asperfuranone metabolic process

The chemical reactions and pathways involving asperfuranone.


multiple mitochondrial dysfunctions syndrome 6

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inborn organic aciduria

An inherited disorder that affects the metabolism of any acidic compound containing carbon in a covalent linkage.


Neurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiency is characterized by delayed motor development, hypotonia and progressive neurodegeneration. To date, it has been described in four boys. The syndrome is caused by mutations affecting the two alleles of the HIBCH gene, encoding 3-hydroxyisobutyryl-CoA hydrolase. The mode of transmission has not yet been established.


3-hydroxyisobutyric aciduria

3 hydroxyisobutyric aciduria is characterized by ketoacidotic episodes, cerebral anomalies and facial dysmorphism. It is an organic aciduria that involves valine metabolism. Thirteen cases have been described in the literature so far. Transmission is thought to be autosomal recessive.


maple syrup urine disease

An autosomal recessive inherited disorder caused by mutations in the BCKDHA, BCKDHB, DBT, and DLD genes. It is characterized by a deficiency of branched-chain alpha-keto acid dehydrogenase complex, leading to accumulation of metabolites in the body fluids. The name of the disease derives from the sweet odor of the urine in infants, reminiscent of maple syrup. Signs and symptoms usually appear in infancy and include lethargy and developmental delays. If untreated, it may lead to seizures, coma, and death.


glutaric acidemia type 3

Glutaryl-CoA oxidase deficiency is a peroxisomal disorder leading to glutaric aciduria. The prevalence is unknown. There is no distinctive phenotype associated with this disorder and one of the reported cases was asymptomatic. Transmission appears to be autosomal recessive.


3-methylcrotonyl-CoA carboxylase deficiency (3-MCCD) is an inherited disorder of leucine metabolism characterized by a highly variable clinical picture ranging from metabolic crisis in infancy to asymptomatic adults.


3-methylglutaconic aciduria type 3

3-methylglutaconic aciduria type III (MGA III) is an organic aciduria characterized by the association of optic atrophy and choreoathetosis with 3-methylglutaconic aciduria.


beta-ketothiolase deficiency

Beta-ketothiolase (T2) deficiency is a rare organic aciduria affecting ketone body metabolism and the catabolism of isoleucine and characterized by intermittent ketoacidotic episodes associated with vomiting, dyspnea, tachypnoea, hypotonia, lethargy and coma, with an onset during infancy or toddlerhood and usually ceasing by adolescence.


3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome

Any 3-methylglutaconic aciduria in which the cause of the disease is a mutation in the SERAC1 gene.


methylmalonic aciduria, cblB type

An autosomal recessive form of methylmalonic aciduria, caused by mutation(s) in the MMAB gene, encoding cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial.


methylmalonate semialdehyde dehydrogenase deficiency


maple syrup urine disease type 1A

A maple syrup urine disease caused by mutations in BCKDHA.


methylmalonic acidemia due to methylmalonyl-CoA epimerase deficiency

Methylmalonic acidemia due to methylmalonyl-CoA epimerase deficiency is a rare inborn error of metabolism disease characterized by mild to moderate, persistent elevation of methylmalonic acid in plasma, urine and cerebrospinal fluid. Clinical presentation may include acute metabolic decompensation with metabolic acidosis (presenting with vomiting, dehydration, confusion, hallucinations), nonspecific neurological symptoms, or may also be asymptomatic.


thiamine-responsive maple syrup urine disease

Thiamine-responsive maple syrup urine disease (thiamine-responsive MSUD) is a less severe variant of MSUD that manifests with a phenotype similar to intermediate MSUD but that responds positively to treatment with thiamine.


inherited fatty acid metabolism disorder

A group of genetic disorders that result from the inability to produce or use an enzyme required to oxidize fatty acids, resulting in an inability to generate energy from fatty acid sources.


multiple carboxylase deficiency

Multiple carboxylase deficiency (MCD) is a term used to describe inborn errors of biotin metabolism characterized by reduced activities of biotin-dependent enzymes resulting in a wide spectrum of symptoms, including feeding difficulty, breathing difficulties, lethargy, seizures, skin rash, alopecia, and developmental delay.


fatal multiple mitochondrial dysfunctions syndrome

Multiple mitochondrial dysfunctions syndrome describes a group of rare inborn errors of energy metabolism due to defects in mitochondrial [4Fe-4S] protein assembly. Patients present with a neonatal/infancy onset of metabolic lactic acidosis (that may be associated with hyperglycinemia and other abnormal metabolic testing results), muscular hypotonia, absence of psychomotor development or developmental regression, as well as abnormal neuroimaging findings (including leukodystrophy, brain developmental defects, white matter abnormalities, cerebral atrophy), and other variable clinical features (e.g., optic atrophy, cardiomyopathy, pulmonary hypertension, seizures, and dysmorphic features). Early fatal outcome is usual.


malonic aciduria

Malonic aciduria is a metabolic disorder caused by deficiency of malonyl-CoA decarboxylase (MCD).


methylmalonic aciduria and homocystinuria

An inborn error of vitamin B12 (cobalamin) metabolism characterized by megaloblastic anemia, lethargy, failure to thrive, developmental delay, intellectual deficit and seizures. There are four complementation classes of cobalamin defects (cblC, cblD, cblF and cblJ) that are responsible for methylmalonic acidemia - homocystinuria (methylmalonic acidemia - homocystinuria cblC, cblD cblF and cblJ).


disorder of fatty acid oxidation and ketogenesis


inherited lipoic acid biosynthesis defect

An inherited metabolic disease that is has its basis in the disruption of lipoate biosynthetic process.


vitamin B12-unresponsive methylmalonic acidemia type mut0

Vitamin B12-unresponsive methylmalonic acidemia type mut0 is an inborn error of metabolism characterized by recurrent ketoacidotic comas or transient vomiting, dehydration, hypotonia and intellectual deficit, which does not respond to administration of vitamin B12.


isovaleric acidemia

Isovaleric acidemia (IVA) is an autosomal recessively inherited organic aciduria characterized by a deficiency in isovaleryl-CoA dehydrogenase, that has wide clinical variability and that can present in infancy with acute manifestations of vomiting, failure to thrive, seizures, lethargy, a characteristic ''sweaty feet'' odor, acute pancreatitis and mild to severe developmental delay or in childhood with metabolic acidosis (brought on by prolonged fasting, an increased intake of protein-rich food or infections) and that can be fatal if not treated immediately. Chronic intermittent presentations and asymptomatic patients have also been reported.


pyruvate dehydrogenase E3 deficiency

Pyruvate dehydrogenase E3 deficiency is a very rare subtype of pyruvate dehydrogenase deficiency (PDHD) characterized by either early-onset lactic acidosis and delayed development, later-onset neurological dysfunction or liver disease.


methylmalonic aciduria, cblA type

An autosomal recessive form of methylmalonic aciduria, caused by mutation(s) in the MMAA gene, encoding MMAA protein.


methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency

Vitamin B12-unresponsive methylmalonic acidemia is an inborn error of vitamin B12 (cobalamin) metabolism characterized by recurrent ketoacidotic crises or transient vomiting, dehydration, hypotonia and intellectual deficit, which does not respond to administration of vitamin B12. There are two types of vitamin B12-unresponsive methylmalonic acidemia: mut0 and mut-.


medium chain acyl-CoA dehydrogenase deficiency

Medium chain acyl-CoA dehydrogenase (MCAD) deficiency (MCADD) is an inborn error of mitochondrial fatty acid oxidation characterized by a rapidly progressive metabolic crisis, often presenting as hypoketotic hypoglycemia, lethargy, vomiting, seizures and coma, which can be fatal in the absence of emergency medical intervention.


combined malonic and methylmalonic acidemia

Combined malonic and methylmalonic acidemia is a rare inborn error of metabolism characterized by elevation of malonic acid (MA) and methylmalonic acid (MMA) in body fluids, with higher levels of MMA than MA. CMAMMA presents in childhood with metabolic acidosis, developmental delay, dystonia and failure to thrive or in adulthood with seizures, memory loss and cognitive decline.


methylmalonic acidemia with homocystinuria, type cblX


methylmalonic aciduria and homocystinuria type cblD

A form of methylmalonic acidemia with homocystinuria, an inborn error of vitamin B12 (cobalamin) metabolism characterized by variable biochemical, neurological and hematological manifestations.


Carnitine-acylcarnitine translocase (CACT) deficiency is a life-threatening, inherited disorder of fatty acid oxidation which usually presents in the neonatal period with severe hypoketotic hypoglycemia, hyperammonemia, cardiomyopathy and/or arrhythmia, hepatic dysfunction, skeletal muscle weakness, and encephalopathy.


3-methylglutaconic aciduria type 5

A syndrome characterized by severe early onset (before the age of three years) dilated cardiomyopathy (DCM) with conduction defects (long QT syndrome), non-progressive cerebellar ataxia, testicular dysgenesis, and 3-methylglutaconic aciduria.


maple syrup urine disease type 1B

A maple syrup urine disease caused by mutations in BCKDHB.


intermediate maple syrup urine disease

Intermediate maple syrup urine disease (intermediate MSUD) is a milder form of MSUD characterized by persistently raised branched-chain amino acids (BCAAs) and ketoacids, but fewer or no acute episodes of decompensation.


methylmalonic aciduria and homocystinuria type cblF

A form of methylmalonic acidemia with homocystinuria, an inborn error of vitamin B12 (cobalamin) metabolism characterized by megaloblastic anemia, lethargy, failure to thrive, developmental delay, intellectual deficit and seizures. The disorder is caused by mutations in the LMBRD1 gene (6q13) and is transmitted in an autosomal recessive manner.


methylmalonic aciduria and homocystinuria type cblC

A form of methylmalonic acidemia with homocystinuria, an inborn error of vitamin B12 (cobalamin) metabolism characterized by megaloblastic anemia, lethargy, failure to thrive, developmental delay, intellectual deficit and seizures. cblC type methylmalonic acidemia with homocystinuria is caused by mutations in the MMACHC gene (1p36.3) and is transmitted in an autosomal recessive manner.


systemic primary carnitine deficiency disease

Systemic primary carnitine deficiency (SPCD) is a potentially lethal disorder of fatty acid oxidation characterized classically by early childhood onset cardiomyopathy often with weakness and hypotonia, failure to thrive and recurrent hypoglycemic hypoketotic seizures and/or coma.


intermittent maple syrup urine disease

Intermittent maple syrup urine disease (intermittent MSUD) is a mild form of MSUD where patients (when well) are asymptomatic with normal levels of branched-chain amino acids (BCAAs) but with catabolic stress are at risk of acute decompensation with ketoacidosis, which can lead to cerebral edema and coma if untreated.


3-methylcrotonyl-CoA carboxylase 1 deficiency

Any 3-methylcrotonyl-CoA carboxylase deficiency in which the cause of the disease is a mutation in the MCCC1 gene.


3-methylglutaconic aciduria type 1

3-methylglutaconic aciduria (3-MGA) type I is an inborn error of leucine metabolism with a variable clinical phenotype ranging from mildly delayed speech to psychomotor retardation, coma, failure to thrive, metabolic acidosis and dystonia.


multiple mitochondrial dysfunctions syndrome 7


multiple mitochondrial dysfunctions syndrome 5


3-hydroxy-3-methylglutaryl-CoA synthase deficiency (HMG-CoA synthase deficiency) is a rare autosomal recessively inherited disorder of ketone body metabolism, reported in less than 20 patients to date, characterized clinically by episodes of decompensation (often associated with gastroenteritis or fasting) that present with vomiting, lethargy, hepatomegaly, non ketotic hypoglycemia and, in rare cases, coma. Patients are mostly asymptomatic between acute epidodes. HMG-CoA synthase deficiency requires an early diagnosis in order to avoid hypoglycemic crises that can lead to permanent brain damage or death.


3-methylglutaconic aciduria type 4

3-methylglutaconic aciduria (3-MGA) type IV, or unclassified 3-MGA, is a clinically heterogeneous disorder characterized by increased 3-methylglutaconic acid excretion in individuals that cannot be classified as having one of the other forms of 3-MGA (3-MGA I, II or III).


holocarboxylase synthetase deficiency

A life-threatening early-onset form of multiple carboxylase deficiency, an inborn error of biotin metabolism, that, if untreated, is characterized by vomiting, tachypnea, irritability, lethargy, exfoliative dermatitis, and seizures that can worsen to coma.


3-methylcrotonyl-CoA carboxylase 2 deficiency

Any 3-methylcrotonyl-CoA carboxylase deficiency in which the cause of the disease is a mutation in the MCCC2 gene.


transient neonatal multiple acyl-CoA dehydrogenase deficiency

Transient neonatal multiple acyl-CoA dehydrogenase deficiency describes a very rare condition where a maternal riboflavin deficiency causes an infant to present with manifestations similar to those seen in multiple acyl-CoA dehydrogenase (MAD) deficiency such as poor suck, metabolic acidosis and hypoglycemia, but that resolves completely with oral riboflavin. In the one patient described haploinsufficiency of the human riboflavin transporter (hRFT1) was described in the mother.


methylmalonic acidemia due to transcobalamin receptor defect

Methylmalonic aciduria due to transcobalamin receptor defect is a rare metabolite absorption and transport disorder characterized by a moderate increase of methylmalonic acid (MMA) in the blood and urine due to decreased cellular uptake of cobalamin resulting from decreased transcobalamin receptor function. Patients are usually asymptomatic however, screening reveals increased C3-acylcarnitine and MMA in plasma. Serum homocysteine levels may vary from normal to moderately elevated and retinal vascular occlusive disease, resulting in severe visual loss, has been reported.


lipoic acid synthetase deficiency

Lipoic acid synthetase deficiency is a rare condition that affects the mitochondria. Mitochondria are tiny structures found in almost every cell of the body. They are responsible for creating most of the energy necessary to sustain life and support growth. People affected by this condition generally experience early-onset lactic acidosis, severe encephalopathy, seizures, poor growth, hypotonia, and developmental delay. It is caused by changes (mutations) in the LIAS gene and it is inherited in an autosomal recessive pattern. Treatment is based on the signs and symptoms present in each person.


biotinidase deficiency

Biotinidase deficiency is a late-onset form of multiple carboxylase deficiency, an inborn error of biotin metabolism that, if untreated, is characterized by seizures, breathing difficulties, hypotonia, skin rash, alopecia, hearing loss and delayed development.


multiple mitochondrial dysfunctions syndrome 1

Any fatal multiple mitochondrial dysfunctions syndrome in which the cause of the disease is a mutation in the NFU1 gene.


multiple mitochondrial dysfunctions syndrome 2

Any fatal multiple mitochondrial dysfunctions syndrome in which the cause of the disease is a mutation in the BOLA3 gene.


multiple mitochondrial dysfunctions syndrome 4

Any fatal multiple mitochondrial dysfunctions syndrome in which the cause of the disease is a mutation in the ISCA2 gene.


classic maple syrup urine disease

Classic maple syrup urine disease (classic MSUD) is the most severe and probably common form of MSUD characterized by a maple syrup odor in the cerumen at birth, poor feeding, lethargy and focal dystonia, followed by progressive encephalopathy and central respiratory failure if untreated.


methylmalonic acidemia with homocystinuria, type cblJ

An autosomal recessive form of combined methylmalonic aciduria and homocystinuria, caused by mutation(s) in the ABCD4 gene, encoding lysosomal cobalamin transporter ABCD4.


glutaryl-CoA dehydrogenase deficiency

Glutaryl-CoA dehydrogenase (GCDH) deficiency (GDD) is an autosomal recessive neurometabolic disorder clinically characterized by encephalopathic crises resulting in striatal injury and a severe dystonic dyskinetic movement disorder.


multiple mitochondrial dysfunctions syndrome 3

Any fatal multiple mitochondrial dysfunctions syndrome in which the cause of the disease is a mutation in the IBA57 gene.


maple syrup urine disease type 2

A maple syrup urine disease caused by mutations in DBT.


short chain acyl-CoA dehydrogenase deficiency

Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is a very rare inborn error of mitochondrial fatty acid oxidation characterized by variable manifestations ranging from asymptomatic individuals (in most cases) to those with failure to thrive, hypotonia, seizures, developmental delay and progressive myopathy.


acyl-CoA dehydrogenase 9 deficiency

A rare disorder leading to a deficiency of complex I of the respiratory chain and is characterized by neurological dysfunction, hepatic failure and cardiomyopathy.


vitamin B12-unresponsive methylmalonic acidemia type mut-

Vitamin B12-unresponsive methylmalonic acidemia type mut- is an inborn error of metabolism characterized by recurrent ketoacidotic comas or transient vomiting, dehydration, hypotonia and intellectual deficit, which does not respond to administration of vitamin B12.


3-hydroxy-3-methylglutaric aciduria

3-hydroxy-3-methylglutaric aciduria (3HMG) is an organic aciduria, due to deficiency of 3-hydroxy-3-methylglutaryl-CoA-lyase (a key enzyme in ketogenesis and leucine metabolism) usually presenting in infancy with episodes of metabolic decompensation triggered by periods of fasting or infections, which when left untreated are life-threatening and may lead to neurological sequelae.


dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities


vitamin B12-responsive methylmalonic acidemia

Vitamin B12-responsive methylmalonic acidemia (MA) is an inborn error of vitamin B12 (cobalamin) metabolism characterized by recurrent ketoacidotic comas or transient vomiting, dehydration, hypotonia and intellectual deficit, which responds to vitamin B12. There are three types: cblA, cblB and cblD-variant 2 (cblDv2).


vitamin B12-responsive methylmalonic acidemia, type cblDv2


carnitine palmitoyl transferase 1A deficiency

Carnitine palmitoyltransferase 1A (CPT-1A) deficiency is an inborn error of metabolism that affects mitochondrial oxidation of long chain fatty acids (LCFA) in the liver and kidneys, and is characterized by recurrent attacks of fasting-induced hypoketotic hypoglycemia and risk of liver failure.


Hub1 activating enzyme activity

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Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond.


sulfopyruvate decarboxylase activity

Catalysis of the reaction: 3-sulfopyruvate + H+ = CO2 + sulfoacetaldehyde.


optic nerve formation

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The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.


Unresectable Pleural Sarcomatoid Mesothelioma

Pleural sarcomatoid mesothelioma that is not amenable to surgical resection.


Pleural Desmoplastic Mesothelioma

Malignant mesothelioma that arises from the pleura. It is characterized by the presence of dense collagenized stroma occupying at least 50% of the tumor. The malignant cells are arranged in a vague storiform pattern.


Unresectable Peritoneal Epithelioid Mesothelioma

Peritoneal epithelioid mesothelioma that is not amenable to surgical resection.


Unresectable Paratesticular Sarcomatoid Mesothelioma

Paratesticular sarcomatoid mesothelioma that is not amenable to surgical resection.


Paratesticular Epithelioid Mesothelioma

A rare malignant mesothelioma arising from the tunica vaginalis. It is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns.


Desmoplastic mesothelioma

A malignant neoplasm arising from mesothelial cells. It is characterized by the presence of a dense collagenous tissue and atypical neoplastic cells. Sarcomatoid features, collagenous necrosis, and infiltration of muscle and adipose tissue may be present. It occurs in the pleura and less commonly in the peritoneum.


Peritoneal Epithelioid Mesothelioma

Malignant mesothelioma that arises from the peritoneum. It is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns.


malignant biphasic mesothelioma

A malignant neoplasm arising from mesothelial cells in the pleura. It is characterized by the presence of neoplastic epithelioid cells and sarcomatoid features.


Unresectable Paratesticular Epithelioid Mesothelioma

Paratesticular epithelioid mesothelioma that is not amenable to surgical resection.


Peritoneal Biphasic Mesothelioma

Malignant mesothelioma that arises from the peritoneum. It is characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor.


Unresectable Pleural Biphasic Mesothelioma

Pleural biphasic mesothelioma that is not amenable to surgical resection.


Unresectable Paratesticular Biphasic Mesothelioma

Paratesticular biphasic mesothelioma that is not amenable to surgical resection.


Paratesticular Sarcomatoid Mesothelioma

A rare malignant mesothelioma arising from the tunica vaginalis. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen.


Unresectable Peritoneal Sarcomatoid Mesothelioma

Peritoneal sarcomatoid mesothelioma that is not amenable to surgical resection.


pleural biphasic mesothelioma

Malignant mesothelioma that arises from the pleura. It is characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor.


Advanced Epithelioid Mesothelioma

Epithelioid mesothelioma that has spread extensively to other anatomic sites or is no longer responding to treatment.


sarcomatoid mesothelioma

A diffuse malignant mesothelioma arising from the pleura and less often the peritoneum. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen.


pleural sarcomatoid mesothelioma

Malignant mesothelioma that arises from the pleura and is characterized by the presence of spindle-shaped cells forming fascicles, or that are distributed haphazardly resembling a sarcoma.


Paratesticular Biphasic Mesothelioma

A rare malignant mesothelioma arising from the tunica vaginalis. It is characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor.


Unresectable Pleural Epithelioid Mesothelioma

Pleural epithelioid mesothelioma that is not amenable to surgical resection.


Recurrent Epithelioid Mesothelioma

The reemergence of epithelioid mesothelioma after a period of remission.


pleural epithelioid mesothelioma

Malignant mesothelioma that arises from the pleura and is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns.


Unresectable Peritoneal Biphasic Mesothelioma

Peritoneal biphasic mesothelioma that is not amenable to surgical resection.


Peritoneal Sarcomatoid Mesothelioma

Malignant mesothelioma that arises from the peritoneum. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen.


malignant epithelioid mesothelioma

A malignant neoplasm arising from mesothelial cells in the pleura. It is characterized by the presence of neoplastic cells with an epithelioid appearance. In the majority of cases, the neoplastic epithelioid cells lack significant cytologic atypia; mitotic figures are infrequently seen. In a minority of cases, the neoplastic cells are poorly differentiated and there is evidence of nuclear atypia and increased mitotic activity.


antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen

Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR).


negative regulation of mast cell proliferation

Any process that stops, prevents or reduces the rate or extent of mast cell proliferation.


oculocutaneous albinism type 4

Oculocutaneous albinism type 4 (OCA4) is a type of OCA characterized by varying degrees of skin and hair hypopigmentation, numerous ocular changes and misrouting of the optic nerves at the chiasm.


embryonic heart tube dorsal/ventral pattern formation

The regionalization process in which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis.


lateral line nerve development

The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


posterior lateral line nerve development

The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


anterior lateral line nerve development

The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


spleen trabecula formation

The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod.


liver trabecula formation

The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod.


guanylate cyclase inhibitor activity

Binds to and stops, prevents or reduces the activity of guanylate cyclase.


molecular function regulator activity

A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.


acetylglutamate kinase regulator activity

Binds to and modulates the activity of acetylglutamate kinase.


channel activator activity

Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.


gonadotropin hormone-releasing hormone activity

The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary.


inositol phosphoceramide synthase regulator activity

Binds to and modulates the activity of inositol phosphoceramide synthase.


histone methyltransferase inhibitor activity

Binds to and stops, prevents or reduces the activity of a histone methyltransferase.


transmembrane receptor protein tyrosine kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase.


chemoattractant activity involved in axon guidance

Any chemoattractant activity that is involved in axon guidance.


RNA polymerase inhibitor activity

Binds to and stops, prevents or reduces the activity of RNA polymerase.


eclosion hormone activity

The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis.


pseudophosphatase activity

Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues.


cyclin-dependent protein kinase activating kinase activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).


phosphatidylinositol 3-kinase activator activity

Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K).


peroxidase inhibitor activity

Binds to and stops, prevents or reduces the activity of peroxidase.


urease activator activity

Increases the activity of urease by promoting the incorporation of nickel into the active site.


phosphatidylinositol 3-kinase inhibitor activity

Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K).


melanin-concentrating hormone activity

The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals.


digestive hormone activity

The action characteristic of a hormone that takes part in the digestion process.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


adenylate cyclase regulator activity

Binds to and modulates the activity of adenylate cyclase.


Binds to and increases the activity of an endodeoxyribonuclease.


tyrosine 3-monooxygenase activator activity

Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase).


mating pheromone activity

The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted.


tryptophan hydroxylase activator activity

Increases the activity of the enzyme tryptophase hydroxylase.


glutamate-cysteine ligase regulator activity

Binds to and modulates the activity of glutamate-cysteine ligase.


ligase inhibitor activity

Binds to and stops, prevents or reduces the activity of a ligase.


melanocyte-stimulating hormone activity

The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates.


aldehyde dehydrogenase (NAD+) inhibitor activity

Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+).


[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity

Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase.


myoinhibitory hormone activity

The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction.


phospholipase D activator activity

Binds to and increases the activity of the enzyme phospholipase D.


polynucleotide adenylyltransferase activator activity

Increases the activity of the enzyme polynucleotide adenylyltransferase.


acetylcholine receptor inhibitor activity

Binds to and stops, prevents or reduces the activity of an acetylcholine receptor.


phospholipase D inhibitor activity

Binds to and stops, prevents or reduces the activity of phospholipase D.


receptor signaling protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.


prothoracicotrophic hormone activity

The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects.


follicle-stimulating hormone activity

The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis.


methionine adenosyltransferase regulator activity

Binds to and modulates the activity of methionine adenosyltransferase.


cyclin-dependent protein kinase activating kinase regulator activity

Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase.


deubiquitinase activator activity

Binds to and increases the activity of a deubiquitinase.


pituitary adenylate cyclase activating polypeptide activity

The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation.


adenylate cyclase inhibitor activity

Binds to and decreases the activity of adenylate cyclase.


cysteine-type endopeptidase activator activity

Binds to and increases the activity of a cysteine-type endopeptidase.


ubiquitin ligase activator activity

Binds to and increases the activity of a ubiquitin ligase.


guanyl nucleotide exchange factor inhibitor activity

Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor.


competence pheromone activity

A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence.


death receptor agonist activity

Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor.


DNA strand exchange activator activity

Binds to and increases a DNA strand exchange activity.


miRNA inhibitor activity via base-pairing

Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs).


L-dopa decarboxylase activator activity

Interacts with and increases L-dopa decarboxylase activity.


Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity.


growth hormone activity

The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth.


ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity

Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate.


UTP:glucose-1-phosphate uridylyltransferase regulator activity

Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase.


molecular function activator activity

A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target.


receptor signaling protein tyrosine kinase activator activity

Binds to and increases the activity of a receptor signaling protein tyrosine kinase.


pathogen-derived receptor ligand activity

The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity.


cyclic nucleotide phosphodiesterase activator activity

Binds to and increases the activity of cyclic nucleotide phosphodiesterase.


cyclin-dependent protein serine/threonine kinase activator activity

Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.


acetylcholine receptor activator activity

Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.


endoribonuclease inhibitor activity

Binds to and stops, prevents or reduces the activity of endoribonuclease.


RNA helicase inhibitor activity

Binds to and stops, prevents or reduces the activity of an RNA helicase.


potassium channel activator activity involved in G protein-coupled receptor signaling pathway

Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling.


ornithine carbamoyltransferase inhibitor activity

Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase.


pectinesterase inhibitor activity

Binds to and stops, prevents or reduces the activity of pectinesterase.


eukaryotic elongation factor-2 kinase regulator activity

Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase.


ion channel regulator activity

Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.


myosin phosphatase regulator activity

Binds to and modulates of the activity of myosin phosphatase.


exoribonuclease activator activity

Binds to and increases the activity of an exoribonuclease.


ecdysis-triggering hormone activity

The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system.


GTP cyclohydrolase I regulator activity

Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.


mRNA phosphatase activator activity

Binds to and increases the activity of mRNA phosphatase.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity

Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity

Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase.


interleukin-1 type II receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 type II receptors.


peptidyl-dipeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain.


nitric-oxide synthase inhibitor activity

Binds to and stops, prevents or reduces the activity of nitric oxide synthase.


interleukin-1 type I receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 type I receptors.


small conductance calcium-activated potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel.


RNA lariat debranching enzyme activator activity

Binds to and increases the activity of an RNA lariat debranching enzyme.


1-phosphatidylinositol 4-kinase activator activity

Binds to and increases the activity of 1-phosphatidylinositol 4-kinase.


tRNA ligase activator activity

Binds to and increases the activity of a tRNA ligase.


acetolactate synthase regulator activity

Binds to and modulates the activity of acetolactate synthase.


calcium-dependent cysteine-type endopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner.


eukaryotic elongation factor-2 kinase activator activity

Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase.


activin receptor antagonist activity

Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.


sphingolipid activator protein activity

Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.


outward rectifier potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel.


dolichol-phosphate-mannose synthase regulator activity

Binds to and modulates the activity of dolichol-phosphate-mannose synthase.


ion channel regulator activity involved in G protein-coupled receptor signaling pathway

Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling.


nuclease inhibitor activity

Binds to and modulates the activity of a nuclease.


polygalacturonase inhibitor activity

Binds to and stops, prevents or reduces the activity of polygalacturonase.


pheromone activity

The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant.


ribonucleoside-diphosphate reductase inhibitor activity

Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase.


recombinase activator activity

Binds to and increases the activity of a recombinase.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity

Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


inward rectifier potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.


chemokine receptor antagonist activity

Interacts with chemokine receptors to reduce the action of a chemokine.


thyrotropin-releasing hormone activity

The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


SUMO ligase regulator activity

Binds to and modulates the activity of a SUMO ligase.


fibroblast growth factor receptor antagonist activity

Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.


The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.


guiding stereospecific synthesis activity

The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis.


DNA strand exchange inhibitor activity

Binds to and stops, prevents or reduces a DNA strand exchange activity.


alpha-amylase inhibitor activity

Binds to and stops, prevents or reduces the activity of alpha-amylase.


myostimulatory hormone activity

The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction.


cyclase inhibitor activity

Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction.


G protein activity

A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).


ubiquitin ligase inhibitor activity

Binds to and stops, prevents or reduces the activity of a ubiquitin ligase.


ecdysiostatic hormone activity

The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion.


adenylate cyclase activator activity

Binds to and increases the activity of adenylate cyclase.


molecular function inhibitor activity

A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target.


diuretic hormone activity

The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion.


neuropeptide activity

The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron.


lysozyme inhibitor activity

Binds to and stops, prevents or reduces the activity of lysozyme.


deoxyribonuclease inhibitor activity

Binds to and stops, prevents or reduces the activity of deoxyribonuclease.


guanyl-nucleotide exchange factor adaptor activity

The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.


dUTP pyrophosphatase inhibitor activity

Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase.


potassium channel activator activity

Binds to and increases the activity of a potassium channel, resulting in its opening.


Metastatic Squamous Cell Carcinoma of the Penis

Squamous cell carcinoma of the penis that has spread from its original site of growth to another anatomic site.


Nuclear Expression of STAT6 Protein

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

A finding indicating the presence of STAT6 nuclear signal in tumor cells by immunohistochemistry. It results from the fusion of the NAB2 and STAT6 genes.


2-butanone oxidase activity

Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate.


negative regulation of photomorphogenesis

Any process that stops, reduces or prevents photomorphogenesis.


Childhood Protoplasmic Astrocytoma

A protoplasmic astrocytoma that occurs during childhood.


Recurrent Childhood Protoplasmic Astrocytoma

The reemergence of protoplasmic astrocytoma in childhood after a period of remission.


Malignant fibrous histiocytoma recurrent

Reemergence of undifferentiated pleomorphic sarcoma after a period of remission.


Elevated HMGA2

A finding indicating elevated concentrations of HMGA2 in a sample.


positive regulation of brain-derived neurotrophic factor-activated receptor activity

Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


positive regulation of protein-pyridoxal-5-phosphate linkage

Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


positive regulation of kinin cascade

Any process that activates or increases the frequency, rate, or extent of the kinin cascade.


positive regulation of cap-dependent translational initiation

Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation.


regulation of hepatocyte growth factor production

Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production.


positive regulation of CD86 production

Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process.


regulation of translation at synapse

Any process that regulates translation occurring at the synapse.


regulation of protein phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.


regulation of glucosylceramide catabolic process

Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process.


positive regulation of proteolysis associated with antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.


regulation of CD24 production

Any process that modulates the frequency, rate or extent of CD24 biosynthetic process.


positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division

Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division.


negative regulation of hepatocyte growth factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production.


regulation of gliotoxin biosynthetic process

Any process that modulates the frequency, rate or extent of gliotoxin biosynthetic process.


positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.


positive regulation of aspartic-type peptidase activity

Any process that activates or increases the frequency, rate or extent of aspartic-type peptidase activity.


negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.


positive regulation of myosin light chain kinase activity

Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.


positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity

Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate.


positive regulation of tubulin deacetylation

Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.


positive regulation of protein histidine kinase activity

Any process that increases the frequency, rate or extent of protein histidine kinase activity.


regulation of lysosomal protein catabolic process

Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.


negative regulation of formation of translation initiation ternary complex

Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex.


positive regulation of translation in response to oxidative stress

Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


regulation of glucosylceramide biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


regulation of protein histidine kinase activity

Any process that modulates the frequency, rate or extent of protein histidine kinase activity.


negative regulation of inhibitory G protein-coupled receptor phosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.


regulation of amyloid fibril formation

Any process that modulates the frequency, rate or extent of amyloid fibril formation.


negative regulation of ferricrocin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of ferricrocin biosynthetic process.


regulation of protein modification process

Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


regulation of sphingomyelin catabolic process

Any process that modulates the frequency, rate or extent of sphingomyelin catabolic process.


positive regulation of translational frameshifting

Any process that activates or increases the frequency, rate or extent of translational frameshifting.


negative regulation of proteolysis associated with antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.


regulation of PSII associated light-harvesting complex II catabolic process

Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II.


negative regulation of protein processing in phagocytic vesicle

Any process that stops, prevents or reduces the frequency, rate or extent of protein processing in phagocytic vesicle.


positive regulation of tissue kallikrein-kinin cascade

Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade.


positive regulation of protein K63-linked deubiquitination

Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination.


regulation of elastin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.


positive regulation of selenocysteine incorporation

Any process that activates or increases the frequency, rate or extent of selenocysteine incorporation.


regulation of N-terminal peptidyl-lysine acetylation

Any process that modulates the frequency, rate or extent of N-terminal peptidyl-lysine acetylation.


regulation of translational initiation in response to osmotic stress

Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


negative regulation of protein K48-linked ubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


positive regulation of protein O-linked glycosylation

Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation.


positive regulation of ubiquitin-specific protease activity

Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity.


siRNA-mediated gene silencing by inhibition of translation

An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs.


regulation of translation involved in cellular response to UV

Any regulation of translation that is involved in cellular response to UV.


negative regulation of gliotoxin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of gliotoxin biosynthetic process.


positive regulation of peptidyl-L-cysteine S-palmitoylation

Any process that activates or increases the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation.


negative regulation of antimicrobial peptide biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis.


regulation of mitochondrial translational initiation

Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


regulation of Rho-dependent protein serine/threonine kinase activity

Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity.


negative regulation of blood coagulation, common pathway

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway.


regulation of CD80 production

Any process that modulates the frequency, rate or extent of CD80 biosynthetic process.


regulation of blood coagulation, intrinsic pathway

Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway.


negative regulation of mitochondrial translation

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


positive regulation of amide catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.


negative regulation of translation initiation in response to endoplasmic reticulum stress

Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.


regulation of urea catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea.


regulation of ferricrocin biosynthetic process

Any process that modulates the frequency, rate or extent of ferricrocin biosynthetic process.


negative regulation of protein neddylation

Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation.


regulation of glutathione biosynthetic process

Any process that modulates the frequency, rate or extent of glutathione biosynthetic process.


negative regulation of peptidyl-L-cysteine S-palmitoylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation.


negative regulation of peptidyl-serine phosphorylation of STAT protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


negative regulation of protein glutathionylation

Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.


positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.


sucrose induced translational repression

Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level.


negative regulation of protein desumoylation

Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.


negative regulation of I-kappaB phosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation.


regulation of protein adenylylation

Any process that modulates the frequency, rate or extent of protein adenylylation.


negative regulation of protein lipidation

Any process that stops, prevents or reduces the frequency, rate or extent of protein lipidation.


regulation of protein desumoylation

Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.


positive regulation of amyloid fibril formation

Any process that activates or increases the frequency, rate or extent of amyloid fibril formation.


positive regulation of translational fidelity

Any process that increases the ability of the translational apparatus to interpret the genetic code.


tRNA demethylation

The removal of a methyl group from one or more residues within a tRNA molecule.


positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation

Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation.


negative regulation of non-membrane spanning protein tyrosine kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.


negative regulation of brain-derived neurotrophic factor-activated receptor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


negative regulation of protein autoubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination.


negative regulation of CD80 production

Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process.


positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process.


positive regulation of Toll receptor ligand protein activation cascade

Any process that activates or increases the frequency, rate or extent of Toll receptor ligand protein activation cascade.


regulation of cytoplasmic translational fidelity

Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code.


negative regulation of protein tyrosine phosphatase activity

Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity.


negative regulation of emericellamide biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide biosynthetic process.


negative regulation of translational frameshifting

Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting.


regulation of emericellamide A biosynthetic process

Any process that modulates the frequency, rate or extent of emericellamide A biosynthetic process.


positive regulation of peptide hormone processing

Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone.


regulation of N-terminal peptidyl-methionine acetylation

Any process that modulates the frequency, rate or extent of N-terminal peptidyl-methionine acetylation.


negative regulation of kinin cascade

Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade.


negative regulation of plasma kallikrein-kinin cascade

Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade.


positive regulation of CD24 production

Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process.


regulation of lymphotoxin A production

Any process that modulates the frequency, rate, or extent of lymphotoxin A production.


positive regulation of elastin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.


negative regulation of amyloid fibril formation

Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.


negative regulation of glucosylceramide biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.


regulation of peptidyl-L-cysteine S-palmitoylation

Any process that modulates the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation.


negative regulation of protein geranylgeranylation

Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation.


positive regulation of blood coagulation, intrinsic pathway

Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway.


positive regulation of protein polyglycylation

Any process that activates or increases the frequency, rate or extent of protein polyglycylation.


positive regulation of mitochondrial translation in response to stress

Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress.


positive regulation of translation, ncRNA-mediated

Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein.


regulation of SUMO transferase activity

Any process that modulates the frequency, rate or extent of SUMO ligase activity.


regulation of N-terminal protein palmitoylation

Any process that modulates the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein.


regulation of proteolysis associated with antigen processing and presentation

Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.


regulation of amide catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.


regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

Any process that modulates the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation.


positive regulation of protein geranylgeranylation

Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation.


negative regulation of antibacterial peptide biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis.


negative regulation of elastin catabolic process

Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.


regulation of translation at presynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.


negative regulation of emericellamide A biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide A biosynthetic process.


negative regulation of cap-independent translational initiation

Any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation.


regulation of ferrichrome biosynthetic process

Any process that modulates the frequency, rate or extent of ferrichrome biosynthetic process.


regulation of oskar mRNA translation

Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex.


negative regulation of hemoglobin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


negative regulation of translational termination

Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.


positive regulation of glutathione biosynthetic process

Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process.


regulation of protein K63-linked deubiquitination

Any process that modulates the frequency, rate or extent of protein K63-linked deubiquitination.


regulation of pseurotin A biosynthetic process

Any process that modulates the frequency, rate or extent of pseurotin A biosynthetic process.


regulation of brain-derived neurotrophic factor-activated receptor activity

Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


regulation of eIF2 alpha phosphorylation by dsRNA

Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA.


negative regulation of lipoprotein lipid oxidation

Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group.


regulation of cap-dependent translational initiation

Any process that modulates the frequency, rate or extent of cap-dependent translational initiation.


regulation of translation at postsynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.


negative regulation of pentose-phosphate shunt

Any process that stops, prevents or reduces the frequency, rate or extent of pentose-phosphate shunt.


positive regulation of sphingomyelin catabolic process

Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process.


regulation of protein neddylation

Any process that modulates the frequency, rate or extent of protein neddylation.


regulation of protein K48-linked ubiquitination

Any process that modulates the rate, frequency or extent of protein K-48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


regulation of elastin catabolic process

Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.


regulation of formation of translation preinitiation complex

Any process that modulates the frequency, rate or extent of formation of translation preinitiation complex.


negative regulation of metallopeptidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity.


positive regulation of Lys63-specific deubiquitinase activity

Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity.


positive regulation of anaphase-promoting complex-dependent catabolic process

Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


regulation of blood coagulation, extrinsic pathway

Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway.


negative regulation of FasL production

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.


positive regulation of CD80 production

Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process.


negative regulation of myosin light chain kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity.


positive regulation of lymphotoxin A production

Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production.


negative regulation of glutathione biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of glutathione biosynthetic process.


positive regulation of translational initiation in response to osmotic stress

Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


regulation of mitochondrial translational elongation

Any process that modulates the frequency, rate or extent of mitochondrial translational elongation.


positive regulation of urea catabolic process

Any process that activates or increases the frequency, rate or extent of urea catabolic process.


negative regulation of protein linear polyubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein linear polyubiquitination.


negative regulation of Toll receptor ligand protein activation cascade

Any process that stops, prevents or reduces the frequency, rate or extent of Toll receptor ligand protein activation cascade.


negative regulation of peptide hormone processing

Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone.


regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.


regulation of cytoplasmic translational initiation in response to stress

Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


positive regulation of N-terminal peptidyl-methionine acetylation

Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-methionine acetylation.


regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Any process that modualtes the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


regulation of myosin light chain kinase activity

Any process that modulates the frequency, rate or extent of myosin light chain kinase activity.


negative regulation of ceramide biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.


negative regulation of protein catabolic process in the vacuole

Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole.


negative regulation of cytoplasmic translational initiation

Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation.


positive regulation of formation of translation preinitiation complex

Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex.


positive regulation of N-terminal peptidyl-serine acetylation

Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-serine acetylation.


negative regulation of cap-dependent translational initiation

Any process that stops, prevents or reduces the frequency, rate or extent of cap-dependent translational initiation.


negative regulation of protein histidine kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity.


negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.


negative regulation of tubulin deacetylase activity

Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylase activity.


regulation of antifungal peptide biosynthetic process

Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis.


positive regulation of SUMO transferase activity

Any process that activates or increases the frequency, rate or extent of SUMO transferase activity.


negative regulation of translational initiation in response to starvation

Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment.


regulation of metallopeptidase activity

Any process that modulates the frequency, rate or extent of metallopeptidase activity.


regulation of protein geranylgeranylation

Any process that modulates the frequency, rate or extent of protein geranylgeranylation.


viral translational readthrough

The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons.


regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.


regulation of siderophore biosynthetic process

Any process that modulates the frequency, rate or extent of siderophore biosynthetic process.


regulation of protein catabolic process at postsynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.


regulation of protein glutathionylation

Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.


positive regulation of myosin-light-chain-phosphatase activity

Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity.


negative regulation of oskar mRNA translation

Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein.


positive regulation of glucosylceramide biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


negative regulation of SUMO transferase activity

Any process that stops, prevents or reduces the frequency, rate or extent of SUMO ligase activity.


regulation of protein deneddylation

Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein.


positive regulation of cytoplasmic translational elongation

Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation.


negative regulation of protein oxidation

Any process that stops, prevents or reduces the frequency, rate or extent of protein oxidation.


positive regulation of oskar mRNA translation

Any process that activates or increases the frequency, rate or extent of oskar mRNA translation.


pyrrolysine incorporation

The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases.


positive regulation of pentose-phosphate shunt

Any process that activates or increases the frequency, rate or extent of pentose-phosphate shunt.


positive regulation of blood coagulation, extrinsic pathway

Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway.


regulation of actin phosphorylation

Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.


eIF2alpha dephosphorylation in response to endoplasmic reticulum stress

The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.


negative regulation of translation in response to oxidative stress

Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


negative regulation of anaphase-promoting complex-dependent catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


positive regulation of protein serine/threonine phosphatase activity

Any process that activates or increases the frequency, rate or extent of protein serine/threonine phosphatase activity.


negative regulation of translational initiation by iron

Any process involving iron that stops, prevents or reduces the rate of translational initiation.


negative regulation of mitochondrial translational initiation

Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


negative regulation of amide catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.


negative regulation of siderophore biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of siderophore biosynthetic process.


positive regulation of N-terminal peptidyl-lysine acetylation

Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation.


regulation of translation by machinery localization

Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.


positive regulation of protein tyrosine phosphatase activity

Any process that activates or increases the frequency, rate or extent of protein tyrosine phosphatase activity.


regulation of cytoplasmic translation in response to stress

Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


regulation of aspartic-type peptidase activity

Any process that modulates the frequency, rate or extent of aspartic-type peptidase activity.


positive regulation of lysosomal protein catabolic process

Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.


regulation of protein serine/threonine phosphatase activity

Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.


regulation of translation at postsynapse

Any process that regulates translation occurring at the postsynapse.


positive regulation of inhibitory G protein-coupled receptor phosphorylation

Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.


regulation of translation involved in anterior/posterior axis specification

Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis.


negative regulation of elastin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.


regulation of protein-pyridoxal-5-phosphate linkage

Any process that modulates the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


positive regulation of post-translational protein modification

Any process that activates or increases the frequency, rate or extent of post-translational protein modification.


positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation.


negative regulation of tubulin deacetylation

Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.


negative regulation of formation of translation preinitiation complex

Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex.


negative regulation of antifungal peptide biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis.


positive regulation of blood coagulation, common pathway

Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway.


positive regulation of pseurotin A biosynthetic process

Any process that activates or increases the frequency, rate or extent of pseurotin A biosynthetic process.


negative regulation of protein polyglycylation

Any process that stops, prevents or reduces the frequency, rate or extent of protein polyglycylation.


regulation of non-membrane spanning protein tyrosine kinase activity

Any process that modulates the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.


positive regulation of mitochondrial translational elongation

Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation.


negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


regulation of translation at presynapse

Any process that regulates translation occurring at the presynapse.


negative regulation of protein-pyridoxal-5-phosphate linkage

Any process that stops, prevents or reduces the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


positive regulation of translation initiation in response to endoplasmic reticulum stress

Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.


positive regulation of protein adenylylation

Any process that activates or increases the frequency, rate or extent of protein adenylylation.


positive regulation of plasma kallikrein-kinin cascade

Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade.


negative regulation of N-terminal peptidyl-methionine acetylation

Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-methionine acetylation.


regulation of translation in response to oxidative stress

Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


negative regulation of pseurotin A biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of pseurotin A biosynthetic process.


regulation of kinin cascade

Any process that modulates the frequency, rate, or extent of the kinin cascade.


positive regulation of glucosylceramide catabolic process

Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process.


negative regulation of protein adenylylation

Any process that stops, prevents or reduces the frequency, rate or extent of protein adenylylation.


regulation of emericellamide biosynthetic process

Any process that modulates the frequency, rate or extent of emericellamide biosynthetic process.


negative regulation of translational initiation in response to osmotic stress

Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


regulation of protein tyrosine phosphatase activity

Any process that modulates the frequency, rate or extent of protein tyrosine phosphatase activity.


positive regulation of hepatocyte growth factor production

Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production.


negative regulation of Rho-dependent protein serine/threonine kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity.


positive regulation of antifungal peptide biosynthetic process

Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis.


regulation of inhibitory G protein-coupled receptor phosphorylation

Any process that modulates the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.


regulation of selenocysteine incorporation

Any process that modulates the frequency, rate or extent of selenocysteine incorporation.


negative regulation of granulocyte macrophage colony-stimulating factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


positive regulation of elastin catabolic process

Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.


positive regulation of non-membrane spanning protein tyrosine kinase activity

Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.


positive regulation of metallopeptidase activity

Any process that activates or increases the frequency, rate or extent of metallopeptidase activity.


positive regulation of FasL production

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.


regulation of cytoplasmic translational termination

Any process that modulates the frequency, rate or extent of cytoplasmic translational termination.


negative regulation of ferrichrome biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of ferrichrome biosynthetic process.


negative regulation of cytoplasmic translational initiation in response to stress

Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.


negative regulation of ferrichrome biosynthetic process in response to iron

Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus.


negative regulation of protein metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.


negative regulation of protein K63-linked deubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked deubiquitination.


regulation of peptidyl-lysine crotonylation

Any process that modulates the frequency, rate or extent of crotonylation of a lysine residue in a protein.


regulation of tissue kallikrein-kinin cascade

Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade.


regulation of FasL production

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.


regulation of protein catabolic process at presynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.


negative regulation of tissue kallikrein-kinin cascade

Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade.


regulation of protein polyglycylation

Any process that modulates the frequency, rate or extent of protein polyglycylation.


positive regulation of tubulin deacetylase activity

Any process that activates or increases the frequency, rate or extent of tubulin deacetylase activity.