Small Intestinal Follicular Lymphoma

A follicular lymphoma that arises from the small intestine.  It most often affects the duodenum.


Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2 Stage

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A term that refers to the staging of childhood non-Hodgkin lymphoma according to the Toronto childhood cancer staging guidelines v2.


Nodular Lymphocyte Predominant Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for nodular lymphocyte predominant B-cell lymphoma based on the Ann Arbor classification criteria.


Breast T-Cell Non-Hodgkin Lymphoma

A T-cell non-Hodgkin lymphoma that arises from the breast as a primary tumor.  Primary T-cell non-Hodgkin lymphomas of the breast are rare.


Stage IB Mycosis Fungoides AJCC v7

Stage IB includes: T2, N0, M0, B0-1. T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Acute Adult T-Cell Leukemia/Lymphoma

The most common variant of adult T-cell leukemia/lymphoma.  It is characterized by systemic disease with a leukemic phase, generalized lymphadenopathy, and skin lesions.  Hypercalcemia is commonly seen.


Ann Arbor Stage II Adult Contiguous Immunoblastic Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Diffuse large B-cell lymphoma activated B-cell type that is resistant to treatment.


Angiocentric lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Recurrent B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma

The reemergence of gray-zone lymphoma after a period of remission.


Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type

The reemergence of diffuse large B-cell lymphoma activated B-cell type after a period of remission.


adult nodular lymphocyte predominant Hodgkin lymphoma

A nodular lymphocyte predominant Hodgkin lymphoma occurring in adults.


Lacrimal Drainage System Mucosa-Associated Lymphoid Tissue Lymphoma

A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal sac.


Non-Hodgkin Breast Lymphoma

A non-Hodgkin lymphoma that arises from the breast.  There is no history of extramammary breast non-Hodgkin lymphoma and ipsilateral axillary lymph node involvement does not exclude the diagnosis of primary breast non-Hodgkin lymphoma.  Most patients present with a painless breast lump.  The vast majority of cases are B-cell non-Hodgkin lymphomas.  Diffuse large B-cell lymphoma, follicular lymphoma, and extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue are the most common types of primary non-Hodgkin lymphoma of the breast.


Common Variant Anaplastic Large Cell Lymphoma

An anaplastic large cell lymphoma, characterized by CD30 positive lymphoid cells.


Mycosis fungoides/Sezary syndrome stage II

Stage II includes: IIA (T1-2, N1-2, M0, B0-1); IIB (T3, N0-2, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Diffusion Restriction

A radiologic finding seen as high-signal intensity on diffusion weighted imaging with corresponding reduced apparent diffusion coefficient (ADC) values. ADC is a measurement of the diffusion of water molecules in a given tissue.


Parotid Gland Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the parotid gland.  Representative examples include mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


Waldenstrom macroglobulinemia with serum IgM monoclonal protein equal or more than 3 g/dL and/or at least 10% bone marrow lymphoplasmacytic infiltration but no evidence of constitutional symptoms, symptomatic anemia, or hyperviscosity. (Blood 2008, 112:2709)


lymphoblastic lymphoma

A lymphoma composed of immature small to medium-sized precursor lymphoid cells (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma.


Adult EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

An EBV-positive diffuse large B-cell lymphoma, not otherwise specified, that occurs in adults. It was originally described in patients older than 50 years, but it has been increasingly recognized in younger patients.


Recurrent High Grade B-Cell Lymphoma

The reemergence of high-grade B-cell lymphoma after a period of remission.


BN2 diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma that is categorized as BN2 with high probability by the LymphGen algorithm. This is based on a combination of genetic features and BN2 DLBCLs often, but do not always, have a translocation involving the BCL6 locus and/or some combination of mutations affecting NOTCH2, TNFAIP3, BCL10 and UBE2A. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting CD70, which can be coding or non-coding.


Follicular Lymphoma by Ann Arbor Stage

An anatomic stage for follicular lymphoma based on the Ann Arbor classification criteria.


Stage III Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Extranodal marginal zone B-cell lymphoma (MALT type) stage II

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage II disease.


Extranodal marginal zone B-cell lymphoma (MALT type) refractory

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that is resistant to treatment.


EBV-Related Burkitt Lymphoma

Burkitt lymphoma that is caused by Epstein-Barr virus infection.


Refractory Transformed Non-Hodgkin Lymphoma

An indolent non-Hodgkin lymphoma which has undergone histologic transformation to an aggressive non-Hodgkin lymphoma and has become resistant to treatment.


Follicular lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Diffuse Large B-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for diffuse large B-cell lymphoma based on the Ann Arbor classification criteria.


Stage I Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

Involvement of a single tumor mass or nodal area, excluding the abdomen and mediastinum. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Ann Arbor Stage I Supradiaphragmatic Nodular Lymphocyte Predominant Hodgkin Lymphoma


Burkitt Lymphoma Post-Transplant Lymphoproliferative Disorder

A Burkitt lymphoma that arises in a patient with a history of organ transplantation.


Angioimmunoblastic T-cell lymphoma stage II


folliculotropic mycosis fungoides

Folliculotropic mycosis fungoides is a rare variant of mycosis fungoides (MF), a form of cutaneous T-cell lymphoma, and is characterized by the presence of folliculotropic infiltrates in patch-plaque lesions usually involving the head and neck area.


Refractory Plasmablastic Lymphoma

Plasmablastic lymphoma that is resistant to treatment.


Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

The reemergence of transformed follicular lymphoma to diffuse large B-cell lymphoma after a period of remission.


Nasopharyngeal Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the nasopharynx.


Ann Arbor Stage II Contiguous Adult Aggressive Non-Hodgkin Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


AIDS-Related Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

A diffuse large B-cell lymphoma that arises from the central nervous system in AIDS patients.


ALK-negative anaplastic large cell lymphoma (ALK- ALCL) is a type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the lack of expression of a protein called anaplastic lymphoma kinase (ALK).


Mature T- and NK-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for mature T- and NK-cell non-Hodgkin lymphomas based on the Ann Arbor classification criteria.


Mantle Cell Lymphoma by Ann Arbor Stage

An anatomic stage for mantle cell lymphoma based on the Ann Arbor classification criteria.


Angioimmunoblastic T-cell lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Primary Uveal Non-Hodgkin Lymphoma

An indolent, low-grade B-cell non-Hodgkin lymphoma that arises from the choroid, iris, or ciliary body. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Lymphoid follicles with germinal centers may be present. In the past these tumors were termed 'reactive lymphoid hyperplasia'. Now they are considered low-grade B-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


Stage III Indolent Adult Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Centroblastic lymphoma recurrent

The reemergence of centroblastic lymphoma after a period of remission.


Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IB includes: T2, N0, M0, B0,1. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Ann Arbor Stage IV Mature T- and NK-Cell Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Mycosis fungoides refractory

Mycosis fungoides resistant to treatment.


Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IIB includes: T3, N0-2, M0, B0-1.  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


marginal zone lymphoma

A usually indolent mature B-cell lymphoma, arising from the marginal zone of lymphoid tissues. It is characterized by the presence of small to medium sized atypical lymphocytes. It comprises three entities, according to the anatomic sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph nodes without evidence of extranodal disease; and splenic marginal zone B-cell lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood.


Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

A T-cell peripheral lymphoma affecting multiple anatomic sites. It is composed of usually large, pleomorphic, CD30 positive T-lymphocytes with abundant cytoplasm. It is characterized by the presence of a translocation involving the ALK gene and expression of ALK fusion protein.


Nodal Peripheral T-Cell Lymphoma of T Follicular Helper Cell Origin

A group of node-based peripheral T-cell lymphomas with phenotypic features of T follicular helper (TFH) cells. This category includes the following: follicular helper T-cell lymphoma, angioimmunoblastic-type; follicular helper T-cell lymphoma, follicular-type; and follicular helper T-cell lymphoma, not otherwise specified.


Recurrent Nodal Peripheral T-Cell Lymphoma with TFH Phenotype

The reemergence of follicular helper T-cell lymphoma after a period of remission.


splenic mantle cell lymphoma

A mantle cell lymphoma occurring in the spleen.


Recurrent Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

The reemergence of diffuse large B-cell lymphoma that resulted from the transformation of marginal zone lymphoma, after a period of remission.


Recurrent Burkitt Lymphoma

The reemergence of Burkitt lymphoma after a period of remission.


Prostate Diffuse Large B-Cell Lymphoma

A rare diffuse large B-cell lymphoma that arises from the prostate gland.


Monomorphic epitheliotropic intestinal T-cell lymphoma

A mature T-cell and NK-cell non-Hodgkin lymphoma of intraepithelial T-lymphocytes. It usually arises from the small intestine. A minority of cases arise from the large intestine or the stomach. It is characterized by the presence of a monomorphic cellular infiltrate of small to medium-sized T-lymphocytes that are cytotoxic and express CD56. It is not associated with celiac disease.


large B-cell diffuse lymphoma of salivary gland

A diffuse large B-cell lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland.


Ann Arbor Stage II Grade 1 Follicular Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Childhood Anaplastic Large Cell Lymphoma

An anaplastic large cell lymphoma that occurs during childhood.


Anaplastic Lymphoma Post-Transplant Lymphoproliferative Disorder

An anaplastic lymphoma that arises in a patient with a history of organ transplantation.


Stage IV Indolent Adult Non-Hodgkin Lymphoma


enteropathy-associated T-cell lymphoma

An uncommon mature T-cell lymphoma of intraepithelial lymphocytes. It usually arises from the small intestine, most commonly the jejunum or ileum. Other less frequent primary anatomic sites include the duodenum, stomach, colon, or outside the gastrointestinal tract. It is seen with increased frequency in regions with a high prevalence of celiac disease.


Ann Arbor Stage III Grade 3 Follicular Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


T-cell lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


Refractory Primary Cutaneous Anaplastic Large Cell Lymphoma

Primary cutaneous anaplastic large cell lymphoma that is resistant to treatment.


nodular lymphocyte predominant Hodgkin lymphoma

A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in nearly all instances. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage I or II). (WHO 2008)


Sezary syndrome refractory

Sezary syndrome that is resistant to treatment.


follicular lymphoma of spleen

A follicular lymphoma occurring in the spleen.


Refractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

Transformed follicular lymphoma to diffuse large B-cell lymphoma that is resistant to treatment.


central nervous system anaplastic large cell lymphoma

An anaplastic large cell lymphoma that affects the brain, meninges, or spinal cord.


Ann Arbor Stage II Grade 1 Contiguous Follicular Lymphoma


Lacrimal Gland Mucosa-Associated Lymphoid Tissue Lymphoma

A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal gland.


Hodgkin-Like Adult T-Cell Leukemia/Lymphoma

A rare morphologic variant of adult T-cell leukemia/lymphoma characterized by the presence of Hodgkin-like and Reed-Sternberg-like cells.


Angioimmunoblastic T-Cell Lymphoma by Ann Arbor Stage

An anatomic stage for follicular helper T-cell lymphoma, angioimmunoblastic-type  based on the Ann Arbor classification criteria.


Triple hit lymphoma

High-grade B-cell lymphoma characterized by the abnormal rearrangement of MYC gene, BCL2 gene, and BCL6 gene. Patients with this type of lymphoma usually respond poorly to standard treatments and have a poor prognosis.


Waldenstrom macroglobulinemia that does not respond to treatment.


Ann Arbor Stage III Aggressive Adult Non-Hodgkin Lymphoma


Blastoid Variant Mantle Cell Lymphoma

An aggressive mantle cell lymphoma characterized by the presence of neoplastic B-lymphocytes resembling lymphoblasts.


thyroid gland diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma primarily involving the thyroid gland.


Ann Arbor Stage I Grade 2 Follicular Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Precursor B-lymphoblastic lymphoma stage III


BCL2-R-Negative, CD23-Positive Follicle Center Lymphoma

Follicular lymphoma characterized by the absence of BCL2 rearrangement and the presence of CD23-positive neoplastic cells. It is associated with STAT6 mutations. It presents with low-stage disease, typically in the inguinal region, and often has a predominant diffuse growth pattern.


Ann Arbor Stage II Grade 2 Contiguous Follicular Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


localized pagetoid reticulosis

A variant of mycosis fungoides, characterized by an exclusively intraepidermal atypical (cerebriform) lymphocytic infiltrate. Patients present with a localized psoriasiform or hyperkeratotic patch or plaque, usually in the extremities. Extracutaneous dissemination of the disease has never been reported.


nodal marginal zone B-cell lymphoma

Nodal marginal zone B-cell lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma, characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement of the lymph nodes, sometimes the bone marrow, and rarely the blood. Clinically it presents with disseminated peripheral, abdominal and/or thoracic lymphadenopathy. Cytopenia and bulky tumors (greater than 5 cm) are rare. Association with Hepatitis C virus and chronic inflammation has been reported.


Refractory Systemic Anaplastic Large Cell Lymphoma

Systemic anaplastic large cell lymphoma that does not respond to treatment.


Primary Vitreoretinal Non-Hodgkin Lymphoma

An uncommon and potentially fatal intraocular non-Hodgkin lymphoma that involves the uvea, retina, vitreous body, and optic nerve. It is a subset of primary central nervous system non-Hodgkin lymphoma. The majority of cases are diffuse large B-cell lymphomas.


grade 3B follicular lymphoma

A grade 3 follicular lymphoma composed of solid sheets of centroblasts.


Recurrent Hepatosplenic T-Cell Lymphoma

The reemergence of hepatosplenic T-cell lymphoma after a period of remission.


Grade III Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis characterized by the presence of aggregates of neoplastic large B-lymphocytes, usually admixed with pleomorphic and Hodgkin-like cells, in a background of chronic inflammation.  Necrotic changes are present and are usually extensive.  Grade III lymphomatoid granulomatosis should be approached clinically as a subtype of diffuse large B-cell lymphoma.


Adult Systemic Anaplastic Large Cell Lymphoma

An anaplastic large cell lymphoma affecting multiple anatomic sites and occurring in adults.


Predominantly Diffuse Follicular Lymphoma with 1p36 Deletion

A predominantly diffuse, low-grade follicular lymphoma. It often presents as a large localized inguinal mass, lacks BCL2 rearrangement, and is associated with 1p36 deletion.


Colon Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that arises from the colon.  It is the most frequent type of lymphoma found in the colon.


Mycosis fungoides stage I

Stage I includes: IA (T1, N0, M0, B0-1); IB (T2, N0, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Stage III Childhood Anaplastic Large Cell Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Nodal marginal zone B-cell lymphoma stage II


Childhood Immunoblastic Lymphoma

An immunoblastic lymphoma (a variant of diffuse large B-cell lymphoma) occurring in children.


Prostate Mantle Cell Lymphoma

A rare mantle cell lymphoma that arises from the prostate gland.


The reemergence of lymphoplasmacytic lymphoma after a period of remission.


Refractory Transformed T-cell Non-Hodgkin Lymphoma

An indolent T-cell non-Hodgkin lymphoma which has undergone histologic transformation to an aggressive T-cell non-Hodgkin lymphoma and has become resistant to treatment.


Non-Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for non-Hodgkin lymphomas based on the Ann Arbor classification criteria.


Stage IVB Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IVB includes: T1-4, N0-3, M1, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified).  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.  (AJCC 7th ed.)


Lymphoplasmacytoid lymphoma/immunocytoma stage III


Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

Mature T-cell and NK-cell non-Hodgkin lymphoma that is resistant to treatment.


AIDS-Related Non-Hodgkin Lymphoma of the Cervix

A non-Hodgkin lymphoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


Liver Mucosa-Associated Lymphoid Tissue Lymphoma

A rare mucosa-associated lymphoid tissue lymphoma that arises from the liver.  It is characterized by the presence of centrocyte-like cells surrounding germinal centers.  Lymphoepithelial lesions involving the bile duct epithelium may also be present.


Cyclin D1-Positive Mantle Cell Lymphoma

A molecular subtype of mantle cell lymphoma characterized by the presence of cyclin D1 expression and/or CCND1 rearrangement..


Mature B-Cell Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that originates from mature B lymphocytes. Representative examples include diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, and small lymphocytic lymphoma.


small cell variant anaplastic large cell lymphoma

A histologic variant of anaplastic large cell lymphoma characterized by the presence of a predominant population of small to medium size malignant cells with irregular nuclei.


Ann Arbor Stage II Non-Contiguous Mantle Cell Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Ann Arbor Stage I Aggressive Adult Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Refractory B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma

Gray-zone lymphoma that is resistant to treatment.


Anaplastic large cell lymphoma T- and null-cell types refractory

Anaplastic large cell lymphoma resistant to treatment.


Mediastinal Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma arising from the mediastinum.


Chlamydia Psittaci-Associated Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma

Mucosa-associated lymphoid tissue lymphoma that arises from the ocular adnexa and caused by stimulation of lymphoid tissue due to Chlamydia psittaci bacterial infection.


Colorectal Burkitt Lymphoma

A rare Burkitt lymphoma that arises from the colon or rectum.


Recurrent Systemic Anaplastic Large Cell Lymphoma

The reemergence of systemic anaplastic large cell lymphoma after a period of remission.


Stage IV Diffuse Large B-Cell Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Colon Mantle Cell Lymphoma

A mantle cell lymphoma that arises from the colon.  It often presents as a polypoid lesion.


Smoldering Adult T-Cell Leukemia/Lymphoma

An adult T-cell leukemia/lymphoma characterized by less than 5% neoplastic lymphocytes in the peripheral blood, absence of lymphadenopathy and hypercalcemia, and occasional skin or pulmonary lesions.


follicular malignant lymphoma of breast

A follicular lymphoma that arises from the breast as a primary tumor.


biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2).


cellular response to interleukin-9

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus.


Charcot-Marie-Tooth disease X-linked recessive 3

X-linked Charcot-Marie-Tooth disease type 3 is a rare, genetic, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the childhood- to adolescent-onset of progressive, distal muscle weakness and atrophy (beginning in the lower extremities and then affecting the upper extremities), as well as distal, pansensory loss in the upper and lower extremities, pes cavus, and absent or reduced distal tendon reflexes. Pain and paresthesia are frequently the initial sensory symptoms. Spastic paraparesis (manifested by clasp-knife sign, hyperactive deep-tendon reflexes, and Babinski sign) has also been reported.


Charcot-Marie-Tooth disease type X

A subtype of Charcot-Marie-Tooth disease with genetic defects on the X chromosome.


Charcot-Marie-Tooth disease X-linked recessive 4

X-linked Charcot-Marie-Tooth disease type 4 is a rare, genetic, axonal, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the neonatal- to early childhood-onset of severe, slowly progressive, distal muscle weakness and atrophy (in particular of the peroneal group), as well as sensory impairment (with the lower extremities being more affected than the upper extremities), pes cavus, areflexia and hammertoes. Sensorineural hearing loss and cognitive impairment may also be associated. Females are asymptomatic and do not display the phenotype.


Charcot-Marie-Tooth disease X-linked recessive 5

X-linked Charcot-Marie-Tooth disease type 5 is a rare, genetic, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the infancy- to childhood-onset of: 1) progressive distal muscle weakness and atrophy (first appearing and more prominent in the lower extremities than the upper) which usually manifests with foot drop and gait disturbance, 2) bilateral, profound, prelingual sensorineural hearing loss and 3) progressive optic neuropathy. Females are asymptomatic and do not display the phenotype.


Charcot-Marie-Tooth disease X-linked dominant 1

Charcot-Marie-Tooth neuropathy that is inherited in an X-linked manner, and is associated with mutation(s) in the GJB1 gene, encoding gap junction beta-1 protein. The condition is characterized by moderate to severe motor and sensory neuropathy in males, and mild to no symptoms in females.


Charcot-Marie-Tooth disease X-linked recessive 2

X-linked Charcot-Marie-Tooth disease type 2 is a rare, genetic, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the infantile- to childhood-onset of progressive, distal muscle weakness and atrophy (more prominent in the lower extremities than in the upper extremities), pes cavus, and absent tendon reflexes. Sensory impairment and intellectual disability has been reported in some individuals.


Charcot-Marie-Tooth disease X-linked dominant 6

X-linked Charcot-Marie-Tooth disease type 6 is a rare, genetic, principally axonal, peripheral sensorimotor neuropathy characterized by an X-linked dominant inheritance pattern and the childhood-onset of slowly progressive, moderate to severe, distal muscle weakness and atrophy of the lower extremities, as well as distal, panmodal sensory abnormalities, bilateral foot deformities (pes cavus, clawed toes), absent ankle reflexes and gait abnormalities (steppage gait). Females are usually asymptomatic or only present mild manifestations (mild postural hand tremor, mild wasting of hand intrinsic muscles).


statin (semi-synthetic)

A statin that is derived from a naturally occurring statin by partial chemical synthesis.


Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP.


hippocampal sclerosis of aging

Age-related neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus


selenocystathione synthase activity

Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine.


Benign cyst of ovary

A non-malignant ovarian cyst.


Large Solitary Luteinized Follicle Cyst of Ovary

A large, unilateral, solitary ovarian cyst lined by luteinized cells, occurring during pregnancy or puerperium. (WHO 2020)


Complex ovarian cyst

A cystic lesion that arises from the ovary. It is characterized by the presence of cystic spaces that contain fluid and a solid tissue component.


Unilocular Ovarian Cyst

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

An ovarian cyst that has a single compartment.


Follicular cyst of ovary

A benign ovarian cyst that develops from a persistent, unruptured Graafian follicle, which grows larger than three centimeters.


Autonomous Ovarian Follicular Cyst

A cyst arising from an ovarian follicle that produces hormones independent of gonadotropin stimulation.


Functional cyst of ovary

A benign ovarian cyst that develops and regresses during the menstrual cycle as part of normal ovarian function.


positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore

Any process that activates or increases the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore.


saturated organic heteromonocyclic parent


specification of metanephric connecting tubule identity

The process in which the connecting tubule of the metanephric nephron acquires its identity.


L-cysteine catabolic process to hypotaurine

The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine.


cellular detoxification of acetone

Any process carried out at the cellular level that reduces or removes the toxicity of acetone. These may include chemical modification, for example to methylglyoxal.


FIGO Stage IIIB Ovarian Cancer

Ovarian cancer with macroscopic, extrapelvic, peritoneal metastasis equal or less than 2 cm +/- positive retroperitoneal lymph nodes. Includes extension to capsule of liver/spleen. (FIGO, 2014)


positive regulation of lysosomal membrane permeability

Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.


regulation of lysosomal membrane permeability

Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.


negative regulation of lysosomal membrane permeability

Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.


positive regulation of butyryl-CoA catabolic process to butanol

Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butanol.


regulation of butyryl-CoA catabolic process to butanol

Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butanol.


negative regulation of butyryl-CoA catabolic process to butanol

Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butanol.


Recurrent T Acute Lymphoblastic Leukemia

The reemergence of T-acute lymphoblastic leukemia after a period of remission.


Recurrent Childhood T Acute Lymphoblastic Leukemia

The reemergence of T-acute lymphoblastic leukemia in childhood after a period of remission.


urate catabolic process

The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine.


positive regulation of peripheral T cell tolerance induction

Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction.


regulation of peripheral T cell tolerance induction

Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction.


regulation of T cell tolerance induction to tumor cell

Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell.


negative regulation of T cell tolerance induction to tumor cell

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell.


positive regulation of T cell tolerance induction to tumor cell

Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell.


negative regulation of peripheral T cell tolerance induction

Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction.


non-motile cilium membrane

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The portion of the plasma membrane surrounding a non-motile cilium.


cone photoreceptor disc membrane

Stack of disc membranes located inside a cone photoreceptor outer segment, and containing densely packed molecules of opsin photoreceptor proteins that traverse the lipid bilayer. Cone disc membranes arise as evaginations of the ciliary membrane during the development of the cone outer segment and remain contiguous with the ciliary membrane.


negative regulation of asperfuranone biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of asperfuranone biosynthetic process.


Hailey-Hailey disease

Benign chronic familial pemphigus of Hailey-Hailey is characterized by rhagades mostly located in the armpits, inguinal and perineal folds (scrotum, vulva).


A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane.


maintenance of postsynaptic specialization structure

A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.


maintenance of postsynaptic density structure

A process which maintains the organization and the arrangement of proteins in the presynaptic density.


postsynaptic specialization assembly

The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane.


Catalysis of the reaction: genistin + UDP-alpha-D-glucose = genistin 7-gentiobioside + UDP + H+.


abducens nerve structural organization

The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.


FLVCR1-related retinopathy with or without ataxia

A disorder characterized by retinopathy with ataxia in most patients, caused by biallelic variants in the FLVCR1 gene.


posterior column ataxia-retinitis pigmentosa syndrome

Posterior column ataxia - retinitis pigmentosa is characterized by the association of progressive sensory ataxia and retinitis pigmentosa.


single cytosine insertion binding

Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine.


Ebola hemorrhagic fever

A viral hemorrhagic fever that is caused by the Ebola virus, which is transmitted by contact with infected animals or humans; it is characterized by high fever, unexplained bleeding, and a high mortality rate.


Mononegavirales infectious disease

Infections with viruses of the order mononegavirales. The concept includes filoviridae infections; paramyxoviridae infections; and rhabdoviridae infections.


mumps infectious disease

A contagious viral infection caused by the mumps virus. Symptoms include swollen and tender parotid glands, fever, muscle aches and fatigue. Due to vaccination programs, mumps has become a rare disease.


parainfluenza virus type 2 infectious disease

A disease caused by infection with parainfluenza virus type 2.


fetal parainfluenza virus type 3 syndrome

A syndrome caused by HPIV-3.


parainfluenza virus type 3 infectious disease

Parainfluenza virus type 3 is one of a group of common viruses known as human parainfluenza viruses (HPIV) that cause a variety of respiratory illnesses. Symptoms usually develop between 2 and 7 days from the time of exposure and typically resolve in 7-10 days. Symptoms may include fever, runny nose, and cough. HPIV-3 can also cause bronchiolitis, bronchitis, and pneumonia. Infants and young children are particularly susceptible to HPIV-3 infections, though older adults and those with a weakened immune system are also at risk for complications. HPIVs are usually spread from an infected person to others through coughing, sneezing, and/or touching. There is currently no vaccine to protect against parainfluenza virus infections. Most HPIV infections resolve on their own and do not require special treatment, though medical intervention may be necessary for severe breathing problems. Most adults have antibodies against parainfluenza but can get repeat infections.


henipavirus infectious disease

Infections with viruses of the genus henipavirus, family paramyxoviridae.


Rhabdoviridae infectious disease

Virus diseases caused by rhabdoviridae. Important infections include rabies; ephemeral fever; and vesicular stomatitis.


borna disease

An encephalomyelitis of horses, sheep and cattle caused by borna disease virus.


Marburg hemorrhagic fever

Marburg hemorrhagic fever (MHF), caused by Marburg virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure.


morbillivirus infectious disease

Infections with viruses of the genus morbillivirus, family paramyxoviridae. Infections mainly cause acute disease in their hosts, although in some cases infection is persistent and leads to degenerative conditions.


respirovirus infectious disease

Infections with viruses of the genus respirovirus, family paramyxoviridae. Host cell infection occurs by adsorption, via hemagglutinin, to the cell surface.


Paramyxoviridae infectious disease

Infections with viruses of the family paramyxoviridae. This includes morbillivirus infections; respirovirus infections; pneumovirus infections; henipavirus infections; avulavirus infections; and rubulavirus infections.


Filoviridae infectious disease

Infections with viruses of the family filoviridae. The infections in humans consist of a variety of clinically similar viral hemorrhagic fevers but the natural reservoir host is unknown.


parainfluenza virus type 4 infectious disease

A disease caused by infection with parainfluenza virus type 4.


Nipah virus disease

Nipah virus disease, caused by the Nipah virus, is a recently discovered zoonotic disease characterized by fever, constitutional symptoms and encephalitis, sometimes accompanied by respiratory illness.


parainfluenza virus type 1 infectious disease

A disease caused by infection with parainfluenza virus type 1.


parainfluenza infectious disease

A disease caused by infection with parainfluenza virus. There are four serotypes which cause respiratory illnesses in children and adults.


Avulavirus infectious disease

Infections with viruses of the genus avulavirus, family paramyxoviridae. This includes newcastle disease and other infections of domestic fowl.


NAD-independent histone deacetylase activity

Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone.


adult central nervous system choriocarcinoma

A choriocarcinoma of the central nervous system that occurs in an adult.


negative regulation of lung goblet cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of lung goblet cell differentiation.


Ciliary Body Adenoma

A benign neoplasm of the pigmented ciliary epithelium (pigmented epithelial adenoma) and/ or the non-pigmented ciliary epithelium (non-pigmented epithelial adenoma). (WHO 2018)


positive regulation of exo-alpha-sialidase activity

Any process that activates or increases the frequency, rate or extent of exo-alpha-sialidase activity.


positive regulation of protein localization to medial cortex

Any process that activates or increases the frequency, rate or extent of protein localization to the medial cortex.


regulation of protein localization to cell division site

Any process that modulates the frequency, rate or extent of protein localization to cell division site.


regulation of protein localization to cell division site involved in cell separation after cytokinesis

Any regulation of protein localization to cell division site that is involved in cell separation after cytokinesis.


positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly

Any process that activates or increases the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly.


negative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly.


positive regulation of protein localization to medial cortical node

Any process that activates or increases the frequency, rate or extent of protein localization to a medial cortical node.


regulation of protein localization to cell division site involved in cytokinesis

Any regulation of protein localization to cell division site that is involved in cytokinesis.


regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly

Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly.


regulation of protein localization to medial cortical node

Any process that modulates the frequency, rate or extent of protein localization to a medial cortical node.


negative regulation of protein localization to medial cortex

Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex.


regulation of protein localization to medial cortex

Any process that regulates the localization of a protein to the medial cortex.


Bone Marrow, Rib

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Bone marrow in the rib.


Bone Marrow, Femur

Bone marrow in the femoral bone.


Bone Marrow, Scapula

Bone marrow in the scapula.


Bone Marrow, Tibia

Bone marrow in the tibia bone.


Bone Marrow, Vertebral

Bone marrow in a vertebral bone.


Bone Marrow, Humerus

Bone marrow in the humerus bone.


Bone Marrow, Sternum

Bone marrow in the sternum.


Smouldering systemic mastocytosis

Smouldering systemic mastocytosis is a type of systemic mastocytosis (SM). This clonal hematologic disease, with a slow progression, results in an accumulation of neoplastic mast cells in the visceral organs over time and patients present with splenomegaly, hypercellular marrow and, in some cases, urticaria pigmentosa-like skin lesions.


L-histidine derivative

A proteinogenic amino acid derivative resulting from the formal reaction of L-histidine at the amino group, carboxy group, or the imidazolyl moiety, or from the replacement of any hydrogen of L-histidine by a heteroatom.


regulation of salicylic acid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid.


regulation of salicylic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid.


progressive myoclonic epilepsy type 9

Any progressive myoclonic epilepsy in which the cause of the disease is a mutation in the LMNB2 gene.


Inflammatory Malignant Fibrous Histiocytoma NCI Grade 2


dipsogenic diabetes insipidus

Diabetes insipidus caused by excessive intake of water due to psychological factors or damage to the thirst-regulating mechanism.


estrogen binding

Binding to an estrogen.


pyrimidine deoxyribonucleoside monophosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar.


purine ribonucleotide salvage

Any process which produces a purine ribonucleotide from derivatives of it, without de novo synthesis.


CMP catabolic process

The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate.


UMP catabolic process

The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate.


CMP metabolic process

The chemical reactions and pathways involving CMP, cytidine monophosphate.


glycolytic process from mannose through fructose-6-phosphate

The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.


GDP-L-fucose salvage

The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30).


diadenosine triphosphate metabolic process

The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached.


pyrimidine ribonucleoside monophosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar.


NAD catabolic process

The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH.


bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process

The chemical reactions and pathways resulting in the formation of bis(molybdopterin guanine dinucleotide)molybdenum.


nicotinate nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid).


guanine deglycation, glyoxal removal

The removal of glyoxal from a glycated guanine, to form glycolate and a deglycated guanine.


pyrimidine ribonucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.


diadenosine pentaphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate.


glycolytic process from sucrose through glucose and fructose

The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.


very long-chain fatty-acyl-CoA metabolic process

The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


bis(5'-nucleosidyl) oligophosphate metabolic process

The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules.


diadenosine triphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached.


purine ribonucleotide interconversion

The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide.


NAD biosynthesis via nicotinamide riboside salvage pathway

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside.


The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide.


pyrimidine ribonucleoside diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.


ribonucleoside triphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.


flavin adenine dinucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.


bis(molybdopterin guanine dinucleotide)molybdenum metabolic process

The chemical reactions and pathways involving bis(molybdopterin guanine dinucleotide)molybdenum.


CMP phosphorylation

The process of introducing a phosphate group into CMP, cytidine monophosphate, to produce CDP. Addition of two phosphate groups produces CTP.


pyrimidine nucleoside monophosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.


diadenosine hexaphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of diadenosine hexaphosphate.


bis(5'-nucleosidyl) oligophosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules.


very long-chain fatty-acyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


glycolytic process from sucrose

The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.


AMP phosphorylation

The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP.


glycolytic process via Entner-Doudoroff Pathway

A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes.


pyrimidine nucleotide interconversion

The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide.


diadenosine pentaphosphate metabolic process

The chemical reactions and pathways involving diadenosine pentaphosphate.


glycolytic process from galactose

The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP.


pyrimidine nucleoside triphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.


purine nucleotide interconversion

The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide.


nicotinate nucleotide metabolic process

The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin).


diadenosine triphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached.


purine ribonucleoside bisphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar.


glycolytic process through glucose-1-phosphate

The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.


purine deoxyribonucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.


flavin adenine dinucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.


purine deoxyribonucleoside monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.


CMP salvage

Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis.


nicotinate nucleotide salvage

The generation of nicotinate nucleotide without de novo synthesis.


diadenosine tetraphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached.


nicotinamide nucleotide biosynthetic process from niacinamide

The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide.


glycolytic process from fructose through fructose-6-phosphate

The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate.


medium-chain fatty-acyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


diadenosine hexaphosphate metabolic process

The chemical reactions and pathways involving diadenosine hexaphosphate.


The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide.


pyridine nucleotide salvage

Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis.


dAMP phosphorylation

The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP.


XMP salvage

Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis.


pyrimidine nucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.


glycolysis from storage polysaccharide through glucose-1-phosphate

The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH.


purine deoxyribonucleoside monophosphate metabolic process

The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.


pyrimidine ribonucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


GMP salvage

Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis.


guanine deglycation, methylglyoxal removal

The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine.


diadenosine polyphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached.


NAD salvage

Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam).


pyrimidine ribonucleoside triphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.


pyrimidine ribonucleoside diphosphate metabolic process

The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.


deoxyribonucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.


glycolytic process from glycerol

The glycolytic process in which glycerol is catabolized to pyruvate generating ATP and NADH.


nicotinate nucleotide biosynthetic process from tryptophan

The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan.


guanine deglycation

The removal of a sugar or dicarbonyl from a glycated guanine.


dCMP phosphorylation

The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP.


photosynthetic NADP+ reduction

An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions.


purine deoxyribonucleoside monophosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.


pyrimidine deoxyribonucleoside triphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.


CMP biosynthetic process

The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate.


transport-coupled glycolytic process through glucose-6-phosphate

The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport.


The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide.


glycolytic process through fructose-1-phosphate

The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH.


pyrimidine deoxyribonucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.


purine ribonucleoside triphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.


bis(5'-nucleosidyl) oligophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules.


histone serotonyltransferase activity

Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+).


peptide serotonyltransferase activity

Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+).


GDP biosynthetic process

The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate.


GDP catabolic process

The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate.


Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O.


negative regulation of locomotion involved in locomotory behavior

Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.


adult papillary meningioma

A papillary meningioma occurring in adults.


cyclitol

A polyol consisting of a cycloalkane containing at least three hydroxy groups, each attached to a different ring carbon atom.


B Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21

B-acute lymphoblastic leukemia characterized by amplification of a portion of chromosome 21. It usually occurs in children and is associated with an adverse prognosis.


distal interphalangeal joint of digit 5

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A distal interphalangeal joint that is part of a digit 5.


synovial joint

Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA].


humeroulnar joint

The humeroulnar joint, is part of the elbow-joint or the Olecron Joint, between the ulna and humerus bones is the simple hinge-joint, which allows for movements of flexion, extension and circumduction. The Humero-Ulnar Joint is the junction of trochlear notch of the ulna and the trochlea of the humerus. Owing to the obliquity of the trochlea of the humerus, this movement does not take place in the antero-posterior plane of the body of the humerus. When the forearm is extended and supinated, the axis of the arm and forearm are not in the same line; the arm forms an obtuse angle with the forearm. During flexion, however, the forearm and the hand tend to approach the middle line of the body, and thus enable the hand to be easily carried to the face. The accurate adaptation of the trochlea of the humerus, with its prominences and depressions, to the semilunar notch of the ulna, prevents any lateral movement. Flexion is produced by the action of the Biceps brachii and Brachialis, assisted by the Brachioradialis, with a tiny contribution from the muscles arising from the medial epicondyle of the humerus. Extension is produced by the Triceps brachii and AnconC&us, with a tiny contribution from the muscles arising from the lateral epicondyle of the humerus, such as the Extensor digitorum communis.


interphalangeal joint of pedal digit 1

An interphalangeal joint of pes that is part of a pedal digit 1.


distal interphalangeal joint of digit 3

A distal inter-phalangeal joint that is part of the 3rd digit.


metacarpophalangeal joint of manual digit 2

A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 2.


distal interphalangeal joint of pedal digit 4


intraramal joint

A joint in the lower jaw that enhances kinesis and for swallowing prey. Allows enhanced mobility and intraramal bending to increase gape.


femorotibial joint

One of the two primary bendings of a typical leg, pertains to the femur and the tibia.


metacarpophalangeal joint

The metacarpophalangeal joints (MCP) are of the condyloid kind, formed by the reception of the rounded heads of the metacarpal bones into shallow cavities on the proximal ends of the first phalanges, with the exception of that of the thumb, which presents more of the characters of a ginglymoid joint. Arthritis of the MCP is a distinguishing feature of Rheumatoid Arthritis, as opposed to the distal interphalangeal joint in osteoarthritis. [WP,unvetted].


intermetacarpal joint

A skeletal joint that connects two adjacent metacarpals[FMA,modified].


distal interphalangeal joint of pedal digit 3

A distal inter-phalangeal joint that is part of the 3rd pedal digit.


tarsometatarsal joint

The tarsometatarsal articulations are arthrodial joints in the pes.


distal interphalangeal joint of manural digit 5


metatarsophalangeal joint

The metatarsophalangeal articulations are the joints between the metatarsal bones of the foot and the proximal bones of the toes . They are condyloid joints meaning an elliptical or rounded surface (of the metatarsal bones) come close to the shallow cavities (of the proximal phalanges). The ligaments are the plantar and two collateral.


costotransverse joint

The facet of the tubercle of the rib forms an articulation with the adjacent transverse process of a thoracic vertebra. This is a plane type synovial joint called the costotransverse joint. This articulation is present in all but the eleventh and twelfth ribs. Ribs 1 to 10 have two joints in close proximity posteriorly; the costovertebral joints and the costotranseverse joints. This arrangement restrains the motion of the ribs allowing them to work in a parallel fashion during breathing. If a typical rib had only one joint posteriorly the resultant swivel action would allow a rib to be non-parallel with respect to the neighboring ribs making for a very inefficient respiratory mechanism. The ventral rami innervate the costotransverse joints. Therefore, therapeutic medial branch blocks are ineffectual. The ligaments of the joint are: Articular capsule Posterior costotransverse Anterior costotransverse Ligament of the neck of the rib Ligament of the tubercle of the rib.


pes joint

A skeletal joint that is part of a pes [Automatically generated definition].


crurotarsal joint

A joint that connects the bones of the crus to the proximal tarsal bones.


distal interphalangeal joint

An inter-phalangeal joint that connects a distal phalanx to either a medial or proximal phalanx.


metatarsophalangeal joint of pedal digit 5

A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 5.


interphalangeal joint of pes

The interphalangeal articulations of the foot (articulations of the phalanges) are ginglymoid joints, and each has a plantar and two collateral ligaments. The arrangement of these ligaments is similar to that in the metatarsophalangeal articulations: the Extensor tendons supply the places of dorsal ligaments.


synovial joint of pelvic girdle

A synovial joint that is part of a pelvic girdle region.


interphalangeal joint of pedal digit 4

An interphalangeal joint of pes that is part of a pedal digit 4.


proximal interphalangeal joint of little finger


carpometacarpal joint

The carpometacarpal joints (CMC) are joints in the wrist that articulates the distal row of carpal bones and the proximal bases of the metacarpal bones.


metacarpophalangeal joint of manual digit 1

A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 1.


synovial joint of pectoral girdle

A synovial joint that is part of a pectoral girdle region.


distal interphalangeal joint of digit 2

A distal interphalangeal joint that is part of a digit 2.


interphalangeal joint of manual digit 3

An interphalangeal joint of manus that is part of a manual digit 3.


distal interphalangeal joint of pedal digit 2


radio-carpal joint

A skeletal joint that connects a radius bone and connects a carpal skeleton.


costovertebral joint

The costovertebral joints are the articulations that connect the heads of the ribs with the bodies of the thoracic vertebrae. Joining of ribs to the vertebrae occurs at two places, the head and the tubercle of the rib. Two convex facets from the head attach to two adjacent vertebrae. This forms a trochoid joint, which is strengthened by the ligament of the head and the intercapital ligament. Articulation of the tubercle is to the transverse process of the adjacent vertebrae. This articulation is reinforced by the dorsal costotransverse ligament. [WP,unvetted].


cricothyroid joint

The cricoarytenoid articulation (or joint) is a joint connecting the cricoid cartilage and the thyroid cartilage.


distal interphalangeal joint of pedal digit 5


synovial limb joint

Any synovial joint that is part of a (free) limb.


intercarpal joint

A skeletal joint that connects two carpal bones.


distal interphalangeal joint of manual digit 3

A distal inter-phalangeal joint that is part of the 3rd manual digit.


interphalangeal joint of pedal digit 3

An interphalangeal joint of pes that is part of a pedal digit 3.


distal radio-ulnar joint

The Distal Radioulnar Articulation (inferior radioulnar joint) is a pivot-joint formed between the head of the ulna and the ulnar notch on the distal radius.


pisiform joint

It is a joint between the pisiform and triquetrum.


interphalangeal joint

A joint that connects one phalanx to another along a proximodistal axis.


intermetatarsal joint

A joint that connects two adjacent metatarsals.


wrist joint

A joint connecting the forelimb zeugopod skeleton with the carpal skeleton.


incudostapedial joint

The small synovial joint connecting the inclus and the stapes, located between the lenticular process on the long crus of the incus and the head of the stapes.


interphalangeal joint of manual digit 1

An interphalangeal joint of manus that is part of a manual digit 1.


metatarsophalangeal joint of pedal digit 1

A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 1.


subtalar joint

A joint of the pes that connects the talus and the calcaneus.


quadrate-articular joint

A skeletal joint that connects quadrate and articular bones.


cervical vertebral arch joint

A vertebral arch joint that is part of a cervical region of vertebral column.


interphalangeal joint of manus

The interphalangeal articulations of hand are hinge-joints of the phalanges of the hand. There are two sets (except in the thumb): 'proximal interphalangeal joints' (PIP), those between the first (also called proximal) and second (intermediate) phalanges 'distal interphalangeal joints' (DIP), those between the second and third (distal) phalanges A similar group of articulations also function in the toes.


proximal interphalangeal joint

An inter-phalangeal joint that connects a proximal phalanx to either a medial or distal phalanx.


sternocostal joint

Arthrodial joints, with the exception of the first, in which the cartilage is directly united with the sternum, and which is, therefore, a synarthrodial articulation.


condylar joint

In a condyloid joint (condyloid articulation, ellipsoidal joint) an ovoid articular surface, or condyle, is received into an elliptical cavity. This permits movement in two planes, allowing flexion, extension, adduction, abduction, and circumduction.


intertarsal-type crurotarsal joint

An ankle joint that passes between the astragalus and calcaneum.


metatarsophalangeal joint of pedal digit 4

A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 4.


metacarpal/tarsal-phalangeal joint

A skeletal joint that connects a mesopodium bone and connects a proximal phalanx.


joint of auditory ossicle

Any synovial joint that connects auditory ossicles.


metatarsophalangeal joint of pedal digit 2

A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 2.


laryngeal joint

A skeletal joint that connects a laryngeal cartilage.


mesotarsal joint

An ankle joint that passes between the proximal and distal tarsals.


interphalangeal joint of pedal digit 5

An interphalangeal joint of pes that is part of a pedal digit 5.


stifle joint

A complex joint in the hind limbs of quadruped mammals such as the sheep, horse or dog. It is the equivalent joint to the human knee. It is often the largest synovial joint in the body.


joint connecting upper and lower jaws

Synovial joint that articulates bones of upper and lower jaw.


transverse tarsal joint

The transverse tarsal joint is formed by the articulation of the calcaneus with the cuboid, and the articulation of the talus with the navicular. The movement which takes place in this joint is more extensive than that in the other tarsal joints, and consists of a sort of rotation by means of which the foot may be slightly flexed or extended, the sole being at the same time carried medially (inverted) or laterally.


interphalangeal joint of manual digit 5

An interphalangeal joint of manus that is part of a manual digit 5.


radio-ulnar joint

A joint that connects the radius and the ulna. Examples: proximal and distal radio-ulnar joints.


interphalangeal joint of pedal digit 2

An interphalangeal joint of pes that is part of a pedal digit 2.


exoccipital-atlas joint

A synovial joint that connects a vertebral bone 1 and connects a exoccipital bone.


midcarpal joint

An intercarpal that connects a proximal and distal carpal bone.


metacarpophalangeal joint of manual digit 3

A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 3.


incudomallear joint

The saddle-shaped synovial joint connecting the incus and the malleus.


metacarpophalangeal joint of manual digit 5

A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 5.


atlanto-occipital joint

The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital.


metatarsophalangeal joint of pedal digit 3

A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 3.


manus joint

A skeletal joint that is part of a manus (hand) [Automatically generated definition].


acromioclavicular joint

Any joint connecting the acromonion of the scapula and clavicle.


cricoarytenoid joint

The cricoarytenoid articulation (or joint) is a joint connecting the cricoid cartilage and the arytenoid cartilage.


distal interphalangeal joint of digit 4

A distal interphalangeal joint that is part of a digit 4.


proximal radio-ulnar joint

The proximal radioulnar articulation (superior radioulnar joint) is a trochoid or pivot joint between the circumference of the head of the radius and the ring formed by the radial notch of the ulna and the annular ligament.


tibiotalar joint

A skeletal joint that connects a tibia and connects a talus.


distal interphalangeal joint of manual digit 2


calcaneocuboid joint

Calcaneocuboid Articulation (articulation of the calcaneus with the cuboid). The ligaments connecting the calcaneus with the cuboid are five in number, viz. , the articular capsule, the dorsal calcaneocuboid, part of the bifurcated, the long plantar, and the plantar calcaneocuboid.


talocalcaneonavicular joint

The talocalcaneonavicular articulation is an arthrodial joint: the rounded head of the talus being received into the concavity formed by the posterior surface of the navicular, the anterior articular surface of the calcaneus, and the upper surface of the plantar calcaneonavicular ligament. There are two ligaments in this joint: the articular capsule and the dorsal talonavicular.


temporomandibular joint

A synovial joint of the jaw that connects the mandible to the temporal bone.


interphalangeal joint of manual digit 2

An interphalangeal joint of manus that is part of a manual digit 2.


carpometacarpal joint of digit 1

A carpometacarpal joint that connects to metacarpal 1.


metacarpophalangeal joint of manual digit 4

A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 4.


intertarsal joint

Intertarsal articulations are the joints of the tarsus. The specific intertarsal articulations are: Talocalcaneal articulation Talocalcaneonavicular articulation Calcaneocuboid articulation Cuneonavicular articulation Cuboideonavicular articulation Intercuneiform articulation Cuneocuboid articulation.


fusion of virus membrane with host macropinosome membrane

Fusion of a viral membrane with a host macropinosome membrane, that occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents into the host cell cytoplasm.


Matthew-Wood syndrome

Matthew-Wood syndrome is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia.


negative regulation of acetylcholine secretion, neurotransmission

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine.


inferior rectal artery

The inferior rectal artery (inferior hemorrhoidal artery) is an artery that supplies blood to the lower half of the anal canal. [WP,unvetted].


Testicular Mixed Germ Cell-Sex Cord-Stromal Tumor

A testicular mixed germ cell-sex cord-stromal tumor in which the neoplastic germ cells and the neoplastic sex cord-stromal cells do not form nests and are instead arranged in a diffuse pattern.


N-acyl-D-amino-acid deacylase activity

Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid.


Empyema with fistula

An empyema with a fistula.


insect adult head

Head of the adult organism.


structural constituent of carboxysome shell

The action of a molecule that contributes to the structural integrity of a carboxysome shell, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO2.


rhombomere 3 formation

The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


CD27 receptor binding

Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells.


positive regulation of CD4 production

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.


regulation of CD4 production

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.


negative regulation of CD4 production

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.


intracellular auxin homeostasis

A homeostatic process involved in the maintenance of a steady state level of auxin within a cell.


carbon catabolite repression of transcription from RNA polymerase II promoter by glucose

A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.


negative regulation of transcription by glucose

Any process involving glucose that decreases the frequency, rate or extent or transcription.


negative regulation of transcription from RNA polymerase II promoter by glucose

Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter.


congenital plasminogen activator inhibitor type 1 deficiency

Congenital plasminogen activator inhibitor type 1 (PAI-1) deficiency is a rare genetic bleeding disorder characterized by premature lysis of hemostatic clots and a moderate bleeding tendency.


Advanced Progesterone Receptor-Positive Breast Carcinoma

Progesterone receptor-positive breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Adenocarcinoma

An adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Ovarian Clear Cell Adenocarcinoma

Ovarian clear cell adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Breast Adenocarcinoma

Breast adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Intrahepatic cholangiocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Sebaceous Carcinoma

Sebaceous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Distal Bile Duct Adenocarcinoma

Distal bile duct adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced renal cell carcinoma

Renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Prostate Adenocarcinoma with Neuroendocrine Differentiation

Prostate adenocarcinoma with neuroendocrine differentiation that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Gastric Adenocarcinoma

Gastric adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Hormone Receptor-Negative Breast Carcinoma

Hormone receptor-negative breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Unresectable Gastric Adenocarcinoma

A gastric adenocarcinoma that has spread from its original site of growth to distant anatomic sites and is not amenable to surgical resection.


Advanced Chromophobe Renal Cell Carcinoma

Chromophobe renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Unclassified Renal Cell Carcinoma

Unclassified renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Triple-Negative Breast Carcinoma

Triple-negative breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Cervical Adenocarcinoma

A cervical adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Hepatocellular Carcinoma

Hepatocellular carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Cholangiocarcinoma

A cholangiocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Estrogen Receptor-Positive Breast Carcinoma

Estrogen receptor-positive breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Endometrial Adenocarcinoma

Endometrial adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Appendix Adenocarcinoma

Appendix adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Sarcomatoid Renal Cell Carcinoma

Sarcomatoid renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Hilar Cholangiocarcinoma

Hilar cholangiocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Clear Cell Renal Cell Carcinoma

A clear cell renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Adult Hepatocellular Carcinoma

A hepatocellular carcinoma that occurs during adulthood and has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Papillary Renal Cell Carcinoma

A papillary renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Endometrial Serous Adenocarcinoma

Endometrial serous adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Vaginal Adenocarcinoma

Vaginal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Colorectal Adenocarcinoma

Colorectal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Esophageal Adenocarcinoma

Esophageal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced HER2-Positive Breast Carcinoma

HER2-positive breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Adenocarcinoma of Unknown Primary

An adenocarcinoma of unknown primary that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Hormone Receptor-Positive Breast Carcinoma

Hormone receptor-positive breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Rectal Adenocarcinoma

Rectal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Lung Adenocarcinoma

Lung adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Colon Adenocarcinoma

Colon adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Fibrolamellar Carcinoma

Fibrolamellar carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Endometrioid Adenocarcinoma

Endometrioid adenocarcinoma that has spread extensively from the original site of growth to other anatomic sites or is no longer responding to treatment.


Advanced HER2-Negative Breast Carcinoma

HER2-negative breast adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Prostate Adenocarcinoma

A prostatic adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Ovarian Endometrioid Adenocarcinoma

Ovarian endometrioid adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.