Primary Insomnia

A sleep disorder characterized by difficulty initiating or maintaining sleep; this difficulty does not occur in the context of another sleep disorder and is not etiologically linked to a mental disorder, substance use, or a general medical condition.


GAC codon-amino acid adaptor activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A triplet codon-amino acid adaptor activity that recognizes a GAC codon.


tetrol

A polyol that contains 4 hydroxy groups.


A hydroxycalciol that is a synthetic fluorinated and deuterated analogue of vitamin D3 which exhibits vitamin D receptor superagonist and anti-cancer activity.


1alpha,23(S),25-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) bearing additional hydroxy substituents at positions 1, 23 and 25 (with 1alpha,23S-configuration). An intermediate in the degradation pathway of 1alpha,25-(OH)2D3.


(20S,23,24)-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration), 23 and 24.


A vitamin D that is 19-norcalcitriol carrying an additional 3-hydroxypropyl substituent at position 2. A synthetic analogue of vitamin D, it exhibits anticancer properties.


Nordihydroguaiaretic acid

A tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups. Masoprocol, the meso-form found in the leaves of the creosote bush (Larrea divaricata), is a potent lipoxygenase inhibitor.


Eldecalcitol

A hydroxycalciol that is calcitriol with a 3-hydroxypropoxy group at position 2.


(20S,23,25)-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration), 23 and 25.


A hydroxycalciol that is calcitriol with a 4-hydroxybutoxy group at position 2.


diphosphate-purine nucleoside kinase activity

Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide.


germarium-derived female germ-line cyst formation

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster.


Cor triloculare

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A congenital anatomic anomaly in which the heart has only three chambers.


Splenic Manifestation of Chronic Lymphocytic Leukemia

Infiltration of the spleen by chronic lymphocytic leukemia. It primarily involves the white pulp.


aspartate kinase activity

Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+.


amino acid kinase activity

Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate.


glutamate 5-kinase activity

Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+.


homoserine kinase activity

Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+.


hydroxylysine kinase activity

Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H+.


Catalysis of the reaction: ATP + N-acetyl-L-2-aminoadipate = ADP + N-acetyl-L-2-aminoadipate 6-phosphate.


arginine kinase activity

Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H+.


GMP catabolic process to IMP

The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate.


Kaposi's sarcoma of oral cavity

Kaposi sarcoma arising from the oral cavity.


extraglomerular mesangial cell proliferation

The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa.


mesonephric extraglomerular mesangial cell proliferation involved in mesonephros development

The multiplication or reproduction of extraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa.


thoracic vertebra 12

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The twelfth thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].


Parotid Gland Lipoma

A lipoma that arises from the parotid gland.


negative regulation of granulosa cell proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell proliferation.


adenylate cyclase-inhibiting adrenergic receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor, and ending with the regulation of a downstream cellular process.


insect internal sensillum

Sensillum that is internal to the animal - i.e. having no part that is part of the cuticle.


insect Bolwig organ

Visual organ of the larva. It consists of a dense cluster of 12 ciliated photoreceptor neurons.


chanoclavine-I aldehyde biosynthetic process

The chemical reactions and pathways resulting in the formation of chanoclavine-I aldehyde. Chanoclavine-I aldehyde is at a branching point in the biosynthetic pathways of fumigaclavine C and ergotamine.


negative regulation of positive chemotaxis to cAMP by DIF-2

Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone.


positive regulation of epidermal growth factor receptor signaling pathway involved in heart process

Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process.


positive regulation of ERBB3 signaling pathway

Any process that activates or increases the frequency, rate or extent of ERBB3 signaling pathway.


evasion of host immune response via modulation of host complement system

Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction.


glutamate dehydrogenase (NADP+) activity

Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.


splenic arteriole

A tiny terminal artery that is continuous with the capillaries in the spleen.


spleen central arteriole

A blood vessel surrounded by the periarteriolar lymphoid sheath that connects the trabecular artery to the trabecular vein.


penicillar arteriole

One of the small straight arteries of the red pulp of the spleen; a branch of the spleen central artery that supplies the red pulp[WP,modified].


Pyrazine

A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.


An  oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.


extrathymic T cell differentiation

The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus.


old cell tip after activation of bipolar cell growth

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.


regulation of dehydroaustinol biosynthetic process

Any process that modulates the frequency, rate or extent of dehydroaustinol biosynthetic process.


negative regulation of dehydroaustinol biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of dehydroaustinol biosynthetic process.


mannose-specific flocculation

The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other.


glucarate biosynthetic process

The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid.


glucarate metabolic process

The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate.


glucarate catabolic process

The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid.


D-glucarate catabolic process

The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate.


D-glucarate metabolic process

The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose.


D-glucarate biosynthetic process

The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate.


(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity

Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.


deoxyribonuclease IV (phage-T4-induced) activity

Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.


cholesterol biosynthetic process via 24,25-dihydrolanosterol

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol.


proline racemase activity

Catalysis of the reaction: L-proline = D-proline.


modulation by symbiont of host protein localization to phagocytic vesicle

Any process in which an organism modulates the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction.


Ann Arbor Stage I Lymphocyte-Depleted Classic Hodgkin Lymphoma

Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Ann Arbor Stage I Supradiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


Ann Arbor Stage I Subdiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


Diaper candidiasis

An inflammatory skin condition in the diaper area superimposed with Candida infection, characterized by a bright red rash with a sharply demarcated edge and satellite lesions. Skin folds are often involved.


cellular hypotonic salinity response

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


hypotonic salinity response

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


mutator focus

A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules.


Stage IB Adult Soft Tissue Sarcoma AJCC v7


Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2.


negative regulation of type IIa hypersensitivity

Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response.


negative regulation of tolerance induction to nonself antigen

Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen.


regulation of type III hypersensitivity

Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response.


negative regulation of tolerance induction dependent upon immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response.


positive regulation of T cell antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation.


positive regulation of complement activation, classical pathway

Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway.


regulation of antibody-dependent cellular cytotoxicity

Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity.


negative regulation of B cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation.


regulation of tolerance induction to nonself antigen

Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen.


positive regulation of B cell antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation.


negative regulation of type IIb hypersensitivity

Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response.


regulation of tolerance induction dependent upon immune response

Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response.


negative regulation of T-helper 17 cell lineage commitment

Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment.


helper T cell enhancement of B cell mediated immune response

Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell.


positive regulation of type IIb hypersensitivity

Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response.


regulation of B cell antigen processing and presentation

Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation.


negative regulation of type II hypersensitivity

Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity.


negative regulation of T cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.


positive regulation of peripheral tolerance induction

Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction.


positive regulation of tolerance induction to nonself antigen

Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen.


helper T cell enhancement of T cell mediated immune response

Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell.


negative regulation of antibody-dependent cellular cytotoxicity

Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity.


regulation of peripheral tolerance induction

Any process that modulates the frequency, rate, or extent of peripheral tolerance induction.


positive regulation of tolerance induction dependent upon immune response

Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response.


negative regulation of type III hypersensitivity

Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response.


negative regulation of type I hypersensitivity

Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response.


regulation of type IIb hypersensitivity

Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response.


positive regulation of type IV hypersensitivity

Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.


positive regulation of type III hypersensitivity

Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response.


negative regulation of peripheral tolerance induction

Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction.


sialic acid:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in).


copper-nicotianamine transmembrane transporter activity

Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other.


regulation of somatic stem cell division

Any process that modulates the frequency, rate or extent of somatic stem cell division.


positive regulation of somatic stem cell division

Any process that activates or increases the frequency, rate or extent of somatic stem cell division.


negative regulation of somatic stem cell division

Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division.


Midgut Neuroendocrine Tumor G1

A well-differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the jejunum, ileum, proximal colon, or appendix. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Meckel Diverticulum Neuroendocrine Tumor G1

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises in a Meckel diverticulum.


riboflavin synthase complex

An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine.


Fused-Smurf ubiquitin ligase complex

A ubiquitin ligase complex. In D. melanogaster, it regulates ubiquitination and proteolysis of the BMP receptor Thickveins in cystoblasts, potentially by controlling Tkv ubiquitination and degradation.


Psoralen and long-wave ultraviolet radiation (PUVA) keratosis

A hyperkeratotic skin lesion that occurs in patients with a history of prolonged exposure to psoralen and ultraviolet A (PUVA) therapy.


Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin.


citrate (Si)-synthase activity

Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.


citrate synthase activity

Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.


citrate (Re)-synthase activity

Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group.


cerebellar plate

The embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium.


L-Mannitol

The L-enantiomer of mannitol.


modulation of relaxation of smooth muscle in another organism

The process in which an organism effects a change in the relaxation of smooth muscle in a second organism.


positive regulation of relaxation of uterine smooth muscle in another organism

The process in which an organism increases the extent of relaxation of smooth muscle in the uterus of a second organism.


modulation of relaxation of uterine smooth muscle in another organism

The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism.


Oral Cavity Mucosal Melanoma

A rare melanoma that arises from the oral cavity. It is associated with a poor prognosis.


translation at presynapse

Translation that occurs at the presynapse.


translation at presynapse, modulating chemical synaptic transmission

Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.


negative regulation of glutathione peroxidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of glutathione peroxidase activity.


negative regulation of thioredoxin peroxidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of thioredoxin peroxidase activity.


negative regulation of tyrosinase activity

Any process that stops or reduces the activity of a tyrosinase enzyme.


negative regulation of pyruvate dehydrogenase activity

Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate dehydrogenase activity.


negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity

Any process that stops, prevents or reduces the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity.


negative regulation of succinate dehydrogenase activity

Any process that stops, prevents or reduces the frequency, rate or extent of succinate dehydrogenase activity.


negative regulation of heme oxygenase activity

Any process that stops, prevents, or reduces the frequency or rate of heme oxygenase activity.


negative regulation of primary amine oxidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of primary amine oxidase activity.


negative regulation of cytokinin dehydrogenase activity

Any process that stops, prevents or reduces the frequency, rate or extent of cytokinin dehydrogenase activity.


negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity

Any process that stops, prevents or reduces the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity.


negative regulation of peroxidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity.


negative regulation of D-amino-acid oxidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of D-amino-acid oxidase activity.


Trapezium-Trapezoid Joint

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The articulation of the trapezium and trapezoid bones in the wrist.


regulation of advanced glycation end-product receptor activity

Any process that modulates the frequency, rate or extent of advanced glycation end-product receptor activity.


negative regulation of advanced glycation end-product receptor activity

Any process that stops, prevents or reduces the frequency, rate or extent of advanced glycation end-product receptor activity.


extracellular matrix of synaptic cleft

The portion of the extracellular matrix that lies within the synaptic cleft.


coronal suture morphogenesis

The process in which the coronal suture is generated and organized.


lambdoid suture morphogenesis

The process in which the lambdoid suture is generated and organized.


sagittal suture morphogenesis

The process in which the sagittal suture is generated and organized.


Tramadol

A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.


positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling

Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud.


Benign Adult Brain Stem Neoplasm

A benign neoplasm of the brain stem occurring in adults.


Medullary Hemangioblastoma

A hemangioblastoma that arises from the medulla oblongata. It may be associated with von Hippel-Lindau disease.


Childhood Brain Stem Gliosarcoma

A gliosarcoma that arises from the brain stem and occurs during childhood.


Recurrent Childhood Brain Stem Astrocytoma

The reemergence of brain stem astrocytoma in childhood after a period of remission.


Childhood Brain Stem Mixed Glioma

A mixed glioma that arises from the brain stem and occurs during childhood.


Metastatic malignant neoplasm to brain stem

A malignant neoplasm that has spread from its original site of growth to the brain stem.


Recurrent Childhood Brain Stem Glioma

The reemergence of brain stem glioma in childhood after a period of remission.


Anaplastic Brain Stem Astrocytoma

An anaplastic astrocytoma that arises from the brain stem.


Brain Stem Glioblastoma

A glioblastoma that arises from the brain stem.


Anaplastic Brain Stem Glioma

An anaplastic glioma that arises from the brain stem.


cellular response to phosphate starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.


(S)-limonene 1,2-monooxygenase NADPH activity

Catalysis of the reaction: (4S)-limonene + NADPH+= + H+ + O2 = NADP+ + H2O + (4S)-limonene-1,2-epoxide.


Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide.


D-nopaline dehydrogenase activity

Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH.


Recurrent Acute Bilineal Leukemia

The reemergence of acute bilineal leukemia after a period of remission.


Recurrent Mixed Phenotype Acute Leukemia

The reemergence of mixed phenotype acute leukemia after a period of remission.


acute biphenotypic leukemia in relapse

The reemergence of acute biphenotypic leukemia after a period of remission.


mesenchymal to epithelial transition involved in renal vesicle formation

A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle.


mesenchymal to epithelial transition involved in metanephric renal vesicle formation

A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle.


mesenchymal to epithelial transition involved in mesonephric renal vesicle formation

A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle.


mesenchymal to epithelial transition involved in mesonephros morphogenesis

A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros.


The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine.


phosphonoacetate metabolic process

The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue.


cspyrone B1 biosynthetic process

The chemical reactions and pathways resulting in the formation of cspyrone B1.


ecdysteroid 22-kinase activity

Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+.


tartrate epimerase activity

Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate.


bBAF complex

A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180.


Ampulla of Vater Neuroendocrine Tumor G3

A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The Ki-67 index is higher than 20%.


Low Risk Small Intestinal Gastrointestinal Stromal Tumor


Low Risk Esophageal Gastrointestinal Stromal Tumor


Low Risk Colorectal Gastrointestinal Stromal Tumor


Low Risk Gastric Gastrointestinal Stromal Tumor


GTP cyclohydrolase II activity

Catalysis of the reaction: GTP + 3 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H+.


2-oxoglutarate synthase activity

Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin.


(+)-2-epi-prezizaene synthase activity

Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid.


2-cis,6-cis-farnesyl pyrophosphate synthase activity

Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> 2 diphosphate + (2Z,6Z)-farnesyl diphosphate.


Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde.


negative regulation of substance P receptor binding

Any process that stops, prevents or reduces the frequency, rate or extent of substance P receptor binding.


Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form thin-branching papillae and exhibit high grade dysplasia.


Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that are similar to gastric foveolar epithelial cells.


Branch Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

An intraductal papillary-mucinous neoplasm of the pancreas that arises in one of the branches of the main pancreatic duct.  It usually has an indolent behavior.


Mixed Type Pancreatic Intraductal Papillary-Mucinous Neoplasm

An intraductal papillary-mucinous neoplasm of the pancreas that arises primarily from the main pancreatic duct and extends to the branch ducts.


Pancreatic Intraductal Papillary Mucinous Neoplasm, Oncocytic-Type

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells with abundant eosinophilic granular cytoplasm.


Main Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

An intraductal papillary-mucinous neoplasm of the pancreas that arises from the main pancreatic duct.


Pancreatic Intraductal Papillary Mucinous Neoplasm, Intestinal-Type

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form tall papillae, similar to those that are present in colonic villous adenomas.


Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA.


toluene oxidation via 4-hydroxytoluene

The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol).


toluene metabolic process

The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications.


toluene oxidation to catechol

The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2).


toluene oxidation

The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene.


anaerobic toluene metabolic process

The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen.


toluene oxidation via 2-hydroxytoluene

The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol).


toluene oxidation via 3-hydroxytoluene

The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol).


toluene oxidation via toluene-cis-1,2-dihydrodiol

The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol.


toluene catabolic process

The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.


anaerobic toluene catabolic process

The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen.


negative regulation of amacrine cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation.


regulation of amacrine cell differentiation

Any process that modulates the frequency, rate or extent of amacrine cell differentiation.


positive regulation of amacrine cell differentiation

Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation.


Advanced Rhabdoid Tumor

Rhabdoid tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Rhabdoid Tumor

A rhabdoid tumor that has spread from the original site of growth to another anatomic site.


Inferior Anastomotic Vein of the Labbe

A superficial blood vessel within the brain that drains the temporal lobe.


sialadenoma papilliferum of salivary gland

An uncommon exophytic papillary proliferation that involves mucosal surface epithelium and salivary duct epithelium. It is exceptional among salivary gland neoplasms because it manifests as an exophytic papillary excrescence of the mucosa, rather than as a submucosal or intraglandular mass. It most often affects the hard or soft palate.  It is generally asymptomatic.


Aurachin C

A C-type aurachin that is quinolin-4-one which is substituted by a hydroxy group at positions 1, a methyl group at position 2, and a triprenyl group at position 3.


Elevated Sedimentation Rate

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A higher than average sedimentation rate in a sample.


Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP+ = 2,4-dichlorobenzoyl-CoA + NADPH.


Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite.


alphaIIb-beta3 integrin-ICAM-4 complex

A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4.


lateral sprouting involved in mammary gland duct morphogenesis

The process in which a branch forms along the side of a mammary duct.


deep circumflex iliac artery

The deep circumflex iliac artery (or deep iliac circumflex artery) is an artery in the pelvis that travels along the iliac crest of the pelvic bone.


negative regulation of androgen secretion

Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion.


negative regulation of defecation

Any process that stops, prevents or reduces the frequency, rate or extent of defecation.


negative regulation of defecation rhythm

Any process that stops, prevents or reduces the frequency, rate or extent of defecation rhythm.


negative regulation of thyroid-stimulating hormone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion.


negative regulation of ecdysteroid secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid.


negative regulation of substance P secretion

Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion.


negative regulation of corticosterone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion.


negative regulation of histamine secretion by mast cell

Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell.


negative regulation of androstenedione secretion

Any process that stops, prevents or reduces the frequency, rate or extent of androstenedione secretion.


negative regulation of renal sodium excretion by angiotensin

The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time.


negative regulation of testosterone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion.


negative regulation of glutamate secretion, neurotransmission

Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission.


negative regulation of dehydroepiandrosterone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of dehydroepiandrosterone secretion.


negative regulation of estradiol secretion

Any process that stops, prevents or reduces the frequency, rate or extent of estradiol secretion.


negative regulation of bile acid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.


negative regulation of saliva secretion

Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion.


negative regulation of progesterone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion.


negative regulation of activin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell.


negative regulation of growth hormone secretion

Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.


negative regulation of glycine secretion, neurotransmission

Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission.


negative regulation of substance P secretion, neurotransmission

Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion, neurotransmission.


negative regulation of estrogen secretion

Any process that stops, prevents or reduces the frequency, rate or extent of estrogen secretion.


negative regulation of somatostatin secretion

Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


negative regulation of aldosterone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion.


negative regulation of aspartate secretion

Any process that stops, prevents or reduces the frequency, rate or extent of aspartate secretion.


negative regulation of corticotropin-releasing hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell.


negative regulation of calcitonin secretion

Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion.


negative regulation of parathyroid hormone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion.


negative regulation of mineralocorticoid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion.


negative regulation of inhibin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell.


negative regulation of corticotropin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell.


negative regulation of estrone secretion

Any process that stops, prevents or reduces the frequency, rate or extent of estrone secretion.


negative regulation of cortisol secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell.


negative regulation of arachidonic acid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion.


negative regulation of juvenile hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone.


Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H+.


Catalysis of the reaction: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H+ + phosphate.


negative regulation of midbrain dopaminergic neuron differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of midbrain dopaminergic neuron differentiation.


Low Grade Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is low grade.


unsaturated chondroitin disaccharide hydrolase activity

Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate.


Tentorial Tear Related to Birth

Disruption of the tentorium cerebelli incurred during delivery.


catagen

The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced.


anagen

The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair.


exogen

The shedding phase of the hair cycle.


telogen

The resting phase of hair cycle.


1-undecene metabolic process

The chemical reactions and pathways involving 1-undecene.


sphingoid catabolic process

The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.


3-keto-sphinganine metabolic process

The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine.


sphingosine catabolic process

The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.


phytosphingosine metabolic process

The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids.


phytosphingosine biosynthetic process

The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol.


shikimate metabolic process

The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids.


shikimate catabolic process

The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid.


heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide

The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan.


response to meiotic cell cycle checkpoint signaling

A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint.


response to meiotic spindle assembly checkpoint signaling

A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling.


response to meiotic DNA replication checkpoint signaling

A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling.


anaerobic phenylalanine oxidation

The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde.


liver primordium

A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum.


Tubo-ovarian abscess

An abscess involving the distal fallopian tube and ovary. It is caused by pelvic inflammatory disease or other infections.


deep cervical artery

The deep cervical artery (Profunda cervicalis) is an artery of the neck.


Stage II Childhood Hodgkin Lymphoma

Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


collagen type X trimer

A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets).


Carsickness

A sensation of discomfort associated with ground travel; symptoms may include nausea, vomiting, dizziness or sweating.


The chemical reactions and pathways resulting in the formation of hercynylselenocysteine.


superior parathyroid gland

Either of two paired parathyroid glands closest to the head.


Refractory Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that does not respond to treatment.


Refractory Head and Neck Squamous Cell Carcinoma

A head and neck squamous cell carcinoma that does not respond to treatment.


Refractory Sinonasal Squamous Cell Carcinoma

Nasal cavity and paranasal sinus squamous cell carcinoma that does not respond to treatment.


Refractory Oral Cavity Squamous Cell Carcinoma

Oral cavity squamous cell carcinoma that does not respond to treatment.


Refractory Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that does not respond to treatment.


Hodgkin's lymphoma of small intestine

A Hodgkin lymphoma that arises from the small intestine.


transcription factor TFIIIE complex

A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins.


Resectable Pancreatic Acinar Cell Carcinoma

Pancreatic acinar cell carcinoma that is amenable to surgical resection.


Pancreas carcinoma resectable

Carcinoma of the pancreas amenable to surgical removal.


Borderline Resectable Pancreatic Adenocarcinoma

A pancreatic adenocarcinoma term that refers to a continuum between resectable and locally advanced unresectable disease.


Pancreatic adenocarcinoma resectable

Pancreatic adenocarcinoma that is amenable to surgical resection.


Resectable Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma amenable to surgical resection.


Resectable Pancreatic Adenosquamous Carcinoma

Pancreatic adenosquamous carcinoma that is amenable to surgical resection.


4-alpha-methyl-delta7-sterol oxidation

A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O.


negative regulation of protein-glutamine gamma-glutamyltransferase activity

Any process that stops, prevents or reduces the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity.


lachrymatory factor synthase activity

Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide.


negative regulation of gamma-delta T cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation.


negative regulation of CD8-positive, alpha-beta T cell proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.


negative regulation of T cell homeostatic proliferation

Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.


negative regulation of NK T cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation.


Stage I Lip and Oral Cavity Cancer AJCC v8

Stage I includes: T1, N0, M0.  T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less depth of invasion (DOI).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


positive regulation of centriole-centriole cohesion

Any process that activates or increases the frequency, rate or extent of centriole-centriole cohesion.


negative regulation of centriole-centriole cohesion

Any process that stops, prevents or reduces the frequency, rate or extent of centriole-centriole cohesion.


negative regulation of age-related resistance

Any process that stops, prevents or reduces the extent of age-related resistance.


cutaneous vein

One of a number of veins in the subcutaneous tissue that empty into deep veins.


Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine.


propanediol catabolic process

The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH.


propanediol metabolic process

The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items.


anaerobic glycerol catabolic process to propane-1,3-diol

The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water.


negative regulation of epithelial cell-cell adhesion involved in epithelium migration

Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration.


regulation of epithelial cell-cell adhesion involved in epithelium migration

Any process that modulates the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration.


positive regulation of epithelial cell-cell adhesion involved in epithelium migration

Any process that activates or increases the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration.


Hemolytic anemia due to disseminated intravascular coagulation


Anemia due to membrane defect

A group of inherited hemolytic anemias caused by erythrocyte membrane defects. This includes hereditary pyropoikilocytosis, hereditary spherocytosis and hereditary elliptocytosis.


Immune Hemolytic Anemia

An acquired anemia resulting from immune-mediated destruction of the red blood cells. Causes include autoimmune disorders, blood transfusions, and drugs.


Anemia, Hemolytic, Acquired

Hemolytic anemia, the cause of which is not present at birth.


Infantile pyknocytosis

A rare, neonatal syndrome characterized by early jaundice that becomes rapidly associated with severe hemolytic anemia. The peripheral blood smear is remarkable for small irregular, contracted red blood cells with hyper-dense spikes (pyknocytes), that progressively increase in number and then spontaneously disappear.


Angiocentric immunoproliferative lesion grade 2

Lymphomatoid granulomatosis characterized by the presence of occasional large lymphoid cells or immunoblasts in a polymorphous background. Necrosis is more commonly seen as compared to grade I lymphomatoid granulomatosis. By in situ hybridization, EBV-positive cells are readily seen.


Central Nervous System Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis that affects the brain, spinal cord, and leptomeninges.


Cutaneous Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis that affects the skin.


Childhood Lymphomatoid Granulomatosis

Lymphomatoid granulomatosis that occurs during childhood.


telomere single strand break repair

Single strand break repair that takes place in a telomere.


nucleosomal methylation activator complex

A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription.


High Grade Anal Canal Intraepithelial Neoplasia

Intraepithelial neoplasia involving the anal canal.  The epithelial cells exhibit moderate dysplasia (grade II intraepithelial neoplasia) or severe dysplasia (grade III intraepithelial neoplasia or carcinoma in situ).


negative regulation of meiotic chromosome separation

Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation.


HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 6

A lipid transport disorder characterized by extremely elevated levels of high density lipoprotein cholesterol (HDL C; HDLC). It is caused by heterozygous mutations in the SCARB1 gene that result in decreased transport of HCL C into the liver by scavenger receptor class B member 1.


posterior cibarial plate morphogenesis

The process in which the anatomical structures of the posterior cibarial plate are generated and organized.


carbonate ester

Any carbonate that is carbonic acid in which the hydrogens have been replaced by organyl groups.


sarcinapterin biosynthetic process

The chemical reactions and pathways resulting in the formation of sarcinapterin.


sarcinapterin metabolic process

The chemical reactions and pathways involving sarcinapterin.


NADPH-cytochrome-c2 reductase activity

Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2.


(s)-Salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has S configuration.


(r)-Salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has R configuration.


alkanesulfonate monooxygenase activity

Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN.


Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O.


4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin].


2-hydroxyisoflavanone synthase activity

Catalysis of the reactions: liquiritigenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase] and (2S)-naringenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase].


licodione synthase activity

Catalysis of the reaction: H+ + liquiritigenin + NADPH + O2 = H2O + licodione + NADP+.


aflatoxin B synthase activity

Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O2 <=> aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2).


alkanal monooxygenase (FMN-linked) activity

Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light.


uvaol dehydrogenase activity

Catalysis of the reaction: uvaol + NADPH + O2 + H+ <=> ursolic aldehyde + NADP + 2 H2O.


7-deoxyloganin 7-hydroxylase activity

Catalysis of the reaction: 7-deoxyloganin + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganin + oxidized [NADPH-hemoprotein reductase].


Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O.


sterol 12-alpha-hydroxylase activity

Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.


nitrilotriacetate monooxygenase activity (FMN-dependent)

Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN.


3-chloro THPH synthase activity

Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O.


2,5-diketocamphane 1,2-monooxygenase

Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O.


pipecolic acid N-hydroxylase

Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O.


Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H+ + NADPH + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP+.


3,5 dichloro-THPH synthase activity

Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O.


very long-chain fatty acid omega-hydroxylase activity

Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. A very long chain fatty acid is a fatty acid with an aliphatic tail of 22 or more carbons.


Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+.


Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O2 = 3,4-dihydroxyphenylacetate + FAD + H+ + H2O.


germacrene A hydroxylase activity

Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase].


Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase].


long-chain fatty acid omega-hydroxylase activity

Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


medium-chain fatty acid omega-hydroxylase activity

Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.


fatty acid omega-hydroxylase activity

Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


7-deoxyloganate 7-hydroxylase activity

Catalysis of the reaction:  7-deoxyloganate + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O +  loganate + oxidized [NADPH-hemoprotein reductase].


isoflavone 2'-hydroxylase activity

Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase].


Golgi cell precursor proliferation

The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


sarcosine metabolic process

The chemical reactions and pathways involving sarcosine.


sarcosine catabolic process

The chemical reactions and pathways resulting in the breakdown of sarcosine.


sarcosine biosynthetic process

The chemical reactions and pathways resulting in the formation of sarcosine.


3-cyano-L-alanine catabolic process

The chemical reactions and pathways resulting in the breakdown of 3-cyano-L-alanine.


Refractory Neuroblastoma

A neuroblastoma that does not respond to treatment.


Reactive Hyperplasia of the Retinal Pigment Epithelium

A reactive, non-neoplastic hyperplasia of the retinal pigment epithelium.


AGA codon-amino acid adaptor activity

A triplet codon-amino acid adaptor activity that recognizes an AGA codon.


negative regulation of cell proliferation involved in heart valve morphogenesis

Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.


regulation of cell proliferation involved in heart valve morphogenesis

Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.


positive regulation of cell proliferation involved in heart valve morphogenesis

Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.


regulation of mRNA cap binding

Any process that modulates the frequency, rate or extent of mRNA cap binding.


negative regulation of transferrin receptor binding

Any process that stops, prevents or reduces the frequency, rate or extent of transferrin receptor binding.


negative regulation of selenocysteine insertion sequence binding

Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding.


negative regulation of apolipoprotein binding

Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding.


regulation of small GTPase binding

Any process that modulates the frequency, rate or extent of small GTPase binding.


regulation of actin binding

Any process that modulates the frequency, rate or extent of actin binding.


regulation of heparan sulfate proteoglycan binding

Any process that modulates the frequency, rate or extent of heparan sulfate proteoglycan binding.


negative regulation of lipid binding

Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding.


regulation of C-C chemokine binding

Any process that modulates the frequency, rate or extent of C-C chemokine binding.


regulation of polysome binding

Any process that modulates the frequency, rate or extent of polysome binding.


regulation of core promoter binding

Any process that modulates the frequency, rate or extent of core promoter binding.


negative regulation of C-C chemokine binding

Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine binding.


negative regulation of actin binding

Any process that stops, prevents or reduces the frequency, rate or extent of actin binding.


regulation of selenocysteine insertion sequence binding

Any process that modulates the frequency, rate or extent of selenocysteine insertion sequence binding.


negative regulation of chemokine activity

Any process that stops, prevents or reduces the frequency, rate or extent of chemokine activity.


negative regulation of double-stranded telomeric DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of double-stranded telomeric DNA binding.


negative regulation of microtubule binding

Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding.


negative regulation of growth hormone activity

Any process that stops, prevents or reduces the frequency, rate or extent of growth hormone activity.


negative regulation of mRNA cap binding

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cap binding.


negative regulation of core promoter binding

Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding.


regulation of microtubule minus-end binding

Any process that modulates the frequency, rate or extent of microtubule minus-end binding.


negative regulation of collagen binding

Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding.


negative regulation of G-quadruplex DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA binding.


regulation of G-quadruplex DNA binding

Any process that modulates the frequency, rate or extent of G-quadruplex DNA binding.


regulation of single-stranded telomeric DNA binding

Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA.


regulation of chemokine activity

Any process that modulates the frequency, rate or extent of chemokine activity.


negative regulation of RNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding.


regulation of actin filament binding

Any process that modulates the frequency, rate or extent of actin filament binding.


regulation of apolipoprotein binding

Any process that modulates the frequency, rate or extent of apolipoprotein binding.


regulation of triplex DNA binding

Any process that modulates the frequency, rate or extent of triplex DNA binding.


negative regulation of telomeric DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding.


negative regulation of mRNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA binding.


regulation of DNA replication origin binding

Any process that modulates the frequency, rate or extent of DNA replication origin binding.


negative regulation of euchromatin binding

Any process that stops, prevents or reduces the frequency, rate or extent of euchromatin binding.


negative regulation of actin filament binding

Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding.


regulation of substance P receptor binding

Any process that modulates the frequency, rate or extent of substance P receptor binding.


negative regulation of DNA replication origin binding

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding.


regulation of heparan sulfate binding

Any process that modulates the frequency, rate or extent of heparan sulfate binding.


regulation of growth hormone activity

Any process that modulates the frequency, rate or extent of growth hormone activity.


negative regulation of small GTPase binding

Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase binding.


regulation of double-stranded telomeric DNA binding

Any process that modulates the frequency, rate or extent of double-stranded telomeric DNA binding.


negative regulation of heparan sulfate binding

Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate binding.


negative regulation of polysome binding

Any process that stops, prevents or reduces the frequency, rate or extent of polysome binding.


regulation of euchromatin binding

Any process that modulates the frequency, rate or extent of euchromatin binding.


regulation of lipid binding

Any process that modulates the frequency, rate or extent of lipid binding.


regulation of mRNA 3'-UTR binding

Any process that modulates the frequency, rate or extent of mRNA 3'-UTR binding.


regulation of guanyl-nucleotide exchange factor activity

Any process that modulates the frequency, rate or extent of guanyl-nucleotide exchange factor activity.


negative regulation of mRNA 3'-UTR binding

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-UTR binding.


modulation by host of RNA binding by virus

A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA.


regulation of recombination hotspot binding

Any process that modulates the frequency, rate or extent of recombination hotspot binding.


negative regulation of ferrous iron binding

Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron binding.


negative regulation of heparan sulfate proteoglycan binding

Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate proteoglycan binding.


regulation of RNA polymerase I regulatory region sequence-specific DNA binding

Any process that modulates the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding.


negative regulation of microtubule plus-end binding

Any process that stops, prevents or reduces the frequency, rate or extent of microtubule plus-end binding.


regulation of low-density lipoprotein particle receptor binding

Any process that modulates the frequency, rate or extent of low-density lipoprotein particle receptor binding.


regulation of RNA binding

Any process that modulates the frequency, rate or extent of RNA binding.


negative regulation of triplex DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of triplex DNA binding.


negative regulation of GTP binding

Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding.


negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding

Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding.


dishabituation

The temporary recovery of response to a stimulus when a novel stimulus is added.


geranylfarnesyl diphosphate synthase activity

Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate.


D-allose biosynthetic process

The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose.


3,8-divinyl protochlorophyllide a 8-vinyl reductase activity

Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+.


Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H+ + UDP-N-acetyl-D-galactosamine 4,6-disulfate.


Iris Implantation Cyst

A cyst that arises from the iris and is lined by squamous epithelium.


CD8-positive, alpha-beta cytotoxic T cell extravasation

The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue.


CD8-positive, alpha-beta T cell extravasation

The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue.


T-helper 1 cell extravasation

The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.


T-helper 17 cell extravasation

The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue.


negative regulation of retrograde dense core granule transport

Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport.


site of DNA damage

A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


cellular response to streptomycin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome.


ABC-type quaternary ammonium compound transporting activity

Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in).


ABC-type glycine betaine transporter activity

Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out).


glycine betaine:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in).


quaternary ammonium group:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in).


(R)-carnitine transmembrane transporter activity

Enables the transfer of (R)-carnitine from one side of a membrane to the other.


acyl carnitine transmembrane transporter activity

Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane.


glycine betaine:sodium:chloride symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in).


ATPase-coupled hydroxyectoine transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out).


N-methylnicotinate transmembrane transporter activity

Enables the transfer of N-methylnicotinate from one side of a membrane to the other.


4-(trimethylammonio)butanoate transmembrane transporter activity

Enables the transfer of 4-(trimethylammonio)butanoate from one side of a membrane to the other.


oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen.


carbonyl sulfide nitrogenase activity

Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide.


glucosylceramide biosynthetic process

The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.


deep auricular artery

The deep auricular artery often arises in common with the anterior tympanic artery. It ascends in the substance of the parotid gland, behind the temporomandibular articulation, pierces the cartilaginous or bony wall of the external acoustic meatus, and supplies its cuticular lining and the outer surface of the tympanic membrane. It gives a branch to the temporomandibular joint.


negative regulation of chaperone-mediated protein folding

Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding.


Excessive Bleeding

Abnormally heavy or prolonged loss of blood.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in).


low-affinity sulfate:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.


high-affinity sulfate:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


high-affinity sulfate transmembrane transporter activity

Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations.


cobinamide phosphate guanylyltransferase activity

Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate.


peptidoglycan peptide transmembrane transporter activity

Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains.


choloyl-CoA hydrolase activity

Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA.


postsynaptic modulation of chemical synaptic transmission

Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.


adult somatic muscle development

The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure.


larval somatic muscle development

The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.


gentisate 1,2-dioxygenase activity

Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H+.


Adult Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm, occurring in adults.  It is characterized by a proliferation of neoplastic spindle cells.


Penile Leiomyosarcoma

A leiomyosarcoma that occurs in the penis.


Unresectable Leiomyosarcoma

A leiomyosarcoma which is not amenable to surgical resection.


Dedifferentiated Leiomyosarcoma

A pleomorphic leiomyosarcoma that lacks immunohistochemical staining for myogenic markers in the pleomorphic areas.


Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8

Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Pancreatic Leiomyosarcoma

A rare leiomyosarcoma that arises from the pancreas.


Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8

Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage I Uterine Corpus Leiomyosarcoma AJCC v8

Stage I includes: T1, N0, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IV Uterine Corpus Leiomyosarcoma AJCC v8

Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus leiomyosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Primary leiomyosarcoma

Leiomyosarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


EBV-Related Leiomyosarcoma

Leiomyosarcoma that is caused by Epstein-Barr virus infection.


Inferior Vena Cava Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm, arising from the inferior vena cava.  It is characterized by a proliferation of neoplastic spindle cells.


Metastatic leiomyosarcoma

A leiomyosarcoma that has spread to other anatomic sites.


leiomyosarcoma of appendix

A rare leiomyosarcoma that arises from the appendiceal wall.


Unresectable Soft Tissue Leiomyosarcoma

A soft tissue leiomyosarcoma that is not amenable to surgical resection.


Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8

Stage IVA includes: T4, Any N, M0. T4: Uterine corpus leiomyosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Conjunctival Leiomyosarcoma

A leiomyosarcoma that arises from the conjunctiva.


Seminal Vesicle Leiomyosarcoma

A rare leiomyosarcoma that affects the seminal vesicle.


Stage IB Uterine Corpus Leiomyosarcoma AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Uterine corpus leiomyosarcoma with tumor limited to the uterus, measuring more than 5 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Pleomorphic leiomyosarcoma

A leiomyosarcoma characterized by the presence of poorly differentiated areas with pleomorphic appearance, in addition to areas with typical morphologic features.


Leiomyosarcoma NCI Grade 2

A leiomyosarcoma with less than 15% necrosis.


Refractory Leiomyosarcoma

Leiomyosarcoma that does not respond to treatment.


Leiomyosarcoma of Vessels

An aggressive malignant smooth muscle neoplasm, arising from the walls of the vascular system.  It is characterized by a proliferation of neoplastic spindle cells.


leiomyosarcoma of bladder

A leiomyosarcoma that arises from the bladder. It is the most common type of bladder sarcoma in adults.


Broad Ligament Leiomyosarcoma

A rare leiomyosarcoma that arises from the broad ligament.


Unresectable Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that is not amenable to surgical resection.


Advanced Soft Tissue Leiomyosarcoma

A soft tissue leiomyosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8

Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Uterine Corpus Leiomyosarcoma by AJCC v8 Stage

A term that refers to the staging of uterine corpus leiomyosarcoma according to the American Joint Committee on Cancer, 8th edition.


Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8

Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. T2: Uterine corpus leiomyosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Childhood Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm, occurring in children.  It is characterized by a proliferation of neoplastic spindle cells.


Leiomyosarcoma recurrent

The reemergence of leiomyosarcoma after a period of remission


Locally Recurrent Uterine Corpus Leiomyosarcoma

The reemergence of uterine corpus leiomyosarcoma after a period of remission, at or adjacent to the site of the original tumor.


Stage III Uterine Corpus Leiomyosarcoma AJCC v8

Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. T2: Uterine corpus leiomyosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Thyroid Gland Leiomyosarcoma

A leiomyosarcoma that arises from the thyroid gland.


Metastatic Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that has spread from its original site of growth to another anatomic site.


Locally Advanced Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that has spread to nearby tissues or lymph nodes.


Colorectal Leiomyosarcoma

An aggressive malignant smooth muscle neoplasm that arises from the colon or rectum.  It is characterized by a proliferation of neoplastic spindle cells.


Metastatic Soft Tissue Leiomyosarcoma

A soft tissue leiomyosarcoma that has spread from the original site of growth to another anatomic site.


Sinonasal Leiomyosarcoma

A leiomyosarcoma that arises from the nasal cavity and paranasal sinuses.


Well Differentiated Leiomyosarcoma

Grade I malignant smooth muscle neoplasm.  It is characterized by a proliferation of neoplastic spindle cells.


Stage IA Uterine Corpus Leiomyosarcoma AJCC v8

Stage IA includes: T1a, N0, M0. T1a: Uterine corpus leiomyosarcoma with tumor limited to the uterus, measuring 5 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Digestive System Leiomyosarcoma

A leiomyosarcoma arising from an anatomic site in the digestive system.


Resectable Leiomyosarcoma

Leiomyosarcoma that is amenable to surgical resection.


Advanced Leiomyosarcoma

A leiomyosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Soft Tissue Leiomyosarcoma

Soft tissue leiomyosarcoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Leiomyosarcoma

A leiomyosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Leiomyosarcoma of Deep Soft Tissue

A rare leiomyosarcoma that arises from the deep soft tissue in the retroperitoneum or abdominal cavity.


phagolysosome assembly involved in apoptotic cell clearance

The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance.


inositol 5-diphosphate pentakisphosphate 5-kinase activity

Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate.


pectoral appendage

Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues.


archipterygial fin

A type of pectoral fin in which the endoskeletal elements have a main axis that runs through the center of the fin. This creates a bilaterally symmetrical fin. (Modified from Kardong 2012).


pectoral fin

Paired fin that is located in the thoracic region of the body.


6-hydroxynicotinate reductase activity

Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin.


Refractory Malignant Soft Tissue Neoplasm

Malignant soft tissue neoplasm that is resistant to treatment.


thiocyanate hydrolase activity

Catalysis of the reaction: H2O + 2 H+ + thiocyanate = carbonyl sulfide + NH4.


Digestive System Solitary Fibrous Tumor

A solitary fibrous tumor arising from an anatomic site in the digestive system, including the esophagus, gallbladder, liver, pancreas, small bowel mesentery, and the serosal surfaces of the stomach and colon.


Skin tumor of smooth muscle origin

A smooth muscle neoplasm occurring in the skin.


Pilar Leiomyoma

A cutaneous leiomyoma arising from the arrector pili muscle.


skeletal muscle tissue of pectoralis major

A portion of skeletal muscle tissue that is part of a pectoralis major [Automatically generated definition].


Proximal Circumflex Artery

The section of the left circumflex coronary artery that arises from the left main coronary artery and extends to the first marginal branch.


Refractory Paraganglioma

A paraganglioma that does not respond to treatment.


Refractory Adrenal Gland Pheochromocytoma

A pheochromocytoma that does not respond to treatment.


Stage IB Uterine Corpus Cancer AJCC v8

Stage IB includes: T1b, N0, M0. T1b: Uterine corpus carcinoma or carcinosarcoma with tumor invading one half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


cyclic-GMP-AMP hydrolase activity

Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP.


interlobular bile duct

The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad.


A member of the class of benzofurans consisting of a 1-benzofuran skeleton and its substituted derivatives thereof.


broad specificity neutral L-amino acid:basic L-amino acid antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out).


Catalysis of the reaction: S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out).


monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential

Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out).


Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out).


amino acid:monoatomic cation antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc.


aspartate:glutamate, proton antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-aspartate(in) + L-glutamate(out) = H+(in) + L-aspartate(out) + L-glutamate(in).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out).


Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out).


Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out).


ATP:inorganic phosphate antiporter activity

Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + inorganic phosphate(in) = ATP(in) + inorganic phosphate(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out).


Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out).


bicarbonate:monoatomic anion antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in).


Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out).


calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + H+(in) = glycine(in) + H+(out).


gamma-aminobutyric acid:proton antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out).


Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out).


Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out).


metal cation:monoatomic cation antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out).


ADP:inorganic phosphate antiporter activity

Enables the transfer of ADP from one side of a membrane to the other according to the reaction: ADP(out) + inorganic phosphate(in) = ADP(in) + inorganic phosphate(out).


monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential

Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.


Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out).


Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out).


urate:monoatomic anion antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out).


glutamate:gamma-aminobutyric acid antiporter activity

Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out).


3-sulfino-L-alanine: proton, glutamate antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-sulfino-L-alanine (cysteinesulfinate) (out) + H+(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H+(out) + L-glutamate(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out).


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out).


Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in).


polyspecific organic cation:proton antiporter activity

Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics.