Grade 3 Pharyngolaryngeal Pain, CTCAE

Severe pain; limiting self care ADL


Childhood Acute Myeloid Leukemia Not Otherwise Specified

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Acute myeloid leukemias that occur in childhood and do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related.  This category includes entities classified according to the French-American-British classification scheme.


Cervical Blue Nevus

A nevus that arises from the cervix. It is characterized by the presence of benign, heavily pigmented dendritic melanocytes.


Grade 3 Bile Duct Stenosis, CTCAE

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Severely altered GI function; invasive intervention indicated


Grade 4 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Congenital Disruption

A morphologic defect of an organ, part of an organ, or a larger region of the body that results from the extrinsic breakdown of, or an interference with, an originally normal developmental process.


Transient Organic Mental Disorder

An organic mental disorder that is temporary in nature.


Elevated CA15-3

A laboratory test result indicating the presence of an increased level of the tumor-associated antigen (TAA) CA15-3 in a blood or serum sample.


Small Intestinal Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the intestinal contents of the small intestine.


Grade 5 Bronchopleural Fistula, CTCAE

Death


Grade 4 Atrial Flutter, CTCAE

Life-threatening consequences; embolus requiring urgent intervention


Atrial Septum Lipomatous Hypertrophy

A condition in which deposits of fat accumulate within the interatrial septum.


EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder

A clonal lymphoproliferative disorder that develops following an organ transplantation and is caused by Epstein-Barr virus infection.


Shared Neoantigen-Positive Malignant Solid Neoplasm

A malignant solid neoplasm that expresses unique tumor-specific neoantigens across a subset of patients.


Grade 1 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Radiation-Related Sarcoma

A sarcoma that arises in the bones or soft tissues following exposure to ionizing or non-ionizing radiation.


Recurrent Chronic Myelomonocytic Leukemia

The reemergence of chronic myelomonocytic leukemia after a period of remission.


Iron Overload, CTCAE

A disorder characterized by accumulation of iron in the tissues.


Appendix Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the appendix. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Grade 5 Rectal Necrosis, CTCAE

Death


Grade 1 Ileal Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Glucose Intolerance, CTCAE

Severe symptoms; insulin indicated


Grade 1 Prostatic Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Menorrhagia, CTCAE

A disorder characterized by abnormally heavy vaginal bleeding during menses.


Stage IA1 Cervical Cancer AJCC v9

Stage IA1 includes: T1a1, N0, M0. T1a1: Tumor with measured stromal invasion equal or less than 3 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 2 Duodenal Stenosis, CTCAE

Symptomatic; altered GI function


Grade 4 Hypertriglyceridemia, CTCAE

>1000 mg/dL; >11.4 mmol/L; life-threatening consequences


Grade 2 Urinary Tract Infection, CTCAE

Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 2 Confusion, CTCAE

Moderate disorientation; limiting instrumental ADL


Grade 2 Papilledema, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


Grade 3 Restlessness, CTCAE

Severe symptoms; limiting self care ADL


Advanced Gastric Neuroendocrine Carcinoma

A gastric neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Endocrine Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Connective and Soft Tissue Disorder

A non-neoplastic or neoplastic disorder that affects the connective and soft tissue.


Metastatic Proximal Gastric Adenocarcinoma

A proximal gastric adenocarcinoma that has spread from its original site of growth to another anatomic site.


Skin Basal Cell Carcinoma with Adnexal Differentiation

A basal cell carcinoma of the skin that is characterized by adnexal differentiation.


Central Nervous System Histiocytic and Dendritic Cell Neoplasm

A neoplasm that originates from histiocytes and accessory cells and affects the central nervous system.  It is usually associated with the presence of identical tumors outside the central nervous system.  Representative examples include Langerhans cell histiocytosis, histiocytic sarcoma, and follicular dendritic cell sarcoma.


Grade 5 Stroke, CTCAE

Death


Pharyngolaryngeal Pain

Painful sensation in the pharyngolaryngeal region.


Grade 3 Inferior Vena Cava Intra-Operative Injury, CTCAE


Breast Infection, CTCAE

A disorder characterized by an infectious process involving the breast.


Grade 5 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Uveitis, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Grade 2 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Metastatic Infiltrating Bladder Urothelial Carcinoma, Nested Variant

Bladder nested variant urothelial carcinoma that has spread to another anatomical site.


Perianal Squamous Intraepithelial Neoplasia

A precancerous neoplastic intraepithelial process involving the squamous epithelium of the perianal skin. Clinically, it usually presents as a white or red area in the perianal skin. Morphologically, it is characterized by full thickness dysplasia of the squamous epithelium and sometimes of the pilosebaceous epithelium. Human papillomavirus DNA sometimes may be identified in the dysplastic epithelium. It may recur after treatment, however only a small percentage of cases progress to squamous cell carcinoma.


Cholesterol High, CTCAE

A finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen.


Infectious Mediastinitis

An acute or chronic infectious process affecting the mediastinum.


Placenta, Retained

After delivery of neonate, placental retention that requires clinical intervention such as manual extraction, curettage or uterotonic medications.


Road Injury

An injury that occurs on a road or motor way.


Grade 1 Neck NOS Intra-Operative Injury, CTCAE


Grade 3 Vaginal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 Peripheral Nerve Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Salivary Gland Intra-Operative Injury, CTCAE


Elevated Urine Alkaline Phosphatase

An elevated concentration of alkaline phosphatase in the urine.


Infratentorial Glioblastoma

A glioblastoma that occurs in the infratentorial region.


Malignant Lymphoma Follicular, Large Cleaved Cell Type


Juvenile Absence Epilepsy

A subtype of idiopathic generalized epilepsy, whose manifestations occur around puberty, associated with mutation(s) in the EFHC1 gene, encoding EF-hand domain-containing protein 1.


Scrotal Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the scrotal area.


Grade 5 Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Urine Output Decreased, CTCAE

A finding based on test results that indicate urine production is less relative to previous output.


Congenital Abnormalities of Erythrocyte Differentiation or Function

Inherited disorders involving abnormalities of red blood cell function, structure, or production. Some diseases in this group may be associated with bone marrow failure, neutropenia, and/or thrombocytopenia.


Utricle-Associated Mucosal Gland Hyperplasia

A benign microacinar proliferation occurring exclusively in the area of the utricle.


Acquired Cytomegaloviral Infection

An infection with the Cytomegalovirus that is not present from birth.


Grade 2 Small Intestine Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Biliary System Disorder

A non-neoplastic or neoplastic disorder that affects the intrahepatic or extrahepatic bile ducts or the gallbladder. Representative examples of non-neoplastic disorders include cholangitis and cholecystitis. Representative examples of neoplastic disorders include extrahepatic bile duct adenoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Increased Concomitant Drug Level

An increase in the level of a concomitant drug.


Adrenal Gland Hyperplasia II

Decreased activity of the enzyme 3-beta-hydroxysteroid dehydrogenase, associated with mutation(s) in the HSD3B2 gene. The lack of activity of this enzyme produces a type of congenital adrenal hyperplasia.


Grade 2 Skin Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Cranial Nerve IV Intra-Operative Injury, CTCAE


Grade 1 Intestinal Stoma Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Grade 3 Suicide Attempt, CTCAE

Suicide attempt or gesture without intent to die


Grade 3 Voice Changes and Dysarthria, CTCAE


Grade 3 Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Gastric Adenocarcinoma

Gastric adenocarcinoma that is resistant to treatment.


Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


Grade 5 Upper Aerodigestive Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Vaginal Cancer AJCC v6 and v7

Stage IV includes: IVA: (T4, Any N, M0) and IVB: (Any T, Any N, M1).  T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify tumor as T4).  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 6th and 7th eds.)


Grade 4 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Granuloma of conjunctiva

A granuloma located on the conjunctiva, usually involving the inner surface of the eyelid.


Grade 2 Forced Expiratory Volume Decreased, CTCAE

FEV1 60-69%


Terminal Hematuria

Gross hematuria that occurs at the end of, or immediately after voiding.


Grade 5 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Ileal Obstruction, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL; naso-gastric tube indicated


Unresectable Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma that is not amenable to surgical resection.


Prostatic Clear Cell Cribriform Hyperplasia

A rare type of prostatic hyperplasia. It is characterized by hyperplastic glandular cells with clear cytoplasm.


Unexpected Adverse Drug Reaction

An adverse drug reaction, whose nature, severity, specificity, or outcome is not consistent with the term or description used in the applicable product information (e.g., IB for an unapproved investigational product or PI/summary of product characteristics for an approved product, and/or scientific literature). (ICH)


Grade 4 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Induction Death

Death of the patient due to the toxic side effects of induction therapy.


Grade 5 Spinal Fracture, CTCAE

Death


Grade 4 Pelvis Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Abdomen Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Crushing injury

Traumatic compression of the body or a part of the body.


Grade 5 Other Hemorrhage and Bleeding, CTCAE


Grade 5 Esophageal Ulcer, CTCAE

Death


Grade 5 Colonic Fistula, CTCAE

Death


Metastatic Malignant Mesothelioma

Malignant mesothelioma that has spread from its original site of growth to another anatomic site.


Grade 2 Fever, CTCAE

>39.0-40.0 degrees C (102.3-104.0 degrees F)


Stage IA Fallopian Tube Cancer AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Fallopian tube cancer with tumor limited to fallopian tube surface; no malignant cells in ascites or peritoneal washings N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Increase in B-type Natriuretic Peptide or N-terminal pro-B-type Natriuretic Peptide

A finding of an increased amount of either B-type natriuretic peptide or N-terminal pro-B-type natriuretic peptide


Increased Drug AUC

Increased area under the plot of plasma concentration of a drug against time after drug administration.


Grade 3 Bronchus Infection with Unknown Absolute Neutrophil Count, CTCAE


Digestive System Small Cell Neuroendocrine Carcinoma

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant small cells.


Early Localized Lyme Disease

An early stage of Lyme disease that may present within 3-30 days after a tick bite with a red, concentrically-expanding rash (erythema migrans), fatigue, chills, fever, headache, muscle and joint aches, and swollen lymph nodes.


Receptor Status

Refers to the presence or absence of specific receptor molecules on the surface of a cells in a specimen.


Deficiency of vitamin D3

Abnormally low concentration of vitamin D3 (cholecalciferol) in the blood.


Grade 2 Radiation Excluding Chemoradiation, CTCAE


Stage IIIA Anal Cancer AJCC v8

Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Gastrointestinal Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 1 Ileal Ulcer, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Cranial Nerve III Neuropathy, CTCAE


Grade 4 Pleural Hemorrhage, CTCAE

Life-threatening consequences; intubation or urgent intervention indicated


Neonatal Culture Positive Sepsis, AE

An adverse event in a newborn characterized by a systemic inflammatory response to an infection with an identifiable cause.


Locally Advanced Small Cell Neuroendocrine Carcinoma

A small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 4 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Leukemia Secondary To Oncology Chemotherapy, CTCAE

Death


Grade 3 Alkaline Phosphatase Increased, CTCAE

>5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


Grade 2 Euphoria, CTCAE

Moderate mood elevation


Nutritional Calcium Deficient Rickets

Nutritional rickets due to dietary deficiency of calcium.


Grade 3 Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Hypogonadotropic Hypogonadism with Adrenal Hypoplasia Congenita

Hypogonadotropic hypogonadism with congenital adrenal hypoplasia associated with mutation(s) in the NR0B1 gene (on the X chromosome).


Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Adult Atypical Meningioma

An atypical meningioma that occurs during adulthood.


Grade 5 Hyperkalemia, CTCAE

Death


Grade 3 Hypokalemia, CTCAE

<3.0-2.5 mmol/L; hospitalization indicated


Grade 4 Lung Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


IgM Monoclonal Gammopathy

An abnormal laboratory test result indicating the presence of IgM monoclonal immunoglobulin in the blood or urine.


Stage IIIB Esophageal Adenocarcinoma AJCC v7

Stage IIIB includes: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 1 Pancreatic Duct Intra-Operative Injury, CTCAE


Grade 4 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Radiating Chest Pain Along Right Upper Sternal Border

The location of the radiating chest pain is along the right upper sternal border.


Death Related to Adverse Event

The termination of life associated with an adverse event.


Obstructed Megaureter

A megaureter in which there is obstruction to the flow of urine at the ureterovesical junction.


Grade 3 Uterine Fistula, CTCAE

Invasive intervention indicated


Secondary Graft Failure After Hematopoietic Cell Transplantation

Loss of donor hematopoietic cells following initial engraftment.


Grade 4 Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Grade 4 Colonic Ulcer, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Abdominal Distension, CTCAE

A disorder characterized by swelling of the abdomen.


Locally Advanced Large Cell Neuroendocrine Carcinoma

A large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 1 Lingual Nerve Intra-Operative Injury, CTCAE


Bone Marrow Hypocellular, CTCAE

A disorder characterized by the inability of the bone marrow to produce hematopoietic elements.


Hypoproteinemia

A laboratory test result indicating abnormally low levels of total protein in the serum.


Infusion Related Adverse Event

An adverse event that can be related to an infusion.


CTCAE v4 Grade 1

An adverse event that is asymptomatic; or involves mild or minor symptoms; or is of marginal clinical relevance; or consists of clinical or diagnostic observations alone; or for which intervention is not indicated; or for which only non-prescription intervention is indicated.


Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage II Centroblastic Follicular Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 5 Suicide Attempt, CTCAE

Death


Extrahepatic bile duct cancer stage II

Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invades the liver, gallbladder, pancreas, and/or unilateral branches or the portal vein (right or left) or hepatic artery (right or left).  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Grade 2 Lymph Node Pain, CTCAE

Moderate pain; limiting instrumental ADL


Breast hyperplasia

A general term that refers to hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, usual ductal hyperplasia, columnar cell hyperplasia, and atypical lobular hyperplasia.


Grade 2 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 5 Neonatal Sinus Bradycardia, AE

A sinus bradycardia adverse event in a newborn which results in death.


Blood Gonadotrophin Abnormal, CTCAE

A finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen.


Injury To Inferior Vena Cava, CTCAE

A finding of damage to the inferior vena cava.


Genitourinary Signs and Symptoms

Patient complaints (symptoms), physical or laboratory findings (signs) related to the genitourinary system.


Cranial Nerve III Intra-Operative Injury, CTCAE


Grade 3 Optic Nerve Disorder, CTCAE

Marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200)


Grade 4 Cardiac Arrest, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Personality and Behavioral Change, CTCAE


Grade 1 Colon Intra-Operative Injury, CTCAE


Grade 2 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Nickel Metabolic Disorder

A storage disorder that results from impaired metabolism of nickel.


Recurrent Polymorphous Low Grade Neuroepithelial Tumor of the Young

The reemergence of polymorphous low-grade neuroepithelial tumor of the young after a period of remission.


Grade 3 Hypernatremia, CTCAE

>155-160 mmol/L; hospitalization indicated


Grade 1 Alopecia, CTCAE

Hair loss of <50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage


Passive Smoke Exposure

Exposure to tobacco smoke products among individuals who do not smoke. This can result from sharing space with a smoker or from placental transfer from mother to fetus.


Rectum Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Rectal Ulcer, CTCAE

Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea)


Malignant neoplasm of bladder recurrent

The reemergence of a malignant bladder neoplasm after a period of remission.


Philadelphia chromosome negative chronic myelogenous leukemia

A chronic myelogenous leukemia which does not have the characteristic t(9;22)(q34;q11.2) translocation but it has either a variant translocation or a cryptic translocation that can not be detected by conventional cytogenetic analysis.  In such cases the BCR-ABL1 fusion gene is always detected by RT-PCR, FISH, or Southern blot analysis.


Grade 5 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Gastrointestinal carcinoma in situ

An intraepithelial carcinoma arising from any part of the digestive system without evidence of invasion.


Urostomy Prolapse

Displacement of the urostomy.


Lumbar Meningocele

A congenital abnormality in the lumbar region of the spine in which the meninges protrude through a defect in the spinal column.


Grade 4 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Venous Injury, CTCAE

Symptomatic (e.g., claudication); repair or revision not indicated


Clinical Stage 0 Cutaneous Melanoma AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Primary Cutaneous Mucinous Carcinoma

A rare low-grade carcinoma of the sweat glands. The most common sites are eyelids, scalp, axilla, face and trunk. It is histologically characterized by proliferating ducts until the overproduction of mucin creates islands of tumor cells, essentially floating in mucinous pools (Rosai J. Ackerman's Surgical Pathology).


Unresectable Vulvar Squamous Cell Carcinoma

Vulvar squamous cell carcinoma that is not amenable to surgical resection.


Grade 2 Colonic Perforation, CTCAE

Invasive intervention not indicated


Grade 5 Small Intestinal Mucositis, CTCAE

Death


Grade 2 Pharyngeal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Lupus encephalitis

Encephalitis that is associated with systemic lupus erythematosus.


Childhood depression

Similar to depression in adults, childhood depression is characterized by a prolonged depressed or irritable mood accompanied by a significant loss of interest in activities, changes in appetite or sleep, decreased energy, feelings of worthlessness, and/or recurrent thoughts of death or suicide.


Grade 5 Radiation Excluding Chemoradiation, CTCAE


Grade 3 Ovarian Rupture, CTCAE

Transfusion; invasive intervention indicated


Stage IIB Esophageal Carcinoma

Stage IIB includes: For squamous cell carcinoma: (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Grade 5 Right Ventricular Dysfunction, CTCAE

Death


Ovarian Rupture, CTCAE

A disorder characterized by tearing or disruption of the ovarian tissue.


Congenital spondylolysis

Spondylolysis, the cause of which is present from birth.


Grade 3 Folliculitis, CTCAE

>30% BSA; systemic intervention indicated


Acute Leukemia of Ambiguous Lineage, Not Otherwise Specified

Acute leukemia of ambiguous lineage, expressing combinations of markers that do not allow for its classification as either acute undifferentiated leukemia or mixed phenotype acute leukemia, and definitive classification along a single lineage is difficult. (WHO 2017)


Vascular Disorders - Other, Specify, CTCAE


Unresectable Esophageal Carcinoma

A carcinoma that arises from the esophagus and is not amenable to surgical resection.


Papillary mucinous cystadenocarcinoma

An invasive adenocarcinoma characterized by cystic changes, papillary growth pattern, and the presence of malignant glandular cells which contain intracytoplasmic mucin.


Metastatic Primary Malignant Brain Neoplasm

A malignant neoplasm that arises from the brain and has spread from its original site of growth to other sites.


Gastric Hepatoid Adenocarcinoma

A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of large polygonal malignant cells with eosinophilic cytoplasm resembling hepatocytes.


Anal squamous cell carcinoma metastatic

Anal squamous cell carcinoma that has spread from its primary site to another anatomic site.


Recurrent Endometrial Clear Cell Adenocarcinoma

The reemergence of endometrial clear cell adenocarcinoma after a period of remission.


Bone Sarcoma by AJCC v7 Stage

A term that refers to the staging of bone sarcoma, following the rules of the TNM AJCC v7 classification system.


CTRP Clinical Finding

A finding concept that has been requested by CTRP to be used in the disease field for abstraction and search of clinical trials.


Pulmonary Hypertension, CTCAE

A disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder.


Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Hydrocephalus, CTCAE

A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain.


Diffuse neurofibroma

A rare neurofibroma with an infiltrative growth pattern.  It involves the skin and subcutaneous tissue and grows in a plaque-like fashion.  Malignant transformation is rare.


Gastric Carcinoma with Lymphoid Stroma

A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of prominent lymphocytic stromal infiltration and poorly formed tubular structures.


Grade 2 Prostatic Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


This entity includes cases that have clinical, laboratory, and morphologic features that support the diagnosis of both a myelodysplastic syndrome and a myeloproliferative neoplasm, but do not meet the criteria for any of the other entities included in the myelodysplastic/myeloproliferative neoplasm category.  (WHO, 2001)


Naevus spider acquired

A non-congenital, benign vascular lesion with a central punctum (arteriole) that is surrounded by thin-walled capillaries in a radial pattern. It occurs as the result of the dilatation of pre-existing vessels and is most often an incidental finding. The lesion may also be found in association with hypermetabolic states or chronic disease.


Metastatic Malignant Neoplasm in the Pelvic Cavity

The spread of a malignant neoplasm from a primary site to the pelvic cavity.


Hypertension, CTCAE

A disorder characterized by a pathological increase in blood pressure.


Grade 4 Papilledema, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Refractory Acute Undifferentiated Leukemia

Acute undifferentiated leukemia that does not respond to treatment.


Stage IV Urethral Cancer AJCC v8

Stage IV includes: (T4, N0, M0); (T4, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: For male penile urethra and female urethra: Tumor invades other adjacent organs (e.g., invasion of the bladder wall). For prostatic urethra: Tumor invades other adjacent organs (e.g., extraprostatic invasion of the bladder wall, rectal wall). N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. N2: Multiple regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Grade 4 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Movements Involuntary, CTCAE

Severe symptoms; limiting self care ADL


Grade 2 Duodenal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Skin disorder arising from mental factors

A skin disorder for which mental factors play a causative role.


Virus-Related Carcinoma

Carcinoma that develops in the context of an individual infected with a virus.


Vulvar Melanocytic Nevus

A benign, atypical, or dysplastic melanocytic nevus that arises from the vulva.


Enterotoxigenic E coli Infection

A pathotype of Escherichia coli, which is a gram-negative bacteria that is transmitted through the fecal-oral route. It has an incubation period of 10-72 hours and a duration of 1-5 days. Symptoms may include acute, occasionally severe diarrhea without fever.


Radiculitis, CTCAE

A disorder characterized by inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root.


Grade 5 Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


Grade 3 Accessory Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Grade 1 Proctitis, CTCAE

Rectal discomfort, intervention not indicated


Grade 2 Pelvic Pain, CTCAE

Moderate pain; limiting instrumental ADL


Complete Atrioventricular Canal Defect Balanced

Atrioventricular septal defect in which the atrioventricular junction is shared evenly between the left ventricle and right ventricle.


Grade 1 Other Metabolic and Laboratory, CTCAE


Liver and Intrahepatic Bile Duct Benign Non-Epithelial Neoplasm

A benign non-epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts.  Representative examples include hemangioma, angiomyolipoma, and solitary fibrous tumor.


Cognitive Disturbance, CTCAE 5.0

A disorder characterized by a conspicuous change in cognitive function.


Gastrointestinal Stoma Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the gastrointestinal tract stoma.


Endometrioid intraepithelial neoplasia

A neoplastic clonal expansion of endometrial glands characterized by cytologic changes of the epithelium and the presence of an increased number of endometrial glands. The glands form crowded aggregates with tubular or branching patterns which are cytologically distinct from the background architectural and cytological pattern. It is associated with molecular changes seen in endometrioid endometrial carcinoma, including microsatellite instability, PAX2 inactivation, and PTEN, KRAS, and CTNNB1 gene mutations.


High Leukocyte Count

A higher than average level of leukocytes in a sample.


AIDS-Related Malignant Cervical Neoplasm

A malignant neoplasm that arises from the cervix in a patient with acquired immunodeficiency syndrome. This category includes cervical carcinoma, Kaposi sarcoma, and non-Hodgkin lymphoma.


Pericarditis secondary to uremia

Inflammation of the pericardium associated with chronic kidney failure.


Grade 1 Nasopharynx Intra-Operative Injury, CTCAE


Refractory Chronic Leukemia

Chronic leukemia that is resistant to treatment.


Grade 4 Endocarditis Infective, CTCAE

Life-threatening consequences; urgent intervention indicated


Adverse Event Associated with Constitutional Symptoms


Testicular cancer metastatic

A malignant germ cell tumor that arises from the testis and has spread to another anatomic site.


Non-Functioning Pancreatic Neuroendocrine Tumor G1

A low grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. It is characterized by the absence of a hormone-related clinical syndrome.


Grade 3 Carbon Monoxide Diffusion Capacity, CTCAE


Urostomy Leak, CTCAE

A finding of leakage of contents from a urostomy.


Arterial Thrombosis Related to Vascular Access Complication

The formation of a thrombus in the artery as a direct result of an activity associated with vascular access.


Lugano Classification Stage I Hodgkin Lymphoma AJCC v8

Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Malignant Osteoclastic Giant Cell-Rich Tumor of Bone

A giant cell tumor that arises from the bone and is characterized by the presence of a malignant cellular component.


Neonatal Hypotension, AE

An adverse event in a newborn characterized by abnormally low blood pressure, which is usually symptomatic.


Refractory Sclerodermatous Graft Versus Host Disease

Sclerodermatous Graft Versus Host Disease that is resistant to treatment.


Grade 4 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Grade 1 Photophobia, CTCAE

Symptomatic but not limiting ADL


Infectious Encephalomyelitis

An infectious process that affects the brain and spinal cord tissues. It is usually caused by viruses.


Acral nevus

A melanocytic nevus that arises from the palms, soles, and nails.


Grade 1 Vaginal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 5 Arachnoiditis, CTCAE

Death


Grade 3 Prolapse of Urostomy, CTCAE

Dysfunctional stoma; elective operative intervention or major stomal revision indicated


Grade 3 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IIA2 Cervical Cancer AJCC v8

Stage IIA2 includes: T2a2, Any N, M0. T2a2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Cranial Nerve X Intra-Operative Injury, CTCAE


Liver Germ Cell Tumor

A benign or malignant extragonadal germ cell tumor that arises from the liver. Representative examples include teratoma and yolk sac tumor.


Loss of INI 1 Protein Expression

An immunohistochemical finding indicating negative staining of tumor cells for INI 1 protein, resulting from the inactivation of the INI 1 tumor suppressor gene.


Grade 2 Dysesthesia, CTCAE

Moderate sensory alteration; limiting instrumental ADL


Grade 2 Bronchopulmonary Dysplasia, AE

An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND need for 22-30% oxygen at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; need for 22-30% oxygen by 56 days postnatal age in infants born greater than 32 weeks' gestation; need for 22-30% oxygen at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


Refractory Fallopian Tube Mucinous Adenocarcinoma

Fallopian tube mucinous adenocarcinoma that is resistant to treatment.


Borrelia Burgdoferi-Associated Cutaneous Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

Primary cutaneous marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from chronically stimulated lymphoid tissue in the skin in response to Borrelia burgdoferi infection.


Indirect Contact Transmission Infection

Infection transmitted by water, food or other means of conveyance.


Interstitial Disease

A disease occurring chiefly in the connective-tissue framework of an organ.


Grade 4 Peritoneal Cavity Intra-Operative Injury, CTCAE


Grade 1 Neonatal Fever, AE

An adverse event in a newborn characterized by isolated, not sustained fever, no change in baseline age-appropriate behavior.


Grade 3 Breast Volume and Hypoplasia, CTCAE


Adolescent Gynecomastia

Gynecomastia that occurs during puberty and is not due to exogenous substances or disease processes.


Anal Canal Cancer by AJCC v6 and v7 Stage

A term that refers to the staging of anal canal cancer according to the American Joint Committee on Cancer, 6th and 7th editions. This staging system applies to carcinomas arising in the anal canal only; melanomas, carcinoid tumors, sarcomas, and perianal tumors are not included. (from AJCC 6th and 7th Eds.)


Grade 5 Perforation Bile Duct, CTCAE

Death


Chest Pain in Right Fifth Intercostal Space

The location of the chest pain is within the fifth intercostal space on the right side.


Mural Nodule

A solid, sharply demarcated, benign or malignant nodular mass that is attached to the wall of an organ.


Renal lymphocele

Encapsulated collection of lymphatic fluid around a transplanted kidney.


Periorbital Infection, CTCAE

A disorder characterized by an infectious process involving the orbit of the eye.


Refractory T Acute Lymphoblastic Leukemia

T-acute lymphoblastic leukemia that does not respond to treatment.


Human Papillomavirus-Related Vaginal Adenocarcinoma

An adenocarcinoma that arises from the vagina and is caused by human papillomavirus infection.


Metastatic Acral Lentiginous Melanoma

Acral lentiginous melanoma that has spread from its original site of growth to another anatomic site.


Unresectable Solid Neoplasm

A solid neoplasm that is not amenable to surgical resection.


Grade 2 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Testicular Hemorrhage, CTCAE

Death


Radiation burn

A burn caused by exposure to x-ray, radium, sunlight, atomic or any other type of radiant energy.


Grade 2 Skin Ulceration, CTCAE

Combined area of ulcers 1-2 cm; partial thickness skin loss involving skin or subcutaneous fat


Grade 3 Abdominal Distension or Bloating, CTCAE


Recurrent HIV-Related Lymphoproliferative Disorder

The reemergence of HIV-associated lymphoproliferative disorder after a period of remission.


Testicular Spermatocytic Tumor with Sarcoma

A malignant germ cell tumor that arises from the testis and is characterized by the presence of a spermatocytic tumor component that is contiguous with an undifferentiated or differentiated sarcomatous component.  It usually presents as a slowly growing mass that enlarges very rapidly soon after the initial diagnosis.


Myocardial Infarction, CTCAE

A disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area.


Toxic Epidermal Necrolysis, CTCAE

A disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.


Metastatic Gastric Neuroendocrine Carcinoma

A gastric neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site.


Progesterone Receptor Expressing Malignant Neoplasm

A malignant neoplasm that is positive for progesterone receptors.


Rhinorrhea, CTCAE

A disorder characterized by excessive mucous secretions draining from the nose.


Locally Advanced Digestive System Carcinoma

Digestive system carcinoma that has spread to nearby tissues or lymph nodes.


Grade 1 Gastroparesis, CTCAE

Mild nausea, early satiety and bloating, able to maintain caloric intake on regular diet


Arterial Thromboembolism, CTCAE

A disorder characterized by occlusion of an arterial vessel by a blood clot that develops in an artery.


Grade 5 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 3 Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Bacteremia, CTCAE

Blood culture positive with no signs or symptoms


Grade 4 Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Urostomy Site Bleeding, CTCAE

Transfusion indicated; invasive intervention indicated


Refractory Low Grade Fallopian Tube Serous Adenocarcinoma

Low grade fallopian tube serous adenocarcinoma that is resistant to treatment.


Grade 4 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Refractory Malignant Urinary System Neoplasm

Malignant urinary system neoplasm that is resistant to treatment.


Grade 1 Superior Vena Cava Vein Injury, CTCAE


Grade 2 Retina Intra-Operative Injury, CTCAE


Grade 4 Biliary Tree NOS Intra-Operative Injury, CTCAE


Grade 2 Hematoma, CTCAE

Minimally invasive evacuation or aspiration indicated


Grade 5 Bronchus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Adrenal Gland Intra-Operative Injury, CTCAE


Signet Ring Melanoma

A rare variant of cutaneous melanoma, characterized by the presence of malignant cells with signet-ring morphology.


Junctional melanocytic nevus of skin

A nevus characterized by the presence of an intraepidermal proliferation of nevus cells. The nevus cells form multiple nests in the dermal-epidermal junction. It presents as a small, slightly raised, pigmented skin lesion.


Mucosal lentiginous melanoma

An acral lentiginous melanoma affecting mucosal surfaces.


Grade 2 Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Dental-Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Adult Grade III Meningioma

A grade III meningioma that occurs during adulthood.


Grade 4 Infective Myositis, CTCAE

Life-threatening consequences; urgent intervention indicated


Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade I Meningioma

A benign meningioma which may recur in approximately 7-20% of the cases.  This category includes the angiomatous meningioma, fibrous meningioma, lymphoplasmacyte-rich meningioma, meningothelial meningioma, metaplastic meningioma, microcystic meningioma, psammomatous meningioma, secretory meningioma, and transitional meningioma.


Stage II Vulvar Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 5 Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Watering Eyes, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Phantom Limb Syndrome

Paresthesia or discomfort experienced post-amputation.


Recurrent Laryngeal Nerve Paralysis

Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis.


Grade 2 Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Tracheal Stenosis, CTCAE

Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


Recurrent Central Nervous System Lymphoma

The reemergence of central nervous system lymphoma after a period of remission.


Grade 2 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Heart Intra-Operative Injury, CTCAE


Esophageal Ulcer, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the esophageal wall.


Grade 3 INR Increased, CTCAE

>2.5; >2.5 x baseline if on anticoagulation; bleeding


Kidney Paraganglioma

An extremely rare paraganglioma that arises from the renal hilum. Paragangliomas that arise from the perihilar sympathetic ganglia are not included in this category.


Digestive System Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


High Grade Prostatic Intraepithelial Neoplasia, Mucinous Variant

High grade prostatic intraepithelial neoplasia characterized by the presence of masses of mucin within the affected distended glands.


Grade 1 Otitis External Ear Non Infectious, CTCAE


Grade 2 Lower Extremity Artery Injury, CTCAE


Malignant neoplasm of stomach recurrent

The reemergence of a malignant neoplasm of the stomach after a period of remission.


Stage I Cervical Cancer AJCC v8

Stage I includes: T1, Any N, M0. T1: Tumor confined to uterus (extension to corpus should be disregarded). M0: No distant metastasis. (AJCC 8th Ed.)


Blastic Granulocytic Sarcoma

A granulocytic sarcoma composed primarily of myeloblasts (WHO 2001).


Lobular Endocervical Glandular Hyperplasia

Lobular proliferations of benign-appearing small to moderate sized endocervical glands in the inner half of the cervical stroma. The glands are lined by columnar epithelial cells which contain pyloric gland-type mucin. There is minimal atypia and mitotic figures are rare. Some cases have been associated with adenocarcinoma in situ/high grade cervical glandular intraepithelial neoplasia and gastric-type adenocarcinomas.


Grade 4 Duodenum Intra-Operative Injury, CTCAE


Grade 3 Genitourinary Stoma Prolapse, CTCAE


Grade 1 Toothache, CTCAE

Mild pain


Grade 3 Stenosis of Gastrointestinal Stoma, CTCAE

Severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated


Grade 1 Ovarian Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Ventricular Tachycardia, CTCAE 5.0

A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates distal to the bundle of His.


Grade 1 Scleral Necrosis and Melt, CTCAE


Stage II Pancreatic Cancer AJCC v8

Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Pituitary hemorrhage

Bleeding within the pituitary gland.


Radiation-Related Osteosarcoma

A high grade osteosarcoma arising in an irradiated bone.


recurrent adult acute myeloid leukemia

The reemergence of acute myeloid leukemia in adults after a period of remission.


No Specific Molecular Profile Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by the absence of POLE gene mutations, mismatch repair (MMR) deficiency, and p53 gene mutations.


Pancreatic Intraductal Neoplasms

A group of cystic or mass-forming epithelial neoplasms that arise from the exocrine pancreas, exhibit ductal differentiation, and grow mostly within the pancreatic ducts.  This group includes the pancreatic intraductal papillary mucinous neoplasms and the pancreatic intraductal tubulopapillary neoplasms.


Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Great vessel abnormalities

A congenital vascular abnormality that affects the great vessels and/or aortic arch. Representative examples include double aortic arch, aortic coarctation, and absence of a pulmonary artery.


Grade 1 Neutrophil Count Decreased, CTCAE

<LLN-1500/mm3; <LLN-1.5 x 10e9/L


Stage I Appendix Carcinoma AJCC v7

Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Radiation-Induced Vascular Disease

A vascular disease caused by radiation.


Grade 3 Colonic Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated


Grade 3 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 4 Ejection Fraction Decreased, CTCAE

Resting ejection fraction (EF) <20%


Second degree perineal laceration

Injury to perineum involving perineal muscles but not involving anal sphincter. (reVITALize)


Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8

Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Hypertriglyceridemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood.


Grade 5 Genitourinary Stoma Stricture or Stenosis, CTCAE


Grade 3 Lens Intra-Operative Injury, CTCAE


Recurrent Gangliocytoma

The reemergence of gangliocytoma after a period of remission.


Low Weight Gain in Pregnancy

In a woman with a normal weight pre-pregnancy body mass index (BMI), i.e. 18.5-24.9, the weight gained during pregnancy does not exceed a total weight gain of 25 lbs. In a woman with an underweight pre-pregnancy body mass index (BMI), i.e. less than 18.5, the weight gained during pregnancy does not exceed a total weight gain of 28 lbs. In a woman with an overweight pre-pregnancy body mass index (BMI), i.e. 25.0-29.9, the weight gained during pregnancy does not exceed a total weight gain of 15 lbs. In a woman with an obese pre-pregnancy body mass index (BMI), i.e. greater than 30, the weight gained during pregnancy does not exceed a total weight gain of 11 lbs. These standards are supported for the whole population irrespective of height, race or ethnicity.


Gallbladder Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The Ki-67 index is higher than 20%.


Blood coagulation disorder due to liver disease

A disorder of blood clotting that is attributable to a deficiency in liver function.


Atrial Fibrillation, CTCAE

A disorder characterized by a dysrhythmia without discernible P waves and an irregular ventricular response due to multiple reentry circuits. The rhythm disturbance originates above the ventricles.


Pathological Gynecomastia

Gynecomastia that is due to exogenous substances or disease processes.


Grade 1 Uveitis, CTCAE

Anterior uveitis with trace cells


Grade 2 Obstruction Gastric, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Pedunculated conjunctival papilloma

A papilloma that arises from the conjunctival squamous epithelium. It is associated with human papillomavirus infection.


Benign Intracranial Neoplasm

A benign neoplasm involving the intracranial area.


Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Dysphagia, CTCAE

A disorder characterized by difficulty in swallowing.


Neonatal Coagulation Disorder, AE

An adverse event in a newborn characterized by abnormal blood clotting or bleeding.


Grade 4 Duodenal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


Chronic Insomnia

Insomnia that has persisted at least one month.


Grade 1 Libido Decreased, CTCAE

Decrease in sexual interest not adversely affecting relationship


Grade 5 Stevens-Johnson Syndrome, CTCAE

Death


New Onset Diabetes After Transplant

Development of diabetes after transplant, usually associated with calcineurin inhibitor use.


Grade 4 Other Allergy and Immunology, CTCAE


Localized Prostate Carcinoma

A carcinoma that arises from the prostate and has not spread to other anatomic sites.


Benign Ovarian Partly Luteinized Thecoma


Metastatic Malignant Nongerminomatous Germ Cell Tumor

A malignant nongerminomatous germ cell tumor that has spread from its original site of growth to another anatomic site.


Grade 1 Associated with the Teeth, CTCAE


Recurrent Meningioma

The reemergence of a meningioma after a period of remission.


Grade 2 Abdominal Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Upper Gastrointestinal Hemorrhage NOS, CTCAE


Well Differentiated Malignant Neoplasm

A neoplasm whose histologic characteristics are similar to the tissue from which it arose.


Grade 2 Atelectasis, CTCAE

Symptomatic (e.g., dyspnea, cough); medical intervention indicated (e.g., chest physiotherapy, suctioning); bronchoscopic suctioning


Myelodysplastic syndrome with ring sideroblasts and multilineage dysplasia

A myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia, dysplastic changes in 10% or more of the cells in two or more of the myeloid cell lines, and 15% or more ring sideroblasts in the bone marrow.  (WHO, 2001)


Ampulla of Vater Neuroendocrine Neoplasm

A neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Grade 5 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


Grade 2 Upper Extremity Intra-Operative Injury, CTCAE


Grade 2 Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ovarian Leydig Cell Hyperplasia

An increased number of Leydig cells in the hilar region of the ovary. (WHO 2020)


Grade 4 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Stomach Intra-Operative Injury, CTCAE


Grade 5 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Cardiac Troponin T Increased, CTCAE

Levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer


Grade 3 External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Merkel Cell Carcinoma AJCC v7

Stage IV includes: Any T, Any N, M1.  M1: Metastasis beyond regional lymph nodes. (AJCC 7th Ed.)


Stage 0 Anal Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: High-grade squamous intraepithelial lesion (previously termed carcinoma in situ, Bowen disease, anal intraepithelial neoplasia II-III, high-grade anal intraepithelial neoplasia). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Endometrial Carcinoma

A carcinoma that arises from the endometrium and has metastasized to another anatomic site.


Grade 5 Prostate Infection, CTCAE

Death


Grade 2 Irritability, CTCAE

Moderate; limiting instrumental ADL; increased attention indicated


Grade 3 Soft Tissue Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 1 Hyperglycemia, CTCAE

Abnormal glucose above baseline with no medical intervention


Salivary Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Cranial Nerve X Intra-Operative Injury, CTCAE


Grade 1 Glucosuria, CTCAE

Present


Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma


Grade 3 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Tremor, CTCAE

Moderate symptoms; limiting instrumental ADL


Digestive System Hodgkin Lymphoma

A Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site.


Refractory Skin Squamous Cell Carcinoma

Skin squamous cell carcinoma that does not respond to treatment.


Simple Hamartoma of the Retinal Pigment Epithelium

A retinal hamartoma that involves only the retinal pigment epithelium. (WHO 2018)


Extragonadal primary germ cell tumor mixed stage II


Refractory Myxoid Liposarcoma

Myxoid liposarcoma that does not respond to treatment.


Esophageal Adenocarcinoma by AJCC v7 Stage

A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 7th edition.


Grade 5 Delusions, CTCAE

Death


Subcutaneous Disorder

A disorder of the subcutaneous tissue.


Undersocialized conduct disorder, aggressive type


Locally Advanced Biliary Tract Carcinoma

Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread to nearby tissues or lymph nodes.


Radiating Chest Pain Along Left Midclavicular Line

The location of the radiating chest pain is along the left midclavicular line.


Refractory Endometrial Transitional Cell Carcinoma

Endometrial transitional cell carcinoma that is resistant to treatment.


Recurrent Appendix Carcinoma

The reemergence of appendix carcinoma after a period of remission.


Kidney Schwannoma

A rare schwannoma arising from the kidney.


Grade 4 Postoperative Thoracic Procedure Complication, CTCAE

Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Treatment-Emergent Adverse Event

A situation that emerges during treatment, having been absent pretreatment, or worsens relative to the pretreatment state. (ICH)


Congenital complete heart block

A disorder characterized by an electrocardiographic finding of a complete atrioventricular block that manifests during fetal life or soon after birth. It may be isolated or associated with other congenital heart defects. Isolated congenital complete atrioventricular block may be associated with maternal connective tissue disorders.


Appendix Neuroendocrine Tumor by AJCC v7 Stage

A term that refers to the staging of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


Grade 1 CD4 Lymphocytes Decreased, CTCAE

<LLN-500/mm3; <LLN-0.5 x 10e9/L


Lugano Classification Stage IE Childhood Hodgkin Lymphoma AJCC v8

Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Grade 4 Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Vital Capacity Abnormal, CTCAE

<75-50% of predicted value; limiting instrumental ADL


Metaplastic meningioma

A WHO grade I meningioma characterized by the presence of a prominent mesenchymal component. The mesenchymal component may be osseous, cartilaginous, myxoid, lipomatous, or a mixture of mesenchymal elements.


Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8

Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Bone Cancer AJCC v7

Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Small Bowel Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 5 Meningismus, CTCAE

Death


Grade 5 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Obstruction Gastric, CTCAE

Hospitalization indicated; invasive intervention indicated; limiting self care ADL


Decreased Carbon Monoxide Diffusing Capacity

A lung function test result in which the lung capacity to absorb carbon monoxide is decreased.


Grade 3 Anal Necrosis, CTCAE

TPN or hospitalization indicated; invasive intervention indicated


Grade 5 Hyponatremia, CTCAE

Death


Grade 2 Surgical and Medical Procedures - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Joint Tuberculosis

Tuberculosis affecting a joint.


Grade 4 Other Blood and Bone Marrow, CTCAE


Ureter Cancer by AJCC v7 Stage

A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 7th edition.


Grade 5 Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Elevated WT1

A finding indicating elevated concentrations of WT1 in a sample.


Epidermal burn of skin

A painful injury to the epidermis due to chemical, friction, radiation or thermal exposure. The affected area appears red and blanches when touched.


Grade 5 Capillary Leak Syndrome, CTCAE

Death


Foregut Neuroendocrine Tumor G1

A carcinoid tumor that arises from the lung, thymus, esophagus, stomach, or duodenum.


Radiating Chest Pain in Left Arm

The location of the radiating chest pain is in the left arm.


Stage IIIA Gallbladder Cancer AJCC v7

Stage IIIA includes: T3, N0, M0. T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Polycythaemia (excl rubra vera)

An increase in the concentration of red blood cells (hemoglobin) that is not caused by polycythemia vera.


Grade 5 Stomach Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Other Blood and Bone Marrow, CTCAE


Stage IIIC Uterine Corpus Cancer AJCC v8

Stage IIIC includes: IIIC1: T1-T3, N1/N1mi/N1a, M0; IIIC2: T1-T3, N2/N2mi/N2a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2mi: Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


Grade 5 Ventricular Arrhythmia, CTCAE

Death


Thrombotic microangiopathy that presents in some patients undergoing hematopoietic stem cell transplantation (HSCT). Though similar in presentation to thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS), transplant-associated thrombotic microangiopathy (TA-TMA) is a distinct disorder. Several risk factors may be associated with TA-TMA, including high-dose chemotherapy, radiation therapy, HLA mismatch, use of calcineurin inhibitors, acute graft-versus-host disease (GVHD), and infections.


Corneal dellen

Corneal thinning just anterior to the limbus secondary to abnormal and/or irregular bulbar conjunctival contour.


Chest Pain in Left Fourth Intercostal Space

The location of the chest pain is within the fourth intercostal space on the left side.


Spindle cell melanoma, type B

A melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli. Representative example is the type B spindle cell uveal melanoma.


Grade 1 Soft Tissue NOS Intra-Operative Injury, CTCAE


Esophageal Adenocarcinoma by AJCC v8 Stage

A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


asymptomatic carrier of alpha-thalassemia

A condition in which a person has reduced protein production from one of the four alpha-globin alleles.


Stage IIIC Cervical Cancer FIGO 2018

Cervical carcinoma with involvement of pelvic and/or para-aortic lymph nodes, irrespective of tumor size and extent (with r and p notations). (FIGO 2018)


Grade 2 Breast Intra-Operative Injury, CTCAE


Recurrent Severe Aplastic Anemia

The reemergence of severe aplastic anemia after a period of remission.


Recurrent Pancreatic Neuroendocrine Carcinoma

The reemergence of pancreatic neuroendocrine carcinoma after a period of remission.


Grade 2 Genital Edema, CTCAE

Readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour


Grade 4 Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Renal and Urinary Disorders - Other, Specify, CTCAE


Grade 3 Bronchospasm and Wheezing, CTCAE


Grade 4 Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Rectal Fissure, CTCAE

Asymptomatic


Stage II Cervical Cancer FIGO 2018

The cervical carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall. (FIGO 2018)


Grade 4 Neonatal Spontaneous Intestinal Perforation, AE

A spontaneous intestinal perforation (SIP) adverse event in a newborn characterized by life-threatening consequences (e.g. shock, organ failure); urgent intervention indicated.


Obstructed femoral hernia

The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis.


Thrombotic Thrombocytopenic Purpura, CTCAE

A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition.


Restenosis

The reoccurrence of stenosis after it has been treated.


Tuberculosis disease that is caused by a pre-extensively drug-resistant strain of Mycobacterium tuberculosis.


Grade 1 Upper Gastrointestinal Hemorrhage NOS, CTCAE


Vascular Access Device Complications

Difficulties related to an apparatus used to gain access to arteries and veins.


Subpleural Nodule

A nodule that is directly underlying a pleural surface though there may be separation between the nodule margin and pleura.


Non-Neoplastic Pancreatic Disorder

A non-neoplastic disorder that affects the pancreas. Representative examples include pancreatitis and pancreatic insufficiency.


Adverse Event Associated with Blood and Bone Marrow


Elevated Blood Pressure Measurement

An abnormally high blood pressure reading.


Grade 2 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intraoperative Ocular Injury, CTCAE

A finding of damage to the eye during a surgical procedure.


Grade 2 Neck Edema, CTCAE

Moderate neck edema; slight obliteration of anatomic landmarks; limiting instrumental ADL


Sporadic Gastric Diffuse Adenocarcinoma

A sporadic adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of poorly cohesive malignant cells and absence of glandular formations.


Cesarean Scar Pregnancy

An ectopic pregnancy implanted in a previous cesarean (hysterotomy) scar, surrounded by myometrium and connective tissue.


Urinary Tract Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Hypoparathyroidism, CTCAE

A disorder characterized by a decrease in production of parathyroid hormone by the parathyroid glands.


Leukoencephalopathy Radiographic Findings, CTCAE


Grade 3 Localized Edema, CTCAE

Severe localized edema and intervention indicated; limiting self care ADL


Grade 2 Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Colon Stricture or Stenosis, CTCAE


Kir6.2-Associated Diabetes Mellitus

Diabetes mellitus caused by activating mutation(s) in the KCNJ11 gene, encoding the inwardly rectifying Kir6.2 subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the KCNJ11 gene result in hyperinsulinism.


Grade 4 Prolapse of Intestinal Stoma, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Congenital neuropathy

Neuropathy, the cause of which is present at birth.


Grade 5 Anal Necrosis, CTCAE

Death


Grade 5 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Recurrent Ureter Carcinoma

The reemergence of ureter carcinoma after a period of remission


Cystitis Cystica and Glandularis

A reactive inflammatory disorder affecting the bladder.  It is characterized by the development of small cysts in the bladder wall.  The cysts are lined by urothelial cells and metaplastic glandular cells.


Vestibular Disorder, CTCAE

A disorder characterized by dizziness, imbalance, nausea, and vision problems.


Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Grade 3 Hypopituitarism, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Extrapyramidal Disorder, CTCAE

Mild involuntary movements


Non-Neoplastic Gallbladder Disorder

A non-neoplastic disorder that affects the gallbladder. Representative examples include cholecystitis and adenomyomatosis.


Stage III Low Grade Adult Non-Hodgkin's Lymphoma


Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Malignant Peripheral Nerve Sheath Tumor with Mesenchymal Differentiation

A malignant peripheral nerve sheath tumor characterized by the presence of mesenchymal differentiation.  Representative example is the malignant Triton tumor which contains a rhabdomyosarcomatous component.


Grade 4 Psychosis, CTCAE

Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Laceration

A cut or tear in any tissue.


Grade 2 Thrombosis or Embolism Vascular Access Related, CTCAE


Grade 2 Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Kidney Intra-Operative Injury, CTCAE


Grade 5 Thromboembolic Event, CTCAE

Death


Bisphosphonate-associated osteonecrosis

Necrosis of the mandible or maxilla in patients receiving intravenous or oral bisphosphonate therapy.  It usually manifests with slow healing or failure to heal of a jaw bone following oral surgery.  In a minority of cases, the necrosis appears spontaneously.  Signs and symptoms include pain, swelling and infection of the affected area.


Benign Extragonadal Germ Cell Tumor

A non-metastasizing germ cell tumor that arises from an anatomic site other than the testis or ovary.


Unspecified nonpsychotic mental disorder following organic brain damage

Any mental disorder that occurs secondary to organic brain damage, and that is not associated with psychosis.


Neutrophil Count Decreased, CTCAE

A finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen.


Grade 3 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Refractory Endometrial Squamous Cell Carcinoma

Endometrial transitional cell carcinoma that is resistant to treatment.


Gastrointestinal Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the gastrointestinal region.


Grade 1 Thromboembolic Event, CTCAE

Medical intervention not indicated (e.g., superficial thrombosis)


Kidney Mixed Epithelial and Stromal Tumor Family

A family of tumors ranging from predominantly cystic tumors (adult cystic nephromas) to tumors that are variably solid (mixed epithelial and stromal tumors) and contain biphasic epithelial and stromal components with spindle stroma, glands, and cysts. Most of these tumors are benign. (WHO 2016).


Fecal Incontinence, CTCAE

A disorder characterized by inability to control the escape of stool from the rectum.


A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the skin.


Refractory Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma that is resistant to treatment.


Nodular Sclerosis Classic Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for nodular sclerosis classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Grade 3 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Leukoencephalopathy, CTCAE

Asymptomatic; small focal T2/FLAIR hyperintensities; involving periventricular white matter or <1/3 of susceptible areas of cerebrum +/- mild increase in subarachnoid space (SAS) and/or mild ventriculomegaly


Cervical Meningocele

A congenital abnormality in the cervical region of the spine in which the meninges protrude through a defect in the spinal column.


Dyspnea, CTCAE

A disorder characterized by an uncomfortable sensation of difficulty breathing.


Acute Myeloid Leukemia with t(11;17)(q23;q21)

Acute myeloid leukemia with the variant RARA t(11;17)(q23;q21) and the expression of PLZF-RARA fusion protein.  It lacks differentiation response to retinoids treatment.


Grade 5 Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Pressure Chest Pain

The sensation of chest pain described as an object creating physical force.


Advanced cancer

A malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Upper Aerodigestive Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Glomerular Filtration Rate, CTCAE


Grade 4 Penis Intra-Operative Injury, CTCAE


Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Palmar-Plantar Erythrodysesthesia Syndrome, CTCAE

Minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain


Grade 4 Hemolytic Uremic Syndrome, CTCAE

Life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure)


Grade 3 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Pancreas Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 3 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Extrapyramidal Disorder, CTCAE

Death


Grade 3 Chills, CTCAE

Severe or prolonged, not responsive to narcotics


Grade 3 Hypohidrosis, CTCAE

Increase in body temperature; limiting self care ADL


Adult Nodular Sclerosis Classical Hodgkin Lymphoma

Nodular sclerosis classic Hodgkin lymphoma occurring in adults.


Chronic Myelomonocytic Leukemia-0

A chronic myelomonocytic leukemia characterized by the presence of less than 5 percent blasts in the bone marrow and less than 2 percent blasts in the peripheral blood.


Diffuse malignant lymphoma - large non-cleaved cell

Antiquated term for diffuse non-Hodgkin lymphomas composed of non-cleaved cells.  The vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large B-cell lymphomas).


Trichoblastic carcinoma

A rare biphasic malignant neoplasm with dual differentiation towards the specialized follicular stroma and germinative follicular cells, which can be strikingly atypical. (WHO 2018)


Grade 4 Hyponatremia, CTCAE

<120 mmol/L; life-threatening consequences


Shooting Pain

An intense sensation of discomfort or distress that radiates from one location to another sharply.


Stage IB Pancreatic Cancer AJCC v6 and v7

Stage IB includes: T2, N0, M0. T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 4 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


Pre-Malignant Skin Epithelial Lesion

A term that refers to precancerous epithelial pathologic processes that affect the skin.


Reactive lymphoid hyperplasia of lacrimal gland

A polyclonal proliferation of lymphoid tissue in the lacrimal gland. It usually presents as painless palpable masses leading to globe displacement, decreased motility, diplopia, and ptosis. It has a tendency to involve bilateral lacrimal glands. There is a higher incidence in females and in the setting of autoimmune disease. (WHO 2018)


Uterine Obstruction, CTCAE

A disorder characterized by blockage of the uterine outlet.


Grade 5 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Kidney Infection, CTCAE

A disorder characterized by an infectious process involving the kidney.


Sign or Symptom

Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom).


Paraphrenia

A form of schizophrenia characterized by delusions (of persecution or grandeur or jealousy); symptoms may include anger and anxiety and aloofness and doubts about gender identity; unlike other types of schizophrenia the patients are usually presentable and (if delusions are not acted on) may function in an apparently normal manner.


Grade 4 Generalized Edema, CTCAE

Life-threatening consequences


Asymptomatic human immunodeficiency virus infection

An infection caused by human immunodeficiency virus (HIV) that is asymptomatic at the time of testing.


Grade 5 Vas Deferens Anastomotic Leak, CTCAE

Death


21-hydroxylase deficiency - simple virilizing

A classic form of congenital adrenal hyperplasia that is characterized by severe 21-hydroxylase deficiency, resulting in glucocorticoid and mineralocorticoid deficiency, but without clinically significant salt wasting, and with androgen excess, which causes virilization in female infants.


Pharyngolaryngeal Pain, CTCAE

A disorder characterized by a sensation of marked discomfort in the pharyngolaryngeal region.


PERSISTENT MULLERIAN DUCT SYNDROME, TYPE I

Persistent Mullerian duct syndrome due to deficiency of anti-Mullerian hormone.


Grade 1 Hair Texture Abnormal, CTCAE

Present


Recurrent Cervical Adenocarcinoma

The reemergence of cervical adenocarcinoma after a period of remission.


Grade 1 Ileal Fistula, CTCAE

Asymptomatic


Grade 4 Chylothorax, CTCAE

Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Cranial Nerve IV Intra-Operative Injury, CTCAE


Non-Invasive Pancreatic Mucinous-Cystic Neoplasm

A cystic epithelial neoplasm characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and the absence of an invasive carcinomatous component.


Refractory Malignant Lymphoid Neoplasm

A malignant lymphoid neoplasm that does not respond to treatment.


Grade 3 Spermatic Cord Perforation, CTCAE


Hepatitis Viral, CTCAE

A disorder characterized by a viral pathologic process involving the liver parenchyma.


Splenic thrombosis

Formation of a blood clot (thrombus) in the lumen of the splenic vein or splenic artery.


Grade 5 Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage I Osteosarcoma AJCC v7

Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Combined BAP1-Inactivated Nevus

A combined nevus with a spitzoid component and inactivation of BAP1.


Acne aggravated

A flare of acne which may be precipitated by variety of factors, including hormonal activity, stress, oils and oily cosmetics, sweat, overwashing, and certain foods and drugs.


Grade 4 Pancreatic Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Malignant glioma of brain

A grade 3 or 4 glioma that arises from the brain. This category includes anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligoastrocytoma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma (all grade 3 gliomas), and glioblastoma (grade 4 glioma).


Injection Site Reaction or Extravasation Changes, CTCAE


Grade 2 Other Growth and Development, CTCAE


Grade 2 Otitis Externa, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 5 Pancreas Exocrine Enzyme Deficiency, CTCAE


Grade 5 Pharyngeal Hemorrhage, CTCAE

Death


Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Adenocarcinoma in situ in adenomatous polyp

A non-invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp.


Pseudoepitheliomatous hyperplasia

A benign lesion characterized by epidermal and adnexal epithelial hyperplasia.  It is caused by chronic inflammation and infection.  It may be associated with cutaneous neoplasms as well.


Cervical Squamous Intraepithelial Neoplasia 1

Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper two-thirds of the squamous epithelium and mild nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal third of the epithelium.


Grade 5 Ileal Hemorrhage, CTCAE

Death


Grade 2 Jugular Vein Intra-Operative Injury, CTCAE


Grade 1 Paroxysmal Atrial Tachycardia, CTCAE

Asymptomatic, intervention not indicated


Cerebral Hemangioblastoma

A hemangioblastoma that arises from the cerebrum. It  may be associated with von Hippel-Lindau disease.


Hodgkin's disease lymphocyte predominance type stage IV

Stage IV adult Hodgkin disease means there is disseminated (multifocal) involvement of one or more extralymphatic organs, with or without associated lymph node involvement, or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)


Recurrent Intracranial Neoplasm

The reemergence of an intracranial neoplasm after a period of remission.


Stage IIIB Cervical Cancer FIGO 2009

Cervical carcinoma involving the pelvic sidewall. (FIGO 2009)


Non-Neoplastic Eye Disorder

A non-neoplastic disorder that affects the eye.


Biliary Tract Infection, CTCAE

A disorder characterized by an infectious process involving the biliary tract.


Grade 5 Urostomy Stenosis, CTCAE

Death


Esophageal adenocarcinoma that has metastasized to a limited number of sites.


Grade 1 Ileal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 4 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Blood and lymphatic system disorders

Any deviation from the normal structure or function of the blood or lymphatic system that is manifested by a characteristic set of symptoms and signs.


Rectal Fissure, CTCAE

A disorder characterized by a tear in the lining of the rectum.


Metastatic Cervical Carcinoma

A carcinoma of the cervix that has spread to another anatomic site.


Grade 4 Pharyngitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Symptom

Subjective evidence of disease perceived by the patient.


Metastatic Infiltrating Bladder Urothelial Carcinoma, Lipid-Rich Variant

Bladder lipid-rich variant urothelial carcinoma that has spread to another anatomical site.


Hodgkin's disease nodular sclerosis stage II supradiaphragmatic


Grade 4 Biliary Tree Common Bile Duct Intra-Operative Injury, CTCAE


46,XX/46,XY Ovotesticular Differences of Sex Development

Ovotesticular differences of sex development in individuals with 46,XY/46,XX mosaic karyotype.


Elevated Test Result

A result of a test that is higher than a previous value or a normal range of values.


Grade 2 Intra-Abdominal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 1 Breast Nipple and Areolar Deformity, CTCAE


Grade 4 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Purpura, CTCAE

Combined area of lesions covering <10% BSA


Grade 3 Prolapse of Gastrointestinal Stoma, CTCAE


Grade 2 Hypercalcemia, CTCAE

Corrected serum calcium of >11.5-12.5 mg/dL; >2.9-3.1 mmol/L; Ionized calcium >1.5-1.6 mmol/L; symptomatic


Grade 4 Soft Tissue NOS Intra-Operative Injury, CTCAE


Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Nail Loss, CTCAE

Asymptomatic separation of the nail bed from the nail plate or nail loss


Low Grade Esophageal Glandular Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal glandular epithelium.


Oral Cavity Fistula, CTCAE

A disorder characterized by an abnormal communication between the oral cavity and another organ or anatomic site.


Grade 1 Heart Intra-Operative Injury, CTCAE


Grade 2 Pain, CTCAE

Moderate pain; limiting instrumental ADL


Cryptococcal gastroenteritis

Gastroenteritis resulting from an infection with cryptosporidium.


Grade 3 Neuroendocrine Gonadotropin Secretion Abnormality, CTCAE


Grade 3 Skin Induration, CTCAE

Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL


Grade 4 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Dysphasia, CTCAE

Awareness of receptive or expressive characteristics; not impairing ability to communicate


Unresectable Gastric Carcinoma

A gastric carcinoma that is not amenable to surgical resection.


Grade 2 Insomnia, CTCAE

Moderate difficulty falling asleep, staying asleep or waking up early


Grade 2 Blood Gonadotrophin Abnormal, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Soft Tissue Infection, CTCAE

A disorder characterized by an infectious process involving soft tissues.


Grade 5 Other Metabolic and Laboratory, CTCAE


Grade 1 Thrush, CTCAE

Asymptomatic; local symptomatic management


Grade 2 Scrotum Intra-Operative Injury, CTCAE


Grade 3 Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


Recurrent Fallopian Tube Endometrioid Adenocarcinoma

The reemergence of fallopian tube endometrioid adenocarcinoma after a period of remission.


Grade 4 Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


Gnathoschisis

A congenital abnormality consisting of clefting in the jaw, which results from incomplete fusion of the embryonic mandibular prominence.


Intraoperative Breast Injury

Damage to the breast parenchyma during a surgical procedure.


Non-Neoplastic Bone Disorder

A non-neoplastic disorder that affects the bone or articular cartilage.


Grade 4 Cervix Intra-Operative Injury, CTCAE


Grade 3 Skin Ulceration, CTCAE

Combined area of ulcers >2 cm; full-thickness skin loss involving damage to or necrosis of subcutaneous tissue that may extend down to fascia


Blood Prolactin Abnormal, CTCAE

A finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen.


Preexisting Genetic Condition

A condition that existed previously and is genetic in nature.


Grade 3 Pharyngeal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Nonerosive Arthritis

An inflammation of one or more joints, without loss of articular cartilage or destruction of subchondral bone.


Grade 3 Rectum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Complete Atrioventricular Septal Defect with Tetralogy of Fallot

A rare congenital heart anomaly in which there is coexistence of tetralogy of Fallot and complete atrioventricular septal defect. The latter is characterized by defects in the atrial and ventricular septa and a common atrioventricular valve.


Grade 5 Pharyngitis, CTCAE

Death


Gallbladder Adenocarcinoma, Biliary Type

A well or moderately differentiated adenocarcinoma that arises from the gallbladder.  It is the most common type of gallbladder carcinoma and is characterized by the presence of malignant tubular glands.  Intestinal differentiation may be present.


Grade 4 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Acidosis, CTCAE

Death


Locally Advanced Unresectable Sarcoma

A sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Fat Atrophy, CTCAE

A disorder characterized by shrinking of adipose tissue.


Recurrent Low Grade Glioma

The reemergence of low grade glioma after a period of remission.


Grade 2 Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Non-Neoplastic Endocrine Pancreas Disorder

A non-neoplastic disorder that affects the endocrine pancreas.


Estrogen Receptor Status 1+

An immunohistochemical result of 1 for estrogen receptor expression that is considered weak for expression.


Hepatic Infection, CTCAE

A disorder characterized by an infectious process involving the liver.


Grade 1 Sinus Tachycardia, CTCAE

Asymptomatic, intervention not indicated


Chest Pain in Intercostal Space

The location of the chest pain is in the area defined by a superior rib margin and an inferior rib margin.


Chronic Lymphoblastic Lymphoma

This is an invalid term; lymphoblastic lymphomas are not chronic processes, but counterparts of acute lymphoblastic leukemias.


Pneumonitis, CTCAE

A disorder characterized by inflammation focally or diffusely affecting the lung parenchyma.


Grade 3 Abdomen Soft Tissue Necrosis, CTCAE


Lip Infection

An acute or chronic infectious process affecting the lips.


Grade 5 Skin Ulceration, CTCAE

Death


Brain Development Abnormality

A group of congenital or acquired disorders that affect the normal development of the brain.


Grade 2 Lipase Increased, CTCAE

>1.5-2.0 x ULN; >2.0-5.0 x ULN and asymptomatic


Allergic arthritis

Arthritis occurring after the ingestion of allergenic substance(s).


Congenital deformity of hip joint

Any anatomic abnormality of the hip that is present at the time of birth.


Grade 2 Bronchopulmonary Hemorrhage NOS, CTCAE


Severe Gastrointestinal Tract Acute Graft Versus Host Disease

Graft versus host disease occurring in the gastrointestinal tract and is characterized by complications that may be life-threatening.


Grade 1 Fallopian Tube Stricture or Stenosis, CTCAE


Pathologic Stage I Retinoblastoma AJCC v8

Stage I includes: pT1, pT2, pT3, pN0, cM0, Any H. pT1: Intraocular tumor(s) without any local invasion, focal choroidal invasion, or pre-or intralaminar involvement of the optic nerve head. pT2: Intraocular tumor(s) with local invasion. pT3: Intraocular tumor(s) with significant local invasion. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Grade 2 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Lacrimal Drainage System Non-Keratinizing Squamous Cell Carcinoma

A squamous cell carcinoma of the lacrimal drainage system characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.


Grade 2 Vaginitis Not Due to Infection, CTCAE


Breast Atrophy, CTCAE

A disorder characterized by underdevelopment of the breast.


Refractory Urinary System Carcinoma

Urinary system carcinoma that does not respond to treatment.


Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Recurrent Malignant Male Reproductive System Neoplasm

Reemergence of a malignant male reproductive system neoplasm after a period of remission.


Enterovesical Fistula, CTCAE

A disorder characterized by an abnormal communication between the urinary bladder and the intestine.


Grade 3 Induration or Fibrosis of the Skin and Subcutaneous Tissue, CTCAE


Lipohypertrophy, CTCAE

A disorder characterized by hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin.


Infiltrating Bladder Urothelial Carcinoma with Squamous Differentiation

An invasive transitional cell carcinoma of the bladder that exhibits squamous differentiation.


Grade 2 Superficial Thrombophlebitis, CTCAE

Present


Grade 2 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Thyroid colloid nodule

A non-cancerous thyroid gland nodule that contains colloid material.


Grade 3 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Agitation, CTCAE 5.0

A disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension.


Clinical Stage I Retinoblastoma AJCC v8

Stage I includes: cT1, cT2, cT3, cN0, cM0, Any H. cT1: Intraretinal tumor(s) with subretinal fluid 5 mm or less from the base of any tumor. cT2: Intraocular tumor(s) with retinal detachment, vitreous seeding, or subretinal seeding. cT3: Advanced intraocular tumor(s). cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Papillary serous cystadenoma

A serous benign or low malignant potential cystic epithelial neoplasm characterized by the presence of glandular epithelial cells forming papillary structures.


Steroid Resistant Acute Graft Versus Host Disease

Acute graft versus host disease that is resistant to treatment with steroids.


Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Fallopian Tube Metaplastic Papillary Tumor

A rare metaplastic lesion that arises from the fallopian tube. It is characterized by the presence of an intraluminal papillary proliferation composed of atypical epithelial cells with abundant eosinophilic cytoplasm. In the vast majority of cases, it is an incidental finding during microscopic examination of a fallopian tube in the postpartum period.


Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE