Amrubicin

Amrubicin is a third-generation anthracycline and potent topoisomerase II inhibitor, for used in the treatment of small-cell lung cancer (SCLC) in Japan.

A synthetic anthracycline antibiotic with molecular formula C25H25NO9. A specific inhibitor of topoisomerase II, it is used (particularly as the hydrochloride salt) in the treatment of cancer, especially lung cancer, where it is a prodrug for the active metabolite, ambrucinol.


Diverticular perforation

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Drug level fluctuating

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epidural abscess

Circumscribed collections of suppurative material occurring in the spinal or intracranial epidural space. The majority of epidural abscesses occur in the spinal canal and are associated with osteomyelitis of a vertebral body; analgesia, epidural; and other conditions. Clinical manifestations include local and radicular pain, weakness, sensory loss, urinary incontinence, and fecal incontinence. Cranial epidural abscesses are usually associated with osteomyelitis of a cranial bone, sinusitis, or otitis media. (From Adams et al., Principles of Neurology, 6th ed, p710 and pp1240-1; J Neurol Neurosurg Psychiatry 1998 Aug;65(2):209-12)


Extranodal marginal zone B-cell lymphoma (MALT type)


Fat Necrosis

Destruction of adipose tissue caused by the activity of lipase on damaged fat cells.


Recurrent tumor

The reemergence of a neoplasm after a period of remission.


Abnormality of the nose

An abnormality of the nose.


Obstruction

Blockage of the normal flow of the contents of an anatomical passageway.


obstructive lung disease

Any disorder marked by obstruction of conducting airways of the lung. airway obstruction may be acute, chronic, intermittent, or persistent.


Parainfluenza Virus Infections

A viral infection caused by a parainfluenza virus, typically resulting in infections of the lower respiratory tract.


Parasomnia

An undesirable physical event or experience that occurs during the process of falling asleep, while asleep, or when waking up from sleep.


Pulmonary Function Test Decreased

A decrease in any of the parameters used to measure the mechanical function of the lungs and upper airway.


Pulmonary toxicity

Toxicity that impairs or damages the lung(s). This condition is often caused by the administration of a pharmaceutical agent that causes damage to the lungs.


Food intolerance

A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction.


Malignant neoplasm of stomach stage IV

Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 7th ed.)


gastric neoplasm

A benign or malignant neoplasm involving the stomach.


Gastrointestinal disorder congenital

An abnormality of the digestive system that is present at birth or detected in the neonatal period.


glomerulosclerosis

A hardening of the kidney glomerulus caused by scarring of the blood vessels.


Liver Lesion

A localized pathological or traumatic structural change, damage, deformity, or discontinuity of the liver.


hepatobiliary disorder

A non-neoplastic or neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples of non-neoplastic disorders include hepatitis, cirrhosis, cholangitis, and cholecystitis. Representative examples of neoplastic disorders include hepatocellular adenoma, hepatocellular carcinoma, and cholangiocarcinoma.


lung neoplasm

A benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma.


Abnormal lymphocyte morphology

An abnormality of lymphocytes.


skin pigmentation disorder

A pigmentation disease that involves the zone of skin.


Renal Mass

An abnormal growth in the kidney.


viral respiratory tract infection

A respiratory tract infection caused by a virus. Viruses represent the most common causes of upper and lower respiratory tract infections and include rhinoviruses, influenza viruses, parainfluenza viruses, and respiratory syncytial virus.


Vascular Access Complication

Complications related to damage at the vascular access site. Examples include bleeding, formation of hematoma, aneurysm, pseudoaneurysm, or arteriovenous fistula, development of infection, and catheter thrombosis.


Venous occlusion

Blockage of venous return (flow of blood from the periphery back towards the right atrium) in a vein.


capillary disorder

A disease involving a capillary.


nasal disorder

A disease involving the nose.


Abnormal Urine Test Result

A laboratory test result indicating a finding outside the parameters of normal urine measurements.


paranasal sinus disorder

A disease involving the paranasal sinus.


Soft Tissue Infection

A bacterial infectious process affecting the soft tissues. A severe form caused by anaerobic or aerobic bacteria is associated with soft tissues necrosis and affects the subcutaneous adipose tissue, muscles, fascia, and the skin.


spinal cord neoplasm

A neoplasm (disease) that involves the spinal cord.


Small intestinal stenosis

The narrowing or partial blockage of a portion of the small intestine.


Lipohypertrophy

Hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin.


Leukemia recurrent

The reemergence of leukemia after a period of remission.


Non-Cardiac Chest Pain

Pain in the chest unrelated to a heart disorder.


Tooth Fractures

Broken tooth affecting any portion of tooth: root fracture, crown-root, broken tooth (crown fracture), chipped tooth. A crown fracture can involve the pulp. Tooth fracture sequelae range in severity from cosmetic defects to tooth death. Involvement of the pulp is a more important indicator of severity of tooth fracture than is the amount of the tooth affected.


Scleroderma renal crisis

The onset of acute renal failure, normally coupled with marked hypertension in a patient with scleroderma.


Enterovesical Fistula

An abnormal communication between the urinary bladder and the intestine.


hypophysitis

Inflammation of the pituitary gland.


hyperamylasemia

Abnormally high level of amylase in the blood.


melanoma, cutaneous malignant, susceptibility to, 2

Clinically atypical nevi (usually exceeding 5 mm in diameter and having variable pigmentation and ill defined borders) with an increased risk for development of non-familial cutaneous malignant melanoma. Biopsies show melanocytic dysplasia. Nevi are clinically and histologically identical to the precursor lesions for melanoma in the B-K mole syndrome. (Stedman, 25th ed)


facial spasm

Sudden, repetitive, nonrhythmic motor movements (spasms), involving the eyes and muscles of the face.


effusion

A collection of fluid in a body cavity, which may be the result of a non-neoplastic disorder (e.g. heart failure) or a tumor (e.g. carcinoma of the lung).


Non-Infectious Cystitis

An inflammation of the bladder which is not caused by an infection of the urinary tract. Representative examples include interstitial cystitis and radiation-induced cystitis.


postural orthostatic tachycardia syndrome

A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart.


Macular scar

Scar tissue in the macula.


Fungal endophthalmitis

Inflammation of the lining of the ocular cavities, which results from a fungal infection.


Crouzon syndrome-acanthosis nigricans syndrome

Crouzon syndrome with acanthosis nigricans (CAN) is a very rare, clinically heterogeneous form of faciocraniostenosis with Crouzon-like features and premature synostosis of cranial sutures (Crouzon disease), associated with acanthosis nigricans (AN).


Metamorphopsia

A visual anomaly in which images appear distorted. A grid of straight lines appears wavy and parts of the grid may appear blank.


International normalized ratio fluctuation


Polypoidal choroidal vasculopathy

The presence of aneurysmal polypoidal lesions in the choroidal vasculature. The aneurysmal dilatations, also known as polyps, may be found at subfoveal, juxtafoveal, extrafoveal, peripapillary or even peripheral regions. These polypoidal dilatations may be visible as reddish-orange subretinal nodules during ophthalmoscopic examination. The polypoidal lesions are best detected on indocyanine green angiography (ICGA) and might be associated with a branching vascular network (BVN) of neovascularization.


Hypophagia

Reduced ingestion of food.


Gene mutation identification test positive


spondylolisthesis

A condition in which there is forward displacement of a vertebral bone over the on below it.


Hyperglycemic hyperosmolar nonketotic syndrome


metastatic squamous cell carcinoma

A squamous cell carcinoma which has spread from its original site of growth to another anatomic site.


Perforation of bladder

A rupture in the bladder wall due to traumatic or pathologic processes.


Atlantoaxial instability

Abnormally increased movement at the junction between the first cervical (atlas) and the second cervical (axis) vertebrae as a result of either a bony or ligamentous anomaly.


Upper motor neuron dysfunction

A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs.


Cerebral artery stenosis

Narrowing or constriction of the inner surface (lumen) of a cerebral artery.


Pregnancy after post coital contraception


Rh Incompatibility

A complication during pregnancy; it occurs when the mother is Rh-negative and the infant is Rh-positive. This complication generally does not affect first-born Rh-positive babies. Rh-positive newborn babies from subsequent pregnancies develop complications of Rh incompatibility which include hemolysis, jaundice, enlarged liver and spleen, petechiae, hypotonia, neurologic damage, and heart problems.


Iris hypopigmentation

An abnormal reduction in the amount of pigmentation of the iris.


ichthyosis prematurity syndrome

Ichthyosis prematurity syndrome is a rare, syndromic congenital ichthyosis characterized by premature birth (at gestational weeks 30-32, in general) in addition to thick, caseous and desquamating epidermis, neonatal respiratory asphyxia, and persistent eosinophilia. After the perinatal period, a spontaneous improvement in the health of affected patients is observed and skin features (vernix caseosa-like scale) evolve into a mild presentation of flat follicular hyperkeratosis with atopy.


familial atrioventricular septal defect

A spectrum of septal defects involving the atrial septum; ventricular septum; and the atrioventricular valves (tricuspid valve; bicuspid valve). These defects are due to incomplete growth and fusion of the endocardial cushions which are important in the formation of two atrioventricular canals, site of future atrioventricular valves.


autism

Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior.


Arachnodactyly

Abnormally long and slender fingers ("spider fingers").


Lower respiratory tract infection bacterial


Sudden unexpected death in epilepsy

Sudden unexpected death in epilepsy (SUDEP) is a sudden, unexpected, witnessed or unwitnessed, non-traumatic and non-drowning death, occurring in benign circumstances, in an individual with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus, in which postmortem examination has not revealed a cause of death.


Sleep disorder due to a general medical condition


Enteroviral encephalitis

Inflamation of the brain related to infection by an enterovirus.


Non-high-density lipoprotein cholesterol increased


Lichenoid actinic keratosis

A benign intraepidermal squamoproliferative neoplasm characterized by irregular acanthosis, hyperkeratosis, parakeratosis, and prominent chronic inflammation.


heart septal defect

A congenital disorder characterized by the presence of an abnormal communication between the atria or the ventricles of the heart due to defects in the cardiac septum.


volvulus of midgut

A congenital abnormality in which the intestine is abnormally rotated (twisted). It may result in intestinal obstruction.


multiple system atrophy

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure (cardiovascular and/or urinary), parkinsonism, cerebellar impairment and corticospinal signs with a median survival of 6-9 years.


neurodevelopmental disorder

A behavioral and cognitive disorder with onset during the developmental period that involves impaired or aberrant development of intellectual, motor, or social functions.


Multiple lentigines

Presence of an unusually high number of lentigines (singular: lentigo), which are flat, tan to brown oval spots.


Gastrointestinal inflammation

Inflammation of the alimentary part of the gastrointestinal system.


Labeled drug-drug interaction medication error


Labeled drug-disease interaction medication error


extrapulmonary tuberculosis

A tuberculosis that occurs at body sites other than the lung.


Stoma Site Infection

An infectious process affecting a surgically created opening in the surface of the body.


Positive EBV Test

A laboratory test result indicating the presence of the Epstein-Barr virus in a biological sample.


Breakthrough pain

A episode of severe pain that breaks through (i.e., temporarily exacerbates) a period of persistent pain.


desmoplastic small round cell tumor

Desmoplastic small round cell tumor (DSRCT) is an aggressive soft tissue cancer that typically arises in serous lined surfaces of the abdominal or pelvic peritoneum, and spreads to the omentum, lymph nodes and hematogenously disseminates especially to the liver. Extraserous primary location has been reported in exceptional cases.


Erosion of oral mucosa

Loss of the superficial layer of the oral mucosa usually resulting in a shallow or crusted lesion.


periodic limb movement disorder

Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387)


Placental infarction

Interruption of the blood supply to a portion of the placenta, resulting in ischemic necrosis.


Clodronic Acid

A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.


Feculent vomiting

Vomiting of material that is of fecal origin.


Device related infection

An infectious disorder caused by the use of a medical device.


Dactylitis

Inflammation of the fingers or toes. This may be accompanied by pain and discoloration.


Infusion Site Extravasation

Leakage of a pharmacologic or a biological substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation, and pain at the infusion site.


Abnormal breath sound

An anomalous (adventitious) sound produced by the breathing process.


Tachyphrenia

The sensation that thoughts are moving too quickly.


Head titubation

A head tremor of moderate speed (3 to 4 Hz) in the anterior-posterior direction.


plasmablastic lymphoma

An aggressive diffuse large B-cell lymphoma frequently arising in the setting of HIV infection and characterized by the presence of large neoplastic cells resembling B-immunoblasts which have the immunophenotypic profile of plasma cells. Sites of involvement include the oral cavity, sinonasal cavity, skin, soft tissues, gastrointestinal tract, and bone.


immune reconstitution inflammatory syndrome

An inflammatory condition that arises after initiating antiretroviral therapy (ART) therapy in HIV-infected patients that results from restored immunity to specific infectious or non-infectious antigens.


latent tuberculosis infection

Mycobacterium tuberculosis infection that does not induce infectious expression of the disease in the affected person, although it can cause continuous immune response generated towards TB antigens; person having LTBI are asymptomatic and acting as a reservoir of active tuberculosis tuberculosis cases and Mycobacterium tuberculosis and run a 5-10% risk of reactivating tuberculosis throughout their lives.


Lower respiratory tract infection fungal


Mycotic pericarditis

Pericarditis that is caused by an infection with a fungal agent.


Dental Fistula

Localized collection of pus in the tissues that enclose the root of a tooth and is associated with the presence of a sinus tract.


Spontaneous hematomas

Spontaneous development of hematomas (hematoma) or bruises without significant trauma.


Urinary Tract Fistula

An abnormal communication between any part of the urinary system and another organ or cavity.


Lemierre syndrome

Lemierre syndrome is a rare, potentially lethal, oropharyngeal infectious disease occurring in immunocompetent adolescents and young adults that is mainly due to Fusobacterium necrophorum and that is characterized by septic thrombophlebitis of the internal jugular vein that leads to septic, usually pulmonary, embolism, associated with ENT (ear, nose, and throat) infection that manifests with fever, neck pain, and tonsillopharyngitis.


Bone marrow hypocellularity

A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat.


Nephritic syndrome

A syndrome characterized by hematuria with dysmorphic red blood cells, red blood cell casts, and proteinuria; systemic manifestations may be present, including hypertension, edema, oliguria.


Oral Cavity Fistula

An abnormal communication between the oral cavity and the adjacent tissues.


Bronchial hemorrhage

Bronchial hemorrhage is a focal bleeding located in the bronchial system. It can be diagnosed by tracheobronchoscopy.


Ovarian Hemorrhage

Bleeding originating from the ovary.


Mucosal Infection

An acute or chronic infectious process affecting a mucosal surface.


Musculoskeletal Deformity

Congenital or acquired deformity of the musculoskeletal system.


Tracheal fistula

An abnormal communication between the trachea and another organ or anatomic site.


Vaginal fistula

The presence of a fistula of the vagina.


Esophageal Fistula

An abnormal communication between the esophagus and another organ or anatomic site.


Digestive System Anastomotic Leakage

Leakage due to breakdown of a gastrointestinal anastomosis.


Cardiovascular insufficiency

Circulatory insufficiency due to a decrease in the force of the cardiac contractions and/or the tone of the vascular walls.


Left ventricle outflow tract obstruction


Truncal obesity

Obesity located preferentially in the trunk of the body as opposed to the extremities.


Fine motor delay

Delayed acquisition of age appropriate motor milestones that produce small and precise movements.


Stress urinary incontinence

Involuntary urine leakage synchronous with exertion, or actions such as sneezing, or coughing.


central nervous system leukemia

Leukemia infiltrating the central nervous system structures.


Cytopenia

A laboratory test result indicating an abnormally low quantity of circulating blood cells.


Acute graft versus host disease in liver


Acute graft versus host disease in intestine


Tako-tsubo cardiomyopathy

Takotsubo cardiomyopathy (TC) is a recently described acute cardiac syndrome that mimics acute myocardial infarction and is characterized by ischemic chest symptoms, an elevated ST segment on electrocardiogram, and elevated levels of cardiac disease markers.


keratosis pilaris

A form of dry skin characterized by hair follicles plugged by scale.


Hypersexuality

Pathological persistent sexual disinhibiting behavior, directed towards oneself or others.


Toxic anterior segment syndrome

An acute postoperative inflammatory reaction in which a noninfectious substance enters the anterior segment of the eye and induces toxic damage to the intraocular tissues.


Tendon pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to a tendon.


latent autoimmune diabetes in adults

A type 1 diabetes mellitus that is characterized by a less intensive autoimmune process, highly variable β-cell destruction, different degrees of insulin resistance and heterogeneous titre and pattern of islet autoantibody, sharing features with both type 1 and type 2 diabetes mellitus.


human herpesvirus 8 infection

An infectious process caused by the human herpesvirus 8. This infection is associated with Kaposi sarcoma.


hematopoietic and lymphoid system neoplasm

Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). --2003


Recurrent Medulloblastoma

The reemergence of medulloblastoma after a period of remission.


Neuroblastoma recurrent

The reemergence of neuroblastoma after a period of remission.


Melanoma recurrent

The reemergence of a melanoma after a period of remission.


Recurrent ovarian cancer

The reemergence of ovarian carcinoma after a period of remission.


acute interstitial pneumonia

Acute interstitial pneumonia (AIP), also referred to as Hamman-Rich syndrome, is a rapidly progressive and histologically distinct form of idiopathic interstitial pneumonia.


Human herpesvirus 6 infection reactivation


Injury of liver

Damage to liver structure or function due to trauma or toxicity.


alveolar periostitis

A condition sometimes occurring after tooth extraction, particularly after traumatic extraction, resulting in a dry appearance of the exposed bone in the socket, due to disintegration or loss of the blood clot. It is basically a focal osteomyelitis without suppuration and is accompanied by severe pain (alveolalgia) and foul odor. (Dorland, 28th ed)


Fistula Discharge

The leakage of a substance from a fistula.


Regurgitation

Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward flowing of blood into the heart, or between the chambers of the heart when a valve is incompetent.


Sleep-related eating disorder

Eating during sleep.


osteoradionecrosis

Necrosis of bone following radiation injury.


disorder of pharynx

A non-neoplastic or neoplastic disorder that affects the pharynx. Representative examples include pharyngitis and carcinoma.


Radiation necrosis

Tissue necrosis due to radiation exposure.


cloacal exstrophy

A major birth defect representing the severe end of the spectrum of the exstrophy-epispadias complex (EEC) characterized by omphalocele, exstrophy, imperforate anus and spinal defects (also referred to as the OEIS complex), often associated with other malformations.


nephrogenic systemic fibrosis

Nephrogenic systemic fibrosis (NSF) is a rare systemic fibrosing condition observed in renally impaired patients and characterized by a hardening and thickening of the skin with fibrotic plaques or papules, pruritus, joint pain and stiffness, muscle weakness, limitation of range of motion, and yellowed eyes. It is generally associated with administration of gadolinium-based magnetic resonance imaging contrast agents (GBCA) in patients with kidney disease.


Rotavirus infection

Infection with any of the rotaviruses. Specific infections include human infantile diarrhea, neonatal calf diarrhea, and epidemic diarrhea of infant mice.


Organizing pneumonia

Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias, but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal and sometimes bronchocentric. Other manifestations of organizing pneumonia include groundglass opacity, tree-in-bud pattern, and nodular opacities.


chromosomal disorder

Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)


Adverse reactions

Any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out.


Impaired vibratory sensation

A decrease in the ability to perceive vibration. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to bony prominences such as the malleoli at the ankles or the metacarpal-phalangeal joints. There is a slow decay of vibration from the tuning fork. The degree of vibratory sense loss can be crudely estimated by counting the number of seconds that the examiner can perceive the vibration longer than the patient.


mouth disorder

A disease involving the mouth.


Heart valve regurgitation

Dysfunction of one of the cardiac valves characterized by incomplete valve closure.


Toxic polyneuropathy

Polyneuropathy that is caused by exposure to toxins.


Skin plaque

A plaque is a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter.


Hyperlipasaemia

A laboratory test result which indicates increased levels of lipase in a biologic specimen.


focal segmental glomerulosclerosis

A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.


Upper airway obstruction

Increased resistance to the passage of air in the upper airway.


Oromandibular dystonia

A kind of focal dystonia characterized by forceful contractions of the face, jaw, and/or tongue causing difficulty in opening and closing the mouth and often affecting chewing and speech.


myelodysplastic syndrome with multilineage dysplasia

Refractory cytopenias with multilineage dysplasia (RCMD) is a frequent subtype of myelodysplastic syndrome (MDS) characterized by 1 or more cytopenias in the peripheral blood and dysplasia in 2 or more myeloid lineages.


Eastern Cooperative Oncology Group performance status worsened


Malar rash

An erythematous (red), flat facial rash that affects the skin in the malar area (over the cheekbones) and extends over the bridge of the nose.


intellectual disability

A broad category of disorders characterized by an impairment to the intelligence an individual possesses. These impairments can result from trauma, birth, or disease and are not restricted to any particular age group.


cerebral amyloid angiopathy

Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.


burning mouth syndrome

A condition characterized by a burning or tingling sensation on the lips, tongue, or entire mouth.


Epithelial Microcyst

Very small, round vesicles containing fluid and cellular debris observed on the surface of the cornea under slit-lamp examination in some types of corneal dystrophy and in wearers of extended-wear lenses.


cardio-renal syndrome

A disorder of the heart and kidneys in which dysfunction of one of the organs induces dysfunction of the other organ.


Transaminitis

Abnormally high levels of alanine transaminase (ALT) and/or aspartate transaminase (AST) in the blood.


Epstein-Barr virus-associated malignant lymphoproliferative disorder

A lymphoproliferative disorder associated with Epstein-Barr virus. This category includes, but is not limited to, Burkitt lymphoma, classic Hodgkin lymphoma, and lymphomas arising in immunocompromised individuals.


Creatinine clearance-glomerular filtration outside reference range


Decreased fetal movement

An abnormal reduction in quantity or strength of fetal movements.


myelodysplastic syndrome associated with isolated del(5q)

A myelodysplastic syndrome characterized by a deletion between bands q31 and 33 on chromosome 5. The number of blasts in the bone marrow and blood is <5%. The bone marrow is usually hypercellular or normocellular with increased number of often hypolobated megakaryocytes. The peripheral blood shows macrocytic anemia. This syndrome occurs predominantly but not exclusively in middle age to older women. The prognosis is good and transformation to acute leukemia is rare. (WHO, 2001)


C-reactive protein outside reference range


Respiratory syncytial virus test positive


Pulmonary hypertensive crisis

Pulmonary hypertensive crisis involves sudden and potentially lethal increases in PAP and PVR that cause acute rise in right atrial and right ventricular end-diastolic pressure accompanied by low cardiac output.


Facial asymmetry

An abnormal difference between the left and right sides of the face.


Pulmonary cyst

A round circumscribed space within a lung that is surrounded by an epithelial or fibrous wall of variable thickness. A cyst usually has a thin and regular wall (less than 2 mm) and contains air, although some may contain fluid.


Overlap syndrome

An autoimmune, connective tissue disorder in which the patient exhibits features from two or more diseases. These typically include systemic sclerosis, dermatomyositis, polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and Sjogren syndrome; in pediatrics the respective pediatric entities are encountered.


Anti-cyclic citrullinated peptide antibody positive


Terminal insomnia

A type of insomnia characterized by waking up too early in the morning is known as early morning awakening. The termination of sleep must occur at least 30 minutes before the desired time.


autoimmune pancreatitis

Autoimmune pancreatitis (AIP) is a rare pancreatic disease characterized by chronic non-alcoholic pancreatitis that presents with abdominal pain, steatorrhea, obstructive jaundice and responds well to steroid therapy and is seen in two subforms: type 1 AIP which affects elderly males, involves other organs and has increased immunoglobin G4 (IgG4) levels and type 2 AIP which affects both sexes equally but presents at a younger age and has no other organ involvement or increased IgG4 levels.


tubulointerstitial nephritis and uveitis syndrome

An autoimmune disorder comprising tubulointerstitial nephritis and uveitis.


Delayed gross motor development

A type of motor delay characterized by a delay in acquiring the ability to control the large muscles of the body for walking, running, sitting, and crawling.


acute kidney failure

Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria.


Iotalamic acid

A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.


Bambuterol

selective inhibitor of butyrylcholinesterase & acetylcholinesterase

A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.


Subretinal fluid

Edema/fluid accumulating between the retinal pigment epithelium and Bruch's membrane.


Lung Injury

Damage to the lung from traumatic or pathologic processes.


idiopathic camptocormia

Idiopathic camptocormia is a postural disease characterized by an anterior flexion of the torso (during walking or standing) that resolves in the supine position and that is caused by weakness of the lumbar paraspinal muscles (spinal extensors), due to massive fatty infiltrations of posterior spinal muscles, without an identifiable etiology.


Disseminated mycobacterium avium complex infection


Reticulin Fibrosis of the Bone Marrow

Increased reticular fiber deposition within bone marrow.


Spinal Injuries

Damage to the spine that results in impaired function.


swine influenza

An acute viral respiratory infection caused by a strain of influenza virus which is endemic in swine (pigs). Rarely reported in humans prior to 2009, the disease is caused by a mutated strain of swine influenza A (H1N1) virus. It is highly contagious and spreads mainly through coughing and sneezing. Signs and symptoms include fever, chills, coughing, sore throat headache, muscle ache, and generalized weakness. Antiviral medications are most effective in the first two days of the illness.


Renal hemangioma

A rare hemangioma arising from the kidney.


Foreign Bodies

Extraneous material within the body.


Executive dysfunction

Cognitive, emotional, and behavioral difficulties that often occur in conjunction with frontal lobe disorders, including traumatic injury and dementia. It is also a feature of attention deficit disorder and other non-trauma-induced conditions.


Infective exacerbation of bronchiectasis


Motor delay

A type of Developmental delay characterized by a delay in acquiring motor skills.


refractory malignant neoplasm

A malignant neoplasm that does not respond to treatment.


Mycobacterium tuberculosis complex test positive


Chemical peritonitis

A non-infectious inflammation of the peritoneum.


Increased urine urobilinogen

An elevated concentration of urobilinogen in the urine.


Hypoxic-Ischemic Encephalopathy

Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures.


hypertension, pregnancy-induced

A hypertensive disorder that develops during pregnancy.


Distributive shock

A hyperdynamic process resulting from excessive vasodilatation. Impaired blood flow causes inadequate tissue perfusion, which can lead to end-organ damage


Infective pulmonary exacerbation of cystic fibrosis


Heparin-induced thrombocytopenia test positive


Intentional medical device removal by patient


Pholcodine

A morphinane alkaloid that is a derivative of morphine with a 2-morpholinoethyl group at the 3-position.


Xylazine

An adrenergic alpha-2 agonist used as sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE

A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.


Hypocitraturia

A lower than normal concentration of citrate(3-) in the urine.


Stage I Ovarian Cancer AJCC v6 and v7

Stage I includes: T1, N0, M0. T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Ovarian epithelial cancer stage II

Stage II includes: T2, N0, M0.  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Ovarian cancer stage III

Stage III includes: T3, N0, M0.  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


colon dysplasia

A morphologic finding indicating the presence of dysplastic glandular epithelial cells in the colonic mucosa. There is no evidence of invasion.


Aminopterin/Methotrexate embryofetopathy is a syndrome of developmental anomalies characterized by growth deficiency, facial dysmorphism and skull, limb and neural defects secondary to maternal exposure to aminopterin or methotrexate (MTX) during pregnancy.


Lower Urinary Tract Symptoms

Symptoms that result from pathologic processes affecting the urinary bladder and/or urethra. They include urinary frequency and urgency, dysuria, nocturia, incomplete voiding, and poor stream during urination.


Acute repetitive seizure

A fourfold or greater increase of usual seizure frequency within a 3-day period, where the patient demonstrates full recovery between seizure events within the cluster. The seizure cluster should be recognisable by the primary clinician, carer or patient.


Expanded disability status scale score increased


Resting tremor

A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse.


hemophagocytic syndrome

Hemophagocytic syndrome (HPS) is a rare immune disease and a potentially life-threatening disorder characterized by cytokine storm and overwhelming inflammation causing fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia, and hemophagocytosis in bone marrow, liver, spleen or lymph nodes. It can be either primary due to a genetic defect (primary hemophagocytic lymphohistiocytosis), or secondary to malignancies, to infections, most commonly with viruses such as Epstein-Barr virus or cytomegalovirus, human immunodeficiency virus, or to autoimmune disorders such as systemic lupus erythematosus or adult-onset Still disease (secondary hemophagocytic lymphohistiocytosis).


N-terminal prohormone brain natriuretic peptide abnormal


N-terminal prohormone brain natriuretic peptide increased


Environmental Exposure

Exposure to potentially harmful chemical, physical, or biological agents via the environment.


stiff-person syndrome

Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.


Chronic graft versus host disease in intestine


Chronic graft versus host disease in skin


Chronic graft versus host disease in liver


Cutaneous wound

A cutaneous wound is a defined as a disruption of normal anatomic structure and function of the skin that occured owing to an injury of the skin. Wound healing is a dynamic, interactive processinvolving soluble mediators, blood cells, extracellularmatrix, and parenchymal cells. Wound healing has three phases: inflammation, tissue formation, and tissue remodeling, that overlap in time.


Amyloid related imaging abnormality-edema/effusion


Drug-Induced Liver Disease

Damage to the liver tissue due to drug overdose.


Choletec

A radioconjugate composed of the iminodiacetic acid derivative mebrofenin bound to an isotope of the synthetic element technetium (Tc). Upon administration and rapid clearance from the circulation, technetium Tc 99m mebrofenin is secreted into the hepatobiliary system, emitting gamma rays that are detectable with planar scintigraphy or single photon emission computer tomography (SPECT). Mebrofenin has no pharmacological effect at the recommended dosage for diagnostic imagining.


Virus-associated trichodysplasia spinulosa is a rare infectious skin disease characterized by the development of follicular papules with keratin spicules in various parts of the body, predominantly in the face (e.g. nose, eyebrows, auricles), that is due to polyomavirus infection in immunocompromized patients.


steroid-responsive encephalopathy associated with autoimmune thyroiditis


Substance induced psychotic disorder

A psychotic disorder characterized by prominent hallucinations or delusions that have been determined to be etiologically linked to substance use, intoxication or withdrawal.


Amyloid related imaging abnormality-microhaemorrhages and hemosiderin deposits


Inadequate aseptic technique in use of product


Pancreatic steatosis

Fat infiltration in the pancreas.


Immune reconstitution inflammatory syndrome associated tuberculosis


Central Nervous System Fungal Infections


Post-injection delirium sedation syndrome


brachydactyly

A disease characterized by the presence of brachydactyly, including syndromic and non-syndromic forms.


preterm premature rupture of the membranes

A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation.


burkholderia infectious disease

Infections with bacteria of the genus Burkholderia.


Primary malignant neoplasm of unknown site


Recurrent Liver Carcinoma

The reemergence of liver carcinoma after a period of remission.


breast intraductal proliferative lesion

A group of non-invasive epithelial proliferations that occur in the ductal system of the breast. The vast majority of cases arise in the terminal ductal lobular units. This category includes atypical ductal hyperplasia, usual ductal hyperplasia, flat epithelial atypia, and ductal carcinoma in situ. There is an increased risk for subsequent development of invasive breast carcinoma.


invasive lobular breast carcinoma

An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma. The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures.


Postural tremor

A type of tremors that is triggered by holding a limb in a fixed position.


Plasma cell myeloma recurrent

The reemergence of plasma cell myeloma after a period of remission.


adrenal gland cancer

A malignant neoplasm involving the adrenal gland


congenital isolated adrenocorticotropic hormone deficiency

A hypopituitarrium that is characterized by a decreased or absent production of adrenocorticotropic hormone by the pituitary gland.


reversible cerebral vasoconstriction syndrome

Reversible cerebral vasoconstriction syndrome (RCVS) is an infrequent cerebrovascular disorder characterized by severe headaches with or without focal neurological deficits or seizures, and a reversible segmental and multifocal vasoconstriction of cerebral arteries.


clear cell renal carcinoma

A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network. The tumor may metastasize to unusual sites and late metastasis is common.


ovarian teratoma

A non-seminomatous germ cell tumor arising from the ovary. It is characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). According to the level of differentiation of the tissues which comprise the tumor, ovarian teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal type-tissues. Mature ovarian teratomas without a fetal-type component have an excellent outcome. The prognosis of immature ovarian teratomas is related to the grade and stage of the tumor.


Decorticate Posture

A posture characterized by body rigidity, flexion of the arms over the chest, clenched fists,  and extension of the legs. It may indicate cerebral damage.


anal squamous cell carcinoma

A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC.


appendix cancer

A malignant neoplasm involving the vermiform appendix


pancreatic ductal adenocarcinoma

An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor.


anaplastic large cell lymphoma

Anaplastic large cell lymphoma (ALCL) is a rare and aggressive peripheral T-cell non-Hodgkin lymphoma, belonging to the group of CD30-positive lymphoproliferative disorders, which affects lymph nodes and extranodal sites. It is comprised of two sub-types, based on the expression of a protein called anaplastic lymphoma kinase (ALK): ALK positive and ALK negative ALCL.


drug hypersensitivity syndrome

A potentially life-threatening hypersensitivity reaction to a pharmacologic substance that is characterized by rash, lymphadenopathy, fever, hematologic abnormalities and involvement of one or more internal organs.


Pregnancy exposure

Exposure of pregnant women to toxins from any source, such as environmental toxins or chemicals, that may potentially cause problems such as miscarriage, preterm delivery, low birth weight, and, in some cases, developmental delays in infants.


Therapeutic drug monitoring analysis not performed


Therapeutic drug monitoring analysis incorrectly performed


Injury of musculoskeletal system

Damage to the muscles, bones and their supportive structural attachments.


pneumocystosis

Human pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localized to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.


Infection by Pneumocystis jirovecii (disorder)


developmental dysplasia of the hip

A spectrum of hip abnormalities commonly presenting in infancy involving the relationship between the femoral head and the acetabulum and that includes subluxation or dislocation at rest or upon provocation.


Hypothalamic pituitary adrenal axis suppression


Parenteral nutrition associated liver disease


Right ventricular dilatation

Enlargement of the chamber of the right ventricle.


Ectopic pregnancy with contraceptive device


Fetal heart rate deceleration abnormality


Sulfaguanidine

A sulfanilamide antimicrobial agent that is used to treat enteric infections.

A sulfonamide incorporating a guanidine moiety used to block the synthesis of folic acid; mostly used in veterinary medicine


Reduced forced vital capacity

An abnormal reduction in the amount of air a person can expel following maximal inspiration.


Portal fibrosis

Fibroblast proliferation and fiber expansion from the portal areas to the lobule.


language disorder

A category of disorders characterized by an impairment in the development of an individual's language capabilities, which is in contrast to his/her non-verbal intellect.


Device embolization

Movement of a medical device to an unintended location within the body with resulting obstruction of an organ or vessel.


Change in Therapeutic Response

Change in response to treatment or cure of a disorder or disease.


granulomatous dermatitis

An inflammatory reaction of the skin to various organic and inorganic antigens. It is characterized by tumor-like masses or nodules of granulomatous tissue comprised of activated histiocytes, epitheliod cells, and multinucleated giant cells.


Toxic Erythema of Chemotherapy

Painful red or purple patches, edematous plaques or blisters on the hands, feet, extremities or intertriginous regions; the onset can occur days to months after receiving chemotherapy.


Graft versus host disease in gastrointestinal tract


Internal hemorrhage

The presence of hemorrhage within the body.


mast cell activation syndrome

A clinically defined disease states with a largely unknown morphological background. Acute mast cell activation (MCA) is commonly seen in allergic reactions and often leads to the clinical signs and symptoms of anaphylaxis. Severe or even life‐threatening MCA may occur when the burden of mast cells is high and/or these cells are in an hyperactivated state. Mastocytosis may be associated with mast cell activation syndrome (MCAS).


intestinal tuberculosis

A tuberculosis that involves the intestine.


Demodex folliculitis

A demodicidosis that involves the hair follicle.


Disability assessment scale score increased


Drug monitoring procedure incorrectly performed


orbital plasma cell granuloma

A nonspecific tumor-like inflammatory lesion in the orbit of the eye. It is usually composed of mature lymphocytes; plasma cells; macrophages; leukocytes with varying degrees of fibrosis. Orbital pseudotumors are often associated with inflammation of the extraocular muscles (orbital myositis) or inflammation of the lacrimal glands (dacryoadenitis).


Feeding Intolerance

Inability to achieve a full feeding volume.


Unmasking of previously unidentified disease


Poor fine motor coordination

An abnormality of the ability (skills) to perform a precise movement of small muscles with the intent to perform a specific act. Fine motor skills are required to mediate movements of the wrists, hands, fingers, feet, and toes.


Stenosis

Narrowing or stricture of a vessel, duct or canal.


central nervous system lupus

Inflammation that includes the brain, spinal cord and surrounding tissues secondary to systemic lupus erythematosus (SLE); it is associated with neurological and/or psychiatric features.


Documented hypersensitivity to administered product


Enbucrilate

A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.

A macromolecule composed of repeating butyl 2-cyanopropanoate units.


Wrong technique in product usage process


Unintentional use for unapproved indication


Prescription drug used without a prescription


Delayed Graft Function

The need for dialysis within a week of kidney transplant.


BCGosis

Distant, or disseminated infection with Bacillus Calmette-Guerin (BCG) following vaccination associated with failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis.


Perforation

A hole or opening made through a membrane or other tissue or material.


Osteonecrosis of external auditory canal


Hyperinsulinemic hypoglycemia

An increased concentration of insulin combined with a decreased concentration of glucose in the blood.


Intrusive thoughts

An unwelcome and persistent idea, image or thought that is upsetting to an individual.


infantile apnea

Infantile apnea is a cessation of respiratory air flow that may affect newborns or older children because of neurological impairment of the respiratory rhythm or obstruction of air flow through the air passages. The symptoms include cyanosis, pallor or bradycardia and snoring in case of obstructive apnea.


Epileptic encephalopathy

A condition in which epileptiform abnormalities are believed to contribute to the progressive disturbance in cerebral function. Epileptic encephalaopathy is characterized by (1) electrographic EEG paroxysmal activity that is often aggressive, (2) seizures that are usually multiform and intractable, (3) cognitive, behavioral and neurological deficits that may be relentless, and (4) sometimes early death.


Vitreous haze

Vitreous haze is the obscuration of fundus details by vitreous cells and protein exudation.


Cornea verticillata

Golden brown or gray deposits with a clockwise, whorl-like distribution in the inferior interpalpebal portion of the cornea.


Accidental exposure to product packaging


Immune-mediated adverse reaction

An adverse event resulting from an immune system reaction to a drug or device. It can affect any organ or system.


ureterolithiasis

The presence of a calculus in the ureter of the kidney; this is most often composed of mineral salts and proteins.


neurosarcoidosis

A sarcoidosis that involves the nervous system.


paraneoplastic limbic encephalitis

A rare disorder characterized by degenerative changes in the limbic area of the brain. Causes include infections and autoimmune conditions; it may also manifest as a paraneoplastic syndrome, most often caused by small cell lung carcinoma. Signs and symptoms include behavioral changes, hallucinations and dementia.


pathological gambling

A disorder characterized by a preoccupation with gambling and the excitement that gambling with increasing risk provides. Pathological gamblers are unable to cut back on their gambling, despite the fact that it may lead them to lie, steal, or lose a significant relationship, job, or educational opportunity.


Neurasthenia

An episode of acute, severe anxiety or depression associated with an inability to function as normal.


Fractional exhaled nitric oxide increased


Behavioral and psychological symptoms of dementia


cholesterol embolism

Blocking of a blood vessel by cholesterol-rich atheromatous deposits, generally occurring in the flow from a large artery to small arterial branches. It is also called arterial-arterial embolization or atheroembolism which may be spontaneous or iatrogenic. Patients with spontaneous atheroembolism often have painful, cyanotic digits of acute onset.


subacute lymphocytic thyroiditis

Thyroiditis associated with painless enlargement of the thyroid gland. It occurs more frequently in females and is characterized by alterations between hyperthyroidism and hypothyroidism and the eventual return to normal thyroid gland function.


Transformation to acute myeloid leukemia


Drug effective for unapproved indication


EBV positive mucocutaneous ulcer

A rare Epstein-Barr virus-positive B-cell lymphoproliferative disorder which presents as an ulcerative mucocutaneous lesion. It is associated with immune suppression, including age-related and drug-induced immunosuppression.


Loss of personal independence in daily activities


Pancreatitis due to pancreatic duct obstruction


Cutaneous lymphoma

A lymphoma involving the skin.


Neoplasm, Residual

Evidence for remaining tumor following primary treatment that is only apparent using highly sensitive techniques.


hairy tongue

A benign condition affecting the dorsum of the tongue. It is characterized by defective desquamation resulting in elongation of the filiform papillae. The dorsum of the tongue has a furry appearance and is usually stained black.


Sickness

A state of ill health, bodily malfunction, or discomfort.


malakoplakia

Malakoplakia is a chronic multisystem granulomatous inflammatory disease characterized by the presence of single or multiple soft plaques on various organs of the body.


vascular hyalinosis

A syndrome characterized by progressive hyalinosis involving capillaries and often arterioles and small veins of the digestive tract, kidneys, and idiopathic cerebral calcifications. It has been described in three sisters born to non-consanguineous parents. All three patients also had poikilodermia and graying hair, as well as severe diarrhea, rectal bleeding, malabsorption and subarachnoid hemorrhage.


Gastrointestinal vascular malformation hemorrhagic


Increased reactive oxygen species production

An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage.


B-cell aplasia

A condition characterized by extremely low B-cell counts. It occurs when anti-CD19 CAR T-cells attack and kill CD19-expressing B-lymphocytes.


Product administered at inappropriate site


phaeohyphomycosis

An opportunistic fungal infection caused by any of a variety of normally saprophytic fungi with hyaline hyphal elements. For example, Fusarium spp. infect neutropenic patients to cause pneumonia, fungemia, and disseminated infection with cutaneous lesions.


Body Substance Discharge

The leakage of a substance from an orifice or wound.


Incorrect route of product administration


Product use in unapproved therapeutic environment


Inappropriate schedule of product administration


Intercepted product administration error


Product administered to patient of inappropriate age


Incorrect product administration duration


central nervous system vasculitis

Vasculitis affecting the blood vessels of the brain and/or spinal cord.


Plasma cell myeloma refractory

Plasma cell myeloma that is resistant to treatment.


Vogt-Koyanagi-Harada disease

A bilateral, chronic, diffuse granulomatous panuveitis typically characterized by serous retinal detachment and frequently associated with neurological (meningitis), auditory, and dermatological alterations.


Neonatal seizure

A seizure occurring within the neonatal period (28 days beyond the full term date).


Oligoarthritis

A type of arthritis that affects up to four joints in the first six months of disease.


Philadelphia positive chronic myeloid leukemia


Autoimmune inflammation of skeletal muscle


Post 5-alpha-reductase inhibitor syndrome


Undetermined manner of death, suicide suspected


Taste Disorders

Conditions characterized by an alteration in the ability to perceive taste.


New onset diabetes after transplantation


Infusion related hypersensitivity reaction


Cerebral venous sinus thrombosis

An intracranial thrombosis of the venous sinuses. These typically present with headache, seizures or venous stroke secondary to raised cerebral venous pressure. Cerebral venous sinus thromboses usually affect larger areas of brain parenchyma than those affected by cerebral vein thromboses.


Bronchiolitis Obliterans Syndrome

Bronchiolitis obliterans following lung or allogeneic hematopoietic cell transplantation.


cell-associated neurotoxicity

Neurotoxicity associated with immune effector cell therapy. It may be characterized by aphasia, altered level of consciousness, motor weakness, seizures, and cerebral edema.


Subcapsular renal hematoma

A collection of blood between the renal capsule and the renal parenchyma.


Chronic graft versus host disease in eye


Failure of child resistant product closure


Congestive hepatopathy

Chronic passive congestion of the liver secondary to right heart failure. Elevation of central venous pressure leads to restriction of the hepatic circulation. Prolonged hepatic venous pressure may lead to liver fibrosis and cirrhosis.


Biliary tract obstruction

Obstruction affecting the biliary tree.


Disseminated varicella zoster virus infection


Mercuric Chloride

Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.

A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.


long COVID-19

A chronic disease triggered by acute COVID-19 infection that is characterized by persistent symptoms following the acute phase of the SARS-CoV-2 infection, which may include fatigue, coughing, dyspnea, clouding of mentation, sleep disturbances, exercise intolerance and autonomic symptoms including tachycardia upon mild exercise or standing, night sweats, temperature dysregulation, gastroparesis, constipation or loose stools, and peripheral vasoconstriction.


ABCC8_RAT ATP-binding cassette sub-family C member 8 (sprot)

An ATP-binding cassette sub-family C member 8 that is encoded in the genome of rat.


TRPM4_RAT Transient receptor potential cation channel subfamily M member 4 (sprot)

A transient receptor potential cation channel subfamily M member 4 that is encoded in the genome of rat.


Kojic acid

A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae.


EYA2_HUMAN Eyes absent homolog 2 (sprot)

An eyes absent homolog 2 that is encoded in the genome of human.


BT3A1_HUMAN Butyrophilin subfamily 3 member A1 (sprot)

A butyrophilin subfamily 3 member A1 that is encoded in the genome of human.


FFAR3_HUMAN Free fatty acid receptor 3 (sprot)

A free fatty acid receptor 3 that is encoded in the genome of human.


SHIP2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (sprot)

A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 that is encoded in the genome of human.


Estramustine phosphate

A steroid phosphate which is the 17-O-phospho derivative of estramustine.


CAH11_HUMAN Carbonic anhydrase-related protein 11 (sprot)

A carbonic anhydrase-related protein 11 that is encoded in the genome of human.


DDAH1_HUMAN N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (sprot)

An N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 that is encoded in the genome of human.


RASK_HUMAN GTPase KRas (sprot)

A GTPase KRas that is encoded in the genome of human.


HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (sprot)

An MHC class I histocompatibility antigen A alpha chain that is encoded in the genome of human.


EVANS BLUE

An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.


LUCI_PHOPY Luciferin 4-monooxygenase (sprot)


Indoprofen

A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)

A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.


PPBI_HUMAN Intestinal-type alkaline phosphatase (sprot)

An intestinal alkaline phosphatase that is encoded in the genome of human.


GTR2_HUMAN Solute carrier family 2, facilitated glucose transporter member 2 (sprot)

A solute carrier family 2, facilitated glucose transporter member 2 that is encoded in the genome of human.


MIF_HUMAN Macrophage migration inhibitory factor (sprot)

A macrophage migration inhibitory factor that is encoded in the genome of human.


PLCG1_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (sprot)

A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 that is encoded in the genome of human.


Thiram

A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.

An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.


LYOX_HUMAN Protein-lysine 6-oxidase (sprot)

A protein-lysine 6-oxidase that is encoded in the genome of human.


KDM5A_HUMAN Lysine-specific demethylase 5A (sprot)

A lysine-specific demethylase 5A that is encoded in the genome of human.


STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta (sprot)

A signal transducer and activator of transcription 1 that is encoded in the genome of human.


TTPA_HUMAN Alpha-tocopherol transfer protein (sprot)

An alpha-tocopherol transfer protein that is encoded in the genome of human.


STA5B_HUMAN Signal transducer and activator of transcription 5B (sprot)

A signal transducer and activator of transcription 5b that is encoded in the genome of human.


NR1H2_HUMAN Oxysterols receptor LXR-beta (sprot)

An oxysterols receptor LXR-beta that is encoded in the genome of human.


Ubenimex

growth inhibitor; RN given refers to ((L-Leu)-(S-(R*,S*)))-isomer; structure


PSA_HUMAN Puromycin-sensitive aminopeptidase (sprot)

A puromycin-sensitive aminopeptidase that is encoded in the genome of human.


GSTO1_HUMAN Glutathione S-transferase omega-1 (sprot)

A glutathione S-transferase omega-1 that is encoded in the genome of human.


ADA2C_MOUSE Alpha-2C adrenergic receptor (sprot)

An alpha-2C adrenergic receptor that is encoded in the genome of mouse.


NRAM_I63A3 Neuraminidase (sprot)

A neuraminidase subtype N8 (Influenza A virus) that is encoded in the genome of the H3N8 strain strain A/Duck/Ukraine/1/1963.


NR1H3_HUMAN Oxysterols receptor LXR-alpha (sprot)

An oxysterols receptor LXR-alpha that is encoded in the genome of human.


ELAV3_HUMAN ELAV-like protein 3 (sprot)

An ELAV-like protein 3 that is encoded in the genome of human.


TEAD4_HUMAN Transcriptional enhancer factor TEF-3 (sprot)

A transcriptional enhancer factor TEF-3 that is encoded in the genome of human.


Niflumic acid

An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.


Q4QEW7_LEIMA Dihydroorotate dehydrogenase (fumarate) (trembl)


DYR_STRPN Dihydrofolate reductase (sprot)


BRDT_HUMAN Bromodomain testis-specific protein (sprot)

A bromodomain testis-specific protein that is encoded in the genome of human.


CP51_TRYCC Sterol 14-alpha demethylase (sprot)

A protein that is a translation product of any of the 2 copies of the CYP51 gene in Trypanosoma cruzi strain CL Brener.


PK3C3_HUMAN Phosphatidylinositol 3-kinase catalytic subunit type 3 (sprot)

A phosphatidylinositol 3-kinase catalytic subunit type 3 that is encoded in the genome of human.


LOXL4_HUMAN Lysyl oxidase homolog 4 (sprot)

A lysyl oxidase homolog 4 that is encoded in the genome of human.


NEK1_HUMAN Serine/threonine-protein kinase Nek1 (sprot)

A serine/threonine-protein kinase Nek1 that is encoded in the genome of human.


PXL2A_HUMAN Peroxiredoxin-like 2A (sprot)

A peroxiredoxin-like 2A that is encoded in the genome of human.


FTO_HUMAN Alpha-ketoglutarate-dependent dioxygenase FTO (sprot)

An alpha-ketoglutarate-dependent dioxygenase FTO that is encoded in the genome of human.


CISD1_HUMAN CDGSH iron-sulfur domain-containing protein 1 (sprot)

A CDGSH iron-sulfur domain-containing protein 1 that is encoded in the genome of human.


POLK_HUMAN DNA polymerase kappa (sprot)

A DNA polymerase kappa that is encoded in the genome of human.


LOXL2_HUMAN Lysyl oxidase homolog 2 (sprot)

A lysyl oxidase homolog 2 that is encoded in the genome of human.


TRPC3_HUMAN Short transient receptor potential channel 3 (sprot)

A short transient receptor potential cation channel TRPC3 that is encoded in the genome of human.


Clemizole

A member of the class of  benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.


ACTHR_MOUSE Adrenocorticotropic hormone receptor (sprot)

An adrenocorticotropic hormone receptor that is encoded in the genome of mouse.


Q8IAU3_PLAF7 Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase (trembl)


P2RX7_HUMAN P2X purinoceptor 7 (sprot)

A P2X purinoceptor 7 that is encoded in the genome of human.


Oxatomide

orally active H1-histamine receptor antagonist used to treat chronic urticaria and allergic rhinitis

A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug.


TRPC6_HUMAN Short transient receptor potential channel 6 (sprot)

A short transient receptor potential channel 6 that is encoded in the genome of human.


TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 (sprot)

A transient receptor potential cation channel TRPV2 that is encoded in the genome of human.


GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1 (sprot)

A gamma-aminobutyric acid receptor subunit alpha-1 that is encoded in the genome of human.


GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)

A gamma-aminobutyric acid receptor subunit alpha-2 that is encoded in the genome of human.


GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)

A gamma-aminobutyric acid receptor subunit alpha-3 that is encoded in the genome of human.


GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5 (sprot)

A gamma-aminobutyric acid receptor subunit alpha-5 that is encoded in the genome of human.


GBRG1_HUMAN Gamma-aminobutyric acid receptor subunit gamma-1 (sprot)

A gamma-aminobutyric acid receptor subunit gamma-1 that is encoded in the genome of human.


GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2 (sprot)

A gamma-aminobutyric acid receptor subunit gamma-2 that is encoded in the genome of human.


GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3 (sprot)

A gamma-aminobutyric acid receptor subunit gamma-3 that is encoded in the genome of human.


CDD_HUMAN Cytidine deaminase (sprot)

A cytidine deaminase that is encoded in the genome of human.


TNR17_HUMAN Tumor necrosis factor receptor superfamily member 17 (sprot)

A tumor necrosis factor receptor superfamily member 17 that is encoded in the genome of human.


FCGR1_HUMAN High affinity immunoglobulin gamma Fc receptor I (sprot)

A high affinity immunoglobulin gamma Fc receptor I that is encoded in the genome of human.


FCG3A_HUMAN Low affinity immunoglobulin gamma Fc region receptor III-A (sprot)

A low affinity immunoglobulin gamma Fc region receptor III-A that is encoded in the genome of human.


IGHG1_HUMAN Immunoglobulin heavy constant gamma 1 (sprot)

An immunoglobulin heavy constant gamma 1 that is encoded in the genome of human.


IGHG2_HUMAN Immunoglobulin heavy constant gamma 2 (sprot)

An immunoglobulin heavy constant gamma 2 that is encoded in the genome of human.


IGHG3_HUMAN Immunoglobulin heavy constant gamma 3 (sprot)

An immunoglobulin heavy constant gamma 3 that is encoded in the genome of human.


IGHG4_HUMAN Immunoglobulin heavy constant gamma 4 (sprot)

An immunoglobulin heavy constant gamma 4 that is encoded in the genome of human.


KLK3_HUMAN Prostate-specific antigen (sprot)

A prostate-specific antigen that is encoded in the genome of human.


HAOX1_HUMAN 2-Hydroxyacid oxidase 1 (sprot)

A 2-hydroxyacid oxidase 1 that is encoded in the genome of human.


Alexidine

until June 1975 was mistakenly treated as synonym for chlorhexidine; RN given refers to parent cpd

An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge.


PTPM1_HUMAN Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (sprot)

A protein-tyrosine phosphatase mitochondrial 1 that is encoded in the genome of human.


NEK10_HUMAN Serine/threonine-protein kinase Nek10 (sprot)

A serine/threonine-protein kinase Nek10 that is encoded in the genome of human.


ANGL3_HUMAN Angiopoietin-related protein 3 (sprot)

An angiopoietin-related protein 3 that is encoded in the genome of human.


FOLH1_HUMAN Glutamate carboxypeptidase 2 (sprot)

A glutamate carboxypeptidase 2 that is encoded in the genome of human.


Q6FTN8_CANGA 1,3-beta-glucan synthase (trembl)


P87204_ASPFM 1,3-beta-glucan synthase (trembl)


CP4AB_HUMAN Cytochrome P450 4A11 (sprot)

A cytochrome P450 4A11 that is encoded in the genome of human.


A0A113T0T6_PLABE Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, putative (trembl)


Acediasulfone

antibacterial drug for treatment of ear infections


Sodium propionate

An organic sodium salt comprising equal numbers of sodium and propionate ions.


FFAR3_RAT Free fatty acid receptor 3 (sprot)

A free fatty acid receptor 3 that is encoded in the genome of rat.


B3DH72_DANRE Opioid receptor, delta 1b (trembl)


C1KIQ2_9HEPC Genome polyprotein (Fragment) (trembl)


E1BI31_BOVIN Dipeptidyl peptidase 9 (trembl)


G3HDX1_CRIGR Alpha-1B adrenergic receptor (trembl)


K7XJL6_9HEPC Genome polyprotein (Fragment) (trembl)


M9TGV3_MYCTX Enoyl-[acyl-carrier-protein] reductase [NADH] (trembl)


Pyrvinium

A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a  anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.


SYNJ2_HUMAN Synaptojanin-2 (sprot)

A synaptojanin-2 that is encoded in the genome of human.


GLP1R_MOUSE Glucagon-like peptide 1 receptor (sprot)

A glucagon-like peptide 1 receptor that is encoded in the genome of mouse.


SYNJ1_HUMAN Synaptojanin-1 (sprot)

A synaptojanin-1 that is encoded in the genome of human.


O90781_9PLVG HIV-1 protease (Fragment) (trembl)


NRAM_I71A1 Neuraminidase (sprot)

A neuraminidase subtype N2 (Influenza A virus) that is encoded in the genome of the H3N2 strain A/Memphis/1/1971.


Azaribine

pyrimidine analogue; anti-metabolite used in psoriasis & mycosis fungoides

A N-glycosyl-1,2,4-triazine that is 6-azauridine acetylated at positions 2', 3' and 5' on the sugar ring. It is a prodrug for 6-azauridine and is used for treatment of psoriasis.


PYRF_YEAST Orotidine 5'-phosphate decarboxylase (sprot)

A protein that is a translation product of the URA3 gene in yeast.


M2_I000F Matrix protein 2 (sprot)

An influenzavirus matrix protein 2 that is encoded in the genome of the H7N7 strain A/Chicken/Weybridge.


NQO1_RAT NAD(P)H dehydrogenase [quinone] 1 (sprot)

An NAD(P)H dehydrogenase [quinone] 1 that is encoded in the genome of rat.


Ractopamine

A diastereoisomeric mixture of approximately equal amounts of all four possible diastereoisomers of 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol. A beta-adrenergic agonist, it is used (generally as the hydrochloride salt) as a feed additive for use in pigs and other livestock to promote protein deposition, resulting in leaner meat. The R,R diastereoisomer, butopamine, is responsible for most of the leanness-enhancing effects. While use of ractopamine has been banned in over 120 countries including throughout the EU, in the US it used in an estimated 80% of all beef, pork and turkey production.


ADRB2_HUMAN Beta-2 adrenergic receptor (sprot)

A beta-2 adrenergic receptor that is encoded in the genome of human.


Strychnine

An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.

A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.


GLRA1_RAT Glycine receptor subunit alpha-1 (sprot)

A glycine receptor subunit alpha-1 that is encoded in the genome of rat.


ACE_MOUSE Angiotensin-converting enzyme (sprot)

An angiotensin-converting enzyme that is encoded in the genome of mouse.


M2_I72A8 Matrix protein 2 (sprot)

An influenzavirus matrix protein 2 that is encoded in the genome of the H3N2 strain A/Udorn/1972.


LIPC_HUMAN Hepatic triacylglycerol lipase (sprot)

A hepatic triacylglycerol lipase that is encoded in the genome of human.


SCN4A_RAT Sodium channel protein type 4 subunit alpha (sprot)

A sodium channel protein type 4 subunit alpha that is encoded in the genome of rat.


ARBK1_BOVIN Beta-adrenergic receptor kinase 1 (sprot)


LKHA4_MOUSE Leukotriene A-4 hydrolase (sprot)

A leukotriene A-4 hydrolase that is encoded in the genome of mouse.


LASR_PSEAE Transcriptional activator protein LasR (sprot)

A protein that is a translation product of the lasR gene in Pseudomonas aeruginosa PAO1.


N-ACETYL-beta-D-GLUCOSAMINE

An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.


KLRBA_RAT Killer cell lectin-like receptor subfamily B member 1A (sprot)

A protein that is a translation product of the Klrb1a gene in rat.


BRAF_MOUSE Serine/threonine-protein kinase B-raf (sprot)

A B-Raf proto-oncogene serine/threonine-protein kinase that is encoded in the genome of mouse.


PSB8_MOUSE Proteasome subunit beta type-8 (sprot)

A proteasome subunit beta type-8 that is encoded in the genome of mouse.


C11B2_RAT Cytochrome P450 11B2, mitochondrial (sprot)

A cytochrome P450 11B that is a translation product of the Cyp11b2 gene in rat.


SDHA_HUMAN Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sprot)

A succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial that is encoded in the genome of human.


HPPD_RAT 4-hydroxyphenylpyruvate dioxygenase (sprot)

A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of rat.


MC3R_MOUSE Melanocortin receptor 3 (sprot)

A melanocortin receptor 3 that is encoded in the genome of mouse.


GLYM_HUMAN Serine hydroxymethyltransferase, mitochondrial (sprot)

A serine hydroxymethyltransferase, mitochondrial that is encoded in the genome of human.


LOX15_MOUSE Polyunsaturated fatty acid lipoxygenase ALOX15 (sprot)

A polyunsaturated fatty acid lipoxygenase ALOX15 that is encoded in the genome of mouse.


PSB10_HUMAN Proteasome subunit beta type-10 (sprot)

A proteasome subunit beta type-10 that is encoded in the genome of human.


MC5R_MOUSE Melanocortin receptor 5 (sprot)

A melanocortin receptor 5 that is encoded in the genome of mouse.


ROLITETRACYCLINE

A derivative of tetracycline in which the amide function is substituted with a pyrrolidinomethyl group.


RAD52_HUMAN DNA repair protein RAD52 homolog (sprot)

A DNA repair protein RAD52 homolog that is encoded in the genome of human.


CATC_HUMAN Dipeptidyl peptidase 1 (sprot)

A dipeptidyl peptidase 1 that is encoded in the genome of human.


ASIC1_RAT Acid-sensing ion channel 1 (sprot)

An acid-sensing ion channel 1 that is encoded in the genome of rat.


SYI_THET8 Isoleucine--tRNA ligase (sprot)


Diethyldithiocarbamic acid

A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.

A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.


GSDMD_HUMAN Gasdermin-D (sprot)

A gasdermin-D that is encoded in the genome of human.


T2R40_HUMAN Taste receptor type 2 member 40 (sprot)

A taste receptor type 2 member 40 that is encoded in the genome of human.


T2R41_HUMAN Taste receptor type 2 member 41 (sprot)

A taste receptor type 2 member 41 that is encoded in the genome of human.


T2R30_HUMAN Taste receptor type 2 member 30 (sprot)

A taste receptor type 2 member 30 that is encoded in the genome of human.


T2R20_HUMAN Taste receptor type 2 member 20 (sprot)

A taste receptor type 2 member 20 that is encoded in the genome of human.


T2R60_HUMAN Taste receptor type 2 member 60 (sprot)

A taste receptor type 2 member 60/135 that is encoded in the genome of human.


An undecaprenyl-diphosphatase that is encoded in the genome of Escherichia coli K-12.


AAA1_RAT Asc-type amino acid transporter 1 (sprot)

An asc-type amino acid transporter 1 that is encoded in the genome of rat.


Oleandrin

A steroid saponin that consists of oleandrigenin having a 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl residue attached to the oxygen function at position 3.


NOTC1_MOUSE Neurogenic locus notch homolog protein 1 (sprot)

A neurogenic locus notch homolog protein 1 that is encoded in the genome of mouse.


PGFRB_RAT Platelet-derived growth factor receptor beta (sprot)

A beta-type platelet-derived growth factor receptor that is encoded in the genome of rat.


Q0P8E1_CAMJE Pyruvate-flavodoxin oxidoreductase (trembl)


Q0ZMF1_9HEPC Genome polyprotein (Fragment) (trembl)


NTCP_HUMAN Hepatic sodium/bile acid cotransporter (sprot)

A hepatic sodium/bile acid cotransporter that is encoded in the genome of human.


TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (sprot)

A transcriptional enhancer factor TEF-4 that is encoded in the genome of human.


ADRB3_MACMU Beta-3 adrenergic receptor (sprot)


Q28731_RABIT Thrombin (Fragment) (trembl)


A bright bluish pink compound that has been used as a dye, biological stain, and diagnostic aid.

A xanthene dye that is fluorescein bearing bromine substituents at positions 2', 4', 5' and 7' (on the xanthene ring) and iodine substituents at position 2, 3, 4, and 5 (on the phenyl ring). The dipotassium salt is the biological stain 'rose bengal'.


SECA2_STAA8 Protein translocase subunit SecA 2 (sprot)

A protein that is a translation product of the secA2 gene in Staphylococcus aureus subsp. aureus NCTC 8325.


IMDH_CRYNJ Inosine-5'-monophosphate dehydrogenase (sprot)


SGMR2_RAT Sigma intracellular receptor 2 (sprot)

A sigma intracellular receptor 2 that is encoded in the genome of rat.


Ifenprodil

NMDA receptor antagonist; RN given refers to parent cpd without isomeric designation; structure


ZN664_CAVPO Zinc finger protein 664 (sprot)


SARM1_HUMAN NAD(+) hydrolase SARM1 (sprot)

An NAD(+) hydrolase SARM1 that is encoded in the genome of human.


T2R42_HUMAN Taste receptor type 2 member 42 (sprot)

A taste receptor type 2 member 42 that is encoded in the genome of human.


Q7T664_HRV1A Genome polyprotein (Fragment) (trembl)


Q8I1R6_PLAF7 Bifunctional dihydrofolate reductase-thymidylate synthase (trembl)


MLKL_HUMAN Mixed lineage kinase domain-like protein (sprot)

A mixed lineage kinase domain-like protein that is encoded in the genome of human.


Diosmetin

A monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities.


IPMK_HUMAN Inositol polyphosphate multikinase (sprot)

An inositol polyphosphate multikinase that is encoded in the genome of human.


GNRHR_MACMU Gonadotropin-releasing hormone receptor (Fragment) (sprot)


Q91RS4_9HEPC Genome polyprotein (Fragment) (trembl)


Benziodarone

minor descriptor (75-89); on-line & INDEX MEDICUS search BENZOFURANS (68-89) & IODOBENZOATES (74)


EYA3_HUMAN Eyes absent homolog 3 (sprot)

An eyes absent homolog 3 that is encoded in the genome of human.


DOHH_HUMAN Deoxyhypusine hydroxylase (sprot)

A deoxyhypusine hydroxylase that is encoded in the genome of human.


L-mimosine

3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.

An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.


Enoxolone

An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.

A pentacyclic triterpenoid that is olean-12-ene substituted by a hydroxy group at position 3, an oxo group at position 11 and a carboxy group at position 30.


LGUL_MOUSE Lactoylglutathione lyase (sprot)

A lactoylglutathione lyase that is encoded in the genome of mouse.


BRD9_HUMAN Bromodomain-containing protein 9 (sprot)

A bromodomain-containing protein 9 that is encoded in the genome of human.


Q9N6S8_PLAFA Cysteine proteinase falcipain 2a (trembl)


Gamma-Aminobutyric Acid

The most common inhibitory neurotransmitter in the central nervous system.

A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.


S6A13_HUMAN Sodium- and chloride-dependent GABA transporter 2 (sprot)

A sodium- and chloride-dependent GABA transporter 2 that is encoded in the genome of human.


T2R16_HUMAN Taste receptor type 2 member 16 (sprot)

A taste receptor type 2 member 16 that is encoded in the genome of human.


T2R13_HUMAN Taste receptor type 2 member 13 (sprot)

A taste receptor type 2 member 13 that is encoded in the genome of human.


TA2R8_HUMAN Taste receptor type 2 member 8 (sprot)

A taste receptor type 2 member 8 that is encoded in the genome of human.


TA2R5_HUMAN Taste receptor type 2 member 5 (sprot)

A taste receptor type 2 member 5 that is encoded in the genome of human.


TA2R3_HUMAN Taste receptor type 2 member 3 (sprot)

A taste receptor type 2 member 3 that is encoded in the genome of human.


TA2R1_HUMAN Taste receptor type 2 member 1 (sprot)

A taste receptor type 2 member 1/119 that is encoded in the genome of human.


ERAP1_HUMAN Endoplasmic reticulum aminopeptidase 1 (sprot)

An endoplasmic reticulum aminopeptidase 1 that is encoded in the genome of human.


Q9WJQ2_9HIV1 Reverse transcriptase protein (Fragment) (trembl)


CP46A_HUMAN Cholesterol 24-hydroxylase (sprot)

A cytochrome P450 46A1 that is encoded in the genome of human.


Q9YQ30_9PLVG HIV-1 protease (Fragment) (trembl)


Q9Z1J7_RAT Amino acid transporter (trembl)


Asparagine

A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

An optically active form of asparagine having L-configuration.


INAR1_HUMAN Interferon alpha/beta receptor 1 (sprot)

An interferon-alpha/beta receptor alpha chain that is encoded in the genome of human.


IL17F_HUMAN Interleukin-17F (sprot)

An interleukin-17F that is encoded in the genome of human.


IL13_HUMAN Interleukin-13 (sprot)

An interleukin-13 that is encoded in the genome of human.


ANPRB_HUMAN Atrial natriuretic peptide receptor 2 (sprot)

An atrial natriuretic peptide receptor 2 that is encoded in the genome of human.


MPRI_HUMAN Cation-independent mannose-6-phosphate receptor (sprot)

A cation-independent mannose-6-phosphate receptor that is encoded in the genome of human.


C5AR1_HUMAN C5a anaphylatoxin chemotactic receptor 1 (sprot)

A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human.


LIPP_RAT Pancreatic triacylglycerol lipase (sprot)

A pancreatic triacylglycerol lipase that is encoded in the genome of rat.


MC4R_RAT Melanocortin receptor 4 (sprot)

A melanocortin receptor 4 that is encoded in the genome of rat.


A3EZJ3_9HEPC Genome polyprotein (Fragment) (trembl)


G4VFD7_SCHMA Dihydroorotate dehydrogenase (quinone), mitochondrial (trembl)


R1AB_MERS1 Replicase polyprotein 1ab (sprot)


BUB1_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 (sprot)

A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human.


SMC2_HUMAN Structural maintenance of chromosomes protein 2 (sprot)

A structural maintenance of chromosomes protein 2 that is encoded in the genome of human.


AT2A1_RABIT Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (sprot)


HMOX1_RAT Heme oxygenase 1 (sprot)

A heme oxygenase 1 that is encoded in the genome of rat.


M2_I34A1 Matrix protein 2 (sprot)

An influenzavirus matrix protein 2 that is encoded in the genome of the H1N1 strain A/Puerto Rico/8/1934.


BGLR_HUMAN Beta-glucuronidase (sprot)

A beta-glucuronidase that is encoded in the genome of human.


DAPA_ECOLI 4-hydroxy-tetrahydrodipicolinate synthase (sprot)

A 4-hydroxy-tetrahydrodipicolinate synthase that is encoded in the genome of Escherichia coli K-12.


AMY1A_HUMAN Alpha-amylase 1A (sprot)

A protein that is a translation product of the AMY1A gene in human.


ERCC2_HUMAN General transcription and DNA repair factor IIH helicase subunit XPD (sprot)

A general transcription and DNA repair factor IIH helicase subunit XPD that is encoded in the genome of human.


PUR6_HUMAN Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (sprot)

A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is encoded in the genome of human.


PPAC_HUMAN Low molecular weight phosphotyrosine protein phosphatase (sprot)

A low molecular weight phosphotyrosine protein phosphatase that is encoded in the genome of human.


PEBP1_HUMAN Phosphatidylethanolamine-binding protein 1 (sprot)

A phosphatidylethanolamine-binding protein 1 that is encoded in the genome of human.


PUR9_HUMAN Bifunctional purine biosynthesis protein ATIC (sprot)

A bifunctional purine biosynthesis protein ATIC that is encoded in the genome of human.


CHLE_CANLF Cholinesterase (Fragment) (sprot)


VDR_MOUSE Vitamin D3 receptor (sprot)

A vitamin D3 receptor that is encoded in the genome of mouse.


PI42A_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (sprot)

A phosphatidylinositol 5-phosphate 4-kinase type-2 alpha that is encoded in the genome of human.


EFTU_HUMAN Elongation factor Tu, mitochondrial (sprot)

An elongation factor Tu, mitochondrial that is encoded in the genome of human.


SYCC_HUMAN Cysteine--tRNA ligase, cytoplasmic (sprot)

A cysteine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


RB27A_HUMAN Ras-related protein Rab-27A (sprot)

A Ras-related protein Rab-27A that is encoded in the genome of human.


RAN_HUMAN GTP-binding nuclear protein Ran (sprot)

A GTP-binding nuclear protein Ran that is encoded in the genome of human.


EYA3_MOUSE Eyes absent homolog 3 (sprot)

An eyes absent homolog 3 that is encoded in the genome of mouse.


ALK_MOUSE ALK tyrosine kinase receptor (sprot)

An ALK tyrosine kinase receptor that is encoded in the genome of mouse.


CDKL1_HUMAN Cyclin-dependent kinase-like 1 (sprot)

A cyclin-dependent kinase-like 1 that is encoded in the genome of human.


TADBP_HUMAN TAR DNA-binding protein 43 (sprot)

A TAR DNA-binding protein 43 that is encoded in the genome of human.


ILK_HUMAN Integrin-linked protein kinase (sprot)

An integrin-linked protein kinase that is encoded in the genome of human.


CLPP_STAA8 ATP-dependent Clp protease proteolytic subunit (sprot)

An ATP-dependent Clp protease proteolytic subunit that is encoded in the genome of Staphylococcus aureus subsp. aureus NCTC 8325.


ADCK5_HUMAN Uncharacterized aarF domain-containing protein kinase 5 (sprot)

An uncharacterized aarF domain-containing protein kinase 5 that is encoded in the genome of human.


RABL3_HUMAN Rab-like protein 3 (sprot)

A Rab-like protein 3 that is encoded in the genome of human.


FZD8_MOUSE Frizzled-8 (sprot)

A frizzled-8 that is encoded in the genome of mouse.


JAK2_RAT Tyrosine-protein kinase JAK2 (sprot)

A tyrosine-protein kinase JAK2 that is encoded in the genome of rat.


ACD10_HUMAN Acyl-CoA dehydrogenase family member 10 (sprot)

An acyl-CoA dehydrogenase family member 10 that is encoded in the genome of human.


Q6QLK5_9HIV1 Envelope glycoprotein gp160 (trembl)


Bithionol

Halogenated anti-infective agent that is used against trematode and cestode infestations.

An aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, but withdrawn after being shown to be a potent photosensitizer with the potential to cause serious skin disorders.


YJ005_HUMAN Uncharacterized protein FLJ45252 (sprot)

An AAK1 gene translation product (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZSR9-1.


ACD11_HUMAN Acyl-CoA dehydrogenase family member 11 (sprot)

An acyl-CoA dehydrogenase family member 11 that is encoded in the genome of human.


STRAA_HUMAN STE20-related kinase adapter protein alpha (sprot)

A STE20-related kinase adapter protein alpha that is encoded in the genome of human.


Q86GS5_PLAFA Adenosine deaminase (trembl)


NLRP3_MOUSE NACHT, LRR and PYD domains-containing protein 3 (sprot)

A NACHT, LRR and PYD domains-containing protein 3 that is encoded in the genome of mouse.


FPPS_MOUSE Farnesyl pyrophosphate synthase (sprot)

A farnesyl pyrophosphate synthase that is encoded in the genome of mouse.


DDX1_HUMAN ATP-dependent RNA helicase DDX1 (sprot)

An ATP-dependent RNA helicase DDX1 that is encoded in the genome of human.


KCNK9_RAT Potassium channel subfamily K member 9 (sprot)

A potassium channel subfamily K member 9 that is encoded in the genome of rat.


DCTP1_HUMAN dCTP pyrophosphatase 1 (sprot)

A dCTP pyrophosphatase 1 that is encoded in the genome of human.


MTOR_MOUSE Serine/threonine-protein kinase mTOR (sprot)

A serine/threonine-protein kinase mTOR that is encoded in the genome of mouse.


CDK12_HUMAN Cyclin-dependent kinase 12 (sprot)

A cyclin-dependent kinase 12 that is encoded in the genome of human.


TRPC4_MOUSE Short transient receptor potential channel 4 (sprot)

A short transient receptor potential cation channel TRPC4 that is encoded in the genome of mouse.


TRPC5_MOUSE Short transient receptor potential channel 5 (sprot)

A short transient receptor potential channel 5 that is encoded in the genome of mouse.


SEPT9_HUMAN Septin-9 (sprot)

A septin-9 that is encoded in the genome of human.


P2RX7_MOUSE P2X purinoceptor 7 (sprot)

A P2X purinoceptor 7 that is encoded in the genome of mouse.


KPYR_HUMAN Pyruvate kinase PKLR (sprot)

A pyruvate kinase PKLR that is encoded in the genome of human.


KPYM_HUMAN Pyruvate kinase PKM (sprot)

A pyruvate kinase PKM that is encoded in the genome of human.


LAG3_HUMAN Lymphocyte activation gene 3 protein (sprot)

A lymphocyte activation gene 3 protein that is encoded in the genome of human.


GIPR_HUMAN Gastric inhibitory polypeptide receptor (sprot)

A gastric inhibitory polypeptide receptor that is encoded in the genome of human.


B5DFE2_RAT Histone-lysine N-methyltransferase EZH2 (trembl)


Novobiocin

An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)

A coumarin-derived antibiotic obtained from Streptomyces niveus.


PARE_STAAU DNA topoisomerase 4 subunit B (sprot)

A protein that is a translation product of the parE gene in Staphylococcus aureus.


GRK5_HUMAN G protein-coupled receptor kinase 5 (sprot)

A G protein-coupled receptor kinase 5 that is encoded in the genome of human.


8ODP_HUMAN Oxidized purine nucleoside triphosphate hydrolase (sprot)

An oxidized purine nucleoside triphosphate hydrolase that is encoded in the genome of human.


TRBP2_HUMAN RISC-loading complex subunit TARBP2 (sprot)

A RISC-loading complex subunit TARBP2 that is encoded in the genome of human.


SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (sprot)

An NAD-dependent protein deacylase sirtuin-6 that is encoded in the genome of human.


ACMSD_HUMAN 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (sprot)

A 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase that is encoded in the genome of human.


NR4A3_HUMAN Nuclear receptor subfamily 4 group A member 3 (sprot)

A nuclear receptor subfamily 4 group A member 3 that is encoded in the genome of human.


Sulfisomidine

A sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.


AGO2_HUMAN Protein argonaute-2 (sprot)

A protein argonaute-2 that is encoded in the genome of human.


Q8I5G6_PLAF7 Isoleucine--tRNA ligase, putative (trembl)


Dichlorvos

An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.


ACES_ANOGA Acetylcholinesterase (sprot)

An insect-type acetylcholinesterase that is a translation product of the Ace gene in Anopheles gambiae.


HS90B_HUMAN Heat shock protein HSP 90-beta (sprot)

A heat shock protein HSP 90-beta that is encoded in the genome of human.


IL31R_HUMAN Interleukin-31 receptor subunit alpha (sprot)

An interleukin-31 receptor A that is encoded in the genome of human.


Q6V2E7_HRSV Fusion glycoprotein F0 (trembl)


A0A8C0QLS2_CANLF Glucocorticoid receptor (trembl)


BAD_HUMAN Bcl2-associated agonist of cell death (sprot)

A Bcl2-associated agonist of cell death that is encoded in the genome of human.


Gossypol

A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.


MLP3B_HUMAN Microtubule-associated proteins 1A/1B light chain 3B (sprot)

A microtubule-associated proteins 1A/1B light chain 3B that is encoded in the genome of human.