Stage II Childhood Retinoblastoma by Toronto Guidelines v2

Enucleation with microscopic residual disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 1 Gallbladder Perforation, CTCAE

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Alkaline Phosphatase Increased, CTCAE

A finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen.


Grade 5 Colonic Obstruction, CTCAE

Death


Esophageal Glandular Intraepithelial Neoplasia

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A lesion in which the architectural and cytologic abnormalities involve either the lower or both the lower and the upper half of the esophageal glandular epithelium.


Gingival Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the gingival region.


Grade 3 CNS Necrosis and Cystic Progression, CTCAE


Cervical Yolk Sac Tumor

A yolk sac tumor that arises from the cervix. Patients present with abnormal vaginal bleeding and a polypoid, friable mass, protruding into the vagina.


Grade 1 Guillain-Barre Syndrome, CTCAE

Mild symptoms


Grade 2 Supraventricular Arrhythmia NOS, CTCAE


Anemia, CTCAE

A disorder characterized by a reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.


Pathologic Stage II Retinoblastoma AJCC v8

Stage II includes: pT4, pN0, cM0, Any H. pT4: Evidence of extraocular tumor: tumor at the transected end of the optic nerve, tumor in the meningeal spaces around the optic nerve, full-thickness invasion of the sclera with invasion of the episclera, adjacent adipose tissue, extraocular muscle, bone, conjunctiva, or eyelids. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Leukocytosis, CTCAE

A disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood.


Grade 2 Bladder Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 4 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Accessory Nerve Disorder, CTCAE

Moderate symptoms; limiting instrumental ADL


Recurrent Urethral Cancer

The reemergence of urethral carcinoma after a period of remission


Grade 3 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Neuroendocrine carcinoma, metastatic

A neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site.


Mental disorder in childhood

A category of psychiatric disorders which includes disorders most commonly identified in infancy, childhood, or adolescence.


Myelodysplastic Syndrome, Unclassifiable, with Single Lineage Dysplasia

Myelodysplastic syndrome, unclassifiable characterized by unilineage dysplasia and associated pancytopenia.


Stage I Urethral Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: For male penile urethra and female urethra: Tumor invades subepithelial connective tissue. For prostatic urethra: Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Biliary Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 3 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


malignant neoplasm of lacrimal apparatus

A primary or metastatic malignant neoplasm affecting the lacrimal gland or the lacrimal drainage system.


Recurrent Tectal Glioma

The reemergence of tectal glioma after a period of remission.


Grade 3 Vertigo, CTCAE

Severe symptoms; limiting self care ADL


Supratentorial Ependymoma, Not Elsewhere Classified

A circumscribed ependymoma that arises from the supratentorial region of the brain, characterized by the absence of a fusion gene involving ZFTA or YAP1 genes.


Systemic disease

A clinical course finding indicating that a disease presents with systemic manifestations.


Grade 2 Inner Ear Intra-Operative Injury, CTCAE


Secondary Supratentorial Anaplastic Astrocytoma

An anaplastic astrocytoma occurring in the supratentorial area secondary to a preexisting tumor.


Neonatal Pulmonary Hemorrhage, AE

An adverse event in a newborn characterized by bleeding in the respiratory tract of a neonate.


neoplasm of corpus callosum

A benign or malignant neoplasm that affects the corpus callosum.


Grade 1 Agitation, CTCAE

Mild mood alteration


Steroid Refractory Graft Versus Host Disease

Graft versus host disease that does not respond to steroid treatment.


Lugano Classification Stage II Adult Hodgkin Lymphoma AJCC v8

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Grade 2 Upper Extremity Soft Tissue Necrosis Adverse Event, CTCAE


Urinary Conduit Intra-Operative Injury, CTCAE


International Normalized Ratio of Prothrombin Time, CTCAE


Unsolicited Adverse Event

An adverse event that is voluntarily reported by a healthcare professional, consumer, or patient outside of an organized data collection system.


Desmoplastic trichoepithelioma

A benign adnexal tumor occurring in the face of young female subjects. It is characterized by the presence of epithelial neoplastic cells and keratinous cysts in a desmoplastic stroma.


Grade 5 Anorexia, CTCAE

Death


Grade 5 Hypophosphatemia, CTCAE

Death


Ampulla of Vater Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region.  It is characterized by the presence of malignant large cells.


Grade 3 Neonatal Epileptic Seizure, AE

An adverse event in a newborn characterized by electroencephalogram (EEG)-proven seizures uncontrolled with one anti-seizure drug (recurrence within three days after treatment or requiring two or more anti-seizure drugs).


Blastic Phase

Sudden increase of the number of blasts in the bone marrow and/or peripheral blood in a patient with a history of chronic leukemia.


Grade 5 Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


Defective Heavy Chain Present

An indication that cells expressing a mutated or defective form of immunoglobulin heavy chain have been detected in a sample.


Pleuritic Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the pleura.


Locally Advanced Melanoma

Melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Thoracodorsal Nerve Intra-Operative Injury, CTCAE


Grade 4 Penis Infection with Unknown Absolute Neutrophil Count, CTCAE


Hereditary Paraganglioma

A hereditary neoplasm arising from paraganglia. The majority of cases (up to 80%) are multifocal. It is caused by mutations in SDHA, SDHB, SDHC, SDHD, and SDHAF2 genes.


Grade 4 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malignant Intracranial Germ Cell Tumor

A malignant germ cell tumor that affects the structures within the cranium.


Grade 1 Irritability in Children Less Than 3 Years of Age, CTCAE


Ascites, CTCAE

A disorder characterized by accumulation of serous or hemorrhagic fluid in the peritoneal cavity.


Grade 2 Malabsorption, CTCAE

Altered diet; oral intervention indicated


Secondary Plasma Cell Leukemia

Transformation of plasma cell myeloma to plasma cell leukemia.


Grade 1 Dental and Teeth and Peridontal Pain, CTCAE


Grade 4 Spermatic Cord Stricture or Stenosis, CTCAE


Grade 3 Portal Vein Intra-Operative Injury, CTCAE


Grade 3 Hemorrhoidal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Central Nervous System Radiation Injury

Radiation injury of the central nervous system.


Grade 4 Peristomal Infection with Unknown Absolute Neutrophil Count, CTCAE


Invasive Bladder Urothelial Carcinoma Associated with Urethral Carcinoma

Invasive urothelial carcinoma of the bladder which is associated with the presence of in situ or infiltrating urethral carcinoma.


Borderline Paratesticular Mucinous Tumor

A rare, non-invasive, mucinous cystic tumor that arises from the paratesticular structures. It is characterized by the presence of irregular papillary formations with irregular branching. The papillae are lined by atypical mucinous epithelial cells. Metastases have not been reported.


Ataxia, CTCAE 5.0

A disorder characterized by lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities.


Acute Myocardial Injury with Heart Failure Related to COVID-19

Acute myocardial injury with evidence of new or worsening signs and symptoms of heart failure in a patient with probable or confirmed acute COVID-19.


Vitreous Hemorrhage, CTCAE 5.0

A disorder characterized by bleeding into the vitreous humor.


Grade 4 Gastric Necrosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Gallbladder Pain, CTCAE

Severe pain; limiting self care ADL


Recurrent Extrapulmonary Large Cell Neuroendocrine Carcinoma

The reemergence of extrapulmonary large cell neuroendocrine carcinoma after a period of remission.


Grade 1 Tracheal Mucositis, CTCAE

Endoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms


Grade 3 Radiation Excluding Chemoradiation, CTCAE


Flexural Skin Nevus

A benign nevus occurring in the flexural skin.


Anal Hemorrhage, CTCAE

A disorder characterized by bleeding from the anal region.


Grade 5 Catheter Related Infection, CTCAE

Death


Grade 3 Breast Nipple and Areolar Deformity, CTCAE


FIGO Grade 2 Endometrial Mucinous Adenocarcinoma

A primary mucinous adenocarcinoma of the endometrium that contains 6-50% non-squamous solid areas.


Grade 3 Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Sinus Intra-Operative Injury, CTCAE


Grade 4 Pulmonary Artery Intra-Operative Injury, CTCAE


Hallucinations, CTCAE

A disorder characterized by a false sensory perception in the absence of an external stimulus.


Malignant mastocytosis

A group of malignant mast cell disorders including aggressive systemic mastocytosis, mast cell leukemia, mast cell sarcoma, and systemic mastocytosis with an associated myeloid neoplasm. Individuals with advanced systemic mastocytosis have a reduced life expectancy, with median survival measured in months to years.


Grade 4 Gamma-Glutamyl Transpeptidase, CTCAE


Acute Placental Infarction

A focus of necrotic placental parenchyma with clearly visible outlines of necrotic villous structures and absence of any hyalinization and fibrosis, which is frequently 1-2 days of duration.


Grade 4 Gastroparesis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Nasal Congestion, CTCAE

Mild symptoms; intervention not indicated


Recurrent Vaginal Squamous Cell Carcinoma

The reemergence of vaginal squamous cell carcinoma after a period of remission.


Grade 2 Ejection Fraction Decreased, CTCAE

Resting ejection fraction (EF) 50-40%; 10-19% drop from baseline


Grade 5 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


High Grade Endometrioid Adenocarcinoma

Endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


Grade 1 Urostomy Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Intestinal Stoma Obstruction, CTCAE

Severe symptoms; IV fluids, tube feeding, or TPN indicated >=24 hrs; elective operative intervention indicated


Cerebellar Glioneuronal and Neuronal Tumors

Glioneuronal and neuronal tumors occurring in the cerebellum.


Grade 3 Spermatic Cord Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 5 Ventricular Arrhythmia NOS, CTCAE


Grade 4 Inferior Vena Cava Intra-Operative Injury, CTCAE


Radiation Induced DNA Damage

Damage to DNA caused by ionizing radiation.  Can cause base change mutations or strand breakage.


Anal Ulcer, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the anal canal.


Mediastinum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Temporal Lobe Pleomorphic Xanthoastrocytoma

A pleomorphic xanthoastrocytoma that arises from the temporal lobe of the brain.


Refractory Fallopian Tube Endometrioid Adenocarcinoma

Fallopian tube endometrioid adenocarcinoma that is resistant to treatment.


Grade 5 Hypernatremia, CTCAE

Death


Intermediate Osteoclastic Giant Cell-Rich Tumor of Bone

A benign but locally aggressive giant cell tumor that arises from the bone.


Stage IB Esophageal Cancer AJCC v7

Stage IB includes: For squamous cell carcinoma: (T1, N0, M0, G2-3, Tumor location: Any); (T2-3, N0, M0, G1, GX, Tumor location: Lower, X). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Vas Deferens Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures).


Stage IV Esophageal Cancer AJCC v7

Stage IV includes: For squamous cell carcinoma: Any T, Any N, M1, Any G, Tumor location: Any.  For adenocarcinoma: Any T, Any N, M1, Any G. M1: Distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Middle Ear Intra-Operative Injury, CTCAE


Rectal Mucositis, CTCAE

A disorder characterized by ulceration or inflammation of the mucous membrane of the rectum.


Childhood Ependymoma by Toronto Guidelines v2 Stage, Tier 2

A term that refers to the staging of childhood ependymoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


Grade 4 Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Cranial Nerve VI Intra-Operative Injury, CTCAE


Advanced Uterine Corpus Cancer

Uterine corpus cancer that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Intraoperative Splenic Injury, CTCAE

Primary repair of injured organ/structure indicated


Localized Pancreatic Adenocarcinoma

An adenocarcinoma that arises from the pancreas and has not spread to other anatomic sites.


Recurrent Malignant Lymphoid Neoplasm

The reemergence of a malignant lymphoid neoplasm after a period of remission.


Grade 1 Capillary Leak Syndrome, CTCAE

Asymptomatic


Grade 2 Neutrophil Count Decreased, CTCAE

<1500-1000/mm3; <1.5-1.0 x 10e9/L


Langerhans Cell Histiocytosis, Disseminated

Langerhans cell histiocytosis presenting with disseminated disease.


Grade 3 Urethra Stricture or Stenosis, CTCAE


Grade 5 Endocarditis Infective, CTCAE

Death


Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Ear and Labyrinth Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Teeth Intra-Operative Injury, CTCAE


Hyperhidrosis, CTCAE

A disorder characterized by excessive sweating.


Claudin-Low

A genetic profile indicating low expression of cellular tight junction proteins, including E-cadherin, which is often associated with triple-negative breast cancer and tumor-infiltrating lymphocytes.


Cerebrospinal Fluid Leakage, CTCAE

A disorder characterized by loss of cerebrospinal fluid into the surrounding tissues.


Grade 1 Skin Induration, CTCAE

Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)


Grade 4 Aorta Artery Intra-Operative Injury, CTCAE


Cutaneous Melanoma of the Extremity

A cutaneous melanoma that arises from the upper or lower extremity.


acute diastolic congestive heart failure

Acute congestive heart failure due to a left ventricle which does not fill properly due to decreased compliance though the ejection fraction may be preserved.


Myelodysplastic Syndrome, Unclassifiable, With 1 Percent Blasts

Myelodysplastic syndrome, unclassifiable characterized by refractory cytopenia with unilineage dysplasia or refractory cytopenia with multilineage dysplasia but with 1 percent blasts in the peripheral blood.


Hypermagnesemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood.


Fallopian Tube High Grade Serous Adenocarcinoma

A rapidly growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of high grade cytologic features and frequent mitotic figures.


Grade 3 Intraoperative Respiratory Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 2 Hemolysis, CTCAE

Evidence of hemolysis and >=2 g decrease in hemoglobin


Grade 5 Prolapse of Gastrointestinal Stoma, CTCAE


Outer Ear NOS Intra-Operative Injury, CTCAE


Urticaria, CTCAE

A disorder characterized by an itchy skin eruption characterized by wheals with pale interiors and well-defined red margins.


Grade 3 Corneal Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Occipital Diastasis

Birth trauma caused by excessive pressure to the suboccipital region of the skull resulting in separation of the occipital squama from the lateral or condylar parts of the occipital bone. It is a serious injury that may lead to subdural hemorrhage in the posterior fossa.


Medullary carcinoma

A term referring to medullary carcinomas which can develop in various anatomic sites such as the thyroid gland, breast, colon, rectum, and small intestine.


Non-Cardiac Chest Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the chest unrelated to a heart disorder.


Grade 5 Stoma Pulmonary Hemorrhage, CTCAE


Central line infection

An infectious process related to a central venous catheter.


Refractory Basal Cell Carcinoma

Basal cell carcinoma that is resistant to treatment.


Childhood Malignant Nervous System Neoplasm

A primary or metastatic malignant neoplasm that affects the nervous system and occurs during childhood.


Adrenocortical hyperplasia

Congenital or acquired hyperplasia of the cells of the adrenal cortex.


Tremor, CTCAE 5.0

A disorder characterized by the uncontrolled shaking movement of the whole body or individual parts.


Mucous cyst

A mucous containing cyst arising from the minor salivary glands in the oral cavity.


Vaginal abscess

An abscess that is located in the vagina.


Grade 1 Biliary Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Malignant tumor of optic nerve

A primary or metastatic malignant neoplasm that affects the optic nerve.


Bacillary Peliosis

An infection that is caused by Bartonella henselae, which occurs primarily in immunocompromised persons; it is characterized by blood-filled cysts in the liver and spleen.


Multifocal nodular oncocytic hyperplasia of salivary gland

A rare lesion characterized by multiple non-neoplastic nodular proliferations composed of cells with abundant granular eosinophilic cytoplasm (oncocytes) and/or clear cytoplasm (clear cells) in one or both parotid glands. (WHO 2017)


COVID-19-Associated Myalgia

Myalgia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Grade 5 Trachea Obstruction and Stenosis, CTCAE


Grade 4 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Vaginal Dryness, CTCAE 5.0

A disorder characterized by an uncomfortable feeling of itching and burning in the vagina.


Hemolytic Uremic Syndrome, CTCAE

A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.


Stage IIB Bone Cancer AJCC v7

Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Placental Malformation

A non-neoplastic abnormality that affects the placenta. Representative examples include multi-lobed and bilobed placenta.


Childhood Infectious Disorder

An infectious disorder that occurs in childhood.


Grade 1 Lumbar Spine Range of Motion, CTCAE


White Blood Cell Decreased, CTCAE

A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen.


Grade 4 Gastrointestinal Leak NOS, CTCAE


Grade 1 Mitral Valve Disease, CTCAE

Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging


Acute gonococcal infection, of upper genitourinary tract

A gonococcal infection of the upper urinary tract that is rapid in onset.


Lipidized Glioblastoma

A rare glioblastoma characterized by the presence of a predominant population of neoplastic cells with foamy cytoplasm.


Maternal Sepsis

A pathologic response to infection in a mother or pregnant woman.


Lugano Classification Advanced Stage Childhood Hodgkin Lymphoma AJCC v8

Advanced stage childhood Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Stage IV Esophageal Adenocarcinoma AJCC v7

Stage IV includes: Any T, Any N, M1, Any G.  M1: Distant metastasis.  (AJCC 7th ed.)


Grade 3 Nail Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Chest Wall Mass

An abnormal growth in the chest wall.


Grade 5 Cranial Nerve IX Neuropathy, CTCAE


Endometrial Mucinous Adenocarcinoma, Gastric-Type

A rare mucinous adenocarcinoma arising from gastric metaplasia of the endometrium.


Grade 3 Akathisia, CTCAE

Severe restlessness or increased motor activity; limiting self care ADL


Adverse Event Associated with the Lymphatic System


Grade 1 Nail Discoloration, CTCAE

Asymptomatic; clinical or diagnostic observations only


Abnormal Growth Hormone

A laboratory test result which indicates abnormal levels of growth hormone in a biologic specimen.


Grade 1 Hypertriglyceridemia, CTCAE

150 mg/dL-300 mg/dL; 1.71 mmol/L-3.42 mmol/L


Adult Anaplastic (Malignant) Meningioma

An anaplastic (malignant) meningioma occurring in adults.


Neonatal Listeriosis

A bacterial infection by Listeria monocytogenes in a newborn infant up to 28 days old.


Grade 3 Bronchopleural Fistula, CTCAE

Hospitalization; invasive intervention indicated


Grade 2 Esophageal Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 3 Menorrhagia, CTCAE

Severe; transfusion indicated; operative intervention indicated (e.g., hysterectomy)


Hyperuricemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid.


Grade 4 Otitis Middle Ear Non Infectious, CTCAE


Grade 4 Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Intraoperative Cardiac Injury, CTCAE

Death


Late effect of medical intervention

Any symptom or condition which is a result of a medical intervention but arises months or years after it.


Grade 4 Appendicitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Cutaneous Radiation Injury

Radiation injury of the skin.


Serous papillary cystic tumor of borderline malignancy

A low malignant potential cystic serous epithelial neoplasm arising from the ovary. Cases with identical morphology have been described arising from the peritoneum as well. It is characterized by an atypical epithelial proliferation and a papillary growth pattern. There is no evidence of destructive stromal invasion.


Stage I Appendix Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Genitourinary Stoma Obstruction, CTCAE


Grade 4 Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Retinopathy of Prematurity, AE

An adverse event in a newborn characterized by zone 2 International Classification of Retinopathy of Prematurity (ICROP) stage 1 with or without plus disease; zone 2 ICROP stage 2 without plus disease; zone 3 any ICROP stage; no care changes indicated.


Grade 4 Lip Or Perioral Area Intra-Operative Injury, CTCAE


Grade 5 Appendicitis, CTCAE

Death


Hyperkeratosis, CTCAE

A disorder characterized by a thickening of the outer layer of the skin.


Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


Virus-Related Malignant Neoplasm

A malignancy in which there is a well-documented association between a neoplastic process and a specific virus as the causative agent.


Grade 5 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

Death


Grade 2 Pleural Hemorrhage, CTCAE

Symptomatic or associated with pneumothorax; chest tube drainage indicated


Grade 2 Rectal Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 2 Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Low Hemoglobin Level

A lower than average level of hemoglobin in a sample.


Grade 3 Anus Intra-Operative Injury, CTCAE


Oligometastatic Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma that has metastasized to a limited number of sites.


Postpartum Obstetric Air Embolism

Presence of a large air bubble in the maternal vascular system which originated from a distant site during the postpartum period.


Grade 5 Esophageal Stenosis, CTCAE

Death


Bone Cancer by AJCC v7 Stage

A term that refers to the staging of bone cancer, following the rules of the TNM AJCC v7 classification system.


Grade 4 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE


Non-Neoplastic Heart Disorder

A non-neoplastic disorder that affects the heart and/or the pericardium.  Representative examples include congestive heart disease, endocarditis, and constrictive pericarditis.


Stage IB1 Cervical Cancer FIGO 2009

Cervical carcinoma measuring more than 5 mm in depth and equal or less than 4 cm in maximum diameter. (FIGO 2009)


Grade 3 Small Intestinal Stenosis, CTCAE

Symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated


Radiating Chest Pain in Upper Sternum

The location of the radiating chest pain is in the upper portion of the sternum.


Grade 4 Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Laryngeal Stenosis, CTCAE

Limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)


Death by strangulation

Choking or arrest of respiration due to occlusion of the air passages; arrest of circulation in a part due to compression.


Grade 3 Pyramidal Tract Syndrome, CTCAE

Severe symptoms; limiting self care ADL


Precursor T-lymphoblastic lymphoma/leukemia stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 4 Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Low Grade Squamous Intraepithelial Neoplasia

A precancerous neoplastic process characterized by the presence of mild dysplastic cytological changes which are usually present in the lower part of the squamous epithelium.  Representative examples include the low grade esophageal squamous intraepithelial neoplasia, low grade cervical squamous intraepithelial neoplasia, low grade vaginal intraepithelial neoplasia, and low grade vulvar intraepithelial neoplasia.


Grade 4 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Vaginitis Not Due to Infection, CTCAE


Depressed Level of Consciousness, CTCAE

A disorder characterized by a decrease in ability to perceive and respond.


Grade 5 Pelvis Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Chest Pain Along Right Anterior Axillary Line

The location of the chest pain is along the anterior axillary line on the right side.


Radiating Chest Pain in Mid Sternum

The location of the radiating chest pain is in the middle portion of the sternum.


intestinal type adenocarcinoma of gallbladder

An adenocarcinoma that arises from the gallbladder.  It is characterized by the presence of neoplastic tubular glands lined by columnar cells or neoplastic glands lined by goblet cells.


Typhlitis, CTCAE 5.0

A disorder characterized by necrotizing enterocolitis in neutropenic patients.


Esophageal Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the esophageal wall.


Grade 4 Lower Extremity Intra-Operative Injury, CTCAE


Stage IA Vulvar Cancer AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Lesion measuring 2 cm or less, confined to the vulva and/or perineum, and with stromal invasion of 1.0 mm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Disorder of Androgen Synthesis

An enzyme deficiency in the androgen biosynthesis pathway, resulting in the underproduction of one or more androgens by the adrenal glands and/or gonads.


Grade 3 Stomach Infection with Unknown Absolute Neutrophil Count, CTCAE


Diverticular Carcinoma of the Urinary Tract

A carcinoma that arises from a diverticulum in the urinary tract. Most histological subtypes of urinary tract carcinomas have been reported in urinary tract diverticula.


Grade 2 Perineal Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 3 Bronchopulmonary Dysplasia, AE

An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND need for greater than 30% oxygen or positive pressure at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; need for greater than 30% oxygen or positive pressure by 56 days postnatal age in infants born greater than 32 weeks' gestation; need for greater than 30% oxygen and/or positive pressure at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


Grade 2 Acoustic Nerve Disorder NOS, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 4 Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Grade 2 Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Vulval Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Stage IIA Osteosarcoma AJCC v7

Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 2 Other Pulmonary and Upper Respiratory, CTCAE


Blurred Vision, CTCAE

A disorder characterized by visual perception of unclear or fuzzy images.


Stage I Prostate Cancer AJCC v6

Stage I includes: T1, N0, M0, G1.  T1: Tumor invades subepithelial connective tissue.  N0: No regional metastasis.  M0: No distant metastasis. G1: Well differentiated (slight anaplasia) (Gleason 2-4).  (AJCC 6th ed.)


Grade 4 Pyramidal Tract Dysfunction, CTCAE


Grade 3 Edema of the Trunk and Genital Area, CTCAE


Recurrent Sclerodermatous Graft Versus Host Disease

The reemergence of sclerodermatous graft versus host disease after a period of remission.


Malignant Solitary Fibrous Tumor

A malignant neoplasm of probable fibroblastic derivation. It is characterized by the presence of atypical round to spindle-shaped cells, increased cellularity, necrotic change and high mitotic activity.


Recurrent Dedifferentiated Liposarcoma

The reemergence of dedifferentiated liposarcoma after a period of remission.


Locally Advanced Primary Malignant Central Nervous System Neoplasm

A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Anorexia, CTCAE

Associated with significant weight loss or malnutrition (e.g., inadequate oral caloric and/or fluid intake); tube feeding or TPN indicated


Grade 2 Pulmonary Valve Disease, CTCAE

Asymptomatic; moderate regurgitation or stenosis by imaging


Injury to diaphragm without mention of open wound into cavity

Trauma to the diaphragm without indication of associated damage to the skin and other internal and external tissues.


Grade 3 Prostatic Obstruction, CTCAE

Severe symptoms; invasive intervention indicated


Grade 2 Superior Vena Cava Syndrome, CTCAE

Symptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy)


Liver Dysfunction or Failure by Clinical Classification, CTCAE


Prostate Basal Cell Carcinoma

An invasive prostate carcinoma composed of prostatic basal cells.


Childhood Bone Hemangioma

A bone hemangioma that occurs during childhood.


Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils Absolute Neutrophil Count Less Than 1 X 10e9 per Liter, CTCAE


Grade 3 Palmar-Plantar Erythrodysesthesia Syndrome, CTCAE

Severe skin changes (e.g., peeling, blisters, bleeding, fissures, edema, or hyperkeratosis) with pain; limiting self care ADL


Bruising in the Absence of Grade 3 or Grade 4 Thrombocytopenia, CTCAE


Grade 5 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Immune-Mediated Coagulopathy

Disorders of coagulation caused by autoantibodies generated against native coagulation factors or therapeutically-administered hemostatic agents.


Mesenteric thrombosis

Formation of a blood clot (thrombus) in the lumen of a mesenteric vein or mesenteric artery.


Grade 4 Tongue Intra-Operative Injury, CTCAE


Grade 1 Flu Like Symptoms, CTCAE

Mild flu-like symptoms present


Grade 4 Colonic Obstruction, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Elevated Catecholamine Metabolites

A finding indicating elevated concentrations of catecholamine metabolites in a biological sample.


Grade 1 Upper Gastrointestinal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Optic Nerve Injuries

Injury to the optic nerve.


Stage IVB Cervical Cancer AJCC v9

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis including inguinal lymph nodes, lung, liver, bone, or intraperitoneal metastases. Metastases to pelvic or paraaortic lymph nodes, or vagina are excluded. (from AJCC 9th Ed.)


Grade 4 Phantom Pain Associated with Missing Limb, CTCAE


Grade 2 Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage I Low Grade Adult Non-Hodgkin's Lymphoma


Breast Neuroendocrine Tumor G2

A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the breast.


Grade 2 Rectum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Adult Myxopapillary Ependymoma

A myxopapillary ependymoma that occurs during adulthood.


Lugano Classification Stage IE Adult Lymphoma AJCC v8

Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Diffuse Astrocytoma, IDH-Wildtype

Diffuse astrocytoma lacking mutations in IDH1 or IDH2 genes.


Childhood Bone Sarcoma

A sarcoma that arises from the bone and occurs during childhood.


Infectious Meningoencephalitis

Inflammation of the meninges and brain caused by an infectious agent.


Gelatinous transformation of the bone marrow

A rare condition characterized by bone marrow fat cell atrophy, loss of hematopoietic cells, and bone marrow deposition of extracellular gelatinous substances containing mucopolysaccharides rich in hyaluronic acid. The pathogenesis is unknown. It presents with weight loss and anemia. It has been associated with infections, alcoholism, anorexia nervosa, cachexia, end stage renal disease, and cancers.


Grade 5 Non-Malignant Pericardial Effusion, CTCAE


Grade 1 Brachial Plexopathy, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 5 Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


Nodular Sclerosis Classic Hodgkin Lymphoma, Syncytial Variant


Grade 2 Restlessness, CTCAE

Moderate symptoms; limiting instrumental ADL


Immune Related Adverse Event

An adverse event affecting the immune system.


Grade 3 Thrombotic Microangiopathy, CTCAE


Ear Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the ear.


Breast Ductal Hyperplasia

Hyperplasia of the epithelial cells in the breast ducts. It includes the atypical ductal hyperplasia, papillary intraductal hyperplasia, intraductal myoepitheliosis, and ductal hyperplasia of the usual type.


Grade 3 Peritoneal Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 1 Neonatal Epileptic Seizure, AE

An adverse event in a newborn characterized by a single, self-limited electroencephalogram (EEG)-proven seizure requiring no treatment.


Secondary Parathyroid Gland Hyperplasia

Parathyroid gland hyperplasia that occurs in response to physiological stimuli (e.g., vitamin D deficiency, hyperphosphatemia, and hypocalcemia).


High Calcium Level

A higher than average level of calcium in a sample.


Metastatic Malignant Female Reproductive System Neoplasm

A malignant neoplasm that arises in the female reproductive system and has spread from its original site of growth to other anatomic sites.


Gastric Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the stomach. The Ki-67 index is higher than 20%.


Grade 5 Abdomen Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Small Bowel Stricture or Stenosis NOS, CTCAE


Locally Advanced Esophageal Carcinoma

Esophageal carcinoma that has spread to nearby tissues or lymph nodes.


Childhood Anaplastic Ependymoma

An anaplastic ependymoma that occurs during childhood.


Grade 4 Vaginal Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Tumor of the Thecoma/Fibroma Group

A sex cord-stromal tumor that arises from the ovary or the testis. Representative examples include fibroma, fibrosarcoma, and thecoma.


Grade 4 Wound Complication, CTCAE

Life-threatening consequences


Grade 3 Urinary Tract Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Testes Stricture or Stenosis, CTCAE


Fat adherence syndrome

Violation of Tenon's capsule with prolapse of orbital fat into the sub-Tenon's space.


Stage I Cutaneous Melanoma AJCC v7

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 2 Spasticity, CTCAE

Moderate increase in muscle tone and increase in resistance through range of motion


Locally Advanced Digestive System Neuroendocrine Neoplasm

A digestive system neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Non-Functioning Neuroendocrine Tumor

A non-functioning neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Urethrotrigonitis

Inflammation of both the urethra and the trigone of the urinary bladder.


Apnea, CTCAE

A disorder characterized by cessation of breathing.


Lugano Classification Stage III Hodgkin Lymphoma AJCC v8

Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Stage III Ureter Cancer AJCC v8

Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into periureteric fat. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Jugular Vein Intra-Operative Injury, CTCAE


Obstruction Gastric, CTCAE

A disorder characterized by blockage of the normal flow of the contents in the stomach.


Grade 4 Hypertension, CTCAE

Adult and Pediatric: Life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated


Grade 5 Scrotal Infection, CTCAE

Death


Injury of diaphragm

Trauma to the thoracic diaphragm.


Grade 5 Esophageal Anastomotic Leak, CTCAE

Death


Dyspnea with Mild Physical Activity

Dyspnea experienced during minimal exertion.


Meningioangiomatosis

A rare vascular malformation in the cerebral cortex and overlying leptomeninges.  It can occur sporadically or in association with neurofibromatosis type 2.


Grade 3 Delusions, CTCAE

Severe delusional symptoms; hospitalization not indicated; new onset


Grade 1 Alkalosis, CTCAE

pH >normal, but <=7.5


Unresectable Lymphoma

Lymphoma that is not amenable to surgical resection.


Grade 2 Infusion Related Reaction, CTCAE

Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs


Refractory Solitary Fibrous Tumor

Solitary fibrous tumor that is resistant to treatment.


Grade 5 Ileal Ulcer, CTCAE

Death


Grade 3 Other Metabolic and Laboratory, CTCAE


EBV-Positive Polymorphic B-Cell Lymphoproliferative Disorder, Not Otherwise Specified

An EBV-positive B-cell lymphoproliferative disorder characterized by altered tissue architecture and a polymorphic infiltrate that does not fulfill the criteria for the diagnosis of lymphoma and cannot be precisely categorized.


Deletion of the Short Arm of Chromosome 1 (1p) Associated Meningioma

A meningioma that is associated with deletion of chromosomal arm 1p.


Grade 2 INR Increased, CTCAE

>1.5-2.5; >1.5-2.5 x baseline if on anticoagulation; dose adjustment indicated


Cockade nevus

A rare speckled nevus with concentric pattern of pigmentation and central papule surrounded by clear zone.


Localized Malignant Brain Neoplasm

A malignant brain neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Heart Infection with Unknown Absolute Neutrophil Count, CTCAE


DDIT4L Acute Lymphoblastic Leukemia

A gene expression subtype of acute lymphoblastic leukemia characterized by its expression level of the DDIT4L gene.


Grade 1 Gastric Fistula, CTCAE

Asymptomatic


Childhood Peripheral Nervous System Neoplasm

A neoplasm that affects the peripheral nervous system during childhood.


Drug/Toxin-Induced Aplastic Anemia

Bone marrow failure defined as pancytopenia, due to exposure to a known toxin or drug.


Grade 2 Nasal Cavity Intra-Operative Injury, CTCAE


Germinotropic lymphoproliferative disorder caused by Human herpesvirus 8

A monotypic HHV8-positive lymphoproliferative disorder that usually occurs in HIV-negative individuals. It is characterized by the presence of HHV8-positive plasmablasts partially or completely replacing germinal centers. Coinfection with EBV is characteristic. In most cases, there is a favorable response to chemotherapy or radiation. (WHO 2017)


Unresectable Cervical Adenocarcinoma

Cervical adenocarcinoma that is not amenable to surgical resection.


Childhood Spitz Nevus

A Spitz nevus that occurs during childhood.


Grade 3 Face NOS Intra-Operative Injury, CTCAE


AIDS-Related Diffuse Mixed Cell Lymphoma

A non-Hodgkin lymphoma occurring in HIV-positive patients.  It is composed of a mixture of lymphocytes of various sizes.


Grade 2 Eye Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL; best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline


Vaginal Small Cell Neuroendocrine Carcinoma

A rare small cell neuroendocrine carcinoma that arises from the vagina.


Hyperphosphatemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of phosphate in a blood.


Grade 2 Hearing Impaired, CTCAE

Adults enrolled on a Monitoring Program (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift of >25 dB averaged at 2 contiguous test frequencies in at least one ear; Adults not enrolled on a Monitoring Program: Hearing loss with hearing aid or intervention not indicated; limiting instrumental ADL; Pediatric (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift >20 dB at 4 kHz in at least one ear


Grade 3 Hypothermia, CTCAE

32->28 degrees C; 89.6->82.4 degrees F


Grade 2 Ovary Intra-Operative Injury, CTCAE


Vulvar Cancer by AJCC v6 Stage

A term that refers to the staging of vulvar carcinoma according to the American Joint Committee on Cancer, 6th edition.


Adnexal Cribriform Carcinoma

A rare indolent adnexal carcinoma with a cribriform pattern.


Grade 5 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pancreatic Poorly Cohesive Adenocarcinoma

An adenocarcinoma that arises from the pancreas and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.


autosomal dominant dyskeratosis congenita 6

Dyskeratosis congenita caused by mutation(s) in the ACD gene, encoding adrenocortical dysplasia protein homolog.


Columnar Cell Change of the Breast

A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by one or two layers of columnar epithelial cells.  Apical cytoplasmic snouts may be present, but they are not prominent.  Secretions may be present in the lumina of the dilated acini.


Locally Advanced Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that has spread from its original site of growth to nearby tissues or lymph nodes.


Memory Impairment, CTCAE 5.0

A disorder characterized by a deterioration in memory function.


Recurrent Endometrial Endometrioid Adenocarcinoma

The reemergence of endometrial endometrioid adenocarcinoma after a period of remission.


Appendix Carcinoma by AJCC v7 Stage

A term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 7th edition. Carcinoid tumors are staged separately. (from AJCC 7th Ed.)


Persistent Adverse Event

An adverse event that extends continuously, without resolution between treatment cycles or courses.


Epistaxis, CTCAE

A disorder characterized by bleeding from the nose.


Grade 1 Stroke, CTCAE

Incidental radiographic findings only


Extra Lumbar Vertebra

A congenital anomaly of the spine, where an extra or supernumerary lumbar vertebra arises from below the 5th lumbar vertebra.


Grade 4 Obesity, CTCAE

BMI >=40 kg/m2


Stage IB1 Cervical Cancer

Stage IB1 includes: T1b1, N0, M0.  T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage III Bone Cancer AJCC v7

Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Deficiency of reductase

A deficiency in an enzyme that promotes reduction of an organic compound.


Grade 4 Cytomegalovirus Infection Reactivation, CTCAE

Life-threatening consequences; urgent intervention indicated; blindness


Grade 1 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Grade 5 Esophageal Varices Hemorrhage, CTCAE

Death


Grade 3 Recurrent Laryngeal Nerve Palsy, CTCAE

Severe symptoms; medical intervention indicated (e.g., thyroplasty, vocal cord injection)


Salivary Gland Intra-Operative Injury, CTCAE


Grade 3 Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IV Extragonadal Non-Seminomatous Germ Cell Tumor


Transient hyperinsulinism that occurs in response to neonatal stress resulting in prolonged neonatal hypoglycemia, which is distinct from transitional hypoglycemia of typical infants.


Grade 5 Trachea Infection with Unknown Absolute Neutrophil Count, CTCAE


Acute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm

An acute myeloid leukemia developing in patients with a prior history of myelodysplastic/myeloproliferative neoplasm.


Neonatal Sinus Bradycardia, AE

An adverse event in a newborn characterized by an abnormally low heart rate for age.


Grade 3 Gastroesophageal Reflux Disease, CTCAE

Severe symptoms; operative intervention indicated


Lacrimal Drainage System Melanoma

An extremely rare melanoma that arises from the lacrimal drainage system.


Metallosis

Aseptic fibrosis or local necrosis secondary to metal corrosion and release of wear debris.


Rectal Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the rectum.


Grade 5 Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Meninges Intra-Operative Injury, CTCAE


AIDS-Related Malignant Neoplasm

Malignant neoplasms that develop in HIV infected patients.  The most common AIDS-related malignant neoplasms are Kaposi sarcoma, non-Hodgkin lymphoma, anal carcinoma, cervical carcinoma, and Hodgkin lymphoma.


Unresectable Acral Lentiginous Melanoma

Acral lentiginous melanoma that is not amenable to surgical resection.


Locally Advanced Vaginal Carcinoma

Vaginal carcinoma that has spread to nearby tissues or lymph nodes.


Metastatic Pancreatic Acinar Cell Carcinoma

Pancreatic acinar cell carcinoma that has spread from its original site of growth to another anatomic site.


Cervical Cancer by AJCC v8 Stage

A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 8th edition.


Grade 3 Liver Intra-Operative Injury, CTCAE


Chemical injury

Damage to body tissue caused by exposure to a chemical substance.


Grade 4 Aspiration, CTCAE

Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Lymph Node Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in a lymph node.


Bullous Dermatitis, CTCAE

A disorder characterized by inflammation of the skin characterized by the presence of bullae which are filled with fluid.


Disseminated Juvenile Xanthogranuloma

Juvenile xanthogranuloma disseminated to extracutaneous sites including mucosal surfaces, lung, central nervous system, pituitary, lymph nodes, eye, liver, and bone marrow. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells forming nodules in the affected anatomic sites.


Stage II Anal Canal Cancer AJCC v6 and v7

Stage II includes: (T2, N0, M0); (T3,N0, M0).  T2: Tumor more than 2 cm but not more than 5 cm in greatest dimension.  T3: Tumor more than 5 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Grade 5 Metabolic or Respiratory Alkalosis, CTCAE


Recurrent Myeloid Leukemia

The reemergence of myeloid leukemia after a period of remission.


Fungemia, CTCAE

A disorder characterized by the presence of fungus in the blood stream.


Grade 4 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Restrictive Cardiomyopathy, CTCAE

Symptomatic without signs of heart failure


Grade 1 Cytomegalovirus Infection Reactivation, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Small cell glioblastoma

A morphologic variant of glioblastoma characterized by the presence of a highly proliferative and monotonous population of malignant small glial cells.


Acquired Hypogonadotropic Hypogonadism

Hypogonadotropic hypogonadism, the cause of which is not present from birth.


Grade 2 Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Grade 5 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Pharyngeal Anastomotic Leak, CTCAE

Death


Metastatic Urethral Urothelial Carcinoma

Urethral urothelial carcinoma that has spread to another anatomical site.


Childhood Appendix Neuroendocrine Tumor

A neuroendocrine tumor that arises from the appendix during childhood. It is usually located in the tip of the appendix. The vast majority of cases are grade 1 neuroendocrine tumors.


Rash and Dermatitis Associated with Chemoradiation, CTCAE


Grade 3 Muscle Weakness Left-Sided, CTCAE

Limiting self care ADL


Grade 4 Cerebrospinal Fluid Leakage, CTCAE

Life-threatening consequences; urgent intervention indicated


Childhood Lymphoma by AJCC v8 Stage

Staging systems for Hodgkin and non-Hodgkin lymphomas of childhood. Different systems are used for Hodgkin lymphoma and non-Hodgkin lymphoma of childhood. Staging of childhood Hodgkin lymphoma is the same as for the adult counterpart and is based on the Lugano classification criteria. The Ann Arbor staging system has been found to be inappropriate for staging of the non-Hodgkin lymphomas of childhood. The St. Jude staging system has been widely accepted and remains the recommended staging system for non-Hodgkin lymphomas of childhood. (from AJCC 8th Ed.)


Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


Hypoglossal Nerve Palsy

Partial or complete paralysis of the hypoglossal nerve.


Metastatic malignant neoplasm to extrahepatic bile ducts

A malignant neoplasm that has spread to the extrahepatic bile ducts from another anatomic site.  Representative examples include metastatic melanoma and metastatic breast and gastric carcinomas.


Grade 5 Penis Infection with Unknown Absolute Neutrophil Count, CTCAE


Cutaneous epithelioid angiomatoid nodule

A distinctive benign cutaneous vascular proliferation with prominent epithelioid morphology. It appears to be reactive. (WHO 2018)


Stage IIIC Cervical Cancer AJCC v9

Stage IIIC includes: IIIC1: TX, T0, T1-3, N1, M0; IIIC2: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes.  M0: No distant metastasis. (from AJCC 9th Ed.)


Cervical Microglandular Hyperplasia

A benign endocervical gland proliferation characterized by the presence of closely packed glands composed of columnar to cuboidal cells with subnuclear mucin vacuoles. It is associated with progestins or pregnancy.


immune effector cell-associated neurotoxicity syndrome, grade 3

Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0, 1, or 2, the ability of the affected individual to awaken only to tactile stimulus, clinical focal or generalized seizures that resolve rapidly, or non-convulsive seizures detected by electroencephalography (EEG) that resolve with intervention, and local cerebral edema evident on neuroimaging.


Grade 3 Peripheral Ischemia, CTCAE

Prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated


Extrahepatic Bile Duct Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. The Ki-67 index is higher than 20%.


Ampulla of Vater Somatostatin-Producing Neuroendocrine Tumor

A well differentiated neuroendocrine tumor that arises from the ampulla of Vater and the periampullary region.  It produces somatostatin.


Recurrent Adenoid Cystic Carcinoma

The reemergence of adenoid cystic carcinoma after a period of remission.


Catheter related infection

An infection that arises secondary to catheter use.


Locally Advanced Cervical Carcinoma

A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Plexiform Neurofibroma

Plexiform neurofibroma that is not amenable to surgical resection.


Prostate Cancer by AJCC v8 Stage

A term that refers to the staging of prostate cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to adenocarcinomas and squamous cell carcinomas of the prostate gland. It does not apply to sarcomas, urothelial cell carcinomas, and urothelial carcinoma of bladder involving prostate. (from AJCC 8th Ed.)


Grade 3 Spermatic Cord Obstruction, CTCAE

Severe symptoms; invasive intervention indicated


T Acute Lymphoblastic Leukemia, Not Otherwise Specified

T acute lymphoblastic leukemia in which further genetic/molecular characterization is not available.


Grade 3 Rectal Varices Hemorrhage, CTCAE


Grade 2 Salivary Gland Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 2 Pharyngeal Stenosis, CTCAE

Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


Grade 5 Chylous Ascites, CTCAE

Death


Cough, CTCAE

A disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound.


Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Jejunal Ulcer, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the jejunum.


Grade 5 Pancreatic Hemorrhage, CTCAE

Death


Grade 2 Neonatal Hypertension, AE

An adverse event in a newborn characterized by persistent or recurrent hypertension, with systolic or diastolic blood pressure between the 95th percentile and the 99th percentile.


Locally Recurrent Carcinoma

The reemergence of carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Grade 3 Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Advanced Transitional Cell Carcinoma

Transitional cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Vulvar Squamous Cell Carcinoma

Vulvar squamous cell carcinoma that is resistant to treatment.


Intraoperative Urinary Injury, CTCAE

A finding of damage to the urinary system during a surgical procedure.


Grade 4 Testicular Disorder, CTCAE

Life-threatening consequences; urgent intervention indicated


Akathisia, CTCAE

A disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs.


Grade 1 Cerebral Artery Intra-Operative Injury, CTCAE


Immune Checkpoint Inhibitor-Induced Dermatitis

Dermatitis associated with the therapeutic use of an immune checkpoint inhibitor.


Grade 2 Hypertriglyceridemia, CTCAE

>300 mg/dL-500 mg/dL; >3.42 mmol/L-5.7 mmol/L


Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Benign Supratentorial Neoplasms

A neoplasm that arises from above the cerebellar tentorium and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Hypohidrosis, CTCAE

A disorder characterized by reduced sweating.


Desmoplastic Myxoid Tumor of the Pineal Region, SMARCB1-Mutant

A SMARCB1-deficient tumor of the brain arising in the pineal region. It is characterized by the presence of spindled and epithelioid cells with low-grade morphology that are embedded in a desmoplastic stroma alternating with various extents of loose myxoid matrix.


Death by electrocution

The passage of electrical current through the body.


Grade 5 Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Bronchopleural Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Platinum-Resistant Malignant Female Reproductive System Neoplasm

A malignant female reproductive system neoplasm that progresses between one and six months of completing the last platinum therapy.


Lymphomatoid Papulosis with DUSP22-IRF4 Gene Rearrangement

A variant of lymphomatoid papulosis associated with chromosomal rearrangements involving the DUSP22-IRF4 locus at 6p25.3.


Stage IIB Cervical Cancer AJCC v6 and v7

Stage IIB includes: T2b, N0, M0.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 2 Electrocardiogram T Wave Abnormal, CTCAE

Nonspecific ST segment change


Grade 5 Skin Infection with Unknown Absolute Neutrophil Count, CTCAE


Weight Loss, CTCAE

A finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve.


Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive

The reemergence of chronic myeloid leukemia, BCR-ABL1 positive after a period of remission.


Mass lesion of brain

A benign or malignant solid pathologic process involving the brain and/or the meninges.


Grade 1 Small Intestinal Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Grade 2 Parathyroid Intra-Operative Injury, CTCAE


Grade 3 Cranial Nerve Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Disorder of AMH

Abnormally high or low anti-Müllerian hormone levels.


Childhood Gastroblastoma

A gastroblastoma that occurs during childhood.


Grade 1 Spermatic Cord Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 4 Intraoperative Hepatobiliary Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Gastric Fistula, CTCAE

Death


Squamous cell carcinoma with horn formation

A keratinizing squamous cell carcinoma characterized by the presence of horn pearls. Representative examples include squamous cell carcinomas of the face presenting as a cutaneous horn.


Grade 2 Retroperitoneal Hemorrhage, CTCAE

Self-limited; intervention indicated


Hamartoma of brain

A hamartoma that occurs in the brain.


Congenital Reproductive System Abnormality

A disorder that affects the female or male reproductive system and is present at birth. Representative examples include ovarian agenesis, vaginal agenesis, and penile agenesis.


Grade 3 Eye Pain, CTCAE

Severe pain; limiting self care ADL


Grade 4 Small Bowel Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Secondary Central Nervous System Hodgkin Lymphoma

A Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


Grade 3 Ileum Intra-Operative Injury, CTCAE


Grade 5 Pharyngeal Fistula, CTCAE

Death


Gastrointestinal Stricture and Stenosis Including Anastomotic Stricture and Stenosis, CTCAE


Grade 5 Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Serum Glutamic Oxaloacetic Transaminase, CTCAE


Abdomen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Refractory Primary Central Nervous System Neoplasm

A primary central nervous system neoplasm that is resistant to treatment.


Prostate Ductal Adenocarcinoma, Solid Pattern

A prostate ductal adenocarcinoma characterized by the presence of cribriform and/or papillary patterns and areas of solid nests of malignant cells.


Neck Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Grade 4 Vaginitis Not Due to Infection, CTCAE


Grade 5 Soft Tissue Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Bronchopleural Fistula, CTCAE

Asymptomatic


Grade 5 Serum Hypertriglyceridemia, CTCAE


Parapharyngeal abscess

An abscess that develops in the soft tissues of the lateral pharyngeal space.


Locally Advanced Ocular Melanoma

Ocular melanoma that has spread from its original site of growth to nearby tissues.


Chest Pain in Left Fifth Intercostal Space

The location of the chest pain is within the fifth intercostal space on the left side.


Grade 5 Psychiatric Disorders - Other, Specify, CTCAE

Death


Grade 2 Urethra Stricture or Stenosis, CTCAE


Refractory Malignant Leptomeningeal Neoplasm

Malignant leptomeningeal neoplasm that is resistant to treatment.


Bone Cancer by AJCC v8 Stage

A term that refers to the staging of appendicular skeleton, trunk, skull, and facial bones cancer, following the rules of the TNM AJCC v8 classification system. This staging system applies to osteosarcoma, chondrosarcoma, Ewing sarcoma, spindle cell sarcoma, hemangioendothelioma, angiosarcoma, fibrosarcoma/myofibroid sarcoma, chordoma, adamantinoma, and other cancers arising in the bone. It does not apply to primary malignant lymphoma of the bone and multiple myeloma. There are no AJCC prognostic stage groupings for spine and pelvis. (from AJCC 8th Ed.)


Intraoperative Musculoskeletal Injury

Damage to any part of the musculoskeletal system during a surgical procedure.


Lugano Classification Stage IV Childhood Hodgkin Lymphoma AJCC v8

Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


Grade 1 Ureteric Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Low Grade Fallopian Tube Serous Adenocarcinoma

A slow-growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.


Adverse Event Associated with the Heart in General


Fatigue, CTCAE 3.0

An unfavorable feeling of fatigue temporally associated with the use of a medical treatment or procedure.


Pharmacokinetic Effect Consequences

The outcome that results from chemical interactions between a drug and another drug or food.


Gait Disturbance, CTCAE

A disorder characterized by walking difficulties.


Grade 2 Bone Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Ivory Exostosis

An osteoma that develops on the surface of the bone.


Grade 3 Jejunal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Colonic Perforation, CTCAE

A disorder characterized by a rupture in the colonic wall.


Grade 2 Fallopian Tube Hemorrhage, CTCAE


Bronchial Obstruction, CTCAE

A disorder characterized by blockage of a bronchus passage, most often by bronchial secretions and exudates.


Grade 4 Ileal Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 4 Stomach Stricture or Stenosis, CTCAE


Recurrent Low Grade Fallopian Tube Serous Adenocarcinoma

The reemergence of low grade fallopian tube serous adenocarcinoma after a period of remission.


Decreased Drug AUC

Decreased area under the plot of plasma concentration of a drug against time after drug administration.


Minimal Deviation Melanoma

A melanocytic neoplasm displaying morphologic features that are intermediate between those of benign nevus and melanoma.  It is characterized by a nodular architectural growth resembling a melanoma, and a loss of nevus cell maturation.  The melanocytic cells forming the nodular growth are uniform, and they may display a high mitotic rate, but they do not show cytologic atypia.


Grade 4 Large Intestinal Anastomotic Leak, CTCAE


Adult Benign Cerebral Neoplasm

A benign neoplasm of the cerebrum occurring in adults.


Grade 2 Thrombosis or Thrombus or Embolism, CTCAE


Hemoglobinuria, CTCAE 5.0

A disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine.


Stage IIA2 Cervical Cancer FIGO 2009

Cervical carcinoma limited to the upper two-thirds of the vagina and measuring more than 4 cm in diameter. (FIGO 2009)


Prostate Acinar Pleomorphic Giant Cell Adenocarcinoma

An extremely rare prostate acinar adenocarcinoma characterized by the presence of giant, bizarre anaplastic cells with pleomorphic nuclei and lack of a spindle cell component.


Grade 1 Genitourinary Stoma Obstruction, CTCAE


Pancreatic Fistula, CTCAE

A disorder characterized by an abnormal communication between the pancreas and another organ or anatomic site.


Penile Infection, CTCAE

A disorder characterized by an infectious process involving the penis.


FIGO Stage IVA Gestational Trophoblastic Tumor


Cusp tear

A split located on a leaflet of a heart valve that prevents its complete closing, which can result in valvular dysfunction.


Disturbance in mood

A change in disposition or state of mind.


Papillary squamous cell carcinoma, non-invasive

A well differentiated squamous cell carcinoma characterized by a papillary, exophytic growth pattern, hyperkeratosis, and absence of invasion of adjacent tissues.


Grade 2 Pharyngeal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Burning Pain

A sensation of intensely hot or searing discomfort.


Grade 1 Phantom Pain, CTCAE

Mild pain


Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with Low Grade Dysplasia

An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of low grade dysplasia.


Viral endocarditis

Endocarditis caused by a viral infection.


Grade 2 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Grade 4 Hypoalbuminemia, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Pharyngeal Fistula, CTCAE

Asymptomatic


Refractory Neoplastic Post-Transplant Lymphoproliferative Disorder

Neoplastic post-transplant lymphoproliferative disorder that is resistant to treatment.


Grade 5 Other Musculoskeletal and Soft Tissue, CTCAE


Grade 3 Vas Deferens Stricture or Stenosis, CTCAE


Grade 2 Duodenum Intra-Operative Injury, CTCAE


Grade 1 Prolapse of Urostomy, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Infantile Apnea, AE

An adverse event in a newborn characterized by apnea requiring stimulation and sustained fraction of inspired oxygen (FiO2) increase; requiring non-invasive ventilation; reoccurrences requiring start of or relevant increase in dose of respiratory stimulants or other major care changes.


AHL Amyloidosis

An extremely rare type of amyloidosis characterized by the monoclonal deposition of immunoglobulin heavy chain and light chain fragments in organs and tissues.


Bone Rosai-Dorfman Disease

Rosai-Dorfman-Destombes disease affecting the bone.


Subarachnoid Hemorrhage Related to Birth

Bleeding within the subarachnoid space occurring during labor and/or delivery.


Unresectable Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that is not amenable to surgical resection.


Cushingoid, CTCAE

A disorder characterized by signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids.


Neoplasm, malignant, uncertain whether primary or metastatic

A malignant neoplasm in which the examined tissue can not be determined with certainty if it represents the primary site of tumor growth or tumor spread from another anatomic site.


Grade 5 Spermatic Cord Hemorrhage, CTCAE

Death


Non-Neoplastic Brain Disorder

A non-neoplastic disorder that affects the brain. Representative examples include cerebrovascular disorder, hydrocephalus, and encephalitis.


Grade 2 Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Small Intestinal Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel.


Grade 1 Dysgeusia, CTCAE

Altered taste but no change in diet


Presyncope, CTCAE

A disorder characterized by an episode of lightheadedness and dizziness which may precede an episode of syncope.


Stage II Bone Sarcoma AJCC v7

Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 3 Ureter Stricture or Stenosis, CTCAE


Grade 2 Colonic Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 2 Ovulation Pain, CTCAE

Present


Unresectable Urethral Urothelial Carcinoma

Urethral urothelial carcinoma that is not amenable to surgical resection.


Stage I Appendix Neuroendocrine Tumor AJCC v7

Stage I includes: T1, N0, M0. T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 3 Supraventricular Tachycardia, CTCAE

Symptomatic, urgent intervention indicated


Florid Follicular Hyperplasia Post-Transplant Lymphoproliferative Disorder

An early lesion of post-transplant lymphoproliferative disorder with the morphologic appearance of florid follicular hyperplasia.


Grade 5 Eye Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Infarction of brain due to migraine

Migraine associated with an ischemic brain lesion.


Malignant Hair Follicle Neoplasm

A neoplasm that arises from the hair follicle and metastasizes to other anatomic sites.


Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8

Stage IIIB includes: T1-4, N1b-3, M0. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Acute promyelocytic leukemia - hypogranular variant

Acute promyelocytic leukemia in which the promyelocytes in the peripheral blood have paucity or absence of cytoplasmic granules and characteristic bilobed nuclei.


Prostate Acinar Oncocytic Adenocarcinoma

An exceptionally rare acinar prostate adenocarcinoma characterized by the presence of malignant large cells with granular eosinophilic cytoplasm.


Lymphocyte Count Increased, CTCAE

A finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow.


Grade 2 Lip Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 2 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 2 Esophageal Perforation, CTCAE

Invasive intervention not indicated


Grade 2 Appendix Intra-Operative Injury, CTCAE


Spermatic Cord Obstruction, CTCAE 5.0

A disorder characterized by blockage of the normal flow of the contents of the spermatic cord.


Grade 3 Oral Pain, CTCAE

Severe pain; limiting self care ADL


Meningeal Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Infiltration of the meninges by chronic myeloid leukemia, BCR-ABL1 positive.


Stage IV Ampulla of Vater Neuroendocrine Tumor AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Congenital listeriosis

A bacterial infection by Listeria monocytogenes that is present at birth.


Mullerian Papilloma

A benign papillary neoplasm that arises from the cervix or vagina. It mostly occurs in prepubertal girls and rarely in adolescents or young adults. It is characterized by the presence of a fibrovascular core covered by cuboidal or columnar epithelial cells. Squamous metaplasia may be present. Cytologic atypia is absent.


Intraoperative Reproductive Tract Injury, CTCAE

A finding of damage to the reproductive organs during a surgical procedure.


Grade 1 Bronchial Fistula, CTCAE

Asymptomatic


Grade 5 Gastrointestinal Stoma Hemorrhage, CTCAE


Contact dermatitis due to alkali

Contact dermatitis caused by exposure to alkalis.


Radon Exposure

Inhalation of radon gas which is found in rocks, soil and groundwater as a result of radioactive decay of uranium, thorium, or radium in the environment.


Adult Diffuse Large Cell Lymphoma

A B-or T-cell non-Hodgkin lymphoma composed of a diffuse large cell lymphocytic infiltrate occurring in adults.


Aplastic anemia due to radiation

Aplastic anemia caused by excessive absorption of radiation by the bone marrow.


Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential

A premalignant neurofibromatous neoplasm characterized by the presence of at least two of the following features: cytologic atypia, hypercellularity, less than 3 mitotic figures per 10 HPFs, and loss of neurofibroma architecture. It is associated with an increased risk of progression to malignant peripheral nerve sheath tumor.


Leukemia Secondary To Oncology Chemotherapy, CTCAE

A disorder characterized by leukemia arising as a result of the mutagenic effect of chemotherapy agents.


Leg Ulcer

A circumscribed, inflammatory, and often suppurating lesion that causes necrosis of tissue on the skin of the limb comprising the hip, thigh, leg and foot.


Grade 4 Colonic Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Leukemia, Radiation-Induced

Leukemia that is caused by radiation.


Congenital anomaly of lens

Any anatomic abnormality or physiologic dysfunction of the lens of the eye that is present at the time of birth.


Average Body Weight Gain

The mean value of the amount of weight gained over a period of time.


Grade 4 Bronchial Stricture, CTCAE

Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Grade 1 Vagus Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IIIB Esophageal Cancer AJCC v7

Stage IIIB includes: For squamous cell carcinoma: T3, N2, M0, Any G, Tumor location: Any. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Activated Partial Thromboplastin Time Prolonged, CTCAE

>2.5 x ULN; bleeding


Brief depressive adjustment reaction

Temporary maladaptive depressive signs and symptoms associated with a life event.


Grade 4 Other Pulmonary and Upper Respiratory, CTCAE


Grade 1 Genitourinary Stoma Hemorrhage, CTCAE


Grade 3 Hemoglobin Increased, CTCAE

Increase in >4 g/dL


Grade 2 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Epithelioid glioblastoma

An IDH-wildtype glioblastoma characterized by the presence of large epithelioid cells with abundant eosinophilic cytoplasm, vesicular chromatin, and prominent nucleoli.


Grade 5 Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Trachea Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Lower Extremity Artery Intra-Operative Injury, CTCAE


Grade 2 Upper Airway Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Pleural Hemorrhage, CTCAE

Death


Grade 3 Urinary Tract Pain, CTCAE

Severe pain; limiting self care ADL


Grade 2 Outer Ear NOS Intra-Operative Injury, CTCAE


Eye Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Arsenical keratosis

A hyperkeratotic skin lesion that occurs in patients who have been exposed to arsenic.


Radiating Chest Pain to Other Location

An indication that the chest pain radiates to a location other than those listed.


Grade 1 Eczema, CTCAE

Asymptomatic or mild symptoms; additional medical intervention over baseline not indicated


Grade 5 Small Intestinal Anastomotic Leak, CTCAE

Death


Grade 1 Hematosalpinx, CTCAE

Minimal bleeding identified on imaging study or laparoscopy; intervention not indicated


round cell sarcoma with EWSR1-PATZ1 gene fusion

A group of rare round and spindle cell sarcomas characterized by the presence of EWSR1-PATZ1 gene fusion.


Grade 5 Ileal Obstruction, CTCAE

Death


Unresectable Neuroendocrine Carcinoma

Neuroendocrine carcinoma that is not amenable to surgical resection.


Uterine Ligament Ependymoma

A rare neoplasm that arises from the broad or other uterine ligaments and shows ependymal differentiation.


Grade 4 Urine Output Decreased, CTCAE

Adult: Anuria (<240 ml in 24 hr); Pediatric: No urine output over 12 hours


Grade 4 Spermatic Cord Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 4 Bone Intra-Operative Injury, CTCAE


Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor

A usually indolent neuroendocrine neoplasm that almost exclusively arises in the second part of the duodenum. Rare sites of involvement include jejunum, pylorus, appendix, thymus, and lung. It is a triphasic tumor consisting of a mixture of epithelioid neuroendocrine cells, Schwann-like cells, and ganglion cell-like elements.


Stage 0 Esophageal Adenocarcinoma AJCC v7

Stage 0 includes: Tis (HGD), N0, M0, G1,GX.  Tis: High-grade dysplasia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Grade 2 Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Esophageal Anastomotic Leak, CTCAE


Squamous Hyperplasia

A hyperplasia of the squamous epithelial cells.


Grade 3 Viremia, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated


Dry Desquamation

A skin reaction characterized by scaling and pruritus.


Malignant Neoplasm of Lung - Multiple Primary Sites

Lung cancer comprising malignant neoplasms from two or more sites, as determined by clinicoopathological assessment.


Epigastric hernia

Protrusion of abdominal cavity contents or pre-peritoneal fat through the abdominal wall between the umbilicus and the xiphoid process.


Grade 2 Cytomegalovirus Infection Reactivation, CTCAE

Moderate symptoms; medical intervention indicated


Lacrimal Gland Warthin Tumor

A rare benign tumor that arises from the lacrimal gland. It is characterized by an oncocytic epithelial component and dense lymphoid stroma.


Benign Dermal Neoplasm

A neoplasm that arises from the dermis and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 2 Gallbladder Obstruction, CTCAE

Symptomatic; altered GI function; IV fluids indicated <24 hrs


Grade 2 Ankle Fracture, CTCAE

Limiting instrumental ADL; outpatient operative intervention indicated


Congenital musculoskeletal anomalies

An abnormality of the musculoskeletal system that is present at birth or detected in the neonatal period.


Grade 5 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 2 Libido Decreased, CTCAE

Decrease in sexual interest adversely affecting relationship


Grade 3 Vascular Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 2 Tumor Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 5 Small Intestinal Perforation, CTCAE

Death


Cutaneous Melanoma by AJCC v7 Stage

A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v7 classification system.


Grade 4 Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Brachial Plexopathy, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 3 Peripheral Arterial Ischemia, CTCAE


Grade 3 Pleural Effusion, CTCAE

Symptomatic with respiratory distress and hypoxia; operative intervention including chest tube or pleurodesis indicated


Advanced Favorable Hodgkin Lymphoma

An advanced Hodgkin lymphoma with favorable prognosis.


Non-Neoplastic Pleural Disorder

A non-neoplastic disorder that affects the pleura.  Representative examples include pleural infection and pneumothorax.


Hypertrichosis, CTCAE

A disorder characterized by hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race.


Childhood Compound Nevus

A compound nevus that occurs during childhood.


Grade 1 Upper Airway NOS Intra-Operative Injury, CTCAE


Trigeminal nerve palsy

Partial or complete paralysis of the trigeminal nerve.


Abnormal Cardiac Study

A history of having had an abnormal cardiac study.


Grade 5 Duodenal Perforation, CTCAE

Death


Grade 2 Pharynx Obstruction and Stenosis, CTCAE


Overt Stroke

A cerebral infarction that is evident by new neurological symptoms lasting greater than 24 hours or having an area of diffusion restriction or a T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensity on an MRI of the brain that was consistent with the neurological findings.


Vital Capacity Abnormal, CTCAE

A finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value.


Pelvis Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 3 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Locally Advanced Pancreatic Carcinoma

A pancreatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Childhood Acute Erythroid Leukemia

An acute erythroid leukemia occurring in children.


Malaise, CTCAE

A disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling.


Grade 2 Hypoglossal Nerve Disorder, CTCAE


Verrucous carcinoma of the oral cavity stage I


Tracheal Stenosis, CTCAE

A disorder characterized by a narrowing of the trachea.


Grade 1 Lip Pain, CTCAE

Mild pain


Refractory Endometrial Serous Adenocarcinoma

Endometrial serous adenocarcinoma that is resistant to treatment.


Grade 2 Dyspepsia, CTCAE

Moderate symptoms; medical intervention indicated


Lacrimal Drainage System Adenoid Cystic Carcinoma

A carcinoma that arises from the lacrimal sac. It is characterized by the presence of malignant epithelial cells that form cribriform, tubular, and solid patterns.


Skin Hyperpigmentation, CTCAE

A disorder characterized by darkening of the skin due to excessive melanin deposition.


Duodenal Hemorrhage, CTCAE

A disorder characterized by bleeding from the duodenum.


Recurrent Endometrial Dedifferentiated Carcinoma

The reemergence of endometrial dedifferentiated carcinoma after a period of remission.


Pregnancy, Puerperium and Perinatal Conditions, CTCAE


Adult Benign Brain Neoplasm

A benign neoplasm of the brain occurring in adults.


Metastatic Prostate Adenocarcinoma with Neuroendocrine Differentiation

Prostate adenocarcinoma with neuroendocrine differentiation that has spread from its original site of growth to another anatomic site.


Grade 3 Myocarditis, CTCAE

Severe with symptoms at rest or with minimal activity or exertion; intervention indicated; new onset of symptoms


Grade 2 Transient Ischemic Attacks, CTCAE

Moderate neurologic deficit with or without imaging confirmation


Grade 2 Skin Hyperpigmentation, CTCAE

Hyperpigmentation covering >10% BSA; associated psychosocial impact


Grade 1 Artery NOS Intra-Operative Injury, CTCAE


Cranial Nerve I Intra-Operative Injury, CTCAE


Metastatic Platinum-Resistant Malignant Germ Cell Tumor

A platinum-resistant malignant germ cell tumor that has spread from its original site of growth to another anatomic site.


Grade 4 Neck Edema, CTCAE

Vascular or respiratory impairment requiring urgent intervention


Grade 2 Cervix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Premature Delivery, CTCAE

Delivery of a liveborn infant at >34 to 37 weeks gestation


Grade 3 Rectal Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated


Peripheral Motor Neuropathy, CTCAE

A disorder characterized by damage or dysfunction of the peripheral motor nerves.


Grade 5 Duodenal Fistula, CTCAE

Death


Adnexal Adenocarcinoma, Not Otherwise Specified

An adnexal carcinoma with ductal/glandular differentiation lacking specific histological features that would allow further classification. (WHO 2018)


A hematologic malignancy that arises in a patient with a history of organ transplantation.


Grade 3 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Ileal Perforation, CTCAE

Invasive intervention not indicated


Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 CD4 Lymphocytes Decreased, CTCAE

<200-50/mm3; <0.2 x 0.05-10e9/L


Grade 4 Neuroendocrine ACTH Deficiency, CTCAE


Childhood Benign Skin Neoplasm

A childhood neoplasm that arises from the skin and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 5 Vaginal Fistula, CTCAE

Death


Recurrent Endometrial Cancer

The reemergence of endometrial carcinoma after a period of remission.


Complex endometrial hyperplasia without atypia

A hyperplasia characterized by excessive proliferation of endometrial cells, resulting in the formation of complex epithelial structures. Epithelial atypia is absent.


Chest Wall Disorder

A non-neoplastic or neoplastic disorder that affects the structures of the chest wall.  Representative examples include infection, chest wall lipoma, and chest wall lymphoma.


Grade 3 CNS Cerebrovascular Ischemia, CTCAE


Grade 3 Encephalopathy, CTCAE

Severe symptoms; limiting self care ADL


Metastatic adenoid cystic carcinoma

An adenoid cystic carcinoma that has spread from the original site of growth to other anatomic sites.


Grade 1 Reduction in Growth Velocity, CTCAE


Epstein-Barr virus infection recurrent

An Epstein-Barr virus infection that has recurred after a period of remission.


Cervical myelocele

Herniation of spinal cord tissue and meninges through a defect in the cervical region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Metastatic Malignant Neoplasm in the Lacrimal System

A malignant neoplasm that has spread from its original site of growth to the lacrimal gland or lacrimal drainage system.


Somnolence and Depressed Level of Consciousness, CTCAE


Nutritional Hypophosphatemic Rickets

Hypophosphatemic rickets due to insufficient dietary phosphate intake or absorption.


Grade 2 Neuroendocrine Growth Hormone Secretion Abnormality, CTCAE


Grade 1 Neonatal Constipation, AE

An adverse event in a newborn characterized by reduced number of stools or hard stools; no apparent discomfort.


Grade 5 Prolonged Intubation After Pulmonary Resection, CTCAE


Adult Intracranial Germ Cell Tumor

A germ cell tumor that arises within the cranium and occurs during adulthood.


Stage I Childhood Retinoblastoma by Toronto Guidelines v2

Enucleation with negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Phlebitis of portal vein

Inflammation of the portal vein.


Grade 3 Bone Growth Limb Length Discrepancy, CTCAE


Basal-Like Prostate Carcinoma

Prostate carcinoma in which the CD49f signature is increased, the luminal markers and androgen receptor expression and signaling (androgen activity pathway) are not increased, and the proliferation score is higher than the luminal A prostate carcinoma.


Anal Fistula, CTCAE

A disorder characterized by an abnormal communication between the opening in the anal canal to the perianal skin.


Stage II Gallbladder Cancer AJCC v7

Stage II includes: T2, N0, M0.  T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 2 Laryngopharyngeal Dysesthesia, CTCAE

Moderate symptoms; mild anxiety, but no dyspnea; short duration of observation and/or anxiolytic indicated; limiting instrumental ADL


Grade 3 Urinary Fistula, CTCAE

Invasive intervention indicated


Gestational diabetes mellitus class A2

Carbohydrate intolerance first diagnosed during pregnancy. Diagnosis from abnormal oral glucose tolerance test (OGTT) and abnormal fasting or post-prandial glucose levels. Euglycemia achieved with medication.


Stage II Intermediate Grade Adult Non-Hodgkin's Lymphoma


Stage IIIA Uterine Corpus Cancer AJCC v8

Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus carcinoma or carcinosarcoma with tumor involving the serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Grade 2 Catheter Related Infection, CTCAE

Localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Tumor Lysis Syndrome, CTCAE 5.0

A disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells.


Grade 5 Feeding Intolerance, AE

A feeding intolerance adverse event in a newborn which results in death.


Grade 1 Upper Extremity Artery Intra-Operative Injury, CTCAE


Grade 4 Capillary Leak Syndrome, CTCAE

Life-threatening consequences; urgent intervention indicated


Unresectable Digestive System Carcinoma

Digestive system carcinoma that is not amenable to surgical resection.


Recurrent basal cell carcinoma

The reemergence of basal cell carcinoma after a period of remission.


Unacceptable Toxicity

Therapy-related toxicity leading to multiple treatment dose reductions or delays, early treatment stoppage, unplanned hospital admission, or death.


Grade 1 Pericarditis, CTCAE

Asymptomatic, ECG or physical findings (e.g., rub) consistent with pericarditis


Refractory Childhood Malignant Neoplasm

A childhood malignant neoplasm that does not respond to treatment.


Grade 1 Esophagitis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cutaneous Melanoma by AJCC v8 Pathologic Stage

A term that refers to the pathologic staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


Grade 4 Hepatic Failure, CTCAE

Life-threatening consequences; moderate to severe encephalopathy; coma


Current EBV Infection

Epstein-Barr virus infection is evident at the time of testing.