Stage III Vulvar Cancer AJCC v7

Stage III includes: IIIA: (T1/T2, N1a/N1b, M0); IIIB: (T1/T2, N2a/N2b, M0); IIIC: (T1/T2, N2c, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N1a: Vulvar cancer with one or two lymph node metastasis each measuring 5 mm or less.  N1b: Vulvar cancer with one lymph node metastasis measuring 5 mm or greater.  N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less.  N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater.  N2c: Vulvar cancer with lymph node metastasis with extracapsular spread.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent Gastroesophageal Junction Adenocarcinoma

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

The reemergence of gastroesophageal junction adenocarcinoma after a period of remission.


Grade 4 Ventricular Tachycardia, CTCAE

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

Life-threatening consequences; hemodynamic compromise


silent stroke

An asymptomatic cerebral infarction that was incidentally noted by T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensities on an MRI of the brain.


Feeding Intolerance, AE

An adverse event in a newborn characterized by inability to achieve a full feeding volume.


Refractory Acute Myelomonocytic Leukemia

Acute myelomonocytic leukemia that does not respond to treatment.


Grade 3 Thrombosis or Embolism Vascular Access Related, CTCAE


Grade 3 GGT Increased, CTCAE

>5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


Postpartum Obstetric Septic Embolism

Presence of bacterially-infected tissue in the maternal vascular system which originated from a distant site during the postpartum period.


Disabling Adverse Event

An adverse event, and/or its immediate sequelae which is associated with physical or mental disabilities that affect or limit the ability of a person to perform activities of daily living (eating, ambulation, toileting, etc.).


Human Papillomavirus-Related Verrucous Carcinoma

A verrucous carcinoma that is associated with human papilloma virus (HPV) infection.


Stage IV Acral Lentiginous Melanoma AJCC v6 and v7

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


Decreased CYBB Expression

An indication that the expression of CYBB is lower than the normal range of values.


Neonatal Adverse Event

Findings suggesting an adverse event in a neonate or newborn.


Grade 3 Cardiac Troponin I Increased, CTCAE

Levels consistent with myocardial infarction as defined by the manufacturer


Uterine Corpus Cancer by AJCC v6 Stage

A term that refers to the staging of uterine corpus cancer according to the American Joint Committee on Cancer, 6th edition.


Grade 2 Oral Intra-Operative Injury, CTCAE


Non-Metastatic Gestational Trophoblastic Tumor

Gestational trophoblastic tumor that is confined to the site in which it initially manifested.


Preseptal cellulitis

An acute infection of the anterior portion of the eyelid and surrounding tissues.


Injury of phrenic nerve

Damage to the phrenic nerve.


Non-Neoplastic Endocrine Disorder

A non-neoplastic disorder that affects the endocrine system.  Representative examples include diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency.


Grade 1 Otitis Middle Ear Non Infectious, CTCAE


Uterine Corpus Non-Neoplastic Disorder

A non-neoplastic disorder that affects the uterine corpus. Representative examples include endometritis and uterine adenomyosis.


Bone Tumor of Undefined Neoplastic Nature

A group of lesions that affect the bone and have the appearance and cytogenetic or molecular characteristics of neoplasms but the clinical behavior is suggestive of a non-neoplastic process.


Unresectable Neuroendocrine Tumor G1

Carcinoid tumor that is not amenable to surgical resection.


Metastatic Microsatellite Stable Endometrial Carcinoma

Microsatellite stable endometrial carcinoma that has spread from its original site of growth to another anatomic site.


Borderline Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder


Late Effects Severity Grade

A severity grade assigned to the late effects.


Grade 3 Ataxia, CTCAE

Severe symptoms; limiting self care ADL; mechanical assistance indicated


Grade 4 Pancreas Exocrine Enzyme Deficiency, CTCAE


Pelvic Floor Muscle Weakness, CTCAE

A disorder characterized by a reduction in the strength of the muscles of the pelvic floor.


Childhood Acute Promyelocytic Leukemia with PML-RARA

An acute promyelocytic leukemia with PML-RARA fusion occurring in children.


Grade 2 Scalp Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 3 Neonatal Hypertension, AE

An adverse event in a newborn characterized by persistent or recurrent hypertension, with systolic or diastolic blood pressure above the 99th percentile; need for antihypertensive medication.


Grade 5 Wound Dehiscence, CTCAE

Death


Metastatic osteosarcoma

An osteosarcoma which has spread to another anatomical site.


Stage IB Cutaneous Melanoma AJCC v7

Stage IB includes: (T1b, N0, M0); (T2a, N0, M0).  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Tissue or Organ Disruption

A loss of structural integrity within a tissue or organ.


Grade 3 Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


Recurrent Childhood Hodgkin Lymphoma

The reemergence of Hodgkin lymphoma after a period of remission during childhood.


Grade 2 Cerebral Artery Intra-Operative Injury, CTCAE


Iris vascular disorder

A vascular disorder or the iris.


Refractory Severe Aplastic Anemia

Severe aplastic anemia that is resistant to treatment.


Anal Sphincter Intra-Operative Injury, CTCAE


Stage IIIA Fallopian Tube Cancer AJCC v7

Stage IIIA includes: T3a, N0, M0.  T3a: Microscopic peritoneal metastasis outside the pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Pancreatic Intraductal Tubulopapillary Neoplasm with an Associated Invasive Carcinoma

A pancreatic intraductal tubulopapillary neoplasm characterized by the presence of an invasive carcinomatous component.  The invasive carcinoma has a tubular pattern.


Grade 5 Breast Infection, CTCAE

Death


Non-Infectious Gastroenterocolitis

An inflammatory disease of the stomach and intestines due to a non-infectious cause.


Adult Intracranial Meningioma

An intracranial meningioma that occurs during adulthood.


Grade 3 Pancreatic Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Grade 2 Epstein-Barr Virus Infection Reactivation, CTCAE

Moderate symptoms; medical intervention indicated


Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8

Stage III includes: IIIA: (T0-2, N1, M0); IIIB: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Non-Neoplastic Vascular Disorder

A term that includes all non-neoplastic vascular disorders.


Grade 1 Wound Complication, CTCAE

Observation only; topical intervention indicated


Grade 5 Rectal Mucositis, CTCAE

Death


Stage III Childhood Large Cell Lymphoma

Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Postneoadjuvant Therapy Stage IV Esophageal Adenocarcinoma AJCC v8

Stage IV includes: IVA: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Pancreatic Cancer by AJCC v6 and v7 Stage

A term that refers to the staging of exocrine and endocrine pancreatic cancer including well-differentiated neuroendocrine tumors according to the American Joint Committee on Cancer, 6th and 7th editions.


Recurrent Childhood Ependymoma

The reemergence of ependymoma in childhood after a period of remission.


Grade 5 Reproductive System and Breast Disorders - Other, Specify, CTCAE

Death


Vein Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Cranial Nerve II Neuropathy, CTCAE


Grade 2 Myocarditis, CTCAE

Symptoms with moderate activity or exertion


Grade 5 Sleep Apnea, CTCAE

Death


Cardiac Mesenchymal Hamartoma

A benign soft tissue mass that involves the endocardium, myocardium, or epicardium. It is characterized by the presence of an admixture of mature mesenchymal tissues normally found within the heart.


Grade 2 Mediastinum Intra-Operative Injury, CTCAE


Resectable Malignant Bone Neoplasm

Malignant bone neoplasm that is amenable to surgical resection.


Grade 3 Fungemia, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated


Grade 2 Floaters, CTCAE

Limiting instrumental ADL


Stage IA Gastric Carcinoma

Stage IA includes: T1, N0, M0.  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 1 Keratitis, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Conduction Disorder, CTCAE

Mild symptoms; intervention not indicated


Vasovagal Reaction, CTCAE

A disorder characterized by a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve.


Biliary Adenofibroma

A rare benign neoplasm that arises from the intrahepatic bile ducts.  It is characterized by the presence of biliary epithelial tissue and fibroblastic stroma.


Grade 2 Gastrointestinal Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 1 Nose Intra-Operative Injury, CTCAE


Recurrent Acute Leukemia of Ambiguous Lineage

The reemergence of acute leukemia of ambiguous lineage after a period of remission.


Metastatic Intracranial Malignant Neoplasm

An intracranial malignant neoplasm that has spread from its original site of growth to another anatomic site.


Adverse Event Attribution to Product or Procedure

A specific identifiable level (defined qualitatively or quantitatively) of probability of adverse event being caused or associated with the product or procedure administration to a patient.


Distantly Metastatic Malignant Neoplasm

A malignant tumor that has spread from its original (primary) site of growth to another site distant from the primary site.


Grade 2 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Iatrogenic Obesity

Obesity resulting from medical treatment or intervention.


Immunosuppressive Disorder

A disorder in which immune function is suppressed.


Rare Childhood Malignant Neoplasm

An infrequent malignant neoplasm that occurs during childhood.


Advanced Biliary Tract Carcinoma

Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread extensively to other anatomic sites or is no longer responding to treatment.


FNCLCC Sarcoma Grade 2

A sarcoma with a total score of 4 or 5 according to the FNCLCC guidelines.


Gynecomastia, CTCAE 5.0

A disorder characterized by excessive development of the breasts in males.


Thyroid-Binding Globulin Deficiency

Subnormal concentration of thyroid-binding globulin.


Malignant melanoma in precancerous melanosis

A melanoma arising from an atypical intraepithelial melanocytic hyperplasia.


Grade 3 Urinary Tract Obstruction, CTCAE

Altered organ function (e.g., hydronephrosis or renal dysfunction); invasive intervention indicated


Malignant Neoplasm with Regional Lymph Node Involvement

A malignant neoplasm that has spread to nearby lymph nodes.


Stage I Esophageal Cancer AJCC v7

Stage I includes: For squamous cell carcinoma: IA (T1, N0, M0, G1, GX, Tumor location: Any); IB (T1, N0, M0, G2-3, Tumor location: Any); (T2-3, N0, M0, G1, GX, Tumor location: Lower, X).  For adenocarcinoma: IA (T1, N0, M0, G1-2, X); IB (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Recurrent Childhood Astrocytic Tumor

The reemergence of a childhood astrocytic tumor after a period of remission.


Skin Squamous Cell Carcinoma with Osteoclast-Like Giant Cells

A rare squamous cell carcinoma of the skin characterized by the presence of multinucleated non-neoplastic giant cells that resemble osteoclasts.


Grade 1 Chills, CTCAE

Mild sensation of cold; shivering; chattering of teeth


Grade 1 Hematoma, CTCAE

Mild symptoms; intervention not indicated


Grade 2 Anus Stricture or Stenosis, CTCAE


Job Strain

Negative physical or emotional health outcomes resulting from high job demands with low job decision latitude.


Stage IA Uterine Corpus Cancer AJCC v7

Stage IA includes: T1a, N0, M0.  T1a: Tumor limited to the endometrium or invades less than one-half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Grade 1 Cardiac Ischemia or Infarction, CTCAE


Grade 5 Atrial Fibrillation, CTCAE

Death


Grade 5 Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Methemoglobinemia, CTCAE

Requiring urgent intervention


Tooth Development Disorder, CTCAE

A disorder characterized by a pathological process of the teeth occurring during tooth development.


Hodgkin's disease mixed cellularity stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Syncope, CTCAE

Fainting; orthostatic collapse


Other Pulmonary and Upper Respiratory, CTCAE


Grade 2 Pulmonary Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 5 Venous Injury, CTCAE

Death


Early Rheumatoid Arthritis

Recent diagnosis of rheumatoid arthritis (usually within one to two years of onset) during which treatment may be more effective and possibly improve the disease course.


Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Genitourinary Stoma Hemorrhage, CTCAE


Grade 5 Colonic Stenosis, CTCAE

Death


Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 1 Ischemia Cerebrovascular, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Appendix Intra-Operative Injury, CTCAE


Grade 4 Duodenal Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Astler-Coller A Rectal Carcinoma

Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.)


Grade 4 Cranial Nerve II Intra-Operative Injury, CTCAE


Grade 5 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Atrioventricular Block Complete, CTCAE

Non-urgent intervention indicated


Grade 3 Small Bowel Obstruction NOS, CTCAE


Condyloma acuminata of cervix

A benign neoplasm that arises from the cervix. It is associated with human papillomavirus infection and is characterized by the presence of papillary structures with fibrovascular cores. The papillary structures are covered with stratified squamous epithelium. Koilocytosis is usually present.


Grade 5 Cardiac Ischemia or Infarction, CTCAE


Locally Advanced Urethral Urothelial Carcinoma

A urethral urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 1 Constipation, CTCAE

Occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema


Stage I Bone Sarcoma AJCC v7

Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 3 Watering Eyes, CTCAE

Marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200)


Grade 1 Venous Injury, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Bacterial prostatitis

An acute or chronic bacterial infection that affects the prostate gland.


Grade 5 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Biliary Tree Stricture or Stenosis, CTCAE


Grade 3 Ligament Intra-Operative Injury, CTCAE


Grade 4 Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IIIA2 Fallopian Tube Cancer AJCC v8

Stage IIIA2 includes: T3a, N0/N1, M0. T3a: T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Generalized morphea

A type of morphea characterized by four or more plaques found in two or more anatomic locations. The plaques are indurated, generally well-delineated, and may include muscle atrophy in affected areas; there is no visceral involvement.


Grade 2 Cranial Nerve V Motor Intra-Operative Injury, CTCAE


Grade 5 Colon or Cecum or Appendix Necrosis, CTCAE


Grade 3 Agitation, CTCAE

Severe agitation; hospitalization not indicated


Grade 4 Metabolic or Respiratory Alkalosis, CTCAE


Grade 4 Thyroid Intra-Operative Injury, CTCAE


Vinyl Chloride or Derivatives Exposure

Environmental, occupational, or consumer-based exposure to vinyl chloride or its derivatives during the manufacture or breakdown of polyvinyl chloride (PVC) and other vinyl containing products.


Congenital, Familial and Genetic Disorders, CTCAE


Grade 2 Urethra Intra-Operative Injury, CTCAE


Grade 3 Postoperative Thoracic Procedure Complication, CTCAE

Extubated >72 hrs postoperatively, but before tracheostomy indicated


Pathological dislocation of joint

A joint dislocation not due to trauma.


Grade 2 Esophageal Ulcer, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Libido Decreased, CTCAE

A disorder characterized by a decrease in sexual desire.


Grade 3 Pulmonary Fistula, CTCAE

Invasive intervention indicated


T-Cell Proliferation of Uncertain Malignant Potential

A T-cell lymphoproliferative disorder with uncertain malignant potential. A representative example is lymphomatoid papulosis.


Grade 2 Injury To Carotid Artery, CTCAE

Repair or revision not indicated


Grade 1 Neuroendocrine Growth Hormone Secretion Abnormality, CTCAE


Sclerosing peritonitis

A rare peritoneal cavity disorder that is characterized by the development of dense fibrous tissue in the peritoneum and the creation of severe adhesions in the abdomen that result in partial or complete small bowel obstruction. It may be idiopathic or develop in patients who receive peritoneal dialysis treatment. Patients present with abdominal distention and pain.


Grade 2 Lymphocele, CTCAE

Symptomatic; medical intervention indicated


COVID-19 Rash

A change in the appearance or texture of the skin that is associated with SARS-CoV-2 infection (COVID-19).


Grade 5 Uterus Stricture or Stenosis, CTCAE


Grade 2 Vas Deferens Anastomotic Leak, CTCAE


Ocular Foreign Body

External material that enters the eye.


B-Cell Lymphoproliferative Disorder

A non-neoplastic or neoplastic proliferation of B-lymphocytes.


Gallbladder Cancer by AJCC v6 Stage

A term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 6th edition.


Stage IV Gallbladder Cancer AJCC v7

Stage IV includes: IVA (T4, N0-1, M0); IVB (Any T, N2, M0); (Any T, Any N, M1).  T4: Tumor invades the main portal vein or hepatic artery, or invades two or more extrahepatic organs or structures.  N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis. (from AJCC 7th Ed.)


Monogenic Obesity

Obesity associated with an identifiable mutation in a single gene.


Fibrocartilaginous Mesenchymoma

A very rare, locally aggressive neoplasm arising from the bones, usually from the metaphysis of long tubular bones. It is composed of spindle cells, hyaline cartilage nodules, and trabeculae of bone. It may recur locally, but no metastases have been reported.


Stage II Cervical Cancer FIGO 2009

Cervical carcinoma invading beyond the uterus but not extending onto the lower third of the vagina or to the pelvic wall. (FIGO 2009)


Grade 2 Rectum Intra-Operative Injury, CTCAE


Grade 4 Pharynx Obstruction and Stenosis, CTCAE


Chest Pain Along Right Midclavicular Line

The location of the chest pain is along the right midclavicular line.


Grade 1 Pruritus, CTCAE

Mild or localized; topical intervention indicated


Human Papillomavirus-Independent Vulvar Squamous Cell Carcinoma

Vulvar squamous cell carcinoma not associated with human papillomavirus infection.


Grade 3 Psychosis Including Hallucinations and Delusions, CTCAE


Grade 2 Esophageal Stenosis, CTCAE

Symptomatic; altered GI function


Stage III Carcinoma of Stomach

Stage III includes: IIIA (T2a/b, N2, M0); (T3, N1, M0); (T4, N0, M0).  IIIB: (T3, N2, M0).  N0: No regional lymph node metastasis. N1: Metastasis in 1 to 6 regional lymph nodes.  N2: Metastasis in 7 to 15 regional lymph nodes. T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa. T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. T4: Tumor invades adjacent structures.  M0: No distant metastasis. (AJCC 6th ed.)


Grade 2 Penile Pain, CTCAE

Moderate pain; limiting instrumental ADL


Refractory Anal Carcinoma

Anal carcinoma that does not respond to treatment.


Nasal Congestion, CTCAE

A disorder characterized by obstruction of the nasal passage due to mucosal edema.


Refractory Malignant Female Reproductive System Neoplasm

Malignant female reproductive system neoplasm that is resistant to treatment.


Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Anal Fistula, CTCAE

Asymptomatic


Grade 5 Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage II Gallbladder Cancer AJCC v8

Stage II includes: IIA: T2a, N0, M0; IIB: T2b, N0, M0. T2a: Tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum). T2b: Tumor invading the perimuscular connective tissue on the hepatic side, with no extension into the liver. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Abdomen NOS Intra-Operative Injury, CTCAE


Ampullary Noninvasive Papillary Neoplasm, Pancreatobiliary Type

An exophytic, preinvasive, papillary epithelial neoplasm that arises from the ampulla of Vater.  Histologically it resembles the papillary neoplasms of the biliary tree.  This category includes neoplasms with low grade dysplasia and high grade dysplasia.


Grade 1 Nervous System Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 2 Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Lung Thoracic Nerve Intra-Operative Injury, CTCAE


Stage IVA Uterine Corpus Cancer AJCC v7

Stage IVA includes: T4, Any N, M0. T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Somnolence and Depressed Level of Consciousness, CTCAE


Drug Resistant Bacterial Infection

A bacterial infection that is resistant to antibiotics and antimicrobials.


Metastatic Pancreatic Neuroendocrine Carcinoma

Pancreatic neuroendocrine carcinoma that has spread from the original site of growth to another anatomic site.


Infective Phlebitis

Infection at the site of needle puncture or intravenous catheter placement due to poor aseptic techniques. It is characterized by erythema, pain, swelling, and induration at the catheter insertion site.


Grade 3 Premature Delivery, CTCAE

Delivery of a liveborn infant at 24 to 28 weeks gestation


Grade 3 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Bacterial tracheitis

Bacterial infectious process with formation of mucopurulent membranes affecting the trachea. Causative agents include Staphylococcus, Streptococcus, Haemophilus influenzae, Pseudomonas, and Klebsiella.


Grade 5 Vas Deferens Stricture or Stenosis, CTCAE


Urinary Retention, CTCAE

A disorder characterized by accumulation of urine within the bladder because of the inability to urinate.


Nystagmus, CTCAE 5.0

A disorder characterized by involuntary movements of the eyeballs.


Grade 3 Bone Intra-Operative Injury, CTCAE


Intermediate Grade Adult Non-Hodgkin's Lymphoma


Grade 1 Postnasal Drip, CTCAE

Mild symptoms; intervention not indicated


Grade 2 Hemoglobin Increased, CTCAE

Increase in >2-4 g/dL


Pre-Existing Organ Dysfunction

Organ dysfunction that was present prior to evaluation.


Atypical Endometriosis

A precancerous lesion characterized by the presence of atypical glandular epithelial features in foci of endometriosis. Atypical endometriosis has been observed in contiguity with carcinomas.


Grade 4 Ileal Hemorrhage, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage III Pancreatic Neuroendocrine Tumor AJCC v8

Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor invading adjacent organs (stomach, spleen, colon, adrenal gland) or the wall of large vessels (celiac axis or the superior mesenteric artery). N0: No regional lymph node involvement. N1: Regional lymph node involvement. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Sarcoma with BCOR genetic alterations

A group of rare primitive round cell sarcomas characterized by the presence of BCOR genetic alterations. This category includes sarcomas with BCOR-related gene fusions, most frequently BCOR-CCNB3, and sarcomas showing internal tandem duplication (BCOR-ITD).


Stage IV Low-CSD Melanoma AJCC v7

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


Grade 2 Vagus Nerve Disorder, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 5 Radiculitis, CTCAE

Death


Microsatellite Stable Endometrial Carcinoma

Endometrial carcinoma characterized by the absence of microsatellite instability.


Human Papillomavirus-Related Vulvar Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the vulva and is caused by human papillomavirus infection.


Non-Neoplastic Eyelid Disorder

A non-neoplastic disorder that affects the eyelid.


carcinoma of lacrimal apparatus

A carcinoma that arises from the lacrimal gland or the lacrimal drainage system.


Grade 2 Gastric Stenosis, CTCAE

Symptomatic; altered GI function


Prostate Adenocarcinoma with Paneth Cell-Like Neuroendocrine Differentiation

A prostate adenocarcinoma characterized by the presence of cells with eosinophilic cytoplasmic granules that are positive for neuroendocrine markers by immunohistochemistry.


Grade 1 Urinary Incontinence, CTCAE

Occasional (e.g., with coughing, sneezing, etc.), pads not indicated


Mediastinal Cyst

A fluid-filled, epithelium-lined cyst located in the mediastinum.


Grade 4 Blood and Lymphatic System Disorders - Other, Specify, CTCAE


Increased Peak Drug Blood Concentration

Increased maximum (peak) concentration of a drug observed after its administration.


Stage IV Hodgkin Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Grade 4 Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


Osteolytic Neoplasm

A neoplasm that involves bone destruction.


Clinical Stage IB Cutaneous Melanoma AJCC v8

Stage IB includes: (T1b, N0, M0); (T2a, N0, M0). T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Recurrent Malignant Neoplasm

The reemergence of a malignant neoplasm after a period of remission.


Umbilical Vasculitis

A neutrophilic infiltrate arising from fetal vessels of the umbilical cord into the umbilical vessel wall and oriented towards the amniotic cavity.


Grade 3 Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Unresectable Paratesticular Malignant Mesothelioma

Paratesticular malignant mesothelioma that is not amenable to surgical resection.


Dialysis Catheter Exit Site Infection

Local infection at the dialysis catheter exit site.


Giant Cell Epulis

A reactive localized proliferation of mononuclear cells and osteoclast-type giant cells in a vascular stroma outside bone. It occurs in the gingiva or alveolar mucosa. (WHO 2017)


Central Nervous System Carcinoma

A malignant tumor arising in the epithelial cells of the brain or spinal cord.


Grade 3 Associated with Dentures or Dental Prosthesis, CTCAE


Vaginal cancer recurrent

The reemergence of vaginal carcinoma after a period of remission.


signet ring cell carcinoma of appendix

An adenocarcinoma arising from the appendix, characterized by the presence of signet-ring, mucin-producing malignant cells.  The signet-ring cells constitute more than fifty-percent of the malignant cells.


Refractory Acute Biphenotypic Leukemia

Acute biphenotypic leukemia that is resistant to treatment.


Grade 5 Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Otitis Media, CTCAE

Death


Grade 2 Cranial Nerve III Intra-Operative Injury, CTCAE


Grade 2 Herpes Simplex Reactivation, CTCAE

Moderate symptoms; medical intervention indicated


Genital Tract Fistula

An abnormal communication between the genital tract and another organ or anatomic structure.


Grade 2 Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


Grade 1 Psychiatric Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 5 Fallopian Tube Stricture or Stenosis, CTCAE


Recurrent Primary Myelofibrosis

The reemergence of primary myelofibrosis after a period of remission.


Grade 3 Prostatic Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


Left Ventricular Systolic Dysfunction, CTCAE 3.0

Defined in terms of ejection fraction, a good clinical indicator of ventricular systolic function. Normal ejection fraction is 0.50 or more (>50%). Left ventricular systolic dysfunction is generally defined as an ejection fraction equal to or less than 0.40 (<40%).


Grade 2 Larynx Intra-Operative Injury, CTCAE


Borderline Fallopian Tube Mucinous Tumor

A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by an atypical proliferation of mucinous-type epithelial cells without evidence of stromal invasion.


Grade 4 Apnea, CTCAE

Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Mucous Membrane Hemangioma

A hemangioma arising from the mucous membranes.


Grade 2 Retinal Tear, CTCAE

No retinal detachment and treatment indicated


Grade 1 Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


Aortic Valve Disease, CTCAE

A disorder characterized by a defect in aortic valve function or structure.


Grade 4 Serum Hypertriglyceridemia, CTCAE


Adenocarcinoma with apocrine metaplasia

An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to cells with abundant, usually granular eosinophilic cytoplasm.


Gastroesophageal Reflux Disease, CTCAE

A disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is chronic in nature and usually caused by incompetence of the lower esophageal sphincter, and may result in injury to the esophageal mucosal. Symptoms include heartburn and acid indigestion.


Bladder Neurofibroma

A plexiform or diffuse neurofibroma arising from the bladder.


Stage IB Esophageal Adenocarcinoma AJCC v7

Stage IB includes: (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Grade 4 Epstein-Barr Virus Infection Reactivation, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Phantom Pain Associated with Missing Limb, CTCAE


Grade 3 Injury To Jugular Vein, CTCAE

Symptomatic limiting self care ADL; repair or revision indicated


Grade 3 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Locally Advanced Paraganglioma

A paraganglioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Constipation, CTCAE

Death


Grade 5 Retroperitoneum Hemorrhage, CTCAE


Grade 5 Duodenum Stricture or Stenosis, CTCAE


Thymic Damage

Anatomic injury or physiologic dysfunction of the thymus gland.


Hyperactive Chest Appearance

Inspection of the region of the anterior surface of the chest and epigastrium reveals a highly or excessively active or hyperkinetic apical impulse.


Early Stage Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma that has not spread beyond the pancreas.


Enzyme Deficiency

A finding in which there is a subnormal amount of an enzyme. Enzymes are proteins that are necessary in certain catabolic processes.


Recurrent Primary Malignant Neoplasm

The reemergence of a primary malignant neoplasm after a period of remission.


Grade 4 Retroperitoneum Hemorrhage, CTCAE


Chest Pain in Upper Sternum

The location of the chest pain is in the upper portion of the sternum.


Grade 3 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Gingival Pain, CTCAE

Mild pain


regressing melanoma of skin

Cutaneous melanoma characterized by the disappearance of the melanoma cells from the primary tumor.


Grade 2 Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Metastatic Digestive System Carcinoma

A digestive system carcinoma that has metastasized to another anatomic site and is resistant to treatment.


Lymphoepithelial tumor of skin

A rare, poorly differentiated squamous cell carcinoma of the skin. It is characterized by the presence of tumor cells islands surrounded and infiltrated by lymphocytes and plasma cells.


Grade 5 Lower Extremity Soft Tissue Necrosis, CTCAE


Advanced Primary Malignant Central Nervous System Neoplasm

A malignant neoplasm that arises from the central nervous system and has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Electrocardiogram QT Corrected Interval Prolonged, CTCAE

Average QTc 481-500 ms


Stage II Bone Cancer AJCC v8

Stage II includes: IIA: (T1, N0, M0, G2 or G3); IIB: (T2, N0, M0, G2 or G3). T1: Tumor measuring 8 cm or less in greatest dimension. T2: Tumor measuring more than 8 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Oral Verruca Vulgaris

Verruca vulgaris in the lips and oral cavity.


Pathologic Stage II Merkel Cell Carcinoma AJCC v8

Stage II includes: IIA: (T2-3, N0, M0); IIB: (T4, N0, M0). T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Grade 4 Dermatitis Radiation, CTCAE

Life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated


Refractory Human Papillomavirus-Related Malignant Neoplasm

Human papillomavirus-related malignant neoplasm that does not respond to treatment.


Grade 2 Neonatal Hypotension, AE

An adverse event in a newborn characterized by persistent (greater than 60 minutes) hypotension; not affecting perfusion; requiring minor care changes (e.g. additional fluids).


Epstein-Barr Virus Infection Reactivation, CTCAE

A disorder characterized by the reactivation of Epstein-Barr virus (EBV).


Implant Pain

Pain localized to the site of the implanted device.


Grade 4 Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Cecum Intra-Operative Injury, CTCAE


Lymph Node Mass

A benign or malignant solid pathologic process involving a lymph node.


Mental Status, CTCAE

An adverse event resulting in a change in a patient's intellectual capacity, emotional state, or general mental health.


Steroidogenic Acute Regulatory Protein Deficiency

Congenital lipoid adrenal hyperplasia (CLAH) due to loss-of-function mutations in the STAR gene, resulting in decreased or absent production of steroidogenic acute regulatory protein (StAR), which leads to deficient transport of cholesterol from the outer to the inner mitochondrial membrane.


Grade 2 Sinusitis, CTCAE

Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Uterine Corpus Cancer by AJCC v8 Stage

A term that refers to the staging of uterine corpus cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to uterine corpus sarcomas: leiomyosarcomas, endometrial stromal sarcomas, and adenosarcomas. These sarcomas are staged according to the classification for uterine corpus sarcomas. (from AJCC 8th Ed.)


Adult Pure Erythroid Leukemia

A pure erythroid leukemia occurring in adults.


Grade 3 Ureteric Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 2 Salivary Gland or Saliva Changes, CTCAE


Endometrioid carcinoma of prostate

A usually aggressive invasive adenocarcinoma of the prostate gland composed of large glands containing tall columnar cells.  The columnar cells have abundant cytoplasm and are reminiscent of endometrial carcinoma.  This type of adenocarcinoma has a tendency to metastasize to the lung and penis.


Grade 2 Ureter Stricture or Stenosis, CTCAE


Cardiac Arrest, CTCAE

A disorder characterized by cessation of the pumping function of the heart.


Grade 5 Spinal Cord Compression, CTCAE

Death


Bone Infection, CTCAE

A disorder characterized by an infectious process involving the bones.


Grade 1 Inner Ear Intra-Operative Injury, CTCAE


Grade 1 Cecum or Appendix Hemorrhage, CTCAE


Colonic Ulcer, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the colon.


Stage IVA Bladder Cancer AJCC v8

Stage IVA includes: (T4b, N0, M0); (Any T, Any N, M1a). T4b: Extravesical tumor invades pelvic wall, abdominal wall. N0: No regional lymph node metastasis. M0: No distant metastasis. M1a: Distant metastasis limited to lymph nodes beyond the common iliacs. (AJCC 8th ed.)


Grade 4 Gastrointestinal Stoma Leak, CTCAE


Grade 1 Middle Ear Intra-Operative Injury, CTCAE


Uterine Fistula

An abnormal communication between the uterus and another organ.


Grade 5 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


Metastatic malignant neoplasm to urinary system

A malignant neoplasm that has spread to the urinary system from another anatomic site.


Grade 2 Ileum Infection with Unknown Absolute Neutrophil Count, CTCAE


Nevus spider congenital

A type of telangiectasia, comprised of a central red spot with radiating, red extensions, that is present at the time of birth.


Polyp Tip

The distal end of a polyp.


Grade 5 Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Lugano Classification Adult Hodgkin Lymphoma by AJCC v8 Stage

A staging system for adult Hodgkin lymphomas based on the Lugano classification criteria. Staging for adult Hodgkin lymphoma is the same as for the childhood counterpart. (from AJCC 8th Ed.)


Grade 2 Tracheitis, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Osteoclast-Rich Osteopetrosis

A form of osteopetrosis in which osteoclasts are abundant but have severely impaired resorptive function.


Esophageal Infection, CTCAE

A disorder characterized by an infectious process involving the esophagus.


Stage II Renal Pelvis and Ureter Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Serum Glutamic Oxaloacetic Transaminase, CTCAE


Recurrent Fallopian Tube Adenocarcinoma

The reemergence of fallopian tube adenocarcinoma after a period of remission.


Grade 4 Intraoperative Endocrine Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Bulky Mediastinal Mass

When the maximum width of a mass is equal or greater than one-third of the internal transverse diameter of the thorax at the level of T5/6 on a PA CXR. Bulk at an alternate site is defined as any mass measuring 10 cm or more by any imaging study.


Grade 4 Sciatic Nerve Intra-Operative Injury, CTCAE


Gum Infection

An acute or chronic infectious process affecting the gums.


Grade 2 Pericarditis, CTCAE

Symptomatic pericarditis (e.g., chest pain)


Inflammatory fibroepithelial hyperplasia of oral mucous membrane caused by denture

A benign fibrous hyperplasia in the oral mucosa caused by the prolonged wear of ill-fitting denture.


Grade 1 Gastric Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 4 Creatinine Increased, CTCAE

>6.0 x ULN


Grade 2 Anal Pain, CTCAE

Moderate pain; limiting instrumental ADL


Amegakaryocytosis

A non-neoplastic, congenital or non-congenital disorder charcaterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Grade 3 Aorta Artery Intra-Operative Injury, CTCAE


Grade 1 Neuroendocrine ACTH Deficiency, CTCAE


PSA Level Equal to Nadir Plus 2 ng/mL

A finding indicating that the blood concentration of prostate specific antigen in a subject's sample has increased by 2 ng/mL over the lowest value recorded for a sample from that subject.


Grade 5 Arterial Injury, CTCAE

Death


Grade 3 External Ear Pain, CTCAE

Severe pain; limiting self care ADL


Grade 1 Bronchial Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Lugano Classification Stage II Adult Lymphoma AJCC v8

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Lacrimal Gland Epithelial-Myoepithelial Carcinoma

A rare, slow-growing carcinoma that arises from the lacrimal gland. It is characterized by the presence of duct-like structures lined by two layers of cells, an inner layer composed of epithelial-type cells and an outer layer composed of clear, myoepithelial-type cells.


Grade 1 Papilledema, CTCAE

Asymptomatic; no visual field deficit


FIGO Stage IA Gestational Trophoblastic Tumor


Grade 2 Urinary Tract Obstruction, CTCAE

Symptomatic but no hydronephrosis, sepsis, or renal dysfunction; urethral dilation, urinary or suprapubic catheter indicated


Increased Concomitant Drug Peak Blood Concentration

Increased maximum (peak) concentration of a concomitant drug observed after its administration.


Testicular Neuroendocrine Tumor G1

A rare well differentiated neuroendocrine  tumor (carcinoid tumor) that arises from the testis.


Adult Pre-B Acute Lymphoblastic Leukemia

Pre-B acute lymphoblastic leukemia that occurs during adulthood.


Grade 4 Bronchial Obstruction, CTCAE

Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Dedifferentiated liposarcoma that is not amenable to surgical resection.


Stage IVA Vulvar Cancer AJCC v6

Stage IVA includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0).  N2: Bilateral regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IV Cervical Cancer FIGO 2009

Cervical carcinoma involving adjacent and distant organs. (FIGO 2009)


Abnormal Blood Gas Measurement

Arterial blood gas test results that are outside normal limits.


Secondary hemochromatosis

Hemochromatosis that is not inherited and is caused by iron overload from excessive consumption, multiple transfusions, or disorders of erythropoiesis.


Subarachnoid hematoma

A collection of blood into the space between the pia membrane and arachnoid membrane.


Astler-Coller C1 Rectal Carcinoma

Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.)


Stage IIIA Digestive System Neuroendocrine Tumor AJCC v7

Stage IIIA includes: T4, N0, M0.  T4: Stomach/duodenum/ampulla/jejunum/ileum: tumor invades visceral peritoneum (serosa) or invades other organs or adjacent structures; colon or rectum: tumor invades peritoneum or other organs.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 4 Chronic Kidney Disease, CTCAE

eGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated


Cataract associated with radiation

A cataract resulting from exposure to radiation.


Intermediary Metabolism Disorder

An inborn metabolic disorder affecting the intermediary metabolism process. It results in accumulation of substances in the body that can cause acute or chronic intoxication.


Adverse effects

The term was used in various ways in the past, to describe unintended effects of medical intervention, usually negative (unfavourable), but also positive (favourable) ones. It is recommended that this term no longer be used and particularly should not be regarded as synonymous with adverse event or adverse reaction.


Grade 1 Cystitis Noninfective, CTCAE

Microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence


Grade 4 Neonatal Sinus Tachycardia, AE

A sinus tachycardia adverse event in a newborn characterized by life-threatening consequences; requiring urgent major care changes.


Childhood Pilomyxoid Astrocytoma

A pilomyxoid astrocytoma that occurs during childhood.


Grade 3 Vulva Intra-Operative Injury, CTCAE


Intraoperative Hepatobiliary Injury, CTCAE

A finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure.


Grade 4 Catheter Related Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Forced Expiratory Volume Decreased, CTCAE

FEV1% (percentages of observed FEV1 and FVC related to their respective predicted values) 99-70% predicted


Grade 3 Nodal or Junctional Rhythm, CTCAE


Grade 1 Vaccination Site Lymphadenopathy, CTCAE

Local lymph node enlargement


Advanced Hodgkin Lymphoma

Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Non-Neoplastic Peritoneal and Retroperitoneal Disorder

A non-neoplastic disorder that affects the peritoneum and/or retroperitoneum.


Grade 4 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Fetal Chorionic Vasculitis

A neutrophilic infiltrate arising from fetal vessels in the chorionic plate and oriented towards the amniotic cavity.


Low Calcium Level

A lower than average level of calcium in a sample.


Chest Pain Along Left Upper Sternal Border

The location of the chest pain is along the left upper border of the sternum.


Small Intestinal Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the small intestine.


Merkel Cell Carcinoma by AJCC v8 Stage

A term that refers to the staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


Grade 1 Other Hepatobiliary and Pancreas, CTCAE


Grade 3 Peripheral Sensory Neuropathy, CTCAE

Severe symptoms; limiting self care ADL


Refractory Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction adenocarcinoma that does not respond to treatment.


Gallbladder Infection

An acute or chronic infectious process affecting the gallbladder.


Hereditary Malignant Urinary System Neoplasm

A malignant urinary system neoplasm that has developed in relatives of patients with a history of malignant urinary system neoplasm.


Catheter Related Infection, CTCAE

A disorder characterized by an infectious process that arises secondary to catheter use.


Edema of the Trunk and Genital Area, CTCAE


Neoplasm of musculoskeletal system

A benign, intermediate, or malignant neoplasm that affects muscles and bones.


Low Grade Broad Ligament Serous Adenocarcinoma

A slow-growing serous adenocarcinoma that arises from the broad ligament. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.


Grade 3 Pancreatic Endocrine Glucose Intolerance, CTCAE


Syringocystadenocarcinoma papilliferum

A sweat gland carcinoma usually arising from a pre-existing syringocystadenoma papilliferum.


Grade 2 Erythema Multiforme, CTCAE

Target lesions covering 10-30% BSA and associated with skin tenderness


Grade 4 Serum Glutamic Pyruvic Transaminase, CTCAE


Acute Myeloid Leukemia with Monoallelic Mutations of CEBPA

An acute myeloid leukemia with single mutations of the CEBPA gene.


Stage IB Cervical Cancer FIGO 2009

Cervical carcinoma measuring more than 5 mm in depth. (FIGO 2009)


Grade 1 Pharyngeal Mucositis, CTCAE

Endoscopic findings only; minimal symptoms with normal oral intake; mild pain but analgesics not indicated


Grade 1 Diarrhea, CTCAE

Increase of <4 stools per day over baseline; mild increase in ostomy output compared to baseline


Grade 3 Salivary Gland Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Vaginal Obstruction, CTCAE

Symptomatic; elective intervention indicated


Grade 5 Injury To Superior Vena Cava, CTCAE

Death


Cardiac Troponin I Increased, CTCAE

A finding based on laboratory test results that indicate increased levels of cardiac troponin I in a biological specimen.


Grade 4 Ventricular Fibrillation, CTCAE

Life-threatening consequences; hemodynamic compromise


Extrapyramidal Disorder, CTCAE

A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness.


Locally Advanced Pancreatobiliary Carcinoma

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction adenocarcinoma that has spread to nearby tissues or lymph nodes.


Spinal Cord Intra-Operative Injury, CTCAE


Grade 2 Infective Myositis, CTCAE

Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Grade 2 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Adenocarcinoma with neuroendocrine differentiation

An invasive adenocarcinoma characterized by the presence of focal or extensive neuroendocrine differentiation.


Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE


Grade 1 Uterine Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Cutaneous Langerhans cell histiocytosis

Langerhans cell histiocytosis that affects the skin. It manifests with skin papules and plaques.


Grade 4 Gingiva Intra-Operative Injury, CTCAE


Grade 1 Hepatic Artery Intra-Operative Injury, CTCAE


Phantom Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort related to a limb or an organ that is removed from or is not physically part of the body.


Grade 2 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Radiating Chest Pain Along Right Anterior Axillary Line

The location of the radiating chest pain is along the right anterior axillary line.


Grade 3 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


Grade 4 Other Hepatobiliary and Pancreas, CTCAE


Nontraumatic extradural hemorrhage

Bleeding into the epidural space that is not associated with physical trauma.


Stage I Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Gastroparesis, CTCAE

A disorder characterized by an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine.


Grade 3 Oculomotor Nerve Disorder, CTCAE

Severe symptoms; limiting self care ADL


Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


Caustic injury

Tissue corrosion or chemical burn.


Grade 4 Abdominal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Breast Adenolipoma

A breast hamartoma characterized by the presence of adipose tissue that contains entrapped glands.


Pathologic Stage IVB Esophageal Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1, Any G. M1: Distant metastasis. (AJCC 8th ed.)


Grade 2 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Uterus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Adult Acute Myeloid Leukemia with Maturation

An acute myeloid leukemia with maturation occurring in adults.


Atrial Flutter, CTCAE

A disorder characterized by a dysrhythmia with organized rhythmic atrial contractions with a rate of 200-300 beats per minute. The rhythm disturbance originates in the atria.


Grade 3 Abdomen Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Suicidal Ideation, CTCAE

Specific plan to commit suicide with serious intent to die which requires hospitalization


Tertiary Parathyroid Gland Hyperplasia

Parathyroid gland hyperplasia that results from progression of secondary hyperparathyroidism in which the parathyroid glands secrete parathyroid hormone autonomously, despite the presence of elevated parathyroid hormone and calcium levels in the serum.


Grade 5 Hematoma, CTCAE

Death


Adult Oligodendroglial Tumor

An oligodendroglial tumor of the central nervous system occurring in adults.


Grade 2 Small Bowel Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Biliary Tree Common Bile Duct Intra-Operative Injury, CTCAE


Grade 3 Colon Stricture or Stenosis, CTCAE


Grade 1 Weight Gain, CTCAE

5-<10% from baseline


Grade 5 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Sinus Tachycardia, CTCAE

Symptomatic; non-urgent medical intervention indicated


Tumor Mass

A benign or malignant pathologic structure in any part of the body, resulting from a neoplastic accumulation of cells.


Rash Acneiform, CTCAE

A disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back.


Recurrent Myelofibrosis

The reemergence of myelofibrosis after a period of remission.


Metastatic Mesonephric Adenocarcinoma

Mesonephric adenocarcinoma that has spread from its original site of growth to another anatomic site.


Grade 3 Hemolysis, CTCAE

Transfusion or medical intervention indicated (e.g., steroids)


Locally Advanced Genitourinary System Carcinoma

A genitourinary system carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Post-kala-azar dermal leishmaniasis

A cutaneous form of leishmaniasis which sometimes occurs after visceral leishmaniasis treatment.  It is characterized by hypo-pigmented macules, papules, plaques, nodules, or facial erythema; and is considered to be a durable infection reservoir for visceral leishmaniasis.


Oligoclonal Bands

The presence of more than one immunoglobulin band in the serum, urine, or cerebrospinal fluid. It usually results from infectious or immunologic disorders.


Grade 2 Pruritus, CTCAE

Widespread and intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL


Vulvar Cancer by AJCC v8 Stage

A term that refers to the staging of vulvar cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to all carcinomas of the vulva. Melanoma of the vulva is staged according to the classification for melanoma of the skin. (AJCC 8th Ed.)


Grade 3 Dental-Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Aspiration, CTCAE

Death


Grade 3 Retinopathy of Prematurity, AE

An adverse event in a newborn characterized by type 1 prethreshold retinopathy of prematurity (ROP) (zone 1 any stage with plus disease; zone 1 International Classification of Retinopathy of Prematurity (ICROP) stage 3 without plus disease; zone 2 ICROP stage 2 or 3 with plus disease); threshold ROP; requiring major care changes (e.g. laser intervention, intravitreal anti-VEGF therapy or operative management).


IgA Monoclonal Gammopathy

An abnormal laboratory test result indicating the presence of IgA monoclonal immunoglobulin in the blood or urine.


Grade 5 Encephalomyelitis Infection, CTCAE

Death


Grade 1 Bloating, CTCAE

No change in bowel function or oral intake


Abnormal Blood Antidiuretic Hormone

A laboratory test result which indicates abnormal levels of antidiuretic hormone in the blood.


Digestive System Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The Ki-67 index is higher than 20%.


Intra-Abdominal Hemorrhage, CTCAE

A disorder characterized by bleeding in the abdominal cavity.


Grade 1 Esophagus Stricture or Stenosis, CTCAE


Grade 4 Central Nervous System Hemorrhage, CTCAE


Low lying placenta

A condition in which the placental edge is within 2 cm of but not covering the cervical os.


Refractory Prostate Adenocarcinoma

Prostate adenocarcinoma that is resistant to treatment.


Grade 5 Upper Airway Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction adenocarcinoma which has spread from its original site of growth to another anatomic site.


Non dystrophic myotonia

A group of rare skeletal muscle ion-channel disorders caused by genetic mutations in the sodium and chloride channel genes. It is characterized by altered membrane excitability resulting in skeletal muscle stiffness. This group of myotonias is distinct from myotonic dystrophy because of the absence of systemic features or progressive weakness.


Traditional Serrated Adenoma

An adenoma that arises from the large intestine and the appendix.  It is characterized by prominent serration of the glands.


Acute on chronic graft-versus-host disease

Sudden decompensation of chronic graft versus host disease.


Grade 3 Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


Gallbladder Neuroendocrine Tumor G1

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the gallbladder. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Secondary malignant neoplasm of vulva

A malignant neoplasm that has spread to the vulva from another anatomic site.


Grade 3 Injection Site Reaction, CTCAE

Ulceration or necrosis; severe tissue damage; operative intervention indicated


Grade 1 Cranial Nerve IV Intra-Operative Injury, CTCAE


Grade 3 Abdomen NOS Intra-Operative Injury, CTCAE


Pharyngeal Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the pharynx.


Grade 5 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Fracture, CTCAE

Severe symptoms; displaced or open wound with bone exposure; limiting self care ADL; operative intervention indicated


Grade 3 Photophobia, CTCAE

Limiting self care ADL


Stage IA Merkel Cell Carcinoma AJCC v7

Stage IA includes: T1, pN0, M0.  T1: Primary tumor equal or less than 2 cm in size.  pN0: No regional lymph node metastasis by pathologic examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Borderline Exocrine Pancreatic Neoplasm

A group of epithelial neoplasms that arise from the exocrine pancreatic tissue and have the potential to evolve into invasive malignant neoplasms.  This group includes the pancreatic intraepithelial neoplasias, non-invasive pancreatic mucinous-cystic neoplasms, pancreatic intraductal papillary-mucinous neoplasms, and pancreatic intraductal tubulopapillary neoplasms.


Metastatic Anal Canal Squamous Cell Carcinoma

Anal canal squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


S-Beta Thalassemia

A disorder characterized by the body's inability to synthesize beta-globin chains, leading to the formation of abnormal hemoglobin and anemia. This inherited autosomal recessive blood disorder is caused by germline mutation of the HBB gene.


Grade 3 Cranial Nerve XI Intra-Operative Injury, CTCAE


Grade 4 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Oral Cavity NOS Intra-Operative Injury, CTCAE


Adult Acute Myeloid Leukemia with t(16;16)(p13.1;q22); CBFB-MYH11

An acute myeloid leukemia with t(16;16)(p13.1;q22) occurring in adults.


Stage IV Bone Cancer AJCC v8

Stage IV includes: IVA: (Any T, N0, M1a, Any G); IVB: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1a: Metastasis in the lung. M1b: Metastasis in the bone or other distant sites. (AJCC 8th ed.)


Grade 3 Rectum Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Infant Irritability, AE

An adverse event in a newborn characterized by mild, self-limiting, irritability, not affecting feeding and sleeping.


Grade 3 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Hemorrhoids, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Bronchopulmonary Hemorrhage, CTCAE

Death


Carcinoma in situ of ampulla of Vater

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 3 Urinary Electrolyte Wasting, CTCAE


Stage IA Pancreatic Cancer AJCC v6 and v7

Stage IA includes: T1, N0, M0. T1: Tumor limited to the pancreas, 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Recurrent Endometrial Mixed Cell Adenocarcinoma

The reemergence of endometrial mixed cell adenocarcinoma after a period of remission.


Adverse Event Severity Grade

A numeric value corresponding to the degree of severity of an adverse event.


Grade 3 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Hepatitis B Reactivation, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated


Grade 3 Sciatic Nerve Intra-Operative Injury, CTCAE


Grade 5 Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Seasickness

A sensation of discomfort associated with travel over water, which may include nausea, vomiting, dizziness, or sweating.


Grade 1 Urethra Intra-Operative Injury, CTCAE


Nail Infection, CTCAE

A disorder characterized by an infectious process involving the nail.


Grade 2 Dental-Tooth Infection with Unknown Absolute Neutrophil Count, CTCAE


Urethral Condyloma Acuminatum

A sexually transmitted papillary neoplasm that arises from the epithelial surface of the urethra, and caused by the human papillomavirus.


Acquired Factor I Deficiency

An acquired coagulation disorder characterized by the partial or complete absence of fibrinogen (factor I) activity in the blood.


Environmental and Occupational Exposure

The exposure to potentially harmful agents in the environment or to work-related environmental factors.


Body Temperature Associated Symptom

An alteration in body temperature outside the normal range.


Peritoneal Inclusion Cyst

A cyst that is located in the peritoneum and is lined by benign mesothelium.


Grade 4 Skin Intra-Operative Injury, CTCAE


Esophageal Cancer by AJCC v6 Stage

A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 6th edition.


Well Differentiated Fibrosarcoma

A well-differentiated malignant neoplasm arising from the deep soft tissues.  It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern.


Refractory Endometrial Adenocarcinoma

Endometrial adenocarcinoma that is resistant to treatment.


Luminal B Prostate Carcinoma

Prostate carcinoma associated with increased androgen receptor expression and signaling (androgen activity pathway), increased luminal markers, and a higher proliferation score than the luminal A prostate carcinoma. Patients with luminal B prostate carcinoma have the poorest prognosis but respond better to postoperative androgen deprivation therapy compared to patients with non-luminal B prostate carcinoma.


Grade 5 Small Bowel Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Intentional Trauma

An injury that is not the result of an accident or natural causes.


Grade 2 Hypocalcemia, CTCAE

Corrected serum calcium of <8.0-7.0 mg/dL; <2.0-1.75 mmol/L; Ionized calcium <1.0-0.9 mmol/L; symptomatic


Toxic methemoglobinemia with cyanosis

Blue skin coloration due to elevated blood levels of methemoglobin. The degree of cyanosis is directly correlated to the concentration of methemoglobin in the blood. As methemoglobin is not suitable for carrying oxygen, hypoxemia becomes a serious sequela.


Grade 2 Vaginal Perforation, CTCAE

Invasive intervention not indicated


Metastatic Malignant Pancreatic Neoplasm

A malignant neoplasm that arises from the pancreas and has metastasized to another anatomic site.


Grade 3 Other Hepatobiliary and Pancreas, CTCAE


Grade 2 Intraoperative Renal Injury, CTCAE

Partial resection of injured organ/structure indicated


Tracheitis, CTCAE

A disorder characterized by an infectious process involving the trachea.


Pancreatic adenocarcinoma recurrent

The reemergence of pancreatic adenocarcinoma after a period of remission.


Generalized Edema, CTCAE

A disorder characterized by fluid accumulation in the tissues of the body including the skin.


Bronchopulmonary Dysplasia, AE

An adverse event in a newborn characterized by a lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates. The condition is defined based on treatment with supplemental oxygen for at least 28 days adjusted for the degree of prematurity.


Peritoneal and Retroperitoneal Neoplasm

A benign or malignant, primary or metastatic neoplasm that affects the peritoneum and/or retroperitoneum.


Grade 5 Thorax Soft Tissue Necrosis, CTCAE


Grade 2 Joint Intra-Operative Injury, CTCAE


Hodgkin's disease nodular sclerosis stage I subdiaphragmatic


Grade 2 Pancreatitis, CTCAE

Enzyme elevation; radiologic findings only


Grade 3 Stevens-Johnson Syndrome, CTCAE

Skin sloughing covering <10% BSA with associated signs (e.g., erythema, purpura, epidermal detachment, and mucous membrane detachment)


Venous Injury, CTCAE

A finding of damage to a vein.


Grade 2 Uterus Stricture or Stenosis, CTCAE


Difficult Vascular Access

Access to the subject's vasculature is troublesome or formidable. (ACC)


acute myeloid leukemia with inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2)

An acute myeloid leukemia associated with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2) resulting in the reposition of a distal GATA2 enhancer to activate MECOM expression. It may present de novo or follow a myelodysplastic syndrome. The clinical course is aggressive.


External Ear Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the external ear region.


Grade 1 Psychosis, CTCAE

Mild psychotic symptoms


Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Upper Airway Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Hyponatremia, CTCAE

A disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood.


Grade 5 Urethral Infection, CTCAE

Death


Grade 3 Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Psoriatic Juvenile Idiopathic Arthritis

A category of juvenile idiopathic arthritis defined by the presence of arthritis with a personal or family history of psoriasis, and features such as dactylitis and nail dystrophy.


Hepatic Thrombosis

Formation of a blood clot (thrombus) in the lumen of the veins in the liver or hepatic artery.


Grade 5 Sinusitis, CTCAE

Death


Biliary Anastomotic Leak, CTCAE

A finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures).


Grade 1 Neonatal Diarrhea, AE

An adverse event in a newborn characterized by an increase of 2-4 stools per day over baseline; mild increase in ostomy output compared to baseline.


Non-Neoplastic Soft Tissue Disorder

A non-neoplastic disorder that affects the soft tissue.


Intraoperative Endocrine Injury, CTCAE

A finding of damage to the endocrine gland during a surgical procedure.


Grade 4 Duodenal Obstruction, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Intracranial Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Hyperplasia of pituitary gland

A rare condition characterized by hyperplasia and hypertrophy of the pituitary gland. It is caused by hypersecretion of hypothalamic stimulating hormones.


Recurrent Malignant Skin Neoplasm

Reemergence of a malignant skin neoplasm after a period of remission.


Grade 5 Vascular Disorders - Other, Specify, CTCAE

Death


Recurrent Malignant Scrotal Neoplasm

The reemergence of a malignant scrotal neoplasm after a period of remission.


Grade 1 Hypophysitis, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Metastatic malignant neoplasm to esophagus

A malignant neoplasm that has spread to the esophagus from another organ or system, or from another primary esophageal tumor. The primary esophageal tumor is not in continuity with the metastatic lesion. Representative examples of metastatic cancers to the esophagus include breast and lung metastatic carcinomas and melanomas.


Grade 4 Rash Acneiform, CTCAE

Life-threatening consequences; papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated


Adenomatosis, Pulmonary

This is a non-human neoplastic process described in sheep.


Grade 1 Personality Change, CTCAE

Mild personality change


Grade 5 Atelectasis, CTCAE

Death


Grade 4 Eye Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Recurrent Visual Pathway Glioma

The reemergence of visual pathway glioma after a period of remission.


Grade 4 Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Ischemia Cerebrovascular, CTCAE

Moderate symptoms


Grade 1 Periodontal Disease, CTCAE

Gingival recession or gingivitis; limited bleeding on probing; mild local bone loss


Grade 2 Wound Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 4 Esophageal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage IIIB Prostate Cancer AJCC v8

Stage IIIB includes: T3-4, N0, M0, PSA: Any, Grade Group 1-4; T3: Prostate cancer with extraprostatic tumor that is not fixed or does not invade adjacent structures. T4: Prostate cancer in which the tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


Locally Advanced Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 4 Dental-Tooth Infection with Unknown Absolute Neutrophil Count, CTCAE


Edema Trunk, CTCAE

A disorder characterized by swelling due to excessive fluid accumulation in the trunk area.


Cutaneous T Lymphoblastic Leukemia/Lymphoma

T-lymphoblastic leukemia/lymphoma that arises from the skin.


Recurrent Endometrial Mucinous Adenocarcinoma

The reemergence of endometrial mucinous adenocarcinoma after a period of remission.


Invasive Pancreatic Micropapillary Adenocarcinoma

An invasive pancreatic ductal adenocarcinoma characterized by the presence of clusters of malignant cells located within artifactual clear stromal spaces.


Grade 1 Akathisia, CTCAE

Mild restlessness or increased motor activity


Subphrenic Abscess

An abscess that is located in the anatomical space between the diaphragm and the liver and/or spleen.


Grade 2 Small Intestinal Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 2 Cranial Nerve II Neuropathy, CTCAE


Grade 2 GGT Increased, CTCAE

>2.5-5.0 x ULN if baseline was normal; >2.5-5.0 x baseline if baseline was abnormal


Grade 4 Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Colonic Fistula, CTCAE

Invasive intervention indicated


Stage III Cervical Cancer FIGO 2009

Cervical carcinoma involving lower vagina, pelvic sidewall, and ureters. (FIGO 2009)


Insomnia exacerbated

Insomnia that is made worse by other factors, including pain, physiological or psychological disorders, external causes, or pharmacologic interventions.


Grade 5 Apnea, CTCAE

Death


Recurrent Digestive System Neuroendocrine Carcinoma

The reemergence of a neuroendocrine carcinoma in any part of the digestive system after a period of remission.


Clonal Cytopenia of Undetermined Significance

Clinically meaningful cytopenia in one or more hematopoietic cell lineages. Clonal hematopoiesis is present with the variant allele frequency (VAF) equal or more that 2 percent. There is no other evidence of hematologic malignancy.


Stage IB2 Cervical Cancer AJCC v9

Stage IB2 includes: T1b2, N0, M0. T1b2: Tumor measuring more than 2 cm and equal or less than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 1 Rash Maculo-Papular, CTCAE

Macules/papules covering <10% BSA with or without symptoms (e.g., pruritus, burning, tightness)


Sickening Pain

A sensation of discomfort or distress that makes the individual queasy or nauseated.


Grade 2 Skin Atrophy, CTCAE

Covering 10-30% BSA; associated with striae or adnexal structure loss


Grade 3 Budd-Chiari Syndrome, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; asterixis; mild encephalopathy


Grade 2 Neonatal Respiratory Insufficiency, AE

An adverse event in a newborn characterized by clinical evidence of increased respiratory distress without significant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); corrected by minor adjustments in current ventilatory support, supplemental oxygen or non-invasive support.


Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Restrictive Cardiomyopathy, CTCAE

Death


Refractory HIV-Related Lymphoproliferative Disorder

HIV-associated lymphoproliferative disorder that is resistant to treatment.


Refractory Barrett Esophagus

Dysplasia in Barrett esophagus that is resistant to treatment.


Prostatic Obstruction, CTCAE

A disorder characterized by compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder).


Constipation, CTCAE

A disorder characterized by irregular and infrequent or difficult evacuation of the bowels.


Advanced Merkel Cell Carcinoma

A Merkel cell carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Grade 4 Cranial Nerve VIII Intra-Operative Injury, CTCAE


Intermediate Osteogenic Neoplasm

A non-metastasizing, locally aggressive, bone-forming neoplasm.


Grade 5 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Duodenal Infection, CTCAE

Death


Grade 1 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Dialysis dementia

A severe, often fatal encephalopathy which has been attributed to accumulation in the brain of aluminum from dialysate prepared with inadequately purified water.


Grade 5 Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


Malignant Lymphoma, Large Cell, Cleaved and Non-Cleaved

Antiquated term describing follicular (nodular) or diffuse non-Hodgkin lymphomas that are composed of a mixture of large cells: large cleaved cells, with irregular nuclei without visible nucleoli; and large non-cleaved cells (centroblasts), having a rounder nucleus with two to three small, peripherally placed nucleoli and a small amount of basophilic cytoplasm.  The follicular variants represent mature B-cell lymphomas, whereas the diffuse variants can be either mature B- or mature T-cell lymphomas.


Acute hemorrhagic edema of infancy

A self-limiting cutaneous vasculitis that typically presents as a clinical triad of purpura, edema, and fever in children between the ages of four months and two years old. It is usually associated with a recent history of upper respiratory infection and/or antibiotic therapy.


A reactive cutaneous proliferation of macrophages associated with local trauma. It is characterized by the presence of giant cells with ground-glass cytoplasm. It presents as a single, asymptomatic, cutaneous or mucosal, firm xanthomatous to dark-red papule or nodule. (WHO 2018)


Low grade myofibroblastic sarcoma

A low grade malignant neoplasm arising from the deep soft tissues.  It is characterized by the presence of spindle-shaped myofibroblasts and collagenous stroma formation in a storiform growth pattern.  Metastasis is very rare.


Cutaneous Precursor Lymphoid Neoplasm

A precursor lymphoid neoplasm that arises from the skin.


Tearing Chest Pain

The sensation of chest pain described as a sharp, lacerating, intense, discomfort; sometimes used to describe the pain felt during an aortic dissection.


Stage IIIA Cervical Cancer AJCC v9

Stage IIIA includes: T3a, N0, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Adult Erythroleukemia

An erythroleukemia occurring in adults.


Grade 1 Ileal Obstruction, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Lymphangioma of liver

A rare lymphangioma that arises from the liver.  It usually occurs in children and adolescents.


Grade 5 Esophagitis, CTCAE

Death


Urinary Urgency, CTCAE

A disorder characterized by a sudden compelling urge to urinate.


Grade 4 Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic sarcoma

A sarcoma that has spread from its original site of growth to another anatomic site.


Grade 4 Jejunal Perforation, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 5 Liver Dysfunction or Failure by Clinical Classification, CTCAE


Grade 4 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Euphoria, CTCAE

Mild mood elevation


Stage IIIB Ampulla of Vater Cancer AJCC v8

Stage IIIB includes: (T4, Any N, M0); (Any T, N2, M0). T4: Tumor involving the celiac axis, superior mesenteric artery, and/or common hepatic artery, irrespective of size. N2: Metastasis to four or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Acute Vascular Leak Syndrome, CTCAE


Grade 1 Associated with Dentures or Dental Prosthesis, CTCAE


Stage IA1 Cervical Cancer FIGO 2009

Cervical carcinoma measuring equal or less than 3 mm in depth. (FIGO 2009)


Unresectable Liposarcoma

A liposarcoma which is not amenable to surgical resection.


Grade 2 Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage II Ampulla of Vater Cancer AJCC v7

Stage II includes: IIA (T3, N0, M0); IIB (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invades the pancreas.  T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades the duodenal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Teratoma with Endocrine Differentiation

A teratoma that arises outside an endocrine organ and shows endocrine differentiation. The endocrine component ranges from benign endocrine tissue to malignant endocrine neoplasms. This category includes struma ovarii, thyroid carcinoma arising in struma ovarii, and carcinoid tumor arising in ovarian teratoma.


Grade 2 Wound Complication, CTCAE

Bedside local care indicated


Injury of adrenal gland

Trauma to the adrenal gland.


Gastrointestinal Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures).


T-Cell Prolymphocytic Leukemia, Small Cell Variant

A T-cell prolymphocytic leukemia characterized by the presence of small neoplastic prolymphocytes often with invisible nucleolus by light microscopy.


Advanced Anal Carcinoma

Anal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Myeloproliferative Neoplasm

A myeloproliferative neoplasm that does not respond to treatment.


Immune Dysregulation Disorder

A group of autoimmune disorders characterized by defects in self-tolerance (central or peripheral) resulting in autoimmune disease with or without recurrent infections, comprised by: Familial hemophagocytic lymphohistiocytosis (FHL) syndromes; FHL syndromes with hypopigmentation; Regulatory T cell (Treg) defects (eg, IPEX); Autoimmunity with or without lymphoproliferation (eg, autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy [APECED]); Autoimmune lymphoproliferative syndrome (ALPS); Immune dysregulation with colitis; and Susceptibility to Epstein-Barr virus (EBV) and lymphoproliferative conditions.


Grade 3 Neck Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE


Stage III Pancreatic Cancer AJCC v8

Stage III includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. T4: Tumor involving the celiac axis, superior mesenteric artery, and/or common hepatic artery, regardless of size. N2: Metastasis in four or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage I Childhood Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Frontal Lobe Anaplastic Oligodendroglioma

An anaplastic oligodendroglioma occurring in the frontal lobe.


Ann Arbor Stage II Supradiaphragmatic Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the superior side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph node(s) with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript.


Grade 4 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Hepatic Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Grade 2 Gallbladder Intra-Operative Injury, CTCAE


Intraoperative Musculoskeletal Injury, CTCAE

A finding of damage to the musculoskeletal system during a surgical procedure.


A non-invasive neoplastic process that affects the epithelium of any part of the digestive system.  It is characterized by the presence of morphologic features of dysplasia (e.g., architectural and cytological epithelial alterations) or, in a minority of cases, lack of such morphologic features, as in colonic sessile serrated adenomas/polyps.


Prostatic Atypical Adenomatous Hyperplasia

A prostatic hyperplasia characterized by the presence of crowded adenomatous epithelial nodules.


Urethral Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures).


Genitourinary malfunction arising from mental factors

A dysfunction in genitourinary function that is due to a psychological process.


Injury of bladder

Trauma to the bladder.


Grade 4 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Mixed acinar-ductal carcinoma

A carcinoma that arises from the pancreas showing either extensive mucin accumulation and acinar neoplastic cells or a mixture of columnar or signet-ring cells and acinar neoplastic cells.


Erythema toxicum neonatorum

A benign, self-limited eruption of vesicles, pustules, papules and macules seen in newborns. An eosinophilic infiltrate can be isolated suggesting an immune-mediated reaction in the skin.


Grade 2 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Gastric Adenoma, Gastric-Type

A neoplastic polyp that arises from the stomach.  It is characterized by the presence of gastric epithelial differentiation.  It includes pyloric gland adenomas and foveolar-type adenomas.


Tourettism

Tics that are secondary to an identifiable cause.


Periorbital Infection

An infectious process affecting the tissues around the orbit.


Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Esophageal Varices Hemorrhage, CTCAE


Gallbladder Cancer by AJCC v7 Stage

A term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 7th edition.


Grade 5 Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pulmonary Fistula

An abnormal communication between the lung and another organ or anatomic site.


Grade 2 Virilization, CTCAE

Moderate symptoms; medical intervention indicated


Grade 2 Somnolence, CTCAE

Moderate sedation; limiting instrumental ADL


Stage IV Uterine Corpus Cancer AJCC v8

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus carcinoma or carcinosarcoma with tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, lung, liver, or bone. It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa). (from AJCC 8th Ed.)


Localized Sarcoma

A sarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Grade 3 Biliary Fistula, CTCAE

Invasive intervention indicated


Grade 4 Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


Recurrent Human Papillomavirus-Related Malignant Neoplasm

The reemergence of human papillomavirus-related malignant neoplasm after a period of remission.


Stage IIB Gestational Trophoblastic Tumor AJCC v7

Stage IIB includes: T2, M0, Risk factors: high risk.  T2: Tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension.  M0: No distant metastasis.  (AJCC 7th ed.)


Drug-induced gingival hyperplasia

Overgrowth of the gingival tissue caused by phenytoin, cyclosporine A, and calcium channel blockers.


Grade 5 Penile Infection, CTCAE

Death


Stage IB Cervical Cancer FIGO 2018

Invasive cervical carcinoma with measured deepest invasion equal or more than 5 mm (greater than Stage IA), lesion limited to the cervix uteri. (FIGO 2018)


Grade 1 Pharyngolaryngeal Pain, CTCAE

Mild pain


Hematoma, CTCAE

A disorder characterized by a localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel.


Grade 2 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


Radiating Chest Pain Along Sternal Border

The location of the radiating chest pain is along the lateral edge of the sternum.


Recurrent Lymphoma

The reemergence of a lymphoma after a period of remission.


Hypokalemia, CTCAE

A disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood.


Grade 2 Pancreatic Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Face Pain, CTCAE

Unintended facial pain associated with a medical procedure or administration of a drug.


Grade 3 Rectum Stricture or Stenosis, CTCAE


Grade 5 Hypomagnesemia, CTCAE

Death


Grade 3 Ileal Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated


Stage IV Fallopian Tube Cancer AJCC v6 and v7

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes metastasis within the peritoneal cavity). (AJCC 6th and 7th eds.)


Stage IVA Bone Cancer AJCC v7

Stage IVA includes: Any T, N0, M1a, Any G.  N0: No regional lymph node metastasis.  M1a: Distant metastasis to lung. (AJCC 7th ed.)


Neoplasms, Unknown Primary

The spread of a malignant neoplasm from an unknown primary to another region remote from the primary site.


Grade 1 Esophageal Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Inguinal hernia, without mention of obstruction or gangrene

The protrusion of abdominal cavity contents through the inguinal canal, without mention of obstruction or necrosis of the herniated contents.


Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


Extragonadal primary germ cell tumor mixed stage III


Polyarticular Still Disease

Juvenile rheumatoid arthritis affecting multiple joints, usually symmetrically. It may be associated with low grade fever, anemia, and weight loss. Patients usually test negative for rheumatoid factor.


Stage II Contiguous Adult Diffuse Small Cleaved Cell Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ).


Advanced Paraganglioma

A paraganglioma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adult Meningioma

A meningioma that occurs during adulthood.


Coronary artery ectasia

Diffuse dilation of a coronary artery segment.


Stage IIA2 Cervical Cancer AJCC v7

Stage IIA2 includes: T2a2, N0, M0.  Tumor invades beyond uterus but no to pelvic wall or to lower third of vagina. No parametrial invasion.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Recurrent Anal Squamous Cell Carcinoma

The reemergence of anal squamous cell carcinoma after a period of remission.


Grade 2 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Industrial Accident

An accident taking place on the site of a commercial enterprise.


Stage IIIB Uterine Corpus Cancer AJCC v8

Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus carcinoma or carcinosarcoma with vaginal involvement (direct extension or metastasis) or parametrial involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)