Grade 4 Depressed Level of Consciousness, CTCAE

Life-threatening consequences; coma; urgent intervention indicated


Grade 4 Kidney Fistula, CTCAE

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Grade 1 Non-Malignant Pericardial Effusion, CTCAE


Grade 5 Colonic Hemorrhage, CTCAE

Death


Germ Cell Tumor (Antiquated)

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon


Virilization, CTCAE

A disorder characterized by inappropriate masculinization occurring in a female or prepubertal male.


Grade 5 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Psychosis Including Hallucinations and Delusions, CTCAE


Grade 3 Mitral Valve Disease, CTCAE

Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention


Esophageal Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures).


Grade 4 Fever, CTCAE

>40.0 degrees C (>104.0 degrees F) for >24 hrs


Grade 3 Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Grade 1 Edema of the Head and Neck, CTCAE


Acute Myeloid Leukemia with RAM Immunophenotype

A high risk pediatric acute myeloid leukemia with an extremely poor prognosis. The blasts show bright CD56 expression, dim-to-negative expression of CD45 and CD38, and lack of HLA-DR expression. This immunophenotype was named after one of the pediatric patient's initials (RAM), from Children's Oncology Group (COG) clinical trial AAML0531.


Grade 4 Cranial Nerve IV Neuropathy, CTCAE


Vaginal Endometrioid Adenocarcinoma

A rare adenocarcinoma that arises from the vagina with histologic features resembling the endometrioid adenocarcinoma of the endometrium.


Late Disseminated Lyme Disease

A late stage of Lyme disease that may present in untreated patients months to years after a tick bite manifested with intermittent bouts of arthralgia, arthritis and neurologic complaints.


Grade 4 Cardiac Ischemia or Infarction, CTCAE


Grade 4 Pulmonary Fibrosis, CTCAE

Life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing


Grade 5 Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


Cervical Squamous Cell Carcinoma, Not Otherwise Specified

Cervical squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


Chest Pain in Left Third Intercostal Space

The location of the chest pain is within the third intercostal space on the left side.


Stage IIB Prostate Cancer AJCC v7

Stage IIB includes: (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T2c: Tumor involves both lobes.  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Somnolence, CTCAE

A disorder characterized by characterized by excessive sleepiness and drowsiness.


Dialysis Catheter Infection

A local or systemic infection associated with the use of a dialysis catheter.


Grade 2 Cognitive Disturbance, CTCAE

Moderate cognitive disability; interfering with work/school/life performance but capable of independent living; specialized resources on part time basis indicated


Recurrent Pancreatic Ductal Adenocarcinoma

The reemergence of pancreatic ductal adenocarcinoma after a period of remission.


Vaginal Non-Neoplastic Disorder

A non-neoplastic disorder that affects the vagina. Representative examples include vaginal infection and vaginal fibroepithelial polyp.


Grade 4 Rectum Intra-Operative Injury, CTCAE


Grade 2 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Gastric Necrosis, CTCAE

Death


Grade 2 Chills, CTCAE

Moderate tremor of the entire body; narcotics indicated


Superficial spreading adenocarcinoma

An adenocarcinoma which has spread within the mucosa without further invasion of the underlying tissues.


Stage IV Pancreatic Neuroendocrine Tumor AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Biliary Intraepithelial Neoplasia

A neoplastic, non-invasive lesion that affects the biliary epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Large B-cell lymphoma arising in HHV8 associated multicentric Castleman disease

An aggressive diffuse large B-cell lymphoma occurring in patients with HHV8-positive multicentric Castleman disease. It is characterized by the presence of human herpesvirus 8-infected large B-lymphocytes that resemble plasmablasts. It is usually seen in patients with HIV infection.


Colonic Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the colon.


Grade 2 Fat Atrophy, CTCAE

Covering 10-30% BSA and associated with erythema or tenderness; limiting instrumental ADL


Cyst of tonsil

A cystic structure in the tonsillar tissue.


Grade 1 Atrial Fibrillation, CTCAE

Asymptomatic, intervention not indicated


Verrucous carcinoma of the oral cavity stage II


Recurrent Anaplastic Ganglioglioma

The reemergence of anaplastic ganglioglioma after a period of remission.


Adrenoleukodystrophy, Neonatal

A rare metabolic disorder that affects neonates. It is characterized by damage of the white matter in the brain and degeneration of the adrenal glands. It manifests with hyperactivity, paralysis, muscular weakness, crossed eyes, hearing loss, seizures, and coma.


Grade 2 Vulva Intra-Operative Injury, CTCAE


Grade 4 Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


Inguinal Mass

An abnormal growth in the groin.


Pancreatic Intraductal Tubulopapillary Neoplasm

An epithelial neoplasm that arises from the exocrine pancreas characterized by the formation of tubular structures, high grade dysplasia, and ductal differentiation. Grossly, it is characterized by the presence of intraductal nodular masses. Morphologically, there are nodules of tubular glands and occasional papillary structures growing in dilated ducts.  There is no significant mucin production. Signs and symptoms include epigastric pain, weight loss, vomiting, steatorrhea, and diabetes mellitus.


Grade 2 Bronchus Intra-Operative Injury, CTCAE


Cancer that is not dependent upon the presence of estrogen for metastasis or growth. 2005


Maternal Obesity

Obesity in a female who has a child.


Hirsutism, CTCAE

A disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen).


Grade 2 Throat and Pharynx and Larynx Pain, CTCAE


Grade 5 Tracheal Stenosis, CTCAE

Death


Atrophy of vagina

A condition characterized by the absence of squamous maturation in the vaginal epithelium. It is associated with decreased estrogen production.


Genital Edema, CTCAE

A disorder characterized by swelling due to an excessive accumulation of fluid in the genitals.


Jugular Vein Intra-Operative Injury, CTCAE


Stage IIIA Cervical Cancer AJCC v8

Stage IIIA includes: T3a, Any N, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 2 Hypertrichosis, CTCAE

Increase in length, thickness or density of hair at least on the usual exposed areas of the body [face (not limited to beard/moustache area) plus/minus arms] that requires frequent shaving or use of destructive means of hair removal to camouflage; associated with psychosocial impact


Stage IB2 Cervical Cancer FIGO 2009

Cervical carcinoma measuring more than 5 mm in depth and more than 4 cm in maximum diameter. (FIGO 2009)


Grade 3 Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


Anal Mucositis

An inflammatory process affecting the mucous membrane of the anus.


Grade 5 Upper Airway Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Glaucoma, CTCAE

Visual field deficit within the central 10 degrees of the visual field in the affected eye


Stage I Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

Stage I includes: T1, N0, M0. T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Recurrent Anaplastic Oligodendroglioma

The reemergence of anaplastic oligodendroglioma after a period of remission.


Prolonged grief disorder

A psychiatric disorder characterized by the personal experience of intense and prolonged yearning for, or preoccupation with the circumstances surrounding, a loss that leads to significant impairment in social or occupational functioning. Associated symptoms may include: identity disruption, disbelief, avoidance of reminders, difficulty moving on, emotional pain or numbness, feeling that life is meaningless, and loneliness.


Delayed Orgasm, CTCAE

A disorder characterized by sexual dysfunction characterized by a delay in climax.


Musculoskeletal Chest Pain due to Sternal Injury

A condition in which there is musculoskeletal chest pain secondary to trauma to the sternum. (ACC/AHA)


Stage IV Skin Melanoma

A melanoma that arises from the skin and has metastasized to another anatomic site.


Recurrent Moderate-Severe Chronic Graft Versus Host Disease

The reemergence of moderate-severe chronic graft versus host disease after a period of remission.


Decreased Peak Drug Blood Concentration

Decreased maximum (peak) concentration of a drug observed after its administration.


Locally Advanced Bone Sarcoma

Bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Factor X Inactivation

Presence of inactivating antibodies to factor X in the blood.


Grade 3 Disseminated Intravascular Coagulation, CTCAE

Laboratory findings and bleeding


Grade 3 Small Intestinal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 1 Radiation Excluding Chemoradiation, CTCAE


Grade 1 Alkaline Phosphatase Increased, CTCAE

>ULN-2.5 x ULN if baseline was normal; 2.0-2.5 x baseline if baseline was abnormal


Megaureter

Enlargement of the diameter of the ureter, which can be partial or complete.


Refractory Malignant Peripheral Nerve Sheath Tumor

Malignant peripheral nerve sheath tumor that is resistant to treatment.


Precordial Catch Syndrome

A condition in which there is musculoskeletal chest pain characterized by brief, sharp discomfort associated with inspiration. (ACC/AHA)


Seminoma, anaplastic

A seminoma of the testis characterized by increased cellular pleomorphism, high mitotic activity, and a non-prominent stromal lymphocytic infiltrate.


Grade 2 Telangiectasia, CTCAE

Telangiectasias covering >=10% BSA; associated with psychosocial impact


Cranial Nerve XI Intra-Operative Injury, CTCAE


Grade 3 Adrenal Insufficiency, CTCAE

Severe symptoms; hospitalization indicated


Grade 2 Serum Glutamic Pyruvic Transaminase, CTCAE


Euphoria, CTCAE 5.0

A disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli.


NK-lymphoblastic leukemia/lymphoma

A precursor lymphoid neoplasm that expresses CD56 and immature T-cell markers, lacks B-lymphoid and myeloid markers, and has immunoglobulin and T-cell receptor genes in the germline configuration.


Grade 4 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cervical Cancer by AJCC v6 Stage

A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 6th edition.


Borderline Ovarian Serous Surface Papillary Tumor

A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of papillary proliferations that contain atypical serous epithelial cells in the outer surface of the ovary.  There is no evidence of stromal invasion.


Classical Low Grade Fibromyxoid Sarcoma

A low grade fibromyxoid sarcoma that may have poorly formed collagen rosettes, but lacks prominent, well formed collagen rosettes.


Grade 2 Fallopian Tube Perforation, CTCAE

Invasive intervention not indicated


Male Non-Neoplastic Reproductive System Disorder

A non-neoplastic disorder that affects the male reproductive system. Representative examples include prostatitis, balanitis, and phimosis.


Localized Muscle Invasive Bladder Urothelial Carcinoma

A bladder urothelial carcinoma that has focally invaded into the bladder muscularis propria.


Intestinal Stoma Leak, CTCAE

A finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body).


Antepartum Obstetric Thromboembolism

Presence of a blood clot in the maternal vascular system which originated from a distant site during the antepartum period.


Grade 4 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


Squamous intraepithelial neoplasia grade 2


Grade 3 Penile Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Vascular Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 4 Myelitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Good Prognosis Metastatic Gestational Trophoblastic Tumor

Metastatic gestational trophoblastic tumor in which risk factors are absent.


Urothelial carcinoma urethra recurrent

The reemergence of transitional cell carcinoma in the urethra after a period of remission.


Satellite Nodule

Additional, separate neoplastic nodules surrounding a central neoplastic lesion.


Stage 0 Testicular Cancer AJCC v8

Stage 0 includes: pTis, N0, M0, S0. pTis: Testicular cancer with a finding of germ cell neoplasia in situ. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


Large Intestinal Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine.


Grade 4 Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Cranial Nerve VII Neuropathy, CTCAE


Grade 5 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cervical meningomyelocele

A congenital abnormality in the cervical region of the spine in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Refractory Monomorphic Post-Transplant Lymphoproliferative Disorder

A monomorphic post-transplant lymphoproliferative disorder that does not respond to treatment.


Grade 1 Urine Discoloration, CTCAE

Present


Pancreatic Endocrine Glucose Intolerance, CTCAE


Grade 3 Hypocalcemia, CTCAE

Corrected serum calcium of <7.0-6.0 mg/dL; <1.75-1.5 mmol/L; Ionized calcium <0.9-0.8 mmol/L; hospitalization indicated


Serum Immunoglobulin Free Light Chain Ratio Abnormal

A laboratory test result indicating an abnormal kappa to lambda ratio of immunoglobulin free light chains in the serum.


Grade 4 Thrombotic Microangiopathy, CTCAE


Grade 5 Cranial Nerve I Neuropathy, CTCAE


Stage IIA Pancreatic Cancer AJCC v6 and v7

Stage IIA includes: T3, N0, M0.  T3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 5 Adrenal Insufficiency, CTCAE

Death


Grade 2 Peripheral Nerve Infection, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Grade 3 Neonatal Bradyarrhythmia, AE

A bradyarrhythmia adverse event in a newborn resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention).


Grade 3 Neonatal Hypotension, AE

An adverse event in a newborn characterized by persistent hypotension affecting perfusion; requiring major care change (e.g. vaso-active drugs or hydrocortisone).


Intoxication

Disturbances in psychophysiological functions and responses as a result of administration or ingestion of a psychoactive substance.


Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage III includes: IIIA: (T0-2, N1, M0); IIIB: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Burn, CTCAE

Medical intervention; minimal debridement indicated


Grade 1 Perineal Pain, CTCAE

Mild pain


Non-Neoplastic Hepatobiliary Disorder

A non-neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples include hepatitis, cirrhosis, cholangitis, and cholecystitis.


Locally Advanced Digestive System Neuroendocrine Tumor G2

Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to nearby tissues or lymph nodes.


Hypophosphatemia, CTCAE

A disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood.


Induced cataract

A cataract that has been produced artificially or by induction, e.g. as a result of device use, medication, trauma, tears, falls, accidental injury, etc.


Stage IA Vulvar Cancer AJCC v7

Stage IA includes: T1a, N0, M0. T1a: Tumor confined to the vulva and perineum, 2 cm or less in greatest dimension, and with stromal invasion no greater than 1 mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 5 CNS Necrosis and Cystic Progression, CTCAE


Recurrent Digestive System Neuroendocrine Tumor G1

The reemergence of digestive system neuroendocrine tumor G1 after a period of remission.


Atrioventricular Block First Degree, CTCAE

A disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds.


Grade 2 Pleuritic Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 5 Bone Marrow Hypocellular, CTCAE

Death


Grade 3 Fetal Growth Retardation, CTCAE

<5% percentile of weight for gestational age


Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8

Stage IIB includes: T2, N0, M0. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Esophageal Neuroendocrine Tumor G1

A rare, well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The majority of cases have a polypoid appearance, are small lesions, and found incidentally.


Grade 3 Intraoperative Breast Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 4 Bronchopulmonary Hemorrhage NOS, CTCAE


Grade 4 Urethral Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Mediastinum Intra-Operative Injury, CTCAE


Transcription Factor-Associated Monogenic Diabetes

Monogenic diabetes caused by inactivating mutation(s) in transcription factors regulating expression of pancreatic beta cell genes.


Grade 3 Flashing Lights and Floaters in Vision, CTCAE


Vaginal intraepithelial neoplasia grade 2

Vaginal intraepithelial neoplasia characterized by the presence of nuclear intraepithelial neoplastic changes in the lower two-thirds of the epithelium and parakeratosis.


Respirable Crystalline Silica Exposure

Environmental, occupational or consumer-based exposure to respirable particles derived from industrial processing or breakdown of silica-containing materials such as sand, concrete, stone, mortar, bricks,  glass, pottery and ceramics.


Anemia due to Increased Destruction

Anemia that results from an increased rate of erythrocyte destruction.


Grade 4 Fetal Growth Retardation, CTCAE

<1% percentile of weight for gestational age


Grade 4 Adrenal Gland Intra-Operative Injury, CTCAE


Grade 2 Serum Amylase Increased, CTCAE

>1.5-2.0 x ULN; >2.0-5.0 x ULN and asymptomatic


Grade 3 Neonatal Sinus Tachycardia, AE

An adverse event in a newborn characterized by persistent sinus tachycardia; resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention).


Skin squamous cell carcinoma recurrent

The reemergence of squamous cell carcinoma of the skin after a period of remission.


Grade 2 Rectal Varices Hemorrhage, CTCAE


Recurrent Childhood Pilomyxoid Astrocytoma

The reemergence of pilomyxoid astrocytoma in childhood after a period of remission.


Grade 3 Esophageal Necrosis, CTCAE

Inability to aliment adequately by GI tract; invasive intervention indicated


Grade 1 Hyperparathyroidism, CTCAE

Mild symptoms; intervention not indicated


Grade 4 Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Testicular Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Stage IVA Cervical Cancer FIGO 2009

Cervical carcinoma with rectal or bladder involvement. (FIGO 2009)


Grade 5 Methemoglobinemia, CTCAE

Death


Human Papillomavirus-Related Malignant Neoplasm

A malignant neoplasm associated with the presence of human papillomavirus infection.


Grade 2 Amenorrhea, CTCAE

Present


Metaplastic carcinoma

A general term used to describe carcinomas arising from epithelial cells that have been transformed into another cells type (metaplastic epithelial cells). A representative example is the adenocarcinoma arising in Barrett esophagus. This term is also used to describe carcinomas in which the malignant epithelial cells show differentiation towards another cell type. A representative example of the latter is the metaplastic breast carcinoma in which the malignant glandular cells show squamous, spindle cell, or chondroid/osseous differentiation.


Foveolar-Type Adenoma

A rare neoplastic polyp that arises from the stomach.  It is characterized by the presence of foveolar-type epithelium.  It may be seen in patients with familial adenomatous polyposis.


Grade 4 Portal Hypertension, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Avascular joint necrosis

Death of bone tissue in a joint due to temporary or permanent interruption of blood flow.


Endogenous Infection

An infection caused by an infectious agent that is present on or in the host prior to the start of the infection.


Grade 3 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Unresectable Malignant Mesothelioma

Malignant mesothelioma that is not amenable to surgical resection.


Grade 5 Intraoperative Hemorrhage, CTCAE

Death


Classic Type Trichilemmoma

A benign epithelial tumor arising from the outer root sheath of hair follicles.


Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


Small Cell Adenocarcinoma

An adenocarcinoma composed of small malignant cells.


Pulmonary Edema, CTCAE

A disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure.


Grade 3 Productive Cough, CTCAE

Persistent or copious production of sputum; limiting self care ADL


Grade 1 Gait Disturbance, CTCAE

Mild change in gait (e.g., wide-based, limping or hobbling)


Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


Non-Congenital Amegakaryocytosis

An acquired non-neoplastic disorder characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Imperforate Vagina

A congenital birth defect characterized by the absence of a normal vaginal opening.


Grade 1 Brachial Plexus Intra-Operative Injury, CTCAE


Grade 3 Cranial Nerve X Neuropathy, CTCAE


Hoarseness, CTCAE

A disorder characterized by harsh and raspy voice arising from or spreading to the larynx.


Stage IIIC Uterine Corpus Cancer AJCC v7

Stage IIIC includes: IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  Endocervical glandular involvement only should be considered as Stage I and not as Stage II. T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Puncture wound

Disruption of tissue caused by a pointed object.


Grade 4 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Central Nervous System Erdheim-Chester Disease

Rare involvement of the central nervous system by Erdheim-Chester disease.


Grade 1 Glossopharyngeal Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Recurrent Laryngeal Nerve Injuries

Damage to the recurrent laryngeal nerve.


Pancreatic Duct Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the pancreatic duct.


Hepatobiliary Disorders - Other, Specify, CTCAE


Stage I Appendix Carcinoma AJCC v8

Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Kidney Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Skin Hypopigmentation, CTCAE

Hypopigmentation or depigmentation covering >10% BSA; associated psychosocial impact


Grade 1 Glomerular Filtration Rate, CTCAE


Malignant Vipoma

An aggressive neuroendocrine tumor located in the pancreas or small intestine. It is composed of cells containing vasoactive intestinal peptide.  It is associated with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria. It displays vascular invasion and metastasizes to other anatomic sites.


Squamoid Eccrine Ductal Carcinoma

A variant of ductal eccrine carcinoma with squamoid metaplasia.


Diffuse Pediatric-Type High Grade Glioma RTK1

An aggressive, WHO grade 4 diffuse glioma usually affecting children, adolescents, or young adults. It is characterized by receptor tyrosine kinase type 1 (RTK1) alterations.


Stage IVA Vulvar Cancer AJCC v7

Stage IVA includes: (T1/T2, N3, M0); (T3, Any N, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.  N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 2 Laryngeal Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 3 Aspiration, CTCAE

Dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally


Grade 5 Postoperative Hemorrhage, CTCAE

Death


Stenosis of Gastrointestinal Stoma, CTCAE

A finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body).


Grade 3 Genital Edema, CTCAE

Lymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL


Grade 5 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

Death


Refractory Primary Myelofibrosis

Primary myelofibrosis that is resistant to treatment.


Cecum Ulcer, CTCAE

Cecum Ulcer that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


Congenital absence of uterus

A congenital abnormality characterized by the complete absence of the uterus.


Vaso-Occlusive Crisis in Sickle Cell-Hemoglobin C Disease

Sickle cell-hemoglobin C disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.


Refractory Digestive System Carcinoma

A carcinoma hat arises from any part of the digestive system and is resistant to treatment.


Grade 4 Diarrhea, CTCAE

Life-threatening consequences; urgent intervention indicated


Myeloid Neoplasms with Germline RUNX1 Mutation

An autosomal dominant syndrome characterized by abnormalities in platelet number and function and enhanced risk of developing myelodysplastic syndrome/acute myeloid leukemia at a young age. Patients have germline monoallelic mutations in RUNX1 gene. The clinical presentation is variable, even within the same family. Most affected individuals have a mild to moderate bleeding tendency. Platelet counts are normal or mildly reduced, with normal platelet morphology and variable degrees of platelet dysfunction. Distinct families with germline RUNX1 mutations exhibit varying risks of development of myeloid neoplasms with 11-100% (median: 44%) of family members affected. (WHO 2017)


Parietal cell carcinoma

An adenocarcinoma of the stomach arising from the parietal cells. It is characterized by the presence of malignant cells with eosinophilic, finely granular cytoplasm.


Grade 5 Hypokalemia, CTCAE

Death


Ischemic Change

Cellular damage due to diminished oxygen supply to the tissues. The changes may be mild and associated with chronic inflammation, or severe and associated with ulceration, necrosis, and hemorrhage.


Grade 5 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Duodenal Obstruction, CTCAE

Symptomatic; altered GI function


Excessive Bruising

Bruising that is disproportionately high to the amount of trauma received or reported.


Grade 5 Leukocytosis, CTCAE

Death


Grade 3 Device Related Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IV includes: IVA: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Refractory Childhood Central Nervous System Neoplasm

A central nervous system neoplasm in childhood that is resistant to treatment.


Pancreatobiliary-type carcinoma

An invasive adenocarcinoma that arises from the ampulla of Vater. It is characterized by the presence of malignant cells that resemble the malignant cells of the pancreatic ductal or extrahepatic bile duct carcinomas.


Bile Duct Mucinous Cystic Neoplasm, High Grade

A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of severe atypia.


Grade 1 Dizziness, CTCAE

Mild unsteadiness or sensation of movement


Grade 3 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


hepatoid adenocarcinoma of gallbladder

A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate that resembles hepatocellular carcinoma.


Salivary Duct Inflammation, CTCAE

A disorder characterized by inflammation of the salivary duct.


Elevated bilirubin levels in the blood of a newborn infant. It is a normal response due to the limited ability to excrete bilirubin until the maturation of the neonatal liver is complete.


Grade 2 Other Metabolic and Laboratory, CTCAE


Grade 2 Ligament Intra-Operative Injury, CTCAE


Abnormal Blood Protein

One or more of the blood protein levels being higher or lower than normal (e.g. Albumin, C-reactive Protein).


Grade 4 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Clinical Stage II Esophageal Adenocarcinoma AJCC v8

Stage II includes: IIA: T1, N1, M0; IIB: T2, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Ventilation or Perfusion Signs and Symptoms


Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Gastrointestinal Stoma Leak, CTCAE


Grade 2 Small Intestine Ulcer, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Grade 3 Lower Gastrointestinal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 3 Pneumonitis and Pulmonary Infiltrates, CTCAE


Neuroendocrine Carcinoma of Unknown Primary

A neuroendocrine carcinoma that has metastasized from an  unknown primary site.


Preinvasive Neoplasm of the Ampullary Region

A premalignant neoplastic and dysplastic lesion that arises from the ampulla of Vater.  It is characterized by the absence of invasion.  This category includes intestinal-type adenomas, noninvasive papillary neoplasms of pancreatobiliary type, and flat intraepithelial neoplasia.


Anal Canal Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IA Esophageal Cancer AJCC v7

Stage IA includes: For squamous cell carcinoma: T1, N0, M0, G1, GX, Tumor location: Any. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  For adenocarcinoma: T1, N0, M0, G1-2, X. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated. GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Metastatic Digestive System Neuroendocrine Carcinoma

A neuroendocrine carcinoma that arises from any part of the digestive system and has metastasized to another anatomic site.


Grade 2 Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Penile Pain, CTCAE

Severe pain; limiting self care ADL


undifferentiated carcinoma of appendix

A high grade carcinoma arising from the appendix, characterized by the absence of glandular or squamous differentiation.


Grade 5 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Aortic Valve Disease, CTCAE

Death


Grade 1 Cranial Nerve XI Neuropathy, CTCAE


Childhood Esophageal Carcinoma

A rare carcinoma of the esophagus that occurs during childhood.


Grade 2 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

Death


Grade 1 Fever, CTCAE

38.0-39.0 degrees C (100.4-102.2 degrees F)


Distal Urethral Carcinoma

A carcinoma that arises from the distal part of the urethra.


Grade 1 Pharyngeal Stenosis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Tuberculosis of adrenal glands

Tuberculosis of the adrenal gland.


Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 5 Ileus, CTCAE

Death


Grade 3 Small Bowel NOS Intra-Operative Injury, CTCAE


Grade 4 Right Ventricular Dysfunction, CTCAE

Life-threatening consequences; urgent intervention indicated (e.g., ventricular assist device); heart transplant indicated


Grade 4 Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Testicular Sex Cord-Gonadal Stromal Tumor, Mixed Forms

A sex cord-stromal tumor of the testis which may contain any combination of cell types, for example Sertoli cells, Leydig cells, and granulosa cells. Symptoms include testicular swelling and gynecomastia.


Lugano Classification Stage II Bulky Adult Lymphoma AJCC v8

Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Grade 2 CD4 Lymphocytes Decreased, CTCAE

<500-200/mm3; <0.5-0.2 x 10e9/L


Grade 5 Lower Extremity Artery Injury, CTCAE


Grade 5 Ileal Stenosis, CTCAE

Death


Grade 5 Enterovesical Fistula, CTCAE

Death


Digestive System Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant large cells.


Grade 3 Flu Like Symptoms, CTCAE

Severe symptoms; limiting self care ADL


Clinical Stage IV Cutaneous Melanoma AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Evidence of distant metastasis. (AJCC 8th ed.)


Grade 2 Muscle Weakness Left-Sided, CTCAE

Symptomatic; evident on physical exam; limiting instrumental ADL


Gastrointestinal Carcinoid Tumor

A well differentiated neuroendocrine neoplasm of low grade arising from the digestive system. It is composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with small vesicular nuclei. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The tumor can occur anywhere in the digestive system; approximately 90% arise in the appendix.


Grade 4 Chylous Ascites, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Refractory Esophageal Adenocarcinoma

Esophageal adenocarcinoma that is resistant to treatment.


Small Bowel Stricture or Stenosis NOS, CTCAE


Stage II Adult Diffuse Mixed Cell Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Neonatal Pneumothorax, AE

An adverse event in a newborn characterized by a collection of air or other gas between the visceral and parietal pleura.


Grade 3 Upper Airway Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Chemical Gastritis

Gastritis caused by injury to the gastric mucosa by chemicals. The injury occurs due to reflux of bile and pancreatic enzymes.


Upper Extremity Soft Tissue Necrosis, CTCAE


Grade 1 Ileus, CTCAE

Asymptomatic and radiologic observations only


Grade 2 Middle Ear Intra-Operative Injury, CTCAE


Grade 2 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 4 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Nasopharynx Intra-Operative Injury, CTCAE


Diffuse malignant lymphoma - centroblastic-centrocytic


Stage IIB Gastric Cancer AJCC v7

Stage IIB includes: (T4a, N0, M0); (T3, N1, M0); (T2, N2, M0); (T1, N3, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Atrophic arthritis

An antiquated term indicating arthritis and bone loss.


Grade 2 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Intraoperative Ocular Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 5 Neonatal Sinus Tachycardia, AE

A sinus tachycardia adverse event in a newborn which results in death.


Grade 5 Small Bowel Obstruction NOS, CTCAE


Grade 4 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Grade 4 Pancreas Intra-Operative Injury, CTCAE


Grade 1 Arachnoiditis, CTCAE

Mild symptoms


Grade 4 Small Intestinal Obstruction, CTCAE


Grade 5 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Anal Mucositis, CTCAE

Severe symptoms; limiting self care ADL


small cell carcinoma of appendix

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the wall of the appendix. It is characterized by the presence of malignant small cells.


Adverse Event Associated with the Musculoskeletal System and Soft Tissue


Acute and chronic inflammation

The coexistence of a chronic inflammatory process with a superimposed polymorphonuclear neutrophilic infiltration.


Grade 2 Neuroendocrine Gonadotropin Secretion Abnormality, CTCAE


Childhood Pre-B Acute Lymphoblastic Leukemia

Pre-B acute lymphoblastic leukemia that occurs during childhood.


Grade 4 Epistaxis, CTCAE

Life-threatening consequences; urgent intervention indicated


In situ follicular neoplasia

A follicular neoplasia confined to the germinal centers of the lymph nodes, without evidence of disseminated disease. It is characterized by the replacement of a germinal center by neoplastic centrocytes with uniformly intense positivity for BCL2. The surrounding mantle cuff and lymphoid architecture are intact. It has a low rate of progression to follicular lymphoma, but is often associated with prior or synchronous overt lymphoma.


Benign Familial Infantile Seizures

A genetically heterogenous afebrile seizure disorder of infancy, typically occurring between the third and eight month of life, that is characterized by brief partial seizures occurring in clusters over a day or several days. Psychomotor and neurologic development before and after seizures are normal.


Grade 4 Local Complication of Device and Prosthesis, CTCAE


Refractory Anal Canal Squamous Cell Carcinoma

Anal canal squamous cell carcinoma that is resistant to treatment.


Chronic candidiasis

Candidiasis that is persistent or long-standing in nature.


Grade 1 Retroperitoneum Hemorrhage, CTCAE


Clear cell adenocarcinoma of lung

A well differentiated morphologic variant of lung adenocarcinoma characterized by the predominance of clear cells.


Grade 1 Flushing, CTCAE

Asymptomatic; clinical or diagnostic observations only


Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Benign Germinative Follicular Epithelium Neoplasm

A benign neoplasm involving the germinative follicular epithelium.


Grade 3 Wrist Fracture, CTCAE

Limiting self care ADL; elective operative intervention indicated requiring hospitalization


Benign neoplasm of extrahepatic bile ducts

A non-metastasizing neoplasm that arises from the extrahepatic bile ducts.


Localized Gastroesophageal Junction Adenocarcinoma

An adenocarcinoma that arises from the gastroesophageal junction and has not spread to other anatomic sites.


Cervical Non-Neoplastic Disorder

A non-neoplastic disorder that affects the cervix. Representative examples include endometriosis and cervicitis.


Malignant Lymphoma, Non-Cleaved Cell Type


Stage II Vulvar Cancer AJCC v7

Stage II includes: T2, N0, M0.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Carcinoma Arising in Bladder Diverticulum

A carcinoma arising in a bladder diverticulum. Approximately one-third to half of the cases represent non-invasive, low-grade or high-grade urothelial carcinomas. Approximately half of the invasive carcinomas are urothelial. The rest include adenocarcinomas, squamous cell carcinomas, and small cell carcinomas.


Grade 2 Nail Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 3 Blood Bilirubin Increased, CTCAE

>3.0-10.0 x ULN if baseline was normal; >3.0-10.0 x baseline if baseline was abnormal


Grade 5 Gallbladder Infection, CTCAE

Death


Grade 5 Typhlitis, CTCAE

Death


Grade 1 Diffuse Follicular Lymphoma

A follicular lymphoma with diffuse pattern characterized by the presence of 5 or less centroblasts per 40 high-power fields.


Stage IV Low Grade Adult Non-Hodgkin's Lymphoma


Unresectable Osteosarcoma

An osteosarcoma which is not amenable to surgical resection.


Device Complication

Any problem arising from the use of a medical device.


Infusion Site Extravasation, CTCAE

A disorder characterized by leakage of the infusion into the surrounding tissue. Signs and symptoms may include induration, erythema, swelling, burning sensation and marked discomfort at the infusion site.


Grade 3 Purpura, CTCAE

Combined area of lesions covering >30% BSA; spontaneous bleeding


Decreased Concomitant Drug AUC

Decreased area under the plot of plasma concentration of a concomitant drug against time after its administration.


Giant cell and spindle cell carcinoma

A malignant epithelial neoplasm composed of giant, pleomorphic cells and spindle cells.


Neonatal Edema, AE

An adverse event in a newborn characterized by accumulation of an excessive amount of fluid in cells or intercellular tissues.


Grade 1 Oculomotor Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Hookworm Infections

An infection that is caused by hookworms.


Gallbladder Benign Non-Epithelial Neoplasm

A non-metastasizing neoplasm arising from the gallbladder wall.  The neoplastic process does not involve the epithelial layer. Representative examples include leiomyoma, lipoma, and neurofibroma.


Borderline Fallopian Tube Endometrioid Tumor

A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by the presence of glandular or cystic spaces which contain atypical glandular epithelial cells resembling endometrial cells.  There is no evidence of stromal invasion.


Grade 1 Anal Sphincter Intra-Operative Injury, CTCAE


Non-T Non-B CALLA Positive Adult Acute Lymphoblastic Leukemia

A non-T, non-B, acute lymphoblastic leukemia in which the lymphoblasts are positive for the common acute lymphoblastic leukemia antigen (CALLA) occurring in adults.


Pathologic Stage IIA Merkel Cell Carcinoma AJCC v8

Stage IIA includes: T2-3, N0, M0. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Grade 5 Colonic Ulcer, CTCAE

Death


Grade 4 Peritoneal Necrosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Non-Neoplastic Corneal Disorder

A non-neoplastic disorder that affects the cornea.


Hodgkin's disease mixed cellularity stage I site unspecified

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Grade 2 Folliculitis, CTCAE

Covering 10-30% of the body surface area; topical intervention initiated


Vulvar Warty Carcinoma

A squamous cell carcinoma that arises from the vulva and is characterized by the presence of a warty surface and cellular changes that are caused by human papillomavirus infection.


Appendix Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

A well differentiated neuroendocrine tumor arising from the wall of the appendix.  It is characterized by the presence of neoplastic cells forming round solid nests and occasionally glandular structures.  The majority of the cases are asymptomatic, and they are found incidentally in appendectomy specimens.  The majority of the tumors are located in the distal end of the appendix and they are enterochromaffin-cell carcinoid tumors producing serotonin.  Most cases show morphologic evidence of appendiceal wall and lymphatic vessel invasion by tumor cells.  Despite the morphologic evidence of invasion, appendiceal carcinoid tumors only infrequently produce lymph node or distant metastases.


Solid Neoplasm

A benign or malignant neoplasm arising from tissues that do not include fluid areas.  Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma).  Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors.


Grade 3 Large Intestinal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Laboratory Test Result

The outcome of a laboratory test.


Grade 3 Other Dermatology or Skin, CTCAE


Intimal dissection

A dissection of an artery that occurs though a tear in the inner lining of the blood vessel.


Grade 3 Laryngospasm, CTCAE

Recurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage)


Advanced Pancreatobiliary Carcinoma

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Uterine Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Stenosis of Gastrointestinal Stoma, CTCAE

Symptomatic; IV fluids indicated <24 hrs; manual dilation at bedside


Gallbladder Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of the contents of the gallbladder.


Needle injury

A penetrating stab wound from a needle (or other sharp object) that may result in exposure to blood or other body fluids.


Urethra Obstruction, CTCAE

Blockage of the normal flow of urine in the urethra occurring following a procedure or pharmaceutical intervention.


Tissue Kallikrein Deficiency

A disorder characterized by the partial or complete absence of tissue-type kallikrein activity in the tissues and glandular secretions where it is normally present.


Cutaneous Melanoma by AJCC v6 Stage

A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v6 classification system.


Alpha trait thalassemia

A condition in which a person has reduced protein production from two of the four alpha-globin alleles.


Fatigue, CTCAE 5.0

A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities.


Grade 5 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Lower Extremity Artery Intra-Operative Injury, CTCAE


Glandular Cell Intraepithelial Neoplasia


Lymphedema, CTCAE

A disorder characterized by excessive fluid collection in tissues that causes swelling.


Virus-Related Lymphoma

Lymphoma that is caused by a virus infection.


Grade 2 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Intraoperative Respiratory Injury, CTCAE

Death


Grade 1 Watering Eyes, CTCAE

Intervention not indicated


Grade 5 Psychosis, CTCAE

Death


Throat and Pharynx and Larynx Pain, CTCAE


Atypical hyperplasia of breast

A general term that refers to atypical hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and columnar cell hyperplasia with atypia.


Grade 5 Rash Acneiform, CTCAE

Death


Grade 3 Spleen Intra-Operative Injury, CTCAE


Endocrine mucin-producing sweat gland carcinoma

A rare, low-grade sweat gland carcinoma with neuroendocrine differentiation. It usually arises on the eyelids and periorbital skin. It affects mostly older individuals. Women are affected more frequently than men. Morphologically, it is characterized by well-demarcated nodules with cystic, papillary, or cribriform architectural patterns. The neoplastic cells are small to intermediate polygonal to round cells. Small amounts of intracellular or extracellular mucin are present. In some cases, this carcinoma is a precursor of mucinous carcinoma.


Refractory Non-Cutaneous Melanoma

Non-cutaneous melanoma that is resistant to treatment.


benign fibrous histiocytoma of bone

A rare, benign neoplasm, usually arising from the non-metaphyseal regions of long bones or pelvis.  It is characterized by the presence of fibroblastic spindle cells arranged in a whorled storiform pattern, osteoclast-like giant cells, foam cells, inflammatory cells, hemosiderin deposition and stromal hemorrhage.


Grade 4 Small Intestine Infection, CTCAE


Musculoskeletal Chest Pain due to Intercostal Myofascial Injury

A condition in which there is musculoskeletal chest pain secondary to trauma to the connective tissues between the ribs. (ACC/AHA)


Adrenal Gland Intra-Operative Injury, CTCAE


Grade 4 Throat and Pharynx and Larynx Pain, CTCAE


Female sexual arousal disorder

A disorder characterized by a recurrent or persistent inability to attain or maintain until completion of sexual activity an adequate physical response of sexual excitement, consisting of vasocongestion in the pelvis, vaginal lubrication and expansion, and swelling of the external genitalia.


Grade 5 Biliary Tree Stricture or Stenosis, CTCAE


Grade 3 Ventricular Arrhythmia NOS, CTCAE


Spinal Injury Related to Birth

An injury to the spine sustained during the birthing process.


Grade 2 Central Nervous System Hemorrhage, CTCAE


Stage IVB Vaginal Cancer AJCC v6 and v7

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Spinal Cord Infarct During Birth

Ischemic necrosis of the spinal cord due to spinal artery occlusion during the birthing process.


Grade 3 Thrush, CTCAE

IV antifungal intervention indicated


Recurrent Childhood Gemistocytic Astrocytoma

The reemergence of gemistocytic astrocytoma in childhood after a period of remission.


Grade 3 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Meningioma

A meningioma that has spread from its original site of growth to another anatomic site.


Grade 3 Endocrine Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Residual schizophrenia

A subtype of schizophrenia in which the individual has suffered an episode of schizophrenia but there are no longer any delusions, hallucinations, disorganized speech or behavior. Residual symptoms are seen in the form of negative symptoms (such as flat affect or avolition) or attenuated positive symptoms (such as odd beliefs).


Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Decreased Time To Concomitant Drug Peak Blood Concentration

Decreased time following concomitant drug administration at which the peak drug blood concentration occurs.


Panniculitis, Peritoneal

A disorder characterized by chronic inflammation and fibrosis of the adipose tissues in the peritoneal cavity.


Stage III Ampulla of Vater Cancer AJCC v7

Stage III includes: T4, Any N, M0. T4: Tumor invades peripancreatic soft tissues or other adjacent organs or structures other than the pancreas.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 3 Platelet Count Decreased, CTCAE

<50,000-25,000/mm3; <50.0-25.0 x 10e9/L


Oral Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips.


Chemical conjunctivitis

Inflammation of the conjunctiva in a newborn due to chemical irritation which was acquired postnatally from iatrogenic causes.


Pancreatic Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the pancreas. The Ki-67 index is higher than 20%.


Polygenic Obesity

Obesity associated with variations in multiple genes.


Grade 3 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Biliary Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Port Site Infection

An infection at an anatomic location used for vascular access.


Sunstroke

A reaction to prolonged exposure to high temperatures that can result in a failure of the body's temperature control system. It is often characterized by body temperature over 105 degrees, dehydration, headache, dizziness, nausea, vomiting, and muscle weakness.


Grade 2 Psychosis Including Hallucinations and Delusions, CTCAE


Acute Radiation Skin Toxicity

Erythema, desquamation, and other cutaneous injury resulting from, and occurring within days or weeks of, radiation exposure.


Stage III Appendix Neuroendocrine Tumor AJCC v7

Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor directly invades other adjacent organs or structures, e.g., abdominal wall and skeletal muscle.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Delusions, CTCAE

A disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense.


Nail Discoloration, CTCAE

A disorder characterized by a change in the color of the nail plate.


Chronic Myelomonocytic Leukemia-2

A chronic myelomonocytic leukemia characterized by the presence of 10-19 percent blasts in the bone marrow and 5-19 percent blasts in the peripheral blood or by the presence of Auer rods regardless of the blasts count.


Grade 3 Spermatic Cord Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 1 Partial Thromboplastin Time, CTCAE


Grade 4 Conjunctiva Intra-Operative Injury, CTCAE


Grade 5 Death NOS, CTCAE

Death


Grade 5 Pancreatic Anastomotic Leak, CTCAE

Death


Grade 4 Neonatal Diarrhea, AE

A diarrhea adverse event in a newborn characterized by life-threatening consequences (e.g. severe dehydration).


Birth Complication

The development of a problematic medical situation that occurs concurrently with the birth of a neonate.


Grade 2 Diffuse Follicular Lymphoma

A follicular lymphoma with diffuse pattern characterized by the presence of 6-15 centroblasts per 40 high-power fields.


Ann Arbor Stage II AIDS-Related Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 3 Thrombosis or Thrombus or Embolism, CTCAE


Grade 3 Bladder Intra-Operative Injury, CTCAE


Unresectable Neuroendocrine Neoplasm

A neuroendocrine neoplasm that is not amenable to surgical resection.


Dissociative Hysteria

A disorder characterized by sudden, unexpected travel away from one's home or place of work accompanied by an inability to recall one's past; the individual is confused about his or her personal identity and may assume a new identity.


Stage IIA Bone Cancer AJCC v8

Stage IIA includes: T1, N0, M0, G2 or G3. T1: Tumor measuring 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Grade 4 CD4 Lymphocytes Decreased, CTCAE

<50/mm3; <0.05 x 10e9/L


Proximal Gastric Adenocarcinoma

A gastric adenocarcinoma that arises from the proximal part of the stomach.


Grade 4 Abdomen NOS Intra-Operative Injury, CTCAE


Grade 4 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Bone Marrow Hypocellular, CTCAE

Moderately hypocellular or >25-<50% reduction from normal cellularity for age


Fallopian Tube Cancer by AJCC v6 Stage

A term that refers to the staging of fallopian tube carcinoma according to the American Joint Committee on Cancer, 6th edition.


Fistula of gallbladder

An abnormal communication between the gallbladder and another organ or cavity.


Aorticopulmonary Septal Defect

A congenital heart malformation characterised by incomplete separation of the truncus arteriosus and the aorticopulmonary trunk, resulting in communication between the aorta and pulmonary trunk.


Grade 3 Rectal Obstruction, CTCAE

Hospitalization indicated; invasive intervention indicated; limiting self care ADL


Grade 3 Bronchial Fistula, CTCAE

Invasive intervention indicated


Grade 2 Bronchospasm and Wheezing, CTCAE


Grade 2 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Grade 3 Chylous Ascites, CTCAE

Severe symptoms; elective operative intervention indicated


Grade 3 Partial Thromboplastin Time, CTCAE


Eruption cyst of jaw

A variant of dentigerous cyst found in the soft tissues overlying an erupting tooth. (WHO 2017)


Grade 2 Gastric Perforation, CTCAE

Invasive intervention not indicated


High Grade Gastric Intraepithelial Neoplasia

A gastric intraepithelial lesion characterized by the presence of neoplastic cells that are cuboidal with a high nucleus to cytoplasmic ratio, prominent nucleoli, significant architectural changes, and increased number of mitotic figures.


Grade 5 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Retinopathy, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Localized Edema, CTCAE

A disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site.


Grade 3 Ovarian Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 5 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acral Edema

Accumulation of an excessive amount of watery fluid in cells or intercellular tissues of the hands and feet.


Early Inflammatory Arthritis

Early stages of inflammatory arthritis, when the underlying diagnosis is uncertain, usually little or no joint damage has occurred. Treatment may alter the disease course (e.g., potentially avert progression to full RA or other diagnosis).


FIGO Grade 3 Endometrial Mucinous Adenocarcinoma

A primary mucinous adenocarcinoma of the endometrium that contains more than 50% non-squamous solid areas.


Adult Acute Myeloid Leukemia with Minimal Differentiation

An acute myeloid leukemia with minimal differentiation occurring in adults.


Bladder granuloma

A granuloma that develops in the urinary bladder.


Adverse Event Attributed to Research

An indication that an adverse event is causally related to processes a subject was exposed to during a research study.


Non-Neoplastic Respiratory System Disorder

A non-neoplastic disorder that affects the respiratory system.  Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, tracheitis, and tracheal agenesis.


Grade 1 Lipohypertrophy, CTCAE

Asymptomatic and covering <10% BSA


Slipped Capital Femoral Epiphysis, CTCAE


Prostate Ductal Adenocarcinoma, Cribriform Pattern

A prostate ductal adenocarcinoma characterized by the presence of neoplastic large back-to-back glands with slit-like lumens.


Increased Drug Half Life

Increased period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.


Grade 3 Oral Intra-Operative Injury, CTCAE


Grade 5 Diarrhea, CTCAE

Death


Adult Pineocytoma

A pineocytoma occurring in adults.


Recurrent Neoplastic Post-Transplant Lymphoproliferative Disorder

The reemergence of neoplastic post-transplant lymphoproliferative disorder after a period of remission.


Grade 5 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Incised wound

A wound or cleft resulted from tissue separation into parts or laid open or penetrated with a sharp edge or instrument.


Grade 4 Gallbladder Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Hemorrhoids, CTCAE 5.0

A disorder characterized by the presence of dilated veins in the rectum and surrounding area.


Unresectable Fallopian Tube High Grade Serous Adenocarcinoma

Fallopian tube high-grade serous adenocarcinoma that is not amenable to surgical resection.


Laryngeal Edema, CTCAE

A disorder characterized by swelling due to an excessive accumulation of fluid in the larynx.


Grade 2 Slipped Capital Femoral Epiphysis, CTCAE


An epithelioid hemangioendothelioma that is not amenable to surgical resection.


Fallopian Tube Cancer by AJCC v8 Stage

A term that refers to the staging of fallopian tube cancer according to the American Joint Committee on Cancer, 8th edition.


Grade 1 Intraoperative Hepatobiliary Injury, CTCAE

Primary repair of injured organ/structure indicated


Grade 5 Hallucinations, CTCAE

Death


Adenocarcinoma with spindle cell metaplasia

An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to spindle-shaped cells.


Grade 5 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Phrenic Nerve Dysfunction, CTCAE


Grade 3 Colitis, CTCAE

Severe abdominal pain; peritoneal signs


Bronchus Obstruction and Stenosis, CTCAE


Grade 5 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Periodontal Disease, CTCAE

Moderate gingival recession or gingivitis; multiple sites of bleeding on probing; moderate bone loss


Unresectable Cervical Carcinoma

Cervical carcinoma that is not amenable to surgical resection.


Grade 4 Endophthalmitis, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Grade 2 Somnolence and Depressed Level of Consciousness, CTCAE


Small Bowel Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Squamous cell carcinoma in situ with questionable stromal invasion

A malignant epithelial neoplasm involving all the layers of the squamous epithelium, but it is not certain if it is confined to the squamous epithelium or it has invaded the basement membrane and the underlying stroma.


Stage II Uterine Corpus Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Adverse Event Associated with Cardiac Arrhythmia


Cancer-related Cognitive Dysfunction

The effects of cancer and its treatments on cognitive processes.


Grade 5 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Gastrointestinal Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 4 Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


Prostate cancer stage D

Metastatic disease.


Polyp of esophagus

A benign intraluminal polypoid neoplasm of the esophagus.  It includes the squamous papilloma and the giant fibrovascular polyp.


Grade 4 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


caprolactams

A lactam in which the amide bond is contained within a seven-membered ring, which includes the amide nitrogen and the carbonyl carbon.


An  alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum.


Isoxazole

A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of  isoxazoles.


nutrient

A nutrient is a food component that an organism uses to survive and grow.


enzyme inhibitor

A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.


Oxazole

A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.


Dihydroconiferyl alcohol

A member of class of phenols that is 2-methoxyphenol substituted by a 3-hydroxypropyl group at position 4.


benzimidazole

A mancude organic heterobicyclic parent that is a heterocyclic organic compound comprising fused benzene and imidazole rings.


Benzoxazole

A benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5.


long-chain primary fatty alcohol

A long-chain fatty alcohol in which the hydroxy group is attached to a methylene (CH2) group.


(R)-cyclopentolate

The (R)-enantiomer of cyclopentolate.


(S)-cyclopentolate

The (S)-enantiomer of cyclopentolate.


Eckol

A phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity.


tetramine

Any polyamine that contains four amino groups.


nucleobase analogue

A molecule that can substitute for a normal nucleobase in nucleic acids.


alpha-L-fructofuranose

A L-fructofuranose with an alpha-configuration at the anomeric position.


beta-L-fructofuranose

A L-fructofuranose with a beta-configuration at the anomeric position.


L-fructofuranose

The L-enantiomer of fructofuranose.


beta-L-fructopyranose

A L-fructopyranose with a beta-configuration at the anomeric position.


L-fructopyranose

The L-enantiomer of fructopyranose.


L-cysteine thioether

Any L-cysteine derivative obtained by conversion of the thiol group into a sulfide.


D-(+)-Maltose

A glycosylglucose consisting of two D-glucopyranose units connected by an alpha-(1->4)-linkage.


Lactobiose

A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.


D-Glucose

A glucopyranose having D-configuration.


D-glucose

A glucose with D-configuration.


quinone

Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).


Menaquinone 10

Any member of the class of menaquinones that is 2-methyl-1,4-naphthoquinone with an unsaturated isoprenoid chain at the 3-position.


Vitamin K

Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.


A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.


hydroxyanthraquinones

An anthraquinone substituted with one or more hydroxy groups.


prenylquinone

A quinone substituted by a polyprenyl-derived side-chain. Prenylquinones occur in all living cells. Due to their amphiphilic character, they are mainly located in biological membranes where they function as electron and proton carriers in the photosynthetic and respiratory electron transport chains. Some prenylquinones also perform more specialised roles sucy as antioxidants and enzyme cofactors. Prenylquinones are classified according to ring structure: the main classes are menaquinones, phylloquinones, ubiquinones and plastoquinones.


Any member of the class of benzoquinones that is 1,4-benzoquinone or its C-substituted derivatives.


acenoquinone

Quinones containing an acene fused ring system.


Any benzoquinone derived from 2,3-dimethoxy-5-methylbenzoquinone; one of a group of naturally occurring homologues. The redox-active quinoid moiety usually carries a polyprenoid side chain at position 6, the number of isoprenoid units in which is species-specific. Ubiquinones are involved in the control of mitochondrial electron transport, and are also potent anti-oxidants.


menaquinones

Any prenylnaphthoquinone having a prenyl or polyprenyl group at position 3 and a methyl group at position 2 on the naphthoquinone ring.


prenylnaphthoquinone

Any napthoquinone that is substituted at position 2 by a prenyl or polyprenyl group. The term also includes compounds that are functionalised on the prenyl or polyprenyl chain (e.g. by a hydroxy group).


An aminoglycoside antibiotic that is (1S,3S)-3,5,12-trihydroxy-3-(1-hydroxyethyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene having a 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl residue attached at position 1 via a glycosidic linkage.


p-quinones

A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring.


A polycyclic aromatic ketone metabolite of naphthalene.


A naphthoquinone in which the oxo groups of the quinone moiety are at positions 1 and 4 of the parent naphthalene ring.


benzoquinones

Any quinone resulting from the formal oxidation of catechol, hydroquinone, or their C-substituted derivatives.


hydroxyquinone

Any quinone in which one or more of the carbons making up the quinone moiety is substituted by a hydroxy group.


N-acetylglucosamine

An N-acylglucosamine where the N-acyl group is specified as acetyl.


enol ether

Ethers ROR' where R has a double bond adjacent to the oxygen of the ether linkage.


(R)-Bifonazole

A 1-[biphenyl-4-yl(phenyl)methyl]imidazole that is the R-enantiomer of bifonazole.


A pyridinium ion obtained by protonation of the ring nitrogen of pyridoxal.


DL-Alanine

An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.


iodothyronine

An  iodoamino acid in which the amino acid specified is  thyronine.


organoiodine compound

An organoiodine compound is a compound containing at least one carbon-iodine bond.


iodoamino acid

An amino acid containing at least one iodo substituent.


benzyl alcohols

Compounds containing a phenylmethanol skeleton.


A 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol in which the carbon bearing the hydroxy group has R configuration while the remaining stereocentre has S configuration.


A secondary amino compound that is 4-(2-amino-1-hydroxypropyl)phenol in which one of the hydrogens attached to the nitrogen is replaced by a 2-(4-hydroxyphenyl)ethyl group.


Ent-butopamine

A 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol in which both stereocentres have S configuration.


A 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol in which the carbon bearing the hydroxy group has S configuration while the remaining stereocentre has R configuration.


Dioxinodehydroeckol

A phlorotannin that is [1,4]benzodioxino[2,3-a]oxanthrene substituted by hydroxy groups at positions 1, 3, 6, 9 and 11. Isolated from the brown alga Ecklonia stolonifera, it exhibits radical scavenging activity.


hemiaminal

Any organic amino compound that has an amino group and a hydroxy group attached to the same carbon atom. Hemiaminals are intermediates in the formation of imines by addition of an amine to an aldehyde or ketone; those derived from primary amines are particularly unstable.


A member of the class of quinolones that is 1,2,3,4-tetrahydroquinoline in which the hydrogens at positions 2 and 4 have been replaced by oxo groups.


Any hydroxyflavanone with a hydroxy substituent at position 3' of the phenyl ring.


hydroxyflavanone

A member of the class of flavanones that consists of flavanone with one or more hydroxy substituents.


Any  oxo steroid carrying the oxo group at position 17.


(R)-Ketamine

The R- (less active) enantiomer of ketamine.


cyclopentanones

Any alicyclic ketone that consists of a cyclopentane skeleton substituted by at least one oxo group.


cyclohexenones

Any six-membered alicyclic ketone having one double bond in the ring.


Any oxo steroid where an oxo substituent is located at position 3.


Any methoxyflavanone having a methoxy substituent located at position 4'.


cyclohexanones

Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.


flavanones

Members of the class of flavans with a 3,4-dihydro-2-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives.


Any 3-oxo steroid that contains a double bond between positions 1 and 2.


alicyclic ketone

A cyclic ketone in which the carbocyclic ring structure which may be saturated or unsaturated, but may not be a benzenoid or other aromatic system.


methoxyflavanone

A member of the class of flavanones that consists of flavanone with one or more methoxy substituents.


A 3-oxo steroid that has alpha configuration at position 5.


Any 3-oxo steroid that has beta- configuration at position 5.


A 3-oxo-Delta(1) steroid containing an additional double bond between positions 4 and 5.


A 3-oxo steroid conjugated to a C=C double bond at the alpha,beta position.


monomethoxyflavanone

Any methoxyflavanone that is flavanone substituted by a methoxy group.


dihydroxyflavanone

Any  hydroxyflavanone carrying two hydroxy substituents.


A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.


A dicarboximide that is 3,4,5,6-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a p-bromophenyl group.


enamide

An alpha,beta-unsaturated carboxylic acid amide of general formula R(1)R(2)C=CR(3)-C(=O)NR(4)R(5) in which the amide C=O function is conjugated to a C=C double bond at the alpha,beta position.


cinnamamides

An enamide which is cinnamamide or a derivative of cinnamamide obtained by replacement of one or more of its hydrogens.


acrylamides

An enamide which is acrylamide or a derivative of acrylamide obtained by replacement of one or more of its hydrogens.


(-)-Nomifensine

The S enantiomer of nomifensine.


methylbenzene

Any alkylbenzene that is benzene substituted with one or more methyl groups.


hemiacetal

A compound having the general formula RR'C(OH)OR'' (R'' =/= H).


lactol

Cyclic hemiacetals formed by intramolecular addition of a hydroxy group to an aldehydic or ketonic carbonyl group. They are thus 1-oxacycloalkan-2-ols or unsaturated analogues.


cyclic hemiketal

A hemiacetal  having the structure R2C(OH)OR (R =/= H), derived from a ketone by formal addition of an alcohol to the carbonyl group. The term 'cyclic hemiketals', once abandoned by IUPAC, has been reinstated as a subclass of hemiacetals.


beta-D-Fructopyranose

A D-fructopyranose in which the anomeric centre has beta-configuration.


hemiketal

A hemiacetal having the structure RR(1)C(OH)OR(2) (R, R(1), R(2) =/= H), derived from a ketone by formal addition of an alcohol to the carbonyl group.


chlorins

Dihydroporphyrin compounds where saturated carbon atoms are located at the nonfused carbon atoms of one of the pyrrole rings.


dihydroporphyrin

A porphyrin compound containing a porphyrin ring with one double bond fewer than in porphyrin itself.


pyridinecarboxamide

A member of the class of pyridines that is a substituted pyridine in which at least one of the substituents is a carboxamide or N-substituted caraboxamide group.


Tilidine, (-)-

An ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate that has R configuration at the carbon bearing the phenyl group and S configuration at the carbon bearing the dimethylamino group. It is the enantiomer of dextilidine; the opioid analgesic tilidine is the racemate comprising equimolar amounts of dextilidine and ent-dextilidine.


Dextilidine

An ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate that has S configuration at the carbon bearing the phenyl group and R configuration at the carbon bearing the dimethylamino group. The opioid analgesic tilidine is the racemate comprising equimolar amounts of dextilidine and its enantiomer, ent-dextilidine. A prodrug, tilidine is converted by the liver to the active analgesic, nortilidine; virtually all of the opioid activity resides in the (1S,2R) isomer (i.e. the isomer derived from dextilidine).


maleimides

Compounds containing a cyclic dicarboximide skeleton in which the two carboacyl groups on nitrogen together with the nitrogen itself form a 1H-pyrrole-2,5-dione structure.


2-furoate ester

Any carboxylic ester where the carboxylic acid component is 2-furoic acid.


tertiary carboxamide

A carboxamide resulting from the formal condensation of a carboxylic acid with a secondary amine; formula RC(=O)NHR(1)R(2).


4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.


A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted.


(S)-adrenaline

The S-enantiomer of adrenaline.


DL-Cysteine

A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.


hydroxy fatty acid

Any fatty acid carrying one or more hydroxy substituents.


hydroxybutyric acid

Any compound comprising a butyric acid core carrying at least one hydroxy substituent.


DL-Tryptophan

An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.


Phosphate ion

A phosphate ion that is the conjugate base of hydrogenphosphate.


aryl dialkyl phosphate

Any aryl phosphate having a single aryl substituent and two alkyl substituents.


purine arabinonucleoside monophosphate

A purine nucleoside monophosphate in which the sugar component is specified as arabinosyl.


adenyl nucleotide

A  nucleotide having adenine as the base.


nucleoside 5'-phosphate

A ribosyl or deoxyribosyl derivative of a pyrimidine or purine base in which C-5 of the ribose ring is mono-, di-, tri- or tetra-phosphorylated.


dl-O-Phosphoserine

A serine derivative that is serine substituted at the oxygen atom by a phosphono group.


nucleoside phosphate

A nucleobase-containing molecular entity that is a nucleoside in which one or more of the sugar hydroxy groups has been converted into a mono- or poly-phosphate. The term includes both nucleotides and non-nucleotide nucleoside phosphates.


inorganic phosphate salt

A phosphate salt that lacks C-H bonds


Thiamine diphosphate

A thiamine phosphate that is thiamine(1+) in which the hydroxy group has been replaced by a diphosphate group. It is the active form of vitamin B1 and an essential cofactor for enzymes in key metabolic pathways.


nucleotide

A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid.


phospho sugar

Any monosaccharide containing an alcoholic hydroxy group esterified with phosphoric acid.


Thiamine monophosphate

A thiamine phosphate that is thiamin(1+) in which the hydroxy group is replaced by a phosphate group.


phosphate monoester

An organic phosphate that is phosphoric acid in which one of the hydrogens is replaced by an organyl group.


Thiamine triphosphate

A thiamine phosphate that is thiamine(1+) in which the hydroxy group is replaced by a triphosphate group. It is found in low amounts in most vertebrate tissues and can phosphorylate certain proteins.


inorganic phosphate

Any  phosphate that contains no carbon atom.


pentose phosphate

Any phospho sugar that is the phosphate derivative of pentose.


phospholipid

A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides.


purine nucleotide

Any nucleotide that has a purine nucleobase.


Pyridoxine Hydrochloride

The hydrochloride salt of pyridoxine.


A member of the class of quinolones that is the amide obtained from formal condensation of the carboxy group of 1-allyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with the amino group of 2-amino-3-ethyl-1,3,4-thiadizole.


pyrazolone

A member of the class of pyrazoles in which one of the carbons of the pyrazole ring is substituted by an oxo group.


Efonidipine, (+)-

A 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate that has (S)-configuration. It is a blocker of L- and T-type Ca(2+) channels.


(S)-Ethosuximide

The (S)-enantiomer of ethosuximide.


Thiophene

Compounds containing at least one thiophene ring.


(R)-carbinoxamine

The (R)- (inactive) enantiomer of carbinoxamine.


ribonucleoside

Any nucleoside where the sugar component is D-ribose.


pyranone

Any of a class of cyclic chemical compounds that contain an unsaturated six-membered ring with one ring oxygen atom and an oxo substituent.


tetrahydrofuranone

Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.


methylpyridines

Any member of the class of pyridines that carries at least one methyl substituent.


A member of the class of indazoles that is 2H-indazole substituted by 4-(piperidin-3-yl)phenyl and aminocarbonyl groups at positions 2 and 7, respectively. It is a potent PARP1 inhibitor with IC50 of 3.2 nM.


pyrroline

Any organic heteromonocyclic compound with a structure based on a dihydropyrrole.


A secondary carboxamide resulting from the formal condensation of the carboxy group of 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid with the primary amino group of 5-(4-aminophenyl)-1,3,4-oxadiazole-2(3H)-thione.


pyrimidine 5'-deoxyribonucleoside

A pyrimidine deoxyribonucleoside that is a pyrimidine ribonucleoside in which the hydroxy group at the 5' position is replaced by a hydrogen.


Mefloquine

An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.


Thiamin acetic acid

A monocarboxylic acid that is thiamine(1+) which carries an oxo group at position 2.


A methyl phenyl(piperidin-2-yl)acetate that has R configuration alpha to the carbonyl group and S configuration at the stereocentre bearing the nitrogen.


Carboxy-ptio

A mmeber of the class of imidazolines and organic radical that is 4,4,5,5-tetramethyl-3-oxo-4,5-dihydro-1H-3lambda(5)-imidazol-1-yl]oxidanyl substituted at position 2 by a 4-carboxyphenyl group.


Tetrahydropyridine

Any of a class of heterocyclic amines having a saturated five-membered ring.


(R)-paliperidone

A 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one that is the (R)-enantiomer of paliperidone.


(-)-Thalidomide

A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has S-configuration at the chiral centre.


(S)-eperisone

A 1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one that has S configuration.


monohydroxypyridine

A hydroxypyridine carrying a single hydroxy substituent.


A pyridinium ion obtained by protonation of both nitrogens of pyridoxamine.


oxanes

Any organic heteromonocyclic compoundthat is oxane or its substituted derivatives.


oxolanes

Any oxacycle having an oxolane (tetrahydrofuran) skeleton.


Rotoxamine

The (S)- (active) enantiomer of carbinoxamine.


A C-nitro compound consisting of 2-nitroethene-1,1-diamine where one of the nitrogens bears ethyl and (6-chloro-3-pyridinyl)methyl while the other nitrogen carries a methyl group.


(S)-ranolazine

An N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide that is the (S)-enantiomer of ranolazine (the racemate is a drug used for treatment of chronic angina).


(S)-lipoic acid

The (S)-enantiomer of lipoic acid. Not found in nature, it may exert detrimental effects on biosystems.


(S)-Cycrimine

The (S)-enantiomer of cycrimine.


aminopyridine

Compounds containing a pyridine skeleton substituted by one or more amine groups.


(S)-paliperidone

A 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one that is the (S)-enantiomer of paliperidone.


Monophosphothiamine

An organic chloride salt of thiamine(1+) monophosphate.


piperidinemonocarboxylic acid

Any member of the class of piperidines in which one of the carbons of the piperidine ring is substituted by a carboxy group.


nucleoside

An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents.


(R)-Eperisone

A 1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one that has R configuration.


cyanopyridine

Any pyridine carrying at least one cyano substituent.


Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.


adenosines

Any purine ribonucleoside that is a derivative of adenosine.


The (R)-(+)-enantiomer of bupivacaine.


pyrimidine deoxyribonucleoside

A deoxyribonucleoside containing a pyrimidine base.


Xeplion

A 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate that is the (R)-enantiomer of paliperidone palmitate.


(S)-doxapram

The (S)-enantiomer of doxapram.


The piperidinecarboxamide obtained by the formal condensation of N-propylpipecolic acid and 2,6-dimethylaniline.


diazoline

A five-membered organic heteromonocyclic compound containing two nitrogen atoms and a double bond.


purine ribonucleoside

A ribonucleoside that has a purine moiety as the nucleobase (the R group in the illustration).


R-Toloxatone

The (R)-enantiomer of toloxatone.


A member of the class of furans that in which the furan ring is substituted by a (2-amino-4-oxo-1,3-thiazol-5(4H)-ylidene)methyl group at position 2 and a 4,5-dimethyl-2-nitrophenyl group at position 5, and i which the amino substituent of the thiazolone has been substituted by a 3-carboxy-4-chlorophenyl group. It is a direct activator of the alpha-subunit of AMP-activated protein kinase (5' adenosine monophosphate-activated protein kinase, AMPK).


(r)-Omeprazole

A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has R configuration at the sulfur atom.


Efonidipine, (-)-

A 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate that has (R)-configuration. It is a selective blocker of T-type Ca(2+) channels.


aminopyrimidine

A member of the class of  pyrimidines that is pyrimidine substituted by at least one amino group and its derivatives.


Streptonigrin

Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.


pyrimidone

A pyrimidine carrying one or more oxo substituents.


pyrimidines

Any compound having a pyrimidine as part of its structure.


Thiazole

An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom.


(S)-paliperidone palmitate

A 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate that is the (S)-enantiomer of paliperidone palmitate.


Imidazoline

An imidazoline compound having the double bond at the 2-position.


purine 2'-deoxyribonucleoside

A 2'-deoxyribonucleoside that has a purine moiety as the nucleobase (the R group in the illustration).


Any pyridone that is pyridin-4-one or its derivatives by substitution of one of more of the hydrogens.


nitrofuran antibiotic

A member of the class of furans in which the furan ring is substituted by a nitro group and which also has significant antibiotic properties.


pyrimidine antifungal agent

A member of the class of pyrimidines that has significant antifungal properties.


Lipoic acid

The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.


hydroxypyridone antifungal drug

Any pyridone which is substituted on the nitrogen by a hydroxy group and which has been used as an antifungal drug.


Pyridoxamine hydrochloride

A hydrochloride obtained by combining pyridoxamine with one molar equivalent of hydrochloric acid. Used for treatment of diabetic nephropathy.


A methyl phenyl(piperidin-2-yl)acetate in which both stereocentres have S configuration. It is the inactive enantiomer in the racemic drug methylphenidate.


Fominoben

Any compound containing morpholine as part of its structure.


1,2,5-Thiadiazole substituted at the 3 position by a 3-(tert-butylamino)-2-hydroxypropoxy group and at the 4 position by a morpholin-4-yl group. The (S)-(-) enantiomer, also known as timolol, is a beta-adrenergic antagonist and is used in the mangement of glaucoma, hypertension, angina pectoris and myocardial infarction, and for the prevention of migraine.


(R)-chlormezanone

The (R)-enantiomer of chlormezanone.


chloropyridine

Compounds containing a pyridine nucleus substituted with one or more chlorine atoms.


pyridinemonocarboxylic acid

A monocarboxylic acid in which the carboxy group is attached to a pyridine (or substituted pyridine) ring.


(S)-Iclaprim

A 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine in which the chiral centre has S configuration.


furans

Compounds containing at least one furan ring.


Pyridoxal hydrochloride

A hydrochloride obtained by combining pyridoxal with one molar equivalent of hydrochloric acid.


Thiamine(1+) aldehyde

A heteroarenecarbaldehyde that is thiamine(1+) in which the 2-hydroxyethyl group has been replaced by a 2-oxoethyl group.


(R)-doxapram

The (R)-enantiomer of doxapram.


hydroxymethylpyridine

Any member of the class of  pyridines carrying a hydroxymethyl substituent at unspecified position.


(R)-Ethosuximide

The (R)-enantiomer of ethosuximide.


purine deoxyribonucleoside

A deoxyribonucleoside containing a purine base.


Thiamine hydrochloride dihydrate

A hydrate that is the dihydrate form of thiamine hydrochloride.


hydroxypyridine

Any member of the class of pyridines with at least one hydroxy substituent.


Thiamine Hydrochloride

A hydrochloride obtained by combining thiamine chloride with one molar equivalent of hydrochloric acid.


dihydrofuran

Compounds containing a mono-unsaturated furan ring skeleton.


A pyrrolidinone in which the oxo group is at position 2 of the pyrrolidine ring.


(R)-Zopiclone

The (5R)-enantiomer of zopiclone.


S-Toloxatone

The (S)-enantiomer of toloxatone.


(R)-ranolazine

An N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide that is the (R)-enantiomer of ranolazine (the racemate is a drug used for treatment of chronic angina).


A methyl phenyl(piperidin-2-yl)acetate that has S configuration alpha to the carbonyl group and R configuration at the stereocentre bearing the nitrogen.


Proline

An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.


purines D-ribonucleoside

A purine ribonucleoside that is a purine derivative attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage.


4-Pyridoxic acid

A methylpyridine that is 2-methylpyridine substituted by a hydroxy group at C-3, a carboxy group at C-4, and a hydroxymethyl group at C-5. It is the catabolic product of vitamin B6 and is excreted in the urine.