HMN2_HUMAN Humanin-like 2 (sprot)

A humanin-like 2 that is encoded in the genome of human.


HMN3_HUMAN Humanin-like 3 (sprot)

A humanin-like 3 that is encoded in the genome of human.


HMN4_HUMAN Humanin-like 4 (sprot)

A humanin-like 4 that is encoded in the genome of human.


HMN5_HUMAN Humanin-like 5 (sprot)

A humanin-like 5 that is encoded in the genome of human.


cellular response to staurosporine

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus.


HMN6_HUMAN Humanin-like 6 (sprot)

A humanin-like 6 that is encoded in the genome of human.


HMN7_HUMAN Humanin-like 7 (sprot)

A humanin-like 7 that is encoded in the genome of human.


HMN8_HUMAN Humanin-like 8 (sprot)

A humanin-like 8 that is encoded in the genome of human.


HMN9_HUMAN Humanin-like 9 (sprot)

A humanin-like 9 that is encoded in the genome of human.


HMN10_HUMAN Humanin-like 10 (sprot)

A humanin-like 10 that is encoded in the genome of human.


ZN865_HUMAN Zinc finger protein 865 (sprot)

A zinc finger protein 865 that is encoded in the genome of human.


ZN888_HUMAN Zinc finger protein 888 (sprot)

A zinc finger protein 888 that is encoded in the genome of human.


DU4L2_HUMAN Double homeobox protein 4-like protein 2 (sprot)

A double homeobox protein 4-like protein 2 that is encoded in the genome of human.


DU4L3_HUMAN Double homeobox protein 4-like protein 3 (sprot)

A double homeobox protein 4-like protein 3 that is encoded in the genome of human.


DU4L4_HUMAN Double homeobox protein 4-like protein 4 (sprot)

A double homeobox protein 4-like protein 4 that is encoded in the genome of human.


DU4L5_HUMAN Double homeobox protein 4-like protein 5 (sprot)

A double homeobox protein 4-like protein 5 that is encoded in the genome of human.


DU4L6_HUMAN Double homeobox protein 4-like protein 6 (sprot)

A double homeobox protein 4-like protein 6 that is encoded in the genome of human.


DU4L7_HUMAN Double homeobox protein 4-like protein 7 (sprot)

A double homeobox protein 4-like protein 7 that is encoded in the genome of human.


S352B_HUMAN Solute carrier family 35 member E2B (sprot)

A solute carrier family 35 member E2B that is encoded in the genome of human.


S35E2_HUMAN Solute carrier family 35 member E2A (sprot)

A solute carrier family 35 member E2A that is encoded in the genome of human.


GG12I_HUMAN G antigen 12I (sprot)

A G antigen 12I that is encoded in the genome of human.


ST3L1_HUMAN Putative STAG3-like protein 1 (sprot)

A putative STAG3-like protein 1 that is encoded in the genome of human.


ST3L2_HUMAN Putative STAG3-like protein 2 (sprot)

A putative STAG3-like protein 2 that is encoded in the genome of human.


ST3L3_HUMAN STAG3-like protein 3 (sprot)

A STAG3-like protein 3 that is encoded in the genome of human.


TSPY3_HUMAN Testis-specific Y-encoded protein 3 (sprot)

A testis-specific Y-encoded protein 3 that is encoded in the genome of human.


TSPY4_HUMAN Testis-specific Y-encoded protein 4 (sprot)

A testis-specific Y-encoded protein 4 that is encoded in the genome of human.


TSPY8_HUMAN Testis-specific Y-encoded protein 8 (sprot)

A testis-specific Y-encoded protein 8 that is encoded in the genome of human.


TSPYA_HUMAN Testis-specific Y-encoded protein 10 (sprot)

A testis-specific Y-encoded protein 10 that is encoded in the genome of human.


PRS56_HUMAN Serine protease 56 (sprot)

A serine protease 56 that is encoded in the genome of human.


LIMS3_HUMAN LIM and senescent cell antigen-like-containing domain protein 3 (sprot)

A LIM and senescent cell antigen-like-containing domain protein 3 that is encoded in the genome of human.


LIMS4_HUMAN LIM and senescent cell antigen-like-containing domain protein 4 (sprot)

A protein that is a translation product of the LIMS4 gene in human.


AKAI1_HUMAN A-kinase anchor protein inhibitor 1 (sprot)

An A-kinase anchor protein inhibitor 1 that is encoded in the genome of human.


PNM6A_HUMAN Paraneoplastic antigen-like protein 6A (sprot)

A paraneoplastic antigen-like protein 6A that is encoded in the genome of human.


RN224_HUMAN RING finger protein 224 (sprot)

A RING finger protein 224 that is encoded in the genome of human.


SMIM6_HUMAN Small integral membrane protein 6 (sprot)

A protein that is a translation product of the SMIM6 gene in human.


TPC2A_HUMAN Trafficking protein particle complex subunit 2 (sprot)

A trafficking protein particle complex subunit 2 (human) that is a translation product of the TRAPPC2 gene in human.


TPC2B_HUMAN Trafficking protein particle complex subunit 2B (sprot)

A trafficking protein particle complex subunit 2 (human) that is a translation product of the TRAPPC2B gene in human.


PT100_HUMAN Protein PET100 homolog, mitochondrial (sprot)

A protein PET100 homolog, mitochondrial that is encoded in the genome of human.


SIM13_HUMAN Small integral membrane protein 13 (sprot)

A small integral membrane protein 13 that is encoded in the genome of human.


RBY1A_HUMAN RNA-binding motif protein, Y chromosome, family 1 member A1 (sprot)

An RNA-binding motif protein, Y chromosome, family 1 member A1 that is encoded in the genome of human.


RBY1C_HUMAN RNA-binding motif protein, Y chromosome, family 1 member C (sprot)

An RNA-binding motif protein, Y chromosome, family 1 member C that is encoded in the genome of human.


PEPA4_HUMAN Pepsin A-4 (sprot)

A pepsin A-4 that is encoded in the genome of human.


PEPA3_HUMAN Pepsin A-3 (sprot)

A pepsin A-3 that is encoded in the genome of human.


PEPA5_HUMAN Pepsin A-5 (sprot)

A pepsin A-5 that is encoded in the genome of human.


SAA1_HUMAN Serum amyloid A-1 protein (sprot)

A primate-type serum amyloid A-1 protein that is encoded in the genome of human.


lymphocyte chemotaxis

The directed movement of a lymphocyte in response to an external stimulus.


SAA2_HUMAN Serum amyloid A-2 protein (sprot)

A primate-type serum amyloid A-2 protein that is encoded in the genome of human.


SRG2C_HUMAN SLIT-ROBO Rho GTPase-activating protein 2C (sprot)

A SLIT-ROBO Rho GTPase-activating protein 2C that is encoded in the genome of human.


negative regulation of filopodium assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.


negative regulation of dendritic spine development

Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


GIMD1_HUMAN GTPase IMAP family member GIMD1 (sprot)

A GTPase IMAP family member GIMD1 that is encoded in the genome of human.


MPC1L_HUMAN Mitochondrial pyruvate carrier 1-like protein (sprot)

A mitochondrial pyruvate carrier 1-like protein that is encoded in the genome of human.


S31C1_HUMAN Putative spermatogenesis-associated protein 31C1 (sprot)


ZN728_HUMAN Zinc finger protein 728 (sprot)

A protein that is a translation product of the ZNF728 gene in human.


SIM18_HUMAN Small integral membrane protein 18 (sprot)

A protein that is a translation product of the SMIM18 gene in human.


SIM17_HUMAN Small integral membrane protein 17 (sprot)

A protein that is a translation product of the SMIM17 gene in human.


ELA_HUMAN Apelin receptor early endogenous ligand (sprot)

An apelin receptor early endogenous ligand that is encoded in the genome of human.


apelin receptor binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to an apelin receptor.


mesoderm migration involved in gastrulation

The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.


apelin receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A G protein-coupled receptor signaling pathway initiated by apelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


mesendoderm migration

The process in which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm.


cell migration involved in mesendoderm migration

The orderly movement of epithelial cells from one site to another that contributes to the migration of mesendodermal tissue.


positive regulation of trophoblast cell migration

Any process that activates or increases the frequency, rate or extent of trophoblast cell migration.


positive regulation of G protein-coupled receptor internalization

Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor internalization.


SETLP_HUMAN Protein SETSIP (sprot)

A protein that is a translation product of the SETSIP gene in human.


CSH1_HUMAN Chorionic somatomammotropin hormone 1 (sprot)

A chorionic somatomammotropin hormone 1 that is encoded in the genome of human.


CSH2_HUMAN Chorionic somatomammotropin hormone 2 (sprot)

A chorionic somatomammotropin hormone 2 that is encoded in the genome of human.


ST1A3_HUMAN Sulfotransferase 1A3 (sprot)

A sulfotransferase 1A3 that is encoded in the genome of human.


sulfate binding

Binding to sulfate, SO4(2-), a negatively charged small molecule.


amine sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate.


ST1A4_HUMAN Sulfotransferase 1A4 (sprot)

A sulfotransferase 1A4 that is encoded in the genome of human.


HMN12_HUMAN Humanin-like 12 (sprot)

A protein that is a translation product of the MTRNR2L12 gene in human.


SRG2B_HUMAN SLIT-ROBO Rho GTPase-activating protein 2B (sprot)

A protein that is a translation product of the SRGAP2B gene in human.


INAM2_HUMAN Putative transmembrane protein INAFM2 (sprot)

A protein that is a translation product of the INAFM2 gene in human.


SG1C2_HUMAN Secretoglobin family 1C member 2 (sprot)

A protein that is a translation product of the SCGB1C2 gene in human.


AT8OS_HUMAN Putative protein ATXN8OS (sprot)


AA3R_HUMAN Adenosine receptor A3 (sprot)

An adenosine receptor A3 that is encoded in the genome of human.


TMIG3_HUMAN Transmembrane domain-containing protein TMIGD3 (sprot)

A transmembrane domain-containing protein TMIGD3 that is encoded in the genome of human.


MLN_HUMAN Myoregulin (sprot)

A protein that is a translation product of the MRLN gene in human.


negative regulation of calcium ion import into sarcoplasmic reticulum

Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum.


OR83P_HUMAN Putative olfactory receptor 8G3 pseudogene (sprot)


CT45A_HUMAN Cancer/testis antigen family 45 member A10 (sprot)

A protein that is a translation product of the CT45A10 gene in human.


HS71A_HUMAN Heat shock 70 kDa protein 1A (sprot)

A heat shock 70 kDa protein 1A that is encoded in the genome of human.


denatured protein binding

Binding to a denatured protein.


C3HC4-type RING finger domain binding

Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway.


ATP-dependent protein disaggregase activity

An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates.


cellular heat acclimation

Any process that increases heat tolerance of a cell in response to high temperatures.


positive regulation of microtubule nucleation

Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.


positive regulation of endoribonuclease activity

Any process that activates or increases the frequency, rate or extent of endoribonuclease activity.


HS71B_HUMAN Heat shock 70 kDa protein 1B (sprot)

A heat shock 70 kDa protein 1B that is encoded in the genome of human.


PYDC4_HUMAN NLR family pyrin domain-containing protein 2B (sprot)

A protein that is a translation product of the NLRP2B gene in human.


C1C1L_HUMAN C1GALT1-specific chaperone 1-like protein (sprot)

A protein that is a translation product of the C1GALT1C1L gene in human.


OPSG2_HUMAN Medium-wave-sensitive opsin 2 (sprot)

A medium-wave-sensitive opsin (human) that is a translation product of the OPN1MW2 gene in human.


OPSG3_HUMAN Medium-wave-sensitive opsin 3 (sprot)

A medium-wave-sensitive opsin (human) that is a translation product of the OPN1MW3 gene in human.


OR5H8_HUMAN Olfactory receptor 5H8 (sprot)

A protein that is a translation product of the OR5H8 gene in human.


O13C7_HUMAN Olfactory receptor 13C7 (sprot)

A protein that is a translation product of the OR13C7 gene in human.


O12D1_HUMAN Olfactory receptor 12D1 (sprot)

A protein that is a translation product of the OR12D1 gene in human.


DWORF_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (sprot)

A protein that is a translation product of the STRIT1 gene in human.


regulation of slow-twitch skeletal muscle fiber contraction

Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction.


CGB3_HUMAN Choriogonadotropin subunit beta 3 (sprot)

A choriogonadotropin subunit beta that is a translation product of any of the following genes in human: CGB3/CGB5/CGB8.


CGB7_HUMAN Choriogonadotropin subunit beta 7 (sprot)

A choriogonadotropin subunit beta that is a translation product of the CGB7 gene in human.


IGLC2_HUMAN Immunoglobulin lambda constant 2 (sprot)

A protein that is a translation product of the IGLC2 gene in human.


IGLC3_HUMAN Immunoglobulin lambda constant 3 (sprot)

A protein that is a translation product of the IGLC3 gene in human.


HD101_HUMAN Immunoglobulin heavy diversity 1-1 (sprot)

A protein that is a translation product of the IGHD1-1 gene in human.


HV108_HUMAN Immunoglobulin heavy variable 1-8 (sprot)

A protein that is a translation product of the IGHV1-8 gene in human.


HVC33_HUMAN Immunoglobulin heavy variable 3-30-3 (sprot)

A protein that is a translation product of the IGHV3-30-3 gene in human.


HVC05_HUMAN Immunoglobulin heavy variable 3-30-5 (sprot)

A protein that is a translation product of the IGHV3-30-5 gene in human.


HV43D_HUMAN Immunoglobulin heavy variable 3-43D (sprot)

A protein that is a translation product of the IGHV3-43D gene in human.


HVD34_HUMAN Immunoglobulin heavy variable 4-30-4 (sprot)

A protein that is a translation product of the IGHV4-30-4 gene in human.


HV431_HUMAN Immunoglobulin heavy variable 4-31 (sprot)

A protein that is a translation product of the IGHV4-31 gene in human.


HVD82_HUMAN Immunoglobulin heavy variable 4-38-2 (sprot)

A protein that is a translation product of the IGHV4-38-2 gene in human.


KV113_HUMAN Immunoglobulin kappa variable 1-13 (sprot)

A protein that is a translation product of the IGKV1-13 gene in human.


CALM1_HUMAN Calmodulin-1 (sprot)

A calmodulin (human) that is a translation product of the CALM1 gene.


adenylate cyclase activator activity

Binds to and increases the activity of adenylate cyclase.


regulation of calcium-mediated signaling

Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.


positive regulation of cyclic-nucleotide phosphodiesterase activity

Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.


regulation of ryanodine-sensitive calcium-release channel activity

Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


positive regulation of ryanodine-sensitive calcium-release channel activity

Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


organelle localization by membrane tethering

The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other.


negative regulation of high voltage-gated calcium channel activity

Any process that stops, prevents or reduces the frequency, rate or extent of high voltage-gated calcium channel activity.


regulation of cell communication by electrical coupling involved in cardiac conduction

Any process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction.


negative regulation of calcium ion export across plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion export across the plasma membrane.


CALM2_HUMAN Calmodulin-2 (sprot)

A calmodulin (human) that is a translation product of the CALM2 gene.


CALM3_HUMAN Calmodulin-3 (sprot)

A calmodulin (human) that is a translation product of the CALM3 gene.


T225B_HUMAN Transmembrane protein 225B (sprot)

A protein that is a translation product of the TMEM225B gene in human.


SLUR2_HUMAN Secreted Ly-6/uPAR domain-containing protein 2 (sprot)

A secreted Ly-6/uPAR domain-containing protein 2 that encoded in the genome of human.


LYNX1_HUMAN Ly-6/neurotoxin-like protein 1 (sprot)

An Ly-6/neurotoxin-like protein 1 that is encoded in the genome of human.


acetylcholine receptor inhibitor activity

Binds to and stops, prevents or reduces the activity of an acetylcholine receptor.


D130B_HUMAN Beta-defensin 130B (sprot)

A protein that is a translation product of the DEFB130B gene in human.


D130A_HUMAN Beta-defensin 130A (sprot)

A protein that is a translation product of the DEFB130A gene in human.


VSIG8_HUMAN V-set and immunoglobulin domain-containing protein 8 (sprot)

A V-set and immunoglobulin domain-containing protein 8 that is encoded in the genome of human.


SNH28_HUMAN Putative uncharacterized protein SNHG28 (sprot)


SCHI1_HUMAN Schwannomin-interacting protein 1 (sprot)

A schwannomin-interacting protein 1 that is encoded in the genome of human.


RPAC2_HUMAN DNA-directed RNA polymerases I and III subunit RPAC2 (sprot)


ZN723_HUMAN Zinc finger protein 723 (sprot)

A protein that is a translation product of the ZNF723 gene in human.


ECE2_HUMAN Endothelin-converting enzyme 2 (sprot)

An endothelin-converting enzyme 2 that is encoded in the genome of human.


EFMT4_HUMAN EEF1A lysine methyltransferase 4 (sprot)

An EEF1A lysine methyltransferase 4 that is encoded in the genome of human.


EFCE2_HUMAN EEF1AKMT4-ECE2 readthrough transcript protein (sprot)

An EEF1AKMT4-ECE2 readthrough transcript protein that is encoded in the genome of human.


TMDD1_HUMAN Transmembrane and death domain protein 1 (sprot)

A protein that is a translation product of the TMDD1 gene in human.


NBPFK_HUMAN Neuroblastoma breakpoint family member 20 (sprot)

A neuroblastoma breakpoint family member 20 that is encoded in the genome of human.


NBPF9_HUMAN Neuroblastoma breakpoint family member 9 (sprot)

A neuroblastoma breakpoint family member 9 that is encoded in the genome of human.


TVA35_HUMAN T cell receptor alpha variable 35 (sprot)

A protein that is a translation product of the TRAV35 gene in human.


TVB63_HUMAN T cell receptor beta variable 6-3 (sprot)

A protein that is a translation product of the TRBV6-3 gene in human.


TBA3C_HUMAN Tubulin alpha-3C chain (sprot)

A tubulin alpha-3 chain (human) that is a translation product of the TUBA3C gene in human.


TBA3D_HUMAN Tubulin alpha-3D chain (sprot)

A tubulin alpha-3 chain (human) that is a translation product of the TUBA3D gene in human.


CX05B_HUMAN Uncharacterized protein CXorf51B (sprot)

A protein that is a translation product of the CXorf51B gene in human.


CENL2_HUMAN Centromere protein V-like protein 2 (sprot)

A protein that is a translation product of the CENPVL2 gene in human.


TDB01_HUMAN T cell receptor beta diversity 1 (sprot)

A protein that is a translation product of the TRBD1 gene in human.


H3Y1_HUMAN Histone H3.Y (sprot)

A protein that is a translation product of the H3Y1 gene in human.


NT2NB_HUMAN Notch homolog 2 N-terminal-like protein B (sprot)

A protein that is a translation product of the NOTCH2NLB gene in human.


NT2NC_HUMAN Notch homolog 2 N-terminal-like protein C (sprot)

A protein that is a translation product of the NOTCH2NLC gene in human.


TRDD1_HUMAN T cell receptor delta diversity 1 (sprot)

A protein that is a translation product of the TRDD1 gene in human.


NPY42_HUMAN Neuropeptide Y receptor type 4-2 (sprot)

A protein that is a translation product of the NPY4R2 gene in human.


ZC11C_HUMAN Zinc finger CCCH domain-containing protein 11C (sprot)

A protein that is a translation product of the ZC3H11C gene in human.


SIM46_HUMAN Small integral membrane protein 46 (sprot)

A protein that is a translation product of the SMIM46 gene in human.


T2R33_HUMAN Putative taste receptor type 2 member 33 (sprot)


bitter taste receptor activity

Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste.


KVD37_HUMAN Probable non-functional immunoglobulinn kappa variable 1D-37 (sprot)

A protein that is a translation product of the IGKV1D-37 gene in human.


SCGR9_HUMAN Small cysteine and glycine repeat-containing protein 9 (sprot)

A protein that is a translation product of the SCYGR9 gene in human.


GAGE4_HUMAN G antigen 4 (sprot)

A G antigen 4 that is encoded in the genome of human.


SPD11_HUMAN Putative speedy protein E11 (sprot)


T2R36_HUMAN Putative taste receptor type 2 member 36 (sprot)


HV383_HUMAN Probable non-functional immunoglobulin heavy variable 3-38-3 (sprot)

A protein that is a translation product of the IGHV3-38-3 gene in human.


HV511_HUMAN Probable non-functional immunoglobulin heavy variable 8-51-1 (sprot)

A protein that is a translation product of the IGHV8-51-1 gene in human.


UD2A1_HUMAN UDP-glucuronosyltransferase 2A1 (sprot)

A UDP-glucuronosyltransferase 2A1 that is encoded in the genome of human.


UD2A2_HUMAN UDP-glucuronosyltransferase 2A2 (sprot)

A protein that is a translation product of the UGT2A2 gene in human.


AMY1B_HUMAN Alpha-amylase 1B (sprot)

A protein that is a translation product of the AMY1B gene in human.


AMY1C_HUMAN Alpha-amylase 1C (sprot)

A protein that is a translation product of the AMY1C gene in human.


PTIP2_HUMAN PTTG1IP family member 2 (sprot)

A PTTG1IP family member 2 that is encoded in the genome of human.


LY6S_HUMAN Lymphocyte antigen 6S (sprot)

A protein that is a translation product of the LY6S gene in human.


TM276_HUMAN Transmembrane protein 276 (sprot)

A transmembrane protein 276 that is encoded in the genome of human.


ZTRF1_HUMAN Zinc finger TRAF-type-containing protein 1 (sprot)

A zinc finger TRAF-type-containing protein 1 that is encoded in the genome of human.


TRAR2_HUMAN T cell receptor alpha chain MC.7.G5 (sprot)


TRBR2_HUMAN T cell receptor beta chain MC.7.G5 (sprot)


GAGE1_HUMAN G antigen 1 (sprot)

A G antigen 1 that is encoded in the genome of human.


HV384_HUMAN Probable non-functional immunoglobulin heavy variable 1-38-4 (sprot)

A protein that is a translation product of the IGHV1-38-4 gene in human.


AMY1A_HUMAN Alpha-amylase 1A (sprot)

A protein that is a translation product of the AMY1A gene in human.


HRURF_HUMAN Protein HRURF (sprot)

A protein that is a translation product of the HRURF gene in human.


PRA15_HUMAN PRAME family member 15 (sprot)

A PRAME family member that is a translation product of the PRAMEF15 gene in human.


PRAM9_HUMAN PRAME family member 9 (sprot)

A PRAME family member that is a translation product of the PRAMEF9 gene in human.


Cul2-RING ubiquitin ligase complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


SPD10_HUMAN Speedy protein E10 (sprot)

A protein that is a translation product of the SPDYE10 gene in human.


SPD12_HUMAN Speedy protein E12 (sprot)

A protein that is a translation product of the SPDYE12 gene in human.


LCE7A_HUMAN Late cornified envelope protein 7A (sprot)

A protein that is a translation product of the LCE7A gene in human.


TPRX2_HUMAN Tetrapeptide repeat homeobox protein 2 (sprot)

A protein that is a translation product of the TPRX2 gene in human.


maternal-to-zygotic transition of gene expression

Any process that modulates the frequency, rate or extent of gene expression by which developmental control passes from the maternal genome to the zygotic genome.


SPD18_HUMAN Speedy protein E18 (sprot)

A protein that is a translation product of the SPDYE18 gene in human.


TFKL6_HUMAN TATA-box-binding protein-associated factor 11-like protein 6 (sprot)

A protein that is a translation product of the TAF11L6 gene in human.


TFKL7_HUMAN TATA-box-binding protein-associated factor 11-like protein 7 (sprot)

A protein that is a translation product of the TAF11L7 gene in human.


TFKL8_HUMAN TATA-box-binding protein-associated factor 11-like protein 8 (sprot)

A protein that is a translation product of the TAF11L8 gene in human.


TFKLJ_HUMAN TATA-box-binding protein-associated factor 11-like protein 10 (sprot)

A protein that is a translation product of the TAF11L10 gene in human.


PACMP_HUMAN Poly-ADP-ribosylation-amplifying and CtIP-maintaining micropeptide (sprot)


regulation of protein ADP-ribosylation

Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.


H2BN1_HUMAN Histone H2A.N (sprot)

A protein that is a translation product of the H2BN1 gene in human.


GLI2_HUMAN Zinc finger protein GLI2 (sprot)

A zinc finger protein GLI2 that is encoded in the genome of human.


hindgut morphogenesis

The process in which the anatomical structures of the hindgut are generated and organized.


floor plate formation

The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage.


spinal cord dorsal/ventral patterning

The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord.


smoothened signaling pathway involved in ventral spinal cord interneuron specification

The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.


spinal cord ventral commissure morphogenesis

The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized.


GLI3_HUMAN Transcriptional activator GLI3 (sprot)

A transcriptional activator GLI3 that is encoded in the genome of human.


mediator complex binding

Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


optic nerve morphogenesis

The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.


smoothened signaling pathway involved in spinal cord motor neuron cell fate specification

The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.


forebrain radial glial cell differentiation

The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.


lateral ganglionic eminence cell proliferation

The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population.


nose morphogenesis

The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).


negative regulation of alpha-beta T cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation.


lambdoid suture morphogenesis

The process in which the lambdoid suture is generated and organized.


sagittal suture morphogenesis

The process in which the sagittal suture is generated and organized.


mammary gland specification

The regionalization process in which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes.


anterior semicircular canal development

The progession of the anterior semicircular canal from its initial formation to the mature structure.


lateral semicircular canal development

The progession of the lateral semicircular canal from its initial formation to the mature structure.


cell differentiation involved in kidney development

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state.


larynx morphogenesis

The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.


regulation of bone development

Any process that modulates the frequency, rate or extent of bone development.


ZN875_HUMAN Zinc finger protein 875 (sprot)

A zinc finger protein 875 that is encoded in the genome of human.


ZSC22_HUMAN Zinc finger and SCAN domain-containing protein 22 (sprot)

A zinc finger and SCAN domain-containing protein 22 that is encoded in the genome of human.


TZAP_HUMAN Telomere zinc finger-associated protein (sprot)

A telomere zinc finger-associated protein that is encoded in the genome of human.


double-stranded telomeric DNA binding

Binding to double-stranded telomere-associated DNA.


telomere maintenance via telomere lengthening

Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.


GLI4_HUMAN Zinc finger protein GLI4 (sprot)

A zinc finger protein GLI4 that is encoded in the genome of human.


PYY_HUMAN Peptide YY (sprot)

A peptide YY that is encoded in the genome of human.


CALCB_HUMAN Calcitonin gene-related peptide 2 (sprot)

A calcitonin gene-related peptide 2 that is encoded in the genome of human.


ADX_HUMAN Adrenodoxin, mitochondrial (sprot)

An adrenodoxin, mitochondrial that is encoded in the genome of human.


P450-containing electron transport chain

A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions as the terminal oxidase and participates in a wide range of biochemical pathways.


RAP2A_HUMAN Ras-related protein Rap-2a (sprot)

A Ras-related protein Rap-2a that is encoded in the genome of human.


SRGN_HUMAN Serglycin (sprot)

A serglycin that is encoded in the genome of human.


mast cell secretory granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.


T cell secretory granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.


maintenance of protease location in mast cell secretory granule

A process in which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere.


maintenance of granzyme B location in T cell secretory granule

A process in which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere.


granzyme-mediated programmed cell death signaling pathway

The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.


mast cell granule

Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.


cytolytic granule

A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.


GRAB_HUMAN Granzyme B (sprot)

A granzyme B that is encoded in the genome of human.


cytolytic granule lumen

Any cytoplasmic membrane-bounded vesicle lumen that is part of a cytolytic granule.


IL8_HUMAN Interleukin-8 (sprot)

An interleukin-8 that is encoded in the genome of human.


positive regulation of cellular biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.


interleukin-8 receptor binding

Binding to an interleukin-8 receptor.


regulation of single stranded viral RNA replication via double stranded DNA intermediate

Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.


regulation of entry of bacterium into host cell

Any process that modulates the frequency, rate or extent of entry of bacterium into host cell.


CCL3_HUMAN C-C motif chemokine 3 (sprot)

A C-C motif chemokine 3 that is encoded in the genome of human.


CCR1 chemokine receptor binding

Binding to a CCR1 chemokine receptor.


CCR5 chemokine receptor binding

Binding to a CCR5 chemokine receptor.


eosinophil degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil.


positive regulation of microglial cell activation

Any process that activates or increases the frequency, rate or extent of microglial cell activation.


positive regulation of natural killer cell chemotaxis

Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis.


RNAS2_HUMAN Non-secretory ribonuclease (sprot)

A non-secretory ribonuclease that is encoded in the genome of human.


RO60_HUMAN RNA-binding protein RO60 (sprot)

An RNA-binding protein RO60 that is encoded in the genome of human.


U2 snRNA binding

Binding to a U2 small nuclear RNA (U2 snRNA).


immune system development

The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.


cellular response to interferon-alpha

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.


PRB4_HUMAN Basic salivary proline-rich protein 4 (sprot)

A basic salivary proline-rich protein 4 that is encoded in the genome of human.


COX8A_HUMAN Cytochrome c oxidase subunit 8A, mitochondrial (sprot)

A cytochrome c oxidase subunit 8A, mitochondrial that is encoded in the genome of human.


MYB_HUMAN Transcriptional activator Myb (sprot)

A myb proto-oncogene protein that is encoded in the genome of human.


myeloid cell development

The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.


negative regulation of hematopoietic progenitor cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation.


positive regulation of hepatic stellate cell proliferation

Any process that activates or increases the frequency, rate or extent of hepatic stellate cell proliferation.


positive regulation of hepatic stellate cell activation

Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.


MYBA_HUMAN Myb-related protein A (sprot)

A Myb-related protein A that is encoded in the genome of human.


positive regulation of piRNA transcription

Any process that increases the frequency, rate or extent of the synthesis of piRNA.


MYBB_HUMAN Myb-related protein B (sprot)

A Myb-related protein B that is encoded in the genome of human.


Myb complex

A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.


LYAG_HUMAN Lysosomal alpha-glucosidase (sprot)

A lysosomal alpha-glucosidase that is encoded in the genome of human.


alpha-glucosidase activity

Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose.


maltose metabolic process

The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch.


diaphragm contraction

A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange.


sucrose metabolic process

The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside.


tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.


vacuolar sequestering

The process of transporting a substance into, and confining within, a vacuole.


autolysosome lumen

The volume that is enclosed within the autolysosome single-membrane.


POK10_HUMAN Endogenous retrovirus group K member 10 Pol protein (sprot)


ANDR_HUMAN Androgen receptor (sprot)

An androgen receptor that is encoded in the genome of human.


RNA polymerase II general transcription initiation factor binding

Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.


male somatic sex determination

The determination of sex and sexual phenotypes in a male organism's soma.


negative regulation of integrin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.


positive regulation of integrin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.


regulation of developmental growth

Any process that modulates the frequency, rate or extent of developmental growth.


activation of prostate induction by androgen receptor signaling pathway

The series of molecular signals initiated by androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland.


lateral sprouting involved in mammary gland duct morphogenesis

The process in which a branch forms along the side of a mammary duct.


prostate gland growth

The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state.


epithelial cell differentiation involved in prostate gland development

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland.


positive regulation of epithelial cell proliferation involved in prostate gland development

Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.


non-membrane-bounded organelle assembly

The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.


RARA_HUMAN Retinoic acid receptor alpha (sprot)

A retinoic acid receptor alpha that is encoded in the genome of human.


positive regulation of T-helper 2 cell differentiation

Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.


ventricular cardiac muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.


Sertoli cell fate commitment

The process in which the cellular identity of Sertoli cells is acquired and determined.


trachea cartilage development

The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


regulation of hematopoietic progenitor cell differentiation

Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.


RRAS_HUMAN Ras-related protein R-Ras (sprot)

A Ras-related protein R-Ras that is encoded in the genome of human.


leukocyte differentiation

The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.


Schwann cell migration

The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function.


negative regulation of Schwann cell migration

Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration.


positive regulation of endothelial cell-matrix adhesion via fibronectin

Any process that activates or increases the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin.


HLAC_HUMAN HLA class I histocompatibility antigen, C alpha chain (sprot)

An MHC class I histocompatibility antigen C alpha chain that is encoded in the genome of human.


ACRO_HUMAN Acrosin (sprot)

An acrosin that is encoded in the genome of human.


amidase activity

Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.


acrosome matrix dispersal

The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane.


ARAF_HUMAN Serine/threonine-protein kinase A-Raf (sprot)

A serine/threonine-protein kinase A-Raf that is encoded in the genome of human.


H14_HUMAN Histone H1.4 (sprot)

A histone H1.4 that is encoded in the genome of human.


BCL2_HUMAN Apoptosis regulator Bcl-2 (sprot)

An apoptosis regulator Bcl-2 that is encoded in the genome of human.


channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a channel.


lymphoid progenitor cell differentiation

The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.


negative regulation of B cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.


melanin metabolic process

The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.


regulation of nitrogen utilization

Any process that modulates the frequency, rate or extent of nitrogen utilization.


regulation of glycoprotein biosynthetic process

Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.


mesenchymal cell development

The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.


negative regulation of cellular pH reduction

Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell.


regulation of viral genome replication

Any process that modulates the frequency, rate or extent of viral genome replication.


retinal cell programmed cell death

Programmed cell death that occurs in the developing retina.


negative regulation of retinal cell programmed cell death

Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina.


pigment granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule.


calcium ion transport into cytosol

The directed movement of calcium ions (Ca2+) into the cytosol.


negative regulation of T cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.


dendritic cell apoptotic process

Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.


BAD-BCL-2 complex

A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.


OSTP_HUMAN Osteopontin (sprot)

An osteopontin that is encoded in the genome of human.


negative regulation of collateral sprouting of intact axon in response to injury

Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon.


positive regulation of estradiol secretion

Any process that activates or increases the frequency, rate or extent of estradiol secretion.


ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (sprot)

A dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial that is encoded in the genome of human.


Catalysis of the reaction: (R)-N6-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA.


ARRS_HUMAN S-arrestin (sprot)

An S-arrestin that is encoded in the genome of human.


opsin binding

Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception.


PTPRF_HUMAN Receptor-type tyrosine-protein phosphatase F (sprot)

A receptor-type tyrosine-protein phosphatase F that is encoded in the genome of human.


chondroitin sulfate proteoglycan binding

Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.


negative regulation of receptor binding

Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.


NR2F6_HUMAN Nuclear receptor subfamily 2 group F member 6 (sprot)

A nuclear receptor subfamily 2 group F member 6 that is encoded in the genome of human.


COT1_HUMAN COUP transcription factor 1 (sprot)

A COUP transcription factor 1 that is encoded in the genome of human.


THIO_HUMAN Thioredoxin (sprot)

A thioredoxin that is encoded in the genome of human.


thioredoxin-disulfide reductase (NADP) activity

Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH.


negative regulation of protein export from nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.


response to nitric oxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.


TGFB3_HUMAN Transforming growth factor beta-3 proprotein (sprot)

A TGF-beta 3 that is encoded in the genome of human.


uterine wall breakdown

The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels.


detection of hypoxia

The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.


positive regulation of tight junction disassembly

Any process that activates or increases the frequency, rate or extent of tight junction disassembly.


COX5B_HUMAN Cytochrome c oxidase subunit 5B, mitochondrial (sprot)

A cytochrome c oxidase subunit 5B, mitochondrial that is encoded in the genome of human.


PPGB_HUMAN Lysosomal protective protein (sprot)

A lysosomal protective protein that is encoded in the genome of human.


lumenal side of lysosomal membrane

The side (leaflet) of the lysosomal membrane that faces the lumen.


carboxypeptidase activity

Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain.


regulation of chaperone-mediated autophagy

Any process that modulates the frequency, rate or extent of chaperone-mediated autophagy.


MGST1_HUMAN Microsomal glutathione S-transferase 1 (sprot)

A microsomal glutathione S-transferase 1 that is encoded in the genome of human.


cellular response to lipid hydroperoxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids.


CP2C8_HUMAN Cytochrome P450 2C8 (sprot)

A cytochrome P450 2C8 that is encoded in the genome of human.


arachidonic acid epoxygenase activity

Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid.


organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.


CP2D6_HUMAN Cytochrome P450 2D6 (sprot)

A cytochrome P450 2D6 that is encoded in the genome of human.


negative regulation of binding

Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.


negative regulation of cellular organofluorine metabolic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells.


TAU_HUMAN Microtubule-associated protein tau (sprot)

A microtubule-associated protein tau that is encoded in the genome of human.


dynactin binding

Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity.


histone-dependent DNA binding

DNA-binding activity that is dependent on binding to a histone.


microtubule lateral binding

Binding to the side of a microtubule.


rRNA metabolic process

The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes.


negative regulation of kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


plus-end-directed organelle transport along microtubule

The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.


regulation of mitochondrial fission

Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


negative regulation of mitochondrial fission

Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


axonal transport

The directed movement of organelles or molecules along microtubules in axons.


regulation of long-term synaptic depression

Any process that modulates the frequency, rate or extent of long term synaptic depression.


positive regulation of protein localization to synapse

Any process that activates or increases the frequency, rate or extent of protein localization to synapse.


neurofibrillary tangle assembly

The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle.


negative regulation of establishment of protein localization to mitochondrion

Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion.


positive regulation of protein localization

Any process that activates or increases the frequency, rate or extent of a protein localization.


positive regulation of diacylglycerol kinase activity

Any process that activates or increases the frequency, rate or extent of diacylglycerol kinase activity.


main axon

The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites.


tubulin complex

A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.


CO7_HUMAN Complement component C7 (sprot)

A complement component C7 that is encoded in the genome of human.


KAP0_HUMAN cAMP-dependent protein kinase type I-alpha regulatory subunit (sprot)

A cAMP-dependent protein kinase type I-alpha regulatory subunit that is encoded in the genome of human.


cAMP-dependent protein kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase.


negative regulation of cAMP-dependent protein kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.


sperm connecting piece

The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum.


CMGA_HUMAN Chromogranin-A (sprot)

A chromogranin-A that is encoded in the genome of human.


protein localization to secretory granule

A process in which a protein is transported to, or maintained in, a location within a secretory granule.


negative regulation of catecholamine secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine.


mast cell activation

The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.


positive regulation of relaxation of cardiac muscle

Any process that activates or increases the frequency, rate or extent of relaxation of cardiac muscle.


positive regulation of dense core granule biogenesis

Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis.


TFPI1_HUMAN Tissue factor pathway inhibitor (sprot)

A tissue factor pathway inhibitor that is encoded in the genome of human.


PPBN_HUMAN Alkaline phosphatase, germ cell type (sprot)

An alkaline phosphatase, germ cell type that is encoded in the genome of human.


PF4V_HUMAN Platelet factor 4 variant (sprot)

A platelet factor 4 variant that is encoded in the genome of human.


KIT_HUMAN Mast/stem cell growth factor receptor Kit (sprot)

A mast/stem cell growth factor receptor that is encoded in the genome of human.


stem cell factor receptor activity

Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.


myeloid progenitor cell differentiation

The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.


immature B cell differentiation

The process in which a precursor cell type acquires the specialized features of an immature B cell.


positive regulation of dendritic cell cytokine production

Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.


glycosphingolipid metabolic process

The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.


hematopoietic stem cell migration

The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.


Kit signaling pathway

The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.


mast cell proliferation

The expansion of a mast cell population by cell division.


melanocyte adhesion

The attachment of a melanocyte to another cell via adhesion molecules.


positive regulation of pyloric antrum smooth muscle contraction

Any process that increases the frequency, rate or extent of any pyloric antrum smooth muscle contraction.


positive regulation of colon smooth muscle contraction

Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction.


positive regulation of small intestine smooth muscle contraction

Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction.


positive regulation of vascular associated smooth muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation.


RET3_HUMAN Retinol-binding protein 3 (sprot)

A retinol-binding protein 3 that is encoded in the genome of human.


HEM4_HUMAN Uroporphyrinogen-III synthase (sprot)

A uroporphyrinogen-III synthase that is encoded in the genome of human.


uroporphyrinogen-III synthase activity

Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III.


uroporphyrinogen III biosynthetic process

The chemical reactions and pathways resulting in the formation of uroporphyrinogen III.


response to platinum ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus.


CD28_HUMAN T-cell-specific surface glycoprotein CD28 (sprot)

A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of human.


positive regulation of inflammatory response to antigenic stimulus

Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.


regulation of regulatory T cell differentiation

Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.


protein complex involved in cell adhesion

Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell.


FGF6_HUMAN Fibroblast growth factor 6 (sprot)

A fibroblast growth factor 6 that is encoded in the genome of human.


ESTD_HUMAN S-formylglutathione hydrolase (sprot)

An S-formylglutathione hydrolase that is encoded in the genome of human.


formaldehyde catabolic process

The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde.


CH60_HUMAN 60 kDa heat shock protein, mitochondrial (sprot)

A 60 kDa heat shock protein, mitochondrial that is encoded in the genome of human.


'de novo' protein folding

The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure.


isotype switching to IgG isotypes

The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus.


migrasome

A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration.


RARB_HUMAN Retinoic acid receptor beta (sprot)

A retinoic acid receptor beta that is encoded in the genome of human.


embryonic eye morphogenesis

The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.


THA_HUMAN Thyroid hormone receptor alpha (sprot)

A thyroid hormone receptor alpha that is encoded in the genome of human.


regulation of thyroid hormone mediated signaling pathway

Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.


female courtship behavior

The behavior of a female, for the purpose of attracting a sexual partner.


regulation of myeloid cell apoptotic process

Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process.


regulation of lipid catabolic process

Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids.


negative regulation of DNA-templated transcription initiation

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation.


THB_HUMAN Thyroid hormone receptor beta (sprot)

A thyroid hormone receptor beta that is encoded in the genome of human.


positive regulation of thyroid hormone mediated signaling pathway

Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway.


retinal cone cell apoptotic process

Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina.


CLUS_HUMAN Clusterin (sprot)

A clusterin that is encoded in the genome of human.


immune complex clearance

A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution.


central nervous system myelin maintenance

The process in which the structure and material content of mature central nervous system myelin is kept in a functional state.


protein targeting to lysosome involved in chaperone-mediated autophagy

The targeting of a protein to the lysosome process in which an input protein binds to a chaperone and subsequently to a lysosomal receptor.


regulation of neuronal signal transduction

Any process that modulates the frequency, rate or extent of neuronal signal transduction.


positive regulation of neurofibrillary tangle assembly

Any process that activates or increases the frequency, rate or extent of neurofibrillary tangle assembly.


perinuclear endoplasmic reticulum lumen

The volume enclosed by the membranes of the perinuclear endoplasmic reticulum.


MCF2_HUMAN Proto-oncogene DBL (sprot)

A proto-oncogene DBL that is encoded in the genome of human.


GHR_HUMAN Growth hormone receptor (sprot)

A growth hormone receptor that is encoded in the genome of human.


regulation of response to nutrient levels

Any process that modulates the frequency, rate or extent of a response to nutrient levels.


IRF1_HUMAN Interferon regulatory factor 1 (sprot)

An interferon regulatory factor 1 that is encoded in the genome of human.


regulation of adaptive immune response

Any process that modulates the frequency, rate, or extent of an adaptive immune response.


regulation of MyD88-dependent toll-like receptor signaling pathway

Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway.


negative regulation of regulatory T cell differentiation

Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells.


regulation of CD8-positive, alpha-beta T cell proliferation

Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.


HPLN1_HUMAN Hyaluronan and proteoglycan link protein 1 (sprot)

A hyaluronan and proteoglycan link protein 1 that is encoded in the genome of human.


MLRV_HUMAN Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (sprot)

A myosin regulatory light chain 2, ventricular/cardiac muscle isoform that is encoded in the genome of human.


positive regulation of the force of heart contraction

Any process that increases the force of heart muscle contraction.


CD8B_HUMAN T-cell surface glycoprotein CD8 beta chain (sprot)

A T-cell surface glycoprotein CD8 beta chain that is encoded in the genome of human.


IAPP_HUMAN Islet amyloid polypeptide (sprot)

An islet amyloid polypeptide that is encoded in the genome of human.


BIP_HUMAN Endoplasmic reticulum chaperone BiP (sprot)

An endoplasmic reticulum chaperone BiP that is encoded in the genome of human.


post-translational protein targeting to membrane, translocation

The process in which a protein translocates through the ER membrane posttranslationally.


regulation of protein folding in endoplasmic reticulum

Any process that modulates the rate, frequency or extent of the protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).


regulation of ATF6-mediated unfolded protein response

Any process that modulates the frequency, rate or extent of the ATF6-mediated unfolded protein response.


regulation of IRE1-mediated unfolded protein response

Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response.


regulation of PERK-mediated unfolded protein response

Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response.


LAMC1_HUMAN Laminin subunit gamma-1 (sprot)

A laminin subunit gamma-1 that is encoded in the genome of human.


extracellular matrix constituent conferring elasticity

A component of the extracellular matrix that enables the matrix to recoil after transient stretching.


hemidesmosome assembly

Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina.


CD37_HUMAN Leukocyte antigen CD37 (sprot)

A CD37 molecule that is encoded in the genome of human.


MYH3_HUMAN Myosin-3 (sprot)

A myosin-3 that is encoded in the genome of human.


PNMT_HUMAN Phenylethanolamine N-methyltransferase (sprot)

A phenylethanolamine N-methyltransferase that is encoded in the genome of human.


Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.


PPAL_HUMAN Lysosomal acid phosphatase (sprot)

A lysosomal acid phosphatase that is encoded in the genome of human.


MTAP2_HUMAN Microtubule-associated protein 2 (sprot)

A microtubule-associated protein 2 that is encoded in the genome of human.


positive regulation of anterograde dense core granule transport

Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport.


regulation of organelle transport along microtubule

Any process that modulates the frequency, rate or extent of organelle transport along microtubule.


positive regulation of anterograde synaptic vesicle transport

Any process that activates or increases the frequency, rate or extent of anterograde synaptic vesicle transport.


negative regulation of microtubule binding

Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding.


dendritic branch

A dendrite arising from another dendrite.


primary dendrite

A dendrite emerging from the cell body (the soma) of a neuron.


distal dendrite

The dendrite of the dendritic tree that is farthest away from the neuronal cell body (the soma).


apical distal dendrite

Any dendrite in a dendritic tree that emerges near the apical pole of a neuron, and which is farthest away from the neuronal cell body (the soma).


dendritic filopodium

A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines.


proximal dendrite

The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma).


HSP7C_HUMAN Heat shock cognate 71 kDa protein (sprot)

A heat shock cognate 71 kDa protein that is encoded in the genome of human.


A1 adenosine receptor binding

Binding to an A1 adenosine receptor.


prostaglandin binding

Binding to prostaglandin.


clathrin-uncoating ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP.


protein transmembrane import into intracellular organelle

The directed movement of proteins into an intracellular organelle, across a membrane.


positive regulation by host of viral genome replication

A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication.


positive regulation of lysosomal membrane permeability

Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.


negative regulation of supramolecular fiber organization

Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization.


regulation of protein import

Any process that modulates the frequency, rate or extent of protein import.


positive regulation of protein refolding

Any process that activates or increases the frequency, rate or extent of protein refolding.


chaperone-mediated autophagy translocation complex disassembly

The disaggregation of a chaperone-mediated autophagy translocation complex into its constituent components.


slow axonal transport

The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a Slow Component a (SCa) and a Slow Component b (SCb) which differ in transport rates and protein composition.


clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle.


photoreceptor ribbon synapse

A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.


lysosomal matrix

A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome.


LIPC_HUMAN Hepatic triacylglycerol lipase (sprot)

A hepatic triacylglycerol lipase that is encoded in the genome of human.


intermediate-density lipoprotein particle remodeling

The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle.


EGR2_HUMAN E3 SUMO-protein ligase EGR2 (sprot)

An early growth response protein 2 that is encoded in the genome of human.


rhythmic behavior

The specific behavior of an organism that recur with measured regularity.


Schwann cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.


positive regulation of Schwann cell differentiation

Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation.


rhombomere 3 structural organization

The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.


rhombomere 3 formation

The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


rhombomere 5 structural organization

The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.


rhombomere 5 formation

The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


GTR1_HUMAN Solute carrier family 2, facilitated glucose transporter member 1 (sprot)

A solute carrier family 2, facilitated glucose transporter member 1 that is encoded in the genome of human.


long-chain fatty acid import across plasma membrane

The directed movement of a long-chain fatty acid from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.


L-ascorbic acid metabolic process

The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.


response to Thyroglobulin triiodothyronine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus.


glucose transporter complex

A protein complex facilitating glucose transport into, out of or within a cell, or between cells.


GTR2_HUMAN Solute carrier family 2, facilitated glucose transporter member 2 (sprot)

A solute carrier family 2, facilitated glucose transporter member 2 that is encoded in the genome of human.


fructose transmembrane transporter activity

Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.


galactose transmembrane transporter activity

Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.


hexose transmembrane transporter activity

Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other.


GTR3_HUMAN Solute carrier family 2, facilitated glucose transporter member 3 (sprot)

A solute carrier family 2, facilitated glucose transporter member 3 that is encoded in the genome of human.


EPB41_HUMAN Protein 4.1 (sprot)

A protein 4.1 that is encoded in the genome of human.


regulation of intestinal absorption

Any process that modulates the frequency, rate or extent of intestinal absorption.


UMPS_HUMAN Uridine 5'-monophosphate synthase (sprot)

A uridine 5'-monophosphate synthase that is encoded in the genome of human.


Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.


Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP.


'de novo' pyrimidine nucleobase biosynthetic process

The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.


UMP biosynthetic process

The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate.


UDP biosynthetic process

The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate.


'de novo' UMP biosynthetic process

The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen.


ODPB_HUMAN Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (sprot)

A pyruvate dehydrogenase E1 component subunit beta, mitochondrial that is encoded in the genome of human.


ODB2_HUMAN Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (sprot)

A lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial that is encoded in the genome of human.


Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine.


ITAM_HUMAN Integrin alpha-M (sprot)

An integrin alpha-M that is encoded in the genome of human.


ectodermal cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.


response to curcumin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus.


PYGB_HUMAN Glycogen phosphorylase, brain form (sprot)

A glycogen phosphorylase, brain form that is encoded in the genome of human.


PYGM_HUMAN Glycogen phosphorylase, muscle form (sprot)

A glycogen phosphorylase, muscle form that is encoded in the genome of human.


MBL2_HUMAN Mannose-binding protein C (sprot)

A mannose-binding protein C that is encoded in the genome of human.


ACM1_HUMAN Muscarinic acetylcholine receptor M1 (sprot)

A muscarinic acetylcholine receptor M1 that is encoded in the genome of human.


positive regulation of monoatomic ion transport

Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of glial cell proliferation

Any process that modulates the frequency, rate or extent of glial cell proliferation.


ACHB_HUMAN Acetylcholine receptor subunit beta (sprot)

An acetylcholine receptor subunit beta that is encoded in the genome of human.


postsynaptic membrane organization

A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).


behavioral response to nicotine

Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.


RALA_HUMAN Ras-related protein Ral-A (sprot)

A Ras-related protein Ral-A that is encoded in the genome of human.


Edg-2 lysophosphatidic acid receptor binding

Binding to an Edg-2 lysophosphatidic acid receptor.


membrane raft localization

Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.


establishment of protein localization to mitochondrion

The directed movement of a protein to the mitochondrion or a part of the mitochondrion.


RALB_HUMAN Ras-related protein Ral-B (sprot)

A Ras-related protein Ral-B that is encoded in the genome of human.


regulation of exocyst assembly

Any process that modulates the frequency, rate or extent of exocyst assembly.


regulation of exocyst localization

Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.


ARY2_HUMAN Arylamine N-acetyltransferase 2 (sprot)

An arylamine N-acetyltransferase 2 that is encoded in the genome of human.


arylamine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.


BCR_HUMAN Breakpoint cluster region protein (sprot)

A breakpoint cluster region protein that is encoded in the genome of human.


negative regulation of cellular extravasation

Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation.


negative regulation of neutrophil degranulation

Any process that stops, prevents, or reduces the rate of neutrophil degranulation.


regulation of nitrogen compound metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.


negative regulation of respiratory burst

Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


macrophage migration

The orderly movement of a macrophage from one site to another.


negative regulation of macrophage migration

Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration.


SPTB1_HUMAN Spectrin beta chain, erythrocytic (sprot)

A spectrin beta chain, erythrocytic that is encoded in the genome of human.


LAMP1_HUMAN Lysosome-associated membrane glycoprotein 1 (sprot)

A lysosome-associated membrane glycoprotein 1 that is encoded in the genome of human.


establishment of protein localization to organelle

The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.


phagolysosome membrane

The lipid bilayer surrounding a phagolysosome.


cytolytic granule membrane

The lipid bilayer surrounding the cytolytic granule.


ERG_HUMAN Transcriptional regulator ERG (sprot)

A transcriptional regulator ERG that is encoded in the genome of human.


PIM1_HUMAN Serine/threonine-protein kinase pim-1 (sprot)

A proto-oncogene serine/threonine-protein kinase Pim-1 that is encoded in the genome of human.


vitamin D receptor signaling pathway

The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands.


regulation of hematopoietic stem cell proliferation

Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation.


positive regulation of cardioblast proliferation

Any process that activates or increases the frequency, rate or extent of cardioblast proliferation.


ACADM_HUMAN Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (sprot)

A medium-chain specific acyl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.


acyl-CoA dehydrogenase activity

Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+.


Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.


carnitine metabolic process, CoA-linked

The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA.


fatty acid beta-oxidation using acyl-CoA dehydrogenase

A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).


medium-chain fatty acid metabolic process

The chemical reactions and pathways involving a medium-chain fatty acid, a fatty acid with an aliphatic tail of 6 to 12 carbons.


medium-chain fatty acid catabolic process

The chemical reactions and pathways resulting in the breakdown of a fatty acid with an aliphatic tail of 6 to 12 carbons.


FGFR1_HUMAN Fibroblast growth factor receptor 1 (sprot)

A fibroblast growth factor receptor 1 that is encoded in the genome of human.


fibroblast growth factor receptor activity

Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


regulation of phosphate transport

Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


ventricular zone neuroblast division

The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially.


fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development

The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state.


chordate embryonic development

The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.


phosphatidylinositol-mediated signaling

The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.


regulation of lateral mesodermal cell fate specification

Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification.


auditory receptor cell development

The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


vitamin D3 metabolic process

The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol.


diphosphate metabolic process

The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid.


positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade.


positive regulation of mitotic cell cycle DNA replication

Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication.


positive regulation of parathyroid hormone secretion

Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion.


regulation of extrinsic apoptotic signaling pathway in absence of ligand

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.


TOP1_HUMAN DNA topoisomerase 1 (sprot)

A type 1B DNA topoisomerase 1 that is encoded in the genome of human.


DNA topoisomerase type I (single strand cut, ATP-independent) activity

Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.


embryonic cleavage

The first few specialized divisions of an activated animal egg.


TOP2A_HUMAN DNA topoisomerase 2-alpha (sprot)

A DNA topoisomerase 2-alpha that is encoded in the genome of human.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.


DNA ligation

The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.


positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

Any process that activates or increases the frequency, rate or extent of retroviral genome replication.


negative regulation of DNA duplex unwinding

Any process that stops, prevents or reduces the frequency, rate or extent of DNA duplex unwinding.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity.


G6PD_HUMAN Glucose-6-phosphate 1-dehydrogenase (sprot)

A glucose-6-phosphate 1-dehydrogenase that is encoded in the genome of human.


NADP metabolic process

The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.


pentose biosynthetic process

The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.


ribose phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar.


positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel.


UBL4A_HUMAN Ubiquitin-like protein 4A (sprot)

A ubiquitin-like protein 4A that is encoded in the genome of human.


ubiquitin-like protein transferase activity

Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.


post-translational protein targeting to endoplasmic reticulum membrane

The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.