Ivory Exostosis

An osteoma that develops on the surface of the bone.


Chemically Induced Toxicity

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Recurrent Low Grade Fallopian Tube Serous Adenocarcinoma

The reemergence of low grade fallopian tube serous adenocarcinoma after a period of remission.


Decreased Drug AUC

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Decreased area under the plot of plasma concentration of a drug against time after drug administration.


Minimal Deviation Melanoma

A melanocytic neoplasm displaying morphologic features that are intermediate between those of benign nevus and melanoma.  It is characterized by a nodular architectural growth resembling a melanoma, and a loss of nevus cell maturation.  The melanocytic cells forming the nodular growth are uniform, and they may display a high mitotic rate, but they do not show cytologic atypia.


Adult Benign Cerebral Neoplasm

A benign neoplasm of the cerebrum occurring in adults.


Stage IIA2 Cervical Cancer FIGO 2009

Cervical carcinoma limited to the upper two-thirds of the vagina and measuring more than 4 cm in diameter. (FIGO 2009)


Prostate Acinar Pleomorphic Giant Cell Adenocarcinoma

An extremely rare prostate acinar adenocarcinoma characterized by the presence of giant, bizarre anaplastic cells with pleomorphic nuclei and lack of a spindle cell component.


FIGO Stage IVA Gestational Trophoblastic Tumor


Cusp tear

A split located on a leaflet of a heart valve that prevents its complete closing, which can result in valvular dysfunction.


Papillary squamous cell carcinoma, non-invasive

A well differentiated squamous cell carcinoma characterized by a papillary, exophytic growth pattern, hyperkeratosis, and absence of invasion of adjacent tissues.


Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with Low Grade Dysplasia

An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of low grade dysplasia.


Viral endocarditis

Endocarditis caused by a viral infection.


Refractory Neoplastic Post-Transplant Lymphoproliferative Disorder

Neoplastic post-transplant lymphoproliferative disorder that is resistant to treatment.


AHL Amyloidosis

An extremely rare type of amyloidosis characterized by the monoclonal deposition of immunoglobulin heavy chain and light chain fragments in organs and tissues.


Bone Rosai-Dorfman Disease

Rosai-Dorfman-Destombes disease affecting the bone.


Subarachnoid Hemorrhage Related to Birth

Bleeding within the subarachnoid space occurring during labor and/or delivery.


Unresectable Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that is not amenable to surgical resection.


Neoplasm, malignant, uncertain whether primary or metastatic

A malignant neoplasm in which the examined tissue can not be determined with certainty if it represents the primary site of tumor growth or tumor spread from another anatomic site.


Non-Neoplastic Brain Disorder

A non-neoplastic disorder that affects the brain. Representative examples include cerebrovascular disorder, hydrocephalus, and encephalitis.


Stage II Bone Sarcoma AJCC v7

Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Unresectable Urethral Urothelial Carcinoma

Urethral urothelial carcinoma that is not amenable to surgical resection.


Stage I Appendix Neuroendocrine Tumor AJCC v7

Stage I includes: T1, N0, M0. T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Florid Follicular Hyperplasia Post-Transplant Lymphoproliferative Disorder

An early lesion of post-transplant lymphoproliferative disorder with the morphologic appearance of florid follicular hyperplasia.


Infarction of brain due to migraine

Migraine associated with an ischemic brain lesion.


Malignant Hair Follicle Neoplasm

A neoplasm that arises from the hair follicle and metastasizes to other anatomic sites.


Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8

Stage IIIB includes: T1-4, N1b-3, M0. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Acute promyelocytic leukemia - hypogranular variant

Acute promyelocytic leukemia in which the promyelocytes in the peripheral blood have paucity or absence of cytoplasmic granules and characteristic bilobed nuclei.


Prostate Acinar Oncocytic Adenocarcinoma

An exceptionally rare acinar prostate adenocarcinoma characterized by the presence of malignant large cells with granular eosinophilic cytoplasm.


Meningeal Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Infiltration of the meninges by chronic myeloid leukemia, BCR-ABL1 positive.


Stage IV Ampulla of Vater Neuroendocrine Tumor AJCC v8

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Congenital listeriosis

A bacterial infection by Listeria monocytogenes that is present at birth.


Mullerian Papilloma

A benign papillary neoplasm that arises from the cervix or vagina. It mostly occurs in prepubertal girls and rarely in adolescents or young adults. It is characterized by the presence of a fibrovascular core covered by cuboidal or columnar epithelial cells. Squamous metaplasia may be present. Cytologic atypia is absent.


Contact dermatitis due to alkali

Contact dermatitis caused by exposure to alkalis.


Adult Diffuse Large Cell Lymphoma

A B-or T-cell non-Hodgkin lymphoma composed of a diffuse large cell lymphocytic infiltrate occurring in adults.


Aplastic anemia due to radiation

Aplastic anemia caused by excessive absorption of radiation by the bone marrow.


Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential

A premalignant neurofibromatous neoplasm characterized by the presence of at least two of the following features: cytologic atypia, hypercellularity, less than 3 mitotic figures per 10 HPFs, and loss of neurofibroma architecture. It is associated with an increased risk of progression to malignant peripheral nerve sheath tumor.


Leukemia, Radiation-Induced

Leukemia that is caused by radiation.


Congenital anomaly of lens

Any anatomic abnormality or physiologic dysfunction of the lens of the eye that is present at the time of birth.


Average Body Weight Gain

The mean value of the amount of weight gained over a period of time.


Stage IIIB Esophageal Cancer AJCC v7

Stage IIIB includes: For squamous cell carcinoma: T3, N2, M0, Any G, Tumor location: Any. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Brief depressive adjustment reaction

Temporary maladaptive depressive signs and symptoms associated with a life event.


Epithelioid glioblastoma

An IDH-wildtype glioblastoma characterized by the presence of large epithelioid cells with abundant eosinophilic cytoplasm, vesicular chromatin, and prominent nucleoli.


Arsenical keratosis

A hyperkeratotic skin lesion that occurs in patients who have been exposed to arsenic.


Radiating Chest Pain to Other Location

An indication that the chest pain radiates to a location other than those listed.


Stage I Gestational Trophoblastic Neoplasm AJCC v8

Stage I includes: T1, M0. T1: Gestational trophoblastic neoplasm in which the tumor is confined to uterus. M0: No distant metastasis. (AJCC 8th Ed.)


round cell sarcoma with EWSR1-PATZ1 gene fusion

A group of rare round and spindle cell sarcomas characterized by the presence of EWSR1-PATZ1 gene fusion.


Unresectable Neuroendocrine Carcinoma

Neuroendocrine carcinoma that is not amenable to surgical resection.


Uterine Ligament Ependymoma

A rare neoplasm that arises from the broad or other uterine ligaments and shows ependymal differentiation.


Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor

A usually indolent neuroendocrine neoplasm that almost exclusively arises in the second part of the duodenum. Rare sites of involvement include jejunum, pylorus, appendix, thymus, and lung. It is a triphasic tumor consisting of a mixture of epithelioid neuroendocrine cells, Schwann-like cells, and ganglion cell-like elements.


Stage 0 Esophageal Adenocarcinoma AJCC v7

Stage 0 includes: Tis (HGD), N0, M0, G1,GX.  Tis: High-grade dysplasia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Squamous Hyperplasia

A hyperplasia of the squamous epithelial cells.


Dry Desquamation

A skin reaction characterized by scaling and pruritus.


Malignant Neoplasm of Lung - Multiple Primary Sites

Lung cancer comprising malignant neoplasms from two or more sites, as determined by clinicoopathological assessment.


Epigastric hernia

Protrusion of abdominal cavity contents or pre-peritoneal fat through the abdominal wall between the umbilicus and the xiphoid process.


Lacrimal Gland Warthin Tumor

A rare benign tumor that arises from the lacrimal gland. It is characterized by an oncocytic epithelial component and dense lymphoid stroma.


Benign Dermal Neoplasm

A neoplasm that arises from the dermis and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Cutaneous Melanoma by AJCC v7 Stage

A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v7 classification system.


Advanced Favorable Hodgkin Lymphoma

An advanced Hodgkin lymphoma with favorable prognosis.


Non-Neoplastic Pleural Disorder

A non-neoplastic disorder that affects the pleura.  Representative examples include pleural infection and pneumothorax.


Childhood Compound Nevus

A compound nevus that occurs during childhood.


Trigeminal nerve palsy

Partial or complete paralysis of the trigeminal nerve.


Abnormal Cardiac Study

A history of having had an abnormal cardiac study.


Overt Stroke

A cerebral infarction that is evident by new neurological symptoms lasting greater than 24 hours or having an area of diffusion restriction or a T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensity on an MRI of the brain that was consistent with the neurological findings.


Placental Site Nodule and Plaque Occurring in the Fallopian Tube

A rare non-neoplastic trophoblastic disorder characterized by the presence of remnants of intermediate trophoblasts in the fallopian tube from a previous pregnancy.


Locally Advanced Pancreatic Carcinoma

A pancreatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Childhood Acute Erythroid Leukemia

An acute erythroid leukemia occurring in children.


Verrucous carcinoma of the oral cavity stage I


Refractory Endometrial Serous Adenocarcinoma

Endometrial serous adenocarcinoma that is resistant to treatment.


Lacrimal Drainage System Adenoid Cystic Carcinoma

A carcinoma that arises from the lacrimal sac. It is characterized by the presence of malignant epithelial cells that form cribriform, tubular, and solid patterns.


Recurrent Endometrial Dedifferentiated Carcinoma

The reemergence of endometrial dedifferentiated carcinoma after a period of remission.


Adult Benign Brain Neoplasm

A benign neoplasm of the brain occurring in adults.


Metastatic Prostate Adenocarcinoma with Neuroendocrine Differentiation

Prostate adenocarcinoma with neuroendocrine differentiation that has spread from its original site of growth to another anatomic site.


Perforation

A hole or opening made through a membrane or other tissue or material.


Metastatic Platinum-Resistant Malignant Germ Cell Tumor

A platinum-resistant malignant germ cell tumor that has spread from its original site of growth to another anatomic site.


Adnexal Adenocarcinoma, Not Otherwise Specified

An adnexal carcinoma with ductal/glandular differentiation lacking specific histological features that would allow further classification. (WHO 2018)


A hematologic malignancy that arises in a patient with a history of organ transplantation.


Childhood Benign Skin Neoplasm

A childhood neoplasm that arises from the skin and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Recurrent Endometrial Cancer

The reemergence of endometrial carcinoma after a period of remission.


Complex endometrial hyperplasia without atypia

A hyperplasia characterized by excessive proliferation of endometrial cells, resulting in the formation of complex epithelial structures. Epithelial atypia is absent.


Metastatic adenoid cystic carcinoma

An adenoid cystic carcinoma that has spread from the original site of growth to other anatomic sites.


Epstein-Barr virus infection recurrent

An Epstein-Barr virus infection that has recurred after a period of remission.


Cervical myelocele

Herniation of spinal cord tissue and meninges through a defect in the cervical region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Metastatic Malignant Neoplasm in the Lacrimal System

A malignant neoplasm that has spread from its original site of growth to the lacrimal gland or lacrimal drainage system.


Nutritional Hypophosphatemic Rickets

Hypophosphatemic rickets due to insufficient dietary phosphate intake or absorption.


Hyperlipasaemia

A laboratory test result which indicates increased levels of lipase in a biologic specimen.


Adult Intracranial Germ Cell Tumor

A germ cell tumor that arises within the cranium and occurs during adulthood.


Stage I Childhood Retinoblastoma by Toronto Guidelines v2

Enucleation with negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Phlebitis of portal vein

Inflammation of the portal vein.


Basal-Like Prostate Carcinoma

Prostate carcinoma in which the CD49f signature is increased, the luminal markers and androgen receptor expression and signaling (androgen activity pathway) are not increased, and the proliferation score is higher than the luminal A prostate carcinoma.


Stage II Gallbladder Cancer AJCC v7

Stage II includes: T2, N0, M0.  T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Gestational diabetes mellitus class A2

Carbohydrate intolerance first diagnosed during pregnancy. Diagnosis from abnormal oral glucose tolerance test (OGTT) and abnormal fasting or post-prandial glucose levels. Euglycemia achieved with medication.


Stage II Intermediate Grade Adult Non-Hodgkin's Lymphoma


Stage IIIA Uterine Corpus Cancer AJCC v8

Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus carcinoma or carcinosarcoma with tumor involving the serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Unresectable Digestive System Carcinoma

Digestive system carcinoma that is not amenable to surgical resection.


Recurrent basal cell carcinoma

The reemergence of basal cell carcinoma after a period of remission.


Unacceptable Toxicity

Therapy-related toxicity leading to multiple treatment dose reductions or delays, early treatment stoppage, unplanned hospital admission, or death.


Refractory Childhood Malignant Neoplasm

A childhood malignant neoplasm that does not respond to treatment.


Cutaneous Melanoma by AJCC v8 Pathologic Stage

A term that refers to the pathologic staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


Current EBV Infection

Epstein-Barr virus infection is evident at the time of testing.


Infection pyogenic

An infection caused by pus-producing organisms.


Childhood Ependymoma by Toronto Guidelines v2 Stage, Tier 1

A term that refers to the staging of childhood ependymoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Vasculitic ulcer

A circumscribed inflammatory lesion associated with underlying ischemic disease.


Pulmonary Embolism Related to COVID-19

Pulmonary embolism in a patient with probable or confirmed acute COVID-19.


Third degree uterine prolapse

The uterus has descended below the level of the hymen and protrudes through the opening of the vagina.


Stage III Pancreatic Cancer AJCC v6 and v7

Stage III includes: T4, Any N, M0. T4: Tumor involves the celiac axis or the superior mesenteric artery.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Adverse event

Any unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure. Such events can be related to the intervention, dose, route of administration, patient, or caused by an interaction with another drug(s) or procedure(s).


Recurrent Acute Myeloid Leukemia with Multilineage Dysplasia

The reemergence of acute myeloid leukemia with multilineage dysplasia after a period of remission.


Stage IVB Appendix Carcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1b, G2, G3, or GX. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. G2: Moderately differentiated. G3: Poorly differentiated. GX: Grade cannot be assessed.  (AJCC 8th ed.)


Metastatic Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma that has spread to another anatomic site.


Non-Neoplastic Trigeminal Nerve Disorder

A non-neoplastic disorder affecting the trigeminal nerve.


Serum Soluble Fas Ligand Level Increased

An indication that the concentration of soluble Fas ligand in a sample has increased when compared to a normal baseline or a previous sample measurement.


Stage II Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

Tumor extends beyond kidney but completely resected. Tumor penetrates renal capsule. Tumor in lymphatics or veins of renal sinus. Tumor in renal vein with margin not involved. No nodal or hematogenous metastases. Negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Unresectable Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is not amenable to surgical resection.


Edema Trunk

Swelling due to an excessive accumulation of fluid in trunk area.


Pelvic Floor Disorders

A disorder affecting the muscles of the pelvic floor.


FIGO Stage IV Gestational Trophoblastic Tumor

Gestational trophoblastic tumor in all other metastatic sites.


Enteric campylobacteriosis

A gastrointestinal infection attributed to the bacteria campylobacter. It is usually contracted by consuming raw or undercooked poultry or consuming a food that has been in contact with raw poultry. It is characterized by abdominal pain, fever, and  diarrhea and usually resolves in two to five days.


Focal KATP-Associated Hyperinsulinism

KATP-associated hyperinsulinism in which there is an area of adenomatous beta-cell hyperplasia. This condition results from paternal recessive mutation(s) in either the ABCC8 or the KCNJ11 gene and paternal uniparental isodisomy of chromosome region 11p15 with loss of tumor suppressor genes expressed from the maternally inherited chromosome.


Locally Advanced High Grade Sarcoma

High grade sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Benign Childhood Central Nervous System Neoplasm

A childhood neoplasm that arises from the central nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


FIGO Stage IIIB Gestational Trophoblastic Tumor


Rhinovirus infection

An infectious process caused by rhinovirus. The virus usually causes upper respiratory infections, but can infect the lower tract as well.


Stage IVB Vulvar Cancer AJCC v6 and v7

Stage IVB includes: Any T, Any N, M1.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 6th and 7th eds.)


Hemophilus influenza infection

An infection that is caused by the organism Hemophilus influenza.


Recurrent Adult Diffuse Mixed Cell Lymphoma

The reemergence of adult diffuse mixed cell lymphoma after a period of remission.


Refractory Carcinoma

A carcinoma that does not respond to treatment.


Multifocal Glioblastomas

The occurrence of multiple and independent glioblastomas that are unrelated to inherited neoplastic syndromes.


Metastatic Digestive System Neuroendocrine Tumor G3

Digestive system neuroendocrine tumor G3 that has spread from its original site of growth to another anatomic site.


Gastroenteritis enteroviral

Gastroenteritis resulting from an infection with enterovirus.


Accelerated Phase Primary Myelofibrosis

Rapid progression of primary myelofibrosis, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


Resectable Platinum-Resistant Malignant Germ Cell Tumor

A platinum-resistant malignant germ cell tumor that is amenable to surgical resection.


Childhood Favorable Prognosis Hodgkin Lymphoma

A Hodgkin lymphoma with favorable prognosis that occurs during childhood.


Advanced Gallbladder Carcinoma

Gallbladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Prostate Carcinoma by Gene Expression Profile

A header term that includes the following prostate carcinoma subtypes determined by gene expression profiling: luminal A prostate carcinoma, luminal B prostate carcinoma, and basal-like prostate carcinoma.


Prostatic Basal Cell Hyperplasia

A type of prostatic hyperplasia.  It is characterized by the presence of nodules of dark basal cells around residual prostatic secretory cells.


Recurrent Acute Myeloid Leukemia Not Otherwise Specified

The reemergence of acute myeloid leukemia not otherwise specified after a period of remission.


Benign neoplasm of cranial nerves

A neoplasm that arises from a cranial nerve and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Refractory Acute Leukemia of Ambiguous Lineage

Acute leukemia of ambiguous lineage that is resistant to treatment.


Childhood Giant Cell Glioblastoma

A giant cell glioblastoma that occurs during childhood.


Syphilitic endocarditis

Endocarditis secondary to syphilis.


Non-Neoplastic Retinal Disorder

A non-neoplastic disorder that affects the retina.


The reemergence of a myelodysplastic/myeloproliferative neoplasm after a period of remission.


Childhood Acute Myeloid Leukemia Not Otherwise Specified

Acute myeloid leukemias that occur in childhood and do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related.  This category includes entities classified according to the French-American-British classification scheme.


Recurrent Astrocytoma, IDH-Mutant, Grade 3

The reemergence of astrocytoma, IDH-mutant, grade 3 after a period of remission.


Cervical Blue Nevus

A nevus that arises from the cervix. It is characterized by the presence of benign, heavily pigmented dendritic melanocytes.


Dyspnea with No Physical Activity Limitation

Dyspnea that does not interfere with their physical activity.


Congenital Disruption

A morphologic defect of an organ, part of an organ, or a larger region of the body that results from the extrinsic breakdown of, or an interference with, an originally normal developmental process.


Transient Organic Mental Disorder

An organic mental disorder that is temporary in nature.


Elevated CA15-3

A laboratory test result indicating the presence of an increased level of the tumor-associated antigen (TAA) CA15-3 in a blood or serum sample.


Atrial Septum Lipomatous Hypertrophy

A condition in which deposits of fat accumulate within the interatrial septum.


EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder

A clonal lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection.


Shared Neoantigen-Positive Malignant Solid Neoplasm

A malignant solid neoplasm that expresses unique tumor-specific neoantigens across a subset of patients.


Radiation-Related Sarcoma

A sarcoma that arises in the bones or soft tissues following exposure to ionizing or non-ionizing radiation.


Recurrent Chronic Myelomonocytic Leukemia

The reemergence of chronic myelomonocytic leukemia after a period of remission.


Appendix Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the appendix. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IA1 Cervical Cancer AJCC v9

Stage IA1 includes: T1a1, N0, M0. T1a1: Tumor with measured stromal invasion equal or less than 3 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Acute Myeloid Leukemia with t(3;12)(q26.2;p13.2); ETV6-MECOM

An acute myeloid leukemia associated with t(3;12)(q26.2;p13.2) resulting in the expression of ETV6-MECOM fusion gene.


Advanced Gastric Neuroendocrine Carcinoma

A gastric neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Connective and Soft Tissue Disorder

A non-neoplastic or neoplastic disorder that affects the connective and soft tissue.


Metastatic Proximal Gastric Adenocarcinoma

A proximal gastric adenocarcinoma that has spread from its original site of growth to another anatomic site.


Skin Basal Cell Carcinoma with Adnexal Differentiation

A basal cell carcinoma of the skin that is characterized by adnexal differentiation.


Central Nervous System Histiocytic and Dendritic Cell Neoplasm

A neoplasm that originates from histiocytes and accessory cells and affects the central nervous system.  It is usually associated with the presence of identical tumors outside the central nervous system.  Representative examples include Langerhans cell histiocytosis, histiocytic sarcoma, and follicular dendritic cell sarcoma.


Metastatic Bladder Nested Urothelial Carcinoma

Bladder nested urothelial carcinoma that has spread to another anatomic site.


Perianal Squamous Intraepithelial Neoplasia

A precancerous neoplastic intraepithelial process involving the squamous epithelium of the perianal skin. Clinically, it usually presents as a white or red area in the perianal skin. Morphologically, it is characterized by full thickness dysplasia of the squamous epithelium and sometimes of the pilosebaceous epithelium. Human papillomavirus DNA sometimes may be identified in the dysplastic epithelium. It may recur after treatment, however only a small percentage of cases progress to squamous cell carcinoma.


Infectious Mediastinitis

An acute or chronic infectious process affecting the mediastinum.


Road Injury

An injury that occurs on a road or motor way.


Elevated Urine Alkaline Phosphatase

An elevated concentration of alkaline phosphatase in the urine.


Infratentorial Glioblastoma

A glioblastoma that occurs in the infratentorial region.


Malignant Lymphoma Follicular, Large Cleaved Cell Type


Juvenile Absence Epilepsy

A subtype of idiopathic generalized epilepsy, whose manifestations occur around puberty, associated with mutation(s) in the EFHC1 gene, encoding EF-hand domain-containing protein 1.


Congenital Abnormalities of Erythrocyte Differentiation or Function

Inherited disorders involving abnormalities of red blood cell function, structure, or production. Some diseases in this group may be associated with bone marrow failure, neutropenia, and/or thrombocytopenia.


Metastatic malignant neoplasm to bone marrow

The spread of a malignant neoplasm from its original site of growth to the bone marrow.


Utricle-Associated Mucosal Gland Hyperplasia

A benign microacinar proliferation occurring exclusively in the area of the utricle.


Acquired Cytomegaloviral Infection

An infection with the Cytomegalovirus that is not present from birth.


Biliary System Disorder

A non-neoplastic or neoplastic disorder that affects the intrahepatic or extrahepatic bile ducts or the gallbladder. Representative examples of non-neoplastic disorders include cholangitis and cholecystitis. Representative examples of neoplastic disorders include extrahepatic bile duct adenoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Increased Concomitant Drug Level

An increase in the level of a concomitant drug.


Adrenal Gland Hyperplasia II

Decreased activity of the enzyme 3-beta-hydroxysteroid dehydrogenase, associated with mutation(s) in the HSD3B2 gene. The lack of activity of this enzyme produces a type of congenital adrenal hyperplasia.


Refractory Gastric Adenocarcinoma

Gastric adenocarcinoma that is resistant to treatment.


Stage IV Vaginal Cancer AJCC v6 and v7

Stage IV includes: IVA: (T4, Any N, M0) and IVB: (Any T, Any N, M1).  T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify tumor as T4).  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 6th and 7th eds.)


Unresectable Extrapulmonary Small Cell Neuroendocrine Carcinoma

Extrapulmonary small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Granuloma of conjunctiva

A granuloma located on the conjunctiva, usually involving the inner surface of the eyelid.


Terminal Hematuria

Gross hematuria that occurs at the end of, or immediately after voiding.


Unresectable Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma that is not amenable to surgical resection.


Prostatic Clear Cell Cribriform Hyperplasia

A rare type of prostatic hyperplasia. It is characterized by hyperplastic glandular cells with clear cytoplasm.


Crushing injury

Traumatic compression of the body or a part of the body.


Metastatic Malignant Mesothelioma

Malignant mesothelioma that has spread from its original site of growth to another anatomic site.


Stage IA Fallopian Tube Cancer AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Fallopian tube cancer with tumor limited to fallopian tube surface; no malignant cells in ascites or peritoneal washings N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Increase in B-type Natriuretic Peptide or N-terminal pro-B-type Natriuretic Peptide

A finding of an increased amount of either B-type natriuretic peptide or N-terminal pro-B-type natriuretic peptide


Increased Drug AUC

Increased area under the plot of plasma concentration of a drug against time after drug administration.


Digestive System Small Cell Neuroendocrine Carcinoma

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant small cells.


Early Localized Lyme Disease

An early stage of Lyme disease that may present within 3-30 days after a tick bite with a red, concentrically-expanding rash (erythema migrans), fatigue, chills, fever, headache, muscle and joint aches, and swollen lymph nodes.


Deficiency of vitamin D3

Abnormally low concentration of vitamin D3 (cholecalciferol) in the blood.


Stage IIIA Anal Cancer AJCC v8

Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


Locally Advanced Small Cell Neuroendocrine Carcinoma

A small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Benign Hair Follicle Neoplasm

A neoplasm that arises from the hair follicle and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Breast Neoplasm

A neoplasm that affects the breast and occurs during childhood.


Nutritional Calcium Deficient Rickets

Nutritional rickets due to dietary deficiency of calcium.


Hypogonadotropic Hypogonadism with Adrenal Hypoplasia Congenita

Hypogonadotropic hypogonadism with congenital adrenal hypoplasia associated with mutation(s) in the NR0B1 gene (on the X chromosome).


Adult Atypical Meningioma

An atypical meningioma that occurs during adulthood.


Ventriculitis

Inflammation of a cerebral ventricle.


IgM Monoclonal Gammopathy

An abnormal laboratory test result indicating the presence of IgM monoclonal immunoglobulin in the blood or urine.


Stage IIIB Esophageal Adenocarcinoma AJCC v7

Stage IIIB includes: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Radiating Chest Pain Along Right Upper Sternal Border

The location of the radiating chest pain is along the right upper sternal border.


Obstructed Megaureter

A megaureter in which there is obstruction to the flow of urine at the ureterovesical junction.


Secondary Graft Failure After Hematopoietic Cell Transplantation

Loss of donor hematopoietic cells following initial engraftment.


Locally Advanced Large Cell Neuroendocrine Carcinoma

A large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Hypoproteinemia

A laboratory test result indicating abnormally low levels of total protein in the serum.


Stage II Centroblastic Follicular Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Extrahepatic bile duct cancer stage II

Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invades the liver, gallbladder, pancreas, and/or unilateral branches or the portal vein (right or left) or hepatic artery (right or left).  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Breast hyperplasia

A general term that refers to hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, usual ductal hyperplasia, columnar cell hyperplasia, and atypical lobular hyperplasia.


Testicular Cystic Trophoblastic Tumor

A rare trophoblastic neoplasm that arises in metastatic sites of testicular mixed germ cell tumors following chemotherapy, or is part of treated or untreated testicular mixed germ cell tumors, or is secondary to either chemotherapy-induced or spontaneous regression of testicular choriocarcinoma. It is characterized by the presence of cysts lined by squamoid trophoblastic cells. The cysts are often compressed surrounded by other germ cell components.


Genitourinary Signs and Symptoms

Patient complaints (symptoms), physical or laboratory findings (signs) related to the genitourinary system.


Nickel Metabolic Disorder

A storage disorder that results from impaired metabolism of nickel.


Recurrent Polymorphous Low Grade Neuroepithelial Tumor of the Young

The reemergence of polymorphous low-grade neuroepithelial tumor of the young after a period of remission.


Malignant neoplasm of bladder recurrent

The reemergence of a malignant bladder neoplasm after a period of remission.


Gastrointestinal carcinoma in situ

An intraepithelial carcinoma arising from any part of the digestive system without evidence of invasion.


Lumbar Meningocele

A congenital abnormality in the lumbar region of the spine in which the meninges protrude through a defect in the spinal column.


Metastatic Extrapulmonary Large Cell Neuroendocrine Carcinoma

Extrapulmonary large cell neuroendocrine carcinoma that has spread to another anatomic site.


Clinical Stage 0 Cutaneous Melanoma AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Unresectable Genitourinary System Carcinoma

Genitourinary system carcinoma that is not amenable to surgical resection.


Primary Cutaneous Mucinous Carcinoma

A rare low-grade carcinoma of the sweat glands. The most common sites are eyelids, scalp, axilla, face and trunk. It is histologically characterized by proliferating ducts until the overproduction of mucin creates islands of tumor cells, essentially floating in mucinous pools (Rosai J. Ackerman's Surgical Pathology).


Unresectable Vulvar Squamous Cell Carcinoma

Vulvar squamous cell carcinoma that is not amenable to surgical resection.


Lupus encephalitis

Encephalitis that is associated with systemic lupus erythematosus.


Childhood depression

Similar to depression in adults, childhood depression is characterized by a prolonged depressed or irritable mood accompanied by a significant loss of interest in activities, changes in appetite or sleep, decreased energy, feelings of worthlessness, and/or recurrent thoughts of death or suicide.


Adult Astroblastoma, MN1-Altered

An astroblastoma, MN1-altered that occurs during adulthood.


Stage IIB Esophageal Carcinoma

Stage IIB includes: For squamous cell carcinoma: (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Congenital spondylolysis

Spondylolysis, the cause of which is present from birth.


Acute Leukemia of Ambiguous Lineage, Not Otherwise Specified

Acute leukemia of ambiguous lineage, expressing combinations of markers that do not allow for its classification as either acute undifferentiated leukemia or mixed phenotype acute leukemia, and definitive classification along a single lineage is difficult. (WHO 2017)


Unresectable Esophageal Carcinoma

A carcinoma that arises from the esophagus and is not amenable to surgical resection.


Papillary mucinous cystadenocarcinoma

An invasive adenocarcinoma characterized by cystic changes, papillary growth pattern, and the presence of malignant glandular cells which contain intracytoplasmic mucin.


Metastatic Primary Malignant Brain Neoplasm

A malignant neoplasm that arises from the brain and has spread from its original site of growth to other sites.


Gastric Hepatoid Adenocarcinoma

A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of large polygonal malignant cells with eosinophilic cytoplasm resembling hepatocytes.


Anal squamous cell carcinoma metastatic

Anal squamous cell carcinoma that has spread from its primary site to another anatomic site.


Recurrent Endometrial Clear Cell Adenocarcinoma

The reemergence of endometrial clear cell adenocarcinoma after a period of remission.


Bone Sarcoma by AJCC v7 Stage

A term that refers to the staging of bone sarcoma, following the rules of the TNM AJCC v7 classification system.


CTRP Clinical Finding

A finding concept that has been requested by CTRP to be used in the disease field for abstraction and search of clinical trials.


Recurrent Large Cell Neuroendocrine Carcinoma

The reemergence of large cell neuroendocrine carcinoma after a period of remission.


Diffuse neurofibroma

A rare neurofibroma with an infiltrative growth pattern.  It involves the skin and subcutaneous tissue and grows in a plaque-like fashion.  Malignant transformation is rare.


Gastric Carcinoma with Lymphoid Stroma

A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of prominent lymphocytic stromal infiltration and poorly formed tubular structures.


A myelodysplastic/myeloproliferative neoplasm that does not meet the criteria of other myelodysplastic/myeloproliferative neoplasms, myelodysplastic syndromes, and myeloproliferative neoplasms. It is associated with cytopenia, blasts less than 20% in bone marrow and peripheral blood, thrombocytosis, and absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions.


Naevus spider acquired

A non-congenital, benign vascular lesion with a central punctum (arteriole) that is surrounded by thin-walled capillaries in a radial pattern. It occurs as the result of the dilatation of pre-existing vessels and is most often an incidental finding. The lesion may also be found in association with hypermetabolic states or chronic disease.


Metastatic Malignant Neoplasm in the Pelvic Cavity

The spread of a malignant neoplasm from a primary site to the pelvic cavity.


Childhood Acute Lymphoblastic Leukemia CNS-Negative Toronto Guidelines v2

No clinical signs of CNS involvement and no blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Refractory Acute Undifferentiated Leukemia

Acute undifferentiated leukemia that does not respond to treatment.


Stage IV Urethral Cancer AJCC v8

Stage IV includes: (T4, N0, M0); (T4, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: For male penile urethra and female urethra: Tumor invades other adjacent organs (e.g., invasion of the bladder wall). For prostatic urethra: Tumor invades other adjacent organs (e.g., extraprostatic invasion of the bladder wall, rectal wall). N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. N2: Multiple regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Skin disorder arising from mental factors

A skin disorder for which mental factors play a causative role.


Aleukemic Myeloid leukemia

Myeloid leukemia presenting with leukemic infiltration of tissues and normal or decreased leukocyte count in the peripheral blood.


Virus-Related Carcinoma

Carcinoma that develops in the context of an individual infected with a virus.


Vulvar Melanocytic Nevus

A benign, atypical, or dysplastic melanocytic nevus that arises from the vulva.


Enterotoxigenic E coli Infection

A pathotype of Escherichia coli, which is a gram-negative bacteria that is transmitted through the fecal-oral route. It has an incubation period of 10-72 hours and a duration of 1-5 days. Symptoms may include acute, occasionally severe diarrhea without fever.


Complete Atrioventricular Canal Defect Balanced

Atrioventricular septal defect in which the atrioventricular junction is shared evenly between the left ventricle and right ventricle.


Benign Liver Non-Epithelial Neoplasm

A non-epithelial neoplasm that arises from the liver and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hemangioma, angiomyolipoma, and solitary fibrous tumor.


Endometrioid intraepithelial neoplasia

A neoplastic clonal expansion of endometrial glands characterized by cytologic changes of the epithelium and the presence of an increased number of endometrial glands. The glands form crowded aggregates with tubular or branching patterns which are cytologically distinct from the background architectural and cytological pattern. It is associated with molecular changes seen in endometrioid endometrial carcinoma, including microsatellite instability, PAX2 inactivation, and PTEN, KRAS, and CTNNB1 gene mutations.


High Leukocyte Count

A higher than average level of leukocytes in a sample.


AIDS-Related Malignant Cervical Neoplasm

A malignant neoplasm that arises from the cervix in a patient with acquired immunodeficiency syndrome. This category includes cervical carcinoma, Kaposi sarcoma, and non-Hodgkin lymphoma.


Pericarditis secondary to uremia

Inflammation of the pericardium associated with chronic kidney failure.


Refractory Chronic Leukemia

Chronic leukemia that is resistant to treatment.


Testicular cancer metastatic

A malignant germ cell tumor that arises from the testis and has spread to another anatomic site.


Non-Functioning Pancreatic Neuroendocrine Tumor G1

A low grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. It is characterized by the absence of a hormone-related clinical syndrome.


Childhood Connective and Soft Tissue Neoplasm

A soft tissue or bone neoplasm that occurs during childhood.


Arterial Thrombosis Related to Vascular Access Complication

The formation of a thrombus in the artery as a direct result of an activity associated with vascular access.


Lugano Classification Stage I Hodgkin Lymphoma AJCC v8

Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Malignant Osteoclastic Giant Cell-Rich Tumor of Bone

A giant cell tumor that arises from the bone and is characterized by the presence of a malignant cellular component.


Refractory Sclerodermatous Graft Versus Host Disease

Sclerodermatous Graft Versus Host Disease that is resistant to treatment.


Infectious Encephalomyelitis

An infectious process that affects the brain and spinal cord tissues. It is usually caused by viruses.


Acral nevus

A melanocytic nevus that arises from the palms, soles, and nails.


Early T Precursor Acute Lymphoblastic Leukemia with BCL11B Rearrangement

Early T precursor acute lymphoblastic leukemia associated with the presence of BCL11B gene rearrangement.


Stage IIA2 Cervical Cancer AJCC v8

Stage IIA2 includes: T2a2, Any N, M0. T2a2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Acute Myeloid Leukemia with STAG2 Mutation

An acute myeloid leukemia associated with STAG2 gene mutation.


Liver Germ Cell Tumor

A benign or malignant extragonadal germ cell tumor that arises from the liver. Representative examples include teratoma and yolk sac tumor.


Loss of INI 1 Protein Expression

An immunohistochemical finding indicating negative staining of tumor cells for INI 1 protein, resulting from the inactivation of the INI 1 tumor suppressor gene.


Refractory Fallopian Tube Mucinous Adenocarcinoma

Fallopian tube mucinous adenocarcinoma that is resistant to treatment.


Borrelia Burgdoferi-Associated Cutaneous Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

Primary cutaneous marginal zone lymphoproliferative disorder that arises from chronically stimulated lymphoid tissue in the skin in response to Borrelia burgdoferi infection.


Indirect Contact Transmission Infection

Infection transmitted by water, food or other means of conveyance.


Interstitial Disease

A disease occurring chiefly in the connective-tissue framework of an organ.


Adolescent Gynecomastia

Gynecomastia that occurs during puberty and is not due to exogenous substances or disease processes.


Anal Canal Cancer by AJCC v6 and v7 Stage

A term that refers to the staging of anal canal cancer according to the American Joint Committee on Cancer, 6th and 7th editions. This staging system applies to carcinomas arising in the anal canal only; melanomas, carcinoid tumors, sarcomas, and perianal tumors are not included. (from AJCC 6th and 7th Eds.)


Chest Pain in Right Fifth Intercostal Space

The location of the chest pain is within the fifth intercostal space on the right side.


Mural Nodule

A solid, sharply demarcated, benign or malignant nodular mass that is attached to the wall of an organ.


Renal lymphocele

Encapsulated collection of lymphatic fluid around a transplanted kidney.


Refractory T Acute Lymphoblastic Leukemia

T-acute lymphoblastic leukemia that does not respond to treatment.


Human Papillomavirus-Related Vaginal Adenocarcinoma

An adenocarcinoma that arises from the vagina and is caused by human papillomavirus infection.


Metastatic Acral Lentiginous Melanoma

Acral lentiginous melanoma that has spread from its original site of growth to another anatomic site.


Unresectable Solid Neoplasm

A solid neoplasm that is not amenable to surgical resection.


Radiation burn

A burn caused by exposure to x-ray, radium, sunlight, atomic or any other type of radiant energy.


Recurrent HIV-Related Lymphoproliferative Disorder

The reemergence of HIV-associated lymphoproliferative disorder after a period of remission.


Testicular Spermatocytic Tumor with Sarcoma

A malignant germ cell tumor that arises from the testis and is characterized by the presence of a spermatocytic tumor component that is contiguous with an undifferentiated or differentiated sarcomatous component.  It usually presents as a slowly growing mass that enlarges very rapidly soon after the initial diagnosis.


Metastatic Gastric Neuroendocrine Carcinoma

A gastric neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site.


Progesterone Receptor Expressing Malignant Neoplasm

A malignant neoplasm that is positive for progesterone receptors.


Myelofibrosis that develops in a patient with history of essential thrombocythemia.


Locally Advanced Digestive System Carcinoma

Digestive system carcinoma that has spread to nearby tissues or lymph nodes.


Metastatic Benign Neoplasm

A very rare benign neoplasm that metastasizes inexplicably. This category includes metastasizing pleomorphic adenoma of the salivary gland and uterine corpus metastasizing leiomyoma.


Refractory Low Grade Fallopian Tube Serous Adenocarcinoma

Low grade fallopian tube serous adenocarcinoma that is resistant to treatment.


Refractory Malignant Urinary System Neoplasm

Malignant urinary system neoplasm that is resistant to treatment.


Signet Ring Melanoma

A rare variant of cutaneous melanoma, characterized by the presence of malignant cells with signet-ring morphology.


Junctional melanocytic nevus of skin

A nevus characterized by the presence of an intraepidermal proliferation of nevus cells. The nevus cells form multiple nests in the dermal-epidermal junction. It presents as a small, slightly raised, pigmented skin lesion.


Mucosal lentiginous melanoma

An acral lentiginous melanoma affecting mucosal surfaces.


Chemically Induced Irreversible Toxicity


Childhood Junctional Nevus

A junctional nevus that occurs during childhood.


Hypoxic-Ischemic Encephalopathy

Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures.


Adult Grade III Meningioma

A grade III meningioma that occurs during adulthood.


Grade I Meningioma

A benign meningioma which may recur in approximately 7-20% of the cases.  This category includes the angiomatous meningioma, fibrous meningioma, lymphoplasmacyte-rich meningioma, meningothelial meningioma, metaplastic meningioma, microcystic meningioma, psammomatous meningioma, secretory meningioma, and transitional meningioma.


Stage II Vulvar Cancer AJCC v8

Stage II includes: T2, N0, M0. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Recurrent Laryngeal Nerve Paralysis

Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis.


Recurrent Central Nervous System Lymphoma

The reemergence of central nervous system lymphoma after a period of remission.


Kidney Paraganglioma

An extremely rare paraganglioma that arises from the renal hilum. Paragangliomas that arise from the perihilar sympathetic ganglia are not included in this category.


Digestive System Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


High Grade Prostatic Intraepithelial Neoplasia, Mucinous Variant

High grade prostatic intraepithelial neoplasia characterized by the presence of masses of mucin within the affected distended glands.


Stage M0 Childhood Ependymoma by Toronto Guidelines v2

No visible disease on imaging (MRI brain and spine) beyond primary site of disease and no tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Malignant neoplasm of stomach recurrent

The reemergence of a malignant neoplasm of the stomach after a period of remission.


Stage I Cervical Cancer AJCC v8

Stage I includes: T1, Any N, M0. T1: Tumor confined to uterus (extension to corpus should be disregarded). M0: No distant metastasis. (AJCC 8th Ed.)


Blastic Granulocytic Sarcoma

A granulocytic sarcoma composed primarily of myeloblasts (WHO 2001).


Childhood NUT Carcinoma

A NUT carcinoma that occurs during childhood.


Lobular Endocervical Glandular Hyperplasia

Lobular proliferations of benign-appearing small to moderate sized endocervical glands in the inner half of the cervical stroma. The glands are lined by columnar epithelial cells which contain pyloric gland-type mucin. There is minimal atypia and mitotic figures are rare. Some cases have been associated with adenocarcinoma in situ/high grade cervical glandular intraepithelial neoplasia and gastric-type adenocarcinomas.


Paratesticular Serous Cystadenoma

A rare serous cystadenoma that arises from the paratesticular structures.


Pocket erosion

Erosion of patient's skin pocket which houses a device.


Clonal Cytopenia with Monocytosis of Undetermined Significance

A myelodysplastic/myeloproliferative neoplasm that fulfills the diagnostic criteria of clonal monocytosis of undetermined significance and is associated with cytopenia.


Stage II Pancreatic Cancer AJCC v8

Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Radiation-Related Osteosarcoma

A high grade osteosarcoma arising in an irradiated bone.


recurrent adult acute myeloid leukemia

The reemergence of acute myeloid leukemia in adults after a period of remission.


No Specific Molecular Profile Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma characterized by the absence of POLE gene mutations, mismatch repair (MMR) deficiency, and p53 gene mutations.


Pancreatic Intraductal Neoplasms

A group of cystic or mass-forming epithelial neoplasms that arise from the exocrine pancreas, exhibit ductal differentiation, and grow mostly within the pancreatic ducts.  This group includes the pancreatic intraductal papillary mucinous neoplasms and the pancreatic intraductal tubulopapillary neoplasms.


Great vessel abnormalities

A congenital vascular abnormality that affects the great vessels and/or aortic arch. Representative examples include double aortic arch, aortic coarctation, and absence of a pulmonary artery.


Stage I Appendix Carcinoma AJCC v7

Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Radiation-Induced Vascular Disease

A vascular disease caused by radiation.


Metastatic Sarcomatoid Urothelial Carcinoma

Sarcomatoid urothelial carcinoma that has spread to another anatomical site.


Second degree perineal laceration

Injury to perineum involving perineal muscles but not involving anal sphincter. (reVITALize)


Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8

Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Gangliocytoma

The reemergence of gangliocytoma after a period of remission.


Low Weight Gain in Pregnancy

In a woman with a normal weight pre-pregnancy body mass index (BMI), i.e. 18.5-24.9, the weight gained during pregnancy does not exceed a total weight gain of 25 lbs. In a woman with an underweight pre-pregnancy body mass index (BMI), i.e. less than 18.5, the weight gained during pregnancy does not exceed a total weight gain of 28 lbs. In a woman with an overweight pre-pregnancy body mass index (BMI), i.e. 25.0-29.9, the weight gained during pregnancy does not exceed a total weight gain of 15 lbs. In a woman with an obese pre-pregnancy body mass index (BMI), i.e. greater than 30, the weight gained during pregnancy does not exceed a total weight gain of 11 lbs. These standards are supported for the whole population irrespective of height, race or ethnicity.


Gallbladder Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The Ki-67 index is higher than 20%.


Blood coagulation disorder due to liver disease

A disorder of blood clotting that is attributable to a deficiency in liver function.


Pathological Gynecomastia

Gynecomastia that is due to exogenous substances or disease processes.


Pedunculated conjunctival papilloma

A papilloma that arises from the conjunctival squamous epithelium. It is associated with human papillomavirus infection.


Benign Intracranial Neoplasm

A neoplasm that involves the intracranial area and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


New Onset Diabetes After Transplant

Development of diabetes after transplant, usually associated with calcineurin inhibitor use.


Localized Prostate Carcinoma

A carcinoma that arises from the prostate and has not spread to other anatomic sites.


Benign Ovarian Partly Luteinized Thecoma


Metastatic Malignant Nongerminomatous Germ Cell Tumor

A malignant nongerminomatous germ cell tumor that has spread from its original site of growth to another anatomic site.


Recurrent Meningioma

The reemergence of a meningioma after a period of remission.


Well Differentiated Malignant Neoplasm

A neoplasm whose histologic characteristics are similar to the tissue from which it arose.


Myelodysplastic syndrome with ring sideroblasts and multilineage dysplasia

A myelodysplastic syndrome with ring sideroblasts and dysplastic changes involving only one myeloid cell lineage in the bone marrow.


Ampulla of Vater Neuroendocrine Neoplasm

A neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Ovarian Leydig Cell Hyperplasia

An increased number of Leydig cells in the hilar region of the ovary. (WHO 2020)


Stage IV Merkel Cell Carcinoma AJCC v7

Stage IV includes: Any T, Any N, M1.  M1: Metastasis beyond regional lymph nodes. (AJCC 7th Ed.)


Stage 0 Anal Cancer AJCC v8

Stage 0 includes: Tis, N0, M0. Tis: High-grade squamous intraepithelial lesion (previously termed carcinoma in situ, Bowen disease, anal intraepithelial neoplasia II-III, high-grade anal intraepithelial neoplasia). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Endometrial Carcinoma

A carcinoma that arises from the endometrium and has metastasized to another anatomic site.


Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma


Digestive System Hodgkin Lymphoma

A Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site.


Refractory Skin Squamous Cell Carcinoma

Skin squamous cell carcinoma that does not respond to treatment.


Simple Hamartoma of the Retinal Pigment Epithelium

A retinal hamartoma that involves only the retinal pigment epithelium. (WHO 2018)


Acute Myeloid Leukemia with del(17p)

Acute myeloid leukemia associated with deletion of the short arm of chromosome 17 [del(17p)].


mCode Non-Neoplastic Disease/Finding

Terminology related to non-neoplastic diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


Extragonadal primary germ cell tumor mixed stage II


Refractory Myxoid Liposarcoma

Myxoid liposarcoma that does not respond to treatment.


Esophageal Adenocarcinoma by AJCC v7 Stage

A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 7th edition.


Subcutaneous Disorder

A disorder of the subcutaneous tissue.


Undersocialized conduct disorder, aggressive type


Locally Advanced Biliary Tract Carcinoma

Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread to nearby tissues or lymph nodes.


Radiating Chest Pain Along Left Midclavicular Line

The location of the radiating chest pain is along the left midclavicular line.


Refractory Endometrial Transitional Cell Carcinoma

Endometrial transitional cell carcinoma that is resistant to treatment.


Recurrent Appendix Carcinoma

The reemergence of appendix carcinoma after a period of remission.


Kidney Schwannoma

A rare schwannoma arising from the kidney.


Childhood Neuroendocrine Neoplasm

A neuroendocrine neoplasm that occurs during childhood.


Congenital complete heart block

A disorder characterized by an electrocardiographic finding of a complete atrioventricular block that manifests during fetal life or soon after birth. It may be isolated or associated with other congenital heart defects. Isolated congenital complete atrioventricular block may be associated with maternal connective tissue disorders.


autosomal dominant dyskeratosis congenita 2

Dyskeratosis congenita caused by mutation(s) in the TERT gene, encoding telomerase reverse transcriptase.


Appendix Neuroendocrine Tumor by AJCC v7 Stage

A term that refers to the staging of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


Lugano Classification Stage IE Childhood Hodgkin Lymphoma AJCC v8

Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Metaplastic meningioma

A WHO grade I meningioma characterized by the presence of a prominent mesenchymal component. The mesenchymal component may be osseous, cartilaginous, myxoid, lipomatous, or a mixture of mesenchymal elements.


Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8

Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Bone Cancer AJCC v7

Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Decreased Carbon Monoxide Diffusing Capacity

A lung function test result in which the lung capacity to absorb carbon monoxide is decreased.


Childhood Blue Nevus

A blue nevus that occurs during childhood.


Joint Tuberculosis

Tuberculosis affecting a joint.


Ureter Cancer by AJCC v7 Stage

A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 7th edition.


Elevated WT1

A finding indicating elevated concentrations of WT1 in a sample.


Epidermal burn of skin

A painful injury to the epidermis due to chemical, friction, radiation or thermal exposure. The affected area appears red and blanches when touched.


Foregut Neuroendocrine Tumor G1

A neuroendocrine tumor grade 1 that arises from the lung, thymus, esophagus, stomach, or duodenum.


Radiating Chest Pain in Left Arm

The location of the radiating chest pain is in the left arm.


Stage IIIA Gallbladder Cancer AJCC v7

Stage IIIA includes: T3, N0, M0. T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Polycythaemia (excl rubra vera)

An increase in the concentration of red blood cells (hemoglobin) that is not caused by polycythemia vera.


Stage IIIC Uterine Corpus Cancer AJCC v8

Stage IIIC includes: IIIC1: T1-T3, N1/N1mi/N1a, M0; IIIC2: T1-T3, N2/N2mi/N2a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2mi: Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


Thrombotic microangiopathy that presents in some patients undergoing hematopoietic stem cell transplantation (HSCT). Though similar in presentation to thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS), transplant-associated thrombotic microangiopathy (TA-TMA) is a distinct disorder. Several risk factors may be associated with TA-TMA, including high-dose chemotherapy, radiation therapy, HLA mismatch, use of calcineurin inhibitors, acute graft-versus-host disease (GVHD), and infections.


Corneal dellen

Corneal thinning just anterior to the limbus secondary to abnormal and/or irregular bulbar conjunctival contour.


Chest Pain in Left Fourth Intercostal Space

The location of the chest pain is within the fourth intercostal space on the left side.


Spindle cell melanoma, type B

A melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli. Representative example is the type B spindle cell uveal melanoma.


Esophageal Adenocarcinoma by AJCC v8 Stage

A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


asymptomatic carrier of alpha-thalassemia

A condition in which a person has reduced protein production from one of the four alpha-globin alleles.


Stage IIIC Cervical Cancer FIGO 2018

Cervical carcinoma with involvement of pelvic and/or para-aortic lymph nodes, irrespective of tumor size and extent (with r and p notations). (FIGO 2018)


Recurrent Severe Aplastic Anemia

The reemergence of severe aplastic anemia after a period of remission.


Recurrent Pancreatic Neuroendocrine Carcinoma

The reemergence of pancreatic neuroendocrine carcinoma after a period of remission.


Stage II Cervical Cancer FIGO 2018

The cervical carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall. (FIGO 2018)


Low Grade Osteosarcoma

An osteosarcoma with low-grade morphological features. This category includes parosteal osteosarcoma and low-grade central osteosarcoma.


Obstructed femoral hernia

The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis.


Tuberculosis disease that is caused by a pre-extensively drug-resistant strain of Mycobacterium tuberculosis.


Vascular Access Device Complications

Difficulties related to an apparatus used to gain access to arteries and veins.


Subpleural Nodule

A nodule that is directly underlying a pleural surface though there may be separation between the nodule margin and pleura.


Non-Neoplastic Pancreatic Disorder

A non-neoplastic disorder that affects the pancreas. Representative examples include pancreatitis and pancreatic insufficiency.


Elevated Blood Pressure Measurement

An abnormally high blood pressure reading.


Sporadic Gastric Diffuse Adenocarcinoma

A sporadic adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of poorly cohesive malignant cells and absence of glandular formations.


Cesarean Scar Pregnancy

An ectopic pregnancy implanted in a previous cesarean (hysterotomy) scar, surrounded by myometrium and connective tissue.


Kir6.2-Associated Diabetes Mellitus

Diabetes mellitus caused by activating mutation(s) in the KCNJ11 gene, encoding the inwardly rectifying Kir6.2 subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the KCNJ11 gene result in hyperinsulinism.


Congenital neuropathy

Neuropathy, the cause of which is present at birth.


Recurrent Ureter Carcinoma

The reemergence of ureter carcinoma after a period of remission


Cystitis Cystica and Glandularis

A reactive inflammatory disorder affecting the bladder.  It is characterized by the development of small cysts in the bladder wall.  The cysts are lined by urothelial cells and metaplastic glandular cells.


Non-Neoplastic Gallbladder Disorder

A non-neoplastic disorder that affects the gallbladder. Representative examples include cholecystitis and adenomyomatosis.


Stage III Low Grade Adult Non-Hodgkin's Lymphoma


True Thymic Hyperplasia

An increase in gross volume and weight of the thymus gland, with maintenance of normal lobular architecture, and preservation of corticomedullary differentiation.


Malignant Peripheral Nerve Sheath Tumor with Mesenchymal Differentiation

A malignant peripheral nerve sheath tumor characterized by the presence of mesenchymal differentiation.  Representative example is the malignant Triton tumor which contains a rhabdomyosarcomatous component.


Non-Inflammatory Female Reproductive System Disorder

A non-inflammatory disorder that affects the female reproductive system.


Bisphosphonate-associated osteonecrosis

Necrosis of the mandible or maxilla in patients receiving intravenous or oral bisphosphonate therapy.  It usually manifests with slow healing or failure to heal of a jaw bone following oral surgery.  In a minority of cases, the necrosis appears spontaneously.  Signs and symptoms include pain, swelling and infection of the affected area.


Benign Extragonadal Germ Cell Tumor

A germ cell tumor that arises from an anatomic site other than the testis or ovary. There is no evidence of atypia or metastases.


Unspecified nonpsychotic mental disorder following organic brain damage

Any mental disorder that occurs secondary to organic brain damage, and that is not associated with psychosis.


Refractory Endometrial Squamous Cell Carcinoma

Endometrial transitional cell carcinoma that is resistant to treatment.


Kidney Mixed Epithelial and Stromal Tumor Family

A family of tumors ranging from predominantly cystic tumors (adult cystic nephromas) to tumors that are variably solid (mixed epithelial and stromal tumors) and contain biphasic epithelial and stromal components with spindle stroma, glands, and cysts. Most of these tumors are benign. (WHO 2016).


A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the skin.


Refractory Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma that is resistant to treatment.


Nodular Sclerosis Classic Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for nodular sclerosis classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Cervical Meningocele

A congenital abnormality in the cervical region of the spine in which the meninges protrude through a defect in the spinal column.


Primary Cold Agglutinin Disease

A clonal B-cell lymphoproliferative disease of the bone marrow that results in autoimmune hemolytic anemia. It is distinct from lymphoplasmacytic lymphoma and IgM monoclonal gammopathy of undetermined significance. It lacks MYD88 gene mutation and is associated with trisomies of chromosomes 3, 12, and 18, and mutations in KMT2D and CARD11 genes.


Recurrent High Grade Endometrioid Adenocarcinoma

The reemergence of high-grade endometrioid adenocarcinoma after a period of remission.


Acute Myeloid Leukemia with t(11;17)(q23;q21)

Acute myeloid leukemia with the variant RARA t(11;17)(q23;q21) and the expression of ZBTB16-RARA fusion protein.  It lacks differentiation response to retinoids treatment.


Pressure Chest Pain

The sensation of chest pain described as an object creating physical force.


Borderline Paratesticular Serous Tumor

A rare, non-invasive, serous cystic tumor that arises from the paratesticular structures. It is characterized by the presence of irregular papillary formations with irregular branching. The papillae are lined by atypical columnar epithelial cells with eosinophilic cytoplasm. Mitoses are rare. Metastases have not been reported.


Adult Nodular Sclerosis Classical Hodgkin Lymphoma

Nodular sclerosis classic Hodgkin lymphoma occurring in adults.


Chronic Myelomonocytic Leukemia-0

A chronic myelomonocytic leukemia characterized by the presence of less than 5 percent blasts in the bone marrow and less than 2 percent blasts in the peripheral blood.


Diffuse malignant lymphoma - large non-cleaved cell

Antiquated term for diffuse non-Hodgkin lymphomas composed of non-cleaved cells.  The vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large B-cell lymphomas).


Trichoblastic carcinoma

A rare biphasic malignant neoplasm with dual differentiation towards the specialized follicular stroma and germinative follicular cells, which can be strikingly atypical. (WHO 2018)


Acute Myeloid Leukemia with t(11;19)(q23.3;p13.1); KMT2A-ELL

An acute myeloid leukemia associated with t(11;19)(q23.3;p13.1) resulting in KMT2A-ELL gene fusion.


Shooting Pain

An intense sensation of discomfort or distress that radiates from one location to another sharply.


Stage IB Pancreatic Cancer AJCC v6 and v7

Stage IB includes: T2, N0, M0. T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Acute Myeloid Leukemia with t(10;11)(q21.3;q23.3); TET1-KMT2A

An acute myeloid leukemia associated with t(10;11)(q21.3;q23.3) resulting in TET1-KMT2A gene fusion.


Pre-Malignant Skin Epithelial Lesion

A term that refers to precancerous epithelial pathologic processes that affect the skin.


Reactive lymphoid hyperplasia of lacrimal gland

A polyclonal proliferation of lymphoid tissue in the lacrimal gland. It usually presents as painless palpable masses leading to globe displacement, decreased motility, diplopia, and ptosis. It has a tendency to involve bilateral lacrimal glands. There is a higher incidence in females and in the setting of autoimmune disease. (WHO 2018)


Sign or Symptom

Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom).


Paraphrenia

A form of schizophrenia characterized by delusions (of persecution or grandeur or jealousy); symptoms may include anger and anxiety and aloofness and doubts about gender identity; unlike other types of schizophrenia the patients are usually presentable and (if delusions are not acted on) may function in an apparently normal manner.


Asymptomatic human immunodeficiency virus infection

An infection caused by human immunodeficiency virus (HIV) that is asymptomatic at the time of testing.


21-hydroxylase deficiency - simple virilizing

A classic form of congenital adrenal hyperplasia that is characterized by severe 21-hydroxylase deficiency, resulting in glucocorticoid and mineralocorticoid deficiency, but without clinically significant salt wasting, and with androgen excess, which causes virilization in female infants.


PERSISTENT MULLERIAN DUCT SYNDROME, TYPE I

Persistent Mullerian duct syndrome due to deficiency of anti-Mullerian hormone.


Recurrent Cervical Adenocarcinoma

The reemergence of cervical adenocarcinoma after a period of remission.


Chronic diastolic heart failure

Chronic congestive heart failure due to a left ventricle which does not fill properly due to decreased compliance though the ejection fraction may be preserved.


Non-Invasive Pancreatic Mucinous-Cystic Neoplasm

A cystic epithelial neoplasm characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and the absence of an invasive carcinomatous component.


Refractory Malignant Lymphoid Neoplasm

A malignant lymphoid neoplasm that does not respond to treatment.


Splenic thrombosis

Formation of a blood clot (thrombus) in the lumen of the splenic vein or splenic artery.


Stage I Osteosarcoma AJCC v7

Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Combined BAP1-Inactivated Nevus

A combined nevus with a spitzoid component and inactivation of BAP1.


Malignant glioma of brain

A grade 3 or 4 glioma that arises from the brain. This category includes anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligoastrocytoma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma (all grade 3 gliomas), and glioblastoma (grade 4 glioma).


Adenocarcinoma in situ in adenomatous polyp

A non-invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp.


Pseudoepitheliomatous hyperplasia

A benign lesion characterized by epidermal and adnexal epithelial hyperplasia.  It is caused by chronic inflammation and infection.  It may be associated with cutaneous neoplasms as well.


Cervical Squamous Intraepithelial Neoplasia 1

Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper two-thirds of the squamous epithelium and mild nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal third of the epithelium.


Cerebral Hemangioblastoma

A hemangioblastoma that arises from the cerebrum.


Hodgkin's disease lymphocyte predominance type stage IV

Stage IV adult Hodgkin disease means there is disseminated (multifocal) involvement of one or more extralymphatic organs, with or without associated lymph node involvement, or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)


Recurrent Intracranial Neoplasm

The reemergence of an intracranial neoplasm after a period of remission.


Stage IIIB Cervical Cancer FIGO 2009

Cervical carcinoma involving the pelvic sidewall. (FIGO 2009)


Non-Neoplastic Eye Disorder

A non-neoplastic disorder that affects the eye.


Esophageal adenocarcinoma that has metastasized to a limited number of sites.


New Onset Atrial Fibrillation Related to COVID-19

Newly occurring atrial fibrillation (AF) in a patient with probable or confirmed acute COVID-19. It is further categorized as first detected AF, paroxysmal AF (self-terminating within seven days of recognized onset), or persistent AF (not self-terminating within seven days).


Blood and lymphatic system disorders

Any deviation from the normal structure or function of the blood or lymphatic system that is manifested by a characteristic set of symptoms and signs.


Metastatic Cervical Carcinoma

A carcinoma of the cervix that has spread to another anatomic site.


Symptom

Subjective evidence of disease perceived by the patient.


Metastatic Bladder Lipid-Rich Urothelial Carcinoma

Bladder lipid-rich urothelial carcinoma that has spread to another anatomic site.


Hodgkin's disease nodular sclerosis stage II supradiaphragmatic


Refractory Adnexal Carcinoma

Adnexal carcinoma that is resistant to treatment.


46,XX/46,XY Ovotesticular Differences of Sex Development

Ovotesticular differences of sex development in individuals with 46,XY/46,XX mosaic karyotype.


Elevated Test Result

A result of a test that is higher than a previous value or a normal range of values.


Acute Pericarditis Related to COVID-19

Acute pericarditis in a patient with probable or confirmed acute COVID-19.


Low Grade Esophageal Glandular Intraepithelial Neoplasia

A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal glandular epithelium.


Cryptococcal gastroenteritis

Gastroenteritis resulting from an infection with cryptosporidium.


Unresectable Gastric Carcinoma

A gastric carcinoma that is not amenable to surgical resection.


Recurrent Fallopian Tube Endometrioid Adenocarcinoma

The reemergence of fallopian tube endometrioid adenocarcinoma after a period of remission.


Gnathoschisis

A congenital abnormality consisting of clefting in the jaw, which results from incomplete fusion of the embryonic mandibular prominence.


Intraoperative Breast Injury

Damage to the breast parenchyma during a surgical procedure.


Non-Neoplastic Bone Disorder

A non-neoplastic disorder that affects the bone or articular cartilage.


Adult Ganglioneuroma

A ganglioneuroma that occurs in adults.


Preexisting Genetic Condition

A condition that existed previously and is genetic in nature.


Nonerosive Arthritis

An inflammation of one or more joints, without loss of articular cartilage or destruction of subchondral bone.


Complete Atrioventricular Septal Defect with Tetralogy of Fallot

A rare congenital heart anomaly in which there is coexistence of tetralogy of Fallot and complete atrioventricular septal defect. The latter is characterized by defects in the atrial and ventricular septa and a common atrioventricular valve.


Gallbladder Adenocarcinoma, Biliary Type

A well or moderately differentiated adenocarcinoma that arises from the gallbladder.  It is the most common type of gallbladder carcinoma and is characterized by the presence of malignant tubular glands.  Intestinal differentiation may be present.


Locally Advanced Unresectable Sarcoma

A sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Recurrent Low Grade Glioma

The reemergence of low grade glioma after a period of remission.


Non-Neoplastic Endocrine Pancreas Disorder

A non-neoplastic disorder that affects the endocrine pancreas.


Estrogen Receptor Status 1+

An immunohistochemical result of 1 for estrogen receptor expression that is considered weak for expression.


Invasive Urothelial Carcinoma with Squamous Differentiation

An invasive urothelial carcinoma that exhibits squamous differentiation.


Chest Pain in Intercostal Space

The location of the chest pain is in the area defined by a superior rib margin and an inferior rib margin.


Chronic Lymphoblastic Lymphoma

This is an invalid term; lymphoblastic lymphomas are not chronic processes, but counterparts of acute lymphoblastic leukemias.


Lip Infection

An acute or chronic infectious process affecting the lips.


Endometrioid Adenocarcinoma of the Urinary Tract

An exceptionally rare endometrioid adenocarcinoma that arises from the urinary tract. It occurs in middle-aged and elderly females. It is associated with genitourinary endometriosis and has been described in the bladder and ureter.


Brain Development Abnormality

A group of congenital or acquired disorders that affect the normal development of the brain.


Invasive Micropapillary Urothelial Carcinoma

Invasive urothelial carcinoma exhibiting micropapillary growth pattern.


Allergic arthritis

Arthritis occurring after the ingestion of allergenic substance(s).


Congenital deformity of hip joint

Any anatomic abnormality of the hip that is present at the time of birth.


Severe Gastrointestinal Tract Acute Graft Versus Host Disease

Graft versus host disease occurring in the gastrointestinal tract and is characterized by complications that may be life-threatening.


Pathologic Stage I Retinoblastoma AJCC v8

Stage I includes: pT1, pT2, pT3, pN0, cM0, Any H. pT1: Intraocular tumor(s) without any local invasion, focal choroidal invasion, or pre-or intralaminar involvement of the optic nerve head. pT2: Intraocular tumor(s) with local invasion. pT3: Intraocular tumor(s) with significant local invasion. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Lacrimal Drainage System Non-Keratinizing Squamous Cell Carcinoma

A squamous cell carcinoma of the lacrimal drainage system characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.


Refractory Urinary System Carcinoma

Urinary system carcinoma that does not respond to treatment.


Recurrent Malignant Male Reproductive System Neoplasm

The reemergence of a malignant male reproductive system neoplasm after a period of remission.


Invasive Bladder Urothelial Carcinoma with Squamous Differentiation

An invasive urothelial carcinoma of the bladder that exhibits squamous differentiation.


Mixed Phenotype Acute Leukemia, T/Megakaryocytic

A very rare mixed phenotype acute leukemia in which the blasts show evidence of T-cell and megakaryocytic lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


Thyroid colloid nodule

A non-cancerous thyroid gland nodule that contains colloid material.


Clinical Stage I Retinoblastoma AJCC v8

Stage I includes: cT1, cT2, cT3, cN0, cM0, Any H. cT1: Intraretinal tumor(s) with subretinal fluid 5 mm or less from the base of any tumor. cT2: Intraocular tumor(s) with retinal detachment, vitreous seeding, or subretinal seeding. cT3: Advanced intraocular tumor(s). cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Papillary serous cystadenoma

A serous benign or low malignant potential cystic epithelial neoplasm characterized by the presence of glandular epithelial cells forming papillary structures.


Steroid Resistant Acute Graft Versus Host Disease

Acute graft versus host disease that is resistant to treatment with steroids.


Fallopian Tube Metaplastic Papillary Tumor

A rare metaplastic lesion that arises from the fallopian tube. It is characterized by the presence of an intraluminal papillary proliferation composed of atypical epithelial cells with abundant eosinophilic cytoplasm. In the vast majority of cases, it is an incidental finding during microscopic examination of a fallopian tube in the postpartum period.


Recurrent Fallopian Tube Carcinoma

The reemergence of fallopian tube carcinoma after a period of remission.


Premalignant Neoplasm

A neoplasm that is composed of dysplastic cells and there is no morphologic evidence of infiltration of the surrounding tissues.


Non-Neoplastic Disorder by Special Category


ROSE Cluster 1

Gene expression cluster 1 as determined by Recognition of Outliers by Sampling Ends (ROSE) in high-risk B-precursor acute lymphoblastic leukemia.


Recurrent Nervous System Neoplasm

The reemergence of a nervous system neoplasm after a period of remission.


Astler-Coller C1 Colon Carcinoma

Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


Refractory T-Cell Large Granular Lymphocyte Leukemia

T-cell large granular lymphocyte leukemia that is resistant to treatment.


Hereditary Malignant Neoplasm

Malignant neoplasms occurring in families at a rate greater than that expected by chance and caused by germline mutations in a specific gene.


Occlusion of inferior vena cava

Blockage of the lumen of the inferior vena cava.


Lugano Classification Advanced Stage Adult Lymphoma AJCC v8

Advanced stage adult lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Monogenic Hyperinsulinism

A genetically heterogenous group of hyperinsulinemic conditions caused by mutation(s) in one of the many genes involved in the regulation of insulin secretion.


Cervix carcinoma recurrent

The reemergence of cervical carcinoma after a period of remission.


Cancer of Urinary Tract

A primary or metastatic malignant neoplasm involving the urinary tract.


Ectopic ureter

A congenital anomaly in which the ureteral orifice drains into an abnormal location.


Advanced Rare Malignant Solid Neoplasm

A rare malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Endometrial Endometrioid Adenocarcinoma with Clear Cell Change

A morphologic variant of endometrioid adenocarcinoma characterized by the presence of large multinucleated clear cells.


Extended Oligoarticular Juvenile Idiopathic Arthritis

Oligoarticular juvenile idiopathic arthritis that eventually involves more than four separate joints.


Staphylococcal arthritis and polyarthritis


Intellectual Disability, Autosomal Dominant 4

An autosomal dominant condition caused by mutation(s) in the CHAMP1 gene, encoding chromosome alignment-maintaining phosphoprotein 1. It is characterized by moderate to severe intellectual disability with poor speech acquisition. Variable dysmorphic features may be present as well.


Neoplasm of lacrimal drainage system

A benign or malignant neoplasm that affects the lacrimal drainage system.


Ovarian Infection

An infectious process affecting the ovary.


Stage II Contiguous Adult Diffuse Mixed Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Invasive Urothelial Carcinoma with Trophoblastic Differentiation

An invasive urothelial carcinoma characterized by the presence of trophoblastic differentiation.


Occupational Malignant Neoplasm

Malignant neoplasm secondary to occupational exposure to carcinogens.


Neuroendocrine cervical carcinoma

A malignant, high grade neuroendocrine neoplasm that arises from the cervix. This category includes small cell and large cell neuroendocrine carcinoma.


Acute Stroke Related to COVID-19

The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system in a patient with probable or confirmed acute COVID-19.


Verrucous carcinoma of the oral cavity stage IV


Childhood Myxopapillary Ependymoma

A myxopapillary ependymoma that occurs during childhood.


Supratentorial Meningioma

A meningioma that affects the supratentorial brain.


Glassy cell carcinoma

A malignant epithelial neoplasm composed of atypical cells with glassy cytoplasm.


Stage IIC Fallopian Tube Cancer AJCC v6 and v7

Stage IIC includes: T2c, N0, M0.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Low grade appendiceal mucinous neoplasm

A well differentiated mucinous neoplasm that arises from the appendix.  It is characterized by slow growth and it is associated with the development of pseudomyxoma peritonei.


Distress

A state of physiological or psychological stress that cannot be compensated for by normal adaptive measures.


Genitourinary System Neoplasm

A benign or malignant neoplasm that affects the genitourinary system.


Urethral Cancer by AJCC v8 Stage

A term that refers to the staging of urethral cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to urothelial (transitional cell), squamous, and glandular carcinomas of the urethra and to urothelial (transitional cell) carcinomas of the prostate and prostatic urethra. It does not apply to squamous cell carcinomas of the penile foreskin (are staged according to the classification for penis), primary urothelial carcinomas of the bladder with transmural involvement of the prostate (are staged according to the classification for urinary bladder), prostatic adenocarcinomas (are staged according to the classification for prostate), mucosal melanomas of the urethra (no AJCC staging system), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs).  (from AJCC 8th Ed.)


Diffuse Non-Pontine Midline Glioma

A diffuse glioma that arises from the midline structures of the central nervous system, other than the pons.