Stage I Colorectal Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIB Colon Neuroendocrine Tumor AJCC v8

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Stage IIB includes: T3, N0, M0. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIB Rectal Neuroendocrine Tumor AJCC v8


Stage IIIB Colon Neuroendocrine Tumor AJCC v8

Stage IIIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIB Rectal Neuroendocrine Tumor AJCC v8


Rectal Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a rectal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to rectal "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the rectum are not staged using this staging system. (from AJCC 8th Ed.)


Stage IIB Colorectal Neuroendocrine Tumor AJCC v8


Stage IIA Colorectal Neuroendocrine Tumor AJCC v8

Stage IIA includes: T2, N0, M0. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIA Rectal Neuroendocrine Tumor AJCC v8


Colon Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of a colon neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to colon "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the colon are not staged using this staging system. (from AJCC 8th Ed.)


Stage IIIB Colorectal Neuroendocrine Tumor AJCC v8


Stage I Colon Neuroendocrine Tumor AJCC v8


Stage IIIA Colon Neuroendocrine Tumor AJCC v8

Stage IIIA includes: T4, N0, M0. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIA Colon Neuroendocrine Tumor AJCC v8


Stage IIIA Colorectal Neuroendocrine Tumor AJCC v8


Grade 1 Cardiac Disorders - Other, Specify, CTCAE

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Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Cardiac Disorders - Other, Specify, CTCAE


Grade 2 Cardiac Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 5 Cardiac Disorders - Other, Specify, CTCAE

Death


Grade 3 Cardiac Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 4 Cardiac Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Phosphaturic mesenchymal tumor, malignant

A phosphaturic mesenchymal tumor characterized by the presence of nuclear atypia, high mitotic activity, increased cellularity, marked pleomorphism, and necrosis. It usually develops in lesions that have recurred locally and metastasizes to other sites.


Metastatic malignant neoplasm to trachea

A malignant neoplasm that has spread to the trachea from another anatomic site.


Grade 1 Ejaculation Disorder, CTCAE

Diminished ejaculation


Ejaculation Disorder, CTCAE

A disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation.


Grade 2 Ejaculation Disorder, CTCAE

Anejaculation or retrograde ejaculation


Grade 4 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Bilateral Synchronous Sporadic Renal Cell Carcinoma

Non-hereditary renal cell carcinoma arising from a kidney and detected in the other kidney within six months of the first primary. The majority are clear cell renal cell carcinomas.


Kidney Germ Cell Tumor

A rare benign or malignant germ cell tumor that arises from the kidney.


Grade 3 Sinus Pain, CTCAE

Severe pain; limiting self care ADL


paraben

A 4-hydroxybenzoate ester in which the esterifying alcohol is an alkanol (in diagram, R = alkyl). Commonly used as preservatives in cosmetic and pharmaceutical products.


Arteriovenous graft thrombosis

Partial or complete occlusion of the lumen of an arteriovenous graft by a thrombus.


Grade 5 Epistaxis, CTCAE

Death


Grade 3 Trismus, CTCAE

Decreased ROM with inability to adequately aliment or hydrate orally


Refractory Childhood Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia that occurs in childhood and does not respond to treatment.


Childhood Acute Basophilic Leukemia

An acute basophilic leukemia occurring in children.


Sinonasal Solitary Fibrous Tumor

A solitary fibrous tumor that arises from the nasal cavity and paranasal sinuses.


Supernumerary Hemivertebra

More than the usual or expected number of hemivertebra.


Malignant neoplasm of hypopharynx recurrent

The reemergence of a hypopharyngeal malignant neoplasm after a period of remission.


Benign neoplasm of pyriform sinus

A non-metastasizing neoplasm that arises from the pyriform sinus.


Neoplasm of pyriform sinus

A benign or malignant neoplasm that affects the pyriform sinus.


COVID-19-Associated Anosmia

Anosmia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Grade 3 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Tentorial tear due to birth trauma

Pertaining to tears involving the tentorium of the cerebellum.


Grade 4 Stoma Pulmonary Hemorrhage, CTCAE


Resectable Carcinoma

Carcinoma that is amenable to surgical resection.


Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that is amenable to surgical resection.


Carcinoma duodenum resectable

Carcinoma of the duodenum amendable to surgical removal.


Resectable Periampullary Adenocarcinoma

Periampullary adenocarcinoma that is amenable to surgical removal.


Resectable Liver and Intrahepatic Bile Duct Carcinoma

Liver and intrahepatic bile duct carcinoma that is amenable to surgical resection.


Resectable Digestive System Carcinoma

Digestive system carcinoma that is amenable to surgical resection.


Resectable Skin Squamous Cell Carcinoma

Skin squamous cell carcinoma that is amenable to surgical resection.


Localized Resectable Adult Liver Carcinoma

A localized hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and it is amenable to surgical resection.


Resectable Head and Neck Squamous Cell Carcinoma

Squamous cell carcinoma of the head and neck which is amendable to surgical removal.


Resectable Skin Carcinoma

Skin carcinoma that is amenable to surgical resection.


Small intestine carcinoma resectable

Carcinoma of the small intestine amendable to resection.


Resectable Colon Carcinoma

Colon carcinoma that is amenable to surgical resection.


Localized Resectable Adult Hepatocellular Carcinoma

A localized hepatocellular carcinoma that occurs during adulthood and it is amenable to surgical resection.


Resectable Colorectal Carcinoma

Colorectal carcinoma that is amenable to surgical resection.


Carcinoma liver resectable

A hepatocellular carcinoma that is amenable to surgical resection.


Resectable Bladder Urothelial Carcinoma

Bladder urothelial carcinoma that is amenable to surgical resection.


Gastric Xanthoma

A xanthoma located in the stomach.


Grade 1 Scalp Pain, CTCAE

Mild pain


Childhood Cerebellar Anaplastic Astrocytoma

A cerebellar anaplastic astrocytoma that occurs during childhood.


Recurrent Childhood Cerebellar Astrocytoma

Regrowth of benign and malignant childhood cerebellar astrocytomas that have previously been subjected to surgical resection and less frequently other forms of therapy such as radiation or chemotherapy.  Recurrence of benign tumors (e.g., (pilocytic astrocytoma) may respond to a second surgical procedure.


Grade 2 Oral Cavity Pulmonary Fistula, CTCAE


Stage II Lip Cancer AJCC v6 and v7

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Lower Gingival Verrucous Carcinoma

A verrucous carcinoma of the oral cavity that arises from the lower gingiva.


Verrucous carcinoma of the oral cavity recurrent

Reemergence of verrucous carcinoma of the oral cavity after a period of remission.


Buccal Mucosa Verrucous Carcinoma

A verrucous carcinoma of the oral cavity that arises from the buccal mucosa.


Oral Cavity Carcinoma Cuniculatum

A variant of well-differentiated squamous cell carcinoma arising from the oral cavity. It is characterized by the presence of minimal cytological atypia, multiple keratin-filled crypts, and intraepithelial neutrophils.


Upper Gingival Verrucous Carcinoma

A verrucous carcinoma of the oral cavity that arises from the upper gingiva.


Positive Laboratory Test Result

A laboratory test result that indicates that a specific disease, condition, or attribute being assessed is present.


Human Immunodeficiency Virus 1 Positive

Indicates that human immunodeficiency virus 1 has been detected in a sample.


Progesterone Receptor Positive by Immunohistochemistry

An immunohistochemical staining finding indicating that cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 1-9 Percent

An immunohistochemical staining finding indicating that between 1 and 9 percent of the cells in a tissue sample are expressing progesterone receptor.


Disseminated Tumor Cells Positive

An indication that single tumor cells or small clusters of tumor cells have been detected in a tissue sample.


Progesterone Receptor Positive by Immunohistochemistry 81-90 Percent

An immunohistochemical staining finding indicating that 81-90 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Status 3+

An immunohistochemical result of 3 for progesterone receptor expression that is considered positive for expression.


Monoclonal Band

Monoclonal immunoglobulin or monoclonal light chain that is present in the serum and/or urine. It is the result of a clonal B-cell or plasma cell proliferation.


Hormone Receptor Positive

A finding indicating that the neoplastic cells in a tissue sample test positive for estrogen and/or progesterone receptors.


Progesterone Receptor Positive by Immunohistochemistry 51-60 Percent

An immunohistochemical staining finding indicating that 51-60 percent of the cells in a tissue sample are expressing progesterone receptor.


Expression Positive

An indication that the expression of a gene, transcript or protein has been detected in a sample.


Progesterone Receptor Positive by Immunohistochemistry Less than 1 Percent

An immunohistochemical staining finding indicating that less than 1 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 91-100 Percent

An immunohistochemical staining finding indicating that 91-100 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 21-30 Percent

An immunohistochemical staining finding indicating that 21-30 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 71-80 Percent

An immunohistochemical staining finding indicating that 71-80 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 41-50 Percent

An immunohistochemical staining finding indicating that 41-50 percent of the cells in a tissue sample are expressing progesterone receptor.


Rearrangement Detected

An indication that a cytogenetic rearrangement was detected in a sample.


Progesterone Receptor Positive by Immunohistochemistry 31-40 Percent

An immunohistochemical staining finding indicating that 31-40 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 61-70 Percent

An immunohistochemical staining finding indicating that 61-70 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 1-10 Percent

An immunohistochemical staining finding indicating that 1-10 percent of the cells in a tissue sample are expressing progesterone receptor.


Progesterone Receptor Positive by Immunohistochemistry 11-20 Percent

An immunohistochemical staining finding indicating that 11-20 percent of the cells in a tissue sample are expressing progesterone receptor.


Refractory Hairy Cell Leukemia Variant

Hairy cell leukemia variant that is resistant to treatment.


HHV-8-Associated Multicentric Castleman Disease

A systemic form of angiofollicular hyperplasia associated with HHV8 infection.


Sellar Chondroid Chordoma

A chondroid chordoma that arises from the sellar region.


Conventional Chordoma

A malignant bone tumor arising from the remnants of the fetal notochord. It is characterized by the presence of large epithelioid cells with clear to light eosinophilic cytoplasm. Some of the cells are large with bubbly, vacuolated cytoplasm (physaliphorous cells). The cells form cords and nests that are embedded within an extracellular myxoid matrix.


Grade 1 Abducens Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


An adenocarcinoma that arises from the sinonasal tract. It is characterized by the absence of features that resemble intestinal adenocarcinoma.


Recurrent Malignant Mastocytosis

The reemergence of malignant mastocytosis after a period of remission.


Psychogenic Musculoskeletal Chest Pain with Dysfunctional Breathing

A condition in which there is musculoskeletal chest pain associated with inappropriate hyperpnea or tachypnea. (ACC/AHA)


Psychogenic Musculoskeletal Chest Pain

A condition in which there is the sensation of musculoskeletal chest pain due to a conversion disorder. (ACC/AHA)


Sellar Gangliocytoma

A tumor that arises in the sellar region and is characterized by the presence of mature ganglion cells and neuronal differentiation. It is often associated with the presence of pituitary neuroendocrine tumors/adenomas.


Double-Negative Prostate Carcinoma

A metastatic, castration-resistant prostate carcinoma that is composed of fibroblast growth factor-driven malignant cells.


Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents

Castration-resistant prostate carcinoma which is refractory to second-generation androgen receptor axis-targeted agents, namely abiraterone and enzalutamide.


Intermediate Atypical Prostate Carcinoma

An aggressive, castration-resistant, histologically distinct, metastatic carcinoma arising from the prostate gland. It is characterized by the presence of a pure population of cytologically bland malignant epithelial cells with moderate to abundant cytoplasm and rare mitotic figures. The prognosis is poor.


Aggressive Variant Prostate Carcinoma

A lethal form of advanced castration-resistant prostate carcinoma that emerges in the later stages of castration-resistant treatment. It is an adaptive response to androgen receptor pathway inhibition. The morphologic features vary, ranging from poorly differentiated carcinomas to mixed adenocarcinoma-small cell carcinomas to pure small cell carcinomas expressing neuroendocrine markers. Clinically, it manifests with rapidly progressive disease, visceral or lytic bone metastases and bulky tumor masses. Molecular studies have shown the loss of tumor suppressor genes TP53 and RB1.


Grade 4 Pericardial Effusion, CTCAE

Life-threatening consequences; urgent intervention indicated


Advanced Unfavorable Hodgkin Lymphoma

An advanced Hodgkin lymphoma with unfavorable prognosis.


allylamine antifungal drug

An organonitrogen compound that contains an amino group that is attached to a carbon which is itself attached to an olefinic carbon and which has been used as an antifungal drug.


Situs inversus thoracis

A congenital condition in which there is complete right-to-left reversal of the position of the thoracic organs.


Urethritis Glandularis

A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by metaplastic glandular cells.


magnesium oxide nanocrystal

A nanocrystal composed of magnesium oxide.


Dialysis Catheter Tunnel Infection

Local infection involving the subcutaneously tunneled portion of a dialysis catheter.


Grade 4 Stevens-Johnson Syndrome, CTCAE

Skin sloughing covering 10-30% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment)


Grade 4 Gastrointestinal Stoma Hemorrhage, CTCAE


Lugano Classification Stage IV Adult Hodgkin Lymphoma AJCC v8

Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the CSF, bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


Lugano Classification Stage IV Adult Lymphoma AJCC v8


Grade 2 Musculoskeletal Deformity, CTCAE

Deformity, hypoplasia, or asymmetry able to be remediated by prosthesis (e.g., shoe insert) or covered by clothing


Pelvic Infection, CTCAE

A disorder characterized by an infectious process involving the pelvic cavity.


Grade 3 Pelvic Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Pelvic Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 5 Pelvic Infection, CTCAE

Death


Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Grade 3 Middle Ear Intra-Operative Injury, CTCAE


Astrocytoma, Not Otherwise Specified

A central nervous system tumor with morphological features of astrocytoma in which there is insufficient information on the IDH genes status.


Grade 3 Superficial Soft Tissue Fibrosis, CTCAE

Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL


Grade 1 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Ciliary Body Benign Teratoid Medulloepithelioma

A rare, unilateral, benign embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium and contains heterologous elements, particularly cartilage, skeletal muscle, and brain tissue.


Recurrent Extragonadal Seminoma

The reemergence of extragonadal seminoma after a period of remission.


Recurrent Malignant Extragonadal Germ Cell Tumor

The reemergence of malignant extragonadal germ cell tumor after a period of remission.


Recurrent Malignant Extragonadal Nongerminomatous Germ Cell Tumor

The reemergence of a malignant extragonadal nongerminomatous germ cell tumor after a period of remission.


Stage IA Cervical Cancer FIGO 2018

Invasive cervical carcinoma that can be diagnosed only by microscopy, with maximum depth of invasion less than 5 mm. (FIGO 2018)


Stage IA2 Cervical Cancer FIGO 2018

Cervical carcinoma with measured stromal invasion equal or more than 3 mm and less than 5 mm in depth. (FIGO 2018)


Stage IA1 Cervical Cancer FIGO 2018

Cervical carcinoma with measured stromal invasion less than 3 mm in depth. (FIGO 2018)


Quinoxaline

A naphthyridine in which the nitrogens are at positions 1 and 4.


Grade 3 Vagina Stricture or Stenosis, CTCAE


Stage I Pancreatic Neuroendocrine Tumor AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor limited to the pancreas and measuring less than 2 cm. N0: No regional lymph node involvement. M0: No distant metastasis. (AJCC 8th ed.)


Infiltrating Intramuscular Lipoma

An infiltrating lipoma that affects skeletal muscle.  It has a higher rate of local recurrence.


Refractory Endometrial Dedifferentiated Carcinoma

Endometrial dedifferentiated carcinoma that is resistant to treatment.


Campylobacter jejuni infection

An infection that is caused by Campylobacter jejuni.


Small Intestinal Infection

An infectious process affecting the small intestine.


Duodenal Infection

An infectious process affecting the duodenum.


Stage IVB Rectal Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis.  (AJCC 8th ed.)


Cervical Mucinous Adenocarcinoma, Not Otherwise Specified

A cervical mucinous adenocarcinoma in which more than 50% of malignant cells contain intracytoplasmic mucin. There is no evidence of gastric, intestinal, or signet ring cell differentiation.


glycerolipid

Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.


triradylglycerol

A glycerol compound having one of three possible substituent groups - either acyl, alkyl, or alk-1-enyl - at each of the three possible positions sn-1, sn-2 or sn-3. has functional parent glycerol (CHEBI:17754), children: triglyceride (CHEBI:17855). Parent: is_a glycerolipid (CHEBI:35741)


glyceride

Any ester resulting from the condensation of one or more of the hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl substituents at positions 1 and 2 are specified as gamma-linolenoyl and oleoyl respectively.


An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.


glycerophospholipid

Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.


Triglyceride

Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


Hepatitis Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis virus exposure and injury of the liver parenchyma.


Stage IIIA Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage IIIA includes: T3a, N0, M0. T3a: Multiple tumors more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Epithelioid hemangioendothelioma of liver

A low-grade malignant blood vessel neoplasm that arises from the liver.  It is characterized by the presence of epithelioid endothelial cells.  The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma.  Patients may be asymptomatic or present with an abdominal mass, ascites, and jaundice.


Stage I Intrahepatic Bile Duct Cancer AJCC v8

Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0). T1a: Solitary tumor equal to or less than 5 cm without vascular invasion.  T1b: Solitary tumor larger than 5 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Unresectable Fibrolamellar Carcinoma

A fibrolamellar carcinoma that is not amenable to surgical resection.


Hepatoblastoma with Pure Fetal Epithelial Differentiation

A hepatoblastoma composed of small cells resembling the fetal hepatocytes, forming thin trabeculae.


Recurrent Adult Hepatocellular Carcinoma

A hepatocellular carcinoma that occurs during adulthood and has recurred after a period of remission.


Locally Advanced Hepatocellular Carcinoma

Hepatocellular carcinoma that has spread to nearby tissues or lymph nodes.


Hepatoblastoma recurrent

The reemergence of hepatoblastoma after a period of remission.


Stage IV Childhood Hepatocellular Carcinoma AJCC v7

Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


BCLC Stage 0 Hepatocellular Carcinoma

Very early hepatocellular carcinoma. Patients are optimal candidates for resection. (HPB (Oxford) 2005; 7(1):35-41)


BCLC Stage D Hepatocellular Carcinoma

End-stage hepatocellular carcinoma.  Patients will receive symptomatic treatment. (HPB (Oxford) 2005; 7(1):35-41)


Adult Liver Carcinoma

A hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood.


Stage IV Liver Cancer

Stage IV carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Metastatic Fibrolamellar Carcinoma

A fibrolamellar carcinoma that has spread from the liver to another anatomic site.


Stage III Hepatocellular Carcinoma AJCC v7

Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVA Hepatocellular Carcinoma AJCC v7

Stage IVA includes: Any T, N1, M0.  N1: Regional lymph node metastasis. M0: No distant metastasis.  (AJCC 7th ed.)


PRETEXT Stage 4 Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves all 4 quadrants; there is no quadrant free of tumor. (from PDQ 2004)


Non-Resectable Malignant Liver Neoplasm

A malignant neoplasm that affects the liver and it is not amenable to surgical resection.


Adult Pleomorphic Hepatocellular Carcinoma

A pleomorphic hepatocellular carcinoma that occurs during adulthood.


Stage IV Hepatocellular Carcinoma AJCC v7


BCLC Stage C Adult Hepatocellular Carcinoma

Advanced hepatocellular carcinoma.  Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41)


Stage IV Hepatocellular Carcinoma AJCC v6

Stage IV includes (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.)


Extrarenal Rhabdoid Tumor of the Liver

A rare, aggressive primary malignant tumor of the liver that occurs in childhood.  It is characterized by the presence of a diffuse infiltrate of undifferentiated cells with rhabdoid features.


Stage II Liver Cancer

Stage II carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Postsurgical Stage III Hepatoblastoma

No distant metastases, tumor unresectable or resected with gross residual tumor, or positive lymph nodes. (from PDQ 2004)


PRETEXT Stage 3 Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 3 adjoining quadrants or 2 nonadjoining quadrants; 1 quadrant or 2 nonadjoining quadrants are free of tumor. (from PDQ 2004)


Refractory Hepatoblastoma

Hepatoblastoma that does not respond to treatment.


Uveal Melanoma Metastatic in the Liver

A melanoma that originates from melanocytes of the uveal tract and has spread to the liver.


Stage II Hepatocellular Carcinoma AJCC v8

Stage II includes: T2, N0, M0. T2: Solitary tumor larger than 2 cm with vascular invasion, or multiple tumors, none larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Liver Small Cell Neuroendocrine Carcinoma

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver. It is characterized by the presence of malignant small cells.


Stage IV Intrahepatic Bile Duct Cancer AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Stage IIIA Hepatocellular Carcinoma AJCC v7

Stage IIIA includes: T3a, N0, M0.  T3a: Multiple tumors more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Liver Cancer

Stage III carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Stage IIIC Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage IIIC includes: T4, N0, M0.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage I Hepatocellular Carcinoma AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Solitary tumor without vascular invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Colon Carcinoma Metastatic in the Liver

A carcinoma that originates from the colonic wall and has spread to the liver.


Stage III Hepatocellular Carcinoma AJCC v8

Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0). T3: Multiple tumors, at least one of which is larger than 5 cm. T4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIA Intrahepatic Bile Duct Cancer AJCC v8

Stage IIIA includes: T3, N0, M0. T3: Tumor perforating the visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Liver Mixed Adenoneuroendocrine Carcinoma

A carcinoma that arises from the liver and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Moderately Differentiated Hepatocellular Carcinoma

A hepatocellular carcinoma characterized by the presence of malignant cells with abundant eosinophilic cytoplasm forming trabecular and pseudoglandular patterns.  It is usually associated with tumors that are larger than 3 cm in diameter.


Hepatocellular carcinoma, spindle cell variant

A morphologic variant of hepatocellular carcinoma characterized by the presence of malignant spindle cells or atypical giant cells.


carcinosarcoma of liver

An aggressive carcinoma with a sarcomatous component that arises from the liver.  The sarcomatous component is clonally related to the more differentiated, carcinomatous component.  The prognosis is usually poor.


Hepatic cancer stage IVA

Stage IVA carcinoma of the liver according to the American Joint Committee on Cancer, 7th and 8th editions.


Stage II Intrahepatic Bile Duct Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Solitary tumor with intrahepatic vascular invasion, or multiple tumors, with or without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Hepatocellular Malignant Neoplasm, Not Otherwise Specified

A rare childhood malignant liver neoplasm with overlapping features of hepatoblastoma and hepatocellular carcinoma.


Stage I Childhood Hepatocellular Carcinoma AJCC v6 and v7


Locally Advanced Liver Carcinoma

Liver carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Teratoid Hepatoblastoma

A hepatoblastoma characterized by the presence of mixed epithelial and mesenchymal components and additional tissues such as striated muscle, bone, epithelial tissues, and melanin pigment.


BCLC Stage B Hepatocellular Carcinoma

Intermediate hepatocellular carcinoma.  Patients may benefit from chemoembolization. (HPB (Oxford) 2005; 7(1):35-41)


Kaposi's sarcoma of liver

A Kaposi sarcoma that arises from the liver.


Stage IA Intrahepatic Bile Duct Cancer AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Solitary tumor equal to or less than 5 cm without vascular invasion.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Hepatocellular carcinoma characterized by the presence of diffuse neutrophil infiltrates within the tumor.


Stage IIIB Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage IIIB includes: T3b, N0, M0. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage 0 Intrahepatic Bile Duct Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ (intraductal tumor). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic hepatocellular carcinoma

A hepatocellular carcinoma that has spread to another anatomic site.


Unresectable Liver and Intrahepatic Bile Duct Carcinoma

Liver and intrahepatic bile duct carcinoma that is not amenable to surgical resection.


Recurrent Childhood Hepatocellular Carcinoma

A hepatocellular carcinoma that occurs during childhood and has recurred after a period of remission.


Liver and Intrahepatic Bile Duct Malignant Non-Epithelial Neoplasm

A malignant non-epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts.  Representative examples include lymphoma, angiosarcoma, and undifferentiated (embryonal) sarcoma.


BCLC Stage B Adult Hepatocellular Carcinoma


Hepatocellular Carcinoma by AJCC v8 Stage

A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to hepatocellular carcinomas and fibrolamellar carcinomas (fibrolamellar variant of hepatocellular carcinoma). Intrahepatic cholangiocarcinomas, combined hepatocellular-cholangiocarcinomas, and sarcomas of the liver are not staged using this staging system. (from AJCC 8th Ed.)


A hepatocellular carcinoma that arises in a patient with a history of organ transplantation.


Hepatitis B Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis B virus exposure and injury of the liver parenchyma.


Hepatitis C Virus-Related Hepatocellular Carcinoma

A hepatocellular carcinoma that develops following hepatitis C virus exposure and injury of the liver parenchyma.


BCLC Stage 0 Adult Hepatocellular Carcinoma

Very early hepatocellular carcinoma. Patients are optimal candidates for resection. (HPB (Oxford) 2005; 7(1):35-41)


Localized Non-Resectable Adult Liver Carcinoma

A localized hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and it is not amenable to surgical resection.


Recurrent Childhood Liver Cancer

A hepatocellular carcinoma or hepatoblastoma that occurs during childhood and has recurred after a period of remission.


Liver Yolk Sac Tumor

A yolk sac tumor that arises from the liver.


Stage I Liver Carcinoma

Stage I carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Colorectal Adenocarcinoma Metastatic in the Liver

An adenocarcinoma that originates from the colorectal area and has spread to the liver.


Stage IV Hepatocellular Carcinoma AJCC v8

Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Postsurgical Stage IV Hepatoblastoma

Distant metastases, regardless of the extent of liver involvement. (from PDQ 2004)


Small Cell Undifferentiated Hepatoblastoma

A hepatoblastoma composed exclusively of noncohesive sheets of small undifferentiated cells.


Postsurgical Stage I Hepatoblastoma

No metastases, tumor completely resected. (from PDQ 2004)


Well Differentiated Hepatocellular Carcinoma

A hepatocellular carcinoma characterized by the presence of malignant cells with mild atypia and an increased nuclear/cytoplasmic ratio forming thin trabecular patterns.  It is usually associated with small tumors and an early stage.


Stage IB Intrahepatic Bile Duct Cancer AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Solitary tumor larger than 5 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IVA Hepatocellular Carcinoma AJCC v8

Stage IVA includes: Any T, N1, M0. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


BCLC Stage A Adult Hepatocellular Carcinoma

Early hepatocellular carcinoma.  Patients are candidates for radical therapies (resection, liver transplantation, or percutaneous treatments). (HPB (Oxford) 2005; 7(1):35-41)


Stage II Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage II includes: T2, N0, M0. T2: Solitary tumor with vascular invasion or multiple tumors none more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis.  For intrahepatic cholangiocarcinoma: Stage II includes: T2, N0, M0. T2: Solitary tumor with vascular invasion or multiple tumors, with or without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 7th Ed.)


Stage III Childhood Hepatocellular Carcinoma AJCC v7

Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Hepatoblastoma resectable

Hepatoblastoma amenable to surgical removal.


Stage IVB Hepatocellular Carcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Hepatocellular Carcinoma by AJCC v7 Stage

A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 7th edition.


Stage IIIB Hepatocellular Carcinoma AJCC v8

Stage IIIB includes: T4, N0, M0. T4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Localized Unresectable Adult Hepatocellular Carcinoma

A localized hepatocellular carcinoma that occurs during adulthood and it is not amenable to surgical resection.


Adult Fibrolamellar Carcinoma

A hepatocellular carcinoma, fibrolamellar variant that occurs during adulthood.


Poorly Differentiated Hepatocellular Carcinoma

A hepatocellular carcinoma characterized by the presence of malignant pleomorphic cells forming solid patterns.


Recurrent Fibrolamellar Carcinoma

The reemergence of fibrolamellar carcinoma after a period of remission.


undifferentiated carcinoma of liver

A rare carcinoma that arises from the liver.  The diagnosis is made by immunohistochemical studies.  Morphologic studies alone cannot establish the diagnosis of carcinoma or further subclassify the malignant tumor.


A hepatocellular carcinoma that develops following alcohol-induced injury of the liver parenchyma.


Stage IVB Hepatocellular Carcinoma AJCC v7

Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


BCLC Stage C Hepatocellular Carcinoma

Advanced hepatocellular carcinoma.  Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41)


Stage I Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage I includes: T1, N0, M0. T1: Solitary tumor without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis.  For intrahepatic cholangiocarcinoma: Stage I includes: T1, N0, M0. T1: Solitary tumor without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 7th Ed.)


Small Hepatocellular Carcinoma

Hepatocellular carcinoma measuring equal to or less than 2 cm in diameter. It includes early hepatocellular carcinoma and small progressed hepatocellular carcinoma.


Pleomorphic Hepatocellular Carcinoma

A morphologic variant of hepatocellular carcinoma, characterized by the presence of malignant cells which show marked variation in their size and shape. Bizarre mononuclear or multinucleated giant cells are often present.


Stage IIIB Hepatocellular Carcinoma AJCC v7

Stage IIIB includes: T3b, N0, M0. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein. T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis.  For intrahepatic cholangiocarcinoma: Stage III includes: T3, N0, M0. T3: Tumor perforating the visceral peritoneum or involving the local extra hepatic structures by direct invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 7th Ed.)


large cell neuroendocrine carcinoma of liver

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver. It is characterized by the presence of malignant large cells.


PRETEXT Stage 1 Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves only 1 quadrant; 3 adjoining liver quadrants are free of tumor. (from PDQ 2004)


Hepatocellular Carcinoma by AJCC v6 Stage

A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 6th edition.


Hepatocellular Carcinoma by BCLC Stage

A staging classification system for hepatocellular carcinoma that uses variables related to tumor stage, liver functional status, physical status, and cancer-related symptoms, and links the stages with a treatment algorithm. (HPB (Oxford) 2005; 7(1):35-41)


Hepatoblastoma non-resectable

Hepatoblastoma not amenable to surgical removal.


Intrahepatic Bile Duct Cancer by AJCC v8 Stage

A term that refers to the staging of intrahepatic bile duct cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to intrahepatic cholangiocarcinomas, combined hepatocellular-cholangiocarcinomas (mixed hepatocholangiocarcinomas), and primary neuroendocrine tumors of the liver. Primary sarcomas of the liver, pure hepatocellular carcinomas, hilar cholangiocarcinomas, and gallbladder carcinomas are not staged using this staging system. (from AJCC 8th Ed.)


Stage III Intrahepatic Bile Duct Cancer AJCC v8

Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0); (Any T, N1, M0). T3: Tumor perforating the visceral peritoneum. T4: Tumor involving local extrahepatic structures by direct invasion. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Chromophobe Hepatocellular Carcinoma

Hepatocellular carcinoma characterized by the presence of malignant cells with smooth chromophobic cytoplasm, abrupt focal nuclear anaplasia, and scattered microscopic pseudocysts.


Recurrent Hepatocellular Carcinoma

The reemergence of hepatocellular carcinoma after a period of remission


BCLC Stage A Hepatocellular Carcinoma

Early hepatocellular carcinoma.  Patients are candidates for radical therapies (resection, liver transplantation, or percutaneous treatments). (HPB (Oxford) 2005; 7(1):35-41)


Refractory Liver Carcinoma

Liver carcinoma that is resistant to treatment.


Stage IVB Liver Cancer

Stage IVB carcinoma of the liver according to the American Joint Committee on Cancer, 7th and 8th editions.


Refractory Hepatocellular Carcinoma

Hepatocellular carcinoma that is resistant to treatment.


Metastatic Carcinoma in the Liver

A carcinoma that has spread to the liver from another primary anatomic site.  Representative examples include metastatic carcinomas from the colon, breast, and lung.


Early Hepatocellular Carcinoma

A low grade, well differentiated small hepatocellular carcinoma. It lacks obvious stromal invasion and significant atypia.


Liver Plasmacytoma

A plasmacytoma that arises in the liver.


Stage II Hepatocellular Carcinoma AJCC v6 and v7

Stage II includes: T2, N0, M0.  T2: Solitary tumor with vascular invasion or multiple tumors none more than 5 cm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


A rare type of hepatocellular carcinoma characterized by the presence of pleomorphic malignant cells that are intermixed with lymphocytes.


Stage III Hepatocellular Carcinoma AJCC v6

Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0); IIIC: (Any T, Any N, M0).  IIIA: T3: Multiple tumors more than 5 cm or tumor involving a major branch of the portal or hepatic vein(s).  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


PRETEXT Stage 2 Hepatoblastoma

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 2 adjoining quadrants; 2 adjoining quadrants are free of tumor. (from PDQ 2004)


Stage IV Adult Liver Cancer AJCC v7

For hepatocellular carcinoma: Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis.  For intrahepatic cholangiocarcinoma: Stage IVA includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor with periductal invasion. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis.  Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 7th Ed.)


Unresectable Hepatocellular Carcinoma

A hepatocellular carcinoma that is not amenable to surgical resection.


Hepatoblastoma with Combined Fetal and Embryonal Epithelial Differentiation

A hepatoblastoma composed of cells resembling fetal epithelial cells and small round cells resembling blastema cells.


Rectal Carcinoma Metastatic in the Liver

A carcinoma that originates from the rectum and has spread to the liver.


Adult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

A combined hepatocellular carcinoma and cholangiocarcinoma that occurs during adulthood.


Stage IIIA Hepatocellular Carcinoma AJCC v8

Stage IIIA includes: T3, N0, M0. T3: Multiple tumors, at least one of which is larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIC Hepatocellular Carcinoma AJCC v7

Stage IIIC includes: T4, N0, M0.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Childhood Malignant Liver Neoplasm

A malignant neoplasm of the liver developed in childhood.  Representative examples include hepatoblastoma, undifferentiated (embryonal) sarcoma, and extrarenal rhabdoid tumor.


BCLC Stage D Adult Hepatocellular Carcinoma

End-stage hepatocellular carcinoma.  Patients will receive symptomatic treatment. (HPB (Oxford) 2005; 7(1):35-41)


Macrotrabecular Massive Hepatocellular Carcinoma

Hepatocellular carcinoma characterized by more than 50% growth of macrotrabecular pattern (equal to or more than 6 to 10 cells thick). It presents with higher grade and stage compared to conventional hepatocellular carcinoma. It has poor prognosis with early recurrence and poor overall survival.


Stage II Childhood Hepatocellular Carcinoma AJCC v6 and v7


Stage IIIB Intrahepatic Bile Duct Cancer AJCC v8

Stage IIIB includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor involving local extrahepatic structures by direct invasion. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Hepatocellular carcinoma characterized by the presence of steatohepatitis features, including macrovesicular steatosis, fibrosis, ballooning of malignant hepatocytes, Mallory bodies, and inflammation.


Colorectal Carcinoma Metastatic in the Liver

A carcinoma that originates from the colorectal area and has spread to the liver.


Small Progressed Hepatocellular Carcinoma

A well to moderately differentiated small hepatocellular carcinoma. It is characterized by the presence of obvious stromal invasion and increase atypia compared with early hepatocellular carcinoma.


Recurrent Adult Liver Carcinoma

A hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and has recurred after a period of remission.


Grade 3 Joint Infection, CTCAE

Arthroscopic intervention indicated (e.g., drainage) or arthrotomy (e.g., open surgical drainage)


Grade II Prostatic Intraepithelial Neoplasia

High grade prostatic intraepithelial neoplasia characterized by the presence of moderate architectural and cytologic abnormalities.


recurrent childhood acute myeloid leukemia

The reemergence of acute myeloid leukemia in childhood after a period of remission.


Testicular Tumor of the Thecoma/Fibroma Group

A group of rare, slow-growing stromal tumors that arise from the testis.  This category includes thecoma and fibroma.


Testicular Signet Ring Stromal Tumor

An extremely rare tumor that arises from the testis. It is characterized by the proliferation of epithelioid cells with signet ring appearance separated by fibrous tissue into trabeculae and nests. The histologic features are bland and there is no mucin production. Mutations of CTNNB1 gene have been identified in the reported cases. It is considered a special type of sex cord-stromal tumor. All reported cases had a benign clinical course without metastases.


Grade 4 Uterine Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Childhood Unfavorable Prognosis Hodgkin Lymphoma

A Hodgkin lymphoma with unfavorable prognosis that occurs during childhood.


Acquired Factor III Deficiency

An acquired coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Factor III deficiency

A coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Factor III Inactivation

Presence of inactivating antibodies to tissue factor (factor III) in the blood.


Hereditary Factor III Deficiency

An autosomal recessive, inherited coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Grade 4 Nodal or Junctional Rhythm, CTCAE


Acardius

A severe form of twin-twin transfusion syndrome that occurs in monochorionic pregnancies. The normal twin (pump twin) supplies the blood flow to its sibling that lacks heart or brain or both (acardiac/acephalic twin). Untreated, it may lead to the demise of the pump twin in some cases.


Suture Abrasion

Wearing away of the surface of a suture as a result of bending and frictional forces.


skin abrasion

Superficial damage to the skin caused by rubbing or scraping.


Grade 5 Necrotizing Enterocolitis, AE

A necrotizing enterocolitis adverse event in a newborn which results in death.


Grade 3 Jugular Vein Intra-Operative Injury, CTCAE


Benign neoplasm of supraglottis

A non-metastasizing neoplasm that arises from the supraglottis.


Childhood Acute Myeloid Leukemia without Maturation

An acute myeloid leukemia without maturation occurring in children.


Grade 3 Tracheal Fistula, CTCAE

Invasive intervention indicated


Pulmonary and Upper Respiratory Fistula, CTCAE


Grade 3 Laryngeal Fistula, CTCAE

Invasive intervention indicated


Grade 1 Oral Cavity Pulmonary Fistula, CTCAE


Grade 2 Laryngeal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 3 Oral Cavity Pulmonary Fistula, CTCAE


Laryngeal Fistula, CTCAE

A disorder characterized by an abnormal communication between the larynx and another organ or anatomic site.


Grade 4 Pharynx Pulmonary Fistula, CTCAE


Grade 4 Oral Cavity Pulmonary Fistula, CTCAE


Tracheal Fistula, CTCAE

A disorder characterized by an abnormal communication between the trachea and another organ or anatomic site.


Grade 5 Laryngeal Fistula, CTCAE

Death


Grade 5 Oral Cavity Pulmonary Fistula, CTCAE


Grade 5 Pharynx Pulmonary Fistula, CTCAE


Grade 3 Pharynx Pulmonary Fistula, CTCAE


Grade 1 Laryngeal Fistula, CTCAE

Asymptomatic


Grade 1 Tracheal Fistula, CTCAE

Asymptomatic


Grade 2 Pharynx Pulmonary Fistula, CTCAE


Grade 1 Pharynx Pulmonary Fistula, CTCAE


Parasite-Related Carcinoma

A term that refers to a group of carcinomas that are caused by parasites.


Schistosoma Hematobium-Related Bladder Squamous Cell Carcinoma

A squamous cell carcinoma of the bladder that is caused by Schistosoma hematobium.


Schistosoma Hematobium-Related Bladder Verrucous Carcinoma

A verrucous squamous cell carcinoma of the bladder that is caused by Schistosoma hematobium.


Metastatic malignant neoplasm to choroid

A malignant neoplasm that has spread to the choroid from another anatomic site.


Gallbladder Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the gallbladder.


Maxillofacial Chondroblastoma

A benign chondroid-producing neoplasm arising in a maxillofacial bone.


Osteochondromyxoma

A rare benign chondroid and osteoid matrix-producing neoplasm of bone characterized by extensive myxoid changes.  It may be a locally destructive neoplasm and has been reported in patients with Carney complex.


Laryngeal Chondroma

A benign neoplasm arising from hyaline cartilage of the larynx. It is characterized by the presence of chondrocytes, a lobulated growth pattern, and calcification.


Maxillofacial Chondroma

A benign neoplasm of hyaline cartilage that arises within the medullary cavity of a maxillofacial bone. It is characterized by the presence of chondrocytes, a lobulated growth pattern, and calcification.


Maxillofacial Chondromyxoid Fibroma

An uncommon benign cartilaginous neoplasm arising in a maxillofacial bone. It is characterized by the presence of spindle-shaped or stellate chondrocytes, a lobulated growth pattern, myxoid stroma formation, and sometimes multinucleated giant cells.


Chondromatosis

A multifocal benign neoplasm arising from bone or soft tissue.  It is characterized by the presence of chondrocytes and is composed of hyaline cartilage.


Bizarre parosteal osteochondromatous proliferation

A benign lesion that usually affects the proximal small bones of the hands or feet.  Grossly it consists of a cartilage cap and a bony stalk.  Microscopically it is characterized by the presence of spindle cells, cartilage, and bone, usually in a disorganized pattern compared to subungual exostosis.  Enlarged (bizarre) chondrocytes are present in the cartilage.  Swelling with or without pain is present.  Recurrences following resection have been reported in approximately half of cases.


Solitary Osteochondroma

An osteochondroma affecting a single anatomical site.


hemisuccinate

A succinate ester in which only one of the carboxy groups of succinic acid has been esterified.


Tactile Disorder

Conditions characterized by an alteration in the ability to perceive touch.


Uterine Obstruction

Blockage of the uterine outlet. Causes include uterine tumors and adhesions.


Refractory Lymphoma

A lymphoma that does not respond to treatment.


Refractory Central Nervous System Lymphoma

Central nervous system lymphoma that is resistant to treatment.


Refractory Primary Cutaneous Lymphoma

Primary cutaneous lymphoma that does not respond to treatment.


Refractory EBV-Related Lymphoma

EBV-related lymphoma that is resistant to treatment.


Hodgkin's disease mixed cellularity refractory

Mixed cellularity classic Hodgkin lymphoma that is resistant to treatment.


Classical Hodgkin lymphoma refractory

Classic Hodgkin lymphoma that is resistant to treatment.


Refractory Primary Bone Lymphoma

Primary lymphoma of bone that is resistant to treatment.


Refractory Hodgkin Lymphoma

Hodgkin lymphoma resistant to treatment


Hodgkin's disease nodular sclerosis refractory

Nodular sclerosis classic Hodgkin lymphoma that is resistant to treatment.


Refractory Lymphocyte-Rich Classic Hodgkin Lymphoma

Lymphocyte-rich classic Hodgkin lymphoma that does not respond to treatment.


Hodgkin's disease lymphocyte depletion type refractory

Lymphocyte-depleted classic Hodgkin lymphoma that is resistant to treatment.


Laryngeal Neuroendocrine Tumor G1

A well-differentiated, low grade neuroendocrine neoplasm that arises from the larynx.


Head and Neck Neuroendocrine Tumor

A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the head and neck.


Head and Neck Neuroendocrine Tumor G2

A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the head and neck.


Laryngeal Neuroendocrine Tumor

A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the larynx.


Head and Neck Neuroendocrine Tumor G1

A well-differentiated, low grade neuroendocrine neoplasm that arises from the head and neck.


Laryngeal Neuroendocrine Tumor G2

A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the larynx.


Grade 4 Intestinal Stoma Obstruction, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Vitamin D4

It is present in mushrooms.


1alpha,25-dihydroxy-22-oxavitamin D3 3-hemiglutarate/1alpha,25-dihydroxy-22-oxacholecalciferol 3-hemiglutarate


previtamin D3

A hydroxy seco-steroid which is an intermediate in the production of vitamin D3 in human skin.


23(S),25-dihydroxy-24-oxovitamin D3

A hydroxycalciol that is 25-hydroxyvitamin D3 carrying an additional hydroxy group at position 23 (with 23S-configuration) and an oxo group at position 24. An intermediate in the degradation pathway of 25-OH-vitamin D3.


(20S,24S)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 and 24 (both with S-configuration).


(5Z)-1alpha,25-dihydroxy-3-deoxy-3-thiavitamin D3 3-oxide/(5Z)-1alpha,25-dihydroxy-3-deoxy-3-thiacholecalciferol 3-oxide


calcidiol 3-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 3 has been replaced by a beta-D-glucuronyl residue.


1,24(S)-Dihydroxyvitamin D2

Metabolite of vitamin D2. It  present in the circulation of humans, cows, and rats given pharmacologic doses of vitamin D2


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity.


(20S)-hydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying an additional hydroxy group at position 20 with S-configuration.


A hydroxycalciol that is calciol with an additional hydroxy group at position C-1 and an acetoxy group at C-18.


(20S,23)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 23.


1alpha-hydroxy-25,26,27-trinorvitamin D3 24-carboxylic acid


(23S,25R)-25-hydroxyvitamin D3 26,23-lactol/(23S,25R)-25-hydroxycholecalciferol 26,23-lactol


A vitamin D in which the side-chain at position 17 consists of a (5R)-5-ethyl-6-methylheptan-2-yl group.


1alpha,25-Dihydroxyvitamin D3 25-trimethylsilyl ether


1alpha,2beta,25-trihydroxy vitamin D3

A hydroxy seco-steroid that is calciol carrying three additional hydroxy substituents at positions 1alpha, 2beta and 25.


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity


D3 vitamins

A vitamin D that is calciol or its hydroxylated metabolites calcidiol and calcitriol. Calciol (also known as vitamin D3) acts as a hormone precursor, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.


A hydroxycalciol that is calcitriol with an acetoxy group at C-18.


25-Hydroxyvitamin D2

A hydroxycalciol that is vitamin D2 in which the hydrogen at position 25 has been replaced by a hydroxy group.


5,6-trans-Vitamin D3

A member of the class of D3 vitamins that is calciol in which the double bond at position 5 adopts a trans-configuration. During exposure to sunlight, previtamin D3 and vitamin D3 in the skin become photoisomerized to 5,6-trans-vitamin D3.


(20S,24R)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration) and 24 (with R-configuration).


20(S),25-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 25.


Ercalcitriol

A hydroxycalciol that is vitamin D2 bearing additional hydroxy substituents at positions 1alpha and 25.


A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 25 has been replaced by a beta-D-glucuronyl residue.


Grade 2 Jejunal Obstruction, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Grade 2 Head Soft Tissue Necrosis, CTCAE

Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Splenic Plasmacytoma

A plasmacytoma that arises in the spleen.


Splenic B-Cell Lymphoma/Leukemia, Unclassifiable

A small B-cell clonal lymphoproliferative disorder of the spleen that does not fall into any of the other categories of mature B-cell neoplasms.


Malignant Splenic Soft Tissue Neoplasm

A malignant soft tissue neoplasm that arises from the spleen.


Recurrent Hairy Cell Leukemia Variant

The reemergence of hairy cell leukemia variant after a period of remission.


Splenic Manifestation of Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Infiltration and expansion of the red pulp and sinusoids of the spleen by chronic myelogenous leukemia, BCR-ABL1 positive.


Splenic Manifestation of B-Cell Prolymphocytic Leukemia

Infiltration and expansion of the white and red pulp of the spleen by B-cell prolymphocytic leukemia.


Extramedullary Disease in Plasma Cell Myeloma Involving the Spleen

Infiltration of the spleen by malignant (clonal) plasma cells in patients with history of plasma cell myeloma


Splenic Manifestation of T-Cell Prolymphocytic Leukemia

Infiltration and expansion of the white and red pulp of the spleen by T-cell prolymphocytic leukemia.


Malignant lymphoma of spleen

A non-Hodgkin lymphoma or rarely Hodgkin lymphoma that arises from the spleen.


Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia

Infiltration and expansion of the red pulp cords and sinusoids of the spleen by T-cell large granular lymphocyte leukemia. The white pulp of the spleen is not involved and is often hyperplastic.


thiazolidinediones

A thiadiazolidine in which the 1,3-thiazolidine ring is substituted by two oxo groups.


Paratesticular Paraganglioma

An extremely rare paraganglioma that arises from the paratesticular structures.


Myeloid Neoplasms with Germline Predisposition Associated with Other Organ Dysfunction

Familial myeloid neoplasms associated with germline mutations and a preexisting disorder or organ dysfunction other than a platelet disorder.


Myeloid Neoplasms with Germline Predisposition Associated with Inherited Bone Marrow Failure Syndromes

Familial myelodysplastic syndromes/ acute myeloid leukemias associated with inherited bone marrow failure syndromes.


Myeloid Neoplasms with Germline GATA2 Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline GATA2 mutation.


Myeloid Neoplasms with Germline SAMD9 Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9 mutation.


Myeloid Neoplasms with Germline SAMD9L Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9L mutation.


Myeloid Proliferations Associated with Down Syndrome

Myeloid neoplasms occurring in individuals with Down syndrome.  There is an increased risk of acute leukemias in both children and adults with Down syndrome.  In particular, the incidence of acute myeloid leukemia in Down syndrome children of less than five years of age is particularly high, it is usually an acute megakaryoblastic leukemia, and is associated with GATA1 gene mutation.  This group of disorders also includes the entity transient abnormal myelopoiesis which occurs in neonates and is associated with GATA1 gene mutation.


Myeloid Neoplasms with Germline Predisposition Associated with Telomerase Biology Disorders

Familial myelodysplastic syndromes/ acute myeloid leukemias associated with telomerase biology disorders.


Serous Tubal Intraepithelial Lesion

A non-invasive, precursor epithelial proliferation that arises from the fallopian tube, lacks severe atypia, and demonstrates serous differentiation.


Fracture of Ulna Related to Birth

A broken ulna sustained during the birthing process.


Closed Monteggia's fracture

Proximal radial head dislocation in association with a proximal ulnar fracture that does not involve a break in the adjacent skin.


Fracture of Clavicle Related to Birth

An injury sustained during the birthing process in which the continuity is broken in the clavicle.


Fracture of Femur Related to Birth

A broken femur sustained during the birthing process.


Closed fracture of rib

A traumatic break in one of the bones in the rib cage that does not involve a break in the adjacent skin.


Fracture of metacarpal bone

A traumatic break in one or more of the metacarpal bones.


Closed fracture of shaft of metacarpal bone

A traumatic break in the diaphysis of the metacarpal bone that does not involve a break in the adjacent skin.


Closed fracture of multiple ribs

A traumatic break in two or more places in one rib, or a traumatic break in more than one rib, that does not involve a break in the adjacent skin.


Closed fracture of pelvis

A traumatic break in one or more of the bones comprising the bony structure of the pelvis that does not involve a break in the adjacent skin.


Open fracture of rib

A traumatic break in one of the bones in the rib cage  that involves a break in the adjacent skin.


Closed fracture of metacarpal bone

A traumatic break in one or more of the metacarpal bones that does not involve a break in the adjacent skin.


Fracture of mandible, closed

A traumatic break in the mandible  that does not involve a break in the adjacent skin.


Closed fracture of malar AND/OR maxillary bones

A traumatic break in the malar and maxillary bones  that does not involve a break in the adjacent skin.


Fracture Related to Birth

A broken bone sustained during the birthing process.


Closed fracture of neck of metacarpal bone

A traumatic break in the area of the metacarpal bone located between the diaphysis and the distal metaphysis that does not involve a break in the adjacent skin.


Fracture of bone involving growth plate

A traumatic break in a long bone that involves the epiphyseal plate.


Lumbar vertebral fracture L2

A traumatic break in the second lumbar spinal vertebra.


Fracture of Humerus Related to Birth

A broken humerus sustained during the birthing process.


Fracture of phalanx of finger

A traumatic break in one or more of the bones in one of the digits of the hand.


Open fracture of neck of metacarpal bone

A traumatic break in the area of the metacarpal bone located between the diaphysis and the distal metaphysis that involves a break in the adjacent skin.


Closed Colles' fracture

An extra-articular traumatic break in the distal radius with dorsal displacement of the distal fragment that does not involve a break in the adjacent skin.


Fracture of Spine Related to Birth

A broken vertebra sustained during the birthing process.


Fracture of Radius Related to Birth

A broken radius sustained during the birthing process.


Colles' Fracture

An extra-articular traumatic break in the distal radius with dorsal displacement of the distal fragment.


Open fracture of pelvis

A traumatic break in one or more of the bones comprising the bony structure of the pelvis that involves a break in the adjacent skin..


Fracture of Skull Related to Birth

An injury sustained during the birthing process in which the continuity is broken in the skull.


Limb fracture

A traumatic break in one or more bones in a limb.


Open fracture of metacarpal bone

A traumatic break in one or more of the metacarpal bones that involves a break in the adjacent skin.


Fracture of Nose Related to Birth

A broken nasal bone sustained during the birthing process.


Grade 2 Vaginal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Parotid Gland Lymphangioma

A lymphangioma arising from the parotid gland.


dichlorobenzene

Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.


Isoconazole

A member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1.


(S)-fenticonazole

A 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole that is the (S)-enantiomer of fenticonazole.


A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of econazole.


(S)-butoconazole

The (S)-enantiomer of butoconazole.


(S)-Tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of tioconazole.


A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of econazole.


clonidine (amino form)

A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.


Fenticonazole, (R)-

A 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole that is the (R)-enantiomer of fenticonazole.


(S)-Miconazole

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has S) configuration.


(S)-Enilconazole

A 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that is the (S)-enantiomer of enilconazole


(R)-Enilconazole

A 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that is the (R)-enantiomer of enilconazole.


Arasertaconazole

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the active R-enantiomer of sertaconazole and is used (as its nitrate salt) for treatment of vulvovaginal candidiasis. The racemate itself is also used as a broad-spectrum antifungal drug.


(R)-butaconazole

The (R)-enantiomer of butaconazole.


(R)-Miconazole

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has R configuration.


A salicylanilide derivative with chloride substituents at C-3 and C-5 of the salicylate moiety and at C-3 and C-4 of the anilide moiety.


(R)-Tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of tioconazole.


(S)-Sertaconazole

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of sertaconazole.


A pyrazolylpiperidine that consists of 4-(pyrazol-1-yl)piperidine carrying a 2-amino-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-5-yl group at the 4-position of the pyrazole ring.


Stage IV Adrenal Cortex Carcinoma AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


A sympathetic paraganglioma arising from the retroperitoneum, outside the adrenal gland.


Retroperitoneal Ganglioneuroma

A ganglioneuroma arising from the retroperitoneum.


Adrenal Cortical Carcinoma by AJCC v7 Stage

A term that refers to the staging of adrenal cortical carcinoma, following the rules of the TNM AJCC v7 classification system.


Adrenal Cortical Oncocytic Carcinoma

A carcinoma that arises from the adrenal cortex and is composed of oncocytic cells that constitute more than 90% of malignant cells.


Stage III Adrenal Cortex Carcinoma AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0); (T4, Any N, M0). T1: Tumor measuring 5 cm or less in greatest dimension, with no extra-adrenal invasion. T2: Tumor measuring more than 5 cm in greatest dimension, with no extra-adrenal invasion. T3: Tumor of any size with local invasion but not invading adjacent organs. T4: Tumor of any size that invades adjacent organs (kidney, diaphragm, pancreas, spleen, or liver) or large blood vessels (renal vein or vena cava). N1: Metastasis in regional lymph node(s). M0: No distant metastasis. (from AJCC 8th Ed.)


Adrenal Cortical Carcinoma by AJCC v8 Stage

A term that refers to the staging of adrenal cortical carcinoma, following the rules of the TNM AJCC v8 classification system. Adrenal medullary pheochromocytoma is staged according to the classification for adrenal neuroendocrine tumors. There is no AJCC staging system for neuroblastic tumors of the adrenal gland. (from AJCC 8th Ed.)


Adrenal Cortical Oncocytic Adenoma

A usually non-functioning variant of adrenal cortex adenoma, composed of large cells with abundant granular eosinophilic cytoplasm.


Glomerulosa Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of neoplastic cells with cytologic features of glomerulosa cells.


Stage III Adrenal Cortex Carcinoma AJCC v7

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0).  T1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion.  T2: Tumor greater than 5 cm, no extra-adrenal invasion.  T3: Tumor of any size with local invasion, but not invading adjacent organs.  N1: Metastasis in regional lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adrenal Gland Ganglioneuroma

A ganglioneuroma arising from the adrenal gland.


Adrenal Gland Lipoma

A rare lipoma that arises from the adrenal gland.


Recurrent Adrenal Gland Pheochromocytoma

The reemergence of pheochromocytoma following surgical removal.


Clear Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of neoplastic clear cells containing intracytoplasmic lipid droplets.


Stage IV Adrenal Cortex Carcinoma AJCC v7

Stage IV includes: (T3, N1, M0); (T4, N0, M0); (T4, N1, M0); (Any T, Any N, M1).  T3: Tumor of any size with local invasion, but not invading adjacent organs.  T4: Tumor of any size with invasion of adjacent organs.  N1: Metastasis in regional lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. M1: Distant metastasis.  (AJCC 7th ed.)


Retroperitoneal Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor that arises from the retroperitoneum. This is an extragastrointestinal tumor, meaning that it does not arise directly from the gastrointestinal tract.


Leiomyoma of the adrenal gland

A rare leiomyoma that arises from the adrenal gland.


Benign neoplasm of retroperitoneum

A non-metastasizing neoplasm that arises from the retroperitoneum.


Benign neoplasm of adrenal cortex

A non-metastasizing neoplasm arising from the adrenal cortex.


Stage I Adrenal Cortex Carcinoma AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Familial Adrenal Gland Pheochromocytoma

A familial adrenal gland pheochromocytoma caused by mutations in SDHB, SDHC, and SDHD genes.


Adrenal Cortical Adenomatoid Tumor

A benign adrenal cortical neoplasm deriving from mesothelial cells.


Locally Advanced Adrenal Gland Pheochromocytoma

Adrenal gland pheochromocytoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adrenal Cortical Myxoid Carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the presence of abundant extracellular connective tissue mucin.


Locally Advanced Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adrenal Gland Lymphangioma

A rare lymphangioma that arises from the adrenal gland.


Stage II Adrenal Cortex Carcinoma AJCC v7

Stage II includes: T2, N0, M0.  T2: Tumor greater than 5 cm, no extra-adrenal invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adrenal Gland Lymphoma

A rare lymphoma that arises from the adrenal gland.


Adrenal Cortical Low Grade Carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the presence of twenty or less mitoses per ten square millimeters.


Metastatic Adrenal Gland Composite Pheochromocytoma

An adrenal gland composite pheochromocytoma that metastasizes to other anatomic sites.


Metastatic Adrenal Cortical Carcinoma

A carcinoma that arises from the adrenal cortex and has metastasized to another anatomic site.


Adrenal Gland Hemangioma

A rare hemangioma that arises from the adrenal gland.


Superior and Inferior Paraaortic Paraganglioma

An extra-adrenal sympathetic paraganglioma arising from paraganglia located along the aorta, including suprarenal, infrarenal, and renal hilar sites.  In functional tumors, the hypersecretion of catecholamines results in hypertension.


Metastatic Carcinoma in the Adrenal Cortex

A carcinoma that has spread to the adrenal cortex from an adjacent or distal anatomic site.


Androgen-Producing Adrenal Cortical Adenoma

A rare adenoma of the adrenal cortex that produces androgens.  Female patients usually have symptoms related to virilism.


Unresectable Adrenal Gland Pheochromocytoma

Adrenal gland pheochromocytoma that is not amenable to surgical resection.


Compact Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of neoplastic compact cells with eosinophilic cytoplasm.


Adrenal Cortical Sex Cord-Stromal Tumor

An extremely rare sex cord-stromal tumor that arises from the adrenal cortex. The reported cases were solitary and unilateral.


Adrenal Gland Composite Pheochromocytoma

A neoplasm that arises from the adrenal medulla and combines morphologic characteristics of pheochromocytoma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor.


Adrenal Gland Ganglioneuroblastoma, Intermixed

An intermixed ganglioneuroblastoma arising from the adrenal gland.


Adrenal Cortical High Grade Carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the presence of more than twenty mitoses per ten square millimeters.


Stage I Adrenal Cortex Carcinoma AJCC v8

Stage I includes: T1, N0, M0. T1: Tumor measuring 5 cm or less in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Advanced Adrenal Gland Pheochromocytoma

An adrenal gland pheochromocytoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adrenal Cortical Melanoma

A rare melanoma that arises within the adrenal cortex.


Adrenal Gland Schwannoma

A rare schwannoma that arises from the adrenal medulla.


Mixed Cell Adrenal Cortical Adenoma

An adenoma of the adrenal cortex composed of a mixed neoplastic cellular population, including varying numbers of neoplastic clear and compact cells.


Stage II Adrenal Cortex Carcinoma AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor measuring more than 5 cm in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Adrenal Gland Ganglioneuroblastoma, Nodular

A nodular ganglioneuroblastoma arising from the adrenal gland.


Unresectable Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that is not amenable to surgical resection.


Recurrent Malignant Retroperitoneal Neoplasm

The reemergence of a malignant retroperitoneal neoplasm after a period of remission.


Non-Metastatic Adrenal Gland Composite Pheochromocytoma

A composite pheochromocytoma that is confined to the adrenal gland.


Regional Adrenal Gland Pheochromocytoma

A pheochromocytoma that has not spread to other regions.


Heavily Pigmented Adrenal Cortical Adenoma

A usually functioning adenoma of the adrenal cortex. Grossly, it has a dark brown appearance and is characterized by the presence of neoplastic cells containing abundant intracytoplasmic lipofuscin. It may be associated with Cushing syndrome.


Recurrent Adrenal Cortical Carcinoma

The reemergence of adrenal cortical carcinoma after a period of remission.


Anaplastic adrenocortical carcinoma

A carcinoma that arises from the adrenal cortex and is characterized by the partial or complete loss of adrenal cortical differentiation.


Refractory Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that is resistant to treatment.


estrogen-producing adrenal cortical adenoma

A rare adenoma of the adrenal cortex that produces estrogens.  Male patients may develop gynecomastia and impotence.


Grade 1 Conjunctivitis, CTCAE

Asymptomatic or mild symptoms; intervention not indicated


Grade 5 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Forceps Injury

Birth injury sustained during a forceps-assisted delivery.


Grade 5 Pericardial Tamponade, CTCAE

Death


Grade 1 Upper Extremity Vein Injury, CTCAE


Grade 4 Upper Extremity Vein Injury, CTCAE


Grade 2 Upper Extremity Vein Injury, CTCAE


Grade 5 Upper Extremity Vein Injury, CTCAE


Familial Adenomatous Polyposis Associated Medulloblastoma

A medulloblastoma developing in patients with familiar adenomatous polyposis syndrome.  It is observed in patients with Turcot syndrome, type 2.


Sellar Neuroblastoma

A rare neuroblastoma arising from the sella turcica.


Refractory Ganglioneuroblastoma

Ganglioneuroblastoma that does not respond to treatment.


Embryonal Tumor with Multilayered Rosettes, DICER1-Mutated

An embryonal tumor with multilayered rosettes characterized by the presence of DICER1 mutation. Approximately half of embryonal tumors with multilayered rosettes that lack a C19MC alteration carry DICER1 mutations.


Refractory Dedifferentiated Chordoma

A dedifferentiated chordoma that does not respond to treatment.


Refractory Rhabdoid Tumor

Rhabdoid tumor that does not respond to treatment.


Familial Neuroblastoma

Genetic inheritance of neuroblastoma caused by mutations in the ALK or PHOX2B genes.  Familial neuroblastomas have a higher incidence of multiple primary tumors and are diagnosed at an earlier age.


Childhood Central Nervous System Ganglioneuroblastoma

A cerebral ganglioneuroblastoma that occurs during childhood.


Advanced Chordoma

A chordoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Central Nervous System Embryonal Tumor, Not Otherwise Specified with Leptomeningeal Spread

A central nervous system embryonal tumor, not otherwise specified which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.


Visual Pathway Medulloepithelioma

A very rare, benign or malignant embryonal neoplasm affecting the visual pathway during childhood. It arises from primitive medullary epithelium.


nodular medulloblastoma

A medulloblastoma characterized by nodularity and neuronal differentiation.


Neuroblastoma of the Adrenal Gland and Sympathetic Nervous System

A common pediatric extracranial tumor arising from neural crest cells.  It involves the adrenal medulla and the sympathetic nervous system.


Adult Supratentorial Embryonal Tumor, Not Otherwise Specified

A supratentorial embryonal tumor, not otherwise specified that occurs in adults.


An intermixed ganglioneuroblastoma that occurs during childhood.


Anaplastic Medulloblastoma

A medulloblastoma characterized by marked nuclear pleomorphism, and high mitotic activity.


Paratesticular Wilms Tumor

A rare Wilms tumor that arises from the paratesticular structures.


Prostate Wilms Tumor

A rare Wilms tumor affecting the prostate gland.


Childhood Atypical Teratoid/Rhabdoid Tumor

An atypical teratoid/rhabdoid tumor occurring in children.


medulloblastoma SHH activated and TP53 mutant

Medulloblastoma associated with activation of the sonic hedgehog (SHH) pathway and the presence of TP53 mutations.


Localized Resectable Neuroblastoma

Neuroblastoma that is confined to a specific site and is amenable to surgical removal.


Refractory Peripheral Primitive Neuroectodermal Tumor

Peripheral primitive neuroectodermal tumor that does not respond to treatment.


Recurrent Rhabdoid Tumor

The reemergence of rhabdoid tumor after a period of remission.


Thyroblastoma

A high-grade, rapidly growing malignant embryonal neoplasm that arises from the thyroid gland. It is characterized by the presence of primitive follicular-like structures surrounded by primitive small cells and primitive spindle cell mesenchymal stroma. It is associated with DICER1 gene mutations. The prognosis is poor.


Extra-osseous Ewing's sarcoma recurrent

Reemergence of extraskeletal Ewing sarcoma after a period of remission.


Peripheral neuroepithelioma of bone metastatic

A small round cell tumor of the bone with neural differentiation that has spread from its original site of growth to another anatomic site.


Unresectable Ewing Sarcoma

A Ewing sarcoma which is not amenable to surgical resection.


Central Nervous System Embryonal Neoplasm

A malignant neoplasm of embryonal origin, arising from the central nervous system.  It usually affects children.  Representative examples include ependymoblastoma, medulloblastoma, and atypical teratoid/rhabdoid tumor.


Locally Advanced Ewing Sarcoma

Ewing sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Sellar Dedifferentiated Chordoma

A dedifferentiated chordoma that arises from the sellar region.


Recurrent Childhood Central Nervous System Embryonal Neoplasm

The reemergence of childhood central nervous system embryonal neoplasm after a period of remission.


Resectable Neuroblastoma

Neuroblastoma that is amenable to surgical resection.


High Risk Neuroblastoma

Neuroblastoma usually presenting with metastatic disease and MYCN gene amplifications.


embryonal tumor with multilayered rosettes

A central nervous system embryonal tumor characterized by the presence of multilayered rosette formation and typically the presence of amplification of the C19MC region on chromosome 19 (19q13.42) or rarely a DICER1 mutation.


Peripheral neuroepithelioma of bone recurrent

The reemergence of peripheral primitive neuroectodermal tumor of the bone after a period of remission.


Cribriform Neuroepithelial Tumor

A very rare, nonrhabdoid, intraventricular tumor with relatively favorable prognosis.  It is characterized by the presence of neuroepithelial cells forming cribriform patterns, trabeculae, epithelial membrane antigen immunopositivity on epithelial surfaces, and loss of nuclear INI 1 expression.


Sellar Chordoma

A chordoma that arises from the sellar region.


The reemergence of medulloblastoma, WNT-activated after a period of remission.


Stage 3 Neuroblastoma

Unresectable unilateral tumor infiltrating across the midline, with or without regional lymph node involvement; or localized unilateral tumor with contralateral regional lymph node involvement; or midline tumor with bilateral extension by infiltration (unresectable) or by lymph node involvement. The midline is defined as the vertebral column. Tumors originating on one side and crossing the midline must infiltrate to or beyond the opposite side of the vertebral column. (cancer.gov)


Refractory Atypical Teratoid/Rhabdoid Tumor

An atypical teratoid/rhabdoid tumor that does not respond to treatment.


Stage 4S neuroblastoma

Localized primary tumor, as defined for stage 1, 2A, or 2B, with dissemination limited to skin, liver, and/or bone marrow (limited to infants younger than 1 year). Marrow involvement should be minimal (i.e., <10% of total nucleated cells identified as malignant by bone biopsy or by bone marrow aspirate). More extensive bone marrow involvement would be considered stage 4 disease. The results of the MIBG scan, if performed, should be negative for disease in the bone marrow. (cancer.gov)


Medulloblastoma with Leptomeningeal Spread

A medulloblastoma which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.


Unresectable Rhabdoid Tumor

A rhabdoid tumor that is not amenable to surgical resection.


Stage IV Kidney Wilms Tumor

Wilms tumor that has spread to other more distant organs, such as the lungs, liver, bones, and brain, or to lymph nodes outside the abdomen (National Wilms Tumor Study Group Staging System)


Poorly Differentiated Neuroblastoma

A neuroblastoma in which the differentiating neuroblasts constitute less than five-percent of the tumor cells.


Skin Ewing Sarcoma

A rare Ewing sarcoma that arises from the skin.


Recurrent Atypical Teratoid/Rhabdoid Tumor

The reemergence of an atypical teratoid/rhabdoid tumor after a period of remission.


Unresectable Chordoma

A chordoma which is not amenable to surgical resection.


Ciliary Body Teratoid Medulloepithelioma

A rare, unilateral, benign or malignant embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium and contains heterologous elements, particularly cartilage, skeletal muscle, and brain tissue.


Undifferentiated Neuroblastoma

A neuroblastoma characterized by the absence of differentiating neuroblasts.


Stage 2 Neuroblastoma

Stage 2 includes stage 2A and stage 2B.  Stage 2A: Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph nodes negative for tumor microscopically. Stage 2B: Localized tumor with or without complete gross excision, with ipsilateral nonadherent lymph nodes positive for tumor. Enlarged contralateral lymph nodes must be negative microscopically. (cancer.gov)


Locally Advanced Chordoma

A chordoma that has spread from its original site of growth to nearby tissues.


Regional Neuroblastoma

A neuroblastoma confined to a specific anatomic region without evidence of dissemination.


Extrarenal Rhabdoid Tumor of the Prostate

A rare extrarenal rhabdoid tumor affecting the prostate gland.


Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

A malignant small round cell tumor with or without neural differentiation that is resistant to treatment.


Unresectable Neuroblastoma

Neuroblastoma which is not amenable to surgical resection.


Stage 2A Neuroblastoma

Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph nodes negative for tumor microscopically. (cancer.gov)


Sinonasal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the nasal cavity and paranasal sinuses.


Medulloblastoma, Molecularly Defined

A term that refers to the classification of medulloblastomas according to their molecular characteristics.


Metastatic Neuroblastoma

A neuroblastoma that has metastasized from its original site of growth to another anatomic site.


Recurrent Childhood Medulloblastoma

The reemergence of childhood medulloblastoma after a period of remission.


Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified

A supratentorial embryonal tumor, not otherwise specified that occurs in childhood.


Extra-osseous Ewing's sarcoma non-metastatic

Ewing sarcoma that arises from the soft tissue and is confined to a specific site without evidence of spread to other anatomic sites.


Medulloblastoma, Not Otherwise Specified

A medulloblastoma which has not been further characterized.


Benign medulloepithelioma of ciliary body

A rare, unilateral, benign embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium.


Recurrent tumors of the Ewing's family

The reemergence of a malignant small round cell tumor with or without neural differentiation after a period of remission.


Malignant medulloepithelioma of ciliary body

A rare, unilateral, malignant embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium.


Recurrent Primitive Neuroectodermal Tumor

The reemergence of a primitive neuroectodermal tumor of the central or the peripheral nervous system after a period of remission.


Anaplastic Kidney Wilms Tumor

Wilms tumor of the kidney characterized by the presence of nuclear anaplasia.  Anaplasia is defined by the presence of all of the following: multipolar polyploid mitotic figures, marked nuclear enlargement, and hyperchromasia.  When anaplasia is diffuse, it is associated with an unfavorable clinical outcome.


Disseminated neuroblastoma

Any primary tumor with dissemination to distant lymph nodes, bone, bone marrow, liver, skin, and/or other organs, except as defined for stage 4S. (cancer.gov)


Stage II Kidney Wilms Tumor

Wilms tumor that is found in the kidney and in the fat, soft tissue, or blood vessels near the kidney. It may have spread to the renal sinus. The renal sinus is the part of the kidney where blood and fluid enter and exit the organ. The tumor can be completely removed with surgery. (National Wilms Tumor Study Group Staging System)


Localized Askin Tumor

A small round cell tumor confined to a specific area of the thoracic cavity without evidence of spread to other anatomic sites.


Recurrent Kidney Wilms Tumor

The reemergence of Wilms tumor of the kidney after a period of remission.


Poorly Differentiated Chordoma

A rare, aggressive type of chordoma characterized by loss of SMARCB1 expression. It affects children and occasionally young adults. Females are affected twice as frequently as males. It usually arises in the axial skeleton. It is composed of sheets or nests of malignant epithelioid cells with abundant eosinophilic cytoplasm. The prognosis is poor.


Stage III Kidney Wilms Tumor

Wilms tumor that is found in areas near the kidney and cannot be completely removed with surgery. The tumor may have spread to nearby organs and blood vessels or throughout the abdomen and to nearby lymph nodes. Lymph nodes are tiny, bean-shaped organs that help fight infection. Stage III cancer has not spread outside the abdomen. (National Wilms Tumor Study Group Staging System)


Central Nervous System Embryonal Tumor with Rhabdoid Features

A central nervous system embryonal neoplasm characterized by the presence of histological features consistent with atypical teratoid/rhabdoid tumor and absence of mutations of the INI1 gene or SMARCA4 (BRG1) gene.


Central Nervous System Embryonal Tumor, Not Elsewhere Classified

A central nervous system embryonal tumor lacking molecular abnormalities that would classify it as one of the molecularly defined central nervous system embryonal neoplasms.


Refractory Wilms Tumor

Wilms tumor that is resistant to treatment.


Childhood Ganglioneuroblastoma, Nodular

A nodular ganglioneuroblastoma that occurs during childhood.


Kadish Stage B Olfactory Neuroblastoma

An olfactory neuroblastoma that involves the nasal cavity and paranasal sinuses.


Fourth Ventricle Medulloblastoma

A medulloblastoma occurring in the fourth ventricle.


Localized Unresectable Neuroblastoma

Neuroblastoma that is confined to a specific site and is not amenable to surgical removal.


Kidney Ewing Sarcoma

A rare Ewing sarcoma arising from the kidney.


Kadish Stage A Olfactory Neuroblastoma

An olfactory neuroblastoma that is confined to the nasal cavity


Benign Notochordal Cell Tumor

An intraosseous benign tumor of notochord origin that arises in the bones of the base of the skull, vertebral bodies, sacrum or coccyx.  It contains vacuolated tumor cells without atypia, but lacks myxoid matrix, necrosis, and lobular architecture, which are features that characterize its malignant counterpart, chordoma.  Most lesions are incidental findings.


Central Nervous System Neuroblastoma, FOXR2-Activated

A rare central nervous system embryonal neoplasm with neuroblastic and/or neuronal differentiation. It is characterized by the presence of structural rearrangements of FOXR2 gene that result in the activation of the transcription factor FOXR2.


Refractory Primitive Neuroectodermal Tumor

Primitive neuroectodermal tumor that does not respond to treatment.


Metastatic Medulloblastoma

Medulloblastoma that has spread from its original site of growth to another anatomic site.


medulloblastoma non-WNT/non-SHH group 3

Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog (SHH) pathway. MYC amplifications may be present. TP53 mutations are absent. Patients in this group are usually young children. The overall survival is the worst among all the molecular groups.