Locally Advanced Squamous Cell Carcinoma

A squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Fallopian Tube Perforation, CTCAE

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Invasive intervention indicated


Grade 4 Alkalosis, CTCAE

Life-threatening consequences


Grade 4 Neck NOS Intra-Operative Injury, CTCAE


Major Congenital Anomaly

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A major congenital anomaly is a structural or functional defect with the following three characteristics: 1) Of prenatal origin; 2) Present at the time of live birth or fetal demise, or in utero; 3) Affecting (or has the propensity to affect) the health, survival, or physical or cognitive functioning of the individual.


Carcinoma of unknown primary

A carcinoma which has metastasized from an unknown primary anatomic site.


Grade 2 Anal Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Acute Kidney Injury, CTCAE

A disorder characterized by the acute loss of renal function (within 2 weeks) and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction).


Hematopoietic and Lymphoid Neoplasm (Antiquated)


Grade 3 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Blood Bicarbonate Decreased, CTCAE

A finding based on laboratory test results that indicate a decrease in levels of bicarbonate in a venous blood specimen.


Grade 1 Colonic Fistula, CTCAE

Asymptomatic


Adverse Event with No Consequence or Impact

No apparent harm occurred in relation to the adverse event.


Clinical Chorioamnionitis

Inflammation of the fetal sac membranes, characterized by otherwise unexplained fever (at or above 38 degree C (100.4F)) with one or more of the following: uterine tenderness and/or irritability, leukocytosis, fetal tachycardia, maternal tachycardia, or malodorous vaginal discharge.


Ventral hernia without mention of obstruction or gangrene

The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, without mention of obstruction or necrosis of the herniated contents.


Lumbar meningomyelocele

A congenital abnormality in the lumbar region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Grade 4 Pharyngeal Hemorrhage, CTCAE

Life-threatening consequences; intubation or urgent intervention indicated


Grade 5 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Grade 3 Dysarthria, CTCAE

Severe impairment of articulation or slurred speech


Grade 4 Brachial Plexus Intra-Operative Injury, CTCAE


Adverse Event by CTCAE v4 Severity Grade


Autoimmune Atrophic Chronic Gastritis

Chronic atrophic gastritis that is caused by autoimmune destruction of parietal cells in the stomach resulting in hypochlorhydria and decreased production of intrinsic factor.


Stage I Low-CSD Melanoma AJCC v7

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 3 Papilledema, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200)


Grade 5 Intraoperative Head and Neck Injury, CTCAE

Death


Grade 4 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Central Nervous System Hemorrhage, CTCAE


Grade 4 Intraoperative Gastrointestinal Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Urinary Tract NOS Intra-Operative Injury, CTCAE


Grade 2 Hepatobiliary Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 4 Nails Intra-Operative Injury, CTCAE


Malignant Bladder Paraganglioma

An extra-adrenal sympathetic paraganglioma of the bladder that metastasizes to other anatomic sites.


Grade 2 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Gallbladder Infection, CTCAE

A disorder characterized by an infectious process involving the gallbladder.


Grade 4 Persistent Pulmonary Hypertension of the Newborn, AE

A persistent pulmonary hypertension adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; extracorporeal membrane oxygenation (ECMO) required; oxygenation index greater than 40.


Grade 4 Artery NOS Intra-Operative Injury, CTCAE


Infant Leukemia

An acute lymphoblastic or acute myeloid leukemia that occurs in infancy.


Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Complication due to Medical/Surgical Care

An untoward event that can be attributed to care received during a medical/surgical event.


Ancylostomiasis due to Ancylostoma ceylonicum (disorder)

Infection by Ancylostoma ceylanicum.


Distal Esophagus Adenocarcinoma

An adenocarcinoma arising from the lower third of the esophagus. The vast majority of esophageal adenocarcinomas involve the lower third of the esophagus.


Grade 3 Rectal Necrosis, CTCAE

Tube feeding or TPN indicated; invasive intervention indicated


Grade 2 Peripheral Sensory Neuropathy, CTCAE

Moderate symptoms; limiting instrumental ADL


Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Neonatal Intraventricular Hemorrhage, AE

An adverse event in a newborn characterized by hemorrhage occupying less than 50% of ventricular volume without ventricular dilatation greater than 4mm above the 97th percentile.


Elevated EBV DNA

A finding indicating elevated concentrations of Epstein-Barr virus DNA in a sample.


Cervical intraepithelial neoplasia grade 1

Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Diffuse KATP-Associated Hyperinsulinism

KATP-associated hyperinsulinism affecting all pancreatic beta cells.


Recurrent Acute Erythroid Leukemia

The reemergence of acute erythroid leukemia after a period of remission.


Anxiety disorder due to a general medical condition

An anxiety disorder in which the symptoms of anxiety have been determined to be the direct physiological consequence of a general medical condition.


Aspiration, CTCAE

A disorder characterized by inhalation of solids or liquids into the lungs.


Grade 2 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Stage IVB Cervical Cancer FIGO 2009

Cervical carcinoma involving distal organs outside the pelvis. (FIGO 2009)


Basal cell carcinoma - keratotic

A variant of basal cell carcinoma with the architectural features of a nodular basal cell carcinoma.  It is characterized by the formation of keratin (horn cysts) in the center of the tumor islands.  Dystrophic calcification is frequently present.


Grade 5 Pyramidal Tract Dysfunction, CTCAE


Grade 4 Bronchopleural Fistula, CTCAE

Life-threatening consequences; urgent intervention indicated


Complication

Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure.


Anaplastic Diencephalic Astrocytoma

An anaplastic astrocytoma that occurs in the diencephalon.


Grade 4 Respiratory Tract Hemorrhage NOS, CTCAE


A reactive proliferation of the conjunctival squamous epithelium not associated with glandular elements.


Philadelphia Chromosome Negative BCR-ABL1 Negative Chronic Myelogenous Leukemia


Grade 2 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Lymphoproliferative Disease Associated with Primary Immune Disorder

A lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder. The primary immune disorders most frequently associated with lymphoproliferative disorders are ataxia-telangiectasia, Wiskott-Aldrich syndrome, common variable immunodeficiency, severe combined immunodeficiency, X-linked lymphoproliferative disease, Nijmegen breakage syndrome, hyper-IgM syndrome, and autoimmune lymphoproliferative syndrome. (WHO 2017)


Grade 4 Leukocytosis, CTCAE

Clinical manifestations of leucostasis; urgent intervention indicated


Grade 2 Bladder Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Radiating Chest Pain Along Right Lower Sternal Border

The location of the radiating chest pain is along the right lower sternal border.


Recurrent Histiocytic and Dendritic Cell Neoplasm

The reemergence of a histiocytic and dendritic cell neoplasm after a period of remission.


Grade 1 Pancreatic Fistula, CTCAE

Asymptomatic


Stage III Childhood Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Vascular anomaly of eyelid

Any non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels of the eyelid.


Stage III Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0). T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. T3: Tumor of any size with invasion into surrounding tissues (e.g., liver, pancreas, spleen, kidneys). N1: Regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Stage IIIA Esophageal Adenocarcinoma AJCC v7

Stage IIIA includes: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Oligospermia, CTCAE

A disorder characterized by a decrease in the number of spermatozoa in the semen.


Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Grade 3 Appendix Intra-Operative Injury, CTCAE


verrucous carcinoma of vagina

A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, acanthotic epithelium with minimal or absent atypia, and pushing borders.


Elevated LDH

An indication that the concentration of lactate dehydrogenase found in a sample is higher than previous noted or above the normal range.


Grade 1 Injection Site Reaction, CTCAE

Tenderness with or without associated symptoms (e.g., warmth, erythema, itching)


Grade 4 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Injection Site Reaction, CTCAE

Death


Grade 5 Laryngeal Stenosis, CTCAE

Death


Grade 4 Blood Bilirubin Increased, CTCAE

>10.0 x ULN if baseline was normal; >10.0 x baseline if baseline was abnormal


Grade 1 Lower Extremity Intra-Operative Injury, CTCAE


Testicular Seminoma with Syncytiotrophoblastic Cells

A testicular seminoma characterized by the presence of syncytiotrophoblastic giant cells.


Peritoneal Implant

Deposits of borderline, malignant, and rarely benign tumors, usually from the ovary, on the peritoneal surface.


Grade 1 Anorgasmia, CTCAE

Inability to achieve orgasm not adversely affecting relationship


Infections and Infestations - Other, Specify, CTCAE


Sinusitis, CTCAE

A disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses.


Grade 2 Recurrent Laryngeal Nerve Palsy, CTCAE

Moderate symptoms


Grade 4 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 2 Cranial Nerve VI Intra-Operative Injury, CTCAE


Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

An acute myeloid leukemia with recurrent genetic abnormalities occurring in adults.


High Grade Liver Dysplastic Nodule

A hepatic dysplastic nodule characterized by the presence of high grade atypical cellular changes.


Sporadic Gastric Adenocarcinoma

A primary adenocarcinoma of the stomach in a patient with no family history of gastric cancer or inherited high risk mutations.


Subacute Placental Infarction

A focus of necrotic placental parenchyma with moderate hyalinization and fibrosis with partial absence of the necrotic chorionic villi, which is frequently 3-5 days of duration.


K ATP Permanent Neonatal Diabetes

K ATP channel-associated neonatal diabetes mellitus that does not resolve spontaneously.


Grade 5 Superior Vena Cava Syndrome, CTCAE

Death


Resectable Sarcoma

Sarcoma that is amenable to surgical resection.


Periorbital Edema, CTCAE

A disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face.


Grade 3 Renal and Urinary Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Accident

An unforeseen and unplanned event or circumstance frequently causing loss or injury.


Clinical Stage I Cutaneous Melanoma AJCC v8

Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 2 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Laryngeal Nerve Dysfunction, CTCAE


Grade 3 Hemolytic Uremic Syndrome, CTCAE

Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae)


Grade 2 Cranial Nerve VIII Intra-Operative Injury, CTCAE


Endometrial cystic hyperplasia

Benign endometrial hyperplasia characterized by the presence of cystically dilated glands.


Pulmonary Fibrosis Radiographic Changes, CTCAE


Grade 2 Pancreas Exocrine Enzyme Deficiency, CTCAE


Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Otitis Externa, CTCAE

Localized, local intervention indicated


Imaging Finding

The result of an evaluation technique using a visual display of structural or functional patterns of organs or tissues that is performed to determine the presence, absence, or degree of a condition.


Meniscal Cyst

A cyst located at the periphery of the meniscus.


Grade 1 Hypotension, CTCAE

Asymptomatic, intervention not indicated


Grade 3 Neuralgia and Peripheral Nerve Pain, CTCAE


Malignant Lymphoma, Histiocytic, Diffuse


Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Papillary mucinous cystadenoma

A usually benign and less often low malignant potential cystic epithelial neoplasm composed of cells which contain intracytoplasmic mucin. It is characterized by the presence of papillary structures.


Acute gonococcal infection of lower genitourinary tract

A gonococcal infection of the lower urinary tract that is rapid in onset.


Musculoskeletal Chest Pain due to Rib Injury

A condition in which there is musculoskeletal chest pain secondary to trauma to one or more ribs. (ACC/AHA)


Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Bronchial Infection, CTCAE

A disorder characterized by an infectious process involving the bronchi.


Parathyroid Clear Cell Hyperplasia

A hyperplasia of the clear cells of the parathyroid gland.


Paradental Cyst

An inflammatory collateral cyst that arises on the lower third molars. (WHO 2017)


FIGO Stage II Gestational Trophoblastic Tumor

Lesion invades outside of the uterus, but it is limited to the genital structures.


Malignant Paraganglionic Neoplasm

A paraganglioma that metastasizes to regional or distant anatomic sites.  Extraadrenal paragangliomas have a higher tendency to metastasize, as compared to pheochromocytomas.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


Psychotic disorder due to a general medical condition

A psychotic disorder characterized by prominent hallucinations or delusions that have been determined to be etiologically linked to a general medical condition.


Grade 1 Lymphedema, CTCAE

Trace thickening or faint discoloration


Grade 4 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Grade 2 Ileus, CTCAE

Symptomatic; altered GI function; bowel rest indicated


Grade 1 Hematuria, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 5 Laryngitis, CTCAE

Death


Stage II Prostate Cancer AJCC v7

Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Stage IV Cervical Cancer FIGO 2018

The cervical carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. (A bullous edema, as such, does not permit a case to be allotted to Stage IV). (FIGO 2018)


Encephalopathy of Prematurity

A condition affecting premature infants characterized by white matter injury, which is frequently accompanied by neuronal/axonal disease, that may affect all brain parenchymal structures and is due to a combination of destructive processes as well as maturational and trophic disturbances.


Grade 2 Alcohol Intolerance, CTCAE

Present


Grade 3 Prolonged Intubation After Pulmonary Resection, CTCAE


Grade 4 Tracheitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Severe Aplastic Anemia

Life-threatening anemia associated with a high risk of infection or bleeding.


Refractory Extracranial Malignant Solid Neoplasm

An extracranial malignant solid neoplasm that is resistant to treatment.


Flat adenoma

An adenoma of the gastrointestinal tract mucosa which grossly and morphologically does not appear as an elevated or polypoid lesion.


Grade 2 Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


Aorta Artery Intra-Operative Injury, CTCAE


Pathologic Stage III Esophageal Adenocarcinoma AJCC v8

Stage III includes: IIIA: (T1, N2, M0, Any G); (T2, N1, M0, Any G); IIIB: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Adult Solid Neoplasm

A solid neoplasm (e.g., carcinoma, sarcoma) occurring in adults.


Grade 2 Conjunctiva Intra-Operative Injury, CTCAE


Grade 2 Gastrointestinal Stoma Hemorrhage, CTCAE


Grade 5 Colon Stricture or Stenosis, CTCAE


Disseminated Intravascular Coagulation, CTCAE

A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors.


Ampulla of Vater Neuroendocrine Tumor by AJCC v8 Stage

A term that refers to the staging of an ampulla of Vater neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to well-differentiated neuroendocrine tumors of the ampulla of Vater. Carcinomas of the ampulla of Vater, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not included in this staging system. (from AJCC 8th Ed.)


Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


Aggressive digital papillary adenoma

An eccrine sweat gland adenoma with aggressive local growth. Most cases present as nodular lesions on the digits. It is characterized by the presence of tubular and ductal structures with areas of papillary projections into cystic lumina.


Grade 1 Hypophosphatemia, CTCAE

Laboratory finding only and intervention not indicated


Ductal Eccrine Carcinoma with Spindle Cell Elements

A variant of ductal eccrine carcinoma with spindled cell appearance.


Pancreatic carcinoma recurrent

The reemergence of pancreatic carcinoma after a period of remission.


Seropositive rheumatoid arthritis

Rheumatoid arthritis in which a patient's serum is positive for certain disease-related antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is more specific than RF which can be found in other pathologic conditions. The production of these disease-associated antibodies may precede the development of clinical symptoms by several years. Seropositive patients have a greater likelihood of developing extra-articular complications and a more severe course of disease.


Spitzoid melanoma

A melanoma that shares histopathologic and clinical features with atypical Spitz nevus.


Grade 2 Fall, CTCAE

Symptomatic; noninvasive intervention indicated


Acquired Rickets

Rickets that is caused by vitamin D deficiency, hypocalcemia, or renal failure.


Diffuse Glioma

A glioma that has diffusely infiltrated the surrounding central nervous system tissues.


Grade 4 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Urethra Stricture or Stenosis, CTCAE


Acquired Phrenic Nerve Injury

Damage to the phrenic nerve that was not present at birth.


Grade 4 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Non-Infectious Wound Complication, CTCAE


Grade 1 Trigeminal Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Cranial Nerve VI Intra-Operative Injury, CTCAE


Vulvar Squamous Intraepithelial Lesion, HPV-Associated

An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by maturation abnormalities and nuclear hyperchromasia that are confined to the basement membrane.


Grade 1 Enterovesical Fistula, CTCAE

Asymptomatic


Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8

Stage IC includes: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Childhood Mixed Cellularity Classic Hodgkin Lymphoma

Mixed cellularity classic Hodgkin lymphoma occurring in childhood.


Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Cebocephaly

A congenital abnormality characterized by a malformation of the head. The eyes are hypoteleric and the nose may be absent or misshapen (small, flattened, single nostril) and defective.


Stage I Skin Cancer

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness, Clark level equal or greater than IV, and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


Grade 2 Presyncope, CTCAE

Present (e.g., near fainting)


Eyelid Function Disorder

A disorder characterized by impaired eyelid function.


Wrist Fracture, CTCAE

A finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken.


Stage IVB Prostate Cancer AJCC v8

Stage IVB includes: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


Grade 5 Neonatal Diarrhea, AE

A diarrhea adverse event in a newborn which results in death.


Stage IIC Testicular Cancer AJCC v8

Stage IIC includes: (Any pT/TX, N3, M0, S0); (Any pT/TX, N3, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Grade 3 Nasopharynx Intra-Operative Injury, CTCAE


More Than Two Separate Tumor Masses Present in the Same Organ

A finding indicating the presence of more than two separate tumor masses in the same organ.


Grade 4 Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Oral Dysesthesia, CTCAE

Disabling pain; tube feeding or TPN indicated


Grade 4 Uterine Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Eye Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Peripheral Arterial Ischemia, CTCAE


Grade 3 Other Pulmonary and Upper Respiratory, CTCAE


Glossopharyngeal Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the glossopharyngeal nerve (ninth cranial nerve).


Breast Columnar Cell Lesion

A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma.  These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units.  Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ.  Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known.


Lymphoma, Mixed-Cell

An antiquated term that refers to a lymphoma composed of a mixture of small and large lymphocytes.


Lugano Classification Stage III Adult Hodgkin Lymphoma AJCC v8

Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Pre-Gestational Diabetes

Diabetes diagnosed before current pregnancy. (reVITALize)


Grade 5 Other Blood and Bone Marrow, CTCAE


Type II Endometrial Adenocarcinoma

A classification of primary endometrial adenocarcinomas that refers to clear cell adenocarcinoma, serous adenocarcinoma, and serous endometrial intraepithelial carcinoma.


Adenovirus DNA Viremia

A laboratory test result indicating the presence of adenovirus DNA in the blood.


Grade 2 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Degenerated Schwannoma

A schwannoma that is characterized by degenerative changes such as hyalinization, hemorrhage, calcification and cystic change.


Retinopathy of Prematurity, AE

An adverse event characterized by a retinal condition of very immature infants that may be characterized by non-vascularized retinae that may lead to neovascularization, scarring, retinal detachment, and blindness.


Grade 5 Enterocolitis, CTCAE

Death


Grade 5 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Hypothermia, CTCAE

<=28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation)


Grade 2 Hypoxic Ischemic Encephalopathy, AE

An adverse event in a newborn characterized by mild transient clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event;  necessitating observation and additional care.


Lymph Gland Infection, CTCAE

A disorder characterized by an infectious process involving the lymph nodes.


Unresectable Midgut Neuroendocrine Tumor

A midgut neuroendocrine tumor that is not amenable to surgical resection.


Factor II Inactivation

Presence of inactivating antibodies to prothrombin (factor II) in the blood.


Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8

Stage IB includes: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. (AJCC 8th ed.)


Grade 1 Small Bowel Obstruction NOS, CTCAE


Fetus Small for Gestational Age with Abnormal Doppler

A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and has abnormal Doppler studies.


Grade 3 Urine Output Decreased, CTCAE

Adult: Oliguria (<80 ml in 8 hr); Infants: < 0.5 mL/kg per hour for 24 hours; Children: < 500 mL/1.73 m2 body surface area per day


Grade 2 Large Intestinal Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 2 Hypopituitarism, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 5 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Cranial Nerve VIII Neuropathy, CTCAE


Grade 4 Urethra Stricture or Stenosis, CTCAE


Grade 3 Otitis External Ear Non Infectious, CTCAE


Grade 3 Hepatic Pain, CTCAE

Severe pain; limiting self care ADL


Grade 3 Dysesthesia, CTCAE

Severe sensory alteration; limiting self care ADL


Anorgasmia, CTCAE

A disorder characterized by an inability to achieve orgasm.


Grade 5 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic squamous cell carcinoma to skin

A squamous cell carcinoma that has spread to the skin from another anatomic site.


Peripheral neuropathy due to and following antineoplastic therapy

Any disorder affecting the peripheral nerves resulting from exposure to chemotherapeutic agents.


Grade 4 Cranial Nerve XI Intra-Operative Injury, CTCAE


Finding

Clinical, laboratory or molecular evidence, or absence of evidence of disease.


Grade 5 Gastrointestinal Leak NOS, CTCAE


Depression, CTCAE

A disorder characterized by melancholic feelings of grief or unhappiness.


Type I Total Anomalous Pulmonary Venous Return

Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the superior vena cava.


Corneal Ulcer, CTCAE

A disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber.


Grade 3 Thorax Soft Tissue Necrosis, CTCAE


Grade 3 Non-Myocardial Visceral Arterial Ischemia, CTCAE


Childhood Solid Neoplasm

A solid neoplasm (e.g., carcinoma, sarcoma) occurring in children.


Salivary Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic Low Grade Glioma

Low grade glioma that has spread from its primary site to another anatomic site.


Grade 5 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Substance-Induced Persisting Amnestic Disorder

A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the persisting effects of substance use. The memory impairment persists beyond the usual duration of substance intoxication or withdrawal.


Pulmonary Artery Intra-Operative Injury, CTCAE


Grade 3 Cerebral Artery Intra-Operative Injury, CTCAE


Grade 3 Cerebrospinal Fluid Leakage, CTCAE

Severe symptoms; medical intervention indicated


Platinum-Resistant Urothelial Carcinoma

Urothelial carcinoma that is resistant to platinum therapy.


Liver Lymphangiomatosis

Multiple lymphangiomas that affect the liver and other anatomic sites. Although histologically benign, diffuse lymphangiomatosis that affects the liver and multiple organs has a poor prognosis.


Supratentorial Ependymoma, Not Otherwise Specified

A circumscribed ependymoma that arises from the supratentorial region of the brain in which the genetic analysis for fusion genes involving ZFTA or YAP1 genes was unsuccessful or not reported.


Thoracic Nodule

A nodular lesion that develops in the chest wall.


Grade 1 Tongue Intra-Operative Injury, CTCAE


Stage II Merkel Cell Carcinoma AJCC v7

Stage II includes: IIA: (T2/T3, pN0, M0), IIB: (T2/T3, cN0, M0), and IIC: (T4, N0, M0).  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Grade 2 Neck Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pharyngeal Fistula, CTCAE

A disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site.


Mixed subtype adenocarcinoma of lung

The most frequently seen morphologic variant of lung adenocarcinoma characterized by a mixture of architectural patterns, including acinar, papillary, bronchioloalveolar, and solid pattern.


Grade 3 Acute Vascular Leak Syndrome, CTCAE


Vital Exhaustion

A condition characterized by excessive fatigue and lack of energy, increasing irritability, and feelings of demoralization. Persons who experience this condition are not at an increased risk for cancer.


Arachnoiditis, CTCAE

A disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space.


Hemorrhagic cyst

A cyst containing blood.


Grade 4 Lymphocyte Count Decreased, CTCAE

<200/mm3; <0.2 x 10e9/L


Recurrent Anal Canal Squamous Cell Carcinoma

The reemergence of anal canal squamous cell carcinoma after a period of remission.


Grade 2 Other Sexual Reproductive Function, CTCAE


Peripheral Nerve Infection, CTCAE

A disorder characterized by an infectious process involving the peripheral nerves.


Stage IIA1 Cervical Cancer FIGO 2009

Cervical carcinoma limited to the upper two-thirds of the vagina and is equal or less than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Muscle Disorder

A non-neoplastic disorder that affects the smooth, skeletal, or cardiac muscles.


Cranial Nerve Infection, CTCAE

A disorder characterized by an infectious process involving a cranial nerve.


Grade 2 Biliary Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Grade 1 Wheezing, CTCAE

Detectable airway noise with minimal symptoms


Stage III Extragonadal Non-Seminomatous Germ Cell Tumor


Grade 1 Blood Bicarbonate Decreased, CTCAE

<LLN and no intervention initiated


Vaginal Adenoid Basal Carcinoma

A carcinoma that arises from the vagina and is characterized by the presence of nests of basaloid cells with focal glandular formations.


Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 1 Meninges Intra-Operative Injury, CTCAE


Nose Deformities, Acquired

A non-congenital malformation of the nose.


Retinoblastoma by AJCC v8 Stage

A term that refers to the staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition. This staging system does not apply to central nervous system component of "trilateral retinoblastoma" (is staged according to the classification for brain and spinal cord), retinoma (or retinocytoma) (no AJCC staging system), and medulloepithelioma (no AJCC staging system). (from AJCC 8th Ed.)


Serious Adverse Drug Reaction

A noxious and unintended response to a medicinal product occurring at any dose that results in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in a persistent or significant disability/incapacity, or results in a congenital anomaly/birth defect.


Gallbladder Intracholecystic Papillary (Tubular) Neoplasm with Intermediate Grade Intraepithelial Neoplasia

An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of moderate epithelial atypia.


Grade 3 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Bullous Dermatitis, CTCAE

Death


Grade 3 Endophthalmitis, CTCAE

Systemic intervention; hospitalization indicated


Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Unresectable Distal Esophagus Adenocarcinoma

Distal esophagus adenocarcinoma that is not amenable to surgical resection.


Grade 3 Breast Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; severe infection; axillary adenitis


Grade 2 Seroma, CTCAE

Symptomatic; simple aspiration indicated


Grade 3 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Thoracoschisis

A congenital fissure of the thoracic wall.


Grade 4 Edema of the Head and Neck, CTCAE


Grade 3 Hypophosphatemia, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated


Grade 5 Intraoperative Ocular Injury, CTCAE

Death


Grade 2 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intraepithelial Neoplasia in Barrett Esophagus

Glandular intraepithelial neoplasia arising in Barrett esophagus.


Grade 3 Hyperkalemia, CTCAE

>6.0-7.0 mmol/L; hospitalization indicated


Small plaque parapsoriasis

A variant of parapsoriasis in which the plaques are small.


Grade 2 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Chylothorax, CTCAE

Death


Gallbladder Cribriform Carcinoma

A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate with a cribriform growth pattern.


Grade 1 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 2 Anorexia, CTCAE

Oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated


Grade 2 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Aspiration, CTCAE

Altered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen)


Grade 4 Lung Intra-Operative Injury, CTCAE


Parathyroid Intra-Operative Injury, CTCAE


Grade 4 Gastrointestinal Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Accelerated Phase Myeloproliferative Neoplasm

Rapid progression of a myeloproliferative neoplasm, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


Refractory Epstein-Barr Virus-Related Lymphoproliferative Disease with Primary Immunodeficiency

Epstein-Barr virus-associated lymphoproliferative disease with primary immunodeficiency that is resistant to treatment.


Overt Primary Myelofibrosis

Primary myelofibrosis characterized by reticulin or collagen fibrosis in the bone marrow. The bone marrow is usually normocellular or hypocellular. Myeloblasts account for less than 10% of the bone marrow cells. Atypical megakaryocytes are present.


Grade 3 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


Grade 1 Serum Amylase Increased, CTCAE

>ULN-1.5 x ULN


Perineal Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus.


Grade 3 Pericarditis, CTCAE

Pericarditis with physiologic consequences (e.g., pericardial constriction)


Flashing Lights, CTCAE

A disorder characterized by a sudden or brief burst of light.


Atelectasis, CTCAE

A disorder characterized by the collapse of part or the entire lung.


Grade 5 Supraventricular Tachycardia, CTCAE

Death


Grade 1 Fever Without Neutropenia, CTCAE


Left Ventricular Diastolic Dysfunction, CTCAE

An adverse event characterized by impaired functioning of the left ventricle of the heart during the diastole phase of the cardiac cycle.


Radiating Chest Pain in Sternum

The location of the radiating chest pain is in the middle of the anterior wall of the thorax, bounded by the clavicles, above, and with the cartilages of the first seven ribs, along the sides.


Reduced WAS Protein Expression

An indication that reduced expression of Wiskott-Aldrich Syndrome protein (WASP; WASp) has been detected in a sample.


Stage IIIC2 Uterine Corpus Cancer AJCC v7

Stage IIIC2 includes: T1-T3, N2, M0. T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue.  N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Grade 3 Upper Gastrointestinal Hemorrhage NOS, CTCAE


Abnormal Blood Gonadotrophin

A laboratory test result which indicates abnormal levels of gonadotrophin hormone in the blood.


Laryngeal Obstruction, CTCAE

A disorder characterized by blockage of the laryngeal airway.


Grade 4 Alkaline Phosphatase Increased, CTCAE

>20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal


Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Grade 1 Hyperuricemia, CTCAE

>ULN without physiologic consequences


Mucosal-Dominant Pemphigus Vulgaris

A subtype of pemphigus vulgaris in which lesions are predominantly found on mucosal membranes with relative sparing of cutaneous tissues.


Grade 3 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Guillain-Barre Syndrome, CTCAE

Life-threatening consequences; urgent intervention indicated; intubation


Cervical Glandular Neoplasm

A benign, malignant, or precancerous neoplasm that arises from the glandular epithelium of the cervix. Representative examples include endocervical polyp, cervical adenocarcinoma, and cervical glandular intraepithelial neoplasia.


Thromboembolic Event, CTCAE

A disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream.


Grade 5 Esophagus Stricture or Stenosis, CTCAE


Drug Exposure

Contact with drug.


Grade 4 Anorectal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Metastatic Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant

Bladder micropapillary variant urothelial carcinoma that has spread to another anatomical site.


Malignant Intracranial Neoplasm by Morphology


Retinal Tear, CTCAE

A disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters.


Lugano Classification Advanced Stage Adult Hodgkin Lymphoma AJCC v8

Advanced stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Grade 5 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IIA Cervical Cancer FIGO 2018

Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement. (FIGO 2018)


Grade 3 Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Behavioral insomnia of childhood

A childhood disorder characterized by difficulty initiating and maintaining sleep due to negative sleep associations, refusal to go to bed, and/or repeated attempts to delay bedtime.


Grade 1 Wound Infection, CTCAE

Localized, local intervention indicated


Adverse Event Associated with Pulmonary and Upper Respiratory Systems


Malignant Central Nervous System Germ Cell Tumor

A germ cell tumor that affects the central nervous system, characterized by the presence of malignant morphologic characteristics.  Representative examples include choriocarcinoma, embryonal carcinoma, and germinoma.


Hodgkin's lymphoma of CNS

A Hodgkin lymphoma that arises from the central nervous system.


Grade 2 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Laryngeal Nerve Dysfunction, CTCAE


Grade 1 Biliary Tree NOS Intra-Operative Injury, CTCAE


Grade 2 Bone Intra-Operative Injury, CTCAE


Grade 3 Aortic Injury, CTCAE

Severe symptoms; limiting self care ADL; repair or revision indicated


Grade 3 Trachea Obstruction and Stenosis, CTCAE


Grade 3 Toothache, CTCAE

Severe pain; limiting self care ADL


Vaginal Mucinous Adenocarcinoma

A rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma.


Posterior Subcapsular Cataract Grade 1

A stage of posterior subcapsular cataract characterized by 3% of the posterior capsule obscured by opacity. (Modified LOCS II)


Grade 1 Other Allergy and Immunology, CTCAE


Infant Acute Lymphoblastic Leukemia

An acute lymphoblastic leukemia that occurs in infancy.


Brachial Plexopathy, CTCAE 5.0

A disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand.


Simple Endometrial Hyperplasia without Atypia

A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is absent.


Grade 5 Fracture, CTCAE

Death


Locally Advanced Epithelioid Hemangioendothelioma

An epithelioid hemangioendothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Jejunum Intra-Operative Injury, CTCAE


Lung Thoracic Nerve Intra-Operative Injury, CTCAE


Neonatal Deformity

A congenital anatomic abnormality manifested during the neonatal period.


Grade 1 Vitreous Hemorrhage, CTCAE

Intervention not indicated


Grade 4 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cervicitis Infection, CTCAE

A disorder characterized by an infectious process involving the uterine cervix.


Breast Papillary Ductal Hyperplasia

Benign papillary proliferation within the ductal system of the breast parenchyma.


Grade 3 Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


Grade 5 Rectal Ulcer, CTCAE

Death


Somatic-Type Malignancy

A malignant non-germ cell component that typically develops secondarily within a germ cell tumor. The malignant cellular component is usually sarcomatous or carcinomatous.


Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Intraoperative Urinary Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Stage IIB Pancreatic Cancer AJCC v8

Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Postoperative Spindle Cell Nodule of the Bladder

A benign, reactive lesion of the bladder, occurring status post bladder instrumentation; histologic exam demonstrates a fascicular growth pattern of plump or elongated spindle cells infiltrating the bladder wall without atypia or necrosis.


Microinvasive Anal Carcinoma

Anal carcinoma with minimal stromal invasion.


Subgaleal hemorrhage

Bleeding between the scalp and the periosteum.


Melanoma of Unknown Primary

A melanoma which has metastasized from an unknown primary anatomic site.


Unresectable Malignant Neoplasm

A malignant neoplasm which is not amenable to surgical resection.


CTCAE v4 Grade 4

An adverse event that has life-threatening consequences; for which urgent intervention is indicated; that puts the patient at risk of death at the time of the event if immediate intervention is not undertaken.


Grade 1 Abdominal Distension, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IV Osteosarcoma AJCC v7

Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 4 Multi-Organ Failure, CTCAE

Life-threatening consequences (e.g., vasopressor dependent and oliguric or anuric or ischemic colitis or lactic acidosis)


Grade 3 Blood Gonadotrophin Abnormal, CTCAE

Severe symptoms; limiting self care ADL


Grade 2 Blood and Lymphatic System Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Neonatal apneic attack

Apnea occurring during the neonatal period.


Sneezing, CTCAE

A disorder characterized by the involuntary expulsion of air from the nose.


Locally Advanced Pancreatic Ductal Adenocarcinoma

A pancreatic ductal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IIIB Appendix Carcinoma AJCC v7

Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into subserosa or into mesoappendix.  T4: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant and/or directly invades other organs or structures.  N1: Metastasis in 1-3 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Dialysis Catheter Embolism

An obstruction of a vessel caused by a detached fragment of an indwelling dialysis catheter.


Grade 3 Erectile Dysfunction, CTCAE

Decrease in erectile function (frequency/rigidity of erections) but erectile intervention not helpful (e.g., medication or mechanical devices such as penile pump); placement of a permanent penile prosthesis indicated (not previously present)


Grade 2 Injury To Jugular Vein, CTCAE

Repair or revision not indicated


Grade 1 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Pathologic Stage 0 Cutaneous Melanoma AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 2 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Spermatic Cord Stricture or Stenosis, CTCAE


Grade 1 Central Nervous System Necrosis, CTCAE


Metastatic Bladder Squamous Cell Carcinoma

Bladder squamous cell carcinoma that has spread to another anatomical site.


Transplant-Related Squamous Cell Carcinoma

A squamous cell carcinoma that arises in a patient with a history of organ transplantation.


Refractory Anaplastic Oligodendroglioma

An anaplastic oligodendroglioma that is resistant to treatment.


Grade 5 Left Ventricular Systolic Dysfunction, CTCAE

Death


Grade 4 Abdomen Soft Tissue Necrosis, CTCAE


Reinfection

A second infection by the same pathogen that follows a period of recovery.


Immunotoxicity

Toxicity that impairs or damages the immune system.


Accessory Urethral Gland Neoplasm

A benign or malignant, primary or metastatic neoplasm affecting the accessory urethral gland.


Grade 2 Retinopathy, CTCAE

Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL


Grade 4 Heart Intra-Operative Injury, CTCAE


Grade 4 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Stage II Gallbladder Cancer AJCC v6

Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N0, M0); (T2, N0, M0); (T3, N0, M0).  T2: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, or pancreas, omentum or extrahepatic bile ducts. (AJCC 6th ed.)


Grade 3 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ampulla of Vater Undifferentiated Carcinoma

An aggressive carcinoma arising from the ampulla of Vater.  Morphologically, it is characterized by the presence of malignant epithelial cells without evidence of glandular or squamous differentiation.  Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.


Possible Adverse Event Attribution to Product or Procedure

Possible adverse event relationship to study product or procedure is defined when there is less clear temporal association between product or procedure administration and adverse event, and other etiologies of the event are also possible.


Grade 5 Wound Infection, CTCAE

Death


Clinical Stage II Retinoblastoma AJCC v8

Stage II includes: cT4a, cN0, cM0, Any H. cT4a: Radiologic evidence of retrobulbar optic nerve involvement or thickening of optic nerve or involvement of orbital tissues. cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Grade 4 Bronchopulmonary Hemorrhage, CTCAE

Life-threatening consequences; intubation or urgent intervention indicated


Peripheral Hemangioblastoma

A hemangioblastoma that arises from peripheral nerves or extraneural tissues.


Non-Ossifying Fibroma

A tumor histologically indistinguishable from, but larger than, benign fibrous histiocytoma of bone.  It usually arises from the metaphysis of long bones.


Digitalis toxicity

Acute CNS, visual, GI, and cardiac disturbances caused by an overdose of, or intolerance to, the cardiac glycoside, digitalis.


Clonal Hematopoiesis

Cellular proliferation of hematopoietic cells where a substantial proportion of the cells is derived from a single hematopoietic stem cell lineage.


Grade 1 Dry Mouth, CTCAE

Symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min


Grade 2 Uterine Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Hodgkin's Paragranuloma Involving Spleen

An obsolete term that includes cases currently classified as nodular lymphocyte predominant Hodgkin lymphoma with splenic involvement.


Stage IB1 Cervical Cancer AJCC v8

Stage IB1 includes: T1b1, Any N, M0. T1b1: Tumor with clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 4 Pancreatitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Intracranial Hemorrhage, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IIA Cervical Cancer AJCC v8

Stage IIA includes: T2a, Any N, M0. T2a: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 3 Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


Liver Radiation Injury

Radiation injury of the liver.


Grade 2 Sacral Plexus Intra-Operative Injury, CTCAE


BRCA-Associated Malignant Neoplasm

A malignant neoplasm caused by deleterious germline mutation in a gene of the BRCA family.


Grade 2 Ovarian Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 4 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Kidney Infection, CTCAE

Death


Wood Dust Exposure

Environmental or occupational exposure to granular solids generated when timber is processed, such as when it is chipped, sawed, turned, drilled or sanded.


Grade 3 Vagina Intra-Operative Injury, CTCAE


Grade 2 Neuroendocrine ACTH Deficiency, CTCAE


Grade 1 Vaginal Inflammation, CTCAE

Mild discomfort or pain, edema, or redness


Grade 3 Duodenal Fistula, CTCAE

Invasive intervention indicated


Benign Apocrine Neoplasm

A non-metastasizing neoplasm arising from the apocrine glands.


Grade 3 Conjunctiva Intra-Operative Injury, CTCAE


Non-Neoplastic Tracheal Disorder

A non-neoplastic disorder that affects the trachea.  Representative examples include tracheitis, tracheal agenesis, and tracheal atresia.


Gastroblastoma

A very rare biphasic tumor arising in the gastric muscularis propria (usually of the antrum), generally in boys and young men. It is associated with MALAT1-GLI1 gene fusion. (WHO 2019)


Grade 3 Constipation, CTCAE

Obstipation with manual evacuation indicated; limiting self care ADL


Acute synovitis

An acute inflammation of a synovial membrane. It is associated with swelling and pain in the affected area.


Cheilognathoschisis

A congenital abnormality consisting of a fissure in the midline of the lip and upper jaw.


Hemoglobin Trait

A condition in which a person is heterozygous for a globin gene, with a one normal allele and one defective allele.


Grade 5 Neonatal Intraventricular Hemorrhage, AE

An intraventricular hemorrhage adverse event in a newborn which results in death.


HIV lipodystrophy

A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the breast and cervical areas, and an accumulation of visceral fat.  It is associated with antiretroviral therapy.  Clinical presentation includes hyperlipidemia, insulin resistance, and fat atrophy of the face and limbs.


Cortical Cataract Grade 1

A stage of cortical cataract characterized by 10% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Stage I Uterine Corpus Cancer AJCC v6

Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium.  T1b: Tumor invades less than one-half of the myometrium.  T1c: Tumor invades one-half or more of the myometrium.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IIB Anal Cancer AJCC v8

Stage IIB includes: T3, N0, M0. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Mucosal Melanoma

Mucosal melanoma that has spread from its primary site to another anatomic site.


Recurrent Childhood Anaplastic Oligodendroglioma

The reemergence of anaplastic oligodendroglioma in childhood after a period of remission.


Grade 3 Confusion, CTCAE

Severe disorientation; limiting self care ADL


Spiradenocylindrocarcinoma

A carcinoma that arises in a spiradenocylindroma.


Grade 3 International Normalized Ratio of Prothrombin Time, CTCAE


Grade 2 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade Dysplasia

An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of high grade dysplasia.


Restrictive Cardiomyopathy, CTCAE

A disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility.


Grade 1 Oral Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Lithium Induced Birth Defect

Congenital abnormalities, mainly cardiovascular malformations, which develop in a fetus when the mother uses lithium medication during pregnancy.


Hematologic Toxicity

A toxicity that impairs or damages the hematologic system.


Grade 4 Jugular Vein Intra-Operative Injury, CTCAE


Metastatic Vaginal Squamous Cell Carcinoma

Vaginal squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


Platinum-Refractory Malignant Female Reproductive System Neoplasm

A malignant female reproductive system neoplasm that progresses during platinum therapy or within one month of completing the last platinum therapy.


Factor XII Inactivation

Presence of inactivating antibodies to factor XII in the blood.


Papillary cystadenoma, borderline malignancy

A serous or mucinous cystic glandular epithelial neoplasm of low malignant potential. It is characterized by the presence of atypical or malignant glandular epithelial cells forming papillary structures with an absence of stromal invasion.


Grade 1 Bladder Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Toxicity due to Psychiatric Drugs

Toxicity that develops due to the administration of psychiatric medications.


Elevated MHC Class II

A finding indicating elevated concentrations of MHC class II in a sample.


Grade 4 Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Unresectable Malignant Neoplasm

A malignant neoplasm that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


Benign Outer Hair Sheath and Infundibulum Neoplasm

A benign neoplasm occurring in the outer hair sheath and infundibulum.


Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential

A smooth muscle neoplasm that arises from any part of the female reproductive system and cannot be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings.


Grade 5 Intestinal Stoma Leak, CTCAE

Death


Lymphoma, Intermediate-Grade

An antiquated term that refers to a non-Hodgkin lymphoma with intermediate grade histologic features.


Olfactory Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the olfactory nerve (first cranial nerve).


Grade 4 Prostate Intra-Operative Injury, CTCAE


Grade 5 Cervicitis Infection, CTCAE

Death


Grade 5 Gastric Stenosis, CTCAE

Death


Grade 4 Non-Myocardial Visceral Arterial Ischemia, CTCAE


Grade 3 Euphoria, CTCAE

Severe mood elevation (e.g., hypomania)


SUR1-Associated Diabetes Mellitus

Diabetes mellitus caused by activating mutation(s) in the ABCC8 gene, encoding the sulfonylurea receptor 1 (SUR1) subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the ABCC8 gene result in hyperinsulinism.


Grade 4 Peritoneal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Fever Without Neutropenia, CTCAE


Non-Malignant Nodule

A usually circumscribed and non-metastasizing nodular mass.


Stage II Adult Diffuse Large Cell Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Grade 4 Infusion Site Extravasation, CTCAE


Stabbing Pain

An intense sensation of discomfort or distress that is sharp and feels as though a knife has penetrated an anatomical location.


Tissue Rarefaction

A morphologic finding indicating reduced tissue density.


Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22) CBFB-MYH11

An acute myeloid leukemia with monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow.  This type of acute myeloid leukemia has a favorable prognosis.  (WHO, 2001)


Grade 2 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Gastroparesis, CTCAE

Moderate symptoms; able to maintain nutrition with dietary and lifestyle modifications; may need pharmacologic intervention


Mucosal Melanoma of the Female Genital Tract

A malignant melanocytic neoplasm that arises from a mucosal site of the female genital tract.


Grade 2 Ovarian Rupture, CTCAE

Symptomatic and intervention not indicated


Grade 5 Intraoperative Arterial Injury, CTCAE

Death


Grade 2 Urinary Tract NOS Intra-Operative Injury, CTCAE


Gastrointestinal Leak Including Anastomotic Leak, CTCAE


Grade 1 Acoustic Nerve Disorder NOS, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Metastatic Extracranial Malignant Solid Neoplasm

A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread from its original site of growth to another anatomic site.


Gestational Trophoblastic Tumor by FIGO Stage


Transitional Cell Intraepithelial Neoplasia


Grade 4 Pneumonitis, CTCAE

Life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Abscess of axilla

A collection of pus that has formed in the axilla.


Malignant Lacrimal Drainage System Neoplasm

A primary or metastatic malignant neoplasm that affects the lacrimal drainage system.


Grade 2 Eczema, CTCAE

Moderate; topical or oral intervention indicated; additional medical intervention over baseline indicated


Spongioblastoma, Polar

A lesion characterized by the presence of neoplastic neuroepithelial cells with palisading nuclei. This lesion implies a morphologic growth pattern and it is not considered a clinicopathological entity.


Gastroesophageal Junction Small Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction.  It is characterized by the presence of malignant small cells.


Atrophy of breast

Involution of the breast parenchyma.


Grade 3 Vein Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8

Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Monoclonal B-Cell Lymphocytosis

A monoclonal expansion of B-lymphocytes with or without the characteristic immunophenotype of chronic lymphocytic leukemia. It precedes virtually all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma.


Hypomagnesemia, CTCAE

A disorder characterized by laboratory test results that indicate a low concentration of magnesium in the blood.


Recurrent Adenocarcinoma

An adenocarcinoma that has recurred after a period of remission.


intraepithelial glandular neoplasia of cervix

A neoplastic process that affects the glandular epithelial cells of the cervix.  There is no evidence of invasion.  It is classified as low or high grade.


Gastric Ulcer, CTCAE

A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the stomach.


Grade 4 Other Growth and Development, CTCAE


Grade 2 Extrapyramidal Disorder, CTCAE

Moderate involuntary movements; limiting instrumental ADL


External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Advanced Childhood Malignant Solid Neoplasm

A childhood malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Non-Fatal Cardiopulmonary Arrest Cause Unknown, CTCAE


Grade 3 Lymphocyte Count Increased, CTCAE


Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Penis Infection with Unknown Absolute Neutrophil Count, CTCAE


Advanced Squamous Cell Carcinoma

Squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Radiation-Related Angiosarcoma

A malignant vascular neoplasm arising in an anatomic site exposed to radiation therapy.


Grade 5 Prostate Stricture or Stenosis, CTCAE


Grade 3 Facial Pain, CTCAE

Severe pain; limiting self care ADL


Grade 2 Lingual Nerve Intra-Operative Injury, CTCAE


Nutritional Vitamin D Deficiency Rickets

Nutritional rickets due to dietary deficiency of vitamin D.


Grade 3 Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Mitral Valve Disease, CTCAE

A disorder characterized by a defect in mitral valve function or structure.


Grade 3 Ventricular Arrhythmia, CTCAE

Urgent intervention indicated


Ureteral Kinking

The folding of a ureter, which results in the impediment of urine flow.


Grade 1 Localized Edema, CTCAE

Localized to dependent areas, no disability or functional impairment


Grade 2 Lipohypertrophy, CTCAE

Covering 10-30% BSA and associated tenderness; limiting instrumental ADL


Grade 5 Depression, CTCAE

Death


Urethral caruncle

A benign, granulomatous lesion that results from the eversion of a portion of the distal urethra, most often at the posterior edge.


Metabolism and Nutrition Disorders, CTCAE


Bone Growth Limb Length Discrepancy, CTCAE


Soft Tissue NOS Intra-Operative Injury, CTCAE


Grade 4 Pharyngeal Anastomotic Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 2 Peripheral Motor Nerve NOS Intra-Operative Injury, CTCAE


Grade 3 Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


Pancreatic Precancerous Condition

A pathologic process that arises from the pancreas and has the potential to evolve into a malignant neoplasm.


Grade 2 Conduction Disorder, CTCAE

Non-urgent medical intervention indicated


Grade 5 Neutrophils and Granulocytes, CTCAE


Grade 3 Vas Deferens Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 1 Glaucoma, CTCAE

Less than 8 mmHg of elevated intraocular pressure (EIOP); no visual field deficit


Crack

A break or fissure in a structure.


Stage III Appendix Carcinoma AJCC v8

Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T3, N1, M0); (T4, N1, M0); IIIC: (Any T, N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Merkel Cell Carcinoma

The reemergence of Merkel cell carcinoma after a period of remission.


Dry Eye, CTCAE

A disorder characterized by dryness of the cornea and conjunctiva.


Acute rheumatic endocarditis

Inflammation of the endocardium in acute rheumatic heart disease.


Grade 2 Acute Vascular Leak Syndrome, CTCAE


Grade 5 Mediastinum Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Refractory Spindle Cell Sarcoma

Spindle cell sarcoma that is resistant to treatment.


Stage I Vulvar Carcinoma

Stage I includes: T1, N0, M0. T1: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.).


Gastointestinal Stoma Intra-Operative Injury, CTCAE


Hodgkin's Disease, Lymphocyte Depletion, Diffuse Fibrosis

A lymphocyte depleted Hodgkin lymphoma characterized by the presence of diffuse fibrosis and a few Hodgkin and Reed-Sternberg cells.


Grade 5 Intracranial Hemorrhage, CTCAE

Death


Refractory Ampulla of Vater Carcinoma

Ampulla of Vater carcinoma that is resistant to treatment.


Grade 3 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage II Pancreatic Cancer AJCC v6 and v7

Stage II includes: IIA (T3, N0, M0); IIB (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor limited to the pancreas 2 cm or less in greatest dimension.  T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension. T3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery.  N0: No regional lymph node metastasis. N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Visual Pathway Melanocytoma

A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve.


Grade 1 Neonatal Culture Positive Sepsis, AE

An adverse event in a newborn characterized by a positive blood culture positive; no care change indicated (e.g. contamination suspected).


Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic Fallopian Tube High Grade Serous Adenocarcinoma

Fallopian tube high-grade serous adenocarcinoma that has spread from its original site of growth to other anatomic sites.


Recurrent Childhood Acute Lymphoblastic Leukemia

The reemergence of acute lymphoblastic leukemia in childhood after a period of remission.


Grade 4 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


Appendix Intraepithelial Neoplasia

A precancerous intraepithelial neoplastic lesion that affects the appendix. It is characterized by low or high grade dysplasia of the mucosal epithelium.  There is no evidence of invasion.


Grade 4 Jejunal Obstruction, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Upper Respiratory Infection, CTCAE

A disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea).


Cat bite

A wound received from the teeth of a cat.


Grade 5 Intraoperative Neurological Injury, CTCAE

Death


Vaginal intraepithelial neoplasia

A superficial neoplastic process involving exclusively the vaginal squamous epithelium without extension to underlying tissue.  It is classified as low- or high-grade intraepithelial neoplasia.


Recurrent Sarcoma

The reemergence of sarcoma after a period of remission.


Grade 2 Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Ileum Infection with Unknown Absolute Neutrophil Count, CTCAE


Hemoglobin Increased, CTCAE

A finding based on laboratory test results that indicate increased levels of hemoglobin above normal.


Grade 1 Urethral Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Dizziness, CTCAE 5.0

A disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking.


Locally Advanced Glioma

Glioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Infective conjunctivitis

An infectious process affecting the conjunctiva.


Grade 5 Abdomen Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Surgical and Medical Procedures - Other, Specify, CTCAE


Childhood Grade III Meningioma

A grade III meningioma that occurs during childhood.


Grade 4 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 4 Somnolence, CTCAE

Life-threatening consequences; urgent intervention indicated


Benign Lymphoproliferative Disorder

A proliferation of lymphocytes without atypia seen in infections, hypersensitivity reactions or autoimmune diseases.


Grade 2 Retroperitoneum Hemorrhage, CTCAE


Bronchial Epithelial Hyperplasia

Hyperplasia of the bronchial epithelial cells.  It is often associated with squamous metaplasia.


Grade 4 Glomerular Filtration Rate, CTCAE


Grade 2 Serum Glutamic Oxaloacetic Transaminase, CTCAE


Grade 2 Eye Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Inverted Squamous Cell Papilloma

A benign epithelial neoplasm characterized by an endophytic growth, papillary pattern, and proliferation of neoplastic squamous cells without morphologic evidence of malignancy.


Refractory Endometrial Mixed Cell Adenocarcinoma

Endometrial mixed cell adenocarcinoma that is resistant to treatment.


Amenorrhea, CTCAE

A disorder characterized by the abnormal absence of menses for at least three consecutive menstrual cycles


A non-neoplastic disorder arising in an anatomic site exposed to radiation.


Refractory Malignant Solid Neoplasm

A malignant solid neoplasm that does not respond to treatment.


Unresectable Bone Sarcoma

Bone sarcoma that is not amenable to surgical resection.


Childhood Nodular Sclerosis Classic Hodgkin Lymphoma

Nodular sclerosis classic Hodgkin lymphoma occurring in childhood.


Stage IIB Ampulla of Vater Cancer AJCC v8

Stage IIB includes: T3b, N0, M0. T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Advanced Malignant Testicular Germ Cell Tumor

A malignant testicular germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Phrenic nerve lesion

Intermittent, incomplete or complete paralysis with or without tremors to any of the organs or body parts innervated by the phrenic nerve.


Proteinuria, CTCAE 5.0

A disorder characterized by laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin.


Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Delusional disorder, jealous type

A subtype of delusional disorder characterized by the central delusional theme that the individual's spouse or lover is unfaithful.


Gastroesophageal Junction Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Grade 3 Esophageal Pain, CTCAE

Severe pain; limiting self care ADL


Grade 1 Local Complication of Device and Prosthesis, CTCAE


Childhood Astrocytoma

An astrocytoma that occurs during childhood.


Advanced Large Cell Neuroendocrine Carcinoma

Large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Typhlitis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 1 Papulopustular Rash, CTCAE

Papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness


Grade 1 Anorectal Infection, CTCAE

Localized, local intervention indicated


Stage 0 Low Grade Appendix Mucinous Neoplasm (LAMN) AJCC v8

Stage 0 includes: Tis(LAMN), N0, M0. Tis(LAMN): Low-grade appendiceal mucinous neoplasm confined by the muscularis propria. Acellular mucin or mucinous epithelium may invade into the muscularis propria. T1 and T2 are not applicable to LAMN. Acellular mucin or mucinous epithelium that extends into the subserosa or serosa should be classified as T3 or T4a, respectively. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Hodgkin's disease nodular sclerosis recurrent

The reemergence of nodular sclerosis classic Hodgkin lymphoma after a period of remission.


Grade 4 Esophageal Obstruction, CTCAE

Life-threatening consequences; urgent intervention indicated


Metastatic Bladder Urachal Urothelial Carcinoma

Bladder urachal urothelial carcinoma that has spread to another anatomic site.


Stage IIIC Prostate Cancer AJCC v8

Stage IIIC includes: Any T, N0, M0, PSA: Any, Grade Group 5. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 5: Gleason Score 9 or 10, Gleason Pattern 4+5, or 5+4, or 5+5. (AJCC 8th ed.)


Grade 3 Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


Cramping Pain

A sense of discomfort or distress that is spasmodic or clenching.


Night Blindness, CTCAE

A disorder characterized by an inability to see clearly in dim light.


Grade 5 Other Renal or Genitourinary, CTCAE


Grade 3 Mucositis Oral, CTCAE

Severe pain; interfering with oral intake


Recurrent Childhood Large Cell Lymphoma

The reemergence of childhood large cell lymphoma after a period of remission.


Grade 2 Cyanosis, CTCAE

Present


Grade 3 Liver Dysfunction or Failure by Clinical Classification, CTCAE


Stage III Uterine Corpus Cancer

Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1-T3, N1/N2, M0); IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). T3b: Tumor involves vagina (direct extension or metastasis) or parametrial tissue. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Grade 2 Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Anal Fistula, CTCAE

Invasive intervention indicated


Infantile Myofibroma

A benign, localized, nodular and well-circumscribed neoplasm seen as a congenital neoplasm or in the first year of life. It is characterized by a biphasic growth pattern and is composed of small, undifferentiated mesenchymal cells associated with branching thin-walled vessels and more mature neoplastic spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma.


Radiologic Finding

Imaging results obtained through a radiology procedure.


Grade 1 Injury To Superior Vena Cava, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Vulvar Large Cell Neuroendocrine Carcinoma

A high grade neuroendocrine carcinoma that arises from the vulva. It is characterized by the presence of malignant large cells.


Grade 3 Neonatal Sinus Bradycardia, AE

An adverse event in a newborn characterized by persistent sinus bradycardia; resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention).


Grade 3 Pharyngeal Fistula, CTCAE

Invasive intervention indicated


Grade 2 Non-Myocardial Visceral Arterial Ischemia, CTCAE


Grade 4 Vascular Disorders - Other, Specify, CTCAE


Grade 3 Bronchopulmonary Hemorrhage NOS, CTCAE


BAP1-Inactivated Melanocytoma

A cutaneous melanocytoma with inactivation of BAP1, highly atypical large epithelioid cells, and marked pleomorphism.


Recurrent Malignant Female Reproductive System Neoplasm

The reemergence of a malignant female reproductive system neoplasm after a period of remission.


Grade 2 Hypophosphatemia, CTCAE

Oral replacement therapy indicated


Grade 2 Heart Intra-Operative Injury, CTCAE


Bilateral Carcinoma

A carcinoma that affects both sides of an organ in a simultaneous or non-simultaneous manner.


Obstructed labor

A physical barrier to the natural delivery of a baby.


Stage IVA Bone Cancer AJCC v8

Stage IVA includes: Any T, N0, M1a, Any G. N0: No regional lymph node metastasis. M1a: Metastasis in the lung. (AJCC 8th ed.)


Grade 4 Urinary Tract Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Neonatal Coagulation Disorder, AE

A coagulation disorder adverse event in a newborn characterized by life threatening consequences (e.g. severe pulmonary embolism, limb ischemia, hemorrhagic shock, disseminated intravascular coagulation (DIC)); requiring urgent major care changes.


Grade 4 Cataract, CTCAE

Best corrected visual acuity of 20/200 or worse in the affected eye


Fibrinogen Decreased, CTCAE

A finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen.


Lower Extremity Artery Intra-Operative Injury, CTCAE


Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Squamous cell carcinoma, small cell, nonkeratinizing

A squamous cell carcinoma composed of small atypical cells, without morphologic evidence of keratin production.


Adipose Tissue Atrophy

Shrinking of adipose tissue.


Grade 5 Depressed Level of Consciousness, CTCAE

Death


Grade 5 Myocardial Infarction, CTCAE

Death


Grade 2 Gastrointestinal Pain, CTCAE

Moderate pain; limiting instrumental ADL


Unresectable Biliary Tract Carcinoma

Biliary tract carcinoma that is not amenable to surgical resection.


Prostate Cystadenoma

A rare cystadenoma affecting the prostate gland. It is characterized by the presence of multilocular prostatic cysts.


Metastatic glioma

Glioma that has spread from its original site of growth to another anatomic site.


Poor Prognosis Metastatic Gestational Trophoblastic Tumor

Metastatic gestational trophoblastic tumor in which risk factors are present.


Hodgkin Lymphoma During Pregnancy

Hodgkin lymphoma that occurs during pregnancy.


Vaginal Adenocarcinoma of Skene Gland Origin

A rare vaginal adenocarcinoma arising from the Skene gland. It is characterized by morphological and immunohistochemical features similar to prostate adenocarcinoma.


Thoracic meningomyelocele

A congenital abnormality in the thoracic region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Adenocarcinoma of the prostate stage IV

Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


Central Nervous System Hamartoma

A hamartoma that occurs in the central nervous system.


Grade 3 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Advanced Malignant Solid Neoplasm

A malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Dermatitis caused by substance taken internally

Dermatitis caused by an allergic reaction to an unspecified ingested substance.


Advanced Fibrosarcoma

Fibrosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Bladder Stricture or Stenosis, CTCAE


Necrotic tumor

A neoplasm characterized by focal or diffuse tumor cell necrosis.


Dialysis Catheter Obstruction

Blockage of a dialysis catheter by a thrombus or other substance.


Cutaneous Erdheim-Chester Disease

Erdheim-Chester disease that affects the skin.


Grade 5 Jejunal Hemorrhage, CTCAE

Death


Grade 3 Pharyngeal Mucositis, CTCAE

Severe pain; unable to adequately aliment or hydrate orally; limiting self care ADL


Grade 4 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IIIC Fallopian Tube Cancer AJCC v7

Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0).  T3c: Peritoneal metastasis outside the pelvis and more than 2 cm in diameter.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Congenital Varicella Zoster Infection

An infection, characterized by the rash of chickenpox or shingles, that is caused by the varicella-zoster virus transmitted directly from the mother to the fetus or neonate during late pregnancy or childbirth.


Grade 3 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Plasmacytic Hyperplasia Post-Transplant Lymphoproliferative Disorder

An early post-transplant lymphoproliferative lesion characterized by plasmacytic proliferation and architectural preservation of the involved tissues.  It often regresses either spontaneously or after reduction in immunosuppression.  The immunoglobulin genes are not rearranged.  In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion.


Grade 2 Pulmonary Hypertension, CTCAE

Moderate dyspnea, cough; requiring evaluation by cardiac catheterization and medical intervention


Hodgkin's disease nodular sclerosis stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 1 Oral Dysesthesia, CTCAE

Mild discomfort; not interfering with oral intake


Grade 4 Reproductive System and Breast Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Retroperitoneal abscess

An abscess that is located in the abdominal cavity posterior to the peritoneum.


Infusion Related Reaction, CTCAE

A disorder characterized by adverse reaction to the infusion of pharmacological or biological substances.


Grade 3 Gingiva Intra-Operative Injury, CTCAE


Grade 3 Otitis Media, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Cheilitis, CTCAE

Severe symptoms; limiting self care ADL; intervention indicated


Dental and Teeth and Peridontal Pain, CTCAE


Confusion, Post-Ictal

A period of confusion following a seizure in which the patient does not respond appropriately despite appearing awake.


Grade 1 Uterine Fistula, CTCAE

Asymptomatic


Hemorrhoidal Hemorrhage, CTCAE

A disorder characterized by bleeding from the hemorrhoids.


Grade 4 Lingual Nerve Intra-Operative Injury, CTCAE


Unresectable Transitional Cell Carcinoma

A transitional cell carcinoma which is not amenable to surgical resection.


Grade 2 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Irregular Menstruation, CTCAE

A disorder characterized by a change in cycle or duration of menses from baseline.


Grade 1 Gynecomastia, CTCAE

Asymptomatic


Congenital Intrahepatic Biliary Atresia

A congenital disorder characterized by blockage or absence of the intrahepatic bile ducts.


Grade 3 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Cytomegalovirus Infection

A cytomegalovirus infection that has recurred after a period of remission.


Grade 2 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Lymphedema-Related Fibrosis, CTCAE


Grade 4 Intestinal Stoma Leak, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Pulmonary Fibrosis, CTCAE

Severe hypoxia; evidence of right-sided heart failure; radiographic pulmonary fibrosis >50-75%


Grade 2 Sinus Pain, CTCAE

Moderate pain; limiting instrumental ADL


Unresectable Angiosarcoma

An angiosarcoma that is not amenable to surgical resection.


Reactive Epithelial Hyperplasia of the Ciliary Body

An increase in cell number and volume of the ciliary epithelium, usually in response to injury. (WHO 2018)


Grade 5 Cecum or Appendix Hemorrhage, CTCAE


Lacrimal Drainage System Adenocarcinoma

An adenocarcinoma that arises from the lacrimal sac or nasolacrimal duct.


Grade 5 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Supraventricular Arrhythmia NOS, CTCAE


Refractory Epithelioid Malignant Peripheral Nerve Sheath Tumor

An epithelioid malignant peripheral nerve sheath tumor that does not respond to treatment.


Grade 4 Laryngitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Rash Maculo-Papular, CTCAE

Macules/papules covering >30% BSA with moderate or severe symptoms; limiting self care ADL


Hyperglycemia, CTCAE

A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance.


No Cardiac Valve Regurgitation

No evidence of any retrograde blood flow through the valve(s) in the heart. (ACC)


Lacrimal Drainage System Inverted Papilloma

A benign neoplasm of the lacrimal drainage system characterized by an inverted/endophytic or mixed growth pattern. It is the most common epithelial neoplasm of the lacrimal drainage system. (WHO 2018)


A hepatocellular adenoma caused by activating mutations of beta-catenin.  It is characterized by the presence of nuclear atypia and absence of inflammation or steatosis.  There is an increased risk of malignant transformation.


Grade 3 Periventricular Leukomalacia, AE

An adverse event in a newborn characterized by periventricular echodensities, evolving in to extensive cystic periventricular lesions; or densities extending in to the deep white matter.


Grade 3 Treatment Related Secondary Malignancy, CTCAE

Non life-threatening secondary malignancy


Ancylostomiasis due to Ancylostoma duodenale

Ancylostomiasis that is caused by infection by Ancylostoma Duodenale.


Grade 3 Nystagmus, CTCAE

Severe symptoms; limiting self care ADL


Grade 3 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Childhood Hodgkin Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Grade 2 Aortic Valve Disease, CTCAE

Asymptomatic; moderate regurgitation or stenosis by imaging


Grade 5 Sinus Disorder, CTCAE

Death