Borderline Broad Ligament Serous Tumor

A rare non-invasive tumor that arises from the broad ligament. It is characterized by the presence of serous epithelial cell proliferation and cytological atypia.


Lymphosarcoma of spleen

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An antiquated term that refers to a non-Hodgkin lymphoma composed of small and medium sized lymphocytes affecting the spleen.


Grade 3 Myocardial Infarction, CTCAE

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Severe symptoms; cardiac enzymes abnormal; hemodynamically stable; ECG changes consistent with infarction


Grade 4 Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic Digestive System Neuroendocrine Neoplasm

A neuroendocrine neoplasm that arises from any part of the digestive system and has metastasized to another anatomic site.


Ache

A dull persistent (usually moderately intense) pain.


Thrombotic Disorder

A disorder in which there is pathological development of blood clots within the cardiovascular system.


Primary cutaneous acral CD8 positive T-cell lymphoma

A primary cutaneous T-cell lymphoproliferative disorder that presents as an acral (peripheral) lesion. It is composed of CD8-positive neoplastic T-lymphocytes. It is usually localized to a single site and has an indolent clinical course. Local or more extensive recurrences have been described in a minority of patients.


Vaginal Hemorrhage, CTCAE

A disorder characterized by bleeding from the vagina.


Grade 3 Joint Intra-Operative Injury, CTCAE


Grade 5 Urinary Tract Infection, CTCAE

Death


Grade 2 Ileum Stricture or Stenosis, CTCAE


Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Secondary Glioblastoma

A glioblastoma arising from a lower grade astrocytoma.


Grade 3 Cholesterol High, CTCAE

>400-500 mg/dL; >10.34-12.92 mmol/L


Grade 4 Leukemia Secondary To Oncology Chemotherapy, CTCAE

Present


A lymphoproliferative disorder that occurs in a patient with immunodeficiency.


Recurrent Malignant Glioma

The reemergence of malignant glioma after a period of remission.


Grade 2 Outer Ear Pinna Intra-Operative Injury, CTCAE


Grade 1 Skin Intra-Operative Injury, CTCAE


AIDS-Related Hodgkin Lymphoma

Hodgkin lymphoma secondary to AIDS. An increased incidence of Hodgkin lymphomas has been observed in HIV positive patients. Most cases are morphologically classified as lymphocyte depleted or mixed cellularity Hodgkin lymphomas.


Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Solar Radiation-Related Malignant Neoplasm

A malignant neoplasm arising in an anatomic site exposed to solar radiation.


Grade 2 Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Cranial Nerve VI Neuropathy, CTCAE


Grade 3 Pleura Intra-Operative Injury, CTCAE


Grade 3 Carotid Artery Intra-Operative Injury, CTCAE


Grade 1 Mediastinum Intra-Operative Injury, CTCAE


Basal cell hyperplasia

A pathologic hyperplastic process characterized by the proliferation of the cells of the epithelial layer that resemble the basal cells of the lower part of the epidermis.


PSA 50 Percent or Greater than Nadir

A finding indicating that the blood concentration of prostate specific antigen in a subject's sample has increased by 50 percent or more over the lowest value recorded for a sample from that subject.


Childhood Nervous System Neoplasm

A neoplasm that affects the nervous system during childhood.


Multilocular Thymic Cyst

A multicystic lesion that arises from the epithelial component of the thymus gland.  It is usually associated with the presence of lymphoid follicles and degenerative changes.  Although its etiology is unknown, it has been described in patients with HIV infection and in patients with nodular sclerosis Hodgkin lymphoma affecting the thymus gland.


Extra-adrenal paraganglioma, malignant

An extra-adrenal paraganglioma that metastasizes to regional or distant anatomic sites.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


Adult Myofibroma

A rare myofibroma that occurs in adults.


Grade 3 Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Cholecystitis, CTCAE

Symptomatic; medical intervention indicated


Grade 5 Larynx Obstruction and Stenosis, CTCAE


Grade 4 Thoracic Duct Intra-Operative Injury, CTCAE


Otitis Externa, CTCAE

A disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage.


Subcutaneous edema

Presence of edema in subcutaneous connective tissue.


Grade 2 Ileal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Unresectable Abdominal Neuroendocrine Neoplasm

An abdominal neuroendocrine neoplasm that is not amenable to surgical resection.


Grade 4 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


BCOR-CCNB3 sarcoma

A group of rare primitive round cell sarcomas characterized by the presence of BCOR-CCNB3 fusion gene.


Grade 2 Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


AIDS-Related Lymphoma by Working Formulation


Lugano Classification Stage II Bulky Hodgkin Lymphoma AJCC v8

Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Grade 3 Reduction in Growth Velocity, CTCAE


Non-Neoplastic Urethra Disorder

A non-neoplastic disorder affecting the urethra.


Recurrent Spindle Cell Sarcoma

The reemergence of spindle cell sarcoma after a period of remission.


Unresectable Gallbladder Adenocarcinoma

Adenocarcinoma that arises from the gallbladder and is not amenable to surgical resection.


Grade 1 Periventricular Leukomalacia, AE

An adverse event in a newborn characterized by transient periventricular echodensities persisting greater than seven days and resolving completely.


Grade 3 Esophagus Intra-Operative Injury, CTCAE


Ankle Fracture, CTCAE

A finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot.


Recurrent Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

The reemergence of acute myeloid leukemia with recurrent genetic abnormalities after a period of remission.


Usual Prostate Adenocarcinoma with Neuroendocrine Differentiation

Acinar adenocarcinoma of the prostate gland characterized by the presence of scattered neuroendocrine cells by immunohistochemistry.


Grade 5 Colonic Perforation, CTCAE

Death


Grade 2 Disseminated Intravascular Coagulation, CTCAE

Laboratory findings with no bleeding


Grade 3 Ear Pain, CTCAE

Severe pain; limiting self care ADL


Benign neoplasm of broad ligament

A neoplasm that arises from the broad ligament and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Mature Plasmacytoid Dendritic Cell Proliferation Associated with Myeloid Neoplasm

A clonal proliferation of plasmacytoid dendritic cells in patients with defined myeloid neoplasms. It is characterized by neoplastic proliferations of mature cells with plasmacytoid morphology in the skin, bone marrow, and very rarely, lymph nodes. Patients are predominantly older males.


Serous Endometrial Intraepithelial Carcinoma

A precursor of endometrial serous adenocarcinoma characterized by the replacement of the normal endometrial cells by malignant glandular cells that resemble the malignant cells of invasive serous adenocarcinoma. The endometrial neoplastic process is non-invasive. It may coexist with invasive endometrial adenocarcinoma or can be associated with metastases outside the uterus, in the absence of invasive endometrial carcinoma.


Grade 5 Neck Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Arrhythmia-Induced Cardiomyopathy

A reversible cardiomyopathy presumed to result from the presence of arrhythmias, including the tachycardia-induced cardiomyopathy (T-CM), atrial fibrillation-induced cardiomyopathy (AF-CM), and premature ventricular contraction-induced cardiomyopathy (PVC-CM).


Grade 1 Salivary Gland Fistula, CTCAE

Asymptomatic


Stage IIA Prostate Cancer AJCC v7

Stage IIA includes: (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X). T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  (AJCC 7th ed.)


Grade 3 Electrocardiogram QT Corrected Interval Prolonged, CTCAE

Average QTc >= 501 ms; >60 ms change from baseline


Blue rubber bleb nevus syndrome

A hemangioma present at birth.  It is characterized by the presence of rubbery skin lesions.


Injury of prostate

Trauma to the prostate.


Refractory Digestive System Neuroendocrine Neoplasm

A digestive system neuroendocrine neoplasm that is resistant to treatment.


Corneal Infection, CTCAE

A disorder characterized by an infectious process involving the cornea.


Grade 3 Small Intestine Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Gastrointestinal Radiation Injury

Radiation injury of the gastrointestinal system.


Grade 1 Uterine Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 3 Other Constitutional Symptoms, CTCAE


Severe Sepsis

Clinical syndrome defined by the presence of both infection and a systemic inflammatory response that progresses to multi-organ failure.


Thoracoceloschisis

A congenital fissure of both the thoracic and abdominal walls.


Grade 2 Depression, CTCAE

Moderate depressive symptoms; limiting instrumental ADL


In situ mantle cell neoplasia

A neoplastic lymphoid process characterized by the presence of cyclin D1 positive lymphoid cells, typically in the inner mantle zones of lymphoid tissue follicles, in cases that do not suggest the diagnosis of a mantle cell lymphoma. It is often found incidentally and has a low rate of progression.


Bronchial Fistula, CTCAE

A disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site.


Clinical Stage IV Esophageal Adenocarcinoma AJCC v8

Stage IV includes: IVA: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Testicular Disorder, CTCAE

A disorder characterized by abnormal function or appearance of the testis.


Small cell carcinoma, fusiform cell

A neuroendocrine carcinoma composed of malignant fusiform small cells.


Systemic Hydroa Vacciniforme Lymphoproliferative Disorder

Hydroa vacciniforme lymphoproliferative disorder characterized by severe clinical course and associated with fever, lymph node involvement, and involvement of internal organs by EBV-positive T-cells and NK-cells. It usually affects Asian and Latin American individuals.


Recurrent Endocervical Adenocarcinoma, Usual-Type

The reemergence of endocervical adenocarcinoma, usual-type after a period of remission.


Grade 3 Urinary Incontinence, CTCAE

Intervention indicated (e.g., clamp, collagen injections); operative intervention indicated; limiting self care ADL


Stage III Renal Pelvis and Ureter Cancer AJCC v8

Stage III includes: T3, N0, M0. T3: For renal pelvis only: Tumor invades beyond muscularis into peripelvic fat or into the renal parenchyma. For ureter only: Tumor invades beyond muscularis into periureteric fat. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Peritoneal Cavity Intra-Operative Injury, CTCAE


Bile Duct Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the bile duct.


Grade 4 Electrocardiogram QT Corrected Interval Prolonged, CTCAE

Torsade de pointes; polymorphic ventricular tachycardia; signs/symptoms of serious arrhythmia


Grade 5 Jejunal Perforation, CTCAE

Death


Grade 3 Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Enterocolitis, CTCAE

Life-threatening consequences; urgent intervention indicated


mucinous cystic neoplasm with moderate dysplasia

A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of moderate dysplasia.  The neoplastic columnar mucin-producing epithelial cells form papillary projections or crypt-like invaginations. There is cellular pseudostratification and mitotic activity present.


Hindgut Neuroendocrine Tumor G1

A neuroendocrine tumor grade 1 that arises from the sigmoid colon, descending colon, or rectum.


Stage IA Osteosarcoma AJCC v7

Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 5 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Chronic Leukemia

The reemergence of chronic leukemia after a period of remission.


Gallbladder Fistula, CTCAE

A disorder characterized by an abnormal communication between the gallbladder and another organ or anatomic site.


Grade 5 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Filiform Serrated Adenoma

A traditional serrated adenoma characterized by the presence of prominent villous projections of the neoplastic epithelium.


Grade 3 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Acute Panmyelosis with Myelofibrosis

The reemergence of acute panmyelosis with myelofibrosis after a period of remission.


Grade 4 Gastrointestinal Stoma Intra-Operative Injury, CTCAE


Grade 4 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Mild epithelial dysplasia

A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. It is characterized by the presence of mild epithelial dysplasia.


Grade 3 Alanine Aminotransferase Increased, CTCAE

>5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


Non-Neoplastic Cardiovascular Disorder

A non-neoplastic disorder that affects the heart and/or vessels.  Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema.


Locally Advanced Bladder Urothelial Carcinoma

A bladder urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Intestinal Stoma Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 3 Duodenal Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Grade 5 Infantile Apnea, AE

An apneic adverse event in a newborn which results in death.


Grade 3 Fatigue, CTCAE

Fatigue not relieved by rest, limiting self care ADL


dyskeratosis congenita

A rare genetic disorder characterized by nail dystrophy, reticulated skin pigmentation especially on the neck and chest, and oral leukoplakia.  In about half the cases mutations in the TERT, TERC, DKC1, or TINF2 genes are identified.  Patients are at an increased risk of developing bone marrow failure, myelodysplastic syndrome, leukemia, or cancer, especially in the head and neck region.


Chronic acquired lymphedema

A condition that is caused by trauma to the lymph system, which disrupts the normal flow of lymph fluid. This is most often due to surgery that requires lymph node removal or a large amount of lymph tissue. This disruption is especially apparent if the lymph nodes under the arm and arm and around the breast are compromised due to breast cancer surgery, diagnostic dissection, mastectomy, or radiation.


Grade 5 Neonatal Spontaneous Intestinal Perforation, AE

A spontaneous intestinal perforation (SIP) adverse event in a newborn which results in death.


Grade 3 Central Nervous System Necrosis, CTCAE

Severe symptoms; medical intervention indicated


Grade 5 Otitis Externa, CTCAE

Death


Grade 2 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Prolapse of Urostomy, CTCAE

Life-threatening consequences; urgent intervention indicated


Abdominal Infection, CTCAE

A disorder characterized by an infectious process involving the abdominal cavity.


Chest Pain Along Right Middle Sternal Border

The location of the chest pain is along the right middle border of the sternum.


Acute Myeloid Leukemia with Gene Mutations

A group of acute myeloid leukemias characterized by the presence of gene mutations that are associated with myelodysplasia.


Stage IV Prostate Cancer AJCC v6

Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, Any N, M1) (Any G).  T4: Tumor is fixed or invades adjacent structures other than seminal vesicles: bladder neck, external sphincter, rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 6th ed.)


General Disorders and Administration Site Conditions, CTCAE


Testicular Sertoli Cell Tumor, Lipid Rich Variant

A testicular Sertoli cell tumor in which the neoplastic cells have clear and vacuolated cytoplasm due to accumulation of intracytoplasmic lipids.


Grade 2 Dyspnea, CTCAE

Shortness of breath with minimal exertion; limiting instrumental ADL


Endometrial Dedifferentiated Carcinoma

A carcinoma that arises from the endometrium and is characterized by the presence of an undifferentiated carcinomatous component and a second component of either FIGO grade 1 or 2 endometrioid carcinoma.


Adult Type Granulosa Cell Tumor

A low-grade malignant sex cord-stromal tumor occurring in the ovary and rarely in the testis. It is composed of granulosa cells in an often fibrothecomatous stroma. The neoplastic cells may form various patterns including the microfollicular, which is characterized by the presence of Call-Exner bodies, macrofollicular, insular, trabecular, and diffuse pattern. In females, it affects middle aged to post-menopausal women. Signs and symptoms include abdominal mass, hemoperitoneum, and ascites. Estrogenic and rarely androgenic manifestations may be present. The vast majority of cases present as stage I tumors; however, all tumors have a potential for aggressive clinical course. In males, it is reported in the age range of 16-76 years and the average age at presentation is 44 years. A minority of patients have gynecomastia. Metastases have been reported in a minority of patients.


Grade 2 Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


Grade 2 Tooth Development Disorder, CTCAE

Impairment correctable with oral surgery


Stage IA2 Cervical Cancer FIGO 2009

Cervical carcinoma measuring more than 3 mm and not more than 5 mm in depth. (FIGO 2009)


Grade 3 Lip Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Cranial Nerve X Intra-Operative Injury, CTCAE


Grade 5 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


A1 Hydronephrosis

Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of 4 to less than 7 mm at less than 28 weeks, 2) to less than10 mm at greater than or equal to 28 weeks, and 3) may have central calyceal dilation. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Grade 2 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Cecal Hemorrhage, CTCAE

Death


Grade 2 Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Childhood Benign Genitourinary System Neoplasm

A childhood neoplasm that arises from any part of the genitourinary system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 4 Pulmonary Valve Disease, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)


Grade 4 Tracheal Stenosis, CTCAE

Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Invasive Lipid-Rich Urothelial Carcinoma

Invasive urothelial carcinoma characterized by the presence of lipid laden tumor cells.


Grade 2 Hepatic Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 4 Portal Vein Intra-Operative Injury, CTCAE


Fourth Degree Perineal Laceration

Injury to perineum involving anal sphincter complex and internal anal sphincter and anal epithelium. (reVITALize)


Sickle Cell-SS Disease

A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles.


Steroid-induced myopathy

A non-neoplastic disorder affecting the skeletal muscles. It is caused by damage to muscle fibers either by excessive intake of corticosteroids (steroid treatment) or high levels of endogenous corticosteroids due to hormonal abnormalities. Patients usually present with weakness mainly in the proximal muscles of the upper and lower extremities and the neck flexors.


Grade 3 Upper Extremity Intra-Operative Injury, CTCAE


Grade 1 Left Ventricular Systolic Dysfunction, CTCAE


Grade 3 Small Intestine Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated; limiting self care ADL


Neonatal Early-Onset Sepsis

An infectious disorder of newborn infants that is characterized by a systemic inflammatory response within 72 hours of life and is most commonly caused by bacteria.


Grade 1 Gastrointestinal Stoma Leak, CTCAE


Grade 3 Diarrhea, CTCAE

Increase of >=7 stools per day over baseline; hospitalization indicated; severe increase in ostomy output compared to baseline; limiting self care ADL


Rheumatic aortic valve disease

A disorder of the aortic valve secondary to rheumatic fever.


Grade 1 Hypoxic Ischemic Encephalopathy, AE

An adverse event in a newborn clinically classified as perinatal asphyxia, but not resulting in encephalopathy.


Refractory Cervical Carcinoma

Cervical carcinoma that is resistant to treatment.


Grade 5 Rectal Obstruction, CTCAE

Death


Intrahepatic Bile Duct Biliary Intraepithelial Neoplasia

A neoplastic, non-invasive lesion that affects the intrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Grade 3 Intra-Abdominal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Idiopathic 46,XY Differences of Sex Development

Conditions affecting individuals whose karyotype is 46,XY that is characterized by atypical development of the internal or external sex structures, or the gonads, and in whom no genetic, environmental, or biochemical causation can be established.


Stage IIB Ampulla of Vater Cancer AJCC v7

Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades the duodenal wall.  T3: Tumor invades the pancreas.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Islet Glucagon Cell Hyperplasia

Hyperplasia of the alpha cells of the pancreas.


Grade 3 Cardiac Troponin T Increased, CTCAE

Levels consistent with myocardial infarction as defined by the manufacturer


Malignant neoplasm of urethra local

A malignant neoplasm of the urethra that has not spread to other regions.


Unresectable Pancreatic Neuroendocrine Carcinoma

Pancreatic neuroendocrine carcinoma that is not amenable to surgical resection.


Mucosal Melanoma of the Urinary System

A malignant melanocytic neoplasm that arises from a mucosal site of the urinary system.


Exogenous Obesity

Obesity caused by caloric intake greater than caloric expenditures.


Biventricular congestive heart failure

Heart failure due to dysfunction of both the left and right ventricles.


Recurrent Extracranial Malignant Solid Neoplasm

The reemergence of an extracranial malignant solid neoplasm after a period of remission.


Proctitis, CTCAE

A disorder characterized by inflammation of the rectum.


Aleukemic Acute Lymphoblastic Leukemia Cutis

Aleukemic leukemia cutis where the skin in infiltrated by lymphoblasts.


Grade 3 Cognitive Disturbance, CTCAE

Severe cognitive disability; significant impairment of work/school/life performance


HPV16 Infection

An infection caused by human papillomavirus 16. HPV16 infection is associated with a risk for cervical cancer.


Grade 5 Neonatal Rash, AE

A rash adverse event in a newborn which results in death.


Hemangioma of conjunctiva

A hemangioma that arises from the conjunctiva.


Neonatal Spontaneous Intestinal Perforation, AE

An adverse event in a newborn characterized by a perforation in the gastrointestinal tract of a newborn with no demonstrable cause.


Grade 2 Vein NOS Intra-Operative Injury, CTCAE


Grade 4 Intraoperative Neurological Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Esophageal Varices Hemorrhage, CTCAE 5.0

A disorder characterized by bleeding from esophageal varices.


Grade 1 Confusion, CTCAE

Mild disorientation


Exertional Fatigue

Prolonged, extreme exhaustion after physical or mental effort or stress.


Grade 1 Feminization Acquired, CTCAE

Mild symptoms; intervention not indicated


Refractory Gallbladder Carcinoma

Gallbladder carcinoma that is resistant to treatment.


Ileal Fistula

An abnormal communication between the ileum and another organ or cavity.


Vulvar Non-Neoplastic Disorder

A non-neoplastic disorder that affects the vulva. Representative examples include infection and fibroepithelial polyp.


Recurrent Laryngeal Nerve Palsy, CTCAE

A disorder characterized by paralysis of the recurrent laryngeal nerve.


Grade 4 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


External hydrocephalus

Abnormal increase of cerebrospinal fluid in the subdural space of the brain.


Grade 2 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 3 Gastric Fistula, CTCAE

Invasive intervention indicated


A Hodgkin lymphoma that develops in patients who are immunosuppressed with methotrexate.


Advanced Extrapulmonary Neuroendocrine Carcinoma

Extrapulmonary neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adult Diffuse Mixed Cell Lymphoma

A B-or T-cell non-Hodgkin lymphoma composed of a mixed-sized lymphocytic population occurring in adults.


Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Esophageal Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus.  It is characterized by the presence of malignant large cells.


Grade 3 Tendon Reflex Decreased, CTCAE

Absence of all reflexes


Grade 2 Hypotension, CTCAE

Non-urgent medical intervention indicated


Grade 1 Edema Limbs, CTCAE

5-10% inter-limb discrepancy in volume or circumference at point of greatest visible difference; swelling or obscuration of anatomic architecture on close inspection


Flu Like Symptoms, CTCAE

A disorder characterized by a group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite and dry cough.


Recurrent Subsequent Malignant Neoplasm

The reemergence of a malignant neoplasm other than the original one, after a period of remission.


Grade 4 Neuroendocrine ADH Secretion Abnormality, CTCAE


Stage IVA Esophageal Squamous Cell Carcinoma


Grade 1 Obstruction Gastric, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Muscle Weakness Left-Sided, CTCAE

A disorder characterized by a reduction in the strength of the muscles on the left side of the body.


Grade 5 Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Eye Melanocytoma

A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve or the uvea.


Grade 3 Intraoperative Urinary Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


tubular adenoma of gallbladder

An adenoma that arises from the gallbladder.  It is characterized by the presence of a tubular growth pattern.


End Organ Damage from Diabetes

Irreparable damage to multiple organs/systems which is the result of chronic complications of diabetes.  The affected organs/systems include the cardiovascular system, kidneys, eyes, nervous system, joints and feet.


Grade 4 Dental and Teeth and Peridontal Pain, CTCAE


Grade 5 Neonatal Culture Negative Sepsis, AE

A culture negative neonatal sepsis adverse event in a newborn which results in death.


Human Papillomavirus-Related Cervical Carcinoma

A carcinoma that arises from the cervix and is caused by human papillomavirus infection.


Stage IV Uterine Corpus Cancer AJCC v6

Stage IV includes: IVA: (T4, Any N, M0); IVB: (Any T, Any N, M1).  T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M1: Distant metastasis (includes metastasis to abdominal lymph nodes other than para-aortic, and/or inguinal lymph nodes: excludes metastasis to vagina, pelvic serosa, or adnexa). (AJCC 6th ed.)


Grade 4 Pharyngeal Mucositis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Sinus Tachycardia, CTCAE

Urgent medical intervention indicated


Oligometastatic Gastric Adenocarcinoma

Gastric adenocarcinoma that has metastasized to a limited number of sites.


Grade 3 Cystitis Noninfective, CTCAE

Gross hematuria; transfusion, IV medications, or hospitalization indicated; elective invasive intervention indicated


Grade 3 Irritability in Children Less Than 3 Years of Age, CTCAE


Grade 3 Cushingoid, CTCAE

Severe symptoms, medical intervention or hospitalization indicated


Stage IB Vulvar Carcinoma AJCC v6

Stage IB includes: T1b, N0, M0.  T1ab Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Appendix Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to appendiceal NETs (carcinoid tumors) (NET G1 and G2, and rare well-differentiated G3). High-grade neuroendocrine carcinomas (NEC), goblet cell carcinoids, mixed adenocarcinomas, and adenocarcinomas of the appendix are not staged using this staging system. (from AJCC 8th Ed.)


Breast Neuroendocrine Tumor G1

A well-differentiated, low grade neuroendocrine neoplasm arising from the breast.


Grade 3 Cough, CTCAE

Severe symptoms; limiting self care ADL


Grade 1 Neonatal Respiratory Insufficiency, AE

An adverse event in a newborn characterized by clinical evidence of mildly increased respiratory distress (e.g. increased work of breathing) without significant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); no change in baseline functioning; no care changes required.


Grade 4 Myocarditis, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support)


MGMT-Methylated Glioblastoma

A glioblastoma characterized by the presence of DNA methylation in the promoter region of the MGMT gene. It is associated with improved survival.


Stage III Skin Cancer

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th Ed.)


Mental Retardation, X-linked 21/34

An X-linked recessive condition caused by mutation(s) in the IL1RAPL1 gene, encoding interleukin-1 receptor accessory protein-like 1. It is characterized by intellectual disability ranging from moderate mental retardation to high-functioning autism.


Endometrial Endometrioid Adenocarcinoma with a Poorly Differentiated Carcinomatous Component

A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with poorly differentiated carcinoma cells.


Grade 3 Glomerular Filtration Rate, CTCAE


Grade 2 Hypohidrosis, CTCAE

Symptomatic; limiting instrumental ADL


Grade 5 Glucose Intolerance, CTCAE

Death


Thyroid Stimulating Hormone Increased, CTCAE

A disorder characterized by an increase in thyroid stimulating hormone.


Grade 4 Salivary Duct Inflammation, CTCAE


Stage I Gallbladder Cancer AJCC v6

Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor invades lamina propria or muscle layer.  T1a: Tumor invades lamina propria.  T1b: Tumor invades muscle layer.  N0: No regional metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IV Childhood Large Cell Lymphoma

Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)


Recurrent Fallopian Tube Transitional Cell Carcinoma

The reemergence of fallopian tube transitional cell carcinoma after a period of remission.


Adverse Event Associated with the Vascular System


Neonatal Respiratory Distress Syndrome, AE

An adverse event in a newborn characterized by progressive alveolar atelectasis from birth due to an abnormality of synthesis, function or metabolism of surfactant, characterized by respiratory failure and an abnormal chest radiograph showing diffuse reticulogranular densities and air bronchograms.


Grade 1 Flashing Lights and Floaters in Vision, CTCAE


Grade 2 Trochlear Nerve Disorder, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 2 Weight Loss, CTCAE

10-<20% from baseline; nutritional support indicated


Foreign body embolism

Occlusion of a lumen by a foreign object.


Stage IIIB Cervical Cancer AJCC v6 and v7

Stage IIIB includes: (T3b, Any N, M0); (T1-3, N1, M0).  T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Malignant melanoma, regressing

A skin lesion characterized by the disappearance of the melanoma cells from the primary melanoma site. The disappearance of the malignant cells is associated with fibroplasia of the papillary dermis. According to some authors, complete regression of the primary melanoma may occur in 4-8% of patients.


Grade 5 Supraventricular Arrhythmia NOS, CTCAE


Grade 3 Pleuritic Pain, CTCAE

Severe pain; limiting self care ADL


Lentigo simplex

The most common form of the skin disorder lentigo, characterized by a single or multiple benign, pigmented macules of unknown etiology that are present at birth or develop in early childhood.


Increased Concomitant Drug Half Life

Increased period of time required for the concentration or amount of a concomitant drug in the body to be reduced to exactly one-half of a given concentration or amount.


Grade 4 Breast Intra-Operative Injury, CTCAE


Hodgkin's disease nodular sclerosis stage II subdiaphragmatic


Grade 3 Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage 0 Cutaneous Melanoma AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Melanoma in situ.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


Calcifying Odontogenic Cyst

A simple odontogenic cyst lined by ameloblastoma-like epithelium, which contains focal accumulations of ghost cells. (WHO 2017)


Testicular Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the testis.


Grade 1 Peripheral Motor Nerve NOS Intra-Operative Injury, CTCAE


Refractory Myeloid Neoplasm

A myeloid neoplasm that does not respond to treatment.


Stage IV Bladder Cancer AJCC v6

Stage IV includes the following: T4b, N0, M0; Any T, N1, M0; Any T, N2 M0; Any T, N3 M0; Any T, Any N, M1.  T4b: Tumor invades the pelvic wall, abdominal wall.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis.  (AJCC 6th Ed.)


Grade 4 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intestinal nematode infection

An infection in the gastrointestinal tract by a nematode.


Grade 1 Other Hemorrhage and Bleeding, CTCAE


Stage IIA Anal Cancer AJCC v8

Stage IIA includes: T2, N0, M0. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Treatment related secondary malignancy

The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself.


Grade 2 Vaginal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 1 Productive Cough, CTCAE

Occasional/minimal production of sputum with cough


Anal Extramucosal (Perianal) Adenocarcinoma

An anal adenocarcinoma arising from the lining of an anorectal fistulous tract or the anal glands.  The overlying anal mucosa does not show evidence of neoplastic changes.  It usually presents as a submucosal tumor.


Grade 1 Oral Cavity Fistula, CTCAE

Asymptomatic


Grade 3 Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Trigeminal Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Childhood Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-MLL

An acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A occurring in children.


Stage IV Childhood Hodgkin Lymphoma by Toronto Guidelines v2

Diffuse or disseminated (multifocal) involvement of one or more extra-lymphatic organs with or without associated lymph node involvement or isolated (non-contiguous) extra-lymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s) or any involvement of liver, bone marrow, lungs (except by direct extension from another site) or CSF. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Locally Advanced Neuroendocrine Tumor

A neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Tracheal Mucositis

An inflammatory process affecting the mucous membrane of the trachea.


Lugano Classification Stage II Bulky Adult Hodgkin Lymphoma AJCC v8

Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Orbital Contusion

Bruising of the skin and soft tissue surrounding the eye.


Acute Myeloid Leukemia with a Variant MECOM Rearrangement

A term referring to acute myeloid leukemias with rearrangement of the MECOM gene with various genes other than the GATA2 gene.


Cystic Periventricular Leukomalacia

Necrosis and softening of the white matter around the ventricles in the brain associated with cystic changes.


Hamartoma of Mature Cardiac Myocytes

A non-malignant, focal growth in the heart, composed of unencapsulated nodules of enlarged, hypertrophic, mature cardiac myocytes with a variable amount of collagen and fat.


Prosoposchisis

A congenital anatomic defect characterised by a facial cleft that extends from the mouth to the orbit of the eye.


Grade 4 Colon or Cecum or Appendix Necrosis, CTCAE


Grade 2 Genitourinary Stoma Stricture or Stenosis, CTCAE


Advanced Malignant Female Reproductive System Neoplasm

A malignant female reproductive system neoplasm that has spread extensively from its original site of growth to other anatomic sites or is no longer responding to treatment.


Grade 2 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 5 Intraoperative Hepatobiliary Injury, CTCAE

Death


Nose Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Sporadic Retinoblastoma

A retinoblastoma that occurs in a patient without a family history of the disease.


Grade 3 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Anorexia, CTCAE

Loss of appetite without alteration in eating habits


Intraoperative Splenic Injury, CTCAE

A finding of damage to the spleen during a surgical procedure.


Malignant Non-Hodgkin's Lymphoma, Diffuse, Lymphocytic, Poorly Differentiated


Grade 5 Spasticity, CTCAE

Death


Intra-Operative Injury by Anatomic Descriptor, CTCAE


Recurrent Acute Leukemia

The reemergence of acute leukemia after a period of remission.


Locally Advanced Angiosarcoma

An angiosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Intracystic papillary neoplasm with low grade intraepithelial neoplasia

An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of mild epithelial atypia.


Grade 5 Visceral Arterial Ischemia, CTCAE

Death


Grade 2 Periventricular Leukomalacia, AE

An adverse event in a newborn characterized by transient periventricular echodensities evolving in to small localized fronto-parietal cysts or persistent diffuse echodensities.


Stage I Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

Tumor is limited to the kidney and completely excised. Renal capsule intact, not penetrated by tumor. No tumor invasion of veins or lymphatics of renal sinus. No nodal or hematogenous metastases. No prior biopsy. Negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 5 Vasculitis, CTCAE

Death


Grade 4 Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


Recurrent Myeloid Neoplasm

The reemergence of a myeloid neoplasm after a period of remission.


Pansclerotic Morphea

A rare, aggressive form of morphea characterized by sclerosis of the dermis, fascia, and muscle over large parts of the body, resulting in contractures and immobility.


Endocrine Therapy-Induced Alopecia

Alopecia caused by treatment with endocrine therapy agents.


Grade 5 Myelodysplastic Syndrome, CTCAE

Death


Death NOS, CTCAE

Death that cannot be attributed to a CTCAE term associated with Grade 5.


Transplant-Related Skin Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the skin in a patient with a history of organ transplantation.


Grade 2 Fallopian Tube Intra-Operative Injury, CTCAE


Radiating Chest Pain Along Right Midclavicular Line

The location of the radiating chest pain is along the right midclavicular line.


Female Non-Neoplastic Reproductive System Disorder

A non-neoplastic disorder that affects the female reproductive system. Representative examples include endometriosis, pelvic inflammatory disease, and endometritis.


Neonatal Late-Onset Sepsis

An infectious disorder of newborn infants that is characterized by a systemic inflammatory response beyond 72 hours of life and is most commonly caused by bacteria.


Grade 3 Cranial Nerve I Intra-Operative Injury, CTCAE


Recurrent Pancreatic Cystadenocarcinoma

The reemergence of pancreatic cystadenocarcinoma after a period of remission.


lipoma of bone

A benign neoplasm which is composed of adipocytes and arises from the surface of the bone or the medullary cavity.


Grade 5 Neonatal Convulsion, AE

An adverse event in a newborn characterized by death related to suspected seizures.


Extrapulmonary Neuroendocrine Carcinoma

A small or large cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


Prostate Myeloid Sarcoma

Myeloid sarcoma that affects the prostate gland.  It may present in association with or as a site of relapse of acute myeloid leukemia.  Cases of myeloid sarcoma of the prostate gland preceding acute myeloid leukemia have also been reported.


Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm

Blastic plasmacytoid dendritic cell neoplasm that is resistant to treatment.


Grade 5 Otitis External Ear Non Infectious, CTCAE


Hot Flashes, CTCAE

A disorder characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling.


Neonatal Epileptic Seizure, AE

An adverse event in a newborn characterized by an electroencephalogram (EEG) confirmed paroxysmal surge of electrical activity in the brain that may result in physical or behavioral changes.


Grade 3 Dizziness, CTCAE

Severe unsteadiness or sensation of movement; limiting self care ADL


Grade 2 Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Locally Advanced Gastric Carcinoma

A gastric carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Vulvar Melanocytic Neoplasm

A neoplasm that originates from melanocytes and arises from the vulva. This category includes congenital and acquired melanocytic nevus, blue nevus, dysplastic melanocytic nevus, atypical melanocytic nevus, genital type, and melanoma.


Cocaine dependence, continuous

Physical or psychological dependence on the drug cocaine which is associated with a pattern of continuous use.


Grade 1 Chest Pain - Cardiac, CTCAE

Mild pain


Prolonged Intubation After Pulmonary Resection, CTCAE


Grade 1 Portal Vein Intra-Operative Injury, CTCAE


Recurrent Adult Hodgkin Lymphoma

The reemergence of Hodgkin lymphoma in adulthood after a period of remission.


Classical Poroma

A benign neoplasm occurring in the intraepidermal portion of the sweat gland duct.


Spermatic Cord Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures).


Environment-Related Malignant Neoplasm

Cancers caused by exposure to carcinogens in the general environment


Moist Desquamation

A skin reaction characterized by sloughing of the epidermis and serous exudate.


Incidental Gallbladder Carcinoma

Gallbladder carcinoma that is discovered incidental to gallbladder surgery for another indication.


Grade 5 Leukoencephalopathy, CTCAE

Death


Penile Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the penis.


Grade 3 Cecum or Appendix Hemorrhage, CTCAE


Sciatic Nerve Intra-Operative Injury, CTCAE


Grade 1 Tumor Pain, CTCAE

Mild pain


Advanced Esophageal Carcinoma

Esophageal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Gastritis, CTCAE

Symptomatic; altered GI function; medical intervention indicated


Stage II Prostate Cancer AJCC v8

Stage II includes: IIA: (cT1a-c, cT2a, N0, M0, PSA equal or more than 10 and less than 20, Grade Group 1); (cT2b-c, N0, M0, PSA less than 20, Grade Group 1); IIB: T1-2, N0, M0, PSA less than 20, Grade Group 2; IIC: (T1-2, N0, M0, PSA less than 20, Grade Group 3); (T1-2, N0, M0, PSA less than 20, Grade Group 4). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. cT2b: Prostate cancer in which the tumor involves more than one-half of one side but not both sides. cT2c: Prostate cancer in which the tumor involves both sides. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


Childhood Retinoblastoma by Toronto Guidelines v2 Stage, Tier 1

A term that refers to the staging of childhood retinoblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Grade 3 Urinary Tract Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 3 Periorbital Edema, CTCAE

Edema associated with visual disturbance; increased intraocular pressure, glaucoma or retinal hemorrhage; optic neuritis; diuretics indicated; operative intervention indicated


Colitis, CTCAE

A disorder characterized by inflammation of the colon.


Childhood Liver Neoplasm

A benign or malignant neoplasm that affects the liver and occurs during childhood.


Grade 2 Dry Mouth, CTCAE

Moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min


Grade 4 Retina Intra-Operative Injury, CTCAE


Physical Examination Finding

The result of an evaluation of the body and its functions using visual inspection, palpation, percussion, or auscultation that is performed to determine the presence, absence, or degree of a condition.


Radiating Pain

A sensation of discomfort or distress that spreads from one anatomic location to another.


Grade 3 Personality Change, CTCAE

Severe personality change; hospitalization not indicated


Grade 1 Vertigo, CTCAE

Mild symptoms


Metastatic Bladder Large Cell Neuroendocrine Carcinoma

Bladder large cell neuroendocrine carcinoma that has spread to another anatomical site.


Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other

A rare type of primary cutaneous diffuse large B-cell lymphoma that does not belong in the group of primary cutaneous diffuse large B-cell lymphomas, leg type, or the group of primary cutaneous follicle center lymphomas.  It includes subtypes/entities of diffuse large B-cell lymphoma (e.g. intravascular large B-cell lymphoma, plasmablastic lymphoma, T-cell/histiocyte rich lymphoma) that can involve the skin as the primary anatomic site.  Such cases, unlike their nodal counterparts, usually have an excellent prognosis.


Grade 1 Insomnia, CTCAE

Mild difficulty falling asleep, staying asleep or waking up early


Grade 5 Ileum Stricture or Stenosis, CTCAE


Grade 2 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Surgical and Medical Procedures - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Fatigue, CTCAE

Fatigue relieved by rest


Metastatic ocular melanoma

Ocular melanoma that has spread from its original site of growth to another anatomic site.


Grade 1 Bronchial Stricture, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Hiccups, CTCAE

A disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm.


Grade 5 Vein Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Ventricular Tachycardia, CTCAE

Symptomatic, urgent intervention indicated


Grade 4 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Bruising in the Absence of Grade 3 or Grade 4 Thrombocytopenia, CTCAE


Grade 5 Intra-Abdominal Hemorrhage, CTCAE

Death


Grade 3 Pelvis Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Flashing Lights and Floaters in Vision, CTCAE


Cortical Cataract Grade 4

A stage of cortical cataract characterized by greater than 90% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Grade 2 Olfactory Nerve Disorder, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 2 Jejunal Perforation, CTCAE

Invasive intervention not indicated


Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8

Stage IIA includes: T1, N1, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Urethra Stricture or Stenosis, CTCAE


Low Grade Biliary Intraepithelial Neoplasia

Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial dysplasia.


Grade 3 Pharyngitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 4 Salivary Gland Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gallbladder Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Encephalopathy, CTCAE 5.0

A disorder characterized by a pathologic process involving the brain.


H-type congenital tracheoesophageal fistula

Congenital tracheoesophageal fistula without esophageal atresia.


Testicular Typical Seminoma

A testicular seminoma characterized by the presence of uniform round germ cells with glycogen-rich cytoplasm and large nuclei, and a lymphocytic infiltrate.


Grade 4 Laryngeal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., tracheotomy or intubation)


Grade 3 Cecal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 Salivary Gland Intra-Operative Injury, CTCAE


Non-Neoplastic Connective and Soft Tissue Disorder

A non-neoplastic disorder that affects the connective and soft tissue.


Grade 3 Extraocular Muscle Paresis, CTCAE

Bilateral paresis or unilateral paresis causing double vision in peripheral gaze, but not in central gaze


Peritoneal Pain

Painful sensation in the peritoneum.


Dental Caries, CTCAE

A disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous.


Neonatal Hypertension, AE

An adverse event in a newborn characterized by abnormally high blood pressure.


Grade 4 Hematuria, CTCAE

Life-threatening consequences; urgent invasive intervention indicated


Grade 2 Vestibular Disorder, CTCAE

Symptomatic; limiting instrumental ADL


Neoplasm by Morphology

A classification system grouping neoplasms according to their cellular characteristics.


Hypercalcemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood.


Grade 5 Laryngeal Hemorrhage, CTCAE

Death


Grade 2 Gastrointestinal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 4 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Small Bowel Perforation NOS, CTCAE


Edema Cerebral, CTCAE

A disorder characterized by swelling due to an excessive accumulation of fluid in the brain.


Grade 2 Scleral Necrosis and Melt, CTCAE


Grade 2 Dyspareunia, CTCAE

Moderate discomfort or pain associated with vaginal penetration; discomfort or pain partially relieved with use of vaginal lubricants or estrogen


Bladder Melanoma

A rare melanoma that arises from the bladder mucosa.


Grade 5 Central Nervous System Hemorrhage, CTCAE


Testosterone Deficiency, CTCAE

A disorder characterized by low testosterone.


Extranodal Lymphoma

A non-Hodgkin or Hodgkin lymphoma that arises from an anatomic site other than a lymph node.


Renal Radiation Injury

Radiation injury of the kidney.


Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Visceral Arterial Ischemia, CTCAE

A disorder characterized by a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery.


Non-Neoplastic Bladder Disorder

A non-neoplastic disorder that affects the urinary bladder. Representative examples include cystitis, cystolithiasis, and urinary bladder rupture.


Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Ampulla of Vater Intestinal-Type Adenocarcinoma

An invasive adenocarcinoma arising from the ampulla of Vater.  Morphologically, it is characterized by the presence of intestinal-type malignant epithelial cells.


Refractory T/NK-Cell Lymphoproliferative Disorder

T/NK-cell lymphoproliferative disorder that is resistant to treatment.


Acute Myeloid Leukemia with STAT3-RARA

Acute myeloid leukemia with variant RARA rearrangement and expression of STAT3-RARA fusion protein.


Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Diffuse hyperplasia

Hyperplasia characterized by the presence of a diffuse cellular infiltrate.


Grade 2 Voice Changes and Dysarthria, CTCAE


Chronic Cancer Pain

Chronic pain that results from cancer and/or its treatment. The mechanism for chronic cancer pain may be  inflammatory, neuropathic, ischemic, and/or mechanical in nature.


Stage IIIB Appendix Carcinoma AJCC v8

Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Floaters, CTCAE

Limiting self care ADL


carcinoma of urinary tract

A carcinoma that arises from the organs that comprise the urinary tract. This category includes renal pelvis carcinoma, ureter carcinoma, bladder carcinoma, urethral carcinoma, urothelial carcinoma, adenocarcinoma of the urinary tract, clear cell adenocarcinoma of the urinary tract, diverticular carcinoma of the urinary tract, endometrioid adenocarcinoma of the urinary tract, and squamous cell carcinoma of the urinary tract.


Grade 4 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Squamous cell carcinoma, microinvasive

A squamous cell carcinoma with minimal stromal invasion.


Childhood Retinoblastoma by Toronto Guidelines v2 Stage, Tier 2

A term that refers to the staging of childhood retinoblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage III includes: (T2, N1, M0); (T3, N0-1, M0); (T4a, N0-1, M0). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IIIA includes: T0-2, N1, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Duodenal Perforation, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Vagina Intra-Operative Injury, CTCAE


Lower Extremity Intra-Operative Injury, CTCAE


Grade 3 Dry Eye, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Grade 5 Small Intestinal Obstruction, CTCAE

Death


Grade 5 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cervical Cancer by FIGO Stage 2018

A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2018.


Scalp Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the skin covering the top and the back of the head.


Grade 5 Small Bowel Perforation NOS, CTCAE


Grade 5 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


AIDS-Related Malignant Anal Neoplasm

A malignant neoplasm arising from the anus and occurring in HIV-positive patients.  Representative examples include squamous cell carcinoma and non-Hodgkin lymphoma.  Homosexual HIV-positive men have an increased risk of developing such malignancies in comparison to the general male population.


Testicular Hemorrhage, CTCAE

A disorder characterized by bleeding from the testis.


Hyperthyroidism, CTCAE

A disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose.


Grade 5 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Hypertension, CTCAE

Adult: Systolic BP 120-139 mm Hg or diastolic BP 80-89 mm Hg; Pediatric: Systolic/diastolic BP >90th percentile but< 95th percentile; Adolescent: BP >= 120/80 even if < 95th percentile


Grade 2 Photophobia, CTCAE

Limiting instrumental ADL


Refractory Malignant Endocrine Neoplasm

Malignant endocrine neoplasm that is resistant to treatment.


Nutritional Rickets

Rickets due to dietary deficiency of calcium, phosphate, or vitamin D.


Refractory Post-Essential Thrombocythemia Myelofibrosis

Post-essential thrombocythemia myelofibrosis that is resistant to treatment.


Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Adenocarcinoma with metaplasia

An adenocarcinoma characterized by the presence of metaplasia.


Testis cancer recurrent

Malignant testicular germ cell tumor reemerging after a period of remission.


Grade 2 Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


Low Grade Cervical Squamous Intraepithelial Neoplasia

A precancerous neoplastic process that affects the cervical squamous epithelium without evidence of invasion. It is usually associated with human papillomavirus infection. It is characterized by the presence of mild atypia in the superficial epithelial layer that may be associated with koilocytosis. Maturation is present in the upper two thirds of the epithelium. Mitotic figures are not numerous and are present in the basal third of the epithelium.


Grade 2 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Gastric Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Lip Infection, CTCAE

Localized, local intervention indicated


Abdomen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Grade 2 Portal Vein Intra-Operative Injury, CTCAE


Pseudoangiomatous stromal hyperplasia

A benign proliferation of the stromal cells in the breast.  It is classified as simple, when associated with the presence of slit-like spaces without erythrocytes and as fascicular/proliferative, when spindle cell proliferation without atypia is present.  It is often seen in breast tissue specimens as small foci associated with benign epithelial lesions.  Pseudoangiomatous stromal hyperplasia presenting as a well-circumscribed palpable mass is rare.


autosomal recessive dyskeratosis congenita 1

Dyskeratosis congenita caused by autosomal recessive mutation(s) in the NOP10 gene, encoding H/ACA ribonucleoprotein complex subunit 3.


Unresectable Malignant Solid Neoplasm

A malignant solid neoplasm that is not amenable to surgical resection.


Grade 5 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Crushing Pain

A sense of discomfort or distress that is squeezing or excessively compressing.


Grade 1 Ophthalmoplegia and Diplopia, CTCAE


Bladder Neuroendocrine Tumor

A well-differentiated neuroendocrine neoplasm arising from the bladder. It is characterized by the presence of uniform cells with stippled chromatin and inconspicuous nucleoli. Mitotic activity is low and tumor necrosis is absent.


Stage I Prostate Cancer AJCC v8

Stage I includes: (cT1a-c, cT2a, N0, M0, PSA less than 10, Grade Group 1); (pT2, N0, M0, PSA less than 10, Grade Group 1). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. pT2: Prostate cancer which is organ confined. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. (AJCC 8th ed.)


Injection Site Reaction, CTCAE

A disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection.


Grade 3 Jejunal Perforation, CTCAE

Invasive intervention indicated


Grade 2 Colon or Cecum or Appendix Fistula, CTCAE


Grade 3 Esophagus Stricture or Stenosis, CTCAE


Grade 2 Tracheostomy Site Bleeding, CTCAE

Moderate bleeding; medical intervention indicated


Unresectable Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction adenocarcinoma that is not amenable to surgical resection.


Recurrent Anaplastic Ependymoma

The reemergence of anaplastic ependymoma after a period of remission.


Grade 1 Neutrophils and Granulocytes, CTCAE


Grade 2 Hypoparathyroidism, CTCAE

Moderate symptoms; medical intervention indicated


Grade 5 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


The presence of bacteria in the blood caused by an infected hemodialysis catheter.


Grade 3 Pancreatitis, CTCAE

Severe pain; vomiting; medical intervention indicated (e.g., analgesia, nutritional support)


Monoclonal Polymorphic Post-Transplant Lymphoproliferative Disorder


Grade 2 Neonatal Constipation, AE

An adverse event in a newborn characterized by reduced number of stools or hard stools; apparent discomfort; minor care changes indicated.


Grade 3 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Cranial Nerve III Neuropathy, CTCAE


Grade 3 Tracheal Stenosis, CTCAE

Stridor or respiratory distress limiting self care ADL; invasive intervention indicated (e.g., stent, laser)


Grade 1 Peripheral Motor Neuropathy, CTCAE

Asymptomatic; clinical or diagnostic observations only


Metastatic Carcinoma in the Pancreas

A carcinoma that has spread to the pancreas from another anatomic site.


Grade 3 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Grade 2 Edema of the Head and Neck, CTCAE


Refractory Low Grade Astrocytoma

Low grade astrocytoma that is resistant to treatment.


Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Pelvic Pain, CTCAE

Mild pain


Grade 4 Bladder Intra-Operative Injury, CTCAE


Grade 1 Vas Deferens Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Salivary Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IV Renal Pelvis and Ureter Cancer AJCC v8

Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat. N0: No regional lymph node metastasis. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm in greatest dimension; or multiple lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


TNFRSF8 Low

Indicates that low expression of TNFRSF8 has been detected in a sample.


Ampulla of Vater Neuroendocrine Tumor

A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region.


Posterior Fossa Ependymoma, Not Otherwise Specified

A circumscribed ependymoma that arises in the posterior fossa in which molecular analysis for DNA methylation profiling was unsuccessful or not reported.


Locally Advanced Prostate Adenocarcinoma

A prostatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Metastases to abdominal cavity

The spread of a malignant neoplasm from a primary site to an unspecified organ in the abdominal cavity.


Vulval Infection, CTCAE

A disorder characterized by an infectious process involving the vulva.


Grade 1 Pharyngeal Anastomotic Leak, CTCAE


Grade 3 Vasovagal Reaction, CTCAE

Present


Conjunctival Oncocytoma

A benign epithelial neoplasm that arises from the conjunctiva. It is characterized by the presence of oncocytic cells with abundant eosinophilic and granular cytoplasm.


Grade 2 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Blood Corticotrophin Decreased, CTCAE

Symptomatic; medical intervention indicated


Grade 4 Sacral Plexus Intra-Operative Injury, CTCAE


Maternal Hemorrhage

Uncontrolled bleeding from a pregnant or a woman who has recently given birth.


Rash Maculo-Papular, CTCAE

A disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritis.


Grade 2 Oral Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 5 Salivary Gland Infection, CTCAE

Death


Advanced Malignant Skin Neoplasm

A malignant neoplasm of the skin that has spread extensively to other anatomic sites or is no longer responding to treatment.


Pancreatic Alpha Cell Adenoma

A benign endocrine neoplasm arising from the alpha cells of the pancreas.  It produces glucagon.


Grade 5 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Lugano Classification Advanced Stage Hodgkin Lymphoma AJCC v8

Advanced stage Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Stage IIA Ampulla of Vater Cancer AJCC v8

Stage IIA includes: T3a, N0, M0. T3a: Tumor directly invading the pancreas (up to 0.5 cm). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Uterine Perforation, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Depressed Level of Consciousness, CTCAE

Difficult to arouse


Stage IVB Vulvar Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


Grade 4 Central Nervous System Necrosis, CTCAE


Stage III Lentigo Maligna Melanoma AJCC v7

Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Reproductive Endocrine Neoplasm

A benign or malignant endocrine neoplasm that arises from the testis or the ovary.


Grade 5 Eye Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Anemia due to Decreased Production

Anemia that results from a decreased rate of erythropoiesis.


Melanoma Metastatic in the Central Nervous System

A melanoma that has spread to the central nervous system from its original site of growth, through the hematogenous route.


Grade 3 Lymphocyte Count Decreased, CTCAE

<500-200/mm3; <0.5-0.2 x 10e9/L


Domestic injury

Trauma occurring within the confines of the home environment.


Grade 3 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


GGT Increased, CTCAE

A finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water.


Grade 3 Intracranial Hemorrhage, CTCAE

Ventriculostomy, ICP monitoring, intraventricular thrombolysis, or invasive intervention indicated; hospitalization


Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Extragonadal primary germ cell tumor mixed stage I


Grade 2 Skin Intra-Operative Injury, CTCAE


Neck Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 5 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Aortic Injury, CTCAE

Death


Increased Concomitant Drug AUC

Increased area under the plot of plasma concentration of a concomitant drug against time after its administration.


Grade 4 Laryngopharyngeal Dysesthesia, CTCAE

Life-threatening consequences


Grade 1 Esophagus Intra-Operative Injury, CTCAE


Grade 5 Neonatal Culture Positive Sepsis, AE

A culture positive sepsis adverse event in a newborn which results in death.


Grade 5 Pharyngeal Stenosis, CTCAE

Death


Childhood Aneurysmal Bone Cyst

An aneurysmal bone cyst that occurs during childhood.


Grade 4 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Neonatal Coagulation Disorder, AE

An adverse event in a newborn characterized by biochemical or clinical coagulation abnormalities; requiring intervention.


Grade 5 Injury To Carotid Artery, CTCAE

Death


Grade 3 Lip Pain, CTCAE

Severe pain; limiting self care ADL


Neonatal Sinus Tachycardia, AE

An adverse event in a newborn characterized by an abnormally high heart rate for age.


Stage IB Vulvar Cancer AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Lesion measuring more than 2 cm, or any size with stromal invasion of more than 1.0 mm, confined to the vulva and/or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


Grade 1 Other Sexual Reproductive Function, CTCAE


Grade 2 Prostatic Obstruction, CTCAE

Symptomatic; elective intervention indicated


Grade 3 Colon or Cecum or Appendix Necrosis, CTCAE


Stage IIA Pancreatic Cancer AJCC v8

Stage IIA includes: T3, N0, M0. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Lower Extremity Artery Intra-Operative Injury, CTCAE


Grade 1 Extraocular Muscle Paresis, CTCAE

Asymptomatic; clinical or diagnostic observations only


Clonal Hematopoiesis of Indeterminate Potential

A term that refers to the presence of somatic mutations in bone marrow or peripheral blood cells in individuals who may be cytopenic but do not have morphologic evidence of hematologic neoplasia. Its prevalence rises with age and is found in approximately 10% of individuals aged 70 to 80. It is associated with an increased risk of hematologic neoplasia. Mutations in the DNMT3A, TET2, or ASXL1 genes are usually identified. Approximately 10%-40% of individuals with age-related clonal hematopoiesis will progress to meet the diagnostic criteria for clonal hematopoiesis of indeterminate potential.


Grade 4 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Vagina Intra-Operative Injury, CTCAE


Blood Cardiac Troponin Increased

A laboratory test result which indicates increased levels of cardiac troponin in a biological specimen.


Pleural fistula

An abnormal communication between the pleural cavity and another anatomic site.


Grade 3 Lung Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 5 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Spermatic Cord Hemorrhage, CTCAE

A disorder characterized by bleeding from the spermatic cord.


Refractory Fibrosarcoma

Fibrosarcoma that is resistant to treatment.


Substance-Induced Anxiety Disorder

An anxiety disorder in which the symptoms of anxiety have been determined to be etiologically related to the direct physiological effects of a substance (i.e., a drug of abuse, a medication, or toxin exposure).


Grade 1 Hypoglycemia, CTCAE

<LLN-55 mg/dL; <LLN-3.0 mmol/L


Hodgkin's disease lymphocyte predominance type recurrent

An antiquated term that refers to the reemergence of either nodular lymphocyte predominant Hodgkin lymphoma or lymphocyte-rich classical Hodgkin lymphoma after a period of remission.


Clinical Stage I Esophageal Adenocarcinoma AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Rectal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 2 Sneezing, CTCAE

Moderate symptoms; medical intervention indicated


Stage IIIC Fallopian Tube Cancer AJCC v8

Stage IIIC includes: T3c, N0/N1, M0. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Grade 3 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Vascular hemorrhagic disorders

A hemorrhagic disorder that is caused by pathologic changes in the vasculature.


Grade 1 Seizure, CTCAE

Brief partial seizure and no loss of consciousness


Grade 4 Nasal Cavity Intra-Operative Injury, CTCAE


Grade 5 Myocarditis, CTCAE

Death


Pregnancy Mood Swing

The fluctuations in the mental and emotional state of an individual during pregnancy.


Adverse Event Associated with Death

An adverse event resulting in death.


Peripheral Vascular Insufficiency

A condition in which there is inadequate blood flow through the peripheral blood vessels due to intrinsic disease of the vasculature.


Rash and Dermatitis Associated with Radiation Excluding Chemoradiation, CTCAE


Grade 4 Upper Airway NOS Intra-Operative Injury, CTCAE


Child Intoxication With Breast Implant Material Ingredients

Children affected by toxins may be due to silicone breast implants and their effects on unborn children and from breastfeeding.


Grade 2 Edema Trunk, CTCAE

Readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental ADL


Grade 5 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Petroleum Hydrocarbon Compound Exposure

Environmental, occupational, or consumer-based exposure to the volatile organic compounds and polycyclic aromatic hydrocarbons that are present in and produced during refinement of petroleum products.


Grade 5 Mucositis Oral, CTCAE

Death


Grade 1 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Amnestic disorders due to a general medical condition

A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the direct physiological consequence of a general medical condition. The memory impairment is not the result of a delirium or dementia.


Advanced Gastric Small Cell Neuroendocrine Carcinoma

A gastric small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Endocrine Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Intraoperative Cardiac Injury, CTCAE

Primary repair of injured organ/structure indicated


Eczema, CTCAE

A disorder characterized by skin which becomes itchy, red, inflamed, crusty, thick, scaly, and/or forms blisters.


Subdural Hemorrhage Related to Birth

Bleeding within the subdural space occurring during labor and/or delivery.


Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma

Extrapulmonary small cell neuroendocrine carcinoma that has spread to another anatomic site.


Grade 4 Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pancreatic Mucinous-Cystic Neoplasm, Low Grade

A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of mild dysplasia and absence of mitotic figures.


Hereditary coagulation factor deficiency

An inherited blood coagulation disorder characterized by deficiency of one of the coagulation factors, resulting in bleeding.


Grade 1 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Cytomegalovirus End-Organ Disease

Tissue-invasive cytomegalovirus infection, typically seen in solid-organ transplant recipients.


Grade 5 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Fibrinogen Decreased, CTCAE

<0.25 x LLN; if abnormal, 75% decrease from baseline; absolute value <50 mg/dL


Grade 3 Hemorrhage and Bleeding, CTCAE Associated with Surgery, CTCAE


Myelofibrosis due to another disorder

Myelofibrosis that develops in patients with a history of hematologic malignancies or toxic injury to the bone marrow.


Grade 4 Spasticity, CTCAE

Life-threatening consequences; unable to move active or passive range of motion


Astler-Coller A Colon Carcinoma

Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Prostate Ductal Adenocarcinoma, Papillary Pattern

A prostate ductal adenocarcinoma characterized by the presence of a papillary growth pattern.


Grade 1 Aortic Valve Disease, CTCAE

Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging


Grade 2 Dizziness, CTCAE

Moderate unsteadiness or sensation of movement; limiting instrumental ADL


Pathologic Stage 0 Esophageal Adenocarcinoma AJCC v8

Stage 0 includes: Tis, N0, M0, GN/A. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. GN/A: Grade non-applicable. (AJCC 8th ed.)


Grade 5 Hypermagnesemia, CTCAE

Death


Grade 2 Infusion Site Extravasation, CTCAE

Erythema with associated symptoms (e.g., edema, pain, induration, phlebitis)


Early Favorable Hodgkin Lymphoma

An early Hodgkin lymphoma with favorable prognosis.


Grade 5 Neonatal Pneumothorax, AE

A pneumothorax adverse event in a newborn which results in death.


Grade 2 Salivary Gland Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Spinal Fracture, CTCAE

A finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken.


Facial Muscle Weakness, CTCAE

A disorder characterized by a reduction in the strength of the facial muscles.


Jejunal Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the jejunum.


Grade 5 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Non-Neoplastic Chronic Respiratory System Disorder

A non-neoplastic longstanding disorder of the respiratory system.


Stage IV Prostate Cancer AJCC v8

Stage IV includes: IVA: Any T, N1, M0, PSA: Any, Grade Group: Any; IVB: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. N1: Prostate cancer with metastases in regional node(s). M0: Prostate cancer without evidence of distant metastasis. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Monoclonal Paraproteinemia Present in Lower than Myeloma Levels

An indication that the detected amount of monocolonal paraproteinemia in a sample is lower than the range of levels that are associated with myeloma.


Human immunodeficiency virus leukoencephalopathy


Childhood Kidney Disorder

A kidney disorder that appears during childhood.


Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic carcinoid tumor

A carcinoid tumor that has extended beyond its original site of growth to other anatomic sites.


Grade 2 Hyperglycemia, CTCAE

Change in daily management from baseline for a diabetic; oral antiglycemic agent initiated; workup for diabetes


Grade 5 Anal Hemorrhage, CTCAE

Death


Grade 1 Thrombotic Microangiopathy, CTCAE


Grade 4 Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Phrenic Nerve Dysfunction, CTCAE


Emotional problems

A perceived issue with a person's emotional wellbeing.


Grade 4 Rectal Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Concentration Impairment, CTCAE

Moderate impairment in attention or decreased level of concentration; limiting instrumental ADL


Grade 2 Bile Duct Stenosis, CTCAE

Symptomatic; altered GI function; IV fluids indicated <24 hrs


Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Clear cell tumor

A purely morphologic term that describes a neoplasm in which all or the majority of the neoplastic cells have a clear cytoplasm, when examined under light microscopy, using the conventional staining method (H-E). This term does not provide any information about the nature of the neoplasm (benign or malignant), cell of origin (e.g. epithelial versus mesenchymal versus hematopoietic), or prognosis. Further examination using special stains and/or immunohistochemistry is required to appropriately classify this tumor.


High-CSD Melanoma

A finding indicating a high degree of cumulative sun damage in the skin as evidenced by severe solar keratosis. (WHO 2018)


Recurrent Malignant Endocrine Neoplasm

Reemergence of a malignant endocrine neoplasm after a period of remission.


Anemia due to disorders of nucleotide metabolism

A group of hemolytic anemias that result from either the deficiency or overproduction of several enzymes involved in metabolizing nucleotides.


Hyperlipidemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of lipids in blood.


Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Rectal Fissure, CTCAE

Invasive intervention indicated


Metastatic Neuroendocrine Tumor

A neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma by AJCC v8 Stage

A term that refers to the staging of adrenal gland pheochromocytoma and sympathetic paraganglioma, following the rules of the TNM AJCC v8 classification system. Parasympathetic paragangliomas are not staged because they are largely benign. This staging system does not apply to neuroendocrine tumors of the pancreas (are staged according to the classification for neuroendocrine tumors of the pancreas) and carotid body tumors (not staged). (from AJCC 8th Ed.)


Abnormal Phenolsulfonphthalein Test Result

A laboratory test result indicating other than normal parameters after a phenolsulfonphthaliein test.


Recurrent Retinoblastoma

The reemergence of retinoblastoma after a period of remission.


Radiation injury of bone marrow

Radiation injury of the hematopoietic system.


Grade 4 Cranial Nerve X Neuropathy, CTCAE


Invasive Malignant Neoplasm

Cancer that has spread beyond the layer of tissue in which it developed and is growing into surrounding, healthy tissues.


Grade 4 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Chronic Myelomonocytic Leukemia with Eosinophilia

A chronic myelomonocytic leukemia characterized by a peripheral blood eosinophil count of equal or greater than 1.5x10E9/L, and absence of PDGFRA or PDGFRB gene abnormalities.


Advanced Platinum-Resistant Malignant Germ Cell Tumor

A platinum-resistant malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Esophageal Obstruction, CTCAE

Hospitalization indicated; invasive intervention indicated; limiting self care ADL


Grade 4 Ovarian Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IIIB Fallopian Tube Cancer AJCC v8

Stage IIIB includes: T3b, N0/N1, M0. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Grade 1 Ileum Intra-Operative Injury, CTCAE


Ampulla of Vater Invasive Papillary Adenocarcinoma

An invasive adenocarcinoma that arises from an exophytic papillary neoplasm of the ampulla of Vater.


Grade 5 External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IVC Appendix Carcinoma AJCC v7

Stage IVC includes: Any T, Any N, M1b, Any G.  M1b: Nonperitoneal metastasis.  (AJCC 7th ed.)


Grade 4 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Unresectable Bladder Small Cell Neuroendocrine Carcinoma

Bladder small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Grade 4 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Myelitis, CTCAE

Moderate weakness or sensory loss; limiting instrumental ADL


Grade 3 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Repeat Expansion Disease

A class of genetic diseases that occur when microsatellite repeats expand beyond a threshold length.


Anal Adenocarcinoma within Anorectal Fistula

An anal adenocarcinoma arising from the lining of an anorectal fistulous tract.  The overlying anal mucosa does not show evidence of neoplastic changes.  Some cases are associated with Crohn disease.


idiopathic normal pressure hydrocephalus

A disorder characterized by hydrocephalus in the setting of normal cerebrospinal fluid pressure, gait apraxia, impaired cognition and urinary urgency or incontinence.


Hemorrhage and Bleeding Associated with Surgery, CTCAE


Stage IA Cutaneous Melanoma AJCC v7

Stage IA includes: T1a, N0, M0.  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and with mitosis less than 1/mm2.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 3 Phantom Pain, CTCAE

Severe pain; limiting self care ADL


Grade 3 Abdominal Distension, CTCAE

Severe discomfort; limiting self care ADL


Stage IA Fallopian Tube Cancer AJCC v6 and v7

Stage IA includes: T1a, N0, M0. T1a: Tumor limited to one tube, without penetrating the serosal surface; no ascites.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Benign Infratentorial Neoplasms

A neoplasm that arises from the infratentorial region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 4 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute Lymphoblastic Leukemia by Gene Expression Profile

Gene expression-based patient cluster groups in acute lymphoblastic leukemia.


Grade 1 Vagina Stricture or Stenosis, CTCAE


Grade 5 Peripheral Ischemia, CTCAE

Death


Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Alkalosis, CTCAE

Death


Composite paraganglioma

A neoplasm that combines morphologic characteristics of paraganglioma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor.


Grade 2 Glomerular Filtration Rate, CTCAE


Recurrent pyogenic cholangitis

A recurrent form of cholangitis that is characterized by intrabiliary pigment stone formation, biliary tree stricture and obstruction, and recurrent bouts of cholangitis. There is an association with biliary parasitosis, but evidence supporting these infections in the pathogenesis of recurrent pyogenic cholangitis is inconclusive. The most common causes of death are sepsis, liver failure, or complications from cirrhosis. Patients are also at increased risk of cholangiocarcinoma.


Grade 3 Pharyngeal Stenosis, CTCAE

Limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)


Grade 3 Lower Extremity Vein Intra-Operative Injury, CTCAE