Grade 4 Neonatal Epileptic Seizure, AE

An adverse event in a newborn characterized by electroencephalogram (EEG)- proven seizures with life-threatening consequences (e.g. need for ventilation); status epilepticus (greater than 30 minutes of seizure activity within any 60 minute period) despite multiple anti-seizure drugs.


Concentration Impairment, CTCAE

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A disorder characterized by a deterioration in the ability to concentrate.


Grade 3 Colon or Cecum or Appendix Fistula, CTCAE


Epilepsy aggravated

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An increase in the duration or intensity of epileptic symptoms in the setting of chronic epilepsy.


Epithelioid Hemangioendothelioma with YAP1-TFE3 Gene Fusion

Epithelioid hemangioendothelioma characterized by a YAP1-TFE3 gene fusion. This gene fusion occurs in a subset of epithelioid hemangioendotheliomas characterized by the presence of well-formed vessels lined by epithelioid endothelial cells with abundant eosinophilic cytoplasm. Patients with YAP1-TFE3 gene fusion tumors tend to be younger than those with a WWTR1-CAMTA1 gene fusion.


Neoantigen-Positive Malignant Solid Neoplasm

A malignant solid neoplasm characterized by the expression of antigens resulting from cancer-specific mutations (neoantigens).


Capillary Leak Syndrome, CTCAE

A disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure.


Grade 3 Visceral Arterial Ischemia, CTCAE

Prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated


Peripheral Sensory Neuropathy, CTCAE

A disorder characterized by damage or dysfunction of the peripheral sensory nerves.


Grade 2 Personality Change, CTCAE

Moderate personality change


Lugano Classification Stage IIE Adult Hodgkin Lymphoma AJCC v8

Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Femoral Hernia with Obstruction without Mention of Gangrene

The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis, with no mention of necrosis of the herniated contents.


Grade 2 Esophagus Stricture or Stenosis, CTCAE


Postoperative Thoracic Procedure Complication, CTCAE

A finding of a previously undocumented problem that occurs after a thoracic procedure.


Grade 2 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Pancreatic Enzymes Decreased, CTCAE

Increase in stool frequency, bulk, or odor; steatorrhea


Vaginal Inflammation, CTCAE

A disorder characterized by inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge.


Refractory Ependymoma

Ependymoma that does not respond to treatment.


Bodily Pain

The sensation of acute or chronic suffering in a body region.


Stage II Osteosarcoma AJCC v7

Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 3 Testicular Disorder, CTCAE

Severe symptoms; interfering with sexual function; limiting self care ADL; intervention indicated


CRP Level Greater than or Equal to 3 mg/L

A laboratory test result indicating that C-reactive protein is present in a sample at concentrations of 3 mg/L or more.


Papulopustular Rash, CTCAE

A disorder characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back. Unlike acne, this rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions.


Grade 1 Non-Cardiac Chest Pain, CTCAE

Mild pain


Grade 2 Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


Lip Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort of the lip.


Mild Cardiac Valve Regurgitation

Evidence of mild retrograde blood flow through the valve(s) of the heart. (ACC)


Domestic Accident

An accident taking place within a home.


Grade 4 Joint Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Neuroendocrine ADH Secretion Abnormality, CTCAE


Grade 3 Intraoperative Renal Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 2 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IV Vulvar Cancer AJCC v7

Stage IV includes: IVA: (T1/T2, N3, M0); (T3, Any N, M0); IVB: (Any T, Any N, M1).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.  N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 7th ed.)


Grade 5 Voice Changes and Dysarthria, CTCAE


Stage IV Anal Canal Cancer AJCC v6 and v7

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


Grade 2 Prostatic Pain, CTCAE

Moderate pain; limiting instrumental ADL


Central Nervous System Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the brain and/or spinal cord.


Grade 5 Prolapse of Intestinal Stoma, CTCAE

Death


Transient Ischemic Attacks, CTCAE

A disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit.


Radiating Chest Pain Along Left Upper Sternal Border

The location of the radiating chest pain is along the left upper sternal border.


Grade 1 Laryngeal Hemorrhage, CTCAE

Mild cough or trace hemoptysis; laryngoscopic findings


Myeloid Neoplasms with Germline Predisposition without a Preexisting Disorder or Organ Dysfunction

Familial myeloid neoplasms associated with germline mutations without a preexisting disorder or organ dysfunction.


Grade 2 Soft Tissue NOS Intra-Operative Injury, CTCAE


Grade 4 Gastric Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Soft Tissue Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Chronic pulmonary aspergillosis

A spectrum of disorders associated with long-term Aspergillus infection of the lung that usually occur in immunocompetent individuals with underlying respiratory disorders, and may be characterized by pulmonary fibrosis or cavitation.


Middle Ear Inflammation, CTCAE

A disorder characterized by inflammation (physiologic response to irritation), swelling and redness to the middle ear.


Unresectable Digestive System Adenocarcinoma

An adenocarcinoma that arises from the gastrointestinal system and is not amenable to surgical resection.


Acquired kyphosis

Kyphosis, the cause of which is not present at birth.


Hepatic Necrosis, CTCAE 5.0

A disorder characterized by a necrotic process occurring in the hepatic parenchyma.


Cardiovascular Radiation Injury

Radiation injury of the cardiovascular system.


Grade 3 Pulmonary Valve Disease, CTCAE

Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention


COVID-19-Associated Nervous System Disorder

A central or peripheral nervous system disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Grade 2 Urinary Conduit Intra-Operative Injury, CTCAE


Grade 3 Non-Cardiac Chest Pain, CTCAE

Severe pain; limiting self care ADL


Childhood Pleomorphic Xanthoastrocytoma

A pleomorphic xanthoastrocytoma that occurs during childhood.


Glucosuria, CTCAE

A disorder characterized by laboratory test results that indicate glucose in the urine.


Grade 2 Enterocolitis, CTCAE

Abdominal pain; mucus or blood in stool


Soft Tissue Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Grade 3 Vital Capacity Abnormal, CTCAE

<50% of predicted value; limiting self care ADL


Grade 5 Recurrent Laryngeal Nerve Palsy, CTCAE

Death


Bleeding on Probing

Bleeding that is induced by gentle manipulation of the gingival tissue at the depth of the gingival sulcus.


Stage III Esophageal Cancer AJCC v7

Stage III includes: For squamous cell carcinoma: IIIA (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any); IIIB (T3, N2, M0, Any G, Tumor location: Any); IIIC (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIIA (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G); IIIB (T3, N2, M0, Any G); IIIC (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Epididymal Papillary Cystadenoma

A cystadenoma that arises from the epididymis. It is characterized by the presence of small papillary projections in the inner surface of the cysts. It may be sporadic or associated with von Hippel-Lindau disease.


Advanced Basal Cell Carcinoma

Basal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIB Bone Sarcoma AJCC v7

Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 3 Ophthalmoplegia and Diplopia, CTCAE


Grade 1 Cranial Nerve III Intra-Operative Injury, CTCAE


Grade 3 Persistent Pulmonary Hypertension of the Newborn, AE

An adverse event in a newborn characterized by Increased estimated right ventricular pressures; with severe clinical symptoms; oxygenation index greater than 25; major care changes required (e.g. inhaled nitric oxide (iNO)).


Grade 4 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Urethral Anastomotic Leak, CTCAE

Death


Grade 2 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Peritoneal Cavity Hemorrhage, CTCAE


Pathologic Stage IIA Cutaneous Melanoma AJCC v8

Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 5 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Acquired Phrenic Nerve Palsy

Damage to the phrenic nerve that results in paralysis of the hemidiaphragm and was not present at birth.


Grade 3 Genitourinary Stoma Hemorrhage, CTCAE


Grade 5 Intraoperative Endocrine Injury, CTCAE

Death


Circumscribed Meningeal Melanocytic Neoplasm

A circumscribed neoplasm that arises from leptomeningeal melanocytes. This category includes meningeal melanocytoma, meningeal melanoma, and meningeal melanocytoma of intermediate grade.


Mycosis fungoides (Working Formulation)

A peripheral (mature) T-cell lymphoma presenting in the skin with patches/plaques and it is characterized by epidermal and dermal infiltration of small to medium-sized T-cells with cerebriform nuclei.  Patients with limited disease generally have an excellent prognosis.  In the more advanced stages, the prognosis is poor. (WHO, 2001)


First degree uterine prolapse

The uterus has descended above the hymen.


Stage III Uterine Corpus Cancer AJCC v6

Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Local and/or regional spread as defined below.  T3a: Tumor invades serosa and/or adnexa (direct extension or metastasis) and/or cancer cells in ascites or peritoneal washings.  T3b Vaginal involvement (direct extension or metastasis). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic and/or para-aortic nodes.  M0: No distant metastasis. (AJCC 6th ed.)


Human Papillomavirus-Independent Vaginal Squamous Cell Carcinoma

Vaginal squamous cell carcinoma not associated with human papillomavirus infection.


Stage IIA Cervical Cancer AJCC v9

Stage IIA includes: T2a, N0, M0. T2a: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Post-streptococcal reactive arthritis

The occurrence of arthritis after infection with group A streptococcus. It is non-migratory, protracted in course, and poorly responsive to anti-inflammatory agents. (from Textbook of Pediatric Rheumatology, 6th ed. Cassidy, Petty, Laxer, and Lindsley)


Refractory Female Reproductive System Carcinoma

Female reproductive system carcinoma that is resistant to treatment.


Exercise Tolerance Test Result

The result of an evaluation of an individual's ability to endure the workload that is achieved during a specified period of exercise.


Low Grade Corneal Squamous Intraepithelial Neoplasia

A precancerous neoplastic intraepithelial process with low-grade dysplastic features involving the corneal epithelium.


Intraductal papillary neoplasm with high grade intraepithelial neoplasia

An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of severe epithelial atypia.


Grade 4 Tendon Intra-Operative Injury, CTCAE


Nuclear Cataract Grade 3

A stage of nuclear sclerotic cataract marked by pronounced yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Grade 2 Gastrointestinal Stoma Intra-Operative Injury, CTCAE


Grade 2 Irritability in Children Less Than 3 Years of Age, CTCAE


Grade 5 Upper Extremity Soft Tissue Necrosis Adverse Event, CTCAE


Platinum-Sensitive Fallopian Tube Carcinoma

Fallopian tube carcinoma that has a documented response to platinum-based chemotherapy.


Grade 4 Hearing Impaired, CTCAE

Adults: Decrease in hearing to profound bilateral loss (absolute threshold >80 dB HL at 2 kHz and above); nonservicable hearingPediatric: Audiologic indication for cochlear implant; > 40 dB HL (i.e., 45 dB HL or more); SNHL at 2 kHz and above


Gastric mucositis

An inflammatory process affecting the mucous membrane of the stomach.


Hypoxia, CTCAE

A disorder characterized by a decrease in the level of oxygen in the body.


Grade 1 Cranial Nerve IX Neuropathy, CTCAE


Stage IVA Cervical Cancer AJCC v6 and v7

Stage IVA includes: T4, Any N, M0). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (AJCC 6th and 7th eds.)


Benign neoplasm of lacrimal apparatus

A non-metastasizing neoplasm that arises from the lacrimal gland or the lacrimal drainage system.


FIGO Stage IIC Gestational Trophoblastic Tumor


Grade 2 Ventricular Tachycardia, CTCAE

Non-urgent medical intervention indicated


Grade 1 Hearing Impaired, CTCAE

Adults enrolled on a Monitoring Program (on a 1, 2, 4, 3, 6, and 8 kHz audiogram): Threshold shift of 15-25 dB averaged at 2 contiguous test frequencies in at least one ear; Adults not enrolled on a Monitoring Program: Subjective change in hearing in the absence of documented hearing loss; Pediatric (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift >20 dB hearing loss (HL) (i.e., 25 dB HL or greater); sensorineural hearing loss (SNHL) above 4 kHz (i.e., 6 or 8 kHz) in at least one ear


Lumbar myelocele

Herniation of spinal cord tissue and meninges through a defect in the lumbar region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Metastatic Infiltrating Bladder Urothelial Carcinoma, Clear Cell Variant

Bladder clear cell variant urothelial carcinoma that has spread to another anatomical site.


Grade 4 Intracranial Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Tumor Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis.


Grade 2 Non-Malignant Pleural Effusion, CTCAE


Grade 2 Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Myelodysplastic Syndrome, Unclassifiable, Based on Defining Cytogenetic Abnormality

Myelodysplastic syndrome, unclassifiable characterized by persistent cytopenia (s) with 1 percent or fewer blasts in the blood and fewer than 5% in the bone marrow, unequivocal dysplasia in less than 10 percent of the cells in one or more myeloid lineages, and cytogenetic abnormalities considered as presumptive evidence of myelodysplastic syndrome.


Achromic nevus

A benign nevus characterized by the absence of melanin pigment in the melanocytes.


Papillary neoplasm

A benign, intermediate, or malignant neoplasm characterized by the formation of papillary structures.


Grade 4 Uterus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Childhood Langerhans Cell Histiocytosis without Risk Organ Involvement

Langerhans cell histiocytosis that occurs during childhood and does not involve the bone marrow, spleen, liver, or lung.


Grade 2 Hyperphosphatemia, CTCAE

Noninvasive intervention indicated


Esophageal adenocarcinoma stage IV

An adenocarcinoma that arises from the esophagus and has metastasized to another anatomic site.


Advanced Carcinoid Tumor

A carcinoid tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Destructive Arthritis

Arthritis associated with the destruction of the cartilage and the articular surface of the bone of the joint. This process severely interferes with movement in the joint.


Grade 2 Laryngospasm, CTCAE

Transient episode; intervention not indicated


Lymphoma by Ann Arbor Stage

An anatomic stage for Hodgkin and non-Hodgkin lymphomas  based on the Ann Arbor classification criteria.


Lower Extremity Vein Intra-Operative Injury, CTCAE


Bilateral glaucoma

Increased pressure in both eyeballs due to obstruction of the outflow of aqueous humor.


Chest Pain Along Left Midclavicular Line

The location of the chest pain is along the left midclavicular line.


Recurrent Childhood Malignant Neoplasm

The reemergence of a childhood malignant neoplasm after a period of remission.


Grade 4 Aspartate Aminotransferase Increased, CTCAE

>20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal


Grade 1 Recurrent Laryngeal Nerve Palsy, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Locally Advanced Malignant Female Reproductive System Neoplasm

A malignant female reproductive system neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Intraoperative Reproductive Tract Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Intercalated Duct Hyperplasia

A salivary ductal proliferation resembling intercalated ducts. (WHO 2017)


Childhood Diabetes Mellitus

Diabetes mellitus that develops during childhood.


Grade 3 Vein NOS Intra-Operative Injury, CTCAE


Grade 2 Pancreatic Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Precursor T-lymphoblastic lymphoma/leukemia recurrent

The reemergence of T-lymphoblastic leukemia/lymphoma after a period of remission.


Vaginal Undifferentiated Carcinoma

A carcinoma that arises from the vagina and is characterized by the lack of specific cellular differentiation.


Neuroendocrine Gonadotropin Secretion Abnormality, CTCAE


Musculoskeletal Chest Pain due to Costochondritis

A condition in which there is musculoskeletal chest pain associated with inflammation of one or more ribs and/or cartilages. (ACC/AHA)


Grade 2 Platelet Count Decreased, CTCAE

<75,000-50,000/mm3; <75.0-50.0 x 10e9/L


Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8

Stage IV includes: IVA: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G); IVB: (Any T, Any N, M1, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Cutaneous Mature T-Cell and NK-Cell Neoplasm

A group of neoplasms composed of T-lymphocytes with a mature (peripheral/post-thymic) immunophenotypic profile and/or NK-cells affecting the skin.


Refractory Adenocarcinoma

An adenocarcinoma that does not respond to treatment.


EBV-Related Hodgkin Lymphoma

Hodgkin lymphoma that is caused by Epstein-Barr virus infection.


Grade 2 Extraocular Muscle Paresis, CTCAE

Unilateral paresis without double vision


High Grade Pancreatic Intraepithelial Neoplasia

A pancreatic epithelial neoplasia characterized by the presence of papillary and rarely flat architectural patterns with formation of cribriform patterns and luminal necrosis.  Severe dysplasia is present.


Grade 1 Urinary Tract Pain, CTCAE

Mild pain


Intraoperative Hemorrhage, CTCAE

A finding of uncontrolled bleeding during a surgical procedure.


Grade 2 Sore Throat, CTCAE

Moderate pain; limiting instrumental ADL


Grade 1 Outer Ear NOS Intra-Operative Injury, CTCAE


Neonatal Respiratory Insufficiency, AE

An adverse event in a newborn characterized by significant impairment of gas exchange resulting in compensatory breathing efforts and eventually hypoxia and/or hypercarbia. Note: Consider this adverse event for any patient whose respiratory condition deteriorates from baseline. If any specific diagnosis is identified: use diagnosis-specific scale (e.g. respiratory distress syndrome (RDS), pulmonary hemorrhage).


Ileal Ulcer, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the ileum.


Neuroendocrine carcinoma of appendix

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the appendix. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Grade 2 Brain Intra-Operative Injury, CTCAE


Grade 4 Stroke, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Colonic Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Locally Advanced Neuroendocrine Carcinoma

A neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Gallbladder Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Adrenal Insufficiency, CTCAE

A disorder characterized by the adrenal cortex not producing enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency.


Grade 3 Ileus, CTCAE

Severely altered GI function; TPN indicated; tube placement indicated


Grade 4 Disseminated Intravascular Coagulation, CTCAE


Remote Placental Infarction

A focus of necrotic placental parenchyma with marked hyalinization and fibrosis with complete absence of the necrotic chorionic villi, which is frequently more than 7 days of duration.


Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8

Stage IIA includes: (T2, N0, M0, G3); (T2, N0, M0, GX). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Social Circumstances - Other, Specify, CTCAE


Stage IIIB Bladder Cancer AJCC v8

Stage IIIB includes: T1-T4a, N2, N3, M0. T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N2: Multiple regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node metastasis). N3: Lymph node metastasis to the common iliac lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Spine Kyphosis or Lordosis, CTCAE


Grade 3 Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Stage I Fallopian Tube Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 5 Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage I Vulvar Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Prolapse of Gastrointestinal Stoma, CTCAE


Stage IV Bladder Cancer AJCC v8

Stage IV includes: IVA: (T4b, N0, M0); (Any T, Any N, M1a); IVB: (Any T, Any N, M1b). T4b: Extravesical tumor invades pelvic wall, abdominal wall. N0: No regional lymph node metastasis. M0: No distant metastasis. M1a: Distant metastasis limited to lymph nodes beyond the common iliacs. M1b: Non-lymph node distant metastases. (AJCC 8th ed.)


Grade 1 Irritability, CTCAE

Mild; easily consolable


Sharp Pain

A sensation of discomfort or distress that is distinct and intensely focused.


Grade 3 Spasticity, CTCAE

Severe increase in muscle tone and increase in resistance through range of motion


Helicobacter Pylori-Related Gastric Adenocarcinoma

An adenocarcinoma that arises from the gastric mucosa and is caused by persistent infection with Helicobacter pylori.


Locally Advanced Transitional Cell Carcinoma

Transitional cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Gastrointestinal Fistula, CTCAE

Invasive intervention indicated


Grade 4 Supraventricular Tachycardia, CTCAE

Life-threatening consequences


Grade 3 Laryngitis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 3 Neonatal Convulsion, AE

An adverse event in a newborn characterized by suspected seizures uncontrolled with one anti-seizure drug (recurrence within three days after treatment or requiring two or more anti-seizure drugs).


Grade 1 Lower Gastrointestinal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 3 Gastric Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 Skin Infection with Unknown Absolute Neutrophil Count, CTCAE


Chemical esophagitis

Esophagitis secondary to chemical exposure.


Endocrine disorder arising from mental factors

An endocrine disorder that is caused by abnormal mental function.


Grade 5 Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Recurrent Childhood Oligodendroglioma

The reemergence of oligodendroglioma in childhood after a period of remission.


Grade 4 Personality Change, CTCAE

Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Brachial Plexus Intra-Operative Injury, CTCAE


Grade 4 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

Life-threatening consequences


Glucose Intolerance, CTCAE

A disorder characterized by an inability to properly metabolize glucose.


Familial Testicular Germ Cell Tumor

Germ cell tumor that arises from the testis and is diagnosed in at least two relatives.


Grade 2 Colitis, CTCAE

Abdominal pain; mucus or blood in stool


Grade 2 Neck Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Ileal Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the intestinal contents in the ileum.


Floaters, CTCAE

A disorder characterized by an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens.


Stage II Adult Diffuse Small Cleaved Cell Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Immune System and Related Disorders

A group of non-neoplastic and neoplastic disorders resulting from the deregulation and/or deficiency of immune system functions. It includes autoimmune disorders (e.g., lupus erythematosus, dermatomyositis, rheumatoid arthritis), congenital and acquired immunodeficiency syndromes including the acquired immune deficiency syndrome (AIDS), and neoplasms (e.g., lymphomas and malignancies secondary to transplantation).


Grade 5 Hyperphosphatemia, CTCAE

Death


Grade 1 Bile Duct Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Cervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma

A carcinoma that arises from the cervix and is characterized by the presence of a cervical adenocarcinoma variant and a neuroendocrine carcinoma component.


Phrenic Nerve Palsy Related to Birth

A condition characterized by reduced or absent movement of the ipsilateral diaphragm as a consequence of an injury to the phrenic nerve or its origin in cervical roots 3 through 5 sustained during the birthing process.


Carotid Artery Intra-Operative Injury, CTCAE


Metastatic Malignant Neoplasm in the Visual Pathway

A malignant neoplasm that has spread to the visual pathway from another anatomic site.


Grade 2 Hydrocephalus, CTCAE

Moderate symptoms; intervention not indicated


Grade 4 Somnolence and Depressed Level of Consciousness, CTCAE


Grade 2 Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Advanced Ampulla of Vater Carcinoma

Carcinoma that arises from the ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IVA Bladder Cancer

Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1 : T4b: Tumor invades the pelvic wall, abdominal wall. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M1: Distant metastasis.


Moderately Differentiated Malignant Neoplasm

A neoplasm whose histologic characteristics are intermediate between poorly differentiated and well differentiated.


Refractory Urothelial Carcinoma

Urothelial carcinoma that does not respond to treatment.


Nuclear Cataract Grade 1

A stage of nuclear sclerotic cataract marked by mild yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Grade 4 Genitourinary Stoma Stricture or Stenosis, CTCAE


Grade 2 Thrush, CTCAE

Oral intervention indicated (e.g., antifungal)


Grade 1 Infusion Site Extravasation, CTCAE

Painless edema


Grade 3 Facial Muscle Weakness, CTCAE

Severe symptoms; limiting self care ADL


Stage IVA Gestational Trophoblastic Tumor AJCC v7

Stage IVA includes: Any T, M1b, Risk factors: low risk.  M1b: All other distant metastasis.  (AJCC 7th ed.)


Grade 5 Thrombosis or Embolism Vascular Access Related, CTCAE


Refractory Malignant Glioma

Malignant glioma that does not respond to treatment.


Grade 2 Urostomy Obstruction, CTCAE

Symptomatic; dilation or endoscopic repair or stent placement indicated


Dry Mouth, CTCAE

A disorder characterized by reduced salivary flow in the oral cavity.


Grade 4 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Bronchus Obstruction and Stenosis, CTCAE


Retinopathy, CTCAE

A disorder involving the retina.


Grade 2 Gallbladder Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Malignant Neoplasm by Grade

A term that refers to the categorization of malignant neoplasm by histologic grade.


Grade 1 Hot Flashes, CTCAE

Mild symptoms; intervention not indicated


Stage IIA Cervical Cancer FIGO 2009

Cervical carcinoma limited to the upper two-thirds of the vagina. (FIGO 2009)


Grade 5 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Perinatal Brain Injury

Injury to the brain of a newborn infant occurring around the time of birth.


Vascular implant infection

An infectious process originating from an implanted vascular device.


Renal Hemorrhage, CTCAE

A disorder characterized by bleeding from the kidney.


Opisthorchis viverrini Infection

An infection caused by the parasite Opisthorchis viverrini. It results from the ingestion of raw or undercooked food. The clinical features vary from mild to severe and include gastrointestinal symptoms, anorexia, weight loss, hepatomegaly, and cholangitis. Patients are at an increased risk of developing cholangiocarcinoma.


Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Fallopian Tube Undifferentiated Carcinoma

The reemergence of fallopian tube undifferentiated carcinoma after a period of remission.


Grade 4 Sinus Intra-Operative Injury, CTCAE


Activated Partial Thromboplastin Time Prolonged, CTCAE

A finding based on laboratory test results in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment.


Grade 5 CNS Cerebrovascular Ischemia, CTCAE


Conjunctival Lymphangioma

A lymphangioma that arises from the conjunctiva.


perinatal respiratory distress

A pathological increase in the effort and frequency or breathing movements during the perinatal period.


Castleman Disease, Plasma Cell Type

Castleman disease characterized by the presence of prominent hyalinized vessels in the germinal centers and prominent sheets of plasma cells in the interfollicular areas.


Grade 3 Lip Or Perioral Area Intra-Operative Injury, CTCAE


Vaso-Occlusive Crisis in Sickle Cell-SS Disease

Sickle cell-SS disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.


Grade 2 Neonatal Convulsion, AE

An adverse event in a newborn characterized by suspected seizures controlled with one anti-seizure drug (no recurrence within three days after treatment).


Grade 4 Vaginal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


CALLA Positive Lymphoblastic Leukemia

Acute lymphoblastic leukemia which is positive for the common acute lymphoblastic leukemia antigen.


Grade 3 Leukoencephalopathy Radiographic Findings, CTCAE


Movements Involuntary, CTCAE

A disorder characterized by uncontrolled and purposeless movements.


Gastric Mixed Adenocarcinoma

An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of both glandular and poorly cohesive malignant cellular components.


Grade 2 Postoperative Thoracic Procedure Complication, CTCAE

Extubated within 24-72 hrs postoperatively


Grade 2 Rectal Mucositis, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Grade 3 Lymph Leakage, CTCAE

Severe symptoms; invasive intervention indicated


Liposarcoma non-metastatic

Liposarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Non-Neoplastic Disorder

Any disorder other than abnormal tissue growth resulting from uncontrolled cell proliferation.


Stage II Ampulla of Vater Neuroendocrine Tumor AJCC v8

Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading through the sphincter of Oddi into duodenal submucosa or muscularis propria, or measuring more than 1 cm. T3: Tumor invading the pancreas or peripancreatic adipose tissue. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Locally Advanced Midgut Neuroendocrine Tumor

A midgut neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Genitourinary Stoma Hemorrhage, CTCAE


Lugano Classification Stage II Bulky Childhood Hodgkin Lymphoma AJCC v8

Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Increased Red Cell Mass

An indication that the portion of total blood volume occupied by erythrocytes in a sample have increased when compared to normal levels or a previous measurement.


Grade 3 Cartilage Intra-Operative Injury, CTCAE


Central Nervous System Vascular Malformations

A congenital abnormality of the arteries and veins that is located in the brain or spina cord, and which may increase the risk of bleeding, possibly resulting in impaired mental or physical function.


Spindle cell nodule

A benign, reactive lesion occurring status post instrumentation; histologic examination demonstrates a fascicular growth pattern of plump or elongated spindle cells infiltrating the wall of an organ without atypia or necrosis.


Grade 2 Ileal Stenosis, CTCAE

Symptomatic; altered GI function


Grade 3 Duodenal Obstruction, CTCAE

Hospitalization indicated; invasive intervention indicated


Recurrent Male Reproductive System Carcinoma

The reemergence of a carcinoma that affects the male reproductive system after a period of remission.


Grade 4 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Corneal Infection, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Nonresorbable Material Unretrieved In Body


Locally Advanced Neuroendocrine Neoplasm

A neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IA2 Cervical Cancer AJCC v8

Stage IA2 includes: T1a2, Any N, M0. T1a2: Invasive cervical carcinoma with measured stromal invasion of more than 3.0 mm and not more than 5.0 mm, with a horizontal spread of 7.0 mm or less. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 2 Hirsutism, CTCAE

In women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact


Intracranial Melanoma

A melanoma that arises from the structures within the cranium.


Grade 4 Hepatic Artery Intra-Operative Injury, CTCAE


Chest Pain in Right Third Intercostal Space

The location of the chest pain is within the third intercostal space on the right side.


Adnexitis

Inflammation of the appendages of the uterus.


Grade 5 Bronchopulmonary Hemorrhage NOS, CTCAE


Injury To Jugular Vein, CTCAE

A finding of damage to the jugular vein.


Metastatic Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma that has spread to other anatomic sites.


Grade 5 Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


Vulvar Cancer by AJCC v7 Stage

A term that refers to the staging of vulvar carcinoma according to the American Joint Committee on Cancer, 7th edition.


Genitourinary Cancer

A primary or metastatic malignant neoplasm that affects the genitourinary system.


COVID-19-Associated Thromboembolism

Thromboembolism caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Hemangioblastic Meningioma

An obsolete term referring to hemangiopericytoma of the central nervous system.


Grade 4 Dysphagia, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage IV Gallbladder Cancer AJCC v8

Stage IV includes: IVA: T4, N0-1, M0; IVB: (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invading the main portal vein or hepatic artery or invading two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. N2: Metastases to four or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Recurrent Neuroendocrine Neoplasm

The reemergence of a neuroendocrine neoplasm after a period of remission.


Neuroendocrine Growth Hormone Secretion Abnormality, CTCAE


Grade 3 Depression, CTCAE

Severe depressive symptoms; limiting self care ADL; hospitalization not indicated


Grade 2 Laryngeal Edema, CTCAE

Symptomatic; medical intervention indicated (e.g., dexamethasone, epinephrine, antihistamines)


Loss of BRG1 Protein Expression

An immunohistochemical finding indicating negative staining of tumor cells for BRG1 protein, resulting from the mutation of the SMARCA4 gene.


Grade 4 Vagina Stricture or Stenosis, CTCAE


Obesity-Related Malignant Neoplasm

A malignant neoplasm that occurs in the context of obesity.


Arteritis Infective, CTCAE

A disorder characterized by an infectious process involving an artery.


Decreased Concomitant Drug Level

A reduction in the level of a concomitant drug.


Renal Pelvis and Ureter Cancer by AJCC v7 Stage

A term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 7th edition.


Grade 1 Jejunal Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Adult Acute Basophilic Leukemia

An acute basophilic leukemia occurring in adults.


Grade 4 White Blood Cell Decreased, CTCAE

<1000/mm3; <1.0 x 10e9/L


Benign Genitourinary System Neoplasm

A non-metastasizing neoplasm that arises from the genitourinary system.


Grade 5 Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Major Visceral Artery Intra-Operative Injury, CTCAE


Grade 5 Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Factor I Inactivation

Presence of inactivating antibodies to fibrinogen (factor I) in the blood.


Grade 2 Rectum Stricture or Stenosis, CTCAE


Grade 2 Injection Site Reaction, CTCAE

Pain; lipodystrophy; edema; phlebitis


Grade 3 Hypoalbuminemia, CTCAE

<2 g/dL; <20 g/L


Stage I Pancreatic Cancer AJCC v8

Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Frotteurism

A disorder characterized by recurrent sexual urges, fantasies, or behaviors involving touching the genitals of or rubbing the genitals against a nonconsenting person.


Grade 2 Peristomal Infection with Unknown Absolute Neutrophil Count, CTCAE


Cyst of Skene's duct

A rare benign lesion that arises from the vagina. It is characterized by the presence of squamous epithelial and tubular structures in a fibrovascular stroma.


Radiating Chest Pain in Lower Sternum

The location of the radiating chest pain is in the lower portion of the sternum.


Grade 4 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Renal and perinephric abscess

An abscess that is located both in the kidney and across the renal capsule into the perinephric space.


Grade 5 Intraoperative Gastrointestinal Injury, CTCAE

Death


Unresectable Fallopian Tube Adenocarcinoma

Fallopian tube adenocarcinoma that is not amenable to surgical resection.


Polycythemia Vera, Polycythemic Phase

Polycythemia vera characterized by the proliferation of the erythroid, granulocytic, and megakaryocytic lineages. The peripheral blood shows excess of red blood cells, neutrophilia, and thrombocytosis. The bone marrow is hypercellular for the patient's age.


Grade 4 Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Meningismus, CTCAE

Severe symptoms; limiting self care ADL


Adenocarcinoma in situ in tubulovillous adenoma

A non-invasive adenocarcinoma arising from a tubulovillous adenoma.


Leukoencephalopathy, CTCAE

A disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.


Grade 1 Neonatal Hypotension, AE

An adverse event in a newborn characterized by transient (less than 60 minutes), asymptomatic hypotension; not affecting perfusion; not requiring intervention.


Infectious mononucleosis-like post-transplant lymphoproliferative disorder

An early post-transplant lymphoproliferative lesion characterized by immunoblastic proliferation and paracortical expansion as seen in infectious mononucleosis.  There is architectural preservation of the involved tissues.  Oligoclonal or monoclonal cellular populations have been detected in a small number of cases.  In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion.


Grade 4 Tracheostomy Site Bleeding, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Dry Eye, CTCAE

Asymptomatic; clinical or diagnostic observations only; symptoms relieved by lubricants


Recurrent Myxoid Liposarcoma

The reemergence of myxoid liposarcoma after a period of remission.


Stage II Gastric Cancer AJCC v6

Stage II includes: (T1, N2, M0), (T2a/b, N1, M0), (T3, N0, M0).  T1: Tumor invades lamina propria or submucosa. T2: Tumor invades muscularis propria or submucosa.  T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa.  T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. N1: Metastasis in 1 to 6 regional lymph nodes. Metastasis in 7 to 15 regional lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.)


Cystic Oncocytic Neoplasm

An oncocytoma with cystic degenerative changes.


Grade 1 Hypertrichosis, CTCAE

Increase in length, thickness or density of hair that the patient is either able to camouflage by periodic shaving or removal of hairs or is not concerned enough about the overgrowth to use any form of hair removal


Decreased Drug Half Life

Decreased period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.


Photosensitivity, CTCAE

A disorder characterized by an increase in sensitivity of the skin to light.


Grade 2 Hypothermia, CTCAE

35->32 degrees C; 95->89.6 degrees F


Cervix Infection with Unknown Absolute Neutrophil Count, CTCAE


Sarcoma by FNCLCC Grade

Grading of sarcomas according to the French Federation of Cancer Centers Sarcoma Group (FNCLCC). This sarcoma grading system is based on three factors: differentiation, mitotic count, and tumor necrosis. The scores for each factor are added to determine the grade (1 to 3) for the sarcoma.


Grade 1 Delirium, CTCAE

Mild acute confusional state


Compound nevus

A nevus composed of neoplastic melanocytes that infiltrate both the epidermis and the dermis.


Hodgkin's disease mixed cellularity stage I supradiaphragmatic


Unresectable Gallbladder Carcinoma

A carcinoma that arises from the gallbladder and it is not amenable to surgical resection.


Cecum Perforation, CTCAE

Cecum Perforation that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


Elevated Serum CA 27-29 Tumor Antigen Levels


Intraoperative Pain

Pain occurring during a surgical operation.


Stage IIIA Cutaneous Melanoma AJCC v7

Stage IIIA includes: (T1-4a, N1a, M0); (T1-4a, N2a, M0).  T1-4a: Non-ulcerated cutaneous melanoma of any thickness.  N1a: Cutaneous melanoma with micrometastasis in one regional lymph node.  N2a: Cutaneous melanoma with micrometastases in 2-3 regional lymph nodes.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Breast Columnar Cell Hyperplasia with Atypia

A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by more than two layers of columnar epithelial cells.  Cytologic atypia is present.  Prominent apical cytoplasmic snouts and intraluminal secretions are also present.


Grade 3 Cervix Intra-Operative Injury, CTCAE


Grade 5 Chronic Kidney Disease, CTCAE

Death


Nail Changes, CTCAE 5.0

A disorder characterized by a change in the nails.


Resectable Liposarcoma

Liposarcoma that is amenable to surgical resection.


Stage IIIC Testicular Cancer AJCC v8

Stage IIIC includes: (Any pT/TX, N1-3, M0, S3); (Any pT/TX, Any N, M1a, S3); (Any pT/TX, Any N, M1b, Any S). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. M1b: Testicular cancer with non-pulmonary visceral metastases. S3: LDH more than 10 x N or hCG (mlU/mL) more than 50,000 or AFP (ng/mL) more than 10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Recurrent Adult Acute Lymphoblastic Leukemia

The reemergence of acute lymphoblastic leukemia in adults after a period of remission.


Grade 3 Hypophysitis, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 5 Cranial Nerve V Neuropathy, CTCAE


Biliary Intraepithelial Neoplasia-1

Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial atypia.


Grade 4 Joint Intra-Operative Injury, CTCAE


Grade 4 Ileal Perforation, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Cranial Nerve XI Intra-Operative Injury, CTCAE


Primary Graft Failure After Hematopoietic Cell Transplantation

Failure of initial engraftment of donor hematopoietic cells.


Refractory Aggressive NK-Cell Leukemia

Aggressive NK-cell leukemia that is resistant to treatment.


Grade 2 Malaise, CTCAE

Uneasiness or lack of well being limiting instrumental ADL


Grade 3 Spinal Fracture, CTCAE

Severe back pain; hospitalization or intervention indicated for pain control (e.g., vertebroplasty); limiting self care ADL; disability


Grade 1 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Grade 5 Peritoneal Necrosis, CTCAE

Death


Cystitis Noninfective, CTCAE

A disorder characterized by inflammation of the bladder which is not caused by an infection of the urinary tract.


Grade 5 Intraoperative Splenic Injury, CTCAE

Death


Factor VIII Inactivation

Presence of inactivating antibodies to factor VIII in the blood.


Peritoneal Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the peritoneum.


Grade 3 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Upper Respiratory Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Chest Pain in Sternum

The location of the chest pain is in the middle of the anterior wall of the thorax, bounded by the clavicles, above, and with the cartilages of the first seven ribs, along the sides.


Scrotal Infection

A bacterial, fungal or viral infectious process affecting the scrotum.


Tubular adenoma of breast

A benign, well circumscribed neoplasm that arises from the breast.  It is composed entirely of tubular structures that contain epithelial and myoepithelial cells.


Stage IVA Gallbladder Carcinoma

Stage IVA includes: T4, N0-1, M0. T4: Tumor invades the main portal vein or hepatic artery, or invades two or more extrahepatic organs or structures.  N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. M0: No distant metastasis.  (from AJCC 7th Ed.)


Ocular surface squamous neoplasia

An umbrella term that comprises the spectrum of squamous neoplasms of the conjunctiva, ranging  from low-grade squamous intraepithelial neoplasia to invasive conjunctival squamous cell carcinoma.


Urethritis Cystica and Glandularis

A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by urothelial cells and metaplastic glandular cells.


Grade 1 Skin Hypopigmentation, CTCAE

Hypopigmentation or depigmentation covering <10% BSA; no psychosocial impact


Grade 5 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Outer Ear Pinna Intra-Operative Injury, CTCAE


Intraocular Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that occurs in the intraocular area.


Congenital spondylolysis of lumbosacral region

A defect in the pars interarticularis of the vertebral arch of a lumbar or sacral vertebra that is present at the time of birth.


Grade 1 Bronchospasm and Wheezing, CTCAE


Chronic Phase Primary Myelofibrosis

Primary myelofibrosis characterized by the presence of less than 10% blasts in the peripheral blood or bone marrow.


Advanced NUT Carcinoma

NUT carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Immature Granulocytic Sarcoma

A granulocytic sarcoma composed of myeloblasts and promyelocytes (WHO 2001).


Foreign body in genitourinary tract

Extraneous material located within the genital and urinary organs.


Non-Neoplastic Lacrimal System Disorder

A non-neoplastic disorder that affects the lacrimal gland and/or the lacrimal drainage system.


Neonatal Rash, AE

An adverse event in a newborn characterized by an eruption in the skin which affects its appearance and/or texture.


Unresectable Fallopian Tube Carcinoma

Fallopian tube carcinoma that is not amenable to surgical resection.


Grade 4 Iron Overload, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Left Ventricular Systolic Dysfunction, CTCAE


Grade 1 Hepatitis Viral, CTCAE

Asymptomatic, intervention not indicated


Grade 3 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Locally Advanced Anal Carcinoma

Anal carcinoma that has spread to nearby tissues or lymph nodes.


Grade 1 Lung Intra-Operative Injury, CTCAE


Rectal Fistula, CTCAE

A disorder characterized by an abnormal communication between the rectum and another organ or anatomic site.


Small Intestine Infection, CTCAE

A disorder characterized by an infectious process involving the small intestine.


Mental disorder due to a general medical condition

A category of psychiatric disorders which are the direct physiologic consequence of a general medical condition.


Liver Dysplastic Nodule

A premalignant neoplastic nodular lesion of the liver that usually measures less than 15 mm.  It is found during microscopic examination of liver tissues, usually in cirrhotic livers.  Based on the degree of atypia, it is classified as low or high grade.


Grade 4 Ascites, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Pathologic Stage III Retinoblastoma AJCC v8

Stage III includes: Any pT, pN1, cM0, Any H. pN1: Regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Grade 2 Uterine Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 5 Cranial Nerve XII Neuropathy, CTCAE


Grade 1 Vaginal Infection, CTCAE

Localized, local intervention indicated


Grade 4 Injury To Superior Vena Cava, CTCAE


Stage I Uterine Corpus Cancer

Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0). T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium or invades less than one-half of the myometrium. T1b: Tumor invades one-half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Central Nervous System Dermoid Cyst

A dermoid cyst arising in the central nervous system.


Grade 2 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Intraoperative Urinary Injury, CTCAE

Partial resection of injured organ/structure indicated


Mild Chronic Inflammation

A chronic inflammatory process characterized by the accumulation of a small number of lymphocytes and plasma cells.


Hypernatremia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood.


Grade 1 Aspartate Aminotransferase Increased, CTCAE

>ULN-3.0 x ULN if baseline was normal; 1.5-3.0 x baseline if baseline was abnormal


Traumatic arthropathy

Any arthropathy that is caused by trauma.


Grade 5 Blood and Lymphatic System Disorders - Other, Specify, CTCAE

Death


Locally Advanced Pancreatic Adenocarcinoma

A pancreatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adverse Event Associated with Secondary Malignancy


Ileal Perforation, CTCAE 5.0

A disorder characterized by a rupture in the ileal wall.


Pancreatic Duct Intra-Operative Injury, CTCAE


Grade 2 Vitreous Hemorrhage, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL


Laryngeal Carcinoid Tumor

A rare, well differentiated, low grade neuroendocrine neoplasm that arises from the larynx.


Grade 5 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Anal Sphincter Intra-Operative Injury, CTCAE


Grade 1 Sleep Apnea, CTCAE

Snoring and nocturnal sleep arousal without apneic periods


Grade 4 Face NOS Intra-Operative Injury, CTCAE


Grade 2 Hearing Patients without Baseline Audiogram and Not Enrolled in a Monitoring Program, CTCAE


Grade 4 Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


Skin Ulceration, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the skin.


Grade 2 External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Advanced Neuroendocrine Neoplasm

A neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Systemic Mastocytosis Associated with Germ Cell Tumor

A disorder characterized by systemic infiltration of internal organs by aggregates of neoplastic mast cells and the presence of a co-occurring germ cell tumor.


Grade 4 Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IV Testicular Non-Seminomatous Germ Cell Tumor


Grade 2 Skin Induration, CTCAE

Moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL


Mesonephric-like adenocarcinoma

An exceedingly rare adenocarcinoma that arises from the uterine corpus and ovary and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Adult Acute Megakaryoblastic Leukemia

An acute megakaryoblastic leukemia occurring in adults.


Treatment-sensitive HIV Infection

An infection with human immunodeficiency virus that responds to therapy.


Dysphasia, CTCAE

A disorder characterized by impairment of verbal communication skills, often resulting from brain damage.


Deep Penetrating Nevus

A distinctive melanocytic nevus characterized by a sharply demarcated, circumscribed, and usually wedge-shaped configuration, with the base toward the epidermis and the tip toward the reticular dermis and subcutis. It may simulate melanoma both clinically and histologically.


Allergic Rhinitis Including Sneezing Nasal Stuffiness Postnasal Drip, CTCAE


neoplasm of basal ganglia

A benign or malignant neoplasm that affects the basal ganglia.


Grade 1 Atelectasis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Hyperlactemia

Abnormally high level of lactate in the blood.


Coagulation disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Cavernous Angioleiomyoma

A morphologic variant of angioleiomyoma characterized by the presence of markedly dilated vascular channels.


Peri-prosthetic Joint Infection

Infection around an implant following joint replacement.


Grade 3 Urinary Conduit Intra-Operative Injury, CTCAE


Grade 1 Persistent Pulmonary Hypertension of the Newborn, AE

An adverse event in a newborn characterized by technical evidence of increased right ventricular pressures; no clinical symptoms.


Adverse Event Associated with the Kidney and Genitourinary System


Grade 2 Abdominal Distension or Bloating, CTCAE


Grade 2 Nails Intra-Operative Injury, CTCAE


Renal Calculi, CTCAE

A disorder characterized by the formation of crystals/kidney stones in the pelvis of the kidney.


Other Iatrogenic Immunodeficiency-Related Lymphoproliferative Disorders

Lymphoid proliferations or lymphomas that arise in patients treated with immunosuppressive drugs for autoimmune diseases or conditions other than in the post-transplant setting. (WHO 2017)


Grade 3 Testicular Pain, CTCAE

Severe pain; limiting self care ADL


Grade 1 Neuralgia and Peripheral Nerve Pain, CTCAE


Occlusion

Obstruction or a closure of hollow organ, passageway or vessel; also the transient approximation of the edges of a natural opening; imperforation.


Clinical Course of Disease

A term that refers to the nature and/or clinical outcome of a disease (e.g., acute or chronic disease, aggressive or indolent disease, recurrent disease, etc.).


Grade 1 Pulmonary Edema, CTCAE

Radiologic findings only; minimal dyspnea on exertion


Grade 3 Creatinine Increased, CTCAE

>3.0 x baseline; >3.0-6.0 x ULN


Non-serious Adverse Event

Any adverse experience that does not meet the definition of serious. Non-serious adverse events are classified as mild, moderate and severe.


White Matter Injury

Focal areas of necrosis, with or without cysts, and diffuse areas of white matter dysmaturation with maturation arrest of the pre-oligodendroglia cells, located in the cerebral white matter.


Gastric Hodgkin's Lymphoma

An extremely rare Hodgkin lymphoma that arises from the stomach.


Amnesia, CTCAE

A disorder characterized by systematic and extensive loss of memory.


Cervical high grade squamous intraepithelial lesion

A precancerous neoplastic process that affects the cervical squamous epithelium. It is usually associated with human papillomavirus infection. It is classified as cervical squamous intraepithelial neoplasia 2 when there is nuclear atypia in both the upper and lower epithelial layers, mitotic figures are confined to the basal two-thirds of the epithelium, and maturation is present in the upper half of the epithelium. It is classified as cervical squamous intraepithelial neoplasia 3 when there is nuclear atypia and mitotic figures throughout the entire thickness of the epithelium, and maturation is absent or confined to the upper third of the epithelium.


Grade 5 Infusion Related Reaction, CTCAE

Death


Pathologic Stage II Esophageal Adenocarcinoma AJCC v8

Stage II includes: IIA: (T2, N0, M0, G3); (T2, N0, M0, GX); IIB: (T1, N1, M0, Any G); (T3, N0, M0, Any G). T2: Tumor invades the muscularis propria. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


A meningioma that arises within the cranial cavity and results from exposure to radiation.


Astrocytoma, IDH-Wildtype

Astrocytoma lacking mutations in IDH1 or IDH2 genes. It includes diffuse astrocytoma, IDH-wildtype and anaplastic astrocytoma, IDH-wildtype.


Grade 3 Neonatal Intraventricular Hemorrhage, AE

An adverse event in a newborn characterized by hemorrhage occupying greater than 50% of the ventricle volume; ventricular dilatation greater than 4mm above the 97th percentile; parenchymal venous infarction; requiring temporizing neurosurgical procedure (drain, shunt or reservoir).


Grade 4 Hallucinations, CTCAE

Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Stage IA Ampulla of Vater Cancer AJCC v7

Stage IA includes: T1, N0, M0. T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Locally Advanced Malignant Skin Neoplasm

A malignant neoplasm of the skin that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Fallopian Tube Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 2 Mucosal Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 4 Pericardial Tamponade, CTCAE

Life-threatening consequences; urgent intervention indicated


Myolipoma

A benign extrauterine tumor composed of mature adipocytes and smooth muscle cells.


Glandular odontogenic cyst

A developmental odontogenic cyst with epithelial features that simulate salivary gland or glandular differentiation. (WHO 2017)


Stage IIIA Merkel Cell Carcinoma AJCC v7

Stage IIIA includes: Any T, N1a, M0.  N1a: Micrometastasis in regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th Ed.)


Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 2 Epistaxis, CTCAE

Moderate symptoms; medical intervention indicated (e.g., nasal packing, cauterization; topical vasoconstrictors)


Grade 1 Intraoperative Ocular Injury, CTCAE

Primary repair of injured organ/structure indicated


FIGO Stage IVB Gestational Trophoblastic Tumor


Benign Thalamic Neoplasm

A benign neoplasm of the thalamus.


Grade 5 Tracheal Mucositis, CTCAE

Death


Grade 3 Guillain-Barre Syndrome, CTCAE

Severe symptoms; limiting self care ADL


Nodular and Massive Retinal Gliosis

A spectrum of discrete retinal glial proliferations surrounding blood vessels, ranging in size from small nodules to massive lesions that fill the eye. (WHO 2018)


Conventional Schwannoma

A common, usually encapsulated benign nerve sheath tumor composed of well-differentiated Schwann cells.


Borderline Broad Ligament Serous Tumor

A rare non-invasive tumor that arises from the broad ligament. It is characterized by the presence of serous epithelial cell proliferation and cytological atypia.


Lymphosarcoma of spleen

An antiquated term that refers to a non-Hodgkin lymphoma composed of small and medium sized lymphocytes affecting the spleen.


Grade 3 Myocardial Infarction, CTCAE

Severe symptoms; cardiac enzymes abnormal; hemodynamically stable; ECG changes consistent with infarction


Grade 4 Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic Digestive System Neuroendocrine Neoplasm

A neuroendocrine neoplasm that arises from any part of the digestive system and has metastasized to another anatomic site.


Ache

A dull persistent (usually moderately intense) pain.


Thrombotic Disorder

A disorder in which there is pathological development of blood clots within the cardiovascular system.


Primary cutaneous acral CD8 positive T-cell lymphoma

A cutaneous T-cell lymphoma presenting as an acral (peripheral) lesion. It was originally described as originating in the ear and is usually localized to a single site. It is composed of CD8-positive neoplastic T-lymphocytes. It has an indolent clinical course.


Vaginal Hemorrhage, CTCAE

A disorder characterized by bleeding from the vagina.


Grade 3 Joint Intra-Operative Injury, CTCAE


Grade 5 Urinary Tract Infection, CTCAE

Death


Grade 2 Ileum Stricture or Stenosis, CTCAE


Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Secondary Glioblastoma

A glioblastoma arising from a lower grade astrocytoma.


Grade 3 Cholesterol High, CTCAE

>400-500 mg/dL; >10.34-12.92 mmol/L


Grade 4 Leukemia Secondary To Oncology Chemotherapy, CTCAE

Present


A lymphoproliferative disorder that occurs in a patient with immunodeficiency.


Recurrent Malignant Glioma

The reemergence of malignant glioma after a period of remission.


Grade 2 Outer Ear Pinna Intra-Operative Injury, CTCAE


Grade 1 Skin Intra-Operative Injury, CTCAE


AIDS-Related Hodgkin Lymphoma

Hodgkin lymphoma secondary to AIDS. An increased incidence of Hodgkin lymphomas has been observed in HIV positive patients. Most cases are morphologically classified as lymphocyte depleted or mixed cellularity Hodgkin lymphomas.


Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Solar Radiation-Related Malignant Neoplasm

A malignant neoplasm arising in an anatomic site exposed to solar radiation.


Grade 2 Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Cranial Nerve VI Neuropathy, CTCAE


Grade 3 Pleura Intra-Operative Injury, CTCAE


Grade 3 Carotid Artery Intra-Operative Injury, CTCAE


Grade 1 Mediastinum Intra-Operative Injury, CTCAE


Basal cell hyperplasia

A pathologic hyperplastic process characterized by the proliferation of the cells of the epithelial layer that resemble the basal cells of the lower part of the epidermis.


PSA 50 Percent or Greater than Nadir

A finding indicating that the blood concentration of prostate specific antigen in a subject's sample has increased by 50 percent or more over the lowest value recorded for a sample from that subject.


Multilocular Thymic Cyst

A multicystic lesion that arises from the epithelial component of the thymus gland.  It is usually associated with the presence of lymphoid follicles and degenerative changes.  Although its etiology is unknown, it has been described in patients with HIV infection and in patients with nodular sclerosis Hodgkin lymphoma affecting the thymus gland.


Extra-adrenal paraganglioma, malignant

An extra-adrenal paraganglioma that metastasizes to regional or distant anatomic sites.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


Adult Myofibroma

A rare myofibroma that occurs in adults.


Grade 3 Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Cholecystitis, CTCAE

Symptomatic; medical intervention indicated


Grade 5 Larynx Obstruction and Stenosis, CTCAE


Grade 4 Thoracic Duct Intra-Operative Injury, CTCAE


Otitis Externa, CTCAE

A disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage.


Subcutaneous edema

Presence of edema in subcutaneous connective tissue.


Grade 2 Ileal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Unresectable Abdominal Neuroendocrine Neoplasm

An abdominal neuroendocrine neoplasm that is not amenable to surgical resection.


Grade 4 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


BCOR-CCNB3 Sarcoma

A group of rare primitive round cell sarcomas characterized by the presence of BCOR-CCNB3 fusion gene.


Grade 2 Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


AIDS-Related Lymphoma by Working Formulation


Lugano Classification Stage II Bulky Hodgkin Lymphoma AJCC v8

Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Grade 3 Reduction in Growth Velocity, CTCAE


Non-Neoplastic Urethra Disorder

A non-neoplastic disorder affecting the urethra.


Recurrent Spindle Cell Sarcoma

The reemergence of spindle cell sarcoma after a period of remission.


Grade 1 Periventricular Leukomalacia, AE

An adverse event in a newborn characterized by transient periventricular echodensities persisting greater than seven days and resolving completely.


Grade 3 Esophagus Intra-Operative Injury, CTCAE


Ankle Fracture, CTCAE

A finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot.


Recurrent Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

The reemergence of acute myeloid leukemia with recurrent genetic abnormalities after a period of remission.


Usual Prostate Adenocarcinoma with Neuroendocrine Differentiation

Acinar adenocarcinoma of the prostate gland characterized by the presence of scattered neuroendocrine cells by immunohistochemistry.


Grade 5 Colonic Perforation, CTCAE

Death


Grade 2 Disseminated Intravascular Coagulation, CTCAE

Laboratory findings with no bleeding


Grade 3 Ear Pain, CTCAE

Severe pain; limiting self care ADL


Benign neoplasm of broad ligament

A non-metastasizing neoplasm that arises from the broad ligament.


Serous Endometrial Intraepithelial Carcinoma

A precursor of endometrial serous adenocarcinoma characterized by the replacement of the normal endometrial cells by malignant glandular cells that resemble the malignant cells of invasive serous adenocarcinoma. The endometrial neoplastic process is non-invasive. It may coexist with invasive endometrial adenocarcinoma or can be associated with metastases outside the uterus, in the absence of invasive endometrial carcinoma.


Grade 5 Neck Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Arrhythmia-Induced Cardiomyopathy

A reversible cardiomyopathy presumed to result from the presence of arrhythmias, including the tachycardia-induced cardiomyopathy (T-CM), atrial fibrillation-induced cardiomyopathy (AF-CM), and premature ventricular contraction-induced cardiomyopathy (PVC-CM).


Grade 1 Salivary Gland Fistula, CTCAE

Asymptomatic


Stage IIA Prostate Cancer AJCC v7

Stage IIA includes: (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X). T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  (AJCC 7th ed.)


Grade 3 Electrocardiogram QT Corrected Interval Prolonged, CTCAE

Average QTc >= 501 ms; >60 ms change from baseline


Injury of prostate

Trauma to the prostate.


Refractory Digestive System Neuroendocrine Neoplasm

A digestive system neuroendocrine neoplasm that is resistant to treatment.


Corneal Infection, CTCAE

A disorder characterized by an infectious process involving the cornea.


Grade 3 Small Intestine Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Gastrointestinal Radiation Injury

Radiation injury of the gastrointestinal system.


Grade 1 Uterine Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 3 Other Constitutional Symptoms, CTCAE


Severe Sepsis

Clinical syndrome defined by the presence of both infection and a systemic inflammatory response that progresses to multi-organ failure.


Thoracoceloschisis

A congenital fissure of both the thoracic and abdominal walls.


Grade 2 Depression, CTCAE

Moderate depressive symptoms; limiting instrumental ADL


In situ mantle cell neoplasia

A neoplastic lymphoid process characterized by the presence of cyclin D1 positive lymphoid cells, typically in the inner mantle zones of lymphoid tissue follicles, in cases that do not suggest the diagnosis of a mantle cell lymphoma. It is often found incidentally and has a low rate of progression.


Bronchial Fistula, CTCAE

A disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site.


Clinical Stage IV Esophageal Adenocarcinoma AJCC v8

Stage IV includes: IVA: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Testicular Disorder, CTCAE

A disorder characterized by abnormal function or appearance of the testis.


Small cell carcinoma, fusiform cell

A neuroendocrine carcinoma composed of malignant fusiform small cells.


Recurrent Endocervical Adenocarcinoma, Usual-Type

The reemergence of endocervical adenocarcinoma, usual-type after a period of remission.


Grade 3 Urinary Incontinence, CTCAE

Intervention indicated (e.g., clamp, collagen injections); operative intervention indicated; limiting self care ADL


Stage III Renal Pelvis and Ureter Cancer AJCC v8

Stage III includes: T3, N0, M0. T3: For renal pelvis only: Tumor invades beyond muscularis into peripelvic fat or into the renal parenchyma. For ureter only: Tumor invades beyond muscularis into periureteric fat. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Peritoneal Cavity Intra-Operative Injury, CTCAE


Bile Duct Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the bile duct.


Grade 4 Electrocardiogram QT Corrected Interval Prolonged, CTCAE

Torsade de pointes; polymorphic ventricular tachycardia; signs/symptoms of serious arrhythmia


Grade 5 Jejunal Perforation, CTCAE

Death


Grade 3 Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Enterocolitis, CTCAE

Life-threatening consequences; urgent intervention indicated


mucinous cystic neoplasm with moderate dysplasia

A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of moderate dysplasia.  The neoplastic columnar mucin-producing epithelial cells form papillary projections or crypt-like invaginations. There is cellular pseudostratification and mitotic activity present.


Hindgut Neuroendocrine Tumor G1

A carcinoid tumor that arises from the sigmoid colon,descending colon, or rectum.


Stage IA Osteosarcoma AJCC v7

Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 5 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Chronic Leukemia

The reemergence of chronic leukemia after a period of remission.


Gallbladder Fistula, CTCAE

A disorder characterized by an abnormal communication between the gallbladder and another organ or anatomic site.


Grade 5 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Filiform Serrated Adenoma

A traditional serrated adenoma characterized by the presence of prominent villous projections of the neoplastic epithelium.


Grade 3 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Gastrointestinal Stoma Intra-Operative Injury, CTCAE


Grade 4 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Mild epithelial dysplasia

A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. It is characterized by the presence of mild epithelial dysplasia.


Grade 3 Alanine Aminotransferase Increased, CTCAE

>5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


Non-Neoplastic Cardiovascular Disorder

A non-neoplastic disorder that affects the heart and/or vessels.  Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema.


Locally Advanced Bladder Urothelial Carcinoma

A bladder urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Intestinal Stoma Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 3 Duodenal Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Grade 5 Infantile Apnea, AE

An apneic adverse event in a newborn which results in death.


Grade 3 Fatigue, CTCAE

Fatigue not relieved by rest, limiting self care ADL


Chronic acquired lymphedema

A condition that is caused by trauma to the lymph system, which disrupts the normal flow of lymph fluid. This is most often due to surgery that requires lymph node removal or a large amount of lymph tissue. This disruption is especially apparent if the lymph nodes under the arm and arm and around the breast are compromised due to breast cancer surgery, diagnostic dissection, mastectomy, or radiation.


Grade 5 Neonatal Spontaneous Intestinal Perforation, AE

A spontaneous intestinal perforation (SIP) adverse event in a newborn which results in death.


Grade 3 Central Nervous System Necrosis, CTCAE

Severe symptoms; medical intervention indicated


Grade 5 Otitis Externa, CTCAE

Death


Grade 2 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Prolapse of Urostomy, CTCAE

Life-threatening consequences; urgent intervention indicated


Abdominal Infection, CTCAE

A disorder characterized by an infectious process involving the abdominal cavity.


Chest Pain Along Right Middle Sternal Border

The location of the chest pain is along the right middle border of the sternum.


Acute Myeloid Leukemia with Gene Mutations

A term referring to acute myeloid leukemias associated with gene mutations most often of the FLT3, NPM1, and CEBPA genes. These leukemias may have normal karyotypes or additional chromosomal aberrations.


General Disorders and Administration Site Conditions, CTCAE


Testicular Sertoli Cell Tumor, Lipid Rich Variant

A testicular Sertoli cell tumor in which the neoplastic cells have clear and vacuolated cytoplasm due to accumulation of intracytoplasmic lipids.


Grade 2 Dyspnea, CTCAE

Shortness of breath with minimal exertion; limiting instrumental ADL


Endometrial Dedifferentiated Carcinoma

A carcinoma that arises from the endometrium and is characterized by the presence of an undifferentiated carcinomatous component and a second component of either FIGO grade 1 or 2 endometrioid carcinoma.


Adult Type Granulosa Cell Tumor

A granulosa cell tumor occurring in the ovary and rarely in the testis. It is composed of granulosa cells in an often fibrothecomatous stroma. The neoplastic cells may form various patterns including the microfollicular, which is characterized by the presence of Call-Exner bodies, macrofollicular, insular, trabecular, and diffuse pattern. In females, it affects middle aged to post-menopausal women. Signs and symptoms include abdominal mass, hemoperitoneum, and ascites. Estrogenic and rarely androgenic manifestations may be present. The vast majority of cases present as stage I tumors; however, all tumors have a potential for aggressive clinical course. In males, it is reported in the age range of 16-76 years and the average age at presentation is 44 years. A minority of patients have gynecomastia. Metastases have been reported in a minority of patients.


Grade 2 Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


Grade 2 Tooth Development Disorder, CTCAE

Impairment correctable with oral surgery


Stage IA2 Cervical Cancer FIGO 2009

Cervical carcinoma measuring more than 3 mm and not more than 5 mm in depth. (FIGO 2009)


Grade 3 Lip Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Cranial Nerve X Intra-Operative Injury, CTCAE


Grade 5 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


A1 Hydronephrosis

Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of 4 to less than 7 mm at less than 28 weeks, 2) to less than10 mm at greater than or equal to 28 weeks, and 3) may have central calyceal dilation. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Grade 2 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Cecal Hemorrhage, CTCAE

Death


Grade 2 Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Pulmonary Valve Disease, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)


Grade 4 Tracheal Stenosis, CTCAE

Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Grade 2 Hepatic Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 4 Portal Vein Intra-Operative Injury, CTCAE


Fourth Degree Perineal Laceration

Injury to perineum involving anal sphincter complex and internal anal sphincter and anal epithelium. (reVITALize)


Sickle Cell-SS Disease

A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles.


Steroid-induced myopathy

A non-neoplastic disorder affecting the skeletal muscles. It is caused by damage to muscle fibers either by excessive intake of corticosteroids (steroid treatment) or high levels of endogenous corticosteroids due to hormonal abnormalities. Patients usually present with weakness mainly in the proximal muscles of the upper and lower extremities and the neck flexors.


Grade 3 Upper Extremity Intra-Operative Injury, CTCAE


Grade 1 Left Ventricular Systolic Dysfunction, CTCAE


Grade 3 Small Intestine Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated; limiting self care ADL


Neonatal Early-Onset Sepsis

An infectious disorder of newborn infants that is characterized by a systemic inflammatory response within 72 hours of life and is most commonly caused by bacteria.


Grade 1 Gastrointestinal Stoma Leak, CTCAE


Grade 3 Diarrhea, CTCAE

Increase of >=7 stools per day over baseline; hospitalization indicated; severe increase in ostomy output compared to baseline; limiting self care ADL


Grade 1 Hypoxic Ischemic Encephalopathy, AE

An adverse event in a newborn clinically classified as perinatal asphyxia, but not resulting in encephalopathy.


Refractory Cervical Carcinoma

Cervical carcinoma that is resistant to treatment.


Grade 5 Rectal Obstruction, CTCAE

Death


Intrahepatic Bile Duct Biliary Intraepithelial Neoplasia

A neoplastic, non-invasive lesion that affects the intrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Grade 3 Intra-Abdominal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Idiopathic 46,XY Differences of Sex Development

Conditions affecting individuals whose karyotype is 46,XY that is characterized by atypical development of the internal or external sex structures, or the gonads, and in whom no genetic, environmental, or biochemical causation can be established.


Stage IIB Ampulla of Vater Cancer AJCC v7

Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades the duodenal wall.  T3: Tumor invades the pancreas.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Islet Glucagon Cell Hyperplasia

Hyperplasia of the alpha cells of the pancreas.


Grade 3 Cardiac Troponin T Increased, CTCAE

Levels consistent with myocardial infarction as defined by the manufacturer


Malignant neoplasm of urethra local

A malignant neoplasm of the urethra that has not spread to other regions.


Unresectable Pancreatic Neuroendocrine Carcinoma

Pancreatic neuroendocrine carcinoma that is not amenable to surgical resection.


Mucosal Melanoma of the Urinary System

A malignant melanocytic neoplasm that arises from a mucosal site of the urinary system.


Exogenous Obesity

Obesity caused by caloric intake greater than caloric expenditures.


Recurrent Extracranial Malignant Solid Neoplasm

The reemergence of an extracranial malignant solid neoplasm after a period of remission.


Proctitis, CTCAE

A disorder characterized by inflammation of the rectum.


Aleukemic Acute Lymphoblastic Leukemia Cutis

Aleukemic leukemia cutis where the skin in infiltrated by lymphoblasts.


Grade 3 Cognitive Disturbance, CTCAE

Severe cognitive disability; significant impairment of work/school/life performance


HPV16 Infection

An infection caused by human papillomavirus 16. HPV16 infection is associated with a risk for cervical cancer.


Grade 5 Neonatal Rash, AE

A rash adverse event in a newborn which results in death.


Hemangioma of conjunctiva

A hemangioma that arises from the conjunctiva.


Neonatal Spontaneous Intestinal Perforation, AE

An adverse event in a newborn characterized by a perforation in the gastrointestinal tract of a newborn with no demonstrable cause.


Grade 2 Vein NOS Intra-Operative Injury, CTCAE


Grade 4 Intraoperative Neurological Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Esophageal Varices Hemorrhage, CTCAE 5.0

A disorder characterized by bleeding from esophageal varices.


Grade 1 Confusion, CTCAE

Mild disorientation


Exertional Fatigue

Prolonged, extreme exhaustion after physical or mental effort or stress.


Grade 1 Feminization Acquired, CTCAE

Mild symptoms; intervention not indicated


Refractory Gallbladder Carcinoma

Gallbladder carcinoma that is resistant to treatment.


Ileal Fistula

An abnormal communication between the ileum and another organ or cavity.


Vulvar Non-Neoplastic Disorder

A non-neoplastic disorder that affects the vulva. Representative examples include infection and fibroepithelial polyp.


Recurrent Laryngeal Nerve Palsy, CTCAE

A disorder characterized by paralysis of the recurrent laryngeal nerve.


Grade 4 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


External hydrocephalus

Abnormal increase of cerebrospinal fluid in the subdural space of the brain.


Grade 2 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 3 Gastric Fistula, CTCAE

Invasive intervention indicated


A Hodgkin lymphoma that develops in patients who are immunosuppressed with methotrexate.


Adult Diffuse Mixed Cell Lymphoma

A B-or T-cell non-Hodgkin lymphoma composed of a mixed-sized lymphocytic population occurring in adults.


Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Esophageal Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus.  It is characterized by the presence of malignant large cells.


Grade 3 Tendon Reflex Decreased, CTCAE

Absence of all reflexes


Grade 2 Hypotension, CTCAE

Non-urgent medical intervention indicated


Grade 1 Edema Limbs, CTCAE

5-10% inter-limb discrepancy in volume or circumference at point of greatest visible difference; swelling or obscuration of anatomic architecture on close inspection


Flu Like Symptoms, CTCAE

A disorder characterized by a group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite and dry cough.


Recurrent Subsequent Malignant Neoplasm

The reemergence of a malignant neoplasm other than the original one, after a period of remission.


Grade 4 Neuroendocrine ADH Secretion Abnormality, CTCAE


Stage IVA Esophageal Squamous Cell Carcinoma


Grade 1 Obstruction Gastric, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Muscle Weakness Left-Sided, CTCAE

A disorder characterized by a reduction in the strength of the muscles on the left side of the body.


Grade 5 Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Eye Melanocytoma

A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve or the uvea.


Grade 3 Intraoperative Urinary Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


tubular adenoma of gallbladder

An adenoma that arises from the gallbladder.  It is characterized by the presence of a tubular growth pattern.


End Organ Damage from Diabetes

Irreparable damage to multiple organs/systems which is the result of chronic complications of diabetes.  The affected organs/systems include the cardiovascular system, kidneys, eyes, nervous system, joints and feet.


Grade 4 Dental and Teeth and Peridontal Pain, CTCAE


Grade 5 Neonatal Culture Negative Sepsis, AE

A culture negative neonatal sepsis adverse event in a newborn which results in death.


Human Papillomavirus-Related Cervical Carcinoma

A carcinoma that arises from the cervix and is caused by human papillomavirus infection.


Stage IV Uterine Corpus Cancer AJCC v6

Stage IV includes: IVA: (T4, Any N, M0); IVB: (Any T, Any N, M1).  T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M1: Distant metastasis (includes metastasis to abdominal lymph nodes other than para-aortic, and/or inguinal lymph nodes: excludes metastasis to vagina, pelvic serosa, or adnexa). (AJCC 6th ed.)


Grade 4 Pharyngeal Mucositis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Sinus Tachycardia, CTCAE

Urgent medical intervention indicated


Oligometastatic Gastric Adenocarcinoma

Gastric adenocarcinoma that has metastasized to a limited number of sites.


Grade 3 Cystitis Noninfective, CTCAE

Gross hematuria; transfusion, IV medications, or hospitalization indicated; elective invasive intervention indicated


Grade 3 Irritability in Children Less Than 3 Years of Age, CTCAE