ABCE1_HUMAN ATP-binding cassette sub-family E member 1 (sprot)

An ATP-binding cassette sub-family E member 1 that is encoded in the genome of human.


RAP1B_HUMAN Ras-related protein Rap-1b (sprot)

A Ras-related protein Rap-1b that is encoded in the genome of human.


regulation of cell junction assembly

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that modulates the frequency, rate or extent of cell junction assembly.


RAP2B_HUMAN Ras-related protein Rap-2b (sprot)

A Ras-related protein Rap-2b that is encoded in the genome of human.


YPEL3_HUMAN Protein yippee-like 3 (sprot)

A protein yippee-like 3 that is encoded in the genome of human.


MAX_HUMAN Protein max (sprot)

A protein max that is encoded in the genome of human.


Mad-Max complex

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A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max.


RS3A_HUMAN Small ribosomal subunit protein eS1 (sprot)

A 40S ribosomal protein S3a that is encoded in the genome of human.


RL26_HUMAN Large ribosomal subunit protein uL24 (sprot)

A 60S ribosomal protein L26 that is encoded in the genome of human.


positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.


regulation of translation involved in cellular response to UV

Any regulation of translation that is involved in cellular response to UV.


STX1B_HUMAN Syntaxin-1B (sprot)

A syntaxin-1B that is encoded in the genome of human.


regulation of synaptic vesicle priming

Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.


negative regulation of synaptic vesicle recycling

Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle recycling.


positive regulation of spontaneous neurotransmitter secretion

Any process that activates or increases the frequency, rate or extent of spontaneous neurotransmitter secretion.


negative regulation of macropinocytosis

Any process that stops, prevents or reduces the frequency, rate or extent of macropinocytosis.


SMS_HUMAN Somatostatin (sprot)

A somatostatin that is encoded in the genome of human.


PSME3_HUMAN Proteasome activator complex subunit 3 (sprot)

A proteasome activator complex subunit 3 that is encoded in the genome of human.


proteasome activator complex

A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex.


HAND2_HUMAN Heart- and neural crest derivatives-expressed protein 2 (sprot)

A heart- and neural crest derivatives-expressed protein 2 that is encoded in the genome of human.


cardiac neural crest cell development involved in outflow tract morphogenesis

The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.


cell proliferation involved in outflow tract morphogenesis

The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract.


primary palate development

The process whose specific outcome is the progression of a primary palate over time, from its formation to the mature structure.


positive regulation of semaphorin-plexin signaling pathway

Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway.


RL15_HUMAN Large ribosomal subunit protein eL15 (sprot)

A 60S ribosomal protein L15 that is encoded in the genome of human.


MGN_HUMAN Protein mago nashi homolog (sprot)

A protein mago nashi that is encoded in the genome of human.


exon-exon junction subcomplex mago-y14

Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA.


FGF12_HUMAN Fibroblast growth factor 12 (sprot)

A fibroblast growth factor 12 that is encoded in the genome of human.


regulation of voltage-gated sodium channel activity

Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity.


RL27_HUMAN Large ribosomal subunit protein eL27 (sprot)

A 60S ribosomal protein L27 that is encoded in the genome of human.


cytoplasmic side of rough endoplasmic reticulum membrane

The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm.


OSTN_HUMAN Osteocrin (sprot)

An osteocrin that is encoded in the genome of human.


ISL1_HUMAN Insulin gene enhancer protein ISL-1 (sprot)

An insulin gene enhancer protein ISL-1 that is encoded in the genome of human.


visceral motor neuron differentiation

The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


positive regulation of interleukin-1 alpha production

Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production.


sensory system development

The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure.


cardiac cell fate determination

The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.


positive regulation of macrophage colony-stimulating factor production

Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor production.


VA0D1_HUMAN V-type proton ATPase subunit d 1 (sprot)

A V-type proton ATPase subunit d 1 that is encoded in the genome of human.


PHS_HUMAN Pterin-4-alpha-carbinolamine dehydratase (sprot)

A pterin-4-alpha-carbinolamine dehydratase that is encoded in the genome of human.


RL37A_HUMAN Large ribosomal subunit protein eL43 (sprot)

A 60S ribosomal protein L37a that is encoded in the genome of human.


ENVT1_HUMAN Endogenous retrovirus group S71 member 1 Env polyprotein (sprot)

A protein that is a translation product of the ERVS71-1 gene in human.


ENK21_HUMAN Endogenous retrovirus group K member 21 Env polyprotein (sprot)


RE113_HUMAN Endogenous retrovirus group K member 113 Rec protein (sprot)


REC04_HUMAN Endogenous retrovirus group K member 104 Rec protein (sprot)


REC16_HUMAN Endogenous retrovirus group K member 16 Rec protein (sprot)

A protein that is a translation product of the ERVK-16 gene in human.


RHOA_HUMAN Transforming protein RhoA (sprot)

A GTP-binding protein RhoA that is encoded in the genome of human.


endothelial tube lumen extension

Any endothelial tube morphogenesis process by which the tube is increased in length.


angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure

The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream.


alpha-beta T cell lineage commitment

The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell.


cleavage furrow formation

Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.


bone trabecula morphogenesis

The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod.


mitotic cleavage furrow formation

Any cleavage furrow formation that is involved in mitotic cell cycle.


positive regulation of vascular associated smooth muscle contraction

Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction.


regulation of modification of postsynaptic actin cytoskeleton

Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.


RND3_HUMAN Rho-related GTP-binding protein RhoE (sprot)

A Rho-related GTP-binding protein RhoE that is encoded in the genome of human.


NAA20_HUMAN N-alpha-acetyltransferase 20 (sprot)

An N-alpha-acetyltransferase 20 that is encoded in the genome of human.


N-terminal peptidyl-aspartic acid acetylation

The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase.


The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable.


N-terminal peptidyl-glutamic acid acetylation

The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid.


NatB complex

A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.


NCALD_HUMAN Neurocalcin-delta (sprot)

A neurocalcin-delta that is encoded in the genome of human.


CH10_HUMAN 10 kDa heat shock protein, mitochondrial (sprot)

A 10 kDa heat shock protein, mitochondrial that is encoded in the genome of human.


S61A1_HUMAN Protein transport protein Sec61 subunit alpha isoform 1 (sprot)

A protein transport protein Sec61 subunit alpha isoform 1 that is encoded in the genome of human.


pronephric nephron development

The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros.


LYSC_HUMAN Lysozyme C (sprot)

A lysozyme C that is encoded in the genome of human.


lysozyme activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan.


SIA8F_HUMAN Alpha-2,8-sialyltransferase 8F (sprot)

An alpha-2,8-sialyltransferase 8F that is encoded in the genome of human.


glycolipid biosynthetic process

The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).


PFD3_HUMAN Prefoldin subunit 3 (sprot)

A prefoldin subunit 3 that is encoded in the genome of human.


STXB1_HUMAN Syntaxin-binding protein 1 (sprot)

A syntaxin-binding protein 1 that is encoded in the genome of human.


positive regulation of vesicle docking

Any process that activates or increases the frequency, rate or extent of vesicle docking.


regulation of acrosomal vesicle exocytosis

Any process that modulates the frequency, rate or extent of acrosomal vesicle exocytosis.


B2MG_HUMAN Beta-2-microglobulin (sprot)

A beta-2-microglobulin that is encoded in the genome of human.


antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


cellular response to iron(III) ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus.


positive regulation of ferrous iron binding

Any process that activates or increases the frequency, rate or extent of ferrous iron binding.


positive regulation of transferrin receptor binding

Any process that activates or increases the frequency, rate or extent of transferrin receptor binding.


negative regulation of forebrain neuron differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.


DAD1_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (sprot)

A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 that is encoded in the genome of human.


TGFB2_HUMAN Transforming growth factor beta-2 proprotein (sprot)

A TGF-beta 2 that is encoded in the genome of human.


regulation of transforming growth factor beta2 production

Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2.


ascending aorta morphogenesis

The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.


regulation of timing of catagen

Any process that modulates the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle.


regulation of apoptotic process involved in outflow tract morphogenesis

Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.


negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

Any process that stops, prevents or reduces the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation.


NPC2_HUMAN NPC intracellular cholesterol transporter 2 (sprot)

An NPC intracellular cholesterol transporter 2 that is encoded in the genome of human.


regulation of isoprenoid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.


intracellular sterol transport

The directed movement of sterols within cells.


COPZ1_HUMAN Coatomer subunit zeta-1 (sprot)

A coatomer subunit zeta-1 that is encoded in the genome of human.


IPKA_HUMAN cAMP-dependent protein kinase inhibitor alpha (sprot)

A cAMP-dependent protein kinase inhibitor alpha that is encoded in the genome of human.


RL37_HUMAN Large ribosomal subunit protein eL37 (sprot)

A 60S ribosomal protein L37 that is encoded in the genome of human.


GBG11_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (sprot)

A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 that is encoded in the genome of human.


SUMO2_HUMAN Small ubiquitin-related modifier 2 (sprot)

A small ubiquitin-related modifier 2 that is encoded in the genome of human.


UFM1_HUMAN Ubiquitin-fold modifier 1 (sprot)

A ubiquitin-fold modifier 1 that is encoded in the genome of human.


DCAF7_HUMAN DDB1- and CUL4-associated factor 7 (sprot)

A DDB1- and CUL4-associated factor 7 that is encoded in the genome of human.


Cul4-RING E3 ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.


WDR5_HUMAN WD repeat-containing protein 5 (sprot)

A WD repeat-containing protein 5 that is encoded in the genome of human.


AP1S1_HUMAN AP-1 complex subunit sigma-1A (sprot)

An AP-1 complex subunit sigma-1A that is encoded in the genome of human.


LMO4_HUMAN LIM domain transcription factor LMO4 (sprot)

A LIM domain transcription factor LMO4 that is encoded in the genome of human.


regulation of cell activation

Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.


NTF2_HUMAN Nuclear transport factor 2 (sprot)

A nuclear transport factor 2 that is encoded in the genome of human.


protein localization to nuclear pore

A process in which a protein is transported to, or maintained in, a nuclear pore.


HNRPK_HUMAN Heterogeneous nuclear ribonucleoprotein K (sprot)

A heterogeneous nuclear ribonucleoprotein K that is encoded in the genome of human.


regulation of low-density lipoprotein particle clearance

Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.


1433G_HUMAN 14-3-3 protein gamma (sprot)

A 14-3-3 protein gamma that is encoded in the genome of human.


UBP46_HUMAN Ubiquitin carboxyl-terminal hydrolase 46 (sprot)

A ubiquitin carboxyl-terminal hydrolase 46 that is encoded in the genome of human.


RRAS2_HUMAN Ras-related protein R-Ras2 (sprot)

A Ras-related protein R-Ras2 that is encoded in the genome of human.


positive regulation of Schwann cell migration

Any process that activates or increases the frequency, rate or extent of Schwann cell migration.


TIM10_HUMAN Mitochondrial import inner membrane translocase subunit Tim10 (sprot)

A mitochondrial import inner membrane translocase subunit Tim10 that is encoded in the genome of human.


TIM22 mitochondrial import inner membrane insertion complex

A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12.


TSN5_HUMAN Tetraspanin-5 (sprot)

A tetraspanin-5 that is encoded in the genome of human.


RS7_HUMAN Small ribosomal subunit protein eS7 (sprot)

A 40S ribosomal protein S7 that is encoded in the genome of human.


PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (sprot)

A serine/threonine-protein phosphatase PP1-alpha catalytic subunit that is encoded in the genome of human.


PP1B_HUMAN Serine/threonine-protein phosphatase PP1-beta catalytic subunit (sprot)

A serine/threonine-protein phosphatase PP1-beta catalytic subunit that is encoded in the genome of human.


myosin-light-chain-phosphatase activity

Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate.


NCS1_HUMAN Neuronal calcium sensor 1 (sprot)

A neuronal calcium sensor 1 that is encoded in the genome of human.


PRS4_HUMAN 26S proteasome regulatory subunit 4 (sprot)

A 26S proteasome regulatory subunit 4 that is encoded in the genome of human.


PRS8_HUMAN 26S proteasome regulatory subunit 8 (sprot)

A 26S proteasome regulatory subunit 8 that is encoded in the genome of human.


thyrotropin-releasing hormone receptor binding

Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary.


RS8_HUMAN Small ribosomal subunit protein eS8 (sprot)

A 40S ribosomal protein S8 that is encoded in the genome of human.


RS15A_HUMAN Small ribosomal subunit protein uS8 (sprot)

A 40S ribosomal protein S15a that is encoded in the genome of human.


RS16_HUMAN Small ribosomal subunit protein uS9 (sprot)

A 40S ribosomal protein S16 that is encoded in the genome of human.


small ribosomal subunit

The smaller of the two subunits of a ribosome.


UB2G1_HUMAN Ubiquitin-conjugating enzyme E2 G1 (sprot)

A ubiquitin-conjugating enzyme E2 G1 that is encoded in the genome of human.


UBE2H_HUMAN Ubiquitin-conjugating enzyme E2 H (sprot)

A ubiquitin-conjugating enzyme E2 H that is encoded in the genome of human.


1433E_HUMAN 14-3-3 protein epsilon (sprot)

A 14-3-3 protein epsilon that is encoded in the genome of human.


regulation of heart rate by hormone

The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.


negative regulation of peptidyl-serine dephosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation.


RS14_HUMAN Small ribosomal subunit protein uS11 (sprot)

A 40S ribosomal protein S14 that is encoded in the genome of human.


RS23_HUMAN Small ribosomal subunit protein uS12 (sprot)

A 40S ribosomal protein S23 that is encoded in the genome of human.


maintenance of translational fidelity

Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template.


RS18_HUMAN Small ribosomal subunit protein uS13 (sprot)

A 40S ribosomal protein S18 that is encoded in the genome of human.


RS29_HUMAN Small ribosomal subunit protein uS14 (sprot)

A 40S ribosomal protein S29 that is encoded in the genome of human.


RS13_HUMAN Small ribosomal subunit protein uS15 (sprot)

A 40S ribosomal protein S13 that is encoded in the genome of human.


RS11_HUMAN Small ribosomal subunit protein uS17 (sprot)

A 40S ribosomal protein S11 that is encoded in the genome of human.


RUXE_HUMAN Small nuclear ribonucleoprotein E (sprot)

A small nuclear ribonucleoprotein E that is encoded in the genome of human.


RUXF_HUMAN Small nuclear ribonucleoprotein F (sprot)

A small nuclear ribonucleoprotein F that is encoded in the genome of human.


RUXG_HUMAN Small nuclear ribonucleoprotein G (sprot)

A small nuclear ribonucleoprotein G that is encoded in the genome of human.


LSM3_HUMAN U6 snRNA-associated Sm-like protein LSm3 (sprot)

A U6 snRNA-associated Sm-like protein LSm3 that is encoded in the genome of human.


U6 snRNA 3'-end binding

Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end.


LSM6_HUMAN U6 snRNA-associated Sm-like protein LSm6 (sprot)

A U6 snRNA-associated Sm-like protein LSm6 that is encoded in the genome of human.


SMD1_HUMAN Small nuclear ribonucleoprotein Sm D1 (sprot)

A small nuclear ribonucleoprotein Sm D1 that is encoded in the genome of human.


SMD2_HUMAN Small nuclear ribonucleoprotein Sm D2 (sprot)

A small nuclear ribonucleoprotein Sm D2 that is encoded in the genome of human.


SMD3_HUMAN Small nuclear ribonucleoprotein Sm D3 (sprot)

A small nuclear ribonucleoprotein Sm D3 that is encoded in the genome of human.


U7 snRNA binding

Binding to a U7 small nuclear RNA (U7 snRNA).


BTG1_HUMAN Protein BTG1 (sprot)

A protein BTG1 that is encoded in the genome of human.


TYB4_HUMAN Thymosin beta-4 (sprot)

A thymosin beta-4 that is encoded in the genome of human.


positive regulation of proton-transporting ATP synthase activity, rotational mechanism

Any process that activates or increases the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism.


ARF6_HUMAN ADP-ribosylation factor 6 (sprot)

An ADP-ribosylation factor 6 that is encoded in the genome of human.


protein localization to endosome

A process in which a protein is transported to, or maintained in, a location within an endosome.


maintenance of postsynaptic density structure

A process which maintains the organization and the arrangement of proteins in the presynaptic density.


erythrocyte apoptotic process

Any apoptotic process in an erythrocyte.


PRS10_HUMAN 26S proteasome regulatory subunit 10B (sprot)

A 26S proteasome regulatory subunit 10B that is encoded in the genome of human.


SELT_HUMAN Thioredoxin reductase-like selenoprotein T (sprot)

A thioredoxin reductase-like selenoprotein T that is encoded in the genome of human.


TBPL1_HUMAN TATA box-binding protein-like 1 (sprot)

A TATA box-binding protein-like 1 that is encoded in the genome of human.


RL7A_HUMAN Large ribosomal subunit protein eL8 (sprot)

A 60S ribosomal protein L7a that is encoded in the genome of human.


RPB7_HUMAN DNA-directed RNA polymerase II subunit RPB7 (sprot)

A DNA-directed RNA polymerase II subunit RPB7 that is encoded in the genome of human.


RB11A_HUMAN Ras-related protein Rab-11A (sprot)

A Ras-related protein Rab-11A that is encoded in the genome of human.


regulation of multivesicular body size

Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles.


ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (sprot)

A eukaryotic peptide chain release factor subunit 1 that is encoded in the genome of human.


aminoacyl-tRNA hydrolase activity

Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.


translation termination factor activity

Functions in the termination of translation.


LCN6_HUMAN Epididymal-specific lipocalin-6 (sprot)

An epididymal-specific lipocalin-6 that is encoded in the genome of human.


ERR3_HUMAN Estrogen-related receptor gamma (sprot)

An estrogen-related receptor gamma that is encoded in the genome of human.


AF-2 domain binding

Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation.


CNBP_HUMAN CCHC-type zinc finger nucleic acid binding protein (sprot)

A CCHC-type zinc finger nucleic acid binding protein that is encoded in the genome of human.


G-quadruplex DNA formation

A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature.


GA113_HUMAN Endogenous retrovirus group K member 113 Gag polyprotein (sprot)


YPEL5_HUMAN Protein yippee-like 5 (sprot)

A protein yippee-like 5 that is encoded in the genome of human.


RS4X_HUMAN Small ribosomal subunit protein eS4, X isoform (sprot)

A 40S ribosomal protein S4, X isoform that is encoded in the genome of human.


PP2AB_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (sprot)

A serine/threonine-protein phosphatase 2A catalytic subunit beta isoform that is encoded in the genome of human.


ACTA_HUMAN Actin, aortic smooth muscle (sprot)

An actin, aortic smooth muscle that is encoded in the genome of human.


positive regulation of hepatic stellate cell migration

Any process that increases the frequency, rate or extent of hepatic stellate cell migration.


positive regulation of hepatic stellate cell contraction

Any process that activates or increases the frequency, rate or extent of hepatic stellate cell contraction.


mesenchyme migration

The process in which the population of cells that make up a mesenchyme undergo directed movement.


RHOB_HUMAN Rho-related GTP-binding protein RhoB (sprot)

A Rho-related GTP-binding protein RhoB that is encoded in the genome of human.


RL23A_HUMAN Large ribosomal subunit protein uL23 (sprot)

A 60S ribosomal protein L23a that is encoded in the genome of human.


RS6_HUMAN Small ribosomal subunit protein eS6 (sprot)

A 40S ribosomal protein S6 that is encoded in the genome of human.


VISL1_HUMAN Visinin-like protein 1 (sprot)

A visinin-like protein 1 that is encoded in the genome of human.


H4_HUMAN Histone H4 (sprot)

A histone H4 that is encoded in the genome of human.


telomere organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.


H2B1C_HUMAN Histone H2B type 1-C/E/F/G/I (sprot)

A histone H2B type 1-C/E/F/G/I that is encoded in the genome of human.


RAB1A_HUMAN Ras-related protein Rab-1A (sprot)

A Ras-related protein Rab-1A that is encoded in the genome of human.


positive regulation of glycoprotein metabolic process

Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process.


RAN_HUMAN GTP-binding nuclear protein Ran (sprot)

A GTP-binding nuclear protein Ran that is encoded in the genome of human.


pre-miRNA export from nucleus

Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product.


protein localization to nucleolus

A process in which a protein is transported to, or maintained in, a location within a nucleolus.


RNA nuclear export complex

A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore.


RL23_HUMAN Large ribosomal subunit protein uL14 (sprot)

A 60S ribosomal protein L23 that is encoded in the genome of human.


RAP1A_HUMAN Ras-related protein Rap-1A (sprot)

A Ras-related protein Rap-1A that is encoded in the genome of human.


guanyl-nucleotide exchange factor complex

A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.


UB2D2_HUMAN Ubiquitin-conjugating enzyme E2 D2 (sprot)

A ubiquitin-conjugating enzyme E2 D2 that is encoded in the genome of human.


RS15_HUMAN Small ribosomal subunit protein uS19 (sprot)

A 40S ribosomal protein S15 that is encoded in the genome of human.


RS24_HUMAN Small ribosomal subunit protein eS24 (sprot)

A 40S ribosomal protein S24 that is encoded in the genome of human.


RS25_HUMAN Small ribosomal subunit protein eS25 (sprot)

A 40S ribosomal protein S25 that is encoded in the genome of human.


RS26_HUMAN Small ribosomal subunit protein eS26 (sprot)

A 40S ribosomal protein S26 that is encoded in the genome of human.


RS28_HUMAN Small ribosomal subunit protein eS28 (sprot)

A 40S ribosomal protein S28 that is encoded in the genome of human.


RS30_HUMAN Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein (sprot)

A FAU ubiquitin-like and ribosomal protein S30 that is encoded in the genome of human.


GBB1_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (sprot)

A guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 that is encoded in the genome of human.


RPAB5_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC5 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC5 that is encoded in the genome of human.


RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 (sprot)

An E3 ubiquitin-protein ligase RBX1 that is encoded in the genome of human.


NEDD8 ligase activity

Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.


ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.


positive regulation of protein autoubiquitination

Any process that activates or increases the frequency, rate or extent of protein autoubiquitination.


negative regulation of response to oxidative stress

Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress.


cullin-RING ubiquitin ligase complex

Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.


Cul4B-RING E3 ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.


Cul7-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.


GBB2_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (sprot)

A guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 that is encoded in the genome of human.


RL30_HUMAN Large ribosomal subunit protein eL30 (sprot)

A 60S ribosomal protein L30 that is encoded in the genome of human.


RL39_HUMAN Large ribosomal subunit protein eL39 (sprot)

A 60S ribosomal protein L39 that is encoded in the genome of human.


RL31_HUMAN Large ribosomal subunit protein eL31 (sprot)

A 60S ribosomal protein L31 that is encoded in the genome of human.


RL10A_HUMAN Large ribosomal subunit protein uL1 (sprot)

A 60S ribosomal protein L10a that is encoded in the genome of human.


RL32_HUMAN Large ribosomal subunit protein eL32 (sprot)

A 60S ribosomal protein L32 that is encoded in the genome of human.


RL11_HUMAN Large ribosomal subunit protein uL5 (sprot)

A 60S ribosomal protein L11 that is encoded in the genome of human.


RL8_HUMAN Large ribosomal subunit protein uL2 (sprot)

A 60S ribosomal protein L8 that is encoded in the genome of human.


PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A (sprot)

A peptidyl-prolyl cis-trans isomerase A that is encoded in the genome of human.


cell adhesion molecule production

The appearance of a cell adhesion molecule due to biosynthesis or secretion.


negative regulation of protein K48-linked ubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


negative regulation of viral life cycle

Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle.


regulation of apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.


FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP1A that is encoded in the genome of human.


macrolide binding

Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species.


signaling receptor inhibitor activity

Binds to and modulates the activity of a signaling receptor.


cytoplasmic side of membrane

The side of a membrane that faces the cytoplasm.


RL41_HUMAN Large ribosomal subunit protein eL41 (sprot)

A 60S ribosomal protein L41 that is encoded in the genome of human.


BLCAP_HUMAN Bladder cancer-associated protein (sprot)

A bladder cancer-associated protein that is encoded in the genome of human.


CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit (sprot)

A voltage-dependent calcium channel gamma-7 subunit that is encoded in the genome of human.


RS27A_HUMAN Ubiquitin-ribosomal protein eS31 fusion protein (sprot)

A ubiquitin-40S ribosomal protein S27a that is encoded in the genome of human.


RL40_HUMAN Ubiquitin-ribosomal protein eL40 fusion protein (sprot)

A ubiquitin-60S ribosomal protein L40 that is encoded in the genome of human.


GRB2_HUMAN Growth factor receptor-bound protein 2 (sprot)

A growth factor receptor-bound protein 2 that is encoded in the genome of human.


guanyl-nucleotide exchange factor adaptor activity

The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.


Grb2-EGFR complex

A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway.


TRA2B_HUMAN Transformer-2 protein homolog beta (sprot)

A transformer-2 protein homolog beta that is encoded in the genome of human.


RAC1_HUMAN Ras-related C3 botulinum toxin substrate 1 (sprot)

A Ras-related C3 botulinum toxin substrate 1 that is encoded in the genome of human.


AP2B1_HUMAN AP-2 complex subunit beta (sprot)

An AP-2 complex subunit beta that is encoded in the genome of human.


signal sequence binding

Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.


VAMP2_HUMAN Vesicle-associated membrane protein 2 (sprot)

A vesicle-associated membrane protein 2 that is encoded in the genome of human.


synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).


GNAI1_HUMAN Guanine nucleotide-binding protein G(i) subunit alpha-1 (sprot)

A guanine nucleotide-binding protein G(i) subunit alpha-1 that is encoded in the genome of human.


D2 dopamine receptor binding

Binding to a D2 dopamine receptor.


CANB1_HUMAN Calcineurin subunit B type 1 (sprot)

A calcineurin subunit B type 1 that is encoded in the genome of human.


1433Z_HUMAN 14-3-3 protein zeta/delta (sprot)

A 14-3-3 protein zeta/delta that is encoded in the genome of human.


synaptic target recognition

The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.


VP113_HUMAN Endogenous retrovirus group K member 113 Pro protein (sprot)


VPK04_HUMAN Endogenous retrovirus group K member 104 Pro protein (sprot)


POK9_HUMAN Endogenous retrovirus group K member 9 Pol protein (sprot)


PO113_HUMAN Endogenous retrovirus group K member 113 Pol protein (sprot)


POK8_HUMAN Endogenous retrovirus group K member 8 Pol protein (sprot)


POK7_HUMAN Endogenous retrovirus group K member 7 Pol protein (sprot)


POK25_HUMAN Endogenous retrovirus group K member 25 Pol protein (sprot)


GAK24_HUMAN Endogenous retrovirus group K member 24 Gag polyprotein (sprot)


UBE2B_HUMAN Ubiquitin-conjugating enzyme E2 B (sprot)

A ubiquitin-conjugating enzyme E2 B that is encoded in the genome of human.


positive regulation of reciprocal meiotic recombination

Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.


chiasma assembly

The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids.


synaptonemal complex organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis.


2ABA_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (sprot)

A serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform that is encoded in the genome of human.


RSMN_HUMAN Small nuclear ribonucleoprotein-associated protein N (sprot)

A small nuclear ribonucleoprotein-associated protein N that is encoded in the genome of human.


SUMO1_HUMAN Small ubiquitin-related modifier 1 (sprot)

A small ubiquitin-related modifier 1 that is encoded in the genome of human.


small protein activating enzyme binding

Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme.


DYL1_HUMAN Dynein light chain 1, cytoplasmic (sprot)

A dynein light chain 1, cytoplasmic that is encoded in the genome of human.


negative regulation of DNA strand resection involved in replication fork processing

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing.


DYLT1_HUMAN Dynein light chain Tctex-type 1 (sprot)

A dynein light chain Tctex-type 1 that is encoded in the genome of human.


microtubule-dependent intracellular transport of viral material towards nucleus

The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules.


RL38_HUMAN Large ribosomal subunit protein eL38 (sprot)

A 60S ribosomal protein L38 that is encoded in the genome of human.


90S preribosome assembly

The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome. The 90S preribosome represents the complex that forms on the primary rRNA transcript before it splits into the small subunit and large subunit portions.


eukaryotic 80S initiation complex

A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region.


SKP1_HUMAN S-phase kinase-associated protein 1 (sprot)

An S-phase kinase-associated protein 1A that is encoded in the genome of human.


ubiquitin ligase complex scaffold activity

The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way.


GBG1_HUMAN Guanine nucleotide-binding protein G(T) subunit gamma-T1 (sprot)

A guanine nucleotide-binding protein G(T) subunit gamma-T1 that is encoded in the genome of human.


GBG3_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 (sprot)

A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 that is encoded in the genome of human.


GBG5_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (sprot)

A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 that is encoded in the genome of human.


positive regulation of secondary heart field cardioblast proliferation

Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).


RS21_HUMAN Small ribosomal subunit protein eS21 (sprot)

A 40S ribosomal protein S21 that is encoded in the genome of human.


IF5A1_HUMAN Eukaryotic translation initiation factor 5A-1 (sprot)

A eukaryotic translation initiation factor 5A-1 that is encoded in the genome of human.


positive regulation of translational elongation

Any process that activates or increases the frequency, rate or extent of translational elongation.


positive regulation of translational termination

Any process that activates or increases the frequency, rate or extent of translational termination.


RACK1_HUMAN Small ribosomal subunit protein RACK1 (sprot)

A receptor of activated protein C kinase 1 that is encoded in the genome of human.


negative regulation of endoplasmic reticulum unfolded protein response

Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.


negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide.


KCNJ2_HUMAN Inward rectifier potassium channel 2 (sprot)

An inward rectifier potassium channel 2 that is encoded in the genome of human.


regulation of skeletal muscle contraction via regulation of action potential

Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes.


magnesium ion transport

The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


ACTG_HUMAN Actin, cytoplasmic 2 (sprot)

An actin, cytoplasmic 2 that is encoded in the genome of human.


basal body patch

The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster.


ACTH_HUMAN Actin, gamma-enteric smooth muscle (sprot)

An actin, gamma-enteric smooth muscle that is encoded in the genome of human.


SPT4H_HUMAN Transcription elongation factor SPT4 (sprot)

A transcription elongation factor SPT4 that is encoded in the genome of human.


UBC9_HUMAN SUMO-conjugating enzyme UBC9 (sprot)

A SUMO-conjugating enzyme UBC9 that is encoded in the genome of human.


SUMO conjugating enzyme activity

Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue.


positive regulation of SUMO transferase activity

Any process that activates or increases the frequency, rate or extent of SUMO transferase activity.


SELW_HUMAN Selenoprotein W (sprot)

A selenoprotein W that is encoded in the genome of human.


TYB10_HUMAN Thymosin beta-10 (sprot)

A thymosin beta-10 that is encoded in the genome of human.


TNNC1_HUMAN Troponin C, slow skeletal and cardiac muscles (sprot)

A troponin C, slow skeletal and cardiac muscles that is encoded in the genome of human.


regulation of muscle filament sliding speed

Any process that modulates the velocity of muscle filament sliding.


PP2AA_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (sprot)

A serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform that is encoded in the genome of human.


YBOX1_HUMAN Y-box-binding protein 1 (sprot)

A Y-box-binding protein 1 that is encoded in the genome of human.


Binding to an RNA molecule modified by C5-methylcytidine.


tRNA transport

The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


SC11A_HUMAN Signal peptidase complex catalytic subunit SEC11A (sprot)

A signal peptidase complex catalytic subunit SEC11A that is encoded in the genome of human.


CSK2B_HUMAN Casein kinase II subunit beta (sprot)

A casein kinase II subunit beta that is encoded in the genome of human.


disruption by symbiont of host cell PML body

The breakdown, by the symbiont, of a PML body within a host cell. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction.


TPM4_HUMAN Tropomyosin alpha-4 chain (sprot)

A tropomyosin alpha-4 chain that is encoded in the genome of human.


ACTC_HUMAN Actin, alpha cardiac muscle 1 (sprot)

An actin, alpha cardiac muscle 1 that is encoded in the genome of human.


actin-myosin filament sliding

The sliding movement of actin thin filaments and myosin thick filaments past each other.


UB2L3_HUMAN Ubiquitin-conjugating enzyme E2 L3 (sprot)

A ubiquitin-conjugating enzyme E2 L3 that is encoded in the genome of human.


EF1A1_HUMAN Elongation factor 1-alpha 1 (sprot)

An elongation factor 1-alpha 1 that is encoded in the genome of human.


regulation of D-erythro-sphingosine kinase activity

Any process that modulates the frequency, rate or extent of D-erythro-sphingosine kinase activity.


FKB1B_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1B (sprot)

A peptidyl-prolyl cis-trans isomerase FKBP1B that is encoded in the genome of human.


positive regulation of sequestering of calcium ion

Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


ACTS_HUMAN Actin, alpha skeletal muscle (sprot)

An actin, alpha skeletal muscle that is encoded in the genome of human.


TBA1B_HUMAN Tubulin alpha-1B chain (sprot)

A tubulin alpha-1B chain that is encoded in the genome of human.


TBA4A_HUMAN Tubulin alpha-4A chain (sprot)

A tubulin alpha-4A chain that is encoded in the genome of human.


TBB4B_HUMAN Tubulin beta-4B chain (sprot)

A tubulin beta-4B chain that is encoded in the genome of human.


CSK21_HUMAN Casein kinase II subunit alpha (sprot)

A casein kinase II subunit alpha that is encoded in the genome of human.


Sin3-type complex

Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.


PA1B2_HUMAN Platelet-activating factor acetylhydrolase IB subunit alpha2 (sprot)

A platelet-activating factor acetylhydrolase IB subunit alpha2 that is encoded in the genome of human.


H31_HUMAN Histone H3.1 (sprot)

A histone H3 that is a translation product of any of the following genes in human: HIST1H3A/HIST1H3B/HIST1H3C/HIST1H3D/HIST1H3E/HIST1H3F/HIST1H3G/HIST1H3H/HIST1H3I/HIST1H3J.


UBX2A_HUMAN UBX domain-containing protein 2A (sprot)

A UBX domain-containing protein 2A that is encoded in the genome of human.


HBB_HUMAN Hemoglobin subunit beta (sprot)

A hemoglobin subunit beta that is encoded in the genome of human.


haptoglobin binding

Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex.


NOMO3_HUMAN BOS complex subunit NOMO3 (sprot)

A nodal modulator 3 that is encoded in the genome of human.


multi-pass transmembrane protein insertion into ER membrane

A process of protein insertion of multi-pass membrane proteins into the endoplasmic reticulum (ER) membrane. Insertion of multi-pass membrane proteins is mediated by the multi-pass translocon complex and takes place following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex to promote insertion of subsequent transmembrane regions.


negative regulation of nodal signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway.


multi-pass translocon complex

A protein complex that mediates the insertion of multi-pass transmembrane proteins into endoplasmic reticulum (ER) membrane. Substrates enter via the lateral gate of the Sec61 translocon. The complex comprises the GEL subcomplex (composed of RAB5IF/OPTI and TMCO1), the BOS subcomplex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT subcomplex (composed of WDR83OS/Asterix and CCDC47).


HBG1_HUMAN Hemoglobin subunit gamma-1 (sprot)

A hemoglobin subunit gamma-1 that is encoded in the genome of human.


HBG2_HUMAN Hemoglobin subunit gamma-2 (sprot)

A hemoglobin subunit gamma-2 that is encoded in the genome of human.


HBA_HUMAN Hemoglobin subunit alpha (sprot)

A hemoglobin subunit alpha that is encoded in the genome of human.


CXAR_HUMAN Coxsackievirus and adenovirus receptor (sprot)

A coxsackievirus and adenovirus receptor that is encoded in the genome of human.


cell adhesive protein binding involved in AV node cell-bundle of His cell communication

Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells.


AV node cell to bundle of His cell communication

The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


AV node cell-bundle of His cell adhesion involved in cell communication

The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.


3BP2_HUMAN SH3 domain-binding protein 2 (sprot)

An SH3 domain-binding protein 2 that is encoded in the genome of human.


NOP14_HUMAN Nucleolar protein 14 (sprot)

A nucleolar protein 14 that is encoded in the genome of human.


Noc4p-Nop14p complex

A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.


RNF4_HUMAN E3 ubiquitin-protein ligase RNF4 (sprot)

An E3 ubiquitin-protein ligase RNF4 that is encoded in the genome of human.


regulation of spindle assembly

Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.


regulation of kinetochore assembly

Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.


IGBP1_HUMAN Immunoglobulin-binding protein 1 (sprot)

An immunoglobulin-binding protein 1 that is encoded in the genome of human.


SHPS1_HUMAN Tyrosine-protein phosphatase non-receptor type substrate 1 (sprot)

A tyrosine-protein phosphatase non-receptor type substrate 1 that is encoded in the genome of human.


cell-cell adhesion mediator activity

The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.


cellular response to interleukin-12

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.


negative regulation of I-kappaB phosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation.


ADAM8_HUMAN Disintegrin and metalloproteinase domain-containing protein 8 (sprot)

A disintegrin and metalloproteinase domain-containing protein 8 that is encoded in the genome of human.


positive regulation of fibronectin-dependent thymocyte migration

Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration.


dense core granule membrane

The lipid bilayer surrounding a dense core granule.


CP4F2_HUMAN Cytochrome P450 4F2 (sprot)

A cytochrome P450 4F2 that is encoded in the genome of human.


alkane 1-monooxygenase activity

Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O.


Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase].


arachidonic acid omega-hydroxylase activity

Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid.


Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O .


tocotrienol omega-hydroxylase activity

Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O .


20-hydroxy-leukotriene B4 omega oxidase activity

Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase].


20-aldehyde-leukotriene B4 20-monooxygenase activity

Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase].


pressure natriuresis

The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis).


negative regulation of icosanoid secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell.


positive regulation of icosanoid secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell.


leukotriene B4 catabolic process

The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.


menaquinone catabolic process

The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.


vitamin K catabolic process

The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals.


SERB_HUMAN Phosphoserine phosphatase (sprot)

A phosphoserine phosphatase that is encoded in the genome of human.


L-phosphoserine phosphatase activity

Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid.


RBM6_HUMAN RNA-binding protein 6 (sprot)

An RNA-binding protein 6 that is encoded in the genome of human.


GPC5_HUMAN Glypican-5 (sprot)

A glypican-5 that is encoded in the genome of human.


GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon (sprot)

A gamma-aminobutyric acid receptor subunit epsilon that is encoded in the genome of human.


negative regulation of chloride transport

Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport.


PITX1_HUMAN Pituitary homeobox 1 (sprot)

A pituitary homeobox 1 that is encoded in the genome of human.


myoblast fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


IF4G2_HUMAN Eukaryotic translation initiation factor 4 gamma 2 (sprot)

A eukaryotic translation initiation factor 4 gamma 2 that is encoded in the genome of human.


RPP38_HUMAN Ribonuclease P protein subunit p38 (sprot)

A ribonuclease P protein subunit p38 that is encoded in the genome of human.


RPP30_HUMAN Ribonuclease P protein subunit p30 (sprot)

A ribonuclease P protein subunit p30 that is encoded in the genome of human.


GTF2I_HUMAN General transcription factor II-I (sprot)

A general transcription factor II-I that is encoded in the genome of human.


ASIC1_HUMAN Acid-sensing ion channel 1 (sprot)

An acid-sensing ion channel 1 that is encoded in the genome of human.


monoatomic ion gated channel activity

Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus.


DLG4_HUMAN Disks large homolog 4 (sprot)

A disks large homolog 4 that is encoded in the genome of human.


beta-1 adrenergic receptor binding

Binding to a beta-1 adrenergic receptor.


P2Y1 nucleotide receptor binding

Binding to a P2Y1 nucleotide receptor.


neuroligin family protein binding

Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.


receptor localization to synapse

Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


PI42B_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (sprot)

A phosphatidylinositol 5-phosphate 4-kinase type-2 beta that is encoded in the genome of human.


CNTP1_HUMAN Contactin-associated protein 1 (sprot)

A contactin-associated protein 1 that is encoded in the genome of human.


protein localization to juxtaparanode region of axon

Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon.


postsynaptic density organization

A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.


neuromuscular junction development, skeletal muscle fiber

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber.


paranodal junction maintenance

The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.


CTG1B_HUMAN Cancer/testis antigen 1 (sprot)

A cancer/testis antigen 1 that is encoded in the genome of human.


SRPK2_HUMAN SRSF protein kinase 2 (sprot)

An SRSF protein kinase 2 that is encoded in the genome of human.


ABCA4_HUMAN Retinal-specific phospholipid-transporting ATPase ABCA4 (sprot)

A retinal-specific phospholipid-transporting ATPase ABCA4 that is encoded in the genome of human.


flippase activity

Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


phospholipid transfer to membrane

The transfer of a phospholipid from its site of synthesis to the plasma membrane.


rod photoreceptor disc membrane

Stack of disc membranes located inside a rod photoreceptor outer segment, and containing densely packed molecules of rhodopsin photoreceptor proteins that traverse the lipid bilayer. It is thought that rod disc membranes arise as evaginations of the ciliary membrane near the base of the outer segment, which then become completely separated from the ciliary membrane, during the development of the rod outer segment.


PHC1_HUMAN Polyhomeotic-like protein 1 (sprot)

A polyhomeotic-like protein 1 that is encoded in the genome of human.


NKX32_HUMAN Homeobox protein Nkx-3.2 (sprot)

A homeobox protein Nkx-3.2 that is encoded in the genome of human.


KC1G2_HUMAN Casein kinase I isoform gamma-2 (sprot)

A casein kinase I isoform gamma-2 that is encoded in the genome of human.


CLD10_HUMAN Claudin-10 (sprot)

A claudin-10 that is encoded in the genome of human.


TCPB_HUMAN T-complex protein 1 subunit beta (sprot)

A T-complex protein 1 subunit beta that is encoded in the genome of human.


chaperone mediated protein folding independent of cofactor

The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release.


OLR1_HUMAN Oxidized low-density lipoprotein receptor 1 (sprot)

An oxidized low-density lipoprotein receptor 1 that is encoded in the genome of human.


S35A2_HUMAN UDP-galactose translocator (sprot)

A UDP-galactose translocator that is encoded in the genome of human.


UDP-galactose transmembrane transporter activity

Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate.


UDP-galactose transmembrane transport

The process in which UDP-galactose is transported across a membrane.


S35A1_HUMAN CMP-sialic acid transporter (sprot)

A CMP-sialic acid transporter that is encoded in the genome of human.


CMP-N-acetylneuraminate transmembrane transporter activity

Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other.


The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


S35B1_HUMAN Solute carrier family 35 member B1 (sprot)

A solute carrier family 35 member B1 that is encoded in the genome of human.


UDP-glucose transmembrane transport

The process in which UDP-glucose is transported across a membrane.


KRT83_HUMAN Keratin, type II cuticular Hb3 (sprot)

A keratin, type II cuticular Hb3 that is encoded in the genome of human.


KRT85_HUMAN Keratin, type II cuticular Hb5 (sprot)

A keratin, type II cuticular Hb5 that is encoded in the genome of human.


PRAME_HUMAN Melanoma antigen preferentially expressed in tumors (sprot)

A melanoma antigen preferentially expressed in tumors that is encoded in the genome of human.


CCNA1_HUMAN Cyclin-A1 (sprot)

A cyclin-A1 that is encoded in the genome of human.


RAE1L_HUMAN mRNA export factor RAE1 (sprot)

An mRNA export factor RAE1 that is encoded in the genome of human.


BT3A2_HUMAN Butyrophilin subfamily 3 member A2 (sprot)

A butyrophilin subfamily 3 member A2 that is encoded in the genome of human.


IRX5_HUMAN Iroquois-class homeodomain protein IRX-5 (sprot)

An iroquois-class homeodomain protein IRX-5 that is encoded in the genome of human.


IRX6_HUMAN Iroquois-class homeodomain protein IRX-6 (sprot)

An iroquois-class homeodomain protein IRX-6 that is encoded in the genome of human.


IRX4_HUMAN Iroquois-class homeodomain protein IRX-4 (sprot)

An iroquois-class homeodomain protein IRX-4 that is encoded in the genome of human.


establishment of animal organ orientation

The process that determines the orientation of an animal organ or tissue with reference to an axis.


IRX1_HUMAN Iroquois-class homeodomain protein IRX-1 (sprot)

An iroquois-class homeodomain protein IRX-1 that is encoded in the genome of human.


specification of loop of Henle identity

The process in which the loop of Henle of the kidney nephron acquires its identity.


proximal/distal pattern formation involved in metanephric nephron development

The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end).


IRX3_HUMAN Iroquois-class homeodomain protein IRX-3 (sprot)

An iroquois-class homeodomain protein IRX-3 that is encoded in the genome of human.


Purkinje myocyte development

The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.


His-Purkinje system cell differentiation

The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles.


GSTO1_HUMAN Glutathione S-transferase omega-1 (sprot)

A glutathione S-transferase omega-1 that is encoded in the genome of human.


glutathione dehydrogenase (ascorbate) activity

Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.


methylarsonate reductase activity

Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid.


positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


X3CL1_HUMAN Fractalkine (sprot)

A fractalkine that is encoded in the genome of human.


CXCR1 chemokine receptor binding

Binding to a CXCR1 chemokine receptor.


leukocyte adhesive activation

The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation.


positive regulation of calcium-independent cell-cell adhesion

Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion.


negative regulation of glutamate receptor signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway.


PO6F2_HUMAN POU domain, class 6, transcription factor 2 (sprot)

A POU domain, class 6, transcription factor 2 that is encoded in the genome of human.


NKX61_HUMAN Homeobox protein Nkx-6.1 (sprot)

A homeobox protein Nkx-6.1 that is encoded in the genome of human.


pancreatic A cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.


JAG1_HUMAN Protein jagged-1 (sprot)

A protein jagged-1 that is encoded in the genome of human.


ciliary body morphogenesis

The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes.


endocardial cushion cell development

The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state.


regulation of reproductive process

Any process that modulates the frequency, rate or extent of reproductive process.


KCJ10_HUMAN ATP-sensitive inward rectifier potassium channel 10 (sprot)

An ATP-sensitive inward rectifier potassium channel 10 that is encoded in the genome of human.


glutamate reuptake

The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.


RELN_HUMAN Reelin (sprot)

A reelin that is encoded in the genome of human.


lipoprotein particle receptor binding

Binding to a lipoprotein particle receptor.


spinal cord patterning

The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord.


regulation of synaptic activity

Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell.


postsynaptic density protein 95 clustering

The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins.


positive regulation of lateral motor column neuron migration

Any process that activates or increases the frequency, rate or extent of lateral motor column neuron migration.


reelin complex

An extracellular complex that binds lipoprotein receptors VLDLR and APOER2, cadherin-related neuronal receptors (CNRs) or alpha3beta1 integrin and induces various downstream, reelin-dependent, phosphorylation cascades. It ultimately affects polarization, differentiation, neuronal migration and layer formation in the embryonic brain and neuron growth, maturation, and synaptic activity in the postnatal and adult brain.


DEN2B_HUMAN DENN domain-containing protein 2B (sprot)

A DENN domain-containing protein 2B that is encoded in the genome of human.


PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit (sprot)

A DNA-dependent protein kinase catalytic subunit that is encoded in the genome of human.


DNA-dependent protein kinase activity

DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


histone H2AXS139 kinase activity

Catalysis of the reaction: histone H2AX-serine (position 139) + ATP = histone H2AX-phosphoserine (position 139) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 139 of histone variant H2AX.


ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (sprot)

An ADAM 17 endopeptidase that is encoded in the genome of human.


regulation of mast cell apoptotic process

Any process that modulates the frequency, rate, or extent of mast cell apoptotic process.


BL1S1_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 1 (sprot)

A biogenesis of lysosome-related organelles complex 1 subunit 1 that is encoded in the genome of human.


peptidyl-lysine acetylation

The acetylation of peptidyl-lysine.


SRPX_HUMAN Sushi repeat-containing protein SRPX (sprot)

A sushi repeat-containing protein SRPX that is encoded in the genome of human.


negative regulation of cell proliferation involved in contact inhibition

Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density.


ARGI2_HUMAN Arginase-2, mitochondrial (sprot)

An arginase-2, mitochondrial that is encoded in the genome of human.


arginase activity

Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.


negative regulation of chemokine (C-C motif) ligand 4 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4.


negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process.


BTG2_HUMAN Protein BTG2 (sprot)

A protein BTG2 that is encoded in the genome of human.


ELF3_HUMAN ETS-related transcription factor Elf-3 (sprot)

An ETS-related transcription factor Elf-3 that is encoded in the genome of human.


NTH_HUMAN Endonuclease III-like protein 1 (sprot)

An endonuclease III-like protein 1 that is encoded in the genome of human.


oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.


I13R1_HUMAN Interleukin-13 receptor subunit alpha-1 (sprot)

An interleukin-13 receptor subunit alpha-1 that is encoded in the genome of human.


interleukin-13 receptor complex

A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain.


CCL20_HUMAN C-C motif chemokine 20 (sprot)

A C-C motif chemokine 20 that is encoded in the genome of human.


MAP1A_HUMAN Microtubule-associated protein 1A (sprot)

A microtubule-associated protein 1A that is encoded in the genome of human.


retrograde axonal protein transport

The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.


negative regulation of protein localization to microtubule

Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule.


CRADD_HUMAN Death domain-containing protein CRADD (sprot)

A death domain-containing protein CRADD that is encoded in the genome of human.


PHEX_HUMAN Phosphate-regulating neutral endopeptidase PHEX (sprot)

A phosphate-regulating neutral endopeptidase PHEX that is encoded in the genome of human.


organophosphate metabolic process

The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound.


RED1_HUMAN Double-stranded RNA-specific editase 1 (sprot)

A double-stranded RNA-specific editase 1 that is encoded in the genome of human.


facial nerve morphogenesis

The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.


hypoglossal nerve morphogenesis

The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.


DRB3_HUMAN HLA class II histocompatibility antigen, DR beta 3 chain (sprot)

An MHC class II histocompatibility antigen beta chain DRB3 that is encoded in the genome of human.


PRR3_HUMAN Proline-rich protein 3 (sprot)

A proline-rich protein 3 that is encoded in the genome of human.


CCL8_HUMAN C-C motif chemokine 8 (sprot)

A C-C motif chemokine 8 that is encoded in the genome of human.


CCL7_HUMAN C-C motif chemokine 7 (sprot)

A C-C motif chemokine 7 that is encoded in the genome of human.


PHLD_HUMAN Phosphatidylinositol-glycan-specific phospholipase D (sprot)

A phosphatidylinositol-glycan-specific phospholipase D that is encoded in the genome of human.


glycosylphosphatidylinositol phospholipase D activity

Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.


GPI anchor release

The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane.


positive regulation of alkaline phosphatase activity

Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.


positive regulation of high-density lipoprotein particle clearance

Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


cellular response to triglyceride

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus.


CXCL6_HUMAN C-X-C motif chemokine 6 (sprot)

A C-X-C motif chemokine 6 that is encoded in the genome of human.


regulation of neutrophil mediated killing of gram-negative bacterium

Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil.


NGAL_HUMAN Neutrophil gelatinase-associated lipocalin (sprot)

A neutrophil gelatinase-associated lipocalin that is encoded in the genome of human.


siderophore transport

The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 (sprot)

A mitogen-activated protein kinase kinase kinase 9 that is encoded in the genome of human.


JUN kinase kinase kinase activity

Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).


IN35_HUMAN Interferon-induced 35 kDa protein (sprot)

An interferon-induced 35 kDa protein that is encoded in the genome of human.


MT1H_HUMAN Metallothionein-1H (sprot)

A metallothionein-1H that is encoded in the genome of human.


MT1X_HUMAN Metallothionein-1X (sprot)

A metallothionein-1X that is encoded in the genome of human.


NUCB2_HUMAN Nucleobindin-2 (sprot)

A nucleobindin-2 that is encoded in the genome of human.


DHI2_HUMAN 11-beta-hydroxysteroid dehydrogenase type 2 (sprot)

An 11-beta-hydroxysteroid dehydrogenase type 2 that is encoded in the genome of human.


11-beta-hydroxysteroid dehydrogenase (NAD+) activity

Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+.


cortisol metabolic process

The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


DLK1_HUMAN Protein delta homolog 1 (sprot)

A protein delta homolog 1 that is encoded in the genome of human.


GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial (sprot)

A 4-aminobutyrate aminotransferase, mitochondrial that is encoded in the genome of human.


4-aminobutyrate transaminase activity

Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.


Binding to succinate-semialdehyde dehydrogenase.


Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.


Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.


4-aminobutyrate transaminase complex

A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity.


S10AC_HUMAN Protein S100-A12 (sprot)

A protein S100-A12 that is encoded in the genome of human.


BASP1_HUMAN Brain acid soluble protein 1 (sprot)

A brain acid soluble protein 1 that is encoded in the genome of human.


LV321_HUMAN Immunoglobulin lambda variable 3-21 (sprot)

A protein that is a translation product of the IGLV3-21 gene in human.


SIM1_HUMAN Single-minded homolog 1 (sprot)

A single-minded homolog 1 that is encoded in the genome of human.


HEPC_HUMAN Hepcidin (sprot)

A hepcidin that is encoded in the genome of human.


negative regulation of intestinal absorption

Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption.


GPSM2_HUMAN G-protein-signaling modulator 2 (sprot)

A G-protein-signaling modulator 2 that is encoded in the genome of human.


positive regulation of spindle assembly

Any process that activates or increases the frequency, rate or extent of spindle assembly.


lateral cell cortex

The region directly beneath the plasma membrane of the lateral portion of the cell.


cell cortex region

The complete extent of cell cortex that underlies some some region of the plasma membrane.


PRRP_HUMAN Prolactin-releasing peptide (sprot)

A prolactin-releasing peptide that is encoded in the genome of human.


EREP3_HUMAN Protein ENTREP3 (sprot)

A protein ENTREP3 that is encoded in the genome of human.


D103A_HUMAN Beta-defensin 103 (sprot)

A beta-defensin 103 that is encoded in the genome of human.


DCD_HUMAN Dermcidin (sprot)

A dermcidin that is encoded in the genome of human.


SSBP2_HUMAN Single-stranded DNA-binding protein 2 (sprot)

A single-stranded DNA-binding protein 2 that is encoded in the genome of human.


TMF1_HUMAN TATA element modulatory factor (sprot)

A TATA element modulatory factor that is encoded in the genome of human.


BAT1_HUMAN b(0,+)-type amino acid transporter 1 (sprot)

A b(0,+)-type amino acid transporter 1 that is encoded in the genome of human.


broad specificity neutral L-amino acid:basic L-amino acid antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out).


CRUM1_HUMAN Protein crumbs homolog 1 (sprot)

A protein crumbs homolog 1 that is encoded in the genome of human.


establishment of bipolar cell polarity involved in cell morphogenesis

The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane.


subapical complex

The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.


RT22_HUMAN Small ribosomal subunit protein mS22 (sprot)

A 28S ribosomal protein S22, mitochondrial that is encoded in the genome of human.


RT25_HUMAN Small ribosomal subunit protein mS25 (sprot)

A 28S ribosomal protein S25, mitochondrial that is encoded in the genome of human.


RT10_HUMAN Small ribosomal subunit protein uS10m (sprot)

A 28S ribosomal protein S10, mitochondrial that is encoded in the genome of human.


RT35_HUMAN Small ribosomal subunit protein mS35 (sprot)

A 28S ribosomal protein S35, mitochondrial that is encoded in the genome of human.


RT05_HUMAN Small ribosomal subunit protein uS5m (sprot)

A 28S ribosomal protein S5, mitochondrial that is encoded in the genome of human.


KGD4_HUMAN Alpha-ketoglutarate dehydrogenase component 4 (sprot)

An alpha-ketoglutarate dehydrogenase component 4 that is encoded in the genome of human.


RT11_HUMAN Small ribosomal subunit protein uS11m (sprot)

A 28S ribosomal protein S11, mitochondrial that is encoded in the genome of human.


RT15_HUMAN Small ribosomal subunit protein uS15m (sprot)

A 28S ribosomal protein S15, mitochondrial that is encoded in the genome of human.


RT21_HUMAN Small ribosomal subunit protein bS21m (sprot)

A 28S ribosomal protein S21, mitochondrial that is encoded in the genome of human.


RT34_HUMAN Small ribosomal subunit protein mS34 (sprot)

A 28S ribosomal protein S34, mitochondrial that is encoded in the genome of human.


RT06_HUMAN Small ribosomal subunit protein bS6m (sprot)

A 28S ribosomal protein S6, mitochondrial that is encoded in the genome of human.


RT09_HUMAN Small ribosomal subunit protein uS9m (sprot)

A 28S ribosomal protein S9, mitochondrial that is encoded in the genome of human.


HMGN5_HUMAN High mobility group nucleosome-binding domain-containing protein 5 (sprot)

A nucleosome-binding protein 1 that is encoded in the genome of human.


SARNP_HUMAN SAP domain-containing ribonucleoprotein (sprot)

A nuclear protein Hcc-1 that is encoded in the genome of human.


RET5_HUMAN Retinol-binding protein 5 (sprot)

A retinol-binding protein 5 that is encoded in the genome of human.


ATL3_HUMAN ADAMTS-like protein 3 (sprot)

An ADAMTS-like protein 3 that is encoded in the genome of human.


HTRA4_HUMAN Serine protease HTRA4 (sprot)

A serine protease HTRA4 that is encoded in the genome of human.


HTRA3_HUMAN Serine protease HTRA3 (sprot)

A serine protease HTRA3 that is encoded in the genome of human.


LACTB_HUMAN Serine beta-lactamase-like protein LACTB, mitochondrial (sprot)

A serine beta-lactamase-like protein LACTB, mitochondrial that is encoded in the genome of human.


LSM11_HUMAN U7 snRNA-associated Sm-like protein LSm11 (sprot)

A U7 snRNA-associated Sm-like protein LSm11 that is encoded in the genome of human.


mRNA 3'-end processing by stem-loop binding and cleavage

Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine.


COG7_HUMAN Conserved oligomeric Golgi complex subunit 7 (sprot)

A conserved oligomeric Golgi complex subunit 7 that is encoded in the genome of human.


retrograde transport, vesicle recycling within Golgi

The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi.


RL24_HUMAN Large ribosomal subunit protein eL24 (sprot)

A 60S ribosomal protein L24 that is encoded in the genome of human.


OX26_HUMAN Orexigenic neuropeptide QRFP (sprot)

An orexigenic neuropeptide QRFP that is encoded in the genome of human.


orexigenic neuropeptide QRFP receptor binding

Binding to an orexigenic neuropeptide QRFP receptor.


TXN4A_HUMAN Thioredoxin-like protein 4A (sprot)

A thioredoxin-like protein 4A that is encoded in the genome of human.


RL36A_HUMAN Large ribosomal subunit protein eL42 (sprot)

A 60S ribosomal protein L36a that is encoded in the genome of human.


CBX1_HUMAN Chromobox protein homolog 1 (sprot)

A chromobox protein homolog 1 that is encoded in the genome of human.


SMAD3_HUMAN Mothers against decapentaplegic homolog 3 (sprot)

A smad3 that is encoded in the genome of human.


nuclear mineralocorticoid receptor binding

Binding to a nuclear mineralocorticoid receptor.


positive regulation of transforming growth factor beta3 production

Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3.


paraxial mesoderm morphogenesis

The process in which the anatomical structures of the paraxial mesoderm are generated and organized.


negative regulation of lung blood pressure

The process that decreases the force with which blood travels through the lungs.


heteromeric SMAD protein complex

A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.


HPCA_HUMAN Neuron-specific calcium-binding protein hippocalcin (sprot)

A neuron-specific calcium-binding protein hippocalcin that is encoded in the genome of human.


response to ketamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus.


response to Aroclor 1254

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus.


ARF1_HUMAN ADP-ribosylation factor 1 (sprot)

An ADP-ribosylation factor 1 that is encoded in the genome of human.


mitotic cleavage furrow ingression

Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed.


ARF5_HUMAN ADP-ribosylation factor 5 (sprot)

An ADP-ribosylation factor 5 that is encoded in the genome of human.


ERH_HUMAN Enhancer of rudimentary homolog (sprot)

An enhancer of rudimentary that is encoded in the genome of human.


RHOG_HUMAN Rho-related GTP-binding protein RhoG (sprot)

A Rho-related GTP-binding protein RhoG that is encoded in the genome of human.


RL19_HUMAN Large ribosomal subunit protein eL19 (sprot)

A 60S ribosomal protein L19 that is encoded in the genome of human.


SERF2_HUMAN Small EDRK-rich factor 2 (sprot)

A small EDRK-rich factor 2 that is encoded in the genome of human.


SRSF3_HUMAN Serine/arginine-rich splicing factor 3 (sprot)

A serine/arginine-rich splicing factor 3 that is encoded in the genome of human.


MXRA7_HUMAN Matrix-remodeling-associated protein 7 (sprot)

A matrix-remodeling-associated protein 7 that is encoded in the genome of human.


H33_HUMAN Histone H3.3 (sprot)

A histone H3.3 that is encoded in the genome of human.


pericentric heterochromatin formation

The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA.


negative regulation of chromosome condensation

Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation.


SKOR1_HUMAN SKI family transcriptional corepressor 1 (sprot)

A ladybird homeobox corepressor 1 that is encoded in the genome of human.


FOXK1_HUMAN Forkhead box protein K1 (sprot)

A forkhead box protein K1 that is encoded in the genome of human.


RHG08_HUMAN Rho GTPase-activating protein 8 (sprot)

A Rho GTPase-activating protein 8 that is encoded in the genome of human.


PRR5_HUMAN Proline-rich protein 5 (sprot)

A protor-1 that is encoded in the genome of human.


HTD2_HUMAN Hydroxyacyl-thioester dehydratase type 2, mitochondrial (sprot)

A hydroxyacyl-thioester dehydratase type 2, mitochondrial that is encoded in the genome of human.


ZBED6_HUMAN Zinc finger BED domain-containing protein 6 (sprot)

A zinc finger BED domain-containing protein 6 that is encoded in the genome of human.


PR20E_HUMAN Proline-rich protein 20E (sprot)

A proline-rich protein 20E that is encoded in the genome of human.


PR20C_HUMAN Proline-rich protein 20C (sprot)

A proline-rich protein 20C that is encoded in the genome of human.


PR20D_HUMAN Proline-rich protein 20D (sprot)

A proline-rich protein 20D that is encoded in the genome of human.


CCZ1B_HUMAN Vacuolar fusion protein CCZ1 homolog B (sprot)

A vacuolar fusion protein CCZ1 homolog B that is encoded in the genome of human.


Mon1-Ccz1 complex

A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p.


CCZ1_HUMAN Vacuolar fusion protein CCZ1 homolog (sprot)

A vacuolar fusion protein CCZ1 homolog that is encoded in the genome of human.


TSG6_HUMAN Tumor necrosis factor-inducible gene 6 protein (sprot)

A tumor necrosis factor-inducible gene 6 protein that is encoded in the genome of human.


ENTK_HUMAN Enteropeptidase (sprot)

An enteropeptidase that is encoded in the genome of human.