Necrotizing granulomatous inflammation

A granuloma that contains areas of necrosis.  The majority of cases are of infectious origin.


Grade 3 Gastric Stenosis, CTCAE

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Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Delirium, CTCAE

A disorder characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Usually, it is a reversible condition.


Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Partial Thromboplastin Time, CTCAE


Squamous cell papilloma of eyelid

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A papilloma that arises from the eyelid. It is composed of squamous cells and is characterized by the presence of an acanthotic epithelium with hyperkeratosis and papillary projections with an inner fibrovascular core. It is the most common benign epithelial tumor of eyelid. It usually affects middle-aged or older adults.


Stomach Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Metabolic or Respiratory Acidosis, CTCAE


Forced Expiratory Volume Decreased, CTCAE

A finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds.


Ureter Cancer by AJCC v8 Stage

A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. (from AJCC 8th Ed.)


Lymphoma by Working Formulation (Antiquated)


Grade 4 Alanine Aminotransferase Increased, CTCAE

>20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal


Childhood Acute Leukemia

An acute leukemia that occurs during childhood.


Gastric Poorly Cohesive Adenocarcinoma

An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.  This category includes signet ring cell adenocarcinomas, adenocarcinomas that are composed of malignant cells resembling lymphocytes and histiocytes, and adenocarcinomas that are composed of malignant cells with deeply eosinophilic cytoplasm.


Grade 1 Photosensitivity, CTCAE

Painless erythema and erythema covering <10% BSA


Stage IIIA Gastric Carcinoma

Stage IIIA includes: (T4a, N1, M0); (T3, N2, M0); (T2, N3, M0).  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Periventricular Leukomalacia, AE

An adverse event in a newborn characterized by a form of cerebral white matter injury usually seen in preterm infants that is characterized by necrotic degeneration or gliosis of white matter adjacent to the cerebral ventricles that may evolve into focal cysts.


Expected Adverse Event

Any adverse event associated with a medical product or procedure, whose nature and severity have been previously observed, identified in nature, severity, or frequency, and documented in the investigator brochure, investigational plan, protocol, current consent form, scientific publication, or in other relevant and reliable document. The old term Side Effect is retired and should not be used.


Grade 3 Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Irritability, CTCAE

A disorder characterized by an abnormal responsiveness to stimuli or physiological arousal; may be in response to pain, fright, a drug, an emotional situation or a medical condition.


Grade 3 Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


Stage III Bone Sarcoma AJCC v7

Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 5 Pulmonary Fibrosis, CTCAE

Death


Grade 3 Spinal Cord Intra-Operative Injury, CTCAE


Grade 2 Chest Pain - Cardiac, CTCAE

Moderate pain; pain on exertion; limiting instrumental ADL; hemodynamically stable


Mitochondrial enzyme deficiency

A constellation of disorders whose common thread is the insufficient quantity of one or more mitochondrial enzymes.


Grade 2 Ear Pain, CTCAE

Moderate pain; limiting instrumental ADL


Stage IIIC1 Cervical Cancer AJCC v9

Stage IIIC1 includes: TX, T0, T1-3, N1, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. M0: No distant metastasis. (from AJCC 9th Ed.)


Low Grade Lymphoma (neoplasm)

An antiquated term that refers to a non-Hodgkin lymphoma with low grade histologic features.


Grade 2 Infertility and Sterility, CTCAE


Grade 2 Central Nervous System Necrosis, CTCAE

Moderate symptoms; corticosteroids indicated


Radiation-Induced Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is the result of exposure to ionizing radiation.


Grade 3 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Duodenal Obstruction, CTCAE

A disorder characterized by blockage of the normal flow of stomach contents through the duodenum.


Grade 2 Testosterone Deficiency, CTCAE

Replacement therapy initiated


Angiosarcoma NCI Grade 2

An angiosarcoma with less than 15% necrosis.


Grade 3 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Facial Nerve Disorder, CTCAE

Moderate symptoms; limiting instrumental ADL


Stage IIA Cervical Cancer AJCC v7

Stage IIA includes: IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0).  T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Serious Adverse Event

Any expected or unexpected adverse event, related or unrelated to the intervention, occurring at any agent dose, any phase of product or procedure testing, that results in any of the following outcomes: death, a life-threatening adverse event, requires inpatient hospitalization (not required as part of the treatment) or prolongation of existing hospitalization, a persistent or significant disability or incapacity, or cancer, or a congenital anomaly or birth defect. Important medical events that may not result in the listed outcomes may be considered as serious when, based upon appropriate medical judgment, they represent significant hazards or potentially serious harm to the research subject or others and may require medical intervention to prevent one of the outcomes listed in this definition.


Grade 2 Uterine Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Grade 3 Radiculitis, CTCAE

Severe symptoms; limiting self care ADL


Grade 5 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pathologic Stage I Cutaneous Melanoma AJCC v8

Stage I includes: IA: (T1a, N0, M0); (T1b, N0, M0); IB: (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Acute rheumatic pericarditis

Inflammation of the pericardium in acute rheumatic heart disease.


Squamous Cell Carcinoma of Unknown Primary

A squamous cell carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified.


Grade 2 Proptosis and Enophthalmos, CTCAE


Malignant Abdominal Neoplasm

A primary or metastatic malignant neoplasm that affects the organs and structures of the abdomen.


Grade 2 Papulopustular Rash, CTCAE

Papules and/or pustules covering 10-30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL; papules and/or pustules covering > 30% BSA with or without mild symptoms


Localized Gallbladder Carcinoma

A carcinoma that arises from the gallbladder and it has not spread to other anatomic sites.


Stage I Pancreatic Cancer AJCC v6 and v7

Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0).  T1: Tumor limited to the pancreas 2 cm or less in greatest dimension.  T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Grade 2 Urinary Tract Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cotton or Jute Dust Exposure

Environmental, occupational, or consumer-based exposure to airborne cotton or jute fibers created during the manufacture, processing, or handling of these materials.


Grade 1 Trochlear Nerve Disorder, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Transitional cell cancer of the renal pelvis and ureter localized

A transitional cell carcinoma of the renal pelvis or ureter confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


Grade 3 Urostomy Leak, CTCAE

Severe symptoms; invasive intervention indicated


Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular or squamous differentiation and giant cells resembling osteoclasts.


Non-Neoplastic Ureter Disorder

A non-neoplastic disorder affecting the ureter.


Grade 5 Portal Hypertension, CTCAE

Death


Tumor contained within organ capsule

A neoplasm surrounded by a fibrous capsule.


Childhood Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for childhood Hodgkin lymphoma based on the Ann Arbor classification criteria.


Lung Infection, CTCAE

A disorder characterized by an infectious process involving the lungs, including pneumonia.


Grade 3 Serum Glutamic Pyruvic Transaminase, CTCAE


histiocytic sarcoma of central nervous system

Rare involvement of the central nervous system by histiocytic sarcoma.


Grade 2 Rectal Stenosis, CTCAE

Symptomatic; altered GI function


Grade 5 Hepatobiliary Disorders - Other, Specify, CTCAE

Death


Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


Grade 3 Somnolence, CTCAE

Obtundation or stupor


Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pancreatic carcinoma non-resectable

Carcinoma of the pancreas that is not amenable to surgical removal.


Grade 2 Flatulence, CTCAE

Moderate; persistent; psychosocial sequelae


Metastatic Malignant Neoplasm in the Lacrimal Drainage System

A malignant neoplasm that has spread from its original site of growth to the lacrimal drainage system.


Metachronous Malignant Neoplasm

A malignant tumor that arises at a site separate from another, primary malignant tumor in the same anatomic system.  It is not clear if metachronous malignant neoplasms represent new primary tumors or metastatic disease.  Examples include metachronous osteosarcoma of the bones that develops in patients with known primary bone osteosarcoma, and metachronous Wilms' tumor that affects the opposite kidney in patients with a history of Wilms' tumor.


Locally Advanced Vulvar Carcinoma

Vulvar carcinoma that has spread to nearby tissues or lymph nodes.


Resectable Glioma

A glioma that is amenable to surgical resection.


Vulvar Germ Cell Tumor

A rare germ cell tumor that arises from the vulva.


Subgaleal Hemorrhage Related to Birth

Bleeding in the potential space between the skull periosteum and the scalp galea aponeurosis of a newborn infant due to shearing forces on the tentorium and deep venous system during labor and delivery.


High Grade Fever

Body temperature of 104 degrees Fahrenheit (40 degrees Celsius) or higher.


Neuroendocrine breast tumor

A well-differentiated neuroendocrine neoplasm that arises from the breast. It may be classified as G1 (low grade) or G2 (intermediate grade) neuroendocrine tumor.


Grade 1 Hemoglobinuria, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Atypical Gastric Lymphoid Hyperplasia

An atypical lymphoid hyperplasia involving the gastric mucosa.


Grade 5 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Bronchial Obstruction, CTCAE

Death


Grade 2 Dry Skin, CTCAE

Covering 10-30% BSA and associated with erythema or pruritus; limiting instrumental ADL


Grade 4 Hepatobiliary Disorders - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Unilateral Anophthalmos

A rare congenital abnormality characterized by the complete absence of ocular tissue in one orbit.


46,XX Ovotesticular Difference of Sex Development

The presence of ovarian and testicular tissue in the an individual with 46,XX karyotype. The anatomical expression of this condition is variable.


Childhood Overweight

A condition in which a child's body mass index (BMI) falls at or above the 85th percentile, but below the 95th percentile based on the normative values for the age and sex of the reference population.


Grade 1 Metabolic or Respiratory Acidosis, CTCAE


Infant Irritability, AE

An adverse event in a newborn characterized by crying easily and difficulty consoling.


Stage IA Esophageal Adenocarcinoma AJCC v7

Stage IA includes: T1, N0, M0, G1-2, X. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated. GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Grade 1 Small Bowel Perforation NOS, CTCAE


Grade 2 Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Appendix Neuroendocrine Tumor AJCC v8

Stage IV includes: (T1, N0, N1, M1); (T2, N0, N1, M1); (T3, N0, N1, M1); (T4, N0, N1, M1). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm but less than or equal to 4 cm. T3: Tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. T4: Tumor perforating the peritoneum or directly invading other adjacent organs or structures (excluding direct mural extension to adjacent subserosa of adjacent bowel), e.g., abdominal wall and skeletal muscle. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Grade 1 Vaccination Complication, CTCAE

Mild pain; erythema 2.5-5cm; induration/swelling 2.5-5cm; does not interfere with activity


Grade 5 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Vasogenic Edema

Edema that is characterized by increased permeability of capillary endothelial cells.


Grade 2 Alanine Aminotransferase Increased, CTCAE

>3.0-5.0 x ULN if baseline was normal; >3.0-5.0 x baseline if baseline was abnormal


Metastatic small cell carcinoma

A small cell neuroendocrine carcinoma that has metastasized from its original site of growth to another anatomic site.


Grade 2 Hepatic Vein Intra-Operative Injury, CTCAE


Stevens-Johnson Syndrome, CTCAE

A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.


Grade 4 Cranial Nerve IX Neuropathy, CTCAE


Edema Limbs, CTCAE

A disorder characterized by swelling due to excessive fluid accumulation in the upper or lower extremities.


Grade 3 Hepatic Vein Intra-Operative Injury, CTCAE


Grade 2 Jejunum Intra-Operative Injury, CTCAE


Granulosa cell-theca cell tumor

A general term used to describe sex cord-stromal tumors characterized by the presence of granulosa cells in a thecomatous/fibrothecomatous background.


Grade 1 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Retinal Vascular Disorder, CTCAE

Retinal vascular disorder without neovascularization


Grade 4 Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Pharyngeal Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Eye Infection, CTCAE

A disorder characterized by an infectious process involving the eye.


Grade 3 Fallopian Tube Intra-Operative Injury, CTCAE


Gastroesophageal Junction Large Cell Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction.  It is characterized by the presence of malignant large cells.


Pancreatic Poorly Differentiated Ductal Adenocarcinoma

A pancreatic ductal adenocarcinoma characterized by the presence of small and irregular malignant glandular structures, solid sheets of malignant cells, and single malignant cells.


T-Cell Large Granular Lymphocyte Leukemia, Common Variant

T-cell large granular lymphocyte leukemia defined by the presence of CD3-positive, CD8-positive, and T-cell receptor alpha-beta-positive cytotoxic T-cells.


Grade 4 Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


Meningitis, CTCAE

A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord.


Grade 3 Breast Intra-Operative Injury, CTCAE


Gastric Cancer by AJCC v7 Stage

A term that refers to the staging of gastric carcinoma according to the American Joint Committee on Cancer, 7th edition.


Lymphocele, CTCAE

A disorder characterized by a cystic lesion containing lymph.


Radiculoneuropathy

Spontaneous degeneration of the spinal cord and peripheral nerves characterized by myelin sheath vacuolation, Wallerian degeneration and intramyelinic space infiltration by macrophages.


Unspecified deformity of forearm, excluding fingers

Any anatomic abnormality of the arm located between the elbow and the wrist.


Grade 4 Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Muscular Dystrophy Secondary to Mitochondrial Disorder

A muscular dystrophy that was caused by a primary mitochondrial disorder.


Locally Advanced Adenocarcinoma

Adenocarcinoma that has spread to nearby tissues or lymph nodes.


Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Gallbladder Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.


Radiation Overdose

A higher than intended cumulative dose of radiation to a single field.


External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Intraoperative Neurological Injury

Damage to any part of the nervous system during a surgical procedure.


Grade 3 Cranial Nerve V Motor Intra-Operative Injury, CTCAE


Grade 2 Hyperthyroidism, CTCAE

Symptomatic; thyroid suppression therapy indicated; limiting instrumental ADL


Intermediate Bone Neoplasm

A locally aggressive or rarely metastasizing neoplasm that arises from the bone.


Grade 4 Injury To Carotid Artery, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 1 Amnesia, CTCAE

Mild; transient memory loss


Grade 5 Abdomen Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Criminal injury

Trauma resulting from illegal activity.


Unresectable Peritoneal Malignant Mesothelioma

Peritoneal malignant mesothelioma that is not amenable to surgical resection.


Grade 1 Anus Stricture or Stenosis, CTCAE


Fuchs' adenoma

A benign proliferation of the pars plicata epithelium of the ciliary body. It is associated with aging..


Grade 2 Heart Failure, CTCAE

Symptoms with moderate activity or exertion


Grade 2 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Adverse Event Associated with the Hepatobiliary System and Pancreas


Grade 2 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Embolism, Amniotic Fluid

Acute hypotension or cardiac arrest, acute hypoxia or coagulopathy in the absence of any other potential explanation related to the presence of amniotic fluid or the fetal debris within the maternal vascular system during the antepartum or intrapartum period.


Grade 5 Enterocolitis Infectious, CTCAE

Death


Myeloid Neoplasms with Germline Predisposition

A term that refers to myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, and acute myeloid leukemias that are associated with germline mutations and are familial.


Grade 3 Intraoperative Endocrine Injury, CTCAE

Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Stage IIIA Vulvar Cancer AJCC v7

Stage IIIA includes: (T1/T2, N1a/N1b, M0); T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N1a: Vulvar cancer with one or two lymph node metastasis each measuring 5 mm or less.  N1b: Vulvar cancer with one lymph node metastasis measuring 5 mm or greater.  M0: No distant metastasis.  (AJCC 7th ed.)


Malignant Testicular Sertoli Cell Tumor

A Sertoli cell tumor that arises from the testis and is characterized by nuclear pleomorphism, increased mitotic activity and necrotic changes.  Metastases may be present at diagnosis.


Grade 2 Laryngeal Stenosis, CTCAE

Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


Grade 4 External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Malignant Germ Cell Tumor

The reemergence of a malignant germ cell tumor after a period of remission.


Grade 3 Jejunal Stenosis, CTCAE

Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Injury, Poisoning and Procedural Complications, CTCAE


Laryngeal Mucositis, CTCAE

A disorder characterized by ulceration or inflammation involving the mucous membrane of the larynx.


Congenital Platelets Abnormality

A group of rare inherited platelet disorders that involve abnormalities of platelet function or platelet production and that usually cause moderate to severe bleeding problems.


Grade 4 Hyperlipidemia, CTCAE

Life-threatening consequences


Grade 4 Eye NOS Intra-Operative Injury, CTCAE


Grade 4 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Defective Alpha Heavy Chain Present

An indication that cells expressing a mutated or defective form of immunoglobulin heavy chain alpha have been detected in a sample.


Lugano Classification Childhood Hodgkin Lymphoma by AJCC v8 Stage

A staging system for childhood Hodgkin lymphomas based on the Lugano classification criteria. Staging for childhood Hodgkin lymphoma is the same as for the adult counterpart. (from AJCC 8th Ed.)


Hypotension, CTCAE

A disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment.


Adult Angiosarcoma

An angiosarcoma occurring in the adult population.


Grade 2 Neuralgia, CTCAE

Moderate pain; limiting instrumental ADL


neoplasm of optic chiasm

A benign or malignant neoplasm that affects the optic chiasm.


Grade 1 Pyramidal Tract Syndrome, CTCAE

Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Respiratory Tract Hemorrhage NOS, CTCAE


Abscess of pituitary

An inflammatory or infectious process in the pituitary gland characterized by a circumscribed, walled collection of purulent material.


Duodenal Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the duodenum.


High Level of Hyaluronic Acid

A finding indicating high concentrations of hyaluronic acid in a sample.


Grade 1 Bronchus Intra-Operative Injury, CTCAE


Metastatic Conjunctival Melanoma

Conjunctival melanoma that has spread from its original site of growth to another anatomic site.


Grade 2 Infantile Apnea, AE

An adverse event in a newborn characterized by apnea responsive to stimulation or intermittent fraction of inspired oxygen (FiO2) increase.


Assault by sharp object

A physical attack with a pointed object.


Grade 4 Voice Changes and Dysarthria, CTCAE


Localized Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

An undifferentiated high grade pleomorphic sarcoma of bone that occurs in adulthood and has not spread to other anatomic sites.


Grade 1 Wound Dehiscence, CTCAE

Incisional separation, intervention not indicated


Grade 4 Anus Intra-Operative Injury, CTCAE


Grade 5 Hemolysis, CTCAE

Death


Refractory Melanoma

Melanoma that does not respond to treatment.


Lugano Classification Hodgkin Lymphoma by AJCC v8 Stage

A staging system for Hodgkin lymphomas based on the Lugano classification criteria. Staging for childhood Hodgkin lymphoma is the same as for the adult counterpart. (from AJCC 8th Ed.)


Central Nervous System Paraganglioma

An extra-adrenal paraganglioma arising from the central nervous system.


Nuclear Cataract Grade 4

A stage of nuclear sclerotic cataract marked by severe yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Tuberculous abscess

An abscess resulting from infection by Mycobacterium tuberculosis.


An epithelioid hemangioendothelioma that has spread from its original site of growth to another anatomic site.


Grade 5 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Hypercalcemia, CTCAE

Death


Papillary carcinoma in situ

An epithelial neoplasm with a papillary growth pattern in which the malignant cells are confined to the epithelium, without evidence of invasion.


Grade 3 Larynx Obstruction and Stenosis, CTCAE


Grade 4 Surgical and Medical Procedures - Other, Specify, CTCAE

Life-threatening consequences; urgent intervention indicated


Unresectable Prostate Carcinoma

Prostate carcinoma that is not amenable to surgical resection.


Grade 4 Spleen Intra-Operative Injury, CTCAE


Grade 4 Rectal Necrosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Olfactory neurogenic tumor

A rare, benign (olfactory neurocytoma) or malignant (olfactory neuroblastoma) neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity.


Grade 2 Nodular Sclerosis Classic Hodgkin Lymphoma

Nodular sclerosis Hodgkin lymphoma in which at least 25% of the tumor nodules contain increased numbers of Reed-Sternberg cells.


Grade 5 Multi-Organ Failure, CTCAE

Death


Metastatic malignant neoplasm to lacrimal gland

A malignant neoplasm that has spread from its original site of growth to the lacrimal gland.


Malignant Fundus Neoplasm

A primary or metastatic malignant neoplasm that affects the gastric fundus.


Grade 2 Right Ventricular Dysfunction, CTCAE

Symptoms with moderate activity or exertion


Elevated Human Chorionic Gonadotropin

A finding indicating elevated concentrations of human chorionic gonadotropin in a sample.


Stage I Extragonadal Non-Seminomatous Germ Cell Tumor


Stage IIB Fallopian Tube Cancer AJCC v6 and v7

Stage IIB includes: T2b, N0, M0.  T2b: Extension to other pelvic structures.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Grade 3 Small Intestinal Obstruction, CTCAE

Hospitalization indicated; invasive intervention indicated; limiting self care ADL


Polyostotic Langerhans cell histiocytosis

Langerhans cell histiocytosis presenting with multiple sites of involvement.


Stage III Acral Lentiginous Melanoma AJCC v7

Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Diencephalic Glioblastoma

A glioblastoma that occurs in the diencephalon.


Grade 5 Hypothyroidism, CTCAE

Death


Nightmare Disorder

A sleep disorder characterized by the repeated occurrence of frightening dreams which precipitate awakenings from sleep; on awakening, the individual becomes fully alert and oriented and has detailed recall of the nightmare, which usually involves imminent danger or extreme embarrassment to the individual.


Retinoblastoma, spontaneously regressed

An archaic term that refers to benign, non-progressive retinal lesions in patients with mutation of the RB1 gene.


Grade 4 Nasopharynx Intra-Operative Injury, CTCAE


Elevated CEA

A laboratory test result indicating the presence of an increased level of the tumor-associated antigen (TAA) CEA in a biological sample.


Grade 3 Edema of the Head and Neck, CTCAE


Neonatal hyperglycemia

Blood glucose concentration above the upper limit of established reference ranges in a newborn.


Atypical Melanocytic Nevus of Genital Type

A small, well circumscribed melanocytic neoplasm that arises from the vulva and affects women in their reproductive years. It is characterized by the presence of junctional nests of melanocytes. Some of the superficial melanocytes show atypia. During pregnancy the atypical melanocytic changes may appear more prominent. This neoplasm is not associated with the presence of dysplastic nevi in other anatomic areas.


Refractory Prostate Carcinoma

Prostate carcinoma that is resistant to treatment.


Recurrent Female Reproductive System Carcinoma

The reemergence of female reproductive system carcinoma after a period of remission.


Grade 2 Photosensitivity, CTCAE

Tender erythema covering 10-30% BSA


Lugano Classification Stage III Childhood Hodgkin Lymphoma AJCC v8

Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Therapy-Related Toxicity - Unacceptable to Patient

Indicates that a toxicity adverse effect has been experienced by a patient, and it is severe enough for the patient to discontinue the treatment.


Grade 2 Oral Cavity Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 3 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gastric Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the gastric wall.


Grade 2 Bronchial Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Eating disorder symptom

Abnormal eating behaviors, including binge eating, compulsive eating, emotional eating, night eating, and self-induced vomiting, though not at a level that rises to the diagnosis of eating disorder.


Transthyretin amyloid cardiomyopathy

Cardiomyopathy resulting from the deposition of misfolded transthyretin. The condition can be classified by the presence (hereditary transthyretin amyloid) or absence (wild-type transthyretin amyloid) of mutation(s) in the TTR gene, encoding transthyretin.


Grade 3 Delirium, CTCAE

Severe and acute confusional state; limiting self care ADL; urgent intervention indicated; new onset


Adenocarcinoma of the prostate metastatic

An adenocarcinoma that arises from the prostate gland and has spread to other anatomic sites.


Bladder Neuroendocrine Neoplasm

A neuroendocrine neoplasm that arises from the bladder.


Grade 5 Myelitis, CTCAE

Death


Stage IB Cervical Cancer AJCC v8

Stage IB includes: T1b, Any N, M0. T1b: Tumor with clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. It includes all macroscopically visible lesions, even those with superficial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 5 Hemolytic Uremic Syndrome, CTCAE

Death


Recurrent Intermediate Grade Adult Non-Hodgkin's Lymphoma


Grade 1 Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Venous Stroke

Ischemic or hemorrhagic stroke resulting from cerebral venous thrombosis.


Fetus Small for Gestational Age with Oligohydraminos

A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and shows evidence of oligohydramnios.


Cervical Cancer by FIGO Stage 2009

A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2009.


Non-Neoplastic Central Nervous System Disorder


Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Rectal Anastomotic Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 2 Edema of the Trunk and Genital Area, CTCAE


Grade 2 Viremia, CTCAE

Moderate symptoms; medical intervention indicated


Grade 5 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Vascular disorder of intestine

A non-neoplastic or neoplastic vascular disorder that affects the intestines.


Cerebellar sarcoma

An obsolete term referring to desmoplastic medulloblastoma.


Grade 4 Left Ventricular Diastolic Dysfunction, CTCAE


Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gastric Non-Neoplastic Polyp

A non-neoplastic polyp that arises from the stomach.  This category includes hyperplastic polyps and hamartomatous polyps.


Grade 4 Hypohidrosis, CTCAE

Heat stroke


Recurrent Childhood Diffuse Astrocytoma

The reemergence of diffuse astrocytoma in childhood after a period of remission.


Grade 5 Vaginal Perforation, CTCAE

Death


Grade 2 Pulmonary Artery Intra-Operative Injury, CTCAE


Nail Loss, CTCAE

A disorder characterized by loss of all or a portion of the nail.


Stage IIIA Esophageal Cancer AJCC v7

Stage IIIA includes: For squamous cell carcinoma: (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 4 Pulmonary Vein Intra-Operative Injury, CTCAE


Stage IB2 Cervical Cancer AJCC v8

Stage IB2 includes: T1b2, Any N, M0. T1b2: Tumor with clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Radiation anemia

Anemia arising due to radiation therapy.


Grade 1 Cranial Nerve VI Neuropathy, CTCAE


Seroma, CTCAE

A finding of tumor-like collection of serum in the tissues.


Grade 1 Intraoperative Arterial Injury, CTCAE

Primary repair of injured organ/structure indicated


Grade 3 Vaginal Inflammation, CTCAE

Severe discomfort or pain, edema, or redness; limiting self care ADL; small areas of mucosal ulceration


Invasive listeriosis

A bacterial infection by Listeria monocytogenes in a sterile body compartment.


Grade 5 Other Allergy and Immunology, CTCAE


Stage 0 Pancreatic Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. This includes high-grade pancreatic intraepithelial neoplasia (PanIn-3), intraductal papillary mucinous neoplasm with high-grade dysplasia, intraductal tubulopapillary neoplasm with high-grade dysplasia, and mucinous cystic neoplasm with high-grade dysplasia.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Defects in Intrinsic and Innate Immunity

A group of diseases or disorders caused by genetic defects within the immune system, comprised by: Mendelian susceptibility to mycobacterial disease (MSMD); Epidermodysplasia verruciformis (HPV); Predisposition to severe viral infection; Herpes simplex encephalitis (HSE); Predisposition to invasive fungal diseases; Predisposition to mucocutaneous candidiasis; TLR signaling pathway deficiencies with bacterial susceptibility; and other inborn errors of immunity related to nonhematopoietic tissues.


Lymphocyte-Depleted Classic Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for lymphocyte-depleted classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Grade 1 Depression, CTCAE

Mild depressive symptoms


Grade 3 Pyramidal Tract Dysfunction, CTCAE


Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE


Metastatic Unresectable Sarcoma

A metastatic sarcoma that is not amenable to surgical resection.


Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Grade 4 Penile Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 3 Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Fever, CTCAE

A disorder characterized by elevation of the body's temperature above the upper limit of normal.


Grade 3 Acoustic Nerve Disorder NOS, CTCAE

Severe symptoms; limiting self care ADL


Locally Advanced Esophageal Adenocarcinoma

Esophageal adenocarcinoma that has spread to nearby tissues or lymph nodes.


Grade 5 Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IIA Digestive System Neuroendocrine Tumor AJCC v7

Stage IIA includes: T2, N0, M0.  T2: Stomach/ duodenum /jejunum/ileum: tumor invades muscularis propria or is more than 1 cm in size; ampulla: tumor is more than 1 cm in size; colon or rectum: tumor invades muscularis propria or is more than 2 cm in size with invasion of lamina propria or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Electrocardiogram T Wave Abnormal, CTCAE

A disorder characterized by Electrocardiogram T wave amplitude changes.


Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis

A myelodysplastic/myeloproliferative neoplasm with morphologic and clinical characteristics of refractory anemia with ring sideroblasts, marked thrombocytosis, and abnormal megakaryocytes.


Metastatic Appendix Adenocarcinoma

Appendix adenocarcinoma that has spread from its original site of growth to another anatomic site.


Grade 3 Vitreous Hemorrhage, CTCAE

Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL; vitrectomy indicated


Grade 4 Cranial Nerve I Intra-Operative Injury, CTCAE


Hodgkin's disease nodular sclerosis stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Grade 1 Hypoalbuminemia, CTCAE

<LLN-3 g/dL; <LLN-30 g/L


Grade 1 Lymphedema-Related Fibrosis, CTCAE


Grade 1 Gum Infection, CTCAE

Local therapy indicated (swish and swallow)


Grade 2 Hypernatremia, CTCAE

>150-155 mmol/L; intervention initiated


Ann Arbor Stage III AIDS-Related Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Pancreatic Neuroendocrine Microtumor

A non-functioning pancreatic neuroendocrine tumor measuring less than 0.5 cm in diameter.


Refractory Neoplasm

A neoplasm that does not respond to treatment.


Posterior Subcapsular Cataract Grade 3

A stage of posterior subcapsular cataract characterized by 50% of the posterior capsule obscured by opacity. (Modified LOCS II)


Prostate cancer stage B

Tumor is clinically palpable but confined to the prostate.


Grade 2 Hypophysitis, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 1 Larynx Intra-Operative Injury, CTCAE


Jejunal Perforation, CTCAE

A disorder characterized by a rupture in the jejunal wall.


Metastatic Anal Canal Carcinoma

An anal canal carcinoma which has spread to another anatomic site.


Grade 3 Scalp Pain, CTCAE

Severe pain; limiting self care ADL


Grade 2 Nasal Congestion, CTCAE

Moderate symptoms; medical intervention indicated


Malignant Peritoneal and Retroperitoneal Neoplasm

A primary or metastatic malignant neoplasm that affects the peritoneum and/or retroperitoneum.


Hypernatremia

Higher than normal levels of sodium in the circulating blood.


Stage IIA Cervical Cancer AJCC v6

Tumor without parametrial invasion.


Stage IVB Fallopian Tube Cancer AJCC v8

Stage IVB includes: Any T, Any N, M1b. M1b: Fallopian tube cancer with liver or splenic parenchymal metastases; metastases to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); transmural involvement of intestine. (from AJCC 8th Ed.)


Stage IIIB Gestational Trophoblastic Tumor AJCC v7

Stage IIIB includes: Any T, M1a, Risk factors: high risk.  M1a: Lung metastasis.  (AJCC 7th ed.)


Recurrent Myxoid Glioneuronal Tumor

The reemergence of myxoid glioneuronal tumor after a period of remission.


Chronic total occlusion of coronary artery

Prolonged complete obstruction of the coronary artery. (ACC)


Grade 2 Muscular and Skeletal Hypoplasia, CTCAE


Anal Mucositis, CTCAE

A disorder characterized by ulceration or inflammation of the mucous membrane of the anus.


Artery NOS Intra-Operative Injury, CTCAE


Lymphatic Infection with Unknown Absolute Neutrophil Count, CTCAE


Fibrinolysis Shutdown

Acute impairment of breaking down fibrin clots leading to venous thromboembolism, stroke, and renal failure.


Metastatic Pancreatobiliary Carcinoma

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread from its original site of growth to another anatomic site.


Grade 1 Hypermagnesemia, CTCAE

>ULN-3.0 mg/dL; >ULN-1.23 mmol/L


Grade 3 Pulmonary Vein Intra-Operative Injury, CTCAE


Hearing Impaired, CTCAE

A disorder characterized by partial or complete loss of the ability to detect or understand sounds resulting from damage to ear structures.


Grade 1 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Lymphoma by AJCC v8 Stage

A term that refers to the staging of Hodgkin lymphoma and non-Hodgkin lymphoma according to the AJCC v8 classification guidelines.


Grade 3 Cervix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Incarcerated inguinal hernia

The trapping of bowel or omentum inside the inguinal canal that cannot be reduced, resulting in inflammation, pain, nausea, and possible bowel obstruction.


Lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Grade 3 Hyperhidrosis, CTCAE

Associated with electrolyte/hemodynamic imbalance


Grade 3 Adrenal Gland Intra-Operative Injury, CTCAE


Glycogen storage disease, type IX

Glycogen storage disease usually inherited in an X-linked recessive pattern.  It is characterized by a deficiency of hepatic phosphorylase kinase.


Grade 2 Tumor Hemorrhage, CTCAE

Moderate symptoms; intervention indicated


Pinhole meatus

A narrowing of the opening of the urethra at the external meatus.


Grade 4 Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Esophageal Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 5 Hypothermia, CTCAE

Death


Grade 4 Liver Intra-Operative Injury, CTCAE


Radiating Chest Pain in Neck

The location of the radiating chest pain is in the neck.


Grade 2 Gastrointestinal Stoma Necrosis, CTCAE

Superficial necrosis; intervention not indicated


Grade 2 Trachea Intra-Operative Injury, CTCAE


Grade 1 Salivary Gland or Saliva Changes, CTCAE


Grade 5 Ear and Labyrinth Disorders - Other, Specify, CTCAE

Death


Grade 3 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


AIDS-Related Carcinoma

Carcinoma occurring in HIV-positive patients.


Grade 4 Gallbladder Necrosis, CTCAE

Life-threatening consequences; urgent invasive intervention indicated


Monoclonal Hypergammaglobulinemia

A laboratory test result indicating abnormally high proliferation of the gamma globulins originating from one cell line.


Granuloma annulare aggravated

A chronic, inflammatory skin condition characterized by raised, ring shaped eruptions occurring singly or in groups; often on the tops of the hands, feet, elbows, and knees. It is commonly seen in children and young adults, and in women twice as much as men.


Bladder Cancer by AJCC v6 Stage

A term that refers to the staging of bladder cancer according to the American Joint Committee on Cancer, 6th edition.


Stage I Ampulla of Vater Cancer AJCC v7

Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0). T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades duodenal wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Metastatic Malignant Neoplasm to the Cervix

A malignant neoplasm that has spread to the cervix from another anatomic site.


Grade 5 Endocrine Disorders - Other, Specify, CTCAE

Death


Grade 3 Other Renal or Genitourinary, CTCAE


Grade 2 Cheilitis, CTCAE

Moderate symptoms; limiting instrumental ADL


Nephrotic Syndrome, CTCAE

A disorder characterized by symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction.


Anal Canal Intraepithelial Neoplasia

A precancerous neoplastic intraepithelial process involving the anal canal.  When it is clinically noticeable, it may appear as an eczematous or papillary lesion, plaques, or papules.  Morphologically, it is characterized by loss of epithelial stratification and nuclear polarity, cytologic atypia, and the presence of mitotic figures.  It may be classified as low or high grade.


Laryngeal nerve palsy

Damage to the laryngeal nerve that results in paralysis of the layrnx.


Grade 3 Sore Throat, CTCAE

Severe pain; limiting self care ADL; limiting ability to swallow


Grade 4 Thrombosis or Thrombus or Embolism, CTCAE


Acinar cell tumor

A benign or malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. It includes the acinar cell adenoma and acinar cell carcinoma.


Grade 1 Trachea Obstruction and Stenosis, CTCAE


Grade 4 Tumor Lysis Syndrome, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Budd-Chiari Syndrome, CTCAE

A disorder characterized by occlusion of the hepatic veins and typically presents with abdominal pain, ascites and hepatomegaly.


Helicobacter Pylori-Related Malignant Neoplasm


Grade 2 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Acidosis, CTCAE

pH <normal, but >=7.3


A pleomorphic xanthoastrocytoma that arises from the supratentorial region of the brain.


Kidney Anastomotic Leak, CTCAE

A finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures).


Spinal nerves paralysis permanent

Spinal nerve paralysis that is irreversible.


Organic failure to thrive

Failure to thrive (FTT), that occurs in less than five percent of FTT cases; it is caused by acute or chronic disorders that interfere with nutritional uptake, including cleft palate, malabsorption due to cystic fibrosis, and short gut syndrome.


Low grade cervical glandular intraepithelial neoplasia

Cervical glandular intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Malignant Pancreatic Vipoma

A pancreatic neuroendocrine tumor producing vasoactive intestinal peptide (VIP).  It is associated with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria.  It displays vascular invasion and metastasizes to other anatomic sites.  One third of cases are metastatic at the time of diagnosis.


Grade 4 Bullous Dermatitis, CTCAE

Blisters covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated


Grade 1 Cranial Nerve VIII Intra-Operative Injury, CTCAE


Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Other Dermatology or Skin, CTCAE


Grade 2 Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


Grade 5 Fever, CTCAE

Death


Gallbladder Pain, CTCAE 5.0

A disorder characterized by a sensation of marked discomfort in the gallbladder region.


Grade 1 Serum Glutamic Pyruvic Transaminase, CTCAE


Recurrent Primary Central Nervous System Neoplasm

The reemergence of a primary central nervous system neoplasm after a period of remission.


Grade 1 Hair Color Changes, CTCAE

Present


Angiosarcoma Associated with Lymphedema

An angiosarcoma that develops in association with long standing lymphedema.


T/NK-Cell Lymphoproliferative Disorder

A non-neoplastic or neoplastic proliferation of T-lymphocytes and/or NK-cells.


Central Nervous System Langerhans Cell Histiocytosis

Rare involvement of the central nervous system by Langerhans cell histiocytosis.


Injury to peritoneum without mention of open wound into cavity

Trauma to the peritoneum without indication of associated damage to the skin and other internal and external tissues.


Rectal Anastomotic Leak, CTCAE

A finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures).


Grade 3 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Anorectal Infection, CTCAE

A disorder characterized by an infectious process involving the anal area and the rectum.


Grade 5 Heart Infection with Unknown Absolute Neutrophil Count, CTCAE


Mucinous cystic neoplasm with low-grade intraepithelial neoplasia of gallbladder

A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of mild atypia.


Grade 4 Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Rectal Pain, CTCAE

Mild pain


Stage IIIA Testicular Cancer AJCC v8

Stage IIIA includes: (Any pT/TX, Any N, M1a, S0); (Any pT/TX, Any N, M1a, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Grade 4 Esophageal Perforation, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Tracheostomy Site Bleeding, CTCAE

Transfusion indicated; invasive intervention indicated


Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Sacral Fistula

A pathologic communication between the skin and the dural space that is located 5-25 mm from the anal verge.


Grade 4 Upper Gastrointestinal Hemorrhage NOS, CTCAE


Grade 3 Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


Extrahepatic Bile Duct Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Locally Advanced Primary Malignant Brain Neoplasm

A malignant neoplasm that arises from the brain that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Wheezing, CTCAE

Death


Retinoblastoma, differentiated

A retinoblastoma with well differentiated features. It often produces Flexner-Wintersteiner rosettes or Homer-Wright rosettes. In some cases the tumor cells form fleurettes.


Metastatic Gastric Carcinoma

A gastric carcinoma that has spread from its original site of growth to another anatomic site.


Grade 5 Pharyngeal Necrosis, CTCAE

Death


Mucositis and Stomatitis by Clinical Examination Classification, CTCAE


Mesothelioma malignant localised

A mesothelioma with the gross appearance of a circumscribed serosal lesion and the microscopic appearance of diffuse malignant mesothelioma, without evidence of diffuse spread.


Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

The reemergence of a blastic plasmacytoid dendritic cell neoplasm after a period of remission.


Grade 2 Liver Intra-Operative Injury, CTCAE


Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Abdominal Distension, CTCAE

Symptomatic; limiting instrumental ADL


Grade 5 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Trachea Infection with Unknown Absolute Neutrophil Count, CTCAE


Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 4 Neuralgia and Peripheral Nerve Pain, CTCAE


Grade 4 Adult Respiratory Distress Syndrome, CTCAE

Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Cervical Germ Cell Tumor

A rare germ cell tumor that arises from the cervix. Examples include mature cystic teratoma, yolk sac tumor, and choriocarcinoma.


Grade 1 Cushingoid, CTCAE

Mild symptoms; intervention not indicated


Hereditary factor I deficiency disease

An inherited blood coagulation disorder characterized by the partial or complete absence of fibrinogen in the blood, resulting in bleeding.


Accessory Nerve Disorder, CTCAE

A disorder characterized by dysfunction of the accessory nerve (eleventh cranial nerve).


Grade 2 Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Grade 2 Muscle Weakness Right-Sided, CTCAE

Symptomatic; evident on physical exam; limiting instrumental ADL


Stage IIC Appendix Carcinoma AJCC v8

Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Dyspnea, CTCAE

Death


Grade 2 Rectal Fissure, CTCAE

Symptomatic


Acoustic shock

Neurophysiological and psychological symptoms caused by sudden and unexpected loud noise.


Grade 3 Cervicitis Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Stage 0 Pancreatic Cancer AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Cutaneous Histiocytic and Dendritic Cell Neoplasm

A histiocytic and dendritic cell neoplasm that affects the skin.


Bloating, CTCAE

A disorder characterized by subject-reported feeling of uncomfortable fullness of the abdomen.


Grade 3 Vaginal Dryness, CTCAE

Severe vaginal dryness resulting in dyspareunia or severe discomfort


Grade 2 Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Anal Necrosis, CTCAE

A disorder characterized by a necrotic process occurring in the anal region.


Metastatic Malignant Skin Neoplasm

A malignant neoplasm of the skin that has spread to other anatomic sites.


Grade 3 Extrapyramidal Disorder, CTCAE

Severe involuntary movements or torticollis; limiting self care ADL


Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7

A rare acute myeloid leukemia that occurs in childhood and is characterized by deletion of chromosome 7.


Grade 4 Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Superior Vena Cava Vein Injury, CTCAE


Grade 4 Eye Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Intraoperative Breast Injury, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Muscular and Skeletal Hypoplasia, CTCAE


Stage IB1 Cervical Cancer FIGO 2018

Invasive cervical carcinoma with equal or more than 5 mm depth of stromal invasion, and less than 2 cm in greatest dimension. (FIGO 2018)


External Ear Pain

Painful sensation in the external ear region.


Fibrinogen Deficiency

A usually inherited blood coagulation disorder characterized by the partial or complete absence of fibrinogen in the blood, resulting in bleeding.


Grade 5 Small Bowel Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Ampulla of Vater Neuroendocrine Carcinoma

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma.  Patients usually present with advanced stage disease.


Disseminated adenocarcinoma

Adenocarcinoma that is spread throughout the body.


Recurrent Endometrial Squamous Cell Carcinoma

The reemergence of endometrial squamous cell carcinoma after a period of remission.


Unresectable Carcinoma

Carcinoma that is not amenable to surgical resection.


Refractory Metastatic Pancreatic Adenocarcinoma

Metastatic pancreatic adenocarcinoma that is resistant to treatment.


Intraoperative Respiratory Injury, CTCAE

A finding of damage to the respiratory system during a surgical procedure.


Grade 3 Other Sexual Reproductive Function, CTCAE


Grade 3 Fecal Incontinence, CTCAE

Severe symptoms; elective operative intervention indicated


POLE-Ultramutated Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by mutations in the exonuclease domain of the DNA polymerase epsilon (POLE) gene that result in an ultra-mutated tumor phenotype.


Grade 2 Gum Infection, CTCAE

Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 3 Major Visceral Vein Intra-Operative Injury, CTCAE


Hodgkin's disease nodular sclerosis stage I supradiaphragmatic


Grade 5 Disseminated Intravascular Coagulation, CTCAE

Death


Oligodendroblastoma

An obsolete term referring to neoplasms arising from oligodendrocytes.


Grade 2 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Periorbital Edema, CTCAE

Soft or non-pitting


Recurrent Abdominal Neuroendocrine Neoplasm

The reemergence of an abdominal neuroendocrine neoplasm after a period of remission.


Grade 3 Peripheral Nerve Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Advanced Sarcoma

A sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Adenovirus Infection

An adenovirus infection that has recurred after a period of remission.


Dysarthria, CTCAE

A disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech.


Grade 5 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Increased Colloid

Increase in the amount of colloid.


Grade 1 Eye NOS Intra-Operative Injury, CTCAE


Grade 2 Cystitis Noninfective, CTCAE

Moderate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL


Grade 4 Hypotension, CTCAE

Life-threatening consequences and urgent intervention indicated


Grade 3 Multi-Organ Failure, CTCAE

Shock with azotemia and acid-base disturbances; significant coagulation abnormalities


Grade 4 Febrile Neutropenia, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 4 Anal Sphincter Intra-Operative Injury, CTCAE


Vitreoretinal Disorder

A disorder affecting the vitreous fluid and retina.


Grade 2 Atrial Flutter, CTCAE

Non-urgent medical intervention indicated


Grade 2 Flu Like Symptoms, CTCAE

Moderate symptoms; limiting instrumental ADL


Uterine Non-Neoplastic Disorder

A non-neoplastic disorder that affects the uterine corpus or the cervix. Representative examples include endometritis, uterine adenomyosis, and cervicitis.


Grade 4 Bladder Perforation, CTCAE

Life-threatening consequences; organ failure; urgent operative intervention indicated


Grade 3 Intestinal Stoma Leak, CTCAE

Severe symptoms; invasive intervention indicated


Grade 5 Heart Failure, CTCAE

Death


Delusional disorder, erotomanic type

A subtype of delusional disorder characterized by the central delusional theme that another person (usually one of higher status) is in love with the individual.


Stage IV Esophagus Carcinoma

Stage IV includes: Any T, Any N, M1. IVA: Any T, Any N, M1a. IVB: Any T, Any N, M1b.  M1: Distant Metastasis. (AJCC 6th ed.) -2003


Grade 3 Middle Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


tubular adenoma of extrahepatic bile duct

An adenoma that arises from the extrahepatic bile ducts.  It is characterized by the presence of a tubular pattern.


Grade 3 Outer Ear NOS Intra-Operative Injury, CTCAE


Grade 3 Neonatal Diarrhea, AE

An adverse event in a newborn characterized by an increase of 7 stools or more per day over baseline; severe increase in ostomy output compared to baseline; signs of dehydration.


EBV-Related Malignant Neoplasm

A malignant neoplasm that develops in a patient infected with Epstein-Barr virus (EBV) and in which there is a well-documented association between the malignancy and EBV. Representative examples include EBV-related lymphomas and carcinomas.


Grade 2 Oculomotor Nerve Disorder, CTCAE


Peristomal Infection with Unknown Absolute Neutrophil Count, CTCAE


Uterine Ligament Papillary Cystadenoma

A cystadenoma that arises from the broad or other uterine ligaments. It is characterized by the presence of small papillary projections in the inner surface of the cysts. It may be sporadic or associated with von Hippel-Lindau disease.


Grade 3 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Uterine Corpus Cancer

Stage IV includes: IVA: (T4, Any N, M0); IVB: (Any T, Any N, M1). T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M0: No distant metastasis. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone.  It excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa). This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Sore Throat, CTCAE

A disorder characterized by marked discomfort in the throat


Irritability in Children Less Than 3 Years of Age, CTCAE


Grade 5 Esophageal Necrosis, CTCAE

Death


neoplasm of optic tract

A benign or malignant neoplasm that affects the optic tract.


Portal Vein Intra-Operative Injury, CTCAE


Grade 3 Middle Ear Inflammation, CTCAE

Mastoiditis; necrosis of canal soft tissue or bone


Prostate Acinar Adenocarcinoma, Sarcomatoid Variant

A rare morphologic variant of acinar adenocarcinoma of the prostate gland with unfavorable prognosis, composed of both malignant glandular and sarcomatous components.  The sarcomatous component contains a malignant spindle cell proliferation or specific mesenchymal elements including osteosarcoma, chondrosarcoma, and leiomyosarcoma.


Grade 2 Cranial Nerve XII Neuropathy, CTCAE


Malignant melanoma in giant pigmented nevus

A melanoma arising in a giant congenital melanocytic nevus. The risk of developing a melanoma in a giant congenital melanocytic nevus has been reported to be between 5% and 50%. The incidence of developing melanoma is higher before the age of 10 and in adult life.


Grade 3 Gastric Ulcer, CTCAE

Severely altered GI function; TPN indicated; elective invasive intervention indicated; limiting self care ADL


Grade 4 Mucosal Infection, CTCAE

Life-threatening consequences; urgent intervention indicated


Inner Restlessness

A feeling of unrest and/or an inability to feel calm or relaxed.


Early Disseminated Lyme Disease

An early stage of Lyme disease that may present days to weeks after a tick bite with relapsing signs of a red, concentrically-expanding rash (erythema migrans), facial palsy, meningismus, neuralgia, heart palpitations, and dizziness.


Grade 3 Neck Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pancreatic Delta Cell Adenoma

An endocrine neoplasm arising from the delta cells of the pancreas which produce somatostatin. It does not show evidence of vascular invasion or metastasis to other anatomic sites.


Transfusion hemosiderosis

Accumulation of iron in internal organs that results from repeated blood transfusions.


Grade 4 Stomach Infection with Unknown Absolute Neutrophil Count, CTCAE


Cervical Adenocarcinoma In Situ

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Microinvasive Malignant Neoplasm

A malignant neoplasm that has minimal stromal invasion.


Palsy of accessory nerve

Partial or complete paralysis of the spinal accessory nerve.


Advanced Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Lipase Increased, CTCAE

>2.0-5.0 x ULN with signs or symptoms; >5.0 x ULN and asymptomatic


Muscle Invasive Bladder Urothelial Carcinoma

A bladder urothelial carcinoma invading into the bladder muscularis propria.


Grade 3 Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Major Visceral Artery Intra-Operative Injury, CTCAE


Grade 4 Feeding Intolerance, AE

A feeding intolerance adverse event in a newborn characterized by life-threatening consequences.


Grade 3 Left Ventricular Diastolic Dysfunction, CTCAE


Chronic Kidney Disease, CTCAE

A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure.


Grade 1 Phantom Pain Associated with Missing Limb, CTCAE


Non-Neoplastic Retroperitoneal Disorder

A non-neoplastic disorder that affects the retroperitoneum.


Grade 1 Urinary Urgency, CTCAE

Present


Grade 1 Postoperative Hemorrhage, CTCAE

Mild symptoms; intervention not indicated


Adenocarcinoma, metastatic

An adenocarcinoma that has spread from its original site of growth to another anatomic site.


Grade 2 Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Uterine Fistula, CTCAE

Symptomatic, invasive intervention not indicated


Grade 3 Dry Skin, CTCAE

Covering >30% BSA and associated with pruritus; limiting self care ADL


Grade 2 Hypertension, CTCAE

Adult: Systolic BP 140-159 mm Hg or diastolic BP 90-99 mm Hg if previously WNL; change in baseline medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg; monotherapy indicated initiated; Pediatric and adolescent: Recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated; systolic and /or diastolic BP between the 95th percentile and 5 mmHg above the 99th percentile; Adolescent: Systolic between 130-139 or diastolic between 80-89 even if < 95th percentile


Grade 3 Atrial Flutter, CTCAE

Symptomatic, urgent intervention indicated; device (e.g., pacemaker); ablation


Grade 2 Peripheral Motor Neuropathy, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 5 Hypotension, CTCAE

Death


Grade 5 Gastric Hemorrhage, CTCAE

Death


Bronchopleural Fistula, CTCAE

A disorder characterized by an abnormal communication between a bronchus and the pleural cavity.


Grade 5 Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


Blood Bilirubin Increased, CTCAE

A finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice.


Metastatic Glioblastoma

Glioblastoma that has spread from its original site of growth to another anatomic site.


Cystic fibrosis pulmonary exacerbation

An acute episode of worsening pulmonary symptoms related to cystic fibrosis.


Grade 4 Laryngeal Mucositis, CTCAE

Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Immunodeficiency-Related Central Nervous System Lymphoma

A lymphoma that arises from the central nervous system in patients with acquired immunodeficiency conditions or rarely, hereditary immunodeficiency syndromes.


Grade 5 Duodenal Stenosis, CTCAE

Death


Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Major Visceral Vein Intra-Operative Injury, CTCAE


Ampulla of Vater Gangliocytic Paraganglioma

An extra-adrenal paraganglioma that arises from the ampulla of Vater and the periampullary region.  It consists of a mixture of neuroendocrine cells, Schwann-like cells, and ganglion cells.


Acute Megakaryoblastic Leukemia with CBFA2T3-GLIS2

A non-Down syndrome acute megakaryoblastic leukemia that occurs in childhood. It is associated with CBFA2T3-GLIS2 chimeric oncogene and has an unfavorable prognosis.


Desmoplastic trichilemmoma

A variant of tricholemmoma that is characterized by extensive sclerotic stroma formation.


Localized Malignant Neoplasm

A malignant neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Grade 3 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Non-Neoplastic Genitourinary System Disorder

A non-neoplastic disorder that affects the genitourinary system.


Grade 2 Neonatal Bradyarrhythmia, AE

A bradyarrhythmia adverse event in a newborn characterized by no change in age-appropriate behavior; requiring minor care changes (e.g. increased monitoring).


Stage IIA Esophageal Adenocarcinoma AJCC v7

Stage IIA includes: T2, N0, M0, G3.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis. G3: Poorly differentiated.  (AJCC 7th ed.)


Grade 4 Genitourinary Stoma Prolapse, CTCAE


Grade 3 Periorbital Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 4 Bile Duct Stenosis, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Hyponatremia with Hypoosmolality

Abnormally low serum sodium levels in the setting of electrolyte/fluid imbalance. This condition may be the result of excessive intake or retention of water and/or excretion of salt.


Iodine deficiency

A deficiency of iodine in the diet.


Airsickness

A sensation of discomfort associated with air travel that may include nausea, vomiting, dizziness, or sweating.


Stage II Appendix Carcinoma AJCC v8

Stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4a: Tumor invades through the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or serosa of the mesoappendix. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Wheezing, CTCAE

Moderate symptoms; medical intervention indicated; limiting instrumental ADL


Pneumonitis and Pulmonary Infiltrates, CTCAE


Grade 5 Seizure, CTCAE

Death


Grade 2 Ureter Intra-Operative Injury, CTCAE


Dyspareunia, CTCAE

A disorder characterized by painful or difficult coitus.


Grade 5 Lower Gastrointestinal Hemorrhage, CTCAE

Death


Grade 3 Cranial Nerve VIII Neuropathy, CTCAE


Grade 2 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Grade 3 Hypermagnesemia, CTCAE

>3.0-8.0 mg/dL; >1.23-3.30 mmol/L


Grade 2 Cervix Intra-Operative Injury, CTCAE


Grade 2 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Gastrointestinal Anastomotic Leak, CTCAE

Asymptomatic diagnostic finding; intervention not indicated


Grade 1 Edema of the Trunk and Genital Area, CTCAE


Grade 3 Cranial Nerve XII Intra-Operative Injury, CTCAE


Grade 5 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Adenosis

Any disease or disorder of a gland, characterized by abnormal development or enlargement of the gland.


Metastatic Primary Malignant Central Nervous System Neoplasm

A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to other sites.


Grade 5 Cranial Nerve III Neuropathy, CTCAE


Grade 3 Left Ventricular Systolic Dysfunction, CTCAE

Symptomatic due to drop in ejection fraction responsive to intervention


Grade 2 Pleural Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 4 Neonatal Sinus Bradycardia, AE

A sinus bradycardia adverse event in a newborn characterized by life-threatening consequences (e.g. shock); requiring urgent major care changes.


Adverse Event Associated with Coagulation


Mild esophageal dysplasia

A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal epithelium.  (WHO, 2000)


Prostate Acinar Adenocarcinoma, Microcystic Variant

A variant of acinar prostate adenocarcinoma characterized by the presence of microcystic foci in radical prostatectomy specimens.


Radiation-Recall Dermatitis

Acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmacologic agent.


Grade 3 Pancreatic Necrosis, CTCAE

Tube feeding or TPN indicated; invasive intervention indicated


Grade 5 Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Anal Hemorrhage, CTCAE

Transfusion indicated; invasive intervention indicated; hospitalization


AIDS-Related Pelvic Inflammatory Disease

Pelvic inflammatory disease that develops in a patient with HIV/AIDS.


Stage I Merkel Cell Carcinoma AJCC v7

Stage I includes: IA: (T1, pN0, M0) and IB: (T1, cN0, M0).  T1: Primary tumor equal or less than 2 cm in size.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Grade 3 Prostatic Pain, CTCAE

Severe pain; limiting self care ADL


Hidroacanthoma simplex

A rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct.


Grade 2 Breast Pain, CTCAE

Moderate pain; limiting instrumental ADL


Grade 2 Bladder Perforation, CTCAE

Invasive intervention not indicated


Lugano Classification Limited Stage Childhood Hodgkin Lymphoma AJCC v8

Limited stage childhood Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


HPV-related carcinoma

A carcinoma associated with the presence of human papillomavirus infection.


Grade 4 Sinusitis, CTCAE

Life-threatening consequences; urgent intervention indicated


Grade 5 Intraoperative Breast Injury, CTCAE

Death


Grade 2 Allergic Rhinitis Including Sneezing Nasal Stuffiness Postnasal Drip, CTCAE


Grade 2 Small Bowel Stricture or Stenosis NOS, CTCAE


Grade 2 Growth Hormone Abnormal, CTCAE

Symptomatic; medical intervention indicated; limiting instrumental ADL


Duodenal Infection, CTCAE

A disorder characterized by an infectious process involving the duodenum.


Hodgkin's disease lymphocyte depletion type stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Grade 5 Neonatal Gastrointestinal Bleeding, AE

A gastrointestinal bleeding adverse event in a newborn which results in death.


Grade 2 Small Intestinal Obstruction, CTCAE

Symptomatic; altered GI function; limiting instrumental ADL


Stage I Gestational Trophoblastic Tumor AJCC v7

Stage I includes: (T1, M0, Risk factors: unknown); IA (T1, M0, Risk factors: low risk); IB (T1, M0, Risk factors: high risk).  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIIA Cervical Cancer FIGO 2009

Cervical carcinoma involving lower one-third of the vagina. (FIGO 2009)


Grade 3 Rash Acneiform, CTCAE

Papules and/or pustules covering >30% BSA with moderate or severe symptoms; limiting self-care ADL; associated with local superinfection with oral antibiotics indicated


Stage III Ureter Cancer AJCC v7

Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into periureteric fat.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Peritoneal laceration

A cut or tear of the peritoneum.


Digestive System Hemangioma

A hemangioma arising from any part of the digestive system.


FancD2 Nuclear Foci Present

A laboratory test result indicating the presence of Fanconi anemia group D2 protein nuclear foci in cells, in response to DNA damage.


Xeroderma

A non-neoplastic disorder characterized by abnormally dry skin.  Causes include vitamin A deficiency, sunlight exposure, medications, metabolic disorders, autoimmune disorders, and hereditary genetic disorders.


Jejunal Fistula, CTCAE

A disorder characterized by an abnormal communication between the jejunum and another organ or anatomic site.


Malignant Esophageal Neoplasm by Topographic Region

Esophageal segments used primarily in pathology, and distinct from the anatomic segments used for clinical purposes.


Colorectal Cancer by Astler-Coller Stage


Grade 4 Gastrointestinal Disorders - Other, Specify, CTCAE


Grade 2 Cranial Nerve XI Neuropathy, CTCAE


Postneoadjuvant Therapy Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

Stage II includes: T3, N0, M0. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Acidophil carcinoma

A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic dyes.


Childhood Lymphocyte-Depleted Classic Hodgkin Lymphoma

Lymphocyte-depleted classic Hodgkin lymphoma occurring in childhood.


Grade 3 Dry Mouth, CTCAE

Inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min


Grade 3 Vomiting, CTCAE

Tube feeding, TPN, or hospitalization indicated


Grade 5 Esophageal Infection, CTCAE

Death


Grade 2 Supraventricular Tachycardia, CTCAE

Non-urgent medical intervention indicated


Grade 2 Thromboembolic Event, CTCAE

Medical intervention indicated


Transplant-Related Malignant Neoplasm

A malignant neoplasm that arises in a patient with a history of organ transplantation.


Grade 3 Splenic Infection, CTCAE

IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 1 Pulmonary Artery Intra-Operative Injury, CTCAE


Clinical Stage III Esophageal Adenocarcinoma AJCC v8

Stage III includes: (T2, N1, M0); (T3, N0-1, M0); (T4a, N0-1, M0). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Small Intestinal Perforation, CTCAE

Life-threatening consequences; urgent operative intervention indicated


Grade 3 Neonatal Spontaneous Intestinal Perforation, AE

An adverse event in a newborn characterized by presence of spontaneous intestinal perforation (SIP), non-urgent medical stabilization and surgical intervention indicated.


Acoustic Nerve Disorder NOS, CTCAE

A disorder characterized by dysfunction of the acoustic nerve (eighth cranial nerve).


Grade 2 Oral Cavity NOS Intra-Operative Injury, CTCAE


Febrile Neutropenia, CTCAE

A disorder characterized by an ANC <1000/mm3 and a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour


Childhood Hodgkin Lymphoma

Hodgkin lymphoma occurring in childhood.


Intracystic Papillary Breast Carcinoma

An intraductal breast carcinoma characterized by a papillary growth within a large cystic duct. There is no evidence of invasion of the breast parenchyma.


Metastatic Esophageal Carcinoma

A carcinoma that arises from the esophagus and has metastasized to another anatomic site.


Grade 5 Bronchial Fistula, CTCAE

Death


Grade 2 Uterine Perforation, CTCAE

Invasive intervention not indicated


Antepartum Obstetric Septic Embolism

Presence of bacterially-infected tissue in the maternal vascular system which originated from a distant site during the antepartum period.


Grade 2 Vaccination Site Lymphadenopathy, CTCAE

Localized ulceration; generalized lymph node enlargement


Urinary Tract Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Hair Texture Abnormal, CTCAE

A disorder characterized by a change in the way the hair feels.


Grade 4 Superior Vena Cava Intra-Operative Injury, CTCAE


Oral Hemorrhage, CTCAE

A disorder characterized by bleeding from the mouth.


Unresectable Large Cell Neuroendocrine Carcinoma

Large cell neuroendocrine carcinoma that is not amenable to surgical resection.


Esophageal Stenosis, CTCAE

A disorder characterized by a narrowing of the lumen of the esophagus.


Parotid Gland Intra-Operative Injury, CTCAE


Grade 4 Personality and Behavioral Change, CTCAE


Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Extrahepatic Bile Duct Lymphoma

A lymphoma that arises from the extrahepatic bile ducts, with the bulk of the disease located at this site.


Stage I Testicular Cancer AJCC v8

Stage I includes: pT1-T4, N0, M0, SX. pT1: Testicular cancer which is limited to testis (including rete testis invasion) without lymphovascular invasion. pT2: Testicular cancer which is limited to testis (including rete testis invasion) with lymphovascular invasion or invades hilar soft tissue or epididymis or penetrates visceral mesothelial layer covering the external surface of tunica albuginea with or without lymphovascular invasion. pT3: Testicular cancer in which the tumor invades spermatic cord with or without lymphovascular invasion. pT4: Testicular cancer in which the tumor invades scrotum with or without lymphovascular invasion. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Grade 3 Pneumothorax, CTCAE

Sclerosis and/or operative intervention indicated; hospitalization indicated


Keratin-Filled Cyst

A cyst that contains keratin.


Myopathy Secondary to Fatty Acid Oxidation Disorder

A myopathy that was caused by a primary disorder of fatty acid oxidation.


Grade 4 Fallopian Tube Stricture or Stenosis, CTCAE


NF1-Associated Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is associated with NF1 gene inactivation and a history of neurofibromatosis type 1.


Grade 1 Fat Atrophy, CTCAE

Covering <10% BSA and asymptomatic


Grade 4 Gallbladder Perforation, CTCAE

Life-threatening consequences; urgent intervention indicated


Lugano Classification Stage IIE Hodgkin Lymphoma AJCC v8

Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Dentophobia

A persistent, irrational fear of treatment, whether preventative or therapeutic, by a dentist, coupled with compulsive desire to avoid any such situation.


Grade 4 Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Teratoma

A teratoma that contains mature tissue elements and a limited amount of immature tissue elements.


Stage IIIC Vulvar Cancer AJCC v7

Stage IIIC includes: (T1/T2, N2c, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N2c: Vulvar cancer with lymph node metastasis with extracapsular spread.  M0: No distant metastasis.  (AJCC 7th ed.)


Perinatal disorder

A non-neoplastic or neoplastic disorder occurring during the period from about five months before birth to one month after birth.


Grade 5 Gastric Anastomotic Leak, CTCAE

Death


Grade 1 Atrial Flutter, CTCAE

Asymptomatic, intervention not indicated


Grade 5 Paroxysmal Atrial Tachycardia, CTCAE

Death


Grade 1 Alanine Aminotransferase Increased, CTCAE

>ULN-3.0 x ULN if baseline was normal; 1.5-3.0 x baseline if baseline was abnormal


Low Leukocyte Count

A lower than average level of leukocytes in a sample.


Vaginal Neuroendocrine Carcinoma

A rare neuroendocrine carcinoma that arises from the vagina. This category includes small cell and large cell neuroendocrine carcinoma.


Pathologic Stage IV Cutaneous Melanoma AJCC v8

Stage IV includes: Any T, Tis, Any N, M1. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. M1: Evidence of distant metastasis. (AJCC 8th ed.)


Grade 1 Skin Atrophy, CTCAE

Covering <10% BSA; associated with telangiectasias or changes in skin color


Grade 4 Pulmonary Edema, CTCAE

Life-threatening respiratory compromise; urgent intervention or intubation with ventilatory support indicated


Hypothermia, CTCAE

A disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below.


Hernia with Obstruction without Mention of Gangrene

The protrusion of an organ, or the fascia of an organ, through the wall of the cavity that normally contains it, which results in obstruction, without mention of necrosis of the herniated contents.


Grade 2 Dysmenorrhea, CTCAE

Moderate symptoms; limiting instrumental ADL


Grade 2 Body Odor, CTCAE

Pronounced odor; psychosocial impact; patient seeks medical intervention


Atypical adenomatous hyperplasia

Proliferation of glandular epithelial cells associated with the presence of cytologic atypia and architectural growth pattern changes.


Grade 3 Cranial Nerve IV Neuropathy, CTCAE


Rare Non-Neoplastic Disorder

A non-neoplastic disorder that is rare.


Stage IVC Appendix Carcinoma AJCC v8

Stage IVC includes: Any T, Any N, M1c, Any G. M1c: Metastasis to sites other than peritoneum. (AJCC 8th ed.)


Grade 1 Menorrhagia, CTCAE

Mild; iron supplements indicated


Grade 2 Bronchial Stricture, CTCAE

Symptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated (e.g., steroids, bronchodilators)


Recurrent Digestive System Neuroendocrine Neoplasm

The reemergence of a digestive system neuroendocrine neoplasm after a period of remission.


Cecal Hemorrhage, CTCAE

A disorder characterized by bleeding from the cecum.


Cutaneous Rosai-Dorfman Disease

Rosai-Dorfman disease affecting the skin. It manifests with multiple papules, nodules, or plaques.


Hypoxic ischemic encephalopathy neonatal

Injury to the central nervous system in the newborn period that occurs when there is insufficient delivery of oxygen to all or part of the brain.


Vaso-Occlusive Crisis

An exacerbation of sickle cell disease.


Skin Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Urinary Frequency, CTCAE

Present


Grade 2 Reproductive System and Breast Disorders - Other, Specify, CTCAE

Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Refractory T-Cell Prolymphocytic Leukemia

T-cell prolymphocytic leukemia that is resistant to treatment.


Grade 5 Vulval Infection, CTCAE

Death


Grade 1 Reproductive System and Breast Disorders - Other, Specify, CTCAE

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Locally Advanced Malignant Neoplasm

A malignant neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Recurrent Mature T-Cell and NK-Cell Neoplasm

The reemergence of mature T-cell and NK-cell neoplasm after a period of remission.


Status Migrainosus

An episode of migraine that persists for more than 72 hours.


Malabsorption, CTCAE

A disorder characterized by inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea.


Grade 2 Methemoglobinemia, CTCAE

>ULN


Malignant neoplasm aggravated

A malignant neoplasm that shows clinical and/or pathologic progression.


uterine cervical atrophy

A condition characterized by the absence of squamous maturation in the cervical epithelium. It is associated with decreased estrogen production.


Endometrial Endometrioid Adenocarcinoma with Papillae


Stage IA1 Cervical Cancer AJCC v8

Stage IA1 includes: T1a1, Any N, M0. T1a1: Invasive cervical carcinoma with measured stromal invasion of 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. M0: No distant metastasis. (AJCC 8th Ed.)


Severe Chronic Active EBV Infection

A severe form of chronic Epstein-Barr virus infection characterized by continued intermittent fever, lymphadenopathy, thrombocytopenia, lymphocytopenia, neutropenia, polyclonal gammopathy, and greatly elevated titers for antibodies to EBV-related antigens.


Metastatic Malignant Genitourinary System Neoplasm

A malignant neoplasm that arises from the genitourinary system and has metastasized to other anatomic sites.


Grade 5 Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Renal pelvis fistula

An abnormal communication between the renal pelvis and another anatomic site.


Grade 3 Wheezing, CTCAE

Severe respiratory symptoms limiting self care ADL; oxygen therapy or hospitalization indicated


Metastatic Gallbladder Carcinoma

A gallbladder carcinoma that has spread from the original site of growth to other anatomic sites.


Intraoperative Renal Injury, CTCAE

A finding of damage to the kidney during a surgical procedure.


Grade 3 Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Juvenile Myoclonic Epilepsy, Intractable, without Status Epilepticus

Intractable juvenile myoclonic epilepsy which is not associated with an acute, prolonged epileptic crisis.


Adenocarcinoma gastric recurrent

The reemergence of gastric adenocarcinoma after a period of remission.


Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


Peritoneal Dialysis Catheter-Associated Peritonitis

Infection of the peritoneum related to a peritoneal dialysis catheter.


Disseminated Listeriosis

A bacterial infection by Listeria monocytogenes in two or more non-contiguous sterile body compartments.


Superficial Epithelioma with Sebaceous Differentiation

A benign epithelial neoplasm occurring in the head, neck or back region. It is characterized by proliferation of basaloid cells in the upper dermis with broad attachments to the epidermis.


Grade 2 Female Genital Tract Fistula, CTCAE


Grade 3 Throat and Pharynx and Larynx Pain, CTCAE


Fallopian Tube Stricture or Stenosis, CTCAE


Refractory Anaplastic Ganglioglioma

Anaplastic ganglioglioma that is resistant to treatment.


Grade 2 Duodenal Infection, CTCAE

Moderate symptoms; medical intervention indicated (e.g., oral antibiotics)


Grade 3 Respiratory Tract Hemorrhage NOS, CTCAE


Grade 4 Ligament Intra-Operative Injury, CTCAE


Grade 2 Lens Intra-Operative Injury, CTCAE


Vaginal Warty Carcinoma

A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, hyperkeratosis, and koilocytosis.


Infection of peritoneal dialysis catheter

A local or systemic infection associated with the use of a peritoneal dialysis catheter.


Grade 2 Spermatic Cord Anastomotic Leak, CTCAE

Symptomatic; medical intervention indicated


Stage I Bone Cancer AJCC v8

Stage I includes: IA: (T1, N0, M0, G1 or GX); IB: (T2, N0, M0, G1 or GX); (T3, N0, M0, G1 or GX). T1: Tumor measuring 8 cm or less in greatest dimension. T2: Tumor measuring more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


Grade 2 Stoma Site Infection, CTCAE

Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Human Papillomavirus-Independent Cervical Squamous Cell Carcinoma

A cervical squamous cell carcinoma not associated with human papillomavirus infection.


Grade 4 Corneal Ulcer, CTCAE

Perforation in the affected eye


p53-Mutant Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by the presence of p53 gene mutations.


Tracheal web

A rare congenital or acquired abnormality characterized by the presence of a web-like thin layer of tissue that narrows the lumen of the trachea. It may result in wheezing, dyspnea, and respiratory failure.


Grade 1 Anxiety, CTCAE

Mild symptoms; intervention not indicated


Grade 1 Folliculitis, CTCAE

Covering <10% of the body surface area; no intervention indicated


Gastric hyperplastic polyp

A non-neoplastic polyp that arises from the stomach and is characterized by the presence of dilated gastric foveoli, edematous changes, and inflammation.


Grade 1 Carotid Artery Intra-Operative Injury, CTCAE


Extrapulmonary Small Cell Carcinoma

A small cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


Refractory Male Reproductive System Carcinoma

Male reproductive system carcinoma that is resistant to treatment.


Proliferative Inflammatory Atrophy

A lesion in the prostate gland characterized by glandular atrophy, chronic inflammation, and epithelial hyperplasia. It has been suggested that it is a precancerous lesion and it may lead to the development of prostatic intraepithelial neoplasia and prostatic carcinoma.


External hemorrhoids (disorder)

A hemorrhoid which originates below the dentate line.