glyoxalase III activity

Catalysis of the reaction: methylglyoxal + H2O = D-lactate.


RAB42_HUMAN Ras-related protein Rab-42 (sprot)

A Ras-related protein Rab-42 that is encoded in the genome of human.


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The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.


oocyte axis specification

The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.


HDGL1_HUMAN Hepatoma-derived growth factor-like protein 1 (sprot)

A hepatoma-derived growth factor-like protein 1 that is encoded in the genome of human.


endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.


tyrosine biosynthetic process

The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.


uracil binding

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Binding to uracil.


microtubule nucleation by interphase microtubule organizing center

The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation.


Gtr1-Gtr2 GTPase complex

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A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins.


Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.


adenine/guanine mispair binding

Binding to a double-stranded DNA region containing an A/G mispair.


immunoglobulin production involved in immunoglobulin-mediated immune response

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.


phosphatidylinositol 3-kinase complex, class III, type I

A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.


SAM10_HUMAN Sterile alpha motif domain-containing protein 10 (sprot)

A sterile alpha motif domain-containing protein 10 that is encoded in the genome of human.


synapse assembly involved in innervation

The assembly of a synapse within a target tissue in which a nerve is invading.


positive regulation of mitotic recombination

Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis.


regulation of microtubule depolymerization

Any process that modulates the frequency, rate or extent of microtubule depolymerization.


KANK3_HUMAN KN motif and ankyrin repeat domain-containing protein 3 (sprot)

A KN motif and ankyrin repeat domain-containing protein 3 that is encoded in the genome of human.


propionate metabolic process, methylmalonyl pathway

The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway.


SWT1_HUMAN Transcriptional protein SWT1 (sprot)

A transcriptional protein SWT1 that is encoded in the genome of human.


sarcosine metabolic process

The chemical reactions and pathways involving sarcosine.


GOG8F_HUMAN Putative golgin subfamily A member 8F/8G (sprot)


A0A075B7D4_HUMAN Immunoglobulin kappa variable 1/OR2-108 (non-functional) (Fragment) (trembl)


Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine.


vacuole fusion, non-autophagic

The fusion of two vacuole membranes to form a single vacuole.


saccharopine dehydrogenase activity

Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor.


UBA1L_HUMAN Ubiquitin-associated protein 1-like (sprot)

A ubiquitin-associated protein 1-like that is encoded in the genome of human.


KI2LA_HUMAN Killer cell immunoglobulin-like receptor 2DL5A (sprot)

A killer cell immunoglobulin-like receptor 2DL5A that is encoded in the genome of human.


C163B_HUMAN Scavenger receptor cysteine-rich type 1 protein M160 (sprot)

A scavenger receptor cysteine-rich type 1 protein M160 that is encoded in the genome of human.


regulation of Rho guanyl-nucleotide exchange factor activity

Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.


nucleotide-excision repair, DNA damage recognition

The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix.


prolactin-releasing peptide receptor binding

Binding to a prolactin-releasing peptide receptor.


LBHD1_HUMAN LBH domain-containing protein 1 (sprot)

A protein that is a translation product of the LBHD1 gene in human.


TM14E_HUMAN Transmembrane protein 14EP (sprot)

A transmembrane protein 14EP that is encoded in the genome of human.


Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate.


lytic vacuole

A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.


STPG3_HUMAN Protein STPG3 (sprot)

A protein STPG3 that is encoded in the genome of human.


SPD8_HUMAN Putative speedy protein E8 (sprot)


maturation of 5S rRNA

Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule.


SPDE5_HUMAN Speedy protein E5 (sprot)

A protein that is a translation product of the SPDYE5 gene in human.


N-terminal peptidyl-alanine methylation

The methylation of the N-terminal alanine of proteins.


adenine salvage

Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis.


regulation of guanylate cyclase activity

Any process that modulates the frequency, rate or extent of guanylate cyclase activity.


LRC30_HUMAN Leucine-rich repeat-containing protein 30 (sprot)

A leucine-rich repeat-containing protein 30 that is encoded in the genome of human.


Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA.


WFD11_HUMAN Protein WFDC11 (sprot)

A protein WFDC11 that is encoded in the genome of human.


taste receptor binding

Binding to a taste receptor.


Intermediate conductance calcium-activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

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An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation.


amidophosphoribosyltransferase activity

Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O.


leukotriene B4 receptor activity

Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.


CLUL1_HUMAN Clusterin-like protein 1 (sprot)

A clusterin-like protein 1 that is encoded in the genome of human.


SPD13_HUMAN Putative speedy protein E13 (sprot)


thyrotropin-releasing hormone activity

The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O.


farnesyl diphosphate biosynthetic process, mevalonate pathway

The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols.


GRIN3_HUMAN G protein-regulated inducer of neurite outgrowth 3 (sprot)

A G protein-regulated inducer of neurite outgrowth 3 that is encoded in the genome of human.


MAGB1_HUMAN Melanoma-associated antigen B1 (sprot)

A melanoma-associated antigen B1 that is encoded in the genome of human.


AN34C_HUMAN Ankyrin repeat domain-containing protein 34C (sprot)

An ankyrin repeat domain-containing protein 34C that is encoded in the genome of human.


acid-amino acid ligase activity

Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.


A0A3B3IRQ3_HUMAN Uncharacterized protein (trembl)


cyclic pyranopterin monophosphate synthase activity

Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.


negative cofactor 2 complex

A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.


LR75A_HUMAN Leucine-rich repeat-containing protein 75A (sprot)

A leucine-rich repeat-containing protein 75A that is encoded in the genome of human.


A0A0G2JP20_HUMAN PRAME family member 9 (trembl)


meiotic spindle assembly checkpoint signaling

A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle.


cysteine biosynthetic process from serine

The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.


glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate.


MA13P_HUMAN Putative MAGE domain-containing protein MAGEA13P (sprot)


calcium activated phospholipid scrambling

The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.


ribonuclease P complex

A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs.


single-stranded DNA exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule.


bent DNA binding

Binding to DNA in a bent conformation.


GAL3A_HUMAN Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial (sprot)

A glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial that is encoded in the genome of human.


proton-transporting ATP synthase complex, catalytic core F(1)

The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.


Rad6-Rad18 complex

A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity.


CRIS2_HUMAN Cysteine-rich secretory protein 2 (sprot)

A cysteine-rich secretory protein 2 that is encoded in the genome of human.


3'-nucleotidase activity

Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.


oxytocin receptor binding

Binding to an oxytocin receptor.


DNA replication termination

The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet.


mismatch repair complex

Any complex formed of proteins that act in mismatch repair.


negative regulation of GTP binding

Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding.


D-ribose metabolic process

The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12.


leucine biosynthetic process

The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.


interleukin-9 receptor binding

Binding to an interleukin-9 receptor.


double-stranded DNA endonuclease activity

Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks.


A0A0C4DH90_HUMAN Immunoglobulin kappa variable 3/OR2-268 (non-functional) (Fragment) (trembl)


male meiosis cytokinesis

A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.


dihydroorotate dehydrogenase activity

Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.


AMERL_HUMAN AMMECR1-like protein (sprot)

An AMMECR1-like protein that is encoded in the genome of human.


Okazaki fragment processing involved in mitotic DNA replication

Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication.


L-threonine ammonia-lyase activity

Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.


cytoplasmic translational termination

The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.


mannose-1-phosphate guanylyltransferase (GTP) activity

Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.


cytokine production involved in immune response

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.


LRC53_HUMAN Leucine-rich repeat-containing protein 53 (sprot)

A protein that is a translation product of the LRRC53 gene in human.


steroid 7-alpha-hydroxylase activity

Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O.


NAD salvage

Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam).


SH2D6_HUMAN SH2 domain-containing protein 6 (sprot)

An SH2 domain-containing protein 6 that is encoded in the genome of human.


adenine binding

Binding to adenine, a purine base.


ABRAL_HUMAN Costars family protein ABRACL (sprot)

A costars family protein ABRACL that is encoded in the genome of human.


nucleotide-excision repair factor 3 complex

One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p).


dermatan sulfate metabolic process

The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues.


clathrin-dependent endocytosis of virus by host cell

Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus.


G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.


Sm-like protein family complex

A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles.


glycolipid translocation

The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


D4 dopamine receptor binding

Binding to a D4 dopamine receptor.


FB5L3_HUMAN Putative fatty acid-binding protein 5-like protein 3 (sprot)


Rpd3L-Expanded complex

A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.


aspartyl-tRNA aminoacylation

The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA.


RA1L3_HUMAN Heterogeneous nuclear ribonucleoprotein A1-like 3 (sprot)

A protein that is a translation product of the HNRNPA1L3 gene in human.


GS1L2_HUMAN Germ cell-specific gene 1-like protein 2 (sprot)

A protein that is a translation product of the GSG1L2 gene in human.


hepatocyte growth factor receptor activity

Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


nuclear polyadenylation-dependent CUT catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT.


arginine catabolic process to glutamate

The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate.


protein localization to ciliary inversin compartment

A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment.


NADPH-adrenodoxin reductase activity

Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.


butyrate catabolic process

The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid.


OSER1_HUMAN Oxidative stress-responsive serine-rich protein 1 (sprot)

An oxidative stress-responsive serine-rich protein 1 that is encoded in the genome of human.


S14L6_HUMAN Putative SEC14-like protein 6 (sprot)


TRC complex

A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane.


postsynaptic early endosome

An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.


DNA recombinase auxiliary factor complex

A protein complex that binds to a recombinase and incrseases its activity.


tryptophan catabolic process to acetyl-CoA

The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA.


RNA polymerase III preinitiation complex assembly

The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter.


U2 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U2 snRNA molecule.


rRNA cytidine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.


Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).


A0A3B3IRS2_HUMAN Uncharacterized protein (trembl)


structural constituent of synapse

The action of a molecule that contributes to the structural integrity of a synapse.


D-xylose catabolic process

The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide.


Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide.


presynaptic cytoskeleton

The portion of the cytoskeleton contained within the presynapse.


protein O-GlcNAcylation via threonine

The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine.


RNA polymerase III assembly

The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex.


dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.


SPD16_HUMAN Putative speedy protein E16 (sprot)


ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.


adenosine kinase activity

Catalysis of the reaction: ATP + adenosine = ADP + AMP.


regulation of nervous system development

Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.


dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.


alkylbase DNA N-glycosylase activity

Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.


MROH5_HUMAN Maestro heat-like repeat family member 5 (sprot)


RNA transmembrane transporter activity

Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.


dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity

Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.


SH24B_HUMAN SH2 domain-containing protein 4B (sprot)

An SH2 domain-containing protein 4B that is encoded in the genome of human.


nuclear protein-containing complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.


peptidyl-aspartic acid hydroxylation

The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid.


LRIQ4_HUMAN Leucine-rich repeat and IQ domain-containing protein 4 (sprot)

A leucine-rich repeat and IQ domain-containing protein 4 that is encoded in the genome of human.


Ssh1 translocon complex

A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences.


post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5.


SCP2D_HUMAN SCP2 sterol-binding domain-containing protein 1 (sprot)

An SCP2 sterol-binding domain-containing protein 1 that is encoded in the genome of human.


mitochondrial tRNA wobble uridine modification

The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified.


quinolinate metabolic process

The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.


maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II

Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.


dUTP catabolic process

The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate.


brassinosteroid biosynthetic process

The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects.


DNA ligase III-XRCC1 complex

A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair.


K1522_HUMAN Uncharacterized protein KIAA1522 (sprot)

An uncharacterized protein KIAA1522 that is encoded in the genome of human.


glucosamine 6-phosphate N-acetyltransferase activity

Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+.


lateral element assembly

The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements.


SPDE7_HUMAN Putative speedy protein E7 (sprot)


N-terminal peptidyl-proline methylation

The methylation of the N-terminal proline of proteins.


MAB6B_HUMAN Melanoma-associated antigen B6B (sprot)


nucleotide-excision repair, preincision complex assembly

The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage.


M4A18_HUMAN Membrane-spanning 4-domains subfamily A member 18 (sprot)

A membrane-spanning 4-domains subfamily A member 18 that is encoded in the genome of human.


carotenoid dioxygenase activity

Catalysis of the oxidative cleavage of carotenoids.


microtubule-based transport

A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.


T cell tolerance induction

A process involving any mechanism for tolerance induction in T cells.


trans-synaptic signaling by neuropeptide, modulating synaptic transmission

Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.


regulation of heterochromatin formation

Any process that modulates the frequency, rate, extent or location of heterochromatin formation.


SPD9_HUMAN Putative speedy protein E9 (sprot)


GKN3_HUMAN Gastrokine-3 (sprot)

A protein that is a translation product of the GKN3P gene in human.


mitochondrial coenzyme A transmembrane transport

The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion.


IgE receptor activity

Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


melanocortin receptor binding

Binding to a melanocortin receptor.


Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O.


IQCF6_HUMAN IQ domain-containing protein F6 (sprot)

A protein that is a translation product of the IQCF6 gene in human.


dTDP-glucose 4,6-dehydratase activity

Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.


transverse filament

A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.


type 1 orexin receptor binding

Binding to a type 1 orexin receptor.


laminin complex

A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes.


rixosome complex

A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans.


nuclear pore transmembrane ring

A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.


TM202_HUMAN Transmembrane protein 202 (sprot)

A transmembrane protein 202 that is encoded in the genome of human.


kisspeptin receptor binding

Binding to a kisspeptin receptor.


radial glia guided migration of cerebellar granule cell

The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer.


substance K receptor activity

Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity.


CXCR4 chemokine receptor binding

Binding to a CXCR4 chemokine receptor.


RNA polymerase I assembly

The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex.


snoRNA splicing

The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA.


galanin receptor binding

Binding to a galanin receptor.


Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP.


growth hormone receptor activity

Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


double-strand break repair via single-strand annealing

Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.


IFM10_HUMAN Interferon-induced transmembrane protein 10 (sprot)

An interferon-induced transmembrane protein 10 that is encoded in the genome of human.


A0A087WZ39_HUMAN T cell receptor beta variable 15 (Fragment) (trembl)


thyrotropin-releasing hormone receptor activity

Combining with thyrotropin-releasing hormone to initiate a change in cell activity.


peptidyl-proline hydroxylation to 3-hydroxy-L-proline

The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase.


arginine catabolic process to proline via ornithine

The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine.


Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O.


assembly of large subunit precursor of preribosome

The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome.


23S rRNA (adenine(1618)-N(6))-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.


U2-type post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6.


SPD21_HUMAN Putative speedy protein E21 (sprot)


tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate

A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans.


DPPA5_HUMAN Developmental pluripotency-associated 5 protein (sprot)

A developmental pluripotency-associated 5 protein that is encoded in the genome of human.


general transcription initiation factor activity

A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.


Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.


homogentisate catabolic process

The chemical reactions and pathways resulting in the breakdown of homogentisate.


DC4L1_HUMAN DDB1- and CUL4-associated factor 4-like protein 1 (sprot)

A DDB1- and CUL4-associated factor 4-like protein 1 that is encoded in the genome of human.


SREBP-SCAP complex

A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed.


neuromedin U receptor binding

Binding to one or more specific sites on a neuromedin U receptor.


Noc2p-Noc3p complex

A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.


nucleus-vacuole junction

An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p.


Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.


squalene synthase activity

Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate.


spindle attachment to meiosis I kinetochore

The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs.


SPDE3_HUMAN Speedy protein E3 (sprot)

A speedy protein E3 that is encoded in the genome of human.


negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly

Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly.


cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity

Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP.


oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group.


CTP reductase activity

Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


TTP reductase activity

Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor

Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin.


UDP reductase activity

Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin.


ADP reductase activity

Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin.


CDP reductase activity

Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin.


Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.


DNA-(apurinic or apyrimidinic site) endonuclease, initiator methionine removed form (human)

A DNA-(apurinic or apyrimidinic site) endonuclease (human) that has had the initiator methionine removed. UniProtKB:P27695, 2-318.


eukaryotic translation initiation factor 4E phosphorylated 1 (human)

A eukaryotic translation initiation factor 4E (human) that has been phosphorylated on the residue at the position equivalent to Ser-53 of the amino acid sequence represented by UniProtKB:P06730-1. Example: UniProtKB:P06730-1, Ser-53, MOD:00046.


An Axin that is a translation product of the human AXIN1 gene or a 1:1 ortholog thereof.


Axin-1 isoform 1 (human)

An Axin-1 isoform 1 that is encoded in the genome of human.


Axin-1 ubiquitinated 1 (human)

An Axin-1 (human) that has been ubiquitinated on the residue at the position equivalent to Lys-501 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Lys-501, MOD:01148.


Axin-1 ADP-ribosylated form (human)

An Axin-1 (human) that includes at least one ADP-ribosylated residue. UniProtKB:O15169, MOD:00752.


Axin-1 isoform 2 (human)

An Axin-1 isoform 2 that is encoded in the genome of human.


Axin-1 phosphorylated 1 (human)

An Axin-1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-481, and phosphoserine at positions 486 and 493 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Thr-481, MOD:00047|Ser-486/Ser-493, MOD:00046.


Axin-1 ADP-ribosylated and ubiquitinated form (human)

An Axin-1 (human) that includes at least one ADP-ribosylated residue and at least one ubiquitinated lysine. UniProtKB:O15169, MOD:00752|MOD:01148.


zinc-alpha-2-glycoprotein N-glycosylated 33 (human)

A zinc-alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-128 of the amino acid sequence represented by UniProtKB:P25311-1, in which the glycan composition is represented by GlyTouCan:G60923RB. Example: UniProtKB:P25311-1, Asn-128, MOD:00160~GNO:G60923RB.


encapsulin nanocompartment

Intracellular non-membrane bound organelle, consisting of proteinaceous polyhedral shells that encapsulate enzymes, protecting the contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only one protein, and has only a few proteins inside. Shells about vary from about 25-42 nm in diameter. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla.


serine/threonine-protein kinase VRK2 isoform h4 (human)

A serine/threonine-protein kinase VRK2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86Y07-4.


prolargin O-glycosylated 6 (human)

A prolargin (human) that has been O-glycosylated at the residue equivalent to Thr-56 of the amino acid sequence represented by UniProtKB:P51888-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P51888-1, Thr-56, MOD:00005~GNO:G53434XO.


potassium voltage-gated channel subfamily H member 5 isoform 3 (human)

A voltage-gated potassium channel KCNH5 isoform 3 that is encoded in the genome of human.


Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2.


mucin-1 O-glycosylated 9 (human)

A mucin-1 (human) that has been O-glycosylated at the residue equivalent to Thr-919 of the amino acid sequence represented by UniProtKB:P15941-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P15941-1, Thr-919, MOD:00005~GNO:G58001LT.


ETS domain-containing transcription factor ERF isoform h2 (human)

An ETS domain-containing transcription factor ERF (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P50548-2.


HSPH protein

An Hsp70 family chaperone that has its ATP-binding and substrate-binding domains separated by a linker domain of over 100 amino acids. Proteins in this class function generally as nucleotide exchange factors for cytosolic Hsp70s.


heat shock protein 105 kDa isoform Beta (human)

A heat shock protein 105 kDa isoform 2 that is encoded in the genome of human.


heat shock 70 kDa protein 4L

An HSPH protein that is a translation product of the human HSPA4L gene or a 1:1 ortholog thereof.


heat shock 70 kDa protein 4 isoform 1 (human)

A heat shock 70 kDa protein 4 isoform 1 that is encoded in the genome of human.


heat shock 70 kDa protein 4 isoform h2 (human)

A heat shock 70 kDa protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34932-2.


heat shock protein 105 kDa isoform Alpha (human)

A heat shock protein 105 kDa isoform 1 that is encoded in the genome of human.


heat shock protein 105 kDa isoform h4 (human)

A heat shock protein 105 kDa (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-4.


heat shock protein 105 kDa isoform h3 (human)

A heat shock protein 105 kDa (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-3.


heat shock protein 105 kDa

An HSPH protein that is a translation product of the human HSPH1 gene or a 1:1 ortholog thereof.


heat shock 70 kDa protein 4

An HSPH protein that is a translation product of the human HSPA4 gene or a 1:1 ortholog thereof.


14-3-3 protein gamma isoform 1 (human)

A 14-3-3 protein gamma isoform 1 that is encoded in the genome of human.


Ral guanine nucleotide dissociation stimulator-like 3 isoform h1 (human)

A Ral guanine nucleotide dissociation stimulator-like 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3MIN7-1.


tRNA transmembrane transporter activity

Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other.


adiponectin O-glycosylated 1 (human)

An adiponectin (human) that has been O-glycosylated at the residue equivalent to Thr-21 of the amino acid sequence represented by UniProtKB:Q15848-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q15848-1, Thr-21, MOD:00005~GNO:G53434XO.


DnaJ homolog subfamily C member 12 isoform a (human)

A DnaJ homolog subfamily C member 12 isoform 1 that is encoded in the genome of human.


alpha-N-acetylgalactosaminidase N-glycosylated 30 (human)

An alpha-N-acetylgalactosaminidase (human) that has been N-glycosylated at the residue equivalent to Asn-177 of the amino acid sequence represented by UniProtKB:P17050-1, in which the glycan structure is represented by GlyTouCan:G45359RY. Example: UniProtKB:P17050-1, Asn-177, MOD:00160~GNO:G45359RY.


UDP-glucuronosyltransferase 2B15 N-glycosylated 1 (human)

A UDP-glucuronosyltransferase 2B15 (human) that has been N-glycosylated at the residue equivalent to Asn-316 of the amino acid sequence represented by UniProtKB:P54855-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P54855-1, Asn-316, MOD:00160~GNO:G06247RL.


BCAS3 microtubule associated cell migration factor isoform h4 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-8.


BCAS3 microtubule associated cell migration factor isoform h1 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-2.


BCAS3 microtubule associated cell migration factor isoform 2 (human)

A BCAS3 microtubule associated cell migration factor isoform 1 that is encoded in the genome of human.


BCAS3 microtubule associated cell migration factor isoform h5 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-7.


BCAS3 microtubule associated cell migration factor isoform h3 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-3.


BCAS3 microtubule associated cell migration factor isoform h6 (human)

A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-6.


heat shock factor 2-binding protein isoform h2 (human)

A heat shock factor 2-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75031-2.


heat shock factor 2-binding protein isoform h1 (human)

A heat shock factor 2-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75031-1.


T-cell surface glycoprotein CD4 N-glycosylated 23 (human)

A T-cell surface glycoprotein CD4 (human) that has been N-glycosylated at the residue equivalent to Asn-296 of the amino acid sequence represented by UniProtKB:P01730-1, in which the glycan structure is represented by GlyTouCan:G65890UA. Example: UniProtKB:P01730-1, Asn-296, MOD:00160~GNO:G65890UA.


indole catabolic process

The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


indole biosynthetic process

The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


peptide chain release factor 1-like, mitochondrial isoform h3 (human)

A peptide chain release factor 1-like, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGC7-3.


specification of animal organ axis polarity

The process in which the polarity of an animal organ axis is specified.


ATP-binding cassette sub-family A member 9 isoform h3 (human)

An ATP-binding cassette sub-family A member 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUA7-3.


neogenin isoform h2 (human)

A neogenin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92859-2.


excitatory amino acid transporter 4 isoform h1 (human)

An excitatory amino acid transporter 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48664-1.


mating-type a-factor pheromone receptor activity

Combining with the mating-type a-factor pheromone to initiate a change in cell activity.


nuclear envelope integral membrane protein 2 isoform h1 (human)

A nuclear envelope integral membrane protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A6NFY4-1.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h2 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-2.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3 that is encoded in the genome of human.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h1 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-1.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h4 (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-4.


membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase phosphorylated form (human)

A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that includes at least one phosphorylated residue. UniProtKB:Q99640, MOD:00696.


lymphoid-specific helicase isoform h3 (human)

A lymphoid-specific helicase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRZ9-3.


A cyclin-A that is a translation product of the human CCNA1 gene or a 1:1 ortholog thereof.


cyclin-A1 ubiquitinated form (human)

A cyclin-A1 (human) that includes at least one ubiquitinated lysine. UniProtKB:P78396, MOD:01148.


cyclin-A1 isoform h1 (human)

A cyclin-A1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78396-1.


cyclin-A1 isoform h2 (human)

A cyclin-A1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78396-2.


cyclin-A1 isoform 3 (human)

A cyclin-A1 isoform 3 that is encoded in the genome of human.


dynein regulatory complex subunit 2 isoform h2 (human)

A dynein regulatory complex subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IXS2-2.


dynein regulatory complex subunit 2 isoform h1 (human)

A dynein regulatory complex subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IXS2-1.


membrane-spanning 4-domains subfamily A member 13 isoform h3 (human)

A membrane-spanning 4-domains subfamily A member 13 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5J8X5-3.


hedgehog-interacting protein, signal peptide removed form (human)

A hedgehog-interacting protein (human) that has had the signal peptide removed. UniProtKB:Q96QV1, 18-700.


inactive ADP-ribosyltransferase ARH2 isoform h1 (human)

An inactive ADP-ribosyltransferase ARH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NDY3-1.


inactive ADP-ribosyltransferase ARH2

A protein that is a translation product of the human ADPRHL1 gene or a 1:1 ortholog thereof.


inactive ADP-ribosyltransferase ARH2 isoform h2 (human)

An inactive ADP-ribosyltransferase ARH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NDY3-2.


prostate-specific antigen N-glycosylated 5 (human)

A prostate-specific antigen (human) that has been N-glycosylated at the residue equivalent to Asn-69 of the amino acid sequence represented by UniProtKB:P07288-1, in which the glycan composition is represented by GlyTouCan:G03574QJ. Example: UniProtKB:P07288-1, Asn-69, MOD:00160~GNO:G03574QJ.


platelet-derived growth factor receptor-like protein isoform 1 (human)

A platelet-derived growth factor receptor-like protein isoform 1 that is encoded in the genome of human.


dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

A protein that is a translation product of the human RPN1 gene or a 1:1 ortholog thereof.


dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, signal peptide removed form (human)

A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (human) that has had the signal peptide removed. UniProtKB:P04843, 24-607.


Catalysis of the reaction: H+ + NADH + O2 + quinolin-4-ol = H2O + NAD+ + quinoline-3,4-diol.


PTB-containing, cubilin and LRP1-interacting protein isoform h3 (human)

A PTB-containing, cubilin and LRP1-interacting protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z2X4-3.


PTB-containing, cubilin and LRP1-interacting protein isoform 4 (human)

A PTB-containing, cubilin and LRP1-interacting protein isoform 4 that is encoded in the genome of human.


PTB-containing, cubilin and LRP1-interacting protein isoform h1 (human)

A PTB-containing, cubilin and LRP1-interacting protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z2X4-1.


PTB-containing, cubilin and LRP1-interacting protein isoform h2 (human)

A PTB-containing, cubilin and LRP1-interacting protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z2X4-2.


Ras-specific guanine nucleotide-releasing factor RalGPS2 isoform h3 (human)

A Ras-specific guanine nucleotide-releasing factor RalGPS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86X27-3.


POU domain, class 3, transcription factor 2 isoform hN-OCT 5A (human)

A POU domain, class 3, transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20265-2.


POU domain, class 3, transcription factor 2

A protein that is a translation product of the human POU3F2 gene or a 1:1 ortholog thereof.


POU domain, class 3, transcription factor 2 isoform hN-OCT 3 (human)

A POU domain, class 3, transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20265-1.


POU domain, class 3, transcription factor 2 isoform hN-OCT 5B (human)

A POU domain, class 3, transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20265-3.


testis-specific serine/threonine-protein kinase 3 isoform 1 (human)

A testis-specific serine/threonine-protein kinase 3 isoform 1 that is encoded in the genome of human.


N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity

Catalysis of the reaction: H2O + N(8)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2.


effector-mediated suppression of host pattern-triggered immunity signaling

A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants.


effector-mediated suppression of host innate immune response

A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


effector-mediated suppression of host pattern-triggered immunity

A process mediated by a molecule secreted by a symbiont that results in the suppression of the innate immune response of the host organism via recognition of a microbe-associated molecular pattern. The innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction.


A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.


negative regulation of proline import across plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of proline import into cell.


positive regulation of myofibroblast cell apoptotic process

Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process.


serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1 (human)

A serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1 that is encoded in the genome of human.


ADP-ribosylation factor GTPase-activating protein 1 isoform h2 (human)

An ADP-ribosylation factor GTPase-activating protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N6T3-2.


WD repeat-containing protein 89

A protein that is a translation product of the human WDR89 gene or a 1:1 ortholog thereof.


dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform h2 (human)

A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04844-2.


positive regulation of thyroid gland epithelial cell proliferation

Any process that activates or increases the frequency, rate or extent of thyroid gland epithelial cell proliferation.


positive regulation of epithelial cell proliferation involved in lung bud dilation

Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially.


positive regulation of acinar cell proliferation

Any process that activates or increases the frequency, rate or extent of acinar cell proliferation.


zinc finger FYVE domain-containing protein 9 isoform 2 (human)

A zinc finger FYVE domain-containing protein 9 isoform 2 that is encoded in the genome of human.


dynein regulatory complex subunit 2

A protein that is a translation product of the human CCDC65 gene or a 1:1 ortholog thereof.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform h1 (human)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75251-1.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

A protein that is a translation product of the human NDUFS7 gene or a 1:1 ortholog thereof.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, transit peptide removed form (human)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that has had the transit peptide removed. UniProtKB:O75251, 39-213.


NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform h2 (human)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75251-2.


mismatch repair endonuclease PMS2

A protein that is a translation product of the human PMS2 gene or a 1:1 ortholog thereof.


mismatch repair endonuclease PMS2 isoform h2 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-2.


mismatch repair endonuclease PMS2 isoform h3 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-3.


mismatch repair endonuclease PMS2 isoform h4 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-4.


mismatch repair endonuclease PMS2 isoform h1 (human)

A mismatch repair endonuclease PMS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54278-1.


ceramide synthase 5 isoform h2 (human)

A ceramide synthase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N5B7-2.


structural constituent of ascospore wall

The action of a molecule that contributes to the structural integrity of an ascospore wall.


integrin beta-8 isoform h1 (human)

An integrin beta-8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26012-1.


histone-lysine N-methyltransferase MECOM isoform 7 (human)

A histone-lysine N-methyltransferase MECOM isoform 7 that is encoded in the genome of human.


histone H3.3, initiator methionine removed monomethylated 3 (human)

A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Arg-27 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-27, MOD:00414.


homeobox protein Hox-B1 isoform h1 (human)

A homeobox protein Hox-B1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14653-1.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h1 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-1.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h3 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-3.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h4 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-4.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h2 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-2.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h7 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-7.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h6 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-6.


phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h5 (human)

A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-5.


coiled-coil domain-containing protein 107 isoform h2 (human)

A coiled-coil domain-containing protein 107 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WV48-2.


DnaJ homolog subfamily C member 8 isoform 1 (human)

A DnaJ homolog subfamily C member 8 isoform 1 that is encoded in the genome of human.


DnaJ homolog subfamily C member 8, initiator methionine removed form (human)

A DnaJ homolog subfamily C member 8 (human) that has had the initiator methionine removed. UniProtKB:O75937, 2-253.


soluble scavenger receptor cysteine-rich domain-containing protein SSC5D O-glycosylated 10 (human)

A soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (human) that has been O-glycosylated at the residue equivalent to Thr-1462 of the amino acid sequence represented by UniProtKB:A1L4H1-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:A1L4H1-1, Thr-1462, MOD:00005~GNO:G58001LT.


transmembrane protein 161B isoform h2 (human)

A transmembrane protein 161B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NDZ6-2.


FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h1 (human)

A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-1.


FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h2 (human)

A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-2.


FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h3 (human)

A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-3.


negative regulation of phosphatidylserine biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process.


regulation of phosphatidylserine biosynthetic process

Any process that modulates the frequency, rate or extent of phosphatidylserine biosynthetic process.


positive regulation of phosphatidylserine biosynthetic process

Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process.


keratin-associated protein 3-3

A protein that is a translation product of the human KRTAP3-3 gene or a 1:1 ortholog thereof.


slit homolog 3 protein isoform 1 (human)

A slit homolog 3 protein isoform 1 that is encoded in the genome of human.


putative E3 ubiquitin-protein ligase UNKL isoform h4 (human)

A putative E3 ubiquitin-protein ligase UNKL (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H9P5-4.


Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+.


tyrosine-protein kinase SYK isoform Long (human)

A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of human.


postsynaptic specialization of symmetric synapse, intracellular component

A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses.


kielin/chordin-like protein O-glycosylated 1 (human)

A kielin/chordin-like protein (human) that has been O-glycosylated at the residue equivalent to Thr-38 of the amino acid sequence represented by UniProtKB:Q6ZWJ8-3, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q6ZWJ8-3, Thr-38, MOD:00005~GNO:G53434XO.


kielin/chordin-like protein isoform h3 (human)

A kielin/chordin-like protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZWJ8-3.


kielin/chordin-like protein isoform h4 (human)

A kielin/chordin-like protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZWJ8-4.


kielin/chordin-like protein isoform h2 (human)

A kielin/chordin-like protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZWJ8-2.


kielin/chordin-like protein O-glycosylated 2 (human)

A kielin/chordin-like protein (human) that has been O-glycosylated at the residue equivalent to Thr-413 of the amino acid sequence represented by UniProtKB:Q6ZWJ8-3, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q6ZWJ8-3, Thr-413, MOD:00005~GNO:G43417UB.


actin-binding protein WASF1 isoform 1 (human)

An actin-binding protein WASF1 isoform 1 that is encoded in the genome of human.


7-methylguanosine catabolic process

The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA.


xanthosine catabolic process

The chemical reactions and pathways resulting in the breakdown of xanthosine.


guanosine catabolic process

The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution.


guanosine-containing compound catabolic process

The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines).


transmembrane channel-like protein 3 isoform h2 (human)

A transmembrane channel-like protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z5M5-2.


transmembrane channel-like protein 3

A protein that is a translation product of the human TMC3 gene or a 1:1 ortholog thereof.


transmembrane channel-like protein 3 isoform h1 (human)

A transmembrane channel-like protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z5M5-1.


positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation.


regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation.


negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation.


interleukin-23 subunit alpha, signal peptide removed form (human)

An interleukin-23 subunit alpha, signal peptide removed form in human. UniProtKB:Q9NPF7, 20-189.


negative regulation of glucocorticoid mediated signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid mediated signaling pathway.


GRB2-associated-binding protein 1 phosphorylated 1 (human)

A GRB2-associated-binding protein 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 447, 472, 589, 627 and 659 of the amino acid sequence represented by UniProtKB:Q13480. UniProtKB:Q13480, Tyr-447/Tyr-472/Tyr-589/Tyr-627/Tyr-659, MOD:00048.


GRB2-associated-binding protein 1 isoform h1 (human)

A GRB2-associated-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13480-1.


GRB2-associated-binding protein 1 phosphorylated 2 (human)

A GRB2-associated-binding protein 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 627 and 659 of the amino acid sequence represented by UniProtKB:Q13480. UniProtKB:Q13480, Tyr-627/Tyr-659, MOD:00048.


GRB2-associated-binding protein 1 isoform h2 (human)

A GRB2-associated-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13480-2.


mating type region replication fork barrier binding

Binding to the replication fork barrier found in the mating type region of fission yeast.


elongation factor 1-delta, initiator methionine removed form (human)

An elongation factor 1-delta (human) that has had the initiator methionine removed. UniProtKB:P29692, 2-281.


nuclear migration to embryo sac poles

Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell.


mitogen-activated protein kinase kinase kinase kinase binding

Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase.


protein histidine kinase binding

Binding to a protein histidine kinase.


tubulinyl-Tyr carboxypeptidase 2 isoform h3 (human)

A tubulinyl-Tyr carboxypeptidase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86V25-3.


nuclear factor of activated T-cells, cytoplasmic 4 isoform h16 (human)

A nuclear factor of activated T-cells, cytoplasmic 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14934-16.


serine protease 1, signal peptide removed form (human)

A serine protease 1 (human) that has had the signal peptide removed. UniProtKB:P07477, 16-247.


nodal receptor complex assembly

The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals).


N-acetylneuraminate lyase isoform h2 (human)

An N-acetylneuraminate lyase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BXD5-2.


N-acetylneuraminate lyase

A protein that is a translation product of the human NPL gene or a 1:1 ortholog thereof.


N-acetylneuraminate lyase isoform h4 (human)

An N-acetylneuraminate lyase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BXD5-4.


N-acetylneuraminate lyase isoform h3 (human)

An N-acetylneuraminate lyase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BXD5-3.


N-acetylneuraminate lyase isoform h5 (human)

An N-acetylneuraminate lyase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BXD5-5.


N-acetylneuraminate lyase isoform 1 (human)

An N-acetylneuraminate lyase isoform 1 that is encoded in the genome of human.


calcium/calmodulin-dependent protein kinase type II subunit gamma isoform h2 (human)

A calcium/calmodulin-dependent protein kinase type II subunit gamma (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13555-2.


viral envelope

The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins.


viral membrane

The lipid bilayer of a virion, a complete fully infectious extracellular virus particle.


viral inner membrane

The lipid bilayer of a virion contained inside the protein capsid.


Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O.


pericardial nephrocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


phosphatidylinositol 5-phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylinositol 5-phosphate.


negative regulation of aorta morphogenesis

Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis.


MAML3-RBP-Jkappa-ICN3 complex

A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.


density-regulated protein isoform 1 (human)

A density-regulated protein isoform 1 that is encoded in the genome of human.


positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.


positive regulation of pseudohyphal growth

Any process that activates or increases the frequency, rate or extent of pseudohyphal growth.


PACRG-like protein

A protein that is a translation product of the human PACRGL gene or a 1:1 ortholog thereof.


PACRG-like protein isoform 1 (human)

A PACRG-like protein isoform 1 that is encoded in the genome of human.


PACRG-like protein isoform h2 (human)

A PACRG-like protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N7B6-2.


PACRG-like protein isoform h3 (human)

A PACRG-like protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N7B6-3.


PACRG-like protein isoform h4 (human)

A PACRG-like protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N7B6-4.


leptin receptor overlapping transcript-like 1 isoform 1 (human)

A leptin receptor overlapping transcript-like 1 isoform 1 that is encoded in the genome of human.


tolerance induction in nasopharyngeal-associated lymphoid tissue

Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT).


positive regulation of maltose transport

Any process that activates or increases the frequency, rate or extent of maltose transport.


Rho GTPase-activating protein 45 isoform h2 (human)

A Rho GTPase-activating protein 45 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92619-2.


Rho GTPase-activating protein 45 isoform h1 (human)

A Rho GTPase-activating protein 45 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92619-1.


neurotrimin isoform 1 (human)

A neurotrimin isoform 1 that is encoded in the genome of human.


protein odd-skipped-related 2 isoform 2 (human)

A protein odd-skipped-related 2 isoform 2 that is encoded in the genome of human.


histone H3.2, initiator methionine removed biotinylated 2 (human)

A histone H3.2 (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-19 of the amino acid sequence represented by UniProtKB:Q71DI3. UniProtKB:Q71DI3, 2-136, Lys-19, MOD:00126.


negative regulation of postsynaptic membrane organization

Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization.


negative regulation of AMPA glutamate receptor clustering

Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor clustering.


positive regulation of postsynaptic membrane organization

Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization.


positive regulation of cellular alcohol catabolic process

Any process that activates or increases the frequency, rate or extent of cellular alcohol catabolic process.


positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process.


positive regulation of ethanol catabolic process

Any process that activates or increases the frequency, rate or extent of ethanol catabolic process.


paraneoplastic antigen Ma2

A protein that is a translation product of the human PNMA2 gene or a 1:1 ortholog thereof.


peripheral B cell receptor editing

The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation.


central B cell receptor editing

Receptor editing occurring in B cells in the bone marrow.


interleukin-4-dependent isotype switching to IgE isotypes

The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4).


B cell receptor editing

The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor.


immunoglobulin light chain V-J recombination

The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).


isotype switching to IgD isotypes

The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus.


protein AAR2 homolog isoform 1 (human)

A protein AAR2 homolog isoform 1 that is encoded in the genome of human.


protein KIBRA phosphorylated 1 (human)

A protein KIBRA (human) that has been phosphorylated on the residue at the position equivalent to Ser-539 of the amino acid sequence represented by UniProtKB:Q8IX03-1. Example: UniProtKB:Q8IX03-1, Ser-539, MOD:00046.


protein KIBRA isoform h2 (human)

A protein KIBRA (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IX03-2.


protein KIBRA isoform h1 (human)

A protein KIBRA (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IX03-1.


fibrinogen gamma chain, signal peptide removed form (human)

A fibrinogen gamma chain (human) that has had the signal peptide removed. UniProtKB:P02679, 27-453.


transcription factor AP-2 gamma isoform h2 (human)

A transcription factor AP-2 gamma (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92754-2.


inositol 1,4,5-triphosphate receptor associated 1 isoform 1 phosphorylated 1 (human)

An inositol 1,4,5-triphosphate receptor associated 1 isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6F6-1, Ser-657/Ser-670, MOD:00046.


inositol 1,4,5-triphosphate receptor associated 1 isoform 1 (human)

An inositol 1,4,5-triphosphate receptor associated 1 isoform 1 that is encoded in the genome of human.


Ras-related protein Rab-4A isoform 1 (human)

A Ras-related protein Rab-4A isoform 1 that is encoded in the genome of human.


killer cell immunoglobulin-like receptor 2DL4 isoform h5 (human)

A killer cell immunoglobulin-like receptor 2DL4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99706-5.


disintegrin and metalloproteinase domain-containing protein 15 isoform h10 (human)

A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-10.


disintegrin and metalloproteinase domain-containing protein 15

A protein that is a translation product of the human ADAM15 gene or a 1:1 ortholog thereof.


disintegrin and metalloproteinase domain-containing protein 15 isoform h11 (human)

A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-11.


disintegrin and metalloproteinase domain-containing protein 15 isoform h13 (human)

A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-13.


disintegrin and metalloproteinase domain-containing protein 15 isoform h1 (human)

A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-1.


disintegrin and metalloproteinase domain-containing protein 15 isoform h2 (human)

A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-2.


disintegrin and metalloproteinase domain-containing protein 15 isoform h4 (human)

A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-4.