatal Constipation, AE

A constipation adverse event in a newborn which results in death.


autosomal recessive dyskeratosis congenita 2

Dyskeratosis congenita caused by autosomal recessive mutation(s) in the NHP2 gene, encoding H/ACA ribonucleoprotein complex subunit 2.


Grade 2 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Urinary Tract Pain, CTCAE

Moderate pain; limiting instrumental ADL


Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage

A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the Toronto childhood cancer staging guidelines v2.


Grade 5 Large Intestinal Anastomotic Leak, CTCAE

Death


Grade 5 Acute Vascular Leak Syndrome, CTCAE


Grade 3 Nervous System Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Facial Muscle Weakness, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


AIDS-Related Human Papillomavirus Infection

An opportunistic infection caused by the human papillomavirus in a patient with AIDS.


Stage III Fallopian Tube Cancer AJCC v7

Stage III includes: (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c, N0, M0); (Any T, N1, M0).  T3: Tumor involves one or both fallopian tubes, with peritoneal implants outside the pelvis.  T3a: Microscopic peritoneal metastasis outside the pelvis.  T3b: Macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis outside the pelvis and more than 2 cm in diameter.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 5 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Bronchopulmonary Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


small cell carcinoma of anal canal

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal.  It is characterized by the presence of malignant small cells.


Grade 5 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

Death


Chest Pain Along Left Lower Sternal Border

The location of the chest pain is along the left lower border of the sternum.


Grade 3 Typhlitis, CTCAE

Symptomatic (e.g., abdominal pain, fever, change in bowel habits with ileus); peritoneal signs


Recurrent Mesonephric Adenocarcinoma

The reemergence of mesonephric adenocarcinoma after a period of remission.


Mixed cell adenocarcinoma

An adenocarcinoma characterized by the presence of a mixed malignant glandular cell population.


Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma

Renal pelvis and ureter urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage III Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 3 Stridor, CTCAE

Respiratory distress limiting self care ADL; medical intervention indicated


Grade 3 Thyroid Intra-Operative Injury, CTCAE


Grade 2 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Social Circumstances - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Common Carotid Trunk

Common origin for left subclavian and left carotid arteries.


Central Nervous System Rosai-Dorfman Disease

Rosai-Dorfman-Destombes disease affecting the central nervous system. It presents with localized or multiple dural masses, parenchymal, and/or intrasellar lesions.


Malignant tumor of seminal vesicle

A primary or metastatic malignant neoplasm that affects the seminal vesicle.


Duodenal Fistula, CTCAE

A disorder characterized by an abnormal communication between the duodenum and another organ or anatomic site.


Grade 4 Lower Extremity Artery Injury, CTCAE


Grade 3 Gastrointestinal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Stage IIIC2 Cervical Cancer FIGO 2018

Cervical carcinoma with para-aortic lymph node metastasis. (FIGO 2018)


Definite Adverse Event Attribution to Product or Procedure

Definite adverse event attribution to study product or procedure is established when there is a clear-cut temporal association between product or procedure administration and adverse event, and no other possible cause is present.


Grade 3 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Gallbladder Cancer by AJCC v8 Stage

A term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to gallbladder carcinomas. Well-differentiated neuroendocrine tumors and sarcomas are not staged using this staging system. (from AJCC 8th Ed.)


Grade 1 Intraoperative Head and Neck Injury, CTCAE

Primary repair of injured organ/structure indicated


Stage I Vaginal Cancer AJCC v6 and v7

Stage I includes: (T1, N0, M0).  T1: Tumor confined to vagina.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 2 External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Stoma Site Infection, CTCAE

Death


Grade 5 Cranial Nerve IV Neuropathy, CTCAE


Grade 2 Prostate Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage 0 Uterine Corpus Cancer AJCC v6

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Bronchus Infection with Unknown Absolute Neutrophil Count, CTCAE


Leptomeningeal Neoplasms

A malignant neoplasm that has spread from its original site to the two innermost layers of tissue that cover the brain and spinal cord.


Grade 3 Tracheal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Secondary Osteosarcoma

An osteosarcoma arising from a pre-existing lesion of the bone, usually Paget disease, or due to radiation therapy.


Grade 4 Cranial Nerve V Motor Intra-Operative Injury, CTCAE


Grade 2 Dermatitis Radiation, CTCAE

Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema


Grade 4 Liver Dysfunction or Failure by Clinical Classification, CTCAE


Grade 1 Rectal Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Grade 5 Gallbladder Perforation, CTCAE

Death


Refractory Primary Malignant Central Nervous System Neoplasm

A primary malignant central nervous system neoplasm that is resistant to treatment.


Grade 5 Small Bowel Stricture or Stenosis NOS, CTCAE


Grade 4 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Laryngeal Edema, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 1 Oral Intra-Operative Injury, CTCAE


Grade 2 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic Pancreatic Squamous Cell Carcinoma

Pancreatic squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


Grade 4 Delirium, CTCAE

Life-threatening consequences, threats of harm to self or others; urgent intervention indicated


Grade 1 Peritoneal Cavity Hemorrhage, CTCAE


Grade 3 Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage M4 Childhood Ependymoma by Toronto Guidelines v2

Metastasis outside of the central nervous system. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 3 Meningitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated; focal neurologic deficit


Grade 2 Bladder Stricture or Stenosis, CTCAE


Grade 5 Jejunal Ulcer, CTCAE

Death


Hypertensive episode

An episode of elevated blood pressure.


Grade 3 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 4 Prolonged Intubation After Pulmonary Resection, CTCAE


Grade 4 Heart Failure, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support)


Grade 3 Metabolic or Respiratory Acidosis, CTCAE


Grade 1 Cartilage Intra-Operative Injury, CTCAE


Refractory Chemotherapy-Induced Nausea and Vomiting

Chemotherapy-induced nausea and vomiting that does not respond to treatment.


Grade 3 Nails Intra-Operative Injury, CTCAE


Congenital Phrenic Nerve Injury

Damage to the phrenic nerve that is present at birth.


Conjunctival Reactive Epithelial Hyperplasia

A non-neoplastic proliferation of the conjunctival epithelium in response to irritating stimuli.


Bladder Perforation, CTCAE 5.0

A disorder characterized by a rupture in the bladder wall.


Muscle Invasive Bladder Carcinoma

A carcinoma that arises from the bladder mucosa and invades the muscle of the bladder wall.


Tearing Pain

An intense sensation of discomfort or distress that feels like being torn or ripped apart.


Stage IIA Appendix Carcinoma AJCC v8

Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Increased Creatinine

A laboratory test result demonstrating an increased concentration of creatinine in a biological specimen.


Childhood Non-T Non-B Acute Lymphoblastic Leukemia

Non-T non-B acute lymphoblastic leukemia that occurs during childhood.


Grade 4 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Acute Myeloid Leukemia with Myelodysplasia-Related Cytogenetic Abnormalities

A group of acute myeloid leukemias classified based on specific karyotype findings.


Grade 1 Somnolence, CTCAE

Mild but more than usual drowsiness or sleepiness


Non-organic enuresis

Involuntary urine release that cannot be attributed to an anatomic or physiologic etiology.


Malignant Trophoblastic Teratoma

A malignant germ cell tumor which metastasizes widely and produces high levels of human chorionic gonadotropin.


Disturbance of Temperature Regulation

Any condition characterized by an inability to regulate body temperature.


Grade 2 Hepatic Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Puerperal sepsis

A sustained temperature of 38C (100.4F) or greater beyond the first 24 hours following birth, or a temperature of 39C (102.2F) within the first 24 hours following birth. (adapted from ACOG)


Grade 5 Bone Infection, CTCAE

Death


Non-Destructive Post-Transplant Lymphoproliferative Disorder

A lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by the lack of tissue destruction and the architectural preservation of the involved tissues.  It includes two morphologic variants: plasmacytic hyperplasia and infectious mononucleosis-like lymphoproliferative disorders.


Grade 3 Metabolic or Respiratory Alkalosis, CTCAE


Non-T Non-B CALLA Positive Childhood Acute Lymphoblastic Leukemia

A non-T, non-B, acute lymphoblastic leukemia in which the lymphoblasts are positive for the common acute lymphoblastic leukemia antigen (CALLA) occurring in children.


Fibrosarcoma metastatic

Fibrosarcoma that has spread from its original site of growth to another anatomic site.


Grade 2 Small Intestinal Stenosis, CTCAE

Symptomatic; altered GI function


Grade 3 Uterus Intra-Operative Injury, CTCAE


Dermatitis Radiation, CTCAE

A finding of cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation.


Gallbladder Papillary Biliary Intraepithelial Neoplasia

Biliary intraepithelial neoplasia that affects the gallbladder epithelium.  It is characterized by the presence of intraluminal micropapillary projections.


Stage III Cutaneous Melanoma AJCC v6

Stage III includes: (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  N1: Metastasis in one lymph node.  N2: Metastasis in two to three regional lymph nodes or intralymphatic regional metastasis without nodal metastases.  N3: Metastasis in four or more regional nodes, or matted metastatic nodes, or in-transit metastasis or satellite(s) with metastasis in regional node(s).


Neuroendocrine carcinoma of prostate

A small cell or rarely a large cell neuroendocrine carcinoma that arises from the prostate gland.


Grade 4 Cranial Nerve V Neuropathy, CTCAE


Grade 3 Paroxysmal Atrial Tachycardia, CTCAE

Symptomatic, urgent intervention indicated; ablation


Developmental and Epileptic Encephalopathy 47

An autosomal dominant subtype of developmental and epileptic encephalopathy, caused by mutation(s) in the FGF12 gene, encoding fibroblast growth factor 12.


Recurrent Urothelial Carcinoma of the Renal Pelvis and Ureter

The reemergence of renal pelvis and ureter urothelial carcinoma after a period of remission.


Grade 4 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Grade 3 Oral Cavity Fistula, CTCAE

Invasive intervention indicated


Injury To Superior Vena Cava, CTCAE

A finding of damage to the superior vena cava.


Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Breast Function and Lactation, CTCAE


Malignant sex-cord stromal tumor

A gonadal sex cord-stromal tumor with malignant characteristics.  It includes the poorly differentiated ovarian Sertoli-Leydig cell tumor, malignant ovarian granulosa cell tumor, malignant ovarian steroid cell tumor, and malignant ovarian thecoma.


Polygonal cell carcinoma

A malignant epithelial neoplasm composed of atypical polygonal cells with a large amount of eosinophilic cytoplasm. A representative example is the fibrolamellar hepatocellular carcinoma.


Gastritis, CTCAE

A disorder characterized by inflammation of the stomach.


Grade 5 Hypertension, CTCAE

Death


Grade 1 Neonatal Gastrointestinal Bleeding, AE

A gastrointestinal bleeding adverse event in a newborn characterized by mild, self-limiting, bleeding; no change in care required.


Myocarditis, CTCAE 5.0

A disorder characterized by inflammation of the muscle tissue of the heart.


Grade 2 Adrenal Gland Intra-Operative Injury, CTCAE


Grade 1 Cough, CTCAE

Mild symptoms; nonprescription intervention indicated


Grade 3 Hepatic Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 Inner Ear Intra-Operative Injury, CTCAE


Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Cartilage Intra-Operative Injury, CTCAE


IgG Monoclonal Gammopathy

An abnormal laboratory test result indicating the presence of IgG monoclonal immunoglobulin in the blood or urine.


Grade 2 Infant Irritability, AE

An adverse event in a newborn characterized by moderate irritability, minor changes in feeding and sleeping behavior, requiring minor additional care (e.g. occasional analgesics).


Grade 3 Testis Intra-Operative Injury, CTCAE


Grade 5 Bronchus Obstruction and Stenosis, CTCAE


Grade 4 Hypoglycemia, CTCAE

<30 mg/dL; <1.7 mmol/L; life-threatening consequences; seizures


Recurrent Pancreatic Acinar Cell Carcinoma

The reemergence of pancreatic acinar cell carcinoma after a period of remission.


Infestation

Invasion of the body by complex organisms that are typically non-microscopic such as worms and arthropods.


Grade 2 Hemorrhoids, CTCAE

Symptomatic; banding or medical intervention indicated


Grade 5 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

Death


Recurrent Malignant Peripheral Nerve Sheath Tumor

The reemergence of malignant peripheral nerve sheath tumor after a period of remission.


Grade 4 Vaginal Perforation, CTCAE

Life-threatening consequences; urgent intervention indicated


Retinal Pigment Epithelium Adenocarcinoma

An adenocarcinoma that arises from the retinal pigment epithelium. The prognosis is good if the tumor has not extended extraocularly.


Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-MLL

An acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A occurring in adults.


Grade 5 Non-Myocardial Visceral Arterial Ischemia, CTCAE


Grade 1 Hemoglobin Increased, CTCAE

Increase in >0-2 g/dL


Lugano Classification Stage II Hodgkin Lymphoma AJCC v8

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Biliary Fistula, CTCAE

A disorder characterized by an abnormal communication between the bile ducts and another organ or anatomic site.


Grade 1 Parathyroid Intra-Operative Injury, CTCAE


Worst Imaginable Pain

The most severe pain an individual can conceive of experiencing.


Refractory Pancreatic Carcinoma

Pancreatic carcinoma that does not respond to treatment.


Lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Clinical Stage IIB Cutaneous Melanoma AJCC v8

Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0). T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Locally Advanced Basal Cell Carcinoma

A basal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Brain Ependymoma

An ependymoma that arises from the brain.


T-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant

A T-cell prolymphocytic leukemia characterized by the presence of neoplastic prolymphocytes with irregular or cerebriform nuclear outline.


Grade 1 Dental Caries, CTCAE

One or more dental caries, not involving the root


Grade 3 Uterine Obstruction, CTCAE

Severe symptoms; invasive intervention indicated


Gliomatosis Cerebri Type II

A classic form of gliomatosis cerebri. It is characterized by diffuse growth of neoplastic glial tissue without any focal mass.


Grade 2 Hoarseness, CTCAE

Moderate or persistent voice changes; may require occasional repetition but understandable on telephone; medical evaluation indicated


Adnexal Secretory Carcinoma

A rare adnexal carcinoma that is histopathologically identical to homologous lesions in the salivary gland and breast. (WHO 2018)


Grade 5 Biliary Anastomotic Leak, CTCAE

Death


Decreased or absent activity of the enzyme 17-alpha-hydroxylase/17,20 lyase due to loss-of-function mutation(s) in the CYP17A1 gene. The clinical manifestations of the deficiency are dependent on whether one or both activities of the enzyme are affected, and may include hypertension due to reduced 17-hydroxylase activity and incomplete genital masculinization in 46,XY infants due to reduced 17,20 lyase activity.


Grade 1 Rectum Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Malignant hepatobiliary neoplasms

A malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder.  Representative examples include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Grade 5 Anemia, CTCAE

Death


Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE


Stage III Bladder Cancer AJCC v8

Stage III includes: IIIA: (T3a, T3b, T4a, N0, M0); (T1-T4a, N1, M0); IIIB: (T1-T4a, N2, N3, M0). T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T3a: Tumor invades perivesical soft tissue, microscopically. T3b: Tumor invades perivesical soft tissue, macroscopically (extravesical mass). T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node). N2: Multiple regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node metastasis). N3: Lymph node metastasis to the common iliac lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Temporal lobe sclerosis

A neurological condition caused by scarring and degeneration of the temporal lobe. It is characterized by cognitive and behavioral symptoms, and focal epilepsy.


Grade 4 Hypercalcemia, CTCAE

Corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences


Proliferative retinopathy

Retinopathy characterized by the formation of new vessels in the retina. The new vessels are abnormal and fragile. If hemorrhage occurs due to the vascular fragility, there is increased risk of vision loss or blindness.


Grade 5 Duodenal Obstruction, CTCAE

Death


Neonatal aspiration of amniotic fluid

Inhalation of fluid from the amniotic sac into the lungs by the neonate.


Grade 3 Duodenum Stricture or Stenosis, CTCAE


Grade 4 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Childhood Perineurioma

A perineurioma that occurs during childhood.


Acquired postural kyphosis

Postural kyphosis, the cause of which is not present at birth.


Cardiac Troponin T Increased, CTCAE

A finding based on laboratory test results that indicate increased levels of cardiac troponin T in a biological specimen.


squamous cell papilloma of anal canal

A benign epithelial neoplasm that arises from the anal canal.  It is characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy.


Grade 5 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Rectal Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the rectal wall.


Refractory Fallopian Tube Undifferentiated Carcinoma

Fallopian tube undifferentiated carcinoma that is resistant to treatment.


Major Visceral Vein Intra-Operative Injury, CTCAE


Grade 2 Portal Vein Thrombosis, CTCAE

Intervention not indicated


Recurrent Epithelioid Malignant Peripheral Nerve Sheath Tumor

The reemergence of an epithelioid malignant peripheral nerve sheath tumor after a period of remission.


Grade 3 Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Gastrointestinal Stoma Obstruction, CTCAE


Grade 4 Nose Intra-Operative Injury, CTCAE


Grade 1 Intraoperative Endocrine Injury, CTCAE

Primary repair of injured organ/structure indicated


Stage II Gestational Trophoblastic Tumor AJCC v7

Stage II includes: (T2, M0, Risk factors: unknown); IIA (T2, M0, Risk factors: low risk); IIB (T2, M0, Risk factors: high risk).  T2: Tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 1 Laryngeal Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Fallopian Tube Stricture or Stenosis, CTCAE


Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Skin Induration, CTCAE

Generalized; associated with signs or symptoms of impaired breathing or feeding


Grade 3 Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE