Recurrent Oligoastrocytoma

The reemergence of oligoastrocytoma after a period of remission.


Pancreatic Mixed Ductal-Neuroendocrine Neoplasm

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A rare mixed neuroendocrine non-neuroendocrine neoplasm that arises from the pancreas and is composed of ductal adenocarcinoma and a neuroendocrine neoplastic component. The latter is usually a poorly differentiated neuroendocrine carcinoma and rarely a well differentiated neuroendocrine tumor.


Testicular Mixed Yolk Sac Tumor and Teratoma

A malignant non-seminomatous germ cell tumor arising from the testis.  It is characterized by a mixture of yolk sac and teratomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


Malignant Submandibular Gland Mixed Tumor

A malignant tumor arising from the submandibular gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Benign Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm

A non-metastasizing neoplasm that arises from the uterine corpus and is composed of epithelial and mesenchymal elements. Representative examples include adenomyoma and adenofibroma.


Testicular Mixed Yolk Sac Tumor and Teratoma with Seminoma

A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of yolk sac, teratomatous, and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


Mixed Carcinoma

A carcinoma characterized by the presence of more than one malignant epithelial histologic pattern.


Stage IVB Uterine Corpus Adenosarcoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Recurrent Cervical Adenosquamous Carcinoma

The reemergence of cervical adenosquamous carcinoma after a period of remission.


Stage IB Uterine Corpus Adenosarcoma AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Uterine corpus adenosarcoma with tumor invading to less than half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Recurrent Primary Peritoneal Carcinosarcoma

The reemergence of primary peritoneal carcinosarcoma after a period of remission.


Malignant Mixed Tumor, Not Otherwise Specified

A malignant myoepithelioma characterized by the presence of a minor ductal component.


Childhood Anaplastic Oligoastrocytoma

An anaplastic oligoastrocytoma that occurs during childhood.


Childhood Breast Fibroadenoma

A fibroadenoma that arises from the breast and occurs during childhood.


Ampulla of Vater Mixed Adenoneuroendocrine Carcinoma

A carcinoma that arises from the ampulla of Vater and the periampullary region. It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Childhood Mixed Glioma

A mixed glioma that occurs during childhood.


Stage II Uterine Corpus Adenosarcoma AJCC v8

Stage II includes: T2, N0, M0. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


adenosquamous carcinoma of tongue

A rare adenosquamous carcinoma that arises from the tongue.


Testicular Mixed Embryonal Carcinoma and Seminoma

A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a mixture of embryonal carcinoma and a seminomatous component.


Refractory Uterine Corpus Carcinosarcoma

Uterine Corpus Carcinosarcoma that is resistant to treatment.


Advanced Carcinosarcoma

Carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Choriocarcinoma combined with other germ cell elements

A malignant mixed germ cell tumor characterized by the presence of a choriocarcinomatous component admixed with another germ cell component (e.g. embryonal carcinoma, teratoma, or seminoma).


Recurrent Endometrial Adenosquamous Carcinoma

The reemergence of endometrial adenosquamous carcinoma after a period of remission.


Malignant Vaginal Mixed Tumor Resembling Synovial Sarcoma

A very rare malignant mixed epithelial and mesenchymal neoplasm that arises from the vagina and resembles synovial sarcoma.  It is characterized by a biphasic pattern and is composed of gland-like structures that are lined by epithelial cells and a cellular mesenchymal component.


Malignant Parotid Gland Mixed Tumor

A malignant tumor arising from the parotid gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Odontogenic Carcinosarcoma

An extremely rare malignant mixed odontogenic neoplasm in which both the epithelial and the mesenchymal components are cytologically malignant. (WHO 2017)


Invasive Bladder Mixed Carcinoma

An invasive bladder carcinoma characterized by the presence of more than one histologic pattern.


Human Papillomavirus-Related Adenosquamous Carcinoma

An adenosquamous carcinoma associated with the presence of human papillomavirus infection.


Esophageal Mixed Adenoneuroendocrine Carcinoma

A carcinoma that arises from the esophagus and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Vaginal Adenosquamous Carcinoma

A carcinoma that arises from the vagina and is characterized by the presence of malignant glandular and malignant squamous epithelial components.


Laryngeal Pleomorphic Adenoma

A very rare pleomorphic adenoma that arises from the larynx.


Stage IVA Uterine Corpus Adenosarcoma AJCC v8

Stage IVA includes: T4, Any N, M0. T4: Uterine corpus adenosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Mixed Tumor, Not Otherwise Specified

A benign myoepithelioma characterized by the presence of a minor ductal component.


Vulvar Composite Hidradenoma Papilliferum and Fibroadenoma

A benign composite neoplasm that arises from the vulva and is characterized by mixed histopathologic features of hidradenoma papilliferum and fibroadenoma.


Testicular Mixed Embryonal Carcinoma and Yolk Sac Tumor

A malignant non-seminomatous germ cell tumor arising from the testis.  It is characterized by a mixture of embryonal carcinoma and yolk sac morphologic elements.  Patients may present with painless or painful testicular swelling.


Pancreatic Mixed Acinar-Ductal Neuroendocrine Carcinoma

A very rare carcinoma that arises from the pancreas showing a mixture of acinar, neuroendocrine, and ductal carcinoma elements.


Trichoblastic Carcinosarcoma

A rare biphasic follicular neoplasm consisting of a malignant epithelial component resembling follicular germinative cells closely associated with a malignant stromal component differentiating towards specific follicular mesenchyme. (WHO 2018)


Metastatic Digestive System Mixed Adenoneuroendocrine Carcinoma

Mixed adenoneuroendocrine carcinoma that arises from the digestive system and has metastasized to other anatomic sites.


Hybrid nerve sheath tumor

A benign nerve sheath tumor characterized by the combination of histologic features seen in schwannomas, neurofibromas, and perineuriomas.


Pleomorphic adenoma of lacrimal gland

A benign, usually encapsulated neoplasm of the lacrimal gland composed of epithelial and mesenchymal cells.  Pleomorphic adenomas are neoplasms that develop in the salivary glands or heterotopic salivary gland tissues.  It has been suggested that myoepithelial cells play a major role in the histogenesis of these tumors.  In the lacrimal gland, pleomorphic adenomas presumably develop from metaplastic myoepithelial cells.


Malignant Mixed Tumor of the Minor Salivary Gland

A malignant tumor arising from the minor salivary glands.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Seminal Vesicle Mixed Epithelial and Stromal Tumor

A rare biphasic neoplasm that arises from the seminal vesicle. It is characterized by the presence of stromal and benign epithelial components. Rarely, the stromal component may display atypia and mitotic activity and the tumor may behave in a malignant clinical course.


Soft Palate Pleomorphic Adenoma

A benign, slow-growing and painless neoplasm that arises from the minor salivary glands in the soft palate.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


Breast Pleomorphic Adenoma

A rare, benign and well circumscribed neoplasm that arises from the breast.  It is characterized by the proliferation of epithelial and myoepithelial cells surrounded by chondroid stroma.


Stage IC Uterine Corpus Adenosarcoma AJCC v8

Stage IC includes: T1c, N0, M0. T1c: Uterine corpus adenosarcoma with tumor invading more than half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IV Uterine Corpus Adenosarcoma AJCC v8

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus adenosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Metastatic Malignant Mixed Mesodermal (Mullerian) Tumor

A malignant mixed mesodermal (Mullerian) tumor that has spread from its original site of growth to another anatomic site.


Recurrent Uterine Corpus Carcinosarcoma

The reemergence of uterine corpus carcinosarcoma after a period of remission.


Parotid Gland Carcinosarcoma

An aggressive, high grade malignant tumor that arises from the parotid gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Gallbladder Mucinous Cystic Neoplasm, High Grade

A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of severe atypia.


Vulvar Adenocarcinoma of Mammary Gland Type

A primary invasive malignant epithelial neoplasm of the vulva showing morphological features of recognized breast adenocarcinomas. (WHO, 2014)


Vulvar Adenocarcinoma, Intestinal-Type

A rare adenocarcinoma of intestinal type that arises from the vulva. The morphological features are those of a mucinous adenocarcinoma.


Fetal Scalp Laceration

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Grade 2 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Left Ventricular Diastolic Dysfunction, CTCAE


biotins

Compounds containing a biotin (5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid) skeleton.


A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.


Grade 3 Peripheral Motor Neuropathy, CTCAE

Severe symptoms; limiting self care ADL


Grade 1 Testicular Pain, CTCAE

Mild pain


Grade 3 Bladder Spasm, CTCAE

Hospitalization indicated


Grade 3 Venous Injury, CTCAE

Severe symptoms; limiting self care ADL; repair or revision indicated


Grade 2 Delayed Orgasm, CTCAE

Delay in achieving orgasm adversely affecting relationship


Cervical Squamotransitional Carcinoma

A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures with fibrovascular cores. It is covered with multiple layers of atypical cells that resemble cervical intraepithelial neoplasia 3.


Grade 2 Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program, CTCAE


Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program, CTCAE


Grade 3 Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program, CTCAE


Grade 4 Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program, CTCAE


Grade 1 Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program, CTCAE


Grade 3 Salivary Duct Inflammation, CTCAE

Acute salivary gland necrosis; severe secretion-induced symptoms (e.g., thick saliva/oral secretions or gagging); tube feeding or TPN indicated; limiting self care ADL


Transformed migraine

Episodes of migraine occurring on 15 or more days per month, for more than three months.


Grade 4 Cranial Nerve III Neuropathy, CTCAE


A reactive proliferation of the conjunctival epithelium associated with the presence of prominent glandular elements.


Spinal arthritis deformans

Degenerative arthritis of the spinal column.


Amyotrophic Lateral Sclerosis 14, With or Without Frontotemporal Dementia

A form of amyotrophic lateral sclerosis caused by heterozygous mutation(s) in the VCP gene, encoding transitional endoplasmic reticulum ATPase.


chronic inflammatory demyelinating polyneuritis

An immunologic inflammatory disorder characterized by loss of myelin in the peripheral nerves. Patients present with progressive weakness and loss of sensory function in the legs and arms.


Spastic Paraplegia 30

An autosomal recessive subtype of hereditary spastic paraplegia caused by mutation(s) in the KIF1A gene, encoding kinesin-like protein KIF1A.


Presenile dementia

The presence of dementia in an individual younger than age sixty five.


Amyotrophic Lateral Sclerosis 25

An autosomal dominant form of amyotrophic lateral sclerosis caused by mutation(s) in the KIF5A gene, encoding kinesin heavy chain isoform 5A.


Spastic Paraplegia 76

An autosomal recessive subtype of hereditary spastic paraplegia caused by mutation(s) in the CAPN1 gene, encoding calpain-1 catalytic subunit.


Grade 3 Gynecomastia, CTCAE

Severe symptoms; elective operative intervention indicated


Grade 2 Gynecomastia, CTCAE

Symptomatic (e.g., pain or psychosocial impact)


Grade 1 Ligament Intra-Operative Injury, CTCAE


Unresectable Pancreatic Neuroendocrine Tumor G3

Pancreatic neuroendocrine tumor G3 that is not amenable to surgical resection.


Grade 3 Skin Atrophy, CTCAE

Covering >30% BSA; associated with ulceration


Adult Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11

An acute myeloid leukemia with inv(16)(p13.1q22); CBFB-MYH11 occurring in adults.


Grade 5 Postoperative Thoracic Procedure Complication, CTCAE

Death


Grade 2 Arthritis, CTCAE

Moderate pain associated with signs of inflammation, erythema, or joint swelling; limiting instrumental ADL


Musculoskeletal and Connective Tissue Disorders, CTCAE


Grade 2 Neck Soft Tissue Necrosis, CTCAE

Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Muscle Cramp, CTCAE

A disorder characterized by marked cramping sensation originating from a muscle or group of muscles.


Grade 3 Muscle Weakness Lower Limb, CTCAE

Limiting self care ADL


Grade 3 Arthralgia, CTCAE

Severe pain; limiting self care ADL


Arthritis, CTCAE

A disorder characterized by inflammation involving a joint.


Grade 1 Avascular Necrosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Unequal Limb Length, CTCAE

Severe length discrepancy >5 cm; limiting self care ADL; operative intervention indicated


Grade 3 Scoliosis, CTCAE

>45 degrees; scapular prominence in forward flexion; operative intervention indicated; limiting self care ADL


Grade 3 Joint Range of Motion Decreased Cervical Spine, CTCAE

Ankylosed/fused over multiple segments with no C-spine rotation


Grade 3 Muscle Weakness Upper Limb, CTCAE

Limiting self care ADL


Grade 3 Soft Tissue Necrosis Upper Limb, CTCAE

Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)


Grade 2 Osteonecrosis of Jaw, CTCAE

Symptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL


Grade 3 Chest Wall Pain, CTCAE

Severe pain; limiting self care ADL


Grade 4 Soft Tissue Necrosis Upper Limb, CTCAE

Life-threatening consequences; urgent intervention indicated


Joint Effusion, CTCAE 5.0

A disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation.


Joint Range of Motion Decreased, CTCAE

A disorder characterized by a decrease in joint flexibility of any joint.


Grade 1 Pain In Extremity, CTCAE

Mild pain


Kyphosis, CTCAE

A disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine.


Grade 3 Pain In Extremity, CTCAE

Severe pain; limiting self care ADL


Grade 2 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 2 Exostosis, CTCAE

Symptomatic; limiting instrumental ADL


Trismus, CTCAE

A disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication.


Grade 1 Rotator Cuff Injury, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 1 Unequal Limb Length, CTCAE

Mild length discrepancy <2 cm


Grade 1 Myositis, CTCAE

Mild pain


Rotator Cuff Injury, CTCAE

A disorder characterized by an injury of the rotator cuff.


Grade 1 Musculoskeletal Deformity, CTCAE

Cosmetically and functionally insignificant hypoplasia


Myositis, CTCAE 5.0

A disorder characterized by inflammation involving the skeletal muscles.


Grade 5 Pelvic Soft Tissue Necrosis, CTCAE

Death


Exostosis, CTCAE 5.0

A disorder characterized by non-neoplastic overgrowth of bone.


Grade 3 Buttock Pain, CTCAE

Severe pain; limiting self care ADL


Muscle Weakness Upper Limb, CTCAE

A disorder characterized by a reduction in the strength of the upper limb muscles.


Grade 3 Myalgia, CTCAE

Severe pain; limiting self care ADL


Grade 3 Osteoporosis, CTCAE

Adult: Loss of height >=2 cm; hospitalization indicated; limiting self care ADL; Pediatric: Limiting self care ADL


Grade 1 Myalgia, CTCAE

Mild pain


Grade 4 Rhabdomyolysis, CTCAE

Life-threatening consequences; dialysis


Grade 2 Unequal Limb Length, CTCAE

Moderate length discrepancy 2-5 cm; shoe lift indicated; limiting instrumental ADL


Grade 2 Joint Range of Motion Decreased Lumbar Spine, CTCAE

Pain with range of motion (ROM) in lumbar spine; requires a reaching aid to pick up a very light object from the floor


Superficial Soft Tissue Fibrosis, CTCAE

A disorder characterized by fibrotic degeneration of the superficial soft tissues.


Grade 2 Flank Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 3 Neck Pain, CTCAE

Severe pain; limiting self care ADL


Grade 3 Head Soft Tissue Necrosis, CTCAE

Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)


Joint Range of Motion Decreased Lumbar Spine, CTCAE

A disorder characterized by a decrease in flexibility of a lumbar spine joint.


Grade 2 Soft Tissue Necrosis Lower Limb, CTCAE

Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Grade 1 Muscle Weakness Upper Limb, CTCAE

Symptomatic; perceived by patient but not evident on physical exam


Grade 3 Bone Pain, CTCAE

Severe pain; limiting self care ADL


Osteoporosis, CTCAE 5.0

A disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence.


Grade 1 Flank Pain, CTCAE

Mild pain


Grade 1 Joint Range of Motion Decreased Lumbar Spine, CTCAE

Stiffness; difficulty bending to the floor to pick up a very light object but able to do athletic activity


Grade 5 Rhabdomyolysis, CTCAE

Death


Grade 3 Pelvic Soft Tissue Necrosis, CTCAE


Grade 1 Scoliosis, CTCAE

<20 degrees; clinically undetectable


Grade 1 Neck Pain, CTCAE

Mild pain


Grade 3 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Fibrosis Deep Connective Tissue, CTCAE

A disorder characterized by fibrotic degeneration of the deep connective tissues.


Grade 3 Joint Range of Motion Decreased Lumbar Spine, CTCAE

<50% lumbar spine flexion; associated with symptoms of ankylosis or fused over multiple segments with no L-spine flexion (e.g., unable to reach to floor to pick up a very light object)


Grade 1 Chest Wall Pain, CTCAE

Mild pain


Grade 4 Osteonecrosis of Jaw, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Osteonecrosis, CTCAE

Severe symptoms; limiting self care ADL; elective operative intervention indicated


Lordosis, CTCAE

A disorder characterized by an abnormal increase in the curvature of the lumbar portion of the spine.


Grade 2 Myositis, CTCAE

Moderate pain associated with weakness; pain limiting instrumental ADL


Grade 2 Scoliosis, CTCAE

>20-45 degrees; visible by forward flexion; limiting instrumental ADL


Grade 3 Joint Effusion, CTCAE

Severe symptoms; limiting self care ADL; invasive intervention indicated


Grade 3 Arthritis, CTCAE

Severe pain associated with signs of inflammation, erythema, or joint swelling; irreversible joint damage; limiting self care ADL


Grade 2 Muscle Weakness Upper Limb, CTCAE

Symptomatic; evident on physical exam; limiting instrumental ADL


Grade 2 Avascular Necrosis, CTCAE

Symptomatic; limiting instrumental ADL


Grade 1 Generalized Muscle Weakness, CTCAE


Grade 4 Neck Soft Tissue Necrosis, CTCAE


Grade 1 Exostosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Buttock Pain, CTCAE

Mild pain


Grade 2 Pelvic Soft Tissue Necrosis, CTCAE


Grade 5 Superficial Soft Tissue Fibrosis, CTCAE

Death


Grade 1 Joint Range of Motion Decreased, CTCAE

<=25% loss of ROM (range of motion); decreased ROM limiting athletic activity


Grade 1 Osteoporosis, CTCAE

Adult: Radiologic evidence of osteoporosis or Bone Mineral Density (BMD) t-score -1 to -2.5 (osteopenia); Pediatric: Radiologic evidence of low BMD with z score of <= -2.0 and no history of significant fractures


Grade 1 Muscle Weakness Lower Limb, CTCAE

Symptomatic; perceived by patient but not evident on physical exam


Grade 1 Growth Suppression, CTCAE

Reduction in growth velocity by 10-29% ideally measured over the period of a year


Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE


Grade 4 Head Soft Tissue Necrosis, CTCAE


Grade 4 Superficial Soft Tissue Fibrosis, CTCAE

Generalized; associated with signs or symptoms of impaired breathing or feeding


Grade 3 Muscle Cramp, CTCAE

Severe pain; limiting self care ADL


Back Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the back region.


Grade 2 Soft Tissue Necrosis Upper Limb, CTCAE

Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Grade 5 Chest Wall Necrosis, CTCAE

Death


Musculoskeletal Deformity, CTCAE

A disorder characterized by a malformation of the musculoskeletal system.


Grade 2 Rhabdomyolysis, CTCAE

Non-urgent intervention indicated


Grade 2 Joint Range of Motion Decreased, CTCAE

>25-50% decrease in ROM; limiting instrumental ADL


Grade 3 Rhabdomyolysis, CTCAE

Symptomatic, urgent intervention indicated


Grade 5 Osteonecrosis, CTCAE

Death


Buttock Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the buttocks.


Grade 3 Joint Range of Motion Decreased, CTCAE

>50% decrease in ROM; limiting self care ADL


Grade 2 Muscle Cramp, CTCAE

Moderate pain; limiting instrumental ADL


Grade 1 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Soft Tissue Necrosis Upper Limb, CTCAE

A disorder characterized by a necrotic process occurring in the soft tissues of the upper extremity.


Grade 2 Superficial Soft Tissue Fibrosis, CTCAE

Moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL


Osteonecrosis of Jaw, CTCAE

A disorder characterized by a necrotic process occurring in the bone of the mandible.


Grade 1 Trismus, CTCAE

Decreased ROM (range of motion) without impaired eating


Grade 3 Myositis, CTCAE

Pain associated with severe weakness; limiting self care ADL


Grade 1 Muscle Cramp, CTCAE

Mild pain


Grade 1 Bone Pain, CTCAE

Mild pain


Grade 3 Flank Pain, CTCAE

Severe pain; limiting self care ADL


Grade 4 Pelvic Soft Tissue Necrosis, CTCAE

Life-threatening consequences; urgent intervention indicated


Flank Pain, CTCAE

A disorder characterized by a sensation of marked discomfort on the lateral side of the body in the region below the ribs and above the hip.


Growth Suppression, CTCAE

A disorder characterized by stature that is smaller than normal as expected for age.


Grade 5 Fibrosis Deep Connective Tissue, CTCAE

Death


Grade 5 Osteonecrosis of Jaw, CTCAE

Death


Grade 2 Generalized Muscle Weakness, CTCAE

Symptomatic; evident on physical exam; limiting instrumental ADL


Grade 1 Fibrosis Deep Connective Tissue, CTCAE

Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)


Unequal Limb Length, CTCAE

A disorder characterized by a discrepancy between the lengths of the lower or upper extremities.


Grade 5 Soft Tissue Necrosis Lower Limb, CTCAE

Death


Myalgia, CTCAE

A disorder characterized by marked discomfort sensation originating from a muscle or group of muscles.


Neck Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the neck area.


Grade 3 Growth Suppression, CTCAE

Reduction in growth velocity of >=50% ideally measured over the period of a year


Grade 2 Joint Range of Motion Decreased Cervical Spine, CTCAE

Rotation <60 degrees to right or left; <60 degrees of flexion


Grade 2 Kyphosis, CTCAE

Moderate accentuation; limiting instrumental ADL


Grade 3 Soft Tissue Necrosis Lower Limb, CTCAE

Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)


Grade 3 Muscle Weakness Trunk, CTCAE

Limiting self care ADL


Avascular Necrosis, CTCAE

A disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure.


Grade 5 Soft Tissue Necrosis Upper Limb, CTCAE

Death


Grade 1 Joint Effusion, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Osteonecrosis of Jaw, CTCAE

Severe symptoms; limiting self care ADL; elective operative intervention indicated


Grade 3 Abdominal Soft Tissue Necrosis, CTCAE


Grade 2 Back Pain, CTCAE

Moderate pain; limiting instrumental ADL


Pelvic Soft Tissue Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the soft tissues of the pelvis.


Pain In Extremity, CTCAE

A disorder characterized by a sensation of marked discomfort in the upper or lower extremities.


Grade 5 Avascular Necrosis, CTCAE

Death


Grade 2 Muscle Weakness Lower Limb, CTCAE


Grade 4 Avascular Necrosis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Abdominal Soft Tissue Necrosis, CTCAE

Death


Grade 4 Soft Tissue Necrosis Lower Limb, CTCAE


Chest Wall Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the chest wall.


Grade 2 Abdominal Soft Tissue Necrosis, CTCAE

Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Grade 3 Rotator Cuff Injury, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Muscle Weakness Trunk, CTCAE

A disorder characterized by a reduction in the strength of the trunk muscles.


Generalized Muscle Weakness, CTCAE

A disorder characterized by a reduction in the strength of muscles in multiple anatomic sites.


Grade 3 Back Pain, CTCAE

Severe pain; limiting self care ADL


Soft Tissue Necrosis Lower Limb, CTCAE

A disorder characterized by a necrotic process occurring in the soft tissues of the lower extremity.


Grade 4 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE


Grade 5 Neck Soft Tissue Necrosis, CTCAE

Death


Chest Wall Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the soft tissues of the chest wall including breast.


Grade 2 Rotator Cuff Injury, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL


Grade 3 Fibrosis Deep Connective Tissue, CTCAE

Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL


Muscle Weakness Lower Limb, CTCAE

A disorder characterized by a reduction in the strength of the lower limb muscles.


Grade 2 Growth Suppression, CTCAE

Reduction in growth velocity by 30-49% ideally measured over the period of a year or 0-49% reduction in growth from the baseline growth curve


Abdominal Soft Tissue Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the soft tissues of the abdominal wall.


Grade 1 Rhabdomyolysis, CTCAE

Asymptomatic, intervention not indicated; laboratory findings only


Grade 1 Lordosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Arthralgia, CTCAE

A disorder characterized by a sensation of marked discomfort in a joint.


Grade 2 Osteoporosis, CTCAE

Adult: BMD t-score < -2.5; loss of height <2 cm; therapy to improve BMD indicated; limiting instrumental ADL; Pediatric: Low BMD (z-score <= -2.0) and significant fracture history (defined as a long bone fracture of the lower extremity, vertebral compression, 2 or more long bone fractures of the upper extremities); therapy to improve BMD indicated


Grade 3 Generalized Muscle Weakness, CTCAE

Limiting self care ADL


Grade 3 Avascular Necrosis, CTCAE

Severe symptoms; limiting self care ADL; elective operative intervention indicated


Grade 4 Fibrosis Deep Connective Tissue, CTCAE

Generalized; associated with signs or symptoms of impaired breathing or feeding


Grade 2 Chest Wall Necrosis, CTCAE

Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Rhabdomyolysis, CTCAE

A disorder characterized by the breakdown of muscle tissue resulting in the release of muscle fiber contents into the bloodstream.


Grade 4 Abdominal Soft Tissue Necrosis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Muscle Weakness Trunk, CTCAE

Symptomatic; evident on physical exam; limiting instrumental ADL


Bone Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the bones.


Scoliosis, CTCAE

A disorder characterized by a malformed, lateral curvature of the spine.


Grade 1 Back Pain, CTCAE

Mild pain


Grade 3 Lordosis, CTCAE

Severe accentuation; operative intervention indicated; limiting self care ADL


Joint Range of Motion Decreased Cervical Spine, CTCAE

A disorder characterized by a decrease in flexibility of a cervical spine joint.


Grade 2 Osteonecrosis, CTCAE

Symptomatic; medical intervention indicated (e.g., analgesics or bisphosphonates); limiting instrumental ADL


Grade 3 Chest Wall Necrosis, CTCAE

Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)


Neck Soft Tissue Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the soft tissues of the neck.


Head Soft Tissue Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the soft tissues of the head.


Grade 1 Arthritis, CTCAE

Mild pain with inflammation, erythema, or joint swelling


Grade 5 Head Soft Tissue Necrosis, CTCAE

Death


Grade 2 Lordosis, CTCAE

Moderate accentuation; limiting instrumental ADL


Grade 1 Joint Range of Motion Decreased Cervical Spine, CTCAE

Mild restriction of rotation or flexion between 60-70 degrees


Grade 3 Musculoskeletal Deformity, CTCAE

Significant deformity, hypoplasia, or asymmetry, unable to be remediated by prosthesis or covered by clothing; limiting self care ADL


Grade 1 Superficial Soft Tissue Fibrosis, CTCAE

Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)


Grade 1 Arthralgia, CTCAE

Mild pain


Grade 2 Joint Effusion, CTCAE

Symptomatic; limiting instrumental ADL


Grade 2 Bone Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 5 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE

Death


Grade 5 Vaginal Hemorrhage, CTCAE

Death


Grade 2 Lip Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Moniliform hamartoma

A type of pilosebaceous hamartoma characterized by the development of a linear, flesh colored, fine papular eruption on the head, neck and upper chest after puberty.


Apocrine Sweat Gland Hamartoma

A hamartoma characterized by localized apocrine sweat gland malformation.


Recurrent Endometrial Undifferentiated Carcinoma

The reemergence of endometrial undifferentiated carcinoma after a period of remission.


Metastatic Endometrial Undifferentiated Carcinoma

Endometrial undifferentiated carcinoma that has spread from its original site of growth to another anatomic site.


Refractory Endometrial Undifferentiated Carcinoma

Endometrial undifferentiated carcinoma that is resistant to treatment.


Esophageal Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor that arises from the esophagus.  The majority are spindle cell tumors that exhibit high mitotic activity and affect the distal esophagus.


Grade 4 Retinopathy, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Grade 2 Wrist Fracture, CTCAE

Limiting instrumental ADL; outpatient operative intervention indicated


Grade 2 Neonatal Fever, AE

An adverse event in a newborn characterized by fever, minor change in baseline age-appropriate behavior; minor changes in care (e.g. environmental settings, symptomatic treatment).


Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Oral cavity cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVB Lip and Oral Cavity Cancer AJCC v6 and v7

Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Lip and oral cavity cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVB Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7


Stage IVB Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7


Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Lip and oral cavity cancer with very advanced local disease. Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVB Oral Cavity Cancer AJCC v6 and v7


Stage IVB Lip Cancer AJCC v6 and v7

Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Lip cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Grade 1 Oropharyngeal Pain, CTCAE

Mild pain


Grade 2 Premature Menopause, CTCAE

Present


Grade 5 Pharynx Obstruction and Stenosis, CTCAE


Pathologic Stage IB Cutaneous Melanoma AJCC v8

Stage IB includes: T2a, N0, M0. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Vein of Galen Malformations

An arteriovenous malformation in the vein of Galen that is located at the base of the brain. The malformation may result in developmental delays, hydrocephalus, seizures, and congestive heart failure.


Grade 1 Tracheal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Dextro-Transposition of the Great Vessels with Ventricular Septal Defect

A congenital heart defect in which there is an abnormal arrangement of any of the primary blood vessels of the heart in conjunction with a pathologic opening between the cardiac ventricles.


Grade 2 Retinopathy of Prematurity, AE

An adverse event in a newborn characterized by type 2 prethreshold retinopathy of prematurity (ROP) (zone 1 International Classification of Retinopathy of Prematurity (ICROP) stage 1 or 2 without plus disease; zone 2 ICROP stage 3 without plus disease); requiring more frequent ophthalmic monitoring.


Grade 2 Intestinal Stoma Obstruction, CTCAE

Self-limited; intervention not indicated


dipeptide

Any molecule that contains two amino-acid residues connected by peptide linkages.


Grade 4 Retinal Detachment, CTCAE

Macula-off rhegmatogenous retinal detachment


Retinal Detachment, CTCAE 5.0

A disorder characterized by the separation of the inner retina layers from the underlying pigment epithelium.


Grade 3 Retinal Detachment, CTCAE

Macular sparing rhegmatogenous detachment


Stage II Low-CSD Melanoma AJCC v7

Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0).  T2b: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, with ulceration.  T3a: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, without ulceration.  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  T4b: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Ed.)


Stage II Cutaneous Melanoma AJCC v6 and v7

Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0).  T2b: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, with ulceration.  T3a: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, without ulceration.  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  T4b: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


Stage II Lentigo Maligna Melanoma AJCC v6 and v7


Stage IIC Cutaneous Melanoma AJCC v6 and v7

Stage IIC includes: T4b, N0, M0.  T4b: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


Stage IIB Cutaneous Melanoma AJCC v6 and v7

Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0).  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


Stage IIA Cutaneous Melanoma AJCC v6 and v7

Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, with ulceration.  T3a: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


Grade 4 Thrombosis or Embolism Vascular Access Related, CTCAE


Grade 5 Non-Malignant Pleural Effusion, CTCAE


Grade 5 Dental-Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Retroperitoneal Hemorrhage, CTCAE

Death


Atypical Vascular Proliferation

Benign vascular proliferations following external radiation. The lesions present in adults, predominantly in elderly women following radiotherapy for breast carcinoma. They arise from the radiated skin and are papules, small vesicles, or erythematous ecchymotic plaques with prominent telangiectasias. Identical lesions can occur after radiation for cervical carcinoma, endometrial carcinoma, ovarian carcinoma, Hodgkin lymphoma, and melanoma. There is an increased risk for subsequent development of angiosarcoma.


Atypical Vascular Lesion of Breast

Benign vascular proliferations following external radiation for breast carcinoma. The lesions arise from the radiated skin and are papules, small vesicles, or erythematous ecchymotic plaques with prominent telangiectasias. There is an increased risk for subsequent development of angiosarcoma.


Grade 4 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


inorganic peroxide

Compounds of structure ROOR' in which R and R' are inorganic groups.


maghemite

An iron oxide mineral with formula Fe2O3 formed by weathering of spinels containing iron(II) such as magnetite or titanomagnetite, or through dehydration and transformation of some iron oxyhydroxide minerals. A brown or yellow pigment found in various sediments and soils.


hematite nanoparticle

An iron oxide nanoparticle composed of hematite (Fe2O3).


maghemite nanoparticle

A superparamagnetic iron oxide nanoparticle consisting of maghemite, Fe2O3.


silicon dioxide nanoparticle

A nanoparticle consisting of silicon dioxide.


Bladder squamous cell carcinoma recurrent

The reemergence of bladder squamous cell carcinoma after a period of remission.


Recurrent Non-Muscle Invasive Bladder Carcinoma

The reemergence of non-muscle invasive bladder carcinoma after a period of remission.


Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma

The reemergence of non-muscle invasive bladder urothelial carcinoma after a period of remission.


Recurrent Muscle Invasive Bladder Urothelial Carcinoma

The reemergence of muscle invasive bladder urothelial carcinoma after a period of remission.


Recurrent Bladder Small Cell Neuroendocrine Carcinoma

The reemergence of bladder small cell neuroendocrine carcinoma after a period of remission.


Bladder adenocarcinoma recurrent

A recurrence of adenocarcinoma of the bladder after a period of remission.


Urothelial carcinoma bladder recurrent

The reemergence of bladder urothelial carcinoma after a period of remission.


Grade 3 Arachnoiditis, CTCAE

Severe symptoms; limiting self care ADL


PERSISTENT MULLERIAN DUCT SYNDROME, TYPE II

Persistent Mullerian duct syndrome due to resistance to anti-Mullerian hormone (AMH), resulting from mutations in the AMH receptor (AMHR) gene.


Stage IV Paranasal Sinus Cancer AJCC v7

Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Sinonasal Adenocarcinoma, Intestinal-Type with Papillary Pattern

An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a papillary growth pattern.


Stage IVA Lip and Oral Cavity Cancer AJCC v8

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a (lip): Tumor invades through cortical bone or involves the inferior alveolar nerve, floor of mouth, or skin of face (i.e., chin or nose).  T4a (oral cavity): Tumor invades adjacent structures only (e.g., through cortical bone of the mandible or maxilla, or involves the maxillary sinus or skin of face). Note: Superficial erosion of bone/tooth socket (alone) by a gingival primary is not sufficient to classify a tumor as T4. T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI. T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE (-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension, ENE(-). M0: No distant metastasis. (AJCC 8th Ed.)


Metastatic Salivary Gland Squamous Cell Carcinoma

Salivary gland squamous cell carcinoma that has spread from the original site of growth to another anatomic site.


Recurrent Sinonasal Squamous Cell Carcinoma

The reemergence of nasal cavity and paranasal sinus squamous cell carcinoma after a period of remission.


Adenoid cystic carcinoma of the oral cavity stage II

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Locally Advanced Oral Cavity Squamous Cell Carcinoma

Oral cavity squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IVC Lip Cancer AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Lip and Oral Cavity Cancer by AJCC v6 and v7 Stage

A term that refers to the staging of lip and oral cavity carcinoma according to the American Joint Committee on Cancer, 6th and 7th editions.


Cutaneous Squamous Cell Carcinoma of the Head and Neck by AJCC v8 Stage

A term that refers to the staging of cutaneous squamous cell carcinoma of the head and neck according to the American Joint Committee on Cancer, 8th edition.


Lip basal cell carcinoma

A basal cell carcinoma arising from the lip.


Unresectable Head and Neck Carcinoma

Carcinoma that arises from the head and neck region and is not amenable to surgical resection.


Stage IVB Nasal Cavity and Paranasal Sinus Cancer AJCC v7

Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Locally Recurrent Head and Neck Squamous Cell Carcinoma

The reemergence of head and neck squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Sinonasal Spindle Cell Squamous Cell Carcinoma

A poorly differentiated squamous cell carcinoma arising from the sinonasal tract. It is characterized by the presence of malignant cells with spindle cell features.


Lower Alveolar Ridge Squamous Cell Carcinoma

Squamous cell carcinoma arising from the lower alveolar ridge.


Stage I Nasal Cavity Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1:Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Salivary Gland Secretory Carcinoma

A rare, low-grade carcinoma of the salivary gland with favorable clinical outcome.  It usually arises from the parotid gland and less often from the minor salivary glands.  It shares the same histopathologic features and molecular characteristics (ETV6 gene rearrangement) with secretory breast carcinoma.


Sinonasal Large Cell Neuroendocrine Carcinoma

A large cell neuroendocrine carcinoma that arises from the nasal cavity and paranasal sinuses.


Hard Palate Adenoid Cystic Carcinoma

An adenoid cystic carcinoma arising from the minor salivary glands in the hard palate.


An adenocarcinoma that arises from the nasal cavity and paranasal sinuses.  Histologically it resembles intestinal carcinoma or adenoma.  It is associated with lengthy occupational exposure to dust.


Ameloblastic Carcinoma Derived From Odontogenic Cyst

A rare, aggressive malignant tumor that originates from an odontogenic cyst in the maxillomandibular region.  It combines the histologic features of an ameloblastoma and carcinoma.


Adenocarcinomas that arise from the nasal cavity and paranasal sinuses and do not resemble salivary gland adenocarcinomas. This category includes intestinal-type and non-intestinal type adenocarcinomas.


Recurrent Lip and Oral Cavity Carcinoma

The reemergence of lip and/or oral cavity carcinoma after a period of remission.


Metastatic Salivary Gland Carcinoma

A salivary gland carcinoma that has metastasized to another anatomic site.


Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor 4 cm or larger in greatest dimension or minor bone erosion or perineural invasion or deep invasion. Deep invasion is defined as invasion beyond the subcutaneous fat or larger than 6 mm; perineural invasion for T3 classification is defined as tumor cells within the nerve sheath of a nerve lying deeper than the dermis or measuring 0.1 mm or larger in caliber, or presenting with clinical or radiographic involvement of named nerves without skull base invasion or transgression. T1: Tumor smaller than 2 cm in greatest dimension.  T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


Carcinoma of base of tongue

A carcinoma that arises from the base of the tongue.  Representative examples include squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.


Stage I Sinonasal Squamous Cell Carcinoma AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IV Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. T4a (oral cavity): Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face). T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension. N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension. N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Head and Neck Merkel Cell Carcinoma

An extremely rare Merkel cell carcinoma affecting the head and neck lymph nodes. It may represent metastasis from a regressed dermal primary. (WHO 2017)


Primary Intraosseous Squamous Cell Carcinoma Derived From Keratocystic Odontogenic Tumor

A rare, well-differentiated, keratinizing squamous cell carcinoma that arises centrally from the jaw and is associated with the presence of a keratocystic odontogenic tumor.


Head and Neck Large Cell Neuroendocrine Carcinoma

A large cell neuroendocrine carcinoma that arises from the head and neck.


Upper Alveolar Ridge Squamous Cell Carcinoma

Squamous cell carcinoma arising from the upper alveolar ridge.


Advanced Head and Neck Carcinoma

A head and neck carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Posterior Tongue Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the base of the tongue.  It usually presents as a painful ulcerated lesion.


Sinonasal Human Papillomavirus-Related Carcinoma with Adenoid Cystic-Like Features

A distinctive HPV-related non-keratinizing squamous cell carcinoma of the sinonasal tract arising most frequently from the maxillary sinus or nasal cavity. Most patients present with nasal obstruction and/or epistaxis. It is characterized by the presence of basaloid cell proliferations separated by collagenous fibrous bands. The basaloid cells align around microcystic spaces.


Stage 0 Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Anterior Tongue Adenoid Cystic Carcinoma

An adenoid cystic carcinoma arising from the minor salivary glands in the anterior tongue.


Unresectable Oral Cavity Squamous Cell Carcinoma

Oral cavity squamous cell carcinoma that is not amenable to surgical resection.


Squamous cell carcinoma of head and neck metastatic

A head and neck squamous cell carcinoma which has spread from the original site of growth to another anatomic site.


Stage IV Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: (oral cavity) Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal NUT Carcinoma

A highly aggressive, poorly differentiated carcinoma that arises from the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene.


Sclerosing Odontogenic Carcinoma

A rare, low-grade primary intraosseous carcinoma of the jaws, with bland cytology, markedly sclerotic stroma, and aggressive infiltration. It is characterized by single-file thin cords, nests, and strands of epithelium in a densely sclerotic stroma. Cytologically, individual epithelial cells are bland, with infrequent mitoses. Their cytoplasm may show vacuolation or partial clearing. There is no squamous differentiation. Despite the benign appearance, there is invasion of skeletal muscle, and perineural infiltration is characteristic. (WHO 2017)


Sinonasal Poorly Differentiated Carcinoma

A poorly differentiated carcinoma that arises from the nasal cavity and/or paranasal sinuses.


Stage IVA Oral Cavity Cancer AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Adenoid cystic carcinoma of the oral cavity stage III

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Metastatic Oral Cavity Squamous Cell Carcinoma

A squamous cell carcinoma of the oral cavity which has spread from the original site of growth to another anatomic site.


Sinonasal Cancer by AJCC v8 Stage

A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 8th edition.


Metastatic Oral Cavity Carcinoma

A carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


Ghost Cell Odontogenic Carcinoma

A carcinoma usually arising from the maxilla and less often the mandible.  Symptoms include swelling and paresthesia.  It is characterized by the presence of rounded islands of malignant epithelial cells in a fibrous stroma and the benign features of calcifying cystic odontogenic tumor.  The clinical course varies from slow growing and locally invasive to rapidly growing and highly aggressive with metastases.


Minor Salivary Gland Small Cell Neuroendocrine Carcinoma

An infrequent small cell carcinoma that arises from a minor salivary gland. It is characterized by the presence of neuroendocrine differentiation and a high number of mitotic figures.


Recurrent Salivary Gland Cancer

The reemergence of salivary gland carcinoma after a period of remission.


Stage IVC Nasal Cavity and Paranasal Sinus Cancer AJCC v7

Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Metastatic Lip Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the lip and has metastasized to another anatomic site.


Advanced Salivary Gland Carcinoma

Salivary gland carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Paranasal Sinus Carcinoma

Paranasal sinus carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IVA Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7


Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage 0 Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Locally Advanced Head and Neck Squamous Cell Carcinoma

A head and neck squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Paranasal Sinus Keratinizing Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the paranasal sinuses and is characterized by prominent production of keratin.


Platinum-Resistant Head and Neck Carcinoma

Head and neck carcinoma that is resistant to platinum therapy.


Stage III Nasal Cavity Cancer AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Tumor restricted to any one subsite, with or without bony invasion.  T2: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Metastatic Lip and Oral Cavity Carcinoma

A carcinoma that arises from the lip and/or oral cavity and has metastasized to another anatomic site.


Recurrent Lip and Oral Cavity Squamous Cell Carcinoma

The reemergence of lip and oral cavity squamous cell carcinoma after a period of remission.


Low Grade Salivary Gland Carcinoma

A salivary gland carcinoma with low grade histopathologic features.  It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, and low grade salivary gland mucoepidermoid carcinoma.  It usually follows a non-aggressive clinical course.


Stage IVB Lip and Oral Cavity Cancer AJCC v8

Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases the internal carotid artery. N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE (-); or in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. (AJCC 8th Ed.)


Head and Neck Keratinizing Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the head and neck region and is characterized by prominent production of keratin.


Unresectable Salivary Gland Carcinoma

Salivary gland carcinoma that is not amenable to surgical resection.


Locally Advanced Lip and Oral Cavity Carcinoma

Lip and oral cavity carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IVC Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IVC Sinonasal Squamous Cell Carcinoma AJCC v7

Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Metastatic Sinonasal Carcinoma

Sinonasal carcinoma that has spread from its original site of growth to another anatomic site.


Low Grade Salivary Gland Mucoepidermoid Carcinoma

A salivary gland mucoepidermoid carcinoma with low grade histopathologic features.  It usually follows a non-aggressive clinical course.


Recurrent Lip Basal Cell Carcinoma

Reemergence of basal cell carcinoma of the lip after a period of remission.


Stage IV Sinonasal Squamous Cell Carcinoma AJCC v7

Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Stage II Oral Cavity Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Metastatic Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


Stage II Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage II Sinonasal Squamous Cell Carcinoma AJCC v6 and v7

Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th ed.)


Minor Salivary Gland Acinic Cell Carcinoma

An adenocarcinoma with serous acinar cell differentiation that arises from the minor salivary glands.


Stage II Nasal Cavity Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0.  T2: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Head and Neck Heterotopia-Associated Carcinoma

A head and neck carcinoma arising from heterotopic tissue elements (i.e. histologically normal tissue of a particular type that is present at an abnormal anatomical site). (WHO 2017)


Stage 0 Lip and Oral Cavity Cancer AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Ameloblastic Carcinoma-Secondary Type (Dedifferentiated), Intraosseous

A very rare ameloblastic carcinoma that originates from a pre-existing intraosseous benign ameloblastoma.


Head and neck cancer metastatic

A carcinoma that arises from the head and neck and has spread from the original site of growth to another anatomic site.


Locally Advanced Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that has spread to nearby tissues or lymph nodes.


Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck

The reemergence of cutaneous squamous cell carcinoma of the head and neck after a period of remission.


Stage I Lip and Oral Cavity Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Adenocarcinoma

Adenocarcinomas that arises from the sinonasal tract. This category includes salivary-type and non-salivary type adenocarcinomas. The latter includes intestinal-type and non-intestinal-type adenocarcinomas.


Stage IVA Sinonasal Squamous Cell Carcinoma AJCC v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Keratinizing Primary Intraosseous Squamous Cell Carcinoma-Solid Type

A squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, keratin production, infiltration of the marrow spaces, and osseous resorption.


Posterior Tongue Adenoid Cystic Carcinoma

An adenoid cystic carcinoma arising from the minor salivary glands in the base of the tongue.


Stage IVC Oral Cavity Cancer AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


adenocarcinoma of oral cavity

An adenocarcinoma that arises from the oral cavity.


Sinonasal Adenocarcinoma, Salivary-Type

Adenocarcinomas that arise from the seromucinous glands and surface epithelium of the nasal cavity and paranasal sinuses. These adenocarcinomas morphologically resemble the adenocarcinomas that arise from the major and minor salivary glands.


Stage IVA Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Hard Palate Mucoepidermoid Carcinoma

A mucoepidermoid carcinoma arising from the minor salivary glands in the hard palate.


Stage II Lip and Oral Cavity Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


Locally Advanced Salivary Gland Carcinoma

A salivary gland carcinoma that has spread to nearby tissues or lymph nodes.


Adult Salivary Gland Carcinoma

A carcinoma of the salivary gland that occurs during adulthood.


Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v6

Stage IV maxillary sinus cancer: Stage IV is divided into stages IVA, IVB, and IVC.  Stage IVA: cancer has spread to either one lymph node on the same side of the neck as the cancer and the lymph node is larger than 3 centimeters but smaller than 6 centimeters; or, cancer has spread to more than one lymph node anywhere in the neck, and all are 6 centimeters or smaller; cancer is also found in any of the following areas: the maxillary sinus, bones around the maxillary sinus, tissues under the skin, the eye socket, the base of the skull, and the ethmoid sinuses or cancer is found in one or more lymph nodes in the neck, none larger than 6 centimeters, and in any of the following areas: the front of the eye, the skin of the cheek, the base of the skull, behind the jaw, the bone between the eyes, and the sphenoid or frontal sinuses. Stage IVB: cancer has spread to either: one or more lymph nodes larger than 6 centimeters; or the back of the eye, the brain, the base and middle parts of the skull, nerves in the head, and/or the upper part of the throat behind the nose; cancer may also be found in one or more lymph nodes. Stage IVC: cancer has spread to other parts of the body.  Stage IV nasal cavity and ethmoid sinus cancer: Stage IV is divided into stages IVA, IVB, and IVC.  Stage IVA: cancer has spread to either one lymph node on the same side of the neck as the cancer and the lymph node is larger than 3 centimeters but smaller than 6 centimeters; or, cancer has spread to more than one lymph node anywhere in the neck, and all are 6 centimeters or smaller; cancer is also found in any of the following places: the nasal cavity or ethmoid sinus., the eye socket, the maxillary sinus, the roof of the mouth, and the bone between the eyes or cancer is found in one or more lymph nodes in the neck, and the lymph nodes are 6 centimeters or smaller; cancer is also found in any of the following areas: the front of the eye, the skin of the nose or cheek, front parts of the skull, the base of the skull, and the sphenoid or frontal sinuses.  Stage IVB: cancer is found in any of the following areas: the back of the eye, the brain, the middle parts of the skull, nerves in the head the upper part of the throat behind the nose and the base of the skull.  Cancer may also be found in one or more lymph nodes or cancer is found in a lymph node that is larger than 6 centimeters.  Stage IVC: cancer has spread to other parts of the body (from PDQ).


Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip and oral cavity cancer with moderately advanced local disease. Lip: Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. Oral cavity: Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Lip and Oral Cavity Cancer AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Unresectable Sinonasal Squamous Cell Carcinoma

Sinonasal squamous cell carcinoma that is not amenable to surgical resection.


anaplastic carcinoma of salivary gland

A salivary gland carcinoma characterized by the presence of undifferentiated, anaplastic malignant epithelial cells.


Sinonasal Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from the nasal cavity and paranasal sinuses.


Unresectable Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that is not amenable to surgical resection.


Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that has spread from the original site of growth to another anatomic site.


Stage I Paranasal Sinus Cancer

Stage I includes: T1, N0, M0.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Cancer by AJCC v6 Stage

A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 6th edition.


Tongue Carcinoma

A malignant tumor arising from the epithelium that covers the tongue.  The vast majority of tongue carcinomas are moderately or poorly differentiated squamous cell carcinomas.


Metastatic Oral Cavity Mucoepidermoid Carcinoma

A mucoepidermoid carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


Carcinoma in situ of middle ear

An intraepithelial carcinoma of the middle ear without evidence of invasion.


adenoid cystic carcinoma of floor of mouth

An adenoid cystic carcinoma of the oral cavity that arises from the floor of the mouth.


Salivary Gland Poorly Differentiated Carcinoma

A high-grade carcinoma that arises from the salivary glands. This category includes large and small cell types with or without neuroendocrine differentiation.


Low Grade Papillary Schneiderian Carcinoma

A rare sinonasal carcinoma characterized by the presence of a papillary architecture and bland morphological features similar to the Schneiderian papilloma, a pushing pattern of stromal invasion, and an increased risk of local recurrence.


Adenoid cystic carcinoma of the oral cavity recurrent

The reemergence of adenoid cystic carcinoma in the oral cavity after a period of remission.


Stage IV Oral Cavity Cancer AJCC v6 and v7

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: (oral cavity) Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Recurrent Oral Cavity Carcinoma

The reemergence of carcinoma in the oral cavity after a period of remission.


Recurrent Paranasal Sinus Squamous Cell Carcinoma

The reemergence of paranasal sinus squamous cell carcinoma after a period of remission.


Stage I Nasal Cavity and Paranasal Sinus Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Lip and Oral Cavity Cancer AJCC v6 and v7

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  T4a (oral cavity): Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Localized Head and Neck Carcinoma

Head and neck carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


Sinonasal Adenocarcinoma, Intestinal-Type with Mixed Pattern

An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a mixture of growth patterns.


Mucoepidermoid carcinoma of the oral cavity recurrent

The reemergence of mucoepidermoid carcinoma in the oral cavity after a period of remission.


Intermediate Grade Salivary Gland Mucoepidermoid Carcinoma

A salivary gland mucoepidermoid carcinoma with intermediate grade histopathologic features.


Squamous cell carcinoma of the oral cavity stage IV


Primary Intraosseous Squamous Cell Carcinoma-Solid Type

A non-keratinizing or keratinizing squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, infiltration of the marrow spaces, and osseous resorption.


Recurrent Head and Neck Carcinoma

The reemergence of carcinoma in the head and neck region after a period of remission.


Cutaneous Squamous Cell Carcinoma of the Head and Neck

A squamous cell carcinoma that arises from the skin of the head and neck.


Stage I Lip Carcinoma

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Salivary Gland Oncocytic Carcinoma

A high grade adenocarcinoma that arises from the salivary glands. The vast majority of cases have been described in the parotid gland.  It is characterized by the presence of malignant oncocytes.  It recurs and metastasizes to regional or distant anatomic sites.


Stage IVA Paranasal Sinus Cancer AJCC v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses.  Ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Adenoid cystic carcinoma of the tongue

An adenoid cystic carcinoma arising from the minor salivary glands in the tongue.


Metastatic Salivary Gland Adenocarcinoma

Salivary gland adenocarcinoma that has spread from its original site of growth to another anatomic site.


Refractory Head and Neck Carcinoma

A head and neck carcinoma that does not respond to treatment.


Recurrent Sinonasal Carcinoma

The reemergence of nasal cavity or paranasal sinus carcinoma after a period of remission.


Head and Neck NUT Carcinoma

A highly aggressive, poorly differentiated carcinoma that arises from the head and neck. Most cases are in the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene.


Minor Salivary Gland Squamous Cell Carcinoma

A squamous cell carcinoma that affects the minor salivary glands.


Stage IVA Lip and Oral Cavity Cancer AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip and oral cavity cancer with moderately advanced local disease.  Lip: Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  Oral cavity: Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


High Grade Salivary Gland Mucoepidermoid Carcinoma

A salivary gland mucoepidermoid carcinoma with high grade histopathologic features.  It usually follows an aggressive clinical course.


Stage IVB Sinonasal Squamous Cell Carcinoma AJCC v7

Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Adenocarcinoma of salivary gland

An adenocarcinoma arising from the salivary gland.  It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland oncocytic carcinoma, salivary gland mucinous adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, salivary gland cystadenocarcinoma, salivary gland basal cell adenocarcinoma, salivary gland acinic cell carcinoma, salivary duct carcinoma, and salivary gland adenocarcinoma not otherwise specified.


Recurrent Minor Salivary Gland Adenocarcinoma

The reemergence of minor salivary gland adenocarcinoma after a period of remission.


Stage IV Nasal Cavity Cancer

Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Stage IVB Paranasal Sinus Cancer AJCC v7


Stage II Paranasal Sinus Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage III Nasal Cavity and Paranasal Sinus Cancer AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Squamous cell carcinoma of the oral cavity stage II

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage III Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Small Cell Neuroendocrine Carcinoma

A very rare small cell neuroendocrine carcinoma that arises from the nose and paranasal sinuses.


Squamous cell carcinoma of the oral cavity stage III


ASPH-Positive Head and Neck Squamous Cell Carcinoma

A head and neck squamous cell carcinoma in which the malignant cells are positive for ASPH gene.


Sinonasal Keratinizing Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the mucosal epithelium of the nasal cavity or the paranasal sinuses and is characterized by prominent production of keratin.


Stage IVC Nasal Cavity and Paranasal Sinus Cancer AJCC v8

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Stage II Nasal Cavity and Paranasal Sinus Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)