oligosaccharide-lipid intermediate biosynthetic process

The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation.


PRS54_HUMAN Inactive serine protease 54 (sprot)

An inactive serine protease 54 that is encoded in the genome of human.


ubiquitin-dependent protein catabolic process via the N-end rule pathway

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.


RGF1C_HUMAN Ras-GEF domain-containing family member 1C (sprot)

A Ras-GEF domain-containing family member 1C that is encoded in the genome of human.


HDHD5_HUMAN Haloacid dehalogenase-like hydrolase domain-containing 5 (sprot)

A haloacid dehalogenase-like hydrolase domain-containing 5 that is encoded in the genome of human.


HSFX4_HUMAN Heat shock transcription factor, X-linked member 4 (sprot)

A protein that is a translation product of the HSFX4 gene in human.


DE10B_HUMAN Putative DENN domain-containing protein 10 B (sprot)

A putative DENN domain-containing protein 10 B that is encoded in the genome of human.


sarcosine dehydrogenase activity

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Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.


PAB4L_HUMAN Polyadenylate-binding protein 4-like (sprot)

A polyadenylate-binding protein 4-like that is encoded in the genome of human.


diphthine methylesterase activity

Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol.


RHN2P_HUMAN Putative rhophilin-2-like protein RHPN2P1 (sprot)


post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery

The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.


TSNA1_HUMAN t-SNARE domain-containing protein 1 (sprot)

A t-SNARE domain-containing protein 1 that is encoded in the genome of human.


dense core granule priming

A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking.


intracellular sodium activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification.


DC8L2_HUMAN DDB1- and CUL4-associated factor 8-like protein 2 (sprot)

A DDB1- and CUL4-associated factor 8-like protein 2 that is encoded in the genome of human.


SAM14_HUMAN Sterile alpha motif domain-containing protein 14 (sprot)

A sterile alpha motif domain-containing protein 14 that is encoded in the genome of human.


DPCA2_HUMAN Putative Dresden prostate carcinoma protein 2 (sprot)


ZY11A_HUMAN Protein zyg-11 homolog A (sprot)

A protein zyg-11 homolog A that is encoded in the genome of human.


PAL4G_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4G (sprot)

A peptidyl-prolyl cis-trans isomerase A-like 4G that is encoded in the genome of human.


H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH.


MANS4_HUMAN MANSC domain-containing protein 4 (sprot)

A MANSC domain-containing protein 4 that is encoded in the genome of human.


cytotoxic T cell differentiation

The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.


SEM3D_HUMAN Semaphorin-3D (sprot)

A semaphorin-3D that is encoded in the genome of human.


GBG14_HUMAN Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 (sprot)


CPHL2_HUMAN Cytoplasmic polyadenylated homeobox-like protein 2 (sprot)

A protein that is a translation product of the CPHXL2 gene in human.


A0A0G2JLM5_HUMAN Killer cell immunoglobulin-like receptor 2DS5 (trembl)


GID complex

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A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species.


transport along microtubule

The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.


MWP complex

A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin.


UBE3B_HUMAN Ubiquitin-protein ligase E3B (sprot)

A ubiquitin-protein ligase E3B that is encoded in the genome of human.


SYT15_HUMAN Synaptotagmin-15 (sprot)

A synaptotagmin-15 that is encoded in the genome of human.


A0A0G2JQ47_HUMAN Killer cell immunoglobulin-like receptor 2DS1 (trembl)


MOXD2_HUMAN Putative DBH-like monooxygenase protein 2 (sprot)


JUN kinase phosphatase activity

Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.


A0A0G2JNF4_HUMAN Killer cell immunoglobulin-like receptor, two Ig domains pseudogene 1 (trembl)


SPD14_HUMAN Putative speedy protein E14 (sprot)


MS4A5_HUMAN Membrane-spanning 4-domains subfamily A member 5 (sprot)

A membrane-spanning 4-domains subfamily A member 5 that is encoded in the genome of human.


synaptic vesicle budding from presynaptic endocytic zone membrane

Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle.


transport

The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.


intracellular cyclic nucleotide activated cation channel complex

A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts.


DNA strand elongation involved in mitotic DNA replication

Any DNA strand elongation involved in mitotic cell cycle DNA replication.


putative ubiquitin carboxyl-terminal hydrolase 41 (human)

A putative ubiquitin carboxyl-terminal hydrolase 41 that is encoded in the genome of human.


LRC43_HUMAN Leucine-rich repeat-containing protein 43 (sprot)

A leucine-rich repeat-containing protein 43 that is encoded in the genome of human.


neurotransmitter receptor transport postsynaptic membrane to endosome

Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome.


CRGN_HUMAN Gamma-crystallin N (sprot)

A gamma-crystallin N that is encoded in the genome of human.


RNA polymerase III activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


MRGX4_HUMAN Mas-related G-protein coupled receptor member X4 (sprot)

A Mas-related G-protein coupled receptor X4 that is encoded in the genome of human.


oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water.


A0A075B6H5_HUMAN T cell receptor beta variable 20/OR9-2 (non-functional) (Fragment) (trembl)


positive regulation of glutamate-cysteine ligase activity

Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.


muscle cell fate specification

The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


CDP-glycerol diphosphatase activity

Catalysis of the reaction: CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H+.


PRT1B_HUMAN Proline rich transmembrane protein 1B (sprot)

A protein that is a translation product of the PRRT1B gene in human.


FR1L4_HUMAN Fer-1-like protein 4 (sprot)

A Fer-1-like protein 4 that is encoded in the genome of human.


positive regulation of somatostatin secretion

Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


transcription regulator activity

A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.


A0A0G2JN01_HUMAN Killer cell immunoglobulin-like receptor, three Ig domains pseudogene 1 (trembl)


MB3LB_HUMAN Methyl-CpG-binding domain protein 3-like 2B (sprot)

A protein that is a translation product of the MBD3L2B gene in human.


tRNA-specific adenosine-34 deaminase activity

Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule.


D-tyrosyl-tRNA(Tyr) deacylase activity

Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA.


VAS1L_HUMAN V-type proton ATPase subunit S1-like protein (sprot)

A V-type proton ATPase subunit S1-like protein that is encoded in the genome of human.


site of polarized growth

Any part of a cell where non-isotropic growth takes place.


putrescine binding

Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.


LRRC2_HUMAN Leucine-rich repeat-containing protein 2 (sprot)

A leucine-rich repeat-containing protein 2 that is encoded in the genome of human.


ME15P_HUMAN Putative methyltransferase-like protein 15P1 (sprot)


peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine.


double-strand break repair via break-induced replication

The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.


GOG8S_HUMAN Golgin subfamily A member 8S (sprot)

A protein that is a translation product of the GOLGA8S gene in human.


D19L4_HUMAN Probable C-mannosyltransferase DPY19L4 (sprot)

A protein dpy-19 4 that is encoded in the genome of human.


RGPD5_HUMAN RANBP2-like and GRIP domain-containing protein 5/6 (sprot)

A RANBP2-like and GRIP domain-containing protein 5/6 that is encoded in the genome of human.


MB3L5_HUMAN Putative methyl-CpG-binding domain protein 3-like 5 (sprot)


PAL4E_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4E (sprot)

A protein that is a translation product of the PPIAL4E gene in human.


response to oxygen levels

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.


DNA replication preinitiation complex

A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.


SMTL2_HUMAN Smoothelin-like protein 2 (sprot)

A smoothelin-like protein 2 that is encoded in the genome of human.


proteasome storage granule

An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state.


LRC63_HUMAN Leucine-rich repeat-containing protein 63 (sprot)

A leucine-rich repeat-containing protein 63 that is encoded in the genome of human.


GRTP1_HUMAN Growth hormone-regulated TBC protein 1 (sprot)

A growth hormone-regulated TBC protein 1 that is encoded in the genome of human.


monosaccharide transmembrane transport

The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


rRNA acetylation involved in maturation of SSU-rRNA

Any rRNA acetylation that is involved in maturation of SSU-rRNA.


mitotic DNA replication initiation

Any DNA replication initiation involved in mitotic cell cycle DNA replication.


phagolysosome assembly involved in apoptotic cell clearance

The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance.


inositol tetrakisphosphate kinase activity

Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP.


A0A0G2JP03_HUMAN Killer cell immunoglobulin-like receptor 3DL3 (Fragment) (trembl)


Lsm1-7-Pat1 complex

A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway.


RGPD4_HUMAN RanBP2-like and GRIP domain-containing protein 4 (sprot)

A RanBP2-like and GRIP domain-containing protein 4 that is encoded in the genome of human.


N-terminal peptidyl-serine methylation

The methylation of the N-terminal serine of proteins.


DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates

Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA).


gonadotropin-releasing hormone receptor activity

Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


regulation of translation at presynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.


T11X2_HUMAN T-complex protein 11 X-linked protein 2 (sprot)

A protein that is a translation product of the TCP11X2 gene in human.


vacuolar protein processing

Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.


LRC58_HUMAN Leucine-rich repeat-containing protein 58 (sprot)

A leucine-rich repeat-containing protein 58 that is encoded in the genome of human.


short-chain carboxylesterase activity

Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.


TBC12_HUMAN TBC1 domain family member 12 (sprot)

A TBC1 domain family member 12 that is encoded in the genome of human.


amino acid kinase activity

Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate.


siRNA 3'-end processing

The process of forming the mature 3' end of a siRNA molecule.


ARH37_HUMAN Rho guanine nucleotide exchange factor 37 (sprot)

A Rho guanine nucleotide exchange factor 37 that is encoded in the genome of human.


phosphorus-oxygen lyase activity

Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


post-mRNA release spliceosomal complex

A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac.


pyrimidine nucleoside transport

The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


positive regulation of G2/MI transition of meiotic cell cycle

Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.


KHDCL_HUMAN Putative KHDC1-like protein (sprot)


RS10L_HUMAN Putative ribosomal protein eS10-like (sprot)


KI2LB_HUMAN Killer cell immunoglobulin-like receptor 2DL5B (sprot)

A killer cell immunoglobulin-like receptor 2DL5B that is encoded in the genome of human.


INY2B_HUMAN Protein INSYN2B (sprot)

A protein INSYN2B that is encoded in the genome of human.


SHSA8_HUMAN Protein shisa-8 (sprot)

A protein shisa-8 that is encoded in the genome of human.


PTG3L_HUMAN Putative protein PTGES3L (sprot)

A protein PTGES3L that is encoded in the genome of human.


glycine receptor clustering

The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane.


biological process involved in interspecies interaction between organisms

Any process evolved to enable an interaction with an organism of a different species.


PRS48_HUMAN Serine protease 48 (sprot)

A serine protease 48 that is encoded in the genome of human.


KNCN_HUMAN Kinocilin (sprot)

A kinocilin that is encoded in the genome of human.


CTGEF_HUMAN cTAGE family member 15 (sprot)

A protein that is a translation product of the CTAGE15 gene in human.


A0A376A8Z9_HUMAN KIR2DS5 protein (trembl)


Pwp2p-containing subcomplex of 90S preribosome

A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.


valine biosynthetic process

The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.


tRNA-type intron splice site recognition and cleavage

RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.


exocyst localization

Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.


D-xylose 1-dehydrogenase (NADP+) activity

Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + H+ + NADPH.


SPA13_HUMAN Putative serpin A13 (sprot)

A putative serpin A13 that is encoded in the genome of human.


snRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.


acetolactate synthase complex

A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate.


U4 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U4 snRNA molecule.


SPD15_HUMAN Putative speedy protein E15 (sprot)


GOG8J_HUMAN Golgin subfamily A member 8J (sprot)

A golgin subfamily A member 8J that is encoded in the genome of human.


SPD17_HUMAN Putative speedy protein E17 (sprot)


gonadotropin-releasing hormone receptor binding

Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.


NALF2_HUMAN NALCN channel auxiliary factor 2 (sprot)

A NALCN channel auxiliary factor 2 that is encoded in the genome of human.


QCR6L_HUMAN Cytochrome b-c1 complex subunit 6-like, mitochondrial (sprot)

A protein that is a translation product of the UQCRHL gene in human.


urotensin II receptor activity

Combining with urotensin II to initiate a change in cell activity.


fructosamine metabolic process

The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.


LR14B_HUMAN Leucine-rich repeat-containing protein 14B (sprot)

A leucine-rich repeat-containing protein 14B that is encoded in the genome of human.


negative regulation of gastrin-induced gastric acid secretion

Any process that stops, prevents or reduces the frequency, rate or extent of gastrin-induced gastric acid secretion.


PRS29_HUMAN Putative serine protease 29 (sprot)


INT6L_HUMAN Integrator complex subunit 6-like (sprot)

An integrator complex subunit 6-like that is encoded in the genome of human.


transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.


cerebellar granular layer maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.


CAN13_HUMAN Calpain-13 (sprot)

A calpain-13 that is encoded in the genome of human.


nuclear polyadenylation-dependent snRNA catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA.


CPHXL_HUMAN Cytoplasmic polyadenylated homeobox-like protein (sprot)

A protein that is a translation product of the CPHXL gene in human.


soluble NSF attachment protein activity

Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex.


regulation of postsynaptic neurotransmitter receptor activity

Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.


M1BL1_HUMAN Metallothionein 1H-like protein 1 (sprot)

A protein that is a translation product of the MT1HL1 gene in human.


RNA lariat debranching enzyme activator activity

Binds to and increases the activity of an RNA lariat debranching enzyme.


thiosulfate transmembrane transporter activity

Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other.


monounsaturated fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid.


ribose phosphate metabolic process

The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar.


lipoic acid binding

Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid.


nucleotide-excision repair factor 2 complex

One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.


Atg8 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond.


spliceosomal tri-snRNP complex

A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP.


A0A0G2JLQ3_HUMAN Killer cell immunoglobulin-like receptor (trembl)


gluconokinase activity

Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+.


imidazolonepropionase activity

Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+.


MAGC3_HUMAN Melanoma-associated antigen C3 (sprot)

A melanoma-associated antigen C3 that is encoded in the genome of human.


mitotic DNA damage checkpoint signaling

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A signal transduction process involved in mitotic DNA damage checkpoint.


fatty-acyl-CoA synthase activity

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.


CTGE8_HUMAN cTAGE family member 8 (sprot)

A cTAGE family member 8 that is encoded in the genome of human.


pre-mRNA 5'-splice site binding

Binding to a pre-mRNA 5' splice site sequence.


PYY3_HUMAN Putative peptide YY-3 (sprot)


CF052_HUMAN Putative uncharacterized protein C6orf52 (sprot)

A protein that is a translation product of the C6orf52 gene in human.


riboflavin binding

Binding to riboflavin.


MROH6_HUMAN Maestro heat-like repeat-containing protein family member 6 (sprot)

A protein that is a translation product of the MROH6 gene in human.


G protein-coupled glutamate receptor binding

Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor).


UAP1L_HUMAN UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (sprot)

A UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 that is encoded in the genome of human.


Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.


LRC28_HUMAN Leucine-rich repeat-containing protein 28 (sprot)

A leucine-rich repeat-containing protein 28 that is encoded in the genome of human.


AG1L2_HUMAN Putative glycosyltransferase ALG1L2 (sprot)

A putative glycosyltransferase ALG1L2 that is encoded in the genome of human.


S36A3_HUMAN Proton-coupled amino acid transporter 3 (sprot)

A proton-coupled amino acid transporter 3 that is encoded in the genome of human.


CCYL3_HUMAN Putative cyclin-Y-like protein 3 (sprot)

A putative cyclin-Y-like protein 3 that is encoded in the genome of human.


nuclear polyadenylation-dependent snoRNA catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA.


tRNA wobble position uridine thiolation

The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.


guanine transport

The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


TLDC2_HUMAN TLD domain-containing protein 2 (sprot)

A TLD domain-containing protein 2 that is encoded in the genome of human.


U12 snRNA binding

Binding to a U12 small nuclear RNA (U12 snRNA).


SNUFL_HUMAN Putative SNURF-like protein (sprot)


SEML_HUMAN Putative protein SEM1, isoform 2 (sprot)


MSD1_HUMAN Myb/SANT-like DNA-binding domain-containing protein 1 (sprot)

A Myb/SANT-like DNA-binding domain-containing protein 1 that is encoded in the genome of human.


WF10A_HUMAN WAP four-disulfide core domain protein 10A (sprot)

A WAP four-disulfide core domain protein 10A that is encoded in the genome of human.


WDR5B_HUMAN WD repeat-containing protein 5B (sprot)

A WD repeat-containing protein 5B that is encoded in the genome of human.


ribose phosphate diphosphokinase complex

A protein complex having ribose phosphate diphosphokinase activity.


nucleophagy

A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded.


deoxyribonuclease I activity

Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products.


IgG receptor activity

Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


VSI10_HUMAN V-set and immunoglobulin domain-containing protein 10 (sprot)

A V-set and immunoglobulin domain-containing protein 10 that is encoded in the genome of human.


SATL1_HUMAN Spermidine/spermine N(1)-acetyltransferase-like protein 1 (sprot)

A spermidine/spermine N(1)-acetyltransferase-like protein 1 that is encoded in the genome of human.


spermidine binding

Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane.


HIR complex

A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p.


SCML1_HUMAN Sex comb on midleg-like protein 1 (sprot)

A sex comb on midleg-like protein 1 that is encoded in the genome of human.


glutathione-disulfide reductase (NADP) activity

Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.


m-AAA complex

Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria.


autophagy of peroxisome

The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions.


SEM6C_HUMAN Semaphorin-6C (sprot)

A semaphorin-6C that is encoded in the genome of human.


meiotic chromosome separation

The process in which chromosomes are physically detached from each other during meiosis.


MAGBG_HUMAN Melanoma-associated antigen B16 (sprot)

A melanoma-associated antigen B16 that is encoded in the genome of human.


The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


PMIS2_HUMAN Transmembrane protein PMIS2 (sprot)

A protein that is a translation product of the PMIS2 gene in human.


diadenosine pentaphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate.


MCAF2_HUMAN Activating transcription factor 7-interacting protein 2 (sprot)

An activating transcription factor 7-interacting protein 2 that is encoded in the genome of human.


meiotic DNA double-strand break processing

The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis.


spine apparatus assembly

The aggregation, arrangement and bonding together of a set of components to form a spine apparatus.


response to 11-deoxycorticosterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus.


A0A1W2PN81_HUMAN Neuronal acetylcholine receptor subunit alpha-7 (trembl)


regulation of muscle system process

Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.


plasma membrane signaling receptor complex

Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.


neuromedin B receptor binding

Binding to a neuromedin B receptor.


F135B_HUMAN Protein FAM135B (sprot)

A protein FAM135B that is encoded in the genome of human.


plasmacytoid dendritic cell cytokine production

Any process that contributes to cytokine production by a plasmacytoid dendritic cell.


sodium-dependent multivitamin transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate.


F220P_HUMAN Putative protein FAM220BP (sprot)


ARRD5_HUMAN Arrestin domain-containing protein 5 (sprot)

An arrestin domain-containing protein 5 that is encoded in the genome of human.


extrinsic component of postsynaptic early endosome membrane

The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


N-acetylglucosamine catabolic process

The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.


regulation of skeletal muscle cell proliferation

Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.


C2D2B_HUMAN Protein CC2D2B (sprot)

A protein CC2D2B that is encoded in the genome of human.


arginine catabolic process to ornithine

The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.


protein methylesterase activity

Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol.


MROH1_HUMAN Maestro heat-like repeat-containing protein family member 1 (sprot)

A maestro heat-like repeat-containing protein family member 1 that is encoded in the genome of human.


phosphatidylinositol 3-kinase complex, class III, type II

A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.


glycine biosynthetic process from serine

The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine.


Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.


termination of RNA polymerase III transcription

A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues.


sulfite oxidase activity

Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate.


D19P2_HUMAN Putative C-mannosyltransferase DPY19L2P2 (sprot)

A protein dpy-19 2-like 2 that is encoded in the genome of human.


germ-line stem cell division

The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.


K1755_HUMAN Uncharacterized protein KIAA1755 (sprot)

An uncharacterized protein KIAA1755 that is encoded in the genome of human.


GOG8R_HUMAN Golgin subfamily A member 8R (sprot)

A protein that is a translation product of the GOLGA8R gene in human.


endoplasmic reticulum mannose trimming

Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC).


ANR42_HUMAN Ankyrin repeat domain-containing protein 42 (sprot)

An ankyrin repeat domain-containing protein 42 that is encoded in the genome of human.


actin filament debranching

An actin filament severing process that results in the removal of actin filament branches specifically at the branch points.


SIRB2_HUMAN Signal-regulatory protein beta-2 (sprot)

A signal-regulatory protein beta-2 that is encoded in the genome of human.


Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.


regulation of protein localization to membrane

Any process that modulates the frequency, rate or extent of protein localization to membrane.


CCR4-NOT core complex

The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.


TM88B_HUMAN Transmembrane protein 88B (sprot)

A transmembrane protein 88B that is encoded in the genome of human.


late endosome to vacuole transport via multivesicular body sorting pathway

The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole.


organic acid binding

Binding to an organic acid, any acidic compound containing carbon in covalent linkage.


CTGE9_HUMAN cTAGE family member 9 (sprot)

A cTAGE family member 9 that is encoded in the genome of human.


AN32C_HUMAN Putative uncharacterized protein ANP32CP (sprot)

An acidic leucine-rich nuclear phosphoprotein 32 family member C that is encoded in the genome of human.


UFM1 transferase activity

Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages.


MRO2A_HUMAN Maestro heat-like repeat-containing protein family member 2A (sprot)

A maestro heat-like repeat-containing protein family member 2A that is encoded in the genome of human.


SP201_HUMAN Transcription factor SPT20 homolog-like 1 (sprot)

A protein FAM48B1 that is encoded in the genome of human.


tRNA methylthiolation

The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule.


CHCH9_HUMAN Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (sprot)


regulatory ncRNA-mediated heterochromatin formation

A heterochromatin formation-based gene silencing process mediated by a regulatory non-coding RNA molecule that occur before the beginnning of trancription.


cytoplasmic U snRNP body

A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies.


RMXL2_HUMAN RNA-binding motif protein, X-linked-like-2 (sprot)

An RNA-binding motif protein, X-linked-like-2 that is encoded in the genome of human.


DC8L1_HUMAN DDB1- and CUL4-associated factor 8-like protein 1 (sprot)

A DDB1- and CUL4-associated factor 8-like protein 1 that is encoded in the genome of human.


MEI1_HUMAN Meiosis inhibitor protein 1 (sprot)

A meiosis inhibitor protein 1 that is encoded in the genome of human.


P12L2_HUMAN POM121-like protein 2 (sprot)

A POM121-like protein 2 that is encoded in the genome of human.


DR4L1_HUMAN Putative dehydrogenase/reductase SDR family member 4-like 1 (sprot)


ANHX_HUMAN Anomalous homeobox protein (sprot)

An anomalous homeobox protein that is encoded in the genome of human.


nucleoside phosphate metabolic process

The chemical reactions and pathways involving any phosphorylated nucleoside.


SE1L2_HUMAN Protein sel-1 homolog 2 (sprot)

A protein sel-1 homolog 2 that is encoded in the genome of human.


OCEL1_HUMAN Occludin/ELL domain-containing protein 1 (sprot)

An occludin/ELL domain-containing protein 1 that is encoded in the genome of human.


mitochondrial proton-transporting ATP synthase, stator stalk

One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.


ARH38_HUMAN Rho guanine nucleotide exchange factor 38 (sprot)

A Rho guanine nucleotide exchange factor 38 that is encoded in the genome of human.


S-formylglutathione hydrolase activity

Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+.


The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate.


diphosphoinositol polyphosphate metabolic process

The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached.


septin ring

A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form.


RGPD2_HUMAN RANBP2-like and GRIP domain-containing protein 2 (sprot)

A RANBP2-like and GRIP domain-containing protein 2 that is encoded in the genome of human.


HEAT4_HUMAN HEAT repeat-containing protein 4 (sprot)

A HEAT repeat-containing protein 4 that is encoded in the genome of human.


exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.


CCNJ_HUMAN Cyclin-J (sprot)

A cyclin-J that is encoded in the genome of human.


D-alanine transport

The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


MFS6L_HUMAN Major facilitator superfamily domain-containing protein 6-like (sprot)

A major facilitator superfamily domain-containing protein 6-like that is encoded in the genome of human.


spindle elongation

The cell cycle process in which the distance is lengthened between poles of the spindle.


perisynaptic extracellular matrix

The portion of the extracellular matrix that lies within the perisynaptic space.


KCNT1_HUMAN Potassium channel subfamily T member 1 (sprot)

A potassium channel subfamily T member 1 that is encoded in the genome of human.


TPBGL_HUMAN Trophoblast glycoprotein-like (sprot)

A trophoblast glycoprotein-like that is encoded in the genome of human.


XKR9_HUMAN XK-related protein 9 (sprot)

An XK-related protein 9 that is encoded in the genome of human.


secondary metabolic process

The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.


NAD(P)+ transhydrogenase activity

Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.


pyrimidine nucleobase biosynthetic process

The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


UTP-C complex

A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p.


generation of catalytic spliceosome for second transesterification step

Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing.


SPA11_HUMAN Serpin A11 (sprot)

A serpin A11 that is encoded in the genome of human.


dystroglycan complex

A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.


nuclear pore central transport channel

The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.


prostacyclin receptor activity

Combining with prostacyclin (PGI(2)) to initiate a change in cell activity.


structural constituent of postsynaptic intermediate filament cytoskeleton

The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton.


MDH1B_HUMAN Putative malate dehydrogenase 1B (sprot)

A putative malate dehydrogenase 1B that is encoded in the genome of human.


RGPD1_HUMAN RANBP2-like and GRIP domain-containing protein 1 (sprot)

A RANBP2-like and GRIP domain-containing protein 1 that is encoded in the genome of human.


TT39C_HUMAN Tetratricopeptide repeat protein 39C (sprot)

A tetratricopeptide repeat protein 39C that is encoded in the genome of human.


lysine biosynthetic process via aminoadipic acid

The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.


SGE2P_HUMAN Putative SAGE1-like protein (sprot)


septin ring organization

Control of the formation, spatial distribution, and breakdown of the septin ring.


gonadotropin hormone-releasing hormone activity

The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary.


Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.


IT70A_HUMAN Intraflagellar transport protein 70A (sprot)

A tetratricopeptide repeat protein 30A that is encoded in the genome of human.


cargo adaptor activity

Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery.


propionate catabolic process

The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid.


regulation of recycling endosome localization within postsynapse

Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.


GTP cyclohydrolase binding

Binding to a GTP cyclohydrolase.


negative regulation of ribosome biogenesis

Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


T178B_HUMAN Transmembrane protein 178B (sprot)

A transmembrane protein 178B that is encoded in the genome of human.


DJC25_HUMAN DnaJ homolog subfamily C member 25 (sprot)

A DnaJ homolog subfamily C member 25 that is encoded in the genome of human.


histone H3K79 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein.


GOG8N_HUMAN Golgin subfamily A member 8N (sprot)

A protein that is a translation product of the GOLGA8N gene in human.


GOG8K_HUMAN Golgin subfamily A member 8K (sprot)

A protein that is a translation product of the GOLGA8K gene in human.


type 1 melanin-concentrating hormone receptor binding

Binding to a type 1 melanin-concentrating hormone receptor.


DC122_HUMAN DDB1- and CUL4-associated factor 12-like protein 2 (sprot)

A DDB1- and CUL4-associated factor 12-like protein 2 that is encoded in the genome of human.


RRP7B_HUMAN Putative ribosomal RNA-processing protein 7 homolog B (sprot)


T11X1_HUMAN T-complex protein 11 X-linked protein 1 (sprot)

A protein that is a translation product of the TCP11X1 gene in human.


PRS47_HUMAN Putative serine protease 47 (sprot)


SCML4_HUMAN Sex comb on midleg-like protein 4 (sprot)

A sex comb on midleg-like protein 4 that is encoded in the genome of human.


A0A126GWB0_HUMAN Olfactory receptor (trembl)


replication fork protection complex

A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.


nitrate transmembrane transporter activity

Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other.


fast-twitch skeletal muscle fiber contraction

A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability.


norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.


ubiquitin-like protein binding

Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.


TBC26_HUMAN TBC1 domain family member 26 (sprot)

A TBC1 domain family member 26 that is encoded in the genome of human.


DC4L2_HUMAN DDB1- and CUL4-associated factor 4-like protein 2 (sprot)

A DDB1- and CUL4-associated factor 4-like protein 2 that is encoded in the genome of human.


A0A4W9AIG4_HUMAN Olfactory receptor (trembl)


PAL4D_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4D (sprot)

A protein that is a translation product of the PPIAL4D gene in human.


phagophore

A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle.


regulation of ERBB signaling pathway

Any process that modulates the frequency, rate or extent of ERBB signaling pathway.


Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.


polytene chromosome

A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.


Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate.


PAS complex

A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.


HNRC3_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 3 (sprot)

A protein that is a translation product of the HNRNPCL3 gene in human.


negative regulation of G2/MI transition of meiotic cell cycle

Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.


neuropeptide Y receptor binding

Binding to a neuropeptide Y receptor.


Swi5-Swi2 complex

A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching.


octopamine biosynthetic process

The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species.


neurotransmitter receptor transport, postsynaptic endosome to lysosome

The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.


P4R3C_HUMAN Protein PPP4R3C (sprot)

A protein that is a translation product of the PPP4R3C gene in human.


BTNLA_HUMAN Putative butyrophilin-like protein 10 pseudogene (sprot)


meiotic strand invasion involved in reciprocal meiotic recombination

The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.


negative regulation of serine-type peptidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity.


peroxisomal importomer complex

A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners.


muscle attachment

The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).


O-glycan processing, core 1

The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc.


establishment of cell polarity involved in ameboidal cell migration

The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.


CURI complex

A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.


The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.


postsynaptic endocytic zone cytoplasmic component

The cytoplasmic component of the postsynaptic endocytic zone.


M4A10_HUMAN Membrane-spanning 4-domains subfamily A member 10 (sprot)

A membrane-spanning 4-domains subfamily A member 10 that is encoded in the genome of human.


RN3P2_HUMAN Putative RRN3-like protein RRN3P2 (sprot)


nucleotide-sugar metabolic process

The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.


GOG8M_HUMAN Golgin subfamily A member 8M (sprot)

A protein that is a translation product of the GOLGA8M gene in human.


interleukin-8 production

The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


hydroxypyruvate isomerase activity

Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate.


CRCC2_HUMAN Ciliary rootlet coiled-coil protein 2 (sprot)

A ciliary rootlet coiled-coil protein 2 that is encoded in the genome of human.


K1614_HUMAN Uncharacterized protein KIAA1614 (sprot)

A protein that is a translation product of the KIAA1614 gene in human.


protein localization to kinetochore involved in kinetochore assembly

Any protein localization to kinetochore that is involved in kinetochore assembly.


GOG6D_HUMAN Golgin subfamily A member 6D (sprot)

A protein that is a translation product of the GOLGA6D gene in human.


CAST3_HUMAN Putative protein CASTOR3P (sprot)


detoxification of zinc ion

Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion.


pristanoyl-CoA oxidase activity

Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide.


intermediate filament-based process

Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins.


TEX26_HUMAN Testis-expressed protein 26 (sprot)

A testis-expressed protein 26 that is encoded in the genome of human.


GOG8I_HUMAN Putative golgin subfamily A member 8I (sprot)


FRYL_HUMAN Protein furry homolog-like (sprot)

A protein furry-like that is encoded in the genome of human.


GTP 3',8'-cyclase activity

Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.


DUX5_HUMAN Double homeobox protein 5 (sprot)

A double homeobox protein 5 that is encoded in the genome of human.


myosin II filament disassembly

The disassembly of a bipolar filament composed of myosin II molecules.


PAL4H_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4H (sprot)

A protein that is a translation product of the PPIAL4H gene in human.


RAVE complex

A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme.


nuclear mRNA surveillance of mRNA 3'-end processing

The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus.


CEA21_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 21 (sprot)

A carcinoembryonic antigen-related cell adhesion molecule 21 that is encoded in the genome of human.


actin cortical patch localization

Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells.


IQCF5_HUMAN IQ domain-containing protein F5 (sprot)

An IQ domain-containing protein F5 that is encoded in the genome of human.


Seh1-associated complex

A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.


GDP-mannose hydrolase activity

Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate.


cytoskeletal rearrangement involved in phagocytosis, engulfment

The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.


DNA recombinase complex

A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA.


deoxyribonuclease II activity

Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products.


GRIFN_HUMAN Grifin (sprot)

A grifin that is encoded in the genome of human.


meiotic DNA integrity checkpoint signaling

A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.


valyl-tRNA aminoacylation

The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


acetolactate synthase activity

Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.


chemokine production

The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


PRS45_HUMAN Putative serine protease 45 (sprot)

A putative serine protease 45 that is encoded in the genome of human.


structural constituent of presynaptic active zone

The action of a molecule that contributes to the structural integrity of a presynaptic active zone.


LRC69_HUMAN Leucine-rich repeat-containing protein 69 (sprot)

A leucine-rich repeat-containing protein 69 that is encoded in the genome of human.


serine O-acyltransferase activity

Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule.


axonemal basal plate

Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure.


OLFL1_HUMAN Olfactomedin-like protein 1 (sprot)

An olfactomedin-like protein 1 that is encoded in the genome of human.


RNA polymerase II, holoenzyme

A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters.


D-lactate dehydrogenase activity

Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate.


GOG6C_HUMAN Golgin subfamily A member 6C (sprot)

A protein that is a translation product of the GOLGA6C gene in human.


MF2L2_HUMAN Probable guanine nucleotide exchange factor MCF2L2 (sprot)

A probable guanine nucleotide exchange factor MCF2L2 that is encoded in the genome of human.


PDZ1P_HUMAN Putative PDZ domain-containing protein PDZK1P1 (sprot)


cupric reductase activity

Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.


nuclear microtubule

Any microtubule in the nucleus of a cell.


bub1-bub3 complex

Protein complex that associates with the kinetochores.


regulation of regulatory ncRNA processing

Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing.


SERP3_HUMAN Serpin E3 (sprot)

A serpin E3 that is encoded in the genome of human.


Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A).


epinephrine secretion

The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system.


A0A087X1C1_HUMAN Thymosin beta 15B (trembl)


actin-based cell projection

A cell projection supported by an assembly of actin filaments, and which lacks microtubules.


neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol.


folic acid-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.


telomere tethering at nuclear periphery

The process in which a telomere is maintained in a specific location at the nuclear periphery.


MRGRE_HUMAN Mas-related G-protein coupled receptor member E (sprot)

A Mas-related G-protein coupled receptor E that is encoded in the genome of human.


phosphocreatine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase.


Dbf4-dependent protein kinase complex

A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.


U5 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U5 snRNA molecule.


slow-twitch skeletal muscle fiber contraction

A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.


CC191_HUMAN Coiled-coil domain-containing protein 191 (sprot)

A protein that is a translation product of the CCDC191 gene in human.


recombinase activator activity

Binds to and increases the activity of a recombinase.


putrescine biosynthetic process from arginine, using agmatinase

The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step.


nuclear pre-replicative complex

A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.


vitamin A import into cell

The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid.


ACBD4_HUMAN Acyl-CoA-binding domain-containing protein 4 (sprot)

An acyl-CoA-binding domain-containing protein 4 that is encoded in the genome of human.


ubiquinone-6 biosynthetic process

The chemical reactions and pathways resulting in the formation of ubiquinone-6.


polyprenol biosynthetic process

The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.


PAL4F_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4F (sprot)

A protein that is a translation product of the PPIAL4F gene in human.


metabolite repair

A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites.


FR1L5_HUMAN Fer-1-like protein 5 (sprot)

A Fer-1-like protein 5 that is encoded in the genome of human.


RNA polymerase III core binding

Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.


mitotic DNA replication

Any nuclear DNA replication that is involved in a mitotic cell cycle.


D5 dopamine receptor binding

Binding to a D5 dopamine receptor.


TRAPPI protein complex

A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the core subunits of all TRAPP complexes in yeast.


KCP_HUMAN Kielin/chordin-like protein (sprot)

A cysteine-rich motor neuron 2 protein that is encoded in the genome of human.


P3URF_HUMAN PIK3R3 upstream open reading frame protein (sprot)

A PIK3R3 upstream open reading frame protein that is encoded in the genome of human.


tRNA-intron endonuclease activity

Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.


fatty acid synthase activity

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.


CH088_HUMAN Uncharacterized protein C8orf88 (sprot)

A protein that is a translation product of the C8orf88 gene in human.


priRNA 3'-end processing

The process of forming the mature 3' end of a priRNA molecule.


clathrin-dependent synaptic vesicle endocytosis

Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds.


purine-specific nucleoside:sodium symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in).


dUDP biosynthetic process

The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate).


substance P receptor binding

Binding to a substance P receptor.


peptidyl-histidine methylation, to form tele-methylhistidine

The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine).


EX3L4_HUMAN Exocyst complex component 3-like protein 4 (sprot)

An exocyst complex component 3-like protein 4 that is encoded in the genome of human.


leucine-rich repeat-containing protein 29 (human)

A leucine-rich repeat-containing protein 29 that is encoded in the genome of human.


exopolyphosphatase activity

Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.


mu-type opioid receptor binding

Binding to a mu-type opioid receptor.


negative regulation of RNA catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process.


NPS3B_HUMAN Protein NipSnap homolog 3B (sprot)

A protein NipSnap homolog 3B that is encoded in the genome of human.


regulation of plasma membrane sterol distribution

Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane.


striated muscle dense body

A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.


regulation of integrin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.


kainate selective glutamate receptor complex

An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits.


Sec62/Sec63 complex

A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.


A0A0G2JN68_HUMAN Killer cell immunoglobulin-like receptor 2DL5B (trembl)


eRF1 methyltransferase complex

A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p.


response to dehydroepiandrosterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus.


messenger ribonucleoprotein complex

A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.


Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate.


meiotic joint molecule formation

The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.


CCNI2_HUMAN Cyclin-I2 (sprot)

A cyclin-I2 that is encoded in the genome of human.


negative regulation of sequestering of calcium ion

Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


tRNA import into mitochondrion

The process in which a tRNA is transported from the cytosol into the mitochondrial matrix.


Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.


chromosome localization to nuclear envelope involved in homologous chromosome segregation

The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis.


ribonuclease MRP activity

Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.


NBEL1_HUMAN Neurobeachin-like protein 1 (sprot)

A neurobeachin-like protein 1 that is encoded in the genome of human.


telomere localization

Any process in which a telomere is transported to, and/or maintained in, a specific location.


thiosulfate transport

The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


MutLalpha complex

A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.


cone matrix sheath

A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments.


PONL1_HUMAN Podocan-like protein 1 (sprot)

A podocan-like protein 1 that is encoded in the genome of human.


TM9S3_HUMAN Transmembrane 9 superfamily member 3 (sprot)

A transmembrane 9 superfamily member 3 that is encoded in the genome of human.


neural fold bending

The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse.


nucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.


Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.


somatic recombination of immunoglobulin genes involved in immune response

The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.


NUA4L_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 that is encoded in the genome of human.


Ral protein signal transduction

The series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.


NADHX epimerase activity

Catalysis of the reaction: (R)-NADHX = (S)-NADHX.


regulation of arginine metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


U1 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U1 snRNA molecule.


mitochondrial DNA-directed RNA polymerase complex

A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form.


Set3 complex

A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.


group II metabotropic glutamate receptor activity

A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.


positive regulation of anaphase-promoting complex-dependent catabolic process

Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


SG1D4_HUMAN Secretoglobin family 1D member 4 (sprot)

A secretoglobin family 1D member 4 that is encoded in the genome of human.


mitotic cell cycle checkpoint signaling

A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.


transcription open complex formation at RNA polymerase II promoter

Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.


PGBD2_HUMAN PiggyBac transposable element-derived protein 2 (sprot)

A piggyBac transposable element-derived protein 2 that is encoded in the genome of human.


microtubule plus end polymerase

Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers.


interleukin-33 binding

Binding to interleukin-33.


A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces.


LRC27_HUMAN Leucine-rich repeat-containing protein 27 (sprot)

A leucine-rich repeat-containing protein 27 that is encoded in the genome of human.


LHPL7_HUMAN LHFPL tetraspan subfamily member 7 protein (sprot)

An LHFPL tetraspan subfamily member 7 protein that is encoded in the genome of human.


heterotrimeric G-protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex.


tRNA threonylcarbamoyladenosine metabolic process

The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.


PLPR3_HUMAN Phospholipid phosphatase-related protein type 3 (sprot)

A phospholipid phosphatase-related protein type 3 that is encoded in the genome of human.


phosphoglycerate dehydrogenase activity

Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.


The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


parathyroid hormone receptor binding

Binding to a parathyroid hormone receptor.


M4A15_HUMAN Membrane-spanning 4-domains subfamily A member 15 (sprot)

A membrane-spanning 4-domains subfamily A member 15 that is encoded in the genome of human.


cysteinyl leukotriene receptor activity

Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine.


acylphosphatase activity

Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.


maintenance of ER location

Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere.


alpha-amino acid metabolic process

The chemical reactions and pathways involving an alpha-amino acid.


tRNA re-export from nucleus

The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export.


oxytocin receptor activity

Combining with oxytocin to initiate a change in cell activity.


SPE2B_HUMAN Speedy protein E2B (sprot)

A protein that is a translation product of the SPDYE2B gene in human.


sphinganine metabolic process

The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol.


TIGD2_HUMAN Tigger transposable element-derived protein 2 (sprot)

A tigger transposable element-derived protein 2 that is encoded in the genome of human.


sarcosine catabolic process

The chemical reactions and pathways resulting in the breakdown of sarcosine.


translation reinitiation

A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.


A0A0G2JPC4_HUMAN Killer cell immunoglobulin-like receptor (trembl)


acireductone dioxygenase [iron(II)-requiring] activity

Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+.


Golgi vesicle docking

The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane.


CDP biosynthetic process

The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate.


negative regulation of cytoplasmic translational initiation in response to stress

Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.


determination of ventral identity

The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.


nuclear polyadenylation-dependent antisense transcript catabolic process

The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript.


tRNA wobble adenosine to inosine editing

The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine.


negative regulation of gastric acid secretion

Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


nickel cation transmembrane transporter activity

Enables the transfer of nickel (Ni) cations from one side of a membrane to the other.


BT2A3_HUMAN Putative butyrophilin subfamily 2 member A3 (sprot)


NHSL1_HUMAN NHS-like protein 1 (sprot)

An NHS-like protein 1 that is encoded in the genome of human.


Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA.


ACL10_HUMAN Actin-like protein 10 (sprot)

An actin-like protein 10 that is encoded in the genome of human.


establishment of sister chromatid cohesion

The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase.


GOG6B_HUMAN Golgin subfamily A member 6B (sprot)

A protein that is a translation product of the GOLGA6B gene in human.


guanine deaminase activity

Catalysis of the reaction: guanine + H2O = xanthine + NH3.


interleukin-9 binding

Binding to interleukin-9.


sucrose biosynthetic process

The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside.


SNG4_HUMAN Synaptogyrin-4 (sprot)

A synaptogyrin-4 that is encoded in the genome of human.


DMXL1_HUMAN DmX-like protein 1 (sprot)

A DmX-like protein 1 that is encoded in the genome of human.


catenin-TCF7L2 complex

A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.


Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.


CA5BL_HUMAN Putative inactive carbonic anhydrase 5B-like protein (sprot)


NKG2F_HUMAN NKG2-F type II integral membrane protein (sprot)

An NKG2-F type II integral membrane protein that is encoded in the genome of human.


meiotic spindle midzone

The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap.


transcription factor TFIIE complex

A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH.


deoxynucleoside kinase activity

Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate.


regulation of glucosylceramidase activity

Any process that modulates the frequency, rate or extent of glucosylceramidase activity.


plasma membrane proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the plasma membrane.


nuclear migration along microtubule

The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.


TCRGL_HUMAN Transcription elongation regulator 1-like protein (sprot)

A transcription elongation regulator 1-like protein that is encoded in the genome of human.


SH2D7_HUMAN SH2 domain-containing protein 7 (sprot)

An SH2 domain-containing protein 7 that is encoded in the genome of human.


CO040_HUMAN UPF0235 protein C15orf40 (sprot)

A UPF0235 protein C15orf40 that is encoded in the genome of human.


Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O.


RRP15_HUMAN RRP15-like protein (sprot)

An RRP15-like protein that is encoded in the genome of human.


medium-chain fatty acid transport

The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.


D-lactate dehydrogenase (cytochrome) activity

Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.


Catalysis of the reaction: carboxymethyluridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine.


cytosolic tRNA wobble base thiouridylase complex

A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets.


3'-tRNA processing endoribonuclease activity

Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.


Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.


CCD82_HUMAN Coiled-coil domain-containing protein 82 (sprot)

A coiled-coil domain-containing protein 82 that is encoded in the genome of human.


tRNA N2-guanine methylation

The process whereby a guanine in a tRNA is methylated at the N2 position of guanine.


succinate-CoA ligase complex

A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP.


MAGE2_HUMAN Melanoma-associated antigen E2 (sprot)

A melanoma-associated antigen E2 that is encoded in the genome of human.


mitotic DNA replication preinitiation complex assembly

Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle.


FA53A_HUMAN Protein FAM53A (sprot)

A protein FAM53A that is encoded in the genome of human.


system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.


tRNA metabolic process

The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.


adenine biosynthetic process

The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.


farnesyl diphosphate metabolic process

The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.


TM14D_HUMAN Transmembrane protein 14DP (sprot)

A transmembrane protein 14DP that is encoded in the genome of human.


type 2 orexin receptor binding

Binding to a type 2 orexin receptor.


MAGBH_HUMAN Melanoma-associated antigen B17 (sprot)


palmitoyl-CoA 9-desaturase activity

Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O.


apelin receptor activity

Combining with the peptide apelin to initiate a change in cell activity.


GOG8H_HUMAN Golgin subfamily A member 8H (sprot)

A golgin subfamily A member 8H that is encoded in the genome of human.


UDP-galactose transmembrane import into Golgi lumen

The directed movement of UDP-galactose into the Golgi lumen across the Golgi membrane.


Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage.


mitochondrial seryl-tRNA aminoacylation

The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M.


sperm individualization

The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.


mitochondrial double-strand break repair via homologous recombination

The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences.


F135A_HUMAN Protein FAM135A (sprot)

A protein FAM135A that is encoded in the genome of human.


proteasome core complex assembly

The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles.


Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A).


meiotic DNA recombinase assembly

During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA.


corticotropin-releasing hormone receptor activity

Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity.


UDP-N-acetylgalactosamine transmembrane transporter activity

Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


MRGRG_HUMAN Mas-related G-protein coupled receptor member G (sprot)

A Mas-related G-protein coupled receptor G that is encoded in the genome of human.


GLCI1_HUMAN Glucocorticoid-induced transcript 1 protein (sprot)

A glucocorticoid-induced transcript 1 protein that is encoded in the genome of human.