Stage III Soft Tissue Sarcoma AJCC v7

Stage III includes: (T2a, T2b, N0, M0, G3); (Any T, N1, M0, Any G).  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  G3: Grade 3.  There is no T2a for the pathologic group. (AJCC 7th ed.)


Fibrous tissue neoplasm of skin

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A neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts.


Vulvar Angiomyxoma

A deep or superficial angiomyxoma of the vulva.  It may recur following resection.


Stage II Soft Tissue Sarcoma AJCC v7

Stage II includes: IIA (T1a, N0, M0, G2, G3); (T1b, N0, M0, G2, G3); IIB (T2a, N0, M0, G2); (T2b, N0, M0, G2).  T1a: Superficial tumor 5 cm or less in greatest dimension.  T1b: Deep tumor 5 cm or less in greatest dimension.  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G2: Grade 2.  G3: Grade 3. (AJCC 7th ed.)


Biphenotypic sinonasal sarcoma

A rare, slow-growing, low-grade soft tissue sarcoma arising from the sinonasal tract. It presents with non-specific obstructive nasal symptoms. Morphologically, it is an infiltrative, cellular spindle cell neoplasm. It is associated with rearrangement of the PAX3 gene.


Breast Inflammatory Myofibroblastic Tumor

A multinodular intermediate fibroblastic neoplasm arising from the breast.  It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells.


Bladder Benign PEComa

A benign perivascular epithelioid cell tumor arising from the bladder.


Recurrent Malignant Soft Tissue Neoplasm

Reemergence of a malignant soft tissue neoplasm after a period of remission.


Sinonasal Undifferentiated Pleomorphic Sarcoma

An undifferentiated pleomorphic sarcoma that arises from the nasal cavity and paranasal sinuses.


Locally Advanced Soft Tissue Sarcoma

Soft tissue sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Digestive System Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the digestive system.


Digestive System Lipoma

A lipoma arising from an anatomic site in the digestive system.


Prostate Solitary Fibrous Tumor

A rare solitary fibrous tumor that arises from the prostate gland.


Stage I Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage I includes: T1, N0, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


AIDS-Related Gastric Kaposi Sarcoma

A Kaposi sarcoma arising from the stomach in patients who are infected with the human immunodeficiency virus.


Vulvar Kaposi Sarcoma

A Kaposi sarcoma arising from the vulva.


Digestive System Leiomyoma

A leiomyoma arising from an anatomic site in the digestive system.


Clear-Cell Myomelanocytic Tumors

A very rare, usually benign neoplasm with perivascular epithelioid cell differentiation characterized by the presence of clear spindle cells arranged in fascicles and nests that usually affects young girls.  Patients usually present with a painful abdominal mass.


Vaginal Superficial Myofibroblastoma

An uncommon, benign, well circumscribed mesenchymal neoplasm that grows beneath the vaginal epithelium. It is characterized by the presence of cells containing bland ovoid, spindle, or stellate-shaped nuclei in a collagenous stroma.


Uterine Corpus Epithelioid Smooth Muscle Tumor of Uncertain Malignant Potential

A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and is composed of neoplastic epithelioid cells.


Vaginal Undifferentiated Sarcoma

A high grade infiltrating sarcoma that arises from the vagina. It is characterized by the presence of malignant small spindle cells with scant cytoplasm.


Prostate Soft Tissue Neoplasm

A mesenchymal neoplasm that arises from the prostate gland.


Stage I Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

Stage I includes: T1 or T2, N0, M0, Low Mitotic Rate. T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Childhood Soft Tissue Sarcoma

Soft tissue sarcoma occurring in childhood.


Atypical Lipomatous Tumor/Well Differentiated Liposarcoma of Deep Soft Tissue

An atypical lipomatous tumor/well differentiated liposarcoma that occurs in deep soft tissue.


Stage I Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

Stage I includes: IA: (T1 or T2, N0, M0, Low Mitotic Rate); IB: (T3, N0, M0, Low Mitotic Rate). T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. T3: Tumor measuring more than 5 cm but not more than 10 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Sinonasal Sarcoma

A sarcoma that arises from the nasal cavity and paranasal sinuses.


Seminal Vesicle Schwannoma

A schwannoma that affects the seminal vesicle.


Vulvar Smooth Muscle Tumor of Uncertain Malignant Potential

A smooth muscle neoplasm that arises from the vulva and cannot be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings.


Transplant-Related Kaposi Sarcoma

A Kaposi sarcoma that arises in a patient with a history of organ transplantation.


Esophageal Fibroma

A benign neoplasm arising from the fibrous soft tissue of the esophagus. It is characterized by the presence of spindle-shaped fibroblasts.


Conjunctival Stromal Tumor

A rare benign stromal tumor that arises from the bulbar conjunctiva. It is characterized by the presence of myxoid/collagenous stroma, spindle-shaped cells, pseudonuclear inclusions, and multinucleated cells.


Recurrent Uterine Corpus Sarcoma

The reemergence of uterine corpus sarcoma after a period of remission.


Kaposi's sarcoma, metastatic

Kaposi sarcoma that has spread from its original site of growth to another anatomic site.


Sinonasal Leiomyoma

A leiomyoma that arises from the nasal cavity and paranasal sinuses.


Advanced Soft Tissue Sarcoma

A sarcoma of soft tissue that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IV Gastric Gastrointestinal Stromal Tumor

Stage IV includes: (Any T, N1, M0, Mitotic rate: Any rate); (Any T, Any N, M1, Mitotic rate: Any rate). N1: Regional lymph node metastasis. M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Peritoneal Calcifying Fibrous Tumor

A benign well-circumscribed lesion arising from the mesentery. It is characterized by the presence of fibroblasts, lymphoplasmacytic infiltrates, collagenous stroma formation, psammoma bodies, and dystrophic calcifications.


Advanced Epithelioid Sarcoma

Epithelioid sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Soft Tissue Angiosarcoma

An angiosarcoma that arises from the soft tissues, usually in the deep muscles of the lower extremities, retroperitoneum, mediastinum, and mesentery.


Oral Cavity Soft Tissue Sarcoma

A soft tissue sarcoma that arises from the oral cavity.


Scrotal Sarcoma

A sarcoma involving the scrotum.


Recurrent Extraskeletal Myxoid Chondrosarcoma

Reemergence of extraskeletal myxoid chondrosarcoma after a period of remission


Malignant Epithelioid Cell Type Gastrointestinal Stromal Tumor

An epithelioid cell type gastrointestinal stromal tumor with an aggressive clinical course.


Kidney Angiosarcoma

A rare angiosarcoma arising from the kidney.


Skin Fibrous Histiocytoma, Histiocytic Variant

A morphologic variant of fibrous histiocytoma of the skin. It is characterized by the presence of xanthomatous fibrohistiocytic cells, giant cells, and hemosiderin deposition.


Desmoplastic fibroma

A rare, benign, locally aggressive osteolytic neoplasm. It is characterized by the presence of a rich collagenous stroma and spindle cells with minimal cellular atypia.


Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential

A smooth muscle neoplasm that arises from the uterine corpus and cannot be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings.


Broad ligament leiomyoma

A leiomyoma that arises from the broad ligament.


Stage IIIB Gastric Gastrointestinal Stromal Tumor

Stage IIIB includes: T4, N0, M0, Mitotic rate: High. T4: Tumor more than 10 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Benign Skin Fibroblastic Neoplasm

A benign neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts without malignant characteristics.


Locally Advanced Undifferentiated Pleomorphic Sarcoma

An undifferentiated pleomorphic sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Desmoplastic Small Round Cell Tumor

Desmoplastic small round cell tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Paratesticular Liposarcoma

A liposarcoma that arises from the paratesticular region.


Vulvar Lipoblastoma-Like Tumor

A benign, well-defined, lobulated, myxoid or gelatinous tumor that arises from the vulva. It shares morphological features with lipoblastoma, myxoid liposarcoma, and spindle cell lipoma. It is characterized by a lobulated growth and is composed of mature adipocytes, lipoblasts, and spindle cells without atypia in a myxoid matrix. DDIT3 and PLAG1 gene rearrangements seen in lipoblastoma and myxoid liposarcoma are not present in this tumor. It can recur infrequently and there are no reports of metastasis.


Recurrent Soft Tissue Sarcoma

The reemergence of soft tissue sarcoma after a period of remission.


Uterine Corpus Endometrial Stromal and Related Neoplasms

A category of benign or malignant mesenchymal neoplasms that arises from the uterine corpus. This category includes the endometrial stromal nodule which is benign and non-invasive, the endometrial stromal sarcoma, and the undifferentiated uterine sarcoma. The endometrial stromal sarcoma is an invasive malignant neoplasm, further subdivided into low grade and high grade endometrial stromal sarcoma. Undifferentiated uterine sarcoma was previously also known as high grade endometrial stromal sarcoma. In 2014, high grade endometrial stromal sarcoma was reclassified and is currently considered a distinct and rare neoplasm. It appears to have a prognosis that falls between low grade endometrial stromal sarcoma and undifferentiated sarcoma.


Uterine Corpus Tumor Resembling Ovarian Sex Cord Tumor

A usually benign neoplasm that arises from the uterine corpus. It resembles ovarian sex cord tumors. It lacks a component of recognizable endometrial stroma and the JAZF1-SUZ12 fusion which is characteristic of the endometrial stromal neoplasms.


Central Nervous System Dedifferentiated Solitary Fibrous Tumor

A central nervous system solitary fibrous tumor characterized by the presence of areas of abrupt transition to high grade sarcoma.


Breast Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the breast.


Vulvar Deep (Aggressive) Angiomyxoma

A locally infiltrating, non-metastasizing vulvar angiomyxoma.  It may recur following resection.


Peritoneal Low Grade Endometrioid Stromal Sarcoma

A very rare sarcoma that arises from the peritoneum and is characterized by the presence of cells that resemble endometrial stromal cells.


Stage IIIC Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Unresectable Epithelioid Sarcoma

Epithelioid sarcoma that is not amenable to surgical resection.


Oral Cavity Soft Tissue Neoplasm

A soft tissue neoplasm that arises from the oral cavity.


Adult Desmoplastic Small Round Cell Tumor

A desmoplastic small round cell tumor occurring in adults.


Major Salivary Gland Sarcoma

A rare malignant soft tissue neoplasm that arises from the parotid gland, submandibular gland, or sublingual gland.  Representative examples include fibrosarcoma, angiosarcoma, leiomyosarcoma, and Kaposi sarcoma.


Recurrent Kaposi Sarcoma

The reemergence of Kaposi sarcoma after a period of remission.


adult extraskeletal myxoid chondrosarcoma

An extraskeletal myxoid chondrosarcoma occurring in adults.


Peripheral Intraneural Angiosarcoma

A malignant vascular neoplasm arising from the peripheral nerves.


Endemic African Kaposi Sarcoma

A Kaposi sarcoma that occurs in adults and children in Equatorial Africa.


Stage IIB Uterine Sarcoma AJCC v7

Tumor involves other pelvic tissues.  No regional lymph node or distant metastasis.


Intermediate Fibrohistiocytic Neoplasm

A fibrohistiocytic neoplasm usually affecting younger patients.  It is characterized by an increased risk of local recurrence and a low risk of metastasis.


Stage IB Soft Tissue Sarcoma AJCC v7

Stage IB includes: (T2a, N0, M0, G1, GX); (T2b, N0, M0, G1, GX).  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Grade 1.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Vulvar Cellular Angiofibroma

A benign neoplasm arising from the fibrous tissue of the vulva. It is characterized by the presence of spindle-shaped fibroblasts, numerous dilated vascular channels, and increased cellularity.


Sinonasal Hemangioma

A hemangioma that arises from the nasal cavity and paranasal sinuses.


Benign Epithelioid Cell Type Gastrointestinal Stromal Tumor

An epithelioid cell type gastrointestinal stromal tumor with an indolent clinical course.


Benign Extraskeletal Cartilaginous and Osseous Neoplasm

A benign mesenchymal neoplasm with cartilaginous or osseous differentiation arising from the soft tissues exclusively.  Representative examples include chondroma and osteoma.


Low Grade Endometrial Stromal Sarcoma

An infiltrating mesenchymal tumor arising from the uterine corpus, cervix, vagina, and the ovary. It is characterized by the presence of oval to spindle-shape cells that resemble the cells of the endometrial stroma, without evidence of significant atypia and pleomorphism. Numerous small vessels are also present. It is usually characterized by indolent growth and late recurrences.


Vulvar Epithelioid Sarcoma

An epithelioid sarcoma that arises from the vulva.


Central Nervous System Solitary Fibrous Tumor, Grade 2

A solitary fibrous tumor that arises from the central nervous system. It corresponds to the more cellular, less collagenous tumor with plump cells and staghorn vasculature which was diagnosed as central nervous system hemangiopericytoma in the past.


High Grade Paranasal Sinus Sarcoma

An aggressive malignant soft tissue neoplasm that arises from the paranasal sinus.  It is characterized by the presence of high-grade histologic features.


Locally Advanced Unresectable Soft Tissue Sarcoma

A soft tissue sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Virus-Related Sarcoma

A sarcoma that is caused by a virus.


Visceral Angiosarcoma

A soft tissue angiosarcoma arising from the internal organs.


Stage IA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8

Stage IA includes: T1, N0, M0, G1, GX. T1: Tumor measuring 5 cm or less in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Total differentiation, mitotic count and necrosis score of 2 or 3. (AJCC 8th ed.)


Soft Tissue Sarcoma by AJCC v8 Stage

A term that refers to the staging of soft tissue sarcoma, following the rules of the TNM AJCC v8 classification system.


Angiofibroma of Soft Tissue

A benign fibroblastic neoplasm composed of uniform spindle cells with abundant fibromyxoid stroma and a prominent network of innumerable branching, thin-walled blood vessels. It typically arises in the extremities, mainly the legs, frequently involving or adjacent to large joints such as the knee. Unusual anatomical locations include the back, abdominal wall, pelvic cavity, and breast. The tumors are often subcutaneous but may be intramuscular and deep. The lesion presents most often as a slow-growing painless mass. (WHO 2020)


Thyroid Gland Malignant Peripheral Nerve Sheath Tumor

A rare malignant peripheral nerve sheath tumor that arises from the thyroid gland.


Conjunctival Sarcoma

A sarcoma that arises from the conjunctiva.


Osteosarcoma that arises from the soft tissue and is confined to a specific site without evidence of spread to other anatomic sites.


Laryngeal Soft Tissue Neoplasm

A soft tissue neoplasm that arises from the larynx.


Skin Pleomorphic Lipoma

A pleomorphic lipoma arising from the skin.


Kidney Leiomyoma

A benign smooth muscle neoplasm arising from the kidney.


Uterine Corpus Low Grade Endometrial Stromal Sarcoma

A rare, indolent, invasive mesenchymal tumor that arises from the endometrial stroma. It is characterized by the presence of a plexiform vasculature, infrequent mitoses, and insignificant cytologic atypia. Late recurrences may occur.


Malignant fibrous histiocytoma metastatic

An undifferentiated pleomorphic sarcoma that has spread to other anatomic sites.


Bone Leiomyoma

A rare leiomyoma affecting the bone.


Skin Soft Tissue Neoplasm

A mesenchymal neoplasm that arises from the skin.


Ectopic hamartomatous thymoma

A benign, well-circumscribed tumor of the neck occurring in adults.  It is characterized by the presence of spindle cells, epithelial islands, and adipose tissue.  There is no evidence of thymic origin or differentiation, despite the use of the term thymoma in the literature.


Mammary-Type Myofibroblastoma

A benign mesenchymal neoplasm characterized by the presence of spindle shaped myofibroblasts and mast cells in a collagenous stroma.  It is histologically identical to the myofibroblastoma of breast.  It usually arises from the subcutaneous tissue and the most common sites of involvement are the inguinal/groin, paratesticular, and vulvovaginal areas.


Dermal Fibroma

A benign neoplasm arising from the dermis. It is characterized by the presence of spindle-shaped fibroblasts.


Periosteal fibroma

A benign fibrous neoplasm arising from the periosteal connective tissue that surrounds a bone.


Metastatic Soft Tissue Sarcoma

Soft tissue sarcoma that has spread from the original site of growth to another anatomic site.


Stage I Soft Tissue Sarcoma AJCC v7

Stage I includes: IA (T1a, N0, M0, G1, GX); (T1b, N0, M0, G1, GX); IB (T2a, N0, M0, G1, GX); (T2b, N0, M0, G1, GX).  T1a: Superficial tumor 5 cm or less in greatest dimension.  T1b: Deep tumor 5 cm or less in greatest dimension.  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Grade 1.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Sinonasal glomangiopericytoma

A sinonasal soft tissue neoplasm with hemangiopericytoma-like features.


Stage III Adult Soft Tissue Sarcoma AJCC v7


Stage IIIA Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

Stage IIIA includes: T3, N0, M0, High Mitotic Rate. T3: Tumor measuring more than 5 cm but not more than 10 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Stage IIIA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Low Grade Paranasal Sinus Sarcoma

A malignant soft tissue neoplasm that arises from the paranasal sinus.  It is characterized by the presence of low-grade histologic features.


Locally Advanced Epithelioid Sarcoma

Epithelioid sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Hemangioma, Cavernous, Central Nervous System

A cavernous hemangioma arising from the central nervous system.


Vaginal Soft Tissue Neoplasm

A benign or malignant mesenchymal neoplasm that arises from the vagina.  Representative examples include leiomyoma, rhabdomyoma, leiomyosarcoma, endometrioid stromal sarcoma, and botryoid-type embryonal rhabdomyosarcoma.


Unresectable Desmoid Fibromatosis

Desmoid fibromatosis that is not amenable to surgical resection.


Parotid Gland Liposarcoma

A liposarcoma that arises from the parotid gland.


Laryngeal Soft Tissue Sarcoma

A sarcoma that arises from soft tissue of the larynx.


Adult Soft Tissue Sarcoma

Soft tissue sarcoma occurring in adults.


Benign Uterine Corpus PEComa

A benign neoplasm with perivascular epithelioid cell differentiation arising from the uterine corpus. It is characterized by the absence of pleomorphism and scarcity or absence of mitotic figures. It usually affects perimenopausal women. Patients present with a pelvic mass or abnormal bleeding.


Stage IA Adult Soft Tissue Sarcoma AJCC v7


Refractory Malignant Myoepithelioma

A malignant myoepithelioma that does not respond to treatment.


Hemosiderotic Fibrolipomatous Tumor

A non-encapsulated, slow-growing, locally aggressive subcutaneous tumor characterized by the presence of adipocytes, hemosiderin-laden spindle cells, hemosiderin-laden macrophages, osteoclast-like giant cells, and scattered chronic inflammatory cells. It usually arises from the dorsum of the foot, ankle, dorsum of the hand, thigh, calf, or cheek.  It may recur if it is not completely excised but does not metastasize.


Central Nervous System Undifferentiated Pleomorphic Sarcoma

A rare undifferentiated pleomorphic sarcoma (formerly known as malignant fibrous histiocytoma) involving the central nervous system.


Uterine Corpus Myxoid Smooth Muscle Tumor of Uncertain Malignant Potential

A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and displays myxoid changes.


Tumor of Specialized Prostatic Stroma

A rare neoplasm arising from specialized prostatic stroma.  This category includes prostatic stromal proliferations of uncertain malignant potential and prostatic stromal sarcomas.


Paratesticular Soft Tissue Neoplasm

A mesenchymal neoplasm that arises from the paratesticular region.


Vulvar Distal-Type Epithelioid Sarcoma

A rare epithelioid sarcoma of the distal type that arises from the vulva.


Non-Metastatic Childhood Soft Tissue Sarcoma

A soft tissue sarcoma that occurs during childhood and is confined to a specific site without evidence of spread to other anatomic sites.


A morphologic variant of dermatofibrosarcoma protuberans characterized by the presence of a fibrosarcomatous component.


Vaginal Solitary Fibrous Tumor

A rare solitary fibrous tumor that arises from the vagina.


Stage IV Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

Stage IV includes: (Any T, N1, M0, Any Mitotic Rate); (Any T, Any N, M1, Any Mitotic Rate). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Seminal Vesicle Leiomyoma

A leiomyoma that arises from the seminal vesicle.


EBV-Positive Inflammatory Follicular Dendritic Cell Sarcoma

A  follicular dendritic cell sarcoma that occurs almost exclusively in the liver and spleen and is consistently associated with Epstein-Barr virus.


Childhood Undifferentiated Pleomorphic Sarcoma

An undifferentiated pleomorphic sarcoma that occurs during childhood.


Stage IVB Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Superficial Atypical Lipomatous Tumor/Well Differentiated Liposarcoma

An atypical lipomatous tumor/well differentiated liposarcoma that occurs in a superficial body structure.


Solitary Adult Fibroma

A solitary benign neoplasm arising from the fibrous soft tissues. The tumor is characterized by the presence of spindle-shaped fibroblasts.


Vaginal Smooth Muscle Tumor of Uncertain Malignant Potential

A smooth muscle neoplasm that arises from the vagina and cannot be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings.


Gastric Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor that arises from the stomach.  It covers a spectrum of benign to malignant soft tissue neoplasms and includes most gastric smooth muscle tumors, leiomyoblastomas, and tumors formerly called gastrointestinal autonomic nerve tumors.


Plexiform fibrohistiocytic tumor

An intermediate fibrohistiocytic neoplasm of the skin that usually affects children and young adults. It is a multinodular, poorly circumscribed tumor characterized by the presence of multinucleated giant cells, mononuclear histiocyte-like cells, and spindle fibroblast-like cells arranged in a plexiform pattern.


Subcutaneous Nodular Fasciitis

A self-limiting, rapidly growing, non-encapsulated benign neoplasm arising from the subcutaneous tissues. It is characterized by the growth of plump spindle-shaped fibroblasts in a storiform pattern, multinucleated osteoclast-like giant cells, red blood cell extravasation, chronic inflammatory cells, and high mitotic activity.


Uterine Corpus Endometrial Stromal Sarcoma by AJCC v8 Stage

A term that refers to the staging of uterine corpus endometrial stroma sarcoma according to the American Joint Committee on Cancer, 8th edition.


Superficial CD34-Positive Fibroblastic Tumor

A low-grade neoplasm arising from the skin and subcutis. It is characterized by the presence of spindled cells with abundant, eosinophilic, granular to glassy cytoplasm, low mitotic activity, marked nuclear pleomorphism, diffuse CD34 expression, and frequent keratin immunoreactivity. The prognosis is excellent.


Skin Spindle Cell Lipoma

A spindle cell lipoma arising from the skin.


Cervical Soft Tissue Neoplasm

A benign or malignant mesenchymal neoplasm of the cervix.  Representative examples include rhabdomyoma, alveolar soft part sarcoma, and AIDS-related Kaposi sarcoma.


Extragastrointestinal Gastrointestinal Stromal Tumor

A rare gastrointestinal stromal tumor that presents as a solitary mass outside the gastrointestinal tract.


Stage IIB Soft Tissue Sarcoma AJCC v7

Stage IIB includes: (T2a, N0, M0, G2); (T2b, N0, M0, G2).  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G2: Grade 2.  (AJCC 7th ed.)


Cervical Angiosarcoma

A highly aggressive malignant vascular neoplasm that arises from the cervix and shows endothelial cell differentiation.


Lipoma of appendix

A benign adipose tissue neoplasm involving the wall of the appendix.


Sinonasal Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that arises from the nasal cavity and paranasal sinuses.


Omentum Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor that arises from the omentum. This is an extragastrointestinal tumor, meaning that it does not arise directly from the gastrointestinal tract.


Dermatofibrosarcoma Protuberans with Giant Cell Fibroblastoma-Like Differentiation

A morphologic variant of dermatofibrosarcoma protuberans characterized by areas of fibroblastoma like-differentiation, and the presence of giant cells.


Vulvar Fibrolipoma

A lipoma of the vulva with a predominant fibrous component.


Skin Angiolipoma

An angiolipoma arising from the skin.


Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8

Stage IV includes: (Any T, N1, M0, Any G); (Any T, Any N, M1, Any G). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Uterine Corpus Sarcoma by AJCC v7 Stage

A term that refers to the staging of uterine corpus sarcoma, following the rules of the TNM AJCC v7 classification system.


Parotid Gland Sarcoma

A sarcoma that arises from the parotid gland.


Recurrent Soft Tissue Sarcoma of the Trunk and Extremities

The reemergence of a soft tissue sarcoma of the trunk and extremities after a period of remission.


Gastric Plexiform Fibromyxoma

A rare soft tissue neoplasm arising from the stomach.  It occurs in the antrum and pyloric region and it may extend into the duodenum.  It occurs in all ages and affects men and women equally.  Morphologically it is characterized by a multinodular plexiform mass that involves the muscular layer.  The neoplastic cells are spindle-shaped and the mitotic activity is low.  It follows a benign clinical course.


Sinonasal Angiosarcoma

An angiosarcoma that arises from the nasal cavity and paranasal sinuses.


Breast Vascular Neoplasm

A benign or malignant vascular neoplasm that arises from the breast.


Extraskeletal Cartilaginous and Osseous Neoplasm

A benign or malignant mesenchymal neoplasm with cartilaginous or osseous differentiation arising from the soft tissues exclusively.  Representative examples include chondroma, osteoma, and osteosarcoma.


Skin Fibrous Histiocytoma, Cellular Variant

A morphologic variant of fibrous histiocytoma of the skin. It is characterized by the presence of spindle-shaped fibrohistiocytic cells and increased cellularity.


Extraskeletal osteosarcoma metastatic

A soft tissue osteosarcoma which has spread to another anatomical site.


Paratesticular Hemangioma

A capillary or cavernous hemangioma that arises from the paratesticular region.


Paratesticular Leiomyoma

A leiomyoma that arises from the paratesticular region.


Uterine Ligament Leiomyoma

A leiomyoma that arises from the broad or other uterine ligaments.


Perivascular epithelioid tumor, malignant

A usually large and aggressive tumor with perivascular epithelioid cell differentiation characterized by the presence of marked nuclear atypia, pleomorphism, increased mitotic activity, necrosis, and infiltrative margins.  The most common metastatic sites are liver, lungs, lymph nodes, and bone.


Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor by AJCC v8 Stage

A term that refers to the staging of small intestinal, esophageal, colorectal, mesenteric, and peritoneal gastrointestinal stromal tumor (GIST), following the rules of the TNM AJCC v8 classification system. (from AJCC 8th Ed.)


Stage IIIB Uterine Sarcoma AJCC v7

Stage IIIB includes: T3b, N0, M0. T3b: Tumor infiltrates abdominal tissues, more than one side.  N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


Kaposi's sarcoma of extrahepatic bile duct

A Kaposi sarcoma that arises from the extrahepatic bile ducts.


Benign Oral Cavity Soft Tissue Neoplasm

A non-metastasizing soft tissue neoplasm that arises from the oral cavity.


Dedifferentiated Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor that through the process of dedifferentiation, results in an uncommon phenotype. Dedifferentiation in the context of GIST, may manifest as loss of CD117 expression and regression from specialized tissue to a more anaplastic/pleomorphic appearance, high nuclear atypia, high mitotic activity, and necrosis.


sarcoma of tongue

A sarcoma that arises from the tongue.


Stage IC Uterine Sarcoma AJCC v7

Stage IC includes: T1c, N0, M0.  T1c: For adenosarcoma: tumor invades more than half of the myometrium.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  Stage IC does not apply for leiomyosarcoma and endometrial stromal sarcoma.  (AJCC 7th ed.)


Abdominal Undifferentiated Pleomorphic Sarcoma

Undifferentiated pleomorphic sarcoma involving the organs and structures in the abdomen.


Ectomesenchymal Chondromyxoid Tumor

A rare, well circumscribed, non-encapsulated tumor that arises in the oral cavity, most often the anterior tongue.  It is characterized by the presence of round to spindle cells in a chondromyxoid or hyalinized stroma.  Recurrences have been observed in a minority of patients.


Tongue Liposarcoma

A liposarcoma that arises from the tongue.


Gastric Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the stomach.


Kidney Epithelioid Angiomyolipoma

A rare variant of kidney angiomyolipoma that consists of at least 80% epithelioid cells. (WHO 2016)


Benign Fibroblastic Neoplasm

A benign mesenchymal neoplasm characterized by the presence of neoplastic fibroblasts without malignant characteristics.


Bladder Angiosarcoma

A very rare angiosarcoma that arises from the bladder.


Primitive non-neural granular cell tumor

A rare, low-grade skin neoplasm of mesenchymal cells of unknown lineage with prominent cytoplasmic granularity. The lesions are most commonly non-ulcerated papules or nodules. Most cases are indolent, despite worrisome histopathologic features. Few cases with regional lymph node metastasis have been reported. (WHO 2018)


Stage IV Uterine Sarcoma AJCC v7

Stage IV includes: IVA (T4, Any N, M0); IVB (Any T, Any N, M1).  T4: Tumor involves bladder or rectum.  M0: No distant metastasis.  M1: Distal metastasis (excluding adnexa, pelvic and abdominal tissues).  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


Prostate Granular Cell Tumor

A rare granular cell tumor that arises from the prostate gland.


Stage IV adult soft tissue sarcoma

A sarcoma that arises from the soft tissues during adulthood and has spread from the original site of growth to another anatomic site.


Malignant Extraskeletal Cartilaginous and Osseous Neoplasm

A malignant mesenchymal neoplasm with cartilaginous or osseous differentiation arising from the soft tissues exclusively. Extraskeletal osteosarcoma is a representative example.


Stage IVB Uterine Sarcoma AJCC v7

Stage IVB includes: Any T, Any N, M1.  M1: Distal metastasis (excluding adnexa, pelvic and abdominal tissues).  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


Spindle Cell Type Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor composed of neoplastic spindle cells.


Central Nervous System Epithelioid Hemangioendothelioma

A low-grade malignant blood vessel neoplasm that arises from the central nervous system.  It is characterized by the presence of epithelioid endothelial cells.


Stage IIA Uterine Sarcoma AJCC v7

Tumor involves adnexa.  No regional lymph node or distant metastasis.


Soft Tissue Sarcoma of the Trunk and Extremities by AJCC v8 Stage

A term that refers to the staging of soft tissue sarcoma of the trunk and extremities, following the rules of the TNM AJCC v8 classification system.


Extra-abdominal fibromatosis

An insidious poorly circumscribed neoplasm arising from the soft tissues outside the abdomen. It is characterized by the presence of elongated spindle-shaped fibroblasts, vascular collagenous stroma formation, and an infiltrative growth pattern.


Epithelioid sarcoma metastatic

An epithelioid sarcoma which has spread to another anatomic site.


Scrotal Liposarcoma

A liposarcoma involving the scrotum.


Vulvar Lipoma

An uncommon benign neoplasm of the vulva, composed of lobules of mature adipocytes.


Stage II Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage II includes: T2, N0, M0. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Childhood Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor (GIST) occurring in childhood. Pediatric GISTs differ biologically from adult GISTs in that only 11% of pediatric GISTs have activating mutations of KIT and PDGFRA.


Vaginal Angiomyofibroblastoma

An angiomyofibroblastoma arising from the vagina.


Uterine Corpus Metastasizing Leiomyoma

A cytologically benign smooth muscle neoplasm that arises from the uterine corpus and has metastasized to the lungs, abdomen, or lymph nodes. It usually presents in women with a history of benign uterine leiomyomas that have been surgically removed years before the extrauterine neoplasm spread.


Atypical fibroxanthoma - spindle cell type

A morphologic variant of atypical fibroxanthoma characterized by the presence of spindle-shaped fibrohistiocytic cells and a storiform growth pattern.


Sellar Solitary Fibrous Tumor

An extremely rare meningeal solitary fibrous tumor that arises from the sellar region.


Recurrent Desmoid Fibromatosis

Desmoid fibromatosis that has recurred after a period of remission.


Uterine Corpus Hydropic Leiomyoma

A variant of leiomyoma arising from the uterine corpus. It is characterized by conspicuous zonal edema. Hyalinization may also be present.


Mesenteric Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor that arises from the mesentery. This is an extragastrointestinal tumor, meaning that it does not arise directly from the gastrointestinal tract.


undifferentiated sarcoma of soft tissue

A term that refers to a heterogeneous group of uncommon soft tissue sarcomas that do not show an identifiable line of differentiation using currently available technologies.  This is a diagnosis of exclusion and includes undifferentiated pleomorphic sarcoma (also known as malignant fibrous histiocytoma), undifferentiated spindle cell sarcoma, undifferentiated round cell sarcoma, and undifferentiated epithelioid sarcoma.


Locally Advanced Unresectable Malignant PEComa

A malignant PEComa that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Pleomorphic hyalinizing angiectatic tumor of soft tissue

A non-metastasizing soft tissue neoplasm characterized by the presence of a neoplastic stroma containing spindle cells, dilated thin-walled vessels lined by fibrin, and a chronic inflammatory infiltrate.  The majority of cases develop in the subcutaneous tissues usually in the lower extremities and present as slow growing masses.  Recurrences occur in approximately half of the cases.


Cellular fibroma

A morphologic variant of fibroma characterized by increased cellularity.


Central Nervous System Desmoid Fibromatosis

Intracranial and/or spinal involvement by desmoid fibromatosis.


Skin Radiation-Related Angiosarcoma

A malignant vascular neoplasm arising from an area of skin exposed to radiation therapy.


Peritoneal Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor that arises from the peritoneum. This is an extragastrointestinal tumor, meaning that it does not arise directly from the gastrointestinal tract.


Intermediate Soft Tissue Neoplasm

A soft tissue neoplasm characterized by an increased risk of local recurrence and/or a low risk of metastasis.


Gardner Fibroma

An uncommon, poorly circumscribed, benign neoplasm arising in the soft tissues of infants, children and adolescents. It is characterized by the presence of haphazardly arranged spindle-shaped fibroblasts, collagenous stroma formation, and plaque-like growth pattern. There is a strong genetic component associating the neoplasm with Gardners syndrome and deep fibromatosis/desmoid tumor.


Endocervical Undifferentiated Sarcoma

A high grade undifferentiated sarcoma that arises from the endocervix.


Stage I Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8

Stage I includes: IA: (T1, N0, M0, G1, GX); IB: (T2, T3, T4, N0, M0, G1, GX). T1: Tumor measuring 5 cm or less in greatest dimension. T2: Tumor measuring more than 5 cm and less than or equal to 10 cm in greatest dimension. T3: Tumor measuring more than 10 cm and less than or equal to 15 cm in greatest dimension. T4: Tumor measuring more than 15 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Total differentiation, mitotic count and necrosis score of 2 or 3. (AJCC 8th ed.)


Stage IB Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

Stage IB includes: T3, N0, M0, Low Mitotic Rate. T3: Tumor measuring more than 5 cm but not more than 10 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Stage IIIA Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

Stage IIIA includes: (T1, N0, M0, High Mitotic Rate); (T4, N0, M0, Low Mitotic Rate). T1: Tumor measuring 2 cm or less. T4: Tumor measuring more than 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Unresectable Soft Tissue Sarcoma

Soft tissue sarcoma that is not amenable to surgical resection.


Unresectable Desmoplastic Small Round Cell Tumor

A desmoplastic small round cell tumor that is not amenable to surgical resection.


Refractory Desmoid Fibromatosis

Desmoid fibromatosis that is resistant to treatment.


Maxillofacial Desmoplastic Fibroma

A rare, benign, locally aggressive osteolytic neoplasm that arises in a maxillofacial bone. It is characterized by the presence of a rich collagenous stroma and spindle cells with minimal cellular atypia.


Lymphangioleiomyomatosis of skin

Lymphangiomyomatosis involving the dermis.


Benign Skin Vascular Neoplasm

A benign vascular neoplasm that arises in the skin.


Stage I Adult Soft Tissue Sarcoma AJCC v7

Stage I includes: IA (T1a, N0, M0, G1, GX); (T1b, N0, M0, G1, GX); IB (T2a, N0, M0, G1, GX); (T2b, N0, M0, G1, GX).  T1a: Superficial tumor 5 cm or less in greatest dimension.  T1b: Deep tumor 5 cm or less in greatest dimension.  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Grade 1.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Oral Cavity Lipoma

A benign adipose tissue neoplasm of the oral cavity. It usually occurs within the lingual and buccal mucosa.


Paratesticular Deep (Aggressive) Angiomyxoma

A locally infiltrating, non-metastasizing angiomyxoma that arises from the paratesticular region.


Nuchal fibroma

A rare non-encapsulated and poorly circumscribed tumor that usually arises from the posterior neck. It is seen more frequently in men and is characterized by the presence of thick collagen fibers. It may recur but does not metastasize.


Meningeal Central Nervous System Solitary Fibrous Tumor, Grade 3

A solitary fibrous tumor that arises from the meninges. It most often corresponds to the tumor previously diagnosed as anaplastic hemangiopericytoma.


Stage IV Adult Soft Tissue Sarcoma AJCC v7

Stage IV includes: Any T, Any N, M1, Any G.  M1: Distant metastasis. (AJCC 7th ed.)


Abdominal Inflammatory Myofibroblastic Tumor

Inflammatory myofibroblastic tumor that arises from the abdominal cavity.


Benign Laryngeal Soft Tissue Neoplasm

A non-metastasizing soft tissue neoplasm that arises from the larynx.


Intermediate Lipomatous Neoplasm

A lipomatous neoplasm characterized by a high risk of local recurrence and no risk of metastasis.


Vascular neoplasm of skin

A benign, intermediate, or malignant vascular neoplasm that arises from the skin.


Angiomyofibroblastoma

A benign myofibroblastic neoplasm, usually arising in the pelviperineal region. It is characterized by the presence of neoplastic spindle to round cells, dilated thin walled vessels, and stromal edema.  Most patients present with painless circumscribed masses.


Metastatic Desmoplastic Small Round Cell Tumor

A desmoplastic small round cell tumor that has spread from the original site of growth to another anatomic site.


Metastatic Childhood Soft Tissue Sarcoma

A sarcoma that arises from the soft tissues during childhood and has spread from the original site of growth to another anatomic site.


Stage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8

Stage II includes: T1, N0, M0, G2, G3. T1: Tumor measuring 5 cm or less in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. G2: Total differentiation, mitotic count and necrosis score of 4 or 5. G3: Total differentiation, mitotic count and necrosis score of 6, 7, or 8. (AJCC 8th ed.)


Vulvar Solitary Fibrous Tumor

A rare solitary fibrous tumor that arises from the vulva.


Stage IIIB Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

Stage IIIB includes: T4, N0, M0, High Mitotic Rate. T4: Tumor measuring more than 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Epithelioid fibrous histiocytoma

A morphologic variant of fibrous histiocytoma of the skin. It is characterized by the presence of epithelioid fibrohistiocytic cells.


Parotid Gland Kaposi Sarcoma

A Kaposi sarcoma arising from the parotid gland.


Recurrent Malignant Myoepithelioma

The reemergence of a malignant myoepithelioma after a period of remission.


Stage IA Soft Tissue Sarcoma AJCC v7

Stage IA includes: (T1a, N0, M0, G1, GX); (T1b, N0, M0, G1, GX).  T1a: Superficial tumor 5 cm or less in greatest dimension.  T1b: Deep tumor 5 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Grade 1.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Esophageal Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that affects the esophageal wall.


Fascial fibroma

A benign fibrous tumor arising from the fascial connective tissue.


Stage IA Gastric Gastrointestinal Stromal Tumor

Stage IA includes: T1 or T2, N0, M0, Mitotic rate: Low.  T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm, but not more than 5 cm, in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Uterine Corpus Malignant PEComa

A malignant neoplasm with perivascular epithelioid cell differentiation arising from the uterine corpus. The neoplasm is usually a large size, and charcaterized by the presence of marked nuclear atypia, pleomorphism, increased mitotic activity, necrosis, and infiltrative margins.  The most common metastatic sites are lungs, lymph nodes, and bone. Patients present with a pelvic mass or abnormal bleeding.


Stage IV Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus endometrial stroma sarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Benign Pilar-Associated Mesenchyme Neoplasm

A benign mesenchymal neoplasm arising from the pilar sheath of the hair follicle.  Representative examples include fibrofolliculoma, perifollicular fibroma, pilar leiomyoma, and trichogenic myxoma.


Seminal Vesicle Mammary-Type Myofibroblastoma

An extramammary myofibroblastoma that affects the seminal vesicle.


Stage I Uterine Sarcoma AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor limited to the uterus.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


Malignant Cervical Soft Tissue Neoplasm

A rare malignant mesenchymal neoplasm that arises from the cervix.


Skin Intermediate Fibrohistiocytic Neoplasm

A borderline fibrohistiocytic neoplasm arising from the dermis and extending to the subcutaneous tissues.


Digestive System Sarcoma

A sarcoma that arises from the digestive system.


Stage III Uterine Sarcoma AJCC v7

Stage III includes: IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1-T3, N1, M0).  T1: Tumor limited to the uterus. T2: Tumor extends beyond the uterus, within the pelvis.  T3: Tumor infiltrates abdominal tissues.  T3a: Tumor infiltrates abdominal tissues, one side. T3b: Tumor infiltrates abdominal tissues, more than one side.  N0: No regional lymph node metastasis. N1: Regional lymph node metastasis.  M0: No distant metastasis.  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


Peritoneal Desmoplastic Small Round Cell Tumor

A desmoplastic small round cell tumor that occurs in the abdominal and/or pelvic peritoneum.


Stage II Adult Soft Tissue Sarcoma AJCC v7

Stage II includes: IIA (T1a, N0, M0, G2, G3); (T1b, N0, M0, G2, G3); IIB (T2a, N0, M0, G2); (T2b, N0, M0, G2).  T1a: Superficial tumor 5 cm or less in greatest dimension.  T1b: Deep tumor 5 cm or less in greatest dimension.  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G2: Grade 2.  G3: Grade 3. (AJCC 7th ed.)


Intermediate Fibroblastic Neoplasm

A locally aggressive or rarely metastasizing neoplasm that arises from the soft tissues.  It is characterized by the presence of neoplastic spindle-shaped fibroblasts.


Gastric Lymphangioma

A lymphangioma arising from the stomach.


Bladder Malignant PEComa

A malignant perivascular epithelioid cell tumor arising from the bladder.


Leiomyoma, Epithelioid

A benign or malignant gastrointestinal stromal tumor with epithelioid morphology.


Giant Cell Angioblastoma

A rare, slow-growing, locally aggressive soft tissue tumor characterized by the presence of oval to spindle cells forming concentric aggregates around small vessels.  Giant multinucleated cells are also present.


Undifferentiated Sarcoma, Not Otherwise Specified

An undifferentiated soft tissue sarcoma which cannot be further characterized.


Stage IB Uterine Sarcoma AJCC v7

Stage IB includes: T1b, N0, M0.  T1b: For leiomyosarcoma and endometrial stromal sarcoma: tumor more than 5 cm in greatest dimension.  For adenosarcoma: tumor invades to less than half of the myometrium.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Vulvar Superficial Myofibroblastoma

An uncommon benign polypoid or nodular mesenchymal neoplasm that arises in the vulvar region. It is characterized by the presence of oval or spindle-shaped cells in a collagenous stroma and is separated from the epidermis by a variably thick Grenz zone.


AIDS-Related Cervical Kaposi Sarcoma

A Kaposi sarcoma arising from the cervix in patients who are infected with the human immunodeficiency virus.


Laryngeal Granular Cell Tumor

A granular cell tumor that arises from the larynx.


Breast Angiolipoma

An angiolipoma that arises from the breast. The majority are located in the subcutaneous tissue overlying the breast parenchyma, rather than in breast parenchyma.


Stage IIIA Uterine Sarcoma AJCC v7

Stage IIIA includes: T3a, N0, M0.  T3a: Tumor infiltrates abdominal tissues, one side. N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


Skin Spindle Cell/Pleomorphic Lipoma

A spindle cell/pleomorphic lipoma arising from the skin.


Central Nervous System Angiolipoma

An angiolipoma that arises from the central nervous system.


Malignant Sinonasal Soft Tissue Neoplasm

A malignant soft tissue neoplasm that arises from the nasal cavity and paranasal sinuses.


Sclerosing PEComa

A tumor with perivascular epithelioid cell differentiation characterized by the presence of cords of neoplastic cells in a densely collagenous stroma.


Epithelioid Sarcoma NCI Grade 2

An epithelioid sarcoma with less than 15% necrosis.


Bladder Solitary Fibrous Tumor

A solitary fibrous tumor that arises from the bladder. Most tumors are benign.


Uterine Corpus Central Primitive Neuroectodermal Tumor

A rare uterine corpus malignant small round cell tumor with neuroglial differentiation. The prognosis is poor.


Undifferentiated Stromal Sarcoma

An infiltrating high grade mesenchymal tumor arising from the uterine corpus, cervix, vagina, and the ovary.


EBV-Positive Inflammatory Follicular Dendritic Cell Sarcoma of the Digestive System

An inflammatory follicular dendritic cell sarcoma that occurs in the digestive system and is consistently associated with Epstein-Barr virus.


Gastric and Omental Gastrointestinal Stromal Tumor by AJCC v8 Stage

A term that refers to the staging of gastric and omental gastrointestinal stromal tumor (GIST), following the rules of the TNM AJCC v8 classification system. (from AJCC 8th Ed.)


Mixed Cell Type Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor composed of a mixture of neoplastic epithelioid and spindle cells.


Conventional Extraskeletal Myxoid Chondrosarcoma

A well differentiated extraskeletal myxoid chondrosarcoma.


Skin Atypical Lipomatous Tumor/Well Differentiated Liposarcoma

A rare atypical lipomatous tumor/well differentiated liposarcoma arising from the skin.


Myxoid leiomyoma

A leiomyoma characterized by the presence of abundant myxoid matrix.


Hemangioendothelioma of skin

A vascular proliferation arising from the skin.  It is characterized by the presence of prominent endothelial cells and formation of vascular channels.


Malignant Laryngeal Soft Tissue Neoplasm

A malignant soft tissue neoplasm that arises from the larynx.


Degeneration of uterine fibroid

A morphologic variant of uterine corpus leiomyoma characterized by the presence of hyalinized or myxoid stroma, edema, cystic changes, hemorrhage, and calcifications.


Undifferentiated Epithelioid Sarcoma

An undifferentiated soft tissue sarcoma characterized by the presence of a malignant cellular infiltrate with epithelioid morphology.


Stage IV Soft Tissue Sarcoma AJCC v7

Stage IV includes: Any T, Any N, M1, Any G.  M1: Distant metastasis. (AJCC 7th ed.)


Gastrointestinal Stromal Tumor by AJCC v8 Stage

A term that refers to the staging of gastrointestinal stromal tumor (GIST), following the rules of the TNM AJCC v8 classification system. This staging system does not apply to pediatric GIST, familial GIST (germline mutant KIT or PDGFRA), or syndromic GIST (no AJCC staging system available). (from AJCC 8th Ed.)


Stage IIIB Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

Stage IIIB includes: (T2, N0, M0, High Mitotic Rate); (T3, N0, M0, High Mitotic Rate); (T4, N0, M0, High Mitotic Rate). T2: Tumor measuring more than 2 cm but not more than 5 cm. T3: Tumor measuring more than 5 cm but not more than 10 cm. T4: Tumor measuring more than 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Vulvar Angiomyofibroblastoma

An angiomyofibroblastoma arising from the vulva.


A morphologic variant of dermatofibrosarcoma protuberans characterized by the presence of poorly differentiated sarcomatous components.


Vaginal Low Grade Endometrioid Stromal Sarcoma

An infiltrating sarcoma that arises from the vagina.  It is characterized by the presence of cells that resemble endometrial stromal cells.


Fallopian Tube Soft Tissue Neoplasm

A benign or malignant mesenchymal neoplasm of the fallopian tube.  Representative examples include leiomyoma and leiomyosarcoma.


Stage IIIA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8

Stage IIIA includes: T2, N0, M0, G2, G3. T2: Tumor measuring more than 5 cm and less than or equal to 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. G2: Total differentiation, mitotic count and necrosis score of 4 or 5. G3: Total differentiation, mitotic count and necrosis score of 6, 7, or 8. (AJCC 8th ed.)


Bladder Soft Tissue Neoplasm

A mesenchymal neoplasm that arises from the bladder.


Superficial angiomyxoma

An angiomyxoma arising from the dermis or subcutaneous tissues.  It may recur following resection.


Stage III Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

Stage III includes: IIIA: (T3, N0, M0, High Mitotic Rate); IIIB: (T4, N0, M0, High Mitotic Rate). T3: Tumor measuring more than 5 cm but not more than 10 cm. T4: Tumor measuring more than 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Resectable Soft Tissue Sarcoma

Soft tissue sarcoma that is amenable to surgical resection.


Epithelioid sarcoma non-metastatic

Epithelioid sarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Desmoplastic fibroblastoma

A rare benign soft tissue neoplasm characterized by the presence of an abundant collagenous or myxocollagenous matrix, spindle-shaped, and stellate-shaped fibroblasts.  It usually presents as an asymptomatic, slowly growing subcutaneous mass. The most common sites of involvement are the upper arm, shoulder, and lower limb.


Uterine Corpus Leiomyoma, Mitotically Active Variant

A morphologic variant of uterine corpus leiomyoma characterized by an increased number of mitoses (up to 19 mitoses per 10 high-powered fields).


Sinonasal Soft Tissue Neoplasm

A soft tissue neoplasm that arises from the nasal cavity and paranasal sinuses.


Recurrent Childhood Soft Tissue Sarcoma

The reemergence of soft tissue sarcoma in childhood after a period of remission.


Lacrimal Gland Myoepithelial Carcinoma

A carcinoma that arises from the lacrimal gland. It is characterized by the presence of a malignant cellular infiltrate exhibiting myoepithelial differentiation.


Optic Nerve Sheath Solitary Fibrous Tumor

A rare solitary fibrous tumor that arises from the optic nerve sheath.


Metastatic Malignant PEComa

A malignant PEComa that has spread from its original site of growth to another anatomic site.


Stage IA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus, measuring 5 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Central Nervous System Inflammatory Myofibroblastic Tumor

A multinodular intermediate fibroblastic neoplasm affecting the central nervous system.  It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.


An extramammary myofibroblastoma that arises from the paratesticular region.


Soft Tissue Sarcoma of the Trunk and Extremities

A soft tissue sarcoma that arises from the trunk or the extremities.


Stage II Gastric Gastrointestinal Stromal Tumor

Stage II includes: (T1, N0, M0, Mitotic rate: High); (T2, N0, M0, Mitotic rate: High); (T4, N0, M0, Mitotic rate: Low). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm, but not more than 5 cm, in greatest dimension.  T4: Tumor more than 10 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Recurrent Desmoplastic Small Round Cell Tumor

The reemergence of desmoplastic small round cell tumor after a period of remission.


Stromal Neoplasm

A benign or malignant mesenchymal neoplasm composed of stromal cells.  Representative examples include gastrointestinal stromal tumor, endometrial stromal sarcoma, and prostate stromal sarcoma.


NTRK-Rearranged Spindle Cell Neoplasm

An emerging rare group of soft tissue tumors, usually characterized by a monomorphic spindle cell infiltrate, stromal hyalinization, and frequent coexpression of S100 and CD34 by immunohistochemistry. Most tumors harbor NTRK1 fusions with a variety of partners. Rare cases involving NTRK2 and NTRK3 fusions have also been reported.


Classic Type Atypical Fibroxanthoma

A morphologic variant of atypical fibroxanthoma characterized by the presence of atypical mitotic figures, high mitotic activity, and pleomorphic cells.


Conjunctival Angiosarcoma

An angiosarcoma that arises from the conjunctiva.


Fibromatosis, Abdominal

An insidious poorly circumscribed neoplasm arising from the deep soft tissues of the abdomen. It is characterized by the presence of elongated spindle-shaped fibroblasts, collagenous stroma formation, and an infiltrative growth pattern.


Soft Tissue Tumor of Uncertain Differentiation

A benign,intermediate, or malignant mesenchymal neoplasm in which the line of differentiation is uncertain.  Representative examples include neoplasm with perivascular epithelioid cell differentiation, alveolar soft part sarcoma, desmoplastic small round cell tumor, epithelioid sarcoma, extraskeletal myxoid chondrosarcoma, and synovial sarcoma.


Benign Gastric Soft Tissue Neoplasm

A non-metastasizing mesenchymal neoplasm of the stomach.  Representative examples include leiomyoma, lipoma, and hemangioma.


Stage IV Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

Stage IV includes: (Any T, N1, M0, Any Mitotic Rate); (Any T, Any N, M1, Any Mitotic Rate). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Vulvar Prepubertal Fibroma

A rare, benign mesenchymal neoplasm that arises from the vulvar region, usually the labia majora of prepubertal girls. It presents as a slow-growing, unilateral painless mass. It is characterized by an infiltrative growth of bland spindle cells in a collagenous, edematous, or myxoid stroma. It may recur following incomplete excision.


Prostate Inflammatory Myofibroblastic Tumor

A rare inflammatory myofibroblastic tumor that arises from the prostate gland.


Locally Invasive Desmoid-Type Fibromatosis

Desmoid-type fibromatosis that has invaded the surrounding tissues.


Superficial Acral Fibromyxoma

A benign fibroblastic neoplasm that arises from acral sites, usually the periungual area of the digits.  It is characterized by the proliferation of spindled and stellate-shaped fibroblasts in the dermis in a myxoid or collagenous stroma.  Nuclear atypia is usually minimal.  It usually presents as a solitary and slow-growing dome-shaped mass on a digit. The recurrence rate is low.


Paratesticular Cellular Angiofibroma

A cellular angiofibroma that arises from the paratesticular region.


Stage IIIB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8

Stage IIIB includes: T3, T4, N0, M0, G2, G3. T3: Tumor measuring more than 10 cm and less than or equal to 15 cm in greatest dimension. T4: Tumor measuring more than 15 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. G2: Total differentiation, mitotic count and necrosis score of 4 or 5. G3: Total differentiation, mitotic count and necrosis score of 6, 7, or 8. (AJCC 8th ed.)


Dermatofibrosarcoma protuberans with myoid differentiation

A morphologic variant of dermatofibrosarcoma protuberans characterized by the presence of areas of myofibroblastic differentiation.


Advanced Malignant PEComa

A malignant PEComa that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Malignant Gastrointestinal Stromal Tumor

Malignant gastrointestinal stromal tumor that is not amenable to surgical resection.


Stage IB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8

Stage IB includes: T2, T3, T4, N0, M0, G1, GX. T2: Tumor measuring more than 5 cm and less than or equal to 10 cm in greatest dimension. T3: Tumor measuring more than 10 cm and less than or equal to 15 cm in greatest dimension. T4: Tumor measuring more than 15 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Total differentiation, mitotic count and necrosis score of 2 or 3. (AJCC 8th ed.)


Pulmonary Artery Angiosarcoma

A malignant vascular neoplasm arising from the pulmonary artery.


Appendix Kaposi Sarcoma

A rare Kaposi sarcoma that arises from the appendiceal wall.


Recurrent Gastrointestinal Stromal Tumor

The reemergence of a gastrointestinal stromal tumor after a period of remission.


Breast Atypical Myoepitheliosis

A neoplastic process characterized by the proliferation of spindle to cuboidal myoepithelial cells in and around small breast ducts exhibiting cytologic atypia and mitotic activity.


Angiosarcoma of the Skin of the Arm after Radical Mastectomy followed by Lymphedema

An angiosarcoma arising from the skin of the arm following radical mastectomy and resulting lymphedema.


Vaginal Deep (Aggressive) Angiomyxoma

A locally infiltrating, non-metastasizing vaginal angiomyxoma.  It may recur following resection.


Malignant Soft Tissue Tumor of Uncertain Differentiation

A malignant soft tissue tumor in which the line of differentiation is uncertain.


Skin Myoepithelioma

A benign skin neoplasm composed exclusively of myoepithelial cells.


Intermediate Sinonasal Soft Tissue Neoplasm

A soft tissue neoplasm that arises from the sinonasal tract and is characterized by an increased risk of local recurrence and/or a low risk of metastasis.


Gastric Gastrointestinal Stromal Tumor of Uncertain Malignant Potential

A gastrointestinal stromal tumor arising from the stomach.  It is characterized by a maximum diameter greater than 5 cm and equal or less than 10 cm and no more than 5 mitotic figures per 50 high power fields.


Vulvar Superficial Angiomyxoma

A vulvar angiomyxoma arising from the dermis or subcutaneous tissues. It may recur following resection.


A rare variant of dermatofibrosarcoma protuberans characterized by plaque-like growth, resembling plaque-like CD34-positive dermal fibroma.


Prostate Malignant Solitary Fibrous Tumor

A rare malignant solitary fibrous tumor that arises from the prostate gland.


Hepatobiliary Soft Tissue Neoplasm

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the hepatobiliary system.


Thyroid Gland Leiomyoma

A leiomyoma that arises from the thyroid gland.


Atypical fibroxanthoma of skin

An intermediate cutaneous mesenchymal neoplasm of uncertain differentiation, usually affecting the actinic-damaged skin of the elderly.  The tumor presents as a single cutaneous nodule which is often ulcerated.  Microscopically, it is characterized by the presence of highly atypical cytologic features, pleomorphism and abundant mitotic figures. The vast majority of patients have an excellent prognosis following conservative therapy. Recurrences are infrequent, and metastasis is rare.


Skin Fibrous Histiocytoma, Fibroblastic Variant

A morphologic variant of fibrous histiocytoma of the skin. It is characterized by the presence of spindle-shaped fibrohistiocytic cells and associated acanthosis.


Soft Tissue Sarcoma by AJCC v7 Stage

A term that refers to the staging of soft tissue sarcoma, following the rules of the TNM AJCC v7 classification system.


An epithelioid hemangioendothelioma that arises from the nasal cavity and paranasal sinuses.


Intracranial Fibrous Histiocytoma

A benign fibrous histiocytoma involving the dura or cranial bone.


Intracranial lipoma

A rare benign adipose tissue neoplasm located in the intracranial region. It is a congenital hamartomatous malformation derived from the embryologic meninx primitiva.


Kaposi Sarcoma Related to Immunosuppressive Treatment

A Kaposi sarcoma that develops after immunosuppressive treatment.


Digestive System Inflammatory Myofibroblastic Tumor

A multinodular intermediate fibroblastic neoplasm arising from the digestive system. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.


Pelvic Fibromatosis

Fibromatosis that occurs in the pelvis. It affects almost always females. It is characterized by the presence of elongated spindle-shaped fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. It recurs if incompletely resected but lacks metastatic potential.


Paratesticular Schwannoma

A schwannoma that arises from the paratesticular region.


Stage IIIC Uterine Sarcoma AJCC v7

Stage IIIC includes: T1-T3, N1, M0.  T1: Tumor limited to the uterus. T2: Tumor extends beyond the uterus, within the pelvis.  T3: Tumor infiltrates abdominal tissues.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


Uterine Angiosarcoma

A malignant vascular neoplasm arising from the uterus.


Stage III Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IVA Uterine Sarcoma AJCC v7

Stage IVA includes: T4, Any N, M0. T4: Tumor involves bladder or rectum.  M0: No distant metastasis.  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


Gastric sarcoma

A sarcoma that arises from the stomach. Representative examples include Kaposi sarcoma, leiomyosarcoma, and liposarcoma.


Recurrent Skin Angiosarcoma

The reemergence of skin angiosarcoma after a period of remission.


Intermediate Soft Tissue Tumor of Uncertain Differentiation

A soft tissue tumor of uncertain differentiation which is locally aggressive but rarely metastasizes.


Uterine Corpus Sarcoma by AJCC v8 Stage

A term that refers to the staging of uterine corpus sarcoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to leiomyosarcomas, endometrial stromal sarcomas, and adenosarcomas of the uterine corpus. It does not apply to carcinosarcomas which are staged according to the carcinomas and carcinosarcomas of the uterine corpus. (from AJCC 8th Ed.)


Cervical Low Grade Endometrioid Stromal Sarcoma

A very rare sarcoma that arises from the cervix and is characterized by the presence of cells that resemble endometrial stromal cells.


Kaposi Sarcoma NCI Grade 2

A Kaposi sarcoma with less than 15% necrosis.


Lipofibromatosis

A rare, slow-growing, painless tumor of infancy and early childhood that usually affects the distal extremities. It is characterized by the presence of alternating bands of mature adipose tissue and spindle-cell fibrous tissue, without destruction of the adipose tissue architecture. It does not metastasize, however the rate of local recurrences is high.


Malignant vascular tumor of skin

A malignant vascular neoplasm arising from blood vessels and lymphatics of the skin.


EWSR1-SMAD3-Positive Fibroblastic Tumor

A benign fibroblastic neoplasm characterized by a fusion of exon 7 of EWSR1 gene with exon 5 of SMAD3 gene. Patients usually present with a small painless superficial tumor in the hands and feet. Morphologically, there is zonation with acellular hyalinized center and peripheral proliferation of fibroblastic spindle cells without atypia. It may recur following incomplete excision.


Unresectable Undifferentiated Pleomorphic Sarcoma

Undifferentiated pleomorphic sarcoma that is not amenable to surgical resection.


Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8

Stage III includes: IIIA: (T2, N0, M0, G2, G3); IIIB: (T3, T4, N0, M0, G2, G3). T2: Tumor measuring more than 5 cm and less than or equal to 10 cm in greatest dimension. T3: Tumor measuring more than 10 cm and less than or equal to 15 cm in greatest dimension. T4: Tumor measuring more than 15 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. G2: Total differentiation, mitotic count and necrosis score of 4 or 5. G3: Total differentiation, mitotic count and necrosis score of 6, 7, or 8. (AJCC 8th ed.)


Atypical Ductal Breast Hyperplasia

A neoplastic process that arises from the terminal ductal lobular unit of the breast parenchyma.  It is usually solitary and confined to a single lobular unit.  It is characterized by the presence of a monomorphic epithelial proliferation in a cribriform, micropapillary, or solid growth pattern.  Focal architectural features of low grade ductal carcinoma in situ are present.  There is an increased risk for development of invasive breast carcinoma.


Grade 3 Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE

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Skin Breakdown or Decubitus Ulcer, CTCAE


Grade 2 Skin Breakdown or Decubitus Ulcer, CTCAE


Grade 4 Skin Breakdown or Decubitus Ulcer, CTCAE


Grade 5 Skin Breakdown or Decubitus Ulcer, CTCAE


Prostate Large Cell Neuroendocrine Carcinoma

An exceptionally rare neuroendocrine carcinoma that arises from the prostate gland.  It is characterized by the presence of malignant large cells.


Postpartum Obstetric Thromboembolism

Presence of a blood clot in the maternal vascular system which originated from a distant site during the postpartum period.


Ampulla of Vater Neuroendocrine Tumor G1

A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The mitotic count is less than 2 per 10 HPF.


Grade 1 Intraoperative Renal Injury, CTCAE

Primary repair of injured organ/structure indicated


Osteolytic Lesions of Multiple Myeloma

A radiologic finding indicating the presence of multiple radiolucent osteolytic bone lesions observed in a patient with a diagnosis of multiple myeloma.


Solitary Lytic Metastatic Bone Lesion

A radiologic finding indicating the presence of solitary area of bone destruction that results from the spread of cancer to the bone(s).


An aldohexose used as a source of energy and metabolic intermediate.


Laryngeal Fistula

An abnormal communication between the larynx and another organ or cavity.


Pharyngocutaneous fistula

An abnormal communication between the skin and the pharynx.


Salivary Gland Fistula

An abnormal communication between a salivary gland and another organ or anatomic site.


External Auditory Canal Fistula

An abnormal communication between the external auditory canal and the adjacent tissues.


Grade 5 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Locally Advanced Liposarcoma

A liposarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Liposarcoma metastatic

A liposarcoma that has metastasized to a secondary site.


Metastatic Dedifferentiated Liposarcoma

Dedifferentiated liposarcoma that has spread from its original site of growth to another anatomic site.


Advanced Myxoid Liposarcoma

A myxoid liposarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Myxoid liposarcoma metastatic

Myxoid liposarcoma that has spread to other anatomic sites.


Advanced Dedifferentiated Liposarcoma

A dedifferentiated liposarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Dedifferentiated Liposarcoma

Dedifferentiated liposarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Liposarcoma

A liposarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Multinodular and Vacuolated Neuronal Tumor

The reemergence of multinodular and vacuolated neuronal tumor following a period of remission.


Grade 5 Ovarian Infection, CTCAE

Death


Stage IV Ureter Cancer AJCC v8

Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat. N0: No regional lymph node metastasis. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm in greatest dimension; or multiple lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Grade 5 Mucosal Infection, CTCAE

Death


Cleft Maxilla

A congenital abnormality consisting of a fissure in the midline of the upper jawbone.


Fallopian Tube Lymphoma

An exceedingly rare lymphoma that arises from the fallopian tube.


Grade 3 Lower Extremity Vein Injury, CTCAE


Grade 4 Lower Extremity Vein Injury, CTCAE


Grade 2 Lower Extremity Vein Injury, CTCAE


Grade 1 Lower Extremity Vein Injury, CTCAE


Grade 5 Lower Extremity Vein Injury, CTCAE


Gastric melanoma

A melanoma that arises from mucosa of the stomach.


The (R)-enantiomer of bromazine.


Grade 2 Oral Cavity or Gum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Oral Cavity or Gum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Oral Cavity or Gum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Oral Cavity or Gum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Oral Cavity or Gum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


straight-chain fatty acid

Any fatty acid whose skeletal carbon atoms form an unbranched open chain.


linolenic acid

A two-membered subclass of octadecatrienoic acid comprising the (9Z,12Z,15Z)- and (6Z,9Z,12Z)-isomers. Linolenic acids are nutrients essential to the formation of prostaglandins and are also used in making paints and synthetic resins.


octadecadienoic acid

Any straight-chain, C18 polyunsaturated fatty acid having two C=C double bonds.


2-Undecenoic acid

A 2-undecenoic acid in which the olefinic double bond has E configuration.


octadecatrienoic acid

Any trienoic fatty acid having eighteen carbons.


The (5Z,7E,9E,14Z,17Z)-isomer of icosapentaenoic acid.


Hendecenoic acid

An undecenoic acid having its double bond in the 2-position.


cis-9-Undecenoic acid

The cis-isomer of 9-undecenoic acid.


Undec-9-enoic acid

An undecenoic acid having its double bond in the 9-position.


8-Undecenoic acid

An undecenoic acid having its double bond in the 8-position.


9-Undecenoic acid

The trans-isomer of 9-undecenoic acid.


Head and Neck Disorder

A non-neoplastic or neoplastic disorder that affects the anatomic structures of the head and neck region.  This category includes inflammatory disorders, benign neoplasms, precancerous conditions, and malignant neoplasms.


Thyroid Gland Lipoadenoma

A thyroid gland adenoma composed of follicular structures and mature adipocytes.


Nasopharyngeal Paraganglioma

An extra-adrenal paraganglioma arising from the nasopharynx and nose.  Epistaxis or nasal obstruction are common presenting symptoms.


Follicular ameloblastoma

A histologic variant of solid/multicystic ameloblastoma characterized by the presence of odontogenic epithelial islands in a fibrotic stroma.


Recurrent Malignant Neoplasm of Salivary Gland

The reemergence of a malignant salivary gland neoplasm after a period of remission.


Malignant odontogenic tumor

A sarcoma that arises from tooth-forming tissues.


Salivary Gland Lipoma

A lipoma that arises from a salivary gland. It usually occurs in the parotid gland.


Sellar Neurocytoma

A rare extraventricular neurocytoma (WHO grade 2) of the hypothalamic-pituitary area. (WHO 2017)


Squamous odontogenic tumor

A rare, locally invasive neoplasm arising from tooth-forming tissues. It usually grows intraosseously in the mandible. The maxilla is less frequently involved. It is characterized by the presence of well differentiated squamous cells which form islands. Recurrences may rarely occur and probably are related to incomplete excision of the tumor.


Parotid Gland Hemangioma

A hemangioma arising from the parotid gland.


Malignant Ameloblastoma

A rare, well differentiated, cytologically benign ameloblastoma which paradoxically metastasizes.


Sellar Choriocarcinoma

A choriocarcinoma that arises from or adjacent to the sellar region.


Oral Intraepithelial Neoplasia

A precancerous neoplastic process affecting the oral mucosa. It is characterized by the presence of dysplasia in the mucosal epithelium.


Thyroid Gland Follicular Tumor of Uncertain Malignant Potential

An encapsulated or well-circumscribed thyroid gland tumor composed of well-differentiated follicular cells with no nuclear features of papillary thyroid carcinoma and with questionable capsular or vascular invasion. This is a tumor indeterminate between follicular adenoma and follicular carcinoma. (WHO)


Non-Neoplastic Laryngeal Disorder

A non-neoplastic pathologic process that affects the larynx.  Representative examples include laryngitis, vocal cord nodule, and laryngeal cleft.


Advanced Malignant Head and Neck Neoplasm

A malignant neoplasm that arises from the head and neck region and has spread extensively to other anatomic sites or is no longer responding to treatment.


Sellar Yolk Sac Tumor

A yolk sac tumor that arises from or adjacent to the sellar region.


Head and Neck Precancerous Condition

A premalignant pathologic process that affects the anatomic structures of the head and neck.  Representative examples include oral leukoplakia and leukoplakia of the vocal cords.


Non-Neoplastic Oral Disorder

A non-neoplastic disorder that affects the oral cavity or the lips.


Minor Salivary Gland Intraductal Papillary Neoplasm

A rare papillary neoplasm that grows within and is limited to the duct system of the minor salivary glands. This category includes papillary cystadenoma, ductal papilloma (including the intraductal and inverted variants), sialadenoma papilliferum, and intraductal papillary mucinous neoplasm.


Iodine-induced hyperthyroidism

Iodine-induced hyperthyroidism.


Low Risk Thyroid Gland Neoplasm

A thyroid gland neoplasm in which the incidence of metastatic spread is extremely low. This category includes thyroid gland noninvasive follicular neoplasm with papillary-like nuclear features, thyroid gland hyalinizing trabecular tumor, and thyroid gland tumors of uncertain malignant potential.


Sellar Paraganglioma

An extremely rare paraganglioma arising from chief cells of the dispersed paraganglia of the sellar region. (WHO)


Metastatic malignant neoplasm to orbit

A malignant neoplasm that has spread to the orbit from another anatomic site.


Congenital thyroid disorder

A thyroid gland disorder present at birth. It includes thyroid gland aplasia and thyroid gland hypoplasia, both result in hypothyroidism.


Sellar Immature Teratoma

An immature teratoma that arises from or adjacent to the sellar region.


Congenital hypothyroidism with ectopic thyroid

Thyroid hormone deficiency present at birth that is associated with ectopic thyroid tissue located in the neck region.


Non-Neoplastic Nasal Cavity Disorder

A non-neoplastic disorder that affects the nasal cavity.  Representative examples include rhinitis and Wegener granulomatosis.


Jugular Foramen Neoplasm

A neoplasm that affects the jugular foramen.  Representative examples include paraganglioma, schwannoma, and meningioma.


Salivary Gland Sebaceous Lymphadenoma

A rare, benign epithelial neoplasm composed of irregular proliferating nests and islands of epithelium, including solid and gland-like sebaceous elements, surrounded by lymphoid stroma. Most occur in the parotid gland. Symptoms include a progressively enlarging, painless mass.  Sebaceous lymphadenocarcinoma is the malignant counterpart.


Benign Sinonasal Neoplasm

A non-metastasizing neoplasm that arises from the nasal cavity and paranasal sinuses.


Hard Palate Monomorphic Adenoma

A benign epithelial neoplasm arising from the minor salivary glands in the hard palate. It is characterized by the presence of a monomorphic cellular infiltrate.


Malignant Parapharyngeal Neoplasm

A primary or metastatic malignant neoplasm that affects the parapharyngeal space.


Benign Inner Ear Neoplasm

A non-metastasizing neoplasm that arises from the inner ear. Representative examples include vestibular schwannoma and lipoma.


Non-Neoplastic Tonsillar Disorder

A non-neoplastic disorder that affects the tonsils.


Atypical Parathyroid Gland Tumor

A parathyroid gland tumor that shares certain morphologic characteristics with parathyroid gland carcinomas (e.g. broad fibrous bands formation with or without hemosiderin deposition, presence of mitotic figures) but lacks unequivocal evidence of capsular or vascular invasion. It is considered a tumor of uncertain malignant potential. (WHO)


Disorder of neck

A non-neoplastic or neoplastic disorder that affects the anatomic structures of the neck region.  This category includes disorders of the pharynx, larynx, thyroid gland, and parathyroid gland.


Metastatic Malignant Head and Neck Neoplasm

A malignant neoplasm that arises from the head and neck region and has spread to another anatomic site.


Odontogenic tumor, benign

A benign, slow growing neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial skeleton or the gingiva. Representative examples include adenomatoid odontogenic tumor, calcifying cystic odontogenic tumor, and squamous odontogenic tumor.


Benign neoplasm of orbit

A non-metastasizing neoplasm that arises from the orbit.


Iatrogenic Central Hypothyroidism

Central hypothyroidism due to medical or surgical treatment.


Congenital hyperthyroidism

Hyperthyroidism, the cause of which is present at birth.


Sellar Meningioma

A rare meningioma that arises from the sellar region.


Rhinosinusitis

Inflammation of the mucous membranes lining the nose and paranasal sinuses.


Non-Neoplastic Thyroid Gland Disorder

A non-neoplastic disorder that affects the thyroid gland.  Representative examples include hyperthyroidism, hypothyroidism, thyroiditis, and thyroid gland abscess.


Parapharyngeal Neoplasm

A benign or malignant neoplasm that affects the parapharyngeal space.


Singers' nodes

A non-neoplastic growth in the vocal cord. It is characterized by tissue swelling in both vocal cords in a symmetrical manner. It is caused by vocal abuse behavior. Hoarseness is the presenting symptom.


Nasopharyngeal Non-Neoplastic Disorder

A non-neoplastic disorder that affects the nasopharynx.


Suprasellar germ cell tumor

A germ cell tumor that arises from the suprasellar region.


Ameloblastic Fibrosarcoma

A locally aggressive malignant neoplasm arising from odontogenic tissue. It occurs in the mandible and less often in the maxilla.  It is characterized by the presence of a malignant connective tissue component and a benign epithelial component.  The frequency of distal metastases is low.


Sellar Germinoma

A germinoma that arises from or adjacent to the sellar region.


Ceruminous Neoplasm

An adenoma or carcinoma that arises from the ceruminous glands in the external auditory canal.


Laryngeal Precancerous Condition

A premalignant pathologic process that affects the epithelial cells of the laryngeal mucosa.


Non-Neoplastic Neck Disorder

A non-neoplastic disorder that affects the anatomic structures of the neck region.  This category includes non-neoplastic disorders of the pharynx, larynx, thyroid gland, and parathyroid gland.


Ameloblastic fibroma

A rare neoplasm arising from tooth-forming tissues. It usually arises from the posterior mandible. It is characterized by the presence of an epithelial component and fibromyxoid stroma. It may recur and rarely shows malignant transformation to ameloblastic fibrosarcoma. It is treated with enucleation and curettage.


Nasal Cavity Exophytic Papilloma

A benign nasal cavity exophytic papillary neoplasm with fibrovascular cores lined by epithelial cells. It arises from the lower anterior nasal septum. Clinical manifestations include nasal obstruction, epistaxis, and the presence of a mass.


Leukoplakia of lips

A clinical term that indicates the presence of a white patch on the surface of the lip which cannot be characterized as any other disease.  It may be a precancerous condition and in most cases histologic examination reveals keratosis.


Parotid monomorphic adenoma

A benign epithelial neoplasm that arises from the parotid gland. It is characterized by the presence of a monomorphic cellular infiltrate.


Benign Anterior Tongue Neoplasm

A non-metastasizing neoplasm that arises from the anterior portion of the tongue.


Benign Ameloblastoma

An ameloblastoma that does not recur or metastasize.


Oral neoplasm malignant recurrent

Reemergence of a lip or oral cavity malignant neoplasm after a period of remission.


Nasopharyngeal Lymphoma

A lymphoma that arises from the nasopharynx.


Central Hyperthyroidism

Overproduction of thyroid hormones due to a disorder originating within the hypothalamic-pituitary axis.


Thyroglobulin Deficiency

Subnormal production of thyroglobulin, the glycoprotein precursor of thyroid hormones, presumed to result from loss-of-function mutation(s) in the TG gene.


Head and Neck Langerhans Cell Histiocytosis

Langerhans cell histiocytosis involving the head and neck.


sarcoma of oral cavity

A malignant soft tissue neoplasm that arises from the oral cavity.  Representative examples include Kaposi sarcoma and angiosarcoma.


Nasopharyngeal Hodgkin Lymphoma

A Hodgkin lymphoma that arises from the nasopharynx.


Smokers keratosis

A premalignant pathologic process that affects the oral mucosa.  It is associated with the use of smoked tobacco.  It appears as white lesions on the oral mucosa.  Morphologically it is characterized by the pathologic production of keratin in the mucosal epithelial surface with or without epithelial atypia.  It may reverse with the cessation of tobacco use.


Defective Thyroglobulin Transport

Impairment in the intracellular transport of thyroglobulin.


Paranasal sinus and nasal cavity malignant neoplasm

A primary or metastatic malignant neoplasm involving the nasal cavity and paranasal sinuses.


Oropharyngeal Hodgkin Lymphoma

A Hodgkin lymphoma that arises from the oropharynx.


Extraosseous/Peripheral Ameloblastoma

An ameloblastoma that arises from the soft tissues in the gingiva or alveolar mucosa.  It presents as a painless exophytic mass.


Head and Neck Histiocytic and Dendritic Cell Neoplasm

A histiocytic and dendritic cell neoplasm that affects the head and neck.


Locally Advanced Malignant Head and Neck Neoplasm

A malignant neoplasm that arises from the head and neck region and has spread from its original site of growth to nearby tissues or lymph nodes.


Thyroid Gland Clear Cell Follicular Adenoma

A thyroid gland adenoma composed of follicular cells with cytoplasmic clearing.


Parotid Gland Sialolipoma

A benign parotid gland neoplasm composed of mature adipose tissue and epithelial tissue.


Non-Neoplastic Parathyroid Gland Disorder

A non-neoplastic disorder that affects the parathyroid glands.  Representative examples include hyperparathyroidism and hypoparathyroidism.


Benign Parapharyngeal Neoplasm

A benign neoplasm that arises from the parapharyngeal space.


Sellar Mature Teratoma

A mature teratoma that arises from or adjacent to the sellar region.


Oropharyngeal Lymphoma

A lymphoma that arises from the oropharynx.


Hemangioma of salivary gland

A hemangioma that arises from a salivary gland. It occurs almost exclusively in the parotid gland.


Thyroid Gland Rosai-Dorfman Disease

Sinus histiocytosis with massive lymphadenopathy affecting the thyroid gland. It is rare and is usually accompanied by involvement of cervical lymph nodes.


Adenoma, Monomorphic

A benign epithelial neoplasm arising from the salivary glands. It is characterized by the presence of a monomorphic cellular infiltrate.


Non-Neoplastic Middle Ear Disorder

A non-neoplastic disorder that affects the middle ear.


Oral Cavity Monomorphic Adenoma

A benign epithelial neoplasm arising from the salivary glands in the oral cavity. It is characterized by the presence of a monomorphic cellular infiltrate.


Thyroid Gland Follicular Adenoma with Papillary Hyperplasia

A thyroid gland adenoma characterized by the presence of papillae lined by cells that range from cuboidal to columnar. The papillae are usually cystic and non-branching. Aggregates of follicles may be found within the papillary structures.


Oropharyngeal Polyp

A benign exophytic growth that arises from the oropharynx.


Dental surface disorders

A disorder that affects the surface of the tooth.


Abscess of thyroid

A rare disorder characterized by the development of an abscess in the thyroid gland.  It usually follows an upper respiratory tract, pharyngeal, or middle ear infection.  It is usually caused by Staphylococcus or Streptococcus infection.  It presents with fever, pain, and neck mass.


Salivary gland adenoma

A benign adenoma that arises from the salivary gland. This group includes pleomorphic adenoma, canalicular adenoma, basal cell adenoma, and sebaceous adenoma.


Orbital Melanoma

A melanoma that arises from the structures of the orbit.


Primordial Odontogenic Tumor

A benign odontogenic tumor composed of variably cellular loose fibrous tissue with areas similar to the dental papilla, entirely surrounded by cuboidal to columnar epithelium resembling the internal epithelium of the enamel organ. It occurs intraosseously, with a marked preference for the mandible. (WHO 2017)


Mouth Mucous Membrane Leukoplakia

A clinical term that indicates the presence of a white patch on the mucous membrane in the mouth which cannot be characterized as any other disease.  It may be a precancerous condition and in most cases histologic examination reveals keratosis.


Pharyngeal Melanoma

A melanoma that arises from the mucosal surface of the pharynx.


Benign Head and Neck Neoplasm

A non-metastasizing neoplasm that arises from the head and neck.


Salivary Gland Lymphadenomas

A rare benign salivary gland tumor that consists of a well-circumscribed biphasic proliferation of epithelial cells and reactive lymphoid tissue. Sebaceous and non-sebaceous forms can be distinguished. (WHO 2017)


Agenesis of larynx

A congenital deformity in which there is no laryngeal structure.


Wolff-Chaikoff Phenomenon

Hypothyroidism induced by excessive levels of iodine in the blood.


ductal papilloma of salivary gland

A benign papillary neoplasm that arises from the salivary glands.  This category includes intraductal papilloma, inverted ductal papilloma, and sialadenoma papilliferum.


Metastatic malignant neoplasm to lip

A malignant neoplasm that has spread to the lip from another anatomic site.


Posterior Tongue Neoplasm

A benign or malignant neoplasm that affects the base of the tongue.


Benign neoplasm of base of tongue

A non-metastasizing neoplasm that arises from the base of the tongue.


Ameloblastic fibrodentinoma

A rare neoplasm arising from tooth-forming tissues. It usually arises from the posterior mandible. It is characterized by the presence of an epithelial component, fibromyxoid stroma, and dentin formation. It is treated with enucleation and curettage. Recurrences may occur.


Basal Cell Ameloblastoma

A solid/multicystic ameloblastoma with follicular pattern in which the odontogenic epithelial islands are composed of uniform basaloid cells.


Non-Neoplastic Paranasal Sinus Disorder

A non-neoplastic disorder that affects the paranasal sinuses.  Representative examples include sinusitis and mucocele.


Suppurative parotitis

Parotitis that is caused by a bacterial agent.


Sinonasal Disorder

A non-neoplastic or neoplastic disorder that affects the nasal cavity or paranasal sinuses.  Representative examples include inflammatory disorders, papillomas, and carcinomas.


Benign Maxillofacial Neoplasm

A non-metastasizing neoplasm that arises in a maxillofacial bone.


Non-Neoplastic External Ear Disorder

A non-neoplastic disorder that affects the pinna and/or the ear canal.


Pharyngeal Mucositis

An inflammatory process affecting the mucous membrane of the pharynx.


Malignant Anterior Tongue Neoplasm

A primary or metastatic malignant neoplasm that affects the anterior portion of the tongue.


Benign neoplasm of palate

A non-metastasizing neoplasm that arises from the hard palate, soft palate, or uvula.


Nasopharyngeal hairy polyp

A benign polypoid lesion that arises from the nasopharynx. It usually affects neonates and older infants. It manifests as a pedunculated mass associated with cough, dyspnea, vomiting, or difficulty in swallowing. It is composed of ectoderm and mesoderm.


Recurrent Malignant Head and Neck Neoplasm

The reemergence of a malignant head and neck neoplasm after a period of remission.


Iatrogenic Primary Hypothyroidism

Primary hypothyroidism due to medical or surgical treatment.


Leukoplakia of buccal mucosa

A clinical term that indicates the presence of a white patch on the buccal mucosa in the mouth which cannot be characterized as any other disease.  It may be a precancerous condition and in most cases histologic examination reveals keratosis.


Refractory Malignant Salivary Gland Neoplasm

A malignant salivary gland neoplasm that is resistant to treatment.