Subgaleal haematoma

A collection of blood between the scalp and the skull periosteum.


Grade 5 Viscera Vein Injury, CTCAE

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Naso-palatine duct cyst

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A non-odontogenic cyst of developmental origin that arises in the midline of the anterior maxilla. It is found exclusively in the midline of the anterior hard palate. (WHO 2017)


Absent Adverse Event

The absence of adverse events or within normal limits or values.


Grade 5 Bronchospasm and Wheezing, CTCAE


Grade 4 Pharyngeal Stenosis, CTCAE

Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Unresectable Glioblastoma

A glioblastoma that is not amenable to surgical resection.


Grade 3 Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malignant lymphoma, diffuse

An antiquated term referring to non-Hodgkin lymphomas with a diffuse architectural pattern.


Neonatal Bradyarrhythmia, AE

An adverse event in a newborn characterized by non-sinus rhythm with an abnormally low heart rate for age.


Grade 5 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Retinopathy of Prematurity with Plus Disease

A stage of retinopathy of prematurity characterized by the presence of the following in at least two quadrants around the optic nerve: dilation and tortuosity of major retinal vasculature as a result of increased blood flow.


Grade 2 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Fallopian Tube Perforation, CTCAE 5.0

A disorder characterized by a rupture of the fallopian tube wall.


Ampulla of Vater Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

A rare variant of undifferentiated carcinoma that arises from the ampulla of Vater. It is characterized by the presence of non-neoplastic, histiocytic, osteoclast-like multinucleated giant cells.


High-Grade Squamous Intraepithelial Lesions

A precancerous neoplastic process characterized by the presence of moderate or severe dysplastic cytological changes which extend to the upper part of the squamous epithelium.  Maturation at the surface of the squamous epithelium may or may not be present.  Representative examples include the high grade esophageal squamous intraepithelial neoplasia, high grade cervical squamous intraepithelial neoplasia, high grade vaginal intraepithelial neoplasia, and high grade vulvar intraepithelial neoplasia.


Grade 2 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Voice Alteration, CTCAE

Mild or intermittent change from normal voice


Grade 5 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Solar Radiation-Related Skin Squamous Cell Carcinoma

A squamous cell carcinoma arising in a skin site exposed to solar radiation.


Locally Advanced Malignant Solid Neoplasm

A malignant solid neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Sexually Transmitted Chlamydial Disease

A chlamydial infection that was sexually transmitted.


Grade 1 Penile Pain, CTCAE

Mild pain


Recurrent Malignant Genitourinary System Neoplasm

The reemergence of a malignant genitourinary system neoplasm after a period of remission.


Intracranial Hemorrhage, CTCAE

A disorder characterized by bleeding from the cranium.


Unresectable Gastric Adenocarcinoma

A gastric adenocarcinoma that is not amenable to surgical resection.


Grade 4 Urinary Tract Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Weight Gain, CTCAE

10-<20% from baseline


Enteropathogenic E coli Infection

A pathotype of Escherichia coli, which is a gram-negative bacteria that is transmitted through the fecal-oral route. It has an incubation period of 9-12 hours and a duration of 12 days. Symptoms may include persistent severe acute diarrhea.


Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Biliary Fistula

An abnormal communication between the bile ducts and another organ or cavity.


Spindle Cell/Pleomorphic Lipoma

A benign lipomatous neoplasm characterized by the presence of an admixture of mature adipose tissue and bland spindle cells.  The pleomorphic variant contains in addition multinucleated giant cells.  It usually arises in the neck and upper trunk in older males.


Grade 5 Urinary Fistula, CTCAE

Death


Grade 2 Bronchial Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Stage IIIC1 Uterine Corpus Cancer AJCC v7

Stage IIIC1 includes: T1-T3, N1, M0.  T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. N1: Regional lymph node metastasis to pelvic lymph nodes. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Grade 2 Dysphasia, CTCAE

Moderate receptive or expressive characteristics; impairing ability to communicate spontaneously


Grade 2 Pancreatic Duct Intra-Operative Injury, CTCAE


Stage II Skin Cancer

Stage II includes: T2, N0, M0.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness; Clark level equal or greater than IV; and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


Grade 2 Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Ureter Intra-Operative Injury, CTCAE


Grade 1 Bone Growth Limb Length Discrepancy, CTCAE


Leakage

The unintentional discharge of a substance from a container or enclosed space.


Grade 4 Skin Ulceration, CTCAE

Any size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss


Refractory Pseudomyxoma Peritonei

Pseudomyxoma peritonei that is resistant to treatment.


Condylomatous carcinoma

A squamous cell carcinoma characterized by a papillary growth pattern, hyperkeratosis, and koilocytosis.


Advanced Glioblastoma

Glioblastoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Recurrent Laryngeal Nerve Palsy, CTCAE


Grade 3 Bladder Perforation, CTCAE

Invasive intervention indicated


Corn of toe

A thickening of the skin due to friction or pressure which results in the formation of a small, painful, raised bump associated with a conical mass pointing down into the dermis.


Grade 3 Non-Infectious Wound Complication, CTCAE


Grade 5 Dental-Tooth Infection with Unknown Absolute Neutrophil Count, CTCAE


Stomal Ulcer, CTCAE 5.0

A disorder characterized by a circumscribed, erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure.


Grade 5 Fallopian Tube Perforation, CTCAE

Death


Grade 1 Bladder Intra-Operative Injury, CTCAE


K ATP Channel-Associated Diabetes Mellitus

Diabetes mellitus caused by activating mutation(s) in genes (KNCJ11 and/or ABCC8) encoding either of the 2 proteins (Kir6.2 and/or SUR1) that make up the pancreatic beta cell adenosine triphosphate-sensitive potassium channel, which is crucial for the regulation of glucose-induced insulin secretion.


Grade 1 Prostatic Pain, CTCAE

Mild pain


Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8

Stage IIIA includes: (T1, N2, M0, Any G); (T2, N1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Jejunal Ulcer, CTCAE

Symptomatic; altered GI function


Recurrent Malignant Choroid Plexus Neoplasm

The reemergence of a malignant choroid plexus neoplasm after a period of remission.


Grade 2 Gingival Pain, CTCAE

Moderate pain interfering with oral intake


Extrahepatic Bile Duct Biliary Intraepithelial Neoplasia

A neoplastic, non-invasive lesion that affects the extrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Grade 3 Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


Regressed germ cell tumor

A testicular germ cell tumor that has undergone either partial or complete regression, resulting in the creation of a fibrotic nodule in the testis.


Grade 3 Sacral Plexus Intra-Operative Injury, CTCAE


AIDS-Related Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease

Diffuse large B-cell lymphoma arising in HHV8-positive multicentric Castleman disease occurring in HIV-positive patients.


Vulvar Squamous Cell Carcinoma with Tumor Giant Cells

An aggressive squamous cell carcinoma that arises from the vulva and is characterized by the prominence of malignant giant cells.


Neoplasms, Therapy-Associated

The development of a neoplasm in response to medical or surgical treatment, induced by the treatment itself.


Grade 4 Trachea Intra-Operative Injury, CTCAE


Prevertebral Abscess

An abscess that develops in the tissues within the prevertebral fascia.


Unresectable Esophageal Adenocarcinoma

Esophageal adenocarcinoma that is not amenable to surgical resection.


Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage II Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 3 Acute Kidney Injury, CTCAE

Hospitalization indicated


Grade 4 Stomach Intra-Operative Injury, CTCAE


Grade 3 Stomach Stricture or Stenosis, CTCAE


Non-Severe Aplastic Anemia

Aplastic anemia that is characterized by bone marrow cellularity less than 30% and does not meet criteria for severe aplastic anemia.


Acquired Bilateral Cataracts

Cataracts in both eyes that result from the aging process, an injury, or as a manifestation of a systemic disorder.


Grade 1 Hypoparathyroidism, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Aorta Artery Intra-Operative Injury, CTCAE


Grade 2 Hypokalemia, CTCAE

Symptomatic with <LLN-3.0 mmol/L; intervention indicated


Grade 3 Neuroendocrine ADH Secretion Abnormality, CTCAE


Gastric Fistula

An abnormal communication between the stomach and another organ or anatomic site.


Diabetes mellitus without complication

Diabetes mellitus that does not show any evidence of tissue or organ damage.


Tooth Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IA Ampulla of Vater Cancer AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Pancreatic Fistula, CTCAE

Death


Elevated Choriogonadotropin Subunit Beta

A finding indicating elevated concentrations of human chorionicgonadotropin subunit beta in a sample.


Advanced Sarcoma of the Extremity

A sarcoma of the soft tissues or bones of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Appendicitis Perforated, CTCAE

Medical intervention indicated; operative intervention indicated


Productive Cough, CTCAE

A disorder characterized by expectorated secretions upon coughing.


Grade 1 Other Renal or Genitourinary, CTCAE


Grade 4 Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE


Serous Tubal Intraepithelial Carcinoma

A non-invasive serous carcinoma arising from the fallopian tube.


Birth Injuries

An injury sustained to a neonate during the birthing process.


Age-Related Clonal Hematopoiesis

The gradual, clonal expansion of hematopoietic stem and progenitor cells carrying specific, disruptive, and recurrent genetic variants, in individuals without clear diagnosis of hematological malignancies. It is associated with an increased risk of developing hematologic cancers.


Secondary Cerebral Hodgkin Lymphoma

A Hodgkin lymphoma that has spread to the cerebral hemisphere following the initial presentation in another nodal or extranodal site.


Grade 4 Rectum Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Lesion

A localized pathological or traumatic structural change, damage, deformity, or discontinuity of tissue, organ, or body part.


Grade 3 Injury To Carotid Artery, CTCAE

Severe symptoms; limiting self care ADL (e.g., transient cerebral ischemia); repair or revision indicated


Borderline Peritoneal Serous Tumor

A serous epithelial tumor that arises from the peritoneum and histologically resembles the serous borderline tumors that arise from the ovary.


Depletion of mitochondrial DNA

A genetically heterogenous group of disorders characterized by low mitochondrial DNA in specific tissues resulting in impaired energy production.


Grade 4 Neonatal Culture Positive Sepsis, AE

A culture positive sepsis adverse event in a newborn characterized by life-threatening consequences (e. g. shock, disseminated intravascular coagulation (DIC)); urgent major care change required.


Grade 3 Bronchial Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Pathologic Stage IIC Cutaneous Melanoma AJCC v8

Stage IIC includes: T4b, N0, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Muscle Weakness Right-Sided, CTCAE

A disorder characterized by a reduction in the strength of the muscles on the right side of the body.


Metastatic malignant neoplasm to urethra

A malignant neoplasm that has spread to the urethra from another anatomic site.


Grade 2 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Nasal Congestion, CTCAE

Associated with bloody nasal discharge or epistaxis


Inflammatory Hepatocellular Adenoma

A hepatocellular adenoma that occurs more often in women.  It is characterized by increased levels of inflammation-associated proteins.  It is usually associated with steatosis and obesity.


Grade 2 Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Elevated Type I Collagen Cross-Linked N-Telopeptide

A laboratory test result indicating the presence of an increased level of the bone resorption marker type I collagen cross-linked N-telopeptide (NTx or NTxI) in a biological sample.


Marrow Toxic Injury

An injury to the bone marrow resulting from exposure to high levels of ionizing radiation or exposure to other hazardous material.


Non-Obstructed Megaureter

A megaureter in which there is no obstruction at the ureterovesical junction.


Refractory Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma that is resistant to treatment.


Stage III Uterine Corpus Cancer AJCC v8

Stage III includes: T3, N0, M0. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Disordered Thinking

Incoherent, disorganized or illogical thought processes.


Unresectable Anal Canal Squamous Cell Carcinoma

Anal canal squamous cell carcinoma that is not amenable to surgery.


Urinary System Carcinoma

A malignant neoplasm that arises from the epithelium of any part of the urinary system. Representative examples include kidney carcinoma and bladder carcinoma.


Recto-Vesico-Vaginal Fistula

An abnormal communication between the rectum, bladder, and vagina.


Chest Pain Along Right Lower Sternal Border

The location of the chest pain is along the right lower border of the sternum.


Grade 3 Laryngeal Mucositis, CTCAE

Severe pain; severely altered eating/swallowing; medical intervention indicated


Broad Ligament Serous Adenofibroma

A rare serous adenofibroma arising from the broad ligament.


Neck Edema, CTCAE

A disorder characterized by swelling due to an accumulation of excessive fluid in the neck.


Grade 1 Depressed Level of Consciousness, CTCAE

Decreased level of alertness


Acute Respiratory Distress

An abrupt onset of signs or symptoms indicating difficulty breathing including alterations in breath sounds and rate, chest retractions and color changes.


Esophageal Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the contents in the esophagus.


Grade 3 Pleural Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


An adenocarcinoma associated with the presence of human papillomavirus infection.


Non-Myocardial Visceral Arterial Ischemia, CTCAE


Grade 4 Urinary Conduit Intra-Operative Injury, CTCAE


Grade 2 Wound Dehiscence, CTCAE

Incisional separation, local care (e.g., suturing) or medical intervention indicated (e.g., analgesic)


Grade 4 Neonatal Constipation, AE

A constipation adverse event in a newborn characterized by life-threatening consequences.


Recurrent Primary Cutaneous Lymphoma

The reemergence of primary cutaneous lymphoma after a period of remission.


Grade 4 Keratitis, CTCAE

Perforation; best corrected visual acuity of 20/200 or worse in the affected eye


Grade 2 Guillain-Barre Syndrome, CTCAE

Moderate symptoms; limiting instrumental ADL


Asymptomatic Infections

Infection associated with no detectable symptoms but caused by microorganisms capable of producing easily recognizable diseases, such a poliomyelitis or mumps.


Serum IgM Monoclonal Gammopathy of Less than 30g/L

An abnormal laboratory test result indicating that a serum IgM paraprotein concentration is less than 30g/L.


Grade 5 Laryngopharyngeal Dysesthesia, CTCAE

Death


Stage IIB Bone Cancer AJCC v8

Stage IIB includes: T2, N0, M0, G2 or G3. T2: Tumor measuring more than 8 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Tectal Glioma

A glioma that arises from the tectum mesenchephali.


Grade 5 Hyperuricemia, CTCAE

Death


Grade 1 Activated Partial Thromboplastin Time Prolonged, CTCAE

>ULN-1.5 x ULN


Growth Hormone Abnormal, CTCAE

A finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen.


Grade 5 Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Adipsic Diabetes Insipidus

Diabetes insipidus complicated by a deficient or absent thirst response to hyperosmolality, usually as a result of hypothalamic damage or dysfunction.


Recurrent Schwannoma

The reemergence of schwannoma after a period of remission.


Grade 3 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Infant Acute Biphenotypic Leukemia

An acute biphenotypic leukemia that occurs in infancy.


Drug toxicity

An adverse effect of a drug used therapeutically or diagnostically.


Grade 3 Jejunal Obstruction, CTCAE

Hospitalization indicated; invasive intervention indicated; limiting self care ADL


Grade 3 Tongue Intra-Operative Injury, CTCAE


Stage IV Gastric Neuroendocrine Tumor AJCC v8

Stage IV includes: (T1, N0, N1, M1); (T2, N0, N1, M1); (T3, N0, N1, M1); (T4, N0, N1, M1). T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Non-IgM Monoclonal Gammopathy of Undetermined Significance

Monoclonal gammopathy of undetermined significance defined by the presence in the serum of an IgG, IgA, or (rarely) IgD paraprotein at a concentration of less than 30g/L; clonal bone marrow plasma cells less than 10%; and absence of end-organ damage such as hypercalcemia, renal insufficiency, anemia, bone marrow lesions, and amyloidosis attributable to the plasma cell proliferative disorder. The risk of progression to plasma cell myeloma, light-chain amyloidosis, or a related disorder is 1% per year. (WHO 2017)


Grade 3 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Endometrial Mixed Cell Adenocarcinoma

Endometrial mixed cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


Meningeal Lymphoma

Involvement of the meninges by Hodgkin or non-Hodgkin lymphoma.


Radiation-induced xerostomia

Dryness of the oral mucosa secondary to radiation therapy.


Grade 4 Middle Ear Inflammation, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Arterial Injury, CTCAE

Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


Grade 1 Sciatic Nerve Intra-Operative Injury, CTCAE


Urinary System Paraganglioma

An extra-adrenal paraganglioma that arises from the urinary system.


Grade 2 Carbon Monoxide Diffusion Capacity, CTCAE


Grade 4 Laryngeal Edema, CTCAE

Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Refractory Lymphoproliferative Disorder

Lymphoproliferative disorder that is resistant to treatment.


Grade 2 Fracture, CTCAE

Symptomatic but non-displaced; immobilization indicated


Penile Non-Neoplastic Disorder

A non-neoplastic disorder that affects the penis. Representative examples include phimosis, balanitis, and hypospadias.


Grade 3 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


large cell neuroendocrine carcinoma of appendix

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the appendix.  It is characterized by the presence of malignant large cells.


Grade 4 Hemorrhage and Bleeding, CTCAE Associated with Surgery, CTCAE


Grade 1 Middle Ear Inflammation, CTCAE

Serous otitis


Stage IVB Uterine Corpus Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, lung, liver, or bone. It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa). (from AJCC 8th Ed.)


Neoplasm of broad ligament

A benign, borderline, or malignant neoplasm that affects the broad ligament.


Bronchial Stricture, CTCAE

A disorder characterized by a narrowing of the bronchial tube.


Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive


Stage I Cervical Cancer FIGO 2009

The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2009)


Refractory Gliosarcoma

A gliosarcoma that is resistant to treatment.


Grade 1 Spleen Intra-Operative Injury, CTCAE


Spinal vascular disorder

A disorder that is caused by pathologic changes in the spinal vasculature.


Kidney Neuroendocrine Tumor

A well-differentiated neuroendocrine neoplasm arising from the kidney. It is characterized by the presence of uniform cells with stippled chromatin and inconspicuous nucleoli. Mitotic activity is low and tumor necrosis is absent.


Palmar-Plantar Erythrodysesthesia Syndrome, CTCAE

A disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet. Also known as Hand-Foot Syndrome.


Esophageal Schwannoma

A slowly growing, benign, usually encapsulated neoplasm arising from the esophagus.  Morphologically, it is composed of neoplastic differentiated Schwann cells.


Stage III Gestational Trophoblastic Tumor AJCC v7

Stage III includes: (Any T, M1a, Risk factors: unknown); IIIA (Any T, M1a, Risk factors: low risk); IIIB (Any T, M1a, Risk factors: high risk).  M1a: Lung metastasis.  (AJCC 7th ed.)


Grade 3 Night Blindness, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Posthemorrhagic hydrocephalus

An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a later sequela of an intraventricular or subarachnoid hemorrhage.


Grade 3 Laryngopharyngeal Dysesthesia, CTCAE

Severe symptoms; dyspnea and swallowing difficulty; limiting self care ADL


Grade 3 Lumbar Spine Range of Motion, CTCAE


Grade 3 Cranial Nerve II Intra-Operative Injury, CTCAE


Mixed Phenotype Acute Leukemia, B/T, Not Otherwise Specified

A very rare mixed phenotype acute leukemia, not otherwise specified in which the blasts show clear-cut evidence of both B-cell and T-cell lineage. (WHO 2017)


Grade 3 Biliary Tree NOS Intra-Operative Injury, CTCAE


Southern tick-associated rash illness

A putative Borrelia infection causing acute manifestations similar to Lyme disease, particularly erythema migrans, following the bite of the lone star tick, Amblyomma americanum.


Grade 4 Jejunal Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Refractory Osteosarcoma

Osteosarcoma that does not respond to treatment.


Cervical Mucoepidermoid Carcinoma

A rare carcinoma that arises from the cervix. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Grade 4 Cervix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Salivary Gland Fistula, CTCAE

Invasive intervention indicated


Grade 1 Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Gastric Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a gastric neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to gastric "carcinoid" tumors (NET G1 and G2, and rare well-differentiated G3). Gastric high-grade neuroendocrine carcinoma and gastric mixed adenoneuroendocrine carcinoma are not included in this staging system. (from AJCC 8th Ed.)


Grade 4 Hepatic Vein Intra-Operative Injury, CTCAE


Grade 1 Neuralgia, CTCAE

Mild pain


Grade 3 Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Penis Intra-Operative Injury, CTCAE


Refractory AL Amyloidosis

AL amyloidosis that does not respond to treatment.


Grade 4 Bone Growth Limb Length Discrepancy, CTCAE


Grade 2 Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pure Cutaneous Mastocytosis

Mastocytosis that manifests with pure cutaneous involvement.


Gastrointestinal Tract Acute Graft Versus Host Disease

Acute graft versus host disease occurring in the gastrointestinal tract.


Grade 3 Urticaria, CTCAE

Urticarial lesions covering >30% BSA; IV intervention indicated


Grade 1 Esophageal Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 5 Hemorrhage and Bleeding, CTCAE Associated with Surgery, CTCAE


Grade 3 Aphonia, CTCAE

Voicelessness; unable to speak


Stage III Ampulla of Vater Cancer AJCC v8

Stage III includes: IIIA: (T1a, N1, M0); (T1b, N1, M0); (T2, N1, M0); (T3a, N1, M0); (T3b, N1, M0); IIIB: (T4, Any N, M0); (Any T, N2, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. T4: Tumor involving the celiac axis, superior mesenteric artery, and/or common hepatic artery, irrespective of size. N1: Metastasis to one to three regional lymph nodes. N2: Metastasis to four or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Hodgkin's disease lymphocyte predominance type stage III

Stage III adult Hodgkin disease means the involvement of lymph node regions on both sides of the diaphragm (III), which may also be accompanied by localized involvement of an associated extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or by involvement of both (IIIE + S). Stage III disease may be subdivided by anatomic distribution of abdominal involvement or by extent of splenic involvement. Stage III(1) indicates involvement that is limited to the upper abdomen above the renal vein. Stage III(2) indicates involvement of pelvic and/or para-aortic nodes. Five or more visible splenic nodules on a cut section constitutes extensive splenic involvement. Zero to four nodules is classified as minimal splenic disease. (from PDQ)


Zoonoses

Infection by an etiologic agent that can be passed between animals and humans.


Renal Pelvis and Ureter Carcinoma

Carcinoma that affects the renal pelvis and ureter.


Grade 3 Kidney Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Bacterial pericarditis

Pericarditis that is caused by an infection with a bacterial agent.


Resectable Malignant Neoplasm

Malignant neoplasm that is amenable to surgical resection.


Breast Nevus

A benign melanocytic nevus that arises from the breast skin.


Aphonia, CTCAE

A disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic).


Adenocarcinoma in adenomatous polyp

A non-invasive or invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp.


Congenital facial nerve palsy

Partial or complete paralysis of the facial muscles of one side of an individual's face that is present at birth. It is caused by damage to the seventh cranial nerve.


Hypothyroxinemia

Decreased concentration of thyroxine.


Grade 1 Lactation Disorder, CTCAE

Mild changes in lactation, not significantly affecting production or expression of breast milk


Vulvar Small Cell Neuroendocrine Carcinoma

A rare small cell neuroendocrine carcinoma that arises from the vulva.


Peritoneal Infection

An infectious process affecting the peritoneum.


Stage IVA Vaginal Cancer AJCC v6 and v7

Stage IVA includes: T4, Any N, M0. T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4).  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Viremia, CTCAE

A disorder characterized by the presence of a virus in the blood stream.


Gastrointestinal Fistula, CTCAE 5.0

A disorder characterized by an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site.


Gastric Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures).


Grade 2 Neuralgia and Peripheral Nerve Pain, CTCAE


Advanced Non-Cutaneous Melanoma

Non-cutaneous melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Work shift change (disorder)

A subtype of circadian rhythm sleep disorder in which the individual exhibits a normal endogenous pattern of sleep and wakefulness, but this pattern comes into conflict with the desired pattern of sleep and wakefulness required by shift work.


Corneal foreign body (disorder)

External material in or on the cornea.


Grade 1 Genitourinary Stoma Stricture or Stenosis, CTCAE


Stage IIB Cervical Cancer FIGO 2018

Cervical carcinoma with parametrial involvement but not up to the pelvic wall. (FIGO 2018)


Grade 2 Intraoperative Ocular Injury, CTCAE

Partial resection of injured organ/structure indicated


Parapsoriasis en Plaques

A variant of parapsoriasis in which the plaques are large.


Grade 4 Anxiety, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Bronchial Obstruction, CTCAE

Symptomatic (e.g., mild wheezing); endoscopic evaluation indicated; radiographic evidence of atelectasis/lobar collapse; medical management indicated (e.g., steroids, bronchodilators)


Grade 4 Hematosalpinx, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Abdomen Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Unresectable Cutaneous Melanoma

A skin melanoma that is not amenable to surgical resection.


Grade 5 Nodal or Junctional Rhythm, CTCAE


Grade 1 Major Visceral Vein Intra-Operative Injury, CTCAE


Grade 4 Wound Dehiscence, CTCAE

Life-threatening consequences; symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated


Grade 4 Intraoperative Respiratory Injury, CTCAE


Grade 2 Esophageal Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Cutaneous Perineurioma

A rare perineurioma arising from the skin.


Grade 2 Iron Overload, CTCAE

Moderate symptoms; intervention not indicated


Late Prosthetic Valve Endocarditis

Prosthetic valve endocarditis that occurs several months to years following valve replacement.


Grade 4 Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Jejunal Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Lung Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Radiation damage to artery

A damage to arteries caused by radiation therapy.


Grade 3 Epistaxis, CTCAE

Transfusion; invasive intervention indicated (e.g., hemostasis of bleeding site)


Postoperative Spindle Cell Nodule of the Cervix

A rare, benign, non-neoplastic reactive lesion that develops in the cervix at the site of a prior operative procedure. It is composed of spindle cells, small blood vessels, and chronic inflammation.


Grade 1 Rectum Intra-Operative Injury, CTCAE


Grade 3 Peritoneal Necrosis, CTCAE

Tube feeding or TPN indicated; invasive intervention indicated


Metastatic Malignant Neoplasm in the Digestive System

A malignant neoplasm that has spread to the digestive system from another anatomic site.


Grade 2 Cataract, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); glare symptoms affecting instrumental ADL


Stage III Cutaneous Melanoma AJCC v7

Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 1 Bone Marrow Hypocellular, CTCAE

Mildly hypocellular or <=25% reduction from normal cellularity for age


Inflamed Juvenile Conjunctival Nevus

A compound nevus that arises from the conjunctiva in children and adolescents. It is characterized by the presence of chronic inflammatory features.


Unresectable Myxoid Liposarcoma

A myxoid liposarcoma that is not amenable to surgical resection.


Cheilitis, CTCAE

A disorder characterized by inflammation of the lip.


Grade 4 Hyperthyroidism, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Edema of the Trunk and Genital Area, CTCAE


Grade 3 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Fallopian Tube Hemorrhage, CTCAE


Grade 4 Neonatal Culture Negative Sepsis, AE

A culture negative neonatal sepsis adverse event in a newborn characterized by life-threatening consequences (e.g. shock, disseminated intravascular coagulation (DIC)); urgent major care change required.


Grade 5 Pneumonitis and Pulmonary Infiltrates, CTCAE


Upper Aerodigestive Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Grade 2 Gamma-Glutamyl Transpeptidase, CTCAE


Stage III Adult Diffuse Mixed Cell Lymphoma

Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Grade 4 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Appendix Carcinoma by AJCC v8 Stage

A term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas of the appendix, including high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and goblet cell carcinoids. Well-differentiated neuroendocrine tumors (carcinoids) are staged according to the classification for neuroendocrine tumors of the appendix. (from AJCC 8th Ed.)


Grade 3 Capillary Leak Syndrome, CTCAE

Severe symptoms; intervention indicated


Stage IA Vulvar Carcinoma AJCC v6

Stage IA includes: Tia, N0, M0.  T1a: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion no greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Assault by firearms

A physical attack with a gun.


Adenocarcinoma of the prostate stage II

Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Long-Term Effects Secondary to Cancer Therapy

Side effects of cancer treatment occurring a long time after the treatment was completed.


Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

A disorder characterized by headaches, mental status changes, visual disturbances, and/or seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition. Also known as posterior reversible encephalopathy syndrome (PRES).


Advanced Malignant Digestive System Neoplasm

A malignant digestive system neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Intraoperative Breast Injury, CTCAE

Partial resection of injured organ/structure indicated


Grade 1 Pneumothorax, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Subjective Fever

A symptom report of fever without an objective temperature measurement.


FIGO Stage III Gestational Trophoblastic Tumor

Lesion affects the lungs, with or without known genital structures invasion.


Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive

A chronic myelogenous leukemia occurring during childhood.


Grade 1 Myasthenia Gravis, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Mucosal nodular melanoma

Nodular melanoma that arises from a mucosal site.


Stage IIB Cervical Cancer FIGO 2009

Cervical carcinoma with parametrial invasion. (FIGO 2009)


Stage IVB Gestational Trophoblastic Tumor AJCC v7

Stage IVB includes: Any T, M1b, Risk factors: high risk.  M1b: All other distant metastasis.  (AJCC 7th ed.)


Chest Pain Along Anterior Axillary Line

The location of the chest pain is along an imaginary vertical line that descends along the lateral aspect of the chest wall originating from the armpit.


Astler-Coller B3 Colon Carcinoma

Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


FIGO Stage IIA Gestational Trophoblastic Tumor


Grade 1 Mucositis Oral, CTCAE

Asymptomatic or mild symptoms; intervention not indicated


Rectal Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the rectal region.


Grade 2 Rhinitis Infective, CTCAE

Localized; local intervention indicated


Liquid Tumor

A malignant tumor that originates from myeloid or lymphoid cells i.e., leukemias and lymphomas.


Benign fibrohistiocytic neoplasm

A benign mesenchymal neoplasm composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes, in a storiform pattern.


Bone Malignant Peripheral Nerve Sheath Tumor

An exceedingly rare malignant peripheral nerve sheath tumor that arises from the bone.


Lung Adenocarcinoma with Mixed Bronchioloalveolar and Invasive Components

A lung adenocarcinoma consisting of a bronchioloalveolar component and an invasive adenocarcinomatous component.


Grade 4 Pneumothorax, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Rectum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Multi-Organ Failure, CTCAE

A disorder characterized by progressive deterioration of the lungs, liver, kidney and clotting mechanisms.


Stage II Bone Cancer AJCC v7

Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 5 Somnolence and Depressed Level of Consciousness, CTCAE


Sarcoma of pelvis

Sarcoma involving the organs and structures of the pelvis.


Refractory Anaplastic Astrocytoma

An anaplastic astrocytoma that is resistant to treatment.


Old Burn Scar-Related Skin Squamous Cell Carcinoma

A squamous cell carcinoma of the skin that arises from burn scars. It usually manifests between 20 and 40 years after the original burn.


Grade 1 Weight Loss, CTCAE

5 to <10% from baseline; intervention not indicated


Grade 5 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Cartilage Intra-Operative Injury, CTCAE


Grade 3 Colonic Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 2 Penile Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Upper Aerodigestive Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Cervical Invasive Stratified Mucinous Adenocarcinoma

A rare, distinct form of invasive cervical mucinous adenocarcinoma associated with human papillomavirus infection. It is characterized by the presence of stratiﬁed, immature epithelial cells containing varying quantities of intracytoplasmic mucin.


Ileal Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the ileum.


Grade 1 Hemolysis, CTCAE

Laboratory evidence of hemolysis only (e.g., direct antiglobulin test; DAT; Coombs'; schistocytes; decreased haptoglobin)


Stage IVB Appendix Carcinoma AJCC v7

Stage IVB includes: (Any T, N0, M1a, G2, G3); (Any T, N1, M1a, Any G); (Any T, N2, M1a, Any G).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N2: Metastasis in four or more regional lymph nodes.  M1a: Intraperitoneal metastasis beyond the right lower quadrant, including pseudomyxoma peritonei.  G2: Moderately differentiated tumor. G3: Poorly differentiated tumor.  (AJCC 7th ed.)


Neoplasm of uncertain behavior

A neoplasm displaying morphologic, phenotypic, or genotypic characteristics that are clearly not benign but do not permit the establishment of a definitive diagnosis of malignancy.  Such neoplasms may or may not eventually have a more aggressive clinical course.  Representative examples include lymphoproliferations of uncertain malignant potential (e.g., lymphomatoid granulomatosis and lymphomatoid papulosis), borderline ovarian epithelial neoplasms (e.g., borderline ovarian endometrioid tumor and borderline ovarian mucinous tumor), borderline exocrine pancreatic neoplasm (e.g., pancreatic borderline intraductal papillary-mucinous neoplasm), and primary borderline peritoneal epithelial neoplasm.


Grade 2 Fatigue, CTCAE

Fatigue not relieved by rest; limiting instrumental ADL


Hernia, Diaphragmatic, Traumatic

The protrusion of abdominal cavity contents into the thoracic cavity via a hole in the diaphragm, which was acquired via a traumatic etiology.


Peritoneal and retroperitoneal haemorrhages

Bleeding originating in and behind the tissues that line the wall of the abdominal cavity, intestine, and mesentery.


Grade 1 Vomiting, CTCAE

Intervention not indicated


Grade 2 Menorrhagia, CTCAE

Moderate symptoms; medical intervention indicated (e.g., hormones)


Grade 2 Neonatal Culture Positive Sepsis, AE

An adverse event in a newborn characterized by a positive blood culture positive with mild or ambiguous signs; anti-infectives initiated.


Grade 5 Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Unresectable Urothelial Carcinoma

Urothelial carcinoma that is not amenable to surgical resection.


Adverse Event Associated with Dermatology and Skin


Grade 4 Neonatal Hypotension, AE

A hypotensive adverse event in a newborn characterized by life-threatening consequences (e.g. shock, organ failure).


Recurrent Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

The reemergence of undifferentiated high grade pleomorphic sarcoma of bone in adulthood after a period of remission.


Pyramidal Tract Syndrome, CTCAE

A disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination.


Metastatic Sarcoma in the Peritoneum

A sarcoma that has spread to the peritoneum from an adjacent or distal anatomic site.


Tumor Flare Reaction

A side effect of cancer treatment. It has been described in patients with chronic lymphocytic leukemia treated with lenalidomide, breast cancer patients during the initial phase of hormonal treatment, and in prostate cancer patients treated with luteinizing hormone-releasing hormone agonists. Symptoms include a sudden and painful increase in the tumor size, rash, low grade fever, bone pain, hypercalcemia, and an increase in the tumor markers levels.


Grade 5 Upper Extremity Artery Injury, CTCAE


Grade 3 Gait Disturbance, CTCAE

Limiting self care ADL


Grade 3 Cranial Nerve III Intra-Operative Injury, CTCAE


Refractory Pancreatobiliary Carcinoma

Pancreatobiliary carcinoma that is resistant to treatment.


Grade 2 Renal Calculi, CTCAE

Symptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated


Acquired phimosis

Phimosis that develops in an uncircumcised male with a previously loose foreskin.


Platinum-Resistant Fallopian Tube Carcinoma

Fallopian tube carcinoma that progresses between one and six months of completing the last platinum therapy.


Recurrent Langerhans Cell Histiocytosis

The reemergence of Langerhans cell histiocytosis after a period of remission.


Grade 3 Ileum Stricture or Stenosis, CTCAE


Undifferentiated schizophrenia

A subtype of schizophrenia in which the individual exhibits the characteristic symptoms of schizophrenia but the overall picture is not one of catatonic type, paranoid type, or disorganized type schizophrenia.


Stent thrombosis

The formation of a blood clot of a vessel or heart chamber after and due to the placement of a stent.


Grade 1 Generalized Edema, CTCAE

Noted on exam; 1+ pitting edema


Foregut Cyst

A cyst originating from the primitive foregut.  It may arise from the upper aerodigestive tract, tracheobronchial tree, liver, and pancreas.


Stage IIB Nasopharyngeal Keratinizing Squamous Cell Carcinoma


Hairy Polyp

A benign polypoid lesion that usually arises from the nasopharynx. It may also occur in the oropharynx, palate, tonsil, tongue, lip, and middle ear. It usually affects neonates and older infants and is composed of ectoderm and mesoderm.


Chronic Bacterial Prostatitis

A chronic infection of the prostate gland caused by bacteria.  It is manifested with recurring urinary tract infections.  The culture of the prostatic fluid, semen, or post-massage urine specimen reveals the presence of bacteria.


Abducens Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the abducens nerve (sixth cranial nerve).


Grade 4 Hypernatremia, CTCAE

>160 mmol/L; life-threatening consequences


Oculomotor Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the oculomotor nerve (third cranial nerve).


Stage I Cervical Cancer AJCC v9

Stage I includes: T1, N0, M0. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


MAC lymphadenitis

Lymph node infection by Mycobacterium avium or Mycobacterium intracellulare. It most often affects children and usually presents with cervical lymph node enlargement. It generally follows a benign clinical course.


Malignant fibrohistiocytic neoplasm

A fibrohistiocytic neoplasm that metastasizes to other anatomic sites.


Grade 5 Urinary Retention, CTCAE

Death


Oligometastatic Prostate Carcinoma

Prostate carcinoma that has metastasized to a limited number of sites.


Grade 2 Colonic Stenosis, CTCAE

Symptomatic; altered GI function


Grade 3 Ureter Intra-Operative Injury, CTCAE


Terrifying Pain

A sensation of discomfort or distress that is frightening or scary.


Grade 3 Prostate Stricture or Stenosis, CTCAE


Grade 5 Renal and Urinary Disorders - Other, Specify, CTCAE

Death


Grade 3 Esophageal Perforation, CTCAE

Invasive intervention indicated


Mixed Morphea

The presence of more than one variant of morphea in a single patient.


Stage III Vaginal Cancer AJCC v6 and v7

Stage III includes: (T1-3, N1, M0) and (T3, N0, M0). T1: Tumor confined to vagina.  T2: Tumor invades paravaginal tissues but not to pelvic wall.  T3: Tumor extends to pelvic wall.  N0: No regional lymph node metastasis.  N1: Pelvic or inguinal lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 5 Anal Fistula, CTCAE

Death


Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Airway Tumor Mass

A tumor mass that is located in the airways.


Grade 1 Scrotal Pain, CTCAE

Mild pain


Grade 2 Upper Aerodigestive Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


Psammocarcinoma

An extremely rare variant of serous carcinoma arising from the ovary or peritoneum. It is characterized by extensive formation of psammoma bodies, low-grade cytological features, and invasion of surrounding structures.


Grade 4 Atrial Fibrillation, CTCAE

Life-threatening consequences; embolus requiring urgent intervention


Refractory Adenoid Cystic Carcinoma

Adenoid cystic carcinoma that is resistant to treatment.


Recurrent Skin Carcinoma

A carcinoma of the skin that has recurred after a period of remission.


Locally Advanced Malignant Digestive System Neoplasm

A malignant digestive system neoplasm that has spread to nearby tissues or lymph nodes.


Stage III Esophageal Adenocarcinoma AJCC v7

Stage III includes: IIIA (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G); IIIB (T3, N2, M0, Any G); IIIC (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 1 Gallbladder Fistula, CTCAE

Asymptomatic


Grade 4 Parathyroid Intra-Operative Injury, CTCAE


High-Grade Biliary Intraepithelial Neoplasia

Biliary intraepithelial neoplasia characterized by the presence of high grade epithelial dysplasia.


Grade 4 Small Intestinal Mucositis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Delusions, CTCAE

Moderate delusional symptoms


Eyelid Function Disorder, CTCAE

A disorder characterized by impaired eyelid function.


Stage IVA Bone Sarcoma AJCC v7

Stage IVA includes: Any T, N0, M1a, Any G.  N0: No regional lymph node metastasis.  M1a: Distant metastasis to lung. (AJCC 7th ed.)


Grade 3 Rectal Mucositis, CTCAE

Severe symptoms; limiting self care ADL


Metastatic Neoplasm to the Gallbladder

A malignant neoplasm that has spread to the gallbladder from another anatomic site.  Representative examples include metastatic melanoma, and metastatic carcinomas from the breast and the stomach.


Appendix Low Grade Intraepithelial Neoplasia

A precancerous intraepithelial neoplastic lesion that affects the appendix.  It is characterized by the presence of mild dysplasia and mild architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


Grade 2 Stomal Ulcer, CTCAE

Symptomatic; medical intervention indicated


Suppurative Granuloma

A granuloma caused by infectious organisms and characterized by the presence of abscess formation.


Grade 1 Pelvis NOS Intra-Operative Injury, CTCAE


Neuroendocrine Carcinoma, Excluding Head and Neck

A high-grade carcinoma with neuroendocrine differentiation. This category includes small cell carcinomas, large cell neuroendocrine carcinomas, and Merkel cell carcinomas and excludes neuroendocrine carcinomas that arise from the head and neck. The head and neck neuroendocrine carcinomas include well-differentiated, moderately-differentiated, and poorly-differentiated (high-grade) neuroendocrine carcinomas.


Thrombosis of blood vessel

The formation of a blood clot in the lumen of a vessel; causes include coagulation disorders, and vascular endothelial injury.


Grade 3 Ileal Perforation, CTCAE

Invasive intervention indicated


Stoma Site Infection, CTCAE

A disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body).


CD4 Lymphocytes Decreased, CTCAE

A finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen.


Grade 3 Generalized Edema, CTCAE

Interferes with self care ADL; intravenous therapy indicated; skin breakdown


Trichoadenoma

A rare benign tumor of the hair follicle occurring usually in the face or buttocks.


Hepatitis B Reactivation, CTCAE

A disorder characterized by the reactivation of hepatitis B virus.


Pathologic Stage III Cutaneous Melanoma AJCC v8

Stage III includes: IIIA: (T1a/b-T2a, N1a or N2a, M0); IIIB: (T0, N1b, N1c, M0); (T1a/b-T2a, N1b/c or N2b, M0); (T2b/T3a, N1a-N2b, M0); IIIC: (T0, N2b, N2c, N3b or N3c); (T1a-T3a, N2c or N3a/b/c, M0); (T3b/T4a, Any N greater than or equal to N1, M0); (T4b, N1a-N2c, M0); IIID: (T4b, N3a/b/c, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N2c: One clinically occult nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 1 Testicular Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 3 Pancreas Intra-Operative Injury, CTCAE


Supraventricular Tachycardia, CTCAE

A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles.


Pancreatic Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the pancreas.


Stage I Anal Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor 2 cm or smaller. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Upper Airway Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Grade 3 Infusion Related Reaction, CTCAE

Prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae


A hepatocellular adenoma caused by inactivating mutations of the HNF1A gene.  It is characterized by the presence of lobulated contours, steatosis, and absence of inflammation or nuclear atypia.


Lower Extremity Soft Tissue Necrosis, CTCAE


Pharyngeal Hemorrhage, CTCAE

A disorder characterized by bleeding from the pharynx.


Chest Pain in Mid Sternum

The location of the chest pain is in the middle of the sternum.


Grade 4 Pleura Intra-Operative Injury, CTCAE


Grade 5 Gallbladder Obstruction, CTCAE

Death


Simple Endometrial Hyperplasia with Atypia

A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is present.


Grade 1 Paronychia, CTCAE

Nail fold edema or erythema; disruption of the cuticle


Cervical carcinoma stage II AJCC v7

Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0); IIB (T2b, N0, M0); T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 4 Rectal Mucositis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 1 Neck Edema, CTCAE

Asymptomatic localized neck edema


Childhood Malignant Central Nervous System Neoplasm

Malignant neoplasms which occur in the brain, spinal cord, or meninges of children.  Brainstem gliomas, medulloblastomas, ependymomas, and certain pineal tumors are relatively common primary malignant tumors of the CNS in children.


Grade 3 Glossopharyngeal Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Juvenile systemic scleroderma

Systemic sclerosis that is diagnosed in children. Juvenile systemic sclerosis is more likely to be of the overlap variant and presents with musculoskeletal involvement.


Grade 5 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Spontaneous Perforation

A hole through the wall of an organ that occurs without external influence.


Grade 4 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cancer Fatigue

A debilitating tiredness or total lack of energy, often reported as the most common symptom in individuals with cancer.  Cancer fatigue can result from chemotherapy, radiation therapy, surgery, and other treatments; chemotherapy-induced anemia is a very frequent cause. -- 2004


Pancreatic Hemorrhage, CTCAE

A disorder characterized by bleeding from the pancreas.


Grade 4 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


Uterine Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures).


Grade 1 Sinus Pain, CTCAE

Mild pain


Precursor T-lymphoblastic lymphoma/leukemia stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, or nodular involvement of the lungs(s).


Clinical Stage III Retinoblastoma AJCC v8

Stage III includes: (cT4b, cN0, cM0, Any H); (Any cT, cN1, cM0, Any H). cT4b: Extraocular tumor clinically evident with proptosis and/or an orbital mass. cN0: No regional lymph node involvement. cN1: Evidence of preauricular, submandibular, and cervical lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Grade 3 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Grade 1 Phlebitis Infective, CTCAE

Localized, local intervention indicated


Stage II Testicular Cancer AJCC v8

Stage II includes: Any pT/TX, N1-3, M0, SX. TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Grade 4 Urostomy Site Bleeding, CTCAE

Life-threatening consequences; urgent intervention indicated


Congenital ankyloblepharon

A congenital abnormality in which the margins of the upper and lower eyelids are fused together by bands of tissue.


Grade 3 Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Spiradenocylindroma

A benign adnexal neoplasm with histological features of both spiradenoma and cylindroma in a single nodular lesion.


Grade 4 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Facial Pain, CTCAE

Mild pain


Midgut Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the jejunum, ileum, proximal colon, or appendix. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Grade 4 Ventricular Arrhythmia NOS, CTCAE


Thrombosis or Thrombus or Embolism, CTCAE


Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Cutaneous Fistula

An abnormal communication between the skin and another organ or cavity.


Grade 4 Duodenum Stricture or Stenosis, CTCAE


Grade 4 Jejunum Intra-Operative Injury, CTCAE


Metastatic Genitourinary System Carcinoma

A carcinoma that arises from the genitourinary system and has metastasized to other anatomic sites.


Unresectable Anal Squamous Cell Carcinoma

Anal squamous cell carcinoma that is not amenable to surgical resection.


Malignant cylindroma

A carcinoma that arises in a cylindroma.


Grade 2 Hepatitis Viral, CTCAE

Moderate symptoms; medical intervention indicated


Grade 5 Obstruction Gastric, CTCAE

Death


Grade 1 Supraventricular Tachycardia, CTCAE

Asymptomatic, intervention not indicated


Unresectable Pancreatic Neuroendocrine Neoplasm

A pancreatic neuroendocrine neoplasm that is not amenable to surgical resection.


Grade 2 Tracheal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Radiating Chest Pain Along Left Middle Sternal Border

The location of the radiating chest pain is along the left middle sternal border.


Non-Neoplastic Hair Disorder

A non-neoplastic disorder that affects the hair. Representative examples may include alopecia, male pattern baldness, hirsutism, and hair shaft disorders.


Increased NPN

A laboratory test result indicating abnormally high concentration of non-protein nitrogen in the blood.


Grade 5 Intraoperative Musculoskeletal Injury, CTCAE

Death


High Grade Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


Grade 1 Small Intestinal Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Major Visceral Vein Intra-Operative Injury, CTCAE


Grade 4 Vein NOS Intra-Operative Injury, CTCAE


Lugano Classification Stage IE Adult Hodgkin Lymphoma AJCC v8

Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Grade 2 Nose Intra-Operative Injury, CTCAE


Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Iron Overload, CTCAE

Severe symptoms; intervention indicated


Grade 2 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent

Acute myeloid leukemias and myelodysplastic syndromes arising as a result of the mutagenic effect of alkylating agents that are used for the treatment of malignant tumors. Patients usually develop a myelodysplastic syndrome which may evolve to a higher grade myelodysplastic syndrome or acute myeloid leukemia. A minority of patients present with an acute myeloid leukemia. Clonal cytogenetic abnormalities are frequently present and usually are unbalanced translocations or deletions of chromosomes 5 and 7. Patients with acute myeloid leukemia usually do not respond to treatment and have an unfavorable clinical outcome.


Seminal Vesicle Squamous Cell Carcinoma

An extremely rare squamous cell carcinoma that arises from the seminal vesicle. Glandular formation and mucin secretion are absent.


Grade 4 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Gastrointestinal Leak NOS, CTCAE


Respiratory, Thoracic and Mediastinal Disorders, CTCAE


Grade 2 Irregular Menstruation, CTCAE

Intermittent/irregular menses for more than 3 consecutive menstrual cycles


Intermediate Grade Lung Neuroendocrine Neoplasm

An intermediate grade malignant neoplasm with neuroendocrine differentiation that arises from the lung.  This category includes atypical carcinoid tumor.


Disorder of AMH Receptor

A defect in the Anti-Muellerian hormone receptor.


Childhood L2 Acute Lymphoblastic Leukemia

L2 acute lymphoblastic leukemia that occurs during childhood.


Grade 3 Cranial Nerve X Intra-Operative Injury, CTCAE


Grade 1 Vulval Infection, CTCAE

Localized, local intervention indicated


Grade 3 Cranial Nerve VII Neuropathy, CTCAE


Grade 2 Breast Function and Lactation, CTCAE


Mitochondrial Hydroxyacyl-Coenzyme A Dehydrogenase Hyperinsulinism

Hyperinsulinism due to inactivating mutation(s) in the gene HADH, encoding mitochondrial (short-chain) hydroxyacyl-coenzyme A dehydrogenase, resulting in loss of inhibition of glutamate dehydrogenase (GDH). This condition is also characterized by protein-induced hypoglycemia, but in contrast to GLUD1-associated hyperinsulinism, hyperammonemia is absent.


Grade 5 Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Human Papillomavirus-Related Cervical Squamous Cell Carcinoma

A cervical squamous cell carcinoma associated with human papillomavirus infection.


Circumferential Endothelial Hyperplasia

Intraluminal hyperplasia of endothelial cells, encircling the entire lumen.


Syncope, CTCAE 5.0

A disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain.


Grade 5 Central Nervous System Necrosis, CTCAE

Death


Grade 3 Wound Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 4 Neonatal Edema, AE

An edema adverse event in a newborn characterized by life threatening consequences (e.g. respiratory failure, shock); requiring urgent major care changes (e.g. intubation, dialysis).


Grade 4 Superior Vena Cava Vein Injury, CTCAE


Grade 2 Persistent Pulmonary Hypertension of the Newborn, AE

An adverse event in a newborn characterized by increased estimated right ventricular pressures; with moderate clinical symptoms; oxygenation index less than 25; minor care changes required.


Refractory Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma that is resistant to treatment.


Grade 4 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Arterial Thromboembolism, CTCAE

Life-threatening consequences; hemodynamic or neurologic instability; organ damage; loss of extremity(ies)


Grade 1 Neuroendocrine Gonadotropin Secretion Abnormality, CTCAE


Grade 4 Spinal Cord Compression, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Grade 5 Fallopian Tube Anastomotic Leak, CTCAE

Death


Grade 3 Pelvic Pain, CTCAE

Severe pain; limiting self care ADL


Stage I Uterine Corpus Cancer AJCC v8

Stage I includes: T1, N0, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Second degree uterine prolapse

The uterus has descended to the level of the hymen.


Grade 2 Hyperkalemia, CTCAE

>5.5-6.0 mmol/L; intervention initiated


Grade 3 Cranial Nerve VI Neuropathy, CTCAE


Grade 4 Other Metabolic and Laboratory, CTCAE


Grade 4 Hyperuricemia, CTCAE

Life-threatening consequences


High grade glandular intraepithelial neoplasia

A high grade intraepithelial neoplasia in which there is marked architectural distortion and crowding of the glands, associated with severe cellular atypia. The neoplastic cells display pleomorphic and hyperchromatic nuclei.


Grade 1 Heart Failure, CTCAE

Asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities


Pancreatic Enzymes Decreased, CTCAE

A finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen.


Malignant tumor of epidermal appendage

A malignant neoplasm that arises from the skin appendages.


Stage III Adult Diffuse Large Cell Lymphoma

Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Lipomatosis of Nerve

A tumor composed of mature adipocytes and fibrous tissue infiltrating the epineurium and peripheral nerves.  It is often seen at birth or during childhood and may be associated with macrodactyly.


Grade 2 Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Lower Extremity Intra-Operative Injury, CTCAE


Human Papillomavirus-Related Anal Squamous Cell Carcinoma

An anal squamous cell carcinoma related to infection with sexually transmittable human papillomavirus.


Grade 3 Retroperitoneal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Helicobacter Pylori-Related Carcinoma

A carcinoma that is caused by Helicobacter pylori.


Unresectable Neuroendocrine Tumor

A neuroendocrine tumor that is not amenable to surgical resection.


Local infection skin/subcut tissue NOS

An infection involving the surface of the skin and subcutaneous tissues in a defined area of the body.


Stage IIIB Uterine Corpus Cancer AJCC v7

Stage IIIB includes: T3b, N0, M0.  T3b: Tumor involves vagina (direct extension or metastasis) or parametrial tissue. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Grade 2 Pelvic Floor Muscle Weakness, CTCAE

Symptomatic, not interfering with bladder, bowel, or vaginal function; limiting instrumental ADL


Metastatic Non-Functioning Neuroendocrine Tumor

A non-functioning, well-differentiated neuroendocrine neoplasm that has spread from the original site of growth to another anatomic site.


Grade 2 Neonatal Respiratory Distress Syndrome, AE

An adverse event in a newborn characterized by clinical evidence of increased respiratory distress without significant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); corrected by minor adjustments in current ventilatory support, supplemental oxygen or non-invasive support.


Grade 1 Small Intestine Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


High Grade Prostatic Intraepithelial Neoplasia, Foamy Variant

High grade prostatic intraepithelial neoplasia characterized by the presence of large glands with papillary infoldings that contain cells with xanthomatous cytoplasm.


Urinary Incontinence, CTCAE 5.0

A disorder characterized by inability to control the flow of urine from the bladder.


Tooth Abrasion

Wearing away of tooth enamel by an outside mechanical force.


Lacrimal Drainage System Carcinoma

A carcinoma that arises from the lacrimal sac, canaliculi, or nasolacrimal duct.


Chronic Intestinal Cryptosporidiosis

A chronic infection caused by Cryptosporidium parvum or hominis that manifests as enteritis. It usually occurs in immunocompromised patients including persons with AIDS, transplant recipients, patients receiving cytotoxic chemotherapy, and patients with hematologic malignancies.


Cortical Cataract Grade 2

A stage of cortical cataract characterized by 10-50% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Grade 3 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Automobile Accident

An accident occurring while aboard, or involving, an automobile.


Otitis External Ear Non Infectious, CTCAE


Grade 2 Biliary Tree NOS Intra-Operative Injury, CTCAE


Grade 3 Other Hemorrhage and Bleeding, CTCAE


Grade 3 Gastritis, CTCAE

Severely altered eating or gastric function; TPN or hospitalization indicated


Grade 1 Pancreatic Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 4 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Tumor Hemorrhage, CTCAE

Death


Grade 5 Upper Respiratory Infection, CTCAE

Death


Vaccine associated paralytic poliomyelitis

A rare, paralytic poliomyelitis associated with the orally administered live attenuated strain of the poliovirus, OPV.


Esophageal Adenocarcinoma by AJCC v8 Postneoadjuvant Therapy Stage

A term that refers to the postneoadjuvant therapy staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 2 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Urostomy Obstruction, CTCAE

A disorder characterized by blockage of the urostomy.


Stage III Cervical Cancer FIGO 2018

Cervical carcinoma that involves the lower third of the vagina and/or extends to the pelvic wall and/or causes hydronephrosis or nonfunctioning kidney and/or involves pelvic and/or para-aortic lymph nodes. (FIGO 2018)


Grade 4 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Malignant Digestive System Neoplasm

A malignant neoplasm that arises in the digestive system and has spread from its original site of growth to other anatomic sites.


Stage IV Pancreatic Cancer AJCC v6 and v7

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


Grade 2 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Fallopian Tube Mucinous Adenocarcinoma

The reemergence of fallopian tube mucinous adenocarcinoma after a period of remission.


Bladder Granular Cell Tumor

A rare granular cell tumor arising from the bladder. Most tumors are benign.


Epididymal Cystadenoma

A benign cystadenoma in the epididymal ducts.


Anal Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the anal canal.


Venous lake

A condition that is characterized by venous dilation, which presents as soft, compressible lesions.


Grade 1 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Central Nervous System Neoplasms, Primary

A benign or malignant neoplasm that arises from the brain or the spinal cord.


Serum Calcitonin Level Increased

A laboratory test result indicating an increased concentration of calcitonin in the blood serum.


Grade 4 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Moderate Adverse Event

An experience that is alleviated with simple therapeutic treatments. The event impacts usual daily activities. Includes laboratory test alterations indicating injury, but without long-term risk.


Cystic urethritis

A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by urothelial cells.


Peritoneal Infection, CTCAE

A disorder characterized by an infectious process involving the peritoneum.


Grade 1 Pulmonary Fibrosis Radiographic Changes, CTCAE


Substance Withdrawal Delirium

A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance withdrawal.


Grade 3 Infective Myositis, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Venous Angioleiomyoma

A morphologic variant of angioleiomyoma characterized by the presence of thick-walled veins.


Grade 4 Hypoxic Ischemic Encephalopathy, AE

An adverse event in a newborn characterized by severe clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event with life-threatening consequences (e.g. respiratory depression, refractory seizures).


Malignant neoplasm musculoskeletal

A primary or metastatic malignant neoplasm that affects muscles and bones.


Sacral Plexus Intra-Operative Injury, CTCAE


Gingival odontogenic cyst

An odontogenic cyst found in the alveolar mucosa. (WHO 2017)


Grade 1 Kidney Intra-Operative Injury, CTCAE


Grade 4 Pancreatic Necrosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Direct Contact Transmission Infection

Infection produced by direct contact with another person.


Congenital hydroureter

Dilatation of the ureter caused by obstruction of urine flow that is present at birth.


Vulval Infection

An infectious process affecting the vulva. Causative agents include human papillomavirus, herpes virus, Trichomonas, and Candida. Symptoms include itching and pain in the genital area and discharge.


Adult Lymphocyte-Rich Classical Hodgkin Lymphoma

Lymphocyte-rich classic Hodgkin lymphoma that occurs in adults.


Grade 4 Bladder Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Mediastinum Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Forced Expiratory Volume Decreased, CTCAE


Conjunctival Compound Nevus

A compound nevus that arises from the conjunctiva. It usually occurs in the bulbar conjunctiva, caruncle, and plica semilunaris. It is characterized by the presence of nevus cells within the epithelium and in the substantia propria. Type A nevus cells are present in the junctional nests and superficial substantia propria, and type B nevus cells are present in the deeper layers of the subepithelial compartment.


Grade 3 Hyperlipidemia, CTCAE

Hospitalization; pancreatitis


Grade 5 Ascites, CTCAE

Death


Grade 2 Nasopharynx Intra-Operative Injury, CTCAE


Troublesome Pain

A sensation of discomfort or distress that worries an individual or interrupts their ability to complete desired activities.


Childhood Acute Myelomonocytic Leukemia

An acute myelomonocytic leukemia occurring in children.


Telangiectasia, CTCAE 5.0

A disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes.


Pneumococcal arthritis and polyarthritis


Third degree perineal laceration

Injury to perineum involving anal sphincter complex. (adapted from reVITALize)


Aggressive osteoblastoma

An osteoblastoma characterized by the presence of prominent epithelioid osteoblasts and recurrences.


Upper Airway NOS Intra-Operative Injury, CTCAE


Grade 2 Device Related Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal)


Advanced Digestive System Neuroendocrine Neoplasm

A digestive system neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Jejunal Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the intestinal contents in the jejunum.


Refractory Malignant Brain Neoplasm

A malignant brain neoplasm that is resistant to treatment.


Grade 1 Seroma, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IB Bone Sarcoma AJCC v7

Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Laryngopharyngeal Dysesthesia, CTCAE

A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx.


Infiltrating Ureter Urothelial Carcinoma with Glandular Differentiation

An infiltrating urothelial carcinoma of the ureter that exhibits glandular differentiation.


Grade 1 Spermatic Cord Perforation, CTCAE


Grade 3 Perforation Bile Duct, CTCAE

Invasive intervention indicated


Infant Acute Lymphoblastic Leukemia with MLL Rearrangement

An acute lymphoblastic leukemia with rearrangement of the MLL (KMT2A) gene that occurs in infancy.


Multicystic mesothelioma, benign

An intermediate grade neoplasm arising from mesothelial cells. It occurs in the peritoneum, extraperitoneal space, omentum, or pelvic or abdominal viscera. It is characterized by the presence of multiple cysts lined by flattened or cuboidal mesothelial cells. There is no evidence of significant cytologic atypia or increased mitotic activity. It usually occurs in young to middle-aged women. Patients present with abdominal or pelvic mass and pain. Approximately half of the cases recur. The recurrences may appear several years after the initial diagnosis. Rare cases of transformation to malignant mesothelioma have also been described.


Myeloid Neoplasms with Germline ETV6 Mutation

Autosomal dominant familial thrombocytopenia associated with germline ETV6 mutation and hematologic malignancies. The hematologic malignancies reported are diverse, including myelodysplastic syndrome, acute myeloid leukemia, chronic myelomonocytic leukemia, B lymphoblastic leukemia, and plasma cell myeloma. Non-hematological neoplasms, including colorectal adenocarcinoma, have been also reported in affected families. (WHO 2017)


supravesical fissure of urinary bladder

A urogenital anomaly characterized by infraumbilical exstrophy of a bladder open only in its upper portion and pubic diastasis.  It has been described in both males and females and may be associated with trisomy 18, omphalocele, and urethral duplication.


Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pulmonary Vein Intra-Operative Injury, CTCAE


Grade 1 Cranial Nerve XII Neuropathy, CTCAE


Vaginal Discharge, CTCAE

A disorder characterized by vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years.


Thrombosis or Embolism Vascular Access Related, CTCAE


Lymphangitis carcinomatosa

Extensive infiltration of the lymphatic vessels by cancer cells, resulting in widespread cancer dissemination.  The lymphatic vessels appear as palpable, cord-like structures, especially in skin areas overlying the carcinoma.


Grade 5 Small Intestine Ulcer, CTCAE

Death


Grade 3 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Postneoadjuvant Therapy Stage I Esophageal Adenocarcinoma AJCC v8

Stage I includes: T0-2, N0, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Lower Extremity Artery Intra-Operative Injury, CTCAE


Intratubular large cell hyalinizing Sertoli cell neoplasia

A clinically benign intratubular neoplastic proliferation of large Sertoli cells in the testis. It is associated with prominent basement membrane deposits. It occurs almost exclusively in patients with Peutz-Jeghers syndrome.


Grade 5 Urinary Tract Obstruction, CTCAE

Death


Grade 2 Hematuria, CTCAE

Symptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL


Voiding Disorders

A group of conditions comprising dysfunction of the storage and elimination of urine.


Grade 4 Mediastinum Intra-Operative Injury, CTCAE


Alcohol Intolerance, CTCAE

A disorder characterized by an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches.


Grade 1 Duodenal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Spongioneuroblastoma

A neuroectodermal tumor composed of neoplastic neural elements.


Grade 4 Restrictive Cardiomyopathy, CTCAE

Refractory heart failure or other poorly controlled cardiac symptoms


Grade 2 Eyelid Function Disorder, CTCAE

Symptomatic; nonoperative intervention indicated; limiting instrumental ADL


Cyst of hydatid of Morgagni

A cystic structure located between the ovary and fallopian tube.


Stage IV Gestational Trophoblastic Tumor AJCC v7

Stage IV includes: (Any T, M1b, Risk factors: unknown); IVA (Any T, M1b, Risk factors: low risk); IVB (Any T, M1b, Risk factors: high risk).  M1b: All other distant metastasis.  (AJCC 7th ed.)


Inferior Vena Cava Intra-Operative Injury, CTCAE


Pathologic Stage IA Esophageal Adenocarcinoma AJCC v8

Stage IA includes: (T1a, N0, M0, G1); (T1a, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. (AJCC 8th ed.)


Grade 2 Pancreatic Endocrine Glucose Intolerance, CTCAE


Grade 2 Urinary Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 1 Herpes Simplex Reactivation, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Post-biopsy Pain

A sensation of discomfort secondary to sampling of tissue or bodily fluid.


Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Differentiated vulvar intraepithelial neoplasia

HPV-negative vulvar squamous intraepithelial proliferation characterized by atypia of the basal and parabasal keratinocytes in an otherwise well-differentiated epithelium. Despite its subtle appearance, it has a high risk of malignant transformation. (WHO 2020)


Stage II Contiguous Adult Diffuse Large Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 2 Peritoneal Cavity Hemorrhage, CTCAE


Gallbladder Hyperplastic Polyp

A polypoid tumor that arises from the gallbladder.  It is characterized by the presence of elongated, serrated crypts lined by proliferative epithelium.


Grade 1 Intraoperative Neurological Injury, CTCAE

Primary repair of injured organ/structure indicated


Hernia of unspecified site without mention of obstruction or gangrene

The protrusion of an organ, or the fascia of an organ, through the wall of the cavity that normally contains it, without mention of obstruction or necrosis of the herniated contents.


Stage IB2 Cervical Cancer FIGO 2018

Invasive cervical carcinoma equal or more than 2 cm and less than 4 cm in greatest dimension. (FIGO 2018)


Combined Nevus

A nevus that contains two or more melanocytic nevus components in the same lesion. The cellular components can be any combination of any nevus variants, but most frequently, a common nevus component is combined with a blue nevus, deep penetrating nevus, or Spitz nevus component. (WHO 2018)


Grade 2 Larynx Obstruction and Stenosis, CTCAE


Luminal A Prostate Carcinoma

Prostate carcinoma associated with increased androgen receptor expression and signaling (androgen activity pathway), increased luminal markers, and a lower proliferation score than the luminal B and basal-like prostate carcinomas.


Pancreatic Medullary Carcinoma

A pancreatic ductal adenocarcinoma characterized by poor differentiation and a prominent syncytial growth pattern.  The prognosis is more favorable compared to conventional pancreatic ductal adenocarcinoma.


Sudden Death Not Associated with More Specific CTCAE Term, CTCAE


Refractory Urethral Urothelial Carcinoma

Urethral urothelial carcinoma that is resistant to treatment.


Acute perforated appendicitis

Acute appendicitis with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.


Childhood Hematopoietic and Lymphoid Cell Neoplasm


Weight Gain, CTCAE

A finding characterized by an unexpected or abnormal increase in overall body weight; for pediatrics, greater than the baseline growth curve.


Grade 4 Esophageal Ulcer, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Urostomy Obstruction, CTCAE

Death


Refractory Acute Graft Versus Host Disease

Acute graft versus host disease that is resistant to treatment.


Grade 4 Constipation, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Injury of upper respiratory tract

Mechanical or chemical injuries to the upper airways, including trachea, pharynx and larynx.


Childhood Anaplastic Oligodendroglioma

An anaplastic oligodendroglioma that arises from the central nervous system and occurs during childhood.


Refractory Uterine Corpus Cancer

Uterine corpus cancer that is resistant to treatment.


Grade 3 Anal Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated


Grade 3 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IVA Cervical Cancer FIGO 2018

The cervical carcinoma has spread to adjacent pelvic organs. (FIGO 2018)


Grade 1 Ileum Stricture or Stenosis, CTCAE


Grade 2 Rash Hand or Foot Skin Reaction, CTCAE


Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Bronchospasm, CTCAE

A disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall.


Grade 3 Nasal Cavity Intra-Operative Injury, CTCAE


Grade 3 Parathyroid Intra-Operative Injury, CTCAE


Grade 3 Rectal Fistula, CTCAE

Invasive intervention indicated


Unresectable Digestive System Neuroendocrine Tumor G2

Digestive system neuroendocrine tumor G2 that is not amenable to surgical resection.


Incontinent Epispadias

Epispadias with urinary incontinence.


Acute Myeloid Leukemia with Variant MLL Translocations

A term referring to acute myeloid leukemias with rearrangement of the MLL gene which results in translocations with various genes other than the MLLT3 (AF9) gene.


Chylous Ascites, CTCAE

A disorder characterized by accumulation of milky fluid in the peritoneal cavity.


Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Erythema Multiforme, CTCAE

Target lesions covering <10% BSA and not associated with skin tenderness


Gestational Trophoblastic Tumor by AJCC v7 Stage

A term that refers to the staging of gestational trophoblastic tumor according to the American Joint Committee on Cancer, 7th edition.


Grade 4 Urinary Tract NOS Intra-Operative Injury, CTCAE


Grade 4 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Intraoperative Respiratory Injury, CTCAE

Partial resection of injured organ/structure indicated


Sinus Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses.


Grade 3 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE