positive regulation of hepatic stellate cell migration

Any process that increases the frequency, rate or extent of hepatic stellate cell migration.


4p16.3 microduplication syndrome

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

4p16.3 microduplication syndrome is a rare genetic syndrome that results from the partial duplication of the short arm of chromosome 4. It has a highly variable phenotype, principally characterized by psychomotor and language delay, seizures and dysmorphic features such as high forehead with frontal bossing, hypertelorism, prominent glabella, long narrow palpebral fissures, low set ears and short neck. Eye abnormalities (glaucoma, irregular iris pigmentation, hyperopia) have also been reported.


positive regulation of neutrophil activation

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that activates or increases the frequency, rate or extent of neutrophil activation.


developmental and epileptic encephalopathy, 62


Intraocular Infection

Infection within the eye.


Fungal endophthalmitis

Inflammation of the lining of the ocular cavities, which results from a fungal infection.


parasitic endophthalmitis

Infection of the epicondyles by a parasite.


cellular response to L-glutamate

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus.


establishment of latency as a circular episome

A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a circular structure.


establishment of episomal latency

A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a distinct genetic entity.


establishment of latency as a linear episome

A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as linear structure.


caudate lobe hepatic sinusoid

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A hepatic sinusoid that is part of a caudate lobe of liver.


peroxisome membrane class-1 targeting sequence binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner.


autoimmune vasculitis

An autoimmune form of vasculitis.


rheumatoid vasculitis

Necrotizing VASCULITIS of small and medium size vessels, developing as a complication in RHEUMATOID ARTHRITIS patients. It is characterized by peripheral vascular lesions, cutaneous ulcers, peripheral gangrene, and mononeuritis multiplex.


positive regulation of estrogen secretion

Any process that activates or increases the frequency, rate or extent of estrogen secretion.


Toc complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Protein translocon complex at the chloroplast outer membrane.


Benign Epithelial Melanoses of the Conjunctiva

A group of benign, non-neoplastic lesions in the conjunctiva characterized by increased production of melanin without proliferation of conjunctival melanocytes.


Branch of abdominal aorta

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An arterial segment arising from the abdominal aorta that supplies blood to the abdominal organs, other structures, genitalia and the lower limbs. The aortic branches include terminal branches called the common iliac arteries, the celiac artery, the superior mesenteric artery, the inferior mesenteric artery, the renal arteries, the suprarenal arteries, the testicular (internal spermatic) arteries, the ovarian arteries, the inferior phrenic arteries, lumbar arteries and the middle sacral artery.


left common iliac artery

The common iliac artery situated on the left side of the body.


common iliac artery

The common iliac arteries are two large arteries, about 4cm long in adults but more than a centimetre in diameter, that originate from the aortic bifurcation. The arteries run inferolaterally, along the medial border of the psoas muscles to the pelvic brim, where they bifurcate into the external iliac artery and internal iliac artery. The common iliac artery, and all of its branches, exist as paired structures (that is to say, there is one on the left side and one on the right). The distribution of the common iliac artery is basically the pelvis and lower limb on the corresponding side. Both common iliac arteries are accompanied along their course by common iliac veins. [WP,unvetted].


iliolumbar artery

The iliolumbar artery is a branch of the posterior trunk of the internal iliac artery. [WP,unvetted].


left testicular artery

A testicular artery that supplies a left testicle.


spermatic artery

A branch of the abdominal aorta that supplies oxygenated blood to the testis.


phrenic artery

An artery that supplies the diaphragm.


left gastric artery

An artery that arises from the celiac artery and supplies the stomach.


right testicular artery

A testicular artery that supplies a right testicle.


mesenteric artery

Arteries which arise from the abdominal aorta and distribute to most of the intestines.


suprarenal artery

Artery that supplies blood to the adrenal glands.


ovarian artery

An artery that supplies an ovary.


right renal artery

Renal artery that supplies the right kidney.


lumbar artery

The lumbar arteries are in series with the intercostals. They are usually four in number on either side, and arise from the back of the aorta, opposite the bodies of the upper four lumbar vertebrC&. A fifth pair, small in size, is occasionally present: they arise from the middle sacral artery. They run lateralward and backward on the bodies of the lumbar vertebrC&, behind the sympathetic trunk, to the intervals between the adjacent transverse processes, and are then continued into the abdominal wall. The arteries of the right side pass behind the inferior vena cava, and the upper two on each side run behind the corresponding crus of the diaphragm. The arteries of both sides pass beneath the tendinous arches which give origin to the Psoas major, and are then continued behind this muscle and the lumbar plexus. They now cross the Quadratus lumborum, the upper three arteries running behind, the last usually in front of the muscle. At the lateral border of the Quadratus lumborum they pierce the posterior aponeurosis of the Transversus abdominis and are carried forward between this muscle and the Obliquus internus. They anastomose with the lower intercostal, the subcostal, the iliolumbar, the deep iliac circumflex, and the inferior epigastric arteries.


left renal artery

Renal artery that supplies the left kidney.


inferior suprarenal artery

Each renal artery gives off some small inferior suprarenal branches to the suprarenal gland, the ureter, and the surrounding cellular tissue and muscles. [WP,unvetted].


Accessory Renal Artery

An additional renal artery originating from the aorta. Accessory renal arteries are found in 26-30% of humans.


superior suprarenal artery

Each (left and right) superior suprarenal artery is a branch of the inferior phrenic artery on that side of the body. The left and right phrenic arteries supply the diaphragm, and come off the aorta. [WP,unvetted].


right common iliac artery

The common iliac artery situated on the right side of the body.


iliac artery

Any of the arteries that arise from a bifurcation of the aorta supplying the pelvic or abdomen. Examples: Common iliac artery, External iliac artery, Internal iliac artery.


Recurrent Breast Acinic Cell Carcinoma

The reemergence of acinic cell breast carcinoma after a period of remission.


immunoskeletal dysplasia with neurodevelopmental abnormalities


cranial nodular fasciitis

A rare self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the cranium. This is an osteolytic lesion. It is characterized by the presence of plump spindle-shaped fibroblasts, multinucleated osteoclast-like giant cells, chronic inflammatory infiltrate, red blood cell extravasation, and high mitotic activity.


positive regulation of syringal lignin catabolic process

Any process that activates or increases the frequency, rate or extent of syringal lignin catabolic process.


Stage V Kidney Wilms Tumor

Wilms tumor that affects both kidneys at the same time. The tumor in each kidney is staged separately (National Wilms Tumor Study Group Staging System)


Kv4.3-KChIP1 channel complex

A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3.


type IV site-specific deoxyribonuclease activity

Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated).


negative regulation of nucleobase-containing compound metabolic process

Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.


negative regulation of single-strand break repair via homologous recombination

Any process that stops, prevents or reduces the frequency, rate or extent of single-strand break repair via homologous recombination.


negative regulation of pyruvate kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate kinase activity.


negative regulation of poly(A)-specific ribonuclease activity

Any process that stops, prevents or reduces the frequency, rate or extent of poly(A)-specific ribonuclease activity.


negative regulation of double-strand break repair via single-strand annealing

Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via single-strand annealing.


negative regulation of exoribonuclease activity

Any process that stops, prevents or reduces the frequency, rate or extent of exoribonuclease activity.


negative regulation of exonucleolytic catabolism of deadenylated mRNA

Any process that stops, prevents, or reduces the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay.


negative regulation of transcription elongation by RNA polymerase I

Any process that stops, prevents or reduces the frequency, rate or extent of transcription elongation mediated by RNA polymerase I.


negative regulation of termination of RNA polymerase I transcription

Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase I transcription.


symbiont-mediated suppression of host mRNA splicing

A process in which a symbiont inhibits or disrupts the splicing of host mRNA, thus interfering with normal host protein production. The host is defined as the larger of the organisms involved in a symbiotic interaction.


negative regulation of reciprocal meiotic recombination

Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.


negative regulation of transcription by transcription factor catabolism

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


negative regulation of termination of DNA-templated transcription

Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.


negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels

Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.


negative regulation of DNA ligation

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.


negative regulation of protection from non-homologous end joining at telomere

Any process that stops, prevents or reduces the frequency, rate or extent of protection from non-homologous end joining at telomere.


replication fork arrest at mating type locus

A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus.


negative regulation of endoribonuclease activity

Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.


negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination

Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination.


negative regulation of apoptotic DNA fragmentation

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation.


negative regulation of reverse transcription

Any process that stops, prevents or reduces the frequency, rate or extent of reverse transcription.


negative regulation of error-prone translesion synthesis

Any process that stops, prevents or reduces the frequency, rate or extent of error-prone translesion synthesis.


negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress

Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a disturbance in organismal or cellular homeostasis.


negative regulation of mitotic recombination-dependent replication fork processing

Any process that inhibits or decreases the rate of mitotic recombination-dependent replication fork processing. Suppression of recombination at replication forks is necessary to prevent template switching.


negative regulation of mitotic DNA replication initiation from late origin

Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication.


negative regulation of telomere single strand break repair

Any process that stops, prevents or reduces the frequency, rate or extent of telomere single strand break repair.


negative regulation of DNA ligase activity

Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligase activity.


negative regulation of pyrimidine nucleotide biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of pyrimidine nucleotide biosynthetic process.


carbon catabolite repression of transcription by galactose

A transcription regulation process in which the presence of galactose that leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.


negative regulation of mRNA cis splicing, via spliceosome

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cis splicing, via spliceosome.


negative regulation of meiotic DNA double-strand break formation

Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation.


telomerase RNA stabilization

Prevention of degradation of telomerase RNA (TERC) molecules.


negative regulation of DNA strand resection involved in replication fork processing

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing.


negative regulation of single strand break repair

Any process that stops, prevents or reduces the frequency, rate or extent of single strand break repair.


negative regulation of miRNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of miRNA metabolic process.


negative regulation of DNA primase activity

Any process that stops, prevents or reduces the frequency, rate or extent of DNA primase activity.


negative regulation of telomerase RNA reverse transcriptase activity

Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA reverse transcriptase activity.


negative regulation of type III site-specific deoxyribonuclease activity

Any process that stops or reduces the rate of type III restriction endodeoxyribonuclease activity.


negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA

Any process that stops, prevents, or reduces the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA.


negative regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts

Any process that stops, prevents or reduces the frequency, rate or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein.


negative regulation of DNA amplification

Any process that stops, prevents or reduces the frequency, rate or extent of DNA amplification.


negative regulation of telomeric loop disassembly

Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop disassembly.


replication fork arrest at tRNA locus

A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit.


negative regulation of snRNA transcription by RNA polymerase II

Any process that stops, prevents or reduces the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II.


negative regulation of mitotic cell cycle DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication.


negative regulation of RNA metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.


negative regulation of exodeoxyribonuclease activity

Any process that stops, prevents or reduces the frequency, rate or extent of exodeoxyribonuclease activity.


negative regulation of telomere maintenance in response to DNA damage

Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance in response to DNA damage.


negative regulation of nuclear-transcribed mRNA poly(A) tail shortening

Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.


inactivation of recombination (HML)

The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae.


negative regulation of mRNA modification

Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


negative regulation of type I site-specific deoxyribonuclease activity

Any process that stops or reduces the rate of type I restriction endodeoxyribonuclease activity.


negative regulation of mating-type specific transcription, DNA-templated

Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-templated transcription.


negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.


nitrogen catabolite repression of transcription from RNA polymerase II promoter

A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.


negative regulation of type II site-specific deoxyribonuclease activity

Any process that stops or reduces the rate of type II restriction endodeoxyribonuclease activity.


negative regulation of siRNA processing

Any process that stops, prevents or reduces the frequency, rate or extent of siRNA processing.


negative regulation of endodeoxyribonuclease activity

Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.


negative regulation of DNA-templated DNA replication initiation

Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.


negative regulation of type IV site-specific deoxyribonuclease activity

Any process that stops or reduces the rate of type IV restriction endodeoxyribonuclease activity.


negative regulation of DNA recombination at centromere

Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination at the centromere.


negative regulation of mismatch repair

Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair.


replication fork arrest

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected.


negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source

A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.


negative regulation of telomere maintenance via recombination

Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.


negative regulation of telomeric D-loop disassembly

Any process that stops, prevents or reduces the frequency, rate or extent of telomeric D-loop disassembly.


negative regulation of ribosomal protein gene transcription by RNA polymerase II

Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II.


negative regulation of mitochondrial mRNA catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial mRNA catabolic process.


tRNA stabilization

Prevention of degradation of tRNA molecules.


negative regulation of deoxyribonuclease activity

Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.


negative regulation of glycolytic process through fructose-6-phosphate

Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate.


negative regulation of DNA replication initiation involved in plasmid copy number maintenance

Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance.


negative regulation of mitotic DNA replication initiation

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication.


negative regulation of restriction endodeoxyribonuclease activity

Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.


negative regulation of miRNA catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process.


negative regulation of exonuclease activity

Any process that stops, prevents or reduces the frequency, rate or extent of exonuclease activity.


carbon catabolite repression of transcription from RNA polymerase II promoter

A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.


negative regulation of initiation of premeiotic DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of initiation of premeiotic DNA replication.


negative regulation of DNA-directed DNA polymerase activity

Any process that stops, prevents or reduces the frequency, rate or extent of DNA-directed DNA polymerase activity.


negative regulation of tRNA catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of tRNA catabolic process.


replication fork arrest involved in DNA replication termination

A replication fork arrest process that contributes to the termination of DNA replication.


replication fork arrest at rDNA repeats

A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer.


negative regulation of strand invasion

Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.


negative regulation of DNA-templated transcription

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.


negative regulation of termination of RNA polymerase II transcription

Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription.


nitrogen catabolite repression of transcription

A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


negative regulation of ribonuclease activity

Any process that decreases the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.


negative regulation of double-strand break repair via break-induced replication

Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via break-induced replication.


negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled

Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled.


negative regulation of base-excision repair

Any process that stops, prevents or reduces the frequency, rate or extent of base-excision repair.


negative regulation of DNA methylation

Any process that stops, prevents or reduces the frequency, rate or extent of DNA methylation.


negative regulation of RNA polymerase III activity

Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase III activity.


negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus

Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a chemical stimulus.


carbon catabolite repression of transcription from RNA polymerase II promoter by galactose

Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.


transcription antitermination

A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions.


negative regulation of RNA biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.


detection of salicylic acid stimulus

The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal.


cellular response to salicylic acid stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus.


osmosensory signaling pathway via Sho1 osmosensor

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system.


osmosensory signaling pathway

The series of molecular signals initiated in response to osmotic change.


osmosensory signaling via phosphorelay pathway

The series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system. In S.cerevisiae, the osmosensor is the histidine kinase Sln1.


upper aerodigestive tract neoplasm

Soft tissue tumors or cancer arising from the mucosal surfaces of the lip; oral cavity; pharynx; larynx; and cervical esophagus. Other sites included are the nose and paranasal sinuses; salivary glands; thyroid gland and parathyroid glands; and melanoma and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)


Adenocarcinoma in multiple adenomatous polyps

Adenocarcinomas developing in gastrointestinal tract adenomas in patients with multiple adenomatous polyps.


Adenocarcinoma in adenomatous polyposis coli

Adenocarcinomas developing in colorectal adenomas in patients with a history of adenomatous polyposis coli. The mean age of development of adenocarcinoma is about 40 years.


alcoholic psychosis

A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.


childhood parosteal osteosarcoma

A low grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone. It occurs in childhood and usually affects the distal posterior femur, the proximal tibia, and proximal humerus. Painless swelling is the usual clinical sign. The prognosis is usually excellent.


peripheral osteosarcoma

A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the surface of the bone.


high grade surface osteosarcoma

A usually aggressive high grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone.


Childhood Periosteal Osteosarcoma

A periosteal osteosarcoma occurring in childhood.


periosteal osteogenic sarcoma

An intermediate grade malignant bone-forming mesenchymal neoplasm with chondroblastic differentiation. It arises from the surface of the bone and affects the diaphysis or diaphyseal- metaphyseal portion of the long bones. A painless mass or swelling is the most common clinical sign. It is associated with a better prognosis than conventional osteosarcoma.


juxtacortical osteosarcoma

A low grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone. It usually affects the distal posterior femur, the proximal tibia, and proximal humerus. Painless swelling is the usual clinical sign. Most patients are young adults and the prognosis is usually excellent.


medulla oblongata formation

The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.


calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity

Catalysis of the reactions: nucleoside 3',5'-cyclic AMP + H2O = AMP + H+; this activity is activated by binding to calcium-bound calmodulin.


chitobiose catabolic process

The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine.


N-acetylglucosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.


glycopeptide catabolic process

The chemical reactions and pathways resulting in the breakdown of glycopeptides, a compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide.


butirosin catabolic process

The chemical reactions and pathways resulting in the breakdown of butirosin.


anthocyanin-containing compound catabolic process

The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.


amino disaccharide catabolic process

The chemical reactions and pathways resulting in the breakdown of any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions.


gentamycin catabolic process

The chemical reactions and pathways resulting in the breakdown of gentamycin.


paromomycin catabolic process

The chemical reactions and pathways resulting in the breakdown of paromomycin.


The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate.


2-deoxyribose 1-phosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose.


O-sialoglycoprotein catabolic process

The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.


cuticle chitin catabolic process

The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles.


galactosylceramide catabolic process

The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.


The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.


amylopectin catabolic process

The chemical reactions and pathways resulting in the breakdown of an amylopectin.


glucuronoside catabolic process

The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue.


galactosaminoglycan catabolic process

The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose.


cell wall chitin catabolic process

The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells.


lincomycin catabolic process

The chemical reactions and pathways resulting in the breakdown of lincomycin.


neomycin catabolic process

The chemical reactions and pathways resulting in the breakdown of neomycin.


S-glycoside catabolic process

The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group.


D-tagatose 6-phosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a D-tagatose 6-phosphate.


ascospore wall chitin catabolic process

The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores.


lipoteichoic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.


lipopolysaccharide catabolic process

The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.


kanamycin catabolic process

The chemical reactions and pathways resulting in the breakdown of kanamycin.


diacetylchitobiose catabolic process

The chemical reactions and pathways resulting in the breakdown of diacetylchitobiose into simpler products.


diacetylchitobiose catabolic process to glucosamine and acetate

The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate.


aminoglycoside antibiotic catabolic process

The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin.


ergosteryl 3-beta-D-glucoside catabolic process

The chemical reactions and pathways resulting in the breakdown of ergosteryl 3-beta-D-glucoside.


N-acetylmannosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose.


mannosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins.


mannoprotein catabolic process

The chemical reactions and pathways resulting in the breakdown of a mannoprotein, a protein that contains covalently bound mannose residues.


teichoic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues.


heparin catabolic process

The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


lipooligosaccharide catabolic process

The chemical reactions and pathways resulting in the breakdown of lipooligosaccharide.


saponin catabolic process

The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection.


beta-glucoside catabolic process

The chemical reactions and pathways resulting in the breakdown of beta-glucoside.


zeaxanthin bis(beta-D-glucoside) catabolic process

The chemical reactions and pathways resulting in the breakdown of zeaxanthin bis(beta-D-glucoside).


elastin catabolic process

The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue.


fructosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.


U12-type post-mRNA release spliceosomal complex

A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs.


U12-type prespliceosome

A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.


U12-type precatalytic spliceosome

A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs.


U12-type post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U12 and U6atac.


U2-type post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6.


U12-type catalytic step 2 spliceosome

A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs.


U2-type precatalytic spliceosome

A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.


trans spliceosomal complex

A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates.


U12-type catalytic step 1 spliceosome

A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs.


U2-type catalytic step 2 spliceosome

A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.


A reactive cutaneous proliferation of macrophages. It is characterized by the presence of giant cells with ground-glass cytoplasm. It presents with multiple cutaneous or mucosal papules or nodules.


negative regulation of establishment of endothelial barrier

Any process that stops, prevents or reduces the frequency, rate or extent of establishment of endothelial barrier.


organ system subdivision

A subdivision of an anatomical system.


insect embryonic/larval central nervous system

Central nervous system of the embryo/larva.


insect adult central nervous system

Central nervous system of the adult.


subdivision of skeletal system

Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.


subdivision of skeleton

Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.


musculature

A subdivision of the muscular system corresponding to a subdisivision of an organism.


meckelian bone

The ossification of the Meckel's cartilage.


Epididymal Melanotic Neuroectodermal Tumor

A rare neoplasm that arises from the epididymis and is characterized by the presence of a mixture of melanin-containing epithelial cells and smaller neuroblast-like cells. It usually occurs in infants and has a benign clinical course.


ATP-dependent H2AZ histone chaperone activity

A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite.


maltose transporting porin activity

Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.


insulin-like growth factor binary complex

A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development.


regulation of telomeric loop disassembly

Any process that modulates the frequency, rate or extent of telomeric loop disassembly.


positive regulation of telomeric D-loop disassembly

Any process that activates or increases the frequency, rate or extent of telomeric D-loop disassembly.


positive regulation of telomeric loop disassembly

Any process that activates or increases the frequency, rate or extent of telomeric loop disassembly.


regulation of telomeric D-loop disassembly

Any process that modulates the frequency, rate or extent of telomeric D-loop disassembly.


left anterior cardinal vein

An anterior cardinal vein that is in_the_left_side_of a multicellular organism.


cardinal vein

Any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column.


left posterior cardinal vein

A posterior cardinal vein that is in_the_left_side_of a multicellular organism.


posterior cardinal vein

One of two paired cardinal veins that return blood from the body of the embryo[Kardong].


common cardinal vein

Either of a pair of large transverse venous sinuses that conduct blood from the cardinal veins to the sinus venosus of the vertebrate embryo[BTO].


right posterior cardinal vein

A posterior cardinal vein that is in_the_right_side_of a multicellular organism.


right anterior cardinal vein

An anterior cardinal vein that is in_the_right_side_of a multicellular organism.


anterior cardinal vein

One of the the two paired cardinal veins draining the cephalic part of the body.


facial nerve neoplasm

A neoplasm involving a facial nerve.


geniculate ganglionitis

Diseases of the facial nerve or nuclei. Pontine disorders may affect the facial nuclei or nerve fascicle. The nerve may be involved intracranially, along its course through the petrous portion of the temporal bone, or along its extracranial course. Clinical manifestations include facial muscle weakness, loss of taste from the anterior tongue, hyperacusis, and decreased lacrimation.


geniculate herpes zoster

A viral ear infection caused by the spread of varicella-zoster virus to the facial nerves. It is characterized by intense otalgia and a cutaneous vesicular eruption.


Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome

This syndrome is characterized by the association of MC6bius syndrome (congenital facial palsy with impaired ocular abduction) with peripheral axonal neuropathy and hypogonadotropic hypogonadism.


familial isolated deficiency of vitamin E

Ataxia with vitamin E deficiency (AVED) is a neurodegenerative disease belonging to the inherited cerebellar ataxias. It is mainly characterized by progressive spino-cerebellar ataxia, loss of proprioception, areflexia, and is associated with a marked deficiency in vitamin E.


hypertriglyceridemia 1

A laboratory test result indicating an autosomal dominant condition in which there is increased very low density lipoprotein production, which leads to increased triglyceride concentration.


positive regulation of pheromone response MAPK cascade

Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade.


positive regulation of ERK5 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.


positive regulation of cell wall integrity MAPK cascade

Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis.


tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity

Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA.


female somatic sex determination

The determination of sex and sexual phenotypes in a female organism's soma.


NIK deficiency

A immunodeficiency disorder caused by loss of function mutation in NIK (MAP3K14).


plasma membrane proton-transporting V-type ATPase, V0 domain

The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane.


lysosomal proton-transporting V-type ATPase, V0 domain

The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.


transient retinal arterial occlusion

A partial, temporary occlusion of the retinal artery.


arterial disorder

An impairment of the structure or function of the blood vessels which carry blood away from the heart.


Hepatic Arterial Occlusion

An occlusion of the hepatic artery.


Efferent Arteriolar Hyalinosis

The deposition of hyaline material in the wall of the efferent arterioles.


Vertebral Artery Dissection

A tear within the wall of a vertebral artery.


Dissection of renal artery

A tear within the wall of a renal artery.


Dissection, Thoracoabdominal Aorta

A tear within the wall of the thoracoabdominal aorta.


Dissection, Thoracic Aorta

A tear within the wall of the thoracic aorta.


Juvenile polyarteritis

Polyarteritis occurring in children or adolescents.


Systemic Arterial Hypertensive Disorder

Any condition resulting in systemically elevated blood pressure that is attributed to an arterial source.


coronary atherosclerosis

Atherosclerosis of the coronary vasculature.


Three Vessel Coronary Disease

There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in three coronary arteries (or greater than or equal to 50% stenosis in the left main coronary artery and greater than or equal to 50% stenosis in the right coronary artery). (ACC)


Dissection of iliac artery

A tear within the wall of an iliac artery.


generalized atherosclerosis

Atherosclerosis that is not localized.


arterial occlusion

Complete closure of the normally patent lumen of the blood vessels which carry blood away from the heart.


partial arterial retinal occlusion

A partial occlusion of the retinal artery.


Infectious Arteritis

A bacterial or viral infectious process affecting an artery.


Overlap Necrotizing Arteritis

A necrotizing arteritis that exhibits characteristic features of several distinct vascular disorders.


vasculitis due to ADA2 deficiency

Vasculitis due to ADA2 deficiency is a rare, genetic, systemic and rheumatologic disease due to adenosine deaminase-2 inactivating mutations, combining variable features of autoinflammation, vasculitis, and a mild immunodeficiency. Variable clinical presentation includes chronic or recurrent systemic inflammation with fever, livedo reticularis or racemosa, early-onset ischemic or hemorrhagic strokes, peripheral neuropathy, abdominal pain, hepatosplenomegaly, portal hypertension, cutaneous polyarteritis nodosa, variable cytopenia and immunoglobulin deficiency.


microscopic polyangiitis

Microscopic polyangiitis (MPA) is an inflammatory, necrotizing, systemic vasculitis that affects predominantly small vessels (i.e. small arteries, arterioles, capillaries, venules) in multiple organs.


Double coronary vessel disease

There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in two coronary arteries (or greater than or equal to 50% stenosis in the left main coronary artery). (ACC)


cerebral atherosclerosis

Atherosclerosis of the cerebral vasculature.


arteriolosclerosis

The thickening of the wall of the small arteries and arterioles. It is caused by deposition of hyaline material in the wall or concentric smooth muscle wall hypertrophy. It results in lumen narrowing and tissue ischemia.


Monckeberg arteriosclerosis

A type of arteriosclerosis in which calcification of the tunica media is the predominant feature.


One Vessel Coronary Disease

There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in one coronary artery. (ACC)


cutaneous polyarteritis nodosa

Cutaneous polyarteritis nodosa (CPAN) is a rare limited form of polyarteritis nodosa (PAN), characterized by cutaneous vasculitis and mild and transient extracutaneous manifestations such as mild arthralgia, arthritis,myalgia, and rarely peripheral neuropathy.


Generalised arteriosclerosis

Arteriosclerosis that is not localized.


Significant Arterial Dissection

A dissection that impairs flow. This includes Type C (a persisting contrast medium extravasation) in the presence of ischemia, Type D (a spiral filling defect with delayed but complete distal flow), Type E (persistent filling defect with delayed antegrade flow) and Type F (filling defect with impaired flow and total occlusion).


Hyaline arteriolosclerosis

The deposition of hyaline material in the wall of the arterioles.


granulomatous angiitis

Inflammation of the arteries that is characterized by the presence of granulomas.


Femoropopliteal Occlusive Disease

An occlusive disease of the femoropopliteal vascular system.


endarteritis

Inflammation of the arterial intima.


chorionic trophoblast cell proliferation

The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population.


Lung Radiation Injury

Radiation injury of the pulmonary system.


middle ear cholesterol granuloma

As accumulation of granulation tissue in the middle ear that results from the degeneration of blood and a chronic inflammatory response.


Cholesterol granuloma

A cystic inflammatory lesion that is comprised of fluids, lipids, and cholesterol crystals, and which is surrounded by a fibrous lining.


mycothiol biosynthetic process

The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione.


Bronchospasm, Exercise-Induced

Sudden contraction of the smooth muscles of the bronchial wall that occurs during or following exercise.


Drug-induced cutaneous lupus erythematosus

A reaction to a drug characterized by skin findings common to lupus including photosensitivity and butterfly rash; typically it resolves after drug discontinuation.


lupus erythematosus tumidus

Tumid erythematosus lupus is considered a rare type of chronic cutaneous lupus erythematosus. Cutaneous lupus erythematosus (CLE) can be divided into acute cutaneous lupus, subacute cutaneous lupus, and chronic cutaneous lupus. Tumid erythematosus lupus is characterized by smooth, non-scarring, pink- to violet-colored pimples (papules)on the skin without any other apparent skin changes, such as scarring. Patients with tumid lupus erythematosus usually do not have other symptoms of systemic lupus erythematosus or other types of cutaneous lupus erythematosus. The papules appear on sun-exposed areas of the face, upper back, V area of the neck, trunk, and arms, and more rarely on thighs and legs. They usually affect equally both sides of the body, but may affect only one side. Normally, the papules clear without leaving scars. The treatment is very effective in most cases, and may include sun protection, anti-malarials drugs, local corticosteroids, topical tacrolimus and light therapy.


subacute cutaneous lupus erythematosus

Subacute cutaneous lupus erythematosus (SCLE) is a form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. SCLE is associated with anti-Ro/SSA antibodies and can be drug-induced.


deoxyuridine biosynthetic process

The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA.


1,1,2-trichloroethene reductive dehalogenase activity

Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene.


Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+.


skin of manus

A zone of skin that is part of a manus [Automatically generated definition].


manual digit skin

A zone of skin that is part of a finger [Automatically generated definition].


skin of wrist

A zone of skin that is part of a wrist [Automatically generated definition].


cellular response to external biotic stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.


anatomical group

Anatomical structure consisting of at least two non-overlapping organs, multi-tissue aggregates or portion of tissues or cells of different types that does not constitute an organism, organ, multi-tissue aggregate, or portion of tissue.


clear cell sarcoma

A rare malignant neoplasm with melanocytic differentiation characterized by the presence of polygonal or spindle shaped clear cells. This sarcoma usually affects the tendons and aponeuroses and is associated with a poor prognosis due to recurrences and metastases.


Childhood Clear Cell Sarcoma of Soft Parts

A clear cell sarcoma of soft tissue occurring in children.


Metastatic Clear Cell Sarcoma of Soft Tissue

A clear cell sarcoma of soft tissue that has spread from the original site of growth to other anatomic sites.


Advanced Clear Cell Sarcoma of Soft Tissue

A clear cell sarcoma of soft tissue that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Clear Cell Sarcoma of Soft Tissue

The reemergence of clear cell sarcoma of soft tissue after a period of remission.


Refractory Clear Cell Sarcoma of Soft Tissue

Clear cell sarcoma of soft tissue that is resistant to treatment.


COG4-congenital disorder of glycosylation

COG4-CDG is an extremely rare form of CDG syndrome characterized clinically in the single reported case to date by seizures, some dysmorphic features, axial hyponia, slight peripheral hypertonia and hyperreflexia.


lateral motor column neuron differentiation

The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate.


primary cutaneous gamma/delta-positive T-cell lymphoma

Primary cutaneous gamma/delta-positive T-cell lymphoma is a rare, usually aggressive, subtype of cutaneous T-cell lymphoma characterized by infiltration of the epidermis, dermis or subcutaneous tissue by a clonal population of mature, gamma/delta positive cytotoxic T-cells. Typically it presents with ulcerating plaques, tumors, or subcutaneous nodules on the skin of the extremities, however, frequent involvement of mucosal and extranodal sites (such as the nasal cavity, gastrointestinal tract or lungs) is also observed. Cases associated with panniculitis may present with hemophagocytic syndrome (abrupt onset of fever, rash, cytopenia, hepatosplenomegaly and neurological compromise). Infiltration of lymph nodes, spleen and bone marrow is uncommon and resistance to multilineage chemotherapy is reported.


reactive gliosis

A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells.


prolonged electroretinal response suppression 2


prolonged electroretinal response suppression 1


Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine = 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine.


glycine dehydrogenase (decarboxylating) activity

Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.


oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group.


cardioblast migration to the midline involved in heart rudiment formation

The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment.


Locally Advanced Unresectable Gastric Adenocarcinoma

A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Metastatic Unresectable Carcinoma

A carcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


Metastatic Unresectable Basal Cell Carcinoma

A basal cell carcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


Locally Advanced Unresectable Esophageal Adenocarcinoma

Esophageal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Colorectal Adenocarcinoma

A colorectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Pancreatic Adenocarcinoma

A pancreatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Metastatic Unresectable Gastric Adenocarcinoma

A gastric adenocarcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


Locally Advanced Unresectable Triple-Negative Breast Carcinoma

Triple-negative breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Colon Adenocarcinoma

A colon adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Basal Cell Carcinoma

A basal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Carcinoma

A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Prostate Adenocarcinoma

A prostatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Breast Carcinoma

A breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Unresectable Castration-Resistant Prostate Carcinoma

Castration-resistant prostate carcinoma that is not amenable to surgical resection.


Locally Advanced Unresectable Renal Cell Carcinoma

A renal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable HER2-Negative Breast Carcinoma

HER2-negative breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Cervical Adenocarcinoma

A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Lung Non-Small Cell Squamous Carcinoma

A non-small cell squamous carcinoma of the lung that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable HER2-Positive Breast Carcinoma

HER2-positive breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Fallopian Tube Carcinoma

Fallopian tube carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma

Hormone receptor-positive breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Prostate Carcinoma

A prostatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Cervical Carcinoma

A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Stage IA Uterine Sarcoma AJCC v7

Stage IA includes: T1a, N0, M0.  T1a: For leiomyosarcoma and endometrial stromal sarcoma: tumor 5 cm or less in greatest dimension.  For adenosarcoma: tumor limited to endometrium/endocervix.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis.


negative regulation of planar cell polarity pathway involved in heart morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis.


negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis.


negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis.


negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis.


negative regulation of planar cell polarity pathway involved in pericardium morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis.


P2Y5 nucleotide receptor binding

Binding to a P2Y5 nucleotide receptor.


tonsil neoplasm

A neoplasm (disease) that involves the tonsil.


benign neoplasm of tonsil

A benign neoplasm that involves the tonsil.


tonsillar lipoma

A benign adipose tissue neoplasm of the tonsils.


cystic vein

A blood vessel carrying deoxygenated blood from the gallbladder and the cystic duct into the right branch of the portal vein.


formamide biosynthetic process

The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid.


D-tagatose 6-phosphate metabolic process

The chemical reactions and pathways involving a D-tagatose 6-phosphate.


Eccrine angiomatous hamartoma

A rare, congenital skin lesion consisting of a proliferation of eccrine glands with a vascular stroma. It presents as a flesh-colored, hyperhidrotic, painful papule or plaque appearing at birth or during childhood.


peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine

The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine.


plantar fibromatosis

A superficial fibromatosis arising from soft tissue of the plantar regions. It is characterized by the presence of spindle-shaped fibroblasts, hypercellularity, and an infiltrative growth pattern.


lateral mesoderm morphogenesis

The process in which the anatomical structures of the lateral mesoderm are generated and organized.


succinate-CoA ligase complex (GDP-forming)

A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.


mitochondrial isocitrate dehydrogenase complex (NAD+)

Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity.


mitochondrial oxoglutarate dehydrogenase complex

A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus.


Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O.


regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


regulation of heterochromatin formation

Any process that modulates the frequency, rate, extent or location of heterochromatin formation.


positive regulation of mating-type specific transcription, DNA-templated

Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription.


regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts

Any process that modulates the rate, frequency, or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein.


siRNA-mediated gene silencing by mRNA destabilization

An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.


regulation of ncRNA transcription

Any process that modulates the frequency, rate or extent of transcription of a non-protein coding gene from a DNA-template.


regulation of ethylene biosynthetic process

Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process.


positive regulation of cellular biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.


negative regulation of methyl-branched fatty acid biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of methyl-branched fatty acid biosynthetic process.


regulation of reticulophagy

Any process that modulates the frequency, rate or extent of reticulophagy.


regulation of mitotic cell cycle DNA replication

Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication.


regulation of antibacterial peptide secretion

Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion.


regulation of antifungal peptide secretion

Any process that modulates the frequency, rate, or extent of antifungal peptide secretion.


negative regulation of interleukin-1 alpha production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production.


negative regulation of carotenoid biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of carotenoid biosynthetic process.


positive regulation of vitamin E biosynthetic process

Any process that activates or increases the frequency, rate or extent of vitamin E biosynthetic process.


negative regulation of macrophage colony-stimulating factor production

Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor production.


regulation of cell wall (1->3)-beta-D-glucan biosynthetic process

Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells.


symbiont-mediated suppression of host gene expression

A process in which a symbiont inhibits or disrupts expression of genes in its host. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. The host is defined as the larger of the organisms involved in a symbiotic interaction.


programmed DNA elimination by elimination of internal DNA segments

A programmed DNA elimination mechanism in which specific sequences, namely, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the genome. This process is known to occur in ciliates.


negative regulation of interleukin-37 production

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 production.


transitive RNA interference

An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence.


epigenetic programming in the central cell

The establishment of epigenetic modifications (imprints) in a plant central cell, leading to an asymmetry between the two maternal alleles and the paternal allele, and differential expression of the corresponding alleles in the developing endosperm. This can happen through heterochromatin formation or differential chromatin loop formation.


regulation of phosphatidylserine metabolic process

Any process that modulates the frequency, rate or extent of phosphatidylserine metabolic process.


regulation of aggrephagy

Any process that modulates the frequency, rate or extent of aggrephagy.


positive regulation of methane biosynthetic process from trimethylamine

Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from trimethylamine.


regulation of restriction endodeoxyribonuclease activity

Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.


nitrogen catabolite regulation of transcription

A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


regulation of ent-pimara-8(14),15-diene biosynthetic process

Any process that modulates the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process.


positive regulation of interleukin-21 production

Any process that activates or increases the frequency, rate, or extent of interleukin-21 production.


regulation of siRNA-mediated facultative heterochromatin formation

Any process that modulates the frequency, rate or extent of siRNA-dependent facultative heterochromatin formation.


negative regulation of interleukin-26 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production.


positive regulation of chlorophyll catabolic process

Any process that activates or increases the frequency, rate or extent of chlorophyll catabolic process.


negative regulation of (+)-kotanin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of (+)-kotanin biosynthetic process.


symbiont-mediated suppression of host PKR/eIFalpha signaling

A process in which a symbiont inhibits or disrupts a host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


regulation of interleukin-34 production

Any process that modulates the frequency, rate or extent of interleukin-34 production.


regulation of error-prone translesion synthesis

Any process that modulates the frequency, rate or extent of error-prone translesion synthesis.


siRNA-mediated facultative heterochromatin formation

The formation of facultative heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a small interfering RNA.


positive regulation of macromolecule biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


negative regulation of violaceol II biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of violaceol II biosynthetic process.


regulation of violaceol I biosynthetic process

Any process that modulates the frequency, rate or extent of violaceol I biosynthetic process.


regulation of cytochrome-c oxidase activity

Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity.


positive regulation of (1->3)-beta-D-glucan biosynthetic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans.


positive regulation of diacylglycerol kinase activity

Any process that activates or increases the frequency, rate or extent of diacylglycerol kinase activity.


negative regulation of chemokine (C-X-C motif) ligand 1 production

Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production.


nitrogen catabolite activation of transcription

A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


tRNA destabilization

Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes.


induction by virus of host autophagy

Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.


regulation of mitochondrial ATP synthesis coupled electron transport

Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport.


positive regulation of glycolytic process through fructose-6-phosphate

Any process that activates or increases the frequency, rate or extent of glycolytic process through fructose-6-phosphate.


regulation of interleukin-15 production

Any process that modulates the frequency, rate, or extent of interleukin-15 production.


silent mating-type cassette heterochromatin formation

Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.


negative regulation of transforming growth factor beta3 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3.


regulation of RNA polymerase III activity

Any process that modulates the frequency, rate or extent of RNA polymerase III activity.


regulation of regulatory ncRNA-mediated heterochromatin formation

Any process that modulates the frequency, rate or extent of small non-coding RNA-mediated heterochromatin formation.


positive regulation of hydrogen peroxide biosynthetic process

Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.


regulation of type III site-specific deoxyribonuclease activity

Any process that modulates the frequency, rate or extent of a type III restriction endodeoxyribonuclease activity.


negative regulation of natural killer cell cytokine production

Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production.


regulation of vitamin A metabolic process

Any process that modulates the frequency, rate or extent of vitamin A metabolic process.


regulation of amylopectin catabolic process

Any process that modulates the frequency, rate or extent of amylopectin catabolic process.


positive regulation of telomere maintenance in response to DNA damage

Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage.


positive regulation of antimicrobial peptide secretion

Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion.


positive regulation of juvenile hormone catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone.


positive regulation of myeloid dendritic cell cytokine production

Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.


regulation of interleukin-11 production

Any process that modulates the frequency, rate, or extent of interleukin-11 production.


negative regulation of interleukin-34 production

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production.


regulation of pectin biosynthetic process

Any process that modulates the frequency, rate or extent of pectin biosynthetic process.


negative regulation of cellular metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


regulation of interleukin-33 production

Any process that modulates the frequency, rate or extent of interleukin-33 production.


regulation of chemokine (C-C motif) ligand 4 production

Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4.


regulation of interleukin-37 production

Any process that modulates the frequency, rate or extent of interleukin-37 production.


positive regulation of type III interferon production

Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.


negative regulation of syringal lignin catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin catabolic process.


positive regulation of chemokine (C-C motif) ligand 1 production

Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1.


negative regulation of interleukin-16 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production.


regulation of 4,6-pyruvylated galactose residue biosynthetic process

Any process that modulates the rate, frequency, or extent of 4,6-pyruvylated galactose residue biosynthetic process, the chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-(1->3)-. The galactose residue is part of a larger polysaccharide chain.


lncRNA-mediated post-transcriptional gene silencing

A post-transcriptional gene silencing pathway in which regulatory long noncoding RNAs (lncRNAs) elicit silencing of specific target genes, often miRNAs or mRNAs.


positive regulation of ergosterol biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.


positive regulation of aggrephagy

Any process that activates or increases the frequency, rate or extent of aggrephagy.


siRNA-mediated long-distance post-transcriptional gene silencing

An siRNA-mediated posttranscriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs, and in which the silencing signal originates in one tissue and occurs in a different tissue.


negative regulation of cardiolipin metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of cardiolipin metabolic process.


positive regulation of 3'-UTR-mediated mRNA stabilization

Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.


regulation of cell wall chitin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin.


regulation of DNA strand resection involved in replication fork processing

Any process that modulates the frequency, rate or extent of DNA strand resection involved in replication fork processing.


positive regulation of bile acid metabolic process

Any process that activates or increases the frequency, rate or extent of bile acid metabolic process.


regulation of pyrimidine nucleotide biosynthetic process

Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthetic process.


regulation of siRNA processing

Any process that modulates the frequency, rate or extent of siRNA processing.


negative regulation of UDP-glucose catabolic process

Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.


regulation of double-strand break repair via break-induced replication

Any process that modulates the frequency, rate or extent of double-strand break repair via break-induced replication.


positive regulation of interleukin-7 production

Any process that activates or increases the frequency, rate, or extent of interleukin-7 production.


negative regulation of interleukin-20 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production.


negative regulation of interleukin-24 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production.


positive regulation of single strand break repair

Any process that activates or increases the frequency, rate or extent of single strand break repair.


positive regulation of post-transcriptional gene silencing by RNA

Any process that activates or increases the frequency, rate or extent of post-transcriptional gene silencing by RNA.


negative regulation of sarcinapterin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin biosynthetic process.


piRNA-mediated retrotransposon silencing by heterochromatin formation

A retrotransposon silencing mechanism in which a piRNA triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.


regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.


positive regulation of fractalkine production

Any process that activates or increases the frequency, rate, or extent of fractalkine production.


negative regulation of cytochrome-c oxidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of cytochrome-c oxidase activity.


regulation of lignin biosynthetic process

Any process that modulates the frequency, rate or extent of lignin biosynthetic process.


regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process

Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process.


regulation of toluene catabolic process

Any process that modulates the frequency, rate or extent of toluene catabolic process.


regulation of antimicrobial peptide secretion

Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion.


negative regulation of granzyme A production

Any process that stops, prevents or reduces the frequency, rate or extent of granzyme A production.


positive regulation of strand invasion

Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.


negative regulation of methane biosynthetic process from trimethylamine

Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from trimethylamine.


negative regulation of beta 2 integrin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.


negative regulation of diacylglycerol kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol kinase activity.


regulation of juvenile hormone metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone.


negative regulation of reductive pentose-phosphate cycle

Any process that stops, prevents, or reduces the frequency, rate or extent of the reductive pentose-phosphate cycle.


regulation of protection from non-homologous end joining at telomere

Any process that modulates the frequency, rate or extent of protection from non-homologous end joining at telomere.


negative regulation of 3'-UTR-mediated mRNA stabilization

Any process that stops, prevents or reduces the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.


negative regulation of interleukin-3 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production.


positive regulation of isoprene metabolic process

Any process that activates or increases the frequency, rate or extent of isoprene metabolic process.


negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.


positive regulation of methane biosynthetic process from dimethyl sulfide

Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide.


negative regulation of transforming growth factor beta3 activation

Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta3 activation.


regulation of sinapate ester biosynthetic process

Any process that modulates the frequency, rate or extent of sinapate ester biosynthesis.


regulation of phosphate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.


regulation of mitotic DNA replication initiation

Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication.


negative regulation of melanization defense response

Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection.


positive regulation of interleukin-24 production

Any process that activates or increases the frequency, rate, or extent of interleukin-24 production.


positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process

Any process that activates or increases the frequency, rate or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process.