cns neuroblastoma with FOXR2 activation

A central nervous system neuroblastoma that is characterized by FOXR2 activation and that is composed of small, round cells with hyperchromatic nuclei surrounded by a clear halo.


cutaneous granular cell tumor

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A granular cell tumor that involves the zone of skin.


adult glioblastoma

A glioblastoma occurring in adults.


brain glioblastoma

A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor.


breast granular cell tumor

A usually benign neoplasm that arises from the breast. It presents as a single, firm, and painless mass. It is characterized by the presence of neoplastic cells with eosinophilic granular cytoplasm.


schwannomatosis

The least frequent form of the rare genetic disorder neurofibromatosis. It is clinically and genetically distinct from NF1 and NF2 and is characterized by the development of multiple schwannomas (nerve sheath tumors), without involvement of the vestibular nerves. NF3 develops in adulthood and is often associated with chronic pain. Dysesthesia and paresthesia may also be present. Common localizations include the spine, peripheral nerves, and the cranium.


supratentorial ependymoma

A high grade ependymoma that is located within the supratentorial brain.


adult central nervous system primitive neuroectodermal neoplasm

A central nervous system embryonal tumor, not otherwise specified that occurs in adults.


giant cell glioblastoma

A rare histological variant of glioblastoma (WHO grade IV) with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network, and a high frequency of TP53 mutations. (WHO)


pediatric supratentorial ependymoma

An ependymoma that arises from the supratentorial region of the brain and occurs during childhood.


childhood cerebral astrocytoma

An astrocytoma, without designation of benign or malignant, that is found in the supratentorial region. The infratentorial location is more common in children.


fibrillary astrocytoma

The most frequent histological variant of diffuse astrocytoma. It is predominantly composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic criterion but mitotic activity, necrosis and microvascular proliferation are absent. The occasional or regional occurrence of gemistocytic neoplastic cells is compatible with the diagnosis of fibrillary astrocytoma. (WHO)


neurilemmoma of the pleura

A schwannoma that involves the pleura.


malignant glandular tumor of peripheral nerve sheath

A variant of malignant peripheral nerve sheath tumor characterized by the presence of glandular epithelium.


adult astrocytic tumor

An astrocytic tumor occurring during adulthood. Representative examples include diffuse astrocytoma, anaplastic astrocytoma, and glioblastoma.


childhood oligodendroglioma

An oligodendroglioma that arises from the central nervous system and occurs during childhood.


granular cell tumor

An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast.


gliosarcoma

A rare histological variant of glioblastoma (WHO grade IV) characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation (WHO).


schwannoma of jugular foramen

A rare intracranial schwannoma that affects the jugular foramen.


brain astrocytoma

A astrocytoma (excluding glioblastoma) that involves the brain.


negative regulation of tyrosine 3-monooxygenase activity

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that stops, prevents or reduces the frequency, rate or extent of tyrosine 3-monooxygenase activity.


positive regulation of hippo signaling

Any process that activates or increases the frequency, rate or extent of hippo signaling.


disulfide

Compounds of structure RSSR'.


D-cystine

The D-enantiomer of cystine.


organic disulfide

Compounds of structure RSSR in which R and R' are organic groups.


positive regulation of fatty acid beta-oxidation by octopamine signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An octopamine signaling pathway that results in positive regulation of fatty acid beta-oxidation.


biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate.


Recurrent Lung Neuroendocrine Neoplasm

The reemergence of a lung neuroendocrine neoplasm after a period of remission.


benign testicular sertoli cell tumor

A non-metastasizing sex cord-stromal tumor that arises from the testis. Morphologically, it is characterized by the presence of Sertoli cells forming tubules. Leydig cells are rare or absent.


testicular sertoli cell tumor

A sex cord-stromal tumor that arises from the testis and is characterized by the presence of neoplastic cells with features of Sertoli cells. It usually presents as a slow growing testicular mass. The vast majority of cases follow a benign clinical course.


Refractory Childhood Lymphoma

Childhood Hodgkin or non-Hodgkin lymphoma that is resistant to treatment.


Refractory Childhood Hodgkin Lymphoma

Hodgkin lymphoma that occurs during childhood and is resistant to treatment.


developmental and epileptic encephalopathy, 86


Tuberculous bronchopneumonia

Acute and progressive bronchopneumonia caused by Mycobacterium tuberculosis bacteria.  It is characterized by widespread pulmonary patchy consolidations.


equatorial microtubule organizing center disassembly

The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis.


Advanced HER2-Low Breast Carcinoma

HER2-low breast adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


positive regulation of FACT complex assembly

Any process that activates or increases the frequency, rate or extent of FACT complex assembly.


combined oxidative phosphorylation defect type 30

Any combined oxidative phosphorylation deficiency in which the cause of the disease is a mutation in the TRMT10C gene.


negative regulation of neutrophil extravasation

Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil extravasation.


negative regulation of glucuronoarabinoxylan catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoarabinoxylan catabolic process.


negative regulation of glucuronoxylan catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoxylan catabolic process.


craniocervical lymph node

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Lymph node located in either head and neck region.


Ovarian Mucinous Cystic Tumor with Mural Nodules

A mucinous cystic tumor of the ovary characterized by the presence of one or more well circumscribed solid nodules in the wall of the cysts (mural nodules) that protrude into the lumen.  The mural nodules may be benign (sarcoma-like) or malignant.  The malignant mural nodules histologically are anaplastic carcinomas, carcinosarcomas, or sarcomas.  The clinical course depends on the histology of the mural nodules.  The prognosis of mucinous cystic tumors with benign mural nodules is the same as the corresponding types of mucinous cystic tumors without the mural nodules.  Mucinous cystic tumors with malignant mural nodules may follow a malignant clinical course.


Epithelioid sarcoma recurrent

The reemergence of epithelioid sarcoma after a period of remission


invasive hydatidiform mole

A complete hydatidiform mole or very rarely a partial mole that invades the myometrium.


placenta neoplasm

A neoplasm (disease) that involves the placenta.


Metastatic Neoplasm to the Placenta

A malignant neoplasm that has spread to the placenta from another anatomic site.


Placental polyp

A polyp in the uterine cavity that is formed by placenta remnants.


placental choriocarcinoma

Choriocarcinoma that develops in the placenta. It is the rarest form of gestational choriocarcinoma. Metastases to the mother and infant may occur.


benign neoplasm of placenta

A benign neoplasm that involves the placenta.


placenta cancer

A malignant neoplasm involving the placenta.


Metastatic Hydatidiform Mole

The spread of abnormal molar chorionic villi from an invasive hydatidiform mole in the uterine cavity to other anatomic sites, usually the vaginal wall and pelvis.


G protein-coupled acetylcholine receptor signaling pathway involved in heart process

A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart.


postsynaptic signal transduction

Signal transduction in which the initial step occurs in a postsynapse.


positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate.


G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate.


acetylcholine receptor signaling pathway

The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands.


G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission

Any G protein-coupled acetylcholine receptor signaling pathway that is involved in positive regulation of acetylcholine secretion, neurotransmission.


imaginal disc-derived female genitalia morphogenesis

The process in which the anatomical structures of female genitalia are generated and organized from the genital disc.


protein localization to linear element

A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase.


protein localization to nucleolar rDNA repeats

Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus.


protein localization to heterochromatin

Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin.


protein localization to condensed nuclear chromosome

A process in which a protein is transported to, or maintained in, a location within a condensed nuclear chromosome.


Bub1-Bub3 complex localization to kinetochore

A cellular protein complex localization that acts on a Bub1-Bub3 complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore.


CLRC complex localization to heterochromatin

The process by which a CLRC complex is transported to, or maintained in, heterochromatin. CLRC complex is an active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation.


protein localization to kinetochore involved in kinetochore assembly

Any protein localization to kinetochore that is involved in kinetochore assembly.


protein localization to subtelomeric heterochromatin

A process in which a protein is transported to, or maintained in, a location within a subtelomeric heterochromatin.


protein localization to CENP-A containing chromatin

Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin.


protein localization to euchromatin

A process in which a protein is transported to, or maintained in, a location within an euchromatin.


protein localization to condensed chromosome

A process in which a protein is transported to, or maintained in, a location within a condensed chromosome.


protein localization to mating-type region heterochromatin

A process in which a protein is transported to, or maintained in, a location within a mating-type region heterochromatin.


establishment of protein localization to euchromatin

The directed movement of a protein to a specific location in an euchromatin.


protein localization to pericentric heterochromatin

A process in which a protein is transported to, or maintained in the pericentric heterochromatin.


catalase complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A protein-containing complex that is capable of catalase activity.


autosomal recessive limb-girdle muscular dystrophy type 2B

Autosomal recessive limb-girdle muscular dystrophy type 2B (LGMD2B) is a subtype of autosomal recessive limb-girdle muscular dystrophy characterized by an onset in late adolescence or early adulthood of slowly progressive, proximal weakness and atrophy of shoulder and pelvic girdle muscles. Cardiac and respiratory muscles are not involved. Hypertrophy of the calf muscles and highly elevated serum creatine kinase levels are frequently observed.


Blasts Under 10,000 of Peripheral Blood White Cells

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A quantitative microscopic finding indicating that less than 10,000 of the total number of nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.


suppurative lymphadenitis

A form of lymphadenitis that is characterized by formation of pus; it is most often caused by staphylococcal or streptococcal bacteria.


pericardium cancer

A malignant neoplasm involving the pericardium.


Pericardial Sarcoma

A rare sarcoma that arises from the pericardium. The two most common types are angiosarcoma and synovial sarcoma. Patients present with symptoms related to pericardial effusion.


Pericarditis malignant

Pericarditis caused by the infiltration of the pericardium by a malignant neoplasm.  The diagnosis is based on the cytological examination of pericardial fluid or the histologic examination of pericardial tissue.


Metastatic malignant neoplasm to pericardium

A malignant neoplasm that has spread to the pericardium from another primary anatomic site.


Pericardial mesothelioma malignant recurrent

The reemergence of malignant mesothelioma in the pericardium after a period of remission.


Pericardial Primary Effusion Lymphoma

Primary effusion lymphoma that affects the pericardial cavity. The majority of patients are HIV-positive men.


Pericardial Yolk Sac Tumor

A yolk sac tumor that arises within the pericardium.


Pericardial Carcinomatosis

Carcinoma that has spread diffusely to the pericardium.


Pericardial Synovial Sarcoma

A rare synovial sarcoma that arises from the pericardium. Patients present with symptoms related to pericardial effusion.


Malignant Pericardial Germ Cell Tumor

A malignant germ cell tumor that arises within the pericardium.


Pericardial Angiosarcoma

A rare angiosarcoma that arises from the pericardium. Patients present with symptoms related to pericardial effusion.


nucleosome array spacer activity

A histone octamer slider activity that spaces nucleosomes along chromosomal DNA. This activity is involved in assembling chromatin in uniform nucleosome arrays to regulate transcription by RNA polymerases I, II, and III, as well as DNA replication, recombination and repair.


intellectual developmental disorder, X-linked, syndromic, Hackmann-Di Donato type


Finding During Childbirth Labor

Symptom, signs, test results in a pregnant mother childbirth.


Prolonged second stage of labor

At least 2 hours of pushing in multiparous women and at least 3 hours of pushing in nulliparous women. Longer durations may be appropriate on an individualized basis (e.g., with the use of epidural analgesia or with fetal malposition) as long as progress is being documented.


Arrested active phase of labor

More than or equal to 6 cm dilation with membrane rupture and one of the following: 4 hours or more of adequate contractions (e.g. more than 200 Montevideo units), 6 hours or more of inadequate contractions and no cervical change.


dTMP salvage

Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis.


purine deoxyribonucleotide salvage

Any process which produces a purine deoxyribonucleotide from derivatives of it, without de novo synthesis.


dCMP salvage

Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis.


pyrimidine deoxyribonucleotide salvage

The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis.


T-bar

A T-shaped presynpatic density. These are common in arhropod central nervous systems.


presynaptic density

An electron dense specialization of the presynaptic active zone cytoskeleton.


positive regulation terrein biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of the fungal metabolite terrein.


positive regulation of tensidol B biosynthetic process

Any process that activates or increases the frequency, rate or extent of tensidol B biosynthetic process.


positive regulation of patulin biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of patulin.


positive regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process

Any process that activates or increases the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process.


positive regulation of helvolic acid biosynthetic process

Any process that activates or increases the frequency, rate or extent of helvolic acid biosynthetic process.


positive regulation of emericellamide biosynthetic process

Any process that activates or increases the frequency, rate or extent of emericellamide biosynthetic process.


positive regulation of violaceol II biosynthetic process

Any process that activates or increases the frequency, rate or extent of violaceol II biosynthetic process.


positive regulation of gliotoxin biosynthetic process

Any process that activates or increases the frequency, rate or extent of gliotoxin biosynthetic process.


positive regulation of F-9775B biosynthetic process

Any process that activates or increases the frequency, rate or extent of F-9775B biosynthetic process.


positive regulation of F-9775A biosynthetic process

Any process that activates or increases the frequency, rate or extent of F-9775A biosynthetic process.


positive regulation of demethylkotanin biosynthetic process

Any process that activates or increases the frequency, rate or extent of demethylkotanin biosynthetic process.


positive regulation of emericellin biosynthetic process

Any process that activates or increases the frequency, rate or extent of emericellin biosynthetic process.


positive regulation of fumonisin biosynthetic process

Any process that activates or increases the frequency, rate or extent of fumonisin biosynthetic process.


positive regulation of chanoclavine-I aldehyde biosynthetic process

Any process that activates or increases the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process.


positive regulation of arugosin biosynthetic process

Any process that activates or increases the frequency, rate or extent of arugosin biosynthetic process.


positive regulation of asperfuranone biosynthetic process

Any process that activates or increases the frequency, rate or extent of asperfuranone biosynthetic process.


positive regulation of diorcinol biosynthetic process

Any process that activates or increases the frequency, rate or extent of diorcinol biosynthetic process.


positive regulation of o-orsellinic acid biosynthetic process

Any process that activates or increases the frequency, rate or extent of o-orsellinic acid biosynthetic process.


positive regulation of orcinol biosynthetic process

Any process that activates or increases the frequency, rate or extent of orcinol biosynthetic process.


positive regulation of terrequinone A biosynthetic process

Any process that activates or increases the frequency, rate or extent of terrequinone A biosynthetic process.


positive regulation of (+)-kotanin biosynthetic process

Any process that activates or increases the frequency, rate or extent of (+)-kotanin biosynthetic process.


positive regulation of tensidol A biosynthetic process

Any process that activates or increases the frequency, rate or extent of tensidol A biosynthetic process.


positive regulation of dehydroaustinol biosynthetic process

Any process that activates or increases the frequency, rate or extent of dehydroaustinol biosynthetic process.


positive regulation of endocrocin biosynthetic process

Any process that activates or increases the frequency, rate or extent of endocrocin biosynthetic process.


positive regulation of ferrichrome biosynthetic process

Any process that activates or increases the frequency, rate or extent of ferrichrome biosynthetic process.


positive regulation of lovastatin biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of lovastin.


positive regulation of monodictyphenone biosynthetic process

Any process that activates or increases the frequency, rate or extent of monodictyphenone biosynthetic process.


positive regulation of polyketide biosynthetic process

Any process that activates or increases the frequency, rate or extent of polyketide biosynthetic process.


positive regulation of asperthecin biosynthetic process

Any process that activates or increases the frequency, rate or extent of asperthecin biosynthetic process.


positive regulation of ergot alkaloid biosynthetic process

Any process that activates or increases the frequency, rate or extent of ergot alkaloid biosynthetic process.


positive regulation of siderophore biosynthetic process

Any process that activates or increases the frequency, rate or extent of siderophore biosynthetic process.


positive regulation of cordyol C biosynthetic process

Any process that activates or increases the frequency, rate or extent of cordyol C biosynthetic process.


positive regulation of emodin biosynthetic process

Any process that activates or increases the frequency, rate or extent of emodin biosynthetic process.


positive regulation of fumigaclavine C biosynthetic process

Any process that activates or increases the frequency, rate or extent of fumigaclavine C biosynthetic process.


positive regulation of emericellamide A biosynthetic process

Any process that activates or increases the frequency, rate or extent of emericellamide A biosynthetic process.


positive regulation of gerfelin biosynthetic process

Any process that activates or increases the frequency, rate or extent of gerfelin biosynthetic process.


positive regulation of penicillin biosynthetic process

Any process that activates or increases the frequency, rate or extent of penicillin biosynthetic process.


positive regulation of syringal lignin biosynthetic process

Any process that activates or increases the frequency, rate or extent of syringal lignin biosynthetic process.


positive regulation of neosartoricin biosynthetic process

Any process that activates or increases the frequency, rate or extent of neosartoricin biosynthetic process.


positive regulation of aflatoxin biosynthetic process

Any process that activates or increases the frequency, rate or extent of aflatoxin biosynthetic process.


positive regulation of sterigmatocystin biosynthetic process

Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.


Bladder carcinoma stage I, without cancer in situ

Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Bladder Cancer by AJCC v7 Stage

A term that refers to the staging of bladder cancer according to the American Joint Committee on Cancer, 7th edition.


Bladder squamous cell carcinoma stage 0

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Bladder transitional cell carcinoma stage II

Stage II includes: (T2a, N0, M0); (T2b, N0, M0).  T2a: Tumor invades superficial muscle (inner half).  T2b: Tumor invades deep muscle (outer half).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Stage 0a Bladder Urothelial Carcinoma AJCC v6 and v7

Stage 0a includes: Ta, N0, M0. Ta: Papillary noninvasive carcinoma.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage III Bladder Cancer AJCC v6 and v7

Stage III includes: (T3a, N0, M0); (T3b, N0, M0); (T4a, N0, M0).  T3a: Tumor microscopically invades perivesical tissue.  T3b: Tumor macroscopically invades perivesical tissue (extravesical mass).  T4a: Tumor invades prostatic stroma, uterus, vagina.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Bladder carcinoma stage I, with cancer in situ

Stage I bladder carcinoma associated with the presence of bladder carcinoma in situ.


Stage IV Bladder Cancer AJCC v7

Stage IV includes: (T4b, N0, M0); (Any T, N1-3, M0); (Any T, Any N, M1).  T4b: Tumor invades pelvic wall, abdominal wall.  N0: No regional lymph node metastasis.  N1: Single regional lymph node metastasis in the true pelvis (hypogastric, obturator, external iliac, or presacral lymph node).  N2: Multiple regional lymph node metastases in the true pelvis (hypogastric, obturator, external iliac, or presacral lymph node metastasis).  N3: Metastasis to the common iliac lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Bladder transitional cell carcinoma stage III


Bladder squamous cell carcinoma stage III


Bladder adenocarcinoma stage II

Stage II includes: (T2a, N0, M0); (T2b, N0, M0).  T2a: Tumor invades superficial muscle (inner half).  T2b: Tumor invades deep muscle (outer half).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Bladder transitional cell carcinoma stage IV


Bladder squamous cell carcinoma stage IV


Bladder transitional cell carcinoma stage I


Stage 0 Bladder Carcinoma

Stage 0 includes: 0a (Ta, N0, M0); 0is (Tis, N0, M0).  Ta: Noninvasive papillary carcinoma. Tis: Carcinoma in situ: "flat tumor".  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Refractory Stage 0 Bladder Cancer AJCC v6 and v7

Stage 0 bladder cancer defined according to the AJCC v6 and v7 criteria that is resistant to treatment.


Bladder squamous cell carcinoma stage II


lipoprotein localization to outer membrane

A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane.


Advanced Undifferentiated Pleomorphic Sarcoma

An undifferentiated pleomorphic sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


interphalangeal joint of manual digit 4

An interphalangeal joint of manus that is part of a manual digit 4.


distal interphalangeal joint of manual digit 4


positive regulation of testosterone secretion

Any process that activates or increases the frequency, rate or extent of testosterone secretion.


positive regulation of imaginal disc growth

Any process that activates or increases the frequency, rate or extent of imaginal disc growth.


Superficial injury of abdomen, lower back and pelvis, part unspecified

An injury to the soft tissues overlying the abdomen, lower back or pelvis.


funisitis

An acute inflammation of the umbilical cord. It is characterized by the presence of polymorphonuclear cells migrating from the fetal umbilical cord vessels through the umbilical cord towards the bacteria containing amniotic fluid.


Necrotizing Funisitis

A ring of karyorrhectic debris that may exhibit dystrophic mineralization and/or identifiable fetal neutrophil infiltrate in Wharton's jelly that is oriented towards the amniotic surface. The cord has a denser ring externally and a fainter ring centrally.


Non-Functioning Pancreatic Neuroendocrine Tumor G2

An intermediate grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. It is characterized by the absence of a hormone-related clinical syndrome.


Pancreatic Neuroendocrine Tumor G2

An intermediate grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3-20%.


Advanced Pancreatic Neuroendocrine Tumor G2

Pancreatic neuroendocrine tumor G2 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Functioning Pancreatic Neuroendocrine Tumor G2

An intermediate grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of a clinical syndrome that results from hormone hypersecretion.


Metastatic Pancreatic Neuroendocrine Tumor G2

Pancreatic neuroendocrine tumor G2 that has spread from its original site of growth to another anatomic site.


autoimmune disorder of endocrine system

A hypersensitivity reaction type II disease that involves the endocrine system.


adenohypophysitis

An autoimmune disease of the pituitary gland which can present with varying degrees of pituitary hormonal impairment and/or with symptoms related to pituitary enlargement. It predominantly affects young women in pregnancy or the peripartum period.


autoimmune oophoritis

Autoimmune oophoritis is a rare cause of primary ovarian insufficiency (POI). It happens when the body's immune system mistakenly attacks the ovaries causing inflammation, atrophy and fibrosis. These changes stop the ovaries from working normally. The main symptoms of autoimmune oophorotis are irregular or absent menstrual period (amenorrhea) and symptoms related to ovarian cysts such as abdominal cramping, bloating, nausea and vomiting. Autoimmune oophoritis may occur as part of autoimmune polyglandular syndrome type I and type II but has also been associated with lupus, pernicious anemia, myasthenia gravis and other autoimmune conditions. The underlying cause of autoimmune oophoritis is unknown. Diagnosis involves a special blood test which looks for anti-steroid or anti-ovarian antibodies, a pelvic ultrasound to look for enlarged cystic ovaries and tests to rule out other possible causes of POI. Management of autoimmune oophoritis involves emotional support, possible estrogen replacement therapy and management of other autoimmune conditions.


atrophic thyroiditis

Atrophic thyroiditis is an organ-specific autoimmune disease characterized by thyroid autoantibodies, functional hypothyroidism, and absence of goiter.


primary hypophysitis

Immune-mediated inflammation of the pituitary gland often associated with other autoimmune diseases (e.g., hashimoto disease; graves disease; and addison disease).


autoimmune primary ovarian failure

An autoimmune form of primary ovarian failure.


postpartum thyroiditis

A transient autoimmune Inflammatory disorder of thyroid gland that occurs postpartum due to any partum problem. It is characterized by the presence of high titers of autoantibodies against thyroid peroxidase and thyroglobulin. Clinical signs include the triphasic thyroid hormone pattern: beginning with thyrotoxicosis, followed with hypothyroidism, then return to euthyroid state by 1 year postpartum


IgG4-related thyroid disease

Riedel thyroiditis is a fibroinflammatory disorder of the thyroid gland, occuring more frequently in females, characterized a large, hard thyroid mass, and presenting with pressure symptoms (breathing difficulB,ties and dysphagia) or voice hoarseness and aphonia (impingement of recurrent laryngeal nerve). It can often be associated with extracervical fibroinflammatory disorders such as retroperitoneal fibrosis, primary scleroisng cholangitis and autoimmune diseases such as Hashimoto struma, Addison disease, and Biermer disease.


autoimmune polyendocrinopathy

A group of diverse conditions that are characterized by spontaneous, multi-organ autoimmunity, which target both endocrine (adrenal, gonad, pancreatic islet cells, parathyroid, pituitary, thyroid) and non-endocrine (gastrointestinal, integumentary, lymphatic) tissues.


autoimmune thyroid disease

Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.


neonatal thyrotoxicosis

A hypermetabolic syndrome characterized by tachycardia, palpitations, tremor, weight loss, and moist skin that is caused by the elevation of thyroid hormone levels in the serum of the newborn infant or thyroid-axis receptor activation, most commonly due to transplacental passage of thyroid stimulating globulins.


autoimmune polyendocrinopathy type 2

Autoimmune polyglandular syndrome of likely polygenic etiology characterized by the presence of primary adrenal insufficiency in association with autoimmune thyroiditis and/or type 1 diabetes mellitus; this condition is not associated with mucocutaneous candidiasis.


autoimmune polyendocrine syndrome type 1

Autoimmune polyendocrinopathy type 1, or APECED syndrome, is a genetic disease that manifests in childhood or early adolescence with a combination of chronic mucocutaneous candidiasis, hypoparathyroidism and autoimmune adrenal failure.


autoimmune polyendocrinopathy type 3

A rare, endocrine disease characterized by autoimmune thyroid disease associated with at least one other autoimmune disease, such as type I diabetes mellitus, chronic atrophic gastritis, pernicious anemia, vitiligo, alopecia, or myasthenia gravis, but excluding Addison disease.


phosphosulfolactate synthase activity

Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite.


vesicle scission involved in endocytosis

The membrane scission process that is the final step in the formation of an endocytic vesicle: separation from the plasma membrane.


vesicle scission involved in clathrin-mediated endocytosis

The membrane scission process that is the final step in the formation of a clathrin-coated endocytic vesicle: separation from the plasma membrane.


methyl tertiary butyl ether 3-monooxygenase activity

Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde.


scopolamine biosynthetic process

The chemical reactions and pathways resulting in the formation of scopolamine.


abediterol

A quinolone that is 8-hydroxyquinolin-2(1H)-one which carries a 2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl group at position 5. It is a long acting beta2-adrenoceptor agonist currently in development for the treatment of chronic obstructive pulmonary disease (COPD) and asthma.


epithelium of handplate

An epithelium that is part of a handplate.


AV Block First Degree by ECG Finding

An electrocardiographic finding of prolonged PR interval for a specific population. For adults one common threshold is a PR interval greater than 0.20 seconds. Note that other thresholds may be applicable. (CDISC)


Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate.


positive regulation of cGMP-mediated signaling

Any process that increases the rate, frequency or extent of cGMP-mediated signaling.


symbiont-mediated perturbation of host cGMP-mediated signal transduction

A process in which a symbiont alters or subverts a cGMP-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


negative regulation of cGMP-mediated signaling

Any process that decreases the rate, frequency or extent of cGMP-mediated signaling.


Unresectable NUT Carcinoma

NUT carcinoma that is not amenable to surgical resection.


A53 Diffuse Large B-Cell Lymphoma

A genetic subtype of diffuse large B-cell lymphoma characterized by TP53 gene mutations and deletions that is often accompanied by aneuploidy.


spindle cell nevus

A nevus characterized by the presence of spindle-shaped melanocytes.


Childhood Recurrent Malignant Solid Neoplasm

The reemergence of a childhood malignant solid neoplasm after a period of remission.


amelogenesis imperfecta type 2A1

Any amelogenesis imperfecta in which the cause of the disease is a mutation in the KLK4 gene.


thoracic vertebra 7

The seventh thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].


Pelvic Floor Muscle Weakness

A reduction in the strength of the muscles of the pelvic floor.


phosphoglycerate dehydrogenase activity

Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.


specific developmental disorder

A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.


communication disorder

A disorder characterized by an individual's inability to comprehend or share ideas or feelings because of an impairment in language, speech, or hearing.


attention deficit-hyperactivity disorder 8


specific language impairment

A language disorder characterized by difficulty in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors.


mixed receptive-expressive language disorder

A disorder characterized by an impairment in the development of an individual's expressive and receptive language capabilities which is in contrast to his/her nonverbal intellect. The impairment may be acquired (i.e., due to a brain lesion or head trauma) or developmental (i.e., no known neurological insult).


transient tic disorder

A neurological disorder presenting in childhood that is characterized by motor and/or phonic tics that occur daily or nearly daily for one to twelve months and are not attributed to an identifiable cause.


articulation disorder

A disorder characterized by the failure to use developmentally expected speech sounds that are appropriate for the individual's age (i.e., the individual makes errors in sound production or use or omits sounds such as final consonants).


partial fetal alcohol syndrome

A fetal alcohol spectrum disorder that results in most, but not all, of the growth deficiency and/or craniofacial features of fetal alcohol syndrome including central nervous system dysfunction due to prenatal alcohol exposure.


dysgraphia

Loss or impairment of the ability to write (letters, syllables, words, or phrases) due to an injury to a specific cerebral area or occasionally due to emotional factors. This condition rarely occurs in isolation, and often accompanies aphasia. (From Adams et al., Principles of Neurology, 6th ed, p485; apa, Thesaurus of Psychological Index Terms, 1994)


specific language impairment 5

A communication disorder that involves the processing of linguistic information.


dyslexia

A learning disorder characterized by an impairment in processing written words. Reading difficulties can include distortions, omissions or substitutions of characters. Oral and silent reading difficulties can include faulty and slow comprehension.


A disorder characterized by a marked pattern of inattention and/or hyperactivity-impulsivity that is inconsistent with developmental level and clearly interferes with functioning in at least two settings (e.g. at home and at school). When present, the symptoms of hyperactivity are most often present before the age of 7 years. There are three recognized presentations or subtypes from most to least common: combined type, inattentive/distractible type, hyperactive/impulsive type.


fetal nicotine spectrum disorder

A specific developmental disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of nicotine during pregnancy.


writing disorder

A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition.


chronic tic disorder

A neurological disorder presenting in childhood that is characterized by either motor or phonic tics, but not both, that occur daily or nearly daily for at least a year and are not attributed to an identifiable cause.


alcohol-related birth defect

A physical or cognitive mental abnormality caused by maternal alcohol consumption and its toxic effect on the developing embryo during pregnancy.


fetal alcohol spectrum disorder

A group of disorders caused by a prenatal exposure to maternal consumption of alcohol leading to a range of behavioral, cognitive and neurological deficits in the offspring. It is characterized by physical growth problems, distinct facies, and varying psycho-neurological issues.


hereditary attention deficit-hyperactivity disorder

An instance of attention deficit-hyperactivity disorder that is caused by an inherited genomic modification in an individual.


neurobehavioral disorder with prenatal alcohol exposure

A fetal alcohol spectrum disorder that is characterized by one or more deficits in neurocognition and in self-regulation plus two or more deficits in adaptive functioning, with at least 1 in communication or social communication and interaction.


inguinal mammary gland

A mammary gland that is part of a inguinal part of abdomen.


cervical mammary gland

A mammary gland that is part of a cervical region.


thoracic mammary gland

A lactiferous gland that is located in the thoracic region/breast.


abdominal mammary gland

A lactiferous gland that is part of the abdominal region [Automatically generated definition].


EP1 subtype prostaglandin E2 receptor binding

Binding to an EP1 subtype prostaglandin E2 receptor.


Testicular Mixed Embryonal Carcinoma and Yolk Sac Tumor with Seminoma

A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of embryonal carcinoma, yolk sac, and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


Refractory Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma

Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma that is resistant to treatment.


Stage III Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

Tumors (extranodal) or nodal areas on both sides (above and below) of the diaphragm or any primary intrathoracic tumors (mediastinal, hilar, pulmonary, pleural, or thymic) or extensive (unresectable) primary intra-abdominal disease or any paraspinal or epidural tumors regardless of other tumor sites. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Lugano Classification Advanced Stage Adult Non-Hodgkin Lymphoma AJCC v8

Advanced stage adult non-Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Advanced Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage I Diffuse Large B-Cell Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Helicobacter Pylori-Associated Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

A low grade, indolent B-cell lymphoma that is associated with Helicobacter pylori infection.


Intestinal T-cell lymphoma recurrent

The reemergence of enteropathy-associated T-cell lymphoma after a period of remission.


Adult T-Cell Leukemia/Lymphoma by Ann Arbor Stage

An anatomic stage for adult T-cell leukemia/lymphoma based on the Ann Arbor classification criteria.


Mycosis Fungoides and Sezary Syndrome by AJCC v7 Stage

A term that refers to the staging of mycosis fungoides and Sezary syndrome, following the rules of the TNM AJCC v7 classification system.


Primary Cutaneous B-Cell Non-Hodgkin Lymphoma

A B-cell non-Hodgkin lymphoma arising from the skin.  Representative examples include cutaneous marginal zone B-cell lymphoma and cutaneous follicle center lymphoma.


Refractory EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

EBV-positive diffuse large B-cell lymphoma, not otherwise specified that is resistant to treatment.


Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Negative

An anaplastic large cell lymphoma, ALK-negative, arising from the central nervous system.


Stage IV Childhood Lymphoblastic Lymphoma

Stage IV: Tumors involve bone marrow and/or central nervous system (CNS) regardless of other sites of involvement (from PDQ).


Stage IVA1 Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IVA1 includes: T1-4, N0-2, M0, B2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


Adult Burkitt Lymphoma

A Burkitt lymphoma occurring in adults.


Advanced Follicular Lymphoma

Follicular lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Transformed Mycosis Fungoides

The reemergence of transformed mycosis fungoides after a period of remission.


Grade 1 Cutaneous Follicular Lymphoma

A cutaneous lymphoma which contains up to 5 centroblasts per 40X high-power microscopic field.


Recurrent Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

The reemergence of diffuse large B-cell lymphoma associated with chronic inflammation after a period of remission.


Primary mediastinal large B-cell lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Centroblastic lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


Recurrent Breast Implant-Associated Anaplastic Large Cell Lymphoma

The reemergence of breast implant-associated anaplastic large cell lymphoma after a period of remission.


Primary Cutaneous Non-Hodgkin Lymphoma

A B-or T-cell non-Hodgkin lymphoma arising in the skin.


Lugano Classification Stage II Adult Non-Hodgkin Lymphoma AJCC v8

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Lung Intravascular Large B-Cell Lymphoma

An aggressive extranodal B-cell non-Hodgkin lymphoma that affects the lung.  It is characterized by the presence of large neoplastic lymphocytes exclusively in the lumina of small vessels, particularly capillaries.


Transformed Mycosis Fungoides

Histologic transformation of mycosis fungoides to an aggressive non-Hodgkin lymphoma.


Adult Lymphoblastic Lymphoma

A lymphoblastic lymphoma occurring in adults.


Mycosis fungoides/Sezary syndrome stage I

Stage I includes: IA (T1, N0, M0, B0-1); IB (T2, N0, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Ann Arbor Stage II Subdiaphragmatic Nodular Lymphocyte Predominant Hodgkin Lymphoma


Refractory High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements

High-grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements that is resistant to treatment.


Ann Arbor Stage IV Grade 2 Follicular Lymphoma


grade 3A follicular lymphoma

A grade 3 follicular lymphoma in which centrocytes are present.


Refractory Grade 1 Follicular Lymphoma

Grade 1 follicular lymphoma that is resistant to treatment.


Refractory Primary Vitreoretinal Non-Hodgkin Lymphoma

Primary vitreoretinal non-Hodgkin lymphoma that does not respond to treatment.


Recurrent Adult Immunoblastic Lymphoma

The reemergence of adult immunoblastic lymphoma after a period of remission.


Follicle center lymphoma, follicular grade I, II, III stage IV


Childhood Primary Cutaneous Anaplastic Large Cell Lymphoma

An anaplastic large cell lymphoma that occurs during childhood and is limited to the skin at the time of diagnosis.


Follicular lymphoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Colorectal High Grade B-Cell Lymphoma, Not Otherwise Specified

High-grade B-cell lymphoma, not otherwise specified, that arises from the colorectal region.


Lymphoplasmacytic lymphoma resistant to treatment.


Indolent T-Cell Non-Hodgkin Lymphoma

A T-cell non-Hodgkin lymphoma with an indolent clinical course.


Precursor B-lymphoblastic lymphoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


non-Hodgkin's lymphoma of spleen

Non-Hodgkin lymphoma involving the spleen.


Primary Ciliary Body Non-Hodgkin Lymphoma

An extremely rare low-grade B-cell non-Hodgkin lymphoma that arises from the ciliary body. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Most cases represent extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


Mantle Cell Lymphoma with CCND3 Rearrangement

Mantle cell lymphoma characterized by the presence of CCND3 gene rearrangement. A small number of cases express this gene rearrangement and not CCND1 gene rearrangement.


Ann Arbor Stage II Grade 3 Follicular Lymphoma


Cutaneous Nasal Type Extranodal NK/T-Cell Lymphoma

Nasal type extranodal NK/T-cell lymphoma affecting the skin.


Methotrexate-Associated Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that develops in patients who are immunosuppressed with methotrexate.


Stage IIIA Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IIIA includes: T4, N0-2, M0, B0.  T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  (AJCC 7th ed.)


Recurrent Primary Cutaneous Anaplastic Large Cell Lymphoma

The reemergence of primary cutaneous anaplastic large cell lymphoma after a period of remission.


Tonsillar Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma that affects the tonsil and the bulk of the tumor is in this anatomic area.


Stage IVA Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage IVA includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.  (AJCC 7th ed.)


Burkitt's lymphoma refractory

Burkitt lymphoma that is resistant to treatment.


Extranodal Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from an anatomic site other than a lymph node.


T-cell childhood lymphoblastic lymphoma

A T lymphoblastic lymphoma that occurs during childhood.


Mycosis fungoides/Sezary syndrome

Mature T and NK neoplasms predominantly affecting the skin and the peripheral blood.  Peripheral blood involvement by abnormal T-cells (cerebriform cells) is a late manifestation of mycosis fungoides, whereas it is the presenting finding in Sezary syndrome.


Localized Anaplastic Large Cell Lymphoma

Anaplastic large cell lymphoma that is confined to a specific site without evidence of spread to other anatomic sites.


Conjunctival Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that arises from the conjunctiva.


B-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage

An anatomic stage for B-cell non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


non-Hodgkin's lymphoma of accessory sinus

A non-Hodgkin lymphoma that arises from the paranasal sinus.  Representative examples include diffuse large B-cell lymphoma and extranodal NK/T-cell lymphoma, nasal type.


Cecum Non-Hodgkin Lymphoma

An extranodal non-Hodgkin lymphoma that arises from the cecum.  The majority are B-cell non-Hodgkin lymphomas.


Cutaneous Follicular Lymphoma

A follicular lymphoma involving the skin.  A cutaneous follicular lymphoma may be metastatic to the skin from the lymph nodes or other anatomic sites or primary (cutaneous follicle center lymphoma).


Stage III Childhood Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood

Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease of childhood is a rare and very aggressive neoplastic disease emerging after a primary acute or chronic active EBV infection. It presents with persisting fever and malaise, hepatosplenomegaly with or without lymphadenopathy, liver failure, severe pancytopenia and a rapid progression towards multi-organ failure and hemophagocytic syndrome with a fatal issue. It is characterized by clonal proliferation of EBV-infected T cells with an activated cytotoxic phenotype.


Systemic Anaplastic Large Cell Lymphoma

An anaplastic large cell lymphoma that is not confined to a single anatomic site and involves multiple nodal and/or extranodal sites.


High Grade B-Cell Lymphoma with MYC and BCL6 Rearrangements

High-grade B-cell lymphoma characterized by the abnormal rearrangement of MYC and BCL6 genes.


Lacrimal System Diffuse Large B-Cell Lymphoma

A diffuse large B-cell lymphoma that arises from the lacrimal gland or the lacrimal drainage system.


Primary mediastinal large B-cell lymphoma recurrent

The reemergence of primary mediastinal large B-cell lymphoma after a period of remission.


Stage II Adult Burkitt Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Marginal zone lymphoma recurrent

The reemergence of marginal zone lymphoma after a period of remission.


Ann Arbor Stage IIX (Bulky) Diffuse Large B-Cell Lymphoma

Ann Arbor Stage II diffuse large B-cell lymphoma with a mass of nodes with one diameter more than 10cm or a mediastinal mass larger than one third of the transthoracic width. (Cotswolds modification)


Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

Histologic transformation of a marginal zone lymphoma to an aggressive diffuse large B-cell lymphoma.


Cutaneous Angioimmunoblastic T-Cell Lymphoma

Follicular helper T-cell lymphoma, angioimmunoblastic-type affecting the skin.


Diffuse follicle center lymphoma

A lymphoma with the morphologic and immunophenotypic features of a follicular lymphoma characterized by the presence of a diffuse growth pattern with only focal and usually small micronodular foci.


Stage I Adult Immunoblastic Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Intestinal T-cell lymphoma refractory

Enteropathy-associated T-cell lymphoma that is resistant to treatment.


Colorectal Mucosa-Associated Lymphoid Tissue Lymphoma

An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the colon or rectum.


Childhood EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

An EBV-positive diffuse large B-cell lymphoma, not otherwise specified, that occurs during childhood. It was originally described in patients older than 50 years, but it has been increasingly recognized in younger patients.


Ann Arbor Stage II Non-Contiguous Adult Non-Hodgkin Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

An aggressive B-cell non-Hodgkin lymphoma that is resistant to treatment.


Recurrent Aggressive T-Cell Non-Hodgkin Lymphoma

The reemergence of an aggressive T-cell non-Hodgkin lymphoma after a period of remission.


Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

An uncommon and potentially fatal diffuse large B-cell lymphoma that involves the uvea, retina, vitreous body, and optic nerve. It is a subset of primary central nervous system diffuse large B-cell lymphoma.


Stage II Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


Primary cutaneous diffuse large cell B-cell lymphoma

A diffuse large B-cell lymphoma that arises from the skin. This category includes primary cutaneous diffuse large B-cell lymphoma, leg type, and primary cutaneous diffuse large B-cell lymphoma, other, which includes primary cutaneous intravascular large B-cell lymphoma and primary cutaneous T-cell/histiocyte-rich large B-cell lymphoma.


B-cell small lymphocytic lymphoma stage I


mantle cell lymphoma of small intestine

A mantle cell lymphoma that arises from the small intestine.  It may present as an isolated mass in the small intestine or as a part of the multiple lymphomatous polyposis.


Refractory T Lymphoblastic Lymphoma

T-lymphoblastic lymphoma that does not respond to treatment.


High Grade B-Cell Lymphoma with MYC and BCL2 Rearrangements

High-grade B-cell lymphoma characterized by the abnormal rearrangement of MYC and BCL2 genes.


Recurrent Grade III Lymphomatoid Granulomatosis


Childhood Systemic Anaplastic Large Cell Lymphoma

A systemic anaplastic large cell lymphoma that occurs during childhood.


Pituitary Gland Non-Hodgkin Lymphoma

A rare non-Hodgkin lymphoma that arises from the pituitary gland. The majority are diffuse large B-cell lymphomas.


Parotid Gland Follicular Lymphoma

A follicular lymphoma that manifests initially in the parotid gland.


Recurrent ALK-Positive Large B-Cell Lymphoma

The reemergence of ALK-positive large B-cell lymphoma after a period of remission.


Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2 Stage, Tier 2

A term that refers to the staging of childhood non-Hodgkin lymphoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


Refractory High Grade B-Cell Lymphoma

High-grade B-cell lymphoma that is resistant to treatment.


Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Negative

Anaplastic large cell lymphoma, ALK-negative affecting multiple anatomic sites.


Burkitt lymphoma associated with AIDS

A Burkitt lymphoma occurring in HIV-positive patients.


MCD diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma that is categorized as MCD with high probability by the LymphGen algorithm. This is based on a combination of genetic features and MCD DLBCLs often, but do not always, have the most common hot spot mutation in MYD88 (L265P) and/or activating mutations in CD79B. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting PIM1 and/or ETV6, which can be coding or non-coding.


Childhood Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

A mature T- and NK-cell non-Hodgkin lymphoma that occurs during childhood.


primary cutaneous diffuse large B-cell lymphoma, Leg type

An aggressive primary cutaneous B-cell lymphoma, usually involving the lower leg. It is composed of a generally monotonous proliferation of immunoblasts, or less frequently centroblasts, with few admixed reactive cells. This type of lymphoma occurs most often in elderly women who present with rapidly growing tumors, usually on one or both legs. Dissemination to extracutaneous sites is frequent. Treatment with combination chemotherapy is usually required.


Stage IV Childhood Anaplastic Large Cell Lymphoma

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Chronic Adult T-Cell Leukemia/Lymphoma

An adult T-cell leukemia/ lymphoma associated with skin lesions and mild lymphadenopathy.  Neoplastic lymphocytes are not numerous in the peripheral blood.  Hypercalcemia is absent.


Splenic marginal zone lymphoma recurrent

The reemergence of splenic marginal zone lymphoma after a period of remission.


Mycosis fungoides stage III

Stage III includes: (T4, N0-2, M0, B0-1); IIIA (T4, N0-2, M0, B0); IIIB (T4, N0-2, M0, B1). T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Central Nervous System Intravascular Large B-Cell Lymphoma

A rare extranodal B-cell non-Hodgkin lymphoma that affects the central nervous system.  It is characterized by the presence of lymphoma cells exclusively in the lumina of small vessels, particularly capillaries.


Ann Arbor Stage II Non-Contiguous Adult Lymphoblastic Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


mantle cell lymphoma

Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''.


Early Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

Primary cutaneous T-cell non-Hodgkin lymphoma that has spread from its original site of growth to nearby tissues.


Lymphoplasmacytoid lymphoma/immunocytoma stage I

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Stage II Childhood Lymphoblastic Lymphoma

Stage II: Disease extent is limited to a single tumor with regional node involvement, 2 or more tumors or nodal areas involved on one side of the diaphragm, or a primary gastrointestinal tract tumor (completely resected) with or without regional node involvement (from PDQ).


Stage III Adult Immunoblastic Lymphoma

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


central nervous system non-hodgkin lymphoma

A non-Hodgkin lymphoma that arises from the central nervous system.


Recurrent Indolent Adult Non-Hodgkin Lymphoma

The reemergence of indolent non-Hodgkin lymphoma in adults after a period of remission.


adult nasal type extranodal NK/T-cell lymphoma

Nasal type extranodal NK/T-cell lymphoma that occurs in adulthood.


Splenic B Lymphoblastic Lymphoma

B-lymphoblastic lymphoma that involves the spleen.


Nodal peripheral T-cell lymphoma with T follicular helper phenotype

Follicular helper T-cell lymphoma that does not meet the criteria for any other specifically defined entity of follicular helper T-cell lymphoma.


T-cell lymphoma refractory

T-cell non-Hodgkin lymphoma that is resistant to treatment.


Advanced Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

Primary cutaneous T-cell non-Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Transformed Lymphoplasmacytic Lymphoma to Diffuse Large B-Cell Lymphoma

Histologic transformation of a lymphoplasmacytic lymphoma to an aggressive diffuse large B-cell lymphoma.


B-cell lymphoma refractory

B-cell non-Hodgkin lymphoma that is resistant to treatment.


Splenic Lymphoblastic Lymphoma

Lymphoblastic lymphoma that affects the spleen.


Ann Arbor Stage I Childhood Non-Hodgkin Lymphoma


Ann Arbor Stage II Contiguous Mantle Cell Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Recurrent Grade 3b Follicular Lymphoma

The reemergence of grade 3b follicular lymphoma after a period of remission.


Stage II Non-Contiguous Adult Indolent Non-Hodgkin Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2 Stage, Tier 1

A term that refers to the staging of childhood non-Hodgkin lymphoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Extranodal marginal zone B-cell lymphoma (MALT type) stage IV

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage IV disease.


AIDS-Related Lymphoblastic Lymphoma

A lymphoblastic lymphoma occurring in HIV-positive patients.


Centroblastic lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


granulomatous slack skin disease

Granulomatous slack skin (GSS) is a variant of mycosis fungoides (MF), a form of cutaneous T-cell lymphoma, and is characterized by the presence of circumscribed areas of pendulous lax skin.


EBV-Related Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma that is caused by Epstein-Barr virus infection.


Stage I Anaplastic Large Cell Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


splenic diffuse red pulp small B-cell lymphoma

Splenic diffuse red pulp small B-cell lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal proliferation of small, monomorphous, basophilic B-lymphocytes, with villous cytoplasm, in the splenic red pulp, bone marrow and peripheral blood. It typically presents in the late clinical stages with splenomegaly and moderate lymphocytosis. Cytopenias are rare and likely associated with hypersplenism.


Centroblastic lymphoma refractory

Centroblastic lymphoma, resistant to treatment.


Stage III Mycosis Fungoides and Sezary Syndrome AJCC v7

Stage III includes: (T4, N0-2, M0, B0-1); IIIA (T4, N0-2, M0, B0); IIIB (T4, N0-2, M0, B1). T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Recurrent Immunoblastic Lymphoma

The reemergence of immunoblastic lymphoma after a period of remission.


Stage IIIB Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IIIB includes: T4, N0-2, M0, B1. T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


EBV-Negative Burkitt Lymphoma

Burkitt lymphoma that is not associated with Epstein-Barr virus infection.


Leukemic Nonnodal Mantle Cell Lymphoma

Mantle cell lymphoma involving the peripheral blood, bone marrow, and often spleen. It usually has an indolent clinical course.


Aggressive Adult Non-Hodgkin Lymphoma

An aggressive non-Hodgkin lymphoma occurring in adults.  Representative examples include Burkitt lymphoma, precursor B-lymphoblastic lymphoma, precursor T-lymphoblastic lymphoma, and adult T-cell lymphoma/leukemia.


Recurrent Adult Burkitt Lymphoma

The reemergence of adult Burkitt lymphoma after a period of remission.


Advanced Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma that has spread extensively to distant anatomic sites or is no longer responding to treatment.


Refractory Indolent T-Cell Non-Hodgkin Lymphoma

Indolent T-cell non-Hodgkin lymphoma that is resistant to treatment.


Refractory Indolent Non-Hodgkin Lymphoma

Indolent non-Hodgkin lymphoma that is resistant to treatment.


Mycosis Fungoides and Sezary Syndrome by AJCC v8 Stage

A term that refers to the staging of mycosis fungoides and Sezary syndrome, following the rules of the TNM AJCC v8 classification system. This prognostic stage groups system is based on the ISCL/EORTC revision to the staging of mycosis fungoides and Sezary syndrome. There is no prognostic stage groups system for primary cutaneous B-cell/T-cell (non-mycosis fungoides/Sezary syndrome) lymphomas at this time. This staging system does not apply to eyelid skin lymphomas (are staged according to the classification for ocular adnexal lymphoma).  (from AJCC 8th Ed.)


Refractory Transformed B-Cell Non-Hodgkin Lymphoma

An indolent B-cell non-Hodgkin lymphoma which has undergone histologic transformation to an aggressive B-cell non-Hodgkin lymphoma and has become resistant to treatment.


Bladder Mucosa-Associated Lymphoid Tissue Lymphoma

A rare mucosa-associated lymphoid tissue lymphoma affecting the bladder.


Primary mediastinal large B-cell lymphoma refractory

Primary mediastinal large B-cell lymphoma that is resistant to treatment.


Burkitt lymphoma in a patient with immunodeficiency.


Recurrent Grade 2 Follicular Lymphoma

The reemergence of grade 2 follicular lymphoma after a period of remission.


B-cell lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Stage IA Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IA includes: T1, N0, M0, B0,1. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Diffuse Large B-Cell Lymphoma, Not Otherwise Specified by Gene Expression Profile

A header term that includes the following diffuse large B-cell lymphoma subtypes by gene expression profiling: activated B-cell-like diffuse large B-cell lymphoma, germinal center B-cell-like diffuse large B-cell lymphoma, and type 3 diffuse large B-cell lymphoma.


Recurrent Childhood Grade III Lymphomatoid Granulomatosis

The reemergence of grade III lymphomatoid granulomatosis in childhood after a period of remission.


primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma

Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma is a rare form of primary cutaneous T-cell lymphoma characterized by rapidly progressing, localized or disseminated nodules, tumors or eczematous skin lesions. It has a particularly aggressive clinical course with a high tendency to spread, in advanced stages, to extracutaneous locations (the central nervous system, lung, testes). Lymph nodes are often spared.


Refractory Intravascular Large B-Cell Lymphoma

Intravascular large B-cell lymphoma that is resistant to treatment.


Ann Arbor Stage IV Grade 1 Follicular Lymphoma


Pleural Primary Effusion Lymphoma

Primary effusion lymphoma that affects the pleural cavity. The majority of patients are HIV-positive men.


Favorable Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma with favorable prognosis.


ocular adnexal lymphoma

A non-Hodgkin lymphoma arising from the conjunctiva, lacrimal gland, lacrimal drainage apparatus, eyelids, or other orbital tissues around the eye. The vast majority of cases are extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue, however, other histologic types of lymphomas can originate from ocular adnexal tissues, including rare cases of NK/T-cell lymphomas of nasal type.


Advanced Stage Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

Involvement of CNS and/or bone marrow. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Ann Arbor Stage II Non-Contiguous Adult Burkitt Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Salivary Gland Mucosa-Associated Lymphoid Tissue Lymphoma

A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue arising from a salivary gland. It usually occurs in the parotid gland and is often associated with Sjogren syndrome. The prognosis is favorable.


high grade B-cell lymphoma

A term that refers to high grade B-cell lymphoma, not otherwise specified or high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.


Ann Arbor Stage I Grade 3 Follicular Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Recurrent Subcutaneous Panniculitis-Like T-Cell Lymphoma

The reemergence of subcutaneous panniculitis-like T-cell lymphoma after a period of remission.


Ann Arbor Stage II Nodular Lymphocyte Predominant Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Pediatric nodal marginal zone lymphoma

A nodal marginal zone lymphoma affecting the pediatric population, predominantly males.  It presents with asymptomatic and localized (mainly head and neck) disease in the vast majority of cases.  Morphologically there is often progressive transformation of the germinal centers.  The prognosis is excellent.


retina lymphoma

A lymphoma that involves the retina.


Refractory NK-Cell Lymphoma, Unclassifiable

NK-cell lymphoma, unclassifiable that is resistant to treatment.


Refractory Follicular T-Cell Lymphoma

Follicular helper T-cell lymphoma, follicular-type that is resistant to treatment.


Pancreatic Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the pancreas with the bulk of the tumor localized to this organ.  The vast majority of cases are of B-cell phenotype and include mucosa-associated lymphoid tissue lymphomas, follicular lymphomas, and diffuse large B-cell lymphomas.


Precursor B-lymphoblastic lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Body Cavity Primary Effusion Lymphoma

A large B-cell lymphoma presenting as a serous effusion without detectable tumor masses. It is universally associated with human herpes virus 8 (HHV8), also called Kaposi sarcoma-associated herpesvirus.  It mostly occurs in the setting of immunodeficiency. The most common sites of involvement are the pleural, pericardial, and peritoneal cavities. (WHO 2017)


B-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical Hodgkin lymphoma

A group of lymphomas displaying molecular, morphologic, immunophenotypic, and clinical overlap between classical Hodgkin lymphoma and diffuse large B-cell lymphoma. This term particularly applies to mediastinal lymphomas with overlapping features of mediastinal (thymic) large B-cell lymphoma and classical Hodgkin lymphoma.


Stage II Adult Immunoblastic Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


Stage IA Mycosis Fungoides AJCC v7

Stage IA includes: T1, N0, M0, B0-1.  T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Small Intestinal T-Cell Non-Hodgkin Lymphoma

A T-cell non-Hodgkin lymphoma that arises from the small intestine.  It includes the enteropathy-associated T-cell lymphoma and the monomorphic CD56 positive intestinal T-cell lymphoma.


Stage II Contiguous Adult Indolent Non-Hodgkin Lymphoma


Angiocentric lymphoma refractory

Nasal type extranodal NK/T-cell lymphoma that does not respond to treatment.


AIDS-Related Plasmablastic Lymphoma

A plasmablastic lymphoma in a patient with acquired immunodeficiency syndrome.


High Grade B-Cell Lymphoma, Not Otherwise Specified

High-grade B-cell lymphoma with blastoid features or features between diffuse large B-cell lymphoma and Burkitt lymphoma that lacks MYC, BCL2, and BCL6 gene rearrangements.


Pediatric follicular lymphoma

A nodal follicular lymphoma with favorable prognosis. It lacks BCL-2 rearrangement and 14;18 translocation. Nearly all cases are localized. It is usually seen in the pediatric population but similar lymphomas may occur in adults.


Sinonasal Extranodal NK/T-Cell Lymphoma

An extranodal NK/T-cell lymphoma that arises from the sinonasal tract.


large B-cell diffuse lymphoma of kidney

Diffuse large B-cell lymphoma that affects the kidney.


Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder

A diffuse large B-cell lymphoma that arises in a patient with a history of organ transplantation.


Lymphoma, Mixed-Cell, Follicular

A follicular lymphoma which contains 6-15 centroblasts per 40X high-power microscopic field.


EZB diffuse large B-cell lymphoma

A diffuse large B-cell lymphoma that is categorized as EZB with high probability by the LymphGen algorithm. This is based on a combination of genetic features and EZB DLBCLs often, but do not always, have hot spot mutations in EZH2 and/or a BCL2 translocation. This class can be further subdivided into two sub-classes EZB-MYC+ and EZB-MYC- using the double hit gene expression signature (DHITsig). This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting IRF8, which can be coding or non-coding.


B-cell lymphoma stage III

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Recurrent Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma

The reemergence of primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma after a period of remission.


Anaplastic Large Cell Lymphoma, Giant Cell Rich Subtype

An anaplastic large cell lymphoma characterized by the presence of numerous giant cells.


Cutaneous Mantle Cell Lymphoma

Mantle cell lymphoma that affects the skin.


Ann Arbor Stage II Grade 2 Follicular Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

The reemergence of diffuse large B-cell lymphoma, not otherwise specified after a period of remission.


Recurrent T Lymphoblastic Lymphoma

The reemergence of T-lymphoblastic lymphoma after a period of remission.


Centroblastic Lymphoma Post-Transplant Lymphoproliferative Disorder

A centroblastic lymphoma that arises in a patient with a history of organ transplantation.


HHV-8 and EBV-Negative Primary Effusion-Based Lymphoma

An HHV-8 and EBV-negative primary effusion-based lymphoma that affects elderly, HIV-negative patients with history of medical conditions that result in fluid overload. The majority of cases have been reported in Japan. Most tumors exhibit centroblastic or immunoblastic morphology. The prognosis is good.


Refractory Transformed Mycosis Fungoides

Transformed mycosis fungoides that is resistant to treatment.


B-cell small lymphocytic lymphoma stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Lacrimal System Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the lacrimal gland or the lacrimal drainage system. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma.


Childhood Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma occurring in childhood.


Stage I Non-Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Small Lymphocytic Lymphoma with Plasmacytoid Differentiation

A small lymphocytic lymphoma characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology.


Intestinal T-Cell Lymphoma

A group of mature T-cell and NK-cell non-Hodgkin lymphomas that includes enteropathy-associated T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma, and intestinal T-cell lymphoma, not otherwise specified. Most of these lymphomas arise from the small intestine and a minority from the large intestine or stomach.


Duodenal-type follicular lymphoma

A localized low-grade follicular lymphoma within the gastrointestinal tract, which is distinct from other gastrointestinal tract follicular lymphomas.  It has features that overlap with in situ follicular neoplasia as well as some features resembling an extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. The prognosis is excellent.


Lymphoplasmacytoid lymphoma/immunocytoma stage IV


Oropharyngeal Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the oropharynx.


Stage I Indolent Adult Non-Hodgkin Lymphoma


Mantle cell lymphoma recurrent

The reemergence of a mantle cell lymphoma after a period of remission.


Lugano Classification Stage II Bulky Adult Non-Hodgkin Lymphoma AJCC v8

Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Lymphomatous Adult T-Cell Leukemia/Lymphoma

An adult T-cell leukemia/lymphoma characterized by generalized lymphadenopathy without peripheral blood involvement.  Most patients have advanced disease, however hypercalcemia is not frequently present.


Pleomorphic Variant Mantle Cell Lymphoma

An aggressive mantle cell lymphoma characterized by the presence of pleomorphic neoplastic B-lymphocytes.


Burkitt's lymphoma of spleen

Burkitt lymphoma that involves the spleen.


Stage IV Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

Initial CNS and/or bone marrow involvement. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Major Salivary Gland Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the parotid gland, submandibular gland, or sublingual gland.  Representative examples include mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


Ann Arbor Stage II Grade 3 Non-Contiguous Follicular Lymphoma

Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Lymphoplasmacytoid lymphoma/immunocytoma stage II

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Recurrent NK-Cell Lymphoma, Unclassifiable

The reemergence of NK-cell lymphoma, unclassifiable after a period of remission.


Diffuse large B-cell lymphoma, unclassifiable, NOS

A biologic subset of diffuse large B-cell lymphomas (DLBCL) that do not overexpress the genes whose overexpression characterizes the germinal center B-cell-like and activated B-cell-like DLBCL.  Morphologically, these lymphomas are either immunoblastic or centroblastic.  Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome, similar to those with an activated B-cell-like gene expression profile.


Recurrent Follicular T-Cell Lymphoma

The reemergence of follicular helper T-cell lymphoma, follicular-type after a period of remission.


Stage IVA2 Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage IVA2 includes: T1-4, N3, M0, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


mycosis fungoides variant

A header term that includes the rare following variants of mycosis fungoides: folliculotropic mycosis fungoides, granulomatous slack skin disease, and pagetoid reticulosis.


Primary Bone Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement.  The femur, spine, and pelvic bones are the most frequently affected areas.  The majority of cases are diffuse large B-cell lymphomas.  Most patients present with pain in the affected area.  Systemic symptoms are rare.


Recurrent Primary Vitreoretinal Non-Hodgkin Lymphoma

The reemergence of primary vitreoretinal non-Hodgkin lymphoma after a period of remission.


Stage I Mycosis Fungoides and Sezary Syndrome AJCC v8

Stage I includes: IA (T1, N0, M0, B0,1); IB (T2, N0, M0, B0,1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Methotrexate-Associated Peripheral T-Cell Lymphoma

A peripheral T-cell lymphoma that develops in patients who are immunosuppressed with methotrexate.


Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Diffuse large B-cell lymphoma, not otherwise specified that is resistant to treatment.


Refractory Lymphoblastic Lymphoma

Lymphoblastic lymphoma that is resistant to treatment.


Ann Arbor Stage II Grade 2 Non-Contiguous Follicular Lymphoma