MLP3A_HUMAN Microtubule-associated proteins 1A/1B light chain 3A (sprot)

A microtubule-associated proteins 1A/1B light chain 3A that is encoded in the genome of human.


CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain (sprot)

A CD3 epsilon that is encoded in the genome of human.


MPC2_HUMAN Mitochondrial pyruvate carrier 2 (sprot)

A brain protein 44 that is encoded in the genome of human.


S36A1_HUMAN Proton-coupled amino acid transporter 1 (sprot)

A proton-coupled amino acid transporter 1 that is encoded in the genome of human.


TRPV4_HUMAN Transient receptor potential cation channel subfamily V member 4 (sprot)

A transient receptor potential cation channel TRPV4 that is encoded in the genome of human.


R1AB_SARS2 Replicase polyprotein 1ab (sprot)


Baicalin

has iron chelating activity; chemical component of Chinese medicinal herb Huang-chin (Scutellaria baicalensis); do not confuse with baicalein

The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis.


EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (sprot)

A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of human.


EZH1_HUMAN Histone-lysine N-methyltransferase EZH1 (sprot)

A histone-lysine N-methyltransferase EZH1 that is encoded in the genome of human.


CALCB_HUMAN Calcitonin gene-related peptide 2 (sprot)

A calcitonin gene-related peptide 2 that is encoded in the genome of human.


NTCP2_HUMAN Ileal sodium/bile acid cotransporter (sprot)

An ileal sodium/bile acid cotransporter that is encoded in the genome of human.


ERR1_MOUSE Steroid hormone receptor ERR1 (sprot)

A steroid hormone receptor ERR1 that is encoded in the genome of mouse.


SC5A1_MOUSE Sodium/glucose cotransporter 1 (sprot)

A sodium/glucose cotransporter 1 that is encoded in the genome of mouse.


SC5A1_RAT Sodium/glucose cotransporter 1 (sprot)

A sodium/glucose cotransporter 1 that is encoded in the genome of rat.


SL9A3_RAT Sodium/hydrogen exchanger 3 (sprot)

A sodium/hydrogen exchanger 3 that is encoded in the genome of rat.


PK3CG_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (sprot)

A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform that is encoded in the genome of mouse.


DGLA_MOUSE Diacylglycerol lipase-alpha (sprot)

A diacylglycerol lipase-alpha that is encoded in the genome of mouse.


ADRB1_MOUSE Beta-1 adrenergic receptor (sprot)

A beta-1 adrenergic receptor that is encoded in the genome of mouse.


Levisoprenaline

An optically active phenylethanolamine compound having an isopropyl substituent attached to the nitrogen atom.


Q5YLN7_CANLF Voltage-gated sodium channel Nav1.5 cardiac isoform (Fragment) (trembl)


CRTN_STAAE 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) (sprot)


B2V8E3_SULSY Carbonic anhydrase (trembl)


Ethoxzolamide

A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.

A sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic.


BLAN1_KLEPN Metallo-beta-lactamase type 2 (sprot)

A protein that is a translation product of any of the plasmid-encoded copies of the blaNDM-1 gene in Klebsiella pneumoniae.


PRKX_HUMAN cAMP-dependent protein kinase catalytic subunit PRKX (sprot)

A serine/threonine-protein kinase PRKX that is encoded in the genome of human.


ST32B_HUMAN Serine/threonine-protein kinase 32B (sprot)

A serine/threonine-protein kinase 32B that is encoded in the genome of human.


CP26B_HUMAN Cytochrome P450 26B1 (sprot)

A cytochrome P450 26B1 that is encoded in the genome of human.


HPPK_ECOLI 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (sprot)

A 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase that is encoded in the genome of Escherichia coli K-12.


CALM1_HUMAN Calmodulin-1 (sprot)

A calmodulin (human) that is a translation product of the CALM1 gene.


CALM2_HUMAN Calmodulin-2 (sprot)

A calmodulin (human) that is a translation product of the CALM2 gene.


CALM3_HUMAN Calmodulin-3 (sprot)

A calmodulin (human) that is a translation product of the CALM3 gene.


CALCA_HUMAN Calcitonin gene-related peptide 1 (sprot)


IL3RA_HUMAN Interleukin-3 receptor subunit alpha (sprot)

An interleukin-3 receptor class 2 alpha chain that is encoded in the genome of human.


IL3RB_HUMAN Cytokine receptor common subunit beta (sprot)

A cytokine receptor common subunit beta that is encoded in the genome of human.


GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 (sprot)

A gamma-aminobutyric acid receptor subunit alpha-6 that is encoded in the genome of human.


GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3 (sprot)

A gamma-aminobutyric acid receptor subunit beta-3 that is encoded in the genome of human.


GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta (sprot)

A gamma-aminobutyric acid receptor subunit delta that is encoded in the genome of human.


XPO1_HUMAN Exportin-1 (sprot)

An exportin-1 that is encoded in the genome of human.


SNP25_HUMAN Synaptosomal-associated protein 25 (sprot)

A synaptosomal-associated protein 25 that is encoded in the genome of human.


GDF8_HUMAN Growth/differentiation factor 8 (sprot)

A growth/differentiation factor 8 that is encoded in the genome of human.


LYAM3_HUMAN P-selectin (sprot)

A P-selectin that is encoded in the genome of human.


EGLN2_HUMAN Prolyl hydroxylase EGLN2 (sprot)

A prolyl hydroxylase EGLN2 that is encoded in the genome of human.


EGLN3_HUMAN Prolyl hydroxylase EGLN3 (sprot)

A prolyl hydroxylase EGLN3 that is encoded in the genome of human.


D0CCM7_ACIB2 Peptidoglycan D,D-transpeptidase FtsI (trembl)


APOC3_HUMAN Apolipoprotein C-III (sprot)

An apolipoprotein C-III that is encoded in the genome of human.


DMD_HUMAN Dystrophin (sprot)

A dystrophin that is encoded in the genome of human.


TTHY_HUMAN Transthyretin (sprot)

A transthyretin that is encoded in the genome of human.


KCNC4_RAT Potassium voltage-gated channel subfamily C member 4 (sprot)

A voltage-gated potassium channel KCNC4 that is encoded in the genome of rat.


TRPA1_MOUSE Transient receptor potential cation channel subfamily A member 1 (sprot)

A transient receptor potential cation channel TRPA1 that is encoded in the genome of mouse.


CAC1H_RAT Voltage-dependent T-type calcium channel subunit alpha-1H (sprot)

A voltage-dependent T-type calcium channel subunit alpha-1H that is encoded in the genome of rat.


P2RX3_RAT P2X purinoceptor 3 (sprot)

A P2X purinoceptor 3 that is encoded in the genome of rat.


ADRB3_MOUSE Beta-3 adrenergic receptor (sprot)

A beta-3 adrenergic receptor that is encoded in the genome of mouse.


5HT1B_MOUSE 5-hydroxytryptamine receptor 1B (sprot)

A 5-hydroxytryptamine receptor 1B that is encoded in the genome of mouse.


KCND3_RAT Potassium voltage-gated channel subfamily D member 3 (sprot)

A voltage-gated potassium channel KCND3 that is encoded in the genome of rat.


CASR_RAT Extracellular calcium-sensing receptor (sprot)

An extracellular calcium-sensing receptor that is encoded in the genome of rat.


FKB1A_RAT Peptidyl-prolyl cis-trans isomerase FKBP1A (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP1A that is encoded in the genome of rat.


KCNA4_RAT Potassium voltage-gated channel subfamily A member 4 (sprot)

A voltage-gated potassium channel alpha subunit KCNA4 that is encoded in the genome of rat.


TRPV4_MOUSE Transient receptor potential cation channel subfamily V member 4 (sprot)

A transient receptor potential cation channel TRPV4 that is encoded in the genome of mouse.


TRPM7_MOUSE Transient receptor potential cation channel subfamily M member 7 (sprot)

A transient receptor potential cation channel subfamily M member 7 that is encoded in the genome of mouse.


5HT4R_MOUSE 5-hydroxytryptamine receptor 4 (sprot)

A 5-hydroxytryptamine receptor 4 that is encoded in the genome of mouse.


KCNT1_RAT Potassium channel subfamily T member 1 (sprot)

A potassium channel subfamily T member 1 that is encoded in the genome of rat.


SV2A_RAT Synaptic vesicle glycoprotein 2A (sprot)

A synaptic vesicle glycoprotein 2A that is encoded in the genome of rat.


TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 (sprot)

A transient receptor potential cation channel TRPV2 that is encoded in the genome of rat.


TRPV1_MOUSE Transient receptor potential cation channel subfamily V member 1 (sprot)

A transient receptor potential cation channel TRPV1 that is encoded in the genome of mouse.


KCNJ5_MOUSE G protein-activated inward rectifier potassium channel 4 (sprot)

A G protein-activated inward rectifier potassium channel 4 that is encoded in the genome of mouse.


P2RX4_MOUSE P2X purinoceptor 4 (sprot)

A P2X purinoceptor 4 that is encoded in the genome of mouse.


NR2C2_HUMAN Nuclear receptor subfamily 2 group C member 2 (sprot)

A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human.


TPC1_HUMAN Two pore channel protein 1 (sprot)

A two pore channel protein 1 that is encoded in the genome of human.


ADRB3_RAT Beta-3 adrenergic receptor (sprot)

A beta-3 adrenergic receptor that is encoded in the genome of rat.


KCNJ6_MOUSE G protein-activated inward rectifier potassium channel 2 (sprot)

A G protein-activated inward rectifier potassium channel 2 that is encoded in the genome of mouse.


Uridine 5'-triphosphate

Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.

A pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase.


P2RY4_RAT P2Y purinoceptor 4 (sprot)

A P2Y purinoceptor 4 that is encoded in the genome of rat.


HCN4_MOUSE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (sprot)

A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of mouse.


GUC2C_RAT Guanylyl cyclase C (sprot)

A guanylyl cyclase C that is encoded in the genome of rat.


S6A19_RAT Sodium-dependent neutral amino acid transporter B(0)AT1 (sprot)

A sodium-dependent neutral amino acid transporter B(0)AT1 that is encoded in the genome of rat.


SSR2_RAT Somatostatin receptor type 2 (sprot)

A somatostatin receptor type 2 that is encoded in the genome of rat.


KCNA1_MOUSE Potassium voltage-gated channel subfamily A member 1 (sprot)

A voltage-gated potassium channel subunit KCNA1 that is encoded in the genome of mouse.


S47A2_MOUSE Multidrug and toxin extrusion protein 2 (sprot)

A multidrug resistance protein MdtK that is encoded in the genome of mouse.


SO2B1_HUMAN Solute carrier organic anion transporter family member 2B1 (sprot)

A solute carrier organic anion transporter family member 2B1 that is encoded in the genome of human.


SL9A5_HUMAN Sodium/hydrogen exchanger 5 (sprot)

A sodium/hydrogen exchanger 5 that is encoded in the genome of human.


PD2R2_MOUSE Prostaglandin D2 receptor 2 (sprot)

A prostaglandin D2 receptor DP2 that is encoded in the genome of mouse.


PE2R3_RAT Prostaglandin E2 receptor EP3 subtype (sprot)

A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of rat.


Gardrin

A synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has been shown to be efficient and safe in the treatment of gastroduodenal ulcers.


CAC1E_RAT Voltage-dependent R-type calcium channel subunit alpha-1E (sprot)

A voltage-dependent R-type calcium channel subunit alpha-1E that is encoded in the genome of rat.


SCN5A_RAT Sodium channel protein type 5 subunit alpha (sprot)

A sodium channel protein type 5 subunit alpha that is encoded in the genome of rat.


GP139_HUMAN Probable G-protein coupled receptor 139 (sprot)

A probable G-protein coupled receptor 139 that is encoded in the genome of human.


CAC1A_RAT Voltage-dependent P/Q-type calcium channel subunit alpha-1A (sprot)

A voltage-dependent P/Q-type calcium channel subunit alpha-1A that is encoded in the genome of rat.


PUR2_MOUSE Trifunctional purine biosynthetic protein adenosine-3 (sprot)

A trifunctional purine biosynthetic protein adenosine-3 that is encoded in the genome of mouse.


SSR3_RAT Somatostatin receptor type 3 (sprot)

A somatostatin receptor type 3 that is encoded in the genome of rat.


PE2R1_RAT Prostaglandin E2 receptor EP1 subtype (sprot)

A prostaglandin E2 receptor EP1 subtype that is encoded in the genome of rat.


P2RX4_RAT P2X purinoceptor 4 (sprot)

A P2X purinoceptor 4 that is encoded in the genome of rat.


P2RX5_RAT P2X purinoceptor 5 (sprot)

A P2X purinoceptor 5 that is encoded in the genome of rat.


CAC1C_MOUSE Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of mouse.


CD22_HUMAN B-cell receptor CD22 (sprot)

A B-cell receptor CD22 that is encoded in the genome of human.


IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial (sprot)

An isocitrate dehydrogenase [NADP], mitochondrial that is encoded in the genome of human.


TNR16_HUMAN Tumor necrosis factor receptor superfamily member 16 (sprot)

A tumor necrosis factor receptor superfamily member 16 that is encoded in the genome of human.


PARP4_HUMAN Protein mono-ADP-ribosyltransferase PARP4 (sprot)

A protein mono-ADP-ribosyltransferase PARP4 that is encoded in the genome of human.


PAR10_HUMAN Protein mono-ADP-ribosyltransferase PARP10 (sprot)

A protein mono-ADP-ribosyltransferase PARP10 that is encoded in the genome of human.


PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (sprot)

A protein mono-ADP-ribosyltransferase PARP14 that is encoded in the genome of human.


PAR15_HUMAN Protein mono-ADP-ribosyltransferase PARP15 (sprot)

A protein mono-ADP-ribosyltransferase PARP15 that is encoded in the genome of human.


SCN9A_MOUSE Sodium channel protein type 9 subunit alpha (sprot)

A sodium channel protein type 9 subunit alpha that is encoded in the genome of mouse.


NRAM_I77AB Neuraminidase (sprot)

A neuraminidase subtype N1 (Influenza A virus) that is encoded in the genome of the H1N1 strain A/USSR/90/1977.


a nitrone benzene bissulfonate in development for stroke; has neuroprotective activity


Q39829_SOYBN Lipoxygenase (Fragment) (trembl)


S6A11_MOUSE Sodium- and chloride-dependent GABA transporter 3 (sprot)

A sodium- and chloride-dependent GABA transporter 3 that is encoded in the genome of mouse.


INSR_RAT Insulin receptor (sprot)

An insulin receptor that is encoded in the genome of rat.


ARAF_HUMAN Serine/threonine-protein kinase A-Raf (sprot)

A serine/threonine-protein kinase A-Raf that is encoded in the genome of human.


DNPEP_PLAF7 Aspartyl aminopeptidase (sprot)


MURI_LIMFE Glutamate racemase (sprot)

A protein that is a translation product of the murI gene in Limosilactobacillus fermentum.


HEXA_HUMAN Beta-hexosaminidase subunit alpha (sprot)

A beta-hexosaminidase subunit alpha that is encoded in the genome of human.


ABCBB_RAT Bile salt export pump (sprot)

A bile salt export pump that is encoded in the genome of rat.


Glafenine

An anthranilic acid derivative with analgesic properties used for the relief of all types of pain.

A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.


S6A13_RAT Sodium- and chloride-dependent GABA transporter 2 (sprot)

A sodium- and chloride-dependent GABA transporter 2 that is encoded in the genome of rat.


S6A13_MOUSE Sodium- and chloride-dependent GABA transporter 2 (sprot)

A sodium- and chloride-dependent GABA transporter 2 that is encoded in the genome of mouse.


Q5TU56_ANOGA Carbonic anhydrase (trembl)


CP27B_MOUSE 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (sprot)

A 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial that is encoded in the genome of mouse.


GRM8_RAT Metabotropic glutamate receptor 8 (sprot)

A metabotropic glutamate receptor 8 that is encoded in the genome of rat.


LSHR_RAT Lutropin-choriogonadotropic hormone receptor (sprot)

A lutropin-choriogonadotropic hormone receptor that is encoded in the genome of rat.


P2Y12_RAT P2Y purinoceptor 12 (sprot)

A P2Y purinoceptor 12 that is encoded in the genome of rat.


Q8MI13_BOVIN 5-hydroxytryptamine 1D receptor (Fragment) (trembl)


DYR1A_RAT Dual specificity tyrosine-phosphorylation-regulated kinase 1A (sprot)

A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of rat.


Bergapten

A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.

A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.


GRM8_MOUSE Metabotropic glutamate receptor 8 (sprot)

A metabotropic glutamate receptor 8 that is encoded in the genome of mouse.


Tannic Acid

Any of a group of astringent polyphenolic vegetable principles or compounds, chiefly complex glucosides of catechol and pyrogallol.


LTC4S_CAVPO Leukotriene C4 synthase (sprot)


A4_HUMAN Amyloid-beta precursor protein (sprot)

An amyloid-beta precursor protein that is encoded in the genome of human.


Amodiaquine

A 4-aminoquinoline compound with anti-inflammatory properties.

A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.


SDIS_PSEPU Steroid Delta-isomerase (sprot)


GLD1_CAEEL Female germline-specific tumor suppressor gld-1 (sprot)

A protein that is a translation product of the gld-1 gene in worm.


A0A0K1CY61_9HEPC Genome polyprotein (Fragment) (trembl)


RCE1_YEAST CAAX prenyl protease 2 (sprot)

A protein that is a translation product of the RCE1 gene in yeast.


Colforsin daropate

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.

A carboxylic ester resuting from the formal condensation of the carboxy group of N,N-dimethyl-beta-alanine with the 6-hydroxy group of forskolin. It is an adenylate cyclase activator.


ADCY1_BOVIN Adenylate cyclase type 1 (sprot)

An adenylate cyclase type 1 that is encoded in the genome of cow.


HMDH_PIG 3-hydroxy-3-methylglutaryl-coenzyme A reductase (sprot)


Dimetacrine

minor descriptor (75-84); on-line & Index Medicus search ACRIDINES (75-84); RN given refers to parent cpd without isomeric designation


Q7KQK5_PLAF7 Apical membrane antigen 1 (trembl)


C11B1_RAT Cytochrome P450 11B1, mitochondrial (sprot)

A protein that is a translation product of the Cyp11b1 gene in rat.


Triclocarban

bacteriostat; antiseptic in soaps & other cleansing solns; germicide; structure

A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.


HYEP_HUMAN Epoxide hydrolase 1 (sprot)

An epoxide hydrolase 1 that is encoded in the genome of human.


AMYP_RAT Pancreatic alpha-amylase (sprot)

A protein that is a translation product of the Amy2 gene in rat.


AT1A1_RAT Sodium/potassium-transporting ATPase subunit alpha-1 (sprot)

A sodium/potassium-transporting ATPase subunit alpha-1 that is encoded in the genome of rat.


PROTOPORPHYRIN

A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.


POS1_CAEEL RNA-binding protein pos-1 (sprot)


Methysergide

An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.


GRM5_RAT Metabotropic glutamate receptor 5 (sprot)

A metabotropic glutamate receptor 5 that is encoded in the genome of rat.


Q8Z9J9_SALTI Dihydrofolate reductase (trembl)


Brodimoprim

An aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group.


HYEP_MOUSE Epoxide hydrolase 1 (sprot)

An epoxide hydrolase 1 that is encoded in the genome of mouse.


GRM2_RAT Metabotropic glutamate receptor 2 (sprot)

A metabotropic glutamate receptor 2 that is encoded in the genome of rat.


AT2A1_RAT Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (sprot)

A protein that is a translation product of the Atp2a1 gene in rat.


ELNE_MOUSE Neutrophil elastase (sprot)

A neutrophil elastase that is encoded in the genome of mouse.


GLF_MYCTU UDP-galactopyranose mutase (sprot)

A UDP-galactopyranose mutase that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


Q91ZY3_CAVPO Histamine H4 receptor (trembl)


Q76353_9HIV1 Integrase (Fragment) (trembl)


ICAM1_HUMAN Intercellular adhesion molecule 1 (sprot)

An intercellular adhesion molecule 1 that is encoded in the genome of human.


3MG_HUMAN DNA-3-methyladenine glycosylase (sprot)

A DNA-3-methyladenine glycosylase that is encoded in the genome of human.


HS71A_HUMAN Heat shock 70 kDa protein 1A (sprot)

A heat shock 70 kDa protein 1A that is encoded in the genome of human.


DNPH1_HUMAN 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (sprot)

A 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 that is encoded in the genome of human.


EED_HUMAN Polycomb protein EED (sprot)

A polycomb protein EED that is encoded in the genome of human.


S6A15_HUMAN Sodium-dependent neutral amino acid transporter B(0)AT2 (sprot)

A sodium-dependent neutral amino acid transporter B(0)AT2 that is encoded in the genome of human.


UBP1_HUMAN Ubiquitin carboxyl-terminal hydrolase 1 (sprot)

A ubiquitin carboxyl-terminal hydrolase 1 that is encoded in the genome of human.


PRTN3_HUMAN Myeloblastin (sprot)

A myeloblastin that is encoded in the genome of human.


NOD2_HUMAN Nucleotide-binding oligomerization domain-containing protein 2 (sprot)

A nucleotide-binding oligomerization domain-containing protein 2 that is encoded in the genome of human.


CD2_HUMAN T-cell surface antigen CD2 (sprot)

A CD2 molecule that is encoded in the genome of human.


IL1RA_HUMAN Interleukin-1 receptor antagonist protein (sprot)

An interleukin-1 receptor antagonist protein that is encoded in the genome of human.


SLAF7_HUMAN SLAM family member 7 (sprot)

A SLAM family member 7 that is encoded in the genome of human.


SAE1_HUMAN SUMO-activating enzyme subunit 1 (sprot)

A SUMO-activating enzyme subunit 1 that is encoded in the genome of human.


SAE2_HUMAN SUMO-activating enzyme subunit 2 (sprot)

A SUMO-activating enzyme subunit 2 that is encoded in the genome of human.


CCND1_HUMAN G1/S-specific cyclin-D1 (sprot)

A G1/S-specific cyclin-D1 that is encoded in the genome of human.


CDK6_HUMAN Cyclin-dependent kinase 6 (sprot)

A cyclin-dependent kinase 6 that is encoded in the genome of human.


HSP7C_HUMAN Heat shock cognate 71 kDa protein (sprot)

A heat shock cognate 71 kDa protein that is encoded in the genome of human.


FACE2_HUMAN CAAX prenyl protease 2 (sprot)

A CAAX prenyl protease 2 that is encoded in the genome of human.


CASP7_HUMAN Caspase-7 (sprot)

A caspase-7 that is encoded in the genome of human.


S6A12_HUMAN Sodium- and chloride-dependent betaine transporter (sprot)

A sodium- and chloride-dependent betaine transporter that is encoded in the genome of human.


PDK1_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (sprot)

A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial that is encoded in the genome of human.


PDK3_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (sprot)

A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial that is encoded in the genome of human.


PDK4_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (sprot)

A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial that is encoded in the genome of human.


GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4 (sprot)

A gamma-aminobutyric acid receptor subunit alpha-4 that is encoded in the genome of human.


Methaqualone

A quinazoline derivative with hypnotic and sedative properties. It has been withdrawn from the market in many countries because of problems with abuse. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

A member of the class of quinazolines that is quinazolin-4-one substituted at positions 2 and 3 by methyl and  o-tolyl groups respectively. A depressant that increases the activity of the GABA receptors in the brain and nervous system, it is used as a sedative and hypnotic medication. It became popular as a recreational drug and club drug in the late 1960s and 1970s.


GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2 (sprot)

A gamma-aminobutyric acid receptor subunit beta-2 that is encoded in the genome of human.


PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (sprot)

A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of human.


SC6A8_RAT Sodium- and chloride-dependent creatine transporter 1 (sprot)

A sodium- and chloride-dependent creatine transporter 1 that is encoded in the genome of rat.


Deanol

An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood.

A  tertiary amine that is ethanolamine having two N-methyl substituents.


DOPO_BOVIN Dopamine beta-hydroxylase (sprot)

A dopamine beta-hydroxylase that is encoded in the genome of cow.


OXDA_PIG D-amino-acid oxidase (sprot)

A D-amino-acid oxidase that is encoded in the genome of pig.


Imidacloprid

Systemic contact insecticide exhibiting low mammalian toxicity. This neonicotinoid insecticide acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system

The E-isomer of imidacloprid.


H6TY12_PERAM Nicotinic acetylcholine receptor alpha8 subunit (trembl)


PUNA_MYCTU Purine nucleoside phosphorylase (sprot)

A purine nucleoside phosphorylase that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


Q8VH27_CAVPO Muscarinic acetylcholine receptor (Fragment) (trembl)


Perhexiline

2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.


CPT2_RAT Carnitine O-palmitoyltransferase 2, mitochondrial (sprot)

A carnitine O-palmitoyltransferase 2, mitochondrial that is encoded in the genome of rat.


Menadione

A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.


DUS1_MOUSE Dual specificity protein phosphatase 1 (sprot)

A dual specificity protein phosphatase 1 that is encoded in the genome of mouse.


SCNAA_RAT Sodium channel protein type 10 subunit alpha (sprot)

A sodium channel protein type 10 subunit alpha that is encoded in the genome of rat.


AA2AR_CAVPO Adenosine receptor A2a (sprot)

An adenosine receptor A2a that is encoded in the genome of guinea pig.


Enprofylline

Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.


DCOR_RAT Ornithine decarboxylase (sprot)

An ornithine decarboxylase that is encoded in the genome of rat.


VM1B1_BOTAS Snake venom metalloproteinase BaP1 (sprot)


ADRB2_MESAU Beta-2 adrenergic receptor (sprot)

A protein that is a translation product of the ADRB2 gene in Mesocricetus auratus.


Q9W6Q1_9SALA Sodium/hydrogen exchanger (trembl)


An adenosylhomocysteinase that is encoded in the genome of mouse.


KAP2_BOVIN cAMP-dependent protein kinase type II-alpha regulatory subunit (sprot)

A cAMP-dependent protein kinase type II-alpha regulatory subunit that is encoded in the genome of cow.


KAPCA_BOVIN cAMP-dependent protein kinase catalytic subunit alpha (sprot)

A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of cow.


KAPCB_BOVIN cAMP-dependent protein kinase catalytic subunit beta (sprot)


KAP3_BOVIN cAMP-dependent protein kinase type II-beta regulatory subunit (sprot)

A cAMP-dependent protein kinase type II-beta regulatory subunit that is encoded in the genome of cow.


Fenticlor

An aryl sulfide having two 5-chloro-2-hydroxyphenyl groups attached to sulfur; an antiinfective drug mostly used in veterinary medicine.


UNG_VACCW Uracil-DNA glycosylase (sprot)


DYR1_ECOLX Dihydrofolate reductase type 1 (sprot)

A protein that is a translation product of any of the plasmid-encoded copies of the dhfrI gene in Escherichia coli.


ERG1_RAT Squalene monooxygenase (sprot)

A squalene monooxygenase that is encoded in the genome of rat.


DDLB_ECOLI D-alanine--D-alanine ligase B (sprot)

A D-alanine--D-alanine ligase B that is encoded in the genome of Escherichia coli K-12.


GSHR_YEAST Glutathione reductase (sprot)

A glutathione reductase, mitochondrial that is encoded in the genome of yeast.


SC6A3_MACFA Sodium-dependent dopamine transporter (sprot)

A sodium-dependent dopamine transporter that is encoded in the genome of Macaca fascicularis.


LAT1_RAT Large neutral amino acids transporter small subunit 1 (sprot)

A large neutral amino acids transporter small subunit 1 that is encoded in the genome of rat.


NU1M_BOVIN NADH-ubiquinone oxidoreductase chain 1 (sprot)


AMPN_RAT Aminopeptidase N (sprot)

An aminopeptidase N that is encoded in the genome of rat.


KCNC1_RAT Potassium voltage-gated channel subfamily C member 1 (sprot)

A voltage-gated potassium channel KCNC1 that is encoded in the genome of rat.


Propamidine

A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.


COX1_SHEEP Cytochrome c oxidase subunit 1 (sprot)

A cytochrome c oxidase subunit 1 that is encoded in the genome of sheep.


MDTK_ECOLI Multidrug resistance protein MdtK (sprot)

A multidrug resistance protein MdtK that is encoded in the genome of Escherichia coli K-12.


KCND2_RAT Potassium voltage-gated channel subfamily D member 2 (sprot)

A protein that is a translation product of the Kcnd2 gene in rat.


A 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase that is encoded in the genome of guinea pig.


ACPS_BACSU Holo-[acyl-carrier-protein] synthase (sprot)


I23O1_MOUSE Indoleamine 2,3-dioxygenase 1 (sprot)

An indoleamine 2,3-dioxygenase 1 that is encoded in the genome of mouse.


PANE_ECOLI 2-dehydropantoate 2-reductase (sprot)

A 2-dehydropantoate 2-reductase that is encoded in the genome of Escherichia coli K-12.


P90584_PLAFA MO15-related protein kinase Pfmrk (trembl)


VE2_HPV16 Regulatory protein E2 (sprot)

A protein that is a translation product of the E2 gene in Human papillomavirus type 16.


NTR2_RAT Neurotensin receptor type 2 (sprot)

A neurotensin receptor type 2 that is encoded in the genome of rat.


TOP1_MOUSE DNA topoisomerase 1 (sprot)

A type 1B DNA topoisomerase 1 that is encoded in the genome of mouse.


E2QDN0_ECOLX Thymidylate synthase (trembl)


IL5_MOUSE Interleukin-5 (sprot)

An interleukin-5 that is encoded in the genome of mouse.


DYR_ENTFC Dihydrofolate reductase (sprot)


PDE2A_BOVIN cGMP-dependent 3',5'-cyclic phosphodiesterase (sprot)


CCR5_MACMU C-C chemokine receptor type 5 (sprot)


CP11A_RAT Cholesterol side-chain cleavage enzyme, mitochondrial (sprot)

A cytochrome P450 11A1, mitochondrial that is encoded in the genome of rat.


CP24A_RAT 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (sprot)

A 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial that is encoded in the genome of rat.


CP17A_RAT Steroid 17-alpha-hydroxylase/17,20 lyase (sprot)

A cytochrome P450 17A1 that is encoded in the genome of rat.


HDAC6_MOUSE Histone deacetylase 6 (sprot)

A histone deacetylase 6 that is encoded in the genome of mouse.


T2S1_STRCS Type II restriction enzyme ScaI (sprot)

A DNA restriction-modification endonuclease that is a translation product of the scaIR gene in Streptomyces caespitosus.


AMYP_PIG Pancreatic alpha-amylase (sprot)

A protein that is a translation product of the AMY2 gene in pig.


RORG_MOUSE Nuclear receptor ROR-gamma (sprot)

A nuclear receptor ROR-gamma that is encoded in the genome of mouse.


GLUCB_HAECO Glutamate-gated chloride channel subunit beta (sprot)


Q25634_ONCVO Glutamate-gated chloride channel (Fragment) (trembl)


VANX_ENTFC D-alanyl-D-alanine dipeptidase (sprot)

A protein that is a translation product of any of the plasmid-encoded copies of the vanX gene in Enterococcus faecium.


GGT1_RAT Glutathione hydrolase 1 proenzyme (sprot)

A protein that is a translation product of the Ggt1 gene in rat.


PPBI_BOVIN Intestinal-type alkaline phosphatase (sprot)


Q54A96_PLAFA Dihydroorotate dehydrogenase (quinone), mitochondrial (trembl)


KCNQ3_HUMAN Potassium voltage-gated channel subfamily KQT member 3 (sprot)

A voltage-gated potassium channel subunit KCNQ3 that is encoded in the genome of human.


KCNQ2_HUMAN Potassium voltage-gated channel subfamily KQT member 2 (sprot)

A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of human.


KCNH1_HUMAN Potassium voltage-gated channel subfamily H member 1 (sprot)

A voltage-gated potassium channel KCNH1 that is encoded in the genome of human.


KCNA2_HUMAN Potassium voltage-gated channel subfamily A member 2 (sprot)

A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of human.


KCNA6_HUMAN Potassium voltage-gated channel subfamily A member 6 (sprot)

A voltage-gated potassium channel subunit KCNA6 that is encoded in the genome of human.


KCNA3_HUMAN Potassium voltage-gated channel subfamily A member 3 (sprot)

A voltage-gated potassium channel subunit KCNA3 that is encoded in the genome of human.


KCNA4_HUMAN Potassium voltage-gated channel subfamily A member 4 (sprot)

A voltage-gated potassium channel alpha subunit KCNA4 that is encoded in the genome of human.


KCNA5_HUMAN Potassium voltage-gated channel subfamily A member 5 (sprot)

A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human.


KCNC1_HUMAN Potassium voltage-gated channel subfamily C member 1 (sprot)

A voltage-gated potassium channel KCNC1 that is encoded in the genome of human.


KCNQ1_HUMAN Potassium voltage-gated channel subfamily KQT member 1 (sprot)

A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of human.


KCNQ4_HUMAN Potassium voltage-gated channel subfamily KQT member 4 (sprot)

A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human.


KCNC4_HUMAN Potassium voltage-gated channel subfamily C member 4 (sprot)

A voltage-gated potassium channel KCNC4 that is encoded in the genome of human.


KCNA1_HUMAN Potassium voltage-gated channel subfamily A member 1 (sprot)

A voltage-gated potassium channel subunit KCNA1 that is encoded in the genome of human.


KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2 (sprot)

A voltage-gated potassium channel KCNH2 that is encoded in the genome of human.


KCNC3_HUMAN Potassium voltage-gated channel subfamily C member 3 (sprot)

A voltage-gated potassium channel KCNC3 that is encoded in the genome of human.


KCNB1_HUMAN Potassium voltage-gated channel subfamily B member 1 (sprot)

A voltage-gated potassium channel KCNB1 that is encoded in the genome of human.


KCA10_HUMAN Potassium voltage-gated channel subfamily A member 10 (sprot)

A voltage-gated potassium channel subunit KCNA10 that is encoded in the genome of human.


KCNV1_HUMAN Potassium voltage-gated channel subfamily V member 1 (sprot)

A voltage-gated potassium channel KCNV1 that is encoded in the genome of human.


KCNH5_HUMAN Potassium voltage-gated channel subfamily H member 5 (sprot)

A voltage-gated potassium channel KCNH5 that is encoded in the genome of human.


KCNG3_HUMAN Potassium voltage-gated channel subfamily G member 3 (sprot)

A voltage-gated potassium channel subfamily G member 3 that is encoded in the genome of human.


KCNG4_HUMAN Potassium voltage-gated channel subfamily G member 4 (sprot)

A voltage-gated potassium channel subfamily G member 4 that is encoded in the genome of human.


KCNV2_HUMAN Potassium voltage-gated channel subfamily V member 2 (sprot)

A voltage-gated potassium channel KCNV2 that is encoded in the genome of human.


KCNB2_HUMAN Potassium voltage-gated channel subfamily B member 2 (sprot)

A voltage-gated potassium channel KCNB2 that is encoded in the genome of human.


KCNS1_HUMAN Potassium voltage-gated channel subfamily S member 1 (sprot)

A voltage-gated potassium channel KCNS1 that is encoded in the genome of human.


KCNH8_HUMAN Potassium voltage-gated channel subfamily H member 8 (sprot)

A voltage-gated potassium channel KCNH8 that is encoded in the genome of human.


KCNC2_HUMAN Potassium voltage-gated channel subfamily C member 2 (sprot)

A voltage-gated potassium channel KCNC2 that is encoded in the genome of human.


KCNA7_HUMAN Potassium voltage-gated channel subfamily A member 7 (sprot)

A voltage-gated potassium channel subunit KCNA7 that is encoded in the genome of human.


KCNS3_HUMAN Potassium voltage-gated channel subfamily S member 3 (sprot)

A voltage-gated potassium channel KCNS3 that is encoded in the genome of human.


KCNH6_HUMAN Potassium voltage-gated channel subfamily H member 6 (sprot)

A voltage-gated potassium channel KCNH6 that is encoded in the genome of human.


KCNF1_HUMAN Potassium voltage-gated channel subfamily F member 1 (sprot)

A voltage-gated potassium channel KCNF1 that is encoded in the genome of human.


KCNQ5_HUMAN Potassium voltage-gated channel subfamily KQT member 5 (sprot)

A voltage-gated potassium channel subunit KCNQ5 that is encoded in the genome of human.


KCNH7_HUMAN Potassium voltage-gated channel subfamily H member 7 (sprot)

A voltage-gated potassium channel KCNH7 that is encoded in the genome of human.


KCND1_HUMAN Potassium voltage-gated channel subfamily D member 1 (sprot)

A voltage-gated potassium channel KCND1 that is encoded in the genome of human.


KCND2_HUMAN Potassium voltage-gated channel subfamily D member 2 (sprot)

A voltage-gated potassium channel KCND2 that is encoded in the genome of human.


KCNG1_HUMAN Potassium voltage-gated channel subfamily G member 1 (sprot)

A voltage-gated potassium channel KCNG1 that is encoded in the genome of human.


KCNG2_HUMAN Potassium voltage-gated channel subfamily G member 2 (sprot)

A voltage-gated potassium channel KCNG2 that is encoded in the genome of human.


KCND3_HUMAN Potassium voltage-gated channel subfamily D member 3 (sprot)

A voltage-gated potassium channel KCND3 that is encoded in the genome of human.


KCNH3_HUMAN Potassium voltage-gated channel subfamily H member 3 (sprot)

A voltage-gated potassium channel KCNH3 that is encoded in the genome of human.


KCNS2_HUMAN Potassium voltage-gated channel subfamily S member 2 (sprot)

A voltage-gated potassium channel KCNS2 that is encoded in the genome of human.


KCNH4_HUMAN Potassium voltage-gated channel subfamily H member 4 (sprot)

A voltage-gated potassium channel KCNH4 that is encoded in the genome of human.


SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (sprot)

An NAD-dependent deacetylase sirtuin-5 that is encoded in the genome of human.


Adenine

A purine base and a fundamental unit of ADENINE NUCLEOTIDES.

The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.


PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha (sprot)

A phosphatidylinositol 4-kinase alpha that is encoded in the genome of human.


P4K2B_HUMAN Phosphatidylinositol 4-kinase type 2-beta (sprot)

A phosphatidylinositol 4-kinase type 2-beta that is encoded in the genome of human.


P4K2A_HUMAN Phosphatidylinositol 4-kinase type 2-alpha (sprot)

A phosphatidylinositol 4-kinase type 2-alpha that is encoded in the genome of human.


PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (sprot)

A phosphatidylinositol 4-kinase beta that is encoded in the genome of human.


ADRB1_HUMAN Beta-1 adrenergic receptor (sprot)

A beta-1 adrenergic receptor that is encoded in the genome of human.


ADA2A_HUMAN Alpha-2A adrenergic receptor (sprot)

An alpha-2A adrenergic receptor that is encoded in the genome of human.


ADRB3_HUMAN Beta-3 adrenergic receptor (sprot)

A beta-3 adrenergic receptor that is encoded in the genome of human.


ADA2B_HUMAN Alpha-2B adrenergic receptor (sprot)

An alpha-2B adrenergic receptor that is encoded in the genome of human.


ADA2C_HUMAN Alpha-2C adrenergic receptor (sprot)

An alpha-2C adrenergic receptor that is encoded in the genome of human.


ADA1D_HUMAN Alpha-1D adrenergic receptor (sprot)

An alpha-1D adrenergic receptor that is encoded in the genome of human.


ADA1A_HUMAN Alpha-1A adrenergic receptor (sprot)

An alpha-1A adrenergic receptor that is encoded in the genome of human.


ADA1B_HUMAN Alpha-1B adrenergic receptor (sprot)

An alpha-1B adrenergic receptor that is encoded in the genome of human.


CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G (sprot)

A voltage-dependent T-type calcium channel subunit alpha-1G that is encoded in the genome of human.


CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (sprot)

A voltage-dependent T-type calcium channel subunit alpha-1H that is encoded in the genome of human.


CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I (sprot)

A voltage-dependent T-type calcium channel subunit alpha-1I that is encoded in the genome of human.


UCHL3_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L3 (sprot)

A ubiquitin carboxyl-terminal hydrolase isozyme L3 that is encoded in the genome of human.


AA2AR_HUMAN Adenosine receptor A2a (sprot)

An adenosine receptor A2a that is encoded in the genome of human.


AA2BR_HUMAN Adenosine receptor A2b (sprot)

An adenosine receptor A2b that is encoded in the genome of human.


GUAD_HUMAN Guanine deaminase (sprot)

A guanine deaminase that is encoded in the genome of human.


SCN1A_HUMAN Sodium channel protein type 1 subunit alpha (sprot)

A sodium channel protein type 1 subunit alpha that is encoded in the genome of human.


SCN4A_HUMAN Sodium channel protein type 4 subunit alpha (sprot)

A sodium channel protein type 4 subunit alpha that is encoded in the genome of human.


SCN7A_HUMAN Sodium channel protein type 7 subunit alpha (sprot)

A sodium channel protein type 7 subunit alpha that is encoded in the genome of human.


SCN5A_HUMAN Sodium channel protein type 5 subunit alpha (sprot)

A sodium channel protein type 5 subunit alpha that is encoded in the genome of human.


SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (sprot)

A sodium channel protein type 9 subunit alpha that is encoded in the genome of human.


SCN2A_HUMAN Sodium channel protein type 2 subunit alpha (sprot)

A sodium channel protein type 2 subunit alpha that is encoded in the genome of human.


SCN3A_HUMAN Sodium channel protein type 3 subunit alpha (sprot)

A sodium channel protein type 3 subunit alpha that is encoded in the genome of human.


SCNBA_HUMAN Sodium channel protein type 11 subunit alpha (sprot)

A sodium channel protein type 11 subunit alpha that is encoded in the genome of human.


SCN8A_HUMAN Sodium channel protein type 8 subunit alpha (sprot)

A sodium channel protein type 8 subunit alpha that is encoded in the genome of human.


SCNAA_HUMAN Sodium channel protein type 10 subunit alpha (sprot)

A sodium channel protein type 10 subunit alpha that is encoded in the genome of human.


LPH_HUMAN Lactase/phlorizin hydrolase (sprot)

A lactase/phlorizin hydrolase that is encoded in the genome of human.


CAH3_BOVIN Carbonic anhydrase 3 (sprot)

A carbonic anhydrase 3 that is encoded in the genome of cow.


ADCY5_RAT Adenylate cyclase type 5 (sprot)

An adenylate cyclase type 5 that is encoded in the genome of rat.


G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase (sprot)

A glyceraldehyde-3-phosphate dehydrogenase that is encoded in the genome of human.


LMBL3_HUMAN Lethal(3)malignant brain tumor-like protein 3 (sprot)

A lethal(3)malignant brain tumor-like protein 3 that is encoded in the genome of human.


SAT1_HUMAN Diamine acetyltransferase 1 (sprot)

A diamine acetyltransferase 1 that is encoded in the genome of human.


Q8WS26_TRYCR Farnesyl diphosphate synthase (trembl)


Q81R22_BACAN Dihydrofolate reductase (trembl)


UD16_HUMAN UDP-glucuronosyltransferase 1-6 (sprot)

A UDP-glucuronosyltransferase 1-6 that is encoded in the genome of human.


UD19_HUMAN UDP-glucuronosyltransferase 1A9 (sprot)

A UDP-glucuronosyltransferase 1A9 that is encoded in the genome of human.


UD110_HUMAN UDP-glucuronosyltransferase 1A10 (sprot)

A UDP-glucuronosyltransferase 1A10 that is encoded in the genome of human.


PBPA_ECOLI Penicillin-binding protein 1A (sprot)

A penicillin-binding protein 1A that is encoded in the genome of Escherichia coli K-12.


Cephaloglycin

A cephalosporin antibiotic containing at the 7beta-position of the cephem skeleton an (R)-amino(phenyl)acetamido group.


Cefpiramide

A third-generation cephalosporin antibiotic with [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl and (R)-2-{[(4-hydroxy-6-methylpyridin-3-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It has a broad spectrum of antibacterial activity.


Cefotiam

One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.

A cephalosporin with ({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl and (2-amino-1,3-thiazol-4-yl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. A third generation beta-lactam cephalosporin antibiotic, it is active against a broad spectrum of both Gram positive and Gram negative bacteria.


Ceforanide

A second-generation cephalosporin antibiotic with {[1-(carboxymethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and 2-(aminomethyl)phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is effective against many coliforms, including Escherichia coli, Klebsiella, Enterobacter and Proteus, and most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Arizona species.


Cefmenoxime

A cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.

A third-generation cephalosporin antibiotic, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position and a [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl group at the 3-position.


O-Formylcefamandole

A cephalosporin compound having (R)-O-formylmandelamido and N-methylthiotetrazole side groups. It is used (as the sodium salt) as a progrug for cefamandole.


PBPB_ECOLI Penicillin-binding protein 1B (sprot)

A penicillin-binding protein 1B that is encoded in the genome of Escherichia coli K-12.


DACC_ECOLI D-alanyl-D-alanine carboxypeptidase DacC (sprot)

A D-alanyl-D-alanine carboxypeptidase DacC that is encoded in the genome of Escherichia coli K-12.


MRDA_ECOLI Peptidoglycan D,D-transpeptidase MrdA (sprot)

A peptidoglycan D,D-transpeptidase MrdA that is encoded in the genome of Escherichia coli K-12.


FTSI_ECOLI Peptidoglycan D,D-transpeptidase FtsI (sprot)

A peptidoglycan D,D-transpeptidase FtsI that is encoded in the genome of Escherichia coli K-12.


DACA_ECOLI D-alanyl-D-alanine carboxypeptidase DacA (sprot)

A D-alanyl-D-alanine carboxypeptidase DacA that is encoded in the genome of Escherichia coli K-12.


DACB_ECOLI D-alanyl-D-alanine carboxypeptidase DacB (sprot)

A D-alanyl-D-alanine carboxypeptidase DacB that is encoded in the genome of Escherichia coli K-12.


CCKAR_HUMAN Cholecystokinin receptor type A (sprot)

A cholecystokinin receptor 1 that is encoded in the genome of human.


GASR_HUMAN Gastrin/cholecystokinin type B receptor (sprot)

A cholecystokinin receptor 2 that is encoded in the genome of human.


CCKAR_RAT Cholecystokinin receptor type A (sprot)

A cholecystokinin receptor 1 that is encoded in the genome of rat.


GASR_RAT Gastrin/cholecystokinin type B receptor (sprot)

A cholecystokinin receptor 2 that is encoded in the genome of rat.


PTGES_HUMAN Prostaglandin E synthase (sprot)

A prostaglandin E synthase that is encoded in the genome of human.


Lonazolac

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 3-(4-chlorophenyl)-1-phenylpyrazol-4-yl group.


NMDE2_RAT Glutamate receptor ionotropic, NMDA 2B (sprot)

A glutamate receptor ionotropic, NMDA 2B that is encoded in the genome of rat.


GN_HHV11 Envelope glycoprotein N (sprot)

A protein that is a translation product of the gN gene in Herpes simplex virus type 1 strain 17.


GM_HHV11 Envelope glycoprotein M (sprot)

A protein that is a translation product of the gM gene in Herpes simplex virus type 1 strain 17.


GE_HHV11 Envelope glycoprotein E (sprot)

A protein that is a translation product of the gE gene in Herpes simplex virus type 1 strain 17.


GH_HHV11 Envelope glycoprotein H (sprot)

A protein that is a translation product of the gH gene in Herpes simplex virus type 1 strain 17.


GJ_HHV11 Envelope glycoprotein J (sprot)

A protein that is a translation product of the gJ gene in Herpes simplex virus type 1 strain 17.


GG_HHV11 Envelope glycoprotein G (sprot)

A protein that is a translation product of the gG gene in Herpes simplex virus type 1 strain 17.


GI_HHV11 Envelope glycoprotein I (sprot)

A protein that is a translation product of the gI gene in Herpes simplex virus type 1 strain 17.


GL_HHV11 Envelope glycoprotein L (sprot)

A protein that is a translation product of the gL gene in Herpes simplex virus type 1 strain 17.


GB_HHV11 Envelope glycoprotein B (sprot)

A protein that is a translation product of the gB gene in Herpes simplex virus type 1 strain 17.


GC_HHV11 Envelope glycoprotein C (sprot)


GK_HHV11 Envelope glycoprotein K (sprot)

A protein that is a translation product of the gK gene in Herpes simplex virus type 1 strain 17.


GD_HHV11 Envelope glycoprotein D (sprot)

A protein that is a translation product of the gD gene in Herpes simplex virus type 1 strain 17.


TP4A3_HUMAN Protein tyrosine phosphatase type IVA 3 (sprot)

A protein tyrosine phosphatase type IVA 3 that is encoded in the genome of human.


LEG8_HUMAN Galectin-8 (sprot)

A galectin-8 that is encoded in the genome of human.


CP130_MYCTU Cytochrome P450 130 (sprot)

A protein that is a translation product of the cyp130 gene in Mycobacterium tuberculosis H37Rv.


LDHA_HUMAN L-lactate dehydrogenase A chain (sprot)

An L-lactate dehydrogenase A chain that is encoded in the genome of human.


DNK_DROME Deoxynucleoside kinase (sprot)

A thymidine kinase 2, mitochondrial that is encoded in the genome of fruit fly.


KITM_HUMAN Thymidine kinase 2, mitochondrial (sprot)

A thymidine kinase 2, mitochondrial that is encoded in the genome of human.


HPSE_HUMAN Heparanase (sprot)

A heparanase that is encoded in the genome of human.


P72355_STAAU Penicillin-binding protein 4 (trembl)


Q53707_STAAU MecA PBP2' (penicillin binding protein 2') (trembl)


Q53725_STAAU Cell division protein FtsI (Peptidoglycan synthetase) (trembl)


Q53729_STAAU Penicillin-binding protein 2 (trembl)


Q9XDB3_STAAU Cell division protein FtsI [Peptidoglycan synthetase] / Transpeptidase, Penicillin binding protein transpeptidase domain, Penicillin-binding protein 3 (trembl)


Q54618_STREE Penicillin binding protein 2B (trembl)


Q75Y37_STREE serine-type D-Ala-D-Ala carboxypeptidase (trembl)


Q75Y54_STREE Penicillin-binding protein 2X (trembl)


Q75YD8_STREE PBP1A family penicillin-binding protein (trembl)


Q75YK0_STREE Penicillin-binding protein (trembl)


Q9RET4_STREE Penicillin-binding protein 1A (trembl)


PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase (sprot)

A protein-L-isoaspartate(D-aspartate) O-methyltransferase that is encoded in the genome of human.


PA21B_PIG Phospholipase A2, major isoenzyme (sprot)

A phospholipase A2 that is encoded in the genome of pig.


VDRA_DANRE Vitamin D3 receptor A (sprot)

A vitamin D3 receptor that is encoded in the genome of zebrafish.


PBPA_PSEAE Penicillin-binding protein 1A (sprot)

A penicillin-binding protein 1A that is encoded in the genome of Pseudomonas aeruginosa PAO1.


Q51504_PSEAI Peptidoglycan D,D-transpeptidase FtsI (trembl)

A protein that is a translation product of the ftsI gene in Pseudomonas aeruginosa.


Q51505_PSEAI Peptidoglycan D,D-transpeptidase FtsI (trembl)


Q9X6V3_PSEAI Peptidoglycan D,D-transpeptidase MrdA (trembl)


Q9X6V7_PSEAI serine-type D-Ala-D-Ala carboxypeptidase (trembl)


Q9X6W0_PSEAI Penicillin-binding protein 1B (trembl)


MYT1_HUMAN Myelin transcription factor 1 (sprot)

A myelin transcription factor 1 that is encoded in the genome of human.


Lypressin

The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.


V2R_HUMAN Vasopressin V2 receptor (sprot)

A vasopressin V2 receptor that is encoded in the genome of human.


V1AR_HUMAN Vasopressin V1a receptor (sprot)

A vasopressin V1a receptor that is encoded in the genome of human.


V1BR_HUMAN Vasopressin V1b receptor (sprot)

A vasopressin V1b receptor that is encoded in the genome of human.


JAK2_HUMAN Tyrosine-protein kinase JAK2 (sprot)

A tyrosine-protein kinase JAK2 that is encoded in the genome of human.


TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (sprot)

A non-receptor tyrosine-protein kinase TYK2 that is encoded in the genome of human.


IMPA1_HUMAN Inositol monophosphatase 1 (sprot)

An inositol monophosphatase 1 that is encoded in the genome of human.


E0V9R7_PEDHC Cytochrome P-450, putative (trembl)


E0VAD1_PEDHC Cytochrome P-450, putative (trembl)


E0VBK5_PEDHC Cytochrome P450, putative (trembl)


E0VCA5_PEDHC Cytochrome P450, putative (trembl)


E0VCW9_PEDHC Cytochrome P-450, putative (trembl)


E0VDM3_PEDHC Cytochrome P450, putative (trembl)


E0VDR0_PEDHC Cytochrome P450, putative (trembl)


E0VED4_PEDHC Cytochrome P-450, putative (trembl)


E0VGV6_PEDHC Cytochrome P450, putative (trembl)


E0VHL8_PEDHC Cytochrome P450, putative (trembl)


E0VHZ1_PEDHC Cytochrome P450, putative (trembl)


E0VJJ0_PEDHC Cytochrome P450, putative (trembl)


E0VM29_PEDHC Cytochrome P-450, putative (trembl)


E0VMV6_PEDHC Cytochrome P-450, putative (trembl)


E0VMV7_PEDHC Cytochrome P-450, putative (trembl)


E0VMW9_PEDHC Cytochrome P450, putative (trembl)


E0VQ45_PEDHC Cytochrome P-450, putative (trembl)


E0VQ46_PEDHC Cytochrome P-450, putative (trembl)


E0VQ47_PEDHC Cytochrome P-450, putative (trembl)


E0VRD2_PEDHC Cytochrome P-450, putative (trembl)


E0VSD4_PEDHC Cytochrome P450, putative (trembl)


E0VSD5_PEDHC Cytochrome P450, putative (trembl)


E0VUR0_PEDHC Cytochrome P450, putative (trembl)


E0VUR1_PEDHC Cytochrome P-450, putative (trembl)


E0VV39_PEDHC Cytochrome P-450, putative (trembl)


E0VV52_PEDHC Cytochrome P450, putative (trembl)


E0VV70_PEDHC Cytochrome P-450, putative (trembl)


E0VV72_PEDHC Cytochrome P-450, putative (trembl)


E0VXT9_PEDHC Cytochrome P450, putative (trembl)


E0VZW4_PEDHC Cytochrome P-450, putative (trembl)


E0W115_PEDHC Cytochrome P-450, putative (trembl)


E0W2B1_PEDHC Cytochrome P450, putative (trembl)


E0W389_PEDHC Cytochrome P-450, putative (trembl)


E0W4F7_PEDHC NADH-Ubiquinone oxidoreductase 39kDa subunit (trembl)


CP3A4_HUMAN Cytochrome P450 3A4 (sprot)

A cytochrome P450 3A4 that is encoded in the genome of human.


CP3A5_HUMAN Cytochrome P450 3A5 (sprot)

A cytochrome P450 3A5 that is encoded in the genome of human.


CP3A7_HUMAN Cytochrome P450 3A7 (sprot)

A cytochrome P450 3A7 that is encoded in the genome of human.


CP343_HUMAN Cytochrome P450 3A43 (sprot)

A cytochrome P450 3A43 that is encoded in the genome of human.


BGAL_HUMAN Beta-galactosidase (sprot)

A eukaryotic-type beta-galactosidase that is encoded in the genome of human.


CD20_HUMAN B-lymphocyte antigen CD20 (sprot)

A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human.


IL1B_HUMAN Interleukin-1 beta (sprot)

An interleukin-1 beta that is encoded in the genome of human.


CTLA4_HUMAN Cytotoxic T-lymphocyte protein 4 (sprot)

A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of human.


PAG_BACAN Protective antigen (sprot)

A protein that is a translation product of the pagA gene in Bacillus anthracis.


TNR8_HUMAN Tumor necrosis factor receptor superfamily member 8 (sprot)

A tumor necrosis factor receptor superfamily member 8 that is encoded in the genome of human.


TNF11_HUMAN Tumor necrosis factor ligand superfamily member 11 (sprot)

A tumor necrosis factor ligand superfamily member 11 that is encoded in the genome of human.


IL12A_HUMAN Interleukin-12 subunit alpha (sprot)

An interleukin-12 subunit alpha that is encoded in the genome of human.


IL12B_HUMAN Interleukin-12 subunit beta (sprot)

An interleukin-12 subunit beta that is encoded in the genome of human.


IL23A_HUMAN Interleukin-23 subunit alpha (sprot)

An interleukin-23 subunit alpha that is encoded in the genome of human.


CO5_HUMAN Complement C5 (sprot)

A complement C5 that is encoded in the genome of human.


Carprofen

anti-inflammatory drug (NSAID) of the propionic acid class with selective inhibition of COX-2 versus COX-1

Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.


AGRG3_HUMAN Adhesion G protein-coupled receptor G3 (sprot)

An adhesion G protein-coupled receptor G3 that is encoded in the genome of human.


ACKR3_HUMAN Atypical chemokine receptor 3 (sprot)

An atypical chemokine receptor 3 that is encoded in the genome of human.


Lauric Acid

A straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.


GPR84_HUMAN G-protein coupled receptor 84 (sprot)

A G-protein coupled receptor 84 that is encoded in the genome of human.


Octanoic acid

A straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid.


Corticorelin

A corticotropin-releasing hormone from human/rat composed of Ser, Glu, Glu, Pro, Pro, Ile, Ser, Leu, Asp, Leu, Val, Phe, His, Leu, Leu, Arg, Glu, Val, Leu, Glu, Met, Ala, Arg, Ala, Glu, Gln, Leu, Ala, Gln, Gln, Ala, His, Ser, Asn, Arg, Lys, Leu, Met, Glu, Ile and Ile-NH2 residues joined in sequence.


CRFR1_HUMAN Corticotropin-releasing factor receptor 1 (sprot)

A corticotropin-releasing factor receptor 1 that is encoded in the genome of human.


GHSR_HUMAN Growth hormone secretagogue receptor type 1 (sprot)

A growth hormone secretagogue receptor that is encoded in the genome of human.


FSHR_HUMAN Follicle-stimulating hormone receptor (sprot)

A follitropin receptor that is encoded in the genome of human.


NMUR2_HUMAN Neuromedin-U receptor 2 (sprot)

A neuromedin-U receptor 2 that is encoded in the genome of human.


T2R14_HUMAN Taste receptor type 2 member 14 (sprot)

A taste receptor type 2 member 14 that is encoded in the genome of human.


T2R46_HUMAN Taste receptor type 2 member 46 (sprot)

A taste receptor type 2 member 46 that is encoded in the genome of human.


KCNN1_HUMAN Small conductance calcium-activated potassium channel protein 1 (sprot)

A small conductance calcium-activated potassium channel protein 1 that is encoded in the genome of human.


CTSR1_HUMAN Cation channel sperm-associated protein 1 (sprot)

A cation channel sperm-associated protein 1 that is encoded in the genome of human.


CTSR2_HUMAN Cation channel sperm-associated protein 2 (sprot)

A cation channel sperm-associated protein 2 that is encoded in the genome of human.


CTSR4_HUMAN Cation channel sperm-associated protein 4 (sprot)

A cation channel sperm-associated protein 4 that is encoded in the genome of human.


5HT3B_HUMAN 5-hydroxytryptamine receptor 3B (sprot)

A 5-hydroxytryptamine receptor 3B that is encoded in the genome of human.


ACHA4_HUMAN Neuronal acetylcholine receptor subunit alpha-4 (sprot)

A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of human.


Hexamethonium

A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.


ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6 (sprot)

A neuronal acetylcholine receptor subunit alpha-6 that is encoded in the genome of human.


PDCD1_HUMAN Programmed cell death protein 1 (sprot)

A programmed cell death protein 1 that is encoded in the genome of human.


Gabexate

A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.


TRYB1_HUMAN Tryptase alpha/beta-1 (sprot)

A tryptase alpha/beta-1 that is encoded in the genome of human.


SO1B3_HUMAN Solute carrier organic anion transporter family member 1B3 (sprot)

A solute carrier organic anion transporter family member 1B3 that is encoded in the genome of human.


SC5A8_HUMAN Sodium-coupled monocarboxylate transporter 1 (sprot)

A sodium-coupled monocarboxylate transporter 1 that is encoded in the genome of human.


RYR2_RAT Ryanodine receptor 2 (sprot)

A ryanodine receptor 2 that is encoded in the genome of rat.


TYPH_ECOLI Thymidine phosphorylase (sprot)

A thymidine phosphorylase that is encoded in the genome of Escherichia coli K-12.


DPP4_RAT Dipeptidyl peptidase 4 (sprot)

A dipeptidyl peptidase 4 that is encoded in the genome of rat.


Q9TZZ6_TRYBG Ornithine decarboxylase (trembl)


OX1R_HUMAN Orexin/Hypocretin receptor type 1 (sprot)

An orexin/hypocretin receptor type 1 that is encoded in the genome of human.


F16P1_HUMAN Fructose-1,6-bisphosphatase 1 (sprot)

A fructose-1,6-bisphosphatase 1 that is encoded in the genome of human.


P2RY1_MELGA P2Y purinoceptor 1 (sprot)

A P2Y purinoceptor 1 that is encoded in the genome of turkey.


AT1A2_PIG Sodium/potassium-transporting ATPase subunit alpha-2 (sprot)


Proscillaridin

A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).


Ouabain

A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.

A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.


S28A1_HUMAN Sodium/nucleoside cotransporter 1 (sprot)

A sodium/nucleoside cotransporter 1 that is encoded in the genome of human.


SC5A2_HUMAN Sodium/glucose cotransporter 2 (sprot)

A sodium/glucose cotransporter 2 that is encoded in the genome of human.


JAK3_HUMAN Tyrosine-protein kinase JAK3 (sprot)

A tyrosine-protein kinase JAK3 that is encoded in the genome of human.


Esatenolol

The (S)-enantiomer of atenolol.


Toliprolol

was MH 1975-92 (see under PROPANOLAMINES 1981-90, was DOBEROL see under PROPANOLAMINES 1975-80); KOE 592 was see TOLIPROLOL 1975-92; use PROPANOLAMINES to search TOLIPROLOL 1975-92; beta adrenergic blockader with some stimulant action; it has been proposed for angina pectoris


Practolol

A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.

N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias.


Xamoterol

A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.


Tretoquinol

An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.


Prenalterol

A partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute CARDIAC FAILURE, postmyocardial infarction low-output syndrome, SHOCK, and reducing ORTHOSTATIC HYPOTENSION in the SHY-RAGER SYNDROME.


Etilefrine

A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent.


Dilevalol

A 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide that has 1R,2R-configuration.


Clorprenaline

A racemate comprise of equimolar amounts of (R)- and (S)-clorprenaline. It is a beta2-adrenergic receptor agonist and a bronchodilator.


Bopindolol

A methylindole that is 2-methyl-1H-indol-4-ol in which the hydrogen of the hydroxy group is replaced by a 2-(benzoyloxy)-3-(tert-butylamino)propyl group.


Bevantolol

a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension

A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by 3-methylphenyl and one of the hydrogens attached to the nitrogen is substituted by 2-(3,4-dimethoxyphenyl)ethyl. A beta1 adrenoceptor antagonist, it has been shown to be as effective as other beta-blockers for the treatment of angina pectoris and hypertension.


Alprenolol

One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

A secondary alcohol that is propan-2-ol substituted by a 2-allylphenoxy group at position 1 and an isopropylamino group at position 3. It is a beta-adrenergic antagonist used as a antihypertensive, anti-arrhythmia and a sympatholytic agent.


Levdobutamine

Levdobutamine, an investigational drug, is a  beta-adrenoceptor agonist selective for the beta1-subtype. It is the cardiotonic agent.

The (S)-enantiomer of dobutamine.


CNR1_HUMAN Cannabinoid receptor 1 (sprot)

A cannabinoid receptor 1 that is encoded in the genome of human.


Palmitoylethanolamide

a cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection; structure

An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid.


NR1I3_HUMAN Nuclear receptor subfamily 1 group I member 3 (sprot)

A nuclear receptor subfamily 1 group I member 3 that is encoded in the genome of human.


SCN3B_HUMAN Sodium channel subunit beta-3 (sprot)

A sodium channel subunit beta-3 that is encoded in the genome of human.


Hydroquinidine

urinary quinine metabolite; RN given refers to (9S)-isomer; structure in Merck Index, 9th ed, #4703


Deracoxib

A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3, and 5 by 4-sulfamoylphenyl, difluoromethyl and 3-fluoro-4-methoxyphenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs.


PGH1_HUMAN Prostaglandin G/H synthase 1 (sprot)

A prostaglandin G/H synthase 1 that is encoded in the genome of human.


Firocoxib

An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in horses and dogs.


Linolenic Acid

A fatty acid that is found in plants and involved in the formation of prostaglandins.

A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.


Eugenol

A cinnamate derivative of the shikamate pathway found in CLOVE OIL and other PLANTS.

A phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group. It is a major component of clove essential oil, and exhibits antibacterial, analgesic and antioxidant properties. It has been widely used in dentistry to treat toothache and pulpitis.


Linoleic Acid

A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)

An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.


Tolfenamic acid

An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.


Pirprofen

anti-inflammatory agent used in therapy of rheumatoid arthritis; prostaglandin synthetase inhibitor; more potent than indomethacin; structure


Oxametacin

A hydroxamic acid obtained by formal condensation of the carboxy group of indometacin with the amino group of hydroxylamine.


Monobenzone

The monobenzyl ether of hydroquinone.  It is used as a topical drug for medical depigmentation.


Mofezolac

Cyclooxygenase 1 inhibitor; ; RN from Toxlit


Isoxicam

A monocarboxylic acid amide that is piroxicam in which the pyrid-2-yl group is replaced by a 5-methyl-1,2-oxazol-3-yl group. A non-steroidal anti-inflammatory drug, it was withdrawn from the market in the 1980s following its association with cases of Stevens-Johnson syndrome.


Fenbufen

an orally active nonsteroidal anti-inflammatory drug with analgesic and antipyretic activity


Aminopyrine

A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.

A  pyrazolone  that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.


DPOL_HHV11 DNA polymerase catalytic subunit (sprot)

A protein that is a translation product of the UL30 gene in Herpes simplex virus type 1 strain 17.


DPOL_VZVD DNA polymerase catalytic subunit (sprot)


Zilpaterol

Is an adrenergic drug currently licensed in Mexico and South Africa as feed additive for cattle close to consignment


OPRM_HUMAN Mu-type opioid receptor (sprot)

A mu-type opioid receptor that is encoded in the genome of human.


A narcotic analgesic morphinan used as sedative in veterinary practice


Diprenorphine

A narcotic antagonist similar in action to NALOXONE. It is used to remobilize animals after ETORPHINE neuroleptanalgesia and is considered specific antagonist to etorphine


Ciramadol

benzylamine analgesics; structure given in fourth source


Phenazocine

An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)


Penfluridol

One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.


Nalorphine

A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.


Levallorphan

An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)


Dihydroergocristine

A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position of the molecule.

Ergocristine in which a single bond replaces the double bond between positions 9 and 10. It is used as the mesylate salt for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease.


alpha-Ergocryptine

a component of the ergotoxine complex; it is the main ergot alkaloid of Japanese & South American wid grasses; minor descriptor (76-86); on-line & INDEX MEDICUS search ERGOLINES (76-86); RN given refers to ((5'alpha)-isomer)

Ergotaman bearing hydroxy, isopropyl, and 2-methylpropyl groups at the 12', 2' and 5' positions, respectively, and oxo groups at positions 3', 6', and 18. It is a natural ergot alkaloid. Ergocryptine discussed in the literature prior to 1967, when beta-ergocryptine was separated from alpha-ergocryptine, is now referred to as alpha-ergocryptine.


Anileridine

minor descriptor (64-86); on line & INDEX MEDICUS search ISONIPECOTIC ACIDS (68-86); RN given refers to parent cpd

A piperidinecarboxylate ester that is the ethyl ester of isonipecotic acid in which the hydrogen alpha- to the carboxyl group is substituted by a phenyl group, and the hydrogen attached to the nitrogen is substituted by a 2-(4-aminophenyl)ethyl group.


DRD1_HUMAN D(1A) dopamine receptor (sprot)

A D(1A) dopamine receptor that is encoded in the genome of human.


Periciazine

A member of the class of  phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.


Metergoline

A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.

An ergoline alkaloid that is the N-benzyloxycarbonyl derivative of lysergamine. A 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.


Bromperidol

bromine-substituted for chlorine in haloperidol; RN given refers to unlabeled parent cpd; structure


Acepromazine

Acepromazine, a phenothiazine derivatives, was first used in the 1950s in the treatment of PSYCHOSES. Now, it is commonly used as tranquilizer/sedative agent in dogs, cats, horses, and other animals. It is thought to block dopamine receptors in the brain or inhibit the activity of dopamine in other ways.

A member of the class of  phenothiazines that is 10H-phenothiazine substituted by an acetyl group at position 2 and a 3-(dimethylamino)propyl group at position 10.


NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (sprot)

A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human.


SCNNA_HUMAN Amiloride-sensitive sodium channel subunit alpha (sprot)

An amiloride-sensitive sodium channel subunit alpha that is encoded in the genome of human.


UROK_HUMAN Urokinase-type plasminogen activator (sprot)

A urokinase-type plasminogen activator that is encoded in the genome of human.


Silibinin

A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.

A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.


Oxfendazole

A member of the class of benzimidazoles that is fenbendazole in which the sulfur has been oxidised to the corresponding sulfoxide.


THA_HUMAN Thyroid hormone receptor alpha (sprot)

A thyroid hormone receptor alpha that is encoded in the genome of human.


Lidoflazine

Coronary vasodilator with some antiarrhythmic action.


Clebopride

antidopaminergic; RN given refers to parent cpd; structure


Triparanol

Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts.


A 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase that is encoded in the genome of human.


Trifluperidol

A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)


MDR1_HUMAN ATP-dependent translocase ABCB1 (sprot)

An ATP-dependent translocase ABCB1 that is encoded in the genome of human.


Daunorubicinol

The (13S)-diastereomer of 13-dihydrodaunorubicin.


SC6A4_HUMAN Sodium-dependent serotonin transporter (sprot)

A sodium-dependent serotonin transporter that is encoded in the genome of human.


Femoxetine

serotonin uptake inhibitor; RN given refers to (3R-trans)-isomer


Zimeldine

One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385)


Suloctidil

A peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)


Nomifensine

An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)

An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.


Iprindole

A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE, but has only weak antimuscarinic and sedative effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p257)


Ethylestrenol

An anabolic steroid with some progestational activity and little androgenic effect.

A 17beta-hydroxy steroid that is estrane containing a double bond between positions 4 and 5 and substituted by an ethyl group and a hydroxy group at the 17alpha and 17beta positions, respectively. It is an anabolic steroid that has little androgenic effect and only slight progestational activity. It has been used to promote growth in boys with delayed bone growth.


Estradiol benzoate

The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids

A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.


SC6A2_HUMAN Sodium-dependent noradrenaline transporter (sprot)

A sodium-dependent noradrenaline transporter that is encoded in the genome of human.


Bethanidine

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear.


5HT2B_HUMAN 5-hydroxytryptamine receptor 2B (sprot)

A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human.


Dihydroergocryptine

A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position and an alpha-isobutyl sidechain at 5'alpha position of the molecule.

alpha-Ergocryptine in which a single bond replaces the double bond between positions 9 and 10.


Tirilazad

a lazaroid; potent inhibitor of iron-dependent lipid peroxidation; has shown excellent activity in in vivo models of experimental central nervous system trauma & ischemia; structure given in first source; tradename Freedox


Xanomeline

a cholinergic agonist; used in the treatment of Alzheimer's disease; structure given in first source


Pizotifen

Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.

A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety by a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.


Desoxycortone

A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE

A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.


Indoramin

An alpha-1 adrenergic antagonist that is commonly used as an antihypertensive agent.


Azaperone

A butyrophenone used in the treatment of PSYCHOSES

An N-arylpiperazine that is 2-(piperazin-1-yl)pyridine in which the amino hydrogen is replaced by a 3-(4-fluobenzoyl)propyl group. Used mainly as a tranquiliser for pigs and elephants.


DRD3_HUMAN D(3) dopamine receptor (sprot)

A D(3) dopamine receptor that is encoded in the genome of human.


Clorotepine

major tranquilizer with action similar to those of the phenothiazines; used in schizophrenic & manic psychoses; minor decriptor (77-86); on-line & INDEX MEDICUS search DIBENZOTHIEPINS (77-86); RN given refers to parent cpd without isomeric designation


Thioproperazine

A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10.


Remoxipride

An antipsychotic agent that is specific for dopamine D2 receptors. It has been shown to be effective in the treatment of schizophrenia.


Nemonapride

an atypical antipsychotic approved in Japan for the treatment of schizophrenia

A racemate composed of (2S,3S)- and (2R,3R)-enantiomers of nemonapride. Highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.


HRH1_HUMAN Histamine H1 receptor (sprot)

A histamine H1 receptor that is encoded in the genome of human.


Azacyclonol

major descriptor (65-84); on-line search PIPERIDINES (65-84); Index Medicus search AZACYCLONOL (65-84); RN given refers to parent cpd


Bisulepine

The (Z)-isomer of dithiadene.


HRH2_HUMAN Histamine H2 receptor (sprot)

A histamine H2 receptor that is encoded in the genome of human.


Ebrotidine

an H2-receptor antagonist and gastric mucosa protector


ACM1_HUMAN Muscarinic acetylcholine receptor M1 (sprot)

A muscarinic acetylcholine receptor M1 that is encoded in the genome of human.


Sabcomeline

selective for M1 receptors; RN refers to (R,S)-isomer


Pridinol

antispasmodic & muscle relaxant; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7539

A piperidine substituted at position 1 by a 3-hydroxy-3,3-diphenylpropyl group.


Oxyphenonium

A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect.


Minaprine

Agr 1240 refers to di-HCl; short-acting type A MAO inhibitor (MAOI) of mild potency; structure


Triethylgallamine

A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)


A non-depolarizing skeletal muscle relaxant similar to TUBOCURARINE. It is used as an anesthesia adjuvant, for endotracheal intubation and to produce muscle relaxation in general anesthesia during surgical procedures.


ACM3_HUMAN Muscarinic acetylcholine receptor M3 (sprot)

A muscarinic acetylcholine receptor M3 that is encoded in the genome of human.


AOXA_HUMAN Aldehyde oxidase (sprot)

An aldehyde oxidase that is encoded in the genome of human.


PBPA_CLOPE Penicillin-binding protein 1A (sprot)


Cefacetrile

A derivative of 7-aminocephalosporanic acid.


PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (sprot)

A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A that is encoded in the genome of human.


Enoximone

A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.


Thiamphenicol

A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent.


RL10_HALMA Large ribosomal subunit protein uL10 (sprot)


MRP2_HUMAN ATP-binding cassette sub-family C member 2 (sprot)

An ATP-binding cassette sub-family C member 2 that is encoded in the genome of human.


PBPC_BACSU Penicillin-binding protein 3 (sprot)

A protein that is a translation product of the pbpC gene in Bacillus subtilis subsp. subtilis str. 168.


GCR_HUMAN Glucocorticoid receptor (sprot)

A glucocorticoid receptor that is encoded in the genome of human.


Fluprednisolone

A synthetic glucocorticoid with anti-inflammatory properties.


Ethisterone

17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects.

A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.


Dexamethasone palmitate

a liposteroid for treatment of hemophagocytic lymphohistiocytosis


ANXA1_HUMAN Annexin A1 (sprot)

An annexin A1 that is encoded in the genome of human.


5HT1B_HUMAN 5-hydroxytryptamine receptor 1B (sprot)

A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human.


5HT1D_HUMAN 5-hydroxytryptamine receptor 1D (sprot)

A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human.


IL5_HUMAN Interleukin-5 (sprot)

An interleukin-5 that is encoded in the genome of human.


IFNG_HUMAN Interferon gamma (sprot)

An interferon gamma that is encoded in the genome of human.


SC6A3_HUMAN Sodium-dependent dopamine transporter (sprot)

A sodium-dependent dopamine transporter that is encoded in the genome of human.


CP2D6_HUMAN Cytochrome P450 2D6 (sprot)

A cytochrome P450 2D6 that is encoded in the genome of human.


AA1R_HUMAN Adenosine receptor A1 (sprot)

An adenosine receptor A1 that is encoded in the genome of human.


Etofylline

etophyllin appeared once in PubMed: Wien Med Wochenschr. 1986 May 15;136(9):213-8 as a combination drug with theophylline (spelt without e, theophllin)


NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (sprot)

A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human.


Flutrimazole

An imidazole antifungal agent that is imidazole in which the hydrogen attached to the nitrogen is replaced by a 2,4'-difluorotrityl group. A topical antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts.


GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2 (sprot)

A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of human.


GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2 (sprot)

A gamma-aminobutyric acid receptor subunit rho-2 that is encoded in the genome of human.


DRD4_HUMAN D(4) dopamine receptor (sprot)

A D(4) dopamine receptor that is encoded in the genome of human.


KCJ11_HUMAN ATP-sensitive inward rectifier potassium channel 11 (sprot)

An ATP-sensitive inward rectifier potassium channel 11 that is encoded in the genome of human.


PARC_ECOLI DNA topoisomerase 4 subunit A (sprot)

A DNA topoisomerase 4 subunit A that is encoded in the genome of Escherichia coli K-12.


PARC_BACSU DNA topoisomerase 4 subunit A (sprot)


GYRA_MYCTU DNA gyrase subunit A (sprot)

A DNA gyrase subunit A that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


Pefloxacin

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.

A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.


GYRA_ECOLI DNA gyrase subunit A (sprot)

A DNA gyrase subunit A that is encoded in the genome of Escherichia coli K-12.


Fleroxacin

A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.

A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.


BLAT_ECOLX Beta-lactamase TEM (sprot)

A protein that is a translation product of any of the plasmid-encoded copies of the blaTEM gene in Escherichia coli.


Levonordefrin

A catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry.


Emetine

The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.

A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.


5HT3A_HUMAN 5-hydroxytryptamine receptor 3A (sprot)

A 5-hydroxytryptamine receptor 3A that is encoded in the genome of human.


Octopamine

An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.

A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.


INDISETRON

an anti-emetic agent, indisetron hydrochloride was developed in Japan


Azasetron

a selective 5-HT3 receptor antagonist; structure given in first source


SC6A1_HUMAN Sodium- and chloride-dependent GABA transporter 1 (sprot)

A sodium- and chloride-dependent GABA transporter 1 that is encoded in the genome of human.


OPRK_HUMAN Kappa-type opioid receptor (sprot)

A kappa-type opioid receptor that is encoded in the genome of human.


PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A (sprot)

A peptidyl-prolyl cis-trans isomerase A that is encoded in the genome of human.


DHPS1_MYCLE Dihydropteroate synthase (sprot)

A dihydropteroate synthase that is encoded in the genome of Mycobacterium leprae TN.


CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit (sprot)

A voltage-dependent calcium channel gamma-1 subunit that is encoded in the genome of human.


IL4_HUMAN Interleukin-4 (sprot)

An interleukin-4 that is encoded in the genome of human.


CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human.


TOP2A_HUMAN DNA topoisomerase 2-alpha (sprot)

A DNA topoisomerase 2-alpha that is encoded in the genome of human.


Carubicin

A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.

A toxic anthracycline antibiotic that is produced by Actinomadura carminata and also has potent antineoplastic activity.


Asulacrine

derivative of amsacrine; structure given in first source


ABCG2_HUMAN Broad substrate specificity ATP-binding cassette transporter ABCG2 (sprot)

A broad substrate specificity ATP-binding cassette transporter ABCG2 that is encoded in the genome of human.


RS9_ECOLI Small ribosomal subunit protein uS9 (sprot)

A 30S ribosomal protein S9 that is encoded in the genome of Escherichia coli K-12.


EMBB_MYCTO Probable arabinosyltransferase B (sprot)


EMBC_MYCTU Probable arabinosyltransferase C (sprot)


NMD3A_HUMAN Glutamate receptor ionotropic, NMDA 3A (sprot)

A glutamate receptor ionotropic, NMDA 3A that is encoded in the genome of human.


GLRA1_HUMAN Glycine receptor subunit alpha-1 (sprot)

A glycine receptor subunit alpha-1 that is encoded in the genome of human.


Picrotin

the less toxic component of picrotoxin lacking GABA activity

An organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity.


A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.

A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.


Methoxyflurane

An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)

An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.


D-Fructose

A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.

A ketohexose that is an isomer of glucose.


GLRA2_HUMAN Glycine receptor subunit alpha-2 (sprot)

A glycine receptor subunit alpha-2 that is encoded in the genome of human.


gamma-Linolenic acid

An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed)

A C18, omega-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.


S5A2_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (sprot)

A 3-oxo-5-alpha-steroid 4-dehydrogenase 2 that is encoded in the genome of human.


CP51_CANAL Lanosterol 14-alpha demethylase (sprot)

A protein that is a translation product of the ERG11 gene in Candida albicans SC5314.


TYSY_HUMAN Thymidylate synthase (sprot)

A thymidylate synthase that is encoded in the genome of human.


MRP8_HUMAN ATP-binding cassette sub-family C member 11 (sprot)

An ATP-binding cassette sub-family C member 11 that is encoded in the genome of human.


DPOL_HCMVA DNA polymerase catalytic subunit (sprot)


Coumaphos

A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as nematocide


CAH1_HUMAN Carbonic anhydrase 1 (sprot)

A vertebrate-type carbonic anhydrase 1 that is encoded in the genome of human.


Ethylparaben

An ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol,


Paraoxon

An organophosphate cholinesterase inhibitor that is used as a pesticide.

An aryl dialkyl phosphate where both the alkyl groups are ethyl and the aryl group is 4-nitrophenyl.


2,5-Dihydroxybenzoic acid

A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.


Methylparaben

used as a preservative in cosmetics but potentiates UV-induced damage of skin; RN given refers to parent cpd

A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blueberries.


Coumarin

effective in reducing edema following crush & thermal injury; structure in Merck Index, 9th ed, #2547; Coumarin itself occurs in the Tonka bean

A chromenone having the keto group located at the 2-position.


ABCC9_HUMAN ATP-binding cassette sub-family C member 9 (sprot)

An ATP-binding cassette sub-family C member 9 that is encoded in the genome of human.