reactive oxygen species biosynthetic process

The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.


phagolysosome

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.


INSRR_HUMAN Insulin receptor-related protein (sprot)

An insulin receptor-related protein that is encoded in the genome of human.


cellular response to alkaline pH

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.


KPYM_HUMAN Pyruvate kinase PKM (sprot)

A pyruvate kinase PKM that is encoded in the genome of human.


pyruvate kinase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: = ADP + H+ + phosphoenolpyruvate => ATP + pyruvate.


ACYP2_HUMAN Acylphosphatase-2 (sprot)

An acylphosphatase-2 that is encoded in the genome of human.


ENPL_HUMAN Endoplasmin (sprot)

An endoplasmin that is encoded in the genome of human.


actin rod assembly

The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.


regulation of phosphoprotein phosphatase activity

Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.


CCNB1_HUMAN G2/mitotic-specific cyclin-B1 (sprot)

A G2/mitotic-specific cyclin-B1 that is encoded in the genome of human.


positive regulation of attachment of spindle microtubules to kinetochore

Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore.


regulation of mitotic cell cycle spindle assembly checkpoint

Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.


MYL6B_HUMAN Myosin light chain 6B (sprot)

A myosin light chain 6B that is encoded in the genome of human.


HXB3_HUMAN Homeobox protein Hox-B3 (sprot)

A homeobox protein Hox-B3 that is encoded in the genome of human.


rhombomere development

The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.


HXB2_HUMAN Homeobox protein Hox-B2 (sprot)

A homeobox protein Hox-B2 that is encoded in the genome of human.


rhombomere 3 development

The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


rhombomere 4 development

The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


neural nucleus development

The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma.


HXB1_HUMAN Homeobox protein Hox-B1 (sprot)

A homeobox protein Hox-B1 that is encoded in the genome of human.


rhombomere 5 development

The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


facial nucleus development

The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.


anatomical structure formation involved in morphogenesis

The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.


GLUT4_HUMAN Solute carrier family 2, facilitated glucose transporter member 4 (sprot)

A solute carrier family 2, facilitated glucose transporter member 4 that is encoded in the genome of human.


positive regulation of brain-derived neurotrophic factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.


glucose uniporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in).


amylopectin biosynthetic process

The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages.


glucose import in response to insulin stimulus

The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus.


regulation of synaptic vesicle budding from presynaptic endocytic zone membrane

Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane.


insulin-responsive compartment

A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.


RSMB_HUMAN Small nuclear ribonucleoprotein-associated proteins B and B' (sprot)

A small nuclear ribonucleoprotein-associated proteins B and B' that is encoded in the genome of human.


histone pre-mRNA DCP binding

Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing.


U2 snRNP binding

Binding to a U2 small nuclear ribonucleoprotein particle.


7-methylguanosine cap hypermethylation

Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation.


U4 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.


U7 snRNP

A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs.


TYRO_HUMAN Tyrosinase (sprot)

A tyrosinase that is encoded in the genome of human.


tyrosinase activity

Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates.


melanin biosynthetic process from tyrosine

The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.


eye pigment biosynthetic process

The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.


response to blue light

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.


IDE_HUMAN Insulin-degrading enzyme (sprot)

An insulin-degrading enzyme that is encoded in the genome of human.


ubiquitin recycling

Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates.


GPIX_HUMAN Platelet glycoprotein IX (sprot)

A platelet glycoprotein IX that is encoded in the genome of human.


IL1R1_HUMAN Interleukin-1 receptor type 1 (sprot)

An interleukin-1 receptor type 1 that is encoded in the genome of human.


interleukin-1 receptor activity

Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.


interleukin-1, type I, activating receptor activity

Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins.


positive regulation of neutrophil extravasation

Any process that activates or increases the frequency, rate or extent of neutrophil extravasation.


positive regulation of interleukin-1-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway.


MMP9_HUMAN Matrix metalloproteinase-9 (sprot)

A matrix metalloproteinase-9 that is encoded in the genome of human.


positive regulation of receptor binding

Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.


negative regulation of epithelial cell differentiation involved in kidney development

Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development.


negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.


IL2RB_HUMAN Interleukin-2 receptor subunit beta (sprot)

An interleukin-2 receptor subunit beta that is encoded in the genome of human.


interleukin-2 binding

Binding to interleukin-2.


interleukin-15 receptor activity

Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


CX6B1_HUMAN Cytochrome c oxidase subunit 6B1 (sprot)

A cytochrome c oxidase subunit 6B1 that is encoded in the genome of human.


PO2F1_HUMAN POU domain, class 2, transcription factor 1 (sprot)

A POU domain, class 2, transcription factor 1 that is encoded in the genome of human.


HNRPL_HUMAN Heterogeneous nuclear ribonucleoprotein L (sprot)

A heterogeneous nuclear ribonucleoprotein L that is encoded in the genome of human.


pre-mRNA intronic binding

Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA).


GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1 (sprot)

A gamma-aminobutyric acid receptor subunit alpha-1 that is encoded in the genome of human.


GABA receptor activity

Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms.


GABA-gated chloride ion channel activity

Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts.


SYDC_HUMAN Aspartate--tRNA ligase, cytoplasmic (sprot)

An aspartate--tRNA ligase, cytoplasmic that is encoded in the genome of human.


I23O1_HUMAN Indoleamine 2,3-dioxygenase 1 (sprot)

An indoleamine 2,3-dioxygenase 1 that is encoded in the genome of human.


regulation of activated T cell proliferation

Any process that modulates the frequency, rate or extent of activated T cell proliferation.


indoleamine 2,3-dioxygenase activity

Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.


positive regulation of T cell tolerance induction

Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.


positive regulation of chronic inflammatory response

Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.


tryptophan catabolic process to kynurenine

The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.


swimming behavior

The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.


smooth muscle contractile fiber

The contractile fiber of smooth muscle cells.


OXDA_HUMAN D-amino-acid oxidase (sprot)

A D-amino-acid oxidase that is encoded in the genome of human.


D-amino-acid oxidase activity

Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.


D-amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids.


D-serine catabolic process

The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.


D-alanine catabolic process

The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine.


D-serine metabolic process

The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.


ETS1_HUMAN Protein C-ets-1 (sprot)

A protein C-ets-1 that is encoded in the genome of human.


PLAK_HUMAN Junction plakoglobin (sprot)

A junction plakoglobin that is encoded in the genome of human.


hemidesmosome

A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces.


cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication

Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.


cytoskeletal protein-membrane anchor activity

The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location.


desmosome assembly

A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.


endothelial cell-cell adhesion

The attachment of an endothelial cell to another endothelial cell via adhesion molecules.


bundle of His cell-Purkinje myocyte adhesion involved in cell communication

The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.


regulation of ventricular cardiac muscle cell action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


gamma-catenin-TCF7L2 complex

A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.


QCR7_HUMAN Cytochrome b-c1 complex subunit 7 (sprot)

A cytochrome b-c1 complex subunit 7 that is encoded in the genome of human.


LIF_HUMAN Leukemia inhibitory factor (sprot)

A leukemia inhibitory factor that is encoded in the genome of human.


leukemia inhibitory factor receptor binding

Binding to an leukemia inhibitory factor receptor.


negative regulation of meiotic nuclear division

Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.


leukemia inhibitory factor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by the binding of a leukemia inhibitory factor to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.


regulation of metanephric nephron tubule epithelial cell differentiation

Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation.


meiotic nuclear division

One of the two nuclear divisions that occur as part of the meiotic cell cycle.


ETS2_HUMAN Protein C-ets-2 (sprot)

A protein C-ets-2 that is encoded in the genome of human.


ectodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the ectoderm.


BRAF_HUMAN Serine/threonine-protein kinase B-raf (sprot)

A B-Raf proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human.


CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells.


trehalose metabolism in response to stress

The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress.


negative regulation of synaptic vesicle exocytosis

Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis.


CBPA1_HUMAN Carboxypeptidase A1 (sprot)

A carboxypeptidase A1 that is encoded in the genome of human.


CBPB1_HUMAN Carboxypeptidase B (sprot)

A carboxypeptidase B that is encoded in the genome of human.


CBPA3_HUMAN Mast cell carboxypeptidase A (sprot)

A mast cell carboxypeptidase A that is encoded in the genome of human.


FABP4_HUMAN Fatty acid-binding protein, adipocyte (sprot)

A fatty acid-binding protein, adipocyte that is encoded in the genome of human.


GLNA_HUMAN Glutamine synthetase (sprot)

A glutamine synthetase that is encoded in the genome of human.


glutamine synthetase activity

Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate.


glutamine biosynthetic process

The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid.


protein palmitoylation

The covalent attachment of a palmitoyl group to a protein.


ALDR_HUMAN Aldo-keto reductase family 1 member B1 (sprot)

An aldo-keto reductase family 1 member B1 that is encoded in the genome of human.


prostaglandin H2 endoperoxidase reductase activity

Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).


glyceraldehyde oxidoreductase activity

Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H+.


fructose biosynthetic process

The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose.


AMPN_HUMAN Aminopeptidase N (sprot)

An aminopeptidase N that is encoded in the genome of human.


PVR_HUMAN Poliovirus receptor (sprot)

A poliovirus receptor that is encoded in the genome of human.


susceptibility to natural killer cell mediated cytotoxicity

The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.


susceptibility to T cell mediated cytotoxicity

The process of causing a cell to become susceptible to T cell mediated cytotoxicity.


RAC2_HUMAN Ras-related C3 botulinum toxin substrate 2 (sprot)

A Ras-related C3 botulinum toxin substrate 2 that is encoded in the genome of human.


regulation of hydrogen peroxide metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide.


regulation of cell-substrate adhesion

Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


regulation of T cell proliferation

Any process that modulates the frequency, rate or extent of T cell proliferation.


regulation of respiratory burst

Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


regulation of mast cell chemotaxis

Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus.


regulation of neutrophil migration

Any process that modulates the frequency, rate or extent of neutrophil migration.


CBPN_HUMAN Carboxypeptidase N catalytic chain (sprot)

A carboxypeptidase N catalytic chain that is encoded in the genome of human.


ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (sprot)

A eukaryotic peptide chain release factor GTP-binding subunit ERF3A that is encoded in the genome of human.


regulation of translational termination

Any process that modulates the frequency, rate or extent of translational termination.


translation release factor complex

A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.


MYOD1_HUMAN Myoblast determination protein 1 (sprot)

A myoblast determination protein 1 that is encoded in the genome of human.


positive regulation of skeletal muscle tissue regeneration

Any process that activates or increase the rate of skeletal muscle regeneration.


skeletal muscle fiber adaptation

Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.


positive regulation of snRNA transcription by RNA polymerase II

Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II.


MYOG_HUMAN Myogenin (sprot)

A myogenin that is encoded in the genome of human.


positive regulation of myotube differentiation

Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


response to electrical stimulus involved in regulation of muscle adaptation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation.


response to denervation involved in regulation of muscle adaptation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation.


regulation of myoblast fusion

Any process that modulates the frequency, rate or extent of myoblast fusion.


IL9_HUMAN Interleukin-9 (sprot)

An interleukin-9 that is encoded in the genome of human.


PGAM2_HUMAN Phosphoglycerate mutase 2 (sprot)

A phosphoglycerate mutase 2 that is encoded in the genome of human.


phosphoglycerate mutase activity

Catalysis of the reaction: 2-phosphoglycerate = 3-phosphoglycerate.


INGR1_HUMAN Interferon gamma receptor 1 (sprot)

An interferon gamma receptor alpha chain that is encoded in the genome of human.


type II interferon receptor activity

Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


ARSA_HUMAN Arylsulfatase A (sprot)

An arylsulfatase A that is encoded in the genome of human.


cerebroside-sulfatase activity

Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate.


B4GT1_HUMAN Beta-1,4-galactosyltransferase 1 (sprot)

A beta-1,4-galactosyltransferase 1 that is encoded in the genome of human.


development of secondary sexual characteristics

The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.


positive regulation of circulating fibrinogen levels

Any process that increases the quantity of fibrinogen circulating in the bloodstream.


Golgi trans cisterna

The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.


PPAP_HUMAN Prostatic acid phosphatase (sprot)

A prostatic acid phosphatase that is encoded in the genome of human.


acid phosphatase activity

Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.


5'-nucleotidase activity

Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.


thiamine phosphate phosphatase activity

Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate.


XMP 5'-nucleosidase activity

Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine.


thiamine metabolic process

The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.


positive regulation of adenosine receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands.


EZRI_HUMAN Ezrin (sprot)

An ezrin that is encoded in the genome of human.


cortical microtubule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.


protein localization to cell cortex

A process in which a protein is transported to, or maintained in, the cell cortex.


regulation of organelle assembly

Any process that modulates the frequency, rate or extent of organelle assembly.


negative regulation of p38MAPK cascade

Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.


positive regulation of early endosome to late endosome transport

Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport.


VATB1_HUMAN V-type proton ATPase subunit B, kidney isoform (sprot)

A V-type proton ATPase subunit B, kidney isoform that is encoded in the genome of human.


renal sodium excretion

The elimination of sodium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.


pH reduction

Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.


renal tubular secretion

The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.


FOLR1_HUMAN Folate receptor alpha (sprot)

A folate receptor alpha that is encoded in the genome of human.


neural crest cell migration involved in heart formation

The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.


anterior neural tube closure

The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline.


ATF2_HUMAN Cyclic AMP-dependent transcription factor ATF-2 (sprot)

A cyclic AMP-dependent transcription factor ATF-2 that is encoded in the genome of human.


histone H2B acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine.


brainstem development

The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.


growth plate cartilage chondrocyte differentiation

The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage.


vacuole organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.


abducens nucleus development

The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure.


hypoglossal nucleus development

The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure.


detection of cell density

The series of events in which information about the density of cells in a population is received and converted into a molecular signal.


cellular response to leucine starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine.


H4 histone acetyltransferase complex

A protein complex which is capable of H4 histone acetyltransferase activity.


UCHL3_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L3 (sprot)

A ubiquitin carboxyl-terminal hydrolase isozyme L3 that is encoded in the genome of human.


deNEDDylase activity

An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.


KCNE1_HUMAN Potassium voltage-gated channel subfamily E member 1 (sprot)

A potassium voltage-gated channel subfamily E member 1 that is encoded in the genome of human.


voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


vestibular nucleus development

The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure.


cellular response to acidic pH

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.


cellular response to light stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.


ventricular cardiac muscle cell action potential

An action potential that occurs in a ventricular cardiac muscle cell.


membrane repolarization during action potential

The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


regulation of delayed rectifier potassium channel activity

Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity.


negative regulation of delayed rectifier potassium channel activity

Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity.


CD19_HUMAN B-lymphocyte antigen CD19 (sprot)

A CD19 molecule that is encoded in the genome of human.


B-1 B cell differentiation

The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.


antigen receptor-mediated signaling pathway

The series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell.


regulation of B cell activation

Any process that modulates the frequency, rate or extent of B cell activation.


FOSL1_HUMAN Fos-related antigen 1 (sprot)

A Fos-related antigen 1 that is encoded in the genome of human.


vitellogenesis

The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.


FOSL2_HUMAN Fos-related antigen 2 (sprot)

A Fos-related antigen 2 that is encoded in the genome of human.


cell death

Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).


response to interleukin-13

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.


chondrocyte proliferation

The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.


lung connective tissue development

The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs.


alveolar secondary septum development

The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule.


response to interleukin-7

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus.


fat cell apoptotic process

Any apoptotic process in a fat cell.


regulation of myofibroblast differentiation

Any process that modulates the frequency, rate or extent of myofibroblast differentiation.


response to leukemia inhibitory factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.


GLPE_HUMAN Glycophorin-E (sprot)

A glycophorin-E that is encoded in the genome of human.


PGDH_HUMAN 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (sprot)

A 15-hydroxyprostaglandin dehydrogenase [NAD(+)] that is encoded in the genome of human.


prostaglandin E receptor activity

Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.


oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.


ductus arteriosus closure

The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs.


regulation of prostaglandin catabolic process

Any process that modulates the frequency, rate or extent of prostaglandin catabolic process.


VAV_HUMAN Proto-oncogene vav (sprot)

A proto-oncogene vav that is encoded in the genome of human.


ELN_HUMAN Elastin (sprot)

An elastin that is encoded in the genome of human.


CSF2R_HUMAN Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (sprot)

A granulocyte-macrophage colony-stimulating factor receptor subunit alpha that is encoded in the genome of human.


AREG_HUMAN Amphiregulin (sprot)

An amphiregulin that is encoded in the genome of human.


dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis

The process in which the terminal end of a mammary duct bifurcates.


HIS1_HUMAN Histatin-1 (sprot)

A histatin-1 that is encoded in the genome of human.


positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.


positive regulation of vascular wound healing

Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


positive regulation of wound healing, spreading of epidermal cells

Any process that activates or increases the frequency, rate or extent of wound healing, spreading of epidermal cells.


HIS3_HUMAN Histatin-3 (sprot)

A histatin-3 that is encoded in the genome of human.


MCP_HUMAN Membrane cofactor protein (sprot)

A membrane cofactor protein that is encoded in the genome of human.


sequestering of extracellular ligand from receptor

The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.


inner acrosomal membrane

The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.


NDKA_HUMAN Nucleoside diphosphate kinase A (sprot)

A nucleoside diphosphate kinase A that is encoded in the genome of human.


3'-5' exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.


C11B1_HUMAN Cytochrome P450 11B1, mitochondrial (sprot)

A cytochrome P450 11B that is a translation product of the CYP11B1 gene in human.


steroid 11-beta-monooxygenase activity

Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.


NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 (sprot)

An NAD(P)H dehydrogenase [quinone] 1 that is encoded in the genome of human.


NADH dehydrogenase (quinone) activity

Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.


ubiquinone metabolic process

The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme.


vitamin E metabolic process

The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


vitamin K metabolic process

The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.


NADPH oxidation

A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP.


response to L-glutamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus.


response to hydrogen sulfide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus.


response to flavonoid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus.


An N-acetylglucosamine-6-sulfatase that is encoded in the genome of human.


Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.


keratan sulfate catabolic process

The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.


ZNF44_HUMAN Zinc finger protein 44 (sprot)

A zinc finger protein 44 that is encoded in the genome of human.


ZN250_HUMAN Zinc finger protein 250 (sprot)

A zinc finger protein 250 that is encoded in the genome of human.


VEGFA_HUMAN Vascular endothelial growth factor A, long form (sprot)

A vascular endothelial growth factor A that is encoded in the genome of human.


vascular endothelial growth factor receptor 1 binding

Binding to a vascular endothelial growth factor receptor 1.


lymphangiogenesis

Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.


coronary vein morphogenesis

The process in which the anatomical structures of veins of the heart are generated and organized.


lymph vessel morphogenesis

The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph.


positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.


primitive erythrocyte differentiation

Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis.


cardiac vascular smooth muscle cell development

The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state.


vascular wound healing

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


cellular stress response to acid chemical

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.


positive regulation of lymphangiogenesis

Any process that activates or increases the frequency, rate or extent of lymphangiogenesis.


negative regulation of establishment of endothelial barrier

Any process that stops, prevents or reduces the frequency, rate or extent of establishment of endothelial barrier.


negative regulation of adherens junction organization

Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization.


negative regulation of blood-brain barrier permeability

Any process that decreases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain.


VEGF-A complex

A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase.


PHKG2_HUMAN Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (sprot)

A phosphorylase b kinase gamma catalytic chain, liver/testis isoform that is encoded in the genome of human.


phosphorylase kinase activity

Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.


positive regulation of glycogen catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.


phosphorylase kinase complex

An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.


CD1E_HUMAN T-cell surface glycoprotein CD1e, membrane-associated (sprot)

A T-cell surface glycoprotein CD1e that is encoded in the genome of human.


CD1D_HUMAN Antigen-presenting glycoprotein CD1d (sprot)

An antigen-presenting glycoprotein CD1d that is encoded in the genome of human.


lipid antigen binding

Binding to a lipid antigen.


exogenous lipid antigen binding

Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids).


antigen processing and presentation, endogenous lipid antigen via MHC class Ib

The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.


IGLL1_HUMAN Immunoglobulin lambda-like polypeptide 1 (sprot)

An immunoglobulin lambda-like polypeptide 1 that is encoded in the genome of human.


ZEP1_HUMAN Zinc finger protein 40 (sprot)

A zinc finger protein 40 that is encoded in the genome of human.


ARSB_HUMAN Arylsulfatase B (sprot)

An arylsulfatase B that is encoded in the genome of human.


Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.


arylsulfatase activity

Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate.


colon epithelial cell migration

The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism.


PAX1_HUMAN Paired box protein Pax-1 (sprot)

A paired box protein Pax-1 that is encoded in the genome of human.


RS2_HUMAN Small ribosomal subunit protein uS5 (sprot)

A 40S ribosomal protein S2 that is encoded in the genome of human.


positive regulation of ubiquitin-protein transferase activity

Any process that activates, maintains or increases the rate of ubiquitin transferase activity.


CHIN_HUMAN N-chimaerin (sprot)

An N-chimaerin that is encoded in the genome of human.


ITF2_HUMAN Transcription factor 4 (sprot)

A transcription factor 4 that is encoded in the genome of human.


beta-catenin-TCF7L2 complex

A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.


SIAT1_HUMAN Beta-galactoside alpha-2,6-sialyltransferase 1 (sprot)

A beta-galactoside alpha-2,6-sialyltransferase 1 that is encoded in the genome of human.


Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+.


N-acetylneuraminate metabolic process

The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid.


regulation of substrate adhesion-dependent cell spreading

Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading.


RAG1_HUMAN V(D)J recombination-activating protein 1 (sprot)

A V(D)J recombination-activating protein 1 that is encoded in the genome of human.


pre-B cell allelic exclusion

Expression of a single heavy chain allele during pre-B cell differentiation.


TFE2_HUMAN Transcription factor E2-alpha (sprot)

A transcription factor E2-alpha that is encoded in the genome of human.


immunoglobulin V(D)J recombination

The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined.


DESP_HUMAN Desmoplakin (sprot)

A desmoplakin that is encoded in the genome of human.


desmosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.


ventricular compact myocardium morphogenesis

The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.


protein localization to cell-cell junction

A process in which a protein is transported to, or maintained, in a location within a cell-cell junction.


RFA2_HUMAN Replication protein A 32 kDa subunit (sprot)

A replication protein A 32 kDa subunit that is encoded in the genome of human.


protein localization to chromosome

Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.


regulation of DNA damage checkpoint

Any process that modulates the frequency, rate or extent of a DNA damage checkpoint.


MUC1_HUMAN Mucin-1 (sprot)

A mucin-1 that is encoded in the genome of human.


COX7C_HUMAN Cytochrome c oxidase subunit 7C, mitochondrial (sprot)

A cytochrome c oxidase subunit 7C, mitochondrial that is encoded in the genome of human.


GATA1_HUMAN Erythroid transcription factor (sprot)

An erythroid transcription factor that is encoded in the genome of human.


C2H2 zinc finger domain binding

Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.


regulation of definitive erythrocyte differentiation

Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis.


regulation of primitive erythrocyte differentiation

Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis.


basophil differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell.


eosinophil fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin.


TIMP2_HUMAN Metalloproteinase inhibitor 2 (sprot)

A metalloproteinase inhibitor 2 that is encoded in the genome of human.


LOX15_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX15 (sprot)

A polyunsaturated fatty acid lipoxygenase ALOX15 that is encoded in the genome of human.


The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.


regulation of peroxisome proliferator activated receptor signaling pathway

Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.


cellular response to interleukin-13

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.


regulation of engulfment of apoptotic cell

Any process that modulates the frequency, rate or extent of engulfment of apoptotic cell.


ANPRA_HUMAN Atrial natriuretic peptide receptor 1 (sprot)

An atrial natriuretic peptide receptor 1 that is encoded in the genome of human.


guanylate cyclase activity

Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.


natriuretic peptide receptor activity

Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.


positive regulation of cGMP-mediated signaling

Any process that increases the rate, frequency or extent of cGMP-mediated signaling.


ANPR-A receptor complex

A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure.


CD44_HUMAN CD44 antigen (sprot)

A CD44 molecule that is encoded in the genome of human.


positive regulation of monocyte aggregation

Any process that activates or increases the frequency, rate or extent of monocyte aggregation.


NQO2_HUMAN Ribosyldihydronicotinamide dehydrogenase [quinone] (sprot)

A ribosyldihydronicotinamide dehydrogenase [quinone] that is encoded in the genome of human.


dihydronicotinamide riboside quinone reductase activity

Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.


oxidoreductase activity, acting on other nitrogenous compounds as donors

Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


melatonin binding

Binding to melatonin.


resveratrol binding

Binding to resveratrol.


quinone catabolic process

The chemical reactions and pathways resulting in the breakdown of quinone.


H2AX_HUMAN Histone H2AX (sprot)

A histone H2AX that is encoded in the genome of human.


LYAM3_HUMAN P-selectin (sprot)

A P-selectin that is encoded in the genome of human.


PGCA_HUMAN Aggrecan core protein (sprot)

An aggrecan core protein that is encoded in the genome of human.


F261_HUMAN 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (sprot)

A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 that is encoded in the genome of human.


Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.


fructose-6-phosphate binding

Binding to fructose 6-phosphate.


fructose 2,6-bisphosphate metabolic process

The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.


A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.


ITB4_HUMAN Integrin beta-4 (sprot)

An integrin beta-4 that is encoded in the genome of human.


peripheral nervous system myelin formation

The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system.


trophoblast cell migration

Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst.


LEUK_HUMAN Leukosialin (sprot)

A leukosialin that is encoded in the genome of human.


response to protozoan

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.


negative regulation of type IV hypersensitivity

Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.


T-helper 1 cell lineage commitment

The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis.


regulation of T cell migration

Any process that modulates the frequency, rate or extent of T cell migration.


CBR1_HUMAN Carbonyl reductase [NADPH] 1 (sprot)

A carbonyl reductase [NADPH] 1 that is encoded in the genome of human.


15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate.


15-hydroxyprostaglandin dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP+ + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H+ + NADPH.


prostaglandin-E2 9-reductase activity

Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.


cyclooxygenase pathway

The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.


ANK1_HUMAN Ankyrin-1 (sprot)

An ankyrin-1 that is encoded in the genome of human.


ACADS_HUMAN Short-chain specific acyl-CoA dehydrogenase, mitochondrial (sprot)

A short-chain specific acyl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.


butyryl-CoA dehydrogenase activity

Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.


CREB1_HUMAN Cyclic AMP-responsive element-binding protein 1 (sprot)

A cyclic AMP-responsive element-binding protein 1 that is encoded in the genome of human.


hormone secretion

The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.


positive regulation of cardiac muscle tissue development

Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development.


ATF4-CREB1 transcription factor complex

Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.


LIPP_HUMAN Pancreatic triacylglycerol lipase (sprot)

A pancreatic triacylglycerol lipase that is encoded in the genome of human.


all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity

Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate.


positive regulation of triglyceride lipase activity

Any process that increases the activity of triglyceride lipase.


PGFRA_HUMAN Platelet-derived growth factor receptor alpha (sprot)

An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human.


platelet-derived growth factor alpha-receptor activity

Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity.


regulation of mesenchymal stem cell differentiation

Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation.


GDC_HUMAN Solute carrier family 25 member 16 (sprot)

A solute carrier family 25 member 16 that is encoded in the genome of human.


BGAL_HUMAN Beta-galactosidase (sprot)

A eukaryotic-type beta-galactosidase that is encoded in the genome of human.


beta-galactosidase activity

Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.


response to cortisone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues.


PECA1_HUMAN Platelet endothelial cell adhesion molecule (sprot)

A platelet endothelial cell adhesion molecule that is encoded in the genome of human.


monocyte extravasation

The migration of a monocyte from the blood vessels into the surrounding tissue.


positive regulation of protein localization to cell-cell junction

Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction.


PP2BB_HUMAN Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (sprot)

A serine/threonine-protein phosphatase 2B catalytic subunit beta isoform that is encoded in the genome of human.


calmodulin-dependent protein phosphatase activity

Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.


calcium-ion regulated exocytosis

The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.


negative regulation of signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.


negative regulation of calcium ion import across plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane.


calcineurin complex

A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.


protein serine/threonine phosphatase complex

A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.


NCK1_HUMAN Cytoplasmic protein NCK1 (sprot)

A cytoplasmic protein NCK1 that is encoded in the genome of human.


eukaryotic initiation factor eIF2 binding

Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation.


positive regulation of cap-dependent translational initiation

Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation.


positive regulation of cap-independent translational initiation

Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation.


negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation.


GCFC2_HUMAN Intron Large complex component GCFC2 (sprot)

An intron Large complex component GCFC2 that is encoded in the genome of human.


KCNA2_HUMAN Potassium voltage-gated channel subfamily A member 2 (sprot)

A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of human.


voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.


voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.


optic nerve structural organization

The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.


juxtaparanode region of axon

A region of an axon near a node of Ranvier that is between the paranode and internode regions.


H15_HUMAN Histone H1.5 (sprot)

A histone H1.5 that is encoded in the genome of human.


H13_HUMAN Histone H1.3 (sprot)

A histone H1.3 that is encoded in the genome of human.


H12_HUMAN Histone H1.2 (sprot)

A histone H1.2 that is encoded in the genome of human.


CTLA4_HUMAN Cytotoxic T-lymphocyte protein 4 (sprot)

A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of human.


ZN823_HUMAN Zinc finger protein 823 (sprot)

A zinc finger protein 823 that is encoded in the genome of human.


EPCAM_HUMAN Epithelial cell adhesion molecule (sprot)

An epithelial cell adhesion molecule that is encoded in the genome of human.


NCPR_HUMAN NADPH--cytochrome P450 reductase (sprot)

An NADPH--cytochrome P450 reductase that is encoded in the genome of human.


NADPH-hemoprotein reductase activity

Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.


electron transport chain

A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.


positive regulation of monooxygenase activity

Any process that activates or increases the activity of a monooxygenase.


cellular organofluorine metabolic process

The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells.


BGAT_HUMAN Histo-blood group ABO system transferase (sprot)

A histo-blood group ABO system transferase that is encoded in the genome of human.


Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.


DPEP1_HUMAN Dipeptidase 1 (sprot)

A dipeptidase 1 that is encoded in the genome of human.


beta-lactamase activity

Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid.


dipeptidase activity

Catalysis of the hydrolysis of a dipeptide.


modified amino acid binding

Binding to a modified amino acid.


antibiotic metabolic process

The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.


homocysteine metabolic process

The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.


lactam catabolic process

The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.


leukotriene D4 catabolic process

The chemical reactions and pathways resulting in the breakdown of leukotriene D4.


EPB42_HUMAN Protein 4.2 (sprot)

A protein 4.2 that is encoded in the genome of human.


MGMT_HUMAN Methylated-DNA--protein-cysteine methyltransferase (sprot)

A methylated-DNA--protein-cysteine methyltransferase that is encoded in the genome of human.


DNA-methyltransferase activity

Catalysis of the transfer of a methyl group to a DNA molecule.


DNA dealkylation involved in DNA repair

The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).


PRLR_HUMAN Prolactin receptor (sprot)

A prolactin receptor that is encoded in the genome of human.


prolactin receptor activity

Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


TSHR_HUMAN Thyrotropin receptor (sprot)

A thyrotropin receptor that is encoded in the genome of human.


thyroid-stimulating hormone receptor activity

Combining with thyroid-stimulating hormone to initiate a change in cell activity.


thyroid-stimulating hormone signaling pathway

A G protein-coupled receptor signaling pathway initiated by thyroid-stimulating hormone (thyrotropin) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


cellular response to glycoprotein

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.


cellular response to thyrotropin-releasing hormone

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


PDE6A_HUMAN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (sprot)

A rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha that is encoded in the genome of human.


NEC2_HUMAN Neuroendocrine convertase 2 (sprot)

A neuroendocrine convertase 2 that is encoded in the genome of human.


islet amyloid polypeptide processing

The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP).


GBB3_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (sprot)

A guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 that is encoded in the genome of human.


regulation of triglyceride metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.


regulation of phospholipid metabolic process

Any process that modulates the frequency, rate or extent of phospholipid metabolic process.


LYAM2_HUMAN E-selectin (sprot)

An E-selectin that is encoded in the genome of human.


actin filament-based process

Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.


FER_HUMAN Tyrosine-protein kinase Fer (sprot)

A tyrosine-protein kinase Fer that is encoded in the genome of human.


regulation of lamellipodium assembly

Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.


response to platelet-derived growth factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.


adherens junction disassembly

The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.


AT2A2_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (sprot)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 that is encoded in the genome of human.


P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential.


ER-nucleus signaling pathway

The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.


regulation of cardiac muscle cell action potential involved in regulation of contraction

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction.


regulation of calcium ion-dependent exocytosis of neurotransmitter

Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter.


calcium ion transport from cytosol to endoplasmic reticulum

The directed movement of calcium ion from cytosol to endoplasmic reticulum.


CL3L1_HUMAN C-C motif chemokine 3-like 1 (sprot)

A C-C motif chemokine 3-like 1 that is encoded in the genome of human.


UD2B7_HUMAN UDP-glucuronosyltransferase 2B7 (sprot)

A UDP-glucuronosyltransferase 2B7 that is encoded in the genome of human.


CD36_HUMAN Platelet glycoprotein 4 (sprot)

A platelet glycoprotein 4 that is encoded in the genome of human.


short-chain fatty acid transmembrane transporter activity

Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons.


lipoteichoic acid immune receptor activity

Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response.


oxidised low-density lipoprotein particle receptor activity

Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis.


short-chain fatty acid transport

The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons.


response to linoleic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus.


cellular response to hydroperoxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.


regulation of action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


oxidised low-density lipoprotein particle clearance

The process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


lipid transport across blood-brain barrier

The directed movement of lipid molecules passing through the blood-brain barrier.


ANFB_HUMAN Natriuretic peptides B (sprot)

A natriuretic peptides B that is encoded in the genome of human.


diuretic hormone activity

The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion.


CBPE_HUMAN Carboxypeptidase E (sprot)

A carboxypeptidase E that is encoded in the genome of human.


cardiac left ventricle morphogenesis

The process in which the left cardiac ventricle is generated and organized.


IL7RA_HUMAN Interleukin-7 receptor subunit alpha (sprot)

An interleukin-7 receptor subunit alpha that is encoded in the genome of human.


interleukin-7 receptor activity

Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


regulation of DNA recombination

Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.


The series of molecular signals initiated by interleukin-7 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


PLCG2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (sprot)

A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 that is encoded in the genome of human.


phospholipase C activity

Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.


follicular B cell differentiation

The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.


inositol trisphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.


cellular response to lipid

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.


cellular response to lectin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties.


FAAA_HUMAN Fumarylacetoacetase (sprot)

A fumarylacetoacetase that is encoded in the genome of human.


STMN1_HUMAN Stathmin (sprot)

A stathmin that is encoded in the genome of human.


YBOX3_HUMAN Y-box-binding protein 3 (sprot)

A Y-box-binding protein 3 that is encoded in the genome of human.


ZFX_HUMAN Zinc finger X-chromosomal protein (sprot)

A zinc finger X-chromosomal protein that is encoded in the genome of human.


parental behavior

A reproductive behavior in which a parent cares for and rears offspring.


ZNF12_HUMAN Zinc finger protein 12 (sprot)

A zinc finger protein 12 that is encoded in the genome of human.


ZNF14_HUMAN Zinc finger protein 14 (sprot)

A zinc finger protein 14 that is encoded in the genome of human.


ZN708_HUMAN Zinc finger protein 708 (sprot)

A zinc finger protein 708 that is encoded in the genome of human.


ZNF16_HUMAN Zinc finger protein 16 (sprot)

A zinc finger protein 16 that is encoded in the genome of human.


positive regulation of megakaryocyte differentiation

Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.


cellular response to sodium dodecyl sulfate

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus.


positive regulation of cell cycle phase transition

Any process that activates or increases the frequency, rate or extent of cell cycle phase transition.


ZNF17_HUMAN Zinc finger protein 17 (sprot)

A zinc finger protein 17 that is encoded in the genome of human.


ZNF18_HUMAN Zinc finger protein 18 (sprot)

A zinc finger protein 18 that is encoded in the genome of human.


ZNF19_HUMAN Zinc finger protein 19 (sprot)

A zinc finger protein 19 that is encoded in the genome of human.


ZNF20_HUMAN Zinc finger protein 20 (sprot)

A zinc finger protein 20 that is encoded in the genome of human.


ZN182_HUMAN Zinc finger protein 182 (sprot)

A zinc finger protein 182 that is encoded in the genome of human.


ZNF22_HUMAN Zinc finger protein 22 (sprot)

A zinc finger protein 22 that is encoded in the genome of human.


ZNF23_HUMAN Zinc finger protein 23 (sprot)

A zinc finger protein 23 that is encoded in the genome of human.


ZNF24_HUMAN Zinc finger protein 24 (sprot)

A zinc finger protein 24 that is encoded in the genome of human.


ZKSC1_HUMAN Zinc finger protein with KRAB and SCAN domains 1 (sprot)

A zinc finger protein with KRAB and SCAN domains 1 that is encoded in the genome of human.


ZNF25_HUMAN Zinc finger protein 25 (sprot)

A zinc finger protein 25 that is encoded in the genome of human.


ZNF26_HUMAN Zinc finger protein 26 (sprot)

A zinc finger protein 26 that is encoded in the genome of human.


ZN37A_HUMAN Zinc finger protein 37A (sprot)

A zinc finger protein 37A that is encoded in the genome of human.


ZNF28_HUMAN Zinc finger protein 28 (sprot)

A zinc finger protein 28 that is encoded in the genome of human.


ZNF3_HUMAN Zinc finger protein 3 (sprot)

A zinc finger protein 3 that is encoded in the genome of human.


ZNF43_HUMAN Zinc finger protein 43 (sprot)

A zinc finger protein 43 that is encoded in the genome of human.


ZNF30_HUMAN Zinc finger protein 30 (sprot)

A zinc finger protein 30 that is encoded in the genome of human.


ZSC20_HUMAN Zinc finger and SCAN domain-containing protein 20 (sprot)

A zinc finger and SCAN domain-containing protein 20 that is encoded in the genome of human.


ZNF32_HUMAN Zinc finger protein 32 (sprot)

A zinc finger protein 32 that is encoded in the genome of human.


An alpha-N-acetylgalactosaminidase that is encoded in the genome of human.


Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides.


HSP76_HUMAN Heat shock 70 kDa protein 6 (sprot)

A heat shock 70 kDa protein 6 that is encoded in the genome of human.


RHOQ_HUMAN Rho-related GTP-binding protein RhoQ (sprot)

A Rho-related GTP-binding protein RhoQ that is encoded in the genome of human.


GBD domain binding

Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.


HMGA1_HUMAN High mobility group protein HMG-I/HMG-Y (sprot)

A high mobility group protein HMG-I/HMG-Y that is encoded in the genome of human.


A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes.


ZNF7_HUMAN Zinc finger protein 7 (sprot)

A zinc finger protein 7 that is encoded in the genome of human.


ZNF8_HUMAN Zinc finger protein 8 (sprot)

A zinc finger protein 8 that is encoded in the genome of human.


TMM11_HUMAN Transmembrane protein 11, mitochondrial (sprot)

A transmembrane protein 11, mitochondrial that is encoded in the genome of human.


AATC_HUMAN Aspartate aminotransferase, cytoplasmic (sprot)

An aspartate aminotransferase, cytoplasmic that is encoded in the genome of human.


Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine.


L-cysteine transaminase activity

Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.


INAR1_HUMAN Interferon alpha/beta receptor 1 (sprot)

An interferon-alpha/beta receptor alpha chain that is encoded in the genome of human.


type I interferon receptor activity

Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.


type I interferon binding

Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.


BPI_HUMAN Bactericidal permeability-increasing protein (sprot)

A bactericidal permeability-increasing protein that is encoded in the genome of human.


negative regulation of macrophage activation

Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.


KPCA_HUMAN Protein kinase C alpha type (sprot)

A protein kinase C alpha type that is encoded in the genome of human.


positive regulation of angiotensin-activated signaling pathway

Any process that activates or increases the frequency, rate or extent of the angiotensin-activated signaling pathway.


JUNB_HUMAN Transcription factor JunB (sprot)

A transcription factor JunB that is encoded in the genome of human.


regulation of T-helper 17 cell differentiation

Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation.


ITA2_HUMAN Integrin alpha-2 (sprot)

An integrin alpha-2 that is encoded in the genome of human.


collagen receptor activity

Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


substrate-dependent cell migration

The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.


hypotonic response

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.


positive regulation of cell projection organization

Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.


positive regulation of transmission of nerve impulse

Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.


CXA1_HUMAN Gap junction alpha-1 protein (sprot)

A gap junction alpha-1 protein that is encoded in the genome of human.


gap junction hemi-channel activity

A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction.


gap junction channel activity involved in cardiac conduction electrical coupling

A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


atrial ventricular junction remodeling

The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle.


cell communication by chemical coupling

The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels.


negative regulation of gonadotropin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin.


positive regulation of striated muscle tissue development

Any process that activates or increases the frequency, rate or extent of striated muscle development.


milk ejection reflex

A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness.


cellular response to pH

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.


positive regulation of morphogenesis of an epithelium

Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium.


positive regulation of mesodermal cell differentiation

Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation.


connexin complex

An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.


ANPRC_HUMAN Atrial natriuretic peptide receptor 3 (sprot)

An atrial natriuretic peptide receptor 3 that is encoded in the genome of human.


regulation of osteoblast proliferation

Any process that modulates the frequency, rate or extent of osteoblast proliferation.


ASM_HUMAN Sphingomyelin phosphodiesterase (sprot)

A sphingomyelin phosphodiesterase that is encoded in the genome of human.


phosphatidylcholine phospholipase C activity

Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H+ + phosphocholine.


acid sphingomyelin phosphodiesterase activity

Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in an acidic environment.


sphingomyelin metabolic process

The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.


endolysosome

An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.


UBF1_HUMAN Nucleolar transcription factor 1 (sprot)

A nucleolar transcription factor 1 that is encoded in the genome of human.


RNA polymerase I core promoter sequence-specific DNA binding

Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.


RNA polymerase I cis-regulatory region sequence-specific DNA binding

Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element).


RNA polymerase I general transcription initiation factor activity

A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs.


HXB8_HUMAN Homeobox protein Hox-B8 (sprot)

A homeobox protein Hox-B8 that is encoded in the genome of human.


HXB9_HUMAN Homeobox protein Hox-B9 (sprot)

A homeobox protein Hox-B9 that is encoded in the genome of human.


HXB4_HUMAN Homeobox protein Hox-B4 (sprot)

A homeobox protein Hox-B4 that is encoded in the genome of human.


HXB6_HUMAN Homeobox protein Hox-B6 (sprot)

A homeobox protein Hox-B6 that is encoded in the genome of human.


AK1C4_HUMAN Aldo-keto reductase family 1 member C4 (sprot)

An aldo-keto reductase family 1 member C4 that is encoded in the genome of human.


chlordecone reductase activity

Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + H+ + NADPH.


cellular response to jasmonic acid stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.


JUND_HUMAN Transcription factor JunD (sprot)

A transcription factor JunD that is encoded in the genome of human.


CTRB1_HUMAN Chymotrypsinogen B (sprot)

A chymotrypsinogen B that is encoded in the genome of human.


KCRS_HUMAN Creatine kinase S-type, mitochondrial (sprot)

A creatine kinase S-type, mitochondrial that is encoded in the genome of human.


TAL1_HUMAN T-cell acute lymphocytic leukemia protein 1 (sprot)

A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human.


astrocyte fate commitment

The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte.


hemangioblast cell differentiation

The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages.


regulation of mast cell differentiation

Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.