aminoglycoside antibiotic catabolic process

The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin.


ergosteryl 3-beta-D-glucoside catabolic process

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The chemical reactions and pathways resulting in the breakdown of ergosteryl 3-beta-D-glucoside.


N-acetylmannosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose.


mannosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins.


mannoprotein catabolic process

The chemical reactions and pathways resulting in the breakdown of a mannoprotein, a protein that contains covalently bound mannose residues.


teichoic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues.


heparin catabolic process

The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


lipooligosaccharide catabolic process

The chemical reactions and pathways resulting in the breakdown of lipooligosaccharide.


saponin catabolic process

The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection.


beta-glucoside catabolic process

The chemical reactions and pathways resulting in the breakdown of beta-glucoside.


zeaxanthin bis(beta-D-glucoside) catabolic process

The chemical reactions and pathways resulting in the breakdown of zeaxanthin bis(beta-D-glucoside).


elastin catabolic process

The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue.


fructosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.


U12-type post-mRNA release spliceosomal complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs.


U12-type prespliceosome

A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.


U12-type precatalytic spliceosome

A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs.


U12-type post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U12 and U6atac.


U2-type post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6.


U12-type catalytic step 2 spliceosome

A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs.


U2-type precatalytic spliceosome

A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.


trans spliceosomal complex

A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates.


U12-type catalytic step 1 spliceosome

A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs.


U2-type catalytic step 2 spliceosome

A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.


biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A reactive cutaneous proliferation of macrophages. It is characterized by the presence of giant cells with ground-glass cytoplasm. It presents with multiple cutaneous or mucosal papules or nodules.


negative regulation of establishment of endothelial barrier

Any process that stops, prevents or reduces the frequency, rate or extent of establishment of endothelial barrier.


organ system subdivision

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A subdivision of an anatomical system.


insect embryonic/larval central nervous system

Central nervous system of the embryo/larva.


insect adult central nervous system

Central nervous system of the adult.


subdivision of skeletal system

Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.


subdivision of skeleton

Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.


musculature

A subdivision of the muscular system corresponding to a subdisivision of an organism.


meckelian bone

The ossification of the Meckel's cartilage.


Epididymal Melanotic Neuroectodermal Tumor

A rare neoplasm that arises from the epididymis and is characterized by the presence of a mixture of melanin-containing epithelial cells and smaller neuroblast-like cells. It usually occurs in infants and has a benign clinical course.


ATP-dependent H2AZ histone chaperone activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite.


maltose transporting porin activity

Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.


insulin-like growth factor binary complex

A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development.


regulation of telomeric loop disassembly

Any process that modulates the frequency, rate or extent of telomeric loop disassembly.


positive regulation of telomeric D-loop disassembly

Any process that activates or increases the frequency, rate or extent of telomeric D-loop disassembly.


positive regulation of telomeric loop disassembly

Any process that activates or increases the frequency, rate or extent of telomeric loop disassembly.


regulation of telomeric D-loop disassembly

Any process that modulates the frequency, rate or extent of telomeric D-loop disassembly.


left anterior cardinal vein

An anterior cardinal vein that is in_the_left_side_of a multicellular organism.


cardinal vein

Any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column.


left posterior cardinal vein

A posterior cardinal vein that is in_the_left_side_of a multicellular organism.


posterior cardinal vein

One of two paired cardinal veins that return blood from the body of the embryo[Kardong].


common cardinal vein

Either of a pair of large transverse venous sinuses that conduct blood from the cardinal veins to the sinus venosus of the vertebrate embryo[BTO].


right posterior cardinal vein

A posterior cardinal vein that is in_the_right_side_of a multicellular organism.


right anterior cardinal vein

An anterior cardinal vein that is in_the_right_side_of a multicellular organism.


anterior cardinal vein

One of the the two paired cardinal veins draining the cephalic part of the body.


facial nerve neoplasm

A neoplasm involving a facial nerve.


geniculate ganglionitis

Diseases of the facial nerve or nuclei. Pontine disorders may affect the facial nuclei or nerve fascicle. The nerve may be involved intracranially, along its course through the petrous portion of the temporal bone, or along its extracranial course. Clinical manifestations include facial muscle weakness, loss of taste from the anterior tongue, hyperacusis, and decreased lacrimation.


geniculate herpes zoster

A viral ear infection caused by the spread of varicella-zoster virus to the facial nerves. It is characterized by intense otalgia and a cutaneous vesicular eruption.


Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome

This syndrome is characterized by the association of MC6bius syndrome (congenital facial palsy with impaired ocular abduction) with peripheral axonal neuropathy and hypogonadotropic hypogonadism.


familial isolated deficiency of vitamin E

Ataxia with vitamin E deficiency (AVED) is a neurodegenerative disease belonging to the inherited cerebellar ataxias. It is mainly characterized by progressive spino-cerebellar ataxia, loss of proprioception, areflexia, and is associated with a marked deficiency in vitamin E.


hypertriglyceridemia 1

A laboratory test result indicating an autosomal dominant condition in which there is increased very low density lipoprotein production, which leads to increased triglyceride concentration.


positive regulation of pheromone response MAPK cascade

Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade.


positive regulation of ERK5 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.


positive regulation of cell wall integrity MAPK cascade

Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis.


tRNA A64-2'-O-ribosylphosphate transferase activity

Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA.


female somatic sex determination

The determination of sex and sexual phenotypes in a female organism's soma.


NIK deficiency

A immunodeficiency disorder caused by loss of function mutation in NIK (MAP3K14).


plasma membrane proton-transporting V-type ATPase, V0 domain

The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane.


lysosomal proton-transporting V-type ATPase, V0 domain

The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.


transient retinal arterial occlusion

A partial, temporary occlusion of the retinal artery.


arterial disorder

An impairment of the structure or function of the blood vessels which carry blood away from the heart.


Hepatic Arterial Occlusion

An occlusion of the hepatic artery.


Efferent Arteriolar Hyalinosis

The deposition of hyaline material in the wall of the efferent arterioles.


Systemic Arterial Hypertensive Disorder

Any condition resulting in systemically elevated blood pressure that is attributed to an arterial source.


coronary atherosclerosis

Atherosclerosis of the coronary vasculature.


Three Vessel Coronary Disease

There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in three coronary arteries (or greater than or equal to 50% stenosis in the left main coronary artery and greater than or equal to 50% stenosis in the right coronary artery). (ACC)


generalized atherosclerosis

Atherosclerosis that is not localized.


arterial occlusion

Complete closure of the normally patent lumen of the blood vessels which carry blood away from the heart.


partial arterial retinal occlusion

A partial occlusion of the retinal artery.


Infectious Arteritis

A bacterial or viral infectious process affecting an artery.


Overlap Necrotizing Arteritis

A necrotizing arteritis that exhibits characteristic features of several distinct vascular disorders.


vasculitis due to ADA2 deficiency

Vasculitis due to ADA2 deficiency is a rare, genetic, systemic and rheumatologic disease due to adenosine deaminase-2 inactivating mutations, combining variable features of autoinflammation, vasculitis, and a mild immunodeficiency. Variable clinical presentation includes chronic or recurrent systemic inflammation with fever, livedo reticularis or racemosa, early-onset ischemic or hemorrhagic strokes, peripheral neuropathy, abdominal pain, hepatosplenomegaly, portal hypertension, cutaneous polyarteritis nodosa, variable cytopenia and immunoglobulin deficiency.


microscopic polyangiitis

Microscopic polyangiitis (MPA) is an inflammatory, necrotizing, systemic vasculitis that affects predominantly small vessels (i.e. small arteries, arterioles, capillaries, venules) in multiple organs.


Double coronary vessel disease

There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in two coronary arteries (or greater than or equal to 50% stenosis in the left main coronary artery). (ACC)


cerebral atherosclerosis

Atherosclerosis of the cerebral vasculature.


arteriolosclerosis

The thickening of the wall of the small arteries and arterioles. It is caused by deposition of hyaline material in the wall or concentric smooth muscle wall hypertrophy. It results in lumen narrowing and tissue ischemia.


Monckeberg arteriosclerosis

A type of arteriosclerosis in which calcification of the tunica media is the predominant feature.


One Vessel Coronary Disease

There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in one coronary artery. (ACC)


cutaneous polyarteritis nodosa

Cutaneous polyarteritis nodosa (CPAN) is a rare limited form of polyarteritis nodosa (PAN), characterized by cutaneous vasculitis and mild and transient extracutaneous manifestations such as mild arthralgia, arthritis,myalgia, and rarely peripheral neuropathy.


Generalised arteriosclerosis

Arteriosclerosis that is not localized.


Significant Arterial Dissection

A dissection that impairs flow. This includes Type C (a persisting contrast medium extravasation) in the presence of ischemia, Type D (a spiral filling defect with delayed but complete distal flow), Type E (persistent filling defect with delayed antegrade flow) and Type F (filling defect with impaired flow and total occlusion).


Hyaline arteriolosclerosis

The deposition of hyaline material in the wall of the arterioles.


granulomatous angiitis

Inflammation of the arteries that is characterized by the presence of granulomas.


Femoropopliteal Occlusive Disease

An occlusive disease of the femoropopliteal vascular system.


endarteritis

Inflammation of the arterial intima.


chorionic trophoblast cell proliferation

The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population.


Lung Radiation Injury

Radiation injury of the pulmonary system.


middle ear cholesterol granuloma

As accumulation of granulation tissue in the middle ear that results from the degeneration of blood and a chronic inflammatory response.


Cholesterol granuloma

A cystic inflammatory lesion that is comprised of fluids, lipids, and cholesterol crystals, and which is surrounded by a fibrous lining.


mycothiol biosynthetic process

The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione.


Bronchospasm, Exercise-Induced

Sudden contraction of the smooth muscles of the bronchial wall that occurs during or following exercise.


Drug-induced cutaneous lupus erythematosus

A reaction to a drug characterized by skin findings common to lupus including photosensitivity and butterfly rash; typically it resolves after drug discontinuation.


lupus erythematosus tumidus

Tumid erythematosus lupus is considered a rare type of chronic cutaneous lupus erythematosus. Cutaneous lupus erythematosus (CLE) can be divided into acute cutaneous lupus, subacute cutaneous lupus, and chronic cutaneous lupus. Tumid erythematosus lupus is characterized by smooth, non-scarring, pink- to violet-colored pimples (papules)on the skin without any other apparent skin changes, such as scarring. Patients with tumid lupus erythematosus usually do not have other symptoms of systemic lupus erythematosus or other types of cutaneous lupus erythematosus. The papules appear on sun-exposed areas of the face, upper back, V area of the neck, trunk, and arms, and more rarely on thighs and legs. They usually affect equally both sides of the body, but may affect only one side. Normally, the papules clear without leaving scars. The treatment is very effective in most cases, and may include sun protection, anti-malarials drugs, local corticosteroids, topical tacrolimus and light therapy.


subacute cutaneous lupus erythematosus

Subacute cutaneous lupus erythematosus (SCLE) is a form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. SCLE is associated with anti-Ro/SSA antibodies and can be drug-induced.


deoxyuridine biosynthetic process

The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA.


1,1,2-trichloroethene reductive dehalogenase activity

Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene.


Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+.


skin of manus

A zone of skin that is part of a manus [Automatically generated definition].


manual digit skin

A zone of skin that is part of a finger [Automatically generated definition].


skin of wrist

A zone of skin that is part of a wrist [Automatically generated definition].


cellular response to external biotic stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.


anatomical group

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Anatomical structure consisting of at least two non-overlapping organs, multi-tissue aggregates or portion of tissues or cells of different types that does not constitute an organism, organ, multi-tissue aggregate, or portion of tissue.


clear cell sarcoma

A rare malignant neoplasm with melanocytic differentiation characterized by the presence of polygonal or spindle shaped clear cells. This sarcoma usually affects the tendons and aponeuroses and is associated with a poor prognosis due to recurrences and metastases.


Childhood Clear Cell Sarcoma of Soft Parts

A clear cell sarcoma of soft tissue occurring in children.


Metastatic Clear Cell Sarcoma of Soft Tissue

A clear cell sarcoma of soft tissue that has spread from the original site of growth to other anatomic sites.


Advanced Clear Cell Sarcoma of Soft Tissue

A clear cell sarcoma of soft tissue that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Clear Cell Sarcoma of Soft Tissue

The reemergence of clear cell sarcoma of soft tissue after a period of remission.


Refractory Clear Cell Sarcoma of Soft Tissue

Clear cell sarcoma of soft tissue that is resistant to treatment.


COG4-congenital disorder of glycosylation

COG4-CDG is an extremely rare form of CDG syndrome characterized clinically in the single reported case to date by seizures, some dysmorphic features, axial hyponia, slight peripheral hypertonia and hyperreflexia.


lateral motor column neuron differentiation

The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate.


primary cutaneous gamma/delta-positive T-cell lymphoma

Primary cutaneous gamma/delta-positive T-cell lymphoma is a rare, usually aggressive, subtype of cutaneous T-cell lymphoma characterized by infiltration of the epidermis, dermis or subcutaneous tissue by a clonal population of mature, gamma/delta positive cytotoxic T-cells. Typically it presents with ulcerating plaques, tumors, or subcutaneous nodules on the skin of the extremities, however, frequent involvement of mucosal and extranodal sites (such as the nasal cavity, gastrointestinal tract or lungs) is also observed. Cases associated with panniculitis may present with hemophagocytic syndrome (abrupt onset of fever, rash, cytopenia, hepatosplenomegaly and neurological compromise). Infiltration of lymph nodes, spleen and bone marrow is uncommon and resistance to multilineage chemotherapy is reported.


reactive gliosis

A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells.


Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine.


glycine dehydrogenase (decarboxylating) activity

Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.


oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group.


cardioblast migration to the midline involved in heart rudiment formation

The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment.


Locally Advanced Unresectable Gastric Adenocarcinoma

A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Metastatic Unresectable Carcinoma

A carcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


Metastatic Unresectable Basal Cell Carcinoma

A basal cell carcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


Locally Advanced Unresectable Esophageal Adenocarcinoma

Esophageal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Colorectal Adenocarcinoma

A colorectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Pancreatic Adenocarcinoma

A pancreatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Metastatic Unresectable Gastric Adenocarcinoma

A gastric adenocarcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


Locally Advanced Unresectable Triple-Negative Breast Carcinoma

Triple-negative breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Colon Adenocarcinoma

A colon adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Basal Cell Carcinoma

A basal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Carcinoma

A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Prostate Adenocarcinoma

A prostatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Breast Carcinoma

A breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Unresectable Castration-Resistant Prostate Carcinoma

Castration-resistant prostate carcinoma that is not amenable to surgical resection.


Locally Advanced Unresectable Renal Cell Carcinoma

A renal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable HER2-Negative Breast Carcinoma

HER2-negative breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Cervical Adenocarcinoma

A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Lung Non-Small Cell Squamous Carcinoma

A non-small cell squamous carcinoma of the lung that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable HER2-Positive Breast Carcinoma

HER2-positive breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Fallopian Tube Carcinoma

Fallopian tube carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma

Hormone receptor-positive breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Prostate Carcinoma

A prostatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Cervical Carcinoma

A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Stage IA Uterine Sarcoma AJCC v7

Stage IA includes: T1a, N0, M0.  T1a: For leiomyosarcoma and endometrial stromal sarcoma: tumor 5 cm or less in greatest dimension.  For adenosarcoma: tumor limited to endometrium/endocervix.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis.


negative regulation of planar cell polarity pathway involved in heart morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis.


negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis.


negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis.


negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis.


negative regulation of planar cell polarity pathway involved in pericardium morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis.


P2Y5 nucleotide receptor binding

Binding to a P2Y5 nucleotide receptor.


tonsil neoplasm

A neoplasm (disease) that involves the tonsil.


benign neoplasm of tonsil

A benign neoplasm that involves the tonsil.


tonsillar lipoma

A benign adipose tissue neoplasm of the tonsils.


cystic vein

A blood vessel carrying deoxygenated blood from the gallbladder and the cystic duct into the right branch of the portal vein.


formamide biosynthetic process

The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid.


D-tagatose 6-phosphate metabolic process

The chemical reactions and pathways involving a D-tagatose 6-phosphate.


Eccrine angiomatous hamartoma

A rare, congenital skin lesion consisting of a proliferation of eccrine glands with a vascular stroma. It presents as a flesh-colored, hyperhidrotic, painful papule or plaque appearing at birth or during childhood.


peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine

The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine.


plantar fibromatosis

A superficial fibromatosis arising from soft tissue of the plantar regions. It is characterized by the presence of spindle-shaped fibroblasts, hypercellularity, and an infiltrative growth pattern.


lateral mesoderm morphogenesis

The process in which the anatomical structures of the lateral mesoderm are generated and organized.


succinate-CoA ligase complex (GDP-forming)

A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.


mitochondrial isocitrate dehydrogenase complex (NAD+)

Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity.


mitochondrial oxoglutarate dehydrogenase complex

A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus.


Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O.


regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


regulation of heterochromatin formation

Any process that modulates the frequency, rate, extent or location of heterochromatin formation.


positive regulation of mating-type specific transcription, DNA-templated

Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription.


regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts

Any process that modulates the rate, frequency, or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein.


siRNA-mediated gene silencing by mRNA destabilization

An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.


regulation of ncRNA transcription

Any process that modulates the frequency, rate or extent of transcription of a non-protein coding gene from a DNA-template.


regulation of ethylene biosynthetic process

Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process.


positive regulation of cellular biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.


negative regulation of methyl-branched fatty acid biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of methyl-branched fatty acid biosynthetic process.


regulation of reticulophagy

Any process that modulates the frequency, rate or extent of reticulophagy.


regulation of mitotic cell cycle DNA replication

Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication.


regulation of antibacterial peptide secretion

Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion.


regulation of antifungal peptide secretion

Any process that modulates the frequency, rate, or extent of antifungal peptide secretion.


negative regulation of interleukin-1 alpha production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production.


negative regulation of carotenoid biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of carotenoid biosynthetic process.


positive regulation of vitamin E biosynthetic process

Any process that activates or increases the frequency, rate or extent of vitamin E biosynthetic process.


negative regulation of macrophage colony-stimulating factor production

Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor production.


regulation of cell wall (1->3)-beta-D-glucan biosynthetic process

Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells.


suppression by virus of host gene expression

Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.


programmed DNA elimination by elimination of internal DNA segments

A programmed DNA elimination mechanism in which specific sequences, namely, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the genome. This process is known to occur in ciliates.


negative regulation of interleukin-37 production

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 production.


transitive RNA interference

An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence.


epigenetic programming in the central cell

The establishment of epigenetic modifications (imprints) in a plant central cell, leading to an asymmetry between the two maternal alleles and the paternal allele, and differential expression of the corresponding alleles in the developing endosperm. This can happen through heterochromatin formation or differential chromatin loop formation.


regulation of phosphatidylserine metabolic process

Any process that modulates the frequency, rate or extent of phosphatidylserine metabolic process.


regulation of aggrephagy

Any process that modulates the frequency, rate or extent of aggrephagy.


positive regulation of methane biosynthetic process from trimethylamine

Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from trimethylamine.


regulation of restriction endodeoxyribonuclease activity

Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.


nitrogen catabolite regulation of transcription

A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


regulation of ent-pimara-8(14),15-diene biosynthetic process

Any process that modulates the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process.


positive regulation of interleukin-21 production

Any process that activates or increases the frequency, rate, or extent of interleukin-21 production.


regulation of siRNA-dependent facultative heterochromatin formation

Any process that modulates the frequency, rate or extent of siRNA-dependent facultative heterochromatin formation.


negative regulation of interleukin-26 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production.


positive regulation of chlorophyll catabolic process

Any process that activates or increases the frequency, rate or extent of chlorophyll catabolic process.


negative regulation of (+)-kotanin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of (+)-kotanin biosynthetic process.


suppression by virus of host PKR signaling

Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response.


regulation of interleukin-34 production

Any process that modulates the frequency, rate or extent of interleukin-34 production.


regulation of error-prone translesion synthesis

Any process that modulates the frequency, rate or extent of error-prone translesion synthesis.


siRNA-mediated facultative heterochromatin formation

The formation of facultative heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a small interfering RNA.


positive regulation of macromolecule biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


negative regulation of violaceol II biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of violaceol II biosynthetic process.


regulation of violaceol I biosynthetic process

Any process that modulates the frequency, rate or extent of violaceol I biosynthetic process.


regulation of cytochrome-c oxidase activity

Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity.


positive regulation of (1->3)-beta-D-glucan biosynthetic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans.


positive regulation of diacylglycerol kinase activity

Any process that activates or increases the frequency, rate or extent of diacylglycerol kinase activity.


negative regulation of chemokine (C-X-C motif) ligand 1 production

Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production.


nitrogen catabolite activation of transcription

A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


tRNA destabilization

Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes.


induction by virus of host autophagy

Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.


regulation of mitochondrial ATP synthesis coupled electron transport

Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport.


positive regulation of glycolytic process through fructose-6-phosphate

Any process that activates or increases the frequency, rate or extent of glycolytic process through fructose-6-phosphate.


regulation of interleukin-15 production

Any process that modulates the frequency, rate, or extent of interleukin-15 production.


silent mating-type cassette heterochromatin formation

Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.


negative regulation of transforming growth factor beta3 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3.


regulation of RNA polymerase III activity

Any process that modulates the frequency, rate or extent of RNA polymerase III activity.


regulation of regulatory ncRNA-mediated heterochromatin formation

Any process that modulates the frequency, rate or extent of small non-coding RNA-mediated heterochromatin formation.


positive regulation of hydrogen peroxide biosynthetic process

Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.


regulation of type III site-specific deoxyribonuclease activity

Any process that modulates the frequency, rate or extent of a type III restriction endodeoxyribonuclease activity.


negative regulation of natural killer cell cytokine production

Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production.


regulation of vitamin A metabolic process

Any process that modulates the frequency, rate or extent of vitamin A metabolic process.


regulation of amylopectin catabolic process

Any process that modulates the frequency, rate or extent of amylopectin catabolic process.


positive regulation of telomere maintenance in response to DNA damage

Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage.


positive regulation of antimicrobial peptide secretion

Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion.


positive regulation of juvenile hormone catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone.


positive regulation of myeloid dendritic cell cytokine production

Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.


regulation of interleukin-11 production

Any process that modulates the frequency, rate, or extent of interleukin-11 production.


negative regulation of interleukin-34 production

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production.


regulation of pectin biosynthetic process

Any process that modulates the frequency, rate or extent of pectin biosynthetic process.


negative regulation of cellular metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


regulation of interleukin-33 production

Any process that modulates the frequency, rate or extent of interleukin-33 production.


regulation of chemokine (C-C motif) ligand 4 production

Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4.


regulation of interleukin-37 production

Any process that modulates the frequency, rate or extent of interleukin-37 production.


positive regulation of type III interferon production

Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.


negative regulation of syringal lignin catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin catabolic process.


positive regulation of chemokine (C-C motif) ligand 1 production

Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1.


negative regulation of interleukin-16 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production.


regulation of 4,6-pyruvylated galactose residue biosynthetic process

Any process that modulates the rate, frequency, or extent of 4,6-pyruvylated galactose residue biosynthetic process, the chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-(1->3)-. The galactose residue is part of a larger polysaccharide chain.


lncRNA-mediated post-transcriptional gene silencing

A post-transcriptional gene silencing pathway in which regulatory long noncoding RNAs (lncRNAs) elicit silencing of specific target genes, often miRNAs or mRNAs.


positive regulation of ergosterol biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.


positive regulation of aggrephagy

Any process that activates or increases the frequency, rate or extent of aggrephagy.


siRNA-mediated long-distance post-transcriptional gene silencing

An siRNA-mediated posttranscriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs, and in which the silencing signal originates in one tissue and occurs in a different tissue.


negative regulation of cardiolipin metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of cardiolipin metabolic process.


positive regulation of 3'-UTR-mediated mRNA stabilization

Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.


regulation of cell wall chitin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin.


regulation of DNA strand resection involved in replication fork processing

Any process that modulates the frequency, rate or extent of DNA strand resection involved in replication fork processing.


positive regulation of bile acid metabolic process

Any process that activates or increases the frequency, rate or extent of bile acid metabolic process.


regulation of pyrimidine nucleotide biosynthetic process

Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthetic process.


regulation of siRNA processing

Any process that modulates the frequency, rate or extent of siRNA processing.


negative regulation of UDP-glucose catabolic process

Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.


regulation of double-strand break repair via break-induced replication

Any process that modulates the frequency, rate or extent of double-strand break repair via break-induced replication.


positive regulation of interleukin-7 production

Any process that activates or increases the frequency, rate, or extent of interleukin-7 production.


negative regulation of interleukin-20 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production.


negative regulation of interleukin-24 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production.


positive regulation of single strand break repair

Any process that activates or increases the frequency, rate or extent of single strand break repair.


positive regulation of post-transcriptional gene silencing by RNA

Any process that activates or increases the frequency, rate or extent of post-transcriptional gene silencing by RNA.


negative regulation of sarcinapterin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin biosynthetic process.


piRNA-mediated retrotransposon silencing by heterochromatin formation

A retrotransposon silencing mechanism in which a piRNA triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.


regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.


positive regulation of fractalkine production

Any process that activates or increases the frequency, rate, or extent of fractalkine production.


negative regulation of cytochrome-c oxidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of cytochrome-c oxidase activity.


regulation of lignin biosynthetic process

Any process that modulates the frequency, rate or extent of lignin biosynthetic process.


regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process

Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process.


regulation of toluene catabolic process

Any process that modulates the frequency, rate or extent of toluene catabolic process.


regulation of antimicrobial peptide secretion

Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion.


negative regulation of granzyme A production

Any process that stops, prevents or reduces the frequency, rate or extent of granzyme A production.


positive regulation of strand invasion

Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.


negative regulation of methane biosynthetic process from trimethylamine

Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from trimethylamine.


negative regulation of beta 2 integrin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.


negative regulation of diacylglycerol kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol kinase activity.


regulation of juvenile hormone metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone.


negative regulation of reductive pentose-phosphate cycle

Any process that stops, prevents, or reduces the frequency, rate or extent of the reductive pentose-phosphate cycle.


regulation of protection from non-homologous end joining at telomere

Any process that modulates the frequency, rate or extent of protection from non-homologous end joining at telomere.


negative regulation of 3'-UTR-mediated mRNA stabilization

Any process that stops, prevents or reduces the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.


negative regulation of interleukin-3 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production.


positive regulation of isoprene metabolic process

Any process that activates or increases the frequency, rate or extent of isoprene metabolic process.


negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.


positive regulation of methane biosynthetic process from dimethyl sulfide

Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide.


negative regulation of transforming growth factor beta3 activation

Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta3 activation.


regulation of sinapate ester biosynthetic process

Any process that modulates the frequency, rate or extent of sinapate ester biosynthesis.


regulation of phosphate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.


regulation of mitotic DNA replication initiation

Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication.


negative regulation of melanization defense response

Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection.


positive regulation of interleukin-24 production

Any process that activates or increases the frequency, rate, or extent of interleukin-24 production.


positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process

Any process that activates or increases the frequency, rate or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process.


regulation of siRNA-independent facultative heterochromatin formation

Any process that modulates the frequency, rate or extent of siRNA-independent facultative heterochromatin assembly.


negative regulation of connective tissue growth factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production.


negative regulation of glycolytic fermentation to ethanol

Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to ethanol.


regulation of telomere maintenance in response to DNA damage

Any process that modulates the frequency, rate or extent of telomere maintenance in response to DNA damage.


negative regulation of mitochondrial ATP synthesis coupled electron transport

Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport.


epigenetic programming in the endosperm

The global programming of epigenetic modifications following binucleate central cell fertilization. This involves DNA methylation at the silent allele. In the endosperm, maternal genomes are hypomethylated compared with the paternal genome.


regulation of mitotic recombination-dependent replication fork processing

Any process that modulates the frequency, rate or extent of mitotic recombination-dependent replication fork processing. Regulation of mitotic recombination prevents recombination between inappropriate homologous sequences.


regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway

Any process that modulates the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway.


regulation of starch biosynthetic process

An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch.


regulation of transcription elongation by RNA polymerase I

Any process that modulates the frequency, rate or extent of transcription elongation from RNA polymerase I promoter.


regulation of sterigmatocystin biosynthetic process

Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.


negative regulation of inositol trisphosphate biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.


positive regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process

Any process that activates or increases the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process.


positive regulation of mitotic recombination

Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis.


positive regulation of telomerase RNA reverse transcriptase activity

Any process that activates or increases the frequency, rate or extent of telomerase RNA reverse transcriptase activity.


positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.


positive regulation of fumagillin biosynthetic process

Any process that activates or increases the frequency, rate or extent of fumagillin biosynthetic process.


regulation of proanthocyanidin biosynthetic process

Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process.


regulation of tRNA stability

Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs.


positive regulation of plant-type cell wall cellulose biosynthetic process

Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process.


positive regulation of autophagy in response to ER overload

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The process in which the accumulation of misfolded proteins in the endoplasmic reticulum triggers a response that positively regulates autophagy.


regulation of transcription initiation by RNA polymerase I

Any process that modulates the frequency, rate or extent of transcription initiation from RNA polymerase I promoter.


negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Any process that stops, prevents or reduces the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization.


regulation of telomerase RNA reverse transcriptase activity

Any process that modulates the frequency, rate or extent of telomerase RNA reverse transcriptase activity.


positive regulation of cobalamin metabolic process

Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process.


positive regulation of beta 2 integrin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.


positive regulation of natural killer cell cytokine production

Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production.


positive regulation of methane biosynthetic process from dimethylamine

Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethylamine.


regulation of mitochondrial gene expression

Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).


regulation of transcriptional start site selection at RNA polymerase II promoter

Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.


negative regulation of chemokine (C-C motif) ligand 6 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).


regulation of pericentric heterochromatin formation

Any process that modulates the frequency, rate or extent of heterochromatin formation at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin.


regulation of B cell cytokine production

Any process that modulates the frequency, rate, or extent of B cell cytokine production.


positive regulation of interleukin-9 production

Any process that activates or increases the frequency, rate, or extent of interleukin-9 production.


regulation of DNA strand elongation

Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand.


positive regulation of juvenile hormone biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone.


regulation of spermidine biosynthetic process

Any process that modulates the frequency, rate or extent of spermidine biosynthetic process.


regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


positive regulation of DNA strand elongation

Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand.


regulation of meiotic DNA double-strand break formation

Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation.


negative regulation of inositol phosphate biosynthetic process

Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.


negative regulation of transforming growth factor beta1 activation

Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta1 activation.


regulation of macrophage inflammatory protein-1 gamma production

Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma.


regulation of aflatoxin biosynthetic process

Any process that modulates the frequency, rate or extent of aflatoxin biosynthetic process.


negative regulation of juvenile hormone metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone.


regulation of beta 2 integrin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.


regulation of methane biosynthetic process from carbon monoxide

Any process that modulates the frequency, rate or extent of methane biosynthetic process from carbon monoxide.


regulation of phytol biosynthetic process

Any process that modulates the frequency, rate or extent of phytol biosynthetic process.


positive regulation of chemokine (C-C motif) ligand 4 production

Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4.


negative regulation of interleukin-32 production

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 production.


negative regulation of integrin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.


regulation of antifungal peptide production

Any process that modulates the frequency, rate, or extent of antifungal peptide production.


negative regulation of demethylkotanin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of demethylkotanin biosynthetic process.


positive regulation of interleukin-37 production

Any process that activates or increases the frequency, rate or extent of interleukin-37 production.


regulation of phosphatidylinositol dephosphorylation

Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol.


regulation of granzyme A production

Any process that modulates the frequency, rate or extent of granzyme A production.


positive regulation of methyl-branched fatty acid biosynthetic process

Any process that activates or increases the frequency, rate or extent of methyl-branched fatty acid biosynthetic process.


positive regulation of ethylene biosynthetic process

Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process.


negative regulation of granzyme B production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granzyme B.


positive regulation of NAD+ kinase activity

Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule.


negative regulation of oxygen metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process.


negative regulation of antifungal peptide secretion

Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion.


positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


dosage compensation by hypoactivation of X chromosome

Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans.


regulation of tRNA catabolic process

Any process that modulates the frequency, rate or extent of tRNA catabolic process.


positive regulation of B cell cytokine production

Any process that activates or increases the frequency, rate, or extent of B cell cytokine production.


positive regulation of protection from non-homologous end joining at telomere

Any process that activates or increases the frequency, rate or extent of protection from non-homologous end joining at telomere.


regulation of interleukin-20 production

Any process that modulates the frequency, rate, or extent of interleukin-20 production.


siRNA-independent facultative heterochromatin formation

The formation of facultative heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process independent of small interfering RNAs.


siRNA-mediated post-transcriptional gene silencing

A post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) elicit silencing of specific target genes. siRNAs are 21-23 nucleotide RNA duplexes that are fully complementary to their target mRNA. siRNAs can be exported and act in other cells, including in germline cells. Once incorporated into a RNA-induced silencing complex (RISC), siRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the mRNA or mRNA translational repression. siRNAs are present in lower animals and plants, but not found in mammals; whereas miRNAs are present in all the animals and in plants.


positive regulation of termination of RNA polymerase I transcription

Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase I transcription.


regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

Any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.


regulation of methane biosynthetic process from dimethylamine

Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethylamine.


positive regulation of DNA-directed DNA polymerase activity

Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity.


positive regulation of mitochondrial mRNA catabolic process

Any process that activates or increases the frequency, rate or extent of mitochondrial mRNA catabolic process.


regulation of histidine biosynthetic process

Any process that modulates the frequency, rate or extent of histidine biosynthetic process.


negative regulation of antimicrobial peptide production

Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production.


nitrogen catabolite regulation of transcription from RNA polymerase II promoter

A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.


regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Any process that modulates the frequency, rate or extent of a parkin-mediated process that positively regulates mitophagy in response to mitochondrial depolarization.


positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process

Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process.


positive regulation of glycine hydroxymethyltransferase activity

Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.


regulation of auxin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth.


positive regulation of electron transfer activity

Any process that activates or increases the frequency, rate or extent of electron transfer activity.


positive regulation of oxygen metabolic process

Any process that activates or increases the frequency, rate or extent of oxygen metabolic process.


positive regulation of endothelin production

Any process that activates or increases the frequency, rate or extent of endothelin production.


positive regulation of cellulose biosynthetic process

Any process that activates or increases the frequency, rate or extent of cellulose biosynthetic process.


regulation of initiation of premeiotic DNA replication

Any process that modulates the frequency, rate or extent of initiation of premeiotic DNA replication.


regulation of ascospore wall chitin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin.


positive regulation of DNA replication initiation

Any process that activates or increases the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication.


replication fork progression beyond termination site

Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks.


negative regulation of sterigmatocystin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of sterigmatocystin biosynthetic process.


regulation of isoprene metabolic process

Any process that modulates the frequency, rate or extent of isoprene metabolic process.


positive regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.


regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).


regulation of interleukin-16 production

Any process that modulates the frequency, rate, or extent of interleukin-16 production.


positive regulation of glucose catabolic process to lactate via pyruvate

Any process that activates or increases the frequency, rate or extent of glucose catabolic process to lactate via pyruvate.


induction by virus of catabolism of host mRNA

The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA).


positive regulation of DNA recombination at centromere

Any process that activates or increases the frequency, rate or extent of DNA recombination at the centromere.


regulation of exonucleolytic catabolism of deadenylated mRNA

Any process that modulates the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay.


negative regulation of interleukin-9 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production.


negative regulation of dCDP biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of dCDP biosynthetic process.


regulation of telomere maintenance via recombination

Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.


positive regulation of phosphatidylserine metabolic process

Any process that activates or increases the frequency, rate or extent of phosphatidylserine metabolic process.


regulation of type I site-specific deoxyribonuclease activity

Any process that modulates the frequency, rate or extent of a type I restriction endodeoxyribonuclease activity.


regulation of DNA recombination at centromere

Any process that modulates the frequency, rate or extent of DNA recombination within centromeric DNA.


regulation of termination of RNA polymerase I transcription

Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription.


regulation of orcinol biosynthetic process

Any process that modulates the frequency, rate or extent of orcinol biosynthetic process.


positive regulation of DNA demethylation

Any process that activates or increases the frequency, rate or extent of DNA demethylation.


positive regulation of tetrapyrrole catabolic process

Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process.


negative regulation of fumagillin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of fumagillin biosynthetic process.


positive regulation of macrophage inflammatory protein-1 gamma production

Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma.


negative regulation of granulocyte colony-stimulating factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor.


positive regulation of granzyme A production

Any process that activates or increases the frequency, rate or extent of granzyme A production.


regulation of natural killer cell cytokine production

Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production.


regulation of DNA ligase activity

Any process that modulates the frequency, rate or extent of DNA ligase activity.


random inactivation of X chromosome

Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex.


positive regulation of DNA-templated DNA replication initiation

Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication.


regulation of methane biosynthetic process from dimethyl sulfide

Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide.


gene silencing by RNA-directed DNA methylation

A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism.


regulation of transcription by RNA polymerase II

Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.


suppression by virus of host translation initiation

Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein.


regulation of telomeric loop formation

Any process that modulates the frequency, rate or extent of telomeric loop formation.


positive regulation of transcription from RNA polymerase II promoter by galactose

Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.


regulation of D-erythro-sphingosine kinase activity

Any process that modulates the frequency, rate or extent of D-erythro-sphingosine kinase activity.


negative regulation of interleukin-19 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production.


regulation of ergosterol biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.


regulation of fractalkine production

Any process that modulates the frequency, rate, or extent of fractalkine production.


epigenetic programing of male pronucleus

The global programming of epigenetic modifications in the male pronucleus of the newly fertilized zygote. The most major change in the paternal genome is DNA demethylation, which takes place before the first cell division.


regulation of base-excision repair

Any process that modulates the frequency, rate or extent of base-excision repair.


negative regulation of histidine biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of histidine biosynthetic process.


regulation of termination of DNA-templated transcription

Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.


regulation of type II site-specific deoxyribonuclease activity

Any process that modulates the frequency, rate or extent of a type II restriction endodeoxyribonuclease activity.


negative regulation of tumor necrosis factor (ligand) superfamily member 11 production

Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production.


positive regulation of telomere maintenance via recombination

Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.


suppression by virus of host cytokine production

Any viral process that results in the inhibition of host cell cytokine production.


positive regulation of macrophage inflammatory protein 1 alpha production

Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha.


regulation of interleukin-7 production

Any process that modulates the frequency, rate, or extent of interleukin-7 production.


regulation of mating-type specific transcription, DNA-templated

Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription.


positive regulation of methane biosynthetic process from methanethiol

Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methanethiol.


negative regulation of diorcinol biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of diorcinol biosynthetic process.


negative regulation of diacylglycerol biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol biosynthetic process.


regulation of cell wall (1->3)-alpha-glucan biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells.


positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source

A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.


positive regulation of mitochondrial ATP synthesis coupled electron transport

Any process that activates or increases the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport.


negative regulation of auxin metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth.


regulation of methane biosynthetic process from trimethylamine

Any process that modulates the frequency, rate or extent of methane biosynthetic process from trimethylamine.


piRNA-mediated retrotransposon silencing by mRNA destabilization

A retrotransposon silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation by a piRNA.


negative regulation of interleukin-25 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production.


regulation of transforming growth factor beta2 activation

Any process that modulates the frequency, rate or extent of transforming growth factor beta2 activation.


negative regulation of phosphatidate phosphatase activity

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidate phosphatase activity.


regulation of carbohydrate phosphatase activity

Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate.


regulation of cobalamin metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.


positive regulation of siRNA processing

Any process that activates or increases the frequency, rate or extent of siRNA processing.


positive regulation of NAD metabolic process

Any process that activates or increases the frequency, rate or extent of NAD metabolic process.


regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Any process that modulates the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity.


regulation of mitochondrial mRNA stability

Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs.


3' transitive RNA interference

An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA.


negative regulation of antimicrobial peptide secretion

Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion.


negative regulation of fractalkine production

Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production.


negative regulation of violaceol I biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of violaceol I biosynthetic process.


positive regulation of mRNA modification

Any process that increases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


negative regulation of TRAIL production

Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production.


regulation of glycolytic process through fructose-6-phosphate

Any process that modulates the frequency, rate or extent of glycolytic process through fructose-6-phosphate.


positive regulation of transforming growth factor beta1 activation

Any process that activates or increases the frequency, rate or extent of transforming growth factor beta1 activation.


negative regulation of interleukin-27 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production.


positive regulation of phosphatidylcholine metabolic process

Any process that activates or increases the frequency, rate or extent of phosphatidylcholine metabolic process.


positive regulation of telomeric loop formation

Any process that activates or increases the frequency, rate or extent of telomeric loop formation.


regulation of chlorophyll catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll.


regulation of mitochondrial rRNA stability

Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs.


subtelomeric heterochromatin formation

The compaction of chromatin into heterochromatin at the subtelomeric region.


regulation of (1->3)-alpha-glucan biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds.


positive regulation of spermidine biosynthetic process

Any process that activates or increases the frequency, rate or extent of spermidine biosynthetic process.


positive regulation of poly(A)-specific ribonuclease activity

Any process that activates or increases the frequency, rate or extent of poly(A)-specific ribonuclease activity.


regulation of mRNA stability involved in response to oxidative stress

A process of regulation of mRNA stability that is involved in a response to oxidative stress.


positive regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity.


regulation of primary miRNA processing

Any process that modulates the frequency, rate or extent of primary microRNA processing.


positive regulation of antifungal peptide production

Any process that activates or increases the frequency, rate, or extent of antifungal peptide production.


positive regulation of meiotic DNA double-strand break formation

Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation.


positive regulation of cytochrome-c oxidase activity

Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity.


positive regulation of exonucleolytic catabolism of deadenylated mRNA

Any process that activates or increases the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay.


negative regulation of plant-type cell wall cellulose biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process.


regulation of (1->6)-beta-D-glucan biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans.


positive regulation of double-strand break repair via homologous recombination

Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination.


positive regulation of IP-10 production

Any process that activates or increases the frequency, rate, or extent of production of IP-10.


regulation of silent mating-type cassette heterochromatin formation

Any process that modulates the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette.


negative regulation of thiamine diphosphate biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate.


negative regulation of juvenile hormone biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone.


positive regulation of interleukin-19 production

Any process that activates or increases the frequency, rate, or extent of interleukin-19 production.


negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway

Any process that stops, prevents or reduces the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway.


regulation of vitamin E biosynthetic process

Any process that modulates the frequency, rate or extent of vitamin E biosynthetic process.


negative regulation of antibacterial peptide secretion

Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion.


regulation of interleukin-19 production

Any process that modulates the frequency, rate, or extent of interleukin-19 production.


regulation of juvenile hormone catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone.


positive regulation of chemokine (C-X-C motif) ligand 9 production

Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9.


regulation of microlipophagy

Any process that modulates the frequency, rate or extent of microlipophagy, the microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion.


regulation of transcription from RNA polymerase II promoter by galactose

Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.


positive regulation of antifungal peptide secretion

Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion.


positive regulation of base-excision repair

Any process that activates or increases the frequency, rate or extent of base-excision repair.


negative regulation of thiamine biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine.


regulation of melanization defense response

Any process that affects the rate, extent or location of the melanization defense response during injury or invasion.


regulation of DNA-directed DNA polymerase activity

Any process that modulates the frequency, rate or extent of DNA-directed DNA polymerase activity.


regulation of auxin metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth.